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Search of human proteins with 169234742
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169234742 NACHT and WD repeat domain containing 1 [Homo
sapiens]
(1429 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169234742 NACHT and WD repeat domain containing 1 [Homo sapiens] 2873 0.0
gi|222418587 hypothetical protein LOC57495 [Homo sapiens] 221 4e-57
gi|32189425 WD repeat domain 69 [Homo sapiens] 69 2e-11
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 67 1e-10
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 64 8e-10
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 63 2e-09
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 63 2e-09
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 63 2e-09
gi|16554629 WD repeat domain 5 [Homo sapiens] 60 1e-08
gi|16554627 WD repeat domain 5 [Homo sapiens] 60 1e-08
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 60 2e-08
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 60 2e-08
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 59 4e-08
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 59 4e-08
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 58 6e-08
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 57 2e-07
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 57 2e-07
gi|23199987 WD repeat domain 5B [Homo sapiens] 55 4e-07
gi|55769546 PAK1 interacting protein 1 [Homo sapiens] 55 5e-07
gi|19913369 transducin beta-like 3 [Homo sapiens] 55 5e-07
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 54 1e-06
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 53 2e-06
gi|113865883 WD repeat domain 38 [Homo sapiens] 53 2e-06
gi|157266266 WD repeat domain 86 [Homo sapiens] 53 2e-06
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 52 4e-06
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 52 4e-06
gi|18874090 WD repeat domain 48 [Homo sapiens] 52 5e-06
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 52 5e-06
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 52 5e-06
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 52 5e-06
>gi|169234742 NACHT and WD repeat domain containing 1 [Homo sapiens]
Length = 1429
Score = 2873 bits (7449), Expect = 0.0
Identities = 1429/1429 (100%), Positives = 1429/1429 (100%)
Query: 1 MDSQFHMAGEASQSWLKAKEKQRGTSYMVAVIEWEIERSLLSSEDREQGATVFLREIQDL 60
MDSQFHMAGEASQSWLKAKEKQRGTSYMVAVIEWEIERSLLSSEDREQGATVFLREIQDL
Sbjct: 1 MDSQFHMAGEASQSWLKAKEKQRGTSYMVAVIEWEIERSLLSSEDREQGATVFLREIQDL 60
Query: 61 HKHILEDCALRMVDRLADGCLDADAQNLLSSLKSHITDMHPGVLKTHRLPWSRDLVNPKN 120
HKHILEDCALRMVDRLADGCLDADAQNLLSSLKSHITDMHPGVLKTHRLPWSRDLVNPKN
Sbjct: 61 HKHILEDCALRMVDRLADGCLDADAQNLLSSLKSHITDMHPGVLKTHRLPWSRDLVNPKN 120
Query: 121 KTHACYLKELGEQFVVRANHQVLTRLRELDTAGQELAWLYQEIRHHLWQSSEVIQTFCGR 180
KTHACYLKELGEQFVVRANHQVLTRLRELDTAGQELAWLYQEIRHHLWQSSEVIQTFCGR
Sbjct: 121 KTHACYLKELGEQFVVRANHQVLTRLRELDTAGQELAWLYQEIRHHLWQSSEVIQTFCGR 180
Query: 181 QELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLGHKTVTVLRLLGT 240
QELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLGHKTVTVLRLLGT
Sbjct: 181 QELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLGHKTVTVLRLLGT 240
Query: 241 SQMSSDARGLLKSICFQVCLAYGLPLPPAQVLDAHTRVVQFFHTLLHTVSCRNFESLVLL 300
SQMSSDARGLLKSICFQVCLAYGLPLPPAQVLDAHTRVVQFFHTLLHTVSCRNFESLVLL
Sbjct: 241 SQMSSDARGLLKSICFQVCLAYGLPLPPAQVLDAHTRVVQFFHTLLHTVSCRNFESLVLL 300
Query: 301 LDAMDDLDSVRHARRVPWLPLNCPPRVHLILSACSGALGVLDTLQRVLLDPEAYWEVKPL 360
LDAMDDLDSVRHARRVPWLPLNCPPRVHLILSACSGALGVLDTLQRVLLDPEAYWEVKPL
Sbjct: 301 LDAMDDLDSVRHARRVPWLPLNCPPRVHLILSACSGALGVLDTLQRVLLDPEAYWEVKPL 360
Query: 361 SGNQGQQMIQLLLAAARRTLSPVHTDLLWASLPECGNPGRLRLAFEEARKWASFTVPVPL 420
SGNQGQQMIQLLLAAARRTLSPVHTDLLWASLPECGNPGRLRLAFEEARKWASFTVPVPL
Sbjct: 361 SGNQGQQMIQLLLAAARRTLSPVHTDLLWASLPECGNPGRLRLAFEEARKWASFTVPVPL 420
Query: 421 ATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQDVYRD 480
ATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQDVYRD
Sbjct: 421 ATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQDVYRD 480
Query: 481 WTPPSKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSGSERA 540
WTPPSKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSGSERA
Sbjct: 481 WTPPSKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSGSERA 540
Query: 541 KRHGVLADFFSGTWSQGTKKLITLPLVGKPLNLDRKVAPQPLWFSHTVANLRKLKELPYH 600
KRHGVLADFFSGTWSQGTKKLITLPLVGKPLNLDRKVAPQPLWFSHTVANLRKLKELPYH
Sbjct: 541 KRHGVLADFFSGTWSQGTKKLITLPLVGKPLNLDRKVAPQPLWFSHTVANLRKLKELPYH 600
Query: 601 LLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCR 660
LLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCR
Sbjct: 601 LLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCR 660
Query: 661 PAVELRGMERSLLYTELLARLHFFATSHPALVGQLCQQAQSWFQLCAHPVLVPLGGFLQP 720
PAVELRGMERSLLYTELLARLHFFATSHPALVGQLCQQAQSWFQLCAHPVLVPLGGFLQP
Sbjct: 661 PAVELRGMERSLLYTELLARLHFFATSHPALVGQLCQQAQSWFQLCAHPVLVPLGGFLQP 720
Query: 721 PGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRC 780
PGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRC
Sbjct: 721 PGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRC 780
Query: 781 VKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYS 840
VKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYS
Sbjct: 781 VKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYS 840
Query: 841 ASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQ 900
ASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQ
Sbjct: 841 ASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQ 900
Query: 901 GKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSED 960
GKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSED
Sbjct: 901 GKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSED 960
Query: 961 ESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVW 1020
ESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVW
Sbjct: 961 ESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVW 1020
Query: 1021 SLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKVWDLSDAHRSRVPAPFLDRT 1080
SLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKVWDLSDAHRSRVPAPFLDRT
Sbjct: 1021 SLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKVWDLSDAHRSRVPAPFLDRT 1080
Query: 1081 GLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDTSSEIRCLEVAEQRKLLFTGLV 1140
GLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDTSSEIRCLEVAEQRKLLFTGLV
Sbjct: 1081 GLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDTSSEIRCLEVAEQRKLLFTGLV 1140
Query: 1141 SGVVLVFPLNSRQDVICIPPPEARKAINCMSLSKCEDRLAIAYDNIVLVLDITSGDPCPV 1200
SGVVLVFPLNSRQDVICIPPPEARKAINCMSLSKCEDRLAIAYDNIVLVLDITSGDPCPV
Sbjct: 1141 SGVVLVFPLNSRQDVICIPPPEARKAINCMSLSKCEDRLAIAYDNIVLVLDITSGDPCPV 1200
Query: 1201 IDGPRYTFYTQLPETLSSVAILTDYRVVYSMTNGDLFLYECATSKAFPLETHRSRVACVE 1260
IDGPRYTFYTQLPETLSSVAILTDYRVVYSMTNGDLFLYECATSKAFPLETHRSRVACVE
Sbjct: 1201 IDGPRYTFYTQLPETLSSVAILTDYRVVYSMTNGDLFLYECATSKAFPLETHRSRVACVE 1260
Query: 1261 VSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDR 1320
VSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDR
Sbjct: 1261 VSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDR 1320
Query: 1321 SILVWSVLDGTLLTVQFVHAVVNRIIPTTSGFIAPTRHGYLIRENFQCLSAKASPQDPLK 1380
SILVWSVLDGTLLTVQFVHAVVNRIIPTTSGFIAPTRHGYLIRENFQCLSAKASPQDPLK
Sbjct: 1321 SILVWSVLDGTLLTVQFVHAVVNRIIPTTSGFIAPTRHGYLIRENFQCLSAKASPQDPLK 1380
Query: 1381 NFKKAMWMVKSRQREELVAAAGAPQDLESESAQGNETKSNKCSQVCLIV 1429
NFKKAMWMVKSRQREELVAAAGAPQDLESESAQGNETKSNKCSQVCLIV
Sbjct: 1381 NFKKAMWMVKSRQREELVAAAGAPQDLESESAQGNETKSNKCSQVCLIV 1429
>gi|222418587 hypothetical protein LOC57495 [Homo sapiens]
Length = 1742
Score = 221 bits (563), Expect = 4e-57
Identities = 261/1088 (23%), Positives = 461/1088 (42%), Gaps = 136/1088 (12%)
Query: 126 YLKELGEQF------VVRANHQVLTRLRELDTAGQELAWLYQEIRHHLWQSSEVIQTFCG 179
Y++ LG+QF +++A Q + DT E LY EI H +
Sbjct: 338 YIEGLGKQFYEDMIDIIQATIQ-----QNFDT---ETDTLYDEILQHSSLCKTYASFYEY 389
Query: 180 RQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLGHKT------VT 233
+ E L + + + PL+++G P GKT L+ ++A++ L T V
Sbjct: 390 KCESLNIVHNYILPSKAGHINPLIIYGGPCTGKTLLLAEVAKKAYGWLHEDTGPESDPVV 449
Query: 234 VLRLLGTSQMSSDARGLLKSICFQVCLAYGLPLP--PAQVLDAHTRVVQFFHTLLHTVSC 291
++R LGT+ MSSD R LL S+C Q+ + Y + P ++ D + F LL+ S
Sbjct: 450 IVRFLGTTDMSSDLRTLLLSVCEQLAVNYRCLVQSYPKKIHD----LCDLFINLLNESSL 505
Query: 292 RNFESLVLLLDAMDDLDSVRHARRVPWLPLNCPPRVHLILSACSGALGVLDTLQRVLLDP 351
+ LV++ DA++ L AR++ WLP + P V ++LS G+L L+ ++ +
Sbjct: 506 QR--PLVIIFDALEQLSENDDARKLWWLPAHLPRFVRIVLSTLPNKHGILQKLRCLIHEE 563
Query: 352 EAYWEVKPLSGNQGQQMIQLLLAAARRTLSPVHTDLLWASLPECGNPGRLRLAFEEARKW 411
+ Y E+ P Q+++ L +R ++ + +L +C P + L F E R W
Sbjct: 564 DNYIELIPRDRKMCSQVLKHQLLRVKRKVTSGQQIYVNNALSKCTLPMFVNLTFREVRHW 623
Query: 412 ASF--TVPVPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSL 469
S L+ T E+ QL LE+ GQ LV+ LGYI ++ GLSE EL+DVL+L
Sbjct: 624 RSHKDVDESSLSVTVHESIEQLFWSLEKKCGQKLVSRALGYITMAKMGLSEMELEDVLAL 683
Query: 470 DDEVLQDVYRDWTPPSKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVV 529
D+ V+ ++ + P + LR P L RL+ L YL R V TLL A+R L +
Sbjct: 684 DNSVMSELKENTRPSNP--LRVPYLYIARLKEGLSGYLIERHVKNVTLLVWANRHLQLIA 741
Query: 530 RERYL-SGSERAKRHGVLADFFSGTWSQGTKKLITL--PLVGKPLNL------------- 573
++ YL ++ + H +LAD+F G WS G +K L P + L+L
Sbjct: 742 QKLYLQDDNDLREMHTILADYFLGVWSGGRRKAFCLEDPYLNGCLDLENRSLLEEEKHFM 801
Query: 574 -----DRKVAPQPLWFSHT-------VANLRKLKELPYHLLHSGRLEELKQEVLGSMSWI 621
DR+ QP F N RK+ EL YHL G+ ++L ++ + SW+
Sbjct: 802 EQASFDRQAPDQPWVFQCNPLEPDIFFVNHRKMSELLYHLTRCGKTDDLLYGIIMNFSWL 861
Query: 622 SCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCRPAVELRGMERSLLYTELLARL 681
G + +L D +L + E+ + L+ + V L EL RL
Sbjct: 862 YTMIKIGQFDKVLSDIELAYNYSQEKELKFLANTLRSIKNKVT---AFPGSLSAELQQRL 918
Query: 682 HFFATSHPALVGQLCQQAQSWFQLCAHPVLVPLGGFLQPPGGPLRATLSGCHKGITAMAW 741
+S P L L + + + C+ +VPL + P R LS H +T +
Sbjct: 919 LPVVSSLPKLRHLLLECDKDGPKYCS---IVPLHSSMDVTYSPERLPLSSSHLHVTEILP 975
Query: 742 GVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 801
++ ++G ++ WD+E + ++ +T + +K+ + A+ + TL +
Sbjct: 976 TCNPSTVLTALENGSISTWDVETRQLLRQITTAQSVILGMKLTSDEKYLVVATTNNTLLI 1035
Query: 802 WN-----LLSGQE--------------KFTI-------WDGGSKNPAEPQI---WNLH-- 830
++ LLS E FT+ W SK+ + W L+
Sbjct: 1036 YDNVNSCLLSEVEIKGTKHGSSATYINGFTLSANHALAWLEASKDVTVIDLLYGWPLYQF 1095
Query: 831 --------VDEAHKVVYSASGSKINA---WNLETAEPVFHILGDASDPWM-CMAVLASQA 878
V + +Y+ G +N ++L + E + + + S ++ + +L +
Sbjct: 1096 HCWYEVTCVQCSLDGLYAFCGQYLNTTTIFHLGSGEKLCTVTSEFSGGFVKFLLILDTAQ 1155
Query: 879 TLLTVSRDGVVSLWSSA-TGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLV 937
++ V +G +S+W++ Q +E++ ++ + + V SI L+
Sbjct: 1156 EMVMVDSEGSLSVWNTEDISSPQLTDDFDCRREDSEVVSIELSEDQSAVLICKALSIELL 1215
Query: 938 SSKGDRLLEKL--PDAVRFL--VVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHE 993
+ ++ EK RF+ V+S++ + A + +F R + MA E
Sbjct: 1216 DTGLWKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFW-RRDTGQCMASLQEIS 1274
Query: 994 DMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVS--LLARGGALVAS 1051
+ V + +N++++ S ++ +W + + T + ++ G P+ LL G ++ S
Sbjct: 1275 GSIVKLVKSSHHNMLLSLSTSGVLSIWDI-DIITAMSNIDKTGKPIQSLLLPARGEIIYS 1333
Query: 1052 ASPQSSSFKVWDLSDA-------HRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVT 1104
K W+ S H V L TG V+ + DK+
Sbjct: 1334 LDGSDCVHK-WNFSSGFIEAVFKHEGIVEHCVLTSTGDIMVTSD----------DKSSQY 1382
Query: 1105 IWDLAEGE 1112
+W + GE
Sbjct: 1383 VWHTSSGE 1390
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 69.3 bits (168), Expect = 2e-11
Identities = 63/287 (21%), Positives = 117/287 (40%), Gaps = 36/287 (12%)
Query: 748 LVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSG 807
+ G+ D +W +E H GHT E+ C+ + TL + S D T LW++ +G
Sbjct: 150 IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNG 209
Query: 808 QEKFTIWDGGSKNPAEPQIWNLHVD-EAHKVVYSASGSKINAWNLETAEPVFHILG---- 862
+E +T+ +I +L + +++ + + W+ +T V ++G
Sbjct: 210 EEVYTL------RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263
Query: 863 --DASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKEETPTCAVS 918
AS W C + +LT S D LW + GK H I +
Sbjct: 264 ISSASFNWDC-------SLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDS------C 310
Query: 919 VQKQGKLV-TGFSNGSISLVSSKGDRLLEKLP----DAVRFLVVSEDESLLAAGFGRSVR 973
GKL+ T ++G+ + S+ + + KL + + + LL ++ R
Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370
Query: 974 IFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVW 1020
I+ A + + + H D + + F + N++ITGS D ++W
Sbjct: 371 IWDAQTGQCLQVLE---GHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 55.5 bits (132), Expect = 4e-07
Identities = 64/308 (20%), Positives = 123/308 (39%), Gaps = 26/308 (8%)
Query: 736 ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKI-FAKGTLANSAS 794
+T +A + G+ D +WD ++ L GH V + G + S
Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
Query: 795 KDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETA 854
D T LW++ +G+ T + AE + + ++ V + + W+++
Sbjct: 155 FDKTCKLWSVETGKCYHTF----RGHTAEIVCLSFN-PQSTLVATGSMDTTAKLWDIQNG 209
Query: 855 EPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGK----LQGKQHMSSIKE 910
E V+ + G +++ + ++ S ++T S D V +W + TG+ L G S
Sbjct: 210 EEVYTLRGHSAE-IISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSAS 268
Query: 911 ETPTCAV----SVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAA 966
C++ S+ K KL + ++ ++ D +L+ D L+ + A
Sbjct: 269 FNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTAR 328
Query: 967 GFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQG 1026
F + R +A G HE + F + N ++TGS D ++W ++ G
Sbjct: 329 IFSAATRKCIAKLEG----------HEGEISKISFNPQGNHLLTGSSDKTARIWD-AQTG 377
Query: 1027 TLLDILEG 1034
L +LEG
Sbjct: 378 QCLQVLEG 385
Score = 43.9 bits (102), Expect = 0.001
Identities = 88/424 (20%), Positives = 155/424 (36%), Gaps = 33/424 (7%)
Query: 913 PTCAVSVQKQGKLVTGFSNGSISLV----SSKGDRLLEKLPDAVRFLVVSEDESLLAAGF 968
P + +K G+L T SI L+ S+ L+E++ A L S E +
Sbjct: 13 PGIMLEYEKHGELKTK----SIDLLDLGPSTDVSALVEEIQKAEPLLTASRTEQVKLLIQ 68
Query: 969 GRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTL 1028
++ + F F + + A+ + ITGS D ++W + G
Sbjct: 69 RLQEKLGQNSNHTFYLFKVLKAHILPLTNVAL-NKSGSCFITGSYDRTCKLWDTAS-GEE 126
Query: 1029 LDILEGVGAPVSLLARG---GALVASASPQSSSFKVWDLSDAHRSRVPAPFLDRTG-LTA 1084
L+ LEG V +A G +A+ S + K+W + + F T +
Sbjct: 127 LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTC-KLWSVETG---KCYHTFRGHTAEIVC 182
Query: 1085 VSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSL-DTSSEIRCLEVAEQRKLLFTGLVSGV 1143
+S N +WD+ GEE +L S+EI L + TG
Sbjct: 183 LSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHT 242
Query: 1144 VLVFPLNSRQDVICIPPPEARKAINCMSLS-KCEDRLAIAYDNIVLVLDITSGDPCPVID 1202
V+V+ ++ + V + A I+ S + C L + D + D T+G +
Sbjct: 243 VVVWDADTGRKVNILIGHCAE--ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT 300
Query: 1203 GPRYTFYTQLPETLSSVAILTDYRVVYSMTNGDLFLYECATSKAFP-LETHRSRVACVEV 1261
G E L S T + + +G ++ AT K LE H ++ +
Sbjct: 301 GHD-------DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISF 353
Query: 1262 SHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRS 1321
+ + +++GS D +WD Q + + + + F+ V G KD +
Sbjct: 354 NPQGNHLLTGSSDKTARIWDAQTGQC---LQVLEGHTDEIFSCAFNYKGNIVITGSKDNT 410
Query: 1322 ILVW 1325
+W
Sbjct: 411 CRIW 414
Score = 42.7 bits (99), Expect = 0.002
Identities = 21/76 (27%), Positives = 36/76 (47%)
Query: 727 ATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAK 786
A L G I+ +++ + L+ G+ D +WD + + +L GHT E+ K
Sbjct: 339 AKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYK 398
Query: 787 GTLANSASKDYTLHLW 802
G + + SKD T +W
Sbjct: 399 GNIVITGSKDNTCRIW 414
