Guide to the Human Genome
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Search of human proteins with 112734870

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
         (1094 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|112734870 hypothetical protein LOC57648 [Homo sapiens]            2209   0.0  
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   164   6e-40
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...   142   1e-33
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   140   7e-33
gi|163965366 nascent polypeptide-associated complex alpha subuni...   140   9e-33
gi|47132519 Ras association and pleckstrin homology domains 1 is...   129   1e-29
gi|160707881 formin 2 [Homo sapiens]                                  126   1e-28
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]    122   2e-27
gi|221139926 NHS-like 1 [Homo sapiens]                                120   7e-27
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...   119   1e-26
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...   119   1e-26
gi|110349719 titin isoform N2-A [Homo sapiens]                        114   5e-25
gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapi...   113   9e-25
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...   112   2e-24
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]         110   9e-24
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]         110   9e-24
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                  109   1e-23
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                   109   1e-23
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]         108   2e-23
gi|150170670 piccolo isoform 2 [Homo sapiens]                         108   3e-23
gi|150378539 piccolo isoform 1 [Homo sapiens]                         108   3e-23
gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]        106   1e-22
gi|116284392 mucin 2 precursor [Homo sapiens]                         105   2e-22
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                  104   5e-22
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                  104   5e-22
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre...   101   4e-21
gi|55750053 atrophin-1 [Homo sapiens]                                 100   8e-21
gi|55750041 atrophin-1 [Homo sapiens]                                 100   8e-21
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...   100   8e-21
gi|153792074 proline rich 12 [Homo sapiens]                           100   8e-21

>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 2209 bits (5723), Expect = 0.0
 Identities = 1094/1094 (100%), Positives = 1094/1094 (100%)

Query: 1    MAARAPPAAPAAEEPGNPGGPPRRKKSRSGASGLRRAFSWLRGKRRKKKAAGAEGAEPAA 60
            MAARAPPAAPAAEEPGNPGGPPRRKKSRSGASGLRRAFSWLRGKRRKKKAAGAEGAEPAA
Sbjct: 1    MAARAPPAAPAAEEPGNPGGPPRRKKSRSGASGLRRAFSWLRGKRRKKKAAGAEGAEPAA 60

Query: 61   PRAKKAEDKAKRAKGKGRGSAKAENDKHLSVGPGQGPGSAVDEHQDNVFFPSGRPPHLEE 120
            PRAKKAEDKAKRAKGKGRGSAKAENDKHLSVGPGQGPGSAVDEHQDNVFFPSGRPPHLEE
Sbjct: 61   PRAKKAEDKAKRAKGKGRGSAKAENDKHLSVGPGQGPGSAVDEHQDNVFFPSGRPPHLEE 120

Query: 121  LHTQAQEGLRSLQHQEKQKLNKGGWDHGDTQSIQSSRTGPDEDNISFCSQTTSYVAESST 180
            LHTQAQEGLRSLQHQEKQKLNKGGWDHGDTQSIQSSRTGPDEDNISFCSQTTSYVAESST
Sbjct: 121  LHTQAQEGLRSLQHQEKQKLNKGGWDHGDTQSIQSSRTGPDEDNISFCSQTTSYVAESST 180

Query: 181  AEDALSIRSEMIQRKGSTFRPHDSFPKSGKSGRRRRERRSTVLGLPQHVQKELGLRNERE 240
            AEDALSIRSEMIQRKGSTFRPHDSFPKSGKSGRRRRERRSTVLGLPQHVQKELGLRNERE
Sbjct: 181  AEDALSIRSEMIQRKGSTFRPHDSFPKSGKSGRRRRERRSTVLGLPQHVQKELGLRNERE 240

Query: 241  APGTPRAPGARDAVRIPTVDGRPRGTSGMGARVSLQALEAEAEAGAETEAMLQRHIDRVY 300
            APGTPRAPGARDAVRIPTVDGRPRGTSGMGARVSLQALEAEAEAGAETEAMLQRHIDRVY
Sbjct: 241  APGTPRAPGARDAVRIPTVDGRPRGTSGMGARVSLQALEAEAEAGAETEAMLQRHIDRVY 300

Query: 301  RDDTFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVL 360
            RDDTFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVL
Sbjct: 301  RDDTFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVL 360

Query: 361  PPTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQ 420
            PPTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQ
Sbjct: 361  PPTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQ 420

Query: 421  SSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRS 480
            SSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRS
Sbjct: 421  SSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRS 480

Query: 481  SGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTG 540
            SGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTG
Sbjct: 481  SGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTG 540

Query: 541  GSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAG 600
            GSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAG
Sbjct: 541  GSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAG 600

Query: 601  PPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVI 660
            PPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVI
Sbjct: 601  PPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVI 660

Query: 661  PPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQES 720
            PPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQES
Sbjct: 661  PPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQES 720

Query: 721  PVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQ 780
            PVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQ
Sbjct: 721  PVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQ 780

Query: 781  DLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPP 840
            DLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPP
Sbjct: 781  DLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPP 840

Query: 841  APAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPT 900
            APAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPT
Sbjct: 841  APAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPT 900

Query: 901  PALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEP 960
            PALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEP
Sbjct: 901  PALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEP 960

Query: 961  RPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPK 1020
            RPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPK
Sbjct: 961  RPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPK 1020

Query: 1021 APPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVLQLVGPEE 1080
            APPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVLQLVGPEE
Sbjct: 1021 APPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVLQLVGPEE 1080

Query: 1081 KMGLPGSDSQKELA 1094
            KMGLPGSDSQKELA
Sbjct: 1081 KMGLPGSDSQKELA 1094


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score =  164 bits (414), Expect = 6e-40
 Identities = 285/1101 (25%), Positives = 400/1101 (36%), Gaps = 170/1101 (15%)

Query: 2    AARAPPA-APAAEEPGNPGGPPRRKKSRSGASGLRRAFSWLRGKRRKKKAAGAEGAE--P 58
            AAR P A AP    P  PG P         A  +  A   +  K   ++A G  GA    
Sbjct: 13   AARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPE 72

Query: 59   AAPRA-------KKAEDKAKRAKGKGRGSAKAENDKHLSVGPGQGPGSAVDEHQDNVFFP 111
            +APRA         + + A R    GRG  +A   K+ S GP   PG A    +      
Sbjct: 73   SAPRAGPTRSAGTSSRNPASRPPASGRGE-RAPPAKNTSPGPVSSPGRASGTTRPGPLGQ 131

Query: 112  SGRPPHLEELHTQAQEGLRSLQHQEKQKLNKGGWDHGDTQSIQSSRTGPDEDNISFCSQT 171
             G     EE   +     ++ +  ++  L+ G     DT     S   P   + +   ++
Sbjct: 132  KGLRISAEETVARG----KATEAPKRSALSAGA--RRDT-----SGPTPGTPSPAMARRS 180

Query: 172  TSYVAESSTAEDALSIR----SEMIQRKGSTFRPHDSFPKSGKSGRRRRERRSTVLGLPQ 227
             +   E      A S R    +E  ++  S+   H +   S  +    R R S   GL +
Sbjct: 181  RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAA----RRRPSAGGGLQR 236

Query: 228  HVQKELG---------LRNEREAPGTPRAPG--------ARDAVRIPTVDGRPRGTSGMG 270
               + L           R+   A GTPRAP            A+R P V    +  +   
Sbjct: 237  PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296

Query: 271  ARVSLQALEAEAEAGAETEAMLQRHIDRVYRDDTFVGRSTGTR--APPLTRPMSLAVPGL 328
              +S   L   + +G +           V   D        T   +PPL  P+ LA P  
Sbjct: 297  GPLSSSPLATPSPSGTKARP--------VPPPDNAATPLPATLPPSPPLATPLPLAPPS- 347

Query: 329  TGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCSL----RTLSRCSLHS 384
                 P+ P S     SP AT  S+  P    PP     +L          +L+  SL +
Sbjct: 348  -----PSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQA 402

Query: 385  A-SPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPE 443
              SP ++ SL   +S+ SP  ++ H   S  T S  Q+  ++ S     S+   S   P 
Sbjct: 403  PPSPLALSSLQATTSLGSPTLQATH---SFLTMSPRQTQASLTSPSRPASTPPDSP--PL 457

Query: 444  SSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRR 503
             +  S    PP Q      SP+    +       +++   L+  S          PP   
Sbjct: 458  QAPLSLPASPPLQTSL---SPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLET 514

Query: 504  THSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGA---------APCP--- 551
              SL    L  P   L  PP    +  P L  PP    S              APCP   
Sbjct: 515  QSSLAPPSLQTPPASLTTPPL---ENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQA 571

Query: 552  -PNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPP--ASPGKA 608
             P+P  +  P      +  PP++P    SP        G P+ P   LA PP  A P  A
Sbjct: 572  PPSPLTTPPPETPSSIATPPPQAPPALASPPL-----QGLPSPPLSPLATPPPQAPPXLA 626

Query: 609  QPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPA 668
             PP       L++P +  +S   S  ++ S  AP+  +   +  P    F  PP P V A
Sbjct: 627  LPP-------LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAP----FSPPPSPPVQA 675

Query: 669  PFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPP-----TPQTTLTPLQESPVI 723
            PFSPP S P SP+   P+ A P++   P+    + P SPP     TP     P   +P +
Sbjct: 676  PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL 735

Query: 724  SKDQSPPPSPP--PSYHPP---PPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPE 778
                SPP SPP  PS  PP   PP    P + V     +     PL  P  PP  PPA  
Sbjct: 736  QVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKP--PPQAPPALA 793

Query: 779  EQDLSMADFPP---PEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQI--QPPGSP 833
               L     PP   P +A FS ++  P  P  +P   + P     +A  LQ+   PP SP
Sbjct: 794  TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVL---AAPLLQVPPSPPASP 850

Query: 834  --DPPPAPPAPAPASSAPG---HVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLL---- 884
                P  PP P P +S  G    +A  P   P        PP     + L  P L     
Sbjct: 851  TLQAPRRPPTPGPDTSVSGPRLTLALAPGPPP--------PPSRSPSSTLSGPDLAGHSS 902

Query: 885  ------QMVRLRSVGAPGGAPT------------PALGPSAPQKPLR-RALSGRASPVPA 925
                  + +R    G  GGA              PA     P  PL  R   G   P P 
Sbjct: 903  SATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWP- 961

Query: 926  PSSGLHAAVRLKACSLAASEGLSSAQP-NGPPEAEPRPPQSPASTASFIFSKGSRKLQLE 984
            P++G  +A  L  C++  +EG  SA P  G  +  P P  S    A+   +  S +   +
Sbjct: 962  PATGPGSADGL--CTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQ 1019

Query: 985  RPVSPETQADLQRNLVAELRS 1005
              +       LQ ++V  L S
Sbjct: 1020 ARLGELPLGALQASVVQHLLS 1040



 Score =  147 bits (371), Expect = 5e-35
 Identities = 238/896 (26%), Positives = 319/896 (35%), Gaps = 136/896 (15%)

Query: 241  APG--TPRAPGARDAVRIPTVDGRPRGTSGMGARVSLQALEAEAEAGAETEAMLQRHIDR 298
            APG  TPR PG+      P     P     +GA  ++        AG    A +     R
Sbjct: 21   APGLLTPRPPGSPR----PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76

Query: 299  VYRDDTFVGRSTGTRAP-PLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPH 357
                     RS GT +  P +RP +         +G  E   PA + SP           
Sbjct: 77   AGPT-----RSAGTSSRNPASRPPA---------SGRGERAPPAKNTSPGPVSSPGRASG 122

Query: 358  AVLPPTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWS 417
               P  +    L   +  T++R     A   S  S G     S P P +  P+ +     
Sbjct: 123  TTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMAR---- 178

Query: 418  HSQSSDTIVS---DGSTLSSKGGSEGQPES--STASNSVVPPPQGGSGRGSPSGGSTAEA 472
             S+++ T V       +   +  +EG  +S  S + +S   P      R S  GG    A
Sbjct: 179  RSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPA 238

Query: 473  SDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQ-- 530
            S +LS  S+  LS  + S    +  P  P        +GL     P   PP+ +      
Sbjct: 239  SRSLS-SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG 297

Query: 531  PQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGT 590
            P    P  T    G  A P PP P N+  P L       PP +    L+P S        
Sbjct: 298  PLSSSPLATPSPSGTKARPVPP-PDNAATP-LPATLPPSPPLATPLPLAPPS-------- 347

Query: 591  PTLPP--KGLAGPPASPGKAQPPKP-----ERVTSLRS-PGASVSSSLTSLCSSSSDPAP 642
            P+ PP  + L  PPA+P    PP       +   SL++ P   V  SLTS  S  + P+P
Sbjct: 348  PSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSP-SLQAPPSP 406

Query: 643  SDRSGPQILTPLGDRFVIPPH------PKVPAPFSPPPSKPRSPNPAAPALAAPAVVPG- 695
               S  Q  T LG   +   H      P+        PS+P S  P +P L AP  +P  
Sbjct: 407  LALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPAS 466

Query: 696  -PVSTT---DASPQSPP---------------TPQTTLTPLQESPVISKDQSPPPS--PP 734
             P+ T+     SP S P               +PQ  L+ L   P+ ++    PPS   P
Sbjct: 467  PPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTP 526

Query: 735  PSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNW--PPPPPPAPEEQDLSMADFPPPEE 792
            P+    PP    P +   AP   +TA  PL  P+   PP P P P +   S    PPPE 
Sbjct: 527  PASLTTPPLENLPSL---APPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPET 583

Query: 793  AFFSVASPEPAGPSG--------------SPELVSSPAASSSSATALQIQPPGSPDPPPA 838
               S+A+P P  P                SP     P A    A      PP  P  PP 
Sbjct: 584  PS-SIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPL 642

Query: 839  PPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGA 898
             P   P+  AP  +A    + P   S    PP +   +P  +P +       S   P  A
Sbjct: 643  SPLATPSPQAPNALAVHLLQAPF--SPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA 700

Query: 899  PTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLS-SAQPNGPPE 957
              P   P +P  P    +S  A+P P     L A       S  AS  +S SA P  PP 
Sbjct: 701  APPLQVPPSP--PASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATP--PPR 756

Query: 958  AEPR--------PPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQ 1009
              P         PP  PAS      +K            P+    L    +  L S    
Sbjct: 757  VPPLLAAPPLQVPPSPPASLPMSPLAKPP----------PQAPPALATPPLQALPSPPAS 806

Query: 1010 RPPQAP-------KKSPKAPPPVARKPSVGVP----PPASPSYPRAEPLTAPPTNG 1054
             P QAP         SP A PP    P +  P    PP+ P+ P  +    PPT G
Sbjct: 807  FPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPG 862



 Score =  138 bits (347), Expect = 3e-32
 Identities = 204/759 (26%), Positives = 278/759 (36%), Gaps = 129/759 (16%)

Query: 361  PPTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRH-PSSSSDTWSHS 419
            PP V   AL     R L         P + R+ G     + P+   R  P+ S+ T S +
Sbjct: 36   PPPVTPAAL-----RVLGAAGAVGRKPLAERA-GGIGGATIPESAPRAGPTRSAGTSSRN 89

Query: 420  QSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSG--RGSPSG--GSTAEASDT 475
             +S    S        G  E  P +   S   V  P   SG  R  P G  G    A +T
Sbjct: 90   PASRPPAS--------GRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEET 141

Query: 476  LS---IRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLP-PKPERKQQP 531
            ++      + + S  S   R+    P P   + ++ +R  A     +GLP P P  +   
Sbjct: 142  VARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT-EVGLPRPAPSAR--- 197

Query: 532  QLPRPPTTGGSEGAGAAP----CPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQ 587
              PRPPT G  +   +A       P+PA    P  S GG  + P S  R+LS S+   + 
Sbjct: 198  --PRPPTEGPRKSVSSASEHSTTEPSPAARRRP--SAGGGLQRPAS--RSLSSSA---TP 248

Query: 588  SGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGAS-----VSSSLTSLCSSS-SDPA 641
              +P        G P +P     PKP+ + +LR P  +      + +L  L SS  + P+
Sbjct: 249  LSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPS 308

Query: 642  PSDRSGPQILTPLGDRFVIPP-HPKVPAPFSPPPSKP-RSPNPAAPALAAPAVVPGPVST 699
            PS             R V PP +   P P + PPS P  +P P AP   +P+  P  + T
Sbjct: 309  PSGTKA---------RPVPPPDNAATPLPATLPPSPPLATPLPLAPP--SPSAPPS-LQT 356

Query: 700  TDASPQSPPT---PQTTLTPLQESP---VISKDQSPPPSPPPSYHPPPPPTKKPEVVVEA 753
              + P +PP+   P  T  P+Q  P    I   Q P     PS   PP P     +    
Sbjct: 357  LPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATT 416

Query: 754  PSASET--------------AEEPLQDPNWPPPPPP--APEEQDLSMADFPPPEEAFFSV 797
               S T               +  L  P+ P   PP   P +  LS+   PP + +    
Sbjct: 417  SLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPA 476

Query: 798  ASPEPAGPSGSPELVSSPAASSSSATALQ--IQPPGSPDPPPAPPA--PAPASSAPGHVA 853
             SP  +  +  P    S  AS S    L   I PP       APP+    PAS     + 
Sbjct: 477  VSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLE 536

Query: 854  KLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAP-QKPL 912
             LP   P        PP +   APL TP L           P  AP P   P +P   P 
Sbjct: 537  NLPSLAP--------PPLQTASAPLTTPHLET--------PPCPAPCPLQAPPSPLTTPP 580

Query: 913  RRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPP-------EAEPRPPQS 965
                S  A+P P     L A+  L+         L++  P  PP       +A P PP S
Sbjct: 581  PETPSSIATPPPQAPPAL-ASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPAS 639

Query: 966  PA----STASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKA 1021
            P     +T S           L+ P SP     +Q              PP +P  SP A
Sbjct: 640  PPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF----------SPPASPPVSPSA 689

Query: 1022 PPPVARKPSVGVP----PPASPSYPRAEPLTAPPTNGLP 1056
             PP    PS+  P    PP+ P+ P   P   PP    P
Sbjct: 690  TPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 728



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 96/417 (23%), Positives = 136/417 (32%), Gaps = 68/417 (16%)

Query: 662  PHPKVPAPFSP-PPSKPRSPNPAAPA---------------LAAPAVVPGPVSTTDASPQ 705
            P  + P   +P PP  PR P P  PA               LA  A   G  +  +++P+
Sbjct: 17   PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76

Query: 706  SPPTPQ---TTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEE 762
            + PT     ++  P    P   + +  PP+   S  P   P +        P   +    
Sbjct: 77   AGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRI 136

Query: 763  PLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSA 822
              ++         AP+   LS         A    + P P  PS  P +     A+ +  
Sbjct: 137  SAEETVARGKATEAPKRSALSAG-------ARRDTSGPTPGTPS--PAMARRSRAAGTEV 187

Query: 823  TALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPS 882
               +  P   P PP   P  +  SSA  H    P          GG  +      L + +
Sbjct: 188  GLPRPAPSARPRPPTEGPRKS-VSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSA 246

Query: 883  LLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLA 942
                   RS  +  G P     P+ P +P  + L     P   P     A     A    
Sbjct: 247  TPLSSPARSGPSARGTPR---APAHPSQPKPKGLQALRPPQVTPPRKDAAP----ALGPL 299

Query: 943  ASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAE 1002
            +S  L++  P+G  +A P PP   A+T           L    P SP     L       
Sbjct: 300  SSSPLATPSPSGT-KARPVPPPDNAATP----------LPATLPPSPPLATPL------- 341

Query: 1003 LRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQ 1059
                     P AP  SP APP +   PS    PPA+P       +T PP    P  Q
Sbjct: 342  ---------PLAPP-SPSAPPSLQTLPS----PPATPPSQAPPSMTTPPMQAPPSLQ 384



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 109/480 (22%), Positives = 146/480 (30%), Gaps = 112/480 (23%)

Query: 590  TPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSD------PAPS 643
            TP     GL   P  PG  +PP P    +LR  GA+ +     L   +        P  +
Sbjct: 16   TPAARAPGLL-TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESA 74

Query: 644  DRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNP-AAPALAAPAVVPGPVSTTDA 702
             R+GP        R      P        PP+K  SP P ++P  A+    PGP+     
Sbjct: 75   PRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGL 134

Query: 703  SPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEE 762
               +  T         E+P   K  +           P P T  P +   + +A      
Sbjct: 135  RISAEET--VARGKATEAP---KRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL 189

