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Search of human proteins with 18201909
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18201909 vascular cell adhesion molecule 1 isoform b
precursor [Homo sapiens]
(647 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18201909 vascular cell adhesion molecule 1 isoform b precurso... 1276 0.0
gi|4507875 vascular cell adhesion molecule 1 isoform a precursor... 704 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 115 1e-25
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 106 8e-23
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 106 8e-23
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 106 8e-23
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 106 8e-23
gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens] 96 1e-19
gi|139948432 adlican [Homo sapiens] 95 2e-19
gi|110349719 titin isoform N2-A [Homo sapiens] 92 1e-18
gi|109150416 peroxidasin [Homo sapiens] 92 1e-18
gi|126517478 peroxidasin homolog-like [Homo sapiens] 90 6e-18
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] 88 3e-17
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] 88 3e-17
gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens] 88 3e-17
gi|224994173 roundabout 1 isoform d [Homo sapiens] 87 5e-17
gi|224994171 roundabout 1 isoform c [Homo sapiens] 87 5e-17
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 87 5e-17
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 87 5e-17
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 87 6e-17
gi|11225258 myelin associated glycoprotein isoform a precursor [... 86 1e-16
gi|18104957 myelin associated glycoprotein isoform b precursor [... 86 1e-16
gi|19743806 roundabout 1 isoform b [Homo sapiens] 84 3e-16
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 84 3e-16
gi|4506569 roundabout 1 isoform a [Homo sapiens] 84 4e-16
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi... 84 5e-16
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 84 5e-16
gi|189571583 intercellular adhesion molecule 5 precursor [Homo s... 84 5e-16
gi|4827022 contactin 2 precursor [Homo sapiens] 83 7e-16
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 83 7e-16
>gi|18201909 vascular cell adhesion molecule 1 isoform b precursor
[Homo sapiens]
Length = 647
Score = 1276 bits (3303), Expect = 0.0
Identities = 647/647 (100%), Positives = 647/647 (100%)
Query: 1 MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR 60
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR
Sbjct: 1 MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR 60
Query: 61 TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE 120
TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE
Sbjct: 61 TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE 120
Query: 121 IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV 180
IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV
Sbjct: 121 IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV 180
Query: 181 TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG 240
TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG
Sbjct: 181 TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG 240
Query: 241 SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN 300
SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN
Sbjct: 241 SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN 300
Query: 301 RKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEF 360
RKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEF
Sbjct: 301 RKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEF 360
Query: 361 LEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPR 420
LEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPR
Sbjct: 361 LEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPR 420
Query: 421 DTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKME 480
DTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKME
Sbjct: 421 DTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKME 480
Query: 481 DSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETW 540
DSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETW
Sbjct: 481 DSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETW 540
Query: 541 IILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNK 600
IILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNK
Sbjct: 541 IILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNK 600
Query: 601 DYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYSLVEAQKSKV 647
DYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYSLVEAQKSKV
Sbjct: 601 DYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYSLVEAQKSKV 647
>gi|4507875 vascular cell adhesion molecule 1 isoform a precursor
[Homo sapiens]
Length = 739
Score = 704 bits (1817), Expect = 0.0
Identities = 386/549 (70%), Positives = 431/549 (78%), Gaps = 35/549 (6%)
Query: 109 QVEIYSFPKDPEIHL--SGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLE 166
++++Y PK+ I + S L+ G +T+ CS L + S++
Sbjct: 216 ELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEG-----------LPAPEIFWSKKL-- 262
Query: 167 DADRKSLETKSLEVTFTPV---IEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISP 223
D +L+ S T T + +ED G + VC + V + + KE+++ +
Sbjct: 263 --DNGNLQHLSGNATLTLIAMRMEDSG-IYVC---------EGVNLIGKNRKEVELIVQE 310
Query: 224 KNTVISVNPSTKL--QEGGSVTMTCSSEGLPAPEIFWSKKLDN---GNLQHLSGNATLTL 278
K + ++P ++ Q G SV +TCS G +P W ++D+ G ++ N+TLTL
Sbjct: 311 KPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTL 370
Query: 279 IAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSV 338
+ E+ Y+C K K +++ + +FPRDPEIEMSGGLVNGSSVTVSCKVPSV
Sbjct: 371 SPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSV 430
Query: 339 YPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHID 398
YPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHID
Sbjct: 431 YPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHID 490
Query: 399 DMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQL 458
DMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQL
Sbjct: 491 DMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQL 550
Query: 459 PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPS 518
PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPS
Sbjct: 551 PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPS 610
Query: 519 ESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECES 578
ESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECES
Sbjct: 611 ESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECES 670
Query: 579 KNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYS 638
KNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYS
Sbjct: 671 KNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYS 730
Query: 639 LVEAQKSKV 647
LVEAQKSKV
Sbjct: 731 LVEAQKSKV 739
Score = 653 bits (1684), Expect = 0.0
Identities = 381/624 (61%), Positives = 437/624 (70%), Gaps = 57/624 (9%)
Query: 1 MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR 60
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR
Sbjct: 1 MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR 60
Query: 61 TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE 120
TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE
Sbjct: 61 TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE 120
Query: 121 IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV 180
IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV
Sbjct: 121 IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV 180
Query: 181 TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG 240
TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG
Sbjct: 181 TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG 240
Query: 241 SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN 300
SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN
Sbjct: 241 SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN 300
Query: 301 RKEVELIVQAFPRDPEIEMSGGLVN--GSSVTVSCKV-----PSVYPLDRLEIELLKGET 353
RKEVELIVQ P EI + G SV ++C V PS +++ L G+
Sbjct: 301 RKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQID-SPLSGKV 359
Query: 354 ILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTL 413
E S EN E +++ T+ K L + + ++ F
Sbjct: 360 RSEGTNSTLTLSPVSFEN---EHSYLCTVTCGHKKL--EKGIQVELYSF----------- 403
Query: 414 YVNVAPRDTTVLVSPSSILEEGSSVNMTC-LSQGFPAPKILWSRQLPNGE--LQPLS--- 467
PRD + +S L GSSV ++C + +P ++ +L GE L+ +
Sbjct: 404 -----PRDPEIEMSGG--LVNGSSVTVSCKVPSVYPLDRL--EIELLKGETILENIEFLE 454
Query: 468 -------ENATL--TLISTKMEDSGVYL-------CEGINQAGRSRKEVE-LIIQVTPKD 510
EN +L T I T +ED+G L + + + R+ + L + V P+D
Sbjct: 455 DTDMKSLENKSLEMTFIPT-IEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRD 513
Query: 511 IKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKD 570
+ PS ++EG +V ++C P I+ ++ G+ S + T+ +++D
Sbjct: 514 TTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMED 573
Query: 571 AGVYECESKNKVGSQLRSLTLDVQ 594
+GVY CE N+ G + + L +Q
Sbjct: 574 SGVYLCEGINQAGRSRKEVELIIQ 597
Score = 397 bits (1020), Expect = e-110
Identities = 197/347 (56%), Positives = 257/347 (74%), Gaps = 7/347 (2%)
Query: 18 MFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTT 77
+ + F +E +P R AQIGDSV LTCS GCESP FSWRTQIDSPL+GKV +EGT
Sbjct: 306 LIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTN 365
Query: 78 STLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKC 137
STLT++PVSF NEHSYLCT TC +KLEKGIQVE+YSFP+DPEI +SG L G +TV C
Sbjct: 366 STLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSC 425
Query: 138 SVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRA 197
V VYP DRLEI+LLKG+ ++++ EFLED D KSLE KSLE+TF P IED GK LVC+A
Sbjct: 426 KVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQA 485
Query: 198 KLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIF 257
KLHID+M+ P RQ+ + L V ++P++T + V+PS+ L+EG SV MTC S+G PAP+I
Sbjct: 486 KLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKIL 545
Query: 258 WSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEI 317
WS++L NG LQ LS NATLTLI+ +MEDSG+Y+CEG+N G++RKEVELI+Q P+D ++
Sbjct: 546 WSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKL 605
Query: 318 EM--SGGLVNGSSVTVSC---KVPSVYPLDRLEIELLKGETILENIE 359
S + G +V +SC VP + + + + E G+T+L++I+
Sbjct: 606 TAFPSESVKEGDTVIISCTCGNVPETWIILKKKAE--TGDTVLKSID 650
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 115 bits (289), Expect = 1e-25
Identities = 149/595 (25%), Positives = 244/595 (41%), Gaps = 88/595 (14%)
Query: 40 GDSVSLTCSTTGCESPFFSW--RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHS--YLC 95
G V+L C +G P W + ++ S + K + S ++P G E S Y+C
Sbjct: 995 GIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSP---GGEESGEYVC 1051
Query: 96 TATCESRKLEKGIQVEIYSFPK----------DPEIHLSGPLEAGKPITVKCSVADVYPF 145
TAT + ++ +Q+ +Y P+ D + +S + AG+ +T+ C V + P
Sbjct: 1052 TATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEIS--VLAGEEVTLPCEVKSLPP- 1108
Query: 146 DRLEIDLLKGDHLMKS----QEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHI 201
I K L+ FL K ET++ D G L +
Sbjct: 1109 --PIITWAKETQLISPFSPRHTFLPSGSMKITETRT---------SDSGMYLCVATNI-- 1155
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPS-TKLQEGGSVTMTCSSEGLPAPEIFWSK 260
V QAVK L V++ PK I P K+Q G V + C+++G P P I WSK
Sbjct: 1156 -----AGNVTQAVK-LNVHVPPK---IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSK 1206
Query: 261 ----KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPE 316
L +G + + TL++ D+GIY C N+ G + E+ L VQ P +
Sbjct: 1207 GGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVED 1266
Query: 317 IEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEM 376
+E + T +V + R+E T I++L + + L + +
Sbjct: 1267 LEPP------YNTTFQERVAN----QRIEFPCPAKGTPKPTIKWLHNG--RELTGREPGI 1314
Query: 377 TFIPTIEDTGKALVCQAKLHIDDMEF------EPKQRQSTQTLYVNVAP--RDTTVLVSP 428
+ + + G LV + D+ E+ E + L V+V P +D + +
Sbjct: 1315 SIL----EDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNV 1370
Query: 429 SSILEEGSSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGV 484
S +L + N+ C +G P+P I+W + + +Q ++ L L ED+G
Sbjct: 1371 SVLLNQ--LTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGR 1428
Query: 485 YLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGNVPET---W 540
Y C+ IN AG S+K + + V P I T FP+E SV V + C P W
Sbjct: 1429 YSCKAINIAGTSQKYFNIDVLVPPTIIG-TNFPNEVSVVLNRDVALECQVKGTPFPDIHW 1487
Query: 541 IILKKKAETGDTVLKSIDGAYT--IRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
K GD ++ +D ++ A+ D G Y+C N G Q + + L +
Sbjct: 1488 FKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTI 1542
Score = 113 bits (283), Expect = 5e-25
Identities = 141/583 (24%), Positives = 237/583 (40%), Gaps = 68/583 (11%)
Query: 39 IGDSVSLTCSTTGCESPFFSWR---TQIDSPLNG-KVTNEGTTSTLTMNPVSFGNEHSYL 94
+ + V L C G +P +W + + S NG +V + G LT +S + Y
Sbjct: 2025 VNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQIS--DTGRYT 2082
Query: 95 CTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLK 154
C A + + ++ I + +Y P + + + + + C +D P L L
Sbjct: 2083 CVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQ-SDAIPPPTLTW-LKD 2140
Query: 155 GDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAV 214
G L+K +R L+ + +V +D G+ + E +V +
Sbjct: 2141 GHPLLKKPGLSISENRSVLKIEDAQV------QDTGR--------YTCEATNVAGKTEKN 2186
Query: 215 KELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK-----LDN-GNLQ 268
+ +++ P + EG +++ C S G+P P + W KK D+ G ++
Sbjct: 2187 YNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVR 2246
Query: 269 HLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGG------ 322
LSG L + D+ +Y C N+ G +KE L Q + R P I SG
Sbjct: 2247 ILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNL--QVYIR-PTITNSGSHPTEII 2303
Query: 323 LVNGSSVTVSCKVPSVYPLDRLEIELLKGETILE--NIEFLEDTDMKSLENKSLEMTFIP 380
+ G S+++ C+V + P ++ G +++ +E L++ + L+N
Sbjct: 2304 VTRGKSISLECEVQGIPPPTVTWMK--DGHPLIKAKGVEILDEGHILQLKNIH------- 2354
Query: 381 TIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSI-LEEGSSVN 439
+ DTG+ VC A +++ M L V+ P SP +I + E +SV+
Sbjct: 2355 -VSDTGR-YVCVA-VNVAGMT------DKKYDLSVHAPPSIIGNHRSPENISVVEKNSVS 2405
Query: 440 MTCLSQGFPAPKILWSRQ-----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAG 494
+TC + G P P I W + L N ++ LS L L+ T MED+G Y C N AG
Sbjct: 2406 LTCEASGIPLPSITWFKDGWPVSLSNS-VRILSGGRMLRLMQTTMEDAGQYTCVVRNAAG 2464
Query: 495 RSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAE--TGDT 552
RK L + V P + VKE +V ++C P I K + D
Sbjct: 2465 EERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDE 2524
Query: 553 VLKSIDGA--YTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
I G I Q+ G Y C + + G + RS +L+V
Sbjct: 2525 AHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV 2567
Score = 110 bits (275), Expect = 4e-24
Identities = 142/575 (24%), Positives = 234/575 (40%), Gaps = 67/575 (11%)
Query: 39 IGDSVSLTCSTTGCESPFFSWRTQ-IDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTA 97
+ + + L C TG SPF +W+ + I+ +G+ + L ++ + +Y+C A
Sbjct: 4001 LNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVA 4060
Query: 98 TCESR----KLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLL 153
+ K++ +QV P E ++ KPIT+ C + P D I
Sbjct: 4061 QNPAGTALGKIKLNVQVPPVISPHLKEYVIA----VDKPITLSCEADGLPPPD---ITWH 4113
Query: 154 KGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQA 213
K + +E ++ L + SL++ F D G A + S
Sbjct: 4114 KD-----GRAIVESIRQRVLSSGSLQIAFVQP-GDAGHYTCMAANVAGSSSTST------ 4161
Query: 214 VKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGN 273
+L V++ P+ + S + E + C ++G+P P I W K DN L +L G
Sbjct: 4162 --KLTVHVPPR--IRSTEGHYTVNENSQAILPCVADGIPTPAINWKK--DNVLLANLLGK 4215
Query: 274 AT------LTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGS 327
T L L + +EDSG Y C N G++ V L V P E+ L G
Sbjct: 4216 YTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGE 4275
Query: 328 SVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGK 387
+ +SCK + PL +L T NI S+ S + + ED+G
Sbjct: 4276 QLRLSCKATGI-PLPKLT------WTFNNNI---IPAHFDSVNGHSELVIERVSKEDSG- 4324
Query: 388 ALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEE-GSSVNMTCLSQG 446
VC A+ + + ++ +YV P PS+ +E G + + C +G
Sbjct: 4325 TYVCTAENSVGFV-------KAIGFVYVKEPP--VFKGDYPSNWIEPLGGNAILNCEVKG 4375
Query: 447 FPAPKILWSRQLPNGELQPLSE---NATLTLISTKMEDSGVYLCEGINQAGRSRKEVELI 503
P P I W+R+ + E+ N +L + T ED+G Y C N+AG + + L
Sbjct: 4376 DPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4435
Query: 504 IQVTPKDIKLTAFPSESV-KEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDG 559
+Q P +T P E+V G +I++C P+ TW D V +
Sbjct: 4436 LQSPP---IITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNN 4492
Query: 560 AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
+ I AQ +D +EC ++N +GS L + + VQ
Sbjct: 4493 SLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQ 4527
Score = 108 bits (269), Expect = 2e-23
Identities = 139/595 (23%), Positives = 234/595 (39%), Gaps = 76/595 (12%)
Query: 39 IGDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
+ SL C +W T ++S N ++ G T L + N Y C
Sbjct: 2589 LNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRT--LQILNAQEDNAGRYSC 2646
Query: 96 TATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCS-----VADVYPFDRLEI 150
AT E+ ++ K +V++Y P + L GP + K + +K + + Y +
Sbjct: 2647 VATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 151 DLLKGDHLMKSQEFLE-DADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPT 209
K +KS + + A+ +L+ K +++ T + + +L D VP
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPP 2766
Query: 210 VRQAVKELQVYISPKNT-----VISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK--- 261
Q + E+ + VI NP +++ C + P P + W K
Sbjct: 2767 SFQKLWEIGNMLDTGRNGEAKDVIINNP---------ISLYCETNAAPPPTLTWYKDGHP 2817
Query: 262 -LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVEL------IVQAFPRD 314
+ + L G L + ++ED+G Y C VN G++ + ++ I++ D
Sbjct: 2818 LTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSD 2877
Query: 315 PEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSL 374
E++ LVN S++ S P + + + G+ +LE D K L N +
Sbjct: 2878 LPEEVTV-LVNKSALIECLSSGSPAPRNSWQKD---GQPLLE------DDHHKFLSNGRI 2927
Query: 375 EMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSS---I 431
I D G+ VC A+ + Y N+ ++ P S
Sbjct: 2928 LQILNTQITDIGR-YVCVAE-----------NTAGSAKKYFNLNVHVPPSVIGPKSENLT 2975
Query: 432 LEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENA-------TLTLISTKMEDSGV 484
+ + +++TC GFP P + W L N + L+ N TL +I K+ D G
Sbjct: 2976 VVVNNFISLTCEVSGFPPPDLSW---LKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGE 3032
Query: 485 YLCEGINQAGRSRKEVELIIQVTP--KDIKLTAFPSESVKEGDTVIISCTCGNVPE---T 539
Y C INQAG S+K+ L + V P KD + +V+EG +V + C VP T
Sbjct: 3033 YTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVIT 3092
Query: 540 WIILKKKAETGDTVLKSIDGAYT-IRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
W + V DG I+KA++ D G Y C + N G ++ L+V
Sbjct: 3093 WYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNV 3147
Score = 104 bits (260), Expect = 2e-22
Identities = 127/469 (27%), Positives = 195/469 (41%), Gaps = 80/469 (17%)
Query: 162 QEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYI 221
Q LED K L + I DIG+ VC A+ + V +
Sbjct: 2911 QPLLEDDHHKFLSNGRILQILNTQITDIGRY-VCVAENTAGSAKKYFNLNVHVPPSVIGP 2969
Query: 222 SPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLD----NGNLQHLSGNATLT 277
+N + VN +++TC G P P++ W K N N + G TL
Sbjct: 2970 KSENLTVVVN--------NFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQ 3021
Query: 278 LIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFP--RDPEIEMSGGLVN---GSSVTVS 332
+I ++ D G Y C +N G+++K+ L V P +D + E S +VN G+SV++
Sbjct: 3022 IIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSE-SLSVVNVREGTSVSLE 3080
Query: 333 CKVPSVYPLDRLEIELLKGETILEN--IEFLEDTDMKSLENKSLEMTFIPTIEDTGKALV 390
C+ +V P + G I E+ +E L D M ++ + DTG+ V
Sbjct: 3081 CESNAVPP--PVITWYKNGRMITESTHVEILADGQMLHIKKAE--------VSDTGQ-YV 3129
Query: 391 CQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDT-----TVLVSPSS-------ILEEGSS- 437
C+A +NVA RD V V PS I+E S+
Sbjct: 3130 CRA---------------------INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNP 3168
Query: 438 VNMTCLSQGFPAPKILW---SRQLPNG---ELQPLSENATLTLISTKMEDSGVYLCEGIN 491
V +TC + G P P I W +++ N E++ LS + L + ++ DSG Y C N
Sbjct: 3169 VTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASN 3228
Query: 492 QAGRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGNVPE---TWIILKKKA 547
G+++K L IQV P + PS+ SV G+ V + C +P W+ K
Sbjct: 3229 MEGKAQKYYFLSIQV-PPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPI 3287
Query: 548 ETGDT--VLKSIDGA-YTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
+G+T + S +G+ I A D G Y C + N G + R L+V
Sbjct: 3288 ASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNV 3336
Score = 103 bits (256), Expect = 6e-22
Identities = 135/628 (21%), Positives = 251/628 (39%), Gaps = 91/628 (14%)
Query: 5 MVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQ-- 62
MV G S+ + + K+ P+++ G VS+ CS TG P +W
Sbjct: 592 MVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTG-GSEVSIMCSATGYPKPKIAWTVNDM 650
Query: 63 -IDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEI 121
I ++T++GT P G Y C A+ + ++ + PK +
Sbjct: 651 FIVGSHRYRMTSDGTLFIKNAAPKDAG---IYGCLASNSAGTDKQNSTLRYIEAPKLMVV 707
Query: 122 HLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVT 181
+ G ++C + + P ++ KGD ++ FL
Sbjct: 708 QSELLVALGDITVMECKTSGIPP---PQVKWFKGDLELRPSTFL---------------- 748
Query: 182 FTPVIEDIGKVLVCRAKLHIDEMD----SVPTVRQAVKELQVYISPKNTVISVNPSTKLQ 237
+I+ + +L + +D D ++ +A ++ + + I ++
Sbjct: 749 ---IIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSME 805
Query: 238 EGGSVTMTCSSEGLPAPEIFWSKKLDN----------GNLQHLSGNATLTLIAMRMEDSG 287
G +VT+ C +G P P I W ++LDN ++ L A L ++ + D G
Sbjct: 806 IGSNVTLPCYVQGYPEPTIKW-RRLDNMPIFSRPFSVSSISQLRTGA-LFILNLWASDKG 863
Query: 288 IYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVN---GSSVTVSCKVPSVYPLDRL 344
Y+CE N GK + E + V P I +S + N G +T+ C + + P+
Sbjct: 864 TYICEAENQFGKIQSETTVTVTGLVA-PLIGISPSVANVIEGQQLTLPCTLLAGNPIP-- 920
Query: 345 EIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEP 404
E +K +L ++ SL + +++ +D G+ + +
Sbjct: 921 ERRWIKNSAMLLQNPYITVRSDGSLHIERVQL------QDGGEYTCVASNV--------A 966
Query: 405 KQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQ 464
T ++ V+V P S+I EG V + C + G P P ++WS++ GEL
Sbjct: 967 GTNNKTTSVVVHVLPTIQHGQQILSTI--EGIPVTLPCKASGNPKPSVIWSKK---GELI 1021
Query: 465 PLSE-------NATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFP 517
S + +L ++S E+SG Y+C N AG ++++V+L + V P+
Sbjct: 1022 STSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGL 1081
Query: 518 SE------SVKEGDTVIISCTCGNVPETWIILKKKAE------TGDTVLKSIDGAYTIRK 565
S+ SV G+ V + C ++P I K+ + T L S G+ I +
Sbjct: 1082 SQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPS--GSMKITE 1139
Query: 566 AQLKDAGVYECESKNKVGSQLRSLTLDV 593
+ D+G+Y C + N G+ +++ L+V
Sbjct: 1140 TRTSDSGMYLCVATNIAGNVTQAVKLNV 1167
Score = 102 bits (254), Expect = 1e-21
Identities = 146/606 (24%), Positives = 241/606 (39%), Gaps = 75/606 (12%)
Query: 32 ESRYLAQIGDSVSLTCSTTGCESPFFSW-RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNE 90
+S L +GD + C T+G P W + ++ + + + L + +
Sbjct: 708 QSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDA 767
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEI 150
Y C A E+ + I +++ S P + +E G +T+ C V YP ++
Sbjct: 768 GDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQG-YPEPTIKW 826
Query: 151 DLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTV 210
L D++ + L T +L + D G +C A+ ++ S TV
Sbjct: 827 RRL--DNMPIFSRPFSVSSISQLRTGALFI-LNLWASDKG-TYICEAENQFGKIQSETTV 882
Query: 211 RQAVKELQVYISPKNTVISVNPST-KLQEGGSVTMTCSS-EGLPAPEIFWSKK----LDN 264
+ ++P +I ++PS + EG +T+ C+ G P PE W K L N
Sbjct: 883 T-----VTGLVAP---LIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQN 934
Query: 265 GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLV 324
+ + + +L + ++++D G Y C N+ G N K ++V P + +
Sbjct: 935 PYIT-VRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTI 993
Query: 325 NGSSVTVSCKV-----PSVYPLDRLEIELLKGETI-LENIEFLEDTDMKSLENKSLEMTF 378
G VT+ CK PSV I KGE I + +F D SL +
Sbjct: 994 EGIPVTLPCKASGNPKPSV-------IWSKKGELISTSSAKFSAGAD------GSLYVVS 1040
Query: 379 IPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPR----------DTTVLVSP 428
P E++G+ VC A + + ++ Q T V V PR D V +S
Sbjct: 1041 -PGGEESGE-YVCTAT---NTAGYAKRKVQLT----VYVRPRVFGDQRGLSQDKPVEISV 1091
Query: 429 SSILEEGSSVNMTCLSQGFPAPKILWSRQL----PNGELQPLSENATLTLISTKMEDSGV 484
+ G V + C + P P I W+++ P + ++ + T+ DSG+
Sbjct: 1092 LA----GEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGM 1147
Query: 485 YLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGNVPETWIIL 543
YLC N AG + V+L + V P K+ P V+ G V I C P I
Sbjct: 1148 YLCVATNIAGNVTQAVKLNVHVPP---KIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITW 1204
Query: 544 KKKAET----GDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENN 599
K T G+ + + DG +I +A DAG+Y C + N G+ +TL VQ
Sbjct: 1205 SKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTV 1264
Query: 600 KDYFSP 605
+D P
Sbjct: 1265 EDLEPP 1270
Score = 97.4 bits (241), Expect = 4e-20
Identities = 143/583 (24%), Positives = 221/583 (37%), Gaps = 77/583 (13%)
Query: 40 GDSVSLTCSTTGCESPFFSW-RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
G S S+ C T G +P +W R L+ +T L + + Y C A+
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIAS 3509
Query: 99 CESRKLEKGIQVEIYSFP--KDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGD 156
E+ ++ K +++ P E H + P+ + C +A P ++
Sbjct: 3510 NEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTC-IASGIPAPKMT------- 3561
Query: 157 HLMKSQEFLEDADR-KSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVK 215
MK L D+ ++L + T +ED G+ C A + D VR
Sbjct: 3562 -WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRY-TCLASSPAGDDDKEYLVR---- 3615
Query: 216 ELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGN-------LQ 268
V++ P + VT+ C S+ +P P I W L NG ++
Sbjct: 3616 ---VHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITW---LRNGERLQATPRVR 3669
Query: 269 HLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSS 328
LSG L + + D+ Y C N+ GK +E L V P S ++ S
Sbjct: 3670 ILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKS 3729
Query: 329 VTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA 388
+ C V P R I K +L LEN L + + DTG+
Sbjct: 3730 TVLECIAEGV-PTPR--ITWRKDGAVLAG----NHARYSILENGFLHIQSAH-VTDTGRY 3781
Query: 389 LVCQAKLHIDDMEFEPKQRQSTQTLYV--NVAPRDT--TVLVSPSSILEEGSSVNMTCLS 444
L D +R+ ++V ++AP T TV+V+ + L C +
Sbjct: 3782 LCMATNAAGTD------RRRIDLQVHVPPSIAPGPTNMTVIVNVQTTL--------ACEA 3827
Query: 445 QGFPAPKILWSRQLPNGELQPLSEN---------ATLTLISTKMEDSGVYLCEGINQAGR 495
G P P I W + NG L + +N +L +IS ++D+ Y C N AG
Sbjct: 3828 TGIPKPSINWRK---NGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGD 3884
Query: 496 SRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGNVPETWIILKKKA----ETG 550
++ V+L +QV P + P++ V + +I+CT VP I K G
Sbjct: 3885 DKRTVDLTVQVPP---SIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRG 3941
Query: 551 DTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
D GA I QL AG Y C ++N GS R +TL V
Sbjct: 3942 DGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHV 3984
Score = 95.5 bits (236), Expect = 1e-19
Identities = 135/584 (23%), Positives = 233/584 (39%), Gaps = 76/584 (13%)
Query: 39 IGDSVSLTCSTTGCESPFFSW-RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTA 97
I S++L C G SP +W + + N + E L + + Y+C A
Sbjct: 1655 IAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVA 1714
Query: 98 TCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDH 157
T + + E +V++ P +E G + S V + LE+D
Sbjct: 1715 TSVAGEKEIKYEVDVLVPPA---------IEGGD----ETSYFIVMVNNLLELDCHVTGS 1761
Query: 158 LMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKEL 217
+ +L+D E ++ I + V L+ + T KE
Sbjct: 1762 PPPTIMWLKDGQLID-ERDGFKILLNGRKLVIAQAQVSNTGLY--RCMAANTAGDHKKEF 1818
Query: 218 QVYISPKNTVISVNPSTKLQ-EGGSVTMTCSSEGLPAPEIFWSK-----KLDNGNLQHLS 271
+V + T+ S S ++ + V + C + G+P P I W K GNL+ S
Sbjct: 1819 EVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQS 1878
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTV 331
L + +ED+G Y C N G+ ++ ++L V P +E +G ++N +V V
Sbjct: 1879 SGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVH---EPPSLEDAGKMLN-ETVLV 1934
Query: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFI--PTIEDTGKAL 389
S + +++E + I + +D + S S MTF+ I D A
Sbjct: 1935 S---------NPVQLECKAAGNPVPVITWYKDNRLLS---GSTSMTFLNRGQIIDIESAQ 1982
Query: 390 VCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSS---ILEEGSSVNMTCLSQG 446
+ A ++ + +L V+VAP +S S+ + + V + C ++G
Sbjct: 1983 ISDAGIYKCVAINSAGATELFYSLQVHVAPS-----ISGSNNMVAVVVNNPVRLECEARG 2037
Query: 447 FPAPKILWSR------QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEV 500
PAP + W + NG LQ LS L L S ++ D+G Y C +N AG ++++
Sbjct: 2038 IPAPSLTWLKDGSPVSSFSNG-LQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDI 2096
Query: 501 ELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWI-----ILKK---KAET 549
+L + V P + + SV V + C +P TW+ +LKK
Sbjct: 2097 DLRVYVPPN--IMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISE 2154
Query: 550 GDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
+VLK I AQ++D G Y CE+ N G ++ +++
Sbjct: 2155 NRSVLK-------IEDAQVQDTGRYTCEATNVAGKTEKNYNVNI 2191
Score = 95.1 bits (235), Expect = 2e-19
Identities = 125/580 (21%), Positives = 236/580 (40%), Gaps = 69/580 (11%)
Query: 39 IGDSVSLTCSTTGCESPFFSW-RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTA 97
+ + + LTC +G +P +W + P +V G L ++ + Y C A
Sbjct: 3542 VNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLA 3601
Query: 98 TCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-------GKPITVKCSVADVYPFDRLEI 150
+ + +K V ++ P +++G E + +T++C V P +
Sbjct: 3602 SSPAGDDDKEYLVRVHVPP-----NIAGTDEPRDITVLRNRQVTLECKSDAVPP--PVIT 3654
Query: 151 DLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTV 210
L G+ L + + + L+ + ++ T + + + +VP
Sbjct: 3655 WLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPP- 3713
Query: 211 RQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGN 266
+ P++ VI +N ST L+ C +EG+P P I W K N
Sbjct: 3714 -------NIKGGPQSLVILLNKSTVLE--------CIAEGVPTPRITWRKDGAVLAGNHA 3758
Query: 267 LQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNG 326
+ N L + + + D+G Y+C N G +R+ ++L V P + ++
Sbjct: 3759 RYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVN 3818
Query: 327 SSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTG 386
T++C+ + + I K +L N++ +++ + L + SL + P+++DT
Sbjct: 3819 VQTTLACEATGI---PKPSINWRKNGHLL-NVDQNQNS-YRLLSSGSL-VIISPSVDDTA 3872
Query: 387 KALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSIL-EEGSSVNMTCLSQ 445
DD + T L V V P ++ P+ L + + +TC +
Sbjct: 3873 TYECTVTNGAGDD--------KRTVDLTVQVPP---SIADEPTDFLVTKHAPAVITCTAS 3921
Query: 446 GFPAPKILWS----RQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVE 501
G P P I W+ R LP G+ + + + +++T++ +G Y C N AG + + V
Sbjct: 3922 GVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVT 3981
Query: 502 LIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGNVPETWIILKKKAETGDT------VL 554
L + P + PSE V + +++ C P +I +K+ +T VL
Sbjct: 3982 LHVHEPP---VIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVL 4038
Query: 555 KSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
S G I +A +DAG Y C ++N G+ L + L+VQ
Sbjct: 4039 PS--GGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQ 4076
Score = 92.8 bits (229), Expect = 9e-19
Identities = 137/603 (22%), Positives = 244/603 (40%), Gaps = 98/603 (16%)
Query: 40 GDSVSLTCSTTGCESPFFSWRTQIDSPLN---GKVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G+ +SL C ++G P W+ + L G+V L ++ + Y C
Sbjct: 2211 GNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCV 2270
Query: 97 ATCESRKLEKGIQVEIYSFPKDPEIHLSG--PLEA----GKPITVKCSVADVYPFDRLEI 150
A+ + +K +++Y P I SG P E GK I+++C V + P +
Sbjct: 2271 ASNVAGTAKKEYNLQVYI---RPTITNSGSHPTEIIVTRGKSISLECEVQGIPP---PTV 2324
Query: 151 DLLKGDHLMKSQEFLEDADRKS-LETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPT 209
+K H + + +E D L+ K++ V+ D G+ VC A +V
Sbjct: 2325 TWMKDGHPLIKAKGVEILDEGHILQLKNIHVS------DTGRY-VCVAV-------NVAG 2370
Query: 210 VRQAVKELQVYISPKNTVISVNPST-KLQEGGSVTMTCSSEGLPAPEIFWSK-----KLD 263
+ +L V+ P +P + E SV++TC + G+P P I W K L
Sbjct: 2371 MTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLS 2430
Query: 264 NGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR---DPEIEMS 320
N +++ LSG L L+ MED+G Y C N G+ RK L V P + +E
Sbjct: 2431 N-SVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLE-D 2488
Query: 321 GGLVNGSSVTVSCKVPS------VYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSL 374
+ SVT++C+V + D ++ + I+ FL+ T+++
Sbjct: 2489 VKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQ------- 2541
Query: 375 EMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVA---------PRDTTVL 425
+ TG+ C A K R + ++V+ P D TV+
Sbjct: 2542 -------VPHTGR-YTCLASSPAGH-----KSRSFSLNVFVSPTIAGVGSDGNPEDVTVI 2588
Query: 426 VSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMED 481
++ S ++ C + +P I W + N ++ L TL +++ + ++
Sbjct: 2589 LN--------SPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDN 2640
Query: 482 SGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAF-----PSE-SVKEGDTVIISCTCGN 535
+G Y C N+AG K E+ + + P K + P E +K +T+ + C
Sbjct: 2641 AGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYA 2700
Query: 536 VPE---TWIILKKKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGSQLRSLTL 591
+P +W + ++ D V + +G I++AQ+ D G Y C + N G +
Sbjct: 2701 IPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDV 2760
Query: 592 DVQ 594
++Q
Sbjct: 2761 NIQ 2763
Score = 90.9 bits (224), Expect = 3e-18
Identities = 120/587 (20%), Positives = 218/587 (37%), Gaps = 78/587 (13%)
Query: 40 GDSVSLTCSTTGCESPFFSW--RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTA 97
G+ V+L C P +W TQ+ SP + + T + S + + + YLC A
Sbjct: 1094 GEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGS-MKITETRTSDSGMYLCVA 1152
Query: 98 TCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEID------ 151
T + + + +++ ++ PK ++ G+ + + C+ A P +
Sbjct: 1153 TNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCN-AQGTPLPVITWSKGGSTM 1211
Query: 152 LLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVR 211
L+ G+H + + + D+ T S +T V +I LH+ E +V +
Sbjct: 1212 LVDGEHHVSNPDGTLSIDQA---TPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLE 1268
Query: 212 QAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGN----- 266
P NT + + + C ++G P P I W L NG
Sbjct: 1269 P----------PYNTTFQERVANQ-----RIEFPCPAKGTPKPTIKW---LHNGRELTGR 1310
Query: 267 ---LQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFP--RDPEIEMSG 321
+ L L + ++ D+G Y+C VN G ++ L V P +D E +
Sbjct: 1311 EPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNV 1370
Query: 322 GLVNGSSVTVSCKVPSVYPLDRLEIELLKGETIL---ENIEFLEDTDMKSLENKSLEMTF 378
++ + C E+E I+ +N++ E + ++++ N + F
Sbjct: 1371 SVLLNQLTNLFC-----------EVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLF 1419
Query: 379 IPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSV 438
T ED G+ + ++ T+ P + +V+++ LE
Sbjct: 1420 RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALE----- 1474
Query: 439 NMTCLSQGFPAPKILWSRQ-----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQA 493
C +G P P I W + L + ++ L L L + + D G Y C N A
Sbjct: 1475 ---CQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAA 1531
Query: 494 GRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTV 553
G+ K+++L I + P SV + + C +P I K G +
Sbjct: 1532 GKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYK---DGQPI 1588
Query: 554 LKSIDGAYT-------IRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
+ S Y I +AQ+ D+ Y C N G+ +S +DV
Sbjct: 1589 MSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDV 1635
Score = 90.1 bits (222), Expect = 6e-18
Identities = 145/622 (23%), Positives = 248/622 (39%), Gaps = 73/622 (11%)
Query: 31 PESRYLAQ-IGDSVSLTCSTTGCESPFFSW-----RTQIDSPLNGKVTNEGTTSTLTMNP 84
PE + + I + V+LTC TG P +W R + L ++ + G S L +
Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGG--SKLQIAR 3213
Query: 85 VSFGNEHSYLCTATCESRKLEK--GIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADV 142
+ +Y C A+ K +K + +++ EI + G+ + + C+ +
Sbjct: 3214 SQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGI 3273
Query: 143 YPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHID 202
I LK + S E + R S +L + + + D GK C A
Sbjct: 3274 ---PTPLIQWLKDGKPIASGE--TERIRVSANGSTLNI-YGALTSDTGK-YTCVATNPAG 3326
Query: 203 EMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQE--GGSVTMTCSSEGLPAPEIFWSK 260
E D + L VY++P + + + KL S+ + C + G P P+I W
Sbjct: 3327 EED-------RIFNLNVYVTP-TIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW-- 3376
Query: 261 KLDNG-------NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR 313
L NG +++ L+ + ++ ++ D +Y C N G + K L V A
Sbjct: 3377 -LKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFA--- 3432
Query: 314 DPEIEMSGG-----LVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKS 368
P ++ S G ++ GSS +++C + P + L G+ + + T
Sbjct: 3433 PPNMDNSMGTEEITVLKGSSTSMAC-ITDGTPAPSM-AWLRDGQPLGLDAHLTVSTHGMV 3490
Query: 369 LENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSP 428
L+ E ED+GK C A ++ + + + ++N + + V
Sbjct: 3491 LQLLKAE------TEDSGK-YTCIASNEAGEVS-KHFILKVLEPPHINGSEEHEEISVIV 3542
Query: 429 SSILEEGSSVNMTCLSQGFPAPKILW---SRQLP-NGELQPLSENATLTLISTKMEDSGV 484
++ LE +TC++ G PAPK+ W R LP ++Q L L + + ++ED+G
Sbjct: 3543 NNPLE------LTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGR 3596
Query: 485 YLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGNVPE---TW 540
Y C + AG KE + + V P +I T P + +V V + C VP TW
Sbjct: 3597 YTCLASSPAGDDDKEYLVRVHV-PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITW 3655
Query: 541 IILKKKAETGDTVLKSIDGAY-TIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENN 599
+ ++ + V G Y I A L D Y C + N G R L V N
Sbjct: 3656 LRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNI 3715
Query: 600 KDYFSPELLVLYFASSLIIPAI 621
K P+ LV+ S ++ I
Sbjct: 3716 KG--GPQSLVILLNKSTVLECI 3735
Score = 89.0 bits (219), Expect = 1e-17
Identities = 139/606 (22%), Positives = 220/606 (36%), Gaps = 106/606 (17%)
Query: 33 SRYLAQIGDSVSLTCSTTGCESPFFSWRTQ---IDSPLNGKVTNEGTTSTLTMNPVSFGN 89
S ++ + + + L C TG P W ID K+ G + VS N
Sbjct: 1742 SYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVS--N 1799
Query: 90 EHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLE----AGKPITVKCS------- 138
Y C A + +K +V ++ P I SG E KP+ ++C
Sbjct: 1800 TGLYRCMAANTAGDHKKEFEVTVH---VPPTIKSSGLSERVVVKYKPVALQCIANGIPNP 1856
Query: 139 ----VADVYPFDRLEIDL---LKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGK 191
+ D P + + +L G L ++ LEDA R +T V +
Sbjct: 1857 SITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGR-----------YTCVATNAAG 1905
Query: 192 VLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGL 251
+LH+ E P++ A K L TV+ NP V + C + G
Sbjct: 1906 ETQQHIQLHVHE---PPSLEDAGKML------NETVLVSNP---------VQLECKAAGN 1947
Query: 252 PAPEIFWSKKLDNGNLQHLSGNATLTLI---------AMRMEDSGIYVCEGVNLIGKNRK 302
P P I W K DN + LSG+ ++T + + ++ D+GIY C +N G
Sbjct: 1948 PVPVITWYK--DN---RLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATEL 2002
Query: 303 EVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLE 362
L V P +V + V + C+ + + LK + + +
Sbjct: 2003 FYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGI---PAPSLTWLKDGSPVSSF---- 2055
Query: 363 DTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYV--NVAPR 420
++ L + I DTG+ C A + KQR +YV N+
Sbjct: 2056 SNGLQVLSGGRILALTSAQISDTGR-YTCVAVNAAGE-----KQRDIDLRVYVPPNIMGE 2109
Query: 421 DTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENATLTLIS 476
+ V V S +V + C S P P + W + L L + L +
Sbjct: 2110 EQNVSVLIS------QAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIED 2163
Query: 477 TKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNV 536
+++D+G Y CE N AG++ K + I V P +V EG+ + + C +
Sbjct: 2164 AQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGI 2223
Query: 537 PETWIILKKKAETGDTVLKSIDGAYTIRK---------AQLKDAGVYECESKNKVGSQLR 587
P +I KKK G VL G I A+ DA +Y C + N G+ +
Sbjct: 2224 PPPNLIWKKK---GSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKK 2280
Query: 588 SLTLDV 593
L V
Sbjct: 2281 EYNLQV 2286
Score = 89.0 bits (219), Expect = 1e-17
Identities = 101/428 (23%), Positives = 171/428 (39%), Gaps = 42/428 (9%)
Query: 217 LQVYISPK-----NTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNL 267
L VY+ P + +SV ++EG SV++ C S +P P I W K ++ ++
Sbjct: 3050 LTVYVPPSIKDHDSESLSV---VNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHV 3106
Query: 268 QHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFP--RDPEIEMSGGLVN 325
+ L+ L + + D+G YVC +N+ G++ K L V P PE E+ ++
Sbjct: 3107 EILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETIS 3166
Query: 326 GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDT 385
+ VT++C + P I LK +EN + LE ++ L S D+
Sbjct: 3167 -NPVTLTCDATGIPPPT---IAWLKNHKRIENSDSLE---VRILSGGSKLQIARSQHSDS 3219
Query: 386 GKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQ 445
G + + ++ Q ++ P D +VL+ G +V + C +
Sbjct: 3220 GNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLL--------GENVELVCNAN 3271
Query: 446 GFPAPKILW---SRQLPNGELQPLSENA---TLTLISTKMEDSGVYLCEGINQAGRSRKE 499
G P P I W + + +GE + + +A TL + D+G Y C N AG +
Sbjct: 3272 GIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRI 3331
Query: 500 VELIIQVTPKDIKLTAFPSESVKE--GDTVIISCTCGNVPETWIILKKKA----ETGDTV 553
L + VTP I+ +E + ++ I C P I K +
Sbjct: 3332 FNLNVYVTP-TIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIR 3390
Query: 554 LKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFA 613
L + I +AQ+ D VY C + N+ G + L V N + E + +
Sbjct: 3391 LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKG 3450
Query: 614 SSLIIPAI 621
SS + I
Sbjct: 3451 SSTSMACI 3458
Score = 87.8 bits (216), Expect = 3e-17
Identities = 126/565 (22%), Positives = 215/565 (38%), Gaps = 76/565 (13%)
Query: 44 SLTCSTTGCESPFFSWRTQ-----IDSPLNG-KVTNEGTTSTLTMNPVSFGNEHSYLCTA 97
+L C TG P +WR +D N ++ + G S + ++P S + +Y CT
Sbjct: 3822 TLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSG--SLVIISP-SVDDTATYECTV 3878
Query: 98 TCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDH 157
T + ++ + + + P + + P + C+ + V PF + G
Sbjct: 3879 TNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGV-PFPSIHWTK-NGIR 3936
Query: 158 LMKSQEFLEDADRKSLETKSLEVT----FTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQA 213
L+ + ++E + ++ +T V + LH+ E P ++
Sbjct: 3937 LLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEP---PVIQPQ 3993
Query: 214 VKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDN----GNLQH 269
EL V ++ NP + + C + G P+P I W K+ N G
Sbjct: 3994 PSELHVILN--------NP---------ILLPCEATGTPSPFITWQKEGINVNTSGRNHA 4036
Query: 270 LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSV 329
+ + L + ED+G Y+C N G +++L VQ P + +
Sbjct: 4037 VLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPI 4096
Query: 330 TVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKAL 389
T+SC+ + P D + G I+E+I + L + SL++ F+ D G
Sbjct: 4097 TLSCEADGLPPPDITWHK--DGRAIVESIR------QRVLSSGSLQIAFVQP-GDAG--- 4144
Query: 390 VCQAKLHIDDMEFEPKQRQSTQT-LYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP 448
H M ST T L V+V PR + + E S + C++ G P
Sbjct: 4145 ------HYTCMAANVAGSSSTSTKLTVHVPPRIRST--EGHYTVNENSQAILPCVADGIP 4196
Query: 449 APKILWSRQ-------LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVE 501
P I W + L +P E L L + +EDSG Y C N AG V
Sbjct: 4197 TPAINWKKDNVLLANLLGKYTAEPYGE---LILENVVLEDSGFYTCVANNAAGEDTHTVS 4253
Query: 502 LIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDG- 559
L + V P T P + S+ +G+ + +SC +P + S++G
Sbjct: 4254 LTVHVLP---TFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGH 4310
Query: 560 -AYTIRKAQLKDAGVYECESKNKVG 583
I + +D+G Y C ++N VG
Sbjct: 4311 SELVIERVSKEDSGTYVCTAENSVG 4335
Score = 83.6 bits (205), Expect = 5e-16
Identities = 138/589 (23%), Positives = 221/589 (37%), Gaps = 82/589 (13%)
Query: 39 IGDSVSLTCSTTGCESPFFSWRTQ---IDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
+G++V L C+ G +P W I S ++ STL + + Y C
Sbjct: 3260 LGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTC 3319
Query: 96 TATCESRKLEKGIQVEIYSFP-----KDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEI 150
AT + + ++ + +Y P KD L ++ I ++C P +I
Sbjct: 3320 VATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTS--INIECRATGTPP---PQI 3374
Query: 151 DLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTV 210
+ LK + + R + + + V + V + +D
Sbjct: 3375 NWLKNGLPLPLSSHI----RLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHY---- 3426
Query: 211 RQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHL 270
LQV+ P + +G S +M C ++G PAP + W L +G L
Sbjct: 3427 -----NLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAW---LRDGQPLGL 3478
Query: 271 SGNAT-------LTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR---DPEIEMS 320
+ T L L+ EDSG Y C N G+ K L V P E E
Sbjct: 3479 DAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI 3538
Query: 321 GGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTD-MKSLENKSLEMTFI 379
+VN + + ++C + S P ++ T +++ L TD +++L +
Sbjct: 3539 SVIVN-NPLELTC-IASGIPAPKM--------TWMKDGRPLPQTDQVQTLGGGEVLRIST 3588
Query: 380 PTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVA----PRDTTVLVSPSSILEEG 435
+EDTG+ C A D + E R N+A PRD TVL
Sbjct: 3589 AQVEDTGR-YTCLASSPAGDDDKEYLVRVHVPP---NIAGTDEPRDITVL--------RN 3636
Query: 436 SSVNMTCLSQGFPAPKILWSRQLPNGE-------LQPLSENATLTLISTKMEDSGVYLCE 488
V + C S P P I W R NGE ++ LS L + + + D+ Y C
Sbjct: 3637 RQVTLECKSDAVPPPVITWLR---NGERLQATPRVRILSGGRYLQINNADLGDTANYTCV 3693
Query: 489 GINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAE 548
N AG++ +E L + V P +IK S + + ++ C VP I +K
Sbjct: 3694 ASNIAGKTTREFILTVNV-PPNIK-GGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGA 3751
Query: 549 --TGDTVLKSI--DGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
G+ SI +G I+ A + D G Y C + N G+ R + L V
Sbjct: 3752 VLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV 3800
Score = 82.4 bits (202), Expect = 1e-15
Identities = 96/417 (23%), Positives = 183/417 (43%), Gaps = 53/417 (12%)
Query: 221 ISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK---LDNGNLQHLSGNA-TL 276
+SPK I VN ++T+ C + +P+ + W K L + + +++ N TL
Sbjct: 2679 LSPKEVKIKVN--------NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTL 2730
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLV----NGSSVTVS 332
+ ++ D+G Y C N+ G++ + ++ +Q P ++ G ++ NG + V
Sbjct: 2731 QIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVI 2790
Query: 333 CKVP-SVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSL-----EMTFIPT--IED 384
P S+Y E T+ + +D + +K L + IP +ED
Sbjct: 2791 INNPISLY----CETNAAPPPTLT----WYKDGHPLTSSDKVLILPGGRVLQIPRAKVED 2842
Query: 385 TGK-ALVCQAKLHIDDMEFEPKQRQSTQTLYVNV-APRDTTVLVSPSSILEEGSSVNMTC 442
G+ V + D ++++ + N P + TVLV+ S+++E C
Sbjct: 2843 AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIE--------C 2894
Query: 443 LSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRK 498
LS G PAP+ W + L + + LS L +++T++ D G Y+C N AG ++K
Sbjct: 2895 LSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKK 2954
Query: 499 EVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLK 555
L + V P I + + +V + + ++C P +W+ ++ + L
Sbjct: 2955 YFNLNVHVPPSVIGPKS-ENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTL- 3012
Query: 556 SIDGAYTIR--KAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVL 610
+ G T++ +A++ D G Y C + N+ G + +L V + KD+ S L V+
Sbjct: 3013 IVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVV 3069
Score = 79.7 bits (195), Expect = 8e-15
Identities = 119/535 (22%), Positives = 208/535 (38%), Gaps = 55/535 (10%)
Query: 79 TLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCS 138
+L + V F + Y C + E + + + PK + + G +++ CS
Sbjct: 575 SLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCS 634
Query: 139 VADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAK 198
A YP ++ + + F+ + R + + +D G + C A
Sbjct: 635 -ATGYPKPKIAWTV--------NDMFIVGSHRYRMTSDGTLFIKNAAPKDAG-IYGCLAS 684
Query: 199 LHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW 258
+S T +Q L+ +PK V+ L G M C + G+P P++ W
Sbjct: 685 ------NSAGTDKQN-STLRYIEAPKLMVVQSELLVAL--GDITVMECKTSGIPPPQVKW 735
Query: 259 SK-KLDNGNLQHLSGNATLTLIAMRME---DSGIYVCEGVNLIGKNRKEVELIVQAFPRD 314
K L+ L + L L+ ++ D+G Y C +N G+ ++ L V + P
Sbjct: 736 FKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVF 795
Query: 315 PEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSL 374
+ + GS+VT+ C V YP ++ L I F + S+
Sbjct: 796 IQEPADVSMEIGSNVTLPCYVQG-YPEPTIKWRRLDNMPI-----FSRPFSVSSISQLRT 849
Query: 375 EMTFIPTIEDTGKAL-VCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPS-SIL 432
FI + + K +C+A + +F Q ++T T+ VAP + +SPS + +
Sbjct: 850 GALFILNLWASDKGTYICEA-----ENQFGKIQSETTVTVTGLVAP---LIGISPSVANV 901
Query: 433 EEGSSVNMTC-LSQGFPAPKILW---SRQLPNGELQPLSENATLTLISTKMEDSGVYLCE 488
EG + + C L G P P+ W S L + + +L + +++D G Y C
Sbjct: 902 IEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCV 961
Query: 489 GINQAGRSRKEVELIIQVTPKDIKLTAFPSESVK---EGDTVIISCTCGNVPETWIILKK 545
N AG + K +++ V P T + + EG V + C P+ +I K
Sbjct: 962 ASNVAGTNNKTTSVVVHVLP-----TIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSK 1016
Query: 546 KAETGDTVLKSI----DGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGR 596
K E T DG+ + +++G Y C + N G R + L V R
Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVR 1071
Score = 79.0 bits (193), Expect = 1e-14
Identities = 89/383 (23%), Positives = 152/383 (39%), Gaps = 34/383 (8%)
Query: 222 SPKNTVISVNPSTKLQEGGSVTMTCSSEGL-PAPEIFWSKKLDNGNLQHL--SGNATLTL 278
+PK T+ P LQ G + CS + L P F + G Q+L S + L +
Sbjct: 430 APKVTMPEKTPGYYLQPG---QIPCSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDI 486
Query: 279 IAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSV 338