Score = 40.4 bits (93), Expect = 0.012
Identities = 32/161 (19%), Positives = 62/161 (38%), Gaps = 14/161 (8%)
Query: 1182 AYDNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAILTDY--RVVYSMTNGDLFLY 1239
+YD + D SG+ ++G R Y ++A Y ++ + L+
Sbjct: 111 SYDRTCKLWDTASGEELNTLEGHRNVVY--------AIAFNNPYGDKIATGSFDKTCKLW 162
Query: 1240 ECATSKAF-PLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYC 1298
T K + H + + C+ + + LV +GS D LWD+Q + E+ +
Sbjct: 163 SVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGE---EVYTLRGHS 219
Query: 1299 RGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVH 1339
+ F+ + G D +++VW G + + H
Sbjct: 220 AEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGH 260
Score = 39.7 bits (91), Expect = 0.021
Identities = 23/86 (26%), Positives = 37/86 (43%)
Query: 723 GPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVK 782
G ATL+G I + KL+ + DG ++ + I L GH GE+ +
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
Query: 783 IFAKGTLANSASKDYTLHLWNLLSGQ 808
+G + S D T +W+ +GQ
Sbjct: 353 FNPQGNHLLTGSSDKTARIWDAQTGQ 378
Score = 33.9 bits (76), Expect = 1.2
Identities = 15/86 (17%), Positives = 38/86 (44%), Gaps = 3/86 (3%)
Query: 1245 KAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCA 1304
+ + L H + + + + +++GS D + +WD + +++ +C + A
Sbjct: 211 EVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR---KVNILIGHCAEISSA 267
Query: 1305 CFSKDDKYVYVGLKDRSILVWSVLDG 1330
F+ D + G D++ +W +G
Sbjct: 268 SFNWDCSLILTGSMDKTCKLWDATNG 293
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 67.0 bits (162), Expect = 1e-10
Identities = 66/275 (24%), Positives = 112/275 (40%), Gaps = 21/275 (7%)
Query: 765 QHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEP 824
Q I +L+GH GEV C K G+ SA D + LWN+ + + G S
Sbjct: 56 QAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHS-----G 110
Query: 825 QIWNLHVDEAHKVVYSASGSK-INAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTV 883
+ LH + +++SAS K + W+ ET E V + G S C + T
Sbjct: 111 AVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTG 170
Query: 884 SRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSV-QKQGKLVTGFSNGSISLVSSKGD 942
S DG V LW ++ K + + + AV+ ++++G + I + + +
Sbjct: 171 SDDGTVKLWD-----IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 943 RLLEKL---PDAVRFLVVSEDES-LLAAGFGRSVRI-----FLADSRGFRRFMAMDLEHE 993
+L + D+V L +S + S LL+ +VR+ F R + F E
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 994 DMVETAVFGTENNLIITGSLDALIQVWSLSEQGTL 1028
+ + + + I GS D + VW + + L
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL 320
Score = 44.3 bits (103), Expect = 9e-04
Identities = 50/232 (21%), Positives = 94/232 (40%), Gaps = 19/232 (8%)
Query: 727 ATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVR-CVKIFA 785
ATL G + + + + +L + D +AVWD E + L GHT V C
Sbjct: 103 ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARR 162
Query: 786 KGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSK 845
L + S D T+ LW++ ++K I + +N D + +++ +
Sbjct: 163 GPQLVCTGSDDGTVKLWDI---RKKAAIQTFQNTYQVLAVTFN---DTSDQIISGGIDND 216
Query: 846 INAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLW--------SSATG 897
I W+L + + + G A D +++ + + LL+ + D V +W
Sbjct: 217 IKVWDLRQNKLTYTMRGHA-DSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVK 275
Query: 898 KLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLP 949
QG H + ++ C+ S K+ G ++ + + + R+L KLP
Sbjct: 276 IFQGNVH--NFEKNLLRCSWS-PDGSKIAAGSADRFVYVWDTTSRRILYKLP 324
Score = 38.5 bits (88), Expect = 0.047
Identities = 17/68 (25%), Positives = 31/68 (45%)
Query: 734 KGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSA 793
K + +W + + G+ D + VWD + +++ L GH G + V + SA
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
Query: 794 SKDYTLHL 801
S D L++
Sbjct: 346 SSDKRLYM 353
Score = 33.1 bits (74), Expect = 2.0
Identities = 27/93 (29%), Positives = 40/93 (43%), Gaps = 5/93 (5%)
Query: 1249 LETHRSRV-ACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFS 1307
L+ H S V +C QLV +GS+D + LWD+ RK ++ ++Y V F+
Sbjct: 147 LKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI--RKKAAIQTFQNTY--QVLAVTFN 202
Query: 1308 KDDKYVYVGLKDRSILVWSVLDGTLLTVQFVHA 1340
+ G D I VW + L HA
Sbjct: 203 DTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHA 235
Score = 31.2 bits (69), Expect = 7.5
Identities = 20/95 (21%), Positives = 39/95 (41%), Gaps = 3/95 (3%)
Query: 1233 NGDLFLYECATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMS 1292
+G + L++ A + +V V + ++SG D + +WDL+ K + M
Sbjct: 173 DGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR 232
Query: 1293 YTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSV 1327
+ G+ S + Y+ D ++ VW V
Sbjct: 233 GHADSVTGLS---LSSEGSYLLSNAMDNTVRVWDV 264
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 64.3 bits (155), Expect = 8e-10
Identities = 84/337 (24%), Positives = 136/337 (40%), Gaps = 42/337 (12%)
Query: 713 PLGGFLQP----PGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVI 768
PLG P P P + LSG +T + + ++V ++D + VWD E
Sbjct: 84 PLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFE 143
Query: 769 HMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWN 828
L GHT V+ + G L S S D T+ LW+ G E G N + I
Sbjct: 144 RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWD-FQGFECIRTMHGHDHNVSSVAI-- 200
Query: 829 LHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLL-TVSRDG 887
+ +V ++ I W ++T V G W+ M TL+ + S D
Sbjct: 201 --MPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE--WVRMVRPNQDGTLIASCSNDQ 256
Query: 888 VVSLWSSAT----GKLQGKQHM------------SSIKEETPTCAVSVQKQGK----LVT 927
V +W AT +L+ +H+ SSI E T + +K GK L++
Sbjct: 257 TVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS---ETKKSGKPGPFLLS 313
Query: 928 GFSNGSISLVSSKGDRLLEKL---PDAVR-FLVVSEDESLLAAGFGRSVRIFLADSRGFR 983
G + +I + L L + VR L S + +L+ +++R++ D + +
Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW--DYKN-K 370
Query: 984 RFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVW 1020
R M HE V + F ++TGS+D ++VW
Sbjct: 371 RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 31.6 bits (70), Expect = 5.7
Identities = 21/83 (25%), Positives = 34/83 (40%), Gaps = 5/83 (6%)
Query: 1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYT-SSYCRGVQCACFS 1307
L+ H V + H +L+ S S D + LWD Q FE T + V
Sbjct: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQG----FECIRTMHGHDHNVSSVAIM 201
Query: 1308 KDDKYVYVGLKDRSILVWSVLDG 1330
+ ++ +D++I +W V G
Sbjct: 202 PNGDHIVSASRDKTIKMWEVQTG 224
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 62.8 bits (151), Expect = 2e-09
Identities = 54/217 (24%), Positives = 97/217 (44%), Gaps = 24/217 (11%)
Query: 737 TAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKD 796
T + EK +V G++D + VWD+E +H+L GH VRCV+ G S + D
Sbjct: 345 TVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYD 402
Query: 797 YTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEP 856
+ + +W+ + T+ G N ++++L D H VV + + I W++ET
Sbjct: 403 FMVKVWDPETETCLHTL--QGHTN----RVYSLQFDGIH-VVSGSLDTSIRVWDVETGNC 455
Query: 857 VFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGK----LQG-KQHMSSIKEE 911
+ + G S + + L++ + D V +W TG+ LQG +H S++
Sbjct: 456 IHTLTGHQS---LTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV--- 509
Query: 912 TPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKL 948
TC + ++T +G++ L K + L
Sbjct: 510 --TCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNL 542
Score = 49.7 bits (117), Expect = 2e-05
Identities = 63/320 (19%), Positives = 128/320 (40%), Gaps = 65/320 (20%)
Query: 748 LVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSG 807
+V G+ D + VW + L GHTG V ++ + + S S D TL +WN +G
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNAETG 333
Query: 808 QEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDP 867
+ T++ S + +H+ E +VV + + + W++ET + + ++G +
Sbjct: 334 ECIHTLYGHTS------TVRCMHLHE-KRVVSGSRDATLRVWDIETGQCLHVLMGHVA-- 384
Query: 868 WMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVT 927
V +++ + D +V +W ET TC ++Q V
Sbjct: 385 -AVRCVQYDGRRVVSGAYDFMVKVWD----------------PETETCLHTLQGHTNRVY 427
Query: 928 GFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMA 987
I +VS D S+R++ ++ +
Sbjct: 428 SLQFDGIHVVSGSLD---------------------------TSIRVWDVETGNCIHTLT 460
Query: 988 MDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVG---APVSLLAR 1044
H+ + T+ ++N++++G+ D+ +++W + + G L L+G + V+ L
Sbjct: 461 ---GHQSL--TSGMELKDNILVSGNADSTVKIWDI-KTGQCLQTLQGPNKHQSAVTCLQF 514
Query: 1045 GGALVASASPQSSSFKVWDL 1064
V ++S + K+WDL
Sbjct: 515 NKNFVITSS-DDGTVKLWDL 533
Score = 36.2 bits (82), Expect = 0.23
Identities = 47/233 (20%), Positives = 103/233 (44%), Gaps = 24/233 (10%)
Query: 1105 IWDLAEGEEQDSL-DTSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEA 1163
+W+ GE +L +S +RC+ + E+R + +G + V+ + + Q + + A
Sbjct: 327 VWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVA 384
Query: 1164 RKAINCMSLSKCEDRLAI--AYDNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAI 1221
A+ C+ + R + AYD +V V D + + G Y+ + + V+
Sbjct: 385 --AVRCVQY---DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSG 439
Query: 1222 LTDYRV-VYSMTNGDLFLYECATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLW 1280
D + V+ + G+ L H+S + +E+ K+ ++VSG+ D+ + +W
Sbjct: 440 SLDTSIRVWDVETGNCI---------HTLTGHQSLTSGMEL--KDNILVSGNADSTVKIW 488
Query: 1281 DLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLL 1333
D++ + + + + V C F+K+ +V D ++ +W + G +
Sbjct: 489 DIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFI 539
Score = 35.4 bits (80), Expect = 0.40
Identities = 46/198 (23%), Positives = 84/198 (42%), Gaps = 25/198 (12%)
Query: 1008 IITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKVWD---- 1063
+++GS DA ++VW + E G L +L G A V + G V S + KVWD
Sbjct: 356 VVSGSRDATLRVWDI-ETGQCLHVLMGHVAAVRCVQYDGRRVVSGA-YDFMVKVWDPETE 413
Query: 1064 ----LSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDT 1119
H +RV + L G+ VS GS + +WD+ G +L T
Sbjct: 414 TCLHTLQGHTNRVYS--LQFDGIHVVS--GSL--------DTSIRVWDVETGNCIHTL-T 460
Query: 1120 SSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIP-PPEARKAINCMSLSKCEDR 1178
+ + + +L +G V ++ + + Q + + P + + A+ C+ +K
Sbjct: 461 GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK-NFV 519
Query: 1179 LAIAYDNIVLVLDITSGD 1196
+ + D V + D+ +G+
Sbjct: 520 ITSSDDGTVKLWDLKTGE 537
Score = 35.0 bits (79), Expect = 0.52
Identities = 28/139 (20%), Positives = 57/139 (41%), Gaps = 8/139 (5%)
Query: 1226 RVVYSMTNGDLFLYECATSKAF-PLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQA 1284
R+V + L ++ T K L H V ++ ++ +++SGS D L +W+ +
Sbjct: 275 RIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNAET 332
Query: 1285 RKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVHAVVNR 1344
+ + +S R C +K V G +D ++ VW + G L V H R
Sbjct: 333 GECIHTLYGHTSTVR-----CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVR 387
Query: 1345 IIPTTSGFIAPTRHGYLIR 1363
+ + + ++++
Sbjct: 388 CVQYDGRRVVSGAYDFMVK 406
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 62.8 bits (151), Expect = 2e-09
Identities = 54/217 (24%), Positives = 97/217 (44%), Gaps = 24/217 (11%)
Query: 737 TAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKD 796
T + EK +V G++D + VWD+E +H+L GH VRCV+ G S + D
Sbjct: 463 TVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYD 520
Query: 797 YTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEP 856
+ + +W+ + T+ G N ++++L D H VV + + I W++ET
Sbjct: 521 FMVKVWDPETETCLHTL--QGHTN----RVYSLQFDGIH-VVSGSLDTSIRVWDVETGNC 573
Query: 857 VFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGK----LQG-KQHMSSIKEE 911
+ + G S + + L++ + D V +W TG+ LQG +H S++
Sbjct: 574 IHTLTGHQS---LTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV--- 627
Query: 912 TPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKL 948
TC + ++T +G++ L K + L
Sbjct: 628 --TCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNL 660
Score = 49.7 bits (117), Expect = 2e-05
Identities = 63/320 (19%), Positives = 128/320 (40%), Gaps = 65/320 (20%)
Query: 748 LVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSG 807
+V G+ D + VW + L GHTG V ++ + + S S D TL +WN +G
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNAETG 451
Query: 808 QEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDP 867
+ T++ S + +H+ E +VV + + + W++ET + + ++G +
Sbjct: 452 ECIHTLYGHTS------TVRCMHLHE-KRVVSGSRDATLRVWDIETGQCLHVLMGHVA-- 502
Query: 868 WMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVT 927
V +++ + D +V +W ET TC ++Q V
Sbjct: 503 -AVRCVQYDGRRVVSGAYDFMVKVWD----------------PETETCLHTLQGHTNRVY 545
Query: 928 GFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMA 987
I +VS D S+R++ ++ +
Sbjct: 546 SLQFDGIHVVSGSLD---------------------------TSIRVWDVETGNCIHTLT 578
Query: 988 MDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVG---APVSLLAR 1044
H+ + T+ ++N++++G+ D+ +++W + + G L L+G + V+ L
Sbjct: 579 ---GHQSL--TSGMELKDNILVSGNADSTVKIWDI-KTGQCLQTLQGPNKHQSAVTCLQF 632
Query: 1045 GGALVASASPQSSSFKVWDL 1064
V ++S + K+WDL
Sbjct: 633 NKNFVITSS-DDGTVKLWDL 651
Score = 36.2 bits (82), Expect = 0.23
Identities = 47/233 (20%), Positives = 103/233 (44%), Gaps = 24/233 (10%)
Query: 1105 IWDLAEGEEQDSL-DTSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEA 1163
+W+ GE +L +S +RC+ + E+R + +G + V+ + + Q + + A
Sbjct: 445 VWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVA 502
Query: 1164 RKAINCMSLSKCEDRLAI--AYDNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAI 1221
A+ C+ + R + AYD +V V D + + G Y+ + + V+
Sbjct: 503 --AVRCVQY---DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSG 557
Query: 1222 LTDYRV-VYSMTNGDLFLYECATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLW 1280
D + V+ + G+ L H+S + +E+ K+ ++VSG+ D+ + +W
Sbjct: 558 SLDTSIRVWDVETGNCI---------HTLTGHQSLTSGMEL--KDNILVSGNADSTVKIW 606
Query: 1281 DLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLL 1333
D++ + + + + V C F+K+ +V D ++ +W + G +
Sbjct: 607 DIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFI 657
Score = 35.4 bits (80), Expect = 0.40
Identities = 46/198 (23%), Positives = 84/198 (42%), Gaps = 25/198 (12%)
Query: 1008 IITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKVWD---- 1063
+++GS DA ++VW + E G L +L G A V + G V S + KVWD
Sbjct: 474 VVSGSRDATLRVWDI-ETGQCLHVLMGHVAAVRCVQYDGRRVVSGA-YDFMVKVWDPETE 531
Query: 1064 ----LSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDT 1119
H +RV + L G+ VS GS + +WD+ G +L T
Sbjct: 532 TCLHTLQGHTNRVYS--LQFDGIHVVS--GSL--------DTSIRVWDVETGNCIHTL-T 578
Query: 1120 SSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIP-PPEARKAINCMSLSKCEDR 1178
+ + + +L +G V ++ + + Q + + P + + A+ C+ +K
Sbjct: 579 GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK-NFV 637
Query: 1179 LAIAYDNIVLVLDITSGD 1196
+ + D V + D+ +G+
Sbjct: 638 ITSSDDGTVKLWDLKTGE 655
Score = 35.0 bits (79), Expect = 0.52
Identities = 28/139 (20%), Positives = 57/139 (41%), Gaps = 8/139 (5%)
Query: 1226 RVVYSMTNGDLFLYECATSKAF-PLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQA 1284
R+V + L ++ T K L H V ++ ++ +++SGS D L +W+ +
Sbjct: 393 RIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNAET 450
Query: 1285 RKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVHAVVNR 1344
+ + +S R C +K V G +D ++ VW + G L V H R
Sbjct: 451 GECIHTLYGHTSTVR-----CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVR 505
Query: 1345 IIPTTSGFIAPTRHGYLIR 1363
+ + + ++++
Sbjct: 506 CVQYDGRRVVSGAYDFMVK 524
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 62.8 bits (151), Expect = 2e-09
Identities = 54/217 (24%), Positives = 97/217 (44%), Gaps = 24/217 (11%)
Query: 737 TAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKD 796