Query: 763  PLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAG---PSGSPELVSSPAASS 819
            P   P+  P PP     + +S A       +  S   P PA    PS    L   PA+ S
Sbjct: 190  PRPAPSARPRPPTEGPRKSVSSA-------SEHSTTEPSPAARRRPSAGGGL-QRPASRS 241

Query: 820  SSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLV 879
             S++A               P  +PA S P                  G PR        
Sbjct: 242  LSSSAT--------------PLSSPARSGPS---------------ARGTPRAPAHPSQP 272

Query: 880  TPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSG-RASPVPAPSSGLHAAVRLKA 938
             P  LQ +R   V  P     PALGP +       + SG +A PVP P +          
Sbjct: 273  KPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDN---------- 322

Query: 939  CSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRN 998
                A+  L +  P  PP A P P   P+                               
Sbjct: 323  ----AATPLPATLPPSPPLATPLPLAPPS------------------------------- 347

Query: 999  LVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHT 1058
                         P AP      P P A  PS   P   +P       L   P   +PH+
Sbjct: 348  -------------PSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHS 394


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score =  142 bits (359), Expect = 1e-33
 Identities = 195/733 (26%), Positives = 277/733 (37%), Gaps = 97/733 (13%)

Query: 313 RAPPLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRC 372
           R PP   P +L V G  G  G  +PL+        AT + +  P A    T    A GR 
Sbjct: 34  RPPPPVTPAALRVLGAAGAVG-RKPLAERAGGIGGAT-IPESAPRAGPTRTSRPPASGRG 91

Query: 373 SLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPS--SSSDTWSHSQSSD----TIV 426
                ++    + SP  V S GR S  + P P  +     S+ +T +  ++++    + +
Sbjct: 92  ERAPPAK----NTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSAL 147

Query: 427 SDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTL-SIRSSGQLS 485
           S G+   + G + G P  + A  S     + G  R +PS            S+ S+ + S
Sbjct: 148 SAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS 207

Query: 486 GRSVSLRKLKRPPP------PPRRTHSLHQRGLAVP--DGPL--GLPPKPERKQQP---- 531
               S    +RP        P  R+ S     L+ P   GP   G P  P    QP    
Sbjct: 208 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKG 267

Query: 532 -QLPRPP--TTGGSEGAGA-APCPPNPANSWVPGLSPGGSRRPPRS--PERTLSPSSGYS 585
            Q  RPP  T    + A A  P   +P  +  P   P  S  P     P    +P S  +
Sbjct: 268 LQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQAT 327

Query: 586 SQSGTPTLPPKG--LAGPPASPGKAQPPKPERVTSL---RSPGASVSSSLTSLCSSSSDP 640
           +  G+PTL      L  PP SP    PP+     +L   ++P +  +S   S  ++ S  
Sbjct: 328 TSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQ 387

Query: 641 APSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTT 700
           AP+  +   +  P    F  PP P V APFSPP S P SP+   P+ A P++   P+   
Sbjct: 388 APNALAVHLLQAP----FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVP 443

Query: 701 DASPQSPPTPQTTLTPLQESPVISKD----QSPPPSPPPSYHPPP------PPTKKPEVV 750
            + P SPP   +   P Q  P ++        PPP  PP+   PP      PP   P   
Sbjct: 444 PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQA 503

Query: 751 VEAPSA----SETAEEPLQDP--------NWPPPPPPAPEEQDLSMADFPPPEEAF---- 794
             +PSA    S  A  P Q P          PP PP +P  Q       P P+ +     
Sbjct: 504 PFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPR 563

Query: 795 --FSVASPEPAGPSGSP-ELVSSP--AASSSSATALQIQPPG---------SPDPPP--- 837
              ++A   P  PS SP   +S P  A  SSSAT+   +  G         +  PPP   
Sbjct: 564 LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAE 623

Query: 838 -----------APPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQM 886
                       P  P     APG     P     G + G     E  G    TP+   +
Sbjct: 624 LAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGAL 683

Query: 887 VRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEG 946
               S G  GG      G  A  +  ++A  G   P+ A  + +   +  +   LAA+EG
Sbjct: 684 DPGPSPGTSGGKAAAGAGAGASSRSPKQARLGEL-PLGALQASVVQHLLSRTLLLAAAEG 742

Query: 947 LSSAQPNGPPEAE 959
            +     GP  AE
Sbjct: 743 AAGGSGGGPGGAE 755



 Score =  123 bits (308), Expect = 1e-27
 Identities = 187/683 (27%), Positives = 249/683 (36%), Gaps = 167/683 (24%)

Query: 386  SPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESS 445
            +PA++R LG   +V       R       T   S         G T +S+  + G+ E +
Sbjct: 40   TPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRA-----GPTRTSRPPASGRGERA 94

Query: 446  TASNSVVPPPQGGSGRGS------PSG--GSTAEASDTLS---IRSSGQLSGRSVSLRKL 494
              + +  P P    GR S      P G  G    A +T++      + + S  S   R+ 
Sbjct: 95   PPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRD 154

Query: 495  KRPPPPPRRTHSLHQRGLAVPDGPLGLP-PKPERKQQPQLPRPPTTGGSEGAGAAP---- 549
               P P   + ++ +R  A     +GLP P P  +     PRPPT G  +   +A     
Sbjct: 155  TSGPTPGTPSPAMARRSRAAGT-EVGLPRPAPSAR-----PRPPTEGPRKSVSSASEHST 208

Query: 550  CPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQ 609
              P+PA    P  S GG  + P S  R+LS S+   +   +P        G P +P    
Sbjct: 209  TEPSPAARRRP--SAGGGLQRPAS--RSLSSSA---TPLSSPARSGPSARGTPRAPAHPS 261

Query: 610  PPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAP 669
             PKP+ + +LR P          +     D AP+       L PL    +  P P  P  
Sbjct: 262  QPKPKGLQALRPP---------QVTPPRKDAAPA-------LGPLSSSPLATPSPSAPPS 305

Query: 670  FSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPT----PQTTLTPLQESPVISK 725
             S PPS    P+P       PA  P   +T+  SP    T    P   L+PL   P    
Sbjct: 306  PSAPPSLQTLPSP-------PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP---- 354

Query: 726  DQSPPP-SPPPSYHPPPPPTKKPEVVVEAPSA---SETAEEPLQDPNWPPPPPPAPEEQD 781
             Q+PP  + PP   PP PP   P   +  PS    +  A   LQ P  PPP PP      
Sbjct: 355  PQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPV----- 409

Query: 782  LSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQI------QPPGSPDP 835
               A F PP       ASP P  PS +P    S A  S +A  LQ+       PP SP  
Sbjct: 410  --QAPFSPP-------ASP-PVSPSATPP---SQAPPSLAAPPLQVPPSPPASPPMSPSA 456

Query: 836  PPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAP 895
             P P AP P ++ P  +AK P +          PP       L TP L Q +       P
Sbjct: 457  TPPPQAPPPLAAPPLQLAKPPPQ---------APPA------LATPPL-QALPSPPASFP 500

Query: 896  GGAPTPALGPSA--PQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPN 953
            G AP     PSA  P  PL       A+P P     L A +                   
Sbjct: 501  GQAP---FSPSASLPMSPL-------ATPPPQAPPVLAAPLL------------------ 532

Query: 954  GPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQ 1013
               +  P PP SP   A              RP +P               S+S  R   
Sbjct: 533  ---QVPPSPPASPTLQAP------------RRPPTPGPDT-----------SVSGPRLTL 566

Query: 1014 APKKSPKAPPPVARKPSVGVPPP 1036
            A   +P  PPP +R PS  +  P
Sbjct: 567  A--LAPGPPPPPSRSPSSTLSGP 587



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 128/513 (24%), Positives = 172/513 (33%), Gaps = 110/513 (21%)

Query: 590  TPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSD------PAPS 643
            TP     GL   P  PG  +PP P    +LR  GA+ +     L   +        P  +
Sbjct: 16   TPAARAPGLL-TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESA 74

Query: 644  DRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNP-AAPALAAPAVVPGPVS---- 698
             R+GP        R   PP          PP+K  SP P ++P  A+    PGP+     
Sbjct: 75   PRAGPT-------RTSRPPASGRGE--RAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGL 125

Query: 699  ------------TTDASPQSP-----------PTPQTTLTPLQESPVISKDQSPPPSPPP 735
                         T+A  +S            PTP T    +      +  +   P P P
Sbjct: 126  RISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAP 185

Query: 736  SYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFF 795
            S  P PP T+ P   V + S   T E           P PA   +  +      P     
Sbjct: 186  SARPRPP-TEGPRKSVSSASEHSTTE-----------PSPAARRRPSAGGGLQRPASRSL 233

Query: 796  S-----VASPEPAGPS--GSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSA 848
            S     ++SP  +GPS  G+P   + P+            P  +P    A PA  P SS+
Sbjct: 234  SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 293

Query: 849  PGHVAKLPQKEPVGCSKGGGPPR-EDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSA 907
            P     L    P        PP  + + +P  TP         S+G+P    T +  PS 
Sbjct: 294  P-----LATPSPSAPPSPSAPPSLQTLPSPPATPPSQATT---SLGSPTLQATHSFLPSP 345

Query: 908  PQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPA 967
            P  PL       A+P P                  A   L+      PP     PP SP 
Sbjct: 346  PLSPL-------ATPPPQ-----------------APPALALPPLQAPPSPPASPPLSPL 381

Query: 968  STASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVAR 1027
            +T S           L+ P SP     +Q              PP +P  SP A PP   
Sbjct: 382  ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF----------SPPASPPVSPSATPPSQA 431

Query: 1028 KPSVGVP----PPASPSYPRAEPLTAPPTNGLP 1056
             PS+  P    PP+ P+ P   P   PP    P
Sbjct: 432  PPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 464


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score =  140 bits (353), Expect = 7e-33
 Identities = 193/722 (26%), Positives = 268/722 (37%), Gaps = 100/722 (13%)

Query: 311 GTRAPPL--TRPMSLAVPGLTGGAGPAEPLSP-AMSISPQATYLSKLIPHAVLPPTVDVV 367
           G RAPP   T P  ++ PG   G     PL    + IS + T        A   P    +
Sbjct: 100 GERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEA---PKRSAL 156

Query: 368 ALGRCSLRTLSRCSLHSASPASVR---SLGRFSSVSSPQPRSR-HPSSSSDTWSHSQSSD 423
           + G  + R  S  +  + SPA  R   + G    +  P P +R  P +     S S +S+
Sbjct: 157 SAG--ARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 214

Query: 424 TIVSDGSTLS----SKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIR 479
              ++ S  +    S GG   +P S + S+S  P       R  PS   T  A    S  
Sbjct: 215 HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATP--LSSPARSGPSARGTPRAPAHPS-- 270

Query: 480 SSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQ---PQLPRP 536
                  +   L+ L+ P   P R  +    G  +   PL  P      Q    P LP  
Sbjct: 271 -----QPKPKGLQALRPPQVTPPRKDAAPALG-PLSSSPLATPSPSAALQSQAPPTLPAT 324

Query: 537 PTTGGSEGAGAAPCP-PNPANSWVPGLS--PGGSRRPPRSPERTLSPSSGYSSQSGTPTL 593
           P +       A P P   P+ S  P L   P     PP     +L   +  ++ S  P+ 
Sbjct: 325 PHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSP 384

Query: 594 PPKGLAGPP--ASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQIL 651
           P   LA PP  A P  A PP       L++P +  +S   S  ++ S  AP+  +   + 
Sbjct: 385 PLSPLATPPPQAPPALALPP-------LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ 437

Query: 652 TPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQ 711
            P    F  PP P V APFSPP S P SP+   P+ A P++   P+    + P SPP   
Sbjct: 438 AP----FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP 493

Query: 712 TTLTPLQESPVISKD----QSPPPSPPPSYHPPP------PPTKKPEVVVEAPSA----S 757
           +   P Q  P ++        PPP  PP+   PP      PP   P     +PSA    S
Sbjct: 494 SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMS 553

Query: 758 ETAEEPLQDP--------NWPPPPPPAPEEQDLSMADFPPPEEAF------FSVASPEPA 803
             A  P Q P          PP PP +P  Q       P P+ +        ++A   P 
Sbjct: 554 PLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPP 613

Query: 804 GPSGSP-ELVSSP--AASSSSATALQIQPPG---------SPDPPP-------------- 837
            PS SP   +S P  A  SSSAT+   +  G         +  PPP              
Sbjct: 614 PPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSR 673

Query: 838 APPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGG 897
            P  P     APG     P     G + G     E  G    TP+   +    S G  GG
Sbjct: 674 GPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGG 733

Query: 898 APTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPE 957
                 G  A  +  ++A  G   P+ A  + +   +  +   LAA+EG +     GP  
Sbjct: 734 KAAAGAGAGASSRSPKQARLGEL-PLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGG 792

Query: 958 AE 959
           AE
Sbjct: 793 AE 794



 Score =  128 bits (322), Expect = 3e-29
 Identities = 179/684 (26%), Positives = 249/684 (36%), Gaps = 128/684 (18%)

Query: 429  GSTLSSKGGSEGQPESSTAS--NSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSG---- 482
            G+T+       G   S+  S  N    PP  G G  +P   +T+    +   R+SG    
Sbjct: 67   GATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRP 126

Query: 483  -------------------------QLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDG 517
                                     + S  S   R+    P P   + ++ +R  A    
Sbjct: 127  GPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAA-GT 185

Query: 518  PLGLP-PKPERKQQPQLPRPPTTGGSEGAGAA----PCPPNPANSWVPGLSPGGSRRPPR 572
             +GLP P P  +     PRPPT G  +   +A       P+PA    P  S GG  + P 
Sbjct: 186  EVGLPRPAPSAR-----PRPPTEGPRKSVSSASEHSTTEPSPAARRRP--SAGGGLQRPA 238

Query: 573  SPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTS 632
            S  R+LS S   ++   +P        G P +P     PKP+ + +LR P          
Sbjct: 239  S--RSLSSS---ATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPP---------Q 284

Query: 633  LCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPA--LAAP 690
            +     D AP+       L PL    +  P P        PP+ P +P+ ++    LA P
Sbjct: 285  VTPPRKDAAPA-------LGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATP 337

Query: 691  AVVPGPVSTTDAS----PQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKK 746
              +  P  +   S    P  P TP +  T    SP +    S  PSPP S    PPP   
Sbjct: 338  LPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAP 397

Query: 747  PEVV---VEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPE----EAFFSVAS 799
            P +    ++AP  S  A  PL     P P  P      L  A F PP     +A FS  +
Sbjct: 398  PALALPPLQAP-PSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 456

Query: 800  PEPAGPSGSPELVSSPAASSSSATALQI------QPPGSPDPPPAPPAPAPASSAPGHVA 853
              P  PS +P    S A  S +A  LQ+       PP SP   P P AP P ++ P  +A
Sbjct: 457  SPPVSPSATP---PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLA 513

Query: 854  KLPQKEPVGCSKG-----GGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPA-----L 903
            K P + P   +         PP    G    +PS    +   +   P   P  A     +
Sbjct: 514  KPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQV 573

Query: 904  GPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPP 963
             PS P  P  +A   R  P P P + +            +   L+ A   GPP   P P 
Sbjct: 574  PPSPPASPTLQA--PRRPPTPGPDTSV------------SGPRLTLALAPGPP---PPPS 616

Query: 964  QSPASTASFIFSKGSRKLQLERP-------VSPETQADLQRNLVAELRSISEQRPPQAPK 1016
            +SP+ST S     G        P         PE  A       AEL +      P A  
Sbjct: 617  RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACH----PAAWS 672

Query: 1017 KSPKAPPPVARKPSVGVPPPASPS 1040
            + P   PP+A + + G P P  P+
Sbjct: 673  RGP--APPLAFRGAPGAPLPWPPA 694



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 125/517 (24%), Positives = 173/517 (33%), Gaps = 79/517 (15%)

Query: 590  TPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSD------PAPS 643
            TP     GL   P  PG  +PP P    +LR  GA+ +     L   +        P  +
Sbjct: 16   TPAARAPGLL-TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESA 74

Query: 644  DRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNP-AAPALAAPAVVPGPVS---- 698
             R+GP        R      P        PP+K  SP P ++P  A+    PGP+     
Sbjct: 75   PRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGL 134

Query: 699  ------------TTDASPQSP-----------PTPQTTLTPLQESPVISKDQSPPPSPPP 735
                         T+A  +S            PTP T    +      +  +   P P P
Sbjct: 135  RISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAP 194

Query: 736  SYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFF 795
            S  P PP T+ P   V + S   T E           P PA   +  +      P     
Sbjct: 195  SARPRPP-TEGPRKSVSSASEHSTTE-----------PSPAARRRPSAGGGLQRPASRSL 242

Query: 796  S-----VASPEPAGPS--GSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSA 848
            S     ++SP  +GPS  G+P   + P+            P  +P    A PA  P SS+
Sbjct: 243  SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 302

Query: 849  PGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALG--PS 906
            P     L    P    +   PP      P  +    Q+     +  P  +  P+L   PS
Sbjct: 303  P-----LATPSPSAALQSQAPPTLPA-TPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPS 356

Query: 907  APQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLA---ASEGLSSAQPNGPPEAEPRPP 963
             P  P  +A +   SP    +     +  L   +     A   L+      PP     PP
Sbjct: 357  PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPP 416

Query: 964  QSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPP 1023
             SP +T S           L+ P SP     +Q              PP +P  SP A P
Sbjct: 417  LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF----------SPPASPPVSPSATP 466

Query: 1024 PVARKPSVGVP----PPASPSYPRAEPLTAPPTNGLP 1056
            P    PS+  P    PP+ P+ P   P   PP    P
Sbjct: 467  PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 503



 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 165/638 (25%), Positives = 220/638 (34%), Gaps = 139/638 (21%)

Query: 472  ASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQ-- 529
            A+ T + R+ G L+ R     +    PPPP    +L   G A   G +G  P  ER    
Sbjct: 13   AARTPAARAPGLLTPRPPGSPR----PPPPVTPAALRVLGAA---GAVGRKPLAERAGGI 65

Query: 530  -----QPQLPR--PPTTGGSEGAGAAPCPPN--------PANSWVPG--LSPG---GSRR 569
                     PR  P  + G+     A  PP         PA +  PG   SPG   G+ R
Sbjct: 66   GGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTR 125

Query: 570  PPRSPERTLSPSSGYSSQSGTPTLPPKGLA---GPPASPGKAQPPKPERVTSLRSPGASV 626
            P    ++ L  S+  +   G  T  PK  A   G         P  P    + RS  A  
Sbjct: 126  PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT 185

Query: 627  SSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPN----- 681
               L         PAPS R  P    P         H        P P+  R P+     
Sbjct: 186  EVGLPR-------PAPSARPRPPTEGPRKSVSSASEHSTT----EPSPAARRRPSAGGGL 234

Query: 682  --PAAPALAAPAVVPGPVSTTDAS-PQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYH 738
              PA+ +L++ A    P+S+   S P +  TP+    P Q  P   +   PP   PP   
Sbjct: 235  QRPASRSLSSSAT---PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKD 291

Query: 739  PPPP--PTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFS 796
              P   P     +   +PSA+  ++ P       P  P  P    L+     P       
Sbjct: 292  AAPALGPLSSSPLATPSPSAALQSQAP-------PTLPATPHSSSLTCQLATP-----LP 339

Query: 797  VASPEPAGPSGSPELVSSPAASSSSATA------LQIQPPGSPDPPPAPPAPAPASSAPG 850
            +A P P+ P     L S PA   S AT       LQ      P PP +P A  P   AP 
Sbjct: 340  LAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA-TPPPQAPP 398

Query: 851  HVAKLPQKEPVGCSKGGGPPREDVGAPLVTPS--LLQMVRLRSVGAPGGAPTPALGPSAP 908
             +A  P + P        PP     +PL TPS      + +  + AP   P        P
Sbjct: 399  ALALPPLQAPPS------PPASPPLSPLATPSPQAPNALAVHLLQAPFSPP--------P 444

Query: 909  QKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPAS 968
              P++   S  ASP  +PS+   +          A   L++     PP     PP SP++
Sbjct: 445  SPPVQAPFSPPASPPVSPSATPPSQ---------APPSLAAPPLQVPPSPPASPPMSPSA 495

Query: 969  TASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARK 1028
            T                P +P   A                 P Q  K  P+APP +A  
Sbjct: 496  TPP--------------PQAPPPLA---------------APPLQLAKPPPQAPPALATP 526

Query: 1029 PSVGVP-PPAS-----PSYPRA----EPLTAPPTNGLP 1056
            P   +P PPAS     P  P A     PL  PP    P
Sbjct: 527  PLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPP 564


