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Search of human proteins with 169403944
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169403944 WD repeat domain 26 isoform b [Homo sapiens]
(498 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169403944 WD repeat domain 26 isoform b [Homo sapiens] 1045 0.0
gi|55743153 WD repeat domain 26 isoform a [Homo sapiens] 1035 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 101 1e-21
gi|16554627 WD repeat domain 5 [Homo sapiens] 101 1e-21
gi|23199987 WD repeat domain 5B [Homo sapiens] 100 5e-21
gi|4757988 WD repeat domain 39 [Homo sapiens] 87 5e-17
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 82 9e-16
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 82 1e-15
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] 78 2e-14
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens] 78 2e-14
gi|21071067 TBP-associated factor 5 [Homo sapiens] 75 2e-13
gi|32189425 WD repeat domain 69 [Homo sapiens] 68 2e-11
gi|113865883 WD repeat domain 38 [Homo sapiens] 66 6e-11
gi|109627650 coronin 6 [Homo sapiens] 66 6e-11
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 66 8e-11
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 66 8e-11
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 65 1e-10
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 65 1e-10
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 65 1e-10
gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo sa... 65 1e-10
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 65 1e-10
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 65 1e-10
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 64 2e-10
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 64 3e-10
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 64 3e-10
gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens] 64 4e-10
gi|148727341 serine/threonine kinase receptor associated protein... 63 5e-10
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 62 9e-10
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 62 9e-10
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 62 9e-10
>gi|169403944 WD repeat domain 26 isoform b [Homo sapiens]
Length = 498
Score = 1045 bits (2703), Expect = 0.0
Identities = 498/498 (100%), Positives = 498/498 (100%)
Query: 1 MQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVRMKFLLLQQKYLEY 60
MQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVRMKFLLLQQKYLEY
Sbjct: 1 MQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVRMKFLLLQQKYLEY 60
Query: 61 LEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGTASRSKLL 120
LEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGTASRSKLL
Sbjct: 61 LEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGTASRSKLL 120
Query: 121 DKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDNNLDSVSLLIDHVCSRRQF 180
DKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDNNLDSVSLLIDHVCSRRQF
Sbjct: 121 DKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDNNLDSVSLLIDHVCSRRQF 180
Query: 181 PCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYG 240
PCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYG
Sbjct: 181 PCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYG 240
Query: 241 VSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVT 300
VSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVT
Sbjct: 241 VSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVT 300
Query: 301 GGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIV 360
GGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIV
Sbjct: 301 GGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIV 360
Query: 361 QEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNE 420
QEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNE
Sbjct: 361 QEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNE 420
Query: 421 DFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGP 480
DFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGP
Sbjct: 421 DFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGP 480
Query: 481 APFIDHQNIEEECSSMDS 498
APFIDHQNIEEECSSMDS
Sbjct: 481 APFIDHQNIEEECSSMDS 498
>gi|55743153 WD repeat domain 26 isoform a [Homo sapiens]
Length = 514
Score = 1035 bits (2676), Expect = 0.0
Identities = 498/514 (96%), Positives = 498/514 (96%), Gaps = 16/514 (3%)
Query: 1 MQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIV-------------- 46
MQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIV
Sbjct: 1 MQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVVRGALEISQTLLGI 60
Query: 47 --RMKFLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRA 104
RMKFLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRA
Sbjct: 61 IVRMKFLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRA 120
Query: 105 KAEWEGKGTASRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDNNL 164
KAEWEGKGTASRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDNNL
Sbjct: 121 KAEWEGKGTASRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDNNL 180
Query: 165 DSVSLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPD 224
DSVSLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPD
Sbjct: 181 DSVSLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPD 240
Query: 225 THLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHED 284
THLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHED
Sbjct: 241 THLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHED 300
Query: 285 SLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQ 344
SLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQ
Sbjct: 301 SLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQ 360
Query: 345 RIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGV 404
RIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGV
Sbjct: 361 RIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGV 420
Query: 405 TQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPS 464
TQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPS
Sbjct: 421 TQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPS 480
Query: 465 MMASASDDGTVRIWGPAPFIDHQNIEEECSSMDS 498
MMASASDDGTVRIWGPAPFIDHQNIEEECSSMDS
Sbjct: 481 MMASASDDGTVRIWGPAPFIDHQNIEEECSSMDS 514
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 101 bits (252), Expect = 1e-21
Identities = 84/298 (28%), Positives = 137/298 (45%), Gaps = 15/298 (5%)
Query: 188 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWS 247
L H V KFS +G LA+ S D + IW K KT+ GH G+S +AWS
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG----KFEKTISGHKLGISDVAWS 96
Query: 248 PDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQF 307
D N LV+ D L +W+V +G+ K + H + + +NP V+G
Sbjct: 97 SDSNLLVSASDD--KTLKIWDVSSGKC-LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 308 YQCDLD-GNLLDSWEGVR--VQCLWCLSDGKTVLASDTHQRIRGYNFED-LTDRNIVQED 363
D+ G L + V + DG +++S R ++ + ++ +D
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
Query: 364 HPIMSFT-ISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDF 422
+P +SF S NG+ L + LWD ++ Y G Y I + F +
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273
Query: 423 IASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASAS--DDGTVRIW 478
I SGSED+ VYIW+ +++ + +L GHT V + +P +++ASA+ +D T+++W
Sbjct: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP-TENIIASAALENDKTIKLW 330
Score = 40.0 bits (92), Expect = 0.005
Identities = 26/93 (27%), Positives = 43/93 (46%), Gaps = 4/93 (4%)
Query: 389 LWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTG 448
+WD+ ++ +G + + C + I SGS D V IW ++ + L
Sbjct: 113 IWDVSSGKCLKTLKGHSN---YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA 169
Query: 449 HTRTVNCVSWNPQIPSMMASASDDGTVRIWGPA 481
H+ V+ V +N S++ S+S DG RIW A
Sbjct: 170 HSDPVSAVHFNRD-GSLIVSSSYDGLCRIWDTA 201
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 101 bits (252), Expect = 1e-21
Identities = 84/298 (28%), Positives = 137/298 (45%), Gaps = 15/298 (5%)
Query: 188 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWS 247
L H V KFS +G LA+ S D + IW K KT+ GH G+S +AWS
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG----KFEKTISGHKLGISDVAWS 96
Query: 248 PDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQF 307
D N LV+ D L +W+V +G+ K + H + + +NP V+G
Sbjct: 97 SDSNLLVSASDD--KTLKIWDVSSGKC-LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 308 YQCDLD-GNLLDSWEGVR--VQCLWCLSDGKTVLASDTHQRIRGYNFED-LTDRNIVQED 363
D+ G L + V + DG +++S R ++ + ++ +D
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
Query: 364 HPIMSFT-ISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDF 422
+P +SF S NG+ L + LWD ++ Y G Y I + F +
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273
Query: 423 IASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASAS--DDGTVRIW 478
I SGSED+ VYIW+ +++ + +L GHT V + +P +++ASA+ +D T+++W
Sbjct: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP-TENIIASAALENDKTIKLW 330
Score = 40.0 bits (92), Expect = 0.005
Identities = 26/93 (27%), Positives = 43/93 (46%), Gaps = 4/93 (4%)
Query: 389 LWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTG 448
+WD+ ++ +G + + C + I SGS D V IW ++ + L
Sbjct: 113 IWDVSSGKCLKTLKGHSN---YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA 169
Query: 449 HTRTVNCVSWNPQIPSMMASASDDGTVRIWGPA 481
H+ V+ V +N S++ S+S DG RIW A
Sbjct: 170 HSDPVSAVHFNRD-GSLIVSSSYDGLCRIWDTA 201
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 99.8 bits (247), Expect = 5e-21
Identities = 79/297 (26%), Positives = 137/297 (46%), Gaps = 49/297 (16%)
Query: 185 QQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYI 244
++ L H E+ +S+D ++L + S D T+ +W V K LKTL+GH+ V
Sbjct: 76 EKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG----KCLKTLKGHSNYVFCC 131
Query: 245 AWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQR 304
++P N +++ D+ + +W V+TG+ +S +H D +++V +N G V+G