T + EK +V G++D + VWD+E +H+L GH VRCV+ G S + D
Sbjct: 383 TVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYD 440
Query: 797 YTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEP 856
+ + +W+ + T+ G N ++++L D H VV + + I W++ET
Sbjct: 441 FMVKVWDPETETCLHTL--QGHTN----RVYSLQFDGIH-VVSGSLDTSIRVWDVETGNC 493
Query: 857 VFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGK----LQG-KQHMSSIKEE 911
+ + G S + + L++ + D V +W TG+ LQG +H S++
Sbjct: 494 IHTLTGHQS---LTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV--- 547
Query: 912 TPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKL 948
TC + ++T +G++ L K + L
Sbjct: 548 --TCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNL 580
Score = 49.7 bits (117), Expect = 2e-05
Identities = 63/320 (19%), Positives = 128/320 (40%), Gaps = 65/320 (20%)
Query: 748 LVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSG 807
+V G+ D + VW + L GHTG V ++ + + S S D TL +WN +G
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNAETG 371
Query: 808 QEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDP 867
+ T++ S + +H+ E +VV + + + W++ET + + ++G +
Sbjct: 372 ECIHTLYGHTS------TVRCMHLHE-KRVVSGSRDATLRVWDIETGQCLHVLMGHVA-- 422
Query: 868 WMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVT 927
V +++ + D +V +W ET TC ++Q V
Sbjct: 423 -AVRCVQYDGRRVVSGAYDFMVKVWD----------------PETETCLHTLQGHTNRVY 465
Query: 928 GFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMA 987
I +VS D S+R++ ++ +
Sbjct: 466 SLQFDGIHVVSGSLD---------------------------TSIRVWDVETGNCIHTLT 498
Query: 988 MDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVG---APVSLLAR 1044
H+ + T+ ++N++++G+ D+ +++W + + G L L+G + V+ L
Sbjct: 499 ---GHQSL--TSGMELKDNILVSGNADSTVKIWDI-KTGQCLQTLQGPNKHQSAVTCLQF 552
Query: 1045 GGALVASASPQSSSFKVWDL 1064
V ++S + K+WDL
Sbjct: 553 NKNFVITSS-DDGTVKLWDL 571
Score = 36.2 bits (82), Expect = 0.23
Identities = 47/233 (20%), Positives = 103/233 (44%), Gaps = 24/233 (10%)
Query: 1105 IWDLAEGEEQDSL-DTSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEA 1163
+W+ GE +L +S +RC+ + E+R + +G + V+ + + Q + + A
Sbjct: 365 VWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVA 422
Query: 1164 RKAINCMSLSKCEDRLAI--AYDNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAI 1221
A+ C+ + R + AYD +V V D + + G Y+ + + V+
Sbjct: 423 --AVRCVQY---DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSG 477
Query: 1222 LTDYRV-VYSMTNGDLFLYECATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLW 1280
D + V+ + G+ L H+S + +E+ K+ ++VSG+ D+ + +W
Sbjct: 478 SLDTSIRVWDVETGNCI---------HTLTGHQSLTSGMEL--KDNILVSGNADSTVKIW 526
Query: 1281 DLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLL 1333
D++ + + + + V C F+K+ +V D ++ +W + G +
Sbjct: 527 DIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFI 577
Score = 35.4 bits (80), Expect = 0.40
Identities = 46/198 (23%), Positives = 84/198 (42%), Gaps = 25/198 (12%)
Query: 1008 IITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKVWD---- 1063
+++GS DA ++VW + E G L +L G A V + G V S + KVWD
Sbjct: 394 VVSGSRDATLRVWDI-ETGQCLHVLMGHVAAVRCVQYDGRRVVSGA-YDFMVKVWDPETE 451
Query: 1064 ----LSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDT 1119
H +RV + L G+ VS GS + +WD+ G +L T
Sbjct: 452 TCLHTLQGHTNRVYS--LQFDGIHVVS--GSL--------DTSIRVWDVETGNCIHTL-T 498
Query: 1120 SSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIP-PPEARKAINCMSLSKCEDR 1178
+ + + +L +G V ++ + + Q + + P + + A+ C+ +K
Sbjct: 499 GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK-NFV 557
Query: 1179 LAIAYDNIVLVLDITSGD 1196
+ + D V + D+ +G+
Sbjct: 558 ITSSDDGTVKLWDLKTGE 575
Score = 35.0 bits (79), Expect = 0.52
Identities = 28/139 (20%), Positives = 57/139 (41%), Gaps = 8/139 (5%)
Query: 1226 RVVYSMTNGDLFLYECATSKAF-PLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQA 1284
R+V + L ++ T K L H V ++ ++ +++SGS D L +W+ +
Sbjct: 313 RIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNAET 370
Query: 1285 RKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVHAVVNR 1344
+ + +S R C +K V G +D ++ VW + G L V H R
Sbjct: 371 GECIHTLYGHTSTVR-----CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVR 425
Query: 1345 IIPTTSGFIAPTRHGYLIR 1363
+ + + ++++
Sbjct: 426 CVQYDGRRVVSGAYDFMVK 444
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 60.5 bits (145), Expect = 1e-08
Identities = 39/176 (22%), Positives = 76/176 (43%), Gaps = 5/176 (2%)
Query: 723 GPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVK 782
G T+SG GI+ +AW + LLV + D + +WD+ + L GH+ V C
Sbjct: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136
Query: 783 IFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSAS 842
+ L S S D ++ +W++ +G+ T+ +P +N + +V S+
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTL--PAHSDPVSAVHFN---RDGSLIVSSSY 191
Query: 843 GSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGK 898
W+ + + + ++ D + P + + +L + D + LW + GK
Sbjct: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 247
Score = 49.3 bits (116), Expect = 3e-05
Identities = 39/178 (21%), Positives = 82/178 (46%), Gaps = 6/178 (3%)
Query: 721 PGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRC 780
P L+ TL+G K ++++ + + L + D ++ +W + ++GH +
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92
Query: 781 VKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYS 840
V + L SAS D TL +W++ SG+ T+ G N +N +++ +V
Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL--KGHSNYVFCCNFN---PQSNLIVSG 147
Query: 841 ASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGK 898
+ + W+++T + L SDP + + +++ S DG+ +W +A+G+
Sbjct: 148 SFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Score = 45.1 bits (105), Expect = 5e-04
Identities = 60/259 (23%), Positives = 110/259 (42%), Gaps = 18/259 (6%)
Query: 771 LTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLH 830
L GHT V VK G S+S D + +W G+ + TI G K W+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI--SGHKLGISDVAWS-- 96
Query: 831 VDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVS 890
+++ +V ++ + W++ + + + + G ++ + C S +++ S D V
Sbjct: 97 -SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL-IVSGSFDESVR 154
Query: 891 LWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFS-NGSISLVSSKGDRLLEKLP 949
+W TGK S P AV + G L+ S +G + + + L+ L
Sbjct: 155 IWDVKTGKCLKTLPAHS----DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
Query: 950 D----AVRFLVVSED-ESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFG-T 1003
D V F+ S + + +LAA +++++ S+G ++E A F T
Sbjct: 211 DDDNPPVSFVKFSPNGKYILAATLDNTLKLW-DYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Query: 1004 ENNLIITGSLDALIQVWSL 1022
I++GS D L+ +W+L
Sbjct: 270 GGKWIVSGSEDNLVYIWNL 288
Score = 43.1 bits (100), Expect = 0.002
Identities = 45/178 (25%), Positives = 69/178 (38%), Gaps = 12/178 (6%)
Query: 723 GPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGE-VRCV 781
G TL ++A+ + + L+V + DG+ +WD + L V V
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 782 KIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSA 841
K G +A+ D TL LW+ G+ T G KN N V +V +
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT--GHKNEKYCIFANFSVTGGKWIVSGS 278
Query: 842 SGSKINAWNLETAEPVFHILG--DASDPWMCMA---VLASQATLLTVSRDGVVSLWSS 894
+ + WNL+T E V + G D C ++AS A + D + LW S
Sbjct: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA----LENDKTIKLWKS 332
Score = 39.7 bits (91), Expect = 0.021
Identities = 46/204 (22%), Positives = 84/204 (41%), Gaps = 37/204 (18%)
Query: 880 LLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSS 939
L + S D ++ +W + GK + +S K G +S+ S LVS+
Sbjct: 60 LASSSADKLIKIWGAYDGKFEK--------------TISGHKLGISDVAWSSDSNLLVSA 105
Query: 940 KGDRLLEKLPDA---------------VRFLVVSEDESLLAAG-FGRSVRIFLADSRGFR 983
D+ L K+ D V + +L+ +G F SVRI+ +
Sbjct: 106 SDDKTL-KIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 164
Query: 984 RFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLL- 1042
+ + H D V F + +LI++ S D L ++W + L +++ PVS +
Sbjct: 165 KTLPA---HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 1043 -ARGGALVASASPQSSSFKVWDLS 1065
+ G + +A+ ++ K+WD S
Sbjct: 222 FSPNGKYILAAT-LDNTLKLWDYS 244
Score = 38.1 bits (87), Expect = 0.061
Identities = 52/285 (18%), Positives = 114/285 (40%), Gaps = 25/285 (8%)
Query: 1051 SASPQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAE 1110
++S K+W D + + + G++ V+ + D + IWD++
Sbjct: 61 ASSSADKLIKIWGAYDGKFEKTISGH--KLGISDVAWSSDSNLLVSASDDKTLKIWDVSS 118
Query: 1111 GEEQDSLDTSSE-IRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARKAINC 1169
G+ +L S + C Q L+ +G V ++ + + + + +P ++
Sbjct: 119 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHS--DPVSA 176
Query: 1170 MSLSKCEDRL-AIAYDNIVLVLDITSGDPCPVI---DGPRYTFYTQLPETLSSVAILTDY 1225
+ ++ + + +YD + + D SG + D P +F P +A D
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD- 235
Query: 1226 RVVYSMTNGDLFLYECATSKAFPLET-HRSRVACVEVSHKE---QLVVSGSEDALLCLWD 1281
L L++ + K T H++ C+ + + +VSGSED L+ +W+
Sbjct: 236 --------NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287
Query: 1282 LQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLK-DRSILVW 1325
LQ ++ ++ + + AC ++ L+ D++I +W
Sbjct: 288 LQTKEIVQKLQGHTDVV--ISTACHPTENIIASAALENDKTIKLW 330
Score = 35.8 bits (81), Expect = 0.30
Identities = 27/120 (22%), Positives = 54/120 (45%), Gaps = 5/120 (4%)
Query: 1216 LSSVAILTDYRVVYSMTNGD-LFLYECATSKAFP-LETHRSRVACVEVSHKEQLVVSGSE 1273
+S VA +D ++ S ++ L +++ ++ K L+ H + V C + + L+VSGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 1274 DALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLL 1333
D + +WD++ K + ++ V F++D + D +W G L
Sbjct: 150 DESVRIWDVKTGKC---LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206
Score = 35.0 bits (79), Expect = 0.52
Identities = 22/88 (25%), Positives = 39/88 (44%), Gaps = 7/88 (7%)
Query: 722 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCV 781
G L+ + + ++ + + K ++ T D + +WD + + TGH E C
Sbjct: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC- 261
Query: 782 KIFAK-----GTLANSASKDYTLHLWNL 804
IFA G S S+D +++WNL
Sbjct: 262 -IFANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 31.6 bits (70), Expect = 5.7
Identities = 24/103 (23%), Positives = 40/103 (38%), Gaps = 3/103 (2%)
Query: 1238 LYECATSKAFP-LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSS 1296
+++ T K L H V+ V + L+VS S D L +WD + + + +
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 1297 YCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVH 1339
V FS + KY+ D ++ +W G L H
Sbjct: 215 --PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 60.5 bits (145), Expect = 1e-08
Identities = 39/176 (22%), Positives = 76/176 (43%), Gaps = 5/176 (2%)
Query: 723 GPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVK 782
G T+SG GI+ +AW + LLV + D + +WD+ + L GH+ V C
Sbjct: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136
Query: 783 IFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSAS 842
+ L S S D ++ +W++ +G+ T+ +P +N + +V S+
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTL--PAHSDPVSAVHFN---RDGSLIVSSSY 191
Query: 843 GSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGK 898
W+ + + + ++ D + P + + +L + D + LW + GK
Sbjct: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 247
Score = 49.3 bits (116), Expect = 3e-05
Identities = 39/178 (21%), Positives = 82/178 (46%), Gaps = 6/178 (3%)
Query: 721 PGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRC 780
P L+ TL+G K ++++ + + L + D ++ +W + ++GH +
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92
Query: 781 VKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYS 840
V + L SAS D TL +W++ SG+ T+ G N +N +++ +V
Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL--KGHSNYVFCCNFN---PQSNLIVSG 147
Query: 841 ASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGK 898
+ + W+++T + L SDP + + +++ S DG+ +W +A+G+
Sbjct: 148 SFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Score = 45.1 bits (105), Expect = 5e-04
Identities = 60/259 (23%), Positives = 110/259 (42%), Gaps = 18/259 (6%)
Query: 771 LTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLH 830
L GHT V VK G S+S D + +W G+ + TI G K W+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI--SGHKLGISDVAWS-- 96
Query: 831 VDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVS 890
+++ +V ++ + W++ + + + + G ++ + C S +++ S D V
Sbjct: 97 -SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL-IVSGSFDESVR 154
Query: 891 LWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFS-NGSISLVSSKGDRLLEKLP 949
+W TGK S P AV + G L+ S +G + + + L+ L
Sbjct: 155 IWDVKTGKCLKTLPAHS----DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
Query: 950 D----AVRFLVVSED-ESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFG-T 1003
D V F+ S + + +LAA +++++ S+G ++E A F T
Sbjct: 211 DDDNPPVSFVKFSPNGKYILAATLDNTLKLW-DYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Query: 1004 ENNLIITGSLDALIQVWSL 1022
I++GS D L+ +W+L
Sbjct: 270 GGKWIVSGSEDNLVYIWNL 288
Score = 43.1 bits (100), Expect = 0.002
Identities = 45/178 (25%), Positives = 69/178 (38%), Gaps = 12/178 (6%)
Query: 723 GPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGE-VRCV 781
G TL ++A+ + + L+V + DG+ +WD + L V V
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 782 KIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSA 841
K G +A+ D TL LW+ G+ T G KN N V +V +
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT--GHKNEKYCIFANFSVTGGKWIVSGS 278
Query: 842 SGSKINAWNLETAEPVFHILG--DASDPWMCMA---VLASQATLLTVSRDGVVSLWSS 894
+ + WNL+T E V + G D C ++AS A + D + LW S
Sbjct: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA----LENDKTIKLWKS 332
Score = 39.7 bits (91), Expect = 0.021
Identities = 46/204 (22%), Positives = 84/204 (41%), Gaps = 37/204 (18%)
Query: 880 LLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSS 939
L + S D ++ +W + GK + +S K G +S+ S LVS+
Sbjct: 60 LASSSADKLIKIWGAYDGKFEK--------------TISGHKLGISDVAWSSDSNLLVSA 105
Query: 940 KGDRLLEKLPDA---------------VRFLVVSEDESLLAAG-FGRSVRIFLADSRGFR 983
D+ L K+ D V + +L+ +G F SVRI+ +
Sbjct: 106 SDDKTL-KIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 164
Query: 984 RFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLL- 1042
+ + H D V F + +LI++ S D L ++W + L +++ PVS +
Sbjct: 165 KTLPA---HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 1043 -ARGGALVASASPQSSSFKVWDLS 1065
+ G + +A+ ++ K+WD S
Sbjct: 222 FSPNGKYILAAT-LDNTLKLWDYS 244
Score = 38.1 bits (87), Expect = 0.061
Identities = 52/285 (18%), Positives = 114/285 (40%), Gaps = 25/285 (8%)
Query: 1051 SASPQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAE 1110
++S K+W D + + + G++ V+ + D + IWD++
Sbjct: 61 ASSSADKLIKIWGAYDGKFEKTISGH--KLGISDVAWSSDSNLLVSASDDKTLKIWDVSS 118
Query: 1111 GEEQDSLDTSSE-IRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARKAINC 1169
G+ +L S + C Q L+ +G V ++ + + + + +P ++
Sbjct: 119 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHS--DPVSA 176
Query: 1170 MSLSKCEDRL-AIAYDNIVLVLDITSGDPCPVI---DGPRYTFYTQLPETLSSVAILTDY 1225
+ ++ + + +YD + + D SG + D P +F P +A D
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD- 235
Query: 1226 RVVYSMTNGDLFLYECATSKAFPLET-HRSRVACVEVSHKE---QLVVSGSEDALLCLWD 1281
L L++ + K T H++ C+ + + +VSGSED L+ +W+
Sbjct: 236 --------NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287
Query: 1282 LQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLK-DRSILVW 1325
LQ ++ ++ + + AC ++ L+ D++I +W
Sbjct: 288 LQTKEIVQKLQGHTDVV--ISTACHPTENIIASAALENDKTIKLW 330
Score = 35.8 bits (81), Expect = 0.30
Identities = 27/120 (22%), Positives = 54/120 (45%), Gaps = 5/120 (4%)
Query: 1216 LSSVAILTDYRVVYSMTNGD-LFLYECATSKAFP-LETHRSRVACVEVSHKEQLVVSGSE 1273