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  140 bits (352), Expect = 9e-33
 Identities = 201/809 (24%), Positives = 284/809 (35%), Gaps = 131/809 (16%)

Query: 315  PPLTRPMSLAVPGLTGGAGPAEPLS-PAMSISPQAT-----------YLSKLIPHAVLP- 361
            P    P +   P  T    P  P S P+ S+ P  T           + S L P A  P 
Sbjct: 709  PVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPK 768

Query: 362  --PTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHS 419
              PT D  A    S +        S SP     LG   S  + +P ++  S+  DT   +
Sbjct: 769  ECPTEDSGASATASSKGTLTYLADSPSP-----LGVSVSPQTKRPPTKKGSAGPDTPIGN 823

Query: 420  QSSDTIVSDGSTLSSKGGS-EGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASD---T 475
             SS     + S L     S +G  +S   ++S  PP    S +G+P+  +    S    T
Sbjct: 824  LSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPP----SPKGAPTPSAVTPLSPKGVT 879

Query: 476  LSIRSSGQLSGRSVSLRKLKRPPPPPRR------THSLHQRGLAVPDGPLGLPPKPERKQ 529
            L  + +   S  ++   K     P P++      T S  ++  A P  P G+P  P  K 
Sbjct: 880  LPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATP-APKGIPASPSPKG 938

Query: 530  QPQLPR--PPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQ 587
             P  P   PP+  G         P  P+  W P   P  +   P+    T SP    +  
Sbjct: 939  APTPPAATPPSPKGG--------PATPSPKWAP-TPPAATPPSPKGGPATPSPKGAPTPP 989

Query: 588  SGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSG 647
            + TP  P     G PA+P     P P  VT     G+  ++      S+     P    G
Sbjct: 990  AATPPSPK----GGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKG 1045

Query: 648  PQILTPLGDRFVIPPHPKVPAPFSPP--PSKPRSPNPAA---------PALAAPAVVPGP 696
                TPL       P   +P+P   P  PS   +P P A         PA  +P   P P
Sbjct: 1046 SPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMP 1105

Query: 697  VSTTDASPQ----SPPTPQTTLTPLQESPVISKD-QSPPPSPPPSYHPPPPPTKKPEVVV 751
             + T  SP+    +PP      TP    P       +PPP   P+     PP+ K  +  
Sbjct: 1106 PAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLAT 1165

Query: 752  EAPSASETAEEPLQDPNWPPPPP------PAPEEQDLSMADFPPPEEAFFSVASPE--PA 803
              P  + T       P   PP P      P+P+    + A  PP  +   +  SP+  P 
Sbjct: 1166 PPPKGAPTT------PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPT 1219

Query: 804  GPSGSPE------LVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQ 857
             P+ +P          SP  + ++  A    P G P  PP   AP P ++ P  +     
Sbjct: 1220 TPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSL----- 1274

Query: 858  KEPVGCSKGGGPPREDVGAP---LVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRR 914
                   KGG       GAP   +VTP            +P G P  +    AP  P   
Sbjct: 1275 -------KGGLATPPHKGAPNPAVVTPP-----------SPKGGPATSPPKGAPTPPAAT 1316

Query: 915  ALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPN---GPPEAEPRP-PQSPASTA 970
              S + SP   P  G      +   S   +  L +  P+   GP     +  P  PA+T 
Sbjct: 1317 PPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATP 1376

Query: 971  SFIFSKGSRKLQLER-PVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAP--PPVAR 1027
            S            +R P  P  + D     V           P +PKK+P  P     A 
Sbjct: 1377 SHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVI----------PLSPKKAPATPVTREGAA 1426

Query: 1028 KPSVG--VPPPASPSYPRAEPLTAPPTNG 1054
             PS G   PP  +P   +  P T+ P  G
Sbjct: 1427 TPSKGDLTPPAVTPVSLKKAPATSAPKGG 1455



 Score =  136 bits (342), Expect = 1e-31
 Identities = 184/722 (25%), Positives = 250/722 (34%), Gaps = 80/722 (11%)

Query: 386  SPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPE-- 443
            SP    +   F   +S  P +  PS      +         +  +TL S  G    P   
Sbjct: 1018 SPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLK 1077

Query: 444  -SSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPR 502
             + T   +  P P+GG    SP G     A+   S +         ++    K  P  P 
Sbjct: 1078 GAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGG-------LATPPHKGAPTTPA 1130

Query: 503  RTHSLHQRGLAVPDGPLGLPPKPER---KQQPQLPRPPTTGGSEGAGAAPCPPN-----P 554
             T    + GLA P  P G P  P       +  L  PP  G      A P  P      P
Sbjct: 1131 ATPPSPKGGLATPP-PKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATP 1189

Query: 555  ANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGP-----PASPGKAQ 609
            +    P  +P  +   P+    T SP    ++ + TP  P  GLA P     P +P  A 
Sbjct: 1190 SPKGAP-TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPA-AT 1247

Query: 610  PPKPERVTSLRSP-GASVSSSLT--SLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKV 666
            PP P+   +   P GA    + T  SL    + P       P ++TP   +      P  
Sbjct: 1248 PPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPK 1307

Query: 667  PAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVI--S 724
             AP +PP + P SP   +P    P   P P + T  SP+  PT   T    +  P    S
Sbjct: 1308 GAP-TPPAATPPSPK-GSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSS 1365

Query: 725  KDQSPPPSPPPSYHPPP---PPTKKPEVVVEAPSASETAEE--PLQDPNWPPPPPPAPEE 779
            K+   PP+  PS+   P   PP+ K    + +P    T+    PL     P  P      
Sbjct: 1366 KEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGA 1425

Query: 780  QDLSMADFPPPEEAFFSVA-SPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPA 838
               S  D  PP     S+  +P  + P G P   SS        T   + PP SP  PPA
Sbjct: 1426 ATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSS----KGDPTLPAVTPP-SPKEPPA 1480

Query: 839  P--------PAPAPASSAPGHVAKLPQKEPVGCSKGGGPP--REDVGAPLVT-------- 880
            P        P  APA+ AP     LP   P    +    P  R D  AP  T        
Sbjct: 1481 PKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPA 1540

Query: 881  ---PSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLK 937
               P    +    +V +P   P       AP  P  +  S   +  P+   G  +   L 
Sbjct: 1541 TLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELL 1600

Query: 938  ACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQR 997
                  S     A P  P    P P + PA+ A     KG+       PV+P +  D   
Sbjct: 1601 IPPAVTSPSPKEA-PTPPAVTPPSPEKGPATPAP----KGT---PTSPPVTPSSLKDSPT 1652

Query: 998  NLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPH 1057
            +  A +        PQA K  P    P A K  +  P P S       P+   PT   P 
Sbjct: 1653 S-PASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPES------TPIITAPTRKGPQ 1705

Query: 1058 TQ 1059
            T+
Sbjct: 1706 TK 1707



 Score =  130 bits (327), Expect = 7e-30
 Identities = 208/833 (24%), Positives = 297/833 (35%), Gaps = 129/833 (15%)

Query: 311  GTRAPPLTRPMSLAVPGLTGGAGPAE--PLSP-AMSISPQATYLSKLI--------PHAV 359
            G++  P T   S   P   G   P+   PLSP  +++ P+ T    ++        P   
Sbjct: 845  GSKDSPATTH-SPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATP 903

Query: 360  LPPTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRH-PSSSSDTWSH 418
             P     +++   S +           PAS    G  +  ++  P  +  P++ S  W+ 
Sbjct: 904  APKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAP 963

Query: 419  SQSSDTIVSDGSTLSSKGG-SEGQPESSTASNSVVPP-PQGGSGRGSPSGGSTAEASDTL 476
            +  + T        S KGG +   P+ +    +  PP P+GG    SP G  T  A    
Sbjct: 964  TPPAAT------PPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPP 1017

Query: 477  SIRSSGQLSG--RSVSLRKLKRPPPP----------------PRRTHSLHQRGLAVPD-- 516
            S + S   +   +  S      PP P                P  T    + G A P   
Sbjct: 1018 SPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLK 1077

Query: 517  ----GPLGLPPKPERKQQPQLPR----PPTTGGSEGAGAAPCPPNPANSWVPGLSP---- 564
                 P   PP P+       P+    PP        G    PP+      P  +P    
Sbjct: 1078 GAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPK 1137

Query: 565  GGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGL-----AGPPASPGKAQPPKPERVTSL 619
            GG   PP     T   ++  S + G  T PPKG      A PP+  G    P P+   + 
Sbjct: 1138 GGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPT- 1196

Query: 620  RSPGASVSSSLTSLCSSSSDPAP--------SDRSGPQILTPLG---DRFVIPPHPKVPA 668
             +P A+  S    L + S   AP        S + G    +P G        PP PK   
Sbjct: 1197 -TPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPK-GG 1254

Query: 669  PFSPPPSKPRSPNPAAP-----ALAAPAV--VPGPVSTTDASPQSPPT---PQTTLTPLQ 718
            P +PPP    +P  A P      LA P     P P   T  SP+  P    P+   TP  
Sbjct: 1255 PATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPA 1314

Query: 719  ESPVISKDQ--SPPP--SPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPP 774
             +P   K    +PPP  +P P    PP P   P +    PS+      P      P PP 
Sbjct: 1315 ATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTP-SSKEGPTPPA 1373

Query: 775  PAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPD 834
              P  +       P P+      A P P G   SP ++     S   A A  +   G+  
Sbjct: 1374 ATPSHKGGPAMTPPSPKRG---PAIPSPKGDPTSPAVIP---LSPKKAPATPVTREGAAT 1427

Query: 835  PPPA---PPAPAPASSAPGHVAKLPQKEPVGCSKGGGP--PREDVGAPLVTPSLLQMVRL 889
            P      PPA  P S         P+  P   S  G P  P     +P   P+  Q+   
Sbjct: 1428 PSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATS 1487

Query: 890  RS------VGAPGGAPT-PALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLA 942
             S        AP GAPT PA+ PS+P K +    S R  P+ AP++ L +  +    +LA
Sbjct: 1488 SSPKKAPATPAPMGAPTLPAVIPSSP-KEVPATPSSRRDPI-APTATLLS--KKTPATLA 1543

Query: 943  ASEGL-----SSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQ--ADL 995
              E L     +   P   P A P P ++PA+ +S       ++      V+P T   A  
Sbjct: 1544 PKEALIPPAMTVPSPKKTP-AIPTPKEAPATPSS-------KEASSPPAVTPSTYKGAPS 1595

Query: 996  QRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLT 1048
             + L+     I       +PK++P  P      P  G   PA    P + P+T
Sbjct: 1596 PKELL-----IPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVT 1643



 Score =  128 bits (322), Expect = 3e-29
 Identities = 216/945 (22%), Positives = 322/945 (34%), Gaps = 138/945 (14%)

Query: 160  PDEDNISFCSQTTSYVAESSTAEDALSIRSEMIQRKGSTFRPHDSFPKSGKSGRRRRERR 219
            PD +++   +  +S + +  T +D  ++ + +   +G+ F P     ++G + ++     
Sbjct: 510  PDPEDLK--NLPSSVLVKFPTQKDLQTVPASL---EGAPFSP----AQAGLTTKKDPTVL 560

Query: 220  STVLGLPQHVQKELGLRNEREAPGTPRAPGARDAVRIPTVDGRPRG--TSGMGARVSLQA 277
              V   P++        +  E P +P A  A+ ++  P   G+P    TS +G   S   
Sbjct: 561  PLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASV 620

Query: 278  LEAEAEAGAETEAMLQRH---------IDRVYRDDTFVGRSTGTRAPPLTRPMSLAVPGL 328
            ++ ++ AG ++   L +                D   V  +T       T   S  + G 
Sbjct: 621  IKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGT 680

Query: 329  TGGAGPAEPLSPA-MSISPQATYLSKLIPHAVLP-----PTVDVVALGRCSLRTLSRCSL 382
               A    P+    ++  P     S+  P A  P     P   +V          S    
Sbjct: 681  VSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLP 740

Query: 383  HSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQP 442
             + +P   + +   S  S+  P +   SS  +  +    +    S   TL+    S    
Sbjct: 741  PAGTPPGTKKVDGISHTSALAPVA---SSPKECPTEDSGASATASSKGTLTYLADSPSPL 797

Query: 443  ESSTASNSVVPPPQGGS-GRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPP 501
              S +  +  PP + GS G  +P G  ++  S       +  L   S+S +  K  P   
Sbjct: 798  GVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPV----EASFLPENSLSFQGSKDSPATT 853

Query: 502  RRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTG---GSEGAGAAPCPPNPANSW 558
                    +G   P     L PK       + P P         EG      P  PA   
Sbjct: 854  HSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEG------PATPAPKQ 907

Query: 559  VPGLSPGGSRRPPRSPERTLSPSSGYSSQS--GTPTLP---PKGLAGPPASPGKAQPPKP 613
             P LS   S   P+    T +P    +S S  G PT P   P    G PA+P     P P
Sbjct: 908  APALSMTSSS--PKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTP 965

Query: 614  ERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLG---DRFVIPPHPK---VP 667
               T     G   + S     +  +   PS + GP   +P G      V PP PK     
Sbjct: 966  PAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAA 1025

Query: 668  APF-----SPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQS-PPTPQTTLTPLQESP 721
             PF     +PP + P SP  +  A   P   P   + T  SP+  P TP     P   + 
Sbjct: 1026 TPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAA 1085

Query: 722  VISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQD 781
                 +  P +P P   P PP    P     +P            P  P   PP+P+   
Sbjct: 1086 TPPSPKGGPATPSPKGAPMPPAATPP-----SPKGGLATPPHKGAPTTPAATPPSPKGGL 1140

Query: 782  LSMADFPPPEEAFFSVAS--PEPAGPSGSPELVSSPAASSSSATALQIQPPG---SPDPP 836
             +    PPP+ A  + A+  P P G   +P     P  + ++  A    P G   +P P 
Sbjct: 1141 AT----PPPKGAPTTPAATPPSPKGGLATPP----PKGAPTTPAATPPSPKGGLATPSPK 1192

Query: 837  PAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPG 896
             AP  PA    +P      P  +    +    PP    G  L TPS            P 
Sbjct: 1193 GAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGG--LATPS------------PK 1238

Query: 897  GAPT-PALGPSAPQKPLRRALSGRASPVP--APSSGLHAAVRLKACSLAASEGLSSAQPN 953
            GAPT PA  P +P+        G A+P P  AP+        LK        GL++    
Sbjct: 1239 GAPTTPAATPPSPK-------GGPATPPPKGAPTPPAATPPSLKG-------GLATPPHK 1284

Query: 954  GPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQ 1013
            G P      P SP    +    KG+       P  P                      P 
Sbjct: 1285 GAPNPAVVTPPSPKGGPATSPPKGA-------PTPPAAT-------------------PP 1318

Query: 1014 APKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHT 1058
            +PK SP  PPP        V PP+    P   P T P + G P T
Sbjct: 1319 SPKGSPGTPPPKGAPTPPAVTPPSPKGTPTL-PATTPSSKGGPTT 1362



 Score =  124 bits (312), Expect = 4e-28
 Identities = 211/860 (24%), Positives = 297/860 (34%), Gaps = 175/860 (20%)

Query: 315  PPLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSK---LIPHAVLPPTVDVVALGR 371
            PP  +    A P   G + P     P+   SP AT L K     P A LP        G 
Sbjct: 1016 PPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKG----GP 1071

Query: 372  CSLRTLSRCSLHSASPASVRS-LGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGS 430
             +       +  +A+P S +      S   +P P +  P S     +         +  +
Sbjct: 1072 ATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAA 1131

Query: 431  TLSS-KGG-SEGQPESSTASNSVVPP-PQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGR 487
            T  S KGG +   P+ +  + +  PP P+GG     P G  T  A+   S +        
Sbjct: 1132 TPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGG------ 1185

Query: 488  SVSLRKLKRPPPPPRRTHSLHQRGLAVPDG------PLGLPPKPERKQQPQLPR-PPTTG 540
             ++    K  P  P  T    + GLA P        P   PP P+       P+  PTT 
Sbjct: 1186 -LATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTP 1244

Query: 541  GS-----EGAGAAPCP---PNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPT 592
             +     +G  A P P   P P  +  P L  GG   PP       +  +  S + G  T
Sbjct: 1245 AATPPSPKGGPATPPPKGAPTPPAATPPSLK-GGLATPPHKGAPNPAVVTPPSPKGGPAT 1303

Query: 593  LPPKGLAGPPA--------SPGKAQP---PKPERVTSLRSPGASVSSSLTSLCSSSSDPA 641
             PPKG   PPA        SPG   P   P P  VT   SP  + +   T+  S      
Sbjct: 1304 SPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTP-PSPKGTPTLPATTPSSKGGPTT 1362

Query: 642  PSDRSGPQ--ILTPL--GDRFVIPPHPK----VPAPFSPPPSK---PRSPN--PAAPALA 688
            PS + GP     TP   G   + PP PK    +P+P   P S    P SP   PA P   
Sbjct: 1363 PSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTR 1422

Query: 689  APAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSP------------PPS 736
              A  P   S  D +P     P  T   L+++P  S  +  P +P            PPS
Sbjct: 1423 EGAATP---SKGDLTP-----PAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPS 1474

Query: 737  YHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMAD---------- 786
              P  PP  K      +P  +     P+  P  P   P +P+E   + +           
Sbjct: 1475 --PKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTAT 1532

Query: 787  -------------------------------FPPPEEAFFSVASPEPAGP--------SG 807
                                            P P+EA  + +S E + P         G
Sbjct: 1533 LLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKG 1592

Query: 808  SP---ELVSSPAASSSSATALQIQP---PGSPDPPPAPPAPAPASSAPGHVAKLPQKEP- 860
            +P   EL+  PA +S S       P   P SP+  PA PAP    ++P       +  P 
Sbjct: 1593 APSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPT 1652

Query: 861  ----VGCSKGGGPPREDVGAPLVT-PSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRA 915
                V C  G   P+   G P    P+ L+ V +    AP    TP +     + P  + 
Sbjct: 1653 SPASVTCKMGATVPQASKGLPAKKGPTALKEVLV----APAPESTPIITAPTRKGPQTKK 1708

Query: 916  LSGRASPV-PAPSSGLHAAVRLKACSLA--------ASEGLSSAQPNGPPEAEPRPPQSP 966
             S  + P+ P PS+   +   L   + A        +S+       +  P+    PP+S 
Sbjct: 1709 SSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESK 1768

Query: 967  ASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVA 1026
            AST                   P T A  ++ ++ +  S S    P  P   P AP PV 
Sbjct: 1769 AST-------------------PLTAAAFEK-VLPKPESASVSAAPSPPVSLPLAPSPVP 1808

Query: 1027 RKPSVGVPPPASPSYPRAEP 1046
              P      P+SP      P
Sbjct: 1809 TLPPKQQFLPSSPGLVLESP 1828



 Score =  105 bits (262), Expect = 2e-22
 Identities = 161/666 (24%), Positives = 220/666 (33%), Gaps = 121/666 (18%)

Query: 433  SSKGGSEGQPESSTASNSVVPPP--QGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVS 490
            S KGG    P     + +VV PP  +GG     P G  T  A+   S + S         
Sbjct: 1273 SLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGT------ 1326

Query: 491  LRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPR--PPTTGG----SEG 544
                    PPP+            P  P   PP P  K  P LP   P + GG    S  
Sbjct: 1327 --------PPPK----------GAPTPPAVTPPSP--KGTPTLPATTPSSKGGPTTPSSK 1366

Query: 545  AGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPAS 604
             G  P    P++   P ++P   +R P  P    SP    +S +  P  P K  A P   
Sbjct: 1367 EGPTPPAATPSHKGGPAMTPPSPKRGPAIP----SPKGDPTSPAVIPLSPKKAPATPVTR 1422

Query: 605  PGKAQPPK----PERVTSL---RSPGASVSSSLTSLCSSSSDPA------PSDRSGP--- 648
             G A P K    P  VT +   ++P  S      +  SS  DP       PS +  P   
Sbjct: 1423 EGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPK 1482

Query: 649  QILTPLGDRFVIPPHPKVPAPF----------SPPPSKPRSPNPAAPALAAPAVVPGPVS 698
            Q+ T    +      P  PAP           S P   P +P+     +A  A +    +
Sbjct: 1483 QVATSSSPKKA----PATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKT 1538

Query: 699  TTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASE 758
                +P+    P     P  +           P+ P S     PP   P     APS  E
Sbjct: 1539 PATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKE 1598

Query: 759  -------TAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPEL 811
                   T+  P + P  P   PP+PE+                  A+P P G   SP +
Sbjct: 1599 LLIPPAVTSPSPKEAPTPPAVTPPSPEK----------------GPATPAPKGTPTSPPV 1642