Sbjct: 132 NFNPPSNLIISGSFDETVK--IWEVKTGKCLKTLS-AHSDPVSAVHFNCSGSLIVSGSYD 188
Query: 305 GQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDH 364
G L W+ QCL + +V +D+
Sbjct: 189 G----------LCRIWDAASGQCL----------------------------KTLVDDDN 210
Query: 365 PIMSFT-ISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFI 423
P +SF S NG+ L + LWD ++ Y G Y I + F +I
Sbjct: 211 PPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWI 270
Query: 424 ASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASAS--DDGTVRIW 478
SGSED+ VYIW+ +++ + +L GHT V + +P +++ASA+ +D T+++W
Sbjct: 271 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHP-TENLIASAALENDKTIKLW 326
Score = 43.1 bits (100), Expect = 6e-04
Identities = 32/121 (26%), Positives = 52/121 (42%), Gaps = 6/121 (4%)
Query: 359 IVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGF-YTIHSCFGG 417
+V + S S NG + A + + +W D KY+ G I
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDG----KYEKTLYGHNLEISDVAWS 92
Query: 418 HNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRI 477
+ + S S+D + +W RS + L GH+ V C ++NP +++ S S D TV+I
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPP-SNLIISGSFDETVKI 151
Query: 478 W 478
W
Sbjct: 152 W 152
Score = 40.8 bits (94), Expect = 0.003
Identities = 41/169 (24%), Positives = 71/169 (42%), Gaps = 23/169 (13%)
Query: 313 DGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTIS 372
+G L S R+ +W DGK + + G+N E ++D + ++S +
Sbjct: 52 NGEWLASSSADRLIIIWGAYDGKY------EKTLYGHNLE-ISDVAWSSDSSRLVSASDD 104
Query: 373 KNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKV 432
K + LWD++ ++ +G + + C + I SGS D V
Sbjct: 105 KT------------LKLWDVRSGKCLKTLKGHSN---YVFCCNFNPPSNLIISGSFDETV 149
Query: 433 YIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPA 481
IW ++ + L+ H+ V+ V +N S++ S S DG RIW A
Sbjct: 150 KIWEVKTGKCLKTLSAHSDPVSAVHFNCS-GSLIVSGSYDGLCRIWDAA 197
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 86.7 bits (213), Expect = 5e-17
Identities = 83/317 (26%), Positives = 132/317 (41%), Gaps = 39/317 (12%)
Query: 196 WFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVA 255
WF ++ GT LA+ D + IW + D+ + K + + EGH V +AWSP NYL +
Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLS-EGHQRTVRKVAWSPCGNYLAS 78
Query: 256 CGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGN 315
D + +W N E T + + HE+ + SVAW P G T + + ++D
Sbjct: 79 ASFDATTCIWKKNQDDFECVTTL-EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEE 137
Query: 316 LLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTI-SKN 374
D +E V V D K V+ + + + +++D +ED + T+
Sbjct: 138 --DEYECVSVLNSH-TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHE 194
Query: 375 GRLALLNVATQGVHLWDLQDRVLVRKY--------QGVT--------------QGFY--T 410
+ L G L D VR + QGV GF+ T
Sbjct: 195 STVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRT 254
Query: 411 IHSCFGGHNEDFIASGSEDHKVYIW----HKRSELPIAELT-----GHTRTVNCVSWNPQ 461
I+ +A+ D + ++ + + P LT H++ VNCV+WNP+
Sbjct: 255 IYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPK 314
Query: 462 IPSMMASASDDGTVRIW 478
P ++AS SDDG V W
Sbjct: 315 EPGLLASCSDDGEVAFW 331
Score = 56.2 bits (134), Expect = 7e-08
Identities = 36/112 (32%), Positives = 53/112 (47%), Gaps = 7/112 (6%)
Query: 185 QQILTE-HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSY 243
+ +L+E H V +S G LA+ S D T IW+ + D + + TLEGH V
Sbjct: 53 KSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDD--FECVTTLEGHENEVKS 110
Query: 244 IAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMS--QSHEDSLTSVAWNP 293
+AW+P N L C D +W+W V + +S SH + V W+P
Sbjct: 111 VAWAPSGNLLATCSRD--KSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHP 160
Score = 39.7 bits (91), Expect = 0.006
Identities = 36/127 (28%), Positives = 49/127 (38%), Gaps = 24/127 (18%)
Query: 188 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQ--------------VDPDTHLLKLLKT 233
L H + VW F G +LA+ S D TV IW+ DP K + T
Sbjct: 190 LEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPS---WKCICT 246
Query: 234 LEG-HAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQ------TGELRTKMSQSHEDSL 286
L G H+ + IAW L DD ++ + T L + Q+H +
Sbjct: 247 LSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDV 306
Query: 287 TSVAWNP 293
VAWNP
Sbjct: 307 NCVAWNP 313
Score = 35.8 bits (81), Expect = 0.093
Identities = 25/98 (25%), Positives = 43/98 (43%), Gaps = 4/98 (4%)
Query: 168 SLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHL 227
S+ + V ++ C + +L H +V + LA+ S D TV +++ + D +
Sbjct: 128 SVWVWEVDEEDEYECVS--VLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWV 185
Query: 228 LKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELW 265
TLEGH V +A+ P L +C D +W
Sbjct: 186 C--CATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Score = 32.3 bits (72), Expect = 1.0
Identities = 21/72 (29%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Query: 207 LATGSKDTTVIIWQVDPDTHLLKLLKTL-----EGHAYGVSYIAWSPDDNYLVACGPDDC 261
LAT D + ++Q DP++ + +L + H+ V+ +AW+P + L+A DD
Sbjct: 267 LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDD- 325
Query: 262 SELWLWNVQTGE 273
E+ W Q E
Sbjct: 326 GEVAFWKYQRPE 337
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 82.4 bits (202), Expect = 9e-16
Identities = 78/317 (24%), Positives = 135/317 (42%), Gaps = 40/317 (12%)
Query: 175 CSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQV--DPDTHLLKLLK 232
CS Q P +L+ H EV+ CKF +G+ LA+ D +++W V D D +
Sbjct: 52 CSSLQAPI---MLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYA----- 103
Query: 233 TLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWN 292
TL+GH+ V + ++ D + L + D + +W+ +TGE R K + H + S
Sbjct: 104 TLKGHSGAVMELHYNTDGSMLFSASTD--KTVAVWDSETGE-RVKRLKGHTSFVNSCYPA 160
Query: 293 PDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLA---SDTHQRIRGY 349
G + V G D + W+ + + + VLA +DT +I
Sbjct: 161 RRGPQLVCTGS---------DDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISG 211
Query: 350 NFE------DLTDRNIVQ----EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRV--- 396
+ DL + + ++S G L N V +WD++
Sbjct: 212 GIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKE 271
Query: 397 -LVRKYQGVTQGFY-TIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVN 454
V+ +QG F + C + IA+GS D VY+W S + +L GH ++N
Sbjct: 272 RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331
Query: 455 CVSWNPQIPSMMASASD 471
V+++P P +++++SD
Sbjct: 332 EVAFHPDEPIIISASSD 348
Score = 48.1 bits (113), Expect = 2e-05
Identities = 56/250 (22%), Positives = 95/250 (38%), Gaps = 44/250 (17%)
Query: 234 LEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNP 293
L GH V + P+ + L + G D + LWNV + H ++ + +N
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRL--ILLWNVYGDCDNYATLKGHSGAVMELHYNT 119
Query: 294 DGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFED 353
DG + D + DS G RV+ L G T + + RG
Sbjct: 120 DGSMLFSAST-------DKTVAVWDSETGERVKRL----KGHTSFVNSCYPARRG----- 163
Query: 354 LTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHS 413
P + T S +G V LWD++ + ++ +Q Y + +
Sbjct: 164 -----------PQLVCTGSDDGT----------VKLWDIRKKAAIQTFQNT----YQVLA 198
Query: 414 CFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDG 473
D I SG D+ + +W R + GH +V +S + + ++++A D+
Sbjct: 199 VTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDN- 257
Query: 474 TVRIWGPAPF 483
TVR+W PF
Sbjct: 258 TVRVWDVRPF 267
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 81.6 bits (200), Expect = 1e-15
Identities = 76/303 (25%), Positives = 134/303 (44%), Gaps = 25/303 (8%)
Query: 188 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDT-HLLKLLKTLEGHAYGVSYIAW 246
L H V FS G LA+GS DTTV W + +T H T +GH + V I+W
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHF-----TCKGHRHWVLSISW 164
Query: 247 SPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAW-----NPDGKRFVTG 301
SPD L + + ++ LW+ TG+ + H +T ++W NP+ + +
Sbjct: 165 SPDGRKLASGCKN--GQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASS 222
Query: 302 GQRGQFYQCDLDGNLLDSWEGVRVQCLWCLS-DGKTVLASDTHQR-IRGYNFED-LTDRN 358
+ G D + Q + CL G +L S + R I+ + D + R
Sbjct: 223 SKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRT 282
Query: 359 IVQEDHPIMSFTISKNG--RLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFG 416
+ H + + +S + R A V+ DLQ + K + +++ ++
Sbjct: 283 LQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSR-----YNLVR 337
Query: 417 GHNEDFIASGSEDHKVYIWH-KRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTV 475
G + + SGS+D +++W + P+ +TGH +N V ++P ++ASAS D ++
Sbjct: 338 GQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD-SRIVASASFDKSI 396
Query: 476 RIW 478
++W
Sbjct: 397 KLW 399
Score = 62.4 bits (150), Expect = 9e-10
Identities = 80/340 (23%), Positives = 138/340 (40%), Gaps = 63/340 (18%)
Query: 191 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAW---- 246
H + V +S DG KLA+G K+ +++W DP T ++ +TL GH+ ++ ++W
Sbjct: 155 HRHWVLSISWSPDGRKLASGCKNGQILLW--DPSTGK-QVGRTLAGHSKWITGLSWEPLH 211
Query: 247 -SPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRG 305
+P+ Y+ + D + +W+ G ++ H S+T + W DG + R
Sbjct: 212 ANPECRYVASSSKD--GSVRIWDTTAGRCE-RILTGHTQSVTCLRWGGDGLLYSASQDRT 268
Query: 306 QFYQCDLDGNLLDSWEG----VRVQCL---WCLSDG--KTVLASDTHQRIRGYNFEDLTD 356
DG L + +G V L + L G + AS Q ++G + ++L +
Sbjct: 269 IKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQG-SLQELKE 327
Query: 357 R-----NIVQEDHPIM------SFTI-------------SKNGRLALLN----------V 382
R N+V+ P FT+ G AL+N V
Sbjct: 328 RALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIV 387
Query: 383 AT----QGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKR 438
A+ + + LWD + + +G Y I + + SGS D + +W +
Sbjct: 388 ASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIA---WSADSRLLVSGSSDSTLKVWDVK 444
Query: 439 SELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
++ +L GH V V W+P +AS D +RIW