+S VA +D ++ S ++ L +++ ++ K L+ H + V C + + L+VSGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 1274 DALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLL 1333
D + +WD++ K + ++ V F++D + D +W G L
Sbjct: 150 DESVRIWDVKTGKC---LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206
Score = 35.0 bits (79), Expect = 0.52
Identities = 22/88 (25%), Positives = 39/88 (44%), Gaps = 7/88 (7%)
Query: 722 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCV 781
G L+ + + ++ + + K ++ T D + +WD + + TGH E C
Sbjct: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC- 261
Query: 782 KIFAK-----GTLANSASKDYTLHLWNL 804
IFA G S S+D +++WNL
Sbjct: 262 -IFANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 31.6 bits (70), Expect = 5.7
Identities = 24/103 (23%), Positives = 40/103 (38%), Gaps = 3/103 (2%)
Query: 1238 LYECATSKAFP-LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSS 1296
+++ T K L H V+ V + L+VS S D L +WD + + + +
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 1297 YCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVH 1339
V FS + KY+ D ++ +W G L H
Sbjct: 215 --PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 59.7 bits (143), Expect = 2e-08
Identities = 56/231 (24%), Positives = 100/231 (43%), Gaps = 24/231 (10%)
Query: 726 RATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFA 785
+ +LSG + GIT++ + L+ + D +W +++ + H LTGH+G+V K
Sbjct: 359 KGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLL 418
Query: 786 KGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNP---AEPQIWNLHVDEAHKVVYSAS 842
S S D TL LW+L S T++ G S N E + + H D+
Sbjct: 419 DNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDK--------- 469
Query: 843 GSKINAWNLETAEPV--FHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQ 900
KI W++ + V +LG + + + + LL+ SRD ++ + T ++
Sbjct: 470 --KIRFWDIRSESIVREMELLGKIT----ALDLNPERTELLSCSRDDLLKVIDLRTNAIK 523
Query: 901 GKQHMSSIKEETPTCAVSVQKQGKLV-TGFSNGSI---SLVSSKGDRLLEK 947
K + V G V G + GS+ S+++ K +++L K
Sbjct: 524 QTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSK 574
Score = 38.1 bits (87), Expect = 0.061
Identities = 50/217 (23%), Positives = 84/217 (38%), Gaps = 29/217 (13%)
Query: 725 LRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIF 784
LR TL+G + + + ++ +V G+ D + +WD+ + I + + C I
Sbjct: 400 LRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS---CNDIV 456
Query: 785 AKGTLANSASKDYTLHLWNLLSGQ--------EKFTIWDGGSKNPAEPQIWNLHVDEAHK 836
S D + W++ S K T D NP ++ + D+ K
Sbjct: 457 CTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALD---LNPERTELLSCSRDDLLK 513
Query: 837 VVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSAT 896
V+ + NA + P F D W + + + S +G + +WS T
Sbjct: 514 VI----DLRTNAIKQTFSAPGFKCGSD----WTRVVFSPDGSYVAAGSAEGSLYIWSVLT 565
Query: 897 GKLQ---GKQHMSSIK----EETPTCAVSVQKQGKLV 926
GK++ KQH SSI + + VSV K K V
Sbjct: 566 GKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAV 602
Score = 33.1 bits (74), Expect = 2.0
Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 1255 RVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQC-ACFSKDDKYV 1313
++ ++++ + ++S S D LL + DL+ K S C FS D YV
Sbjct: 490 KITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYV 549
Query: 1314 YVGLKDRSILVWSVLDG 1330
G + S+ +WSVL G
Sbjct: 550 AAGSAEGSLYIWSVLTG 566
Score = 32.7 bits (73), Expect = 2.6
Identities = 22/79 (27%), Positives = 34/79 (43%), Gaps = 6/79 (7%)
Query: 1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSK 1308
L H +V + +VSGS D L LWDL++ K + + S C + C
Sbjct: 404 LTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS-KVCIKTVFAGSSCNDIVCT---- 458
Query: 1309 DDKYVYVGLKDRSILVWSV 1327
++ V G D+ I W +
Sbjct: 459 -EQCVMSGHFDKKIRFWDI 476
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 59.7 bits (143), Expect = 2e-08
Identities = 56/231 (24%), Positives = 100/231 (43%), Gaps = 24/231 (10%)
Query: 726 RATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFA 785
+ +LSG + GIT++ + L+ + D +W +++ + H LTGH+G+V K
Sbjct: 340 KGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLL 399
Query: 786 KGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNP---AEPQIWNLHVDEAHKVVYSAS 842
S S D TL LW+L S T++ G S N E + + H D+
Sbjct: 400 DNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDK--------- 450
Query: 843 GSKINAWNLETAEPV--FHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQ 900
KI W++ + V +LG + + + + LL+ SRD ++ + T ++
Sbjct: 451 --KIRFWDIRSESIVREMELLGKIT----ALDLNPERTELLSCSRDDLLKVIDLRTNAIK 504
Query: 901 GKQHMSSIKEETPTCAVSVQKQGKLV-TGFSNGSI---SLVSSKGDRLLEK 947
K + V G V G + GS+ S+++ K +++L K
Sbjct: 505 QTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSK 555
Score = 38.1 bits (87), Expect = 0.061
Identities = 50/217 (23%), Positives = 84/217 (38%), Gaps = 29/217 (13%)
Query: 725 LRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIF 784
LR TL+G + + + ++ +V G+ D + +WD+ + I + + C I
Sbjct: 381 LRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS---CNDIV 437
Query: 785 AKGTLANSASKDYTLHLWNLLSGQ--------EKFTIWDGGSKNPAEPQIWNLHVDEAHK 836
S D + W++ S K T D NP ++ + D+ K
Sbjct: 438 CTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALD---LNPERTELLSCSRDDLLK 494
Query: 837 VVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSAT 896
V+ + NA + P F D W + + + S +G + +WS T
Sbjct: 495 VI----DLRTNAIKQTFSAPGFKCGSD----WTRVVFSPDGSYVAAGSAEGSLYIWSVLT 546
Query: 897 GKLQ---GKQHMSSIK----EETPTCAVSVQKQGKLV 926
GK++ KQH SSI + + VSV K K V
Sbjct: 547 GKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAV 583
Score = 33.1 bits (74), Expect = 2.0
Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 1255 RVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQC-ACFSKDDKYV 1313
++ ++++ + ++S S D LL + DL+ K S C FS D YV
Sbjct: 471 KITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYV 530
Query: 1314 YVGLKDRSILVWSVLDG 1330
G + S+ +WSVL G
Sbjct: 531 AAGSAEGSLYIWSVLTG 547
Score = 32.7 bits (73), Expect = 2.6
Identities = 22/79 (27%), Positives = 34/79 (43%), Gaps = 6/79 (7%)
Query: 1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSK 1308
L H +V + +VSGS D L LWDL++ K + + S C + C
Sbjct: 385 LTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS-KVCIKTVFAGSSCNDIVCT---- 439
Query: 1309 DDKYVYVGLKDRSILVWSV 1327
++ V G D+ I W +
Sbjct: 440 -EQCVMSGHFDKKIRFWDI 457
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [Homo
sapiens]
Length = 340
Score = 58.5 bits (140), Expect = 4e-08
Identities = 76/348 (21%), Positives = 134/348 (38%), Gaps = 40/348 (11%)
Query: 694 QLCQQAQSWFQLCAHPVLVPLGGFLQPPGG---PLRATLSGCHKGITAMAWGVEEKLLVI 750
QL Q Q + C LV + + G R TL G I AM WG + +LLV
Sbjct: 13 QLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYAMHWGYDSRLLVS 72
Query: 751 GTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEK 810
+QDG + +WD + +H + + V G D ++NL + +
Sbjct: 73 ASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGN 132
Query: 811 FTIWDGGSKNPAEPQIWNL--HVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPW 868
+ + P + +D++ ++V S+ + W++ETA+ G + D
Sbjct: 133 VRV---SRELPGHTGYLSCCRFLDDS-QIVTSSGDTTCALWDIETAQQTTTFTGHSGDV- 187
Query: 869 MCMAVLASQATLLTVSRDGVVSLWSSATGKLQGK--QHMSSIKEETPTCAVSVQKQG-KL 925
M +++ T ++ + D LW G + H+S I AVS G
Sbjct: 188 MSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDIN------AVSFFPNGYAF 241
Query: 926 VTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDE---SLLAAGFGRSVRIFLADSRGF 982
TG + + L + D+ L L+ S D + + F +S R+ LA F
Sbjct: 242 ATGSDDATCRLFDLRADQEL---------LLYSHDNIICGITSVAFSKSGRLLLAGYDDF 292
Query: 983 RRFMAMDLE---------HEDMVETAVFGTENNLIITGSLDALIQVWS 1021
+ L+ H++ V + + TGS D+ +++W+
Sbjct: 293 NCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Score = 35.4 bits (80), Expect = 0.40
Identities = 23/79 (29%), Positives = 35/79 (44%), Gaps = 1/79 (1%)
Query: 1252 HRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDK 1311
H S + V +GS+DA L+DL+A + S+ + C G+ FSK +
Sbjct: 225 HVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIIC-GITSVAFSKSGR 283
Query: 1312 YVYVGLKDRSILVWSVLDG 1330
+ G D + VW L G
Sbjct: 284 LLLAGYDDFNCNVWDTLKG 302
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 58.5 bits (140), Expect = 4e-08
Identities = 77/339 (22%), Positives = 127/339 (37%), Gaps = 22/339 (6%)
Query: 694 QLCQQAQSWFQLCAHPVLVPLGGFLQPPGGP---LRATLSGCHKGITAMAWGVEEKLLVI 750
QL +Q + CA L L L+ G R TL G I AM W + KLLV
Sbjct: 13 QLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVS 72
Query: 751 GTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEK 810
+QDG + VWD + +H + + V G D ++NL S +
Sbjct: 73 ASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGN 132
Query: 811 FTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMC 870
+ S + D + +V S+ + W++ET + +G D C
Sbjct: 133 VKVSRELSAHTGYLSCCRFLDD--NNIVTSSGDTTCALWDIETGQQKTVFVGHTGD---C 187
Query: 871 MAVLASQATLLTVSR--DGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLV-T 927
M++ S L +S D LW +G + E+ A+ G+ + T
Sbjct: 188 MSLAVSPDFNLFISGACDASAKLWDVR----EGTCRQTFTGHESDINAICFFPNGEAICT 243
Query: 928 GFSNGSISLVSSKGDRLL-----EKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGF 982
G + S L + D+ L E + + + S LL AG+ + DS
Sbjct: 244 GSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYD-DFNCNVWDSMKS 302
Query: 983 RRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWS 1021
R + H++ V + + TGS D+ +++W+
Sbjct: 303 ERVGILS-GHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 33.1 bits (74), Expect = 2.0
Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Query: 1252 HRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDK 1311
H S + + + + +GS+DA L+DL+A + S+ S C G+ FS +
Sbjct: 225 HESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIIC-GITSVAFSLSGR 283
Query: 1312 YVYVGLKDRSILVW 1325
++ G D + VW
Sbjct: 284 LLFAGYDDFNCNVW 297
Score = 32.3 bits (72), Expect = 3.4
Identities = 26/119 (21%), Positives = 50/119 (42%), Gaps = 2/119 (1%)
Query: 1223 TDYRVVYSMT-NGDLFLYEC-ATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLW 1280
TD +++ S + +G L +++ T+K + S V + V G D + ++
Sbjct: 65 TDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIY 124
Query: 1281 DLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVH 1339
+L++R+ ++S S G C DD + D + +W + G TV H
Sbjct: 125 NLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGH 183
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [Homo
sapiens]
Length = 340
Score = 58.2 bits (139), Expect = 6e-08
Identities = 71/345 (20%), Positives = 132/345 (38%), Gaps = 34/345 (9%)
Query: 694 QLCQQAQSWFQLCAHPVLVPLGGFLQPPGG---PLRATLSGCHKGITAMAWGVEEKLLVI 750
QL Q + + C L + L P G R TL G I AM WG + +LLV
Sbjct: 13 QLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVS 72
Query: 751 GTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEK 810
+QDG + +WD + +H + + V G D +++L + +
Sbjct: 73 ASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGN 132
Query: 811 FTIWDGGSKNPAEPQIWN-LHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWM 869
+ + P + + ++++ S+ + W++ET + G + D M
Sbjct: 133 VRV---SRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDV-M 188
Query: 870 CMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQG-KLVTG 928
+++ T ++ + D + LW + + I E+ AV+ G TG
Sbjct: 189 SLSLAPDGRTFVSGACDASIKLWDVRDSMCR----QTFIGHESDINAVAFFPNGYAFTTG 244
Query: 929 FSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDE---SLLAAGFGRSVRIFLA--DSRGFR 983
+ + L + D+ L L+ S D + + F RS R+ LA D
Sbjct: 245 SDDATCRLFDLRADQEL---------LMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCN 295
Query: 984 RFMAMDLE-------HEDMVETAVFGTENNLIITGSLDALIQVWS 1021
+ AM + H++ V + + TGS D+ +++W+
Sbjct: 296 IWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 34.3 bits (77), Expect = 0.88
Identities = 20/79 (25%), Positives = 35/79 (44%), Gaps = 1/79 (1%)
Query: 1252 HRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDK 1311
H S + V +GS+DA L+DL+A + S+ + C G+ FS+ +
Sbjct: 225 HESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIIC-GITSVAFSRSGR 283
Query: 1312 YVYVGLKDRSILVWSVLDG 1330
+ G D + +W + G
Sbjct: 284 LLLAGYDDFNCNIWDAMKG 302
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 56.6 bits (135), Expect = 2e-07
Identities = 78/361 (21%), Positives = 134/361 (37%), Gaps = 65/361 (18%)
Query: 725 LRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIF 784
L G +T + + + K L G+ D + VW M+ Q + TGH V CV
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 785 AKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLH-VDEAHKVVYSASG 843
G L S S+D T+ +W + + + + T++ + + ++H + V ++
Sbjct: 71 PSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTAT-----VRSVHFCSDGQSFVTASDD 124
Query: 844 SKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLL-TVSRDGVVSLWSSATGKLQGK 902
+ W + +F + + W+ A + L+ + S D V LW ++ +
Sbjct: 125 KTVKVWATHRQKFLFSLSQHIN--WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE---- 178
Query: 903 QHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDES 962
C S + G VT ++ P
Sbjct: 179 ------------CVHSYCEHGGFVT----------------YVDFHPSGT---------C 201
Query: 963 LLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSL 1022
+ AAG +V+++ D R R L H V F N +IT S D+ +++ L
Sbjct: 202 IAAAGMDNTVKVW--DVRTHRLLQHYQL-HSAAVNGLSFHPSGNYLITASSDSTLKILDL 258
Query: 1023 SEQGTLLDILEGVGAPVSLLA--RGGALVASASPQ------SSSFKVWDLSDAHRSRVPA 1074
E G LL L G P + +A R G AS S+F + D + ++VP
Sbjct: 259 ME-GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEV--TKVPR 315
Query: 1075 P 1075
P
Sbjct: 316 P 316
Score = 41.2 bits (95), Expect = 0.007
Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 7/76 (9%)
Query: 1252 HRSRVACVEVSHKEQLVVSGSEDALLCLWDL--QARKWKFEMSYTSSYCRGVQCACFSKD 1309
HR V CV+ S + + SGS D+ L +W + Q+R ++F + + V C FS
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF-----TGHKDAVTCVNFSPS 72
Query: 1310 DKYVYVGLKDRSILVW 1325
+ G +D+++ +W
Sbjct: 73 GHLLASGSRDKTVRIW 88
Score = 38.9 bits (89), Expect = 0.036
Identities = 52/251 (20%), Positives = 102/251 (40%), Gaps = 14/251 (5%)
Query: 866 DPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKL 925
D C+ + L + S D + +W K Q + + + ++ TC V+ G L
Sbjct: 20 DAVTCVDFSINTKQLASGSMDSCLMVWHM---KPQSRAYRFTGHKDAVTC-VNFSPSGHL 75
Query: 926 VTGFSNGS---ISLVSSKGDRLLEKLPDAVRFLV--VSEDESLLAAGFGRSVRIFLADSR 980
+ S I + + KG+ + + A V S+ +S + A ++V+++ +
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135
Query: 981 GFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVS 1040
+F+ +H + V A F + LI++ S D +++W S + + E G
Sbjct: 136 ---KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY 192
Query: 1041 LLARGGALVASASPQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDK 1100
+ +A+ ++ KVWD+ HR + L + +S + S Y
Sbjct: 193 VDFHPSGTCIAAAGMDNTVKVWDVR-THR-LLQHYQLHSAAVNGLSFHPSGNYLITASSD 250
Query: 1101 NKVTIWDLAEG 1111
+ + I DL EG
Sbjct: 251 STLKILDLMEG 261
Score = 36.6 bits (83), Expect = 0.18
Identities = 32/109 (29%), Positives = 45/109 (41%), Gaps = 10/109 (9%)
Query: 1247 FPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRG---VQC 1303
F L H + V C + S +L+VS S+D + LWD +R+ SYC V
Sbjct: 139 FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE------CVHSYCEHGGFVTY 192
Query: 1304 ACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVH-AVVNRIIPTTSG 1351
F + D ++ VW V LL +H A VN + SG
Sbjct: 193 VDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
Score = 35.8 bits (81), Expect = 0.30
Identities = 21/83 (25%), Positives = 36/83 (43%), Gaps = 3/83 (3%)
Query: 1244 SKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQC 1303
S+A+ H+ V CV S L+ SGS D + +W K E + ++ V+
Sbjct: 52 SRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW---VPNVKGESTVFRAHTATVRS 108
Query: 1304 ACFSKDDKYVYVGLKDRSILVWS 1326
F D + D+++ VW+