Query: 812  VSSPAASSSSATALQIQPPGSPDPPPAPPAPA---PASSAPGHVAKLPQKEPV---GCSK 865
              S    S ++ A      G+  P  +   PA   P +     VA  P+  P+      K
Sbjct: 1643 TPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRK 1702

Query: 866  GGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAP-QKPLRRALSGR----- 919
            G    +    +P + P           G+ G   T A  P  P QK   +   G+     
Sbjct: 1703 GPQTKKSSATSPPICPD-----PSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHS 1757

Query: 920  -----ASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIF 974
                 A P    S+ L AA   K      S  +S+A P+ P      P   P       F
Sbjct: 1758 PKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAA-PSPPVSLPLAPSPVPTLPPKQQF 1816

Query: 975  SKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQ--APKKSPKAPPPVARKPSVG 1032
               S  L LE P  P   AD       EL  +    P     P +S     P  +   + 
Sbjct: 1817 LPSSPGLVLESPSKPLAPADED-----ELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIP 1871

Query: 1033 VPPPAS 1038
            VP P++
Sbjct: 1872 VPTPSA 1877



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 179/793 (22%), Positives = 272/793 (34%), Gaps = 112/793 (14%)

Query: 309  STGTRAPPLTRPM--SLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDV 366
            S G+   PL +    S+ + G TG +  ++P    +S+   +T  S     +V+PP    
Sbjct: 304  SLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPS- 362

Query: 367  VALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIV 426
                R  +   +  +    +P+  +     SS++     S + ++S   +S S ++  I+
Sbjct: 363  ----RNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATS---FSLSPTTSLIL 415

Query: 427  SDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSI-RSSGQLS 485
                  +       Q   S+   + +      +   +P+  +T E +  +S   SSG +S
Sbjct: 416  KSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPT--TTFEVATCVSPPMSSGPIS 473

Query: 486  G-RSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQ--LPRPPTT--- 539
                 S   L   P  P+   +     L +P  P  LP   + K  P   L + PT    
Sbjct: 474  NIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSP-PLPDPEDLKNLPSSVLVKFPTQKDL 532

Query: 540  ----GGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPP 595
                   EGA  +P          P + P     P  SP    + SS     S   TL  
Sbjct: 533  QTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAK 592

Query: 596  KGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGP----QIL 651
            K L G P   GK         +S+ SP    SS+      S + P   D +GP     ++
Sbjct: 593  KSL-GEPLPIGKP-------ASSMTSPLGVNSSASVIKTDSYAGP---DSAGPLLKSSLI 641

Query: 652  TPLGDRFVIPPHPKVPAPFSPPPSKPRSP--NPAAPALAAPAVVPGPVSTTDASPQSPPT 709
            TP    F  P     PA  +P  +K  S     A+P L           T   +P++ P 
Sbjct: 642  TPTVAAF--PLESADPAGVAPTTAKGTSTYTTTASPFLEG---------TVSLAPKNHPV 690

Query: 710  PQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNW 769
             + TLT L   P  S++    PSP  +  P       PE+    PS       P   P  
Sbjct: 691  KEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPS-------PSLPPAG 743

Query: 770  PPP--------------------PPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSP 809
             PP                    P   P E   + A         +   SP P G S SP
Sbjct: 744  TPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSP 803

Query: 810  ELVSSPAASSSSATALQIQPPGSPDPP----PAPPAPAPASSAPGHVAKLPQKEPVGCSK 865
            +    P    S+           PD P     +P +P  AS  P +       +    + 
Sbjct: 804  QTKRPPTKKGSA----------GPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATT 853

Query: 866  GGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPA 925
                P    GAP  TPS +  +  + V  P   P     PS    P  +      +P  A
Sbjct: 854  HSPTPPSPKGAP--TPSAVTPLSPKGVTLP---PKETPTPSVVNLPFPKEGPATPAPKQA 908

Query: 926  PSSGLHAAVRLKACSLAASEGL-SSAQPNG---PPEAEPRPPQSPASTASFIFSKGSRKL 981
            P+  + ++   KA +  A +G+ +S  P G   PP A P  P+   +T S  ++      
Sbjct: 909  PALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWA------ 962

Query: 982  QLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSY 1041
                P  P       +   A         PP A   SPK  P          PP  +P  
Sbjct: 963  ----PTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPS 1018

Query: 1042 PRAEPLTAPPTNG 1054
            P+  P   P   G
Sbjct: 1019 PKGSPAATPFPKG 1031



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 115/506 (22%), Positives = 169/506 (33%), Gaps = 97/506 (19%)

Query: 316  PLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIP------HAVLPPTVDVVAL 369
            P+  P   AV   +    PA P S    I+P AT LSK  P       A++PP + V   
Sbjct: 1499 PMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVP-- 1556

Query: 370  GRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDG 429
               S +          +PA+  S       SSP      P+ +  T+  + S   ++   
Sbjct: 1557 ---SPKKTPAIPTPKEAPATPSS----KEASSP------PAVTPSTYKGAPSPKELLIPP 1603

Query: 430  STLSSKGGSEGQPESSTASNSVVPP-PQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRS 488
            +  S        P+ +    +V PP P+ G    +P G  T+      S++ S       
Sbjct: 1604 AVTSPS------PKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDS------- 1650

Query: 489  VSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPK------------PERKQQPQLPRP 536
                    P  P   T  +   G  VP    GLP K            P  +  P +  P
Sbjct: 1651 --------PTSPASVTCKM---GATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAP 1699

Query: 537  PTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPK 596
               G      +A  PP   +      S G       +P   +   S  +++    +  PK
Sbjct: 1700 TRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPK 1759

Query: 597  GLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGD 656
            G   PP S  KA  P            A+    L    S+S   APS    P +  PL  
Sbjct: 1760 GPLAPPES--KASTPLT---------AAAFEKVLPKPESASVSAAPS----PPVSLPLA- 1803

Query: 657  RFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTP 716
                 P P VP   + PP +   P+     L +P+    P    +  P  PP P +   P
Sbjct: 1804 -----PSP-VP---TLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVP 1854

Query: 717  LQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPA 776
             Q   V        P+P  +  P P P+ K  V      +   ++             P 
Sbjct: 1855 FQSVLV------NMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDS--------DESVPE 1900

Query: 777  PEEQDLSMADFPPPEEAFFSVASPEP 802
             EEQD + A     + A  +    EP
Sbjct: 1901 LEEQDSTQATTQQAQLAAAAEIDEEP 1926



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 137/607 (22%), Positives = 196/607 (32%), Gaps = 135/607 (22%)

Query: 531  PQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGT 590
            P LP P +    +      CP + AN   P  SP      P       S SSG +   GT
Sbjct: 43   PTLPPPCSPAPQQ------CPLSAANQASPFPSPSTIASTPLEVPFPQS-SSGTALPLGT 95

Query: 591  ----PTLPPKGLAGPPASPGKAQPPKPERVTSLR-SPGASVSSSLTSLC-----SSSSDP 640
                PT  P  L GPP SP       P    +L+ +P +S   +L +L       SS+ P
Sbjct: 96   APEAPTFLPN-LIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFP 154

Query: 641  APSDRSGPQILTPLGDRFVI------PPHPK-----VPAPFSPPPSKPRSP--------- 680
                 S P +        +       P  PK     VP+   P P    SP         
Sbjct: 155  PNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPY 214

Query: 681  ---NPAAP-----------------ALAAPAVVPGPVSTTDASPQSPPT---------PQ 711
                P A                  A+A+P V    +S+   SPQ+P +         P 
Sbjct: 215  HCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPA 274

Query: 712  TTLTPLQESPVISKDQ-SPPPSPPPSY-----------------------HPPPPPTKKP 747
                  Q  PV++  Q +  P+ PP +                          P     P
Sbjct: 275  ALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDP 334

Query: 748  EV-VVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPE-PAGP 805
             V  +    +S  A  P Q    PP P         S  +  P   A F V +P    GP
Sbjct: 335  TVKTISVDHSSTGASYPSQRSVIPPLP---------SRNEVVPATVAAFPVVAPSVDKGP 385

Query: 806  SGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPA----PAPASSAPGHVAKLPQKEPV 861
            S    +  SP+ S + AT+  + P  S     +P A    P  A      V   P     
Sbjct: 386  STISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTN 445

Query: 862  GCSKGGGPPREDVGAPLVTPSL----LQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALS 917
             C+    P      A  V+P +    +  +   S  A   AP     PS       R   
Sbjct: 446  PCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPV 505

Query: 918  GRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGP-------------PEAEPRPPQ 964
                P P     L ++V +K  +    + + ++    P             P   P    
Sbjct: 506  SPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQA 565

Query: 965  SPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPP 1024
            +P ++ SF  +  S ++    P+SPE  A L +      +S+ E  P   P  S  +P  
Sbjct: 566  APKNSPSFQSTSSSPEI----PLSPE--ATLAK------KSLGEPLPIGKPASSMTSPLG 613

Query: 1025 VARKPSV 1031
            V    SV
Sbjct: 614  VNSSASV 620



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 69/301 (22%), Positives = 101/301 (33%), Gaps = 23/301 (7%)

Query: 734  PPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEA 793
            P +    P P  +  V+  + + S TA      P  PPP  PAP++  LS A+   P   
Sbjct: 10   PATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASP--- 66

Query: 794  FFSVASPEPAGPSGSPELVSSPAASSSSATALQIQP------PGSPDPPPAPPAPAPASS 847
                  P P+  + +P  V  P +SS +A  L   P      P    PP +P A A AS 
Sbjct: 67   -----FPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASP 121

Query: 848  APGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPT--PALGP 905
                  K         +     P     +    P+LL      +V   G   T    + P
Sbjct: 122  MIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAP 181

Query: 906  SAPQKPLRRALS-------GRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEA 958
            S P+  L +  S       G  SP    S+  +  V   A   +    L    P      
Sbjct: 182  SEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAI 241

Query: 959  EPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKS 1018
                 +    ++  I  +    L L+ PVSP     L    +  + S  +   P  P   
Sbjct: 242  ASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDF 301

Query: 1019 P 1019
            P
Sbjct: 302  P 302



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 90/401 (22%), Positives = 134/401 (33%), Gaps = 67/401 (16%)

Query: 680  PNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHP 739
            P P  P   +PA    P+S  + +   P       TPL+    +   QS   +  P    
Sbjct: 41   PGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLE----VPFPQSSSGTALPLGTA 96

Query: 740  PPPPTKKPEVVVEAPSASETA-EEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFS-- 796
            P  PT  P ++    S +  A   P+  P     P  +     +++A     + + F   
Sbjct: 97   PEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPN 156

Query: 797  -VASPE--PAGPSGSPELVSSPAASSSSATALQIQPPG-SPDPPPAPPAPAPASSAPGH- 851
             + SP       SGS   +S+P A S   T L   P    P+P   P  P   S+ P H 
Sbjct: 157  LLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHC 216

Query: 852  ----------VAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTP 901
                      VA LPQ  P             + +P V  + +  V +            
Sbjct: 217  VTPMASIQSGVASLPQTTPTTTLA--------IASPQVKDTTISSVLI------------ 256

Query: 902  ALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPR 961
                 +PQ P   +L G  SP         AA+ L   SL     ++S+Q    P   P 
Sbjct: 257  -----SPQNPGSLSLKGPVSP--------PAALSLSTQSLPV---VTSSQKTAGPNTPPD 300

Query: 962  PPQSPASTASFIFSKGSRKLQLERPVSPETQAD-LQRNLVAELRSISEQRP------PQA 1014
             P S  S  + +       +QL     P   +D   + +  +  S     P      P  
Sbjct: 301  FPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPL 360

Query: 1015 PKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGL 1055
            P ++   P  VA  P V       PS      +T  P+  L
Sbjct: 361  PSRNEVVPATVAAFPVVAPSVDKGPS--TISSITCSPSGSL 399



 Score = 34.7 bits (78), Expect = 0.51
 Identities = 62/287 (21%), Positives = 95/287 (33%), Gaps = 46/287 (16%)

Query: 308  RSTGTRAPPLTRPMSLAVP----GLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPT 363
            + + T    +T  M   VP    GL    GP       ++ +P++T +       +  PT
Sbjct: 1648 KDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPI-------ITAPT 1700

Query: 364  VDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSD 423
                   + S  +   C   SA   S   L    S  +P P       SS T   ++  D
Sbjct: 1701 RKGPQTKKSSATSPPICPDPSAKNGSKGPL----STVAPAPLLPVQKDSSKT---AKGKD 1753

Query: 424  TIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQ 483
               S    L+        P ++ A   V+P P+  S   +PS                  
Sbjct: 1754 ASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSP----------------- 1796

Query: 484  LSGRSVSLRKLKRPPP--PPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGG 541
                 VSL     P P  PP++       GL +      L P  E +  P +P  P +GG
Sbjct: 1797 ----PVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGG 1852

Query: 542  SEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQS 588
                      P P ++ +P  +P       + P    +  SG  S S
Sbjct: 1853 VPFQSVLVNMPTPKSAGIPVPTPSA-----KQPVTKNNKGSGTESDS 1894



 Score = 32.3 bits (72), Expect = 2.5
 Identities = 33/132 (25%), Positives = 45/132 (34%), Gaps = 18/132 (13%)

Query: 926  PSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLER 985
            P      AV   + +L+ +  L    P  PP   P P Q P S A+          Q   
Sbjct: 17   PQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAAN----------QASP 66

Query: 986  PVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPS-YPRA 1044
              SP T A     +     S     P     ++P   P +       + PP SP+    A
Sbjct: 67   FPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNL-------IGPPISPAALALA 119

Query: 1045 EPLTAPPTNGLP 1056
             P+ AP   G P
Sbjct: 120  SPMIAPTLKGTP 131


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score =  129 bits (325), Expect = 1e-29
 Identities = 172/695 (24%), Positives = 249/695 (35%), Gaps = 116/695 (16%)

Query: 410  SSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGST 469
            SSS  + S S S     S+ S  S  G S+ QP     S S+V      + +     G+ 
Sbjct: 531  SSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKR----GTQ 586

Query: 470  AEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQ 529
             E S    + S   ++    SL     P P     ++  Q    +P  P   PP P    
Sbjct: 587  LEESSKARMES---MNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPP---PPPPPPPP 640

Query: 530  QPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLS-----PGGSRRPPRSPERTLSPSSGY 584
             P  P PP    S  +  +  P     S +  L       G   +PP  P          
Sbjct: 641  PPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVM-------- 692

Query: 585  SSQSGTPTL--PPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSS----- 637
             SQS  P +  PP G+  PP  P    PP P       +PG++++    + C+ S     
Sbjct: 693  QSQSVKPQILVPPNGVVPPPPPP----PPPP-------TPGSAMAQLKPAPCAPSLPQFS 741

Query: 638  SDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPV 697
            + P P      Q +T +      PP P +PAP   PP  P  P            +P P 
Sbjct: 742  APPPPLKIHQVQHITQVAPP-TPPPPPPIPAPL--PPQAPPKPL---------VTIPAPT 789

Query: 698  STTDASP----QSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEA 753
            ST   +P     +PPTP   + P ++ P       PP  P P    PPP   K +     
Sbjct: 790  STKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAK 849

Query: 754  PSASETAEEP-----LQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGS 808
            P  S  +  P     +     PPP PPA E Q L         ++  +V +     PS  
Sbjct: 850  PPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSI 909

Query: 809  PELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAP-GHVAKLPQKEPVGCSKGG 867
            P  V SP        +  + PP  P P PAPP P P +++P    +  P K+    S  G
Sbjct: 910  P--VPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPG 967

Query: 868  G---PPREDVGAPLVT-----------PSLLQMVRLRSVGAPGGAPTPAL--GPSAPQKP 911
            G   PP     + + +           PS+  +V   +  A  G+P+      P+AP KP
Sbjct: 968  GKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKP 1027

Query: 912  LRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTAS 971
             +  LSG    V  P       V  KA  L+     S  +   PP     PP  P     
Sbjct: 1028 GKLNLSG----VNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPP----- 1078

Query: 972  FIFSKGSRKLQLERPVSP-ETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPP------ 1024
                      + E P+ P E  A    N   ++  ++ Q    +     KAPPP      
Sbjct: 1079 ----------ETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRN 1128

Query: 1025 ---------VARKPSVGVPPPASPSYPRAEPLTAP 1050
                     ++ +P++    P  P+ P++     P
Sbjct: 1129 DSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQP 1163



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 117/457 (25%), Positives = 164/457 (35%), Gaps = 94/457 (20%)

Query: 617  TSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSK 676
            TSL S      SS +S+  S S+ +    SG     P G    +     V + FS    +
Sbjct: 527  TSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGH---VRSQSIVSSVFSEAWKR 583

Query: 677  PRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPS 736
                  ++ A       P        SPQ  P   T  T  Q SP +     PPP PPP 
Sbjct: 584  GTQLEESSKARMESMNRPYTSLVPPLSPQ--PKIVTPYTASQPSPPLPP---PPPPPPP- 637

Query: 737  YHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFS 796
              PPPPP                          PPPPPP P +   S     P    + +
Sbjct: 638  --PPPPP--------------------------PPPPPPLPSQSAPSAGSAAPMFVKYST 669

Query: 797  VASPEPAGP-SGSPELVSSPAASSSSATALQIQPPGS---PDPPPAPPAPAPASSAPGHV 852
            +   + A   SG+     +P    S +   QI  P +   P PPP PP P P S+     
Sbjct: 670  ITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSA----- 724

Query: 853  AKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPA----LGPSAP 908
              + Q +P  C+    P      AP     + Q+  +  V  P   P P     L P AP
Sbjct: 725  --MAQLKPAPCA----PSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAP 778

Query: 909  QKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPAS 968
             KPL          +PAP+S           +   +  ++ A P  P    P   + PA 
Sbjct: 779  PKPL--------VTIPAPTS-----------TKTVAPVVTQAAPPTPTPPVPPAKKQPAF 819

Query: 969  TASFIFSKGSRKLQLERPVSPETQ-ADLQRNLVAELRSISEQRPPQAPKKSPKAP-PPVA 1026
             AS+I            P SP T    +    + + +S   + PP     SP +P P V 
Sbjct: 820  PASYI------------PPSPPTPPVPVPPPTLPKQQSFCAKPPP-----SPLSPVPSVV 862

Query: 1027 RKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTK 1063
            ++ +   PPP +P    ++PL   P N  P +    K
Sbjct: 863  KQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVK 899



 Score = 30.8 bits (68), Expect = 7.3
 Identities = 17/59 (28%), Positives = 27/59 (45%)

Query: 3   ARAPPAAPAAEEPGNPGGPPRRKKSRSGASGLRRAFSWLRGKRRKKKAAGAEGAEPAAP 61
           A  PP  P A    +  G P +K S++ + G ++     +     K ++GAE  EP  P
Sbjct: 937 APPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRP 995


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score =  126 bits (317), Expect = 1e-28
 Identities = 156/567 (27%), Positives = 189/567 (33%), Gaps = 98/567 (17%)

Query: 446  TASNSVVPPPQG---GSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPR 502
            T S S  PPP      +G+G P        S          +S    +   +  PPP P 
Sbjct: 804  TQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPC 863

Query: 503  RTHSLHQRGLA-VPDGPLGLPPKP-ERKQQPQLPRPPTTGGSE----------GAGAAPC 550
               S    GL  VP  P  LP           +P+PP   G+E          GAG  P 
Sbjct: 864  TESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPP 923

Query: 551  PPNPANSWVP--GLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKA 608
            PP P    +P   L   G   PP  P   + P          P LP  G+  PP  PG  
Sbjct: 924  PPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPP---------PPLPGAGIPLPPPLPGAG 974

Query: 609  QPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPA 668
             PP P        PGA +        +    P P   +G     PL    + PP P   A
Sbjct: 975  IPPPPPL------PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA 1028

Query: 669  PFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQS 728
               PPP  P +  P  P L    + P P       P  PP P   + P    P+      
Sbjct: 1029 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP--PPPLPGAGIP 1086

Query: 729  PPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFP 788
            PPP  P +  PPPPP   P V +  P        PL     PPPPP       L  A  P
Sbjct: 1087 PPPPLPGAGIPPPPPL--PGVGIPPPP-------PLPGAGIPPPPP-------LPGAGIP 1130

Query: 789  PPEEAFFSVASPEPAGPS-GSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASS 847
            PP     +   P P  P  G P     P A       L    PG+  PPP PP P     
Sbjct: 1131 PPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPL----PGAGIPPP-PPLPGVGIP 1185