+ + D G Y C V+ G R + V P ++ + + G ++C + S
Sbjct: 487 AKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISA 546
Query: 339 YPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHID 398
+ L + ++ E +++L N SLE+ + D G+ C
Sbjct: 547 VDYN------LTWQRNDRDVRLAEPARIRTLANLSLELKSV-KFNDAGE-YHCMV----- 593
Query: 399 DMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ- 457
+ S ++++ V ++ + GS V++ C + G+P PKI W+
Sbjct: 594 ----SSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVND 649
Query: 458 --LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTA 515
+ ++ + TL + + +D+G+Y C N AG ++ L P KL
Sbjct: 650 MFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAP---KLMV 706
Query: 516 FPSE-SVKEGDTVIISCTCGNVPETWI-ILKKKAETGDTVLKSID---GAYTIRKAQLKD 570
SE V GD ++ C +P + K E + ID G I++ Q D
Sbjct: 707 VQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLD 766
Query: 571 AGVYECESKNKVGSQLRSLTLDV 593
AG Y C + N+ G +TLDV
Sbjct: 767 AGDYTCVAINEAGRATGKITLDV 789
Score = 60.5 bits (145), Expect = 5e-09
Identities = 90/418 (21%), Positives = 158/418 (37%), Gaps = 42/418 (10%)
Query: 221 ISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLS-----GNAT 275
+S VI V + + G +TC + W + + L + N +
Sbjct: 516 VSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLS 575
Query: 276 LTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKV 335
L L +++ D+G Y C + G + V L VQ P+ + + GS V++ C
Sbjct: 576 LELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSA 635
Query: 336 PSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKL 395
YP ++ + DM + + MT T+ A
Sbjct: 636 TG-YPKPKIAWTV---------------NDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIY 679
Query: 396 HIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWS 455
+Q++ Y+ AP+ ++V ++ G M C + G P P++ W
Sbjct: 680 GCLASNSAGTDKQNSTLRYIE-APK--LMVVQSELLVALGDITVMECKTSGIPPPQVKWF 736
Query: 456 RQLPNGELQP---LSENATLTLIS---TKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK 509
+ + EL+P L + L L+ T+ D+G Y C IN+AGR+ ++ L + P
Sbjct: 737 KG--DLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPV 794
Query: 510 DIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKK--------KAETGDTVLKSIDGAY 561
I+ A S++ G V + C PE I ++ + + ++ + GA
Sbjct: 795 FIQEPA--DVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL 852
Query: 562 TIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIP 619
I D G Y CE++N+ G T+ V G SP + + L +P
Sbjct: 853 FILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLP 910
Score = 60.1 bits (144), Expect = 6e-09
Identities = 93/485 (19%), Positives = 185/485 (38%), Gaps = 57/485 (11%)
Query: 35 YLAQIGDSVSLTCSTTGCESPFFSWRTQ---IDSPLNGKVTNEGTTSTLTMNPVSFGNEH 91
Y+ + ++L+C G P +W I + +V + G+ + P G+
Sbjct: 4088 YVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQP---GDAG 4144
Query: 92 SYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEID 151
Y C A + ++ ++ P+ + + C VAD P +
Sbjct: 4145 HYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGIPTPAIN-- 4201
Query: 152 LLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVR 211
K D+++ + + + E + V+ED G C A E TV
Sbjct: 4202 -WKKDNVLLANLL----GKYTAEPYGELILENVVLEDSG-FYTCVANNAAGE--DTHTV- 4252
Query: 212 QAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWS--KKLDNGNLQH 269
L V++ P T + + S L +G + ++C + G+P P++ W+ + +
Sbjct: 4253 ----SLTVHVLPTFTELPGDVS--LNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDS 4306
Query: 270 LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVN---- 325
++G++ L + + EDSG YVC N +G V+ I + ++P + N
Sbjct: 4307 VNGHSELVIERVSKEDSGTYVCTAENSVGF----VKAIGFVYVKEPPVFKGDYPSNWIEP 4362
Query: 326 -GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIED 384
G + ++C+V P ++ + ++ ++ L N SL + T+ +
Sbjct: 4363 LGGNAILNCEVKGD-PTPTIQWNR-------KGVDIEISHRIRQLGNGSLAI--YGTVNE 4412
Query: 385 TGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLS 444
C A +E +++ + + L +++ G + + C +
Sbjct: 4413 DAGDYTCVATNEAGVVE---------RSMSLTLQSPPIITLEPVETVINAGGKIILNCQA 4463
Query: 445 QGFPAPKILWSRQ---LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVE 501
G P P I WSRQ + + + N +L + + ED+ + C N G V
Sbjct: 4464 TGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVP 4523
Query: 502 LIIQV 506
+I+QV
Sbjct: 4524 VIVQV 4528
Score = 58.5 bits (140), Expect = 2e-08
Identities = 118/598 (19%), Positives = 218/598 (36%), Gaps = 106/598 (17%)
Query: 43 VSLTCSTTGCESPFFSWRTQIDSPLNGK-----VTNEGTTSTLTMNPVSFGNEHSYLCTA 97
+ C G P W L G+ + +GT L + V+ + Y+C A
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHN-GRELTGREPGISILEDGTL--LVIASVTPYDNGEYICVA 1340
Query: 98 TCESRKLEKGIQVEIYSFP--KDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKG 155
E+ E+ ++++ P KD E + + + + C E++
Sbjct: 1341 VNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFC-----------EVEGTPS 1389
Query: 156 DHLMKSQEFLEDADRKSLET----KSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVR 211
+M ++ ++ + +++T K L++ F ED G+ C+A ++
Sbjct: 1390 PIIMWYKDNVQVTESSTIQTVNNGKILKL-FRATPEDAGRYS-CKAI-------NIAGTS 1440
Query: 212 QAVKELQVYISPKNTVISVNPSTKLQE--GGSVTMTCSSEGLPAPEIFWSKK-----LDN 264
Q + V + P T+I N ++ V + C +G P P+I W K L +
Sbjct: 1441 QKYFNIDVLVPP--TIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGD 1498
Query: 265 GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLV 324
N++ L L L R D G Y C N GK K+++L + P +
Sbjct: 1499 PNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPS----------I 1548
Query: 325 NGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIED 384
G +VT V ++ ++ LE E + L M I +D
Sbjct: 1549 KGGNVTTDISV------------------LINSLIKLE------CETRGLPMPAITWYKD 1584
Query: 385 TGKALVCQAKLHIDDMEFE--PKQRQSTQTLY------------------VNVAPRDTTV 424
+ L+ID ++ P+ + S Y V V P
Sbjct: 1585 GQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGN 1644
Query: 425 LVSP-SSILEEGSSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTKM 479
L +P + + S+ + C + G P+P + W + N ++ + L ++S +
Sbjct: 1645 LATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQE 1704
Query: 480 EDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISC-TCGNVPE 538
D G Y+C + AG + E+ + V P V + + + C G+ P
Sbjct: 1705 IDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPP 1764
Query: 539 T--WIILKKKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
T W+ + + D ++G I +AQ+ + G+Y C + N G + + V
Sbjct: 1765 TIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Score = 37.4 bits (85), Expect = 0.043
Identities = 34/142 (23%), Positives = 62/142 (43%), Gaps = 17/142 (11%)
Query: 464 QPLSENATLTLISTK--MEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESV 521
Q L E+A++ L K + D G Y C ++ AG R + + P I++ + +V
Sbjct: 474 QYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPN--NVTV 531
Query: 522 KEGDTVIISCTCGNVPE---TW------IILKKKAETGDTVLKSIDGAYTIRKAQLKDAG 572
G+ +++C + + TW + L + A S++ ++ + DAG
Sbjct: 532 TPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLE----LKSVKFNDAG 587
Query: 573 VYECESKNKVGSQLRSLTLDVQ 594
Y C ++ GS S+ L VQ
Sbjct: 588 EYHCMVSSEGGSSAASVFLTVQ 609
Score = 34.3 bits (77), Expect = 0.37
Identities = 24/106 (22%), Positives = 45/106 (42%), Gaps = 2/106 (1%)
Query: 33 SRYLAQIGDSVSLTCSTTGCESPFFSW-RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEH 91
S ++ +G + L C G +P W R +D ++ ++ G S V+ +
Sbjct: 4357 SNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVN-EDAG 4415
Query: 92 SYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKC 137
Y C AT E+ +E+ + + + S P + + AG I + C
Sbjct: 4416 DYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNC 4461
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 106 bits (264), Expect = 8e-23
Identities = 148/613 (24%), Positives = 254/613 (41%), Gaps = 81/613 (13%)
Query: 28 ETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSF 87
E + + + + +SL C SP +W +P + T + ++
Sbjct: 1353 EDSADEEVTVTVNNPISLICEALAFPSPNITWMKD-GAPFEASRNIQLLPGTHGLQILNA 1411
Query: 88 GNEHS--YLCTATCESRKLEKGIQVEIY---SFPKDPEIHLSGPLEA----GKPITVKC- 137
E + Y C T E + K VE+ S KD + G E +T++C
Sbjct: 1412 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECE 1471
Query: 138 SVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRA 197
S A P R D G + S + + L+ + +V+ D G+ L
Sbjct: 1472 SWAVPPPTIRWYKD---GQPVTPSSRLQVLGEGRLLQIQPTQVS------DSGRYLCVAT 1522
Query: 198 KLH-IDEMD-----SVPTVRQAVKEL----QVYISPKNTVISVNPSTKLQEGGSVTMTCS 247
+ D+ D VP + Q V + ++ + V ++ E + C
Sbjct: 1523 NVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1582
Query: 248 SEGLPAPEIFWSKK---LDNGN-LQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKE 303
+ +P P++ W ++ L G+ + L G L + +R E++G Y C+ N +G++
Sbjct: 1583 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1642
Query: 304 VELIVQAFP---RDPEIEMSGGLVNGSSVTVSCKVPSV-YPLDRLEIELLKGETILENIE 359
EL+V P D E + VN SS TVS + P++ P+ + + +
Sbjct: 1643 YELLVLTPPVILGDTEELVEEVTVNASS-TVSLQCPALGNPVPTIS-------WLQNGLP 1694
Query: 360 FLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAP 419
F ++ LE+ + + D + +C A E + + TL V V P
Sbjct: 1695 FSPSPRLQVLEDGQVLQVSTAEVADAA-SYMCVA-------ENQAGSAEKLFTLRVQVPP 1746
Query: 420 RDTTV-LVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGE-LQPLSENATLTL 474
R + L ++IL SSV++ C P P++ W S+ L GE + L TL L
Sbjct: 1747 RIAGLDLEQVTAILN--SSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQL 1804
Query: 475 ISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSES--VKEGDTVIISCT 532
++ DSG+Y CE +N AGR +K V+L + V P + P ++ V+ GD ++SC
Sbjct: 1805 GRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCE 1864
Query: 533 CGNVPE---TW------IILKKKAET--GDTVLKSIDGAYTIRKAQLKDAGVYECESKNK 581
+PE TW ++L ++ + G L+ I++AQ+ D G+Y C+ N
Sbjct: 1865 TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLE-------IQEAQVSDKGLYSCKVSNV 1917
Query: 582 VGSQLRSLTLDVQ 594
G +R+ TL VQ
Sbjct: 1918 AGEAVRTFTLTVQ 1930
Score = 94.0 bits (232), Expect = 4e-19
Identities = 126/573 (21%), Positives = 218/573 (38%), Gaps = 69/573 (12%)
Query: 43 VSLTCSTTGCESPFFSWR---TQIDSPLNG-KVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
V LTC +TG +P SW Q+ + +G +V+ G P+ G Y C+A
Sbjct: 2683 VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR---YTCSAR 2739
Query: 99 CESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHL 158
+ K + + + + P + A + + + C + + R I K
Sbjct: 2740 NSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGI---PRPTITWQK---- 2792
Query: 159 MKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQ 218
+ + L L + ED G L C AK + A+ + +
Sbjct: 2793 -EGLNVATGVSTQVLPGGQLRIAHASP-EDAGNYL-CIAK---------NSAGSAMGKTR 2840
Query: 219 VYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLT- 277
+ + + + P EG + C + G P P I W K D + G T+
Sbjct: 2841 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK--DGQPVSGAEGKFTIQP 2898
Query: 278 ---LIAMRME--DSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVS 332
L+ +E D+G Y C N +G+ R+ V L + P + L G + +
Sbjct: 2899 SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLR 2958
Query: 333 CKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQ 392
C P R+ + + E + E +L+ ++ ED+G VC
Sbjct: 2959 CAARGS-PTPRIGWTV-NDRPVTEGVS--EQDGGSTLQRAAVSR------EDSG-TYVCW 3007
Query: 393 AKLHIDDMEFEPKQRQSTQTLYVNVAP----RDTTVLVSPSSILEEGSSVNMTCLSQGFP 448
A+ + + Q+ ++V AP + LV P G S+ + C+ +G P
Sbjct: 3008 AENRVG-------RTQAVSFVHVKEAPVLQGEAFSYLVEPV-----GGSIQLDCVVRGDP 3055
Query: 449 APKILWSRQ---LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 505
P I W + L L+ +N +LT+ T+ +D+G Y C N+ G ++K V L++Q
Sbjct: 3056 VPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQ 3115
Query: 506 VTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDGAYT 562
P + +V+ GD V + C P W+ + + DG+
Sbjct: 3116 SAP--VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLW 3173
Query: 563 IRKAQLKDAGVYECESKNKVGSQLRSLTLDVQG 595
+ + DAG Y+C + N +GS L V+G
Sbjct: 3174 LENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3206
Score = 93.6 bits (231), Expect = 5e-19
Identities = 123/587 (20%), Positives = 217/587 (36%), Gaps = 76/587 (12%)
Query: 39 IGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTS--------TLTMNPVSFGNE 90
+ V LTC+ TG SP W V+ GT LT+ +
Sbjct: 800 VNTPVRLTCNATGAPSPTLMWLKD-----GNPVSPAGTPGLQVFPGGRVLTLASARASDS 854
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEI 150
Y C A + + + ++++ P L+ + A + + ++C
Sbjct: 855 GRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQ------------ 902
Query: 151 DLLKGDHLMKSQEFLEDADRKSLETK-SLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPT 209
H M D + LE + + ++ + + + V A + E +
Sbjct: 903 -----SHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAG 957
Query: 210 VRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKL-----DN 264
+ L V+++P + + T ++EG +++C G+P P+I W K +
Sbjct: 958 RSEKHYNLNVWVAPVFPLRESHTLT-VREGHPTSLSCECRGVPFPKISWRKDGQPLPGEG 1016
Query: 265 GNLQHLSGNATLTLIAM-RMEDSGIYVCEGVNLIGKNRKEVELIVQ-----AFPRDPEIE 318
LQH+S L + ++ G Y CE N++G + ++++L V A PR+P +
Sbjct: 1017 AGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQ 1076
Query: 319 MSGGLVNGSSVTVSC----KVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSL 374
+S +V T+ C K P +R G+ + + +SL +
Sbjct: 1077 VS--VVQDGVATLECNATGKPPPTVTWER------DGQPVGAELGLQLQNQGQSLHVERA 1128
Query: 375 EMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEE 434
+ + L +A+ + P + N+ T L SP ++L
Sbjct: 1129 QAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI----TAALHSPLTLL-- 1182
Query: 435 GSSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGI 490
C + G P P I W R P + L+ L + T+ +DSG+Y C
Sbjct: 1183 -------CEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS 1235
Query: 491 NQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKA 547
N+AG +R+ + + V P V +G T + C P+ TW +
Sbjct: 1236 NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 1295
Query: 548 ETGDTVLKSIDGA-YTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
GD S DG + +A L AG Y C + N VG + + L V
Sbjct: 1296 ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV 1342
Score = 93.2 bits (230), Expect = 7e-19
Identities = 129/606 (21%), Positives = 240/606 (39%), Gaps = 60/606 (9%)
Query: 31 PESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNE-GTTSTLTMNPVSFGN 89
P+ L ++GD L+C T P +W + + T L + +
Sbjct: 1847 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 1906
Query: 90 EHSYLCTATCESRKLEKGIQVEIYSFP--KDPEIHLSGPLEAGKPITVKCSVADVYPFDR 147
+ Y C + + + + + + P ++P+ + AG P+ + C V+ V
Sbjct: 1907 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQV-AGSPLVLTCDVSGV---PA 1962
Query: 148 LEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCR---AKLHIDEM 204
+ LK DR +E+ ++ V+ G++ + R A+
Sbjct: 1963 PTVTWLK--------------DRMPVESSAVH----GVVSRGGRLQLSRLQPAQAGTYTC 2004
Query: 205 DSVPTVRQAVKE--LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK- 261
+ T +A K+ + V ++P+ V + EG V + C ++G P P++ W K
Sbjct: 2005 VAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDG 2064
Query: 262 ----LDNG-NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPE 316
D G +L+ +L L +R D+G Y C N G++ + + V P +
Sbjct: 2065 SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQ 2124
Query: 317 -IEMSGGLVN--GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKS 373
+ SG LV+ G VT+ C V P+ + LK L L + +
Sbjct: 2125 GADGSGTLVSRPGELVTMVCPVRGSPPI---HVSWLKDGLPLP----LSQRTLLHGSGHT 2177
Query: 374 LEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE 433
L ++ + + V + + D F TL V V P V ++
Sbjct: 2178 LRISKVQLADAGIFTCVAASPAGVADRNF---------TLQVQVPPVLEPVEFQNDVVVV 2228
Query: 434 EGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQA 493
GS V + C ++G P P + W + Q L + +L L + DSG Y C +++A
Sbjct: 2229 RGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEA 2288
Query: 494 GRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGNVPETWIILKKKAETGDT 552
G +R+ +L + + P I+ + P+E S+ G + + C P+ I K G
Sbjct: 2289 GEARRHFQLTV-MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK---DGQA 2344
Query: 553 VLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYF 612
+ + + + R +++DAG+Y C +++ G+ +S + VQ N P +V
Sbjct: 2345 LTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLA 2404
Query: 613 ASSLII 618
L++
Sbjct: 2405 PGQLVL 2410
Score = 86.3 bits (212), Expect = 8e-17
Identities = 142/599 (23%), Positives = 223/599 (37%), Gaps = 89/599 (14%)
Query: 20 AASQAFKIE--TTPESR-----YLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGK-- 70
+ S AF++E T P R + + L C G +P SWR PL+ +
Sbjct: 2469 STSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD-RVPLDPRSP 2527
Query: 71 ---VTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPL 127
+ EG+ L + PV + YLC A+ + +G + + P + L
Sbjct: 2528 RFEILPEGS---LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTL 2584
Query: 128 EAGKPITVKCSVAD------VYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVT 181
A P + C + V+ D ++D L+ + L + +L +T
Sbjct: 2585 TAHTPALLPCEASGSPKPLVVWWKDGQKLDFR-----------LQQGAYRLLPSNALLLT 2633
Query: 182 FTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGS 241
P +D + E V +A + QV + T+ +
Sbjct: 2634 -APGPQDSAQF----------ECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAP 2682
Query: 242 VTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLI 297
V +TC S G+PAP + WSK G+ +S + L + +G Y C N
Sbjct: 2683 VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSA 2742
Query: 298 GKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILEN 357
G K V L VQA P + V V + C+ + R I K E
Sbjct: 2743 GVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGI---PRPTITWQK-----EG 2794
Query: 358 IEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV 417
+ + L L + + ED G L C AK L V V
Sbjct: 2795 LNVATGVSTQVLPGGQLRIAH-ASPEDAGNYL-CIAK-------NSAGSAMGKTRLVVQV 2845
Query: 418 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR--QLPNG-----ELQPLSENA 470
P L P EGS + C ++G P P I W + Q +G +QP E
Sbjct: 2846 PPVIENGL--PDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-- 2901
Query: 471 TLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVII 529
L + + + +D+G Y C N GR+R+ V L I V P T P + S++ GD + +
Sbjct: 2902 -LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP---VFTTLPGDRSLRLGDRLWL 2957
Query: 530 SCTCGNVPET---WIILKKKAETGDTVLKSIDGAYTIRKAQL--KDAGVYECESKNKVG 583
C P W + + G + DG T+++A + +D+G Y C ++N+VG
Sbjct: 2958 RCAARGSPTPRIGWTVNDRPVTEG---VSEQDGGSTLQRAAVSREDSGTYVCWAENRVG 3013
Score = 79.3 bits (194), Expect = 1e-14
Identities = 98/400 (24%), Positives = 157/400 (39%), Gaps = 50/400 (12%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDN-----GNLQHLS 271
L+V + P VN + + E SVT+ C + G+P P++ W K G +
Sbjct: 689 LKVLVPPNIEPGPVNKA--VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVD 746
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP-EIEMSGGLVNGSSVT 330
G L + ++ D+G Y C N+ G L V PR + G ++ + V
Sbjct: 747 GRV-LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVR 805
Query: 331 VSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALV 390
++C T++ +L+D + S F G+ L
Sbjct: 806 LTCNATGA-----------PSPTLM----WLKDGNPVSPAGTPGLQVF-----PGGRVLT 845
Query: 391 CQAKLHIDDMEFE-------PKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCL 443
+ D + + RQ L V++ P ++ S + E SV + C
Sbjct: 846 LASARASDSGRYSCVAVSAVGEDRQDV-VLQVHMPPSILGEELNVSVVANE--SVALECQ 902
Query: 444 SQGFPAPKILW---SRQL-PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKE 499
S P P + W R L P + ++ A L + + D+G Y CE +NQAGRS K
Sbjct: 903 SHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKH 962
Query: 500 VELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAE------TGDTV 553
L + V P L + +V+EG +SC C VP I +K + G
Sbjct: 963 YNLNVWVAPV-FPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQH 1021
Query: 554 LKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
+ ++ + +AQL G Y CE N VG+ + L L+V
Sbjct: 1022 VSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV 1061
Score = 77.8 bits (190), Expect = 3e-14
Identities = 99/396 (25%), Positives = 145/396 (36%), Gaps = 52/396 (13%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATL 276
LQV + P + + G V + C + G+P P + W K + Q L +L
Sbjct: 2208 LQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSL 2267
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSG-----GLVNGSSVTV 331
L A+ DSG Y C V+ G+ R+ +L V P IE SG L G+ + +
Sbjct: 2268 QLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM---EPPHIEDSGQPTELSLTPGAPMEL 2324
Query: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTD-MKSLENKSLEMTFIPTIEDTGKALV 390
C T NI + +D + LEN S T + + D G
Sbjct: 2325 LCDAQG---------------TPQPNITWHKDGQALTRLENNS-RATRVLRVRDAG-LYT 2367
Query: 391 CQAKLHIDDMEFEPKQR-QSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPA 449
C A+ +E + R Q+ + PR L +LE C + PA
Sbjct: 2368 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLE--------CSVEAEPA 2419
Query: 450 PKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 505
PKI W R + Q L L + DSG Y C N AG + + I
Sbjct: 2420 PKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIH 2479
Query: 506 VTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSI----DGAY 561
P + P+ +V T ++ C VP + +K D +G+
Sbjct: 2480 TVP--TIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSL 2537
Query: 562 TIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRE 597
I+ +DAG Y C + N GS D QGR+
Sbjct: 2538 RIQPVLAQDAGHYLCLASNSAGS-------DRQGRD 2566
Score = 77.4 bits (189), Expect = 4e-14
Identities = 133/589 (22%), Positives = 223/589 (37%), Gaps = 92/589 (15%)
Query: 31 PESRYLAQI-GDSVSLTCSTTGCESPFFSW---RTQIDSP-LNGKVTNEGTTSTLTMNPV 85
P++ ++Q+ G + LTC +G +P +W R ++S ++G V+ G + P
Sbjct: 1938 PKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPA 1997
Query: 86 SFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-----GKPITVKCSVA 140
G +Y C A + K V + P+ I SG G+ + + C
Sbjct: 1998 QAG---TYTCVAENTQAEARKDFVVAVLVAPR---IRSSGVAREHHVLEGQEVRLDCEAD 2051
Query: 141 DVYPFDR--LEIDLLKGDHLMKSQEFLEDADRKSLETKSLE---------VTFTPVIEDI 189
P D L+ G + F D SL K L V P ED
Sbjct: 2052 GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG--SLVLKGLRASDAGAYTCVAHNPAGED- 2108
Query: 190 GKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSE 249
A+LH + PT++Q T++S + G VTM C
Sbjct: 2109 -------ARLHTVNVLVPPTIKQGA-------DGSGTLVS-------RPGELVTMVCPVR 2147
Query: 250 GLPAPEIFWSKK-----LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV 304
G P + W K L L H SG+ TL + +++ D+GI+ C + G +
Sbjct: 2148 GSPPIHVSWLKDGLPLPLSQRTLLHGSGH-TLRISKVQLADAGIFTCVAASPAGVADRNF 2206
Query: 305 ELIVQAFPRDPEIEMSGG--LVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLE 362
L VQ P +E +V GS V + C+ V PL L + GE +L + LE
Sbjct: 2207 TLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGV-PLP-LVSWMKDGEPLLS--QSLE 2262
Query: 363 DTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDT 422
SL+ +++ T + +A+ H EP ++ + + T
Sbjct: 2263 QG--PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP--------HIEDSGQPT 2312
Query: 423 TVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDS 482
+ ++P G+ + + C +QG P P I W + +G+ EN + ++ D+
Sbjct: 2313 ELSLTP------GAPMELLCDAQGTPQPNITWHK---DGQALTRLENNSRATRVLRVRDA 2363
Query: 483 GVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---T 539
G+Y C + AG K + +Q P + +++ C+ P T
Sbjct: 2364 GLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT 2423
Query: 540 W----IILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGS 584
W I+L++ A T ++ D+G Y C ++N GS
Sbjct: 2424 WHRDGIVLQEDAH---TQFPERGRFLQLQALSTADSGDYSCTARNAAGS 2469
Score = 75.1 bits (183), Expect = 2e-13
Identities = 95/418 (22%), Positives = 160/418 (38%), Gaps = 59/418 (14%)
Query: 212 QAVKELQVYISPKNTVISVNPSTKL--QEGGSVTMTCSSEGLPAPEIFWSKK----LDNG 265
Q ++ Q+ + T+ N + ++ E V + C + G+P P I W K +
Sbjct: 297 QQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST 356
Query: 266 NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGG--- 322
+ + G L L + D+G+Y C+ N +G K L V P IE +GG
Sbjct: 357 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV---PPTIEGAGGRPY 413
Query: 323 ---LVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFI 379
V G V + C V +P L +G + E+ E +TD L +S
Sbjct: 414 VVKAVAGRPVALEC-VARGHPSPTLSWHH-EGLPVAESNESRLETDGSVLRLES------ 465
Query: 380 PTIEDTGK-ALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSV 438
P +G + V + +++ + + Q L + TT++ G +
Sbjct: 466 PGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV---------GQPL 516
Query: 439 NMTCLSQGFPAPKILWSRQLPNGE-------LQPLSENATLTLISTKMEDSGVYLCEGIN 491
+ C + G P P I W L NG +Q S+ TL + +++ SG++ C+ N
Sbjct: 517 ELPCQASGSPVPTIQW---LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATN 573
Query: 492 QAGRSRKEVELII--QVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKK--- 546
+AG + EVE+ + + P +++ E + + V W K
Sbjct: 574 EAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLV 633
Query: 547 -----------AETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
TG V S+ I K L+D G+Y C + N G R + L V
Sbjct: 634 EGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKV 691
Score = 74.7 bits (182), Expect = 2e-13
Identities = 124/578 (21%), Positives = 212/578 (36%), Gaps = 88/578 (15%)
Query: 40 GDSVSLTCSTTGCESPFFSW-RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
G+ V++ C G SW + + PL+ + G+ TL ++ V + + C A
Sbjct: 2137 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2196
Query: 99 CESRKLEKG--IQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGD 156
+ ++ +QV++ + E + G + + C V P + +K
Sbjct: 2197 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGV-PLPL--VSWMKDG 2253
Query: 157 HLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKE 216
+ SQ LE LE + T + + R + M+ P + + +
Sbjct: 2254 EPLLSQS-LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEP-PHIEDSGQP 2311
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATL 276
++ ++P G + + C ++G P P I W K D L L N+
Sbjct: 2312 TELSLTP---------------GAPMELLCDAQGTPQPNITWHK--DGQALTRLENNSRA 2354
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQA-----FPRDPEIEMSGGLVNGSSVTV 331
T + +R+ D+G+Y C + G K + VQA PR P + GL G V +
Sbjct: 2355 TRV-LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVV--GLAPGQLV-L 2410
Query: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC 391
C V + P ++ + I ED + E G+ L
Sbjct: 2411 ECSVEAE-PAPKITWHR-------DGIVLQEDAHTQFPER--------------GRFLQL 2448
Query: 392 QAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMT----CLSQGF 447
QA D ++ R + + V TV S SVN T C + G
Sbjct: 2449 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 2508
Query: 448 PAPKILWSR-QLPNGELQPLSE---NATLTLISTKMEDSGVYLCEGINQAGRSRKEVEL- 502
PAP + W + ++P P E +L + +D+G YLC N AG R+ +L
Sbjct: 2509 PAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR 2568
Query: 503 -----IIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSI 557
I +P ++ LTA ++ C P+ ++ K + D L+
Sbjct: 2569 VLEPPAIAPSPSNLTLTAH--------TPALLPCEASGSPKPLVVWWKDGQKLDFRLQ-- 2618
Query: 558 DGAYTIRKAQL--------KDAGVYECESKNKVGSQLR 587
GAY + + +D+ +EC N+VG R
Sbjct: 2619 QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHR 2656
Score = 71.6 bits (174), Expect = 2e-12
Identities = 134/596 (22%), Positives = 220/596 (36%), Gaps = 97/596 (16%)
Query: 36 LAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNG----KVTNEGTTSTLTMNPVSFGNEH 91
L G V L C T+G +P W L G +V +G +T + V G+E
Sbjct: 228 LGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV--GDEG 285
Query: 92 SYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEID 151
Y C A + + + Q+ +++ P + G E G+ ++ D L +
Sbjct: 286 RYQCVAFSPAGQQARDFQLRVHAPPT-----IWGSNETGEVAVME---------DHL-VQ 330
Query: 152 LLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDI--GKVLVCRAKLHIDEMDSVPT 209
LL + + D L T S +V +T + G+ A ++ + +
Sbjct: 331 LLCEARGVPTPNITWFKDGALLPT-STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 389
Query: 210 VRQAVKELQVYISPKNTVISVNPST-KLQEGGSVTMTCSSEGLPAPEIFWSKK----LDN 264
+ L VY+ P P K G V + C + G P+P + W + ++
Sbjct: 390 AAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAES 449
Query: 265 GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLV 324
+ + + L L + SG+Y C + G+ + + VQ P++ ++ GL
Sbjct: 450 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV---PPQLLVAEGL- 505
Query: 325 NGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIED 384
VT P LE+ + + I++L++ P E
Sbjct: 506 --GQVTTIVGQP-------LELPCQASGSPVPTIQWLQNGR--------------PAEEL 542
Query: 385 TGKALVCQAK-LHIDDMEFEPKQRQSTQ-TLYVNVAPRDTTVLV----SPSSI------- 431
G + Q LHID +E + + Q T A + V V +P +
Sbjct: 543 AGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQY 602
Query: 432 ---LEEGSSVNMTC---------------LSQGFPAPKILWSRQLPNGELQPLSENATLT 473
E SS C L +G+ +P LW P G S L
Sbjct: 603 HWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE--PTGIPVAYSLPPPLQ 660
Query: 474 LISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFP-SESVKEGDTVIISCT 532
+ + D G+Y C N AG S++EV L + V P + P +++V E +V + C
Sbjct: 661 IEKVDLRDEGIYTCAATNLAGESKREVALKVLVPP---NIEPGPVNKAVLENASVTLECL 717
Query: 533 CGNVPE---TWIILKKKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGS 584
VP +W + + V S+DG I +AQL DAG Y C + N GS
Sbjct: 718 ASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS 773
Score = 70.5 bits (171), Expect = 5e-12
Identities = 124/580 (21%), Positives = 222/580 (38%), Gaps = 63/580 (10%)
Query: 41 DSVSLTCSTTGCESPFFSWRTQIDSPLNGK--VTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
+SV+L C + P SW PL + V + L ++ + Y C A
Sbjct: 895 ESVALECQSHAMPPPVLSWWKD-GRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEAL 953
Query: 99 CESRKLEKGIQVEIYSFPKDP--EIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGD 156
++ + EK + ++ P P E H E G P ++ C V PF ++
Sbjct: 954 NQAGRSEKHYNLNVWVAPVFPLRESHTLTVRE-GHPTSLSCECRGV-PFPKIS------- 1004
Query: 157 HLMKSQEFLEDADRKSLETKSLE-VTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVK 215
+ +D E L+ V+ + +G+ + + + E +V
Sbjct: 1005 -------WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDL 1057
Query: 216 ELQVYISPKNTVISVNPS-TKLQEGGSVTMTCSSEGLPAPEIFWSKKLD----NGNLQHL 270
+L+V++ P+ P+ + + G T+ C++ G P P + W + LQ
Sbjct: 1058 QLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQ 1117
Query: 271 SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR-----DPEIEMSGGLVN 325
+ +L + + +G Y C NL G+ ++ EL V P DP ++ L
Sbjct: 1118 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAAL-- 1175
Query: 326 GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDT 385
S +T+ C+ + P I +GE E + EDT + + L+MT T E
Sbjct: 1176 HSPLTLLCEAMGIPPP---AIRWFRGE---EPVSPGEDTYLLA-GGWMLKMT--QTQEQD 1226
Query: 386 GKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQ 445
C A E ++ S + L V P + + +G + ++ C
Sbjct: 1227 SGLYSCLASNEAG----EARRNFSVEVL---VPPSIENEDLEEVIKVLDGQTAHLMCNVT 1279
Query: 446 GFPAPKILW---SRQLPNGELQPLS-ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVE 501
G P PK+ W R L G+ +S + L ++ + +G Y C N G K +
Sbjct: 1280 GHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQ 1339
Query: 502 LIIQVTPKDI---KLTAFPSESVKEGDTVIISCTCGNVPETWIILKK-----KAETGDTV 553
L + + P + + +A +V + + + C P I K +A +
Sbjct: 1340 LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL 1399
Query: 554 LKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
L G I AQ +DAG Y C N++G +++ ++V
Sbjct: 1400 LPGTHG-LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV 1438
Score = 66.6 bits (161), Expect = 7e-11
Identities = 87/373 (23%), Positives = 145/373 (38%), Gaps = 48/373 (12%)
Query: 228 ISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNG-------NLQHLSGNATLTLIA 280
++VN S+ +V++ C + G P P I W L NG LQ L L +
Sbjct: 1664 VTVNASS------TVSLQCPALGNPVPTISW---LQNGLPFSPSPRLQVLEDGQVLQVST 1714
Query: 281 MRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP--EIEMSGGLVNGSSVTVSCKVPSV 338
+ D+ Y+C N G K L VQ PR ++E ++N SSV++ C V
Sbjct: 1715 AEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN-SSVSLPC---DV 1770
Query: 339 YPLDRLEIELLKGETIL---ENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKL 395
+ E+ K L E + L T L L + + T E A Q +
Sbjct: 1771 HAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLV 1830
Query: 396 HIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWS 455
+ + P RQ+ + P+D ++ G ++C + P P + W
Sbjct: 1831 QLSVL-VPPAFRQAPR------GPQDAV-------LVRVGDKAVLSCETDALPEPTVTWY 1876
Query: 456 RQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDI 511
+ + Q L L + ++ D G+Y C+ N AG + + L +QV P
Sbjct: 1877 KDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQV-PPTF 1935
Query: 512 KLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDT-VLKSIDGAYTIRKAQ 567
+ + S G ++++C VP TW+ + E+ + S G + + Q
Sbjct: 1936 ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQ 1995
Query: 568 LKDAGVYECESKN 580
AG Y C ++N
Sbjct: 1996 PAQAGTYTCVAEN 2008
Score = 65.9 bits (159), Expect = 1e-10
Identities = 46/168 (27%), Positives = 74/168 (44%), Gaps = 9/168 (5%)
Query: 435 GSSVNMTCLSQGFPAPKILWSRQ----LPNG-ELQPLSENATLTLISTKMEDSGVYLCEG 489
G+ V + C + G P P++ W++ LP G LQ + L + + + D G Y C
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 291
Query: 490 INQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKK 546
+ AG+ ++ +L + P +V E V + C VP TW
Sbjct: 292 FSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL 351
Query: 547 AETGDTVLKSIDGAYT-IRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
T V+ + G + +AQ DAGVY C++ N VG+ ++ LDV
Sbjct: 352 LPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 399
Score = 58.9 bits (141), Expect = 1e-08
Identities = 91/422 (21%), Positives = 163/422 (38%), Gaps = 46/422 (10%)
Query: 210 VRQAVKELQVYISPKNTVI-----SVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK--- 261
V + K Q+ + T++ S + + +++ C + P+P I W K
Sbjct: 1331 VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 1390
Query: 262 -LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR----DPE 316
+ N+Q L G L ++ + ED+G Y C N +G+ K + V P DP
Sbjct: 1391 FEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPL 1450
Query: 317 IEMSGGLVN---GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKS 373
E+ V S++T+ C+ +V P + + T ++ L + + ++
Sbjct: 1451 GEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQ--- 1507
Query: 374 LEMTFIPT-IEDTGKAL-VCQAKLHIDDMEFEPK-------QRQSTQTLYVNVAPRDTTV 424
PT + D+G+ L V DD +F Q+ + + R+
Sbjct: 1508 ------PTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEA 1561
Query: 425 L--VSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTK 478
V+ + E + + C + P P + W R+ E+ L L + +
Sbjct: 1562 RGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVR 1621
Query: 479 MEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTC---GN 535
E++G Y C+ N+ G EL++ P + T E V + +S C GN
Sbjct: 1622 AENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN 1681
Query: 536 -VPE-TWIILKKKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLD 592
VP +W+ + DG + A++ DA Y C ++N+ GS + TL
Sbjct: 1682 PVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLR 1741
Query: 593 VQ 594
VQ
Sbjct: 1742 VQ 1743
Score = 57.4 bits (137), Expect = 4e-08
Identities = 79/372 (21%), Positives = 144/372 (38%), Gaps = 30/372 (8%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKK----LDNG-NLQHLSGNATLTLIAMRMEDSGIYVCEG 293
G V + C + G+P P++ W+K L G +LQ L + + D G Y C
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 291
Query: 294 VNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGET 353
+ G+ ++ +L V A P + GS+ T V D L L +
Sbjct: 292 FSPAGQQARDFQLRVHAPPT----------IWGSNETGEVAVME----DHLVQLLCEARG 337
Query: 354 I-LENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQT 412
+ NI + +D + K + ++ G+A A ++ +
Sbjct: 338 VPTPNITWFKDGALLPTSTKVVYTRGGRQLQ-LGRAQSSDAGVYTCKASNAVGAAEKATR 396
Query: 413 LYVNVAPRDTTVLVSPSSILE-EGSSVNMTCLSQGFPAPKILWSRQ-LP---NGELQPLS 467
L V V P P + G V + C+++G P+P + W + LP + E + +
Sbjct: 397 LDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLET 456
Query: 468 ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTV 527
+ + L L S SG+Y C + AG + + + +QV P+ + + G +
Sbjct: 457 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPL 516
Query: 528 IISCTCGNVPE---TWIILKKKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVG 583
+ C P W+ + AE V + G I +L +G++ C++ N+ G
Sbjct: 517 ELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 576
Query: 584 SQLRSLTLDVQG 595
+ + + V G
Sbjct: 577 TAGAEVEVSVHG 588
Score = 53.5 bits (127), Expect = 6e-07
Identities = 82/331 (24%), Positives = 131/331 (39%), Gaps = 60/331 (18%)
Query: 29 TTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFG 88
T P R L ++GD + L C+ G +P W T D P+ V+ + STL VS
Sbjct: 2942 TLPGDRSL-RLGDRLWLRCAARGSPTPRIGW-TVNDRPVTEGVSEQDGGSTLQRAAVSRE 2999
Query: 89 NEHSYLCTATCESR------------KLEKGIQVEIYSFPKDPEIHLSGPLEA-----GK 131
+ +Y+C A E+R K +Q E +S+ +P + G ++ G
Sbjct: 3000 DSGTYVCWA--ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP---VGGSIQLDCVVRGD 3054
Query: 132 PITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGK 191
P+ + D P L+G HL R L+ SL + T +D G+
Sbjct: 3055 PVPDIHWIKDGLP--------LRGSHL-----------RHQLQNGSLTIHRTER-DDAGR 3094
Query: 192 VLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTK-LQEGGSVTMTCSSEG 250
C A+ +EM K++ + + V V P ++ G V + C + G
Sbjct: 3095 YQ-CLAE---NEMG-------VAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATG 3143
Query: 251 LPAPEIFW---SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELI 307
P P I W + L + +L L + D+G Y C NL+G L+
Sbjct: 3144 EPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLV 3203
Query: 308 VQAFPRDPEIEMSGGLVNGSSVTVSCKVPSV 338
V+ P+ M+ G++NG V+ SV
Sbjct: 3204 VRGEPQGSWGSMT-GVINGRKFGVATLNTSV 3233
Score = 51.6 bits (122), Expect = 2e-06
Identities = 49/209 (23%), Positives = 81/209 (38%), Gaps = 27/209 (12%)
Query: 434 EGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLS---------ENATLTLISTKMEDSGV 484
E +SV + CL+ G P P + W + QP+S + L + ++ D+G
Sbjct: 708 ENASVTLECLASGVPPPDVSWFK-----GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGS 762
Query: 485 YLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILK 544
Y C N AG + L + V P+ + P V V ++C P ++
Sbjct: 763 YRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG-PVLVNTPVRLTCNATGAPSPTLMWL 821
Query: 545 KK----AETGDTVLKSIDG--AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ---- 594
K + G L+ G T+ A+ D+G Y C + + VG + + L V
Sbjct: 822 KDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 881
Query: 595 --GRENNKDYFSPELLVLYFASSLIIPAI 621
G E N + E + L S + P +
Sbjct: 882 ILGEELNVSVVANESVALECQSHAMPPPV 910
Score = 51.6 bits (122), Expect = 2e-06
Identities = 79/320 (24%), Positives = 123/320 (38%), Gaps = 69/320 (21%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWS---KKLDNGNLQHLSGN 273
L + + P T + + S +L G + + C++ G P P I W+ + + G + G
Sbjct: 2932 LTILVLPVFTTLPGDRSLRL--GDRLWLRCAARGSPTPRIGWTVNDRPVTEG-VSEQDGG 2988
Query: 274 ATLTLIAMRMEDSGIYVCEGVNLIGKNR-------KEVELIVQAFPRDPEIEMSGGLVNG 326
+TL A+ EDSG YVC N +G+ + KE ++Q +E GG +
Sbjct: 2989 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP-VLQGEAFSYLVEPVGGSIQL 3047
Query: 327 SSVTVSCKVPSVYPL-DRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDT 385
V VP ++ + D L L+G + L+N SL T T D
Sbjct: 3048 DCVVRGDPVPDIHWIKDGLP---LRGSHLRHQ-----------LQNGSL--TIHRTERDD 3091
Query: 386 GKALVCQAKLHIDDMEFEPKQ----RQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMT 441
C A+ ++M K QS V P+D TV G V +
Sbjct: 3092 AGRYQCLAE---NEMGVAKKVVILVLQSAPVFQVE--PQDMTV--------RSGDDVALR 3138
Query: 442 CLSQGFPAPKILWS------------RQLPNGELQPLSENATLTLISTKMEDSGVYLCEG 489
C + G P P I W R LP+G +L L + + D+G Y C
Sbjct: 3139 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDG---------SLWLENVETGDAGTYDCVA 3189
Query: 490 INQAGRSRKEVELIIQVTPK 509
N G + L+++ P+
Sbjct: 3190 HNLLGSATARAFLVVRGEPQ 3209
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/113 (27%), Positives = 52/113 (46%), Gaps = 7/113 (6%)
Query: 442 CLSQGFPAPKILWSRQLPNGEL---QP---LSENATLTLISTKMEDSGVYLCEGINQAGR 495
C + G P P++ W R+ P+ E QP + E +L L S DSG Y C+ N+ G
Sbjct: 24 CGTHGTPKPQVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 82
Query: 496 SRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAE 548
+ + +L++ V P + + S G ++ + C P I+ K A+
Sbjct: 83 TSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQ 135
Score = 42.4 bits (98), Expect = 0.001
Identities = 31/108 (28%), Positives = 45/108 (41%), Gaps = 18/108 (16%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLT-----LIAMRMEDSGIYV 290
L+ GG C + G P P++ W K + L G A L L ++ DSG Y
Sbjct: 19 LEAGG-----CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYE 73
Query: 291 CEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVN-----GSSVTVSC 333
C+ N +G + +L+V P I G N G S+T+ C
Sbjct: 74 CQATNEVGSTSRRAKLVVYV---PPSIREDGRKANVSGMAGQSLTLEC 118
Score = 32.7 bits (73), Expect = 1.1
Identities = 15/45 (33%), Positives = 21/45 (46%)
Query: 216 ELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK 260
+L VY+ P + G S+T+ C + G P PEI W K
Sbjct: 88 KLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLK 132
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 106 bits (264), Expect = 8e-23
Identities = 136/631 (21%), Positives = 231/631 (36%), Gaps = 115/631 (18%)
Query: 15 LWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNE 74
+W++ + I T+ S++ +Q G V ++CS +G +P SW + + +
Sbjct: 483 VWLLVREAPQVSIHTS--SQHFSQ-GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV 539
Query: 75 GTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPIT 134
TL + V+ + +Y C AT E ++ + + P ++ + G+
Sbjct: 540 DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 599
Query: 135 VKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLV 194
+ C + V P R LE+ P GK+ +
Sbjct: 600 LVCEASGVPP------------------------PRVIWYRGGLEMILAPEGSSSGKLRI 635
Query: 195 CRAKLHIDEMDSVPTVRQAVKEL-------QVYISPKNTVISVNPSTKLQEGGSVTMTCS 247
A+ E D+ +AV EL Q+ + + + ++ G S + C
Sbjct: 636 PAAQ----ERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACR 691
Query: 248 SEGLPAPEIFWSKK----------LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLI 297
+ G P P + W + G+ + L ++ ED YVCE N+
Sbjct: 692 ATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 751
Query: 298 GKNRKEVELIVQAFPRDPEIEMSGGLVN---GSSVTVSCKVPSVYPLDRLEIELLKGETI 354
GK + E LIV P+I S V G V++ C V + PL
Sbjct: 752 GKVQAEARLIVTGHA-PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH--------- 801
Query: 355 LENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQS---TQ 411
+L+D P + ++ LH+D E R S T
Sbjct: 802 -----WLKDGR--------------PLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN 842
Query: 412 T---------LYVNVAPRDTTVLVSPSS---ILEEGSSVNMTCLSQGFPAPKILWSRQL- 458
T L V V PR + P++ I EG ++ C++ G PAP I W+++
Sbjct: 843 TAGSQHRDVELVVQVPPR-----IHPTATHHITNEGVPASLPCVASGVPAPTITWTKETN 897
Query: 459 ---PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTA 515
G +S+ TL + +D+G Y+C N G S +E+ L + P+ I +
Sbjct: 898 ALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPR-IHMNG 956
Query: 516 FPSESV------KEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSI----DGAYTIRK 565
+ +V K G+ V + C P + K + + G+ + +
Sbjct: 957 SRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQ 1016
Query: 566 AQLKDAGVYECESKNKVGSQLRSLTLDVQGR 596
Q+ D+G YEC + N GS L VQGR
Sbjct: 1017 VQVGDSGHYECTASNPAGSASHRYVLGVQGR 1047
Score = 100 bits (250), Expect = 3e-21
Identities = 131/585 (22%), Positives = 224/585 (38%), Gaps = 59/585 (10%)
Query: 28 ETTPESRYLAQIGDSVSLTCSTTGCESPFF-----SWRTQIDSPLNGKVTNEGTTSTLTM 82
+ P G++ L+C G E+P+ WR S G+V S L +
Sbjct: 402 QLVPAPNVTVSPGETAVLSCRVLG-EAPYNLTWVRDWRVLPAS--TGRVAQLADLS-LEI 457
Query: 83 NPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGP-LEAGKPITVKCSVAD 141
+ + + Y C A+ + + + + P+ IH S G + V CS A
Sbjct: 458 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ-VSIHTSSQHFSQGVEVKVSCS-AS 515
Query: 142 VYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHI 201
YP + + + L++ R ++ + + ED G C+A
Sbjct: 516 GYPTPHISWS--------RESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS-CQAT--- 563
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK 261
+ V T ++ V +Y + +V +VN + G + C + G+P P + W +
Sbjct: 564 ---NEVGTDQETVT---LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR- 616
Query: 262 LDNGNLQHL-----SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPE 316
G L+ + S + L + A + D+G Y C VN +G E++L V P+ E
Sbjct: 617 ---GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTE 673
Query: 317 IEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEM 376
+ + G S ++C+ P + +G+ + +S + S +
Sbjct: 674 LPRDVTVELGRSALLACRATGRPPPT---VTWRRGDGQPLGLRLGAGRGSRSRQPDSGVL 730
Query: 377 TFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGS 436
F + VC+A+ ++ E + L V +P+ + EG
Sbjct: 731 FFESVAPEDQAPYVCEARNVFGKVQAEAR-------LIVTGHAPPQIASSAPTVRVLEGQ 783
Query: 437 SVNMTCLS-QGFPAPKILW---SRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQ 492
V++ C+ G P P+ W R LP G + + +L L E +G Y C N
Sbjct: 784 PVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNT 843
Query: 493 AGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAET--- 549
AG ++VEL++QV P+ I TA EG + C VP I K+
Sbjct: 844 AGSQHRDVELVVQVPPR-IHPTA-THHITNEGVPASLPCVASGVPAPTITWTKETNALTS 901
Query: 550 -GDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
G S +G I + +DAG Y C + N VG + + L V
Sbjct: 902 RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
Score = 44.7 bits (104), Expect = 3e-04
Identities = 35/135 (25%), Positives = 61/135 (45%), Gaps = 12/135 (8%)
Query: 467 SENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDT 526
S N++ ++ + G Y C +++AG R + ++++ P +L P+ +V G+T
Sbjct: 359 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP--QLVPAPNVTVSPGET 416
Query: 527 VIISC-TCGNVP------ETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESK 579
++SC G P W +L A TG V + D + I D G Y+C +
Sbjct: 417 AVLSCRVLGEAPYNLTWVRDWRVL--PASTG-RVAQLADLSLEISGIIPTDGGRYQCVAS 473
Query: 580 NKVGSQLRSLTLDVQ 594
N G S+ L V+
Sbjct: 474 NANGVTRASVWLLVR 488
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 106 bits (264), Expect = 8e-23
Identities = 148/613 (24%), Positives = 254/613 (41%), Gaps = 81/613 (13%)
Query: 28 ETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSF 87
E + + + + +SL C SP +W +P + T + ++
Sbjct: 2544 EDSADEEVTVTVNNPISLICEALAFPSPNITWMKD-GAPFEASRNIQLLPGTHGLQILNA 2602
Query: 88 GNEHS--YLCTATCESRKLEKGIQVEIY---SFPKDPEIHLSGPLEA----GKPITVKC- 137
E + Y C T E + K VE+ S KD + G E +T++C
Sbjct: 2603 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECE 2662
Query: 138 SVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRA 197
S A P R D G + S + + L+ + +V+ D G+ L
Sbjct: 2663 SWAVPPPTIRWYKD---GQPVTPSSRLQVLGEGRLLQIQPTQVS------DSGRYLCVAT 2713
Query: 198 KLH-IDEMD-----SVPTVRQAVKEL----QVYISPKNTVISVNPSTKLQEGGSVTMTCS 247
+ D+ D VP + Q V + ++ + V ++ E + C
Sbjct: 2714 NVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 2773
Query: 248 SEGLPAPEIFWSKK---LDNGN-LQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKE 303
+ +P P++ W ++ L G+ + L G L + +R E++G Y C+ N +G++
Sbjct: 2774 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 2833
Query: 304 VELIVQAFP---RDPEIEMSGGLVNGSSVTVSCKVPSV-YPLDRLEIELLKGETILENIE 359
EL+V P D E + VN SS TVS + P++ P+ + + +
Sbjct: 2834 YELLVLTPPVILGDTEELVEEVTVNASS-TVSLQCPALGNPVPTIS-------WLQNGLP 2885
Query: 360 FLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAP 419
F ++ LE+ + + D + +C A E + + TL V V P
Sbjct: 2886 FSPSPRLQVLEDGQVLQVSTAEVADAA-SYMCVA-------ENQAGSAEKLFTLRVQVPP 2937
Query: 420 RDTTV-LVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGE-LQPLSENATLTL 474
R + L ++IL SSV++ C P P++ W S+ L GE + L TL L
Sbjct: 2938 RIAGLDLEQVTAILN--SSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQL 2995
Query: 475 ISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSES--VKEGDTVIISCT 532
++ DSG+Y CE +N AGR +K V+L + V P + P ++ V+ GD ++SC
Sbjct: 2996 GRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCE 3055
Query: 533 CGNVPE---TW------IILKKKAET--GDTVLKSIDGAYTIRKAQLKDAGVYECESKNK 581
+PE TW ++L ++ + G L+ I++AQ+ D G+Y C+ N
Sbjct: 3056 TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLE-------IQEAQVSDKGLYSCKVSNV 3108
Query: 582 VGSQLRSLTLDVQ 594
G +R+ TL VQ
Sbjct: 3109 AGEAVRTFTLTVQ 3121
Score = 100 bits (250), Expect = 3e-21
Identities = 131/585 (22%), Positives = 224/585 (38%), Gaps = 59/585 (10%)
Query: 28 ETTPESRYLAQIGDSVSLTCSTTGCESPFF-----SWRTQIDSPLNGKVTNEGTTSTLTM 82
+ P G++ L+C G E+P+ WR S G+V S L +
Sbjct: 519 QLVPAPNVTVSPGETAVLSCRVLG-EAPYNLTWVRDWRVLPAS--TGRVAQLADLS-LEI 574
Query: 83 NPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGP-LEAGKPITVKCSVAD 141
+ + + Y C A+ + + + + P+ IH S G + V CS A
Sbjct: 575 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ-VSIHTSSQHFSQGVEVKVSCS-AS 632
Query: 142 VYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHI 201
YP + + + L++ R ++ + + ED G C+A
Sbjct: 633 GYPTPHISWS--------RESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS-CQAT--- 680
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK 261
+ V T ++ V +Y + +V +VN + G + C + G+P P + W +
Sbjct: 681 ---NEVGTDQETVT---LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR- 733
Query: 262 LDNGNLQHL-----SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPE 316
G L+ + S + L + A + D+G Y C VN +G E++L V P+ E
Sbjct: 734 ---GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTE 790
Query: 317 IEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEM 376
+ + G S ++C+ P + +G+ + +S + S +
Sbjct: 791 LPRDVTVELGRSALLACRATGRPPPT---VTWRRGDGQPLGLRLGAGRGSRSRQPDSGVL 847
Query: 377 TFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGS 436
F + VC+A+ ++ E + L V +P+ + EG
Sbjct: 848 FFESVAPEDQAPYVCEARNVFGKVQAEAR-------LIVTGHAPPQIASSAPTVRVLEGQ 900
Query: 437 SVNMTCLS-QGFPAPKILW---SRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQ 492
V++ C+ G P P+ W R LP G + + +L L E +G Y C N
Sbjct: 901 PVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNT 960
Query: 493 AGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAET--- 549
AG ++VEL++QV P+ I TA EG + C VP I K+
Sbjct: 961 AGSQHRDVELVVQVPPR-IHPTA-THHITNEGVPASLPCVASGVPAPTITWTKETNALTS 1018
Query: 550 -GDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
G S +G I + +DAG Y C + N VG + + L V
Sbjct: 1019 RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063