Sbjct: 445 AQKLAMDLPGHADEVYAVDWSPD-GQRVASGGKDKCLRIW 483
Score = 48.9 bits (115), Expect = 1e-05
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 188 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWS 247
L H V+ +S D L +GS D+T+ +W V KL L GHA V + WS
Sbjct: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ----KLAMDLPGHADEVYAVDWS 465
Query: 248 PDDNYLVACGPDDCSELW 265
PD + + G D C +W
Sbjct: 466 PDGQRVASGGKDKCLRIW 483
Score = 40.4 bits (93), Expect = 0.004
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Query: 422 FIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPA 481
++ASGS D V W +E P GH V +SW+P +AS +G + +W P+
Sbjct: 128 YLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPD-GRKLASGCKNGQILLWDPS 186
Score = 30.8 bits (68), Expect = 3.0
Identities = 13/33 (39%), Positives = 21/33 (63%)
Query: 188 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQ 220
L H +EV+ +S DG ++A+G KD + IW+
Sbjct: 452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
Length = 1298
Score = 77.8 bits (190), Expect = 2e-14
Identities = 68/292 (23%), Positives = 115/292 (39%), Gaps = 50/292 (17%)
Query: 191 HCNEVWFCKFS-NDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPD 249
H ++ CKF +D LAT S D T+ +W D + L + T G+ + ++W+P
Sbjct: 368 HVETIFDCKFKPDDPNLLATASFDGTIKVW----DINTLTAVYTSPGNEGVIYSLSWAPG 423
Query: 250 DNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWN-PDGKRFVTGGQRGQFY 308
+A G + ++WNVQ G++ + ++ + + +AW+ D KR T G
Sbjct: 424 GLNCIAGGTSR-NGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI 482
Query: 309 QCDLDGNLLDSWE--GVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPI 366
+DG +L ++ C W ++ + +R Y D P+
Sbjct: 483 IRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVA-------TSSDQPL 535
Query: 367 MSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASG 426
F+ G A + H + E + SG
Sbjct: 536 KVFS----GHTAKV------------------------------FHVKWSPLREGILCSG 561
Query: 427 SEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
S+D V IW + I L GHT V + WN +IP ++ S S D T+++W
Sbjct: 562 SDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVW 613
Score = 37.7 bits (86), Expect = 0.024
Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 4/54 (7%)
Query: 432 VYIW---HKRSELPI-AELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPA 481
+YI+ H+ +E + A ++ H +T+ +SW P P + AS S D V IW A
Sbjct: 37 IYIYQLDHRYNEFKLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVA 90
Score = 37.7 bits (86), Expect = 0.024
Identities = 21/61 (34%), Positives = 29/61 (47%)
Query: 418 HNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRI 477
HN D ASGS D+ V IW+ + IA+L +SW ++A S G + I
Sbjct: 70 HNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAFVSHRGPLFI 129
Query: 478 W 478
W
Sbjct: 130 W 130
Score = 29.6 bits (65), Expect = 6.6
Identities = 20/76 (26%), Positives = 38/76 (50%), Gaps = 2/76 (2%)
Query: 216 VIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELR 275
+ I+Q+D + KL + H ++ I+W P + L A G D + + +WNV ++
Sbjct: 37 IYIYQLDHRYNEFKLHAIMSEHKKTITAISWCPHNPDLFASGSTD-NLVIIWNVAEQKVI 95
Query: 276 TKMSQSHEDSLTSVAW 291
K+ S + S++W
Sbjct: 96 AKL-DSTKGIPASLSW 110
>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
Length = 1322
Score = 77.8 bits (190), Expect = 2e-14
Identities = 68/292 (23%), Positives = 115/292 (39%), Gaps = 50/292 (17%)
Query: 191 HCNEVWFCKFS-NDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPD 249
H ++ CKF +D LAT S D T+ +W D + L + T G+ + ++W+P
Sbjct: 392 HVETIFDCKFKPDDPNLLATASFDGTIKVW----DINTLTAVYTSPGNEGVIYSLSWAPG 447
Query: 250 DNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWN-PDGKRFVTGGQRGQFY 308
+A G + ++WNVQ G++ + ++ + + +AW+ D KR T G
Sbjct: 448 GLNCIAGGTSR-NGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI 506
Query: 309 QCDLDGNLLDSWE--GVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPI 366
+DG +L ++ C W ++ + +R Y D P+
Sbjct: 507 IRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVA-------TSSDQPL 559
Query: 367 MSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASG 426
F+ G A + H + E + SG
Sbjct: 560 KVFS----GHTAKV------------------------------FHVKWSPLREGILCSG 585
Query: 427 SEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
S+D V IW + I L GHT V + WN +IP ++ S S D T+++W
Sbjct: 586 SDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVW 637
Score = 37.7 bits (86), Expect = 0.024
Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 4/54 (7%)
Query: 432 VYIW---HKRSELPI-AELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPA 481
+YI+ H+ +E + A ++ H +T+ +SW P P + AS S D V IW A
Sbjct: 61 IYIYQLDHRYNEFKLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVA 114
Score = 37.7 bits (86), Expect = 0.024
Identities = 21/61 (34%), Positives = 29/61 (47%)
Query: 418 HNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRI 477
HN D ASGS D+ V IW+ + IA+L +SW ++A S G + I
Sbjct: 94 HNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAFVSHRGPLFI 153
Query: 478 W 478
W
Sbjct: 154 W 154
Score = 29.6 bits (65), Expect = 6.6
Identities = 20/76 (26%), Positives = 38/76 (50%), Gaps = 2/76 (2%)
Query: 216 VIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELR 275
+ I+Q+D + KL + H ++ I+W P + L A G D + + +WNV ++
Sbjct: 61 IYIYQLDHRYNEFKLHAIMSEHKKTITAISWCPHNPDLFASGSTD-NLVIIWNVAEQKVI 119
Query: 276 TKMSQSHEDSLTSVAW 291
K+ S + S++W
Sbjct: 120 AKL-DSTKGIPASLSW 134
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 74.7 bits (182), Expect = 2e-13
Identities = 83/305 (27%), Positives = 118/305 (38%), Gaps = 72/305 (23%)
Query: 201 SNDGTKLATGSKDTTVIIWQVDP---------------------------DTHLLKLLKT 233
++D + +A G D+TV +W V P D LK
Sbjct: 479 TDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKI 538
Query: 234 LEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNP 293
L GH+ V ++SPD NYL++ D LW T + K H + ++P
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK---GHNYPVWDTQFSP 595
Query: 294 DGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFED 353
G FV+GG RV LW A+D +Q +R +
Sbjct: 596 YGYYFVSGGHD-------------------RVARLW---------ATDHYQPLRIFAGH- 626
Query: 354 LTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHS 413
L D N + HP N A + V LWD+ + VR + G IHS
Sbjct: 627 LADVNCTRF-HP--------NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG---PIHS 674
Query: 414 CFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDG 473
N F+A+G+ D +V +W L + EL GHT TV C + ++AS S D
Sbjct: 675 LTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTV-CSLRFSRDGEILASGSMDN 733
Query: 474 TVRIW 478
TVR+W
Sbjct: 734 TVRLW 738
Score = 57.8 bits (138), Expect = 2e-08
Identities = 61/250 (24%), Positives = 93/250 (37%), Gaps = 48/250 (19%)
Query: 186 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIA 245
+IL H V+ FS D L + S+D TV +W + T L+ +GH Y V
Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV----GYKGHNYPVWDTQ 592
Query: 246 WSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRG 305
+SP Y V+ G D + LW + ++ H + ++P+ TG
Sbjct: 593 FSPYGYYFVSGGHDRVARLWATDHYQ---PLRIFAGHLADVNCTRFHPNSNYVATG---- 645
Query: 306 QFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHP 365
R LW + +G V H+ P
Sbjct: 646 ---------------SADRTVRLWDVLNGNCVRIFTGHK-------------------GP 671
Query: 366 IMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIAS 425
I S T S NGR V LWD+ ++V + +G T T+ S + + +AS
Sbjct: 672 IHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD---TVCSLRFSRDGEILAS 728
Query: 426 GSEDHKVYIW 435
GS D+ V +W
Sbjct: 729 GSMDNTVRLW 738
Score = 30.4 bits (67), Expect = 3.9
Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 3/45 (6%)
Query: 439 SELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPAPF 483
SEL I L GH+ V S++P + + S+S+DGTVR+W F
Sbjct: 534 SELKI--LYGHSGPVYGASFSPD-RNYLLSSSEDGTVRLWSLQTF 575
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 68.2 bits (165), Expect = 2e-11
Identities = 74/292 (25%), Positives = 117/292 (40%), Gaps = 50/292 (17%)
Query: 188 LTEHCNEVWFCKFSND-GTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAW 246
L H N V+ F+N G K+ATGS D T +W V+ K T GH + +++
Sbjct: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG----KCYHTFRGHTAEIVCLSF 185
Query: 247 SPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQ 306
+P LVA G D + LW++Q GE + H + S+++N G R +TG
Sbjct: 186 NPQST-LVATGSMDTTAK-LWDIQNGE-EVYTLRGHSAEIISLSFNTSGDRIITGS---- 238
Query: 307 FYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPI 366
D ++ +W G+ V ++ I
Sbjct: 239 -----FDHTVV----------VWDADTGRKV-------------------NILIGHCAEI 264
Query: 367 MSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASG 426
S + + + L L + LWD + V G + SCF + IA+
Sbjct: 265 SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI--LDSCFD-YTGKLIATA 321
Query: 427 SEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
S D I+ + IA+L GH ++ +S+NPQ + + + S D T RIW
Sbjct: 322 SADGTARIFSAATRKCIAKLEGHEGEISKISFNPQ-GNHLLTGSSDKTARIW 372
Score = 48.5 bits (114), Expect = 1e-05
Identities = 35/127 (27%), Positives = 56/127 (44%), Gaps = 9/127 (7%)
Query: 365 PIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIA 424
P+ + ++K+G + + LWD + +G Y I F D IA
Sbjct: 94 PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI--AFNNPYGDKIA 151
Query: 425 SGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPAPFI 484
+GS D +W + GHT + C+S+NPQ +++A+ S D T ++W
Sbjct: 152 TGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ-STLVATGSMDTTAKLW------ 204
Query: 485 DHQNIEE 491
D QN EE
Sbjct: 205 DIQNGEE 211
Score = 36.2 bits (82), Expect = 0.071
Identities = 15/35 (42%), Positives = 22/35 (62%)
Query: 186 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQ 220
Q+L H +E++ C F+ G + TGSKD T IW+
Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 66.2 bits (160), Expect = 6e-11
Identities = 69/282 (24%), Positives = 117/282 (41%), Gaps = 48/282 (17%)