Query: 848  APGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALG-PS 906
             P                   PP   VG P   P       L   G P   P P +G P 
Sbjct: 1186 PP-------------------PPLPGVGIPPPPP-------LPGAGIPPPPPLPGMGIPP 1219

Query: 907  APQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSP 966
            AP           A P+P P +G+     L          + S+    P      PP  P
Sbjct: 1220 AP-----------APPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLP 1268

Query: 967  ASTASFIFS--KGSRKLQLE--RPVSP 989
            +       +  KGSRK  +E  RP+ P
Sbjct: 1269 SGLFGLGMNQDKGSRKQPIEPCRPMKP 1295



 Score =  125 bits (315), Expect = 2e-28
 Identities = 157/567 (27%), Positives = 190/567 (33%), Gaps = 96/567 (16%)

Query: 323  LAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCSLRTLSRCSL 382
            L +P + G  G   P  P     PQ  + S++           +V+  R S++  S    
Sbjct: 755  LTLPPVDGLPG-RPPCPPGAESGPQTKFCSEISL---------IVSPRRISVQLDSHQPT 804

Query: 383  HSAS-PASVRSLGRFSSVSSPQPRSRHPSSSSDTW--SHSQSSDTIVSDGSTLSSKGGSE 439
             S S P    SL    S    QP S+ P S S  +  SH  S  +   +   + S     
Sbjct: 805  QSISQPPPPPSL--LWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862

Query: 440  GQPESSTASN-SVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPP 498
                SS+     +VPPP        P  G T     + +I     L G  +       PP
Sbjct: 863  CTESSSSMPGLGMVPPPP------PPLPGMTVPTLPSTAIPQPPPLQGTEML------PP 910

Query: 499  PPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSW 558
            PPP             P    G+PP P       LP PP  G    AG  P PP P  + 
Sbjct: 911  PPP-------------PLPGAGIPPPPPLPGAGILPLPPLPG----AGIPPPPPLPGAAI 953

Query: 559  VPG--LSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERV 616
             P   L   G   PP  P   + P          P LP  G+  PP  PG   PP P   
Sbjct: 954  PPPPPLPGAGIPLPPPLPGAGIPPP---------PPLPGAGIPPPPPLPGAGIPPPPPL- 1003

Query: 617  TSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSK 676
                 PGA +        +    P P   +G     PL    + PP P   A   PPP  
Sbjct: 1004 -----PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1058

Query: 677  PRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPS 736
            P +  P  P L    + P P       P  PP P   + P    P +     PPP P P 
Sbjct: 1059 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVG---IPPPPPLPG 1115

Query: 737  YHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPP----PAPEEQDLSMADFPPPEE 792
               PPPP          P A      PL     PPPPP      P    L  A  PPP  
Sbjct: 1116 AGIPPPPP--------LPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPP 1167

Query: 793  AFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPP----GSPDPPPAP-----PAPA 843
               +   P P  P      V  P         +   PP    G P PPP P     PAPA
Sbjct: 1168 LPGAGIPPPPPLPG-----VGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPA 1222

Query: 844  PASSAPGHVAKLPQKEPVGCSKGGGPP 870
            P    PG     P   PV      GPP
Sbjct: 1223 PPLPPPGTGIPPPPLLPV-----SGPP 1244



 Score =  106 bits (265), Expect = 1e-22
 Identities = 159/620 (25%), Positives = 194/620 (31%), Gaps = 158/620 (25%)

Query: 452  VPPPQGGSGR-----GSPSGGSTAEASDTLSIRSSGQLSGRSVS---LRKLKRPPPPPRR 503
            +PP  G  GR     G+ SG  T   S+   I S  ++S +  S    + + +PPPPP  
Sbjct: 757  LPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSL 816

Query: 504  THSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLS 563
              S  Q        P   PP     +         +   + +   P PP    +      
Sbjct: 817  LWSAGQ------GQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSM 870

Query: 564  PGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQ-PPKPERVTSLRSP 622
            PG    PP  P     P  G +     PTLP   +  PP   G    PP P  +     P
Sbjct: 871  PGLGMVPPPPP-----PLPGMT----VPTLPSTAIPQPPPLQGTEMLPPPPPPL-----P 916

Query: 623  GASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNP 682
            GA +             P P   +G   L PL    + PP P   A   PPP  P +  P
Sbjct: 917  GAGIPP-----------PPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIP 965

Query: 683  AAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPP 742
              P L    + P P       P  PP P   + P    P+      PPP  P +  PPPP
Sbjct: 966  LPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPPPP 1023

Query: 743  PTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEP 802
            P          P A      PL     PPPPP       L  A  PPP           P
Sbjct: 1024 PL---------PGAGIPPPPPLPGAGIPPPPP-------LPGAGIPPPP----------P 1057

Query: 803  AGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSA-PGHVAKLPQKEPV 861
               +G P     P A             G P PPP P A  P     PG  A +P   P+
Sbjct: 1058 LPGAGIPPPPPLPGA-------------GIPPPPPLPGAGIPPPPPLPG--AGIPPPPPL 1102

Query: 862  -GCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRA 920
             G      PP    G P   P       L   G P   P P  G   P  PL R   G  
Sbjct: 1103 PGVGIPPPPPLPGAGIPPPPP-------LPGAGIPPPPPLPGAG-IPPPPPLPRV--GIP 1152

Query: 921  SPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRK 980
             P P P +G+                             P PP  P +            
Sbjct: 1153 PPPPLPGAGI-----------------------------PPPPPLPGAGIP--------- 1174

Query: 981  LQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPAS-P 1039
                 P  P             L  +    PP  P      PPP+   P  G+PPP   P
Sbjct: 1175 -----PPPP-------------LPGVGIPPPPPLPGVGIPPPPPL---PGAGIPPPPPLP 1213

Query: 1040 SY---PRAEPLTAPPTNGLP 1056
                 P   P   PP  G+P
Sbjct: 1214 GMGIPPAPAPPLPPPGTGIP 1233



 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 120/432 (27%), Positives = 144/432 (33%), Gaps = 76/432 (17%)

Query: 431  TLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSG-----QLS 485
            TL S    +  P   T      PPP  G+G   P     A       +  +G      L 
Sbjct: 890  TLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLP 949

Query: 486  GRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPL---GLPPKPERKQQPQLPRPPTTGGS 542
            G ++       PPPPP     L   G+ +P  PL   G+PP P        P PP  G  
Sbjct: 950  GAAI-------PPPPP-----LPGAGIPLPP-PLPGAGIPPPPPLPGAGIPPPPPLPGAG 996

Query: 543  -------EGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPP 595
                    GAG  P PP P     P     G+  PP  P     P +G       P LP 
Sbjct: 997  IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP----LPGAGIPPP---PPLPG 1049

Query: 596  KGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLG 655
             G+  PP  PG   PP P        PGA +        +    P P   +G     PL 
Sbjct: 1050 AGIPPPPPLPGAGIPPPPPL------PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1103

Query: 656  DRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLT 715
               + PP P   A   PPP  P +  P  P L    + P P       P  PP P   + 
Sbjct: 1104 GVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIP 1163

Query: 716  P--------LQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDP 767
            P        +   P +     PPP P P    PPPP          P A      PL  P
Sbjct: 1164 PPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPP--------PLPGAGIPPPPPL--P 1213

Query: 768  NWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQI 827
                PP PAP          PPP         P P  P   P L+  P   SS+    Q+
Sbjct: 1214 GMGIPPAPAP--------PLPPPGTGI----PPPPLLPVSGPPLL--PQVGSSTLPTPQV 1259

Query: 828  QPPGSPDPPPAP 839
                   PPP P
Sbjct: 1260 ---CGFLPPPLP 1268



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 100/354 (28%), Positives = 120/354 (33%), Gaps = 42/354 (11%)

Query: 440  GQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVS----LRKLK 495
            G P       + +PPP    G G P       A     I     L G  +     L    
Sbjct: 941  GIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAG----IPPPPPLPGAGIPPPPPLPGAG 996

Query: 496  RPPPPPRRTHSLHQRGLAVPDGP----LGLPPKPERKQQPQLPRPPTTGGS-------EG 544
             PPPPP         G  +P  P     G+PP P        P PP  G          G
Sbjct: 997  IPPPPPLP-------GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1049

Query: 545  AGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPAS 604
            AG  P PP P     P     G+  PP  P     P +G       P LP  G+  PP  
Sbjct: 1050 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPP----LPGAGIPPP---PPLPGAGIPPPPPL 1102

Query: 605  PGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHP 664
            PG   PP P        PGA +        +    P P   +G     PL  R  IPP P
Sbjct: 1103 PGVGIPPPPPL------PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL-PRVGIPPPP 1155

Query: 665  KVP-APFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVI 723
             +P A   PPP  P +  P  P L    + P P       P  PP P   + P    P +
Sbjct: 1156 PLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGM 1215

Query: 724  SKDQSP-PPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPA 776
                +P PP PPP    PPPP          P    +     Q   + PPP P+
Sbjct: 1216 GIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPS 1269



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 90/348 (25%), Positives = 124/348 (35%), Gaps = 56/348 (16%)

Query: 641 APSDRSGPQILTPLG-DRFVIPPHPKV-PAPFSPPPSKPRSPNPAAPALAAPAVVPGPVS 698
           AP     PQ    LG DRF++ P      AP SP   +         AL+A + +P  ++
Sbjct: 234 APPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQ---------ALSALSDLPESLA 284

Query: 699 TTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAP--SA 756
                PQ PP+P     P+ E+P +   Q      P S   P P     E    AP   A
Sbjct: 285 AEPREPQQPPSPGG--LPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGA 342

Query: 757 SETAEEPLQD-----PNWPPPPPPAPE-EQDLSMADFPPPEEAFFSVASPEPAGPSGSPE 810
            +T EE  +D     P   P    APE  +D        PEE        E  GP  +P 
Sbjct: 343 GDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEE--------EAQGPD-APA 393

Query: 811 LVSSPAASSSSATALQIQPPGSP------DPPPAPPAPAPASSAPGHVAKLPQKEPVGCS 864
             S P + + S    +  P  +P          + P  +P S +P    ++ ++     S
Sbjct: 394 AASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSP-SQSPNQSPRIKRRPEPSLS 452

Query: 865 KGGGPPREDVGAPLVTPS-----LLQMVRLRSVGAPGGAPTPALGPSA----------PQ 909
           +G       V AP             + R        GA TP +G SA            
Sbjct: 453 RGSRTALASVAAPAKKHRADGGLAAGLSRSADWTEELGARTPRVGGSAHLLERGVASDSG 512

Query: 910 KPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPE 957
             +  AL+ +AS  PA + G               E L S Q NGPPE
Sbjct: 513 GGVSPALAAKASGAPAAADGFQNVF----TGRTLLEKLFSQQENGPPE 556


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score =  122 bits (306), Expect = 2e-27
 Identities = 119/412 (28%), Positives = 143/412 (34%), Gaps = 78/412 (18%)

Query: 493 KLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPP 552
           K + PP PP +      +G   P GP   PP P + Q P     P  GG++  G  P   
Sbjct: 46  KPQGPPSPPGKPQGPPPQGGNQPQGP---PPPPGKPQGP-----PPQGGNKPQGPPP--- 94

Query: 553 NPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPK 612
                      PG  + PP   +++ SP S      G P        GPP  PGK Q P 
Sbjct: 95  -----------PGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP 143

Query: 613 PERVTSLRSP------------GASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVI 660
           P+     + P            G + S S  S       P P   + PQ   P       
Sbjct: 144 PQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPP------P 197

Query: 661 PPHPKVPAPFS-------PPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTT 713
           P  P+ P P         PPP KP+ P P     +  A  P         PQ PP PQ  
Sbjct: 198 PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSP------PGKPQGPP-PQGG 250

Query: 714 LTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPP- 772
             P    P   K Q PPP        PPPP K      +  S S ++  P   P  PPP 
Sbjct: 251 NQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQ 310

Query: 773 -------PPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATAL 825
                  PPP P          PPP+        P P  P G P     P   S S +A 
Sbjct: 311 GGNQPQGPPPPP-----GKPQGPPPQGGNKPQGPPPPGKPQGPP-----PQGGSKSRSAR 360

Query: 826 QIQPPGSPDPPPAPPAPAPASSAP--GHVAKLPQKEPVGCSKGGGPPREDVG 875
              PPG P  PP      P    P  G   + PQ  P G  +  GPPR   G
Sbjct: 361 --SPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAG--QPQGPPRPPQG 408



 Score =  113 bits (282), Expect = 1e-24
 Identities = 122/471 (25%), Positives = 145/471 (30%), Gaps = 109/471 (23%)

Query: 579  SPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSS 638
            SPS    +  G P        GPP+ PGK Q P P+     + P                
Sbjct: 28   SPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGP---------------- 71

Query: 639  DPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVS 698
             P P    GP            PP         PPP KP+ P P      +P   PG   
Sbjct: 72   PPPPGKPQGP------------PPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPG--- 116

Query: 699  TTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASE 758
                 PQ PP PQ    P    P   K Q PPP        PPPP K      +  + S 
Sbjct: 117  ----KPQGPP-PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSR 171

Query: 759  TAEEPLQDPNWPPP--------PPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPE 810
            ++  P   P  PPP        PPP P +        PPP+        P P  P G P 
Sbjct: 172  SSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ-----GPPPQGGNKPQGPPPPGKPQGPPP 226

Query: 811  LVSSPAASSSSATALQIQPPGSPDPPPA---------PPAPAPASSAPGHVAKLPQKEPV 861
               + + S+ S       PPG P  PP          PP P      P      PQ  P 
Sbjct: 227  QGDNKSQSARS-------PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPP 279

Query: 862  GCSKGGGPP---------REDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPL 912
                 G PP         R   G P   P             P G   P   P  P KP 
Sbjct: 280  PGKPQGPPPQGGSKSRSSRSPPGKPQGPP-------------PQGGNQPQGPPPPPGKPQ 326

Query: 913  RRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASF 972
                 G   P   P  G       +  S + S      +P GPP+ E   PQ P   A  
Sbjct: 327  GPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPA-- 384

Query: 973  IFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPP 1023
                G    Q + P + + Q                 RPPQ  +  P  PP
Sbjct: 385  ----GGNPQQPQAPPAGQPQ--------------GPPRPPQGGR--PSRPP 415



 Score = 90.5 bits (223), Expect = 8e-18
 Identities = 95/354 (26%), Positives = 128/354 (36%), Gaps = 46/354 (12%)

Query: 435 KGGSEGQPESSTASNSVVPPPQGGSGRGSPSG-----GSTAEASDTLSIRSS-GQLSGRS 488
           +GG++ Q           PPPQGG+    P       G   +   + S RS  G+  G  
Sbjct: 63  QGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPP 122

Query: 489 VSL-RKLKRPPPPPRRTHSLHQRGLAVPDGP------LGLPPKPERKQQ-----PQLPR- 535
                + + PPPPP +      +G   P GP       G PP+ + K +     P  P+ 
Sbjct: 123 PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQG 182

Query: 536 PPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPP 595
           PP  GG++  G  P P  P      G +      PP  P+         S  + +P   P
Sbjct: 183 PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKP 242

Query: 596 KGLA--------GPPASPGKAQPPKPERVTSLRSP------------GASVSSSLTSLCS 635
           +G          GPP  PGK Q P P+     + P            G S S S  S   
Sbjct: 243 QGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPG 302

Query: 636 SSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPP-SKPRSPNP-----AAPALAA 689
               P P   + PQ   P   +   PP      P  PPP  KP+ P P     +  A + 
Sbjct: 303 KPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSP 362

Query: 690 PAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPP 743
           P    GP      +PQ PP P        ++P   + Q  PP PP    P  PP
Sbjct: 363 PGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQG-PPRPPQGGRPSRPP 415



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 97/366 (26%), Positives = 111/366 (30%), Gaps = 120/366 (32%)

Query: 704  PQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEP 763
            PQ PP+P              K Q PPP        PPPP  KP+              P
Sbjct: 47   PQGPPSPP------------GKPQGPPPQGGNQPQGPPPPPGKPQ------------GPP 82

Query: 764  LQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSAT 823
             Q  N P  PPP  + Q       PPP+       S  P  P G P+    P     +  
Sbjct: 83   PQGGNKPQGPPPPGKPQG------PPPQ----GDKSRSPRSPPGKPQ---GPPPQGGN-- 127

Query: 824  ALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSL 883
                QP G P PP  P  P P           PQ  P      G PP+ D          
Sbjct: 128  ----QPQGPPPPPGKPQGPPPQGG------NKPQGPPPPGKPQGPPPQGDN--------- 168

Query: 884  LQMVRLRSVGAPGGAPT--PALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSL 941
                + RS  +P G P   P  G + PQ P          P P    G            
Sbjct: 169  ----KSRSSRSPPGKPQGPPPQGGNQPQGP---------PPPPGKPQG------------ 203

Query: 942  AASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLER-----PVSPETQADLQ 996
                     +P GPP   P  PQ P         +G  K Q  R     P  P  Q   Q
Sbjct: 204  --PPPQGGNKPQGPPP--PGKPQGPPP-------QGDNKSQSARSPPGKPQGPPPQGGNQ 252

Query: 997  RNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLP 1056
                        Q PP  P K P+ PPP       G PPP  P  P       PP  G  
Sbjct: 253  -----------PQGPPPPPGK-PQGPPPQGGNKPQGPPPPGKPQGP-------PPQGGSK 293

Query: 1057 HTQDRT 1062
                R+
Sbjct: 294  SRSSRS 299



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 69/285 (24%), Positives = 91/285 (31%), Gaps = 27/285 (9%)

Query: 810  ELVSSPAASSSSATALQIQPPGSPDPPPAPPA-PAPASSAPGHVAKLPQKEPVGCSKGGG 868
            E VS   + S  A   Q  PP   + P  PP+ P      P      PQ  P    K  G
Sbjct: 21   EDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQG 80

Query: 869  PPREDVGAPLVTP-------SLLQMVRLRSVGAPGGAP---------TPALGPSAPQKPL 912
            PP +    P   P          Q  + RS  +P G P          P   P  P KP 
Sbjct: 81   PPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 140

Query: 913  RRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGP-------PEAEPRPPQS 965
                 G   P   P  G       +  + + S      +P GP       P+  P PP  
Sbjct: 141  GPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGK 200

Query: 966  PASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPV 1025
            P        +K        +P  P  Q D  ++  A       Q PP      P+ PPP 
Sbjct: 201  PQGPPPQGGNKPQGPPPPGKPQGPPPQGD-NKSQSARSPPGKPQGPPPQGGNQPQGPPPP 259

Query: 1026 ARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENG 1070
              KP    PPP   + P+  P    P    P    +++   +  G
Sbjct: 260  PGKPQ--GPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPG 302



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 57/215 (26%), Positives = 75/215 (34%), Gaps = 35/215 (16%)

Query: 402 PQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGR 461
           P  + + P    D  S S  S      G     +GG++ Q           PPPQGG+  
Sbjct: 217 PPGKPQGPPPQGDNKSQSARSPPGKPQGPP--PQGGNQPQGPPPPPGKPQGPPPQGGNKP 274

Query: 462 ------GSPSGGSTAEASDTLSIRSS-GQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAV 514
                 G P G      S + S RS  G+  G         + PPPP             
Sbjct: 275 QGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPP------------- 321

Query: 515 PDGPLGLPP----KPERKQQPQLPR-PPTTGGSEGAGAAPCPPNPA--------NSWVPG 561
           P  P G PP    KP+    P  P+ PP  GGS+   A   P  P         N   P 
Sbjct: 322 PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPP 381

Query: 562 LSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPK 596
              GG+ + P++P            Q G P+ PP+
Sbjct: 382 PPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ 416


>gi|221139926 NHS-like 1 [Homo sapiens]
          Length = 1606

 Score =  120 bits (301), Expect = 7e-27
 Identities = 190/754 (25%), Positives = 274/754 (36%), Gaps = 136/754 (18%)

Query: 383  HSASPASVRSLGRFSSVSSPQPRSRHPSSS-----SDTWSHSQSSDTIVSDGSTLSSKGG 437
            H A+P         SS S  Q  ++  + S      D +  S  +D+    G+  +S  G
Sbjct: 569  HLATPGYSTPTSNMSSCSLDQTSNKEDAGSLYSEDHDGYCASVHTDSGHGSGNLCNSSDG 628

Query: 438  SEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRP 497
              G P  S  +  V        GR   + G  +   D        +   R++SL+K K+P
Sbjct: 629  F-GNPRHSVINVFV--------GRAQKNQGDRSNYQD--------KSLSRNISLKKAKKP 671