Score = 94.0 bits (232), Expect = 4e-19
Identities = 126/573 (21%), Positives = 218/573 (38%), Gaps = 69/573 (12%)
Query: 43 VSLTCSTTGCESPFFSWR---TQIDSPLNG-KVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
V LTC +TG +P SW Q+ + +G +V+ G P+ G Y C+A
Sbjct: 3874 VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR---YTCSAR 3930
Query: 99 CESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHL 158
+ K + + + + P + A + + + C + + R I K
Sbjct: 3931 NSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGI---PRPTITWQK---- 3983
Query: 159 MKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQ 218
+ + L L + ED G L C AK + A+ + +
Sbjct: 3984 -EGLNVATGVSTQVLPGGQLRIAHASP-EDAGNYL-CIAK---------NSAGSAMGKTR 4031
Query: 219 VYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLT- 277
+ + + + P EG + C + G P P I W K D + G T+
Sbjct: 4032 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK--DGQPVSGAEGKFTIQP 4089
Query: 278 ---LIAMRME--DSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVS 332
L+ +E D+G Y C N +G+ R+ V L + P + L G + +
Sbjct: 4090 SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLR 4149
Query: 333 CKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQ 392
C P R+ + + E + E +L+ ++ ED+G VC
Sbjct: 4150 CAARGS-PTPRIGWTV-NDRPVTEGVS--EQDGGSTLQRAAVSR------EDSG-TYVCW 4198
Query: 393 AKLHIDDMEFEPKQRQSTQTLYVNVAP----RDTTVLVSPSSILEEGSSVNMTCLSQGFP 448
A+ + + Q+ ++V AP + LV P G S+ + C+ +G P
Sbjct: 4199 AENRVG-------RTQAVSFVHVKEAPVLQGEAFSYLVEPV-----GGSIQLDCVVRGDP 4246
Query: 449 APKILWSRQ---LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 505
P I W + L L+ +N +LT+ T+ +D+G Y C N+ G ++K V L++Q
Sbjct: 4247 VPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQ 4306
Query: 506 VTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDGAYT 562
P + +V+ GD V + C P W+ + + DG+
Sbjct: 4307 SAP--VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLW 4364
Query: 563 IRKAQLKDAGVYECESKNKVGSQLRSLTLDVQG 595
+ + DAG Y+C + N +GS L V+G
Sbjct: 4365 LENVETGDAGTYDCVAHNLLGSATARAFLVVRG 4397
Score = 93.6 bits (231), Expect = 5e-19
Identities = 123/587 (20%), Positives = 217/587 (36%), Gaps = 76/587 (12%)
Query: 39 IGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTS--------TLTMNPVSFGNE 90
+ V LTC+ TG SP W V+ GT LT+ +
Sbjct: 1991 VNTPVRLTCNATGAPSPTLMWLKD-----GNPVSPAGTPGLQVFPGGRVLTLASARASDS 2045
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEI 150
Y C A + + + ++++ P L+ + A + + ++C
Sbjct: 2046 GRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQ------------ 2093
Query: 151 DLLKGDHLMKSQEFLEDADRKSLETK-SLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPT 209
H M D + LE + + ++ + + + V A + E +
Sbjct: 2094 -----SHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAG 2148
Query: 210 VRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKL-----DN 264
+ L V+++P + + T ++EG +++C G+P P+I W K +
Sbjct: 2149 HSEKHYNLNVWVAPVFPLRESHTLT-VREGHPTSLSCECRGVPFPKISWRKDGQPLPGEG 2207
Query: 265 GNLQHLSGNATLTLIAM-RMEDSGIYVCEGVNLIGKNRKEVELIVQ-----AFPRDPEIE 318
LQH+S L + ++ G Y CE N++G + ++++L V A PR+P +
Sbjct: 2208 AGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQ 2267
Query: 319 MSGGLVNGSSVTVSC----KVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSL 374
+S +V T+ C K P +R G+ + + +SL +
Sbjct: 2268 VS--VVQDGVATLECNATGKPPPTVTWER------DGQPVGAELGLQLQNQGQSLHVERA 2319
Query: 375 EMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEE 434
+ + L +A+ + P + N+ T L SP ++L
Sbjct: 2320 QAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI----TAALHSPLTLL-- 2373
Query: 435 GSSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGI 490
C + G P P I W R P + L+ L + T+ +DSG+Y C
Sbjct: 2374 -------CEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS 2426
Query: 491 NQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKA 547
N+AG +R+ + + V P V +G T + C P+ TW +
Sbjct: 2427 NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 2486
Query: 548 ETGDTVLKSIDGA-YTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
GD S DG + +A L AG Y C + N VG + + L V
Sbjct: 2487 ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV 2533
Score = 93.2 bits (230), Expect = 7e-19
Identities = 129/606 (21%), Positives = 240/606 (39%), Gaps = 60/606 (9%)
Query: 31 PESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNE-GTTSTLTMNPVSFGN 89
P+ L ++GD L+C T P +W + + T L + +
Sbjct: 3038 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 3097
Query: 90 EHSYLCTATCESRKLEKGIQVEIYSFP--KDPEIHLSGPLEAGKPITVKCSVADVYPFDR 147
+ Y C + + + + + + P ++P+ + AG P+ + C V+ V
Sbjct: 3098 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQV-AGSPLVLTCDVSGV---PA 3153
Query: 148 LEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCR---AKLHIDEM 204
+ LK DR +E+ ++ V+ G++ + R A+
Sbjct: 3154 PTVTWLK--------------DRMPVESSAVH----GVVSRGGRLQLSRLQPAQAGTYTC 3195
Query: 205 DSVPTVRQAVKE--LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK- 261
+ T +A K+ + V ++P+ V + EG V + C ++G P P++ W K
Sbjct: 3196 VAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDG 3255
Query: 262 ----LDNG-NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPE 316
D G +L+ +L L +R D+G Y C N G++ + + V P +
Sbjct: 3256 SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQ 3315
Query: 317 -IEMSGGLVN--GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKS 373
+ SG LV+ G VT+ C V P+ + LK L L + +
Sbjct: 3316 GADGSGTLVSRPGELVTMVCPVRGSPPI---HVSWLKDGLPLP----LSQRTLLHGSGHT 3368
Query: 374 LEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE 433
L ++ + + V + + D F TL V V P V ++
Sbjct: 3369 LRISKVQLADAGIFTCVAASPAGVADRNF---------TLQVQVPPVLEPVEFQNDVVVV 3419
Query: 434 EGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQA 493
GS V + C ++G P P + W + Q L + +L L + DSG Y C +++A
Sbjct: 3420 RGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEA 3479
Query: 494 GRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGNVPETWIILKKKAETGDT 552
G +R+ +L + + P I+ + P+E S+ G + + C P+ I K G
Sbjct: 3480 GEARRHFQLTV-MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK---DGQA 3535
Query: 553 VLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYF 612
+ + + + R +++DAG+Y C +++ G+ +S + VQ N P +V
Sbjct: 3536 LTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLA 3595
Query: 613 ASSLII 618
L++
Sbjct: 3596 PGQLVL 3601
Score = 92.0 bits (227), Expect = 1e-18
Identities = 135/649 (20%), Positives = 248/649 (38%), Gaps = 99/649 (15%)
Query: 17 IMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLN-------G 69
I A A ++ P ++G S L C TG P +WR PL G
Sbjct: 778 IQLAVGHAPQLTELPRD-VTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRG 836
Query: 70 KVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVE---IYSFPKDPEIHLSGP 126
+ + + L V+ ++ Y+C E+R + +Q E I + P+I S P
Sbjct: 837 SRSRQPDSGVLFFESVAPEDQAPYVC----EARNVFGKVQAEARLIVTGHAPPQIASSAP 892
Query: 127 ---LEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFT 183
+ G+P+++ C V P L H +K L R S+
Sbjct: 893 TVRVLEGQPVSLPCIVLAGRP--------LPERHWLKDGRPLPPGSRHSIRADGSLHLDR 944
Query: 184 PVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVT 243
+ E G+ + V EL V + P+ + + T EG +
Sbjct: 945 ALQEHAGRYSCVATNTAGSQHRDV--------ELVVQVPPRIHPTATHHITN--EGVPAS 994
Query: 244 MTCSSEGLPAPEIFWSKKLD----NGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGK 299
+ C + G+PAP I W+K+ + G ++S TL + +D+G YVC N +G
Sbjct: 995 LPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGF 1054
Query: 300 NRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVS---------CKVPSVYPLDRLEIELLK 350
+ +E+ L V + GL+ S+ ++ + + P +
Sbjct: 1055 SSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVL 1114
Query: 351 GETILENIEFLEDTDMKSLENKSLEMTFI------PTIEDTGKALVCQAK-----LHIDD 399
G + ++ +K L ++L++ + P + + +V Q + +H
Sbjct: 1115 GVQVPPQVQ-PGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVHFAA 1173
Query: 400 MEFEPKQR---QSTQTLYVNVAPRDTTVLVSP-------SSILEE--GSSVNMTCLSQGF 447
+ R +++ + V+ + VL P S +LE G + ++ C ++G
Sbjct: 1174 IRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGT 1233
Query: 448 PAPKILWSRQLPNGEL---QP---LSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVE 501
P P++ W R+ P+ E QP + E +L L S DSG Y C+ N+ G + + +
Sbjct: 1234 PKPQVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAK 1292
Query: 502 LIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVL------- 554
L++ V P + + S G ++ + C P I+ K A+ L
Sbjct: 1293 LVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGW 1352
Query: 555 ----------KSIDGAYTIR--KAQLKDAGVYECESKNKVGSQLRSLTL 591
+ +D ++ + Q D+G+Y C ++N+ G+ R L
Sbjct: 1353 DLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHL 1401
Score = 91.3 bits (225), Expect = 3e-18
Identities = 97/389 (24%), Positives = 153/389 (39%), Gaps = 47/389 (12%)
Query: 228 ISVNPSTK-LQEGGSVTMTCSSEGLPAPEIFWSKK---LDNGNLQHLSGNATLTLIAMRM 283
+S++ S++ +G V ++CS+ G P P I WS++ L + H+ TL + +
Sbjct: 610 VSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAP 669
Query: 284 EDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDR 343
ED+G Y C+ N +G +++ V L P + + G + C+ V P
Sbjct: 670 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP-- 727
Query: 344 LEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFE 403
+ +G LE I E + L + + E C+A + D E
Sbjct: 728 -RVIWYRGG--LEMILAPEGSSSGKLRIPAAQ-------ERDAGTYTCRAVNELGDASAE 777
Query: 404 PKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL 463
Q + PRD TV E G S + C + G P P + W R G+
Sbjct: 778 I-QLAVGHAPQLTELPRDVTV--------ELGRSALLACRATGRPPPTVTWRR----GDG 824
Query: 464 QPLS--------------ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK 509
QPL ++ L S ED Y+CE N G+ + E LI+
Sbjct: 825 QPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP 884
Query: 510 DIKLTAFPSESVKEGDTVIISCTC---GNVPET-WIILKKKAETGDTVLKSIDGAYTIRK 565
++ P+ V EG V + C +PE W+ + G DG+ + +
Sbjct: 885 PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDR 944
Query: 566 AQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
A + AG Y C + N GSQ R + L VQ
Sbjct: 945 ALQEHAGRYSCVATNTAGSQHRDVELVVQ 973
Score = 86.3 bits (212), Expect = 8e-17
Identities = 94/393 (23%), Positives = 155/393 (39%), Gaps = 61/393 (15%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLT-----LIAMRMEDSGIYVCEG 293
G + ++ C + G P P++ W K + L G A L L ++ DSG Y C+
Sbjct: 1221 GENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQA 1280
Query: 294 VNLIGKNRKEVELIVQAFPRDPEIEMSGGLVN-----GSSVTVSCKVPSVYPLDRLEIEL 348
N +G + +L+V P I G N G S+T+ C +P+
Sbjct: 1281 TNEVGSTSRRAKLVVYV---PPSIREDGRKANVSGMAGQSLTLECDANG-FPVPE----- 1331
Query: 349 LKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFE-PKQR 407
I +L+D + + + + D G V +L + P+ +
Sbjct: 1332 ---------IVWLKDAQLVGVP-----LGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQ 1377
Query: 408 QSTQTLY-------VNVAPRDTTVLV-SPSSILEEGSS----------VNMTCLSQGFPA 449
+ LY A RD +LV +P S+L G++ V + C + G P
Sbjct: 1378 EGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPT 1437
Query: 450 PKILWSRQ----LPNG-ELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII 504
P++ W++ LP G LQ + L + + + D G Y C + AG+ ++ +L +
Sbjct: 1438 PQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV 1497
Query: 505 QVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDGAY 561
P +V E V + C VP TW T V+ + G
Sbjct: 1498 HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ 1557
Query: 562 T-IRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
+ +AQ DAGVY C++ N VG+ ++ LDV
Sbjct: 1558 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 1590
Score = 86.3 bits (212), Expect = 8e-17
Identities = 142/599 (23%), Positives = 223/599 (37%), Gaps = 89/599 (14%)
Query: 20 AASQAFKIE--TTPESR-----YLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGK-- 70
+ S AF++E T P R + + L C G +P SWR PL+ +
Sbjct: 3660 STSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD-RVPLDPRSP 3718
Query: 71 ---VTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPL 127
+ EG+ L + PV + YLC A+ + +G + + P + L
Sbjct: 3719 RFEILPEGS---LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTL 3775
Query: 128 EAGKPITVKCSVAD------VYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVT 181
A P + C + V+ D ++D L+ + L + +L +T
Sbjct: 3776 TAHTPALLPCEASGSPKPLVVWWKDGQKLDFR-----------LQQGAYRLLPSNALLLT 3824
Query: 182 FTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGS 241
P +D + E V +A + QV + T+ +
Sbjct: 3825 -APGPQDSAQF----------ECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAP 3873
Query: 242 VTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLI 297
V +TC S G+PAP + WSK G+ +S + L + +G Y C N
Sbjct: 3874 VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSA 3933
Query: 298 GKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILEN 357
G K V L VQA P + V V + C+ + R I K E
Sbjct: 3934 GVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGI---PRPTITWQK-----EG 3985
Query: 358 IEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV 417
+ + L L + + ED G L C AK L V V
Sbjct: 3986 LNVATGVSTQVLPGGQLRIAH-ASPEDAGNYL-CIAK-------NSAGSAMGKTRLVVQV 4036
Query: 418 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR--QLPNG-----ELQPLSENA 470
P L P EGS + C ++G P P I W + Q +G +QP E
Sbjct: 4037 PPVIENGL--PDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-- 4092
Query: 471 TLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVII 529
L + + + +D+G Y C N GR+R+ V L I V P T P + S++ GD + +
Sbjct: 4093 -LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP---VFTTLPGDRSLRLGDRLWL 4148
Query: 530 SCTCGNVPET---WIILKKKAETGDTVLKSIDGAYTIRKAQL--KDAGVYECESKNKVG 583
C P W + + G + DG T+++A + +D+G Y C ++N+VG
Sbjct: 4149 RCAARGSPTPRIGWTVNDRPVTEG---VSEQDGGSTLQRAAVSREDSGTYVCWAENRVG 4204
Score = 77.8 bits (190), Expect = 3e-14
Identities = 99/396 (25%), Positives = 145/396 (36%), Gaps = 52/396 (13%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATL 276
LQV + P + + G V + C + G+P P + W K + Q L +L
Sbjct: 3399 LQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSL 3458
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSG-----GLVNGSSVTV 331
L A+ DSG Y C V+ G+ R+ +L V P IE SG L G+ + +
Sbjct: 3459 QLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM---EPPHIEDSGQPTELSLTPGAPMEL 3515
Query: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTD-MKSLENKSLEMTFIPTIEDTGKALV 390
C T NI + +D + LEN S T + + D G
Sbjct: 3516 LCDAQG---------------TPQPNITWHKDGQALTRLENNS-RATRVLRVRDAG-LYT 3558
Query: 391 CQAKLHIDDMEFEPKQR-QSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPA 449
C A+ +E + R Q+ + PR L +LE C + PA
Sbjct: 3559 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLE--------CSVEAEPA 3610
Query: 450 PKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 505
PKI W R + Q L L + DSG Y C N AG + + I
Sbjct: 3611 PKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIH 3670
Query: 506 VTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSI----DGAY 561
P + P+ +V T ++ C VP + +K D +G+
Sbjct: 3671 TVP--TIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSL 3728
Query: 562 TIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRE 597
I+ +DAG Y C + N GS D QGR+
Sbjct: 3729 RIQPVLAQDAGHYLCLASNSAGS-------DRQGRD 3757
Score = 77.4 bits (189), Expect = 4e-14
Identities = 97/400 (24%), Positives = 156/400 (39%), Gaps = 50/400 (12%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDN-----GNLQHLS 271
L+V + P VN + + E SVT+ C + G+P P++ W K G +
Sbjct: 1880 LKVLVPPNIEPGPVNKA--VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVD 1937
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP-EIEMSGGLVNGSSVT 330
G L + ++ D+G Y C N+ G L V PR + G ++ + V
Sbjct: 1938 GRV-LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVR 1996
Query: 331 VSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALV 390
++C T++ +L+D + S F G+ L
Sbjct: 1997 LTCNATGA-----------PSPTLM----WLKDGNPVSPAGTPGLQVF-----PGGRVLT 2036
Query: 391 CQAKLHIDDMEFE-------PKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCL 443
+ D + + RQ L V++ P ++ S + E SV + C
Sbjct: 2037 LASARASDSGRYSCVAVSAVGEDRQDV-VLQVHMPPSILGEELNVSVVANE--SVALECQ 2093
Query: 444 SQGFPAPKILW---SRQL-PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKE 499
S P P + W R L P + ++ A L + + D+G Y CE +NQAG S K
Sbjct: 2094 SHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKH 2153
Query: 500 VELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAE------TGDTV 553
L + V P L + +V+EG +SC C VP I +K + G
Sbjct: 2154 YNLNVWVAPV-FPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQH 2212
Query: 554 LKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
+ ++ + +AQL G Y CE N VG+ + L L+V
Sbjct: 2213 VSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV 2252
Score = 77.4 bits (189), Expect = 4e-14
Identities = 133/589 (22%), Positives = 223/589 (37%), Gaps = 92/589 (15%)
Query: 31 PESRYLAQI-GDSVSLTCSTTGCESPFFSW---RTQIDSP-LNGKVTNEGTTSTLTMNPV 85
P++ ++Q+ G + LTC +G +P +W R ++S ++G V+ G + P
Sbjct: 3129 PKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPA 3188
Query: 86 SFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-----GKPITVKCSVA 140
G +Y C A + K V + P+ I SG G+ + + C
Sbjct: 3189 QAG---TYTCVAENTQAEARKDFVVAVLVAPR---IRSSGVAREHHVLEGQEVRLDCEAD 3242
Query: 141 DVYPFDR--LEIDLLKGDHLMKSQEFLEDADRKSLETKSLE---------VTFTPVIEDI 189
P D L+ G + F D SL K L V P ED
Sbjct: 3243 GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG--SLVLKGLRASDAGAYTCVAHNPAGED- 3299
Query: 190 GKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSE 249
A+LH + PT++Q T++S + G VTM C
Sbjct: 3300 -------ARLHTVNVLVPPTIKQGA-------DGSGTLVS-------RPGELVTMVCPVR 3338
Query: 250 GLPAPEIFWSKK-----LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV 304
G P + W K L L H SG+ TL + +++ D+GI+ C + G +
Sbjct: 3339 GSPPIHVSWLKDGLPLPLSQRTLLHGSGH-TLRISKVQLADAGIFTCVAASPAGVADRNF 3397
Query: 305 ELIVQAFPRDPEIEMSGG--LVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLE 362
L VQ P +E +V GS V + C+ V PL L + GE +L + LE
Sbjct: 3398 TLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGV-PLP-LVSWMKDGEPLLS--QSLE 3453
Query: 363 DTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDT 422
SL+ +++ T + +A+ H EP ++ + + T
Sbjct: 3454 QG--PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP--------HIEDSGQPT 3503
Query: 423 TVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDS 482
+ ++P G+ + + C +QG P P I W + +G+ EN + ++ D+
Sbjct: 3504 ELSLTP------GAPMELLCDAQGTPQPNITWHK---DGQALTRLENNSRATRVLRVRDA 3554
Query: 483 GVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---T 539
G+Y C + AG K + +Q P + +++ C+ P T
Sbjct: 3555 GLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT 3614
Query: 540 W----IILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGS 584
W I+L++ A T ++ D+G Y C ++N GS
Sbjct: 3615 WHRDGIVLQEDAH---TQFPERGRFLQLQALSTADSGDYSCTARNAAGS 3660
Score = 75.1 bits (183), Expect = 2e-13
Identities = 95/418 (22%), Positives = 160/418 (38%), Gaps = 59/418 (14%)
Query: 212 QAVKELQVYISPKNTVISVNPSTKL--QEGGSVTMTCSSEGLPAPEIFWSKK----LDNG 265
Q ++ Q+ + T+ N + ++ E V + C + G+P P I W K +
Sbjct: 1488 QQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST 1547
Query: 266 NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGG--- 322
+ + G L L + D+G+Y C+ N +G K L V P IE +GG
Sbjct: 1548 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV---PPTIEGAGGRPY 1604
Query: 323 ---LVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFI 379
V G V + C V +P L +G + E+ E +TD L +S
Sbjct: 1605 VVKAVAGRPVALEC-VARGHPSPTLSWHH-EGLPVAESNESRLETDGSVLRLES------ 1656
Query: 380 PTIEDTGK-ALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSV 438
P +G + V + +++ + + Q L + TT++ G +
Sbjct: 1657 PGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV---------GQPL 1707
Query: 439 NMTCLSQGFPAPKILWSRQLPNGE-------LQPLSENATLTLISTKMEDSGVYLCEGIN 491
+ C + G P P I W L NG +Q S+ TL + +++ SG++ C+ N
Sbjct: 1708 ELPCQASGSPVPTIQW---LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATN 1764
Query: 492 QAGRSRKEVELII--QVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKK--- 546
+AG + EVE+ + + P +++ E + + V W K
Sbjct: 1765 EAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLV 1824
Query: 547 -----------AETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
TG V S+ I K L+D G+Y C + N G R + L V
Sbjct: 1825 EGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKV 1882
Score = 74.7 bits (182), Expect = 2e-13
Identities = 124/578 (21%), Positives = 212/578 (36%), Gaps = 88/578 (15%)
Query: 40 GDSVSLTCSTTGCESPFFSW-RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
G+ V++ C G SW + + PL+ + G+ TL ++ V + + C A
Sbjct: 3328 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 3387
Query: 99 CESRKLEKG--IQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGD 156
+ ++ +QV++ + E + G + + C V P + +K
Sbjct: 3388 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGV-PLPL--VSWMKDG 3444
Query: 157 HLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKE 216
+ SQ LE LE + T + + R + M+ P + + +
Sbjct: 3445 EPLLSQS-LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEP-PHIEDSGQP 3502
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATL 276
++ ++P G + + C ++G P P I W K D L L N+
Sbjct: 3503 TELSLTP---------------GAPMELLCDAQGTPQPNITWHK--DGQALTRLENNSRA 3545
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQA-----FPRDPEIEMSGGLVNGSSVTV 331
T + +R+ D+G+Y C + G K + VQA PR P + GL G V +
Sbjct: 3546 TRV-LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVV--GLAPGQLV-L 3601
Query: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC 391
C V + P ++ + I ED + E G+ L
Sbjct: 3602 ECSVEAE-PAPKITWHR-------DGIVLQEDAHTQFPER--------------GRFLQL 3639
Query: 392 QAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMT----CLSQGF 447
QA D ++ R + + V TV S SVN T C + G
Sbjct: 3640 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 3699
Query: 448 PAPKILWSR-QLPNGELQPLSE---NATLTLISTKMEDSGVYLCEGINQAGRSRKEVEL- 502
PAP + W + ++P P E +L + +D+G YLC N AG R+ +L
Sbjct: 3700 PAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR 3759
Query: 503 -----IIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSI 557
I +P ++ LTA ++ C P+ ++ K + D L+
Sbjct: 3760 VLEPPAIAPSPSNLTLTAH--------TPALLPCEASGSPKPLVVWWKDGQKLDFRLQ-- 3809
Query: 558 DGAYTIRKAQL--------KDAGVYECESKNKVGSQLR 587
GAY + + +D+ +EC N+VG R
Sbjct: 3810 QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHR 3847
Score = 71.6 bits (174), Expect = 2e-12
Identities = 134/596 (22%), Positives = 220/596 (36%), Gaps = 97/596 (16%)
Query: 36 LAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNG----KVTNEGTTSTLTMNPVSFGNEH 91
L G V L C T+G +P W L G +V +G +T + V G+E
Sbjct: 1419 LGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV--GDEG 1476
Query: 92 SYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEID 151
Y C A + + + Q+ +++ P + G E G+ ++ D L +
Sbjct: 1477 RYQCVAFSPAGQQARDFQLRVHAPPT-----IWGSNETGEVAVME---------DHL-VQ 1521
Query: 152 LLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDI--GKVLVCRAKLHIDEMDSVPT 209
LL + + D L T S +V +T + G+ A ++ + +
Sbjct: 1522 LLCEARGVPTPNITWFKDGALLPT-STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 1580
Query: 210 VRQAVKELQVYISPKNTVISVNPST-KLQEGGSVTMTCSSEGLPAPEIFWSKK----LDN 264
+ L VY+ P P K G V + C + G P+P + W + ++
Sbjct: 1581 AAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAES 1640
Query: 265 GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLV 324
+ + + L L + SG+Y C + G+ + + VQ P++ ++ GL
Sbjct: 1641 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV---PPQLLVAEGL- 1696
Query: 325 NGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIED 384
VT P LE+ + + I++L++ P E
Sbjct: 1697 --GQVTTIVGQP-------LELPCQASGSPVPTIQWLQNGR--------------PAEEL 1733
Query: 385 TGKALVCQAK-LHIDDMEFEPKQRQSTQ-TLYVNVAPRDTTVLV----SPSSI------- 431
G + Q LHID +E + + Q T A + V V +P +
Sbjct: 1734 AGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQY 1793
Query: 432 ---LEEGSSVNMTC---------------LSQGFPAPKILWSRQLPNGELQPLSENATLT 473
E SS C L +G+ +P LW P G S L
Sbjct: 1794 HWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE--PTGIPVAYSLPPPLQ 1851
Query: 474 LISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFP-SESVKEGDTVIISCT 532
+ + D G+Y C N AG S++EV L + V P + P +++V E +V + C
Sbjct: 1852 IEKVDLRDEGIYTCAATNLAGESKREVALKVLVPP---NIEPGPVNKAVLENASVTLECL 1908
Query: 533 CGNVPE---TWIILKKKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGS 584
VP +W + + V S+DG I +AQL DAG Y C + N GS
Sbjct: 1909 ASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS 1964
Score = 70.9 bits (172), Expect = 4e-12
Identities = 125/592 (21%), Positives = 229/592 (38%), Gaps = 69/592 (11%)
Query: 40 GDSVSLTCSTTGCESPFFSWRTQIDS-PLNGK----VTNEGTTSTLTMNPVSFGNEHSYL 94
G++ SL C G P +WR S PL+G+ V EG+ +++P G+ Y
Sbjct: 1221 GENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGD---YE 1277
Query: 95 CTATCESRKLEKGIQVEIYSFPKDPE----IHLSGPLEAGKPITVKCSVADVYPFDRLEI 150
C AT E + ++ +Y P E ++SG AG+ +T++C D F EI
Sbjct: 1278 CQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGM--AGQSLTLEC---DANGFPVPEI 1332
Query: 151 DLLKGDHLMK----------SQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLH 200
LK L+ + + + L+ + + F + E + CRA+
Sbjct: 1333 VWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLD-EGQSLHFPRIQEGDSGLYSCRAENQ 1391
Query: 201 IDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQ--EGGSVTMTCSSEGLPAPEIFW 258
A ++ + + +V+ + ++ G V + C + G+P P++ W
Sbjct: 1392 AGT---------AQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW 1442
Query: 259 SKK----LDNG-NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR 313
+K L G +LQ L + + D G Y C + G+ ++ +L V A P
Sbjct: 1443 TKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 1502
Query: 314 DPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETI-LENIEFLEDTDMKSLENK 372
+ GS+ T V D L L + + NI + +D + K
Sbjct: 1503 ----------IWGSNETGEVAVME----DHLVQLLCEARGVPTPNITWFKDGALLPTSTK 1548
Query: 373 SLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSIL 432
+ ++ G+A A ++ + L V V P P +
Sbjct: 1549 VVYTRGGRQLQ-LGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVK 1607
Query: 433 E-EGSSVNMTCLSQGFPAPKILWSRQ-LP---NGELQPLSENATLTLISTKMEDSGVYLC 487
G V + C+++G P+P + W + LP + E + ++ + L L S SG+Y C
Sbjct: 1608 AVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSC 1667
Query: 488 EGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILK 544
+ AG + + + +QV P+ + + G + + C P W+
Sbjct: 1668 VASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG 1727
Query: 545 KKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQG 595
+ AE V + G I +L +G++ C++ N+ G+ + + V G
Sbjct: 1728 RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 1779
Score = 69.3 bits (168), Expect = 1e-11
Identities = 124/580 (21%), Positives = 221/580 (38%), Gaps = 63/580 (10%)
Query: 41 DSVSLTCSTTGCESPFFSWRTQIDSPLNGK--VTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
+SV+L C + P SW PL + V + L ++ + Y C A
Sbjct: 2086 ESVALECQSHAMPPPVLSWWKD-GRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEAL 2144
Query: 99 CESRKLEKGIQVEIYSFPKDP--EIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGD 156
++ EK + ++ P P E H E G P ++ C V PF ++
Sbjct: 2145 NQAGHSEKHYNLNVWVAPVFPLRESHTLTVRE-GHPTSLSCECRGV-PFPKIS------- 2195
Query: 157 HLMKSQEFLEDADRKSLETKSLE-VTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVK 215
+ +D E L+ V+ + +G+ + + + E +V
Sbjct: 2196 -------WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDL 2248
Query: 216 ELQVYISPKNTVISVNPS-TKLQEGGSVTMTCSSEGLPAPEIFWSKKLD----NGNLQHL 270
+L+V++ P+ P+ + + G T+ C++ G P P + W + LQ
Sbjct: 2249 QLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQ 2308
Query: 271 SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR-----DPEIEMSGGLVN 325
+ +L + + +G Y C NL G+ ++ EL V P DP ++ L
Sbjct: 2309 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAAL-- 2366
Query: 326 GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDT 385
S +T+ C+ + P I +GE E + EDT + + L+MT T E
Sbjct: 2367 HSPLTLLCEAMGIPPP---AIRWFRGE---EPVSPGEDTYLLA-GGWMLKMT--QTQEQD 2417
Query: 386 GKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQ 445
C A E ++ S + L V P + + +G + ++ C
Sbjct: 2418 SGLYSCLASNEAG----EARRNFSVEVL---VPPSIENEDLEEVIKVLDGQTAHLMCNVT 2470
Query: 446 GFPAPKILW---SRQLPNGELQPLS-ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVE 501
G P PK+ W R L G+ +S + L ++ + +G Y C N G K +
Sbjct: 2471 GHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQ 2530
Query: 502 LIIQVTPKDI---KLTAFPSESVKEGDTVIISCTCGNVPETWIILKK-----KAETGDTV 553
L + + P + + +A +V + + + C P I K +A +
Sbjct: 2531 LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL 2590
Query: 554 LKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
L G I AQ +DAG Y C N++G +++ ++V
Sbjct: 2591 LPGTHG-LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV 2629
Score = 66.6 bits (161), Expect = 7e-11
Identities = 87/373 (23%), Positives = 145/373 (38%), Gaps = 48/373 (12%)
Query: 228 ISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNG-------NLQHLSGNATLTLIA 280
++VN S+ +V++ C + G P P I W L NG LQ L L +
Sbjct: 2855 VTVNASS------TVSLQCPALGNPVPTISW---LQNGLPFSPSPRLQVLEDGQVLQVST 2905
Query: 281 MRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP--EIEMSGGLVNGSSVTVSCKVPSV 338
+ D+ Y+C N G K L VQ PR ++E ++N SSV++ C V
Sbjct: 2906 AEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN-SSVSLPC---DV 2961
Query: 339 YPLDRLEIELLKGETIL---ENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKL 395
+ E+ K L E + L T L L + + T E A Q +
Sbjct: 2962 HAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLV 3021
Query: 396 HIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWS 455
+ + P RQ+ + P+D ++ G ++C + P P + W
Sbjct: 3022 QLSVL-VPPAFRQAPR------GPQDAV-------LVRVGDKAVLSCETDALPEPTVTWY 3067
Query: 456 RQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDI 511
+ + Q L L + ++ D G+Y C+ N AG + + L +QV P
Sbjct: 3068 KDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQV-PPTF 3126
Query: 512 KLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDT-VLKSIDGAYTIRKAQ 567
+ + S G ++++C VP TW+ + E+ + S G + + Q
Sbjct: 3127 ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQ 3186
Query: 568 LKDAGVYECESKN 580
AG Y C ++N
Sbjct: 3187 PAQAGTYTCVAEN 3199
Score = 59.7 bits (143), Expect = 8e-09
Identities = 51/187 (27%), Positives = 82/187 (43%), Gaps = 21/187 (11%)
Query: 415 VNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTL 474
V PR VLV G ++++ C+++G P P++ WS+ LQ ++
Sbjct: 1122 VQPGPRVLKVLV--------GEALDLNCVAEGNPEPQLSWSKD--GVVLQGRGPQGSVHF 1171
Query: 475 ISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK-DIKLTAFPSESVKEGDTVIISCTC 533
+ + D+G Y CE N AG EVEL + P T+ E V G+ + C
Sbjct: 1172 AAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVA-GENASLPCPA 1230
Query: 534 GNVPETWIILKK-------KAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQL 586
P+ + +K + G VL+ +G+ + D+G YEC++ N+VGS
Sbjct: 1231 RGTPKPQVTWRKGPSSEPLHGQPGVAVLE--EGSLFLASVSPADSGDYECQATNEVGSTS 1288
Query: 587 RSLTLDV 593
R L V
Sbjct: 1289 RRAKLVV 1295
Score = 58.9 bits (141), Expect = 1e-08
Identities = 91/422 (21%), Positives = 163/422 (38%), Gaps = 46/422 (10%)
Query: 210 VRQAVKELQVYISPKNTVI-----SVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK--- 261
V + K Q+ + T++ S + + +++ C + P+P I W K
Sbjct: 2522 VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 2581
Query: 262 -LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR----DPE 316
+ N+Q L G L ++ + ED+G Y C N +G+ K + V P DP
Sbjct: 2582 FEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPL 2641
Query: 317 IEMSGGLVN---GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKS 373
E+ V S++T+ C+ +V P + + T ++ L + + ++
Sbjct: 2642 GEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQ--- 2698
Query: 374 LEMTFIPT-IEDTGKAL-VCQAKLHIDDMEFEPK-------QRQSTQTLYVNVAPRDTTV 424
PT + D+G+ L V DD +F Q+ + + R+
Sbjct: 2699 ------PTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEA 2752
Query: 425 L--VSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTK 478
V+ + E + + C + P P + W R+ E+ L L + +
Sbjct: 2753 RGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVR 2812
Query: 479 MEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTC---GN 535
E++G Y C+ N+ G EL++ P + T E V + +S C GN
Sbjct: 2813 AENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN 2872
Query: 536 -VPE-TWIILKKKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLD 592
VP +W+ + DG + A++ DA Y C ++N+ GS + TL
Sbjct: 2873 PVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLR 2932
Query: 593 VQ 594
VQ
Sbjct: 2933 VQ 2934
Score = 53.5 bits (127), Expect = 6e-07
Identities = 82/331 (24%), Positives = 131/331 (39%), Gaps = 60/331 (18%)
Query: 29 TTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFG 88
T P R L ++GD + L C+ G +P W T D P+ V+ + STL VS
Sbjct: 4133 TLPGDRSL-RLGDRLWLRCAARGSPTPRIGW-TVNDRPVTEGVSEQDGGSTLQRAAVSRE 4190
Query: 89 NEHSYLCTATCESR------------KLEKGIQVEIYSFPKDPEIHLSGPLEA-----GK 131
+ +Y+C A E+R K +Q E +S+ +P + G ++ G
Sbjct: 4191 DSGTYVCWA--ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP---VGGSIQLDCVVRGD 4245
Query: 132 PITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGK 191
P+ + D P L+G HL R L+ SL + T +D G+
Sbjct: 4246 PVPDIHWIKDGLP--------LRGSHL-----------RHQLQNGSLTIHRTER-DDAGR 4285
Query: 192 VLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTK-LQEGGSVTMTCSSEG 250
C A+ +EM K++ + + V V P ++ G V + C + G
Sbjct: 4286 YQ-CLAE---NEMG-------VAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATG 4334
Query: 251 LPAPEIFW---SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELI 307
P P I W + L + +L L + D+G Y C NL+G L+
Sbjct: 4335 EPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLV 4394
Query: 308 VQAFPRDPEIEMSGGLVNGSSVTVSCKVPSV 338
V+ P+ M+ G++NG V+ SV
Sbjct: 4395 VRGEPQGSWGSMT-GVINGRKFGVATLNTSV 4424
Score = 51.6 bits (122), Expect = 2e-06
Identities = 49/209 (23%), Positives = 81/209 (38%), Gaps = 27/209 (12%)
Query: 434 EGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLS---------ENATLTLISTKMEDSGV 484
E +SV + CL+ G P P + W + QP+S + L + ++ D+G
Sbjct: 1899 ENASVTLECLASGVPPPDVSWFK-----GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGS 1953
Query: 485 YLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILK 544
Y C N AG + L + V P+ + P V V ++C P ++
Sbjct: 1954 YRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG-PVLVNTPVRLTCNATGAPSPTLMWL 2012
Query: 545 KK----AETGDTVLKSIDG--AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ---- 594
K + G L+ G T+ A+ D+G Y C + + VG + + L V
Sbjct: 2013 KDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 2072
Query: 595 --GRENNKDYFSPELLVLYFASSLIIPAI 621
G E N + E + L S + P +
Sbjct: 2073 ILGEELNVSVVANESVALECQSHAMPPPV 2101
Score = 51.6 bits (122), Expect = 2e-06
Identities = 79/320 (24%), Positives = 123/320 (38%), Gaps = 69/320 (21%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWS---KKLDNGNLQHLSGN 273
L + + P T + + S +L G + + C++ G P P I W+ + + G + G
Sbjct: 4123 LTILVLPVFTTLPGDRSLRL--GDRLWLRCAARGSPTPRIGWTVNDRPVTEG-VSEQDGG 4179
Query: 274 ATLTLIAMRMEDSGIYVCEGVNLIGKNR-------KEVELIVQAFPRDPEIEMSGGLVNG 326
+TL A+ EDSG YVC N +G+ + KE ++Q +E GG +
Sbjct: 4180 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP-VLQGEAFSYLVEPVGGSIQL 4238
Query: 327 SSVTVSCKVPSVYPL-DRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDT 385
V VP ++ + D L L+G + L+N SL T T D
Sbjct: 4239 DCVVRGDPVPDIHWIKDGLP---LRGSHLRHQ-----------LQNGSL--TIHRTERDD 4282
Query: 386 GKALVCQAKLHIDDMEFEPKQ----RQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMT 441
C A+ ++M K QS V P+D TV G V +
Sbjct: 4283 AGRYQCLAE---NEMGVAKKVVILVLQSAPVFQVE--PQDMTV--------RSGDDVALR 4329
Query: 442 CLSQGFPAPKILWS------------RQLPNGELQPLSENATLTLISTKMEDSGVYLCEG 489
C + G P P I W R LP+G +L L + + D+G Y C
Sbjct: 4330 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDG---------SLWLENVETGDAGTYDCVA 4380
Query: 490 INQAGRSRKEVELIIQVTPK 509
N G + L+++ P+
Sbjct: 4381 HNLLGSATARAFLVVRGEPQ 4400
Score = 44.7 bits (104), Expect = 3e-04
Identities = 35/135 (25%), Positives = 61/135 (45%), Gaps = 12/135 (8%)
Query: 467 SENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDT 526
S N++ ++ + G Y C +++AG R + ++++ P +L P+ +V G+T
Sbjct: 476 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP--QLVPAPNVTVSPGET 533
Query: 527 VIISC-TCGNVP------ETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESK 579
++SC G P W +L A TG V + D + I D G Y+C +
Sbjct: 534 AVLSCRVLGEAPYNLTWVRDWRVL--PASTG-RVAQLADLSLEISGIIPTDGGRYQCVAS 590
Query: 580 NKVGSQLRSLTLDVQ 594
N G S+ L V+
Sbjct: 591 NANGVTRASVWLLVR 605
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 106 bits (264), Expect = 8e-23
Identities = 148/613 (24%), Positives = 254/613 (41%), Gaps = 81/613 (13%)
Query: 28 ETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSF 87
E + + + + +SL C SP +W +P + T + ++
Sbjct: 1262 EDSADEEVTVTVNNPISLICEALAFPSPNITWMKD-GAPFEASRNIQLLPGTHGLQILNA 1320
Query: 88 GNEHS--YLCTATCESRKLEKGIQVEIY---SFPKDPEIHLSGPLEA----GKPITVKC- 137
E + Y C T E + K VE+ S KD + G E +T++C
Sbjct: 1321 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECE 1380
Query: 138 SVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRA 197
S A P R D G + S + + L+ + +V+ D G+ L
Sbjct: 1381 SWAVPPPTIRWYKD---GQPVTPSSRLQVLGEGRLLQIQPTQVS------DSGRYLCVAT 1431
Query: 198 KLH-IDEMD-----SVPTVRQAVKEL----QVYISPKNTVISVNPSTKLQEGGSVTMTCS 247
+ D+ D VP + Q V + ++ + V ++ E + C
Sbjct: 1432 NVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1491
Query: 248 SEGLPAPEIFWSKK---LDNGN-LQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKE 303
+ +P P++ W ++ L G+ + L G L + +R E++G Y C+ N +G++
Sbjct: 1492 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1551
Query: 304 VELIVQAFP---RDPEIEMSGGLVNGSSVTVSCKVPSV-YPLDRLEIELLKGETILENIE 359
EL+V P D E + VN SS TVS + P++ P+ + + +
Sbjct: 1552 YELLVLTPPVILGDTEELVEEVTVNASS-TVSLQCPALGNPVPTIS-------WLQNGLP 1603
Query: 360 FLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAP 419
F ++ LE+ + + D + +C A E + + TL V V P
Sbjct: 1604 FSPSPRLQVLEDGQVLQVSTAEVADAA-SYMCVA-------ENQAGSAEKLFTLRVQVPP 1655
Query: 420 RDTTV-LVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGE-LQPLSENATLTL 474
R + L ++IL SSV++ C P P++ W S+ L GE + L TL L
Sbjct: 1656 RIAGLDLEQVTAILN--SSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQL 1713
Query: 475 ISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSES--VKEGDTVIISCT 532
++ DSG+Y CE +N AGR +K V+L + V P + P ++ V+ GD ++SC
Sbjct: 1714 GRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCE 1773
Query: 533 CGNVPE---TW------IILKKKAET--GDTVLKSIDGAYTIRKAQLKDAGVYECESKNK 581
+PE TW ++L ++ + G L+ I++AQ+ D G+Y C+ N
Sbjct: 1774 TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLE-------IQEAQVSDKGLYSCKVSNV 1826
Query: 582 VGSQLRSLTLDVQ 594
G +R+ TL VQ
Sbjct: 1827 AGEAVRTFTLTVQ 1839
Score = 94.0 bits (232), Expect = 4e-19
Identities = 126/573 (21%), Positives = 218/573 (38%), Gaps = 69/573 (12%)
Query: 43 VSLTCSTTGCESPFFSWR---TQIDSPLNG-KVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
V LTC +TG +P SW Q+ + +G +V+ G P+ G Y C+A
Sbjct: 2592 VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR---YTCSAR 2648
Query: 99 CESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHL 158
+ K + + + + P + A + + + C + + R I K
Sbjct: 2649 NSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGI---PRPTITWQK---- 2701
Query: 159 MKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQ 218
+ + L L + ED G L C AK + A+ + +
Sbjct: 2702 -EGLNVATGVSTQVLPGGQLRIAHASP-EDAGNYL-CIAK---------NSAGSAMGKTR 2749
Query: 219 VYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLT- 277
+ + + + P EG + C + G P P I W K D + G T+
Sbjct: 2750 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK--DGQPVSGAEGKFTIQP 2807
Query: 278 ---LIAMRME--DSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVS 332
L+ +E D+G Y C N +G+ R+ V L + P + L G + +
Sbjct: 2808 SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLR 2867
Query: 333 CKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQ 392
C P R+ + + E + E +L+ ++ ED+G VC
Sbjct: 2868 CAARGS-PTPRIGWTV-NDRPVTEGVS--EQDGGSTLQRAAVSR------EDSG-TYVCW 2916
Query: 393 AKLHIDDMEFEPKQRQSTQTLYVNVAP----RDTTVLVSPSSILEEGSSVNMTCLSQGFP 448
A+ + + Q+ ++V AP + LV P G S+ + C+ +G P
Sbjct: 2917 AENRVG-------RTQAVSFVHVKEAPVLQGEAFSYLVEPV-----GGSIQLDCVVRGDP 2964
Query: 449 APKILWSRQ---LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 505
P I W + L L+ +N +LT+ T+ +D+G Y C N+ G ++K V L++Q
Sbjct: 2965 VPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQ 3024
Query: 506 VTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDGAYT 562
P + +V+ GD V + C P W+ + + DG+
Sbjct: 3025 SAP--VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLW 3082
Query: 563 IRKAQLKDAGVYECESKNKVGSQLRSLTLDVQG 595
+ + DAG Y+C + N +GS L V+G
Sbjct: 3083 LENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3115
Score = 93.2 bits (230), Expect = 7e-19
Identities = 129/606 (21%), Positives = 240/606 (39%), Gaps = 60/606 (9%)
Query: 31 PESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNE-GTTSTLTMNPVSFGN 89
P+ L ++GD L+C T P +W + + T L + +
Sbjct: 1756 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 1815
Query: 90 EHSYLCTATCESRKLEKGIQVEIYSFP--KDPEIHLSGPLEAGKPITVKCSVADVYPFDR 147
+ Y C + + + + + + P ++P+ + AG P+ + C V+ V
Sbjct: 1816 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQV-AGSPLVLTCDVSGV---PA 1871
Query: 148 LEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCR---AKLHIDEM 204
+ LK DR +E+ ++ V+ G++ + R A+
Sbjct: 1872 PTVTWLK--------------DRMPVESSAVH----GVVSRGGRLQLSRLQPAQAGTYTC 1913
Query: 205 DSVPTVRQAVKE--LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK- 261
+ T +A K+ + V ++P+ V + EG V + C ++G P P++ W K
Sbjct: 1914 VAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDG 1973
Query: 262 ----LDNG-NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPE 316
D G +L+ +L L +R D+G Y C N G++ + + V P +
Sbjct: 1974 SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQ 2033
Query: 317 -IEMSGGLVN--GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKS 373
+ SG LV+ G VT+ C V P+ + LK L L + +
Sbjct: 2034 GADGSGTLVSRPGELVTMVCPVRGSPPI---HVSWLKDGLPLP----LSQRTLLHGSGHT 2086
Query: 374 LEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE 433
L ++ + + V + + D F TL V V P V ++
Sbjct: 2087 LRISKVQLADAGIFTCVAASPAGVADRNF---------TLQVQVPPVLEPVEFQNDVVVV 2137
Query: 434 EGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQA 493
GS V + C ++G P P + W + Q L + +L L + DSG Y C +++A
Sbjct: 2138 RGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEA 2197
Query: 494 GRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGNVPETWIILKKKAETGDT 552
G +R+ +L + + P I+ + P+E S+ G + + C P+ I K G
Sbjct: 2198 GEARRHFQLTV-MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK---DGQA 2253
Query: 553 VLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYF 612
+ + + + R +++DAG+Y C +++ G+ +S + VQ N P +V
Sbjct: 2254 LTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLA 2313
Query: 613 ASSLII 618
L++
Sbjct: 2314 PGQLVL 2319
Score = 92.8 bits (229), Expect = 9e-19
Identities = 123/587 (20%), Positives = 216/587 (36%), Gaps = 76/587 (12%)
Query: 39 IGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTS--------TLTMNPVSFGNE 90
+ V LTC+ TG SP W V+ GT LT+ +
Sbjct: 709 VNTPVRLTCNATGAPSPTLMWLKD-----GNPVSPAGTPGLQVFPGGRVLTLASARASDS 763
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEI 150
Y C A + + + ++++ P L+ + A + + ++C
Sbjct: 764 GRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQ------------ 811
Query: 151 DLLKGDHLMKSQEFLEDADRKSLETK-SLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPT 209
H M D + LE + + ++ + + + V A + E +
Sbjct: 812 -----SHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAG 866
Query: 210 VRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKL-----DN 264
+ L V+++P + + T ++EG ++C G+P P+I W K +
Sbjct: 867 HSEKHYNLNVWVAPVFPLRESHTLT-VREGHPTRLSCECRGVPFPKISWRKDGQPLPGEG 925
Query: 265 GNLQHLSGNATLTLIAM-RMEDSGIYVCEGVNLIGKNRKEVELIVQ-----AFPRDPEIE 318
LQH+S L + ++ G Y CE N++G + ++++L V A PR+P +
Sbjct: 926 AGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQ 985
Query: 319 MSGGLVNGSSVTVSC----KVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSL 374
+S +V T+ C K P +R G+ + + +SL +
Sbjct: 986 VS--VVQDGVATLECNATGKPPPTVTWER------DGQPVGAELGLQLQNQGQSLHVERA 1037
Query: 375 EMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEE 434
+ + L +A+ + P + N+ T L SP ++L
Sbjct: 1038 QAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI----TAALHSPLTLL-- 1091
Query: 435 GSSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGI 490
C + G P P I W R P + L+ L + T+ +DSG+Y C
Sbjct: 1092 -------CEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS 1144
Query: 491 NQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKA 547
N+AG +R+ + + V P V +G T + C P+ TW +
Sbjct: 1145 NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 1204
Query: 548 ETGDTVLKSIDGA-YTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
GD S DG + +A L AG Y C + N VG + + L V
Sbjct: 1205 ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV 1251
Score = 86.3 bits (212), Expect = 8e-17
Identities = 142/599 (23%), Positives = 223/599 (37%), Gaps = 89/599 (14%)
Query: 20 AASQAFKIE--TTPESR-----YLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGK-- 70
+ S AF++E T P R + + L C G +P SWR PL+ +
Sbjct: 2378 STSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD-RVPLDPRSP 2436
Query: 71 ---VTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPL 127
+ EG+ L + PV + YLC A+ + +G + + P + L
Sbjct: 2437 RFEILPEGS---LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTL 2493
Query: 128 EAGKPITVKCSVAD------VYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVT 181
A P + C + V+ D ++D L+ + L + +L +T
Sbjct: 2494 TAHTPALLPCEASGSPKPLVVWWKDGQKLDFR-----------LQQGAYRLLPSNALLLT 2542
Query: 182 FTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGS 241
P +D + E V +A + QV + T+ +
Sbjct: 2543 -APGPQDSAQF----------ECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAP 2591
Query: 242 VTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLI 297
V +TC S G+PAP + WSK G+ +S + L + +G Y C N
Sbjct: 2592 VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSA 2651
Query: 298 GKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILEN 357
G K V L VQA P + V V + C+ + R I K E
Sbjct: 2652 GVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGI---PRPTITWQK-----EG 2703
Query: 358 IEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV 417
+ + L L + + ED G L C AK L V V
Sbjct: 2704 LNVATGVSTQVLPGGQLRIAH-ASPEDAGNYL-CIAK-------NSAGSAMGKTRLVVQV 2754
Query: 418 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR--QLPNG-----ELQPLSENA 470
P L P EGS + C ++G P P I W + Q +G +QP E
Sbjct: 2755 PPVIENGL--PDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-- 2810
Query: 471 TLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVII 529
L + + + +D+G Y C N GR+R+ V L I V P T P + S++ GD + +
Sbjct: 2811 -LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP---VFTTLPGDRSLRLGDRLWL 2866
Query: 530 SCTCGNVPET---WIILKKKAETGDTVLKSIDGAYTIRKAQL--KDAGVYECESKNKVG 583
C P W + + G + DG T+++A + +D+G Y C ++N+VG
Sbjct: 2867 RCAARGSPTPRIGWTVNDRPVTEG---VSEQDGGSTLQRAAVSREDSGTYVCWAENRVG 2922
Score = 77.8 bits (190), Expect = 3e-14
Identities = 99/396 (25%), Positives = 145/396 (36%), Gaps = 52/396 (13%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATL 276
LQV + P + + G V + C + G+P P + W K + Q L +L
Sbjct: 2117 LQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSL 2176
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSG-----GLVNGSSVTV 331
L A+ DSG Y C V+ G+ R+ +L V P IE SG L G+ + +
Sbjct: 2177 QLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM---EPPHIEDSGQPTELSLTPGAPMEL 2233
Query: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTD-MKSLENKSLEMTFIPTIEDTGKALV 390
C T NI + +D + LEN S T + + D G
Sbjct: 2234 LCDAQG---------------TPQPNITWHKDGQALTRLENNS-RATRVLRVRDAG-LYT 2276
Query: 391 CQAKLHIDDMEFEPKQR-QSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPA 449
C A+ +E + R Q+ + PR L +LE C + PA
Sbjct: 2277 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLE--------CSVEAEPA 2328
Query: 450 PKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 505
PKI W R + Q L L + DSG Y C N AG + + I
Sbjct: 2329 PKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIH 2388
Query: 506 VTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSID----GAY 561
P + P+ +V T ++ C VP + +K D + G+
Sbjct: 2389 TVPTI--RSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSL 2446
Query: 562 TIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRE 597
I+ +DAG Y C + N GS D QGR+
Sbjct: 2447 RIQPVLAQDAGHYLCLASNSAGS-------DRQGRD 2475
Score = 77.4 bits (189), Expect = 4e-14
Identities = 133/589 (22%), Positives = 223/589 (37%), Gaps = 92/589 (15%)
Query: 31 PESRYLAQI-GDSVSLTCSTTGCESPFFSW---RTQIDSP-LNGKVTNEGTTSTLTMNPV 85
P++ ++Q+ G + LTC +G +P +W R ++S ++G V+ G + P
Sbjct: 1847 PKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPA 1906
Query: 86 SFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-----GKPITVKCSVA 140
G +Y C A + K V + P+ I SG G+ + + C
Sbjct: 1907 QAG---TYTCVAENTQAEARKDFVVAVLVAPR---IRSSGVAREHHVLEGQEVRLDCEAD 1960
Query: 141 DVYPFDR--LEIDLLKGDHLMKSQEFLEDADRKSLETKSLE---------VTFTPVIEDI 189
P D L+ G + F D SL K L V P ED
Sbjct: 1961 GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG--SLVLKGLRASDAGAYTCVAHNPAGED- 2017
Query: 190 GKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSE 249
A+LH + PT++Q T++S + G VTM C
Sbjct: 2018 -------ARLHTVNVLVPPTIKQGA-------DGSGTLVS-------RPGELVTMVCPVR 2056
Query: 250 GLPAPEIFWSKK-----LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV 304
G P + W K L L H SG+ TL + +++ D+GI+ C + G +
Sbjct: 2057 GSPPIHVSWLKDGLPLPLSQRTLLHGSGH-TLRISKVQLADAGIFTCVAASPAGVADRNF 2115
Query: 305 ELIVQAFPRDPEIEMSGG--LVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLE 362
L VQ P +E +V GS V + C+ V PL L + GE +L + LE
Sbjct: 2116 TLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGV-PLP-LVSWMKDGEPLLS--QSLE 2171