Query: 191 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDD 250
H V FC+FS DG A+ S D TV +W D K L+ L+GH V +++SPD
Sbjct: 62 HTGPVKFCRFSPDGHLFASASCDCTVRLW----DVARAKCLRVLKGHQRSVETVSFSPDS 117
Query: 251 NYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQC 310
L + G D + LW+VQ+G++ ++ H DS+ S ++P TG
Sbjct: 118 RQLASGGWD--KRVMLWDVQSGQM-LRLLVGHRDSIQSSDFSPTVNCLATG--------- 165
Query: 311 DLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFT 370
SW+ +W D + V + +HQ + G++ I
Sbjct: 166 --------SWDS--TVHIW---DLRMVTPAVSHQALEGHSAN-------------ISCLC 199
Query: 371 ISKNGRLALLNVATQGVHLWDLQDRVLVRKYQG-VTQGFYTIHSCFGGHNEDFIASGSED 429
S +G LA + +H+W L+ + +G VT + S +E ++AS
Sbjct: 200 YSASGLLA-SGSWDKTIHIWKPTTSSLLIQLKGHVT----WVKSIAFSPDELWLASAGYS 254
Query: 430 HKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASD 471
V +W + + L G + ++ P +++ A+D
Sbjct: 255 RMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
Score = 62.4 bits (150), Expect = 9e-10
Identities = 63/261 (24%), Positives = 104/261 (39%), Gaps = 49/261 (18%)
Query: 223 PDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSH 282
P T ++ +K H V+ A+SPD L+ D C ++ W ++G+L ++ H
Sbjct: 6 PATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGC--VYGWETRSGQLLWRLG-GH 62
Query: 283 EDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDT 342
+ ++PDG F + CD L W+ R +CL L
Sbjct: 63 TGPVKFCRFSPDGHLFASA-------SCDCTVRL---WDVARAKCLRVLKG--------- 103
Query: 343 HQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQ 402
HQR + + + S + R + V LWD+Q ++R
Sbjct: 104 HQR-------------------SVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLV 144
Query: 403 GVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAE---LTGHTRTVNCVSWN 459
G +I S + +A+GS D V+IW R P L GH+ ++C+ ++
Sbjct: 145 GHRD---SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYS 201
Query: 460 PQIPSMMASASDDGTVRIWGP 480
++AS S D T+ IW P
Sbjct: 202 AS--GLLASGSWDKTIHIWKP 220
Score = 41.6 bits (96), Expect = 0.002
Identities = 26/110 (23%), Positives = 48/110 (43%), Gaps = 4/110 (3%)
Query: 186 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIA 245
++L H V FS D +LA+G D V++W V ++L+ L GH +
Sbjct: 99 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG----QMLRLLVGHRDSIQSSD 154
Query: 246 WSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDG 295
+SP N L D +W + T + + + H +++ + ++ G
Sbjct: 155 FSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG 204
Score = 40.8 bits (94), Expect = 0.003
Identities = 25/59 (42%), Positives = 32/59 (54%), Gaps = 1/59 (1%)
Query: 423 IASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPA 481
+ +GSED VY W RS + L GHT V ++P + ASAS D TVR+W A
Sbjct: 36 LLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD-GHLFASASCDCTVRLWDVA 93
>gi|109627650 coronin 6 [Homo sapiens]
Length = 472
Score = 66.2 bits (160), Expect = 6e-11
Identities = 34/98 (34%), Positives = 56/98 (57%), Gaps = 6/98 (6%)
Query: 207 LATGSKDTTVIIWQVD---PDTHLLKLLKTLEGHAYGVSYIAWSPDD-NYLVACGPDDCS 262
+A+ S DTT+++WQ+ P ++ + + TLEGH+ V ++W P N L++ G D+
Sbjct: 97 IASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNV- 155
Query: 263 ELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVT 300
+ +WNV TGE+ + H D + SV WN +G T
Sbjct: 156 -IIIWNVGTGEVLLSLDDMHPDVIHSVCWNSNGSLLAT 192
Score = 48.1 bits (113), Expect = 2e-05
Identities = 22/68 (32%), Positives = 36/68 (52%), Gaps = 7/68 (10%)
Query: 418 HNEDFIASGSEDHKVYIWH-------KRSELPIAELTGHTRTVNCVSWNPQIPSMMASAS 470
HN++ IAS S+D + +W + PI L GH++ V +SW+P +++ SA
Sbjct: 92 HNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAG 151
Query: 471 DDGTVRIW 478
D + IW
Sbjct: 152 GDNVIIIW 159
Score = 40.4 bits (93), Expect = 0.004
Identities = 18/52 (34%), Positives = 30/52 (57%)
Query: 446 LTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPAPFIDHQNIEEECSSMD 497
+TGHT V + W P +++ASASDD T+ +W + +NI E +++
Sbjct: 77 VTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLE 128
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 65.9 bits (159), Expect = 8e-11
Identities = 84/363 (23%), Positives = 140/363 (38%), Gaps = 70/363 (19%)
Query: 190 EHCNEVWFCKFSNDGTKL--ATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWS 247
EH +V C F+N L ATGS D + +W D + + T+ GH V++ +S
Sbjct: 697 EHSEQVNCCHFTNSSHHLLLATGSSDCFLKLW----DLNQKECRNTMFGHTNSVNHCRFS 752
Query: 248 PDDNYLVACGPDDCSELW-------LWNVQTGELRTKMSQSHEDSLTSV---AWNPDGKR 297
PDD L +C D +LW ++ + + ED V +W+ DG R
Sbjct: 753 PDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGAR 812
Query: 298 FVTGGQRGQF-YQCDLDGNLLD-----SWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNF 351
+ + F + D + D SW V + DG + L S Q IR +
Sbjct: 813 IMVAAKNKIFLWNTDSRSKVADCRGHLSW----VHGVMFSPDGSSFLTSSDDQTIRLWET 868
Query: 352 EDL---------TDRNIVQEDHPIMSFTISKNGRLALLNVATQGV--------------- 387
+ + + ++V +++ +M + RL L+N T +
Sbjct: 869 KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 928
Query: 388 HLW-----------DLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWH 436
HL ++ + V R +Q Q T+ +E + S S+D ++ +W+
Sbjct: 929 HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 988
Query: 437 KRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWG------PAPFIDHQNIE 490
+ + I L GH TV + S + S S DGTV++W F+ HQ
Sbjct: 989 WQLDKCIF-LRGHQETVK--DFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTV 1045
Query: 491 EEC 493
C
Sbjct: 1046 LSC 1048
Score = 63.5 bits (153), Expect = 4e-10
Identities = 69/294 (23%), Positives = 124/294 (42%), Gaps = 26/294 (8%)
Query: 191 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDD 250
H + V FS DG+ T S D T+ +W+ + K + V + +
Sbjct: 838 HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK---VCKNSAVMLKQEVDVVF-----QE 889
Query: 251 NYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQC 310
N ++ D L L N +TG++ E ++ +P + G + G
Sbjct: 890 NEVMVLAVDHIRRLQLINGRTGQI----DYLTEAQVSCCCLSPHLQYIAFGDENGAIEIL 945
Query: 311 DLDGNLLDSWEGVRVQCLWCL---SDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHP-- 365
+L N + + +W + +D KT+++S I+ +N++ D+ I H
Sbjct: 946 ELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQ--LDKCIFLRGHQET 1003
Query: 366 IMSFTISKNGRLALLNVATQG-VHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIA 424
+ F + KN RL L+ + G V +W++ + K + T+ SC H+ +
Sbjct: 1004 VKDFRLLKNSRL--LSWSFDGTVKVWNI---ITGNKEKDFVCHQGTVLSCDISHDATKFS 1058
Query: 425 SGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
S S D IW LP+ EL GH V C +++ +++A+ D+G +RIW
Sbjct: 1059 STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD-STLLATGDDNGEIRIW 1111
Score = 56.6 bits (135), Expect = 5e-08
Identities = 64/327 (19%), Positives = 129/327 (39%), Gaps = 38/327 (11%)
Query: 154 LYHNTKLD--NNLDSVSLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGS 211
+Y KL +D+ L ++ + +++ ++ ++ H + V+ FS DG ++A+
Sbjct: 576 VYQQAKLQAKQEVDNGMLYLEWI-NKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCG 634
Query: 212 KDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQT 271
D T+ +++ + LL++ + H V A+S DD ++ C D ++ +WN T
Sbjct: 635 ADKTLQVFKAETGEKLLEI----KAHEDEVLCCAFSTDDRFIATCSVD--KKVKIWNSMT 688
Query: 272 GELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCL 331
GEL + E N + G F L W+ + +C
Sbjct: 689 GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF---------LKLWDLNQKEC---- 735
Query: 332 SDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWD 391
R + + + D +++ + S +G L L + AT
Sbjct: 736 -------------RNTMFGHTNSVNHCRFSPDDKLLA-SCSADGTLKLWD-ATSANERKS 780
Query: 392 LQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTR 451
+ + + + I C + + +K+++W+ S +A+ GH
Sbjct: 781 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLS 840
Query: 452 TVNCVSWNPQIPSMMASASDDGTVRIW 478
V+ V ++P S + S SDD T+R+W
Sbjct: 841 WVHGVMFSPDGSSFLTS-SDDQTIRLW 866
Score = 44.3 bits (103), Expect = 3e-04
Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 11/114 (9%)
Query: 200 FSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTL--EG---HAYGVSYIAWSPDDNYLV 254
FS D T LATG + + IW V + LL L L EG H V+ + +SPD L+
Sbjct: 1092 FSVDSTLLATGDDNGEIRIWNVS-NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1150
Query: 255 ACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFY 308
+ G + WNV TGE ++ ++ +L + +PD K +VT G Y
Sbjct: 1151 SAG----GYIKWWNVVTGE-SSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILY 1199
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 65.9 bits (159), Expect = 8e-11
Identities = 84/363 (23%), Positives = 140/363 (38%), Gaps = 70/363 (19%)
Query: 190 EHCNEVWFCKFSNDGTKL--ATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWS 247
EH +V C F+N L ATGS D + +W D + + T+ GH V++ +S
Sbjct: 686 EHSEQVNCCHFTNSSHHLLLATGSSDCFLKLW----DLNQKECRNTMFGHTNSVNHCRFS 741
Query: 248 PDDNYLVACGPDDCSELW-------LWNVQTGELRTKMSQSHEDSLTSV---AWNPDGKR 297
PDD L +C D +LW ++ + + ED V +W+ DG R
Sbjct: 742 PDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGAR 801
Query: 298 FVTGGQRGQF-YQCDLDGNLLD-----SWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNF 351
+ + F + D + D SW V + DG + L S Q IR +
Sbjct: 802 IMVAAKNKIFLWNTDSRSKVADCRGHLSW----VHGVMFSPDGSSFLTSSDDQTIRLWET 857
Query: 352 EDL---------TDRNIVQEDHPIMSFTISKNGRLALLNVATQGV--------------- 387
+ + + ++V +++ +M + RL L+N T +
Sbjct: 858 KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 917
Query: 388 HLW-----------DLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWH 436
HL ++ + V R +Q Q T+ +E + S S+D ++ +W+
Sbjct: 918 HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 977
Query: 437 KRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWG------PAPFIDHQNIE 490
+ + I L GH TV + S + S S DGTV++W F+ HQ
Sbjct: 978 WQLDKCIF-LRGHQETVK--DFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTV 1034
Query: 491 EEC 493
C
Sbjct: 1035 LSC 1037
Score = 63.5 bits (153), Expect = 4e-10
Identities = 69/294 (23%), Positives = 124/294 (42%), Gaps = 26/294 (8%)