Query: 498  PPPPRRTHSL------------------------HQRGLAVPDGPLGLPPKPER---KQQ 530
            P PP RT SL                        H   L++P G  G  P        ++
Sbjct: 672  PLPPSRTDSLRRIPKKSSQCNGQVLNESLIATLQHSLQLSLP-GKSGSSPSQSPCSDLEE 730

Query: 531  PQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGT 590
            P LPR  +        +      P    + G +P  S       E T  P   Y   +G 
Sbjct: 731  PWLPRSRSQSTVSAGSSMTSATTPNVYSLCGATPSQSDTSSVKSEYT-DPWGYYIDYTGM 789

Query: 591  PTLPPKGLAGPPASPGKAQPPKP-------ERVTSLRSPGASVSSSLTSLCSSSSDPAPS 643
               P     G   S G      P        R T  + PG SV   + S   S    +PS
Sbjct: 790  QEDPGNPAGGCSTSSGVPTGNGPVRHVQEGSRATMPQVPGGSVKPKIMSPEKSHRVISPS 849

Query: 644  DRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDAS 703
                 Q  TP      + P P      SP   K + P P  P   +  +    +S++  S
Sbjct: 850  SGYSSQSNTPTA----LTPVPVFLKSVSPANGKGK-PKPKVPERKSSLISSVSISSSSTS 904

Query: 704  PQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEP 763
              S  + + + T  +  P +    +PPP P PS   P P  + P +    P    +   P
Sbjct: 905  LSSSTSTEGSGTMKKLDPAVGSPPAPPPPPVPSPPFPCPADRSPFLPPPPPVTDCSQGSP 964

Query: 764  L-QDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSA 822
            L   P +PPPPP A       +  F  P +   S     P  P+ SP L  SP       
Sbjct: 965  LPHSPVFPPPPPEA-------LIPFCSPPDWCLS-----PPRPALSPILPDSP------- 1005

Query: 823  TALQIQPP--GSPDPPPAPP---------APAPASSAPGHVAKLPQKEPVGCSKGGGPPR 871
             +L + PP   S +PPPAPP          P   +S     ++   + P    +   PP 
Sbjct: 1006 VSLPLPPPLLPSSEPPPAPPLDPKFMKDTRPPFTNSGQPESSRGSLRPPSTKEETSRPP- 1064

Query: 872  EDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLH 931
                 PL+T   LQMV+LR V    GA    L     Q+        + +PV AP   L 
Sbjct: 1065 ----MPLITTEALQMVQLRPVRKNSGAEAAQLSERTAQE--------QRTPV-APQYHLK 1111

Query: 932  AAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLER--PVSP 989
             +  LK+ + + +E  S +QP     + P P +S         S+G      ER  PVS 
Sbjct: 1112 PSAFLKSRN-STNEMESESQPASVTSSLPTPAKSS--------SQGDHGSAAERGGPVSR 1162

Query: 990  ETQADLQRNLVAELRSISEQRPPQAPKKSP-KAPPPVARKPS--VGVPPP-----ASPSY 1041
               A       AE R      P   P  SP + PPP+++KP   + VPPP       P+ 
Sbjct: 1163 SPGAPSAGE--AEARPSPSTTP--LPDSSPSRKPPPISKKPKLFLVVPPPQKDFAVEPAE 1218

Query: 1042 PRAEPLTAPPT-----NGLPHTQDRTKRELAENG 1070
              +E L A P+      G  H+++  +   A+ G
Sbjct: 1219 NVSEALRAVPSPTTGEEGSVHSREAKESSAAQAG 1252



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 117/504 (23%), Positives = 185/504 (36%), Gaps = 93/504 (18%)

Query: 399  VSSPQPRSR--HPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQ 456
            + SP+   R   PSS   + S++ ++ T V       S    +G+P+        VP  +
Sbjct: 836  IMSPEKSHRVISPSSGYSSQSNTPTALTPVPVFLKSVSPANGKGKPKPK------VPERK 889

Query: 457  GGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPD 516
                       S+   S + S   SG +     ++     PPPPP            VP 
Sbjct: 890  SSLISSVSISSSSTSLSSSTSTEGSGTMKKLDPAVGSPPAPPPPP------------VPS 937

Query: 517  GPLGLPPKPERKQQPQLPRPPTTGGSEGAG---AAPCPPNPANSWVPGLSPGG-SRRPPR 572
             P    P P  +     P PP T  S+G+    +   PP P  + +P  SP      PPR
Sbjct: 938  PPF---PCPADRSPFLPPPPPVTDCSQGSPLPHSPVFPPPPPEALIPFCSPPDWCLSPPR 994

Query: 573  SPERTLSPSSGYSSQSGTPTLP-----------PKGLAG----------PPASPGKAQPP 611
                 + P S  S     P LP           PK +            P +S G  +PP
Sbjct: 995  PALSPILPDSPVSLPLPPPLLPSSEPPPAPPLDPKFMKDTRPPFTNSGQPESSRGSLRPP 1054

Query: 612  KPERVTSLRSPGASVSSSLTSLC-------SSSSDPAP-SDRSGPQILTPLGDRFVIPPH 663
              +  TS R P   +++    +        +S ++ A  S+R+  +  TP+  ++ + P 
Sbjct: 1055 STKEETS-RPPMPLITTEALQMVQLRPVRKNSGAEAAQLSERTAQEQRTPVAPQYHLKPS 1113

Query: 664  PKVPAPFSP----PPSKPRSPNPAAPALA---------APAVVPGPVSTTDASP-----Q 705
              + +  S       S+P S   + P  A         + A   GPVS +  +P     +
Sbjct: 1114 AFLKSRNSTNEMESESQPASVTSSLPTPAKSSSQGDHGSAAERGGPVSRSPGAPSAGEAE 1173

Query: 706  SPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEV-VVEAPSASETAEEPL 764
            + P+P TT               P P   PS   PPP +KKP++ +V  P   + A EP 
Sbjct: 1174 ARPSPSTT---------------PLPDSSPS-RKPPPISKKPKLFLVVPPPQKDFAVEPA 1217

Query: 765  QDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATA 824
            ++ +      P+P   +         +E+  + A      P G+  L    A S S +  
Sbjct: 1218 ENVSEALRAVPSPTTGEEGSVHSREAKESSAAQAGSHATHP-GTSVLEGGAAGSMSPSRV 1276

Query: 825  LQIQPPGSPDPPPAPPAPAPASSA 848
                P   PD  PAP    PA ++
Sbjct: 1277 EANVPMVQPDVSPAPKQEEPAENS 1300



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 242/1122 (21%), Positives = 374/1122 (33%), Gaps = 238/1122 (21%)

Query: 105  QDNVFFPSGRPPHLEELHTQAQEGLRSLQHQEKQKLNKGG------WDHGDTQSIQSS-- 156
            Q+NVF P+ RPP +E+LH QA+  L+S+  +E  KL   G      +  G T +  +S  
Sbjct: 41   QENVFLPTTRPPCVEDLHRQAKLNLKSVL-RECDKLRHDGYRSSQYYSQGPTFAANASPF 99

Query: 157  ---RTGPDEDNISFCSQTTSY----------------------------------VAESS 179
                   DE+    CS ++S                                     E  
Sbjct: 100  CDDYQDEDEETDQKCSLSSSEEERFISIRRPKTPASSDFSDLNTQTNWTKSLPLPTPEEK 159

Query: 180  TAEDALSIRSEM--IQRKGSTFRPHDSFPKS----GKSGRRRR--ERRSTVLGLPQHVQK 231
              + A ++++++  I   G  F    S  +S        RR +  +RR T+ G+P ++QK
Sbjct: 160  MRQQAQTVQADVVPINITGENFDRQASLRRSLIYTDTLVRRPKKVKRRKTITGVPDNIQK 219

Query: 232  ELGLRNEREAPGTPRAPGARDAVRIPTVDGRPRGTSGMGARVSLQALEAEAEAGAETEAM 291
            EL       A GT    G  DA      DG    T    +  +L    +   AG  +E  
Sbjct: 220  EL-------ASGT----GQDDA------DGHSVYTPDHYS--TLGRFNSCRSAGQRSET- 259

Query: 292  LQRHIDRVYRDDTFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYL 351
                     RD +          P + R  +    G+    G     S  MS+   +  +
Sbjct: 260  ---------RDSSCQTEDVKVVPPSMRRIRAQKGQGIAAQMGHFSGSSGNMSVLSDSAGI 310

Query: 352  SKLIPHAVLPPTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSR-HPS 410
                   V P  +D  A      R+ +R ++ S  P  + +LG    ++      R HP 
Sbjct: 311  -------VFPSRLDSDAGFHSLPRSGARANIQSLEP-RLGALGPAGDMNGTFLYQRGHPQ 362

Query: 411  SSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPES-------------STASNSVVPPPQG 457
            +  +      +S T    G+ L  K       ES             +T S S++P    
Sbjct: 363  ADENLGHLGGASGT----GTLLRPKSQELRHFESENIMSPACVVSPHATYSTSIIPNATL 418

Query: 458  GSGR---GSPSGGSTAEASDTLSIRSSGQLSGRS--VSLRKLKRPPPPPRRTHSLHQRGL 512
             S       P+  S  +     S  S  ++  R   +S   +K  P  P R  +     +
Sbjct: 419  SSSSEVIAIPTAQSAGQRESKSSGSSHARIKSRDHLISRHAVKGDPQSPGRHWNEGHATI 478

Query: 513  AVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPR 572
               D     P +P          P     +   G+   P N  N+      P   +    
Sbjct: 479  LSQDLDPHSPGEPALLSLCDSAVPLNAPANRENGSQAMPYNCRNNLA---FPAHPQDVDG 535

Query: 573  SPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTS 632
              E + S   G+SS         +      +  G+A P KP     L +PG S  +S  S
Sbjct: 536  KSESSYSGGGGHSSS--------EPWEYKSSGNGRASPLKPH----LATPGYSTPTSNMS 583

Query: 633  LCS----SSSDPAPSDRS----------------GPQILTPLGDRFVIPPH--------- 663
             CS    S+ + A S  S                G   L    D F  P H         
Sbjct: 584  SCSLDQTSNKEDAGSLYSEDHDGYCASVHTDSGHGSGNLCNSSDGFGNPRHSVINVFVGR 643

Query: 664  -PKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTP---------QTT 713
              K     S    K  S N +      P   P P S TD+  + P            ++ 
Sbjct: 644  AQKNQGDRSNYQDKSLSRNISLKKAKKP---PLPPSRTDSLRRIPKKSSQCNGQVLNESL 700

Query: 714  LTPLQESPVIS----KDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNW 769
            +  LQ S  +S       SP  SP      P  P  + +  V A S+  +A      PN 
Sbjct: 701  IATLQHSLQLSLPGKSGSSPSQSPCSDLEEPWLPRSRSQSTVSAGSSMTSA----TTPNV 756

Query: 770  PPPPPPAPEEQDLS--MADFPPPEEAF--FSVASPEPAGPSGSPELVSSPAASSSSATAL 825
                   P + D S   +++  P   +  ++    +P  P+G     S     +     +
Sbjct: 757  YSLCGATPSQSDTSSVKSEYTDPWGYYIDYTGMQEDPGNPAGGCSTSSGVPTGNGPVRHV 816

Query: 826  QIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQ 885
            Q    GS    P  P     S  P  ++  P+K     S   G   +      +TP    
Sbjct: 817  Q---EGSRATMPQVPG---GSVKPKIMS--PEKSHRVISPSSGYSSQSNTPTALTP---V 865

Query: 886  MVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKAC-SLAAS 944
             V L+SV     +P    G   P+ P R++    +  + + S+ L ++   +   ++   
Sbjct: 866  PVFLKSV-----SPANGKGKPKPKVPERKSSLISSVSISSSSTSLSSSTSTEGSGTMKKL 920

Query: 945  EGLSSAQPNGPPEAEPRPP-QSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAEL 1003
            +    + P  PP   P PP   PA  + F+            P  P T  D  +      
Sbjct: 921  DPAVGSPPAPPPPPVPSPPFPCPADRSPFL-----------PPPPPVT--DCSQGSPLPH 967

Query: 1004 RSISEQRPPQA--PKKSPK----APPPVARKP-------SVGVPPPASPSYPRAEPLTAP 1050
              +    PP+A  P  SP     +PP  A  P       S+ +PPP  PS   +EP  AP
Sbjct: 968  SPVFPPPPPEALIPFCSPPDWCLSPPRPALSPILPDSPVSLPLPPPLLPS---SEPPPAP 1024

Query: 1051 PTNGLPHTQDRTKRELAENGGVLQLVGPEEKMGLPGSDSQKE 1092
            P +  P     T+     +G       PE   G     S KE
Sbjct: 1025 PLD--PKFMKDTRPPFTNSG------QPESSRGSLRPPSTKE 1058



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 96/403 (23%), Positives = 142/403 (35%), Gaps = 46/403 (11%)

Query: 314  APPLT-RPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRC 372
            APPL  + M    P  T      +P S   S+ P +T      P     P +   AL   
Sbjct: 1023 APPLDPKFMKDTRPPFTNSG---QPESSRGSLRPPSTKEETSRPPM---PLITTEALQMV 1076

Query: 373  SLRTLSRCSLHSASPASVRSLGRFSSVSSPQ----PRSRHPSSSSDTWSHSQSSDTIVSD 428
             LR + + S   A+  S R+     +  +PQ    P +   S +S     S+S    V+ 
Sbjct: 1077 QLRPVRKNSGAEAAQLSERTAQEQRTPVAPQYHLKPSAFLKSRNSTNEMESESQPASVTS 1136

Query: 429  GSTLSSKGGSEGQPESSTASNSVVP----PPQGGSGRGSPSGGSTAEASDTLSIRSSGQL 484
                 +K  S+G   S+      V      P  G     PS  ST    D+   R    +
Sbjct: 1137 SLPTPAKSSSQGDHGSAAERGGPVSRSPGAPSAGEAEARPSP-STTPLPDSSPSRKPPPI 1195

Query: 485  SGRSVSLRKLKRPPPPPRR------THSLHQRGLAVPD---GPLGLPPKPERKQQPQLPR 535
            S +     KL    PPP++        ++ +   AVP    G  G     E K+      
Sbjct: 1196 SKKP----KLFLVVPPPQKDFAVEPAENVSEALRAVPSPTTGEEGSVHSREAKESSAAQA 1251

Query: 536  P-----PTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGT 590
                  P T   EG  A    P+   + VP + P  S  P +      S  +G   +S  
Sbjct: 1252 GSHATHPGTSVLEGGAAGSMSPSRVEANVPMVQPDVSPAPKQEEPAENSADTGGDGESCL 1311

Query: 591  PTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQI 650
                  G AG P +   A     E    L+  G     + +   ++    A   RS  ++
Sbjct: 1312 SQ--QDGAAGVPET--NAAGSSSEACDFLKEDGNDEVMTPSRPRTTEDLFAAIHRSKRKV 1367

Query: 651  LTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVV 693
            L   G R     H +     +  PS P +P  AAP+LA+P  V
Sbjct: 1368 L---GRRDSDDDHSR-----NHSPSPPVTPTGAAPSLASPKQV 1402


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score =  119 bits (299), Expect = 1e-26
 Identities = 122/420 (29%), Positives = 155/420 (36%), Gaps = 82/420 (19%)

Query: 540 GGSEGAGAAPCPPNPANSWVPGL-------SPGGSRRPPRSPERTLSPSSGYSSQSGTPT 592
           GGS G G  P       + +P L       +  G  RPP  P        G  S S  P 
Sbjct: 89  GGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPP-------GGRSTSAKPF 141

Query: 593 LPPKGLAG-PPASPG-KAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQI 650
            PP G    P  SPG ++ PP+P+R   +  P   V S   S+      P PS    P+ 
Sbjct: 142 SPPSGPGRFPVPSPGHRSGPPEPQR-NRMPPPRPDVGSKPDSI----PPPVPST---PRP 193

Query: 651 LTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTP 710
           +         PP P  P   SP P+ P  P     AL   ++   P+S++      PP P
Sbjct: 194 IQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLP 253

Query: 711 QTTLTPLQESPVISKDQSPPPSPP----PSYH----PPPPPTKKPEVVVEAPSASETAEE 762
            T    L + P       PPP PP    PS H    PPPPP      V   P  S +++ 
Sbjct: 254 PTPSRALDDKP-------PPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQA 306

Query: 763 PLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSA 822
           P      PPPPPP+           PPP         P  +G   +P L     + SSS 
Sbjct: 307 P------PPPPPPS--------RPGPPP-------LPPSSSGNDETPRLPQRNLSLSSST 345

Query: 823 TALQIQPPGSPDPPPAPPA---PAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLV 879
             L    PG   P P PP+   P P    PG    LP   PV  S+ G   R        
Sbjct: 346 PPL--PSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPV--SRNGSTSR-------A 394

Query: 880 TPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKAC 939
            P+  Q+     V +P   P P L P  P        S  A P P PS+ +    +   C
Sbjct: 395 LPATPQLPSRSGVDSPRSGPRPPLPPDRP--------SAGAPPPPPPSTSIRNGFQDSPC 446



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 114/409 (27%), Positives = 151/409 (36%), Gaps = 79/409 (19%)

Query: 390 VRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQS-SDTIVSDGSTLSSKGGSEGQPE----S 444
           V S G  S    PQ R+R P    D  S   S    + S    + S   + G P      
Sbjct: 152 VPSPGHRSGPPEPQ-RNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGP 210

Query: 445 STASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGR-------SVSLRKLKRP 497
              S    PPP  G+ RG+  GG +   S    + SS   S R       S +L     P
Sbjct: 211 RQPSPGPTPPPFPGN-RGTALGGGSIRQSP---LSSSSPFSNRPPLPPTPSRALDDKPPP 266

Query: 498 PPPPRRTH-SLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPAN 556
           PPPP     S+H+  +  P      PP+  +   P  PRP     S  + A P PP P+ 
Sbjct: 267 PPPPVGNRPSIHREAVPPP------PPQNNKPPVPSTPRP-----SASSQAPPPPPPPSR 315

Query: 557 SWVPGLSPG--GSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPE 614
              P L P   G+   PR P+R LS SS       TP LP  G +GP   P   +PP P 
Sbjct: 316 PGPPPLPPSSSGNDETPRLPQRNLSLSSS------TPPLPSPGRSGPLPPPPSERPPPPV 369

Query: 615 RVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPP 674
           R                          P  RSGP           +PP P V    S   
Sbjct: 370 R-------------------------DPPGRSGP-----------LPPPPPVSRNGSTSR 393

Query: 675 SKPRSPN-PAAPALAAPAVVPGPVSTTD---ASPQSPPTPQTTL-TPLQESPVISKDQSP 729
           + P +P  P+   + +P   P P    D   A    PP P T++    Q+SP   + +S 
Sbjct: 394 ALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESR 453

Query: 730 PPSPPPSYHPPPPP-TKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAP 777
               P S  PPP P  +  +      + +E+     +     PP PP P
Sbjct: 454 FYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIP 502



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 118/419 (28%), Positives = 152/419 (36%), Gaps = 95/419 (22%)

Query: 457 GGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKL----KRPPPPPRRTHSLHQRGL 512
           GG G GS  GG          +  +G    RS + R       RPP  P    S   +  
Sbjct: 85  GGGGGGSFGGGGPPGLG---GLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPF 141

Query: 513 AVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPR 572
           + P GP   P          +P P    G         PP P  + +P   P    +P  
Sbjct: 142 SPPSGPGRFP----------VPSPGHRSG---------PPEPQRNRMPPPRPDVGSKPDS 182

Query: 573 SPE---RTLSPSSGYSSQSGTPTLPPKGLAGP-PASPGKAQPPKP-ERVTSLRSPGASVS 627
            P     T  P        G+P +P     GP   SPG   PP P  R T+L   G S+ 
Sbjct: 183 IPPPVPSTPRPIQSSPHNRGSPPVP----GGPRQPSPGPTPPPFPGNRGTALG--GGSIR 236

Query: 628 SSLTSLCSSSSD-----PAPS---DRSGPQILTPLGDR-----FVIPPHP----KVPAPF 670
            S  S  S  S+     P PS   D   P    P+G+R       +PP P    K P P 
Sbjct: 237 QSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPS 296

Query: 671 SPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPP 730
           +P PS      P  P  + P   P P S++  + ++P  PQ  L+    +P +       
Sbjct: 297 TPRPSASSQAPPPPPPPSRPGPPPLPPSSS-GNDETPRLPQRNLSLSSSTPPLPSPGRSG 355

Query: 731 PSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPP 790
           P PPP    PPPP + P      P  S     PL      PPPPP       S A     
Sbjct: 356 PLPPPPSERPPPPVRDP------PGRS----GPL------PPPPPVSRNGSTSRA----- 394