Query: 363 DTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDT 422
SL+ +++ T + +A+ H EP ++ + + T
Sbjct: 2172 QG--PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP--------HIEDSGQPT 2221
Query: 423 TVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDS 482
+ ++P G+ + + C +QG P P I W + +G+ EN + ++ D+
Sbjct: 2222 ELSLTP------GAPMELLCDAQGTPQPNITWHK---DGQALTRLENNSRATRVLRVRDA 2272
Query: 483 GVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---T 539
G+Y C + AG K + +Q P + +++ C+ P T
Sbjct: 2273 GLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT 2332
Query: 540 W----IILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGS 584
W I+L++ A T ++ D+G Y C ++N GS
Sbjct: 2333 WHRDGIVLQEDAH---TQFPERGRFLQLQALSTADSGDYSCTARNAAGS 2378
Score = 77.0 bits (188), Expect = 5e-14
Identities = 97/400 (24%), Positives = 156/400 (39%), Gaps = 50/400 (12%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDN-----GNLQHLS 271
L+V + P VN + + E SVT+ C + G+P P++ W K G +
Sbjct: 598 LKVLVPPNIEPGPVNKA--VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVD 655
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP-EIEMSGGLVNGSSVT 330
G L + ++ D+G Y C N+ G L V PR + G ++ + V
Sbjct: 656 GRV-LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVR 714
Query: 331 VSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALV 390
++C T++ +L+D + S F G+ L
Sbjct: 715 LTCNATGA-----------PSPTLM----WLKDGNPVSPAGTPGLQVF-----PGGRVLT 754
Query: 391 CQAKLHIDDMEFE-------PKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCL 443
+ D + + RQ L V++ P ++ S + E SV + C
Sbjct: 755 LASARASDSGRYSCVAVSAVGEDRQDV-VLQVHMPPSILGEELNVSVVANE--SVALECQ 811
Query: 444 SQGFPAPKILW---SRQL-PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKE 499
S P P + W R L P + ++ A L + + D+G Y CE +NQAG S K
Sbjct: 812 SHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKH 871
Query: 500 VELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAE------TGDTV 553
L + V P L + +V+EG +SC C VP I +K + G
Sbjct: 872 YNLNVWVAPV-FPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQH 930
Query: 554 LKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
+ ++ + +AQL G Y CE N VG+ + L L+V
Sbjct: 931 VSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV 970
Score = 75.1 bits (183), Expect = 2e-13
Identities = 95/418 (22%), Positives = 160/418 (38%), Gaps = 59/418 (14%)
Query: 212 QAVKELQVYISPKNTVISVNPSTKL--QEGGSVTMTCSSEGLPAPEIFWSKK----LDNG 265
Q ++ Q+ + T+ N + ++ E V + C + G+P P I W K +
Sbjct: 206 QQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST 265
Query: 266 NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGG--- 322
+ + G L L + D+G+Y C+ N +G K L V P IE +GG
Sbjct: 266 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV---PPTIEGAGGRPY 322
Query: 323 ---LVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFI 379
V G V + C V +P L +G + E+ E +TD L +S
Sbjct: 323 VVKAVAGRPVALEC-VARGHPSPTLSWHH-EGLPVAESNESRLETDGSVLRLES------ 374
Query: 380 PTIEDTGK-ALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSV 438
P +G + V + +++ + + Q L + TT++ G +
Sbjct: 375 PGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV---------GQPL 425
Query: 439 NMTCLSQGFPAPKILWSRQLPNGE-------LQPLSENATLTLISTKMEDSGVYLCEGIN 491
+ C + G P P I W L NG +Q S+ TL + +++ SG++ C+ N
Sbjct: 426 ELPCQASGSPVPTIQW---LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATN 482
Query: 492 QAGRSRKEVELII--QVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKK--- 546
+AG + EVE+ + + P +++ E + + V W K
Sbjct: 483 EAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLV 542
Query: 547 -----------AETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
TG V S+ I K L+D G+Y C + N G R + L V
Sbjct: 543 EGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKV 600
Score = 74.7 bits (182), Expect = 2e-13
Identities = 124/578 (21%), Positives = 212/578 (36%), Gaps = 88/578 (15%)
Query: 40 GDSVSLTCSTTGCESPFFSW-RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
G+ V++ C G SW + + PL+ + G+ TL ++ V + + C A
Sbjct: 2046 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2105
Query: 99 CESRKLEKG--IQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGD 156
+ ++ +QV++ + E + G + + C V P + +K
Sbjct: 2106 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGV-PLPL--VSWMKDG 2162
Query: 157 HLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKE 216
+ SQ LE LE + T + + R + M+ P + + +
Sbjct: 2163 EPLLSQS-LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEP-PHIEDSGQP 2220
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATL 276
++ ++P G + + C ++G P P I W K D L L N+
Sbjct: 2221 TELSLTP---------------GAPMELLCDAQGTPQPNITWHK--DGQALTRLENNSRA 2263
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQA-----FPRDPEIEMSGGLVNGSSVTV 331
T + +R+ D+G+Y C + G K + VQA PR P + GL G V +
Sbjct: 2264 TRV-LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVV--GLAPGQLV-L 2319
Query: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC 391
C V + P ++ + I ED + E G+ L
Sbjct: 2320 ECSVEAE-PAPKITWHR-------DGIVLQEDAHTQFPER--------------GRFLQL 2357
Query: 392 QAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMT----CLSQGF 447
QA D ++ R + + V TV S SVN T C + G
Sbjct: 2358 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 2417
Query: 448 PAPKILWSR-QLPNGELQPLSE---NATLTLISTKMEDSGVYLCEGINQAGRSRKEVEL- 502
PAP + W + ++P P E +L + +D+G YLC N AG R+ +L
Sbjct: 2418 PAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR 2477
Query: 503 -----IIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSI 557
I +P ++ LTA ++ C P+ ++ K + D L+
Sbjct: 2478 VLEPPAIAPSPSNLTLTAH--------TPALLPCEASGSPKPLVVWWKDGQKLDFRLQ-- 2527
Query: 558 DGAYTIRKAQL--------KDAGVYECESKNKVGSQLR 587
GAY + + +D+ +EC N+VG R
Sbjct: 2528 QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHR 2565
Score = 71.6 bits (174), Expect = 2e-12
Identities = 134/596 (22%), Positives = 220/596 (36%), Gaps = 97/596 (16%)
Query: 36 LAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNG----KVTNEGTTSTLTMNPVSFGNEH 91
L G V L C T+G +P W L G +V +G +T + V G+E
Sbjct: 137 LGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV--GDEG 194
Query: 92 SYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEID 151
Y C A + + + Q+ +++ P + G E G+ ++ D L +
Sbjct: 195 RYQCVAFSPAGQQARDFQLRVHAPPT-----IWGSNETGEVAVME---------DHL-VQ 239
Query: 152 LLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDI--GKVLVCRAKLHIDEMDSVPT 209
LL + + D L T S +V +T + G+ A ++ + +
Sbjct: 240 LLCEARGVPTPNITWFKDGALLPT-STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 298
Query: 210 VRQAVKELQVYISPKNTVISVNPST-KLQEGGSVTMTCSSEGLPAPEIFWSKK----LDN 264
+ L VY+ P P K G V + C + G P+P + W + ++
Sbjct: 299 AAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAES 358
Query: 265 GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLV 324
+ + + L L + SG+Y C + G+ + + VQ P++ ++ GL
Sbjct: 359 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV---PPQLLVAEGL- 414
Query: 325 NGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIED 384
VT P LE+ + + I++L++ P E
Sbjct: 415 --GQVTTIVGQP-------LELPCQASGSPVPTIQWLQNGR--------------PAEEL 451
Query: 385 TGKALVCQAK-LHIDDMEFEPKQRQSTQ-TLYVNVAPRDTTVLV----SPSSI------- 431
G + Q LHID +E + + Q T A + V V +P +
Sbjct: 452 AGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQY 511
Query: 432 ---LEEGSSVNMTC---------------LSQGFPAPKILWSRQLPNGELQPLSENATLT 473
E SS C L +G+ +P LW P G S L
Sbjct: 512 HWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE--PTGIPVAYSLPPPLQ 569
Query: 474 LISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFP-SESVKEGDTVIISCT 532
+ + D G+Y C N AG S++EV L + V P + P +++V E +V + C
Sbjct: 570 IEKVDLRDEGIYTCAATNLAGESKREVALKVLVPP---NIEPGPVNKAVLENASVTLECL 626
Query: 533 CGNVPE---TWIILKKKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGS 584
VP +W + + V S+DG I +AQL DAG Y C + N GS
Sbjct: 627 ASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS 682
Score = 68.6 bits (166), Expect = 2e-11
Identities = 124/580 (21%), Positives = 220/580 (37%), Gaps = 63/580 (10%)
Query: 41 DSVSLTCSTTGCESPFFSWRTQIDSPLNGK--VTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
+SV+L C + P SW PL + V + L ++ + Y C A
Sbjct: 804 ESVALECQSHAMPPPVLSWWKD-GRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEAL 862
Query: 99 CESRKLEKGIQVEIYSFPKDP--EIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGD 156
++ EK + ++ P P E H E G P + C V PF ++
Sbjct: 863 NQAGHSEKHYNLNVWVAPVFPLRESHTLTVRE-GHPTRLSCECRGV-PFPKIS------- 913
Query: 157 HLMKSQEFLEDADRKSLETKSLE-VTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVK 215
+ +D E L+ V+ + +G+ + + + E +V
Sbjct: 914 -------WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDL 966
Query: 216 ELQVYISPKNTVISVNPS-TKLQEGGSVTMTCSSEGLPAPEIFWSKKLD----NGNLQHL 270
+L+V++ P+ P+ + + G T+ C++ G P P + W + LQ
Sbjct: 967 QLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQ 1026
Query: 271 SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR-----DPEIEMSGGLVN 325
+ +L + + +G Y C NL G+ ++ EL V P DP ++ L
Sbjct: 1027 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAAL-- 1084
Query: 326 GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDT 385
S +T+ C+ + P I +GE E + EDT + + L+MT T E
Sbjct: 1085 HSPLTLLCEAMGIPPP---AIRWFRGE---EPVSPGEDTYLLA-GGWMLKMT--QTQEQD 1135
Query: 386 GKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQ 445
C A E ++ S + L V P + + +G + ++ C
Sbjct: 1136 SGLYSCLASNEAG----EARRNFSVEVL---VPPSIENEDLEEVIKVLDGQTAHLMCNVT 1188
Query: 446 GFPAPKILW---SRQLPNGELQPLS-ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVE 501
G P PK+ W R L G+ +S + L ++ + +G Y C N G K +
Sbjct: 1189 GHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQ 1248
Query: 502 LIIQVTPKDI---KLTAFPSESVKEGDTVIISCTCGNVPETWIILKK-----KAETGDTV 553
L + + P + + +A +V + + + C P I K +A +
Sbjct: 1249 LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL 1308
Query: 554 LKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
L G I AQ +DAG Y C N++G +++ ++V
Sbjct: 1309 LPGTHG-LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV 1347
Score = 66.6 bits (161), Expect = 7e-11
Identities = 54/196 (27%), Positives = 86/196 (43%), Gaps = 20/196 (10%)
Query: 418 APRDTTVLV-SPSSILEEGSS----------VNMTCLSQGFPAPKILWSRQ----LPNG- 461
A RD +LV +P S+L G++ V + C + G P P++ W++ LP G
Sbjct: 113 AQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGP 172
Query: 462 ELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESV 521
LQ + L + + + D G Y C + AG+ ++ +L + P +V
Sbjct: 173 HLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAV 232
Query: 522 KEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDGAYT-IRKAQLKDAGVYECE 577
E V + C VP TW T V+ + G + +AQ DAGVY C+
Sbjct: 233 MEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCK 292
Query: 578 SKNKVGSQLRSLTLDV 593
+ N VG+ ++ LDV
Sbjct: 293 ASNAVGAAEKATRLDV 308
Score = 66.6 bits (161), Expect = 7e-11
Identities = 87/373 (23%), Positives = 145/373 (38%), Gaps = 48/373 (12%)
Query: 228 ISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNG-------NLQHLSGNATLTLIA 280
++VN S+ +V++ C + G P P I W L NG LQ L L +
Sbjct: 1573 VTVNASS------TVSLQCPALGNPVPTISW---LQNGLPFSPSPRLQVLEDGQVLQVST 1623
Query: 281 MRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP--EIEMSGGLVNGSSVTVSCKVPSV 338
+ D+ Y+C N G K L VQ PR ++E ++N SSV++ C V
Sbjct: 1624 AEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN-SSVSLPC---DV 1679
Query: 339 YPLDRLEIELLKGETIL---ENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKL 395
+ E+ K L E + L T L L + + T E A Q +
Sbjct: 1680 HAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLV 1739
Query: 396 HIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWS 455
+ + P RQ+ + P+D ++ G ++C + P P + W
Sbjct: 1740 QLSVL-VPPAFRQAPR------GPQDAV-------LVRVGDKAVLSCETDALPEPTVTWY 1785
Query: 456 RQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDI 511
+ + Q L L + ++ D G+Y C+ N AG + + L +QV P
Sbjct: 1786 KDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQV-PPTF 1844
Query: 512 KLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDT-VLKSIDGAYTIRKAQ 567
+ + S G ++++C VP TW+ + E+ + S G + + Q
Sbjct: 1845 ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQ 1904
Query: 568 LKDAGVYECESKN 580
AG Y C ++N
Sbjct: 1905 PAQAGTYTCVAEN 1917
Score = 60.1 bits (144), Expect = 6e-09
Identities = 91/422 (21%), Positives = 163/422 (38%), Gaps = 46/422 (10%)
Query: 210 VRQAVKELQVYISPKNTVI-----SVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK--- 261
V + K Q+ + T++ S + + +++ C + P+P I W K
Sbjct: 1240 VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 1299
Query: 262 -LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR----DPE 316
+ N+Q L G L ++ + ED+G Y C N +G+ K + V P DP
Sbjct: 1300 FEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPL 1359
Query: 317 IEMSGGLVN---GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKS 373
E+ V S++T+ C+ +V P + + T ++ L + + ++
Sbjct: 1360 AEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQ--- 1416
Query: 374 LEMTFIPT-IEDTGKAL-VCQAKLHIDDMEFEPK-------QRQSTQTLYVNVAPRDTTV 424
PT + D+G+ L V DD +F Q+ + + R+
Sbjct: 1417 ------PTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEA 1470
Query: 425 L--VSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTK 478
V+ + E + + C + P P + W R+ E+ L L + +
Sbjct: 1471 RGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVR 1530
Query: 479 MEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTC---GN 535
E++G Y C+ N+ G EL++ P + T E V + +S C GN
Sbjct: 1531 AENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN 1590
Query: 536 -VPE-TWIILKKKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLD 592
VP +W+ + DG + A++ DA Y C ++N+ GS + TL
Sbjct: 1591 PVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLR 1650
Query: 593 VQ 594
VQ
Sbjct: 1651 VQ 1652
Score = 58.9 bits (141), Expect = 1e-08
Identities = 82/396 (20%), Positives = 139/396 (35%), Gaps = 65/396 (16%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKL-------------------DNGNLQHLSGNATLTLI 279
G S+T+ C + G P PEI W K G + L +L
Sbjct: 33 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 92
Query: 280 AMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVY 339
++ DSG+Y C N G +++ L+V P SV + V
Sbjct: 93 RIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP---------------SVLGAGAAQEVL 137
Query: 340 PLDRLEIEL--LKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHI 397
L ++EL +E+ +D L+ +++ G+ L H+
Sbjct: 138 GLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQ------VQEDGQVLRITGS-HV 190
Query: 398 DD------MEFEPKQRQSTQ-TLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAP 450
D + F P +Q+ L V+ P + + E V + C ++G P P
Sbjct: 191 GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP 250
Query: 451 KILWSRQLPNGELQPLSENATLT-------LISTKMEDSGVYLCEGINQAGRSRKEVELI 503
I W + +G L P S T L + D+GVY C+ N G + K L
Sbjct: 251 NITWFK---DGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLD 307
Query: 504 IQVTPKDIKLTAFP-SESVKEGDTVIISCTCGNVPETWIILKKK----AETGDTVLKSID 558
+ V P P G V + C P + + AE+ ++ L++
Sbjct: 308 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG 367
Query: 559 GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
+ +G+Y C + + G + +++VQ
Sbjct: 368 SVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQ 403
Score = 57.4 bits (137), Expect = 4e-08
Identities = 79/372 (21%), Positives = 144/372 (38%), Gaps = 30/372 (8%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKK----LDNG-NLQHLSGNATLTLIAMRMEDSGIYVCEG 293
G V + C + G+P P++ W+K L G +LQ L + + D G Y C
Sbjct: 141 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 200
Query: 294 VNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGET 353
+ G+ ++ +L V A P + GS+ T V D L L +
Sbjct: 201 FSPAGQQARDFQLRVHAPPT----------IWGSNETGEVAVME----DHLVQLLCEARG 246
Query: 354 I-LENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQT 412
+ NI + +D + K + ++ G+A A ++ +
Sbjct: 247 VPTPNITWFKDGALLPTSTKVVYTRGGRQLQ-LGRAQSSDAGVYTCKASNAVGAAEKATR 305
Query: 413 LYVNVAPRDTTVLVSPSSILE-EGSSVNMTCLSQGFPAPKILWSRQ-LP---NGELQPLS 467
L V V P P + G V + C+++G P+P + W + LP + E + +
Sbjct: 306 LDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLET 365
Query: 468 ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTV 527
+ + L L S SG+Y C + AG + + + +QV P+ + + G +
Sbjct: 366 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPL 425
Query: 528 IISCTCGNVPE---TWIILKKKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVG 583
+ C P W+ + AE V + G I +L +G++ C++ N+ G
Sbjct: 426 ELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 485
Query: 584 SQLRSLTLDVQG 595
+ + + V G
Sbjct: 486 TAGAEVEVSVHG 497
Score = 53.9 bits (128), Expect = 4e-07
Identities = 82/331 (24%), Positives = 131/331 (39%), Gaps = 60/331 (18%)
Query: 29 TTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFG 88
T P R L ++GD + L C+ G +P W T D P+ V+ + STL VS
Sbjct: 2851 TLPGDRSL-RLGDRLWLRCAARGSPTPRIGW-TVNDRPVTEGVSEQDGGSTLQRAAVSRE 2908
Query: 89 NEHSYLCTATCESR------------KLEKGIQVEIYSFPKDPEIHLSGPLEA-----GK 131
+ +Y+C A E+R K +Q E +S+ +P + G ++ G
Sbjct: 2909 DSGTYVCWA--ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP---VGGSIQLDCVVRGD 2963
Query: 132 PITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGK 191
P+ + D P L+G HL R L+ SL + T +D G+
Sbjct: 2964 PVPDIHWIKDGLP--------LRGSHL-----------RHQLQNGSLTIRRTER-DDAGR 3003
Query: 192 VLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTK-LQEGGSVTMTCSSEG 250
C A+ +EM K++ + + V V P ++ G V + C + G
Sbjct: 3004 YQ-CLAE---NEMG-------VAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATG 3052
Query: 251 LPAPEIFW---SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELI 307
P P I W + L + +L L + D+G Y C NL+G L+
Sbjct: 3053 EPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLV 3112
Query: 308 VQAFPRDPEIEMSGGLVNGSSVTVSCKVPSV 338
V+ P+ M+ G++NG V+ SV
Sbjct: 3113 VRGEPQGSWGSMT-GVINGRKFGVATLNTSV 3142
Score = 52.8 bits (125), Expect = 1e-06
Identities = 53/209 (25%), Positives = 80/209 (38%), Gaps = 34/209 (16%)
Query: 419 PRDTTVLVSPSSILEEGSSVNMT----------CLSQGFPAPKILWSR--QLPN------ 460
P T V P SI E+G N++ C + GFP P+I+W + QL
Sbjct: 7 PLLNTGSVVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWA 66
Query: 461 -----------GELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK 509
G + L E +L + DSG+Y C NQAG ++++ L++ P
Sbjct: 67 GYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPS 126
Query: 510 DIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAET----GDTVLKSIDG-AYTIR 564
+ A G V + C VP + K + G + DG I
Sbjct: 127 VLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRIT 186
Query: 565 KAQLKDAGVYECESKNKVGSQLRSLTLDV 593
+ + D G Y+C + + G Q R L V
Sbjct: 187 GSHVGDEGRYQCVAFSPAGQQARDFQLRV 215
Score = 51.6 bits (122), Expect = 2e-06
Identities = 49/209 (23%), Positives = 81/209 (38%), Gaps = 27/209 (12%)
Query: 434 EGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLS---------ENATLTLISTKMEDSGV 484
E +SV + CL+ G P P + W + QP+S + L + ++ D+G
Sbjct: 617 ENASVTLECLASGVPPPDVSWFK-----GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGS 671
Query: 485 YLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILK 544
Y C N AG + L + V P+ + P V V ++C P ++
Sbjct: 672 YRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG-PVLVNTPVRLTCNATGAPSPTLMWL 730
Query: 545 KK----AETGDTVLKSIDG--AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ---- 594
K + G L+ G T+ A+ D+G Y C + + VG + + L V
Sbjct: 731 KDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 790
Query: 595 --GRENNKDYFSPELLVLYFASSLIIPAI 621
G E N + E + L S + P +
Sbjct: 791 ILGEELNVSVVANESVALECQSHAMPPPV 819
Score = 51.6 bits (122), Expect = 2e-06
Identities = 79/320 (24%), Positives = 123/320 (38%), Gaps = 69/320 (21%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWS---KKLDNGNLQHLSGN 273
L + + P T + + S +L G + + C++ G P P I W+ + + G + G
Sbjct: 2841 LTILVLPVFTTLPGDRSLRL--GDRLWLRCAARGSPTPRIGWTVNDRPVTEG-VSEQDGG 2897
Query: 274 ATLTLIAMRMEDSGIYVCEGVNLIGKNR-------KEVELIVQAFPRDPEIEMSGGLVNG 326
+TL A+ EDSG YVC N +G+ + KE ++Q +E GG +
Sbjct: 2898 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP-VLQGEAFSYLVEPVGGSIQL 2956
Query: 327 SSVTVSCKVPSVYPL-DRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDT 385
V VP ++ + D L L+G + L+N SL T T D
Sbjct: 2957 DCVVRGDPVPDIHWIKDGLP---LRGSHLRHQ-----------LQNGSL--TIRRTERDD 3000
Query: 386 GKALVCQAKLHIDDMEFEPKQ----RQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMT 441
C A+ ++M K QS V P+D TV G V +
Sbjct: 3001 AGRYQCLAE---NEMGVAKKVVILVLQSAPVFQVE--PQDMTV--------RSGDDVALR 3047
Query: 442 CLSQGFPAPKILWS------------RQLPNGELQPLSENATLTLISTKMEDSGVYLCEG 489
C + G P P I W R LP+G +L L + + D+G Y C
Sbjct: 3048 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDG---------SLWLENVETGDAGTYDCVA 3098
Query: 490 INQAGRSRKEVELIIQVTPK 509
N G + L+++ P+
Sbjct: 3099 HNLLGSATARAFLVVRGEPQ 3118
>gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens]
Length = 956
Score = 95.9 bits (237), Expect = 1e-19
Identities = 140/606 (23%), Positives = 233/606 (38%), Gaps = 78/606 (12%)
Query: 28 ETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSF 87
E E Y + G+++ LTC TG P W S + + TL + +
Sbjct: 43 ERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQR 102
Query: 88 GNEHSYLCTATCE-SRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKP-------ITVKCSV 139
Y C A K I+V++Y + DP + + + K + ++C V
Sbjct: 103 HQGGRYYCKAENGLGSPAIKSIRVDVY-YLDDPVVTVHQSIGEAKEQFYYERTVFLRC-V 160
Query: 140 ADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKL 199
A+ P R + QE L K +E E FT I K+ R +
Sbjct: 161 ANSNPPVRYS--------WRRGQEVLLQGSDKGVEI--YEPFFTQGETKILKLKNLRPQD 210
Query: 200 HIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKL--------QEGGSVTMTC-SSEG 250
+ + + +VR +S + + + +PS KL G ++T+ C ++ G
Sbjct: 211 YAN-YSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGG 269
Query: 251 LPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGK-NRKEVELIVQ 309
PAP + W + + + TLT+ A+ +D+G Y C N +G +K +IV+
Sbjct: 270 EPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVR 329
Query: 310 AFPR-------DPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFL- 361
A + DP + G V +SC+V +V P + L K L + E +
Sbjct: 330 ALKKGRFWITPDP-YHKDDNIQIGREVKISCQVEAV-PSEELTFSWFKNGRPLRSSERMV 387
Query: 362 ---EDTDMK----SLENKSLEMTFIPTIEDTGKALVCQAKLH---IDDMEFEPKQRQSTQ 411
D D+ +L+ L+ T T C A L I D+ + ST
Sbjct: 388 ITQTDPDVSPGTTNLDIIDLKFTDFGT-------YTCVASLKGGGISDISIDVNISSST- 439
Query: 412 TLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR-----QLPNGELQPL 466
V P T + EG ++ + C G P P ILWSR +P+G +Q
Sbjct: 440 -----VPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQME 494
Query: 467 SENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ--------VTPKDIKLTAFPS 518
S + TL +++ E SG+Y C+ G + K E ++Q V P +++
Sbjct: 495 SYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQD 554
Query: 519 ESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECES 578
SV V+ + + W + K TG + Y ++ ++ GVY C
Sbjct: 555 RSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYT-EYAVKSLSNENYGVYNCSI 613
Query: 579 KNKVGS 584
N+ G+
Sbjct: 614 INEAGA 619
Score = 60.1 bits (144), Expect = 6e-09
Identities = 84/398 (21%), Positives = 156/398 (39%), Gaps = 56/398 (14%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSG---NATLTLIAMRMEDSGIYVCE 292
++EG ++ +TC G P P+I W+K + + + N TL + ++ G Y C+
Sbjct: 52 IREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCK 111
Query: 293 GVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGS-------SVTVSCKV----PSVYPL 341
N +G + + + DP + + + +V + C P Y
Sbjct: 112 AENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSW 171
Query: 342 DRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDME 401
R + LL+G + +E E + E K L++ + + + + + + +
Sbjct: 172 RRGQEVLLQGSD--KGVEIYEPFFTQG-ETKILKLKNLRPQDYANYSCIASVRNVCNIPD 228
Query: 402 FEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGF-PAPKILWSRQLPN 460
R S +T A +LV ++ G ++ + C++ G PAP + W R
Sbjct: 229 KMVSFRLSNKT-----ASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGT 283
Query: 461 GELQPLSENATLTLISTKMEDSGVYLCEGINQAGR-SRKEVELIIQVTPKD-IKLTAFP- 517
+ + TLT+ + +D+G Y C N G ++K +I++ K +T P
Sbjct: 284 LPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPY 343
Query: 518 --SESVKEGDTVIISCTCGNVP------------------ETWIILKKKAET--GDTVLK 555
++++ G V ISC VP E +I + + G T L
Sbjct: 344 HKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLD 403
Query: 556 SIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
ID +T D G Y C + K G + +++DV
Sbjct: 404 IIDLKFT-------DFGTYTCVASLK-GGGISDISIDV 433
Score = 42.4 bits (98), Expect = 0.001
Identities = 40/179 (22%), Positives = 75/179 (41%), Gaps = 24/179 (13%)
Query: 432 LEEGSSVNMTCLSQGFPAPKILWS-----RQLPNGELQPLSEN--------ATLTLISTK 478
++ G V ++C + P+ ++ +S R L + E +++ L +I K
Sbjct: 349 IQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLK 408
Query: 479 MEDSGVYLC-EGINQAGRSRKEVELIIQVTPKDIKLTAFPSES---VKEGDTVIISCTCG 534
D G Y C + G S +++ I + LT +S +EGDT+ + C
Sbjct: 409 FTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVT 468
Query: 535 NVPETWIILKKKAET------GDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLR 587
P+ IIL +A+ G ++S DG I + +G+Y C++ G ++
Sbjct: 469 GKPKP-IILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVK 526
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 94.7 bits (234), Expect = 2e-19
Identities = 143/622 (22%), Positives = 248/622 (39%), Gaps = 92/622 (14%)
Query: 26 KIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGT--------- 76
KIE E+ + G + + C TG +P SW S +N + ++ +
Sbjct: 2244 KIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVV 2303
Query: 77 --TSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKD--PEIHLSGPLEAGKP 132
TL N V E Y C A + K E ++V++ + P + +L+ + G
Sbjct: 2304 FNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDV 2363
Query: 133 ITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKV 192
+TV C KG+ + K K + T S + I G +
Sbjct: 2364 VTVACEA--------------KGEPMPKVTWL--SPTNKVIPTSSEKYQ----IYQDGTL 2403
Query: 193 LVCRAKLHIDEMDSVPTVRQAVKE------LQVYISPKNTVISVNPSTKLQE----GGSV 242
L+ +A+ D + VR + E + V + P + NP T ++E G
Sbjct: 2404 LIQKAQ-RSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRK 2462
Query: 243 TMTCSSEGLPAPEIFWSKKLD-------NGNLQHLSGNATLTLIAMRMEDSGIYVCEGVN 295
+ C +EG+P P + W+ GN + GN +L + ++R DS VC N
Sbjct: 2463 LIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARN 2522
Query: 296 LIGKNRKEVELIV-----QAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLK 350
G+ R ++L V + DP E + G +++++C P L + +L
Sbjct: 2523 EGGEARLILQLTVLEPMEKPIFHDPISEKITAMA-GHTISLNCSAAGT-PTPSL-VWVLP 2579
Query: 351 GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQST 410
T L++ + L+ K+ + L ++ + ++ D G A C A+ E
Sbjct: 2580 NGTDLQSGQQLQRFYHKA--DGMLHISGLSSV-DAG-AYRCVARNAAGHTE-------RL 2628
Query: 411 QTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNG-ELQ----- 464
+L V + P + SI+ G ++ + C G + W+ LPNG L+
Sbjct: 2629 VSLKVGLKPEANKQYHNLVSIIN-GETLKLPCTPPGAGQGRFSWT--LPNGMHLEGPQTL 2685
Query: 465 ---PLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESV 521
L +N TLT+ + D G Y+C + G S + +I+ P I P
Sbjct: 2686 GRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYT 2745
Query: 522 KEGDTVIISCTCGNVPE---TWIILKK-------KAETGDTVLKSIDGAYTIRKAQLKDA 571
+ G+TV ++C +P+ TW + K +A G+ TI+ A +DA
Sbjct: 2746 RPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDA 2805
Query: 572 GVYECESKNKVGSQLRSLTLDV 593
G Y+C +KN +GS ++ + V
Sbjct: 2806 GFYKCMAKNILGSDSKTTYIHV 2827
Score = 92.8 bits (229), Expect = 9e-19
Identities = 136/604 (22%), Positives = 243/604 (40%), Gaps = 81/604 (13%)
Query: 39 IGDSVSLTCSTTGCESPFFSW------RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHS 92
+GD++++ C G +P SW Q SP+ G++T TL++ SF +
Sbjct: 1964 LGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLH-ENRTLSIKEASFSDRGV 2022
Query: 93 YLCTATCESRKLEKGIQVEIYSFPKDPEIHLSG----PLEAGKPITVKCSVADVYPFDRL 148
Y C A+ + I++ + + P P IH L G I + C+ A P +
Sbjct: 2023 YKCVASNAAGADSLAIRLHVAALP--PVIHQEKLENISLPPGLSIHIHCT-AKAAPLPSV 2079
Query: 149 EIDLLKGDHLMKSQEFLED----ADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEM 204
L G + SQ FL +L ++L +D G+ A L
Sbjct: 2080 RWVLGDGTQIRPSQ-FLHGNLFVFPNGTLYIRNL------APKDSGRYECVAANL----- 2127
Query: 205 DSVPTVRQAVKELQVYISPKNT-VISVNP-STKLQEGGSVTMTCSSEGLPAPEIFW---S 259
V + R+ V +L V + N + +P T ++ GG++ + CS+ G P P I W S
Sbjct: 2128 --VGSARRTV-QLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPS 2184
Query: 260 KKLDNGNLQHLS-----GNATLTLIAMRMEDSGIYVCEGVNLIGKNR--KEVELIVQAFP 312
K++ + S N TL + ++ +D+G Y+C N +G + +V+++++
Sbjct: 2185 KRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAK 2244
Query: 313 RDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKS---- 368
+ + E + G + V C V + P + L G + F++ D
Sbjct: 2245 IEHKEENDHKVFYGGDLKVDC-VATGLPNPEISWSLPDGSLV---NSFMQSDDSGGRTKR 2300
Query: 369 ---LENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVL 425
N +L + E+ + ++ D+M K + T+ R+ T L
Sbjct: 2301 YVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATI------RNKTYL 2354
Query: 426 VSPSSILEEGSSVNMTCLSQGFPAPKILW----SRQLP-NGELQPLSENATLTLISTKME 480
+ G V + C ++G P PK+ W ++ +P + E + ++ TL + +
Sbjct: 2355 AVQ---VPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRS 2411
Query: 481 DSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKE----GDTVIISCTCGNV 536
DSG Y C N AG RK V + + V P I P +V+E G +I C +
Sbjct: 2412 DSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGI 2471
Query: 537 PETWI-------ILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSL 589
P + ++ G+ + +G+ IR + D+ C ++N+ G L
Sbjct: 2472 PTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLIL 2531
Query: 590 TLDV 593
L V
Sbjct: 2532 QLTV 2535
Score = 80.9 bits (198), Expect = 3e-15
Identities = 105/437 (24%), Positives = 178/437 (40%), Gaps = 74/437 (16%)
Query: 214 VKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQH---- 269
V ++ V + P K+ GG + + C + GLP PEI WS L +G+L +
Sbjct: 2233 VLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWS--LPDGSLVNSFMQ 2290
Query: 270 ------------LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRD--P 315
+ N TL + M + G Y C N +GK+ V + V P
Sbjct: 2291 SDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRN 2350
Query: 316 EIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLE 375
+ ++ + G VTV+C+ KGE + + +L T+ K + S +
Sbjct: 2351 KTYLAVQVPYGDVVTVACEA--------------KGEP-MPKVTWLSPTN-KVIPTSSEK 2394
Query: 376 MTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQS------TQTLYVNVAPRDTTVLVSPS 429
I G L+ +A+ D + R S T ++VNV P +P
Sbjct: 2395 YQ----IYQDGTLLIQKAQ-RSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPI 2449
Query: 430 SILEE----GSSVNMTCLSQGFPAPKILWSRQLPNGELQP---------LSENATLTLIS 476
+ + E GS + C ++G P P++LW+ P G + P + N +L + S
Sbjct: 2450 TTVREIAAGGSRKLIDCKAEGIPTPRVLWA--FPEGVVLPAPYYGNRITVHGNGSLDIRS 2507
Query: 477 TKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFP-SESVKE--GDTVIISCTC 533
+ DS +C N+ G +R ++L + + P + + P SE + G T+ ++C+
Sbjct: 2508 LRKSDSVQLVCMARNEGGEARLILQLTV-LEPMEKPIFHDPISEKITAMAGHTISLNCSA 2566
Query: 534 GNVPE---TWIILK-KKAETGDTVLK---SIDGAYTIRKAQLKDAGVYECESKNKVGSQL 586
P W++ ++G + + DG I DAG Y C ++N G
Sbjct: 2567 AGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTE 2626
Query: 587 RSLTLDVQGR-ENNKDY 602
R ++L V + E NK Y
Sbjct: 2627 RLVSLKVGLKPEANKQY 2643
Score = 72.8 bits (177), Expect = 9e-13
Identities = 108/453 (23%), Positives = 182/453 (40%), Gaps = 78/453 (17%)
Query: 221 ISPKNTVISVNPSTKLQEGGSVTM-TCSSEGLPAPEIFWSK------KLDNGNLQHLS-- 271
+ K +++ +P T + T+ C + G P P + W+K N +Q
Sbjct: 1849 LGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVL 1908
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTV 331
N TL + ++++D G Y+C NL G +R V L V + P+I S + VT
Sbjct: 1909 KNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTV--QQPQILAS----HYQDVT- 1961
Query: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC 391
VY D + +E L T I ++ ++ + T P G+ +
Sbjct: 1962 ------VYLGDTIAMECLAKGTPAPQISWI-------FPDRRVWQTVSPV---EGRITLH 2005
Query: 392 QAK-LHIDDMEFEPKQRQSTQTLYVNVAPRDTT-----VLVSPSSILEE---------GS 436
+ + L I + F R + + N A D+ V P I +E G
Sbjct: 2006 ENRTLSIKEASF--SDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGL 2063
Query: 437 SVNMTCLSQGFPAPKILW---------SRQLPNGELQPLSENATLTLISTKMEDSGVYLC 487
S+++ C ++ P P + W Q +G L + N TL + + +DSG Y C
Sbjct: 2064 SIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF-VFPNGTLYIRNLAPKDSGRYEC 2122
Query: 488 EGINQAGRSRKEVELIIQVTPKDIKLTAFPSE--SVKEGDTVIISCTCGNVPETWIILKK 545
N G +R+ V+L +Q + ++T V+ G T+ + C+ P I+ +
Sbjct: 2123 VAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRL 2182
Query: 546 KAETGDTVLKSID--------GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV---- 593
++ L S D G ++ KDAG Y C ++NKVG L +DV
Sbjct: 2183 PSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKP 2242
Query: 594 ---QGRENN--KDYFSPELLVLYFASSLIIPAI 621
+ +E N K ++ +L V A+ L P I
Sbjct: 2243 AKIEHKEENDHKVFYGGDLKVDCVATGLPNPEI 2275
Score = 67.4 bits (163), Expect = 4e-11
Identities = 99/466 (21%), Positives = 181/466 (38%), Gaps = 71/466 (15%)
Query: 186 IEDIGKVLVCRAKLH-IDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTM 244
++D G+ + + LH +D M V L V + + S + G ++ M
Sbjct: 1920 VQDRGQYMCTASNLHGLDRM---------VVLLSVTVQQPQILASHYQDVTVYLGDTIAM 1970
Query: 245 TCSSEGLPAPEIFW---------SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVN 295
C ++G PAP+I W + G + L N TL++ D G+Y C N
Sbjct: 1971 ECLAKGTPAPQISWIFPDRRVWQTVSPVEGRIT-LHENRTLSIKEASFSDRGVYKCVASN 2029
Query: 296 LIGKNRKEVELIVQAFPRDPEIEMSG----GLVNGSSVTVSCKVPSVYPLDRLEIELLKG 351
G + + L V A P P I L G S+ + C + PL + L G
Sbjct: 2030 AAGADSLAIRLHVAALP--PVIHQEKLENISLPPGLSIHIHCTAKAA-PLPSVRWVLGDG 2086
Query: 352 ETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPK---QRQ 408
T + +FL ++ N +L + + +D+G+ C A + + QR
Sbjct: 2087 -TQIRPSQFLHG-NLFVFPNGTLYIRNLAP-KDSGR-YECVAANLVGSARRTVQLNVQRA 2142
Query: 409 STQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL----- 463
+ +PR T V G ++ + C + G P P+ILW +LP+ +
Sbjct: 2143 AANARITGTSPRRTDV--------RYGGTLKLDCSASGDPWPRILW--RLPSKRMIDALF 2192
Query: 464 -----QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPS 518
+ N TL + S +D+G YLC N+ G +++ + + P I+
Sbjct: 2193 SFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEEND 2252
Query: 519 ESVKEGDTVIISCTCGNVPE---TWII--------LKKKAETGDTVLKSI---DGAYTIR 564
V G + + C +P +W + + ++G + + +G
Sbjct: 2253 HKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFN 2312
Query: 565 KAQLKDAGVYECESKNKVGS---QLRSLTLDVQGRENNKDYFSPEL 607
+ +++ G Y C ++N+VG ++R + NK Y + ++
Sbjct: 2313 EVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQV 2358
Score = 45.1 bits (105), Expect = 2e-04
Identities = 47/202 (23%), Positives = 83/202 (41%), Gaps = 35/202 (17%)
Query: 407 RQSTQTLYVNVAP-----RDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNG 461
RQ+ +V + P RD TVL EG ++C + +P I W LP+G
Sbjct: 469 RQARGRSWVMIEPSGAVQRDQTVL--------EGGPCQLSCNVKASESPSIFWV--LPDG 518
Query: 462 EL--QPLSE---------NATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKD 510
+ P+ + + L + S + DSG+Y C + R +++Q
Sbjct: 519 SILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQ 578
Query: 511 IKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKK-----AETGDTVLKSIDGAYT 562
+ G++V + C +PE +WI+ ++ A T + +G +
Sbjct: 579 PAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLP-NGTLS 637
Query: 563 IRKAQLKDAGVYECESKNKVGS 584
I K Q+ D+G Y C + N+ G+
Sbjct: 638 IPKVQVSDSGYYRCVAVNQQGA 659
Score = 40.4 bits (93), Expect = 0.005
Identities = 40/144 (27%), Positives = 65/144 (45%), Gaps = 23/144 (15%)
Query: 173 LETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTV-ISVN 231
L KS+E + + + + I +V DEMD + R V+ + K+TV I N
Sbjct: 540 LRIKSMEPSDSGLYQCIAQVR--------DEMDRM-VYRVLVQSPSTQPAEKDTVTIGKN 590
Query: 232 PSTKLQEGGSVTMTCSSEGLPAPEIFWS-------KKLDNGNLQHLSGNATLTLIAMRME 284
P G SVT+ C++ +P + W L N + ++ N TL++ +++
Sbjct: 591 P------GESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVS 644
Query: 285 DSGIYVCEGVNLIGKNRKEVELIV 308
DSG Y C VN G + V + V
Sbjct: 645 DSGYYRCVAVNQQGADHFTVGITV 668
Score = 35.8 bits (81), Expect = 0.13
Identities = 68/350 (19%), Positives = 130/350 (37%), Gaps = 44/350 (12%)
Query: 30 TPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPV---- 85
+P+ Y +I +TC ESP R++ + + G+ L +
Sbjct: 258 SPKKLYKHEIHKLKDMTCLKPSIESPLRQNRSRSIEEEQEQEEDGGSQLILEKFQLPQWS 317
Query: 86 ---SFGNEHSYLCTATCESRKLEKGIQVEI-YSFPKDPEIHLSGPLEAGKPIT----VKC 137
+ +EH + C+ +K ++ + + P D +I+ + L+ P+T K
Sbjct: 318 ISLNMTDEHGNMVNLVCDIKKPMDVYKIHLNQTDPPDIDINATVALDFECPMTRENYEKL 377
Query: 138 SVADVYPFD---RLEIDLLKGDHLMKSQEFLEDADRKSLETKSL--------EVTFTPVI 186
Y + +L +L+ S ++ +DAD ++L + E P I
Sbjct: 378 WKLIAYYSEVPVKLHRELMLSKDPRVSYQYRQDADEEALYYTGVRAQILAEPEWVMQPSI 437
Query: 187 E-------DIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEG 239
+ K ++ + S RQA V I P +V + EG
Sbjct: 438 DIQLNRRQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIEPSG---AVQRDQTVLEG 494
Query: 240 GSVTMTCSSEGLPAPEIFW---------SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYV 290
G ++C+ + +P IFW + D + + + L + +M DSG+Y
Sbjct: 495 GPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQ 554
Query: 291 CEGVNLIGKNRKEVELIVQAFPRDP--EIEMSGGLVNGSSVTVSCKVPSV 338
C +R ++VQ+ P + ++ G G SVT+ C ++
Sbjct: 555 CIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
Score = 34.3 bits (77), Expect = 0.37
Identities = 20/77 (25%), Positives = 31/77 (40%), Gaps = 7/77 (9%)
Query: 435 GSSVNMTCLSQGFPAPKILWS-------RQLPNGELQPLSENATLTLISTKMEDSGVYLC 487
G SV + C + P + W L N + N TL++ ++ DSG Y C
Sbjct: 592 GESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRC 651
Query: 488 EGINQAGRSRKEVELII 504
+NQ G V + +
Sbjct: 652 VAVNQQGADHFTVGITV 668
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 92.4 bits (228), Expect = 1e-18
Identities = 91/373 (24%), Positives = 146/373 (39%), Gaps = 47/373 (12%)
Query: 240 GSVTMTCSSEGLPAPEIFWSKK------LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEG 293
G+ + C G + W K D + + G A+L +I + M D+G + C
Sbjct: 4128 GTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRA 4187
Query: 294 VNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLD----RLEIELL 349
N +G LIVQ P S ++ GS+V + PL + EL+
Sbjct: 4188 TNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELV 4247
Query: 350 KGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQS 409
G + E LE + L S T+ + + + C A L + +
Sbjct: 4248 SGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKE---------- 4297
Query: 410 TQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPL 466
P + PS +L++G + + C G P KI W R++ +
Sbjct: 4298 ---------PATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRM 4348
Query: 467 S---ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP---KDIKLTAFPSES 520
S A L L +EDSG Y+CE N+AG +I++ +P K+ K P E
Sbjct: 4349 SFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFK----PIEV 4404
Query: 521 VKEGDTVIISCTCGNVP--ETWI---ILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYE 575
+KE D ++++ G P TW + + T ++ + I K DAG Y+
Sbjct: 4405 LKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQ 4464
Query: 576 CESKNKVGSQLRS 588
C N+VGS + S
Sbjct: 4465 CRVTNEVGSSICS 4477
Score = 84.0 bits (206), Expect = 4e-16
Identities = 133/598 (22%), Positives = 236/598 (39%), Gaps = 87/598 (14%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSY 93
A +GDSVSL C G SW T++ + +TL N V+ + Y
Sbjct: 6090 AAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEY 6149
Query: 94 LCTA-----TCESRKL----EKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYP 144
C A T S+ + E+ + KD E G P+T+ C + P
Sbjct: 6150 TCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIE------QTVGLPVTLTCRLNGSAP 6203
Query: 145 FDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEM 204
+++ + L++ E L+ + ++ T L++ T + C A +
Sbjct: 6204 ---IQVCWYRDGVLLRDDENLQTSFVDNVAT--LKILQTDLSH--SGQYSCSASNPLGTA 6256
Query: 205 DSVPTVRQAVKELQVYISPKNTVISVNP-STKLQEGGSVTMTCSSEGLPAPEIFWSKKLD 263
S + R +E K+ + P S + G S C G I WSK D
Sbjct: 6257 SS--SARLTARE-----PKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSK--D 6307
Query: 264 NGNLQHLSGNATLT---------LIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR- 313
N ++ GN T+T ++ + DSG Y C+ N +GK+ +L V+ P+
Sbjct: 6308 NKEIRP-GGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKF 6366
Query: 314 DPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILE-----NIEFLEDTDMKS 368
++E S G S+ + CK+ +++ + ++ L N+ F+ + +
Sbjct: 6367 VKKLEASKVAKQGESIQLECKISG---SPEIKVSWFRNDSELHESWKYNMSFINSVALLT 6423
Query: 369 LENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSP 428
+ S ED+G +C+A + D S T AP T SP
Sbjct: 6424 INEAS--------AEDSGD-YICEAHNGVGD--------ASCSTALTVKAPPVFTQKPSP 6466
Query: 429 SSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLSE---NATLTLISTKMEDS 482
L +GS V + C G P +++W +Q+ N + ++ + +L +++ + D
Sbjct: 6467 VGAL-KGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDV 6525
Query: 483 GVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTC-GNVPETWI 541
G Y C+ N+ G + + P+ +K + S + GD V + G P + +
Sbjct: 6526 GEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLI--GDAVELRAIVEGFQPISVV 6583
Query: 542 ILKKKA----ETGDTVLKSIDGAYTIR--KAQLKDAGVYECESKNKVGSQLRSLTLDV 593
LK + E+ +T + ID T++ + ++G Y C+ KN G + S L V
Sbjct: 6584 WLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTV 6641
Score = 75.5 bits (184), Expect = 1e-13
Identities = 88/400 (22%), Positives = 155/400 (38%), Gaps = 51/400 (12%)
Query: 223 PKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDN------GNLQHLSGNATL 276
P V + S ++G S+ + C G P ++ W + N+ ++ A L
Sbjct: 6363 PPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALL 6422
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVP 336
T+ EDSG Y+CE N +G L V+A P + G + GS V + C++
Sbjct: 6423 TINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEIS 6482
Query: 337 SVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLH 396
P + + ++ D K + N S + DT ++
Sbjct: 6483 GTPPFEVVWVK-----------------DRKQVRN-SKKFKITSKHFDTSLHILNLEASD 6524
Query: 397 IDDMEFEPKQRQSTQTLYVNVA----PRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKI 452
+ + + + T +V PR L S+++ G +V + + +GF +
Sbjct: 6525 VGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLI--GDAVELRAIVEGFQPISV 6582
Query: 453 LWSRQLPNGELQPLSEN---------ATLTLISTKMEDSGVYLCEGINQAGRSRKEVELI 503
+W + GE+ SEN ATL L S + +SG Y+C+ N AG +E +
Sbjct: 6583 VWLKD--RGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAG--MRECSAV 6638
Query: 504 IQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWI----ILKKKAETGDTVLKS 556
+ V + +V G+ + C PE W L ++ T +
Sbjct: 6639 LTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINK 6698
Query: 557 IDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGR 596
+ + I A++ D G+Y E KN VG ++++ V R
Sbjct: 6699 V-ASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDR 6737
Score = 74.3 bits (181), Expect = 3e-13
Identities = 91/408 (22%), Positives = 156/408 (38%), Gaps = 66/408 (16%)
Query: 223 PKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGN---LQHLSGNATL 276
P + V V+PS + G S + C +G P ++ W +K+L N + ++ A L
Sbjct: 3736 PPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAIL 3795
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVP 336
+ +++EDSG Y CE VN +G + E++++ P + +V G++ + C+V
Sbjct: 3796 DITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVS 3855
Query: 337 SVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLH 396
P EI K D K + + F + K+LVC
Sbjct: 3856 GTGPF---EISWFK--------------DKKQIRSSKKYRLF------SQKSLVC----- 3887
Query: 397 IDDMEFEPKQRQSTQTLYVNVAPR----DTTVLVSPSSILEE--------GSSVNMTCLS 444
++ F + + N + T +L P + +++ G +V +
Sbjct: 3888 LEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAV 3947
Query: 445 QGFPAPKILWSRQLP----NGELQPLSENATLTLISTKMEDS--GVYLCEGINQAGRSRK 498
+G + W + +G+++ N LI ++ S G Y C N+AG
Sbjct: 3948 RGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTS 4007
Query: 499 EVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPET---W------IILKKKAET 549
ELI++ K I+ V GD + T PE W ++ KK
Sbjct: 4008 VGELIVKEPAKIIERAELIQ--VTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRI 4065
Query: 550 GDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRE 597
K+ A+L D+G Y E N+VGS T V R+
Sbjct: 4066 S---FKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRD 4110
Score = 73.9 bits (180), Expect = 4e-13
Identities = 115/503 (22%), Positives = 192/503 (38%), Gaps = 79/503 (15%)
Query: 127 LEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLE-DADRKSLETKSLEVT---- 181
+E G PI ++ + P + + +K ++L+ E KS + LE T
Sbjct: 6938 VETGSPIVLEATYTGTPP---ISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDY 6994
Query: 182 --FTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEG 239
++ +IE+ +C A + +V E +I P V +V G
Sbjct: 6995 AQYSCLIENEAGQDICEALV-------------SVLEPPYFIEPLEHVEAVI-------G 7034
Query: 240 GSVTMTCSSEGLPAPEIFWSK---KLDNG---NLQHLSGNATLTLIAMRMEDSGIYVCEG 293
T+ C +G P I W K KL + +Q + A+L + + D G Y C+
Sbjct: 7035 EPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKA 7094
Query: 294 VNLIGKNRKEVELIVQAFPRDPEIEMSGGLVN---GSSVTVSCKVPSVYPLDRLEIELLK 350
N +G L+++A P V+ G V C++ PL ++ K
Sbjct: 7095 DNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPL---QVSWYK 7151
Query: 351 GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQST 410
+L+ ++ +L+ +F+ + Q+ HI T
Sbjct: 7152 DGVLLK-------------DDANLQTSFVHNVATLQILQTDQS--HIGQYNCSASNPLGT 7196
Query: 411 QTLYVNVAPRDTTVL----VSPSSI-LEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQP 465
+ + + V + P S+ L G S C G KI W++ N E++P
Sbjct: 7197 ASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKD--NREIRP 7254
Query: 466 -------LSEN-ATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFP 517
L EN ATLT++ D+G Y C N AG+ +L +Q P+ IK P
Sbjct: 7255 GGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLE-P 7313
Query: 518 SESVKEGDTVIISCTCGNVPETWIILKKK----AETGDTVLKSIDGAYTIRKAQL--KDA 571
S VK+ + C G PE ++ K E+ + +D + L +D+
Sbjct: 7314 SRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDS 7373
Query: 572 GVYECESKNKVGSQLRSLTLDVQ 594
G Y CE+ N GS S +L V+
Sbjct: 7374 GDYTCEAHNAAGSASSSTSLKVK 7396
Score = 73.6 bits (179), Expect = 5e-13
Identities = 86/387 (22%), Positives = 155/387 (40%), Gaps = 55/387 (14%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSK------KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCE 292
G SV++ C G P + W K + ATL + + DSG Y C+
Sbjct: 6093 GDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCK 6152
Query: 293 GVNLIGKNRKEVELIVQAFPRDP-------EIEMSGGLVNGSSVTVSCKVPSVYPLDRLE 345
N IG + +Q P +IE + GL VT++C++ P+ +
Sbjct: 6153 AENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGL----PVTLTCRLNGSAPI---Q 6205
Query: 346 IELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPK 405
+ + +L + E L+ + + ++ + T + +G+ C A + +
Sbjct: 6206 VCWYRDGVLLRDDENLQTSFVDNVATLKILQT---DLSHSGQ-YSCSASNPLGTASSSAR 6261
Query: 406 --QRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL 463
R+ ++ + ++ P V+ G S + C G +I WS+ N E+
Sbjct: 6262 LTAREPKKSPFFDIKPVSIDVIA--------GESADFECHVTGAQPMRITWSKD--NKEI 6311
Query: 464 QPLSENATLTLISTKME---------DSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLT 514
+P N T+T + DSG Y C+ N G+ +L ++ PK +K
Sbjct: 6312 RP-GGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKL 6370
Query: 515 AFPSESVKEGDTVIISCTCGNVPE---TWI----ILKKKAETGDTVLKSIDGAYTIRKAQ 567
S+ K+G+++ + C PE +W L + + + + S+ TI +A
Sbjct: 6371 E-ASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSV-ALLTINEAS 6428
Query: 568 LKDAGVYECESKNKVGSQLRSLTLDVQ 594
+D+G Y CE+ N VG S L V+
Sbjct: 6429 AEDSGDYICEAHNGVGDASCSTALTVK 6455
Score = 73.2 bits (178), Expect = 7e-13
Identities = 106/439 (24%), Positives = 167/439 (38%), Gaps = 58/439 (13%)
Query: 170 RKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYIS-PKNTVI 228
R S SLE+ T V+ D G+ C+A + T+ ++S PK+
Sbjct: 3505 RSSKYISSLEILRTQVV-DCGEY-TCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTT 3562
Query: 229 SVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK------LDNGNLQHLSGNATLTLIAMR 282
V + K C+ G P E W K N + L L +
Sbjct: 3563 FVGKAAKF--------ICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLT 3614
Query: 283 MEDSGIYVCEGVNLIGKNRKEVELIVQAFPRD-PEIEMSGGLVNGSSVTVSCKVPSVYPL 341
++D G+Y C+ N G + + ELI+ P E+E +N V + C+V
Sbjct: 3615 IQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAIN-KKVHLECQVDE---- 3669
Query: 342 DRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPT--IEDTGKALVCQAKLHIDD 399
DR ++ + + + + D K + IP ++D+G VC A
Sbjct: 3670 DR-KVTVTWSK---DGQKLPPGKDYKICFEDKIATLEIPLAKLKDSG-TYVCTASN---- 3720
Query: 400 MEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLP 459
E + T+ V P V PS ++ G S + C +G P ++ W +
Sbjct: 3721 ---EAGSSSCSATVTVREPP-SFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKN-- 3774
Query: 460 NGELQP--------LSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDI 511
N EL ++ A L + K+EDSG Y CE +N G E++I+ P I
Sbjct: 3775 NKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFI 3834
Query: 512 KLTAFPSESVKEGDTVIISCT---CGNVPETWIILKKKAETGDTV----LKSIDGAYTIR 564
K T P++ V+ G ++ C G +W KK+ + KS+ I
Sbjct: 3835 K-TLEPADIVR-GTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSL-VCLEIF 3891
Query: 565 KAQLKDAGVYECESKNKVG 583
D G YEC N+VG
Sbjct: 3892 SFNSADVGEYECVVANEVG 3910
Score = 71.2 bits (173), Expect = 3e-12
Identities = 96/420 (22%), Positives = 162/420 (38%), Gaps = 46/420 (10%)
Query: 179 EVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQE 238
E TF V D+G+ C+A++++ ++ P+ + +K++ S K + I +
Sbjct: 4648 EYTFE-VQNDVGRSS-CKARINVLDLIIPPSFTKKLKKMD---SIKGSFIDLECIVAGSH 4702
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIG 298
S+ + + A E + DN A L + + DSG Y C N G
Sbjct: 4703 PISIQWFKDDQEISASEKYKFSFHDN--------TAFLEISQLEGTDSGTYTCSATNKAG 4754
Query: 299 KNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENI 358
N+ L V+ P E S V P R++++ L G T I
Sbjct: 4755 HNQCSGHLTVKEPPYFVEKPQS---------------QDVNPNTRVQLKALVGGTAPMTI 4799