Query: 191 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDD 250
H + V FS DG+ T S D T+ +W+ + K + V + +
Sbjct: 827 HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK---VCKNSAVMLKQEVDVVF-----QE 878
Query: 251 NYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQC 310
N ++ D L L N +TG++ E ++ +P + G + G
Sbjct: 879 NEVMVLAVDHIRRLQLINGRTGQI----DYLTEAQVSCCCLSPHLQYIAFGDENGAIEIL 934
Query: 311 DLDGNLLDSWEGVRVQCLWCL---SDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHP-- 365
+L N + + +W + +D KT+++S I+ +N++ D+ I H
Sbjct: 935 ELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQ--LDKCIFLRGHQET 992
Query: 366 IMSFTISKNGRLALLNVATQG-VHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIA 424
+ F + KN RL L+ + G V +W++ + K + T+ SC H+ +
Sbjct: 993 VKDFRLLKNSRL--LSWSFDGTVKVWNI---ITGNKEKDFVCHQGTVLSCDISHDATKFS 1047
Query: 425 SGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
S S D IW LP+ EL GH V C +++ +++A+ D+G +RIW
Sbjct: 1048 STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD-STLLATGDDNGEIRIW 1100
Score = 56.6 bits (135), Expect = 5e-08
Identities = 64/327 (19%), Positives = 129/327 (39%), Gaps = 38/327 (11%)
Query: 154 LYHNTKLD--NNLDSVSLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGS 211
+Y KL +D+ L ++ + +++ ++ ++ H + V+ FS DG ++A+
Sbjct: 565 VYQQAKLQAKQEVDNGMLYLEWI-NKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCG 623
Query: 212 KDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQT 271
D T+ +++ + LL++ + H V A+S DD ++ C D ++ +WN T
Sbjct: 624 ADKTLQVFKAETGEKLLEI----KAHEDEVLCCAFSTDDRFIATCSVD--KKVKIWNSMT 677
Query: 272 GELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCL 331
GEL + E N + G F L W+ + +C
Sbjct: 678 GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF---------LKLWDLNQKEC---- 724
Query: 332 SDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWD 391
R + + + D +++ + S +G L L + AT
Sbjct: 725 -------------RNTMFGHTNSVNHCRFSPDDKLLA-SCSADGTLKLWD-ATSANERKS 769
Query: 392 LQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTR 451
+ + + + I C + + +K+++W+ S +A+ GH
Sbjct: 770 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLS 829
Query: 452 TVNCVSWNPQIPSMMASASDDGTVRIW 478
V+ V ++P S + S SDD T+R+W
Sbjct: 830 WVHGVMFSPDGSSFLTS-SDDQTIRLW 855
Score = 44.3 bits (103), Expect = 3e-04
Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 11/114 (9%)
Query: 200 FSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTL--EG---HAYGVSYIAWSPDDNYLV 254
FS D T LATG + + IW V + LL L L EG H V+ + +SPD L+
Sbjct: 1081 FSVDSTLLATGDDNGEIRIWNVS-NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1139
Query: 255 ACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFY 308
+ G + WNV TGE ++ ++ +L + +PD K +VT G Y
Sbjct: 1140 SAG----GYIKWWNVVTGE-SSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILY 1188
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 65.5 bits (158), Expect = 1e-10
Identities = 72/303 (23%), Positives = 132/303 (43%), Gaps = 37/303 (12%)
Query: 186 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIA 245
++L H + V C G ++ +GS D T+ +W K L+TL GH GV
Sbjct: 256 KVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTG----KCLRTLVGHTGGV---- 306
Query: 246 WSPD--DNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQ 303
WS DN +++ D L +WN +TGE + + + T + KR V+G +
Sbjct: 307 WSSQMRDNIIISGSTD--RTLKVWNAETGEC---IHTLYGHTSTVRCMHLHEKRVVSGSR 361
Query: 304 RGQFYQCDLD-GNLLDSWEGVRVQCLWCLS-DGKTVLASDTHQRIRGYNFEDLTDRNIVQ 361
D++ G L G V + C+ DG+ V++ ++ ++ E T + +Q
Sbjct: 362 DATLRVWDIETGQCLHVLMG-HVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQ 420
Query: 362 EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRK---YQGVTQGFYTIHSCFGGH 418
H +++ +G + + +WD++ + +Q +T G
Sbjct: 421 -GHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL-------- 471
Query: 419 NEDFIASGSEDHKVYIWHKRSELPIAELTG---HTRTVNCVSWNPQIPSMMASASDDGTV 475
++ + SG+ D V IW ++ + L G H V C+ +N + + ++SDDGTV
Sbjct: 472 KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK---NFVITSSDDGTV 528
Query: 476 RIW 478
++W
Sbjct: 529 KLW 531
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 65.5 bits (158), Expect = 1e-10
Identities = 72/303 (23%), Positives = 132/303 (43%), Gaps = 37/303 (12%)
Query: 186 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIA 245
++L H + V C G ++ +GS D T+ +W K L+TL GH GV
Sbjct: 374 KVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTG----KCLRTLVGHTGGV---- 424
Query: 246 WSPD--DNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQ 303
WS DN +++ D L +WN +TGE + + + T + KR V+G +
Sbjct: 425 WSSQMRDNIIISGSTD--RTLKVWNAETGEC---IHTLYGHTSTVRCMHLHEKRVVSGSR 479
Query: 304 RGQFYQCDLD-GNLLDSWEGVRVQCLWCLS-DGKTVLASDTHQRIRGYNFEDLTDRNIVQ 361
D++ G L G V + C+ DG+ V++ ++ ++ E T + +Q
Sbjct: 480 DATLRVWDIETGQCLHVLMG-HVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQ 538
Query: 362 EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRK---YQGVTQGFYTIHSCFGGH 418
H +++ +G + + +WD++ + +Q +T G
Sbjct: 539 -GHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL-------- 589
Query: 419 NEDFIASGSEDHKVYIWHKRSELPIAELTG---HTRTVNCVSWNPQIPSMMASASDDGTV 475
++ + SG+ D V IW ++ + L G H V C+ +N + + ++SDDGTV
Sbjct: 590 KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK---NFVITSSDDGTV 646
Query: 476 RIW 478
++W
Sbjct: 647 KLW 649
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 65.5 bits (158), Expect = 1e-10
Identities = 72/303 (23%), Positives = 132/303 (43%), Gaps = 37/303 (12%)
Query: 186 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIA 245
++L H + V C G ++ +GS D T+ +W K L+TL GH GV
Sbjct: 294 KVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTG----KCLRTLVGHTGGV---- 344
Query: 246 WSPD--DNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQ 303
WS DN +++ D L +WN +TGE + + + T + KR V+G +
Sbjct: 345 WSSQMRDNIIISGSTD--RTLKVWNAETGEC---IHTLYGHTSTVRCMHLHEKRVVSGSR 399
Query: 304 RGQFYQCDLD-GNLLDSWEGVRVQCLWCLS-DGKTVLASDTHQRIRGYNFEDLTDRNIVQ 361
D++ G L G V + C+ DG+ V++ ++ ++ E T + +Q
Sbjct: 400 DATLRVWDIETGQCLHVLMG-HVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQ 458
Query: 362 EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRK---YQGVTQGFYTIHSCFGGH 418
H +++ +G + + +WD++ + +Q +T G
Sbjct: 459 -GHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL-------- 509
Query: 419 NEDFIASGSEDHKVYIWHKRSELPIAELTG---HTRTVNCVSWNPQIPSMMASASDDGTV 475
++ + SG+ D V IW ++ + L G H V C+ +N + + ++SDDGTV
Sbjct: 510 KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK---NFVITSSDDGTV 566
Query: 476 RIW 478
++W
Sbjct: 567 KLW 569
>gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo
sapiens]
Length = 474
Score = 65.5 bits (158), Expect = 1e-10
Identities = 35/101 (34%), Positives = 56/101 (55%), Gaps = 6/101 (5%)
Query: 207 LATGSKDTTVIIWQVDPDTHLLKLLKT---LEGHAYGVSYIAWSPDD-NYLVACGPDDCS 262
+A+GS+D TV++WQ+ + L L + LEGH+ V +AW P N L++ G D+
Sbjct: 96 IASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNA- 154
Query: 263 ELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQ 303
+ +WNV TGE + H D + +V+WN +G T +
Sbjct: 155 -IIIWNVGTGEALINLDDMHSDMIYNVSWNRNGSLICTASK 194
Score = 48.1 bits (113), Expect = 2e-05
Identities = 24/68 (35%), Positives = 35/68 (51%), Gaps = 7/68 (10%)
Query: 418 HNEDFIASGSEDHKVYIWHKRSE-------LPIAELTGHTRTVNCVSWNPQIPSMMASAS 470
HN+ IASGSED V +W P+ L GH++ V V+W+P +++ SA
Sbjct: 91 HNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAG 150
Query: 471 DDGTVRIW 478
D + IW
Sbjct: 151 CDNAIIIW 158
Score = 35.4 bits (80), Expect = 0.12
Identities = 19/74 (25%), Positives = 35/74 (47%), Gaps = 7/74 (9%)
Query: 229 KLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMS------QSH 282
K T+ GH V I W P ++ ++A G +DC+ + +W + L ++ + H
Sbjct: 71 KSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCT-VMVWQIPENGLTLSLTEPVVILEGH 129
Query: 283 EDSLTSVAWNPDGK 296
+ VAW+P +
Sbjct: 130 SKRVGIVAWHPTAR 143
Score = 33.5 bits (75), Expect = 0.46
Identities = 26/85 (30%), Positives = 35/85 (41%), Gaps = 7/85 (8%)
Query: 401 YQGVTQGFYTIHSCFGGHNEDFIA-----SGSEDHKVYIWHK--RSELPIAELTGHTRTV 453
Y + T S F N F+A SG V HK R + + GHT V
Sbjct: 24 YDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRIDKSYPTVCGHTGPV 83
Query: 454 NCVSWNPQIPSMMASASDDGTVRIW 478
+ W P ++AS S+D TV +W
Sbjct: 84 LDIDWCPHNDQVIASGSEDCTVMVW 108
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 65.1 bits (157), Expect = 1e-10
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 49/287 (17%)
Query: 191 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDD 250
H + V FS + +LA+GS D+ +++W + P + + GH V+ + +SP
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT----GHKDAVTCVNFSPSG 73
Query: 251 NYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQC 310
+ L + D +W+ NV+ GE + + ++H ++ SV + DG+ FVT
Sbjct: 74 HLLASGSRDKTVRIWVPNVK-GE--STVFRAHTATVRSVHFCSDGQSFVTA--------- 121
Query: 311 DLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFT 370
SD KTV TH++ ++ Q + +
Sbjct: 122 ---------------------SDDKTVKVWATHRQKFLFSLS--------QHINWVRCAK 152
Query: 371 ISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDH 430
S +GRL + + V LWD R V Y G + + F A+G D+
Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSRECVHSY--CEHGGFVTYVDFHPSGTCIAAAGM-DN 209
Query: 431 KVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRI 477
V +W R+ + H+ VN +S++P + + +AS D T++I
Sbjct: 210 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS-GNYLITASSDSTLKI 255
Score = 50.1 bits (118), Expect = 5e-06
Identities = 37/136 (27%), Positives = 64/136 (47%), Gaps = 8/136 (5%)
Query: 188 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWS 247
L++H N V KFS DG + + S D TV +W D + + + H V+Y+ +
Sbjct: 141 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLW----DKSSRECVHSYCEHGGFVTYVDFH 196
Query: 248 PDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQF 307
P + A G D+ + +W+V+T L + Q H ++ ++++P G +T