Query: 791 EEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPP--APPAPAPASS 847
                  A+P+    SG    V SP +          +PP  PD P   APP P P++S
Sbjct: 395 -----LPATPQLPSRSG----VDSPRSGP--------RPPLPPDRPSAGAPPPPPPSTS 436



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 111/427 (25%), Positives = 144/427 (33%), Gaps = 102/427 (23%)

Query: 623  GASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNP 682
            G    + +  L S+++    S  S P +L P G             PFSPP    R P P
Sbjct: 101  GGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGG-------RSTSAKPFSPPSGPGRFPVP 153

Query: 683  AAPALAAPAV-----VPGPVSTTDASPQS-PPTPQTTLTPLQESPVISKDQSPPPSPPPS 736
            +    + P       +P P     + P S PP   +T  P+Q SP  ++   P P  P  
Sbjct: 154  SPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPH-NRGSPPVPGGPRQ 212

Query: 737  YHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFS 796
              P P P   P     A       + PL   +     PP P     ++ D PPP      
Sbjct: 213  PSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPP----- 267

Query: 797  VASPEPAG--PSGSPELVSSPAASSSSATALQIQPPGSPDPP-PAPPAPAPASSAPGHVA 853
               P P G  PS   E V  P             PP +  PP P+ P P+ +S AP    
Sbjct: 268  ---PPPVGNRPSIHREAVPPP-------------PPQNNKPPVPSTPRPSASSQAPPPP- 310

Query: 854  KLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLR 913
                           PP    G P + PS           + G   TP L    PQ+ L 
Sbjct: 311  ---------------PPPSRPGPPPLPPS-----------SSGNDETPRL----PQRNL- 339

Query: 914  RALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFI 973
             +LS    P+P+P                   G S   P  P E  P P + P       
Sbjct: 340  -SLSSSTPPLPSP-------------------GRSGPLPPPPSERPPPPVRDPPGR---- 375

Query: 974  FSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGV 1033
                S  L    PVS             +L S S      +P+  P+ P P  R PS G 
Sbjct: 376  ----SGPLPPPPPVSRNGSTSRALPATPQLPSRSGV---DSPRSGPRPPLPPDR-PSAGA 427

Query: 1034 PPPASPS 1040
            PPP  PS
Sbjct: 428  PPPPPPS 434



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 81/306 (26%), Positives = 112/306 (36%), Gaps = 61/306 (19%)

Query: 754  PSASETAEEPLQDPNWPPP-PPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELV 812
            P    T+ +P   P+ P   P P+P  +        PPE     +  P P   S  P+ +
Sbjct: 131  PGGRSTSAKPFSPPSGPGRFPVPSPGHRS------GPPEPQRNRMPPPRPDVGS-KPDSI 183

Query: 813  SSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPRE 872
              P  S+           GSP  P  P  P+P  + P      P     G + GGG  R+
Sbjct: 184  PPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPP------PFPGNRGTALGGGSIRQ 237

Query: 873  DVGAPLVTPSLLQMVRLRSVGAPGGAPTPALG----PSAPQKPL--RRALSGRASPVPAP 926
               +PL + S            P   PTP+      P  P  P+  R ++   A P P P
Sbjct: 238  ---SPLSSSSPFS-------NRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPP 287

Query: 927  SSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERP 986
             +      +    S       S A P  PP + P PP  P S++                
Sbjct: 288  QNN-----KPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSG--------------- 327

Query: 987  VSPETQADLQRNLVAELRSISEQRPP-QAPKKSPKAPPPVARKPSVGVPPPASPSYPRAE 1045
             + ET    QRNL     S+S   PP  +P +S   PPP + +P    PPP      R+ 
Sbjct: 328  -NDETPRLPQRNL-----SLSSSTPPLPSPGRSGPLPPPPSERP----PPPVRDPPGRSG 377

Query: 1046 PLTAPP 1051
            PL  PP
Sbjct: 378  PLPPPP 383



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 73/295 (24%), Positives = 104/295 (35%), Gaps = 45/295 (15%)

Query: 806  SGSPELVSSPAASSSSATALQ-IQPPGS------PDPPPAPPAPAPASSAPGHVAKLPQK 858
            +G P+L S+    + S  +   + PPG       P  PP+ P   P  S PGH +  P+ 
Sbjct: 106  AGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPS-PGHRSGPPEP 164

Query: 859  EPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSG 918
            +         PPR DVG+                  P   P P   PS P +P++ +   
Sbjct: 165  Q----RNRMPPPRPDVGSK-----------------PDSIPPPV--PSTP-RPIQSSPHN 200

Query: 919  RASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGS 978
            R SP P P      +          + G  +A   G     P    SP S    +    S
Sbjct: 201  RGSP-PVPGGPRQPSPGPTPPPFPGNRG--TALGGGSIRQSPLSSSSPFSNRPPLPPTPS 257

Query: 979  RKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVG--VPPP 1036
            R L  + P  P          V    SI  +  P  P ++ K P P   +PS     PPP
Sbjct: 258  RALDDKPPPPPPP--------VGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP 309

Query: 1037 ASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVLQLVGPEEKMGLPGSDSQK 1091
              P      P   P ++G   T    +R L+ +     L  P     LP   S++
Sbjct: 310  PPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSER 364


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score =  119 bits (299), Expect = 1e-26
 Identities = 122/420 (29%), Positives = 155/420 (36%), Gaps = 82/420 (19%)

Query: 540 GGSEGAGAAPCPPNPANSWVPGL-------SPGGSRRPPRSPERTLSPSSGYSSQSGTPT 592
           GGS G G  P       + +P L       +  G  RPP  P        G  S S  P 
Sbjct: 89  GGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPP-------GGRSTSAKPF 141

Query: 593 LPPKGLAG-PPASPG-KAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQI 650
            PP G    P  SPG ++ PP+P+R   +  P   V S   S+      P PS    P+ 
Sbjct: 142 SPPSGPGRFPVPSPGHRSGPPEPQR-NRMPPPRPDVGSKPDSI----PPPVPST---PRP 193

Query: 651 LTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTP 710
           +         PP P  P   SP P+ P  P     AL   ++   P+S++      PP P
Sbjct: 194 IQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLP 253

Query: 711 QTTLTPLQESPVISKDQSPPPSPP----PSYH----PPPPPTKKPEVVVEAPSASETAEE 762
            T    L + P       PPP PP    PS H    PPPPP      V   P  S +++ 
Sbjct: 254 PTPSRALDDKP-------PPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQA 306

Query: 763 PLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSA 822
           P      PPPPPP+           PPP         P  +G   +P L     + SSS 
Sbjct: 307 P------PPPPPPS--------RPGPPP-------LPPSSSGNDETPRLPQRNLSLSSST 345

Query: 823 TALQIQPPGSPDPPPAPPA---PAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLV 879
             L    PG   P P PP+   P P    PG    LP   PV  S+ G   R        
Sbjct: 346 PPL--PSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPV--SRNGSTSR-------A 394

Query: 880 TPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKAC 939
            P+  Q+     V +P   P P L P  P        S  A P P PS+ +    +   C
Sbjct: 395 LPATPQLPSRSGVDSPRSGPRPPLPPDRP--------SAGAPPPPPPSTSIRNGFQDSPC 446



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 114/409 (27%), Positives = 151/409 (36%), Gaps = 79/409 (19%)

Query: 390 VRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQS-SDTIVSDGSTLSSKGGSEGQPE----S 444
           V S G  S    PQ R+R P    D  S   S    + S    + S   + G P      
Sbjct: 152 VPSPGHRSGPPEPQ-RNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGP 210

Query: 445 STASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGR-------SVSLRKLKRP 497
              S    PPP  G+ RG+  GG +   S    + SS   S R       S +L     P
Sbjct: 211 RQPSPGPTPPPFPGN-RGTALGGGSIRQSP---LSSSSPFSNRPPLPPTPSRALDDKPPP 266

Query: 498 PPPPRRTH-SLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPAN 556
           PPPP     S+H+  +  P      PP+  +   P  PRP     S  + A P PP P+ 
Sbjct: 267 PPPPVGNRPSIHREAVPPP------PPQNNKPPVPSTPRP-----SASSQAPPPPPPPSR 315

Query: 557 SWVPGLSPG--GSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPE 614
              P L P   G+   PR P+R LS SS       TP LP  G +GP   P   +PP P 
Sbjct: 316 PGPPPLPPSSSGNDETPRLPQRNLSLSSS------TPPLPSPGRSGPLPPPPSERPPPPV 369

Query: 615 RVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPP 674
           R                          P  RSGP           +PP P V    S   
Sbjct: 370 R-------------------------DPPGRSGP-----------LPPPPPVSRNGSTSR 393

Query: 675 SKPRSPN-PAAPALAAPAVVPGPVSTTD---ASPQSPPTPQTTL-TPLQESPVISKDQSP 729
           + P +P  P+   + +P   P P    D   A    PP P T++    Q+SP   + +S 
Sbjct: 394 ALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESR 453

Query: 730 PPSPPPSYHPPPPP-TKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAP 777
               P S  PPP P  +  +      + +E+     +     PP PP P
Sbjct: 454 FYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIP 502



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 118/419 (28%), Positives = 152/419 (36%), Gaps = 95/419 (22%)

Query: 457 GGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKL----KRPPPPPRRTHSLHQRGL 512
           GG G GS  GG          +  +G    RS + R       RPP  P    S   +  
Sbjct: 85  GGGGGGSFGGGGPPGLG---GLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPF 141

Query: 513 AVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPR 572
           + P GP   P          +P P    G         PP P  + +P   P    +P  
Sbjct: 142 SPPSGPGRFP----------VPSPGHRSG---------PPEPQRNRMPPPRPDVGSKPDS 182

Query: 573 SPE---RTLSPSSGYSSQSGTPTLPPKGLAGP-PASPGKAQPPKP-ERVTSLRSPGASVS 627
            P     T  P        G+P +P     GP   SPG   PP P  R T+L   G S+ 
Sbjct: 183 IPPPVPSTPRPIQSSPHNRGSPPVP----GGPRQPSPGPTPPPFPGNRGTALG--GGSIR 236

Query: 628 SSLTSLCSSSSD-----PAPS---DRSGPQILTPLGDR-----FVIPPHP----KVPAPF 670
            S  S  S  S+     P PS   D   P    P+G+R       +PP P    K P P 
Sbjct: 237 QSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPS 296

Query: 671 SPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPP 730
           +P PS      P  P  + P   P P S++  + ++P  PQ  L+    +P +       
Sbjct: 297 TPRPSASSQAPPPPPPPSRPGPPPLPPSSS-GNDETPRLPQRNLSLSSSTPPLPSPGRSG 355

Query: 731 PSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPP 790
           P PPP    PPPP + P      P  S     PL      PPPPP       S A     
Sbjct: 356 PLPPPPSERPPPPVRDP------PGRS----GPL------PPPPPVSRNGSTSRA----- 394

Query: 791 EEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPP--APPAPAPASS 847
                  A+P+    SG    V SP +          +PP  PD P   APP P P++S
Sbjct: 395 -----LPATPQLPSRSG----VDSPRSGP--------RPPLPPDRPSAGAPPPPPPSTS 436



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 111/427 (25%), Positives = 144/427 (33%), Gaps = 102/427 (23%)

Query: 623  GASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNP 682
            G    + +  L S+++    S  S P +L P G             PFSPP    R P P
Sbjct: 101  GGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGG-------RSTSAKPFSPPSGPGRFPVP 153

Query: 683  AAPALAAPAV-----VPGPVSTTDASPQS-PPTPQTTLTPLQESPVISKDQSPPPSPPPS 736
            +    + P       +P P     + P S PP   +T  P+Q SP  ++   P P  P  
Sbjct: 154  SPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPH-NRGSPPVPGGPRQ 212

Query: 737  YHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFS 796
              P P P   P     A       + PL   +     PP P     ++ D PPP      
Sbjct: 213  PSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPP----- 267

Query: 797  VASPEPAG--PSGSPELVSSPAASSSSATALQIQPPGSPDPP-PAPPAPAPASSAPGHVA 853
               P P G  PS   E V  P             PP +  PP P+ P P+ +S AP    
Sbjct: 268  ---PPPVGNRPSIHREAVPPP-------------PPQNNKPPVPSTPRPSASSQAPPPP- 310

Query: 854  KLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLR 913
                           PP    G P + PS           + G   TP L    PQ+ L 
Sbjct: 311  ---------------PPPSRPGPPPLPPS-----------SSGNDETPRL----PQRNL- 339

Query: 914  RALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFI 973
             +LS    P+P+P                   G S   P  P E  P P + P       
Sbjct: 340  -SLSSSTPPLPSP-------------------GRSGPLPPPPSERPPPPVRDPPGR---- 375

Query: 974  FSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGV 1033
                S  L    PVS             +L S S      +P+  P+ P P  R PS G 
Sbjct: 376  ----SGPLPPPPPVSRNGSTSRALPATPQLPSRSGV---DSPRSGPRPPLPPDR-PSAGA 427

Query: 1034 PPPASPS 1040
            PPP  PS
Sbjct: 428  PPPPPPS 434



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 81/306 (26%), Positives = 112/306 (36%), Gaps = 61/306 (19%)

Query: 754  PSASETAEEPLQDPNWPPP-PPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELV 812
            P    T+ +P   P+ P   P P+P  +        PPE     +  P P   S  P+ +
Sbjct: 131  PGGRSTSAKPFSPPSGPGRFPVPSPGHRS------GPPEPQRNRMPPPRPDVGS-KPDSI 183

Query: 813  SSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPRE 872
              P  S+           GSP  P  P  P+P  + P      P     G + GGG  R+
Sbjct: 184  PPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPP------PFPGNRGTALGGGSIRQ 237

Query: 873  DVGAPLVTPSLLQMVRLRSVGAPGGAPTPALG----PSAPQKPL--RRALSGRASPVPAP 926
               +PL + S            P   PTP+      P  P  P+  R ++   A P P P
Sbjct: 238  ---SPLSSSSPFS-------NRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPP 287

Query: 927  SSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERP 986
             +      +    S       S A P  PP + P PP  P S++                
Sbjct: 288  QNN-----KPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSG--------------- 327

Query: 987  VSPETQADLQRNLVAELRSISEQRPP-QAPKKSPKAPPPVARKPSVGVPPPASPSYPRAE 1045
             + ET    QRNL     S+S   PP  +P +S   PPP + +P    PPP      R+ 
Sbjct: 328  -NDETPRLPQRNL-----SLSSSTPPLPSPGRSGPLPPPPSERP----PPPVRDPPGRSG 377

Query: 1046 PLTAPP 1051
            PL  PP
Sbjct: 378  PLPPPP 383



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 73/295 (24%), Positives = 104/295 (35%), Gaps = 45/295 (15%)

Query: 806  SGSPELVSSPAASSSSATALQ-IQPPGS------PDPPPAPPAPAPASSAPGHVAKLPQK 858
            +G P+L S+    + S  +   + PPG       P  PP+ P   P  S PGH +  P+ 
Sbjct: 106  AGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPS-PGHRSGPPEP 164

Query: 859  EPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSG 918
            +         PPR DVG+                  P   P P   PS P +P++ +   
Sbjct: 165  Q----RNRMPPPRPDVGSK-----------------PDSIPPPV--PSTP-RPIQSSPHN 200

Query: 919  RASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGS 978
            R SP P P      +          + G  +A   G     P    SP S    +    S
Sbjct: 201  RGSP-PVPGGPRQPSPGPTPPPFPGNRG--TALGGGSIRQSPLSSSSPFSNRPPLPPTPS 257

Query: 979  RKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVG--VPPP 1036
            R L  + P  P          V    SI  +  P  P ++ K P P   +PS     PPP
Sbjct: 258  RALDDKPPPPPPP--------VGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP 309

Query: 1037 ASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVLQLVGPEEKMGLPGSDSQK 1091
              P      P   P ++G   T    +R L+ +     L  P     LP   S++
Sbjct: 310  PPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSER 364


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  114 bits (285), Expect = 5e-25
 Identities = 132/498 (26%), Positives = 182/498 (36%), Gaps = 84/498 (16%)

Query: 591   PTLPPKGLAGPPASPGKAQPPK--PERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGP 648
             P  PPKG    P    K  PPK  P +V   + P A V      +        P +   P
Sbjct: 10436 PKAPPKG----PEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVP 10491

Query: 649   QILTP--LGDRFVIP----PHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDA 702
                 P  L  + V+P    P P    P +PPP  P +P    P    P  VP P      
Sbjct: 10492 PTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVP--VPPP-----K 10544

Query: 703   SPQSPPT--PQTTLTPLQESPVIS----KDQSPPPSPP-------PSYHPPPPPTKKPEV 749
              P+ PPT  P+     + E  V      K +SPPP  P       P    P  P KKPEV
Sbjct: 10545 KPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEV 10604

Query: 750   V-VEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPP---PEEAFFSVASPEPAGP 805
               V+ P   E  +E + +   P PPP  PE     + + P    PE+       P+P  P
Sbjct: 10605 TPVKVP---EAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESP 10661

Query: 806   SGSPELVSSP---AASSSSATALQIQPPGSPDPPPAPPA-PAPASSAPGHVAKLPQKEPV 861
                PE+   P   A     A  ++   P +P     PP  P P   AP  VAK P+  PV
Sbjct: 10662 P--PEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPV 10719

Query: 862   GCSKGGGPPREDVGAPLVTPSL------------LQMVRLRSVGAPGGAPTP-ALGPSAP 908
                +       +   PLV P               ++V  + V  P     P A  P  P
Sbjct: 10720 KVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVP 10779

Query: 909   QKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPAS 968
             +KP+       A PVP  +      V  +   +A  E ++  +    P AE   P+ P  
Sbjct: 10780 KKPVLEEKP--AVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPP- 10836

Query: 969   TASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARK 1028
                              P  PE      + ++ E +    ++P   P K P+ P  V  K
Sbjct: 10837 -----------------PAVPEEP----KKIIPEKKVPVIKKPEAPPPKEPE-PEKVIEK 10874

Query: 1029  PSVGV-PPPASPSYPRAE 1045
             P +   PPP  P+ P+ +
Sbjct: 10875 PKLKPRPPPPPPAPPKED 10892



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 144/583 (24%), Positives = 206/583 (35%), Gaps = 81/583 (13%)

Query: 493   KLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPP 552
             K+  P  PP +     +    VP+ P  +  + E+ + P+ PR P T   E        P
Sbjct: 10448 KIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVE-EKVRVPEEPRVPPTKVPEVLPPKEVVP 10506

Query: 553   NPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPP---------A 603
                    P   P     PP+ PE   +P      +   P  PPK    PP         A
Sbjct: 10507 EKKVPVPPAKKPEAP--PPKVPE---APKEVVPEKK-VPVPPPKKPEVPPTKVPEVPKAA 10560

Query: 604   SPGK----AQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPA--PSDRSGPQILTPLGDR 657
              P K    A PPKPE      SP   V  +   +      PA  P       +  P   +
Sbjct: 10561 VPEKKVPEAIPPKPE------SPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPK 10614

Query: 658   FVIP----PHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTT 713
              V+P    P P    P  PP   P  P  A P    P  +P         P+SPP P+  
Sbjct: 10615 EVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIP-------PKPESPP-PEVF 10666

Query: 714   LTPLQ---ESPVISKDQSPPPSPPPSYHPPP----PPTKKPEVVVEAPS-----ASETAE 761
               P +   E P     + P P+ PP    PP    P  K P VV + P        E  +
Sbjct: 10667 EEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPK 10726

Query: 762   EPLQDPNWPPPPPPAPEEQDLSMADFPP---PEEAFFSVASPEPAGPSGSPELVSSPAAS 818
             E + +   P   P  PE     + + P    PE+       PE   P+  PE+   P   
Sbjct: 10727 EVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPE-VPPAKVPEVPKKPVLE 10785

Query: 819   SSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPL 878
                A  +    P   + PP      P   AP       +++PV  ++   P   +V  P 
Sbjct: 10786 EKPAVPV----PERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEP---EVPPPA 10838

Query: 879   VTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKA 938
             V     +++  + V        P      P+K + +    +  P P P +     V+ K 
Sbjct: 10839 VPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKL-KPRPPPPPPAPPKEDVKEKI 10897

Query: 939   CSLAA-SEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQR 997
               L A  +     +P  P + E  P + P         K  RKL  ER   P+ +     
Sbjct: 10898 FQLKAIPKKKVPEKPQVPEKVELTPLKVPGG------EKKVRKLLPERKPEPKEEV---- 10947