Query: 359 EFLEDT-DMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV 417
++ +D ++ S +S+ T + A + +I + + S TL+V
Sbjct: 4800 KWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKE 4859
Query: 418 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSEN-------- 469
P+ SP +L G S C G P ++ W L E+ + ++
Sbjct: 4860 PPQFIKK-PSPVLVLRNGQSTTFECQITGTPKIRVSW--YLDGNEITAIQKHGISFIDGL 4916
Query: 470 ATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVII 529
AT + ++E+SG Y+CE N AG + +EL ++ P I+ P E VK D +
Sbjct: 4917 ATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIR-ELKPVEVVKYSDVELE 4975
Query: 530 SCTCGNVPETWIILKKKAETGDTVLKSIDGAYT-----IRKAQLKDAGVYECESKNKVGS 584
G P LK E + ++ + I K D G Y+C N+ GS
Sbjct: 4976 CEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGS 5035
Score = 70.9 bits (172), Expect = 4e-12
Identities = 128/595 (21%), Positives = 221/595 (37%), Gaps = 81/595 (13%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSY 93
A IG+ +L C G SW T++ S K+ + ++L +N V + Y
Sbjct: 7031 AVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEY 7090
Query: 94 LCTATCESRKLEKGIQVEIYSFPKDP-------EIHLSGPLEAGKPITVKCSVADVYPFD 146
C A + + I + P ++H + G P+ +C + P
Sbjct: 7091 SCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHET----LGFPVAFECRINGSEP-- 7144
Query: 147 RLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDS 206
L++ K L+K L+ + ++ T + T I C A + S
Sbjct: 7145 -LQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYN----CSASNPLGTASS 7199
Query: 207 VPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKL---- 262
+ + E+ + K S L G S T C G +I W+K
Sbjct: 7200 SAKLILSEHEVPPFFDLKPV------SVDLALGESGTFKCHVTGTAPIKITWAKDNREIR 7253
Query: 263 --DNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR-DPEIEM 319
N + + ATLT++ + D+G Y C N+ GK+ +L VQ PR ++E
Sbjct: 7254 PGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEP 7313
Query: 320 SGGLVNGSSVTVSCKV---PSVYPL---DRLEIELLKGETILENIEFLEDTDMKSLENKS 373
S + CK+ P + L D EI+ E+ + F++ + + N S
Sbjct: 7314 SRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQ----ESSKFRMSFVDSVAVLEMHNLS 7369
Query: 374 LEMTFIPTIE--DTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSI 431
+E + T E + + L + + K+ +TL
Sbjct: 7370 VEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETL------------------ 7411
Query: 432 LEEGSSVNMTCLSQGFPAPKILW---SRQLPNG-ELQPLSEN--ATLTLISTKMEDSGVY 485
+G+ V++ C QG P + W R+L +G + + +SEN ++ +++ D G Y
Sbjct: 7412 --KGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEY 7469
Query: 486 LCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTC-GNVPETWIILK 544
C+ N G + ++ P+ +K + S V G V + T G P + + K
Sbjct: 7470 QCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVV--GKEVQLQTTIEGAEPISVVWFK 7527
Query: 545 KKAE---TGDTVLKSID---GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
K E D + S + + +AG Y C+ KN G Q TL V
Sbjct: 7528 DKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSV 7582
Score = 70.9 bits (172), Expect = 4e-12
Identities = 128/592 (21%), Positives = 210/592 (35%), Gaps = 93/592 (15%)
Query: 40 GDSVSLTCSTTGCESPFFSWRTQIDSPLNG---KVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G +V+ T G SW + G V+ E + + L + V Y C
Sbjct: 7789 GTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCI 7848
Query: 97 ATCESRKLEKGIQVEI------------YSFPKDPEIHLSGPLEAGKPITV--KCSVADV 142
+ E+ K + I YS K + L G PI+V K + +V
Sbjct: 7849 VSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINV 7908
Query: 143 YPFDRLEIDLLKGDHLMK-SQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHI 201
P R I + +++ +EDA + + IE+ C A++ I
Sbjct: 7909 TPSQRCNITTTEKSAILEIPSSTVEDAGQ-----------YNCYIENASGKDSCSAQILI 7957
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK- 260
+ P V + P K+ G S ++ C G P + W K
Sbjct: 7958 -------------------LEPPYFVKQLEP-VKVSVGDSASLQCQLAGTPEIGVSWYKG 7997
Query: 261 ----KLDNGNLQHLSGN-ATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP 315
+ H N ATL + + DSG Y+C+ N +G+ L VQ P
Sbjct: 7998 DTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPP 8057
Query: 316 EIEMSGGLVN---GSSVTVSCKVPSVYPLDRLEIELLKGETILENIE--FLEDTDMKSL- 369
V G V C + P+ + K N++ FL++T ++
Sbjct: 8058 SFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIF 8117
Query: 370 -ENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSP 428
++SL + T + + A+L + + + P + +AP D V
Sbjct: 8118 KTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPP-------FFDIRLAPVDAVV---- 8166
Query: 429 SSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNG---ELQPLSENATLTLISTKMEDS 482
G S + C G K+ W SR++ +G ++ L +A LT++ DS
Sbjct: 8167 ------GESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDS 8220
Query: 483 GVYLCEGINQAGRSRKEVELIIQ---VTPKDIKLTAFPSESVKEGDTVIISCTCGNVPET 539
G Y C +N+ G+ +L I+ + P K + E + + G+ P T
Sbjct: 8221 GQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPIT 8280
Query: 540 WIILKKKAETGDT-----VLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQL 586
K E T K+ +RKA + DAG+Y C+ N GS L
Sbjct: 8281 VAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSAL 8332
Score = 70.5 bits (171), Expect = 5e-12
Identities = 123/582 (21%), Positives = 231/582 (39%), Gaps = 62/582 (10%)
Query: 40 GDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G+S C TG + +W +I N +T G T L + V G+ Y C
Sbjct: 6285 GESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQ 6344
Query: 97 ATCESRKLEKGIQVEIYSFPKD-PEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKG 155
AT + K Q+ + PK ++ S + G+ I ++C ++ +++ +
Sbjct: 6345 ATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGS---PEIKVSWFRN 6401
Query: 156 D-HLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAV 214
D L +S ++ + + + +L ED G +C A H D+ + V
Sbjct: 6402 DSELHESWKY----NMSFINSVALLTINEASAEDSGDY-ICEA--HNGVGDASCSTALTV 6454
Query: 215 KELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGNLQHLS 271
K V+ + V ++ +G V + C G P E+ W K++ N ++
Sbjct: 6455 KAPPVFTQKPSPVGAL-------KGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKIT 6507
Query: 272 G---NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSS 328
+ +L ++ + D G Y C+ N +G + + + PR + + G +
Sbjct: 6508 SKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDA 6567
Query: 329 VTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA 388
V + V P+ + ++ +GE I E+ E+T + ++N + P ++GK
Sbjct: 6568 VELRAIVEGFQPISVVWLKD-RGEVIRES----ENTRISFIDNIATLQLGSPEASNSGK- 6621
Query: 389 LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTCLSQGF 447
+CQ K + R+ + L V R ++ P + + G+ + C+ G
Sbjct: 6622 YICQIKN-------DAGMRECSAVLTVLEPAR---IIEKPEPMTVTTGNPFALECVVTGT 6671
Query: 448 PAPKILW---SRQLP---NGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVE 501
P W R+L + +++ A+L + +M D G+Y E N G+S V
Sbjct: 6672 PELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVS 6731
Query: 502 LIIQ---VTPKDIKLTAFPSESVKEGDTVIISC-TCGNVPET--WIILKKKAETGDTVLK 555
+ + V P I+ + G +V++ C G+ P + W + +G
Sbjct: 6732 VHVSDRIVPPSFIR--KLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQS 6789
Query: 556 SI-DGAYTIRKAQLK--DAGVYECESKNKVGSQLRSLTLDVQ 594
S + T+ + L+ D G+Y C + N GS S L VQ
Sbjct: 6790 SFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQ 6831
Score = 68.2 bits (165), Expect = 2e-11
Identities = 91/422 (21%), Positives = 149/422 (35%), Gaps = 61/422 (14%)
Query: 195 CRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAP 254
C A L + + P+ + +KE T G SV M C G P
Sbjct: 7669 CTASLQVSDRTVPPSFTRKLKE-----------------TNGLSGSSVVMECKVYGSPPI 7711
Query: 255 EIFW---SKKLDNGNLQHLS---GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIV 308
+ W ++ +G + LT+ + DSG Y C N+ G + L V
Sbjct: 7712 SVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTV 7771
Query: 309 QAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKS 368
+ P + ++ G++VT + V P + KG + L D S
Sbjct: 7772 REPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFS---VSWFKGSSELVP----GDRCNVS 7824
Query: 369 LENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSP 428
LE+ E+ C + E + T LY+ AP ++
Sbjct: 7825 LEDSVAELELFDVDTSQSGEYTCI-------VSNEAGKASCTTHLYIK-APAKFVKRLND 7876
Query: 429 SSILEEGSSVNMTCLSQGFPAPKILWSRQLPNG------ELQPLSENATLTLISTKMEDS 482
SI E+G + + G P + W + N + ++A L + S+ +ED+
Sbjct: 7877 YSI-EKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDA 7935
Query: 483 GVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWII 542
G Y C N +G+ +++I P +K V GD+ + C PE +
Sbjct: 7936 GQYNCYIENASGKDSCSAQILILEPPYFVK--QLEPVKVSVGDSASLQCQLAGTPEIGVS 7993
Query: 543 LKKKAETGDTVLKSID----------GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLD 592
K GDT L+ + + D+G Y C+++N VG S L
Sbjct: 7994 WYK----GDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLT 8049
Query: 593 VQ 594
VQ
Sbjct: 8050 VQ 8051
Score = 65.1 bits (157), Expect = 2e-10
Identities = 136/623 (21%), Positives = 225/623 (36%), Gaps = 106/623 (17%)
Query: 39 IGDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
+GDS SL C G SW T++ K+ +TL N V + Y+C
Sbjct: 7974 VGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYIC 8033
Query: 96 TATCESRKLEKG--IQVEIYSFPKDPEIHLSGPLE-AGKPITVKCSVADVYPFDRLEIDL 152
A ++ + V+ P L E G P+ C+++ P + +
Sbjct: 8034 KAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEP---ISVSW 8090
Query: 153 LKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLV----CRAKLHIDEMDS-- 206
K +K D +++T L+ T T I + L C A I S
Sbjct: 8091 YKDGKPLK--------DSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSA 8142
Query: 207 --VPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW---SKK 261
+ T + + ++P + V+ G S C G ++ W S++
Sbjct: 8143 RLILTEGKNPPFFDIRLAPVDAVV----------GESADFECHVTGTQPIKVSWAKDSRE 8192
Query: 262 LDNG---NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP--- 315
+ +G + +L +A LT++ + DSG Y C VN +GK+ +L ++ P
Sbjct: 8193 IRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFT 8252
Query: 316 -EIEMSGGLVNGSSVTVSCKVPSVYPL------DRLEIELLKGETILENIEFLEDTDMKS 368
+ + G+S + +V P+ + +EI+ T I F +T +
Sbjct: 8253 KRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQ----PTSNCEITFKNNTLVLQ 8308
Query: 369 LENKSLEMTFIPTIE---DTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVL 425
+ + + T + D G AL C + + I + + P Q T V
Sbjct: 8309 VRKAGMNDAGLYTCKVSNDAGSAL-CTSSIVIKEPKKPPVFDQHL-----------TPVT 8356
Query: 426 VSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQP--------LSENATLTLIST 477
VS EG V ++C QG +I W + E++P S A L L
Sbjct: 8357 VS------EGEYVQLSCHVQGSEPIRIQWLK--AGREIKPSDRCSFSFASGTAVLELRDV 8408
Query: 478 KMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTA---------FPSE----SVKEG 524
DSG Y+C+ N AG + ++ I+ P T F SE V E
Sbjct: 8409 AKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEK 8468
Query: 525 DTVIISCTCGNVP---ETWIILK-KKAETGDTVL---KSIDGAYTIRKAQLKDAGVYECE 577
T G P W K ++ G V K + IR D+G+Y C
Sbjct: 8469 TTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCV 8528
Query: 578 SKNKVGSQLRSLTLDVQGRENNK 600
+ N+ G ++ L V R+ +
Sbjct: 8529 AFNEHGEIESNVNLQVDERKKQE 8551
Score = 61.6 bits (148), Expect = 2e-09
Identities = 132/613 (21%), Positives = 234/613 (38%), Gaps = 83/613 (13%)
Query: 18 MFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNE 74
+F A +E S+ L + GD+ L C TG +W +I +++
Sbjct: 4293 LFVKEPATFVEKLEPSQLLKK-GDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFV 4351
Query: 75 GTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGK--P 132
+T+ L + V + Y+C A E+ V + P + P+E K
Sbjct: 4352 ESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEF--KPIEVLKEYD 4409
Query: 133 ITVKCSVADVYPFDRLEIDLLKGDHLMKS----QEFLEDADRKSLETKSLEVTFTPVIED 188
+ + VA PF EI K + +++S + F++D SL++ V D
Sbjct: 4410 VMLLAEVAGTPPF---EITWFKDNTILRSGRKYKTFIQD------HLVSLQI-LKFVAAD 4459
Query: 189 IGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS 248
G+ CR + S+ + R ++E P + + + ++ L+ GG+ +
Sbjct: 4460 AGE-YQCRVTNEVG--SSICSARVTLRE------PPSFIKKIESTSSLR-GGTAAFQATL 4509
Query: 249 EGLPAPEIFWSK------KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRK 302
+G + W K + DN + + A+L L + ++ G YVC+ N G R
Sbjct: 4510 KGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRC 4569
Query: 303 EVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEI----ELLKGE----TI 354
L V+ E +S + G T+ K + EL G ++
Sbjct: 4570 SALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISV 4629
Query: 355 LENIEFLEDTDMKSLENK-SLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTL 413
+ + L+ + S E K S E TF D G++ C+A++++ D+
Sbjct: 4630 TDTVSILK---IISTEKKDSGEYTF-EVQNDVGRS-SCKARINVLDL------------- 4671
Query: 414 YVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLS--- 467
+ P T L SI +GS +++ C+ G I W +++ E S
Sbjct: 4672 --IIPPSFTKKLKKMDSI--KGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHD 4727
Query: 468 ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTV 527
A L + + DSG Y C N+AG ++ L ++ P ++ S+ V V
Sbjct: 4728 NTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKP--QSQDVNPNTRV 4785
Query: 528 IISCTC-GNVPETWIILKKKAETGDTVLKSI-----DGAYTIRKAQLKDAGVYECESKNK 581
+ G P T K E +S+ + + A+ D+G Y C+ N
Sbjct: 4786 QLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSND 4845
Query: 582 VGSQLRSLTLDVQ 594
VG+ TL V+
Sbjct: 4846 VGTATSKATLFVK 4858
Score = 60.8 bits (146), Expect = 4e-09
Identities = 98/429 (22%), Positives = 159/429 (37%), Gaps = 86/429 (20%)
Query: 226 TVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGN---LQHLSGNATLTLI 279
T++ S K+ G + T+ C+ G P W K+L + N + + + L +I
Sbjct: 7587 TIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKII 7646
Query: 280 AMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP----EIEMSGGLVNGSSVTVSCKV 335
+ DSG+Y E N +GK+ L V P +++ + GL +GSSV + CKV
Sbjct: 7647 NVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGL-SGSSVVMECKV 7705
Query: 336 PSVYPLD-------------RLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTI 382
P+ R L T + LE++D S + T I T
Sbjct: 7706 YGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESD-------SGDYTCIAT- 7757
Query: 383 EDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTC 442
+ + C A L + + P P +L G++V T
Sbjct: 7758 -NMAGSDECSAPLTVRE-------------------PPSFVQKPDPMDVL-TGTNVTFTS 7796
Query: 443 LSQGFPAPKILW---SRQLPNGELQPLS---ENATLTLISTKMEDSGVYLCEGINQAGRS 496
+ +G P + W S +L G+ +S A L L SG Y C N+AG++
Sbjct: 7797 IVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKA 7856
Query: 497 RKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKK------AETG 550
L I+ K +K S+++G +I+ T P + KK ++
Sbjct: 7857 SCTTHLYIKAPAKFVK--RLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRC 7914
Query: 551 DTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVL 610
+ I + ++DAG Y C +N G KD S ++L+L
Sbjct: 7915 NITTTEKSAILEIPSSTVEDAGQYNCYIENASG----------------KDSCSAQILIL 7958
Query: 611 ---YFASSL 616
YF L
Sbjct: 7959 EPPYFVKQL 7967
Score = 60.1 bits (144), Expect = 6e-09
Identities = 86/412 (20%), Positives = 162/412 (39%), Gaps = 74/412 (17%)
Query: 203 EMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK-- 260
EM + P +++ ++ L+V + G TC + P W K
Sbjct: 3451 EMKAAPVIKRKIEPLEVAL-----------------GHLAKFTCEIQSAPNVRFQWFKAG 3493
Query: 261 ----KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIV-QAFP--- 312
+ D +++ ++L ++ ++ D G Y C+ N G L V +A+P
Sbjct: 3494 REIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTF 3553
Query: 313 --RDPEIEMSGGLVNG--SSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKS 368
R + G +VT + + +++ D + I + E+ +
Sbjct: 3554 LSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISD----AENKHILE 3609
Query: 369 LENKSLEMTFIPTIEDTGK--ALVCQAKLHIDDM-----EFEPKQRQSTQTLYVNVAPRD 421
L N +++ + + + + K A +CQA+L I D E EP Q + +++
Sbjct: 3610 LSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQ--- 3666
Query: 422 TTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPL---SENATLTLISTK 478
++E V +T G ++LP G+ + + ATL + K
Sbjct: 3667 ----------VDEDRKVTVTWSKDG---------QKLPPGKDYKICFEDKIATLEIPLAK 3707
Query: 479 MEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVP- 537
++DSG Y+C N+AG S + ++ P +K PS + G++ + C P
Sbjct: 3708 LKDSGTYVCTASNEAGSSSCSATVTVREPPSFVK-KVDPSYLMLPGESARLHCKLKGSPV 3766
Query: 538 --ETWIILKKKAETGDTV---LKSIDGAYTIRKAQLKDAGVYECESKNKVGS 584
TW K+ +TV + + I +++D+G Y CE+ N VGS
Sbjct: 3767 IQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGS 3818
Score = 58.9 bits (141), Expect = 1e-08
Identities = 129/604 (21%), Positives = 224/604 (37%), Gaps = 101/604 (16%)
Query: 40 GDSVSLTCSTTGCESPFFSWRTQIDSPL----NGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
G+ L S G + F W + + + N ++T +TL N Y+C
Sbjct: 5624 GEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYIC 5683
Query: 96 TATCESRKLEKGIQVEIYSFPKDPEIHL--SGPLEA--GKPITVKCSVADVYPFDRLEID 151
+ E + + +P + + +GP+ G+ T++C VA L ++
Sbjct: 5684 QIKNDGGMRENMATLMVL----EPAVIVEKAGPMTVTVGETCTLECKVAGT---PELSVE 5736
Query: 152 LLKGDHLMKSQE---FLEDADRKSLETKSLEV----TFT-PVIEDIGKVLVCRAKLHIDE 203
K L+ S + F SL S+E T+T V ++GK C A + + +
Sbjct: 5737 WYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSS-CTAVVDVSD 5795
Query: 204 MDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW----S 259
P+ + +K + G S + C G + W +
Sbjct: 5796 RAVPPSFTRRLKNTGGVL-----------------GASCILECKVAGSSPISVAWFHEKT 5838
Query: 260 KKLDNGNLQHLSGN--ATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQ---AFPRD 314
K + Q + TL L ++ D G Y C N+ G + L VQ +F ++
Sbjct: 5839 KIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKE 5898
Query: 315 PE-IEMSGGLVNGSSVTVSCKVPSVYPLD----RLEIELLKGETILENIEFLEDTDMKSL 369
PE +E+ + G +VT + + P R EL+KG+ NI F EDT + L
Sbjct: 5899 PEPLEV----LPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRC--NIYF-EDT-VAEL 5950
Query: 370 ENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPS 429
E +++++ Q+ + + Q T L+V P +S
Sbjct: 5951 ELFNIDIS--------------QSGEYTCVVSNNAGQASCTTRLFVK-EPAAFLKRLSDH 5995
Query: 430 SILEEGSSVNMTCLSQGFPAPKILWSRQLPN------GELQPLSENATLTLISTKMEDSG 483
S+ E G S+ + G + W + N + + L ++++ D+G
Sbjct: 5996 SV-EPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAG 6054
Query: 484 VYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIIL 543
Y CE N+AGR L+ + P P E+ GD+V + C PE +
Sbjct: 6055 QYSCEIENEAGRDVCGA-LVSTLEPPYFVTELEPLEAAV-GDSVSLQCQVAGTPEITVSW 6112
Query: 544 KKKAETGDTVLKSIDGAYT----------IRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
K GDT L+ T K + D+G Y C+++N +G+ +
Sbjct: 6113 YK----GDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRI 6168
Query: 594 QGRE 597
Q R+
Sbjct: 6169 QERQ 6172
Score = 58.5 bits (140), Expect = 2e-08
Identities = 128/609 (21%), Positives = 211/609 (34%), Gaps = 109/609 (17%)
Query: 39 IGDSVSLTCSTTGCESPFFSWRTQ----IDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYL 94
IGD+V L G + W I N +++ +TL + N Y+
Sbjct: 6564 IGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYI 6623
Query: 95 CTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLK 154
C ++ E + + + E + G P ++C V
Sbjct: 6624 CQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPEL--------- 6674
Query: 155 GDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAV 214
S ++ +D S ++K +TF I KV K+ EM V
Sbjct: 6675 ------SAKWFKDGRELSADSKH-HITF------INKV--ASLKIPCAEMSDKGLYSFEV 6719
Query: 215 KELQVYISPKNTVISVNPSTKLQE--------------GGSVTMTCSSEGLPAPEIFWSK 260
K + N +SV+ S ++ G SV + C G + W
Sbjct: 6720 KNS---VGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGW-- 6774
Query: 261 KLDNGNLQHLSGN----------ATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQA 310
+GN + +SG TL L + D+GIY C N+ G + L VQ
Sbjct: 6775 -FQDGN-EIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQE 6832
Query: 311 FPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLD----RLEIELLKGETILENIEFLED--T 364
P + S ++ G S+T + + P + EL+ GE+ NI LED T
Sbjct: 6833 PPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESC--NIS-LEDFVT 6889
Query: 365 DMKSLENKSLEMTFIPTI--EDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDT 422
+++ E + LE + D G A + T ++ V T
Sbjct: 6890 ELELFEVQPLESGDYSCLVTNDAGSA---------------------SCTTHLFVKEPAT 6928
Query: 423 TVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR------QLPNGELQPLSENATLTLIS 476
V +E GS + + G P + W + Q + ++ L ++
Sbjct: 6929 FVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILE 6988
Query: 477 TKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKE--GDTVIISCTCG 534
+ +ED Y C N+AG+ E + + P I+ P E V+ G+ + C
Sbjct: 6989 STIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIE----PLEHVEAVIGEPATLQCKVD 7044
Query: 535 NVPETWIILKKK------AETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRS 588
PE I K+ A K+ + I K D G Y C++ N VG+ S
Sbjct: 7045 GTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASS 7104
Query: 589 LTLDVQGRE 597
L ++ R+
Sbjct: 7105 AVLVIKARK 7113
Score = 58.5 bits (140), Expect = 2e-08
Identities = 61/300 (20%), Positives = 120/300 (40%), Gaps = 23/300 (7%)
Query: 221 ISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK------LDNGNLQHLSGNA 274
+S IS S + EG +V TC G P+PEI W K N ++
Sbjct: 33130 LSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVY 33189
Query: 275 TLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCK 334
+L + + DSG Y + N G+ L+V +P E+ +S+ S
Sbjct: 33190 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFS 33249
Query: 335 VPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAK 394
SV ++ K E + + M ++ S+ + +++++ + +
Sbjct: 33250 SQSV------QMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSF 33303
Query: 395 LHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTCLSQGFPAPKIL 453
+ I +M + +++ L + + PS I ++EG + + C G P P++
Sbjct: 33304 MGISNM--TQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVT 33361
Query: 454 WS---RQLPNGE-----LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 505
WS R++ + E ++ + TL ++ + +D G+Y N+ G V + I+
Sbjct: 33362 WSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421
Score = 57.8 bits (138), Expect = 3e-08
Identities = 108/451 (23%), Positives = 179/451 (39%), Gaps = 72/451 (15%)
Query: 175 TKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPST 234
T SLE+ + D G CRA + DS + V+E +++ S
Sbjct: 4167 TASLEIIRVDM-NDAGN-FTCRATNSVGSKDSSGAL--IVQEPPSFVTKPG-------SK 4215
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGNLQHLSGNA---TLTLIAMRMEDSGI 288
+ G +V + + +G I W +K+L +G +++ A +L L ++ DSG
Sbjct: 4216 DVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGT 4275
Query: 289 YVCEGVNLIGKNRKEVELIVQAFPRDP-----EIEMSGGLVNGSSVTVSCKVPSVYPL-- 341
Y C+ N+ G VE F ++P ++E S L G + ++CKV P+
Sbjct: 4276 YTCKVSNVAGG----VECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKI 4331
Query: 342 -----DRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLH 396
DR EI+ E+ + F+E T + L + IED+G+ + C+A
Sbjct: 4332 TWFANDR-EIK----ESSKHRMSFVESTAVLRLTDVG--------IEDSGEYM-CEA--- 4374
Query: 397 IDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR 456
+ E + + V +P T P +L+E V + G P +I W +
Sbjct: 4375 ----QNEAGSDHCSSIVIVKESPYFTKEF-KPIEVLKE-YDVMLLAEVAGTPPFEITWFK 4428
Query: 457 Q---LPNGELQPL---SENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKD 510
L +G +L ++ D+G Y C N+ G S + ++ P
Sbjct: 4429 DNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSF 4488
Query: 511 IKLTAFPSESVKEGDTVIISCTC-GNVPETWIILKKKAETGD------TVLKSIDGAYTI 563
IK S S G T T G++P T LK E + T ++ Y +
Sbjct: 4489 IK--KIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLY-L 4545
Query: 564 RKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
++K G Y C++KN G Q S L V+
Sbjct: 4546 SGIEVKHDGKYVCQAKNDAGIQRCSALLSVK 4576
Score = 57.4 bits (137), Expect = 4e-08
Identities = 97/454 (21%), Positives = 171/454 (37%), Gaps = 61/454 (13%)
Query: 151 DLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTV 210
+L+ G ++E LE + L S T+T + ++ + C A L + E
Sbjct: 4245 ELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKE------- 4297
Query: 211 RQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW------SKKLDN 264
P V + PS L++G + + C G P +I W K+
Sbjct: 4298 ------------PATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSK 4345
Query: 265 GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLV 324
+ + A L L + +EDSG Y+CE N G + +IV+ P + ++
Sbjct: 4346 HRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVL 4405
Query: 325 NGSSVTVSCKVPSVYPLDRLEIELLKGETILEN----IEFLED--TDMKSLENKSLEM-T 377
V + +V P EI K TIL + F++D ++ L+ + +
Sbjct: 4406 KEYDVMLLAEVAGTPP---FEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGE 4462
Query: 378 FIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSS 437
+ + + + +C A++ + + K+ +ST +L A T L+
Sbjct: 4463 YQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSLRGGTAAFQAT--------LKGSLP 4514
Query: 438 VNMTCLSQGFPAPKILWSRQLPNGELQPLSEN--ATLTLISTKMEDSGVYLCEGINQAGR 495
+ +T L + ++ EN A+L L +++ G Y+C+ N AG
Sbjct: 4515 ITVTWLKDS--------DEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGI 4566
Query: 496 SRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDT 552
R L ++ P I A S V +GD + E W ++ G
Sbjct: 4567 QRCSALLSVK-EPATITEEAV-SIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSK 4624
Query: 553 VLKSIDGAYTIRK---AQLKDAGVYECESKNKVG 583
S+ +I K + KD+G Y E +N VG
Sbjct: 4625 YKISVTDTVSILKIISTEKKDSGEYTFEVQNDVG 4658
Score = 56.6 bits (135), Expect = 7e-08
Identities = 87/398 (21%), Positives = 155/398 (38%), Gaps = 54/398 (13%)
Query: 226 TVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK---KLDNGNLQHLSGNAT---LTLI 279
T+ S + +G T+ G W K +L G+ +S T L +I
Sbjct: 4580 TITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKII 4639
Query: 280 AMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMS---GGLVNGSSVTVSCKVP 336
+ +DSG Y E N +G++ + + V P + GS + + C V
Sbjct: 4640 STEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVA 4699
Query: 337 SVYPLD----RLEIELLKGE----TILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA 388
+P+ + + E+ E + +N FLE + ++ ++ + T T KA
Sbjct: 4700 GSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTY------TCSATNKA 4753
Query: 389 LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP 448
Q H+ E P + Q+ VN R V + L G
Sbjct: 4754 GHNQCSGHLTVKE-PPYFVEKPQSQDVNPNTR-----------------VQLKALVGGTA 4795
Query: 449 APKILW---SRQLPNGELQPLSENATLT---LISTKMEDSGVYLCEGINQAGRSRKEVEL 502
I W +++L +G + + ++ T T L + K DSG Y+C+ N G + + L
Sbjct: 4796 PMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATL 4855
Query: 503 IIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKS----ID 558
++ P+ IK + P ++ G + C P+ + + K ID
Sbjct: 4856 FVKEPPQFIKKPS-PVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFID 4914
Query: 559 GAYT--IRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
G T I A+++++G Y CE++N G+ S+ L V+
Sbjct: 4915 GLATFQISGARVENSGTYVCEARNDAGTASCSIELKVK 4952
Score = 55.5 bits (132), Expect = 2e-07
Identities = 90/410 (21%), Positives = 141/410 (34%), Gaps = 71/410 (17%)
Query: 223 PKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLS--------GNA 274
P + + PS +++ C G P ++ W K D +Q S A
Sbjct: 7304 PPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYK--DETEIQESSKFRMSFVDSVA 7361
Query: 275 TLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCK 334
L + + +EDSG Y CE N G L V+ P + + G+ V + C+
Sbjct: 7362 VLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECE 7421
Query: 335 VPSVYPL------DRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA 388
+ P D+ E+ K I+ FL + +++ + D G
Sbjct: 7422 LQGTPPFHVSWYKDKRELRSGKKYKIMSE-NFLTSIHILNVDAADIGEYQCKATNDVGSD 7480
Query: 389 LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP 448
++ + PR L S+++ G V + +G
Sbjct: 7481 TC-------------------VGSIALKAPPRFVKKLSDISTVV--GKEVQLQTTIEGAE 7519
Query: 449 APKILWSRQLPNGELQPLSEN---------ATLTLISTKMEDSGVYLCEGINQAGRSRKE 499
++W + GE+ S+N ATL + ++G Y C+ N AG
Sbjct: 7520 PISVVWFKD--KGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECF 7577
Query: 500 VEL------IIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE--TWIILKKKAETGD 551
L I P+ IK+T GDT + CT PE T K T D
Sbjct: 7578 ATLSVLEPATIVEKPESIKVTT--------GDTCTLECTVAGTPELSTKWFKDGKELTSD 7629
Query: 552 TVLK-----SIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGR 596
K + G I A D+GVY E +N VG + +L V R
Sbjct: 7630 NKYKISFFNKVSGLKIINVAP-SDSGVYSFEVQNPVGKDSCTASLQVSDR 7678
Score = 55.5 bits (132), Expect = 2e-07
Identities = 120/593 (20%), Positives = 212/593 (35%), Gaps = 79/593 (13%)
Query: 40 GDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G SV + C G SW +I S + T T LT+N + + Y C
Sbjct: 7696 GSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCI 7755
Query: 97 ATCESRKLEKGIQVEIY---SFPKDPEIHLSGPLEA--GKPITVKCSVADVYPFD----R 147
AT + E + + SF + P+ P++ G +T V PF +
Sbjct: 7756 ATNMAGSDECSAPLTVREPPSFVQKPD-----PMDVLTGTNVTFTSIVKGTPPFSVSWFK 7810
Query: 148 LEIDLLKGDHLMKS-QEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDS 206
+L+ GD S ++ + + + ++T S +T ++ + C L+I
Sbjct: 7811 GSSELVPGDRCNVSLEDSVAELELFDVDT-SQSGEYTCIVSNEAGKASCTTHLYIK---- 7865
Query: 207 VPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNG- 265
+ VK L Y +++G + + + G P + W K N
Sbjct: 7866 --APAKFVKRLNDY--------------SIEKGKPLILEGTFTGTPPISVTWKKNGINVT 7909
Query: 266 -----NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMS 320
N+ +A L + + +ED+G Y C N GK+ ++++ P +
Sbjct: 7910 PSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEP 7969
Query: 321 GGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIP 380
+ G S ++ C++ + + KG+T L T N + F
Sbjct: 7970 VKVSVGDSASLQCQLAGT---PEIGVSWYKGDTKLRPTT----TYKMHFRNNVATLVFNQ 8022
Query: 381 T-IEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAP--RDTTVLVSPSSILEEGSS 437
I D+G+ +C+A+ + ++ Q L + + RD V G
Sbjct: 8023 VDINDSGE-YICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETV--------GLP 8073
Query: 438 VNMTCLSQGFPAPKILWSRQ------LPNGELQPLSENATLTLISTKMEDSGVYLCEGIN 491
V C G + W + PN + L ATL + T +G Y C N
Sbjct: 8074 VVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATN 8133
Query: 492 QAGRSRKEVELIIQV--TPKDIKLTAFPSESVKEGDTVIISC-TCGNVP--ETWIILKKK 546
G + LI+ P + P ++V G++ C G P +W ++
Sbjct: 8134 PIGSASSSARLILTEGKNPPFFDIRLAPVDAVV-GESADFECHVTGTQPIKVSWAKDSRE 8192
Query: 547 AETGDTVLKSI---DGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGR 596
+G S T+ K D+G Y C + N+VG + L+++ R
Sbjct: 8193 IRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKER 8245
Score = 55.1 bits (131), Expect = 2e-07
Identities = 115/564 (20%), Positives = 211/564 (37%), Gaps = 96/564 (17%)
Query: 63 IDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSF--PKDP- 119
+D N ++ + +TL + V G+ Y C A K E G++ Y+F ++P
Sbjct: 5088 LDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQA-----KNESGVE-RCYAFLLVQEPA 5141
Query: 120 ---EIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLK-GDHLMKSQEFLEDAD------ 169
E S + P+T++C VA L++ LK G ++ S+ F +
Sbjct: 5142 QIVEKAKSVDVTEKDPMTLECVVAGT---PELKVKWLKDGKQIVPSRYFSMSFENNVASF 5198
Query: 170 --RKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTV 227
+ ++ S + TF V D G C A L + + + P+ + + ++ +
Sbjct: 5199 RIQSVMKQDSGQYTFK-VENDFGSSS-CDAYLRVLDQNIPPSFTKKLTKMDKVL------ 5250
Query: 228 ISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGNLQHL---SGNATLTLIAM 281
G S+ M C G W K++ L + +L + +
Sbjct: 5251 -----------GSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNL 5299
Query: 282 RMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPL 341
+ED+ Y C+ N+ G + L V+ P S V P
Sbjct: 5300 ELEDTANYTCKVSNVAGDDACSGILTVKEPP---------------SFLVKPGRQQAIPD 5344
Query: 342 DRLEIE-LLKGETILENIEFLEDTDMKSLENKSLEM---TFIPTIEDTGKALVCQAKLHI 397
+E + +LKG + F +D ++ S + + T + + Q H+
Sbjct: 5345 STVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHV 5404
Query: 398 DDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ 457
+ S T+ + P + S I++ G S + C G P +++W R
Sbjct: 5405 TN----DVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFR- 5459
Query: 458 LPNGELQPLSENATLTLIST---------KMEDSGVYLCEGINQAGRSRKEVELIIQVTP 508
N P S+ +T I + EDSG ++CE N AG + ++I++ P
Sbjct: 5460 --NEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPP 5517
Query: 509 KDIKLTAFPS--ESVKEGDTVIISCTCGNVPETWIILKK------KAETGDTVLKSIDGA 560
++FP E++K + V + C P ++ K ++ K+ +
Sbjct: 5518 ---VFSSFPPIVETLKNAE-VSLECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTS 5573
Query: 561 YTIRKAQLKDAGVYECESKNKVGS 584
I D G Y C+++N+VGS
Sbjct: 5574 IHILNVDTSDIGEYHCKAQNEVGS 5597
Score = 54.7 bits (130), Expect = 3e-07
Identities = 123/590 (20%), Positives = 217/590 (36%), Gaps = 83/590 (14%)
Query: 32 ESRYLAQIGDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFG 88
E+ +A+ G+S+ L C +G SW +++ ++ + + LT+N S
Sbjct: 6371 EASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAE 6430
Query: 89 NEHSYLCTA-------TCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA--GKPITVKCSV 139
+ Y+C A +C + K V F + P P+ A G + ++C +
Sbjct: 6431 DSGDYICEAHNGVGDASCSTALTVKAPPV----FTQKPS-----PVGALKGSDVILQCEI 6481
Query: 140 ADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKL 199
+ PF+ + + K K + SL +LE + D+G+ C+A
Sbjct: 6482 SGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEAS------DVGEYH-CKATN 6534
Query: 200 HIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWS 259
+ T +VK + P V ++ ++ L G +V + EG + W
Sbjct: 6535 EVGS----DTCSCSVK----FKEPPRFVKKLSDTSTLI-GDAVELRAIVEGFQPISVVWL 6585
Query: 260 K-------KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFP 312
K + +N + + ATL L + +SG Y+C+ N G L V
Sbjct: 6586 KDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPA 6645
Query: 313 RDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENK 372
R E + G+ + C V L + ++ +D S ++K
Sbjct: 6646 RIIEKPEPMTVTTGNPFALECVVTGTPEL---------------SAKWFKDGRELSADSK 6690
Query: 373 SLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSIL 432
+TFI + + + E + +S T+ V+V+ R +V PS I
Sbjct: 6691 H-HITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDR----IVPPSFIR 6745
Query: 433 EE-------GSSVNMTCLSQGFPAPKILW---SRQLPNGEL--QPLSENA-TLTLISTKM 479
+ G+SV + C G + W ++ +G SEN TL L +
Sbjct: 6746 KLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEP 6805
Query: 480 EDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVP-- 537
D+G+Y C N AG L +Q P + T E + S G P
Sbjct: 6806 SDTGIYTCVAANVAGSDECSAVLTVQ-EPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFK 6864
Query: 538 ETWIILKKKAETGDTVLKSIDGAYT---IRKAQLKDAGVYECESKNKVGS 584
W ++ G++ S++ T + + Q ++G Y C N GS
Sbjct: 6865 VKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGS 6914
Score = 52.4 bits (124), Expect = 1e-06
Identities = 54/213 (25%), Positives = 80/213 (37%), Gaps = 14/213 (6%)
Query: 410 TQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ------LPNGEL 463
T TL V A T + S G + C G P + +W + PN +
Sbjct: 3540 TATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRI 3599
Query: 464 QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKE 523
L L + ++D GVY C+ N+ G + ELII P IK ++ +
Sbjct: 3600 SDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINK 3659
Query: 524 GDTVIISCTCG---NVPETWIILKKKAETGDTVLKSID---GAYTIRKAQLKDAGVYECE 577
V + C V TW +K G + I A+LKD+G Y C
Sbjct: 3660 --KVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCT 3717
Query: 578 SKNKVGSQLRSLTLDVQGRENNKDYFSPELLVL 610
+ N+ GS S T+ V+ + P L+L
Sbjct: 3718 ASNEAGSSSCSATVTVREPPSFVKKVDPSYLML 3750
Score = 52.4 bits (124), Expect = 1e-06
Identities = 124/591 (20%), Positives = 219/591 (37%), Gaps = 87/591 (14%)
Query: 32 ESRYLAQIGDSVSLTCSTTGCESPFFSW-RTQIDSPLNGK--VTNEGTTSTLTMNPVSFG 88
E+ + + GDS L C G W R + + P + K +T + + + MN +S
Sbjct: 5430 EASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTE 5489
Query: 89 NEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGP--LEAGK--PITVKCSVADVYP 144
+ ++C A + +V + K+P + S P +E K ++++C ++ P
Sbjct: 5490 DSGDFICEAQNPAGSTSCSTKVIV----KEPPVFSSFPPIVETLKNAEVSLECELSGTPP 5545
Query: 145 FDRLEIDLLKGDHLMKSQEFLEDADRK---SLETKSLEVTFTPVIEDIGKVLVCRAKLHI 201
F E+ K ++S + + A + S+ +++ + DIG+ C+A+ +
Sbjct: 5546 F---EVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTS------DIGEYH-CKAQNEV 5595
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK 261
V TV+ +KE ++S N++ V G + S EG + W K+
Sbjct: 5596 GSDTCVCTVK--LKEPPRFVSKLNSLTVV-------AGEPAELQASIEGAQPIFVQWLKE 5646
Query: 262 LD-------NGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRD 314
+ N + + ATL ++G Y+C+ N G L+V +
Sbjct: 5647 KEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVL----E 5702
Query: 315 PEI--EMSGGLVN--GSSVTVSCKVPSVYPLDRLEIELLKGETILENIE---FLEDTDMK 367
P + E +G + G + T+ CKV L +E K +L + + F +
Sbjct: 5703 PAVIVEKAGPMTVTVGETCTLECKVAGT---PELSVEWYKDGKLLTSSQKHKFSFYNKIS 5759
Query: 368 SLENKSLEM----TFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTT 423
SL S+E T+ +++ C A + + D V P T
Sbjct: 5760 SLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRA---------------VPPSFTR 5804
Query: 424 VLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ----LPNGELQP-LSENA-TLTLIST 477
L + +L G+S + C G + W + + + Q S+N TL L S
Sbjct: 5805 RLKNTGGVL--GASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSL 5862
Query: 478 KMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVP 537
D G Y C N AG L +Q P +K P E + + S G P
Sbjct: 5863 DSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVK-EPEPLEVLPGKNVTFTSVIRGTPP 5921
Query: 538 --ETWIILKKKAETGD---TVLKSIDGAYTIRKAQLKDAGVYECESKNKVG 583
W ++ GD + + + +G Y C N G
Sbjct: 5922 FKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAG 5972
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/187 (24%), Positives = 77/187 (41%), Gaps = 21/187 (11%)
Query: 429 SSILEEGSSVNMTCLSQGFPAPKILWSRQ--------LPNGELQPLSENATLTLISTKME 480
S ++ EGS+ GFP P++ W R LP ++ A LT+ +
Sbjct: 14 SVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKA 73
Query: 481 DSGVYLCEGINQAGRSRKEVELIIQV-TPKDIKLTAFPSESVKEGDTVIISCTCGNVPET 539
+SG Y + N +G++ EL+++ T + S +V++G V + +P
Sbjct: 74 NSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTP 133
Query: 540 WIILKKKAETGDTVLKSID---------GAYTIRKAQLKDAGVYECESKNKVGSQLRSLT 590
+ K G + S+D + I +A +D+G Y + N VG +
Sbjct: 134 VV---KFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAE 190
Query: 591 LDVQGRE 597
L VQG E
Sbjct: 191 LLVQGEE 197
Score = 51.6 bits (122), Expect = 2e-06
Identities = 118/587 (20%), Positives = 217/587 (36%), Gaps = 94/587 (16%)
Query: 40 GDSVSLTCSTTGCESPFFSWR---TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G S + C TG SW +I + ++ +T ++ N +Y+C
Sbjct: 4876 GQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCE 4935
Query: 97 ATCESRKLEKGIQVEIYSFPKDPEIHLSG--PLEAGK--PITVKCSVADVYPFDRLEIDL 152
A ++ I++++ K+P + P+E K + ++C V PF E+
Sbjct: 4936 ARNDAGTASCSIELKV----KEPPTFIRELKPVEVVKYSDVELECEVTGTPPF---EVTW 4988
Query: 153 LKGDHLMKSQEFLEDADRKSLETKSLEVT---------FTPVIEDIGKVLVCRAKLHIDE 203
LK + ++S + DR S+ +L +T + ++ + G C ++ + E
Sbjct: 4989 LKNNREIRSSKKYTLTDRVSVF--NLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKE 5046
Query: 204 MDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK--- 260
S +K+++ N +T L+ S T + G P I W K
Sbjct: 5047 PPSF------IKKIE------------NTTTVLKS--SATFQSTVAGSPPISITWLKDDQ 5086
Query: 261 ---KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEI 317
+ DN + + ATL + ++ SG Y C+ N G R L+VQ + E
Sbjct: 5087 ILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEK 5146
Query: 318 EMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLK-GETILENIEFLEDTD--------MKS 368
S + +T+ C V L+++ LK G+ I+ + F +
Sbjct: 5147 AKSVDVTEKDPMTLECVVAGT---PELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSV 5203
Query: 369 LENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSP 428
++ S + TF +E+ + C A L + D N+ P T L
Sbjct: 5204 MKQDSGQYTF--KVENDFGSSSCDAYLRVLDQ---------------NIPPSFTKKLTKM 5246
Query: 429 SSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPL---SENATLTLISTKMEDS 482
+L GSS++M C G W +++ L + +L + + ++ED+
Sbjct: 5247 DKVL--GSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDT 5304
Query: 483 GVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVP--ETW 540
Y C+ N AG L ++ P + +++ + + G P W
Sbjct: 5305 ANYTCKVSNVAGDDACSGILTVK-EPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKW 5363
Query: 541 IILKKKAETGDTVLKSIDGAYTIRKAQLKDA---GVYECESKNKVGS 584
+ +G ++G+ + DA G Y C N VGS
Sbjct: 5364 FKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGS 5410
Score = 49.7 bits (117), Expect = 8e-06
Identities = 67/302 (22%), Positives = 113/302 (37%), Gaps = 60/302 (19%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFWSKK---LDNGNLQHLS-----GNATLTLIAMRMEDS 286
KL EGGSV C G P P ++W K L G +S G L + +D+
Sbjct: 1092 KLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDA 1151
Query: 287 GIYVCEGVNLIGKNRKEVELI--------------------VQAFPRDPEI-EMSGGLVN 325
G Y N G+ L+ V AF ++P++ E + G V
Sbjct: 1152 GEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVY 1211
Query: 326 GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEF----LEDTDMKSLENKSLEMTFIPT 381
S + ++ + + T +E+ EF E+ +K +E + ++ T
Sbjct: 1212 -SEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEEL 1270
Query: 382 IEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMT 441
+E+ G + K+ +D E E + + ++ +L EG V
Sbjct: 1271 LEEDG-----EEKMAVDISESEAVESGFDSRI------KNYRIL--------EGMGVTFH 1311
Query: 442 CLSQGFPAPKILW---SRQLPNGELQPL----SENATLTLISTKMEDSGVYLCEGINQAG 494
C G+P PKI W +++ +GE + A+L + ED G+Y N G
Sbjct: 1312 CKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKG 1371
Query: 495 RS 496
+
Sbjct: 1372 NA 1373
Score = 49.3 bits (116), Expect = 1e-05
Identities = 89/427 (20%), Positives = 167/427 (39%), Gaps = 50/427 (11%)
Query: 201 IDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW-- 258
+ ++ PT + V+ L V PK T ++K E +T S L A E+ W
Sbjct: 32696 VSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASK--EIAKLTCVVESSVLRAKEVTWYK 32753
Query: 259 -SKKL-DNGNLQ-HLSGNAT--LTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAF-- 311
KKL +NG+ Q H S + T L + + D G YVCE G ++ ++ + QAF
Sbjct: 32754 DGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKS 32813
Query: 312 -----PRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDM 366
+ E + S S+VT + + P+ + + T L++ D+
Sbjct: 32814 IHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIV----TGLQDTTVSSDSVA 32869
Query: 367 KSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDME----FEPKQRQSTQTLYVNVAPRDT 422
K + E GKA+ K + + + E + ++ + +++
Sbjct: 32870 KFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNS 32929
Query: 423 TVLVSPSSIL-------EEGSSVNMTCLSQGFPAPKILWSRQLPNGELQ----PLSENAT 471
VS S L E V+ S+ P K + ++ L+ +SE +
Sbjct: 32930 AGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKS 32989
Query: 472 LTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK----------DIKLTAFPSE-S 520
++ K E S V + E + ++ + E ++ + K ++ AF ++ S
Sbjct: 32990 QEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMS 33049
Query: 521 VKEGDTVIISCT-CGNVPETWIILKKKAETGDTVLKSIDGA---YTIRKAQLKDAGVYEC 576
+ EG +++ G W++ + + + G+ TI++A +D G+ C
Sbjct: 33050 INEGQRLVLKANIAGATDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTC 33109
Query: 577 ESKNKVG 583
SK K G
Sbjct: 33110 ISKTKEG 33116
Score = 48.5 bits (114), Expect = 2e-05
Identities = 107/553 (19%), Positives = 204/553 (36%), Gaps = 68/553 (12%)
Query: 70 KVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKD-PEIHLSGPLE 128
K+ E +TL + + +Y+CTA+ E+ V + P ++ S +
Sbjct: 3691 KICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLML 3750
Query: 129 AGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIED 188
G+ + C LKG +++ F + + T + + I D
Sbjct: 3751 PGESARLHCK--------------LKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILD 3796
Query: 189 IGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS 248
I V V + + ++V V ++ I + I + G + + C
Sbjct: 3797 ITDVKVEDSGSY--SCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEV 3854
Query: 249 EGLPAPEIFW---SKKLDNGNLQHLSGNATLT---LIAMRMEDSGIYVCEGVNLIGKNRK 302
G EI W K++ + L +L + + D G Y C N +GK
Sbjct: 3855 SGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCGC 3914
Query: 303 EVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLE 362
+++ P + + G +VT+ V P+ + +KG+ ++ E
Sbjct: 3915 MATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPIS---VTWMKGQEVIR-----E 3966
Query: 363 DTDMKSLENKSLEMTFIPTIEDT-GKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRD 421
D +K + + + IP ++ + G C A+ +QT + ++
Sbjct: 3967 DGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAE-----------NEAGSQTSVGELIVKE 4015
Query: 422 TTVLVSPSSILE--EGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLSEN---ATLT 473
++ + +++ G + G P K W R L + +S A L
Sbjct: 4016 PAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLK 4075
Query: 474 LISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTC 533
S ++ DSG Y E N+ G S E T D + F ++ ++ D+V+ + TC
Sbjct: 4076 FYSAELHDSGQYTFEISNEVGSSSCETTF----TVLDRDIAPFFTKPLRNVDSVV-NGTC 4130
Query: 534 -------GNVPE--TWIILKKKAETGDTV-LKSIDGAYTIR--KAQLKDAGVYECESKNK 581
G++P +W K+ D + ++G ++ + + DAG + C + N
Sbjct: 4131 RLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNS 4190
Query: 582 VGSQLRSLTLDVQ 594
VGS+ S L VQ
Sbjct: 4191 VGSKDSSGALIVQ 4203
Score = 48.1 bits (113), Expect = 2e-05
Identities = 90/423 (21%), Positives = 168/423 (39%), Gaps = 81/423 (19%)
Query: 194 VCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPA 253
+C+A+L I + +KEL+ S N V+ ++ E VT+T S +G
Sbjct: 3633 ICQAELIIIDKPHF------IKELEPVQSAINK--KVHLECQVDEDRKVTVTWSKDGQKL 3684
Query: 254 P-----EIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIV 308
P +I + K+ ATL + +++DSG YVC N G + + V
Sbjct: 3685 PPGKDYKICFEDKI-----------ATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTV 3733
Query: 309 QAFPR-DPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMK 367
+ P +++ S ++ G S + CK LKG +++ F + ++
Sbjct: 3734 REPPSFVKKVDPSYLMLPGESARLHCK--------------LKGSPVIQVTWFKNNKELS 3779
Query: 368 SLENKSLEMTFIPT----------IEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV 417
E+ ++ M F+ + +ED+G + C+A ++D+ + S T V
Sbjct: 3780 --ESNTVRMYFVNSEAILDITDVKVEDSG-SYSCEA---VNDVGSD-----SCSTEIVIK 3828
Query: 418 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLSENATLT- 473
P + P+ I+ G++ + C G +I W +Q+ + + L +L
Sbjct: 3829 EPPSFIKTLEPADIV-RGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVC 3887
Query: 474 --LISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIK----LTAFPSESVKEGDTV 527
+ S D G Y C N+ G+ +++ P +K L A ++V
Sbjct: 3888 LEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTV-----T 3942
Query: 528 IISCTCGNVP--ETWIILKKKAETGDTVLKSIDGAYT---IRKAQLKDAGVYECESKNKV 582
+ + G+ P TW+ ++ + S I Q+ G Y C ++N+
Sbjct: 3943 LQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEA 4002
Query: 583 GSQ 585
GSQ
Sbjct: 4003 GSQ 4005
Score = 47.0 bits (110), Expect = 5e-05
Identities = 53/220 (24%), Positives = 85/220 (38%), Gaps = 24/220 (10%)
Query: 402 FEPKQRQSTQTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILWSRQ--- 457
F + +S+ TLYVN AP VL + ++ G + G P PKI W ++
Sbjct: 3220 FVAGRNRSSVTLYVN-APEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQL 3278
Query: 458 LPNG---ELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII---QVTPKDI 511
L G + + TL LI ED+ VY CE N G + L + +V D
Sbjct: 3279 LSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQ 3338
Query: 512 KLTAFPSESV--------KEGDTVIISCTCG--NVPETWIILKKKAETGDTV-LKSIDGA 560
++ +P + EG C ++ +W KK + + +
Sbjct: 3339 EMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT 3398
Query: 561 Y--TIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGREN 598
Y I +A +D G Y + N VG + L ++ E+
Sbjct: 3399 YQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPES 3438
Score = 47.0 bits (110), Expect = 5e-05
Identities = 45/181 (24%), Positives = 76/181 (41%), Gaps = 24/181 (13%)
Query: 435 GSSVNMTCLSQGFPAPKILWSR---QLPNGELQPLSENA---TLTLISTKMEDSGVYLCE 488
G + ++C G P P I W R +L +S + TLT+++ + ED GVY C
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCI 30606
Query: 489 GINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKE------GDTVIISCTCGNVP---ET 539
N+ G +L++Q TP+ P +KE G T+ + P T
Sbjct: 30607 ATNEVGEVETSSKLLLQATPQ-----FHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMT 30661
Query: 540 WIILKKKAETGDTVLKSIDGAYT---IRKAQLK-DAGVYECESKNKVGSQLRSLTLDVQG 595
W +K + + + YT ++ Q K AG Y+ + N G+ L +++Q
Sbjct: 30662 WFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQD 30721
Query: 596 R 596
+
Sbjct: 30722 K 30722
Score = 45.1 bits (105), Expect = 2e-04
Identities = 111/524 (21%), Positives = 193/524 (36%), Gaps = 73/524 (13%)
Query: 33 SRYLAQIGDSVSLT----CSTTGCESPFFSW----RTQIDSPLNGKVTNEGTTSTLTMNP 84
SR L + ++V L C+ +G E SW + DSP N + + T+TL +
Sbjct: 8060 SRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSP-NVQTSFLDNTATLNIFK 8118
Query: 85 VSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDP--EIHLSGPLEA--GKPITVKCSVA 140
Y CTAT ++ + P +I L+ P++A G+ +C V
Sbjct: 8119 TDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLA-PVDAVVGESADFECHVT 8177
Query: 141 DVYPFDRLEIDLLKGDHLMKSQ-----EFLEDADRKSL--ETKSLEVTFTP-VIEDIGKV 192
P +++ K ++S +LE++ ++ K +T + ++GK
Sbjct: 8178 GTQP---IKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKD 8234
Query: 193 LVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLP 252
C A+L+I E P+ + + E + + EG S + G
Sbjct: 8235 S-CTAQLNIKERLIPPSFTKRLSE----------------TVEETEGNSFKLEGRVAGSQ 8277
Query: 253 APEIFWSKK----LDNGNLQHLSGNATLTLIAMR--MEDSGIYVCEGVNLIGKNRKEVEL 306
+ W K N + N TL L + M D+G+Y C+ N G +
Sbjct: 8278 PITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSI 8337
Query: 307 IVQAFPRDPEIEMSGGLVN---GSSVTVSCKVPSVYPLDRLEIELLKGETILE-----NI 358
+++ + P + V G V +SC V P+ I+ LK ++ +
Sbjct: 8338 VIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPI---RIQWLKAGREIKPSDRCSF 8394
Query: 359 EFLEDTDMKSLEN--KSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVN 416
F T + L + K+ ++ + + ++K+ I D K + T
Sbjct: 8395 SFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKD-----KPAVAPATKKAA 8449
Query: 417 VAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWS----RQLPNGE---LQPLSEN 469
V R V S + E ++ G P P + W+ RQL G + +
Sbjct: 8450 VDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDE 8509
Query: 470 ATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKL 513
A L + T DSG+Y C N+ G V L + K K+