Sbjct: 197 PSGTCIAAAGMDNTVK--VWDVRTHRL-LQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
Query: 308 YQCDL-DGNLLDSWEG 322
DL +G LL + G
Sbjct: 254 KILDLMEGRLLYTLHG 269
Score = 49.7 bits (117), Expect = 6e-06
Identities = 25/62 (40%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
Query: 419 NEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
N +ASGS D + +WH + + TGH V CV+++P ++AS S D TVRIW
Sbjct: 30 NTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS-GHLLASGSRDKTVRIW 88
Query: 479 GP 480
P
Sbjct: 89 VP 90
Score = 43.9 bits (102), Expect = 3e-04
Identities = 64/298 (21%), Positives = 103/298 (34%), Gaps = 71/298 (23%)
Query: 187 ILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAW 246
+ H V F +DG T S D TV +W TH K L +L H V +
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA----THRQKFLFSLSQHINWVRCAKF 153
Query: 247 SPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQ 306
SPD +V+ D +LW ++ H +T V ++P G G
Sbjct: 154 SPDGRLIVSASDDKTVKLW---DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGM--- 207
Query: 307 FYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPI 366
N + W+ VR TH+ ++ Y +
Sbjct: 208 -------DNTVKVWD-VR-----------------THRLLQHYQLHSAAVNGLSFHPSGN 242
Query: 367 MSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFG-------GHN 419
T S + L +L++ ++ R+L YT+H G
Sbjct: 243 YLITASSDSTLKILDL---------MEGRLL-----------YTLHGHQGPATTVAFSRT 282
Query: 420 EDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRI 477
++ ASG D +V +W +S I + T+ P+ P+ +AS+ + TV I
Sbjct: 283 GEYFASGGSDEQVMVW--KSNFDIVDHGEVTKV-------PRPPATLASSMGNLTVSI 331
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 65.1 bits (157), Expect = 1e-10
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 49/287 (17%)
Query: 191 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDD 250
H + V FS + +LA+GS D+ +++W + P + + GH V+ + +SP
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT----GHKDAVTCVNFSPSG 73
Query: 251 NYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQC 310
+ L + D +W+ NV+ GE + + ++H ++ SV + DG+ FVT
Sbjct: 74 HLLASGSRDKTVRIWVPNVK-GE--STVFRAHTATVRSVHFCSDGQSFVTA--------- 121
Query: 311 DLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFT 370
SD KTV TH++ ++ Q + +
Sbjct: 122 ---------------------SDDKTVKVWATHRQKFLFSLS--------QHINWVRCAK 152
Query: 371 ISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDH 430
S +GRL + + V LWD R V Y G + + F A+G D+
Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSRECVHSY--CEHGGFVTYVDFHPSGTCIAAAGM-DN 209
Query: 431 KVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRI 477
V +W R+ + H+ VN +S++P + + +AS D T++I
Sbjct: 210 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS-GNYLITASSDSTLKI 255
Score = 50.1 bits (118), Expect = 5e-06
Identities = 37/136 (27%), Positives = 64/136 (47%), Gaps = 8/136 (5%)
Query: 188 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWS 247
L++H N V KFS DG + + S D TV +W D + + + H V+Y+ +
Sbjct: 141 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLW----DKSSRECVHSYCEHGGFVTYVDFH 196
Query: 248 PDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQF 307
P + A G D+ + +W+V+T L + Q H ++ ++++P G +T
Sbjct: 197 PSGTCIAAAGMDNTVK--VWDVRTHRL-LQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
Query: 308 YQCDL-DGNLLDSWEG 322
DL +G LL + G
Sbjct: 254 KILDLMEGRLLYTLHG 269
Score = 49.7 bits (117), Expect = 6e-06
Identities = 25/62 (40%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
Query: 419 NEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
N +ASGS D + +WH + + TGH V CV+++P ++AS S D TVRIW
Sbjct: 30 NTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS-GHLLASGSRDKTVRIW 88
Query: 479 GP 480
P
Sbjct: 89 VP 90
Score = 41.6 bits (96), Expect = 0.002
Identities = 25/79 (31%), Positives = 33/79 (41%), Gaps = 4/79 (5%)
Query: 187 ILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAW 246
+ H V F +DG T S D TV +W TH K L +L H V +
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA----THRQKFLFSLSQHINWVRCAKF 153
Query: 247 SPDDNYLVACGPDDCSELW 265
SPD +V+ D +LW
Sbjct: 154 SPDGRLIVSASDDKTVKLW 172
Score = 34.3 bits (77), Expect = 0.27
Identities = 57/286 (19%), Positives = 100/286 (34%), Gaps = 72/286 (25%)
Query: 189 TEHCNEVWFCKFSNDGTKLATGSKDTTVIIW--QVDPDTHLLKLLKTLEGHAYGVSYIAW 246
T H + V FS G LA+GS+D TV IW V ++ + + H V + +
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR------AHTATVRSVHF 111
Query: 247 SPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQ 306
D V D ++W + Q + +SQ H + + ++PDG+ V+
Sbjct: 112 CSDGQSFVTASDDKTVKVWATHRQ--KFLFSLSQ-HINWVRCAKFSPDGRLIVSAS---- 164
Query: 307 FYQCDLDGNLLDSWEGVRVQCL--WCLSDG--------------------KTVLASD--T 342
D + W+ +C+ +C G TV D T
Sbjct: 165 ------DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 218
Query: 343 HQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQ 402
H+ ++ Y + T S + L +L++ ++ R+L
Sbjct: 219 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL---------MEGRLL----- 264
Query: 403 GVTQGFYTIHSCFG-------GHNEDFIASGSEDHKVYIWHKRSEL 441
YT+H G ++ ASG D +V +W ++
Sbjct: 265 ------YTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDI 304
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 64.3 bits (155), Expect = 2e-10
Identities = 63/249 (25%), Positives = 99/249 (39%), Gaps = 46/249 (18%)
Query: 231 LKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVA 290
L+ + HA VS + L+A G DDC + LW++ ++ H + SV
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDC-RVNLWSINKPNCIMSLT-GHTSPVESVR 70
Query: 291 WNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYN 350
N + V G Q G +RV W L K + H+
Sbjct: 71 LNTPEELIVAGSQSGS----------------IRV---WDLEAAKILRTLMGHKA----- 106
Query: 351 FEDLTDRNIVQED-HPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFY 409
NI D HP F S + + LWD++ + V +Y+G +Q
Sbjct: 107 -------NICSLDFHPYGEFVASGS--------QDTNIKLWDIRRKGCVFRYRGHSQAVR 151
Query: 410 TIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASA 469
+ G ++AS ++DH V +W + ++E GHT VN V ++P ++AS
Sbjct: 152 CLRFSPDGK---WLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPN-EYLLASG 207
Query: 470 SDDGTVRIW 478
S D T+R W
Sbjct: 208 SSDRTIRFW 216
Score = 49.3 bits (116), Expect = 8e-06
Identities = 60/283 (21%), Positives = 106/283 (37%), Gaps = 50/283 (17%)
Query: 204 GTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSE 263
G LATG D V +W ++ ++ +L GH V + + + +VA
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIM----SLTGHTSPVESVRLNTPEELIVA--GSQSGS 86
Query: 264 LWLWNVQTGE-LRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEG 322
+ +W+++ + LRT M H+ ++ S+ ++P G+ +G Q D N+ W+
Sbjct: 87 IRVWDLEAAKILRTLMG--HKANICSLDFHPYGEFVASGSQ---------DTNI-KLWDI 134
Query: 323 VRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNV 382
R C++ R RG++ + S +G+
Sbjct: 135 RRKGCVF---------------RYRGHS-------------QAVRCLRFSPDGKWLASAA 166
Query: 383 ATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELP 442
V LWDL ++ ++ G T + NE +ASGS D + W
Sbjct: 167 DDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF---HPNEYLLASGSSDRTIRFWDLEKFQV 223
Query: 443 IAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPAPFID 485
++ + G V V +NP + + D V W P D
Sbjct: 224 VSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFD 266
Score = 43.5 bits (101), Expect = 4e-04
Identities = 32/113 (28%), Positives = 54/113 (47%), Gaps = 7/113 (6%)
Query: 191 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDD 250
H V +FS DG LA+ + D TV +W D K++ GH V+ + + P++
Sbjct: 146 HSQAVRCLRFSPDGKWLASAADDHTVKLW----DLTAGKMMSEFPGHTGPVNVVEFHPNE 201
Query: 251 NYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQ 303
YL+A G D + W+++ ++ + + SV +NPDG +G Q
Sbjct: 202 -YLLASGSSD-RTIRFWDLEKFQV-VSCIEGEPGPVRSVLFNPDGCCLYSGCQ 251
Score = 38.1 bits (87), Expect = 0.019
Identities = 26/109 (23%), Positives = 52/109 (47%), Gaps = 7/109 (6%)
Query: 188 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWS 247
LT H + V + + + GS+ ++ +W D K+L+TL GH + + +
Sbjct: 59 LTGHTSPVESVRLNTPEELIVAGSQSGSIRVW----DLEAAKILRTLMGHKANICSLDFH 114
Query: 248 PDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGK 296
P + VA G D + + LW+++ + + H ++ + ++PDGK
Sbjct: 115 PYGEF-VASGSQD-TNIKLWDIRRKGCVFRY-RGHSQAVRCLRFSPDGK 160
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 63.9 bits (154), Expect = 3e-10
Identities = 75/290 (25%), Positives = 120/290 (41%), Gaps = 38/290 (13%)
Query: 191 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDD 250
H +EV C FS D +AT S D V IW ++ +L+ T + H+ V+ ++
Sbjct: 656 HEDEVLCCAFSTDDRFIATCSVDKKVKIW----NSMTGELVHTYDEHSEQVNCCHFTNSS 711
Query: 251 NY-LVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQ 309
++ L+A G DC L LW++ E R M H +S+ ++PD K +
Sbjct: 712 HHLLLATGSSDCF-LKLWDLNQKECRNTMF-GHTNSVNHCRFSPDDKLLAS--------- 760
Query: 310 CDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSF 369
C DG L LW + + + Q N ED QED ++
Sbjct: 761 CSADGTLK----------LWDATSANERKSINVKQFF--LNLED------PQEDMEVIVK 802
Query: 370 TISKNGRLALLNVATQG-VHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSE 428
S + A + VA + + L+D+ L+ + T TI C
Sbjct: 803 CCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIH--TGHHSTIQYCDFSPQNHLAVVALS 860
Query: 429 DHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
+ V +W+ S +A+ GH V+ V ++P S + S SDD T+R+W
Sbjct: 861 QYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS-SDDQTIRLW 909
Score = 63.5 bits (153), Expect = 4e-10
Identities = 69/294 (23%), Positives = 124/294 (42%), Gaps = 26/294 (8%)
Query: 191 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDD 250
H + V FS DG+ T S D T+ +W+ + K + V + +
Sbjct: 881 HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK---VCKNSAVMLKQEVDVVF-----QE 932
Query: 251 NYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQC 310
N ++ D L L N +TG++ E ++ +P + G + G
Sbjct: 933 NEVMVLAVDHIRRLQLINGRTGQI----DYLTEAQVSCCCLSPHLQYIAFGDENGAIEIL 988