Sbjct: 109 VHFCSDGQSFVTASDDKTVKVWA 131
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 56.6 bits (135), Expect = 2e-07
Identities = 78/361 (21%), Positives = 134/361 (37%), Gaps = 65/361 (18%)
Query: 725 LRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIF 784
L G +T + + + K L G+ D + VW M+ Q + TGH V CV
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 785 AKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLH-VDEAHKVVYSASG 843
G L S S+D T+ +W + + + + T++ + + ++H + V ++
Sbjct: 71 PSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTAT-----VRSVHFCSDGQSFVTASDD 124
Query: 844 SKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLL-TVSRDGVVSLWSSATGKLQGK 902
+ W + +F + + W+ A + L+ + S D V LW ++ +
Sbjct: 125 KTVKVWATHRQKFLFSLSQHIN--WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE---- 178
Query: 903 QHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDES 962
C S + G VT ++ P
Sbjct: 179 ------------CVHSYCEHGGFVT----------------YVDFHPSGT---------C 201
Query: 963 LLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSL 1022
+ AAG +V+++ D R R L H V F N +IT S D+ +++ L
Sbjct: 202 IAAAGMDNTVKVW--DVRTHRLLQHYQL-HSAAVNGLSFHPSGNYLITASSDSTLKILDL 258
Query: 1023 SEQGTLLDILEGVGAPVSLLA--RGGALVASASPQ------SSSFKVWDLSDAHRSRVPA 1074
E G LL L G P + +A R G AS S+F + D + ++VP
Sbjct: 259 ME-GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEV--TKVPR 315
Query: 1075 P 1075
P
Sbjct: 316 P 316
Score = 41.2 bits (95), Expect = 0.007
Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 7/76 (9%)
Query: 1252 HRSRVACVEVSHKEQLVVSGSEDALLCLWDL--QARKWKFEMSYTSSYCRGVQCACFSKD 1309
HR V CV+ S + + SGS D+ L +W + Q+R ++F + + V C FS
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF-----TGHKDAVTCVNFSPS 72
Query: 1310 DKYVYVGLKDRSILVW 1325
+ G +D+++ +W
Sbjct: 73 GHLLASGSRDKTVRIW 88
Score = 38.9 bits (89), Expect = 0.036
Identities = 52/251 (20%), Positives = 102/251 (40%), Gaps = 14/251 (5%)
Query: 866 DPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKL 925
D C+ + L + S D + +W K Q + + + ++ TC V+ G L
Sbjct: 20 DAVTCVDFSINTKQLASGSMDSCLMVWHM---KPQSRAYRFTGHKDAVTC-VNFSPSGHL 75
Query: 926 VTGFSNGS---ISLVSSKGDRLLEKLPDAVRFLV--VSEDESLLAAGFGRSVRIFLADSR 980
+ S I + + KG+ + + A V S+ +S + A ++V+++ +
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135
Query: 981 GFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVS 1040
+F+ +H + V A F + LI++ S D +++W S + + E G
Sbjct: 136 ---KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY 192
Query: 1041 LLARGGALVASASPQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDK 1100
+ +A+ ++ KVWD+ HR + L + +S + S Y
Sbjct: 193 VDFHPSGTCIAAAGMDNTVKVWDVR-THR-LLQHYQLHSAAVNGLSFHPSGNYLITASSD 250
Query: 1101 NKVTIWDLAEG 1111
+ + I DL EG
Sbjct: 251 STLKILDLMEG 261
Score = 36.6 bits (83), Expect = 0.18
Identities = 32/109 (29%), Positives = 45/109 (41%), Gaps = 10/109 (9%)
Query: 1247 FPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRG---VQC 1303
F L H + V C + S +L+VS S+D + LWD +R+ SYC V
Sbjct: 139 FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE------CVHSYCEHGGFVTY 192
Query: 1304 ACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVH-AVVNRIIPTTSG 1351
F + D ++ VW V LL +H A VN + SG
Sbjct: 193 VDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
Score = 35.8 bits (81), Expect = 0.30
Identities = 21/83 (25%), Positives = 36/83 (43%), Gaps = 3/83 (3%)
Query: 1244 SKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQC 1303
S+A+ H+ V CV S L+ SGS D + +W K E + ++ V+
Sbjct: 52 SRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW---VPNVKGESTVFRAHTATVRS 108
Query: 1304 ACFSKDDKYVYVGLKDRSILVWS 1326
F D + D+++ VW+
Sbjct: 109 VHFCSDGQSFVTASDDKTVKVWA 131
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 55.5 bits (132), Expect = 4e-07
Identities = 41/185 (22%), Positives = 74/185 (40%), Gaps = 23/185 (12%)
Query: 723 GPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVK 782
G TL G + I+ +AW + LV + D + +WD+ + L GH+ V C
Sbjct: 73 GKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN 132
Query: 783 IFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSAS 842
L S S D T+ +W + +G+ T+ + H D V ++ S
Sbjct: 133 FNPPSNLIISGSFDETVKIWEVKTGKCLKTL--------------SAHSDPVSAVHFNCS 178
Query: 843 GSKI---------NAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWS 893
GS I W+ + + + ++ D + P + + +LT + D + LW
Sbjct: 179 GSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD 238
Query: 894 SATGK 898
+ G+
Sbjct: 239 YSRGR 243
Score = 49.7 bits (117), Expect = 2e-05
Identities = 41/179 (22%), Positives = 81/179 (45%), Gaps = 8/179 (4%)
Query: 721 PGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRC 780
P L+ TL G + ++++ + + L + D ++ +W + L GH E+
Sbjct: 29 PNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISD 88
Query: 781 VKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYS 840
V + + SAS D TL LW++ SG+ T+ G N ++ + + ++ S
Sbjct: 89 VAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL--KGHSN----YVFCCNFNPPSNLIIS 142
Query: 841 AS-GSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGK 898
S + W ++T + L SDP + S + +++ S DG+ +W +A+G+
Sbjct: 143 GSFDETVKIWEVKTGK-CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ 200
Score = 41.2 bits (95), Expect = 0.007
Identities = 38/192 (19%), Positives = 84/192 (43%), Gaps = 13/192 (6%)
Query: 880 LLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSS 939
L + S D ++ +W + GK + + ++ E A S +LV+ + ++ L
Sbjct: 56 LASSSADRLIIIWGAYDGKYEKTLYGHNL--EISDVAWS-SDSSRLVSASDDKTLKLWDV 112
Query: 940 KGDRLLEKLPDAVRFLVVSE----DESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDM 995
+ + L+ L ++ +++ F +V+I+ + + ++ H D
Sbjct: 113 RSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSA---HSDP 169
Query: 996 VETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLL--ARGGALVASAS 1053
V F +LI++GS D L ++W + L +++ PVS + + G + +A+
Sbjct: 170 VSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTAT 229
Query: 1054 PQSSSFKVWDLS 1065
++ K+WD S
Sbjct: 230 -LDNTLKLWDYS 240
Score = 38.5 bits (88), Expect = 0.047
Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 3/89 (3%)
Query: 1252 HRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDK 1311
H ++ V S +VS S+D L LWD+++ K + S+Y V C F+
Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNY---VFCCNFNPPSN 138
Query: 1312 YVYVGLKDRSILVWSVLDGTLLTVQFVHA 1340
+ G D ++ +W V G L H+
Sbjct: 139 LIISGSFDETVKIWEVKTGKCLKTLSAHS 167
Score = 35.8 bits (81), Expect = 0.30
Identities = 17/59 (28%), Positives = 31/59 (52%), Gaps = 2/59 (3%)
Query: 746 KLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSAS--KDYTLHLW 802
K +V G++D ++ +W+++ + ++ L GHT V L SA+ D T+ LW
Sbjct: 268 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 35.4 bits (80), Expect = 0.40
Identities = 27/103 (26%), Positives = 40/103 (38%), Gaps = 3/103 (2%)
Query: 1238 LYECATSKAFP-LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSS 1296
++E T K L H V+ V + L+VSGS D L +WD A + +
Sbjct: 151 IWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD--AASGQCLKTLVDD 208
Query: 1297 YCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVH 1339
V FS + KY+ D ++ +W G L H
Sbjct: 209 DNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGH 251
Score = 34.7 bits (78), Expect = 0.68
Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 7/64 (10%)
Query: 746 KLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAK-----GTLANSASKDYTLH 800
K ++ T D + +WD + TGH E C IFA G S S+D ++
Sbjct: 223 KYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYC--IFANFSVTGGKWIVSGSEDNLVY 280
Query: 801 LWNL 804
+WNL
Sbjct: 281 IWNL 284
Score = 34.3 bits (77), Expect = 0.88
Identities = 47/238 (19%), Positives = 95/238 (39%), Gaps = 25/238 (10%)
Query: 1099 DKNKVTIWDLAEGEEQDSLDTSSE-IRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVIC 1157
D + +WD+ G+ +L S + C L+ +G V ++ + + + C
Sbjct: 103 DDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK---C 159
Query: 1158 IPPPEARKAINCMSLSKCEDRLAIA--YDNIVLVLDITSGDPCPVI---DGPRYTFYTQL 1212
+ A C L ++ YD + + D SG + D P +F
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFS 219
Query: 1213 PETLSSVAILTDYRVVYSMTNGDLFLYECATSKAFPLET-HRSRVACVEVSHKE---QLV 1268
P + ILT + + L L++ + + T H++ C+ + + +
Sbjct: 220 P---NGKYILT------ATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWI 270
Query: 1269 VSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLK-DRSILVW 1325
VSGSED L+ +W+LQ ++ ++ + + AC ++ L+ D++I +W
Sbjct: 271 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVV--ISAACHPTENLIASAALENDKTIKLW 326
Score = 33.9 bits (76), Expect = 1.2
Identities = 28/120 (23%), Positives = 52/120 (43%), Gaps = 5/120 (4%)
Query: 1216 LSSVAILTDY-RVVYSMTNGDLFLYECATSKAFP-LETHRSRVACVEVSHKEQLVVSGSE 1273
+S VA +D R+V + + L L++ + K L+ H + V C + L++SGS
Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSF 145
Query: 1274 DALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLL 1333
D + +W+++ K + S++ V F+ + G D +W G L
Sbjct: 146 DETVKIWEVKTGKC---LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCL 202
>gi|55769546 PAK1 interacting protein 1 [Homo sapiens]
Length = 392
Score = 55.1 bits (131), Expect = 5e-07
Identities = 47/199 (23%), Positives = 88/199 (44%), Gaps = 17/199 (8%)
Query: 748 LVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSG 807
L+ G +DG++ +WD ++ + + H G+V + I G LA S D TL WNL+ G
Sbjct: 96 LISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEG 155
Query: 808 QEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDP 867
+ F K A W+ ++ ++ +KI+ + L+TA I G ++
Sbjct: 156 RSAFI---KNIKQNAHIVEWSPRGEQYVVIIQ----NKIDIYQLDTAS----ISGTITNE 204
Query: 868 WMCMAVLASQATLLTVSRDGVVSLW---SSATGKLQGKQHMSSIKEETPTCAVSVQKQGK 924
+V ++L V+ D V + S + K H + +K+ + + +
Sbjct: 205 KRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKD---MFSFEIPEHHV 261
Query: 925 LVTGFSNGSISLVSSKGDR 943
+V+ S+G I + K D+
Sbjct: 262 IVSASSDGFIKMWKLKQDK 280
Score = 40.0 bits (92), Expect = 0.016
Identities = 63/289 (21%), Positives = 119/289 (41%), Gaps = 61/289 (21%)
Query: 740 AWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTL 799
A V + +V G++D + ++DM+++ L H+G + C+K + L S ++D +
Sbjct: 47 AVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLI-SGAEDGLI 105
Query: 800 HLWNLLSGQEKFTIWDG-GSKNPAEPQIWNLHVDEAHKVVYSASGSK-INAWNLETAEPV 857
+W+ W+ S + Q+ L + + K+ S K + WNL
Sbjct: 106 CIWDAKK-------WECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNL------ 152
Query: 858 FHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAV 917
V A + + ++ + WS +G+Q++ I+ +
Sbjct: 153 ---------------VEGRSAFIKNIKQNAHIVEWSP-----RGEQYVVIIQNKIDIY-- 190
Query: 918 SVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLA-AGFGRSVRIFL 976
+L T +G+I+ EK +V+FL ES+LA AG +R F
Sbjct: 191 ------QLDTASISGTIT---------NEKRISSVKFL----SESVLAVAGDEEVIRFFD 231
Query: 977 ADSR-GFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSE 1024
DS F A + +DM + E+++I++ S D I++W L +
Sbjct: 232 CDSLVCLCEFKAHENRVKDMFSFEI--PEHHVIVSASSDGFIKMWKLKQ 278
Score = 36.2 bits (82), Expect = 0.23
Identities = 28/117 (23%), Positives = 58/117 (49%), Gaps = 6/117 (5%)
Query: 1215 TLSSVAILTDYRVVYSMTNGDLFLYECATS-KAFPLETHRSRVACVEVSHKEQLVVSGSE 1273
+LS+VA+ + + VV + + +Y+ + L H + C++ L+ SG+E
Sbjct: 44 SLSAVAVNSRF-VVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLI-SGAE 101
Query: 1274 DALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDG 1330
D L+C+WD A+KW+ S + + + + VG D+++ W++++G
Sbjct: 102 DGLICIWD--AKKWECLKSIKAHKGQVTFLSIHPSGKLALSVG-TDKTLRTWNLVEG 155
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 55.1 bits (131), Expect = 5e-07
Identities = 74/370 (20%), Positives = 142/370 (38%), Gaps = 49/370 (13%)
Query: 736 ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGT--LANSA 793
+ MA+ LL G DG + VWD+ + H G G V V T L S+
Sbjct: 112 VATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSS 171
Query: 794 SKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINA----- 848
+ D + +W+L Q++ + + H + +SA G + +
Sbjct: 172 ATDAAIRVWSL---QDRSCL-----------AVLTAHYSAVTSLAFSADGHTMLSSGRDK 217
Query: 849 ----WNLETAE-----PVFHILGDA----SDPWMCMAVLASQATLLTVSRDGVVSLWSSA 895
W+L++ + PVF + A +P + V + LT G + +W +A
Sbjct: 218 ICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAA 277
Query: 896 TGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPD----- 950
+G+ Q + T G ++T ++ ++ L ++ RL ++
Sbjct: 278 SGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEV 337
Query: 951 -AVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLII 1009
VRFL ED ++ A +++F + + H D+V + L
Sbjct: 338 LDVRFL-GPEDSHVVVASNSPCLKVFELQTSACQILHG----HTDIVLALDVFRKGWLFA 392
Query: 1010 TGSLDALIQVWSLSEQGTLLDILEGVGAPVSL----LARGGALVASASPQSSSFKVWDLS 1065
+ + D +++W +++ G ++ + +G G S+ +R Q + K+W L
Sbjct: 393 SCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLP 452
Query: 1066 DAHRSRVPAP 1075
A S+ AP
Sbjct: 453 KALLSKNTAP 462
Score = 48.9 bits (115), Expect = 3e-05
Identities = 48/191 (25%), Positives = 78/191 (40%), Gaps = 16/191 (8%)
Query: 720 PPGGPL---RATLSGCH-KGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHT 775
P GP+ T CH K I ++A +KLL G+QD +W + + ++ + +GH
Sbjct: 462 PDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHR 521
Query: 776 GEVRCVKIFAKGTLANSASKDYTLHLWNL--LSGQEKFTIWDGGSKNPAEPQIWNLHVDE 833
+ CV+ + +AS D T+ LW L S + F D A V
Sbjct: 522 RGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVA-------FVSR 574
Query: 834 AHKVVYSASGSKINAWNLETAEPVFHILGDASDPW-MCMAVLASQATLLTVSRDGVVSLW 892
+++ S S + W ++ E V + W + + L A LT + D V LW
Sbjct: 575 GTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHA--LTGASDSRVILW 632
Query: 893 SSATGKLQGKQ 903
T Q ++
Sbjct: 633 KDVTEAEQAEE 643
Score = 45.1 bits (105), Expect = 5e-04
Identities = 60/297 (20%), Positives = 115/297 (38%), Gaps = 26/297 (8%)
Query: 742 GVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 801
G E+ +V+ + + V++++ +L GHT V + +F KG L S +KD ++ +
Sbjct: 344 GPEDSHVVVASNSPCLKVFELQTS-ACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRI 402
Query: 802 WNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNL-------ETA 854
W + + + G + + + E+ +V + + W L TA
Sbjct: 403 WRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESF-LVTGSQDCTVKLWPLPKALLSKNTA 461
Query: 855 EPVFHILGDASDPWMC-------MAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSS 907
IL A C +A+ + L T S+D LW+ +L G + S
Sbjct: 462 PDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLG---VFS 518
Query: 908 IKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKL----PDAVRFLVVSEDESL 963
C L T ++G+I L + + L+ ++ VS L
Sbjct: 519 GHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQL 578
Query: 964 LAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVW 1020
L++G V+++ + R + HED V ++ +TG+ D+ + +W
Sbjct: 579 LSSGSDGLVKLWTIKNNECVRTLD---AHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Score = 44.3 bits (103), Expect = 9e-04
Identities = 64/330 (19%), Positives = 119/330 (36%), Gaps = 58/330 (17%)
Query: 1007 LIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKVWDLSD 1066
L+ + + DA I+VWSL ++ L + A SL +S + +WDL
Sbjct: 167 LLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQS 226
Query: 1067 AHRSR-VP-------APFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLD 1118
+R VP A L ++ + +YF GD+ + +W+ A G+
Sbjct: 227 CQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQ------ 280
Query: 1119 TSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARKAINCMSLSKCEDR 1178
C+ Q PP ++ +C
Sbjct: 281 ------CVYTQAQ---------------------------PPGPGQELTHCTLAHTAGVV 307
Query: 1179 LAIAYDNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAIL--TDYRVVYSMTNGDL 1236
L D+ +L+ + S + ++ Y+ E + V L D VV + + L