Sbjct: 8510 AKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQEKI 8553
Score = 44.7 bits (104), Expect = 3e-04
Identities = 48/209 (22%), Positives = 81/209 (38%), Gaps = 26/209 (12%)
Query: 325 NGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIED 384
+ +T S K P+V P E + T L F + D E +E+ +
Sbjct: 851 SAQKITKSVKAPTVKPS---ETRVRAEPTPLPQFPFADTPDTYKSE-AGVEVKKEVGVSI 906
Query: 385 TGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE--------EGS 436
TG + + FE + + P + V+P +++ EG
Sbjct: 907 TGTT--------VREERFEVLHGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGE 958
Query: 437 SVNMTCLSQGFPAPKILWSR---QLPNG---ELQPLSENATLTLISTKMEDSGVYLCEGI 490
SV + C G+P+P + W R Q+ + ++ S A L + EDSG + C +
Sbjct: 959 SVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAV 1018
Query: 491 NQAGRSRKEVELIIQVTPKDIKLTAFPSE 519
N+AG L +QV+ + K T +E
Sbjct: 1019 NEAGTVSTSCYLAVQVSEEFEKETTAVTE 1047
Score = 44.7 bits (104), Expect = 3e-04
Identities = 70/331 (21%), Positives = 118/331 (35%), Gaps = 54/331 (16%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGNLQHLS----GNATLTLIAMRMEDSG 287
++ EG VT C G P P+I W K++ +G + G A+L + + ED G
Sbjct: 1301 RILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEG 1360
Query: 288 IYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIE 347
IY N+ G +L V+ P P + +P++ P+ R I
Sbjct: 1361 IYTAFASNIKGNAICSGKLYVE--PAAP-------------LGAPTYIPTLEPVSR--IR 1403
Query: 348 LLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQR 407
L ++ + + M M+ P G+ L E
Sbjct: 1404 SLSPRSVSRSPIRMSPARMSPARMSPARMS--PARMSPGRRL-------------EETDE 1448
Query: 408 QSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQ 464
+ LY + VL S EG + G P P+ W +Q+ N
Sbjct: 1449 SQLERLY-----KPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTH 1503
Query: 465 P--LSENAT--LTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIK---LTAFP 517
+ E+ T L ++ DSG + N+AGRS V L ++ +K +
Sbjct: 1504 KVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLK 1563
Query: 518 SESVKEGDTVIISCTCGNVPETWIILKKKAE 548
+ ++KEG + + P I+ K ++
Sbjct: 1564 NVNIKEGSRLEMKVRATGNPNPDIVWLKNSD 1594
Score = 44.7 bits (104), Expect = 3e-04
Identities = 41/188 (21%), Positives = 78/188 (41%), Gaps = 23/188 (12%)
Query: 431 ILEEGSSVNMTCLSQGFPAPKILWSR------QLPNGELQPLSENATLTLISTKMEDSGV 484
I++ G S+ + L QG P P++ W + + N E+ + + +L + + GV
Sbjct: 27969 IIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGV 28028
Query: 485 YLCEGINQAGRSRKEVELIIQVTP----KDIKLTAFPSESVKEGDTVIISCTCGNVPE-- 538
Y E N +G ++ E+++ +Q TP I+ T E + ++ C +
Sbjct: 28029 YTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYI 28088
Query: 539 ---------TWIILKKKAETGD-TVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGSQLR 587
W +++ K E T +K I+G Y R + + GV + V +Q++
Sbjct: 28089 IEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQ 28148
Query: 588 SLTLDVQG 595
D G
Sbjct: 28149 YTVPDAPG 28156
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/87 (31%), Positives = 44/87 (50%), Gaps = 8/87 (9%)
Query: 233 STKLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGNLQHLSGNA---TLTLIAMRMEDS 286
+TKL G + ++C G P P+I W K+L +S + TLT++ ED
Sbjct: 30543 TTKL--GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDE 30600
Query: 287 GIYVCEGVNLIGKNRKEVELIVQAFPR 313
G+Y C N +G+ +L++QA P+
Sbjct: 30601 GVYTCIATNEVGEVETSSKLLLQATPQ 30627
Score = 44.3 bits (103), Expect = 4e-04
Identities = 51/223 (22%), Positives = 87/223 (39%), Gaps = 40/223 (17%)
Query: 311 FPRDPEIEMSGGLVNGSSVTVSCKVPSV---YPLDRLEIELLKGETILENIEFLEDTDMK 367
+P DP I++ GL+ ++V +S K P P+ +E L + E + +
Sbjct: 16010 YPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKR 16069
Query: 368 SLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPK--QRQSTQTLYVNVAPRDTTVL 425
+E E+ F T+ED + + EF K V P D
Sbjct: 16070 DVE----ELQF--TVEDLVEG---------GEYEFRVKAVNAAGVSKPSATVGPCDCQRP 16114
Query: 426 VSPSSI-------LEEGSSVNMTCLSQGFPAPKILWSRQLPN--GELQPL---------- 466
P SI +EEG++VN+ +G P P + W + P +P+
Sbjct: 16115 DMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLV 16174
Query: 467 -SENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP 508
+ TL + ++ D+G+Y +N G + KE+ L + P
Sbjct: 16175 VDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 16217
Score = 43.9 bits (102), Expect = 5e-04
Identities = 82/384 (21%), Positives = 139/384 (36%), Gaps = 45/384 (11%)
Query: 221 ISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK---LDNGNLQHLS---GNA 274
IS K +++ T + + G P P W+K + G LS G
Sbjct: 32848 ISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGF 32907
Query: 275 TLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCK 334
L + DSG+Y C N G +L ++A +D E + VS +
Sbjct: 32908 FLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAI-KDTEAQ-----------KVSTQ 32955
Query: 335 VPSVYPLDRLEIELLKGETILENI--EFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQ 392
S EI K + E I + L ++K E KS E + E+ K L+ +
Sbjct: 32956 KTS-------EITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALK--EEASKVLISE 33006
Query: 393 --AKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVL--VSPSSILEEGSSVNMTCLSQGFP 448
K +E + T+T + R + S + EG + + G
Sbjct: 33007 EVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGAT 33066
Query: 449 APK-ILWSRQLPNGE---LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII 504
K +L +L N E + TLT+ D G+ C + G + + +L +
Sbjct: 33067 DVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTL 33126
Query: 505 QVTPKDIK--LTAFPSESVKEGDTVIISCTCGNVPETWIILKKK----AETGDTVLKSID 558
D ++ S+++ EG V+ +C P I K + + + +
Sbjct: 33127 SKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSR 33186
Query: 559 GAYT--IRKAQLKDAGVYECESKN 580
Y+ IR A + D+G Y ++KN
Sbjct: 33187 NVYSLEIRNASVSDSGKYTIKAKN 33210
Score = 43.5 bits (101), Expect = 6e-04
Identities = 21/83 (25%), Positives = 43/83 (51%), Gaps = 6/83 (7%)
Query: 432 LEEGSSVNMTCLSQGFPAPKILWSR------QLPNGELQPLSENATLTLISTKMEDSGVY 485
++ G+ + + G P PKI W++ Q ++ + + +T+T++ +K D+G Y
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTY 13761
Query: 486 LCEGINQAGRSRKEVELIIQVTP 508
+ E +N GR+ VE+ + P
Sbjct: 13762 IIEAVNVCGRATAVVEVNVLDKP 13784
Score = 42.7 bits (99), Expect = 0.001
Identities = 121/608 (19%), Positives = 235/608 (38%), Gaps = 103/608 (16%)
Query: 40 GDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSY--- 93
G+S L G + +W +I N ++T + T L + + Y
Sbjct: 8264 GNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCK 8323
Query: 94 --------LCTATCESRKLEKGIQVEIYSFP----KDPEIHLSGPLEAGKPITVKCSVA- 140
LCT++ ++ +K + + P + + LS ++ +PI ++ A
Sbjct: 8324 VSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAG 8383
Query: 141 -DVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKL 199
++ P DR G +++ ++ + AD K+ V + ++K+
Sbjct: 8384 REIKPSDRCSFSFASGTAVLELRDVAK-ADSGDYVCKASNVAGSDTT---------KSKV 8433
Query: 200 HIDEMDSV-PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW 258
I + +V P ++A + +++ +S S ++ E + T G P P + W
Sbjct: 8434 TIKDKPAVAPATKKAAVDGRLFF------VSEPQSIRVVEKTTATFIAKVGGDPIPNVKW 8487
Query: 259 SK----KLDNGN---LQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAF 311
+K +L+ G + A L + DSG+Y C N G+ V L V
Sbjct: 8488 TKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDER 8547
Query: 312 PRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKG---ETILENIEFLEDTDMKS 368
+ +IE G + K P L KG E ++ +E L++ D K
Sbjct: 8548 KKQEKIE-------GDLRAMLKKTPI----------LKKGAGEEEEIDIMELLKNVDPKE 8590
Query: 369 LENKSLEMTFIPTIEDTGKA--LVCQA------KLHIDDMEFEPKQRQSTQTLYVNVAPR 420
E K M I +A L+ Q+ +L I+++E + + + L + R
Sbjct: 8591 YE-KYARMYGITDFRGLLQAFELLKQSQEEETHRLEIEEIERSERDEKEFEELVSFIQQR 8649
Query: 421 -----DTTVL--VSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLS--- 467
T++ + ++L++ +V + +P K+ W + +L + +S
Sbjct: 8650 LSQTEPVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEISIDG 8709
Query: 468 ENATLTLISTKMEDSGVY-LCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDT 526
+ TL + + +++D G Y L G + A +E + +D+ L KEG T
Sbjct: 8710 DRHTLRVKNCQLKDQGNYRLVCGPHIASAKLTVIEPAWERHLQDVTL--------KEGQT 8761
Query: 527 VIISC--TCGNVPETWI----ILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKN 580
++C + NV W ILK + V + TI + +D G Y C+ ++
Sbjct: 8762 CTMTCQFSVPNVKSEWFRNGRILKPQGRHKTEVEHKVH-KLTIADVRAEDQGQYTCKYED 8820
Query: 581 -KVGSQLR 587
+ ++LR
Sbjct: 8821 LETSAELR 8828
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/138 (27%), Positives = 64/138 (46%), Gaps = 14/138 (10%)
Query: 178 LEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQ 237
+ +T T V E+ +VL R + + E VP +++ ++P T++S + +
Sbjct: 904 VSITGTTVREERFEVLHGR-EAKVTETARVPA------PVEIPVTPP-TLVSGLKNVTVI 955
Query: 238 EGGSVTMTCSSEGLPAPEIFWSK---KLDNG---NLQHLSGNATLTLIAMRMEDSGIYVC 291
EG SVT+ C G P+P + W + ++++ + SG A L + EDSG + C
Sbjct: 956 EGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTC 1015
Query: 292 EGVNLIGKNRKEVELIVQ 309
VN G L VQ
Sbjct: 1016 SAVNEAGTVSTSCYLAVQ 1033
Score = 41.2 bits (95), Expect = 0.003
Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 12/94 (12%)
Query: 228 ISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK-----KLDNG-NLQHLSGNATLTLIAM 281
++V TK++ +VT G P P+I W+K K D ++++ +T+T++
Sbjct: 13700 LTVKAGTKIELPATVT------GKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDS 13753
Query: 282 RMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP 315
+ D+G Y+ E VN+ G+ VE+ V P P
Sbjct: 13754 KRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPP 13787
Score = 40.8 bits (94), Expect = 0.004
Identities = 31/118 (26%), Positives = 50/118 (42%), Gaps = 13/118 (11%)
Query: 228 ISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW----SKKLDNG---------NLQHLSGNA 274
I + +++EG +V + +G+P P + W KK DN N +
Sbjct: 16120 IDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTC 16179
Query: 275 TLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVS 332
TL + R D+G+Y VN +G KE+ L V P P + V+ +T+S
Sbjct: 16180 TLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLS 16237
Score = 39.7 bits (91), Expect = 0.009
Identities = 59/282 (20%), Positives = 106/282 (37%), Gaps = 33/282 (11%)
Query: 239 GGSVTMTCSSEGLPAPEIFW---SKKLDNGNLQHL---SGNATLTLIAMRMEDSGIYVCE 292
G + + + P E+ W +L + H SG TL ++ +DSG Y
Sbjct: 32388 GQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAV 32447
Query: 293 GVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVP-SVYPLDRLEIELLKG 351
N G+ L V G +S +VP SV+P + E
Sbjct: 32448 CTNYKGEASDYATLDVTG----------GDYTTYASQRRDEEVPRSVFP-ELTRTEAYAV 32496
Query: 352 ETILENIEFLEDTDMKSLENKSLEMT-FIPTIEDTGKALVCQAKLHIDDMEFEPKQRQST 410
+ + E + ++ ++++ E + + E + A + A L +E ++ +T
Sbjct: 32497 SSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLE----EKSTT 32552
Query: 411 QTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILWSRQ------LPNGEL 463
+ + +A R +L P S+ + EG S +C + G P P + W R+ ++
Sbjct: 32553 RKIKTTLAAR---ILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQV 32609
Query: 464 QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 505
+T + S + D G Y N G+ E L IQ
Sbjct: 32610 TTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQ 32651
Score = 39.3 bits (90), Expect = 0.011
Identities = 77/404 (19%), Positives = 138/404 (34%), Gaps = 48/404 (11%)
Query: 223 PKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK---LDNG---NLQHLSGNATL 276
P + + P T +Q G G P P+I W K+ L G H TL
Sbjct: 3238 PPQVLQELQPVT-VQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTL 3296
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIV---QAFPRDPEIEMSGGLV--------- 324
LI ED+ +Y CE N G L V + D E+ + +
Sbjct: 3297 LLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVT 3356
Query: 325 -NGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSL-------EM 376
G C+V L++ + ++ F T + + E
Sbjct: 3357 SEGQPARFQCRVSGT----DLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEG 3412
Query: 377 TFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEE-- 434
T+ + + A L ++ E +R + + + + V+ LE
Sbjct: 3413 TYTFVASNAVGQVSSTANLSLEAPESILHERIEQE---IEMEMKAAPVIKRKIEPLEVAL 3469
Query: 435 GSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLSEN---ATLTLISTKMEDSGVYLCE 488
G TC Q P + W R++ + + + ++L ++ T++ D G Y C+
Sbjct: 3470 GHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCK 3529
Query: 489 GINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKK-- 546
N+ G L + L+ S + G CT P I +K
Sbjct: 3530 ASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGA 3589
Query: 547 --AETGDTVLKSIDGAYTIRKAQL--KDAGVYECESKNKVGSQL 586
+ + + + + + + + L +D GVY C++ NK G+ +
Sbjct: 3590 ALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADI 3633
Score = 39.3 bits (90), Expect = 0.011
Identities = 42/176 (23%), Positives = 65/176 (36%), Gaps = 18/176 (10%)
Query: 436 SSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENA----TLTLISTKMEDSGVYLC 487
S+ + C G P P + W RQ + +G + E L + S +D+ VY
Sbjct: 30943 SNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQV 31002
Query: 488 EGINQAGRSRKEVELIIQVTPK---DIKLTAFPSESVKEGDTVIISCTCGNVPETWIILK 544
NQ G L ++V K L + G+ V I P+ I +
Sbjct: 31003 RATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ 31062
Query: 545 KKAETGDT-------VLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
K + D V +S + KDAG Y +KN+ G +++ LDV
Sbjct: 31063 KGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDV 31118
Score = 38.9 bits (89), Expect = 0.015
Identities = 30/117 (25%), Positives = 46/117 (39%), Gaps = 11/117 (9%)
Query: 233 STKLQEGGSVTMTCSSEGLPAPEIFW--------SKKLDNGNLQHLSGNATLTLIAMRME 284
S + EG + T G P PE+ W + L + G A LT+ A+
Sbjct: 14 SVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKA 73
Query: 285 DSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIE---MSGGLVNGSSVTVSCKVPSV 338
+SG Y + N G+ EL+V+A P S + GS V + +V +
Sbjct: 74 NSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGI 130
Score = 38.9 bits (89), Expect = 0.015
Identities = 23/83 (27%), Positives = 39/83 (46%), Gaps = 8/83 (9%)
Query: 432 LEEGSSVNMTCLSQGFPAPKILWSR--------QLPNGELQPLSENATLTLISTKMEDSG 483
++EGS + M + G P P I+W + + P ++ A L + ST +DS
Sbjct: 1567 IKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSA 1626
Query: 484 VYLCEGINQAGRSRKEVELIIQV 506
Y IN+AGR ++ ++V
Sbjct: 1627 WYTATAINKAGRDTTRCKVNVEV 1649
Score = 37.7 bits (86), Expect = 0.033
Identities = 26/117 (22%), Positives = 47/117 (40%), Gaps = 8/117 (6%)
Query: 233 STKLQEGGSVTMTCSSEGLPAPEIFWSKKLD--------NGNLQHLSGNATLTLIAMRME 284
+ ++EG + M + G P P+I W K D ++ G A L + + +
Sbjct: 1564 NVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQ 1623
Query: 285 DSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPL 341
DS Y +N G++ ++ V+ +PE E + G+ P + PL
Sbjct: 1624 DSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPL 1680
Score = 37.7 bits (86), Expect = 0.033
Identities = 90/421 (21%), Positives = 161/421 (38%), Gaps = 57/421 (13%)
Query: 208 PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK-LDNGN 266
P R + +L++ K TV ++ G S+ + S G P P I WSK+ +D +
Sbjct: 29437 PVERIEIPDLELADDLKKTVT-------IRAGASLRLMVSVSGRPPPVITWSKQGIDLAS 29489
Query: 267 LQHLSGNATLTLI---AMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRD-PEIEMSGG 322
+ + +L+ + D+G Y E N GK V + V P P +++
Sbjct: 29490 RAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKE- 29548
Query: 323 LVNGSSVTVSCKVPSV---YPLDRLEIELLKGETILENIEFLEDTDMKSL-------ENK 372
V+ SVT++ ++P++ P++ +E K E + + + K+L E
Sbjct: 29549 -VSRDSVTITWEIPTIDGGAPVNNYIVE--KREAAMRAFKTVTTKCSKTLYRISGLVEGT 29605
Query: 373 SLEMTFIP-TIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSI 431
+P I G+ + + ++ P + L V + T L +
Sbjct: 29606 MYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAK------LEVVDVTKSTVTLAWEKPL 29659
Query: 432 LEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGIN 491
+ GS + L A K R + L+P T+T S + ++ N
Sbjct: 29660 YDGGSRLTGYVLE----ACKAGTERWMKVVTLKPTVLEHTVT--SLNEGEQYLFRIRAQN 29713
Query: 492 QAGRSRKEVELIIQVTPKDIK------LTAFPSES--VKEGDTV-IISCTCGNVP--ETW 540
+ G S E + VT +D++ L+ P ++ V G V ++ G P +W
Sbjct: 29714 EKGVSEPR-ETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASW 29772
Query: 541 IILKKKAETGDTVLKSID---GAYTIRKAQLKDAGVYECESKNKVGS---QLRSLTLDVQ 594
K + V TIR+ ++D G Y E KN G+ ++ + LD
Sbjct: 29773 FFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKP 29832
Query: 595 G 595
G
Sbjct: 29833 G 29833
Score = 37.4 bits (85), Expect = 0.043
Identities = 31/132 (23%), Positives = 61/132 (46%), Gaps = 16/132 (12%)
Query: 457 QLPNGELQPLSENATLTLISTKMEDSGV--YLCEGINQAGRSRKEVELIIQVTP-KDIKL 513
Q P+ E++ + +L L + +++ +G + + + R + +I + P KD+ +
Sbjct: 12148 QTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTV 12207
Query: 514 TAFPSESVKEGDTVIISCTCG--NVPETWIILKKKAETGDTVLKSIDG---AYTIRKAQL 568
TA G+T C ++P W + KK E D V+ +G T+R +L
Sbjct: 12208 TA--------GETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKL 12259
Query: 569 KDAGVYECESKN 580
+DAG + +K+
Sbjct: 12260 EDAGEVQLTAKD 12271
Score = 37.4 bits (85), Expect = 0.043
Identities = 26/106 (24%), Positives = 45/106 (42%), Gaps = 12/106 (11%)
Query: 431 ILEEGSSVNMTCLSQGFPAPKILWSR-----QLPNGELQPLSENATLTLISTKMEDSGVY 485
I+ G + + + +G PAPK+ W + + G++ + A L + ++ +DSG Y
Sbjct: 18617 IVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKY 18676
Query: 486 LCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISC 531
+N AG V + + TP P +K D SC
Sbjct: 18677 SLTLVNPAGEKAVFVNVRVLDTPG-------PVSDLKVSDVTKTSC 18715
Score = 36.6 bits (83), Expect = 0.074
Identities = 86/384 (22%), Positives = 151/384 (39%), Gaps = 67/384 (17%)
Query: 242 VTMTCSSEGLPAPEIFW---SKKLDNGN---LQHLSGNATLTLIAMRMEDSGIYVCEGVN 295
+T+ S G P P W K L+ G+ ++ LS A L + D GIY + N
Sbjct: 13412 ITILVPSTGYPRPTATWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLEN 13471
Query: 296 LIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVP--------SVYPLDRLEIE 347
+ E+++ V A P P+ E+ G + SV ++ + P + Y +++ E+
Sbjct: 13472 RVKTISGEIDVNVIARPSAPK-ELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVS 13530
Query: 348 LLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIE-DTGKALVCQAKLHIDDMEFEPKQ 406
+++ + LE T ++ K + G+ +++ P
Sbjct: 13531 RKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDP 13590
Query: 407 RQSTQTLYVNVAPRDTT---VLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL 463
+ NV RD T + ++ +G S + + P W + GE
Sbjct: 13591 PE-------NVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKW---VACGE- 13639
Query: 464 QPLSENATLTLISTKMEDSGV-------YLCEGINQAGRSR-----KEVELI-IQVTPK- 509
P++E TKME +G+ Y + +N+ G S+ +E++ + Q P+
Sbjct: 13640 -PVAE--------TKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEI 13690
Query: 510 --DIKLTAFPSESVKEGDTVIISCTCGNVPE---TW-----IILKKKAETGDTVLKSIDG 559
D+KL A +VK G + + T PE TW I+ + K T + V K
Sbjct: 13691 FLDVKLLA--GLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKK--S 13746
Query: 560 AYTIRKAQLKDAGVYECESKNKVG 583
TI ++ D G Y E+ N G
Sbjct: 13747 TVTIVDSKRSDTGTYIIEAVNVCG 13770
Score = 36.6 bits (83), Expect = 0.074
Identities = 87/453 (19%), Positives = 151/453 (33%), Gaps = 106/453 (23%)
Query: 203 EMDSVPTVRQAVKELQVYISPKNT----VISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW 258
EM S ++++E K T +++ S + EG S +C ++G P P + W
Sbjct: 32535 EMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTW 32594
Query: 259 SKK--LDNGNLQH----LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFP 312
+K + + + +H +T + +++ D G Y N GK E L +Q
Sbjct: 32595 LRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQK-- 32652
Query: 313 RDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENK 372
V +VT +V S P +++ E ++
Sbjct: 32653 ---------ARVTEKAVTSPPRVKSPEPR-------------VKSPEAVKSPKRVKSPEP 32690
Query: 373 SLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSIL 432
S PT E +P + Q L V+ P+ T L + +S
Sbjct: 32691 SHPKAVSPT-------------------ETKPTPTEKVQHLPVSAPPKITQFLKAEAS-- 32729
Query: 433 EEGSSVNMTCLSQGFPAPKILW----SRQLPNGELQ-PLSENAT--LTLISTKMEDSGVY 485
+E + + S A ++ W + NG Q S + T L + + D G Y
Sbjct: 32730 KEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEY 32789
Query: 486 LCEGINQAGRSRKEVELIIQ----VTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE--- 538
+CE + G S+ ++ + Q + K K++ K ++ + T PE
Sbjct: 32790 VCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPIS 32849
Query: 539 -------------------TWIILKKKAETGDTVLKSIDGA------------------Y 561
+K E T + + DG
Sbjct: 32850 SKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFL 32909
Query: 562 TIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
I K D+G+Y C KN GS S L ++
Sbjct: 32910 EIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIK 32942
Score = 35.0 bits (79), Expect = 0.22
Identities = 31/106 (29%), Positives = 48/106 (45%), Gaps = 8/106 (7%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLD----NGNLQHLSGNATLTLI---AMRMEDSGIYVC 291
G V++ G P P I W K D NG+ Q + + +L+ + +D+G YV
Sbjct: 31042 GEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVV 31101
Query: 292 EGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPS 337
N G ++K VEL V P DP + V+ SV ++ P+
Sbjct: 31102 CAKNRFGIDQKTVELDVADVP-DPPRGVKVSDVSRDSVNLTWTEPA 31146
Score = 34.7 bits (78), Expect = 0.28
Identities = 23/94 (24%), Positives = 44/94 (46%), Gaps = 6/94 (6%)
Query: 38 QIGDSVSLTCSTTGCESPFFSWRT---QIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYL 94
++G++ L+C G P W ++ K++++G T TLT+ +E Y
Sbjct: 30545 KLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYT 30604
Query: 95 CTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLE 128
C AT E ++E ++ + + P+ H PL+
Sbjct: 30605 CIATNEVGEVETSSKLLLQA---TPQFHPGYPLK 30635
Score = 33.9 bits (76), Expect = 0.48
Identities = 47/199 (23%), Positives = 71/199 (35%), Gaps = 54/199 (27%)
Query: 433 EEGSSVNMTCLSQGFP-APKILWS---RQLPNGELQPLSENATLTLISTK---MEDSGVY 485
EEG V C + + + ++ W RQL N E ++ + ++ K D G Y
Sbjct: 31580 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTY 31639
Query: 486 LCEGINQAGRSRKEVELII-----------QVTPKDIK---------------------L 513
C+ +N G EL + + T K IK
Sbjct: 31640 RCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNK 31699
Query: 514 TAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDT----VLKSIDGAY--TIR 564
TA+ E+V+ G T+ + PE TW +K + GD +S G Y TI
Sbjct: 31700 TAYVGENVRFGVTITVH------PEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTIN 31753
Query: 565 KAQLKDAGVYECESKNKVG 583
D Y ++NK G
Sbjct: 31754 SVTTDDDAEYTVVARNKYG 31772
Score = 33.5 bits (75), Expect = 0.63
Identities = 20/99 (20%), Positives = 47/99 (47%), Gaps = 13/99 (13%)
Query: 432 LEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKM-------EDSGV 484
++ G ++ ++ + +G P PK+ W ++ + P +T + +K+ ED G+
Sbjct: 17230 IKVGDTLRLSAIIKGVPFPKVTWKKEDRDA---PTKARIDVTPVGSKLEIRNAAHEDGGI 17286
Query: 485 YLCEGINQAGRSRKEVELII---QVTPKDIKLTAFPSES 520
Y N AG V++++ P+D++++ +S
Sbjct: 17287 YSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDS 17325
Score = 33.5 bits (75), Expect = 0.63
Identities = 20/83 (24%), Positives = 37/83 (44%), Gaps = 6/83 (7%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSK------KLDNGNLQHLSGNATLTLIAMRMEDSGIY 289
++ G S+ + +G P P + W K K N + + G+ +L + + G+Y
Sbjct: 27970 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVY 28029
Query: 290 VCEGVNLIGKNRKEVELIVQAFP 312
E N G + E+++ VQ P
Sbjct: 28030 TVEAKNASGSAKAEIKVKVQDTP 28052
Score = 32.7 bits (73), Expect = 1.1
Identities = 26/111 (23%), Positives = 50/111 (45%), Gaps = 6/111 (5%)
Query: 489 GINQAGRSRKEVELIIQVTPKDIKLTAFPSESV---KEGDTVIISCTCGNVPET--WIIL 543
GI + G +E+ ++ D++L A + + G II+ G P T W +
Sbjct: 16502 GIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMN 16561
Query: 544 KKKAETGDTV-LKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
++ T+ +I + I+ Q GVY +KN+ G + +++ +DV
Sbjct: 16562 ERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDV 16612
Score = 32.3 bits (72), Expect = 1.4
Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 5/92 (5%)
Query: 249 EGLPAPEIFWSK----KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV 304
+G PAPE+ W++ LD +++ S L + + DSG Y+ N G V
Sbjct: 21885 KGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFV 21944
Query: 305 ELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVP 336
+ V P P+ ++ V +SVT++ P
Sbjct: 21945 NVRVLDTPGPPQ-DLKVKEVTKTSVTLTWDPP 21975
Score = 32.3 bits (72), Expect = 1.4
Identities = 19/61 (31%), Positives = 31/61 (50%), Gaps = 8/61 (13%)
Query: 431 ILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQ------PLSENATLTLISTKMEDSGV 484
I++ G+S MT +G P P +LWS+ P+ +L+ +LT+ + DSG
Sbjct: 26197 IVKAGASFTMTVPFRGRPVPNVLWSK--PDTDLRTRAYVDTTDSRTSLTIENANRNDSGK 26254
Query: 485 Y 485
Y
Sbjct: 26255 Y 26255
Score = 32.3 bits (72), Expect = 1.4
Identities = 27/106 (25%), Positives = 48/106 (45%), Gaps = 4/106 (3%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSKK-LDNGNLQHLSGNATLTLIAMRMED---SGIYVC 291
+++GG + +T +G P P W+K+ D ++ + T T + ++ D SG Y
Sbjct: 30148 VRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDL 30207
Query: 292 EGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPS 337
N GK +++ V P PE + + SV VS + P+
Sbjct: 30208 VLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPA 30253
Score = 32.0 bits (71), Expect = 1.8
Identities = 27/100 (27%), Positives = 45/100 (45%), Gaps = 7/100 (7%)
Query: 504 IQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETG---DTVLKSI 557
I VTP + ++ + +V EG++V + C P TW + E+ +S
Sbjct: 938 IPVTPPTL-VSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSG 996
Query: 558 DGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRE 597
IR+A +D+G + C + N+ G+ S L VQ E
Sbjct: 997 IARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSE 1036
Score = 32.0 bits (71), Expect = 1.8
Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 7/84 (8%)
Query: 519 ESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLK----SIDGAYTIRKAQLKDAGVY 574
+ +K GDT+ +S VP + KK+ T + + IR A +D G+Y
Sbjct: 17228 QHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIY 17287
Query: 575 ECESKNKVGSQ---LRSLTLDVQG 595
+N GS+ ++ L LD G
Sbjct: 17288 SLTVENPAGSKTVSVKVLVLDKPG 17311
Score = 32.0 bits (71), Expect = 1.8
Identities = 34/141 (24%), Positives = 59/141 (41%), Gaps = 21/141 (14%)
Query: 435 GSSVNMTCLSQGFPAPKILWSRQLP----NGELQPLSENATLTLI---STKMEDSGVYLC 487
G V++ G P P I W + NG Q + + +L+ + +D+G Y+
Sbjct: 31042 GEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVV 31101
Query: 488 EGINQAGRSRKEVELIIQVT---PKDIKLTAFPSESV--------KEGDTVI---ISCTC 533
N+ G +K VEL + P+ +K++ +SV +G + I I C
Sbjct: 31102 CAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKC 31161
Query: 534 GNVPETWIILKKKAETGDTVL 554
E W+ + + ET TV+
Sbjct: 31162 ATTAERWLRVGQARETRYTVI 31182
Score = 31.6 bits (70), Expect = 2.4
Identities = 74/357 (20%), Positives = 119/357 (33%), Gaps = 67/357 (18%)
Query: 282 RMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEI--EMSGGLVNGSSVTVSCKVPSVY 339
R D+G Y + G+NR V L V A P P++ E+ V C V S
Sbjct: 3211 RQSDAGEYTF----VAGRNRSSVTLYVNA-PEPPQVLQELQPVTVQSGKPARFCAVISGR 3265
Query: 340 PLDRLEIELLKGETILEN---IEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLH 396
P + I K E +L +FL D + + I + C+AK
Sbjct: 3266 PQPK--ISWYKEEQLLSTGFKCKFLHD-------GQEYTLLLIEAFPEDAAVYTCEAK-- 3314
Query: 397 IDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPS-------SILEEGSSVNMTCLSQGFPA 449
+D + + V+P + P+ ++ EG C G
Sbjct: 3315 -NDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL 3373
Query: 450 PKILWSRQLPNGELQP--------LSENATLTLISTKMEDSGVYLCEGINQAG------- 494
K+ W + + +++P + L + ED G Y N G
Sbjct: 3374 -KVSWYSK--DKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTAN 3430
Query: 495 ------------RSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPET--- 539
R +E+E+ ++ P IK P E V G +C + P
Sbjct: 3431 LSLEAPESILHERIEQEIEMEMKAAPV-IKRKIEPLE-VALGHLAKFTCEIQSAPNVRFQ 3488
Query: 540 WIILKKKAETGDTVL---KSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
W ++ D + I + Q+ D G Y C++ N+ GS + TL V
Sbjct: 3489 WFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 3545
Score = 31.6 bits (70), Expect = 2.4
Identities = 29/124 (23%), Positives = 52/124 (41%), Gaps = 21/124 (16%)
Query: 412 TLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR-----QLPNGELQPL 466
T+ + ++ R T+ V + G V++ G P PKI WS+ + P LQ
Sbjct: 15396 TIKLRLSVRGDTIKV------KAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQIT 15449
Query: 467 SENATLTLISTKM-------EDSGVYLCEGINQAGRSRKEVELII---QVTPKDIKLTAF 516
E + + T++ ED G Y N+ G + V + + P+++ +T
Sbjct: 15450 KEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDI 15509
Query: 517 PSES 520
+ES
Sbjct: 15510 KAES 15513
Score = 31.6 bits (70), Expect = 2.4
Identities = 42/169 (24%), Positives = 65/169 (38%), Gaps = 20/169 (11%)
Query: 228 ISVNPSTK----LQEGGSVTMTCSSEGLPAPEIFWSK---KLDNGNLQHLSGNATLTLIA 280
IS++P K + G S + G P P I W K +L N + T ++
Sbjct: 22543 ISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLS 22602
Query: 281 MR---MEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPS 337
++ DSG Y+ + N+ G+ V + V P PE + V T++ K P
Sbjct: 22603 VKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWKPPL 22662
Query: 338 V--------YPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTF 378
Y ++R E L + N++ L K LE E TF
Sbjct: 22663 QDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGN--EYTF 22709
Score = 31.2 bits (69), Expect = 3.1
Identities = 29/109 (26%), Positives = 51/109 (46%), Gaps = 9/109 (8%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQ---HLSGNATLTLIAM---RMEDSGIY 289
++ G S+ + +G PAPE+ W+K DN NL+ ++ + TL+ + D+G +
Sbjct: 20788 VRAGLSIRIFVPIKGRPAPEVTWTK--DNINLKNRANIENTESFTLLIIPECNRYDTGKF 20845
Query: 290 VCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSV 338
V N GK V + V P P + + + SVT+ +P +
Sbjct: 20846 VMTIENPAGKKSGFVNVRVLDTP-GPVLNLRPTDITKDSVTLHWDLPLI 20893
Score = 31.2 bits (69), Expect = 3.1
Identities = 17/68 (25%), Positives = 31/68 (45%), Gaps = 4/68 (5%)
Query: 431 ILEEGSSVNMTCLSQGFPAPKILWSRQLPN----GELQPLSENATLTLISTKMEDSGVYL 486
++ G+S+ + QG P P +WS+ N ++ +TLT+ + D+G Y
Sbjct: 28368 VVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYT 28427
Query: 487 CEGINQAG 494
N +G
Sbjct: 28428 LTVENNSG 28435
Score = 30.8 bits (68), Expect = 4.1
Identities = 79/379 (20%), Positives = 136/379 (35%), Gaps = 38/379 (10%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAMRMEDSGIYVC 291
++ GGS+ + +G P PE+ W K D + S +L L + DSG Y
Sbjct: 22954 IRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTL 23013
Query: 292 EGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSV--------YPLDR 343
N G V + V P P + + + SV+++ + P + Y +++
Sbjct: 23014 TLENSSGTKSAFVTVRVLDTP-SPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIVEK 23072
Query: 344 LEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFE 403
E ++ N + L+ + + G L Q I E
Sbjct: 23073 REATRKSYAAVVTNCH-KNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVP 23131
Query: 404 PKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL 463
Q + V+ R+ +V +S + +G S + + + WS L
Sbjct: 23132 ----QPPGKITVDDVTRN-SVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSL 23186
Query: 464 QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKL-----TAFPS 518
Q + N T + ++ +N+ GRS L + + KD+ + AF S
Sbjct: 23187 QAVITNLT-------QGEEYLFRVVAVNEKGRSDPR-SLAVPIVAKDLVIEPDVKPAFSS 23238
Query: 519 ESVKEGDTVIISCTCGNVPE---TWII--LKKKAETGDTVLKSID-GAYTIRKAQLKDAG 572
SV+ G + I P+ TW L K T V S+D +I++ D G
Sbjct: 23239 YSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGG 23298
Query: 573 VYECESKNKVGSQLRSLTL 591
Y N VG + S+ +
Sbjct: 23299 QYGITVANVVGQKTASIEI 23317
Score = 30.8 bits (68), Expect = 4.1
Identities = 32/132 (24%), Positives = 57/132 (43%), Gaps = 9/132 (6%)
Query: 191 KVLVCRA-KLHIDEMDSVPTVRQAVKELQVYISPKNTVIS-VNPSTKLQEGGSVTMTCSS 248
K+ VC K+ + E SVP + +L+ +P+ + S + ++ GGS +
Sbjct: 23992 KIRVCALNKVGLGEATSVPGTVKPEDKLE---APELDLDSELRKGIVVRAGGSARIHIPF 24048
Query: 249 EGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV 304
+G P PEI WS++ D ++ L++ D+G Y+ + N G V
Sbjct: 24049 KGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFV 24108
Query: 305 ELIVQAFPRDPE 316
+ V P P+
Sbjct: 24109 TVKVLDTPGPPQ 24120
Score = 30.8 bits (68), Expect = 4.1
Identities = 33/158 (20%), Positives = 63/158 (39%), Gaps = 13/158 (8%)
Query: 421 DTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWS------RQLPNGELQPLSENATLTL 474
D T + + + GS + G PAPK+ W ++ + + TLT+
Sbjct: 28648 DLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTV 28707
Query: 475 ISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISC--- 531
+ DSG Y N AG V +++ P + T S ++ ++S
Sbjct: 28708 KDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPV--TGPIEVSSVSAESCVLSWGEP 28765
Query: 532 TCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLK 569
G E + +K E+G T + ++ ++++ Q+K
Sbjct: 28766 KDGGGTEITNYIVEKRESGTTAWQLVNS--SVKRTQIK 28801
Score = 30.8 bits (68), Expect = 4.1
Identities = 22/106 (20%), Positives = 46/106 (43%), Gaps = 6/106 (5%)
Query: 239 GGSVTMTCSSEGLPAPEIFWS------KKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCE 292
G V + G P P W ++ + ++ + A LT+ + D+G Y E
Sbjct: 29753 GRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLE 29812
Query: 293 GVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSV 338
N+ G + +++I+ P P + ++ +S+T+S + P +
Sbjct: 29813 LKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPEL 29858
Score = 30.4 bits (67), Expect = 5.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 40 GDSVSLTCSTTGCESPFFSWRT---QIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G+SV+L C +G SP +W QI+S ++ ++T + + L + + + C+
Sbjct: 957 GESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCS 1016
Query: 97 ATCES 101
A E+
Sbjct: 1017 AVNEA 1021
Score = 30.4 bits (67), Expect = 5.3
Identities = 64/319 (20%), Positives = 113/319 (35%), Gaps = 62/319 (19%)
Query: 237 QEGGSVTMTCSSEGLP-APEIFWS---KKLDNGNLQHLS---GNATLTLIAMRMEDSGIY 289
+EGG V C E + ++ W ++L+N ++ G A L + + D G Y
Sbjct: 31580 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTY 31639
Query: 290 VCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKV---PSVYPLDRLEI 346
C+ VN G++ EL V+ + + T + ++ P + L
Sbjct: 31640 RCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNK 31699
Query: 347 ELLKGETILENIEFLE------------------DTDMK-SLENKS----LEMTFIPTIE 383
GE + + D D K + E+ L + + T +
Sbjct: 31700 TAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDD 31759
Query: 384 DTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSIL-----EEGSSV 438
D +V + K D + + T+ ++ P D+T+ +L +EG SV
Sbjct: 31760 DAEYTVVARNKYGEDSCK-------AKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSV 31812
Query: 439 NMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLI------------STKMEDSGVYL 486
G P P + W + + QPLS + +I T ED+G Y
Sbjct: 31813 CFEIRVSGIPPPTLKWEK-----DGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYR 31867
Query: 487 CEGINQAGRSRKEVELIIQ 505
N AG + + L ++
Sbjct: 31868 VTATNTAGSTSCQAHLQVE 31886
Score = 30.4 bits (67), Expect = 5.3
Identities = 30/101 (29%), Positives = 38/101 (37%), Gaps = 9/101 (8%)
Query: 513 LTAFPSESVKEGDTVIISCTCGNVPE---TWI----ILKKKAETGDTVLKSIDGAYTIRK 565
LT S +V EG++ SC P TW+ +L A T K + I
Sbjct: 32564 LTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTK-YKSTFEISS 32622
Query: 566 AQLKDAGVYECESKNKVGSQLRSLTLDVQ-GRENNKDYFSP 605
Q D G Y +N G Q TL +Q R K SP
Sbjct: 32623 VQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSP 32663
Score = 30.0 bits (66), Expect = 6.9
Identities = 25/101 (24%), Positives = 38/101 (37%), Gaps = 13/101 (12%)
Query: 228 ISVNPST-KLQEGGSVTMTCSSEGLPAPEIFWSK------------KLDNGNLQHLSGNA 274
+SV T K++ G V + GLP P+I WSK ++ +
Sbjct: 15401 LSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT 15460
Query: 275 TLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP 315
L++ ED G Y N +G + V + V P P
Sbjct: 15461 ELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSPP 15501
Score = 30.0 bits (66), Expect = 6.9
Identities = 27/137 (19%), Positives = 56/137 (40%), Gaps = 8/137 (5%)
Query: 206 SVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNG 265
S+P + V E + + P I + ++ G + + G P P W K D
Sbjct: 18882 SLPREAEGVYEAKEQLLPPK--ILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEV 18939
Query: 266 -NLQHLS-----GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEM 319
HL+ ++ L + + +DSG Y N G + ++++++V P P+
Sbjct: 18940 VTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPF 18999
Query: 320 SGGLVNGSSVTVSCKVP 336
++ + ++S +P
Sbjct: 19000 DISDIDADACSLSWHIP 19016
Score = 30.0 bits (66), Expect = 6.9
Identities = 25/101 (24%), Positives = 48/101 (47%), Gaps = 5/101 (4%)
Query: 431 ILEEGSSVNMTCLSQGFPAPKILWSR---QLPNGELQPLSENATLTLI-STKMEDSGVYL 486
++ G S+ + +G PAP++ W++ L N +E+ TL +I D+G ++
Sbjct: 20787 VVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFV 20846
Query: 487 CEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTV 527
N AG+ V + + TP + L P++ K+ T+
Sbjct: 20847 MTIENPAGKKSGFVNVRVLDTPGPV-LNLRPTDITKDSVTL 20886
Score = 29.6 bits (65), Expect = 9.0
Identities = 30/124 (24%), Positives = 55/124 (44%), Gaps = 12/124 (9%)
Query: 484 VYLCEGINQAGRSRKEVELIIQVTPKDIKLTA-----FPSESVKEGDTVIISCTCGNVPE 538
V+ +N+ GRS +L + V +DI++ F + +VK + + I P+
Sbjct: 25365 VFRVAAVNEKGRSDPR-QLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQ 25423
Query: 539 TWIILKKKAET-GDTVLKSIDGAYT-----IRKAQLKDAGVYECESKNKVGSQLRSLTLD 592
+ +K +T +T ++ + T I++A +D G YE N GS +T+
Sbjct: 25424 ATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITII 25483
Query: 593 VQGR 596
V R
Sbjct: 25484 VLDR 25487
Score = 29.6 bits (65), Expect = 9.0
Identities = 18/66 (27%), Positives = 26/66 (39%), Gaps = 4/66 (6%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAMRMEDSGIYVC 291
++ G S TMT G P P + WSK + +LT+ DSG Y
Sbjct: 26198 VKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTL 26257
Query: 292 EGVNLI 297
N++
Sbjct: 26258 TIQNVL 26263
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 92.4 bits (228), Expect = 1e-18
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 43/375 (11%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNLQ-----HLSGNATLTLIAMRMEDSGIYVCEG 293
G +V TC +EG P PEI W + + +++ +L + TL + + D GIY C
Sbjct: 260 GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMA 319
Query: 294 VNLIGKNR-KEVELIVQAFPRDPEIEM---SGGLVNGSSVTVSCKVPSVYPLDRLEIELL 349
N+ G+ + +EV L P P + + ++ G SVT+ C +P R I
Sbjct: 320 KNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATG-HPPPR--ISWT 376
Query: 350 KGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQS 409
+G+ + D + S + ++ C A +ID + +
Sbjct: 377 RGDRTPLPV------DPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVH-------A 423
Query: 410 TQTLYVNVAPRDTTVLVSPSS-ILEEGSSVNMTCLSQGFPAPKILWSR---QLPNGELQP 465
T + V P+ T V+P ++ EG +V+ C ++G P P I W++ QL
Sbjct: 424 TAFIIVQALPQFT---VTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHL 480
Query: 466 LSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ--VTPKDIKLTAFPSE-SVK 522
+ + TL + + D G Y C+ +N G + L +Q VTP + PS+ +V+
Sbjct: 481 VLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTP---VFASIPSDTTVE 537
Query: 523 EGDTVIISCTCGNVPETWIILKKK----AETGDTVLKSIDGAYTIRKAQLKDAGVYECES 578
G V + C+ PE I K E+G + S +G TI DAG YEC +
Sbjct: 538 VGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHI-SPEGFLTINDVGPADAGRYECVA 596
Query: 579 KNKVGSQLRSLTLDV 593
+N +GS S+ L V
Sbjct: 597 RNTIGSASVSMVLSV 611
Score = 74.7 bits (182), Expect = 2e-13
Identities = 76/311 (24%), Positives = 128/311 (41%), Gaps = 31/311 (9%)
Query: 217 LQVYISPKNTVISVNP-STKLQEGGSVTMTCSSEGLPAPEIFWSK----KLDNGNLQHLS 271
L+ + SP + P +T++ G SVT+ CS+ G P P I W++ L +++
Sbjct: 333 LRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNIT 392
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTV 331
+ L + + DSG Y C N I +IVQA P+ ++ G +V
Sbjct: 393 PSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDF 452
Query: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC 391
C+ P I + + S++ + L ++ T+ +G AL
Sbjct: 453 QCEAKGNPP---------------PVIAWTKGGSQLSVDRRHLVLS-SGTLRISGVALHD 496
Query: 392 QAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVS-PS-SILEEGSSVNMTCLSQGFPA 449
Q + + Q+ ++ V PR T V S PS + +E G++V + C SQG P
Sbjct: 497 QGQYECQAVNIIGSQK---VVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPE 553
Query: 450 PKILWSR---QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQV 506
P I W++ Q+ +S LT+ D+G Y C N G + V +++ V
Sbjct: 554 PAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSA--SVSMVLSV 611
Query: 507 TPKDIKLTAFP 517
D+ P
Sbjct: 612 NVPDVSRNGDP 622
Score = 64.7 bits (156), Expect = 3e-10
Identities = 56/188 (29%), Positives = 76/188 (40%), Gaps = 19/188 (10%)
Query: 417 VAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR----QLPNGELQPLSENATL 472
+ P++T VLV G SV + C + G P P+I W+R LP ++ + L
Sbjct: 346 IQPQNTEVLV--------GESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGL 397
Query: 473 TLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVK-EGDTVIISC 531
+ + DSG Y C N +I+Q P + T P + V EG TV C
Sbjct: 398 YIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALP---QFTVTPQDRVVIEGQTVDFQC 454
Query: 532 TC-GNVPE--TWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRS 588
GN P W + L G I L D G YEC++ N +GSQ
Sbjct: 455 EAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVV 514
Query: 589 LTLDVQGR 596
L VQ R
Sbjct: 515 AHLTVQPR 522
Score = 57.8 bits (138), Expect = 3e-08
Identities = 67/290 (23%), Positives = 113/290 (38%), Gaps = 31/290 (10%)
Query: 39 IGDSVSLTCSTTGCESPFFSWRTQIDSPLN-GKVTNEGTTSTLTMNPVSFGNEHSYLCTA 97
+G+SV+L CS TG P SW +PL N + L + V G+ Y C+A
Sbjct: 355 VGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSA 414
Query: 98 TCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDH 157
T + + + + P+ + G+ + +C P I KG
Sbjct: 415 TNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPP---PVIAWTKGGS 471
Query: 158 LMKSQEFLEDADRKSLETKSLEVTFTPV-IEDIGKVLVCRAKLHIDEMDSVPTVRQAVKE 216
+ DR+ L S + + V + D G+ E +V +
Sbjct: 472 QL-------SVDRRHLVLSSGTLRISGVALHDQGQY----------ECQAVNIIGSQKVV 514
Query: 217 LQVYISPKNTVI--SVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK---KLDNGNLQHLS 271
+ + P+ T + S+ T ++ G +V + CSS+G P P I W+K ++ H+S
Sbjct: 515 AHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHIS 574
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSG 321
LT+ + D+G Y C N IG + L V P++ +G
Sbjct: 575 PEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNV----PDVSRNG 620
Score = 53.1 bits (126), Expect = 8e-07
Identities = 75/319 (23%), Positives = 133/319 (41%), Gaps = 57/319 (17%)
Query: 40 GDSVSLTCSTTGCESPFFSW-------RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHS 92
G++V TC G P W + DS LN + ++GT L + ++
Sbjct: 260 GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLN--LLDDGT---LMIQNTQETDQGI 314
Query: 93 YLCTATCESRKLE-KGIQVEIYSFPKDPEIHL---SGPLEAGKPITVKCSVADVYPFDRL 148
Y C A + +++ + + + + P P + + + G+ +T++CS A +P R
Sbjct: 315 YQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECS-ATGHPPPR- 372
Query: 149 EIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVP 208
I +GD D + T S + V++ C A +ID + +
Sbjct: 373 -ISWTRGDRTPLP------VDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATA 425
Query: 209 TVRQAVKEL-QVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK-----KL 262
+ V+ L Q ++P++ V+ EG +V C ++G P P I W+K +
Sbjct: 426 FI--IVQALPQFTVTPQDRVVI--------EGQTVDFQCEAKGNPPPVIAWTKGGSQLSV 475
Query: 263 DNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQ--------AFPRD 314
D +L SG TL + + + D G Y C+ VN+IG + L VQ + P D
Sbjct: 476 DRRHLVLSSG--TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSD 533
Query: 315 PEIEMSGGLVNGSSVTVSC 333
+E+ G++V + C
Sbjct: 534 TTVEV------GANVQLPC 546
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 90.1 bits (222), Expect = 6e-18
Identities = 98/401 (24%), Positives = 162/401 (40%), Gaps = 56/401 (13%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFW-----SKKLDNGNLQHLSGNATLTLIAMRMEDSGIY 289
++ G +V TC +EG P PEI W S L++ ++ + TL + R D G+Y
Sbjct: 244 EVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVY 303
Query: 290 VCEGVNLIGKNRKEVELI-VQAFPRDPEIEMSGG---LVNGSSVTVSCKVPS-VYPLDRL 344
C N G+ + + ++ + P P + ++ G+S T+ C +PL
Sbjct: 304 QCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPL--- 360
Query: 345 EIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEP 404
I + D ++ ++ + T L Q D F
Sbjct: 361 -------------ITWTRDNGLELDGSRHVA---------TSSGLYLQNITQRDHGRFTC 398
Query: 405 KQRQSTQTLYVNV-----APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR--- 456
S T+ AP TV +LEE +V C + G P P I+W++
Sbjct: 399 HANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEE-HAVEWLCEADGNPPPVIVWTKTGG 457
Query: 457 QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKL-TA 515
QLP + + TL + D G Y C+ ++ G + V+L ++ PK + + T
Sbjct: 458 QLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVK--PKALAVFTQ 515
Query: 516 FPSE-SVKEGDTVIISCTCGNVPETWIILKKKA----ETGDTVLKSIDGAYTIRKAQLKD 570
P + SV+ G + ISC P+ I K+ E+G + +G TI A D
Sbjct: 516 LPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDD-EGTLTIYDAGFPD 574
Query: 571 AGVYECESKNKVGSQLRSLTLDV---QGRENNKDYFSPELL 608
G YEC ++N G + ++ L V QGR+ D+ +L
Sbjct: 575 QGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSIL 615
Score = 56.6 bits (135), Expect = 7e-08
Identities = 63/274 (22%), Positives = 112/274 (40%), Gaps = 38/274 (13%)
Query: 234 TKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNG----NLQHLSGNATLTLIAMRMEDSGIY 289
T++ G S T+ C + G P P I W++ DNG +H++ ++ L L + D G +
Sbjct: 339 TEVLIGTSTTLECMATGHPHPLITWTR--DNGLELDGSRHVATSSGLYLQNITQRDHGRF 396
Query: 290 VCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELL 349
C N G + +IVQA P+ +V P D++ +E
Sbjct: 397 TCHANNSHGTVQAAANIIVQAPPQF----------------------TVTPKDQVVLEEH 434
Query: 350 KGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQS 409
E + E + + L + T+ +G + +A H D ++E + S
Sbjct: 435 AVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQH-DQGQYECQAVSS 493
Query: 410 ----TQTLYVNVAPRDTTVL--VSPSSILEEGSSVNMTCLSQGFPAPKILWSR---QLPN 460
++ + V P+ V + + +E G ++N++C +QG P P I W++ Q+
Sbjct: 494 LGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITE 553
Query: 461 GELQPLSENATLTLISTKMEDSGVYLCEGINQAG 494
+ + TLT+ D G Y C N G
Sbjct: 554 SGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
Score = 45.8 bits (107), Expect = 1e-04
Identities = 57/275 (20%), Positives = 107/275 (38%), Gaps = 45/275 (16%)
Query: 39 IGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
IG S +L C TG P +W L+G + T+S L + ++ + + C A
Sbjct: 343 IGTSTTLECMATGHPHPLITWTRDNGLELDGS-RHVATSSGLYLQNITQRDHGRFTCHAN 401
Query: 99 CESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHL 158
++ + + + P+ V P D++ ++ +H
Sbjct: 402 NSHGTVQAAANIIVQAPPQ----------------------FTVTPKDQVVLE----EHA 435
Query: 159 MKSQEFLEDADRKS----LETKS---LEVTFTPVIEDIGKVLVCRAKLHID---EMDSVP 208
+ E+L +AD + TK+ L V + G + + RA H E +V
Sbjct: 436 V---EWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVS 492
Query: 209 TVRQAVKELQVYISPKNTVI--SVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK---KLD 263
++ +Q+ + PK + + T ++ G ++ ++C ++G P P I W+K ++
Sbjct: 493 SLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQIT 552
Query: 264 NGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIG 298
H+ TLT+ D G Y C N G
Sbjct: 553 ESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
Score = 42.4 bits (98), Expect = 0.001
Identities = 34/129 (26%), Positives = 57/129 (44%), Gaps = 29/129 (22%)
Query: 218 QVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNL----QH-LSG 272
Q ++PK+ V+ E +V C ++G P P I W+K G L QH +
Sbjct: 420 QFTVTPKDQVVL--------EEHAVEWLCEADGNPPPVIVWTKT--GGQLPVEGQHTVLS 469
Query: 273 NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQ--------AFPRDPEIEMSGGLV 324
+ TL + D G Y C+ V+ +G + V+L V+ P+D +E+
Sbjct: 470 SGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEV----- 524
Query: 325 NGSSVTVSC 333
G ++ +SC
Sbjct: 525 -GKNINISC 532
Score = 34.3 bits (77), Expect = 0.37
Identities = 22/78 (28%), Positives = 35/78 (44%), Gaps = 6/78 (7%)
Query: 512 KLTAFPSE-SVKEGDTVIISCTCGNVPET---WIILKKKAETGDTVLKSI--DGAYTIRK 565
++T P + V G+TV +C P+ WI + D ++ DG IR
Sbjct: 235 RITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRN 294
Query: 566 AQLKDAGVYECESKNKVG 583
+ D GVY+C ++N G
Sbjct: 295 TRESDQGVYQCMARNSAG 312
Score = 29.6 bits (65), Expect = 9.0
Identities = 21/92 (22%), Positives = 37/92 (40%), Gaps = 6/92 (6%)
Query: 9 LGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR---TQIDS 65
LG + + +A + T ++G +++++C G P +W QI
Sbjct: 494 LGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITE 553
Query: 66 PLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTA 97
V +EG TLT+ F ++ Y C A
Sbjct: 554 SGKFHVDDEG---TLTIYDAGFPDQGRYECVA 582
>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
Length = 1018
Score = 87.8 bits (216), Expect = 3e-17
Identities = 92/380 (24%), Positives = 151/380 (39%), Gaps = 56/380 (14%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLDN--GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNL 296
G +VT+ C + G P P+I W K L+ + + A L + +++ED GIY CE N+
Sbjct: 256 GQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENI 315
Query: 297 IGKNRKEVELIVQAFP------RDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLK 350
GK++ + + VQAFP D E+++ L V +P++ L + K
Sbjct: 316 RGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLY-WPCVATGKPIPTIRWL-KNGYAYHK 373
Query: 351 GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQST 410
GE L ++ F EN + E+T A+ A+L I
Sbjct: 374 GELRLYDVTF---------ENAGMYQCI---AENTYGAIYANAELKI------------- 408
Query: 411 QTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR---QLPNGELQPLS 467
+ +AP + + +G V + C + P PK WS+ L N +
Sbjct: 409 ----LALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIW 464
Query: 468 ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTV 527
E+ +L + + D G+Y C N G++ L+I P I L ++ + G+
Sbjct: 465 EDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVI-TDPTRIILAPINAD-ITVGENA 522
Query: 528 IISCTCGNVPETWIIL------------KKKAETGDTVLKSIDGAYTIRKAQLKDAGVYE 575
+ C P + K+ + +G IR AQLK AG Y
Sbjct: 523 TMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYT 582