Query: 311 DLDGNLLDSWEGVRVQCLWCL---SDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHP-- 365
+L N + + +W + +D KT+++S I+ +N++ D+ I H
Sbjct: 989 ELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQ--LDKCIFLRGHQET 1046
Query: 366 IMSFTISKNGRLALLNVATQG-VHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIA 424
+ F + KN RL L+ + G V +W++ + K + T+ SC H+ +
Sbjct: 1047 VKDFRLLKNSRL--LSWSFDGTVKVWNI---ITGNKEKDFVCHQGTVLSCDISHDATKFS 1101
Query: 425 SGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
S S D IW LP+ EL GH V C +++ +++A+ D+G +RIW
Sbjct: 1102 STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD-STLLATGDDNGEIRIW 1154
Score = 53.5 bits (127), Expect = 4e-07
Identities = 88/402 (21%), Positives = 144/402 (35%), Gaps = 105/402 (26%)
Query: 190 EHCNEVWFCKFSNDGTKL--ATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWS 247
EH +V C F+N L ATGS D + +W D + + T+ GH V++ +S
Sbjct: 697 EHSEQVNCCHFTNSSHHLLLATGSSDCFLKLW----DLNQKECRNTMFGHTNSVNHCRFS 752
Query: 248 PDDNYLVACGPDDCSELW-------LWNVQTGELRTKMSQSHEDSLTSV---AWNPDGKR 297
PDD L +C D +LW ++ + + ED V +W+ DG R
Sbjct: 753 PDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGAR 812
Query: 298 FV-------------TGGQRGQFY--------QCD-----------LDGNLLDSW----E 321
+ T G G+ + CD L ++ W
Sbjct: 813 IMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSR 872
Query: 322 GVRVQCLWCLS---------DGKTVLASDTHQRIRGYNFEDL---------TDRNIVQED 363
C LS DG + L S Q IR + + + + ++V ++
Sbjct: 873 SKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQE 932
Query: 364 HPIMSFTISKNGRLALLNVATQGV---------------HLW-----------DLQDRVL 397
+ +M + RL L+N T + HL ++ + V
Sbjct: 933 NEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVN 992
Query: 398 VRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVS 457
R +Q Q T+ +E + S S+D ++ +W+ + + I L GH TV
Sbjct: 993 NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVK--D 1049
Query: 458 WNPQIPSMMASASDDGTVRIWG------PAPFIDHQNIEEEC 493
+ S + S S DGTV++W F+ HQ C
Sbjct: 1050 FRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1091
Score = 44.3 bits (103), Expect = 3e-04
Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 11/114 (9%)
Query: 200 FSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTL--EG---HAYGVSYIAWSPDDNYLV 254
FS D T LATG + + IW V + LL L L EG H V+ + +SPD L+
Sbjct: 1135 FSVDSTLLATGDDNGEIRIWNVS-NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1193
Query: 255 ACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFY 308
+ G + WNV TGE ++ ++ +L + +PD K +VT G Y
Sbjct: 1194 SAG----GYIKWWNVVTGE-SSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILY 1242
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 63.9 bits (154), Expect = 3e-10
Identities = 75/290 (25%), Positives = 120/290 (41%), Gaps = 38/290 (13%)
Query: 191 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDD 250
H +EV C FS D +AT S D V IW ++ +L+ T + H+ V+ ++
Sbjct: 645 HEDEVLCCAFSTDDRFIATCSVDKKVKIW----NSMTGELVHTYDEHSEQVNCCHFTNSS 700
Query: 251 NY-LVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQ 309
++ L+A G DC L LW++ E R M H +S+ ++PD K +
Sbjct: 701 HHLLLATGSSDCF-LKLWDLNQKECRNTMF-GHTNSVNHCRFSPDDKLLAS--------- 749
Query: 310 CDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSF 369
C DG L LW + + + Q N ED QED ++
Sbjct: 750 CSADGTLK----------LWDATSANERKSINVKQFF--LNLED------PQEDMEVIVK 791
Query: 370 TISKNGRLALLNVATQG-VHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSE 428
S + A + VA + + L+D+ L+ + T TI C
Sbjct: 792 CCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIH--TGHHSTIQYCDFSPQNHLAVVALS 849
Query: 429 DHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
+ V +W+ S +A+ GH V+ V ++P S + S SDD T+R+W
Sbjct: 850 QYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS-SDDQTIRLW 898
Score = 63.5 bits (153), Expect = 4e-10
Identities = 69/294 (23%), Positives = 124/294 (42%), Gaps = 26/294 (8%)
Query: 191 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDD 250
H + V FS DG+ T S D T+ +W+ + K + V + +
Sbjct: 870 HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK---VCKNSAVMLKQEVDVVF-----QE 921
Query: 251 NYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQC 310
N ++ D L L N +TG++ E ++ +P + G + G
Sbjct: 922 NEVMVLAVDHIRRLQLINGRTGQI----DYLTEAQVSCCCLSPHLQYIAFGDENGAIEIL 977
Query: 311 DLDGNLLDSWEGVRVQCLWCL---SDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHP-- 365
+L N + + +W + +D KT+++S I+ +N++ D+ I H
Sbjct: 978 ELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQ--LDKCIFLRGHQET 1035
Query: 366 IMSFTISKNGRLALLNVATQG-VHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIA 424
+ F + KN RL L+ + G V +W++ + K + T+ SC H+ +
Sbjct: 1036 VKDFRLLKNSRL--LSWSFDGTVKVWNI---ITGNKEKDFVCHQGTVLSCDISHDATKFS 1090
Query: 425 SGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
S S D IW LP+ EL GH V C +++ +++A+ D+G +RIW
Sbjct: 1091 STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD-STLLATGDDNGEIRIW 1143
Score = 53.5 bits (127), Expect = 4e-07
Identities = 88/402 (21%), Positives = 144/402 (35%), Gaps = 105/402 (26%)
Query: 190 EHCNEVWFCKFSNDGTKL--ATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWS 247
EH +V C F+N L ATGS D + +W D + + T+ GH V++ +S
Sbjct: 686 EHSEQVNCCHFTNSSHHLLLATGSSDCFLKLW----DLNQKECRNTMFGHTNSVNHCRFS 741
Query: 248 PDDNYLVACGPDDCSELW-------LWNVQTGELRTKMSQSHEDSLTSV---AWNPDGKR 297
PDD L +C D +LW ++ + + ED V +W+ DG R
Sbjct: 742 PDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGAR 801
Query: 298 FV-------------TGGQRGQFY--------QCD-----------LDGNLLDSW----E 321
+ T G G+ + CD L ++ W
Sbjct: 802 IMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSR 861
Query: 322 GVRVQCLWCLS---------DGKTVLASDTHQRIRGYNFEDL---------TDRNIVQED 363
C LS DG + L S Q IR + + + + ++V ++
Sbjct: 862 SKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQE 921
Query: 364 HPIMSFTISKNGRLALLNVATQGV---------------HLW-----------DLQDRVL 397
+ +M + RL L+N T + HL ++ + V
Sbjct: 922 NEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVN 981
Query: 398 VRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVS 457
R +Q Q T+ +E + S S+D ++ +W+ + + I L GH TV
Sbjct: 982 NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVK--D 1038
Query: 458 WNPQIPSMMASASDDGTVRIWG------PAPFIDHQNIEEEC 493
+ S + S S DGTV++W F+ HQ C
Sbjct: 1039 FRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1080
Score = 44.3 bits (103), Expect = 3e-04
Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 11/114 (9%)
Query: 200 FSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTL--EG---HAYGVSYIAWSPDDNYLV 254
FS D T LATG + + IW V + LL L L EG H V+ + +SPD L+
Sbjct: 1124 FSVDSTLLATGDDNGEIRIWNVS-NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1182
Query: 255 ACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFY 308
+ G + WNV TGE ++ ++ +L + +PD K +VT G Y
Sbjct: 1183 SAG----GYIKWWNVVTGE-SSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILY 1231
>gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens]
Length = 619
Score = 63.5 bits (153), Expect = 4e-10
Identities = 72/319 (22%), Positives = 127/319 (39%), Gaps = 32/319 (10%)
Query: 174 VCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKT 233
VC + P Q +L H +EV +F + + LATG D + +W V L+ +T
Sbjct: 318 VCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSR--LEANQT 375
Query: 234 LEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQS-HEDSLTSVAWN 292
LEG ++ + + P ++A + ++LW + GE ++K + S H+D +T+ +
Sbjct: 376 LEGAGGSITSVDFDPSGYQVLAATYNQAAQLW----KVGEAQSKETLSGHKDKVTAAKFK 431
Query: 293 PDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFE 352
+ VTG + + DL V C + +++ Q+IR ++
Sbjct: 432 LTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSR 491
Query: 353 DLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLW----DLQDRVLVRKYQGVTQGF 408
P + I GR+ L+++ +HL D +V+ + + Q F
Sbjct: 492 G-----------PHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVF 540
Query: 409 YTIHSCFGGH--------NEDFIASGSEDHKVYIWHKRSELPIAELTG-HTRTVNCVSWN 459
G + + +GS D +YIW + + L G H VN V+W
Sbjct: 541 RADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAW- 599
Query: 460 PQIPSMMASASDDGTVRIW 478
S M S V +W
Sbjct: 600 CYSGSHMVSVDQGRKVVLW 618
>gi|148727341 serine/threonine kinase receptor associated protein
[Homo sapiens]
Length = 350
Score = 63.2 bits (152), Expect = 5e-10
Identities = 57/288 (19%), Positives = 109/288 (37%), Gaps = 53/288 (18%)
Query: 191 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDD 250
H VW + D TK AT + D T +W L+ L H + V + ++ D
Sbjct: 58 HKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTL-----AHKHIVKTVDFTQDS 112
Query: 251 NYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQC 310
NYL+ G D L ++++ E K H + W
Sbjct: 113 NYLLTGGQDKL--LRIYDLNKPEAEPKEISGHTSGIKKALW------------------- 151
Query: 311 DLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFT 370
S+ K +L++D + +R ++ +T+ + + + S
Sbjct: 152 --------------------CSEDKQILSAD-DKTVRLWDHATMTEVKSLNFNMSVSSME 190
Query: 371 ISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDH 430
G + ++ + + ++ ++ TI+S ++F+ +G ED
Sbjct: 191 YIPEGEILVITYG-RSIAFHSAVSLDPIKSFEAPA----TINSASLHPEKEFLVAGGEDF 245
Query: 431 KVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
K+Y + S + GH ++CV ++P + AS S+DGT+R+W
Sbjct: 246 KLYKYDYNSGEELESYKGHFGPIHCVRFSPD-GELYASGSEDGTLRLW 292
Score = 31.6 bits (70), Expect = 1.7
Identities = 20/82 (24%), Positives = 40/82 (48%), Gaps = 5/82 (6%)
Query: 419 NEDFIASGSEDHKVYIWH-KRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRI 477
+ +++ +G +D + I+ + E E++GHT + W + ++++ DD TVR+
Sbjct: 111 DSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA--DDKTVRL 168
Query: 478 WGPAPF--IDHQNIEEECSSMD 497
W A + N SSM+
Sbjct: 169 WDHATMTEVKSLNFNMSVSSME 190
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 62.4 bits (150), Expect = 9e-10