Sbjct: 308 LTATADHNLLLYEARS-----LRLQKQFAGYS---EEVLDVRFLGPEDSHVVVASNSPCL 359
Query: 1237 FLYECATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSS 1296
++E TS L H V ++V K L S ++D + +W + ++ S
Sbjct: 360 KVFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSG 419
Query: 1297 YCRGVQCACFSK-DDKYVYVGLKDRSILVW 1325
+ V C S+ + ++ G +D ++ +W
Sbjct: 420 HTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449
Score = 37.7 bits (86), Expect = 0.080
Identities = 97/565 (17%), Positives = 199/565 (35%), Gaps = 102/565 (18%)
Query: 831 VDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVS 890
+D+ + ++ G+++N + + + + + + + L+T SR +++
Sbjct: 32 LDQTGQHLFCVCGTRVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLA 91
Query: 891 LWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLV-TGFSNGSI---SLVSSKGDRLLE 946
W+ G + + P ++ L+ TG +G++ +V G
Sbjct: 92 QWAWQEGSVT---RLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFR 148
Query: 947 KLPDAVRFLVVSEDES---LLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGT 1003
P V + D + L ++ ++R++ R +A+ H V + F
Sbjct: 149 GSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSC---LAVLTAHYSAVTSLAFSA 205
Query: 1004 ENNLIITGSLDALIQVWSLSE-QGT-LLDILEGVGAPVSLLARGGALVASASP------- 1054
+ + +++ D + +W L Q T + + E V A V L + + SP
Sbjct: 206 DGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTA 265
Query: 1055 -QSSSFKVWDLSDAH----RSRVPAPFLDRTG----------LTAVSHNGSYVYFPKIGD 1099
+ +VW+ + +++ P P + T LTA + + +Y +
Sbjct: 266 GDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLR 325
Query: 1100 KNKVTIWDLAE-------GEEQDSLDTSSEIRCLEVAE---------------------- 1130
K E G E + +S CL+V E
Sbjct: 326 LQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVF 385
Query: 1131 QRKLLFTGLVSGV-VLVFPLNSRQDVICIPPPEARK-AINCMSLSKCEDRLAIAYDNIVL 1188
++ LF V ++ +N V+C+ ++ + S+ ++ +
Sbjct: 386 RKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLV------- 438
Query: 1189 VLDITSGDPCPVIDGPRYTFYTQLPETLSSVAILTDYRVVYSMTNGDLFLYECATSKAFP 1248
T C V P LP+ L S D NG + L T +
Sbjct: 439 ----TGSQDCTVKLWP-------LPKALLSKNTAPD--------NGPILLQAQTTQRC-- 477
Query: 1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSK 1308
H + V ++ ++L+ +GS+D LW L + + S + RG+ C FS
Sbjct: 478 ---HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQL---LGVFSGHRRGLWCVQFSP 531
Query: 1309 DDKYVYVGLKDRSILVWSVLDGTLL 1333
D+ + D +I +W++ D + L
Sbjct: 532 MDQVLATASADGTIKLWALQDFSCL 556
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [Homo
sapiens]
Length = 340
Score = 53.9 bits (128), Expect = 1e-06
Identities = 68/344 (19%), Positives = 126/344 (36%), Gaps = 32/344 (9%)
Query: 694 QLCQQAQSWFQLCAHPVLVPLGGFLQPPGG---PLRATLSGCHKGITAMAWGVEEKLLVI 750
QL Q + + CA L + + P G R TL G I AM WG + +LLV
Sbjct: 13 QLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVS 72
Query: 751 GTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEK 810
+QDG + +WD + +H + + V G D ++NL + +
Sbjct: 73 ASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGN 132
Query: 811 FTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMC 870
+ + + D +++V S+ + W++ET + G D M
Sbjct: 133 VRVSRELAGHTGYLSCCRFLDD--NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDV-MS 189
Query: 871 MAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGK-LVTGF 929
+++ ++ + D LW +G + E+ A+ G TG
Sbjct: 190 LSLAPDTRLFVSGACDASAKLWDVR----EGMCRQTFTGHESDINAICFFPNGNAFATGS 245
Query: 930 SNGSISLVSSKGDRLLEKLPDAVRFLVVSEDE---SLLAAGFGRSVRIFLADSRGFRRFM 986
+ + L + D+ L + S D + + F +S R+ LA F +
Sbjct: 246 DDATCRLFDLRADQEL---------MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNV 296
Query: 987 AMDLE---------HEDMVETAVFGTENNLIITGSLDALIQVWS 1021
L+ H++ V + + TGS D+ +++W+
Sbjct: 297 WDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 33.5 bits (75), Expect = 1.5
Identities = 21/77 (27%), Positives = 34/77 (44%), Gaps = 1/77 (1%)
Query: 1252 HRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDK 1311
H S + + +GS+DA L+DL+A + S+ + C G+ FSK +
Sbjct: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIIC-GITSVSFSKSGR 283
Query: 1312 YVYVGLKDRSILVWSVL 1328
+ G D + VW L
Sbjct: 284 LLLAGYDDFNCNVWDAL 300
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 53.1 bits (126), Expect = 2e-06
Identities = 102/476 (21%), Positives = 163/476 (34%), Gaps = 49/476 (10%)
Query: 717 FLQPPGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTG 776
F Q G + L I +A+ V ++ +G D ++ +W E + H G
Sbjct: 1826 FFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHG 1885
Query: 777 EVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHK 836
V G +A +D + +W+ GS + +L + A
Sbjct: 1886 FVAAALFLHAGCQLLTAGEDGKVQVWS-------------GSLGRPRGHLGSLSLSPALS 1932
Query: 837 VVYSASGSKINAWNLETAEPVFHI-------LGDASDPWMCMAVLASQATLLTVSRDGVV 889
V S G ++ ++ I G A D + S L++ + DG +
Sbjct: 1933 VALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSL 1992
Query: 890 SLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLP 949
W+ LQ +S ++ A S Q L + + ++ L + K
Sbjct: 1993 QGWALKECSLQSLWLLSRFQKPVLGLATS---QELLASASEDFTVQLWPRQLLTRPHKAE 2049
Query: 950 D------------AVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRR---FMAMDLEHED 994
D V S D LA G GR + D R + + H D
Sbjct: 2050 DFPCGTELRGHEGPVSCCSFSTDGGSLATG-GRDRSLLCWDVRTPKTPVLIHSFPACHRD 2108
Query: 995 MVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASP 1054
V T T++NL+I+ S D + +W E G L G + VS +A V S S
Sbjct: 2109 WV-TGCAWTKDNLLISCSSDGSVGLWD-PESGQRLGQFLGHQSAVSAVAAVEEHVVSVS- 2165
Query: 1055 QSSSFKVWDLSDAHRSRVPA---PFLDRTGL---TAVSHNGSYVYFPKIGDKNKVTIW-D 1107
+ + KVWD + +PA P A GS + +G +W
Sbjct: 2166 RDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHP 2225
Query: 1108 LAEGEEQDSLDTSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEA 1163
L + L S +R V+E L+ T G V ++ + D CIP A
Sbjct: 2226 LLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSA 2281
Score = 46.6 bits (109), Expect = 2e-04
Identities = 74/279 (26%), Positives = 113/279 (40%), Gaps = 24/279 (8%)
Query: 206 GPPGIGKTALMCKLAEQMPRLLGHKTVTVL--RLLGTSQMSSDARGLLKSICFQVCLAYG 263
G G GKTA + L + G K +++ G A LL+ +C L
Sbjct: 1168 GQSGQGKTAFLASLVSALQAPDGAKVASLVFFHFSGARPDQGLALTLLRRLC--TYLRGQ 1225
Query: 264 LPLPPAQVLDAHTRVVQFFHTLL--HTVSCRNFESLVLLLDAMDDLDSVRHARRVPWLPL 321
L P A + V + LL S ++ VL++D D L W+P
Sbjct: 1226 LKEPGALPSTYRSLVWELQQRLLPKSAESLHPGQTQVLIIDGADRLVDQNGQLISDWIPK 1285
Query: 322 NCPPRVHLILSACSGALGVLDTLQRVLLDPEAYWEVKPLSGNQGQQMI--QLLLAAARRT 379
P VHL+LS S A G+ +TL++ + PL + +++ +L L R
Sbjct: 1286 KLPRCVHLVLSVSSDA-GLGETLEQ--SQGAHVLALGPLEASARARLVREELALYGKRLE 1342
Query: 380 LSPVHTDL-LWASLPECGNPGRLRLAFEEARKWASF--------TVPVPLATTAEEATHQ 430
SP + + L E G P LRL + R + + T+P AT H
Sbjct: 1343 ESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLRTLP---ATVPLLLQHI 1399
Query: 431 LCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSL 469
L T LE+ HG ++ L + +R GL+ +L VLS+
Sbjct: 1400 LST-LEKEHGPDVLPQALTALEVTRSGLTVDQLHGVLSV 1437
Score = 40.0 bits (92), Expect = 0.016
Identities = 47/168 (27%), Positives = 74/168 (44%), Gaps = 20/168 (11%)
Query: 1170 MSLSKCEDRLAIAYD-NIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAILTDYRVV 1228
++LS DR+A+ Y + + + I+SG + L +S++A L+ +V
Sbjct: 1933 VALSPDGDRVAVGYRADGIRIYKISSGS--------QGAQGQALDVAVSALAWLSPKVLV 1984
Query: 1229 YSMTNGDL---FLYECATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQ-- 1283
+G L L EC+ + L + V + S ++L+ S SED + LW Q
Sbjct: 1985 SGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATS--QELLASASEDFTVQLWPRQLL 2042
Query: 1284 ARKWKFEMSYTSSYCRG----VQCACFSKDDKYVYVGLKDRSILVWSV 1327
R K E + RG V C FS D + G +DRS+L W V
Sbjct: 2043 TRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDV 2090
Score = 37.4 bits (85), Expect = 0.10
Identities = 98/434 (22%), Positives = 160/434 (36%), Gaps = 69/434 (15%)
Query: 594 LKELPYHLLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVR 653
L +LPYHLL SG RG+ + L + + A HL E+GLV
Sbjct: 1542 LGDLPYHLLQSGN-----------------RGL---LSKFLTNLHVVAAHL---ELGLVS 1578
Query: 654 EALQLCRPAVELRGMERSLLYTELLARLHFFATSHPALVGQLCQQAQSWFQLCAHPVLVP 713
L+ E L +A F +++ Q +P L+P
Sbjct: 1579 RLLEAHALYASSVPKEEQKLPEADVAVFRTFLRQQASILSQ-------------YPRLLP 1625
Query: 714 LGGFLQPPGGPLRATLSGCHKG-ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLT 772
QP PL CH+ + + W ++ L + M+ Q +
Sbjct: 1626 QQAANQPLDSPL------CHQASLLSRRWHLQHTLRWLNKPR------TMKNQQSSSLSL 1673
Query: 773 GHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVD 832
+ V G A + + T++L +L + QE+ ++ G A L +
Sbjct: 1674 AVSSSPTAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISA-----CLFLS 1728
Query: 833 EAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLL-TVSRDGVVSL 891
+ + +A + W+L+ V C L+ LL TV G + L
Sbjct: 1729 D-DTLFLTAFDGLLELWDLQHGCRVLQTKAHQYQITGCC--LSPDCRLLATVCLGGCLKL 1785
Query: 892 WSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLV-TGFSNGSISLVSSKGDRLLEKL-- 948
W + G+L QH ++ C V+ +G+++ TG GSIS G ++ + L
Sbjct: 1786 WDTVRGQL-AFQHTYP---KSLNC-VAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGA 1840
Query: 949 PDA-VRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNL 1007
P A +R L + ++A G S+ A G R +A H V A+F
Sbjct: 1841 PGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGAR--LAAFPAHHGFVAAALFLHAGCQ 1898
Query: 1008 IITGSLDALIQVWS 1021
++T D +QVWS
Sbjct: 1899 LLTAGEDGKVQVWS 1912
Score = 32.7 bits (73), Expect = 2.6
Identities = 23/97 (23%), Positives = 41/97 (42%), Gaps = 16/97 (16%)
Query: 736 ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASK 795
+TA+AW + + V G Q G + +W + GH G + + +SA
Sbjct: 2283 VTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGAL----------IWSSA-- 2330
Query: 796 DYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVD 832
H + +LS EK + W + + P +LH++
Sbjct: 2331 ----HTFFVLSADEKISEWQVKLRKGSAPGNLSLHLN 2363
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 53.1 bits (126), Expect = 2e-06
Identities = 61/294 (20%), Positives = 121/294 (41%), Gaps = 15/294 (5%)
Query: 726 RATLSGCHKG-ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIF 784
R G H G + + A+ + ++L+ G++DG + W+ ++ L GHTG V+ +
Sbjct: 13 RVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFS 72
Query: 785 AKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGS 844
G L SAS D T+ LW++ + K G + E ++ ++ ++
Sbjct: 73 PDGHLFASASCDCTVRLWDV--ARAKCLRVLKGHQRSVETVSFS---PDSRQLASGGWDK 127
Query: 845 KINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQH 904
++ W++++ + + +L D + L T S D V +W H
Sbjct: 128 RVMLWDVQSGQ-MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRM-VTPAVSH 185
Query: 905 MSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDA---VRFLVVSEDE 961
+ + G L +G + +I + LL +L V+ + S DE
Sbjct: 186 QALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
Query: 962 SLLA-AGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLD 1014
LA AG+ R V+++ ++ + L D+ T F + ++++G+ D
Sbjct: 246 LWLASAGYSRMVKVWDCNTGKCLETLKGVL---DVAHTCAFTPDGKILVSGAAD 296
Score = 43.5 bits (101), Expect = 0.001
Identities = 55/246 (22%), Positives = 102/246 (41%), Gaps = 18/246 (7%)
Query: 880 LLTVSRDGVVSLWSSATGKLQGKQ--HMSSIKEETPTCAVSVQKQGKLVTGFSNGSI--- 934
LLT S DG V W + +G+L + H +K C S G L S
Sbjct: 36 LLTGSEDGCVYGWETRSGQLLWRLGGHTGPVK----FCRFS--PDGHLFASASCDCTVRL 89
Query: 935 -SLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHE 993
+ +K R+L+ +V + S D LA+G G R+ L D + + + + + H
Sbjct: 90 WDVARAKCLRVLKGHQRSVETVSFSPDSRQLASG-GWDKRVMLWDVQS-GQMLRLLVGHR 147
Query: 994 DMVETAVFGTENNLIITGSLDALIQVWSLS--EQGTLLDILEGVGAPVSLLARGGALVAS 1051
D ++++ F N + TGS D+ + +W L LEG A +S L + + +
Sbjct: 148 DSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLA 207
Query: 1052 ASPQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEG 1111
+ + +W + + S + T + +++ + ++ G V +WD G
Sbjct: 208 SGSWDKTIHIWKPTTS--SLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTG 265
Query: 1112 EEQDSL 1117
+ ++L
Sbjct: 266 KCLETL 271
Score = 31.6 bits (70), Expect = 5.7
Identities = 18/82 (21%), Positives = 34/82 (41%), Gaps = 1/82 (1%)
Query: 1252 HRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDK 1311
HR + + S + +GS D+ + +WDL+ + + C C+S
Sbjct: 146 HRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG- 204
Query: 1312 YVYVGLKDRSILVWSVLDGTLL 1333
+ G D++I +W +LL
Sbjct: 205 LLASGSWDKTIHIWKPTTSSLL 226
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 53.1 bits (126), Expect = 2e-06
Identities = 54/213 (25%), Positives = 90/213 (42%), Gaps = 23/213 (10%)
Query: 747 LLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLS 806
LLV G+ DG VW + L GHTG V C+ + G A + S D T+ W++LS
Sbjct: 165 LLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILS 224
Query: 807 GQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSK-INAWNLETAEPVFHILGDAS 865
G++ E + + ++ +++VYS S + + W +T E V
Sbjct: 225 GEQLRVF--------REHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRR 276
Query: 866 DPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKEETPTCAVSVQKQG 923
+ A+ TL T S D + + +G+L+ + H I +Q G
Sbjct: 277 N---VSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIIN--------CIQVHG 325
Query: 924 K-LVTGFSNGSISLVSSKGDRLLEKLPDAVRFL 955
+ L T +G++ L +G R + P +R L
Sbjct: 326 QVLYTASHDGALRLWDVRGLRGAPRPPPPMRSL 358
Score = 45.4 bits (106), Expect = 4e-04
Identities = 77/375 (20%), Positives = 149/375 (39%), Gaps = 46/375 (12%)
Query: 722 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCV 781
GG + GI ++ + + L+ G++DG +W + +L GH V
Sbjct: 4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFC 63
Query: 782 KIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSA 841
++ + A + S D T+ W++L+GQ ++ G I N + +++ S+
Sbjct: 64 QL--EDEAAFTCSADCTIRRWDVLTGQ-CLQVYRG------HTSIVNRILVANNQLFSSS 114
Query: 842 SGSKINAWNLETAEPVFHILGDA--------SDPW-----MCMAVLASQATLLTVSRDGV 888
W+++ + G S PW C A+ L+T S DG
Sbjct: 115 YDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGT 174
Query: 889 VSLWSSATG----KLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSI---SLVSSKG 941
+W A+G L+G H ++ C V TG ++ +I ++S +
Sbjct: 175 AKVWQVASGCCHQTLRG--HTGAV-----LCLVLDTPGHTAFTGSTDATIRAWDILSGEQ 227
Query: 942 DRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADS-RGFRRFMAMDLEHEDMVETAV 1000
R+ + +V L + + + + R+V+ +LAD+ R F A H V
Sbjct: 228 LRVFREHRGSVICLEL-VNRLVYSGSADRTVKCWLADTGECVRTFTA----HRRNVSALK 282
Query: 1001 FGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFK 1060
+ + TGS DA + + ++ G L + G ++ + G ++ +AS + +
Sbjct: 283 Y--HAGTLFTGSGDACARAFD-AQSGELRRVFRGHTFIINCIQVHGQVLYTAS-HDGALR 338
Query: 1061 VWDLSDAHRSRVPAP 1075
+WD+ + P P
Sbjct: 339 LWDVRGLRGAPRPPP 353
Score = 32.7 bits (73), Expect = 2.6
Identities = 27/96 (28%), Positives = 42/96 (43%), Gaps = 6/96 (6%)
Query: 1252 HRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDK 1311
HR + + +S Q +++GSED LW + + SY Q +D+
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL-----EDE 68
Query: 1312 YVYVGLKDRSILVWSVLDGTLLTVQFVH-AVVNRII 1346
+ D +I W VL G L V H ++VNRI+
Sbjct: 69 AAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRIL 104
Score = 31.2 bits (69), Expect = 7.5
Identities = 34/152 (22%), Positives = 54/152 (35%), Gaps = 13/152 (8%)
Query: 1182 AYDNIVLVLDITSGDPCPVIDGPR-------YTFYTQLPETLSSVAILTDYRVVYSMTNG 1234
+YD V + G G R Y+ LP T + +V T+G
Sbjct: 114 SYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDG 173
Query: 1235 DLFLYECATSKAFP-LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSY 1293
+++ A+ L H V C+ + +GS DA + WD+ + E
Sbjct: 174 TAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSG----EQLR 229
Query: 1294 TSSYCRGVQCACFSKDDKYVYVGLKDRSILVW 1325
RG C ++ VY G DR++ W
Sbjct: 230 VFREHRG-SVICLELVNRLVYSGSADRTVKCW 260
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 52.0 bits (123), Expect = 4e-06