Query: 576 CESKNKVGSQLRSLTLDVQG 595
C ++ V + S L V+G
Sbjct: 583 CTAQTIVDNSSASADLVVRG 602
Score = 43.5 bits (101), Expect = 6e-04
Identities = 73/345 (21%), Positives = 124/345 (35%), Gaps = 62/345 (17%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWRTQIDS-PLNGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
A +G +V+L C G P WR ++ P +++ G + L + + +E Y C
Sbjct: 253 ALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSG--AVLKIFNIQLEDEGIYEC 310
Query: 96 TATCESRKLEKGIQVEIYSFPK------DPEIHLSGPL-----EAGKPITVKCSVADVYP 144
A K + ++ + +FP+ D E+ + L GKPI + + Y
Sbjct: 311 EAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYA 370
Query: 145 FDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEM 204
+ + E+ L +VTF E+ G + C A+
Sbjct: 371 YHKGELRLY-------------------------DVTF----ENAG-MYQCIAE------ 394
Query: 205 DSVPTVRQAVKELQVYISPKNTVISVNPSTK---LQEGGSVTMTCSSEGLPAPEIFWSKK 261
T ++ I +NP K +GG V + C + P P+ WSK
Sbjct: 395 ---NTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKG 451
Query: 262 ---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIE 318
L N + + + +L + + D GIY C N GK L++ R
Sbjct: 452 TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 511
Query: 319 MSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETI---LENIEF 360
++ + G + T+ C LD + G I ENI +
Sbjct: 512 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHY 556
Score = 40.4 bits (93), Expect = 0.005
Identities = 67/292 (22%), Positives = 106/292 (36%), Gaps = 44/292 (15%)
Query: 234 TKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEG 293
T++ G + C + G P P I W L NG H L L + E++G+Y C
Sbjct: 340 TEVDIGSDLYWPCVATGKPIPTIRW---LKNGYAYH---KGELRLYDVTFENAGMYQCIA 393
Query: 294 VNLIGKNRKEVELIVQAFPRDPEIEMSGG-----LVNGSSVTVSCKVPSVYPLDRLEIEL 348
N G EL + A P EM+ G V + CK P P + +
Sbjct: 394 ENTYGAIYANAELKILALA--PTFEMNPMKKKILAAKGGRVIIECK-PKAAP--KPKFSW 448
Query: 349 LKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQ 408
KG L N + + E+ SLE+ I + G C A E +
Sbjct: 449 SKGTEWLVN-----SSRILIWEDGSLEINNI--TRNDGGIYTCFA-------ENNRGKAN 494
Query: 409 STQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKI--LWS----------R 456
ST TL + R +L ++ + G + M C + PA + +WS
Sbjct: 495 STGTLVITDPTR--IILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKE 552
Query: 457 QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP 508
+ L N L + + +++ +G Y C S +L+++ P
Sbjct: 553 NIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPP 604
Score = 32.7 bits (73), Expect = 1.1
Identities = 30/117 (25%), Positives = 51/117 (43%), Gaps = 20/117 (17%)
Query: 426 VSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLT----LIST--KM 479
+ P LE V++ C ++ P P W ++ NG++ S+ ++ +I+ K
Sbjct: 51 IYPEESLE--GKVSLNCRARASPFPVYKW--RMNNGDVDLTSDRYSMVGGNLVINNPDKQ 106
Query: 480 EDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSES-----VKEGDTVIISC 531
+D+G+Y C N G R + T L FP E VKEG +++ C
Sbjct: 107 KDAGIYYCLASNNYGMVRS-----TEATLSFGYLDPFPPEERPEVRVKEGKGMVLLC 158
Score = 32.0 bits (71), Expect = 1.8
Identities = 59/296 (19%), Positives = 114/296 (38%), Gaps = 51/296 (17%)
Query: 39 IGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
IG + C TG P W NG ++G L + V+F N Y C A
Sbjct: 344 IGSDLYWPCVATGKPIPTIRWLK------NGYAYHKGE---LRLYDVTFENAGMYQCIAE 394
Query: 99 CESRKLEKGIQVEIYSFPKDPEIHLSGPLEA------GKPITVKCSVADVYPFDRLEIDL 152
+ +++I + E++ P++ G + ++C P +
Sbjct: 395 NTYGAIYANAELKILALAPTFEMN---PMKKKILAAKGGRVIIECK-PKAAPKPKFSWS- 449
Query: 153 LKGDHLMKSQEFLEDADRKSL-ETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVR 211
K E+L ++ R + E SLE+ + + G + C A+ + + +S T+
Sbjct: 450 -------KGTEWLVNSSRILIWEDGSLEIN--NITRNDGGIYTCFAENNRGKANSTGTL- 499
Query: 212 QAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEI--FWSKK-----LDN 264
++ ++P N I+V G + TM C++ PA ++ WS +
Sbjct: 500 VITDPTRIILAPINADITV--------GENATMQCAASFDPALDLTFVWSFNGYVIDFNK 551
Query: 265 GNLQH-----LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP 315
N+ + L N L + +++ +G Y C ++ + +L+V+ P P
Sbjct: 552 ENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPP 607
>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
Length = 1007
Score = 87.8 bits (216), Expect = 3e-17
Identities = 92/380 (24%), Positives = 151/380 (39%), Gaps = 56/380 (14%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLDN--GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNL 296
G +VT+ C + G P P+I W K L+ + + A L + +++ED GIY CE N+
Sbjct: 245 GQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENI 304
Query: 297 IGKNRKEVELIVQAFP------RDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLK 350
GK++ + + VQAFP D E+++ L V +P++ L + K
Sbjct: 305 RGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLY-WPCVATGKPIPTIRWL-KNGYAYHK 362
Query: 351 GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQST 410
GE L ++ F EN + E+T A+ A+L I
Sbjct: 363 GELRLYDVTF---------ENAGMYQCI---AENTYGAIYANAELKI------------- 397
Query: 411 QTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR---QLPNGELQPLS 467
+ +AP + + +G V + C + P PK WS+ L N +
Sbjct: 398 ----LALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIW 453
Query: 468 ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTV 527
E+ +L + + D G+Y C N G++ L+I P I L ++ + G+
Sbjct: 454 EDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVI-TDPTRIILAPINAD-ITVGENA 511
Query: 528 IISCTCGNVPETWIIL------------KKKAETGDTVLKSIDGAYTIRKAQLKDAGVYE 575
+ C P + K+ + +G IR AQLK AG Y
Sbjct: 512 TMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYT 571
Query: 576 CESKNKVGSQLRSLTLDVQG 595
C ++ V + S L V+G
Sbjct: 572 CTAQTIVDNSSASADLVVRG 591
Score = 43.5 bits (101), Expect = 6e-04
Identities = 73/345 (21%), Positives = 124/345 (35%), Gaps = 62/345 (17%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWRTQIDS-PLNGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
A +G +V+L C G P WR ++ P +++ G + L + + +E Y C
Sbjct: 242 ALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSG--AVLKIFNIQLEDEGIYEC 299
Query: 96 TATCESRKLEKGIQVEIYSFPK------DPEIHLSGPL-----EAGKPITVKCSVADVYP 144
A K + ++ + +FP+ D E+ + L GKPI + + Y
Sbjct: 300 EAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYA 359
Query: 145 FDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEM 204
+ + E+ L +VTF E+ G + C A+
Sbjct: 360 YHKGELRLY-------------------------DVTF----ENAG-MYQCIAE------ 383
Query: 205 DSVPTVRQAVKELQVYISPKNTVISVNPSTK---LQEGGSVTMTCSSEGLPAPEIFWSKK 261
T ++ I +NP K +GG V + C + P P+ WSK
Sbjct: 384 ---NTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKG 440
Query: 262 ---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIE 318
L N + + + +L + + D GIY C N GK L++ R
Sbjct: 441 TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 500
Query: 319 MSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETI---LENIEF 360
++ + G + T+ C LD + G I ENI +
Sbjct: 501 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHY 545
Score = 40.4 bits (93), Expect = 0.005
Identities = 67/292 (22%), Positives = 106/292 (36%), Gaps = 44/292 (15%)
Query: 234 TKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEG 293
T++ G + C + G P P I W L NG H L L + E++G+Y C
Sbjct: 329 TEVDIGSDLYWPCVATGKPIPTIRW---LKNGYAYH---KGELRLYDVTFENAGMYQCIA 382
Query: 294 VNLIGKNRKEVELIVQAFPRDPEIEMSGG-----LVNGSSVTVSCKVPSVYPLDRLEIEL 348
N G EL + A P EM+ G V + CK P P + +
Sbjct: 383 ENTYGAIYANAELKILALA--PTFEMNPMKKKILAAKGGRVIIECK-PKAAP--KPKFSW 437
Query: 349 LKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQ 408
KG L N + + E+ SLE+ I + G C A E +
Sbjct: 438 SKGTEWLVN-----SSRILIWEDGSLEINNI--TRNDGGIYTCFA-------ENNRGKAN 483
Query: 409 STQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKI--LWS----------R 456
ST TL + R +L ++ + G + M C + PA + +WS
Sbjct: 484 STGTLVITDPTR--IILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKE 541
Query: 457 QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP 508
+ L N L + + +++ +G Y C S +L+++ P
Sbjct: 542 NIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPP 593
Score = 32.7 bits (73), Expect = 1.1
Identities = 30/117 (25%), Positives = 51/117 (43%), Gaps = 20/117 (17%)
Query: 426 VSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLT----LIST--KM 479
+ P LE V++ C ++ P P W ++ NG++ S+ ++ +I+ K
Sbjct: 40 IYPEESLE--GKVSLNCRARASPFPVYKW--RMNNGDVDLTSDRYSMVGGNLVINNPDKQ 95
Query: 480 EDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSES-----VKEGDTVIISC 531
+D+G+Y C N G R + T L FP E VKEG +++ C
Sbjct: 96 KDAGIYYCLASNNYGMVRS-----TEATLSFGYLDPFPPEERPEVRVKEGKGMVLLC 147
Score = 32.0 bits (71), Expect = 1.8
Identities = 59/296 (19%), Positives = 114/296 (38%), Gaps = 51/296 (17%)
Query: 39 IGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
IG + C TG P W NG ++G L + V+F N Y C A
Sbjct: 333 IGSDLYWPCVATGKPIPTIRWLK------NGYAYHKGE---LRLYDVTFENAGMYQCIAE 383
Query: 99 CESRKLEKGIQVEIYSFPKDPEIHLSGPLEA------GKPITVKCSVADVYPFDRLEIDL 152
+ +++I + E++ P++ G + ++C P +
Sbjct: 384 NTYGAIYANAELKILALAPTFEMN---PMKKKILAAKGGRVIIECK-PKAAPKPKFSWS- 438
Query: 153 LKGDHLMKSQEFLEDADRKSL-ETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVR 211
K E+L ++ R + E SLE+ + + G + C A+ + + +S T+
Sbjct: 439 -------KGTEWLVNSSRILIWEDGSLEIN--NITRNDGGIYTCFAENNRGKANSTGTL- 488
Query: 212 QAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEI--FWSKK-----LDN 264
++ ++P N I+V G + TM C++ PA ++ WS +
Sbjct: 489 VITDPTRIILAPINADITV--------GENATMQCAASFDPALDLTFVWSFNGYVIDFNK 540
Query: 265 GNLQH-----LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP 315
N+ + L N L + +++ +G Y C ++ + +L+V+ P P
Sbjct: 541 ENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPP 596
>gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens]
Length = 727
Score = 87.8 bits (216), Expect = 3e-17
Identities = 97/390 (24%), Positives = 158/390 (40%), Gaps = 55/390 (14%)
Query: 228 ISVNPSTKLQEGGSVTMTC-SSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDS 286
I VNP G ++T+ C ++ G PAP + W + + + TLT+ A+ +D+
Sbjct: 23 IVVNP------GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDA 76
Query: 287 GIYVCEGVNLIGK-NRKEVELIVQAFPR-------DPEIEMSGGLVNGSSVTVSCKVPSV 338
G Y C N +G +K +IV+A + DP + G V +SC+V +V
Sbjct: 77 GTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDP-YHKDDNIQIGREVKISCQVEAV 135
Query: 339 YPLDRLEIELLKGETILENIEFL----EDTDMK----SLENKSLEMTFIPTIEDTGKALV 390
P + L K L + E + D D+ +L+ L+ T T
Sbjct: 136 -PSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGT-------YT 187
Query: 391 CQAKLH---IDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGF 447
C A L I D+ + ST V P T + EG ++ + C G
Sbjct: 188 CVASLKGGGISDISIDVNISSST------VPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
Query: 448 PAPKILWSR-----QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVEL 502
P P ILWSR +P+G +Q S + TL +++ E SG+Y C+ G + K E
Sbjct: 242 PKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREA 301
Query: 503 IIQ--------VTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVL 554
++Q V P +++ SV V+ + + W + K TG
Sbjct: 302 LVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDS 361
Query: 555 KSIDGAYTIRKAQLKDAGVYECESKNKVGS 584
+ Y ++ ++ GVY C N+ G+
Sbjct: 362 QEYT-EYAVKSLSNENYGVYNCSIINEAGA 390
Score = 80.9 bits (198), Expect = 3e-15
Identities = 91/377 (24%), Positives = 154/377 (40%), Gaps = 45/377 (11%)
Query: 40 GDSVSLTCSTTGCE-SPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
G++++L C TTG E +P +W + V N GT LT+ ++ + +Y C A
Sbjct: 28 GEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGT---LTIPAITSDDAGTYSCIAN 84
Query: 99 CE-SRKLEKGIQVEIYSFPK-------DPEIHLSGPLEAGKPITVKCSVADVYPFDRLEI 150
+K + + + K DP H ++ G+ + + C V V P + L
Sbjct: 85 NNVGNPAKKSTNIIVRALKKGRFWITPDP-YHKDDNIQIGREVKISCQVEAV-PSEELTF 142
Query: 151 DLLKGDHLMKSQEFL------EDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEM 204
K ++S E + D + +++ FT D G C A L +
Sbjct: 143 SWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT----DFG-TYTCVASL---KG 194
Query: 205 DSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK---- 260
+ + V + P TV +EG ++ + C G P P I WS+
Sbjct: 195 GGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKE 254
Query: 261 -KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPE--- 316
+ +G++Q S + TL ++ + E SG+Y C+ G N K E +VQ + P
Sbjct: 255 VAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVE 314
Query: 317 ---IEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEF----LEDTDMKSL 369
+E+ G SVT+SC+V YP+ L E G +L +F + +KSL
Sbjct: 315 PAFLEIRQG--QDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSL 372
Query: 370 ENKSLEMTFIPTIEDTG 386
N++ + I + G
Sbjct: 373 SNENYGVYNCSIINEAG 389
Score = 47.8 bits (112), Expect = 3e-05
Identities = 47/196 (23%), Positives = 81/196 (41%), Gaps = 34/196 (17%)
Query: 424 VLVSPSSILEEGSSVNMTCLSQGF-PAPKILWSRQLPNGELQPLSENATLTLISTKMEDS 482
+LV ++ G ++ + C++ G PAP + W R + + TLT+ + +D+
Sbjct: 17 LLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDA 76
Query: 483 GVYLCEGINQAGR-SRKEVELIIQVTPKD-IKLTAFP---SESVKEGDTVIISCTCGNVP 537
G Y C N G ++K +I++ K +T P ++++ G V ISC VP
Sbjct: 77 GTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVP 136
Query: 538 ------------------ETWIILKKKAET--GDTVLKSIDGAYTIRKAQLKDAGVYECE 577
E +I + + G T L ID +T D G Y C
Sbjct: 137 SEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT-------DFGTYTCV 189
Query: 578 SKNKVGSQLRSLTLDV 593
+ K G + +++DV
Sbjct: 190 ASLK-GGGISDISIDV 204
Score = 42.4 bits (98), Expect = 0.001
Identities = 40/179 (22%), Positives = 75/179 (41%), Gaps = 24/179 (13%)
Query: 432 LEEGSSVNMTCLSQGFPAPKILWS-----RQLPNGELQPLSEN--------ATLTLISTK 478
++ G V ++C + P+ ++ +S R L + E +++ L +I K
Sbjct: 120 IQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLK 179
Query: 479 MEDSGVYLC-EGINQAGRSRKEVELIIQVTPKDIKLTAFPSES---VKEGDTVIISCTCG 534
D G Y C + G S +++ I + LT +S +EGDT+ + C
Sbjct: 180 FTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVT 239
Query: 535 NVPETWIILKKKAET------GDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLR 587
P+ IIL +A+ G ++S DG I + +G+Y C++ G ++
Sbjct: 240 GKPKP-IILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVK 297
Score = 36.6 bits (83), Expect = 0.074
Identities = 41/171 (23%), Positives = 68/171 (39%), Gaps = 14/171 (8%)
Query: 32 ESRYLAQIGDSVSLTCSTTGCESPFFSWR---TQIDSPLNGKVTNEGTTSTLTMNPVSFG 88
+S + + GD++ L C TG P W ++ P +G + E TL + VS
Sbjct: 221 KSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMP-DGSMQMESYDGTLRIVNVSRE 279
Query: 89 NEHSYLCTAT----CESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYP 144
Y C + + E +Q+ + P L + +T+ C V YP
Sbjct: 280 MSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYP 339
Query: 145 FDRLEIDLLKGDHLMK-----SQEFLEDADRKSLETKSLEVTFTPVIEDIG 190
L + G+ L++ SQE+ E A KSL ++ V +I + G
Sbjct: 340 IRVLTYEWRLGNKLLRTGQFDSQEYTEYA-VKSLSNENYGVYNCSIINEAG 389
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 87.0 bits (214), Expect = 5e-17
Identities = 131/537 (24%), Positives = 213/537 (39%), Gaps = 69/537 (12%)
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-GKPITVKCSVADVYPFDRLE 149
H YL C L G ++ FP H S + + G+P T+ C A+ P +E
Sbjct: 7 HFYLFGLIC----LCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK-AEGRPTPTIE 61
Query: 150 IDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIE------DIGKVLVCRAKLHIDE 203
KG +++ + + R L + SL F ++ D G V VC A+ ++ E
Sbjct: 62 --WYKGGERVETDKDDPRSHRMLLPSGSL--FFLRIVHGRKSRPDEG-VYVCVARNYLGE 116
Query: 204 MDSV-PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS-EGLPAPEIFWSKK 261
S ++ A+ +P + +++V G M C G P P I W K
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAV--------GEPAVMECQPPRGHPEPTISWKKD 168
Query: 262 ---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQAFPRDPEI 317
LD+ + + L + R D+G YVC G N++G+ EV EL V P +
Sbjct: 169 GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKR 228
Query: 318 EMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMT 377
+ + S C+ P+ + GE E +D +K +
Sbjct: 229 PSNLAVTVDDSAEFKCEARG-DPVPTVRWRKDDGELPKSRYEIRDDHTLKIRK------- 280
Query: 378 FIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSP-SSILEEGS 436
T D G + C A+ + E ++ TL V V +V P ++ G
Sbjct: 281 --VTAGDMG-SYTCVAENMVGKAE-------ASATLTVQVGSEPPHFVVKPRDQVVALGR 330
Query: 437 SVNMTCLSQGFPAPKILWSRQLPNGEL---QP--------LSENATLTLISTKMEDSGVY 485
+V C + G P P I W R+ L QP +S+ LT+ + + D G Y
Sbjct: 331 TVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYY 390
Query: 486 LCEGINQAG----RSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWI 541
+C+ +N AG ++ EV +I P + +++V T ++SC P I
Sbjct: 391 ICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTI 450
Query: 542 ILKKK---AETGDTVLKSID-GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
+ +K T D+ +K ++ G IR A+L D G Y C + G S ++VQ
Sbjct: 451 LWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 87.0 bits (214), Expect = 5e-17
Identities = 131/537 (24%), Positives = 213/537 (39%), Gaps = 69/537 (12%)
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-GKPITVKCSVADVYPFDRLE 149
H YL C L G ++ FP H S + + G+P T+ C A+ P +E
Sbjct: 7 HFYLFGLIC----LCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK-AEGRPTPTIE 61
Query: 150 IDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIE------DIGKVLVCRAKLHIDE 203
KG +++ + + R L + SL F ++ D G V VC A+ ++ E
Sbjct: 62 --WYKGGERVETDKDDPRSHRMLLPSGSL--FFLRIVHGRKSRPDEG-VYVCVARNYLGE 116
Query: 204 MDSV-PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS-EGLPAPEIFWSKK 261
S ++ A+ +P + +++V G M C G P P I W K
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAV--------GEPAVMECQPPRGHPEPTISWKKD 168
Query: 262 ---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQAFPRDPEI 317
LD+ + + L + R D+G YVC G N++G+ EV EL V P +
Sbjct: 169 GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKR 228
Query: 318 EMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMT 377
+ + S C+ P+ + GE E +D +K +
Sbjct: 229 PSNLAVTVDDSAEFKCEARG-DPVPTVRWRKDDGELPKSRYEIRDDHTLKIRK------- 280
Query: 378 FIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSP-SSILEEGS 436
T D G + C A+ + E ++ TL V V +V P ++ G
Sbjct: 281 --VTAGDMG-SYTCVAENMVGKAE-------ASATLTVQVGSEPPHFVVKPRDQVVALGR 330
Query: 437 SVNMTCLSQGFPAPKILWSRQLPNGEL---QP--------LSENATLTLISTKMEDSGVY 485
+V C + G P P I W R+ L QP +S+ LT+ + + D G Y
Sbjct: 331 TVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYY 390
Query: 486 LCEGINQAG----RSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWI 541
+C+ +N AG ++ EV +I P + +++V T ++SC P I
Sbjct: 391 ICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTI 450
Query: 542 ILKKK---AETGDTVLKSID-GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
+ +K T D+ +K ++ G IR A+L D G Y C + G S ++VQ
Sbjct: 451 LWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 87.0 bits (214), Expect = 5e-17
Identities = 131/537 (24%), Positives = 213/537 (39%), Gaps = 69/537 (12%)
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-GKPITVKCSVADVYPFDRLE 149
H YL C L G ++ FP H S + + G+P T+ C A+ P +E
Sbjct: 7 HFYLFGLIC----LCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK-AEGRPTPTIE 61
Query: 150 IDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIE------DIGKVLVCRAKLHIDE 203
KG +++ + + R L + SL F ++ D G V VC A+ ++ E
Sbjct: 62 --WYKGGERVETDKDDPRSHRMLLPSGSL--FFLRIVHGRKSRPDEG-VYVCVARNYLGE 116
Query: 204 MDSV-PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS-EGLPAPEIFWSKK 261
S ++ A+ +P + +++V G M C G P P I W K
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAV--------GEPAVMECQPPRGHPEPTISWKKD 168
Query: 262 ---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQAFPRDPEI 317
LD+ + + L + R D+G YVC G N++G+ EV EL V P +
Sbjct: 169 GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKR 228
Query: 318 EMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMT 377
+ + S C+ P+ + GE E +D +K +
Sbjct: 229 PSNLAVTVDDSAEFKCEARG-DPVPTVRWRKDDGELPKSRYEIRDDHTLKIRK------- 280
Query: 378 FIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSP-SSILEEGS 436
T D G + C A+ + E ++ TL V V +V P ++ G
Sbjct: 281 --VTAGDMG-SYTCVAENMVGKAE-------ASATLTVQVGSEPPHFVVKPRDQVVALGR 330
Query: 437 SVNMTCLSQGFPAPKILWSRQLPNGEL---QP--------LSENATLTLISTKMEDSGVY 485
+V C + G P P I W R+ L QP +S+ LT+ + + D G Y
Sbjct: 331 TVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYY 390
Query: 486 LCEGINQAG----RSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWI 541
+C+ +N AG ++ EV +I P + +++V T ++SC P I
Sbjct: 391 ICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTI 450
Query: 542 ILKKK---AETGDTVLKSID-GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
+ +K T D+ +K ++ G IR A+L D G Y C + G S ++VQ
Sbjct: 451 LWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 87.0 bits (214), Expect = 5e-17
Identities = 131/537 (24%), Positives = 213/537 (39%), Gaps = 69/537 (12%)
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-GKPITVKCSVADVYPFDRLE 149
H YL C L G ++ FP H S + + G+P T+ C A+ P +E
Sbjct: 7 HFYLFGLIC----LCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK-AEGRPTPTIE 61
Query: 150 IDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIE------DIGKVLVCRAKLHIDE 203
KG +++ + + R L + SL F ++ D G V VC A+ ++ E
Sbjct: 62 --WYKGGERVETDKDDPRSHRMLLPSGSL--FFLRIVHGRKSRPDEG-VYVCVARNYLGE 116
Query: 204 MDSV-PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS-EGLPAPEIFWSKK 261
S ++ A+ +P + +++V G M C G P P I W K
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAV--------GEPAVMECQPPRGHPEPTISWKKD 168
Query: 262 ---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQAFPRDPEI 317
LD+ + + L + R D+G YVC G N++G+ EV EL V P +
Sbjct: 169 GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKR 228
Query: 318 EMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMT 377
+ + S C+ P+ + GE E +D +K +
Sbjct: 229 PSNLAVTVDDSAEFKCEARG-DPVPTVRWRKDDGELPKSRYEIRDDHTLKIRK------- 280
Query: 378 FIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSP-SSILEEGS 436
T D G + C A+ + E ++ TL V V +V P ++ G
Sbjct: 281 --VTAGDMG-SYTCVAENMVGKAE-------ASATLTVQVGSEPPHFVVKPRDQVVALGR 330
Query: 437 SVNMTCLSQGFPAPKILWSRQLPNGEL---QP--------LSENATLTLISTKMEDSGVY 485
+V C + G P P I W R+ L QP +S+ LT+ + + D G Y
Sbjct: 331 TVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYY 390
Query: 486 LCEGINQAG----RSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWI 541
+C+ +N AG ++ EV +I P + +++V T ++SC P I
Sbjct: 391 ICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTI 450
Query: 542 ILKKK---AETGDTVLKSID-GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
+ +K T D+ +K ++ G IR A+L D G Y C + G S ++VQ
Sbjct: 451 LWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 86.7 bits (213), Expect = 6e-17
Identities = 99/420 (23%), Positives = 174/420 (41%), Gaps = 91/420 (21%)
Query: 244 MTCSSEGLPAPEIFW---------SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGV 294
+ C + G P P I W SK+ N +Q L N TL++ + ++D G Y+C
Sbjct: 1668 LPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLP-NGTLSIQRVEIQDRGQYLCSAS 1726
Query: 295 NLIGKNRKEVELIVQAFP------RDPEIEMSGGLVNGSSVTVSCKV-----PSVYPLDR 343
NL G + V L V ++P R EI + +GS+V + C+ P+V
Sbjct: 1727 NLFGTDHLHVTLSVVSYPPRILERRTKEITVH----SGSTVELKCRAEGRPSPTV----- 1777
Query: 344 LEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEF- 402
+L +T++ E+ + T++ T + L I D F
Sbjct: 1778 --TWILANQTVVS-------------ESSQGSRQAVVTVDGT----LVLHNLSIYDRGFY 1818
Query: 403 --EPKQRQSTQTLYVNVAPRDTTVLVSPSSILEE---------GSSVNMTCLSQGFPAPK 451
+L V + V+ +P ILE+ G S+ + C ++G P P
Sbjct: 1819 KCVASNPGGQDSLLVKI-----QVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPS 1873
Query: 452 ILWSRQLPNG-ELQPLS---------ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVE 501
+ W L +G E++PL N TL + + D G Y C + G R+ V
Sbjct: 1874 VYW--VLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVM 1931
Query: 502 LIIQ--VTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWI--------ILKKKAETGD 551
L ++ VT I+ + V GD ++++C+ P+ I ++ ++ G
Sbjct: 1932 LTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGS 1991
Query: 552 TVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ---GRENNKDYFSPELL 608
+ +G+ I KD+GVY C ++NK+G L + + ++ + ++K YF ++L
Sbjct: 1992 WIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVL 2051
Score = 84.7 bits (208), Expect = 2e-16
Identities = 136/610 (22%), Positives = 233/610 (38%), Gaps = 96/610 (15%)
Query: 40 GDSVSLTCSTTGCESPFFSWR----TQIDSPLNGKVTNEGT-------TSTLTMNPVSFG 88
G + C +G P SW T I++ + + T TL N V
Sbjct: 2053 GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVA 2112
Query: 89 NEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGP----LEAGKPITVKCSVA-DVY 143
E Y C A K E + + + + P I S ++AG + C V D
Sbjct: 2113 EEGDYTCYAQNTLGKDEMKVHLTVITAA--PRIRQSNKTNKRIKAGDTAVLDCEVTGDPK 2170
Query: 144 PFDRLEIDLLKGDHLMKSQEFLE-DADRKSLETK-SLEVTFTPVIEDIGKVLVCRAKLHI 201
P K L+ S + + DR + SL + +++ V V R
Sbjct: 2171 P---------KIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNP--- 2218
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK 261
D + V I+ T +V +T ++ C +EG P+PE+ W
Sbjct: 2219 -SGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKK-HFDCRAEGTPSPEVMWIMP 2276
Query: 262 LDN--------GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR 313
DN G+ + N TL + +R+ DS ++C N G++ V+L V R
Sbjct: 2277 -DNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLR 2335
Query: 314 DPEIE--MSGGLVN--GSSVTVSCKVPSVYPLDRLEIELLKGETILEN----IEFLEDTD 365
P + +V G S ++C V P + + I L T N ++L ++
Sbjct: 2336 RPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWI--LPNGTRFSNGPQSYQYLIASN 2393
Query: 366 MKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVL 425
+ +K+ T ED GK C A+ + +E + + + + + +
Sbjct: 2394 GSFIISKT-------TREDAGKYR-CAARNKVGYIE---------KLVILEIGQKPVILT 2436
Query: 426 VSPSSILE-EGSSVNMTCLSQGFPAPKILWSRQLPNGELQP---------LSENATLTLI 475
+P ++ G S+++ C+S G P P I W+ +P+G + L +N TL +
Sbjct: 2437 YAPGTVKGISGESLSLHCVSDGIPKPNIKWT--MPSGYVVDRPQINGKYILHDNGTLVIK 2494
Query: 476 STKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESV--KEGDTVIISCTC 533
D G Y+C+ N G + V ++I P ++T P S+ + G + C
Sbjct: 2495 EATAYDRGNYICKAQNSVGHTLITVPVMIVAYPP--RITNRPPRSIVTRTGAAFQLHCVA 2552
Query: 534 GNVPE---TW-------IILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVG 583
VP+ TW + K T + + G I+ Q D+G+Y+C +KN +G
Sbjct: 2553 LGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
Query: 584 SQLRSLTLDV 593
S + + V
Sbjct: 2613 SDYAATYIQV 2622
Score = 80.1 bits (196), Expect = 6e-15
Identities = 132/619 (21%), Positives = 229/619 (36%), Gaps = 102/619 (16%)
Query: 26 KIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLN-----GKVTNEGTTSTL 80
+IE + R GD + L CS TG P WR + ++ G + +L
Sbjct: 1942 RIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSL 2001
Query: 81 TMNPVSFGNEHSYLCTATCE--SRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCS 138
+ V+ + YLC A + + + + + D + + + GK V C
Sbjct: 2002 FIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCK 2061
Query: 139 VADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLET----KSLEVTFTPVIEDIGKVLV 194
A P + L G + + + + R T +L V E+
Sbjct: 2062 -ASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCY 2120
Query: 195 CRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAP 254
+ L DEM TV A ++ S + +++ G + + C G P P
Sbjct: 2121 AQNTLGKDEMKVHLTVITAAPRIRQ---------SNKTNKRIKAGDTAVLDCEVTGDPKP 2171
Query: 255 EIFW---SKKLDNGNLQHLS--GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVEL-IV 308
+IFW S + + ++ + N +LT+ +++ DSG YVC N G + K +L +V
Sbjct: 2172 KIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVV 2231
Query: 309 QAFPRDPEIEMSGGLVNGSSVTVSCK--------VPS-------------VYPLDRLEIE 347
P + + ++ ++V S K PS P I
Sbjct: 2232 SKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRIT 2291
Query: 348 LLKGETI-LENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQ 406
+ K T+ + N+ + D FI + G V +L + +M P
Sbjct: 2292 VHKNGTLEIRNVRLSDSAD------------FICVARNEGGESVLVVQLEVLEMLRRPTF 2339
Query: 407 RQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGE---- 462
R + + + G S + C G P P+I+W LPNG
Sbjct: 2340 RNP----------------FNEKIVAQLGKSTALNCSVDGNPPPEIIWI--LPNGTRFSN 2381
Query: 463 -----LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFP 517
++ N + + T ED+G Y C N+ G K V I+++ K + LT P
Sbjct: 2382 GPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLV--ILEIGQKPVILTYAP 2439
Query: 518 SESVK--EGDTVIISCTCGNVPETWI--------ILKKKAETGDTVLKSIDGAYTIRKAQ 567
+VK G+++ + C +P+ I ++ + G +L +G I++A
Sbjct: 2440 G-TVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHD-NGTLVIKEAT 2497
Query: 568 LKDAGVYECESKNKVGSQL 586
D G Y C+++N VG L
Sbjct: 2498 AYDRGNYICKAQNSVGHTL 2516
Score = 77.0 bits (188), Expect = 5e-14
Identities = 92/401 (22%), Positives = 161/401 (40%), Gaps = 62/401 (15%)
Query: 234 TKLQEGGSVTMTCSSEGLPAPEIFW---SKKLDN-----GNLQHLSGNATLTLIAMRMED 285
T++ G + + CS+ G P P+I W SK + + G+ H+ N +L + ++ +D
Sbjct: 1951 TEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKD 2010
Query: 286 SGIYVCEGVNLIGKNR--KEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDR 343
SG+Y+C N +G + V L ++ D + +++G V CK S P+
Sbjct: 2011 SGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKA-SGSPVPE 2069
Query: 344 LEIELLKGETILENIEFLEDTDMKS-----LENKSLEMTFIPTIEDTGKALVCQAKLHID 398
+ L G T++ N +D+ ++ N +L + E+ Q L D
Sbjct: 2070 ISWSLPDG-TMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKD 2128
Query: 399 DMEFE-------PKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPK 451
+M+ P+ RQS +T + ++ G + + C G P PK
Sbjct: 2129 EMKVHLTVITAAPRIRQSNKT----------------NKRIKAGDTAVLDCEVTGDPKPK 2172
Query: 452 ILWSRQLPNGELQPLS-------ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII 504
I W LP+ ++ S N +LT+ K+ DSG Y+C N +G K +L +
Sbjct: 2173 IFWL--LPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
Query: 505 QVTPKDI-----KLTAFPSESVKEGDTVIISCTCGNVPE---TWI----ILKKKAETGDT 552
P I T + +V+ C P WI I G
Sbjct: 2231 VSKPPLINGLYTNRTVIKATAVRHSKK-HFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSR 2289
Query: 553 VLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
+ +G IR +L D+ + C ++N+ G + + L+V
Sbjct: 2290 ITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEV 2330
Score = 60.1 bits (144), Expect = 6e-09
Identities = 117/538 (21%), Positives = 201/538 (37%), Gaps = 102/538 (18%)
Query: 9 LGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLN 68
LG + + + A +I + ++ + GD+ L C TG P W + ++
Sbjct: 2125 LGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMIS 2184
Query: 69 GKVTNE--GTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGP 126
+ +LT+N V + Y+C A S K ++++ S P L
Sbjct: 2185 FSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPP-----LING 2239
Query: 127 LEAGKPITVKCSVA-DVYPFD-------RLEIDLLKGDHLMKSQEF----LEDADRKSLE 174
L + + +V FD E+ + D++ + + + +LE
Sbjct: 2240 LYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLE 2299
Query: 175 TKSLEVT----FTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISV 230
+++ ++ F V + G V +L + EM PT R E V
Sbjct: 2300 IRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIV----------- 2348
Query: 231 NPSTKLQEGGSVTMTCSSEGLPAPEIFW----SKKLDNGNLQH---LSGNATLTLIAMRM 283
Q G S + CS +G P PEI W + NG + ++ N + +
Sbjct: 2349 -----AQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTR 2403
Query: 284 EDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLV---NGSSVTVSC------- 333
ED+G Y C N +G K V I++ + + + G V +G S+++ C
Sbjct: 2404 EDAGKYRCAARNKVGYIEKLV--ILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPK 2461
Query: 334 -----KVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA 388
+PS Y +DR +I G+ IL D +L K T D G
Sbjct: 2462 PNIKWTMPSGYVVDRPQI---NGKYILH--------DNGTLVIKE------ATAYDRGN- 2503
Query: 389 LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSIL-EEGSSVNMTCLSQGF 447
+C+A+ + + + V PR T P SI+ G++ + C++ G
Sbjct: 2504 YICKAQNSVGHTLI------TVPVMIVAYPPRITN--RPPRSIVTRTGAAFQLHCVALGV 2555
Query: 448 PAPKILW-----------SRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAG 494
P P+I W S++ +G Q L TL + + + DSG+Y C N G
Sbjct: 2556 PKPEITWEMPDHSLLSTASKERTHGSEQ-LHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
Score = 58.2 bits (139), Expect = 2e-08
Identities = 46/183 (25%), Positives = 74/183 (40%), Gaps = 20/183 (10%)
Query: 429 SSILEEGSSVNMTCLSQGFPAPKILWSR---------QLPNGELQPLSENATLTLISTKM 479
S + S + C + G P P I W+R + N +Q L N TL++ ++
Sbjct: 1657 SFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLP-NGTLSIQRVEI 1715
Query: 480 EDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE- 538
+D G YLC N G V L + P I +V G TV + C P
Sbjct: 1716 QDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSP 1775
Query: 539 --TWI-----ILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTL 591
TWI ++ + ++ + ++DG + + D G Y+C + N G SL +
Sbjct: 1776 TVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQD--SLLV 1833
Query: 592 DVQ 594
+Q
Sbjct: 1834 KIQ 1836
Score = 54.7 bits (130), Expect = 3e-07
Identities = 83/414 (20%), Positives = 160/414 (38%), Gaps = 71/414 (17%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFW--------SKKLDNGNLQHLSGNATLTLIAMRMEDSG 287
+ G +V + C +EG P+P + W S+ ++ + TL L + + D G
Sbjct: 1757 VHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRG 1816
Query: 288 IYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVN--GSSVTVSCKV-----PSVYP 340
Y C N G++ V++ V A P + +V G S+ + C PSVY
Sbjct: 1817 FYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYW 1876
Query: 341 L--DRLEIELLK---GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKL 395
+ D E++ L+ + L + L ++ S + + E + + ++ +
Sbjct: 1877 VLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEE 1936
Query: 396 HIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWS 455
+ E ++ T+ + G + + C + G P P+I+W
Sbjct: 1937 RVTSPRIEAASQKRTEVNF--------------------GDKLLLNCSATGEPKPQIMW- 1975
Query: 456 RQLPN----------GELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 505
+LP+ G + N +L + S +DSGVYLC N+ G + + ++
Sbjct: 1976 -RLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLR 2034
Query: 506 VTPKDIKLTAFPSESVKEGDTVIISCTCGN--VPE-TW-----IILKKKAETGDTVLKS- 556
+ P I + + V G + C VPE +W ++ + D+ ++
Sbjct: 2035 LKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTR 2094
Query: 557 -----IDGAYTIRKAQLKDAGVYECESKNKVGS-----QLRSLTLDVQGRENNK 600
+G K + + G Y C ++N +G L +T + R++NK
Sbjct: 2095 RYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNK 2148
Score = 38.1 bits (87), Expect = 0.025
Identities = 49/209 (23%), Positives = 83/209 (39%), Gaps = 30/209 (14%)
Query: 393 AKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKI 452
A++ + E P + + T N + TVLV G +V + C QG P P +
Sbjct: 456 AQITLPRAEMRPVKHKWTMISRDNNTKLEHTVLV--------GGTVGLNCPGQGDPTPHV 507
Query: 453 LWSRQLPNGELQP-LSENATLTL-ISTKME-------DSGVYLCEGINQAGRSRKEVELI 503
W + P +SE+ + + S K+E D+GVY C N L
Sbjct: 508 DWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDAD----ILT 563
Query: 504 IQVTPKDIKLTAFPSESVKE----GDTVIISCTCGNVPE---TWIILKKKAETGDTVLKS 556
++T + + A+ + G+T+ + C +P+ +W+I + K
Sbjct: 564 YRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKK 623
Query: 557 IDGAYTIRKAQL--KDAGVYECESKNKVG 583
+ T+R Q+ KD G Y C + N G
Sbjct: 624 VLNNGTLRILQVTPKDQGYYRCVAANPSG 652
Score = 30.8 bits (68), Expect = 4.1
Identities = 15/42 (35%), Positives = 24/42 (57%), Gaps = 4/42 (9%)
Query: 221 ISPKNTVISVNPSTKLQE----GGSVTMTCSSEGLPAPEIFW 258
+ K T+IS + +TKL+ GG+V + C +G P P + W
Sbjct: 468 VKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDW 509
>gi|11225258 myelin associated glycoprotein isoform a precursor
[Homo sapiens]
Length = 626
Score = 85.5 bits (210), Expect = 1e-16
Identities = 91/342 (26%), Positives = 147/342 (42%), Gaps = 28/342 (8%)
Query: 273 NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQAFPRDPEIEMSGGLVNGSSVTV 331
N TL L + E G Y G +L G N+ E V P I + +V G+ V V
Sbjct: 99 NCTLLLSNVSPELGGKYYFRG-DLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEV 157
Query: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC 391
SC VP P R E+ L E + E + + + + F+PT E G L C
Sbjct: 158 SCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGC 217
Query: 392 QAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE--EGSSVNMTCLSQGFPA 449
QA ++FE Y ++ + V+V +S +E EGS V++ C + P
Sbjct: 218 QASFPNTTLQFEG---------YASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268
Query: 450 PKILWSRQLPNGEL--QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVT 507
P + W R +G + + ++E+ L L + GVY C N G+ + V L +
Sbjct: 269 PLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYA 325
Query: 508 PKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQ 567
P K T + EG+TV I C+ + P+ + + K+ + TV+ + +
Sbjct: 326 PW--KPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVS 383
Query: 568 LKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLV 609
+D G Y C ++N+ G + + L V+ F+P LL+
Sbjct: 384 PEDDGEYWCVAENQYGQRATAFNLSVE--------FAPVLLL 417
Score = 54.7 bits (130), Expect = 3e-07
Identities = 111/506 (21%), Positives = 197/506 (38%), Gaps = 61/506 (12%)
Query: 119 PEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSL 178
P I + + AG + V C V D P R E+ L + L + + + +
Sbjct: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS 200
Query: 179 EVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQE 238
+ F P E G L C+A + VK V ++ +N S + E
Sbjct: 201 LLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV-------IVEMNSSVEAIE 253
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNL--QHLSGNATLTLIAMRMEDSGIYVCEGVNL 296
G V++ C ++ P P + W + +G + + ++ + L L + + G+Y C N
Sbjct: 254 GSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENA 310
Query: 297 IGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPS-VYPLDRLEIELLKGETIL 355
G++ + V L V P P + + V G +V++ C S P+ + + K + IL
Sbjct: 311 YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPI----LTIFKEKQIL 366
Query: 356 ENIEFLEDTDMKSLENKSLEMTFIPTI--EDTGKALVCQAKLHIDDMEFEPKQRQSTQTL 413
+ + + ++ +P + ED G+ C A E + QR + L
Sbjct: 367 STVIYESELQLE-----------LPAVSPEDDGE-YWCVA-------ENQYGQRATAFNL 407
Query: 414 YVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKI---LWSRQLPNGELQ---PLS 467
V AP VL+ S +V C+ + P P + L SR + E + S
Sbjct: 408 SVEFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYS 463
Query: 468 ENATLTLIST-----KMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVK 522
E + L L S + + +C N G K +EL Q + + P +V
Sbjct: 464 ERSGLVLTSILTLRGQAQAPPRVICTARNLYG--AKSLELPFQGAHRLMWAKIGPVGAV- 520
Query: 523 EGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYE-CESKNK 581
++I+ C + +T +KK T + D + + + +G E ES+ +
Sbjct: 521 VAFAILIAIVC-YITQT---RRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERR 576
Query: 582 VGSQLRSLTLDVQGRENNKDYFSPEL 607
+GS+ R L L + E + Y +L
Sbjct: 577 LGSERRLLGLRGEPPELDLSYSHSDL 602
>gi|18104957 myelin associated glycoprotein isoform b precursor
[Homo sapiens]
Length = 582
Score = 85.5 bits (210), Expect = 1e-16
Identities = 91/342 (26%), Positives = 147/342 (42%), Gaps = 28/342 (8%)
Query: 273 NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQAFPRDPEIEMSGGLVNGSSVTV 331
N TL L + E G Y G +L G N+ E V P I + +V G+ V V
Sbjct: 99 NCTLLLSNVSPELGGKYYFRG-DLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEV 157
Query: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC 391
SC VP P R E+ L E + E + + + + F+PT E G L C
Sbjct: 158 SCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGC 217
Query: 392 QAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE--EGSSVNMTCLSQGFPA 449
QA ++FE Y ++ + V+V +S +E EGS V++ C + P
Sbjct: 218 QASFPNTTLQFEG---------YASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268
Query: 450 PKILWSRQLPNGEL--QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVT 507
P + W R +G + + ++E+ L L + GVY C N G+ + V L +
Sbjct: 269 PLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYA 325
Query: 508 PKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQ 567
P K T + EG+TV I C+ + P+ + + K+ + TV+ + +
Sbjct: 326 PW--KPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVS 383
Query: 568 LKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLV 609
+D G Y C ++N+ G + + L V+ F+P LL+
Sbjct: 384 PEDDGEYWCVAENQYGQRATAFNLSVE--------FAPVLLL 417
Score = 54.3 bits (129), Expect = 3e-07
Identities = 76/347 (21%), Positives = 137/347 (39%), Gaps = 44/347 (12%)
Query: 119 PEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSL 178
P I + + AG + V C V D P R E+ L + L + + + +
Sbjct: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS 200
Query: 179 EVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQE 238
+ F P E G L C+A + VK V ++ +N S + E
Sbjct: 201 LLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV-------IVEMNSSVEAIE 253
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNL--QHLSGNATLTLIAMRMEDSGIYVCEGVNL 296
G V++ C ++ P P + W + +G + + ++ + L L + + G+Y C N
Sbjct: 254 GSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENA 310
Query: 297 IGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPS-VYPLDRLEIELLKGETIL 355
G++ + V L V P P + + V G +V++ C S P+ + + K + IL
Sbjct: 311 YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPI----LTIFKEKQIL 366
Query: 356 ENIEFLEDTDMKSLENKSLEMTFIPTI--EDTGKALVCQAKLHIDDMEFEPKQRQSTQTL 413
+ + + ++ +P + ED G+ C A E + QR + L
Sbjct: 367 STVIYESELQLE-----------LPAVSPEDDGE-YWCVA-------ENQYGQRATAFNL 407
Query: 414 YVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPN 460
V AP VL+ S +V C+ + P P + + +LP+
Sbjct: 408 SVEFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAF--ELPS 448
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 84.3 bits (207), Expect = 3e-16
Identities = 131/536 (24%), Positives = 210/536 (39%), Gaps = 70/536 (13%)
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-GKPITVKCSVADVYPFDRLE 149
H YL C L G ++ FP H S + + G+P T+ C A+ P +E
Sbjct: 7 HFYLFGLIC----LCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK-AEGRPTPTIE 61
Query: 150 IDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIE------DIGKVLVCRAKLHIDE 203
KG +++ + + R L + SL F ++ D G V VC A+ ++ E
Sbjct: 62 --WYKGGERVETDKDDPRSHRMLLPSGSL--FFLRIVHGRKSRPDEG-VYVCVARNYLGE 116
Query: 204 MDSV-PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS-EGLPAPEIFWSKK 261
S ++ A+ +P + +++V G M C G P P I W K
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAV--------GEPAVMECQPPRGHPEPTISWKKD 168
Query: 262 ---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQAFPRDPEI 317
LD+ + + L + R D+G YVC G N++G+ EV EL V P +
Sbjct: 169 GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKR 228
Query: 318 EMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMT 377
+ + S C+ P+ + GE E +D +K +
Sbjct: 229 PSNLAVTVDDSAEFKCEARG-DPVPTVRWRKDDGELPKSRYEIRDDHTLKIRK------- 280
Query: 378 FIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSS 437
T D G + C A+ + E +V V PRD V + G +
Sbjct: 281 --VTAGDMG-SYTCVAENMVGKAEASATLTVQEPPHFV-VKPRDQVVAL--------GRT 328
Query: 438 VNMTCLSQGFPAPKILWSRQLPNGEL---QP--------LSENATLTLISTKMEDSGVYL 486
V C + G P P I W R+ L QP +S+ LT+ + + D G Y+
Sbjct: 329 VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI 388
Query: 487 CEGINQAG----RSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWII 542
C+ +N AG ++ EV +I P + +++V T ++SC P I+
Sbjct: 389 CQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTIL 448
Query: 543 LKKK---AETGDTVLKSID-GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
+K T D+ +K ++ G IR A+L D G Y C + G S ++VQ
Sbjct: 449 WRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 84.3 bits (207), Expect = 3e-16
Identities = 131/628 (20%), Positives = 231/628 (36%), Gaps = 111/628 (17%)
Query: 27 IETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEG---TTSTLTMN 83
+ PE ++G +V+L C + G W +P + G + + L ++
Sbjct: 3114 VSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQIS 3173
Query: 84 PVSFGNEHSYLCTATCESRKLEKGIQVEIYS---FPKDPEIHLSGP---LEAGKPITVKC 137
+ +Y+C A +K ++V + + P P++ +EAG T++C
Sbjct: 3174 SAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRC 3233
Query: 138 SV----ADVYPFDRLEIDL-----LKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIED 188
S A + +L L L+GD L+ + +D+ +
Sbjct: 3234 SATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQ------------------ 3275
Query: 189 IGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS 248
+C A S +A L V P T + + S +Q G +V + C +
Sbjct: 3276 ----YICNAT-------SPAGHAEATIILHVESPPYATTVPEHAS--VQAGETVQLQCLA 3322
Query: 249 EGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIV 308
G P WS+ + + + N L EDSG Y C N +G +L+V
Sbjct: 3323 HGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLV 3382
Query: 309 QAFPRD-----------PEIEMSGGLVN---GSSVTVSCKVPSVYPLDRLEI----ELLK 350
Q P P ++++ L G+SV C VPS +L
Sbjct: 3383 QGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPP 3442
Query: 351 GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQST 410
G ++ + + +++ D +S + T+I A+L I Q+
Sbjct: 3443 GHSVQDGVLRIQNLD------QSCQGTYICQAHGPWGKAQASAQLVI----------QAL 3486
Query: 411 QTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQP--LSE 468
++ +N+ TV+V G +V CL+ G P P++ WS+ G L+P +
Sbjct: 3487 PSVLINIRTSVQTVVV--------GHAVEFECLALGDPKPQVTWSKV--GGHLRPGIVQS 3536
Query: 469 NATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTV 527
+ + ++ D+G Y C N AG ++ V L++Q P+ + P E V G
Sbjct: 3537 GGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQ----ISMPQEVRVPAGSAA 3592
Query: 528 IISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLR 587
+ C P I K + + + + + +DAG Y C + N+ G
Sbjct: 3593 VFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKA 3652
Query: 588 SLTLDVQGRENNKDYFSPELLVLYFASS 615
L V PE +V YF +
Sbjct: 3653 FAHLQV-----------PERVVPYFTQT 3669
Score = 81.6 bits (200), Expect = 2e-15
Identities = 99/414 (23%), Positives = 163/414 (39%), Gaps = 57/414 (13%)
Query: 210 VRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK------KLD 263
V Q+V L V+ P +V+ P ++ G +VT+ C S G P W++ KL+
Sbjct: 3099 VAQSVVNLSVHGPPTVSVLPEGP-VWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLE 3157
Query: 264 NGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQA---FPRDPEIEMS 320
+ +A L + + + D+G YVC N +G +K+VE+IV P P+++
Sbjct: 3158 QRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAE 3217
Query: 321 GGLVN---GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMT 377
+ G + T+ C P + L+ ++ LE +L
Sbjct: 3218 EAELTVEAGHTATLRCSATG-SPAPTIHWSKLRSPLPWQH----------RLEGDTL--- 3263
Query: 378 FIPTI--EDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEG 435
IP + +D+G+ +C A E +T L+V P TTV S ++ G
Sbjct: 3264 IIPRVAQQDSGQ-YICNATSPAGHAE-------ATIILHVESPPYATTVPEHAS--VQAG 3313
Query: 436 SSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGR 495
+V + CL+ G P WSR + + + N L EDSG Y C N+ G
Sbjct: 3314 ETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGS 3373
Query: 496 SRKEVELIIQVTPKDIKLTAFPS------------ESVKEGDTVIISCTCGNVPET---W 540
+ +L++Q P + T+ P+ E+ G +V C + T W
Sbjct: 3374 AEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRW 3433
Query: 541 IILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
+ G +V DG I+ G Y C++ G S L +Q
Sbjct: 3434 FKEGGQLPPGHSVQ---DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQ 3484
Score = 80.1 bits (196), Expect = 6e-15
Identities = 87/401 (21%), Positives = 169/401 (42%), Gaps = 42/401 (10%)
Query: 223 PKNTVISVNPSTKLQEGGSVTMTCSSEGL-PAPEIFWSKKLDNGNL--QHLSGNATLTLI 279
P + S ++ G VT C+++ PA + W++ L NG L + + N LT+
Sbjct: 1770 PITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTR-LHNGKLPTRAMDFNGILTIR 1828
Query: 280 AMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVY 339
+++ D+G YVC G N+ ++ L VQA G ++ V++ +V
Sbjct: 1829 NVQLSDAGTYVCTGSNMFAMDQGTATLHVQA----------SGTLSAPVVSIHPPQLTVQ 1878
Query: 340 PLDRLEIELLKGETILENIEFLEDTDMKSLENKSLE--MTFIPTIEDTGKA-LVCQAKLH 396
P E + +E+ + + + +P +E T +A +C+A
Sbjct: 1879 PGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRA--- 1935
Query: 397 IDDMEFEPKQRQSTQTLYVNVA--PRDTTVLVSPSSI-LEEGSSVNMTCLSQGFPAPKIL 453
Q+ + L+V+ PR V VSP + G +V + C + G P+ I
Sbjct: 1936 ----HSSAGQQVARAVLHVHGGGGPR---VQVSPERTQVHAGRTVRLYCRAAGVPSATIT 1988
Query: 454 WSRQLPNGELQPLSEN-----ATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII---- 504
W ++ G L P + + ATL + + D+G YLC + AG ++ +++++
Sbjct: 1989 WRKE--GGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSAS 2046
Query: 505 QVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIR 564
+P +K+ + S SV EG T+ ++C + ++ + + +
Sbjct: 2047 DASPPPVKIES-SSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLP 2105
Query: 565 KAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSP 605
+ D+G Y C +N G + S+T+ V ++ ++P
Sbjct: 2106 QVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTP 2146
Score = 73.9 bits (180), Expect = 4e-13
Identities = 88/385 (22%), Positives = 152/385 (39%), Gaps = 56/385 (14%)
Query: 227 VISVNPSTKL-QEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAM 281
V+ V+P+ + +GGS ++ C G P +WS++ + +G Q G+ L ++
Sbjct: 1678 VVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSE-LHFPSV 1736
Query: 282 RMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP-----EIEMSGGLVNGSSVTVSCKVP 336
+ D+G+Y+C NL N EL+V P P E + S + G+ VT C
Sbjct: 1737 QPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAK 1796
Query: 337 SVYPLDRLE-IELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKL 395
S P L L G+ ++F +++++ + D G + + +
Sbjct: 1797 SKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQ-----------LSDAGTYVCTGSNM 1845
Query: 396 HIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVS---PSSILEEGSSVNMTCLSQGFPAPKI 452
D Q T TL+V + + +VS P ++ G C + G P P +
Sbjct: 1846 FAMD--------QGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTL 1897
Query: 453 LWSRQLPNGELQPLSE--NATLTLISTKMEDSGVYLCEGINQAGRSRKEVEL-------- 502
W+ P G+L ++ L L + + D YLC + AG+ L
Sbjct: 1898 EWTGG-PGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGP 1956
Query: 503 IIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSID---G 559
+QV+P+ ++ A G TV + C VP I +K+ + +S
Sbjct: 1957 RVQVSPERTQVHA--------GRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIA 2008
Query: 560 AYTIRKAQLKDAGVYECESKNKVGS 584
I DAG Y C + + G+
Sbjct: 2009 TLLIPAITTADAGFYLCVATSPAGT 2033
Score = 72.8 bits (177), Expect = 9e-13