Identities = 69/276 (25%), Positives = 103/276 (37%), Gaps = 44/276 (15%)
Query: 234 LEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSH----------- 282
L GH V AW+P + L + D + +W N + T++ H
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 283 EDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNL---LDSWEGVRVQCLW------CLSD 333
+TS+ WN +G TG G DGNL L +G W LS
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSA 296
Query: 334 G--KTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQG-VHLW 390
G KT + D H F H + + + +T +H+
Sbjct: 297 GVDKTTIIWDAHTGEAKQQFPF----------HSAPALDVDWQNNTTFASCSTDMCIHVC 346
Query: 391 DLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHT 450
L V+ +QG T I G +AS S+D + IW + E+ I +L H
Sbjct: 347 RLGCDRPVKTFQGHTNEVNAIKWDPSGM---LLASCSDDMTLKIWSMKQEVCIHDLQAHN 403
Query: 451 RTVNCVSWNPQIPS--------MMASASDDGTVRIW 478
+ + + W+P P+ M+ASAS D TVR+W
Sbjct: 404 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439
Score = 53.9 bits (128), Expect = 3e-07
Identities = 71/311 (22%), Positives = 122/311 (39%), Gaps = 39/311 (12%)
Query: 186 QILTEHC-----------NEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTL 234
Q++ HC +V ++ +GT LATGS D IW D + L TL
Sbjct: 220 QLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGN-----LASTL 274
Query: 235 EGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPD 294
H + + W+ NY+++ G D + +W+ TGE + + H V W +
Sbjct: 275 GQHKGPIFALKWNRKGNYILSAGVDKTT--IIWDAHTGEAKQQF-PFHSAPALDVDWQ-N 330
Query: 295 GKRFVTGGQRGQFYQCDL---------DGNLLD----SWEGVRVQCLWCLSDGKTVLASD 341
F + + C L G+ + W+ + C SD T+
Sbjct: 331 NTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASC-SDDMTLKIWS 389
Query: 342 THQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQG-VHLWDLQDRVLVRK 400
Q + ++ + + P T + N + L + + V LWD++ V
Sbjct: 390 MKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHT 449
Query: 401 YQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNP 460
+T+ ++S + ++ASGS D V+IW+ +S + G T + V WN
Sbjct: 450 ---LTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNA 505
Query: 461 QIPSMMASASD 471
+ + ASASD
Sbjct: 506 RGDKVGASASD 516
Score = 47.8 bits (112), Expect = 2e-05
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 21/136 (15%)
Query: 188 LTEHCNEVWFCKFS---------NDGTKLATGSKDTTVIIWQVDPD--THLLKLLKTLEG 236
L H E++ K+S N LA+ S D+TV +W ++ TH TL
Sbjct: 399 LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTH------TLTK 452
Query: 237 HAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGK 296
H V +A+SPD YL + D C + +WN Q+G L S + V WN G
Sbjct: 453 HQEPVYSVAFSPDGKYLASGSFDKC--VHIWNTQSGNL--VHSYRGTGGIFEVCWNARGD 508
Query: 297 RFVTGGQRGQFYQCDL 312
+ G DL
Sbjct: 509 KVGASASDGSVCVLDL 524
Score = 33.5 bits (75), Expect = 0.46
Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 4/42 (9%)
Query: 440 ELPIAELT---GHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
E+P ++ T GH V +WNP + ++AS S D T RIW
Sbjct: 168 EIPSSKATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIW 208
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 62.4 bits (150), Expect = 9e-10
Identities = 69/276 (25%), Positives = 103/276 (37%), Gaps = 44/276 (15%)
Query: 234 LEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSH----------- 282
L GH V AW+P + L + D + +W N + T++ H
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 283 EDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNL---LDSWEGVRVQCLW------CLSD 333
+TS+ WN +G TG G DGNL L +G W LS
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSA 296
Query: 334 G--KTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQG-VHLW 390
G KT + D H F H + + + +T +H+
Sbjct: 297 GVDKTTIIWDAHTGEAKQQFPF----------HSAPALDVDWQNNTTFASCSTDMCIHVC 346
Query: 391 DLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHT 450
L V+ +QG T I G +AS S+D + IW + E+ I +L H
Sbjct: 347 RLGCDRPVKTFQGHTNEVNAIKWDPSGM---LLASCSDDMTLKIWSMKQEVCIHDLQAHN 403
Query: 451 RTVNCVSWNPQIPS--------MMASASDDGTVRIW 478
+ + + W+P P+ M+ASAS D TVR+W
Sbjct: 404 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439
Score = 53.9 bits (128), Expect = 3e-07
Identities = 71/311 (22%), Positives = 122/311 (39%), Gaps = 39/311 (12%)
Query: 186 QILTEHC-----------NEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTL 234
Q++ HC +V ++ +GT LATGS D IW D + L TL
Sbjct: 220 QLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGN-----LASTL 274
Query: 235 EGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPD 294
H + + W+ NY+++ G D + +W+ TGE + + H V W +
Sbjct: 275 GQHKGPIFALKWNRKGNYILSAGVDKTT--IIWDAHTGEAKQQF-PFHSAPALDVDWQ-N 330
Query: 295 GKRFVTGGQRGQFYQCDL---------DGNLLD----SWEGVRVQCLWCLSDGKTVLASD 341
F + + C L G+ + W+ + C SD T+
Sbjct: 331 NTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASC-SDDMTLKIWS 389
Query: 342 THQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQG-VHLWDLQDRVLVRK 400
Q + ++ + + P T + N + L + + V LWD++ V
Sbjct: 390 MKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHT 449
Query: 401 YQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNP 460
+T+ ++S + ++ASGS D V+IW+ +S + G T + V WN
Sbjct: 450 ---LTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNA 505
Query: 461 QIPSMMASASD 471
+ + ASASD
Sbjct: 506 RGDKVGASASD 516
Score = 47.8 bits (112), Expect = 2e-05
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 21/136 (15%)
Query: 188 LTEHCNEVWFCKFS---------NDGTKLATGSKDTTVIIWQVDPD--THLLKLLKTLEG 236
L H E++ K+S N LA+ S D+TV +W ++ TH TL
Sbjct: 399 LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTH------TLTK 452
Query: 237 HAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGK 296
H V +A+SPD YL + D C + +WN Q+G L S + V WN G
Sbjct: 453 HQEPVYSVAFSPDGKYLASGSFDKC--VHIWNTQSGNL--VHSYRGTGGIFEVCWNARGD 508
Query: 297 RFVTGGQRGQFYQCDL 312
+ G DL
Sbjct: 509 KVGASASDGSVCVLDL 524
Score = 33.5 bits (75), Expect = 0.46
Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 4/42 (9%)
Query: 440 ELPIAELT---GHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
E+P ++ T GH V +WNP + ++AS S D T RIW
Sbjct: 168 EIPSSKATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIW 208
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 62.4 bits (150), Expect = 9e-10
Identities = 69/276 (25%), Positives = 103/276 (37%), Gaps = 44/276 (15%)
Query: 234 LEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSH----------- 282
L GH V AW+P + L + D + +W N + T++ H
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
Query: 283 EDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNL---LDSWEGVRVQCLW------CLSD 333
+TS+ WN +G TG G DGNL L +G W LS
Sbjct: 288 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSA 347
Query: 334 G--KTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQG-VHLW 390
G KT + D H F H + + + +T +H+
Sbjct: 348 GVDKTTIIWDAHTGEAKQQFPF----------HSAPALDVDWQNNTTFASCSTDMCIHVC 397
Query: 391 DLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHT 450
L V+ +QG T I G +AS S+D + IW + E+ I +L H
Sbjct: 398 RLGCDRPVKTFQGHTNEVNAIKWDPSGM---LLASCSDDMTLKIWSMKQEVCIHDLQAHN 454
Query: 451 RTVNCVSWNPQIPS--------MMASASDDGTVRIW 478
+ + + W+P P+ M+ASAS D TVR+W
Sbjct: 455 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490
Score = 53.9 bits (128), Expect = 3e-07
Identities = 71/311 (22%), Positives = 122/311 (39%), Gaps = 39/311 (12%)
Query: 186 QILTEHC-----------NEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTL 234
Q++ HC +V ++ +GT LATGS D IW D + L TL
Sbjct: 271 QLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGN-----LASTL 325
Query: 235 EGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPD 294
H + + W+ NY+++ G D + +W+ TGE + + H V W +
Sbjct: 326 GQHKGPIFALKWNRKGNYILSAGVDKTT--IIWDAHTGEAKQQF-PFHSAPALDVDWQ-N 381
Query: 295 GKRFVTGGQRGQFYQCDL---------DGNLLD----SWEGVRVQCLWCLSDGKTVLASD 341
F + + C L G+ + W+ + C SD T+
Sbjct: 382 NTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASC-SDDMTLKIWS 440
Query: 342 THQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQG-VHLWDLQDRVLVRK 400
Q + ++ + + P T + N + L + + V LWD++ V
Sbjct: 441 MKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHT 500
Query: 401 YQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNP 460
+T+ ++S + ++ASGS D V+IW+ +S + G T + V WN
Sbjct: 501 ---LTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNA 556
Query: 461 QIPSMMASASD 471
+ + ASASD
Sbjct: 557 RGDKVGASASD 567
Score = 47.8 bits (112), Expect = 2e-05
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 21/136 (15%)
Query: 188 LTEHCNEVWFCKFS---------NDGTKLATGSKDTTVIIWQVDPD--THLLKLLKTLEG 236
L H E++ K+S N LA+ S D+TV +W ++ TH TL
Sbjct: 450 LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTH------TLTK 503
Query: 237 HAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGK 296
H V +A+SPD YL + D C + +WN Q+G L S + V WN G
Sbjct: 504 HQEPVYSVAFSPDGKYLASGSFDKC--VHIWNTQSGNL--VHSYRGTGGIFEVCWNARGD 559
Query: 297 RFVTGGQRGQFYQCDL 312
+ G DL
Sbjct: 560 KVGASASDGSVCVLDL 575
Score = 33.5 bits (75), Expect = 0.46
Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 4/42 (9%)
Query: 440 ELPIAELT---GHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
E+P ++ T GH V +WNP + ++AS S D T RIW
Sbjct: 219 EIPSSKATVLRGHESEVFICAWNP-VSDLLASGSGDSTARIW 259
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,434,955
Number of Sequences: 37866
Number of extensions: 912604
Number of successful extensions: 4262
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 196
Number of HSP's successfully gapped in prelim test: 122
Number of HSP's that attempted gapping in prelim test: 1977
Number of HSP's gapped (non-prelim): 1554
length of query: 498
length of database: 18,247,518
effective HSP length: 106
effective length of query: 392
effective length of database: 14,233,722
effective search space: 5579619024
effective search space used: 5579619024
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.