Identities = 68/292 (23%), Positives = 121/292 (41%), Gaps = 35/292 (11%)
Query: 747 LLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLS 806
LL G+ D + +WD+ ++ + + GHT V + L S S D TL LW+ S
Sbjct: 715 LLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATS 774
Query: 807 GQEKFTI----WDGGSKNPAEP-----QIWNLHVDEAHKVVYSASGSKINAWNLETAEPV 857
E+ +I + ++P E + + D A +V A+ +KI WN ++ V
Sbjct: 775 ANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV--AAKNKIFLWNTDSRSKV 832
Query: 858 FHILGDASDPWMCMAVLASQ-ATLLTVSRDGVVSLWSS----ATGKLQGKQHMSSIKEET 912
G S W+ + + ++ LT S D + LW + + KQ + + +E
Sbjct: 833 ADCRGHLS--WVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQEN 890
Query: 913 PTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAG--FGR 970
++V +L L++ + ++ V +S +A G G
Sbjct: 891 EVMVLAVDHIRRL---------QLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGA 941
Query: 971 SVRIFLADSRGFR-RFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWS 1021
+ L ++R F+ RF +H+ V F + +I+ S DA IQVW+
Sbjct: 942 IEILELVNNRIFQSRF-----QHKKTVWHIQFTADEKTLISSSDDAEIQVWN 988
Score = 40.4 bits (93), Expect = 0.012
Identities = 102/537 (18%), Positives = 199/537 (37%), Gaps = 64/537 (11%)
Query: 830 HVDEAHKVVYSASGSKI---------NAWNLETAEPVFHILGDASDPWMCMAVLASQATL 880
H D + +S G +I + ET E + I D +C A +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH-EDEVLCCAFSTDDRFI 672
Query: 881 LTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLV--TGFSNGSISLVS 938
T S D V +W+S TG+L H E C L+ TG S+ + L
Sbjct: 673 ATCSVDKKVKIWNSMTGELV---HTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
Query: 939 SKGDRLLEKL---PDAVRFLVVSEDESLLAA-GFGRSVRIFLADSRGFRR-------FMA 987
+ ++V S D+ LLA+ +++++ A S R+ F+
Sbjct: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789
Query: 988 MDLEHEDM---VETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVG--APVSLL 1042
++ EDM V+ + + I+ + + + +W+ + + D + V
Sbjct: 790 LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFS 848
Query: 1043 ARGGALVASASPQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNK 1102
G + + S+ Q+ ++W+ ++ A L + N V +
Sbjct: 849 PDGSSFLTSSDDQT--IRLWETKKVCKNS--AVMLKQEVDVVFQENEVMVLAV-----DH 899
Query: 1103 VTIWDLAEGEE-QDSLDTSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPP 1161
+ L G Q T +++ C ++ + + G +G + + L + + I
Sbjct: 900 IRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR--IFQSRF 957
Query: 1162 EARKAINCMSLSKCEDRLAIAYDNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAI 1221
+ +K + + + E L + D+ + + D C + G + ET+ +
Sbjct: 958 QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQ--------ETVKDFRL 1009
Query: 1222 LTDYRVVYSMTNGDLFLYECAT-SKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLW 1280
L + R++ +G + ++ T +K H+ V ++SH S S D
Sbjct: 1010 LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKT---- 1065
Query: 1281 DLQARKWKFEMSYTSSYCRG----VQCACFSKDDKYVYVGLKDRSILVWSVLDGTLL 1333
A+ W F++ RG V+C+ FS D + G + I +W+V +G LL
Sbjct: 1066 ---AKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1119
Score = 40.4 bits (93), Expect = 0.012
Identities = 36/167 (21%), Positives = 72/167 (43%), Gaps = 10/167 (5%)
Query: 734 KGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSA 793
K + + + +EK L+ + D + VW+ + I L GH V+ ++ L S
Sbjct: 961 KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRLL-SW 1018
Query: 794 SKDYTLHLWNLLSG-QEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLE 852
S D T+ +WN+++G +EK + G+ + +A K +++ W+ +
Sbjct: 1019 SFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS------HDATKFSSTSADKTAKIWSFD 1072
Query: 853 TAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKL 899
P+ + G + C A L T +G + +W+ + G+L
Sbjct: 1073 LLLPLHELRGH-NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1118
Score = 38.1 bits (87), Expect = 0.061
Identities = 102/498 (20%), Positives = 187/498 (37%), Gaps = 81/498 (16%)
Query: 894 SATGKLQGKQHMSSIKE----ETPTCAVSVQKQGKLVTGFSNGSISL--VSSKGDRLLEK 947
S G L G+Q +I + E T V Q + + NG + L ++ K L +
Sbjct: 549 SLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSR 608
Query: 948 L-----PDAVRFLVVSEDESLLAA-GFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVF 1001
L DAV SED +A+ G +++++F A++ + + + HED V F
Sbjct: 609 LVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETG--EKLLEIKA-HEDEVLCCAF 665
Query: 1002 GTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVS---LLARGGALVASASPQSSS 1058
T++ I T S+D +++W+ S G L+ + V+ L+ +
Sbjct: 666 STDDRFIATCSVDKKVKIWN-SMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 724
Query: 1059 FKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSL- 1117
K+WDL+ + S + + + +WD E+ S+
Sbjct: 725 LKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLL--ASCSADGTLKLWDATSANERKSIN 782
Query: 1118 -------------DTSSEIRC---------LEVAEQRKLLF------------TGLVSGV 1143
D ++C + VA + K+ G +S V
Sbjct: 783 VKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWV 842
Query: 1144 --VLVFPLNS----RQDVICIPPPEARKAINCMSLSKCEDRLAIAYDNIVLVLDITSGDP 1197
V+ P S D I E +K ++ ++ + +N V+VL +
Sbjct: 843 HGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRR 902
Query: 1198 CPVIDGPRYTFYTQLPETLSSVAILTDY--RVVYSMTNGDLFLYECATSKAFPLE-THRS 1254
+I+G R L E S L+ + + + NG + + E ++ F H+
Sbjct: 903 LQLING-RTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKK 961
Query: 1255 RVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVY 1314
V ++ + E+ ++S S+DA + +W+ Q K F + + KD +
Sbjct: 962 TVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETV----------KDFRL-- 1009
Query: 1315 VGLKDRSILVWSVLDGTL 1332
LK+ +L WS DGT+
Sbjct: 1010 --LKNSRLLSWS-FDGTV 1024
Score = 37.7 bits (86), Expect = 0.080
Identities = 31/128 (24%), Positives = 51/128 (39%), Gaps = 6/128 (4%)
Query: 732 CHKGITAMAWGVEEKLLVIGTQ--DGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTL 789
CH+G T ++ + + D +W + +H L GH G VRC TL
Sbjct: 1040 CHQG-TVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTL 1098
Query: 790 ANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIW--NLHVDEAHKVVYSASGSKIN 847
+ + + +WN+ +G+ + A W +L K++ SA G I
Sbjct: 1099 LATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA-GGYIK 1157
Query: 848 AWNLETAE 855
WN+ T E
Sbjct: 1158 WWNVVTGE 1165
Score = 32.0 bits (71), Expect = 4.4
Identities = 53/274 (19%), Positives = 97/274 (35%), Gaps = 50/274 (18%)
Query: 754 DGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTI 813
D + V+ E + + H EV C + S D + +WN ++G+ T
Sbjct: 636 DKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHT- 694
Query: 814 WDGGSKNPAEPQIWNLHVDEAHKVVYSASGSK---INAWNLETAEPVFHILGDASDPWMC 870
+D S+ Q+ H + + A+GS + W+L E + G + C
Sbjct: 695 YDEHSE-----QVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHC 749
Query: 871 MAVLASQATLLTVSRDGVVSLWSSATG----KLQGKQHMSSIKEETPTCAVSVQKQGKLV 926
L + S DG + LW + + + KQ ++++ V V K
Sbjct: 750 -RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIV----KCC 804
Query: 927 TGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFM 986
+ ++G+ +V++K L + R +AD RG
Sbjct: 805 SWSADGARIMVAAKNKIFL----------------------WNTDSRSKVADCRG----- 837
Query: 987 AMDLEHEDMVETAVFGTENNLIITGSLDALIQVW 1020
H V +F + + +T S D I++W
Sbjct: 838 -----HLSWVHGVMFSPDGSSFLTSSDDQTIRLW 866
Score = 30.8 bits (68), Expect = 9.8
Identities = 21/95 (22%), Positives = 41/95 (43%), Gaps = 11/95 (11%)
Query: 733 HKG-ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHM--------LTGHTGEVRCVKI 783
H G + A+ V+ LL G +G + +W++ ++H+ H G V +
Sbjct: 1083 HNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCF 1142
Query: 784 FAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGS 818
G + SA + WN+++G+ T + G+
Sbjct: 1143 SPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGT 1175
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 52.0 bits (123), Expect = 4e-06
Identities = 68/292 (23%), Positives = 121/292 (41%), Gaps = 35/292 (11%)
Query: 747 LLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLS 806
LL G+ D + +WD+ ++ + + GHT V + L S S D TL LW+ S
Sbjct: 704 LLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATS 763
Query: 807 GQEKFTI----WDGGSKNPAEP-----QIWNLHVDEAHKVVYSASGSKINAWNLETAEPV 857
E+ +I + ++P E + + D A +V A+ +KI WN ++ V
Sbjct: 764 ANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV--AAKNKIFLWNTDSRSKV 821
Query: 858 FHILGDASDPWMCMAVLASQ-ATLLTVSRDGVVSLWSS----ATGKLQGKQHMSSIKEET 912
G S W+ + + ++ LT S D + LW + + KQ + + +E
Sbjct: 822 ADCRGHLS--WVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQEN 879
Query: 913 PTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAG--FGR 970
++V +L L++ + ++ V +S +A G G
Sbjct: 880 EVMVLAVDHIRRL---------QLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGA 930
Query: 971 SVRIFLADSRGFR-RFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWS 1021
+ L ++R F+ RF +H+ V F + +I+ S DA IQVW+
Sbjct: 931 IEILELVNNRIFQSRF-----QHKKTVWHIQFTADEKTLISSSDDAEIQVWN 977
Score = 40.4 bits (93), Expect = 0.012
Identities = 102/537 (18%), Positives = 199/537 (37%), Gaps = 64/537 (11%)
Query: 830 HVDEAHKVVYSASGSKI---------NAWNLETAEPVFHILGDASDPWMCMAVLASQATL 880
H D + +S G +I + ET E + I D +C A +
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH-EDEVLCCAFSTDDRFI 661
Query: 881 LTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLV--TGFSNGSISLVS 938
T S D V +W+S TG+L H E C L+ TG S+ + L
Sbjct: 662 ATCSVDKKVKIWNSMTGELV---HTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
Query: 939 SKGDRLLEKL---PDAVRFLVVSEDESLLAA-GFGRSVRIFLADSRGFRR-------FMA 987
+ ++V S D+ LLA+ +++++ A S R+ F+
Sbjct: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
Query: 988 MDLEHEDM---VETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVG--APVSLL 1042
++ EDM V+ + + I+ + + + +W+ + + D + V
Sbjct: 779 LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFS 837
Query: 1043 ARGGALVASASPQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNK 1102
G + + S+ Q+ ++W+ ++ A L + N V +
Sbjct: 838 PDGSSFLTSSDDQT--IRLWETKKVCKNS--AVMLKQEVDVVFQENEVMVLAV-----DH 888
Query: 1103 VTIWDLAEGEE-QDSLDTSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPP 1161
+ L G Q T +++ C ++ + + G +G + + L + + I
Sbjct: 889 IRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR--IFQSRF 946
Query: 1162 EARKAINCMSLSKCEDRLAIAYDNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAI 1221
+ +K + + + E L + D+ + + D C + G + ET+ +
Sbjct: 947 QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQ--------ETVKDFRL 998
Query: 1222 LTDYRVVYSMTNGDLFLYECAT-SKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLW 1280
L + R++ +G + ++ T +K H+ V ++SH S S D
Sbjct: 999 LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKT---- 1054
Query: 1281 DLQARKWKFEMSYTSSYCRG----VQCACFSKDDKYVYVGLKDRSILVWSVLDGTLL 1333
A+ W F++ RG V+C+ FS D + G + I +W+V +G LL
Sbjct: 1055 ---AKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1108
Score = 40.4 bits (93), Expect = 0.012
Identities = 36/167 (21%), Positives = 72/167 (43%), Gaps = 10/167 (5%)
Query: 734 KGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSA 793
K + + + +EK L+ + D + VW+ + I L GH V+ ++ L S
Sbjct: 950 KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRLL-SW 1007
Query: 794 SKDYTLHLWNLLSG-QEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLE 852
S D T+ +WN+++G +EK + G+ + +A K +++ W+ +
Sbjct: 1008 SFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS------HDATKFSSTSADKTAKIWSFD 1061
Query: 853 TAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKL 899
P+ + G + C A L T +G + +W+ + G+L
Sbjct: 1062 LLLPLHELRGH-NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1107
Score = 38.1 bits (87), Expect = 0.061
Identities = 102/498 (20%), Positives = 187/498 (37%), Gaps = 81/498 (16%)
Query: 894 SATGKLQGKQHMSSIKE----ETPTCAVSVQKQGKLVTGFSNGSISL--VSSKGDRLLEK 947
S G L G+Q +I + E T V Q + + NG + L ++ K L +
Sbjct: 538 SLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSR 597
Query: 948 L-----PDAVRFLVVSEDESLLAA-GFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVF 1001
L DAV SED +A+ G +++++F A++ + + + HED V F
Sbjct: 598 LVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETG--EKLLEIKA-HEDEVLCCAF 654
Query: 1002 GTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVS---LLARGGALVASASPQSSS 1058
T++ I T S+D +++W+ S G L+ + V+ L+ +
Sbjct: 655 STDDRFIATCSVDKKVKIWN-SMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 713
Query: 1059 FKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSL- 1117
K+WDL+ + S + + + +WD E+ S+
Sbjct: 714 LKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLL--ASCSADGTLKLWDATSANERKSIN 771
Query: 1118 -------------DTSSEIRC---------LEVAEQRKLLF------------TGLVSGV 1143
D ++C + VA + K+ G +S V
Sbjct: 772 VKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWV 831
Query: 1144 --VLVFPLNS----RQDVICIPPPEARKAINCMSLSKCEDRLAIAYDNIVLVLDITSGDP 1197
V+ P S D I E +K ++ ++ + +N V+VL +
Sbjct: 832 HGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRR 891
Query: 1198 CPVIDGPRYTFYTQLPETLSSVAILTDY--RVVYSMTNGDLFLYECATSKAFPLE-THRS 1254
+I+G R L E S L+ + + + NG + + E ++ F H+
Sbjct: 892 LQLING-RTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKK 950
Query: 1255 RVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVY 1314
V ++ + E+ ++S S+DA + +W+ Q K F + + KD +
Sbjct: 951 TVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETV----------KDFRL-- 998
Query: 1315 VGLKDRSILVWSVLDGTL 1332
LK+ +L WS DGT+
Sbjct: 999 --LKNSRLLSWS-FDGTV 1013
Score = 37.7 bits (86), Expect = 0.080
Identities = 31/128 (24%), Positives = 51/128 (39%), Gaps = 6/128 (4%)
Query: 732 CHKGITAMAWGVEEKLLVIGTQ--DGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTL 789
CH+G T ++ + + D +W + +H L GH G VRC TL
Sbjct: 1029 CHQG-TVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTL 1087
Query: 790 ANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIW--NLHVDEAHKVVYSASGSKIN 847
+ + + +WN+ +G+ + A W +L K++ SA G I
Sbjct: 1088 LATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA-GGYIK 1146
Query: 848 AWNLETAE 855
WN+ T E
Sbjct: 1147 WWNVVTGE 1154
Score = 32.0 bits (71), Expect = 4.4
Identities = 53/274 (19%), Positives = 97/274 (35%), Gaps = 50/274 (18%)
Query: 754 DGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTI 813
D + V+ E + + H EV C + S D + +WN ++G+ T
Sbjct: 625 DKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHT- 683
Query: 814 WDGGSKNPAEPQIWNLHVDEAHKVVYSASGSK---INAWNLETAEPVFHILGDASDPWMC 870
+D S+ Q+ H + + A+GS + W+L E + G + C
Sbjct: 684 YDEHSE-----QVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHC 738
Query: 871 MAVLASQATLLTVSRDGVVSLWSSATG----KLQGKQHMSSIKEETPTCAVSVQKQGKLV 926
L + S DG + LW + + + KQ ++++ V V K
Sbjct: 739 -RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIV----KCC 793
Query: 927 TGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFM 986
+ ++G+ +V++K L + R +AD RG
Sbjct: 794 SWSADGARIMVAAKNKIFL----------------------WNTDSRSKVADCRG----- 826
Query: 987 AMDLEHEDMVETAVFGTENNLIITGSLDALIQVW 1020
H V +F + + +T S D I++W
Sbjct: 827 -----HLSWVHGVMFSPDGSSFLTSSDDQTIRLW 855
Score = 30.8 bits (68), Expect = 9.8
Identities = 21/95 (22%), Positives = 41/95 (43%), Gaps = 11/95 (11%)
Query: 733 HKG-ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHM--------LTGHTGEVRCVKI 783
H G + A+ V+ LL G +G + +W++ ++H+ H G V +
Sbjct: 1072 HNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCF 1131
Query: 784 FAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGS 818
G + SA + WN+++G+ T + G+
Sbjct: 1132 SPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGT 1164
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 51.6 bits (122), Expect = 5e-06
Identities = 35/118 (29%), Positives = 58/118 (49%), Gaps = 14/118 (11%)