Identities = 59/190 (31%), Positives = 90/190 (47%), Gaps = 15/190 (7%)
Query: 416 NVAPRDTTVLVSPS-SILEEGSSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENA 470
N AP V V P+ SI+ +G S ++ C G P WSR+ +P+G Q + +
Sbjct: 1673 NQAP--LVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGT-QQRHQGS 1729
Query: 471 TLTLISTKMEDSGVYLC--EGINQAGRSRKEVELIIQVTPKDIKLTAFP--SESVKEGDT 526
L S + D+GVY+C ++Q+ SR E+ L+ + K I +T S+SV+ G
Sbjct: 1730 ELHFPSVQPSDAGVYICTCRNLHQSNTSRAEL-LVTEAPSKPITVTVEEQRSQSVRPGAD 1788
Query: 527 VIISCTCGNVPETWIILKKKAETGDTVLKSID--GAYTIRKAQLKDAGVYECESKNKVGS 584
V CT + + ++ + G +++D G TIR QL DAG Y C N
Sbjct: 1789 VTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAM 1848
Query: 585 QLRSLTLDVQ 594
+ TL VQ
Sbjct: 1849 DQGTATLHVQ 1858
Score = 62.0 bits (149), Expect = 2e-09
Identities = 80/391 (20%), Positives = 154/391 (39%), Gaps = 41/391 (10%)
Query: 228 ISVNPS-TKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGN-----ATLTLIAM 281
+ V+P T++ G +V + C + G+P+ I W K + G+L + + ATL + A+
Sbjct: 1958 VQVSPERTQVHAGRTVRLYCRAAGVPSATITWRK--EGGSLPPQARSERTDIATLLIPAI 2015
Query: 282 RMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPL 341
D+G Y+C + G + ++++V +S + V + PSV
Sbjct: 2016 TTADAGFYLCVATSPAGTAQARIQVVV----------LSASDASPPPVKIESSSPSVTEG 2065
Query: 342 DRLEIE-LLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIE--DTGKALVCQAKLHID 398
L++ ++ G + + + +P + D+G+ VC+
Sbjct: 2066 QTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGE-YVCRV----- 2119
Query: 399 DMEFEPKQRQSTQTL---------YVNVAPRDTTVLVSPSSI-LEEGSSVNMTCLSQGFP 448
+ PK+ T ++ Y V + + PSS + EG ++++ C+ G
Sbjct: 2120 ENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQA 2179
Query: 449 APKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ--V 506
++ W ++ + + + + L L DSG Y+C + +G V + I+ V
Sbjct: 2180 HAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASV 2239
Query: 507 TPKDIKLTAFPSES--VKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIR 564
P I S S V EG T+ +SC + K+ + + I
Sbjct: 2240 IPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIF 2299
Query: 565 KAQLKDAGVYECESKNKVGSQLRSLTLDVQG 595
+A DAG Y C + N + + + QG
Sbjct: 2300 QASPADAGQYVCRASNGMEASITVTVTGTQG 2330
Score = 57.8 bits (138), Expect = 3e-08
Identities = 121/598 (20%), Positives = 221/598 (36%), Gaps = 58/598 (9%)
Query: 26 KIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTT-STLTMNP 84
+++ +PE R G +V L C G S +WR + S L + +E T +TL +
Sbjct: 1957 RVQVSPE-RTQVHAGRTVRLYCRAAGVPSATITWRKEGGS-LPPQARSERTDIATLLIPA 2014
Query: 85 VSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYP 144
++ + YLC AT + + IQV + LS + P+ ++ S V
Sbjct: 2015 ITTADAGFYLCVATSPAGTAQARIQVVV----------LSASDASPPPVKIESSSPSVTE 2064
Query: 145 FDRLEIDLLKGDHLMKSQEFLEDADRKSLETK--SLEVTFTPVIEDIGKVLVCRAKLHID 202
L+++ + + T+ + V VCR +
Sbjct: 2065 GQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSG 2124
Query: 203 EMDSVPTVR--QAVKELQVY--ISPKNTVISVNPSTK-LQEGGSVTMTCSSEGLPAPEIF 257
++ TV Y + I + PS+ + EG ++ + C G ++
Sbjct: 2125 PKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVT 2184
Query: 258 WSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAF----PR 313
W K+ + +H + + L L + DSG YVC V G V + ++A P
Sbjct: 2185 WHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPI 2244
Query: 314 DP-EIEMSGGLV-NGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLEN 371
P IE S V G ++ +SC V G+ + + + +
Sbjct: 2245 PPVRIESSSSTVAEGQTLDLSCVVA--------------GQAHAQVTWYKRGGSLPARHQ 2290
Query: 372 KSLEMTFI--PTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVA-PRDTT--VLV 426
+I + D G+ VC+A + ME T T N+A P +T + +
Sbjct: 2291 VRGSRLYIFQASPADAGQ-YVCRAS---NGMEASITVTV-TGTQGANLAYPAGSTQPIRI 2345
Query: 427 SPSSI-LEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVY 485
PSS + EG ++++ C+ G ++ W ++ + ++ + + L L DSG Y
Sbjct: 2346 EPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEY 2405
Query: 486 LCEGINQAGRSRKEVELIIQVTPKDIKLTAFP-------SESVKEGDTVIISCTCGNVPE 538
+C + + V + I+ L P S V EG T+ ++C
Sbjct: 2406 VCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAH 2465
Query: 539 TWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGR 596
+ K+ + + + + D+G Y C G+Q S+ + +Q R
Sbjct: 2466 AQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQR 2523
Score = 56.6 bits (135), Expect = 7e-08
Identities = 81/397 (20%), Positives = 151/397 (38%), Gaps = 30/397 (7%)
Query: 216 ELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNAT 275
E V P V + S+ + EG ++ ++C G ++ W K+ + +H +
Sbjct: 2236 EASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSR 2295
Query: 276 LTLIAMRMEDSGIYVCEGVN-------LIGKNRKEVELIVQAFPRDP-EIEMSGGLV-NG 326
L + D+G YVC N + + L A P IE S V G
Sbjct: 2296 LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEG 2355
Query: 327 SSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTG 386
++ ++C VP ++ K L ++ + SL + + D+G
Sbjct: 2356 QTLDLNCVVPGQ---SHAQVTWHKRGGSLP---------VRHQTHGSLLRLYQASPADSG 2403
Query: 387 KALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQG 446
+ VC+ +E + T + S SS + EG ++++ CL G
Sbjct: 2404 E-YVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAG 2462
Query: 447 FPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ- 505
++ W ++ + + + L L+ DSG Y+C + +G V + IQ
Sbjct: 2463 QAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQ 2522
Query: 506 -VTPKDIKLTAFP------SESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSID 558
++ + A+P S S+ G T+ ++C + I K+ + + + +
Sbjct: 2523 RLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVG 2582
Query: 559 GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQG 595
I + D+G Y C N GS+ SL + +QG
Sbjct: 2583 SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQG 2619
Score = 53.5 bits (127), Expect = 6e-07
Identities = 91/400 (22%), Positives = 151/400 (37%), Gaps = 60/400 (15%)
Query: 228 ISVNPST-KLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDS 286
I + PS+ ++ EG ++ + C G ++ W K+ N +H L L + DS
Sbjct: 2829 IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADS 2888
Query: 287 GIYVCEGVNLIGKNRKEVELIVQAFPRDPE------------IEMSGGLVN-GSSVTVSC 333
G Y C+ G E ++V P P IE S V G ++ ++C
Sbjct: 2889 GEYSCQVTGSSGT--LEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNC 2946
Query: 334 KVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQA 393
VP ++ K L + ++ + + D+G+ VC+A
Sbjct: 2947 VVPGQA---HAQVTWYKRGGSLPARHQTHGSQLR---------LHLVSPADSGE-YVCRA 2993
Query: 394 KLHIDDMEFEPKQRQSTQTLYVNVAP--------RDTTVLVSP-SSILEEGSSVNMTCLS 444
P+Q S V V P R + + P SS +++G + CL
Sbjct: 2994 ASGPG-----PEQEAS---FTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLI 3045
Query: 445 QGFPAP-KILWSRQLPNGELQP---LSENAT-LTLISTKMEDSGVYLCEGINQAGRSRKE 499
AP + W + N EL+ +S N + +T++ T+ + G Y C N G ++
Sbjct: 3046 HDGAAPISLEWKTR--NQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSV 3103
Query: 500 VELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPET---WIILKK---KAETGDTV 553
V L + P L P VK G V + C P + W + K E
Sbjct: 3104 VNLSVHGPPTVSVLPEGP-VWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYG 3162
Query: 554 LKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
L I A+ DAG Y C ++N +G+ + + + V
Sbjct: 3163 LMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIV 3202
Score = 50.1 bits (118), Expect = 6e-06
Identities = 90/444 (20%), Positives = 162/444 (36%), Gaps = 70/444 (15%)
Query: 194 VCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTK-LQEGGSVTMTCSSEGLP 252
VCRA +ID +++ + + + I + S+ + EG ++ + C G
Sbjct: 2695 VCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQA 2754
Query: 253 APEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFP 312
++ W K+ + H + + L L + DSG YVC + G V + ++A
Sbjct: 2755 HAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEA-- 2812
Query: 313 RDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLE---IELLKGETILENIEFLEDTDMKSL 369
+GSS V P P R+E + +G+T+ D+K +
Sbjct: 2813 ------------SGSS-AVHVPAPGGAPPIRIEPSSSRVAEGQTL----------DLKCV 2849
Query: 370 ENKSLEMTFIPTIEDTGKALVCQAKLH-----------IDDMEFEPKQRQSTQTL----Y 414
T G L + ++H D E+ + S+ TL
Sbjct: 2850 VPGQAHAQV--TWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVL 2907
Query: 415 VNVAPRDTTVLVSP-----------SSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL 463
V + P + +P SS + EG ++++ C+ G ++ W ++ +
Sbjct: 2908 VTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA 2967
Query: 464 QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKD---------IKLT 514
+ + + L L DSG Y+C + G +E + V P + +
Sbjct: 2968 RHQTHGSQLRLHLVSPADSGEYVCRAASGPG-PEQEASFTVTVPPSEGSSYRLRSPVISI 3026
Query: 515 AFPSESVKEGDTVIISCTC--GNVPETWIILKKKAETGDTVLKSIDGA-YTIRKAQLKDA 571
PS +V++G C G P + + E D V S +G+ TI + +
Sbjct: 3027 DPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNH 3086
Query: 572 GVYECESKNKVGSQLRSLTLDVQG 595
G Y C + N G + L V G
Sbjct: 3087 GTYRCVASNAYGVAQSVVNLSVHG 3110
Score = 47.4 bits (111), Expect = 4e-05
Identities = 78/399 (19%), Positives = 144/399 (36%), Gaps = 66/399 (16%)
Query: 233 STKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCE 292
S L G ++ + C I W K+ + +H + L + + DSG YVC
Sbjct: 2542 SASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCH 2601
Query: 293 GVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIE---LL 349
N G +E LIV I+ SG S VPSV P R+E ++
Sbjct: 2602 VSN--GAGSRETSLIV-------TIQGSG----------SSHVPSVSPPIRIESSSPTVV 2642
Query: 350 KGETILENIEFLEDTD-------------MKSLENKSLEMTFIPTIEDTGKALVCQAKLH 396
+G+T+ N + + S ++ D+G+ VC+A +
Sbjct: 2643 EGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGE-YVCRANNN 2701
Query: 397 IDDMEFEPKQRQSTQTLYVNVAPRDTTV----------LVSPSSILEEGSSVNMTCLSQG 446
ID +E ++ ++V+P + + S SS + EG ++++ C+ G
Sbjct: 2702 IDALE---------ASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPG 2752
Query: 447 FPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQV 506
++ W ++ + + + L L DSG Y+C + +G V + I+
Sbjct: 2753 QAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEA 2812
Query: 507 TPKDIKLTAFP-----------SESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLK 555
+ P S V EG T+ + C + K+ +
Sbjct: 2813 SGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQ 2872
Query: 556 SIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
+ + D+G Y C+ G+ S+ + ++
Sbjct: 2873 VHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIE 2911
Score = 46.2 bits (108), Expect = 9e-05
Identities = 46/202 (22%), Positives = 79/202 (39%), Gaps = 22/202 (10%)
Query: 419 PRDTTVLVSPSSILEEGSSVNMTCLSQG-FPAPKILWSRQLPNGEL--QPLSENATLTLI 475
P TV S + G+ V C ++ PA ++W+R L NG+L + + N LT+
Sbjct: 1770 PITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTR-LHNGKLPTRAMDFNGILTIR 1828
Query: 476 STKMEDSGVYLCEGINQAGRSRKEVELIIQVT---PKDIKLTAFPSESVKEGDTVIISCT 532
+ ++ D+G Y+C G N + L +Q + + P +V+ G C+
Sbjct: 1829 NVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCS 1888
Query: 533 CGNVPETWII--------LKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGS 584
P + L KA+ +L+ + + D Y C + + G
Sbjct: 1889 ATGSPTPTLEWTGGPGGQLPAKAQIHGGILR-------LPAVEPTDQAQYLCRAHSSAGQ 1941
Query: 585 QLRSLTLDVQGRENNKDYFSPE 606
Q+ L V G + SPE
Sbjct: 1942 QVARAVLHVHGGGGPRVQVSPE 1963
Score = 43.5 bits (101), Expect = 6e-04
Identities = 76/401 (18%), Positives = 149/401 (37%), Gaps = 35/401 (8%)
Query: 221 ISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIA 280
+SP + S +P+ + EG ++ + C P I W K+ + +H + + L L
Sbjct: 2628 VSPPIRIESSSPT--VVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQ 2685
Query: 281 MRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYP 340
M + DSG YVC N I + E +++ P GSS+ + + S +
Sbjct: 2686 MSVADSGEYVCRANNNI--DALEASIVISVSP-----SAGSPSAPGSSMPIRIESSSSHV 2738
Query: 341 LDRLEIEL---LKGETILENIEFLEDTDMKS---LENKSLEMTFIPTIEDTGKALVCQAK 394
+ ++L + G+ + + S L + + + D+G+ VC+
Sbjct: 2739 AEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHV-SPADSGE-YVCRVM 2796
Query: 395 LHIDDME---FEPKQRQSTQTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTCLSQGFPAP 450
+E + + ++V + + PSS + EG ++++ C+ G
Sbjct: 2797 GSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHA 2856
Query: 451 KILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKD 510
++ W ++ N + L L DSG Y C+ +G E +++ + P
Sbjct: 2857 QVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSG--TLEASVLVTIEPSS 2914
Query: 511 IKLTAFP-----------SESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDG 559
P S V EG T+ ++C + K+ + ++
Sbjct: 2915 PGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGS 2974
Query: 560 AYTIRKAQLKDAGVYECESKNKVG-SQLRSLTLDVQGRENN 599
+ D+G Y C + + G Q S T+ V E +
Sbjct: 2975 QLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGS 3015
Score = 40.4 bits (93), Expect = 0.005
Identities = 30/110 (27%), Positives = 44/110 (40%), Gaps = 15/110 (13%)
Query: 197 AKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEI 256
A H DE P + + P V S + G +VT TC + G+P P I
Sbjct: 384 ASFHCDEESDCPD-----RSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPII 438
Query: 257 FWSKKLDNGNL--------QHLSGNATLTLIAMRMEDSGIYVCEGVNLIG 298
W +L+ G++ G TL + ++ D G Y CE +N G
Sbjct: 439 NW--RLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
Score = 40.0 bits (92), Expect = 0.007
Identities = 23/75 (30%), Positives = 34/75 (45%), Gaps = 3/75 (4%)
Query: 26 KIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRT---QIDSPLNGKVTNEGTTSTLTM 82
++ T P A G +V+ TC G +P +WR I S VT+EG TL +
Sbjct: 407 QVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLII 466
Query: 83 NPVSFGNEHSYLCTA 97
V ++ +Y C A
Sbjct: 467 RDVKESDQGAYTCEA 481
Score = 35.8 bits (81), Expect = 0.13
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 6/81 (7%)
Query: 435 GSSVNMTCLSQGFPAPKILWSRQLPNGELQP----LSENATLTLI--STKMEDSGVYLCE 488
G +V TC++ G P P I W + P SE TLI K D G Y CE
Sbjct: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
Query: 489 GINQAGRSRKEVELIIQVTPK 509
+N G + ++++ P+
Sbjct: 481 AMNARGMVFGIPDGVLELVPQ 501
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 84.0 bits (206), Expect = 4e-16
Identities = 99/389 (25%), Positives = 152/389 (39%), Gaps = 45/389 (11%)
Query: 231 NPS-TKLQEGGSVTMTCSS-EGLPAPEIFWSKK---LDNGNLQHLSGNATLTLIAMRMED 285
NPS + G M C G P P I W K LD+ + + L + R D
Sbjct: 175 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSD 234
Query: 286 SGIYVCEGVNLIGKNRKEV-ELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRL 344
+G YVC G N++G+ EV EL V P + + + S C+ P+ +
Sbjct: 235 AGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARG-DPVPTV 293
Query: 345 EIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEP 404
GE E +D +K + T D G + C A+ + E
Sbjct: 294 RWRKDDGELPKSRYEIRDDHTLKIRK---------VTAGDMG-SYTCVAENMVGKAEASA 343
Query: 405 KQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL- 463
+V V PRD V + G +V C + G P P I W R+ L
Sbjct: 344 TLTVQEPPHFV-VKPRDQVVAL--------GRTVTFQCEATGNPQPAIFWRREGSQNLLF 394
Query: 464 --QP--------LSENATLTLISTKMEDSGVYLCEGINQAG----RSRKEVELIIQVTPK 509
QP +S+ LT+ + + D G Y+C+ +N AG ++ EV +I P
Sbjct: 395 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 454
Query: 510 DIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKK---AETGDTVLKSID-GAYTIRK 565
+ +++V T ++SC P I+ +K T D+ +K ++ G IR
Sbjct: 455 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 514
Query: 566 AQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
A+L D G Y C + G S ++VQ
Sbjct: 515 AKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
Score = 69.7 bits (169), Expect = 8e-12
Identities = 85/391 (21%), Positives = 148/391 (37%), Gaps = 57/391 (14%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSK--------KLDNGNLQHLSGNATLTLIAM-----R 282
+ +G T+ C +EG P P I W K K D + + L + +L + +
Sbjct: 79 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 138
Query: 283 MEDSGIYVCEGVNLIGK-----NRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPS 337
D G+YVC N +G+ EV ++ F ++P M + G + C+ P
Sbjct: 139 RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVM---VAVGEPAVMECQPPR 195
Query: 338 VYPLDRLEIELLKGETILENIEFLEDTDMK-SLENKSLEMTFIPTIEDTGKALVCQAKLH 396
+P + + ++ L+D D + ++ L +T+ D GK VC
Sbjct: 196 GHPEPTISWK--------KDGSPLDDKDERITIRGGKLMITYTRK-SDAGK-YVCVGTNM 245
Query: 397 IDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR 456
+ + E E + + V R + V + + S C ++G P P + W +
Sbjct: 246 VGERESEVAE--------LTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 297
Query: 457 ---QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKL 513
+LP + + ++ TL + D G Y C N G++ L +Q P +
Sbjct: 298 DDGELPKSRYE-IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 356
Query: 514 TAFPSESVKEGDTVIISCTCGNVPETWIILKKKA-----------ETGDTVLKSIDGAYT 562
+ V G TV C P+ I +++ ++ S G T
Sbjct: 357 PR--DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 414
Query: 563 IRKAQLKDAGVYECESKNKVGSQLRSLTLDV 593
I Q D G Y C++ N GS + L+V
Sbjct: 415 ITNVQRSDVGYYICQTLNVAGSIITKAYLEV 445
Score = 37.0 bits (84), Expect = 0.057
Identities = 46/183 (25%), Positives = 68/183 (37%), Gaps = 24/183 (13%)
Query: 431 ILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLSENATLTLIS----------T 477
I+ +G + C ++G P P I W ++ + P S L S
Sbjct: 78 IVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 137
Query: 478 KMEDSGVYLCEGINQAGRS-RKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISC-TCG 534
D GVY+C N G + L + + D + PS+ V G+ ++ C
Sbjct: 138 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--PSDVMVAVGEPAVMECQPPR 195
Query: 535 NVPETWIILKKKAETGDTVLKSI---DGAYTIRKAQLKDAGVYECESKNKVG---SQLRS 588
PE I KK D + I G I + DAG Y C N VG S++
Sbjct: 196 GHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE 255
Query: 589 LTL 591
LT+
Sbjct: 256 LTV 258
>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
sapiens]
Length = 848
Score = 83.6 bits (205), Expect = 5e-16
Identities = 115/537 (21%), Positives = 211/537 (39%), Gaps = 73/537 (13%)
Query: 8 ILGASNILWIMFAASQA--FKIETTPESRYLAQIGDSVSLTCSTTG-CESPFFSWRTQID 64
+L +++W +F A +++ P ++ +G+S C G + SW +
Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEIS-VGESKFFLCQVAGDAKDKDISWFSPNG 59
Query: 65 SPLNGK------VTNEGTTSTLTMNPVSFGNEHSYLCTATCES-RKLEKGIQVEIYSFPK 117
L V N+ ++STLT+ + + Y C T E + E + V+I+
Sbjct: 60 EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLM 119
Query: 118 DPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKS 177
G+ + C V P + + L K F+ L+ +
Sbjct: 120 FKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV-LSNNYLQIRG 178
Query: 178 LEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQ 237
++ T G++L R +++ ++ + V ++ Q VN + L
Sbjct: 179 IKKTDEGTYRCEGRILA-RGEINFKDIQVIVNVPPTIQARQNI---------VNATANL- 227
Query: 238 EGGSVTMTCSSEGLPAPEIFWSK-------KLDNGNLQHLSGNATLTLIAMRMEDSGIYV 290
G SVT+ C +EG P P + W+K + D+ ++ LT+ + D Y+
Sbjct: 228 -GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYI 286
Query: 291 CEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCK-----VPSVYPLDRLE 345
C N G+ + L V A P+ +E + VT++C+ +PS+
Sbjct: 287 CIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTR 346
Query: 346 IELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPK 405
+ +T+ ++ + SL KS++ T D G+ +C A I
Sbjct: 347 NISSEEKTLDGHMVVRSHARVSSLTLKSIQYT------DAGE-YICTASNTIG------- 392
Query: 406 QRQSTQTLYVNV--APRDTTVLVSPSSILE-EGSSVNMTCLSQGFPAPKILWSRQLPNGE 462
Q +Q++Y+ V AP+ L P ++ EG+ VN+TC +P+ I W R +G+
Sbjct: 393 --QDSQSMYLEVQYAPK----LQGPVAVYTWEGNQVNITCEVFAYPSATISWFR---DGQ 443
Query: 463 LQPLSENATLTLISTKM-----------EDSGVYLCEGINQAGRSRKEVELIIQVTP 508
L P S + + + +T D G Y C +N+ G+ E L+ TP
Sbjct: 444 LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
Score = 70.9 bits (172), Expect = 4e-12
Identities = 85/382 (22%), Positives = 147/382 (38%), Gaps = 52/382 (13%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQH-----LSGNATLTLIAMRMEDSGIY 289
+ +EG + C P I W K + L+ + N L + ++ D G Y
Sbjct: 128 EFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTY 187
Query: 290 VCEGVNLIGK--NRKEVELIVQAFPRDPEIEMSGGLVN-----GSSVTVSCKVPSVYPLD 342
CEG L N K++++IV P I+ +VN G SVT+ C +
Sbjct: 188 RCEGRILARGEINFKDIQVIVNV---PPTIQARQNIVNATANLGQSVTLVCDA------E 238
Query: 343 RLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEF 402
+ E IE ED + + S ++T ++ +C A
Sbjct: 239 GFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIA--------- 289
Query: 403 EPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLP 459
E K + T+++ V + V + +E V +TC + G P P I W +R +
Sbjct: 290 ENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNIS 349
Query: 460 NGE--------LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDI 511
+ E ++ + ++LTL S + D+G Y+C N G+ + + L +Q P
Sbjct: 350 SEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP--- 406
Query: 512 KLTAFPSESVKEGDTVIISCTCGNVPETWI-------ILKKKAETGDTVLKSIDGAY-TI 563
KL + EG+ V I+C P I +L + + + +Y +
Sbjct: 407 KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEV 466
Query: 564 RKAQLKDAGVYECESKNKVGSQ 585
D G Y C + N++G +
Sbjct: 467 TPDSENDFGNYNCTAVNRIGQE 488
Score = 67.0 bits (162), Expect = 5e-11
Identities = 75/348 (21%), Positives = 144/348 (41%), Gaps = 48/348 (13%)
Query: 273 NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQA-------FPRDPEIEMSGGLVN 325
++TLT+ ++D+GIY C + G++ E E V F P +
Sbjct: 78 SSTLTIYNANIDDAGIYKCV---VTGEDGSESEATVNVKIFQKLMFKNAPTPQE---FRE 131
Query: 326 GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDT 385
G + C V S P + + + +++ F+ ++ L+ + ++ T T
Sbjct: 132 GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN-NYLQIRGIKKTDEGTYRCE 190
Query: 386 GKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQ 445
G+ L + +++ D++ + VNV P ++ G SV + C ++
Sbjct: 191 GRILA-RGEINFKDIQ-----------VIVNVPPTIQARQNIVNATANLGQSVTLVCDAE 238
Query: 446 GFPAPKILWSR------QLPNGELQPLSENAT-LTLISTKMEDSGVYLCEGINQAGRSRK 498
GFP P + W++ Q + E S++++ LT+ D Y+C N+AG
Sbjct: 239 GFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDA 298
Query: 499 EVELIIQVTPKDIKLTAFPSESVKE-GDTVIISCTCGNVPETWIILKKKAETGDTVLKSI 557
+ L + PK +T +++ E + V ++C P I + + K++
Sbjct: 299 TIHLKVFAKPK---ITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTL 355
Query: 558 DG-----------AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
DG + T++ Q DAG Y C + N +G +S+ L+VQ
Sbjct: 356 DGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403
Score = 58.5 bits (140), Expect = 2e-08
Identities = 74/303 (24%), Positives = 117/303 (38%), Gaps = 42/303 (13%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWR---TQIDSPLNG-KVTNEGTTSTLTMNPVSFGNEHS 92
A +G SV+L C G P SW QI+ + K +S LT+ V +E
Sbjct: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
Query: 93 YLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVA-DVYPFDRLEID 151
Y+C A ++ + + I +++++ PK + +E + +T+ C + D P I
Sbjct: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIP----SIT 340
Query: 152 LLKGDHLMKSQEFLED--------ADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDE 203
+ S+E D A SL KS++ T D G+ +C A I +
Sbjct: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT------DAGE-YICTASNTIGQ 393
Query: 204 MDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW----- 258
DS L+V +PK + + EG V +TC P+ I W
Sbjct: 394 -DSQSMY------LEVQYAPK---LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 443
Query: 259 ---SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP 315
S N + + + L + D G Y C VN IG+ E L+ P P
Sbjct: 444 LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSP 503
Query: 316 EIE 318
I+
Sbjct: 504 SID 506
Score = 47.8 bits (112), Expect = 3e-05
Identities = 70/334 (20%), Positives = 127/334 (38%), Gaps = 53/334 (15%)
Query: 29 TTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQI------DSPLNGK--VTNEGTTSTL 80
T E++ ++ + V+LTC +G P +WRT + L+G V + S+L
Sbjct: 311 TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSL 370
Query: 81 TMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA----GKPITVK 136
T+ + + + Y+CTA+ + + + +E+ PK L GP+ G + +
Sbjct: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-----LQGPVAVYTWEGNQVNIT 425
Query: 137 CSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCR 196
C +V+ + I + L+ S + + LEV TP E+ C
Sbjct: 426 C---EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEV--TPDSENDFGNYNCT 480
Query: 197 AKLHID-----------EMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMT 245
A I + S P++ Q + P ++ V GG +
Sbjct: 481 AVNRIGQESLEFILVQADTPSSPSIDQ--------VEPYSSTAQVQFDEPEATGGVPILK 532
Query: 246 CSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVE 305
+E E W K + + G +T++ ++ E + Y L GK E+
Sbjct: 533 YKAEWRAVGEEVWHSKWYDAKEASMEG--IVTIVGLKPETT--YAVRLAALNGKGLGEIS 588
Query: 306 LI-------VQAFPRDPEIEMSGGLVNGSSVTVS 332
VQ P P++E G +G+S+ V+
Sbjct: 589 AASEFKTQPVQGEPSAPKLEGQMG-EDGNSIKVN 621
>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
sapiens]
Length = 761
Score = 83.6 bits (205), Expect = 5e-16
Identities = 115/537 (21%), Positives = 211/537 (39%), Gaps = 73/537 (13%)
Query: 8 ILGASNILWIMFAASQA--FKIETTPESRYLAQIGDSVSLTCSTTG-CESPFFSWRTQID 64
+L +++W +F A +++ P ++ +G+S C G + SW +
Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEIS-VGESKFFLCQVAGDAKDKDISWFSPNG 59
Query: 65 SPLNGK------VTNEGTTSTLTMNPVSFGNEHSYLCTATCES-RKLEKGIQVEIYSFPK 117
L V N+ ++STLT+ + + Y C T E + E + V+I+
Sbjct: 60 EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLM 119
Query: 118 DPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKS 177
G+ + C V P + + L K F+ L+ +
Sbjct: 120 FKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV-LSNNYLQIRG 178
Query: 178 LEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQ 237
++ T G++L R +++ ++ + V ++ Q VN + L
Sbjct: 179 IKKTDEGTYRCEGRILA-RGEINFKDIQVIVNVPPTIQARQNI---------VNATANL- 227
Query: 238 EGGSVTMTCSSEGLPAPEIFWSK-------KLDNGNLQHLSGNATLTLIAMRMEDSGIYV 290
G SVT+ C +EG P P + W+K + D+ ++ LT+ + D Y+
Sbjct: 228 -GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYI 286
Query: 291 CEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCK-----VPSVYPLDRLE 345
C N G+ + L V A P+ +E + VT++C+ +PS+
Sbjct: 287 CIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTR 346
Query: 346 IELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPK 405
+ +T+ ++ + SL KS++ T D G+ +C A I
Sbjct: 347 NISSEEKTLDGHMVVRSHARVSSLTLKSIQYT------DAGE-YICTASNTIG------- 392
Query: 406 QRQSTQTLYVNV--APRDTTVLVSPSSILE-EGSSVNMTCLSQGFPAPKILWSRQLPNGE 462
Q +Q++Y+ V AP+ L P ++ EG+ VN+TC +P+ I W R +G+
Sbjct: 393 --QDSQSMYLEVQYAPK----LQGPVAVYTWEGNQVNITCEVFAYPSATISWFR---DGQ 443
Query: 463 LQPLSENATLTLISTKM-----------EDSGVYLCEGINQAGRSRKEVELIIQVTP 508
L P S + + + +T D G Y C +N+ G+ E L+ TP
Sbjct: 444 LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
Score = 70.9 bits (172), Expect = 4e-12
Identities = 85/382 (22%), Positives = 147/382 (38%), Gaps = 52/382 (13%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQH-----LSGNATLTLIAMRMEDSGIY 289
+ +EG + C P I W K + L+ + N L + ++ D G Y
Sbjct: 128 EFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTY 187
Query: 290 VCEGVNLIGK--NRKEVELIVQAFPRDPEIEMSGGLVN-----GSSVTVSCKVPSVYPLD 342
CEG L N K++++IV P I+ +VN G SVT+ C +
Sbjct: 188 RCEGRILARGEINFKDIQVIVNV---PPTIQARQNIVNATANLGQSVTLVCDA------E 238
Query: 343 RLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEF 402
+ E IE ED + + S ++T ++ +C A
Sbjct: 239 GFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIA--------- 289
Query: 403 EPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLP 459
E K + T+++ V + V + +E V +TC + G P P I W +R +
Sbjct: 290 ENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNIS 349
Query: 460 NGE--------LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDI 511
+ E ++ + ++LTL S + D+G Y+C N G+ + + L +Q P
Sbjct: 350 SEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP--- 406
Query: 512 KLTAFPSESVKEGDTVIISCTCGNVPETWI-------ILKKKAETGDTVLKSIDGAY-TI 563
KL + EG+ V I+C P I +L + + + +Y +
Sbjct: 407 KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEV 466
Query: 564 RKAQLKDAGVYECESKNKVGSQ 585
D G Y C + N++G +
Sbjct: 467 TPDSENDFGNYNCTAVNRIGQE 488
Score = 67.0 bits (162), Expect = 5e-11
Identities = 75/348 (21%), Positives = 144/348 (41%), Gaps = 48/348 (13%)
Query: 273 NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQA-------FPRDPEIEMSGGLVN 325
++TLT+ ++D+GIY C + G++ E E V F P +
Sbjct: 78 SSTLTIYNANIDDAGIYKCV---VTGEDGSESEATVNVKIFQKLMFKNAPTPQE---FRE 131
Query: 326 GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDT 385
G + C V S P + + + +++ F+ ++ L+ + ++ T T
Sbjct: 132 GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN-NYLQIRGIKKTDEGTYRCE 190
Query: 386 GKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQ 445
G+ L + +++ D++ + VNV P ++ G SV + C ++
Sbjct: 191 GRILA-RGEINFKDIQ-----------VIVNVPPTIQARQNIVNATANLGQSVTLVCDAE 238
Query: 446 GFPAPKILWSR------QLPNGELQPLSENAT-LTLISTKMEDSGVYLCEGINQAGRSRK 498
GFP P + W++ Q + E S++++ LT+ D Y+C N+AG
Sbjct: 239 GFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDA 298
Query: 499 EVELIIQVTPKDIKLTAFPSESVKE-GDTVIISCTCGNVPETWIILKKKAETGDTVLKSI 557
+ L + PK +T +++ E + V ++C P I + + K++
Sbjct: 299 TIHLKVFAKPK---ITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTL 355
Query: 558 DG-----------AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
DG + T++ Q DAG Y C + N +G +S+ L+VQ
Sbjct: 356 DGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403
Score = 58.5 bits (140), Expect = 2e-08
Identities = 74/303 (24%), Positives = 117/303 (38%), Gaps = 42/303 (13%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWR---TQIDSPLNG-KVTNEGTTSTLTMNPVSFGNEHS 92
A +G SV+L C G P SW QI+ + K +S LT+ V +E
Sbjct: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
Query: 93 YLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVA-DVYPFDRLEID 151
Y+C A ++ + + I +++++ PK + +E + +T+ C + D P I
Sbjct: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIP----SIT 340
Query: 152 LLKGDHLMKSQEFLED--------ADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDE 203
+ S+E D A SL KS++ T D G+ +C A I +
Sbjct: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT------DAGE-YICTASNTIGQ 393
Query: 204 MDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW----- 258
DS L+V +PK + + EG V +TC P+ I W
Sbjct: 394 -DSQSMY------LEVQYAPK---LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 443
Query: 259 ---SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP 315
S N + + + L + D G Y C VN IG+ E L+ P P
Sbjct: 444 LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSP 503
Query: 316 EIE 318
I+
Sbjct: 504 SID 506
>gi|189571583 intercellular adhesion molecule 5 precursor [Homo
sapiens]
Length = 924
Score = 83.6 bits (205), Expect = 5e-16
Identities = 151/689 (21%), Positives = 251/689 (36%), Gaps = 127/689 (18%)
Query: 36 LAQIGDSVSLTCSTTGCESPFFSWRTQI---DSPLNGKVTNEG----TTSTLTMNPVSFG 88
L ++G ++C+ G P R + D L+ VT EG T+T T + G
Sbjct: 238 LLEVGSERPVSCTLDGL-FPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEG 296
Query: 89 NEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGP-LEAGKPITVKCS--------- 138
+C T E V IYSFP P + LS P + G+ +TV C+
Sbjct: 297 -ARQLVCNVTLGGENRETRENVTIYSFPA-PLLTLSEPSVSEGQMVTVTCAAGAQALVTL 354
Query: 139 --VADVYPFDRLEIDLLKGDHLMKSQEFLE---DADRKSL---ETKSLEVTFTPVIEDIG 190
V P ++ L ++ + F + D D ++L + L V + P ++D
Sbjct: 355 EGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSD 414
Query: 191 ------------KVLVCRAK------LHIDEMDSV---------PTVR------------ 211
+ L C A+ +H D P R
Sbjct: 415 CPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAAN 474
Query: 212 ---QAVKELQVYISPKNTVISVNPSTKLQ--EGGSVTMTCSSEGLPAPEIFWSKKLDNGN 266
+AVK++ + + + SV ++ EG +++C + G+P P++ + +G
Sbjct: 475 DQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVR---SGE 531
Query: 267 LQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPR--DPEIEMSGGLV 324
L G L+ + E +G Y CE N G K V + V+ PR +P + V
Sbjct: 532 L----GAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWV 587
Query: 325 NGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIED 384
GS SC+V + ++ + E + S + P I
Sbjct: 588 EGSGRLFSCEVDGK---PQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGI-- 642
Query: 385 TGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAP---RDTTVLVSPSSILEEGSSVNMT 441
VC A + +T+ V+ D + S + LE + +
Sbjct: 643 ----YVCNAT---------NRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALA 689
Query: 442 CLSQGFPAPKILWSRQ-LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEV 500
C ++G P+P + SR+ +P E Q +S ED+G Y C N G + V
Sbjct: 690 CAARGRPSPGVRCSREGIPWPEQQRVSR-----------EDAGTYHCVATNAHGTDSRTV 738
Query: 501 ELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGA 560
+ ++ P +L A P V+ G ++C P I + + L S +
Sbjct: 739 TVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNST 798
Query: 561 YTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLY----FASSL 616
++ A G YEC + N G R +T+ V G P L V ++L
Sbjct: 799 LSVAGAMGSHGGEYECAATNAHGRHARRITVRVAG---------PWLWVAVGGAAGGAAL 849
Query: 617 IIPAIGMIIYFARKANMKGSYSLVEAQKS 645
+ G+ Y A KG Y++ EA+ S
Sbjct: 850 LAAGAGLAFYVQSTACKKGEYNVQEAESS 878
Score = 81.3 bits (199), Expect = 3e-15
Identities = 136/578 (23%), Positives = 219/578 (37%), Gaps = 78/578 (13%)
Query: 40 GDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATC 99
G S+ L CST C P R +++ L T G E +C C
Sbjct: 48 GGSLWLNCSTN-CPRPE---RGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRC 103
Query: 100 ESRKLEKGIQVEIYSFPKDPEIHLSGPLE-AGKPITVKCSVADVYPFDRLEIDLLKGDHL 158
R L+ + + P E+ P + G+ T+ C V P L + LL+G
Sbjct: 104 ARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQE 163
Query: 159 MKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHID-------EMDSVPTVR 211
+ + F + R L T ED G CRA+L + E S P
Sbjct: 164 LIRRSFAGEPPRA--RGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAP--- 218
Query: 212 QAVKELQVY-ISPKNTVISVNPSTKLQEGGSVTMTCSSEGL-PAPEIFWSKKLDNGNLQH 269
+EL+ + +SP ++ L+ G ++C+ +GL PA E L + NL
Sbjct: 219 ---RELRTFSLSPDAPRLAA--PRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSP 273
Query: 270 ---LSGNA---TLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELI-VQAFPRDPEIEMSGG 322
L G+A T T A ++ + V L G+NR+ E + + +FP P + +S
Sbjct: 274 DVTLEGDAFVATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPA-PLLTLSEP 332
Query: 323 LVN-GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPT 381
V+ G VTV+C G L +E + ++ + ++ T
Sbjct: 333 SVSEGQMVTVTCAA---------------GAQALVTLEGVP----AAVPGQPAQLQLNAT 373
Query: 382 IEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMT 441
D ++ C A L +D + + LY APR S EG +
Sbjct: 374 ENDDRRSFFCDATLDVDGETLIKNRSAELRVLY---APRLDDSDCPRSWTWPEGPEQTLR 430
Query: 442 CLSQGFPAPKILWSRQ-----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRS 496
C ++G P P + +R L G L P++ SG Y C+ N G +
Sbjct: 431 CEARGNPEPSVHCARSDGGAVLALGLLGPVTRAL-----------SGTYRCKAANDQGEA 479
Query: 497 RKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKS 556
K+V L ++ P + + EG +SC VP +I + E G
Sbjct: 480 VKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAV---- 535
Query: 557 IDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
I+G + + + AG Y CE+ N GS +++ + V+
Sbjct: 536 IEGLLRVAR---EHAGTYRCEATNPRGSAAKNVAVTVE 570
Score = 45.1 bits (105), Expect = 2e-04
Identities = 80/331 (24%), Positives = 135/331 (40%), Gaps = 60/331 (18%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQ-HLSGNAT---LTLIAMRMEDSGIYVC 291
++ GGS+ + CS+ P PE G L+ L N T L +A ++ D
Sbjct: 45 VERGGSLWLNCSTN-CPRPE--------RGGLETSLRRNGTQRGLRWLARQLVDIREPET 95
Query: 292 EGVNLIGKNRKEVEL--IVQAFPRDPEIEMSG---GLVNGSSVTVSCKVPSVYPLDRLEI 346
+ V R+ ++ +++ F R +E+ G + T+SC+VP P L +
Sbjct: 96 QPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTL 155
Query: 347 ELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQ 406
LL+G L F + L T + ED G C+A+L +
Sbjct: 156 TLLRGAQELIRRSFAGEP--PRARGAVLTATVLARREDHGANFSCRAELDL--------- 204
Query: 407 RQSTQTLYVN-VAPRD-TTVLVSPSS-------ILEEGSSVNMTCLSQG-FPAPK----- 451
R L+ N APR+ T +SP + +LE GS ++C G FPA +
Sbjct: 205 RPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYL 264
Query: 452 ILWSRQL-PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKD 510
L + L P+ L+ + AT T ++ ++ L + G +R+ T ++
Sbjct: 265 ALGDQNLSPDVTLEGDAFVATATATASAEQEGARQLVCNVTLGGENRE--------TREN 316
Query: 511 IKLTAFPS-------ESVKEGDTVIISCTCG 534
+ + +FP+ SV EG V ++C G
Sbjct: 317 VTIYSFPAPLLTLSEPSVSEGQMVTVTCAAG 347
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 83.2 bits (204), Expect = 7e-16
Identities = 90/376 (23%), Positives = 148/376 (39%), Gaps = 42/376 (11%)
Query: 242 VTMTCSSEGLPAPEIFWSK-----KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNL 296
V + C + P W KL+ G+ L G + + + +D+G+Y C N
Sbjct: 57 VLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNP 116
Query: 297 IGKNRKEVELI----VQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGE 352
+G ++ +Q F ++ + G V + C P+ YP L
Sbjct: 117 VGTVVSREAILRFGFLQEFSKEERDPVKAH--EGWGVMLPCNPPAHYPG-------LSYR 167
Query: 353 TILENIEFLEDTDMKSLENKSLEMTFIP--TIEDTGKALVCQAKLHIDDMEFEPKQRQST 410
+L TD + +++ +I D G C A H+D F K S
Sbjct: 168 WLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGN-YSCLATSHMD---FSTKSVFS- 222
Query: 411 QTLYVNVAPRDTTVLVSPS--------SILEEGSSVNMTCLSQGFPAPKILWSRQLPNGE 462
+ +N+A DT L +PS + G V + C + G P P+I W + +G
Sbjct: 223 KFAQLNLAAEDTR-LFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKV--DGS 279
Query: 463 LQPLSENA--TLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSES 520
L P A TL + S ED G Y CE N GR + +I+Q P+ +K+ +
Sbjct: 280 LSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEAD 339
Query: 521 VKEGDTVIISCTCGNVPETWIILKKKAE--TGDTVLKSIDGAYTIRKAQLKDAGVYECES 578
+ G + C P + + E ++ + G K L+D+G+Y+C +
Sbjct: 340 I--GSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVA 397
Query: 579 KNKVGSQLRSLTLDVQ 594
+NK G+ S L VQ
Sbjct: 398 ENKHGTIYASAELAVQ 413
Score = 77.8 bits (190), Expect = 3e-14
Identities = 93/386 (24%), Positives = 151/386 (39%), Gaps = 62/386 (16%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIG 298
G VT+ C + G P P I W K + + Q + TL + ++ ED G Y CE N G
Sbjct: 254 GQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKG 313
Query: 299 KNRKEVELIVQAFPR------DPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLE------- 345
++ + +IVQA P D E ++ L G + + P+V L E
Sbjct: 314 RDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPR-PTVRWLRNGEPLASQNR 372
Query: 346 IELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPK 405
+E+L G+ + LED+ M ++ T + E +AL D P
Sbjct: 373 VEVLAGDLRFSKLS-LEDSGMYQCVAENKHGTIYASAELAVQALA-------PDFRLNPV 424
Query: 406 QRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ---LPNGE 462
+R + P++ G + + C + P +LWS+ L N
Sbjct: 425 RR------------------LIPAA---RGGEILIPCQPRAAPKAVVLWSKGTEILVNSS 463
Query: 463 LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSES-V 521
++ + TL + + D G Y C N G++ L ++ K+T PS + +
Sbjct: 464 RVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVR---DATKITLAPSSADI 520
Query: 522 KEGDTVIISCTCGNVPE-----TWII-------LKKKAETGDTVLKSIDGAYTIRKAQLK 569
GD + + C + P TW + K T +K G TI AQL+
Sbjct: 521 NLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLR 580
Query: 570 DAGVYECESKNKVGSQLRSLTLDVQG 595
G Y C ++ V S + T+ V+G
Sbjct: 581 HGGKYTCMAQTVVDSASKEATVLVRG 606
Score = 48.9 bits (115), Expect = 1e-05
Identities = 66/304 (21%), Positives = 118/304 (38%), Gaps = 31/304 (10%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTS--TLTMNPVSFGNEHSYL 94
A +G V+L C G P WR ++G ++ + TT+ TL + VSF +E +Y
Sbjct: 251 ALVGQQVTLECFAFGNPVPRIKWR-----KVDGSLSPQWTTAEPTLQIPSVSFEDEGTYE 305
Query: 95 CTA-TCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLL 153
C A + R +G ++ + + P+ ++ + G + C+ A R + L
Sbjct: 306 CEAENSKGRDTVQG-RIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGK---PRPTVRWL 361
Query: 154 KGDHLMKSQEFLEDADRKSLETKSLEVTFTPV-IEDIGKVLVCRAKLHIDEMDSVPTVRQ 212
+ + SQ +E + ++ F+ + +ED G H S Q
Sbjct: 362 RNGEPLASQ--------NRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQ 413
Query: 213 AVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK---LDNGNLQH 269
A ++P + V GG + + C P + WSK L N +
Sbjct: 414 A-------LAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVT 466
Query: 270 LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSV 329
++ + TL + + D G Y C N +GK L V+ + S + G ++
Sbjct: 467 VTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNL 526
Query: 330 TVSC 333
T+ C
Sbjct: 527 TLQC 530
Score = 47.8 bits (112), Expect = 3e-05
Identities = 66/301 (21%), Positives = 120/301 (39%), Gaps = 42/301 (13%)
Query: 228 ISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAMRM 283
+ V T+ G ++ C++ G P P + W + ++ L+G+ L + +
Sbjct: 330 LKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGD--LRFSKLSL 387
Query: 284 EDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLV---NGSSVTVSCKVPSVYP 340
EDSG+Y C N G EL VQA D + L+ G + + C+ P P
Sbjct: 388 EDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ-PRAAP 446
Query: 341 LDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDM 400
+ + KG IL N + T +L +++ + D GK C A+ +
Sbjct: 447 --KAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRS------DEGK-YTCFAENFMG-- 495
Query: 401 EFEPKQRQSTQTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILWSRQL- 458
+ ST L V A T + ++PSS + G ++ + C + P + ++ L
Sbjct: 496 -----KANSTGILSVRDA---TKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLD 547
Query: 459 --------PNGELQPLSENAT---LTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVT 507
P G + + T LT+++ ++ G Y C + KE ++++
Sbjct: 548 DFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGP 607
Query: 508 P 508
P
Sbjct: 608 P 608
Score = 32.3 bits (72), Expect = 1.4
Identities = 63/306 (20%), Positives = 116/306 (37%), Gaps = 46/306 (15%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCT 96
A IG ++ C+ G P W PL + E L + +S + Y C
Sbjct: 338 ADIGSNLRWGCAAAGKPRPTVRWLRN-GEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCV 396
Query: 97 ATCESRKL----EKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDL 152
A + + E +Q F +P L P G I + C P + +
Sbjct: 397 AENKHGTIYASAELAVQALAPDFRLNPVRRLI-PAARGGEILIPCQ-----PRAAPKAVV 450
Query: 153 LKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDS--VPTV 210
L K E L ++ R ++ + D GK C A+ + + +S + +V
Sbjct: 451 LWS----KGTEILVNSSRVTVTPDGTLIIRNISRSDEGKY-TCFAENFMGKANSTGILSV 505
Query: 211 RQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDN------ 264
R A K + ++P + I++ G ++T+ C + P ++ ++ LD+
Sbjct: 506 RDATK---ITLAPSSADINL--------GDNLTLQCHASHDPTMDLTFTWTLDDFPIDFD 554
Query: 265 ---GNLQHLSGNAT---LTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIE 318
G+ + + T LT++ ++ G Y C ++ KE ++V+ P P
Sbjct: 555 KPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPP--- 611
Query: 319 MSGGLV 324
GG+V
Sbjct: 612 --GGVV 615
>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
Length = 837
Score = 83.2 bits (204), Expect = 7e-16
Identities = 102/412 (24%), Positives = 174/412 (42%), Gaps = 68/412 (16%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW----SKKLDNGN---LQH 269
LQV IS +SV G S TC++ G P I W +K+ + +Q
Sbjct: 21 LQVTISLSKVELSV--------GESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQK 71
Query: 270 LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDP--EIEMSGGLVNGS 327
+ LT+ +ED+GIY C+ + G+ + E ++++ + + E+ G
Sbjct: 72 EGVRSRLTIYNANIEDAGIYRCQATDAKGQTQ-EATVVLEIYQKLTFREVVSPQEFKQGE 130
Query: 328 SVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGK 387
V C+V S + E + + D L N +L++ I ++
Sbjct: 131 DAEVVCRVSSS------PAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEG-- 182
Query: 388 ALVCQAKLHI-DDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQG 446
C+ ++ +++F + VNV P + S ++ E G + +C + G
Sbjct: 183 IYRCEGRVEARGEIDFRDI------IVIVNVPPAISMPQKSFNATAERGEEMTFSCRASG 236
Query: 447 FPAPKILWSRQLPNGELQPLSE-------NATLTLISTKMEDSGVYLCEGINQAGRSRKE 499
P P I W R NG+L +E N LT+ + D G Y+C N+AG K+
Sbjct: 237 SPEPAISWFR---NGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQ 293
Query: 500 VELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGN--VPE-TWIILKKKAETGDTVL-- 554
L + V P I+L +E+ E V + C +PE TW K+A G T
Sbjct: 294 AFLQVFVQPHIIQLK---NETTYENGQVTLVCDAEGEPIPEITW----KRAVDGFTFTEG 346
Query: 555 -KSIDG-----------AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 594
KS+DG + I+ +L D+G Y+CE+ +++G +S+ LD++
Sbjct: 347 DKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIE 398
Score = 75.9 bits (185), Expect = 1e-13
Identities = 100/437 (22%), Positives = 176/437 (40%), Gaps = 62/437 (14%)
Query: 186 IEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMT 245
IED G + C+A D+ ++A L++Y K T V + ++G +
Sbjct: 85 IEDAG-IYRCQAT------DAKGQTQEATVVLEIY--QKLTFREVVSPQEFKQGEDAEVV 135
Query: 246 CSSEGLPAPEIFWSKKLD-----NGNLQHLSGNATLTLIAMRMEDSGIYVCEG-VNLIGK 299
C PAP + W + + N + N L ++ + D GIY CEG V G+
Sbjct: 136 CRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGE 195
Query: 300 -NRKEVELIVQAFPRD--PEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILE 356
+ +++ +IV P P+ + G +T SC+ S P + +
Sbjct: 196 IDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRA-SGSPEPAI--------SWFR 246
Query: 357 NIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVN 416
N + +E+ + L+ + E+T I G VC+A K + + ++
Sbjct: 247 NGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRAT---------NKAGEDEKQAFLQ 297
Query: 417 VAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLP-----------NGELQP 465
V + + + + E G V + C ++G P P+I W R + +G ++
Sbjct: 298 VFVQPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEV 356
Query: 466 LSEN--ATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDI-KLTAFPSESVK 522
++ ++L + K+ DSG Y CE ++ G +K + L I+ PK I T + S
Sbjct: 357 KGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYS---W 413
Query: 523 EGDTVIISCTCGNVPET---W----IILKKKAETG-DTVLKSIDGAYTIRKAQLKDAGVY 574
EG+ + ISC + P W ++L K T T I D G Y
Sbjct: 414 EGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRY 473
Query: 575 ECESKNKVGSQLRSLTL 591
C + N +G++ + L
Sbjct: 474 NCTATNHIGTRFQEYIL 490
Score = 70.9 bits (172), Expect = 4e-12
Identities = 74/323 (22%), Positives = 140/323 (43%), Gaps = 44/323 (13%)
Query: 40 GDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G+ + C + +P SW ++ + + + + +N ++ +E Y C
Sbjct: 129 GEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILN-INKSDEGIYRCE 187
Query: 97 ATCESR-KLEKGIQVEIYSFPKD---PEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDL 152
E+R +++ + I + P P+ + E G+ +T C A P +
Sbjct: 188 GRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCR-ASGSPEPAIS--- 243
Query: 153 LKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQ 212
++ + +E+ ++ L+ + E+T +I G VCRA E + +Q
Sbjct: 244 -----WFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDE-----KQ 293
Query: 213 AVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLD--------- 263
A LQV++ P +I + T E G VT+ C +EG P PEI W + +D
Sbjct: 294 AF--LQVFVQPH--IIQLKNETTY-ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDK 348
Query: 264 --NGNL----QHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEI 317
+G + QH G+++L + +++ DSG Y CE + IG ++K + L ++ P+
Sbjct: 349 SLDGRIEVKGQH--GSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISN 406
Query: 318 EMSGGLVNGSSVTVSCKVPSVYP 340
+ G+ + +SC V S P
Sbjct: 407 QTIYYSWEGNPINISCDVKSNPP 429
Score = 66.6 bits (161), Expect = 7e-11
Identities = 116/521 (22%), Positives = 193/521 (37%), Gaps = 59/521 (11%)
Query: 14 ILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRT----QIDSPLNG 69
+L ++ ++ QA T S+ +G+S TC+ G E W +I S
Sbjct: 9 LLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIG-EPESIDWYNPQGEKIISTQRV 67
Query: 70 KVTNEGTTSTLTMNPVSFGNEHSYLCTAT-CESRKLEKGIQVEIYSFPKDPEIHLSGPLE 128
V EG S LT+ + + Y C AT + + E + +EIY E+ +
Sbjct: 68 VVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFK 127
Query: 129 AGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIED 188
G+ V C V+ P + + S +L+ ++ + +
Sbjct: 128 QGEDAEVVCRVSS-SPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRC 186
Query: 189 IGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS 248
G+V A+ ID D + V + P ++ + + + G +T +C +
Sbjct: 187 EGRV---EARGEIDFRDIIVIVN---------VPPAISMPQKSFNATAERGEEMTFSCRA 234
Query: 249 EGLPAPEIFWSK--KLDNGNLQHL--SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV 304
G P P I W + KL N +++ N LT+ + D G YVC N G++ K+
Sbjct: 235 SGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQA 294
Query: 305 ELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLED- 363
L V P +++ NG VT+ C + + G T E + L+
Sbjct: 295 FLQVFVQPHIIQLKNETTYENG-QVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGR 353
Query: 364 TDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHID--------DMEFEPKQRQSTQTLYV 415
++K S + D+G+ C+A I D+E+ PK S QT+Y
Sbjct: 354 IEVKGQHGSSSLHIKDVKLSDSGR-YDCEAASRIGGHQKSMYLDIEYAPK-FISNQTIYY 411
Query: 416 NVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ---LPNGELQPLSENAT- 471
+ EG+ +N++C + P I W R LP L +T
Sbjct: 412 S----------------WEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTG 455
Query: 472 ----LTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP 508
L + T D G Y C N G +E L + P
Sbjct: 456 RKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVP 496
Score = 30.0 bits (66), Expect = 6.9
Identities = 21/90 (23%), Positives = 44/90 (48%), Gaps = 7/90 (7%)
Query: 524 GDTVIISCTCGNVPETWIILKKKAE----TGDTVLKS--IDGAYTIRKAQLKDAGVYECE 577
G++ +CT PE+ + E T V++ + TI A ++DAG+Y C+
Sbjct: 35 GESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQ 94
Query: 578 SKNKVG-SQLRSLTLDVQGRENNKDYFSPE 606
+ + G +Q ++ L++ + ++ SP+
Sbjct: 95 ATDAKGQTQEATVVLEIYQKLTFREVVSPQ 124
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,305,811
Number of Sequences: 37866
Number of extensions: 1106542
Number of successful extensions: 7258
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 191
Number of HSP's successfully gapped in prelim test: 220
Number of HSP's that attempted gapping in prelim test: 2676
Number of HSP's gapped (non-prelim): 2792
length of query: 647
length of database: 18,247,518
effective HSP length: 109
effective length of query: 538
effective length of database: 14,120,124
effective search space: 7596626712
effective search space used: 7596626712
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.