Query: 727 ATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAK 786
++LSG I ++A ++V G+ + ++ VWD + L GHT V+ + +
Sbjct: 162 SSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRD 221
Query: 787 GTLANSASKDYTLHLWNLLSGQEK----FTIWDGGSKNPAEPQIWNLHVDEAHKVVYS 840
GT S S D T+ LW+L GQ++ + + D G +W L V++A VYS
Sbjct: 222 GTQCLSGSSDGTIRLWSL--GQQRCIATYRVHDEG--------VWALQVNDAFTHVYS 269
Score = 35.0 bits (79), Expect = 0.52
Identities = 46/216 (21%), Positives = 94/216 (43%), Gaps = 28/216 (12%)
Query: 829 LHVDEAHKVVYSAS-GSKINAW--NLETAEPVFHILGDASDPWMCMAVLASQA-TLLTVS 884
L +D A +++A S I W N +P + +D W+ VL TL++ S
Sbjct: 36 LQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTD-WVNDIVLCCNGKTLISAS 94
Query: 885 RDGVVSLWSSATGKLQG-----KQHMSSI---KEETPTCAVSVQKQGKL-------VTGF 929
D V +W++ G K ++ ++ K++ + + +Q L
Sbjct: 95 SDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTA 154
Query: 930 SNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMD 989
SN +++ S G++ D++ L +++ +++ +G V + + D R + M +
Sbjct: 155 SNNTVTTSSLSGNK------DSIYSLAMNQLGTIIVSGSTEKV-LRVWDPRTCAKLMKLK 207
Query: 990 LEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQ 1025
H D V+ + + ++GS D I++WSL +Q
Sbjct: 208 -GHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQ 242
Score = 34.3 bits (77), Expect = 0.88
Identities = 46/246 (18%), Positives = 97/246 (39%), Gaps = 26/246 (10%)
Query: 880 LLTVSRDGVVSLWSSATGK----LQGKQHMSSIKEETPTCAVSVQKQGK-LVTGFSNGSI 934
L T RD ++ +WS K + +H + + C GK L++ S+ ++
Sbjct: 45 LFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCC-----NGKTLISASSDTTV 99
Query: 935 SLVSSKGDRLLEKL---PDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLE 991
+ ++ + L D V+ L ++D+ L+A+ G +IFL D A +
Sbjct: 100 KVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASA-GLDRQIFLWDVNTLTALTASNNT 158
Query: 992 --------HEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLA 1043
++D + + +I++GS + +++VW L+ + +LL
Sbjct: 159 VTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLL 218
Query: 1044 RGGALVASASPQSSSFKVWDLSDAHRSRVPAPF-LDRTGLTAVSHNGSYVYFPKIGDKNK 1102
+ + ++W L + R A + + G+ A+ N ++ + G K
Sbjct: 219 NRDGTQCLSGSSDGTIRLWSLG---QQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRK 275
Query: 1103 VTIWDL 1108
+ DL
Sbjct: 276 IYCTDL 281
>gi|48928050 F-box and WD repeat domain containing 11 isoform C [Homo
sapiens]
Length = 542
Score = 51.6 bits (122), Expect = 5e-06
Identities = 76/356 (21%), Positives = 135/356 (37%), Gaps = 103/356 (28%)
Query: 734 KGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSA 793
KG+ + + +++ ++ G +D + +WD + +LTGHTG V C++ + + +
Sbjct: 241 KGVYCLQY--DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTG 296
Query: 794 SKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLET 853
S D T+ +W++ +G+ T+ +H +EA
Sbjct: 297 SSDSTVRVWDVNTGEVLNTL---------------IHHNEA------------------- 322
Query: 854 AEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETP 913
V H+ S ++T S+D +++W M+S + T
Sbjct: 323 ---VLHL-------------RFSNGLMVTCSKDRSIAVWD-----------MASATDITL 355
Query: 914 TCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVR 973
+ + V F + I VS+ GDR ++ + S
Sbjct: 356 RRVLVGHRAAVNVVDFDDKYI--VSASGDRTIKV--------------------WSTSTC 393
Query: 974 IFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILE 1033
F+ G +R +A L++ D L+++GS D I++W + E G L +LE
Sbjct: 394 EFVRTLNGHKRGIAC-LQYRD-----------RLVVSGSSDNTIRLWDI-ECGACLRVLE 440
Query: 1034 GVGAPVSLLARGGALVASASPQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNG 1089
G V + + S + KVWDL A R PA L T V H+G
Sbjct: 441 GHEELVRCIRFDNKRIVSGA-YDGKIKVWDLQAALDPRAPASTLCLR--TLVEHSG 493
Score = 42.0 bits (97), Expect = 0.004
Identities = 23/77 (29%), Positives = 43/77 (55%), Gaps = 4/77 (5%)
Query: 728 TLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKG 787
TL+G +GI + + ++L+V G+ D + +WD+E + +L GH VRC++ K
Sbjct: 398 TLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR 455
Query: 788 TLANSASKDYTLHLWNL 804
+ S + D + +W+L
Sbjct: 456 IV--SGAYDGKIKVWDL 470
Score = 38.1 bits (87), Expect = 0.061
Identities = 23/79 (29%), Positives = 38/79 (48%), Gaps = 7/79 (8%)
Query: 1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSK 1308
L H+ +AC++ ++++LVVSGS D + LWD++ + R C
Sbjct: 399 LNGHKRGIACLQ--YRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVR-----CIRF 451
Query: 1309 DDKYVYVGLKDRSILVWSV 1327
D+K + G D I VW +
Sbjct: 452 DNKRIVSGAYDGKIKVWDL 470
Score = 37.4 bits (85), Expect = 0.10
Identities = 31/130 (23%), Positives = 55/130 (42%), Gaps = 11/130 (8%)
Query: 725 LRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIF 784
LR L G + + + ++K +V + D + VW + L GH + C++
Sbjct: 355 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY- 411
Query: 785 AKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGS 844
+ L S S D T+ LW++ G + +G E + + D ++V A
Sbjct: 412 -RDRLVVSGSSDNTIRLWDIECG-ACLRVLEG-----HEELVRCIRFDN-KRIVSGAYDG 463
Query: 845 KINAWNLETA 854
KI W+L+ A
Sbjct: 464 KIKVWDLQAA 473
Score = 34.3 bits (77), Expect = 0.88
Identities = 24/122 (19%), Positives = 57/122 (46%), Gaps = 20/122 (16%)
Query: 1224 DYRVVYSMTNGDLFLYECATSKAFPLET-HRSRVACVEVSHKEQLVVSGSEDALLCLWDL 1282
D +++ + + + +++ + + + T H V C++ + E+++V+GS D+ + +WD+
Sbjct: 250 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSSDSTVRVWDV 307
Query: 1283 QARKWKFEMSYTSS------YCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQ 1336
+ + + + + G+ C KDRSI VW + T +T++
Sbjct: 308 NTGEVLNTLIHHNEAVLHLRFSNGLMVTC-----------SKDRSIAVWDMASATDITLR 356
Query: 1337 FV 1338
V
Sbjct: 357 RV 358
Score = 33.1 bits (74), Expect = 2.0
Identities = 28/130 (21%), Positives = 58/130 (44%), Gaps = 6/130 (4%)
Query: 1004 ENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKVWD 1063
+ +I+TGS D+ ++VW ++ L ++ A + L G +V + + S VWD
Sbjct: 289 DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCS--KDRSIAVWD 346
Query: 1064 LSDAHRSRVPAPFL-DRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDTSSE 1122
++ A + + R + V + Y+ GD+ + +W + E +L+
Sbjct: 347 MASATDITLRRVLVGHRAAVNVVDFDDKYIVSAS-GDRT-IKVWSTSTCEFVRTLNGHKR 404
Query: 1123 -IRCLEVAEQ 1131
I CL+ ++
Sbjct: 405 GIACLQYRDR 414
Score = 32.7 bits (73), Expect = 2.6
Identities = 26/95 (27%), Positives = 42/95 (44%), Gaps = 7/95 (7%)
Query: 1252 HRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDK 1311
HR+ V V+ K +VS S D + +W ++ + + + RG+ AC D+
Sbjct: 362 HRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEF---VRTLNGHKRGI--ACLQYRDR 414
Query: 1312 YVYVGLKDRSILVWSVLDGTLLTVQFVHAVVNRII 1346
V G D +I +W + G L V H + R I
Sbjct: 415 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCI 449
Score = 31.6 bits (70), Expect = 5.7
Identities = 15/36 (41%), Positives = 21/36 (58%), Gaps = 2/36 (5%)
Query: 1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQA 1284
LE H V C+ +K +VSG+ D + +WDLQA
Sbjct: 439 LEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLQA 472
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 51.6 bits (122), Expect = 5e-06
Identities = 41/195 (21%), Positives = 86/195 (44%), Gaps = 13/195 (6%)
Query: 747 LLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLS 806
+LV ++D +WD+ + +H L+GHT V V+ A + S D T+ LW+L++
Sbjct: 302 VLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVA 361
Query: 807 GQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASD 866
G+ + T+ + + + + + H S S I W + ++ G +
Sbjct: 362 GKTRVTLTN------HKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSG--HN 413
Query: 867 PWMCMAVLASQATLLTVSRDGVVSLWSSATG----KLQGKQHMSSIKEETPTCAVSV-QK 921
+ + S L++ + +G + LW TG ++ S+ E+ A + Q
Sbjct: 414 AIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQS 473
Query: 922 QGKLVTGFSNGSISL 936
+ +L+T ++ +I +
Sbjct: 474 ESRLLTAEADKTIKV 488
Score = 44.7 bits (104), Expect = 7e-04
Identities = 60/293 (20%), Positives = 120/293 (40%), Gaps = 20/293 (6%)
Query: 770 MLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNL 829
+++GH G VRC+ + + S D T+ +W+L SG+ K ++ S + +
Sbjct: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHIS------TVRGV 252
Query: 830 HVDEAHKVVYSASGSK-INAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGV 888
V ++S K + W+LE + + H G S + + + + L+T SRD
Sbjct: 253 IVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVY-GLDLHPTIDVLVTCSRDST 311
Query: 889 VSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSI---SLVSSKGDRLL 945
+W T + H S + +++TG + +I LV+ K L
Sbjct: 312 ARIWDVRT---KASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTL 368
Query: 946 EKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTEN 1005
+VR +V+ A+G +++ + F + ++ H ++ T ++
Sbjct: 369 TNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLS---GHNAIINTLTVNSD- 424
Query: 1006 NLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSS 1058
++++G+ + + +W G + P SL + G + A A QS S
Sbjct: 425 GVLVSGADNGTMHLWDW-RTGYNFQRVHAAVQPGSLDSESG-IFACAFDQSES 475
Score = 40.4 bits (93), Expect = 0.012
Identities = 39/179 (21%), Positives = 70/179 (39%), Gaps = 8/179 (4%)
Query: 721 PGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRC 780
P L +SG + +A + V G+ D + +WD+ + LTGH VR
Sbjct: 192 PPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRG 251
Query: 781 VKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYS 840
V + + S +D + W+ L + + G ++ L + V+ +
Sbjct: 252 VIVSTRSPYLFSCGEDKQVKCWD-LEYNKVIRHYHGHLS-----AVYGLDLHPTIDVLVT 305
Query: 841 AS-GSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGK 898
S S W++ T V H L ++ + A++ ++T S D + LW GK
Sbjct: 306 CSRDSTARIWDVRTKASV-HTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGK 363
Score = 37.0 bits (84), Expect = 0.14
Identities = 22/76 (28%), Positives = 35/76 (46%), Gaps = 3/76 (3%)
Query: 1252 HRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDK 1311
H V C+ V Q V+GS D + +WDL + K K ++ S RGV S
Sbjct: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGV---IVSTRSP 259
Query: 1312 YVYVGLKDRSILVWSV 1327
Y++ +D+ + W +
Sbjct: 260 YLFSCGEDKQVKCWDL 275
Score = 36.6 bits (83), Expect = 0.18
Identities = 34/135 (25%), Positives = 53/135 (39%), Gaps = 12/135 (8%)
Query: 1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSK 1308
L H + VA V E +++GS D + LWDL A K + ++ R V
Sbjct: 326 LSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAV----VLH 381
Query: 1309 DDKYVYVGLKDRSILVWSVLDGTLLTVQFVH-AVVNRIIPTTSGFIAP-----TRHGYLI 1362
Y + +I W DG+ + H A++N + + G + T H +
Sbjct: 382 PRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDW 441
Query: 1363 RE--NFQCLSAKASP 1375
R NFQ + A P
Sbjct: 442 RTGYNFQRVHAAVQP 456
>gi|48928048 F-box and WD repeat domain containing 11 isoform A [Homo
sapiens]
Length = 508
Score = 51.6 bits (122), Expect = 5e-06
Identities = 76/356 (21%), Positives = 135/356 (37%), Gaps = 103/356 (28%)
Query: 734 KGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSA 793
KG+ + + +++ ++ G +D + +WD + +LTGHTG V C++ + + +
Sbjct: 207 KGVYCLQY--DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTG 262
Query: 794 SKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLET 853
S D T+ +W++ +G+ T+ +H +EA
Sbjct: 263 SSDSTVRVWDVNTGEVLNTL---------------IHHNEA------------------- 288
Query: 854 AEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETP 913
V H+ S ++T S+D +++W M+S + T
Sbjct: 289 ---VLHL-------------RFSNGLMVTCSKDRSIAVWD-----------MASATDITL 321
Query: 914 TCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVR 973
+ + V F + I VS+ GDR ++ + S
Sbjct: 322 RRVLVGHRAAVNVVDFDDKYI--VSASGDRTIKV--------------------WSTSTC 359
Query: 974 IFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILE 1033
F+ G +R +A L++ D L+++GS D I++W + E G L +LE
Sbjct: 360 EFVRTLNGHKRGIAC-LQYRD-----------RLVVSGSSDNTIRLWDI-ECGACLRVLE 406
Query: 1034 GVGAPVSLLARGGALVASASPQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNG 1089
G V + + S + KVWDL A R PA L T V H+G
Sbjct: 407 GHEELVRCIRFDNKRIVSGA-YDGKIKVWDLQAALDPRAPASTLCLR--TLVEHSG 459
Score = 42.0 bits (97), Expect = 0.004
Identities = 23/77 (29%), Positives = 43/77 (55%), Gaps = 4/77 (5%)
Query: 728 TLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKG 787
TL+G +GI + + ++L+V G+ D + +WD+E + +L GH VRC++ K
Sbjct: 364 TLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR 421
Query: 788 TLANSASKDYTLHLWNL 804
+ S + D + +W+L
Sbjct: 422 IV--SGAYDGKIKVWDL 436
Score = 38.1 bits (87), Expect = 0.061
Identities = 23/79 (29%), Positives = 38/79 (48%), Gaps = 7/79 (8%)
Query: 1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSK 1308
L H+ +AC++ ++++LVVSGS D + LWD++ + R C
Sbjct: 365 LNGHKRGIACLQ--YRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVR-----CIRF 417
Query: 1309 DDKYVYVGLKDRSILVWSV 1327
D+K + G D I VW +
Sbjct: 418 DNKRIVSGAYDGKIKVWDL 436
Score = 37.4 bits (85), Expect = 0.10
Identities = 31/130 (23%), Positives = 55/130 (42%), Gaps = 11/130 (8%)
Query: 725 LRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIF 784
LR L G + + + ++K +V + D + VW + L GH + C++
Sbjct: 321 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY- 377
Query: 785 AKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGS 844
+ L S S D T+ LW++ G + +G E + + D ++V A
Sbjct: 378 -RDRLVVSGSSDNTIRLWDIECG-ACLRVLEG-----HEELVRCIRFDN-KRIVSGAYDG 429
Query: 845 KINAWNLETA 854
KI W+L+ A
Sbjct: 430 KIKVWDLQAA 439
Score = 34.3 bits (77), Expect = 0.88
Identities = 24/122 (19%), Positives = 57/122 (46%), Gaps = 20/122 (16%)
Query: 1224 DYRVVYSMTNGDLFLYECATSKAFPLET-HRSRVACVEVSHKEQLVVSGSEDALLCLWDL 1282
D +++ + + + +++ + + + T H V C++ + E+++V+GS D+ + +WD+
Sbjct: 216 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSSDSTVRVWDV 273
Query: 1283 QARKWKFEMSYTSS------YCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQ 1336
+ + + + + G+ C KDRSI VW + T +T++
Sbjct: 274 NTGEVLNTLIHHNEAVLHLRFSNGLMVTC-----------SKDRSIAVWDMASATDITLR 322
Query: 1337 FV 1338
V
Sbjct: 323 RV 324
Score = 33.1 bits (74), Expect = 2.0
Identities = 28/130 (21%), Positives = 58/130 (44%), Gaps = 6/130 (4%)
Query: 1004 ENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKVWD 1063
+ +I+TGS D+ ++VW ++ L ++ A + L G +V + + S VWD
Sbjct: 255 DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCS--KDRSIAVWD 312
Query: 1064 LSDAHRSRVPAPFL-DRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDTSSE 1122
++ A + + R + V + Y+ GD+ + +W + E +L+
Sbjct: 313 MASATDITLRRVLVGHRAAVNVVDFDDKYIVSAS-GDRT-IKVWSTSTCEFVRTLNGHKR 370
Query: 1123 -IRCLEVAEQ 1131
I CL+ ++
Sbjct: 371 GIACLQYRDR 380
Score = 32.7 bits (73), Expect = 2.6
Identities = 26/95 (27%), Positives = 42/95 (44%), Gaps = 7/95 (7%)
Query: 1252 HRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDK 1311
HR+ V V+ K +VS S D + +W ++ + + + RG+ AC D+
Sbjct: 328 HRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEF---VRTLNGHKRGI--ACLQYRDR 380
Query: 1312 YVYVGLKDRSILVWSVLDGTLLTVQFVHAVVNRII 1346
V G D +I +W + G L V H + R I
Sbjct: 381 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCI 415
Score = 31.6 bits (70), Expect = 5.7
Identities = 15/36 (41%), Positives = 21/36 (58%), Gaps = 2/36 (5%)
Query: 1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQA 1284
LE H V C+ +K +VSG+ D + +WDLQA
Sbjct: 405 LEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLQA 438
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,678,548
Number of Sequences: 37866
Number of extensions: 2577906
Number of successful extensions: 8241
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 143
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 6255
Number of HSP's gapped (non-prelim): 1676
length of query: 1429
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1314
effective length of database: 13,892,928
effective search space: 18255307392
effective search space used: 18255307392
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.