Query: 998   NLVAELRSISEQRPPQA-PKKSPKAPPPVARKPSVGVPPPASP 1039
                  L+S+  +RP +  PK  PK    V +KP+V  PPP  P
Sbjct: 10948 ----VLKSVLRKRPEEEEPKVEPKKLEKV-KKPAVPEPPPPKP 10985



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 141/585 (24%), Positives = 198/585 (33%), Gaps = 106/585 (18%)

Query: 495   KRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNP 554
             K+P  PP +   + +  +     P  +PPKPE    P++P  P     E    A  P  P
Sbjct: 10544 KKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPE-SPPPEVPEAPKEVVPEKKVPAAPPKKP 10602

Query: 555   ANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPP--ASPGK----A 608
               + V         + P +P+  +            P +PP  +   P  A P K    A
Sbjct: 10603 EVTPV---------KVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEA 10653

Query: 609   QPPKPERVTSLRSPGASVSSSLTSLCSSSSDPA-----PSDRSGPQILTPLGDRFVIPPH 663
              PPKPE      SP   V      + +    PA     P   + PQ+  P        P 
Sbjct: 10654 IPPKPE------SPPPEVFEEPEEV-ALEEPPAEVVEEPEPAAPPQVTVPPKKPV---PE 10703

Query: 664   PKVPA-----PFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQ 718
              K PA     P  PP   P  P    P    P VVP         P++PP          
Sbjct: 10704 KKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVP-------KKPEAPPA--------- 10747

Query: 719   ESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPE 778
             + P + K+  P         P  PP K PEV  + P   E    P+ +    PPP    E
Sbjct: 10748 KVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVP-KKPVLEEKPAVPVPERAESPPPEVYEE 10806

Query: 779   EQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPA 838
              ++++  +   PEE       P P      PE V  PA         +I P         
Sbjct: 10807 PEEIAPEEEIAPEEE-----KPVPVAEEEEPE-VPPPAVPEEPK---KIIPEKKVPVIKK 10857

Query: 839   PPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVT------------PSLLQM 886
             P AP P    P  V + P+ +P        PP+EDV   +              P + + 
Sbjct: 10858 PEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEK 10917

Query: 887   VRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAAS-E 945
             V L  +  PGG           +K +R+ L  R  P P     L + +R +        E
Sbjct: 10918 VELTPLKVPGG-----------EKKVRKLLPER-KPEPKEEVVLKSVLRKRPEEEEPKVE 10965

Query: 946   GLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRS 1005
                  +   P   EP PP+          +K  RK+       PE           ++  
Sbjct: 10966 PKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKI-------PEP---------TKVPE 11009

Query: 1006  ISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAP 1050
             I    P  AP+  PK   P A   ++  PP      P A P+T P
Sbjct: 11010 IKPAIPLPAPEPKPK---PEAEVKTIKPPPVEPEPTPIAAPVTVP 11051



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 104/452 (23%), Positives = 152/452 (33%), Gaps = 60/452 (13%)

Query: 660   IPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQE 719
             +P   K  AP +  P  P+ P    P L      P P       P+ P  P     P ++
Sbjct: 9965  VPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKV----PEVPKKP----VPEEK 10016

Query: 720   SPV-ISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPE 778
              PV + K    PP+  P     P P KK  V V AP   E             PP   PE
Sbjct: 10017 VPVPVPKKVEAPPAKVPEVPKKPVPEKK--VPVPAPKKVEA------------PPAKVPE 10062

Query: 779   EQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATAL---QIQPPGSPDP 835
                  + +   P      V +P P  P    E V  P A       L   +I P     P
Sbjct: 10063 VPKKLIPEEKKPTPVPKKVEAPPPKVPK-KREPVPVPVALPQEEEVLFEEEIVPEEEVLP 10121

Query: 836   PPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPRED--------VGAPLVTPSLLQMV 887
                   P      P     LP++E +   +   PP E+        V    V P +   V
Sbjct: 10122 EEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKV 10181

Query: 888   RLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGL 947
                    P  AP P +     +K +       A P   P   +   V  K   L   E +
Sbjct: 10182 -------PVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPE--VPKKVEEKRIILPKEEEV 10232

Query: 948   SSAQPNGPPEAEP----RPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAEL 1003
                +    PE EP      P+ P S          R  ++ +   PE    + + + A  
Sbjct: 10233 LPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPP 10292

Query: 1004  RSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEP---LTAPPTNGLPHTQD 1060
               +S++ P +      K P PV +K +   PP   P  P+  P   +  P    +P  + 
Sbjct: 10293 AKVSKKIPEE------KVPVPVQKKEA---PPAKVPEVPKKVPEKKVLVPKKEAVPPAKG 10343

Query: 1061  RTKRELAENGGVLQLVGPEEKMGLPGSDSQKE 1092
             RT  E   +    Q V  +E++ L   +++ E
Sbjct: 10344 RTVLEEKVSVAFRQEVVVKERLELEVVEAEVE 10375



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 95/386 (24%), Positives = 138/386 (35%), Gaps = 66/386 (17%)

Query: 718   QESPVISKDQSPPPSPPPSYHPPPP--------PTKKPEVVVEAPSASETAEEPLQDPNW 769
             +E  V  K ++PP  P  S    PP        P K+P   V         EE ++ P  
Sbjct: 10428 EEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEE 10487

Query: 770   PPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAG--PSGSPELVSSPAASSSSATALQI 827
             P  PP         + +  PP+E       P P    P   P  V            + +
Sbjct: 10488 PRVPP-------TKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPV 10540

Query: 828   QPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMV 887
              PP  P+ PP      P ++ P    K+P+  P    K   PP E   AP       ++V
Sbjct: 10541 PPPKKPEVPPTKVPEVPKAAVP--EKKVPEAIP---PKPESPPPEVPEAP------KEVV 10589

Query: 888   RLRSV-GAPGGAP--TPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAAS 944
               + V  AP   P  TP   P AP    +  +  +  PVP P        ++      A 
Sbjct: 10590 PEKKVPAAPPKKPEVTPVKVPEAP----KEVVPEKKVPVPPPKKPEVPPTKVPEVPKVA- 10644

Query: 945   EGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVS-----PETQADLQRNL 999
                        PEA P  P+SP      +F +   ++ LE P +     PE  A  Q  +
Sbjct: 10645 -----VPEKKVPEAIPPKPESPPPE---VFEE-PEEVALEEPPAEVVEEPEPAAPPQVTV 10695

Query: 1000  VAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQ 1059
                        PP+ P    KAP  VA+KP   +PP   P  P+           +P   
Sbjct: 10696 -----------PPKKPVPEKKAPAVVAKKPE--LPPVKVPEVPKEVVPEKKVPLVVPKKP 10742

Query: 1060  DRTKRELAENGGVLQLVGPEEKMGLP 1085
             +    ++ E   V + V PE+K+ +P
Sbjct: 10743 EAPPAKVPE---VPKEVVPEKKVAVP 10765



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 88/402 (21%), Positives = 137/402 (34%), Gaps = 49/402 (12%)

Query: 495   KRPPPPPRRTHSLHQRGLAVPDGPLG----LPPKPERKQQPQLPRPPTTGGSEGAGAAPC 550
             K+P P P++  +   +   VP  P      L PK E+    ++P  P     E     P 
Sbjct: 9962  KKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPV 10021

Query: 551   P-----PNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSS-------QSGTPTLPPKGL 598
             P     P      VP       + P  +P++  +P +           +   PT  PK +
Sbjct: 10022 PKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKV 10081

Query: 599   AGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRF 658
               PP    K + P P  V   +         +           P +   P+    L +  
Sbjct: 10082 EAPPPKVPKKREPVPVPVALPQEEEVLFEEEI----------VPEEEVLPEEEEVLPEEE 10131

Query: 659   VIPPHPK--VPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSP---PTPQTT 713
              + P  +  +P     PP +   P            VP      +  P+ P   P P+  
Sbjct: 10132 EVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIK 10191

Query: 714   LTPLQESPVISKDQSPPPSPPPSYHPPPPPTK-----KPEVVVEAPSASETAEEPLQDPN 768
                 ++  VI K +  PP+  P   P     K     K E V+      E  EEP+ +  
Sbjct: 10192 KKVTEKKVVIPKKEEAPPAKVPEV-PKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEE 10250

Query: 769   WPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQ 828
              P  PP   E ++++    PP        A PE   P+  P+ V +P A  S       +
Sbjct: 10251 IPEEPPSIEEVEEVA----PPRVPEVIKKAVPE--APTPVPKKVEAPPAKVSK------K 10298

Query: 829   PPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPP 870
              P    P P     AP +  P    K+P+K+ +   K   PP
Sbjct: 10299 IPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPP 10340



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 91/391 (23%), Positives = 123/391 (31%), Gaps = 62/391 (15%)

Query: 663  HPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQES-- 720
            H  +     PPP  P  P   AP   AP  +P  V      P +P  P+    P+ E   
Sbjct: 9275 HVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKV-----EPPAPKVPEVPKKPVPEEKK 9329

Query: 721  --PVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPE 778
              PV  K+ + PP  P     P P  K P  V +   A               PP   PE
Sbjct: 9330 PVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEA---------------PPAKVPE 9374

Query: 779  EQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPA 838
             Q   +      EE    V   E + P   PE+                 P    + PP 
Sbjct: 9375 VQKGVVT-----EEKITIVTQREESPPPAVPEIPKKKVPEERKPV-----PRKEEEVPPP 9424

Query: 839  PPAPA-PASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGG 897
            P  PA P    P     +    PV  +K   PPR +V    V      +   +       
Sbjct: 9425 PKVPALPKKPVPEEKVAV----PVPVAKKAPPPRAEVSKKTVVEEKRFVAEEK------- 9473

Query: 898  APTPALGPSAPQK--PLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGP 955
                 L  + PQ+    R  +S          S     V +        E    A+    
Sbjct: 9474 -----LSFAVPQRVEVTRHEVSAEEE---WSYSEEEEGVSISVYREEEREEEEEAEVT-E 9524

Query: 956  PEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAP 1015
             E    P +        I SK       E     E +  L+  + A++      + P+AP
Sbjct: 9525 YEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAP 9584

Query: 1016 KK---SPKAPPPVARKPSVGVPPPASPSYPR 1043
            KK     K P PV +K    VPPP  P  P+
Sbjct: 9585 KKIVPEKKVPAPVPKKEK--VPPPKVPEEPK 9613



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 100/439 (22%), Positives = 143/439 (32%), Gaps = 103/439 (23%)

Query: 662   PHPKVPAPFSPPPSKPRSPNPAAPALAAP-AVVPGPVSTTDASPQSPPTPQTTLTPLQES 720
             P P  P P  P P+KP++P       A P   VP P+      P  P  P+      +E 
Sbjct: 9792  PIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPI-PKKLKPPPPKVPEEPKKVFEEK 9850

Query: 721   PVIS--KDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPE 778
               IS  K +    + P +  P      KP+ VV    A E    P ++   P   P  P+
Sbjct: 9851  IRISITKREKEQVTEPAAKVP-----MKPKRVV----AEEKVPVPRKEVAPPVRVPEVPK 9901

Query: 779   EQDLSMADFPPPEEAFFS---VASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDP 835
             E +        PEE  F    V   E        E +          T  ++ P      
Sbjct: 9902  ELE--------PEEVAFEEEVVTHVEEYLVEEEEEYIHE---EEEFITEEEVVPVIPVKV 9950

Query: 836   PPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAP 895
             P  P  P P    P  V K  +  P    +    P E V  P++ P   +          
Sbjct: 9951  PEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKV--PVLIPKKEK---------- 9998

Query: 896   GGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGP 955
                P PA  P  P+KP+         PVP P                        +   P
Sbjct: 9999  ---PPPAKVPEVPKKPVPE----EKVPVPVPK-----------------------KVEAP 10028

Query: 956   PEAEPRPPQSPASTASFIFSKGSRKLQLERP----VSPETQADLQRNLVAELRSISEQRP 1011
             P   P  P+ P            +K+ +  P      P    ++ + L+ E     E++P
Sbjct: 10029 PAKVPEVPKKPVP---------EKKVPVPAPKKVEAPPAKVPEVPKKLIPE-----EKKP 10074

Query: 1012  PQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPL-----TAPPTNGLPHTQDRTKREL 1066
                PKK    PP V +K     P P   + P+ E +       P    LP  ++    E 
Sbjct: 10075 TPVPKKVEAPPPKVPKKRE---PVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEE- 10130

Query: 1067  AENGGVLQLVGPEEKMGLP 1085
                    + V PEE+  LP
Sbjct: 10131 -------EEVLPEEEEVLP 10142



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 55/204 (26%), Positives = 77/204 (37%), Gaps = 45/204 (22%)

Query: 640  PAPSDRSGPQILTPLG-DRFVIPPHPKVP-APFSP-PPSKPRSPNPAAPALAAPAV---- 692
            P   ++  P+ + P+   + V PP PKVP  P  P P  K   P P     A P V    
Sbjct: 9289 PELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVP 9348

Query: 693  --------VPGPVSTTDASPQS--PPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPP 742
                    +P PV+    +P +  P   +  +T  + + V  +++SPPP+ P       P
Sbjct: 9349 KKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEI-----P 9403

Query: 743  PTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEP 802
              K PE     P   E            PPPP  P     ++   P PEE    VA P P
Sbjct: 9404 KKKVPEERKPVPRKEEEV----------PPPPKVP-----ALPKKPVPEE---KVAVPVP 9445

Query: 803  AGPSGSPELVSSPAASSSSATALQ 826
                  P     P A  S  T ++
Sbjct: 9446 VAKKAPP-----PRAEVSKKTVVE 9464



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 76/348 (21%), Positives = 107/348 (30%), Gaps = 103/348 (29%)

Query: 724  SKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEE---------PLQDPNWPPPPP 774
            S ++  P   P    PPPP   K  V+ +    S   EE          +     P  P 
Sbjct: 9160 SHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPS 9219

Query: 775  PAPEEQDLSMADFPP--------PEEAFFSVASPEPAGPSGSPELVSSPAASSSSATAL- 825
              P ++++     P          EE  F  +  E       PE+            A+ 
Sbjct: 9220 RTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAIS 9279

Query: 826  -QIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLL 884
             +++PP  P  P  P  PAP   AP  + K  +           PP     AP V     
Sbjct: 9280 KRVEPP--PKVPELPEKPAPEEVAPVPIPKKVE-----------PP-----APKV----- 9316

Query: 885  QMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAAS 944
                                P  P+KP+         PVP P                  
Sbjct: 9317 --------------------PEVPKKPVPE----EKKPVPVPKK---------------- 9336

Query: 945  EGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAE-- 1002
                  +P  PP+  P  P+ P            +K   E P  P    ++Q+ +V E  
Sbjct: 9337 ------EPAAPPKV-PEVPKKPVPEEKIPVPVAKKK---EAP--PAKVPEVQKGVVTEEK 9384

Query: 1003 ---LRSISEQRPPQAP----KKSPKAPPPVARKPSVGVPPPASPSYPR 1043
               +    E  PP  P    KK P+   PV RK     PPP  P+ P+
Sbjct: 9385 ITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPK 9432



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 110/598 (18%), Positives = 171/598 (28%), Gaps = 125/598 (20%)

Query: 521   LPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSP 580
             +P K E     ++P  P     E    AP P       VP         PP+ PE    P
Sbjct: 9568  IPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEK---VP---------PPKVPEEPKKP 9615

Query: 581   SSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDP 640
                         +PPK +        K + P P +VT            L ++    + P
Sbjct: 9616  VP-------EKKVPPKVI--------KMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPP 9660

Query: 641   APSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVS-- 698
                    P+   P      + P  +   P      + R       ++ AP   P P+   
Sbjct: 9661  KARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEV 9720

Query: 699   TTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASE 758
             T     +   T +     +Q      + +         Y P     +  E         E
Sbjct: 9721  TIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYE 9780

Query: 759   TAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAAS 818
               EE + +P  P P  P PEE   +    PP +      A PE   P   P+ +  P   
Sbjct: 9781  EHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAK--VLKKAVPEEKVPVPIPKKLKPP--- 9835

Query: 819   SSSATALQIQPPGSPDPP---------------PAPPAPAPASSAPGHVAKLPQKEPVGC 863
                       PP  P+ P                      PA+  P    ++  +E V  
Sbjct: 9836  ----------PPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPV 9885

Query: 864   SKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPT----------------------- 900
                   PR++V  P+  P + + +    V       T                       
Sbjct: 9886  ------PRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITE 9939

Query: 901   ----PALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPP 956
                 P +    P+ P R+ +     PVP P                        +   PP
Sbjct: 9940  EEVVPVIPVKVPEVP-RKPVPEEKKPVPVPK-----------------------KKEAPP 9975

Query: 957   EAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSIS--EQRPPQA 1014
                P  P+ P      +  K  +    + P  P+     ++  V   + +     + P+ 
Sbjct: 9976  AKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEV 10035

Query: 1015  PKKS-PKAPPPVARKPSVGVPPPASPSYPR------AEPLTAPPTNGLPHTQDRTKRE 1065
             PKK  P+   PV     V  PP   P  P+       +P   P     P  +   KRE
Sbjct: 10036 PKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKRE 10093



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 32/105 (30%), Positives = 44/105 (41%), Gaps = 7/105 (6%)

Query: 664  PKVPAPFS-PPPSK-PRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESP 721
            PK+PA    PPP+K P +P    P    PA  P P       P+ P  P+  +   +  P
Sbjct: 9566 PKIPAKIEEPPPAKVPEAPKKIVPEKKVPA--PVPKKEKVPPPKVPEEPKKPVPEKKVPP 9623

Query: 722  VISKDQSPPPSPPPSYHPPPPPTKKPEVVV---EAPSASETAEEP 763
             + K + P P+     H      +K  V V   EAP  +   EEP
Sbjct: 9624 KVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEP 9668



 Score = 38.1 bits (87), Expect = 0.046
 Identities = 76/377 (20%), Positives = 124/377 (32%), Gaps = 55/377 (14%)

Query: 531  PQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGT 590
            P++P  P     E     P P                +  P +P+    P      +   
Sbjct: 9286 PKVPELPEKPAPEEVAPVPIP---------------KKVEPPAPKVPEVPKKPVPEEKKP 9330

Query: 591  PTLPPKGLAGPPASPGKAQPPKPER------VTSLRSPGASV---------SSSLTSLCS 635
              +P K  A PP  P   + P PE            +P A V            +T +  
Sbjct: 9331 VPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQ 9390

Query: 636  SSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPG 695
                P P+    P+   P   +    P P+      PPP  P  P    P       VP 
Sbjct: 9391 REESPPPAVPEIPKKKVPEERK----PVPRKEEEVPPPPKVPALPKKPVP--EEKVAVPV 9444

Query: 696  PVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPS 755
            PV+     P++  + +T    ++E   +++++           P      + EV  E   
Sbjct: 9445 PVAKKAPPPRAEVSKKTV---VEEKRFVAEEKL------SFAVPQRVEVTRHEVSAEEEW 9495

Query: 756  ASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSP 815
            +    EE +    +        EE++  + ++   EE    V   E      S  + + P
Sbjct: 9496 SYSEEEEGVSISVY--REEEREEEEEAEVTEYEVMEEPEEYVV--EEKLHIISKRVEAEP 9551

Query: 816  AASSSSATALQIQPPGSP----DPPPAPPAPAPASSAPGH--VAKLPQKEPVGCSKGGGP 869
            A  +       +  P  P    +PPPA    AP    P     A +P+KE V   K    
Sbjct: 9552 AEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEE 9611

Query: 870  PREDVGAPLVTPSLLQM 886
            P++ V    V P +++M
Sbjct: 9612 PKKPVPEKKVPPKVIKM 9628



 Score = 37.0 bits (84), Expect = 0.10
 Identities = 35/107 (32%), Positives = 44/107 (41%), Gaps = 16/107 (14%)

Query: 955  PPEAEPRPPQSPA--STASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPP 1012
            PP   P  P+ PA    A     K   K++   P  PE    + +  V E     E++P 
Sbjct: 9284 PPPKVPELPEKPAPEEVAPVPIPK---KVEPPAPKVPE----VPKKPVPE-----EKKPV 9331

Query: 1013 QAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQ 1059
              PKK P APP V   P   VP    P  P A+   APP   +P  Q
Sbjct: 9332 PVPKKEPAAPPKVPEVPKKPVPEEKIP-VPVAKKKEAPPAK-VPEVQ 9376



 Score = 35.8 bits (81), Expect = 0.23
 Identities = 38/115 (33%), Positives = 49/115 (42%), Gaps = 26/115 (22%)

Query: 662 PHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESP 721
           PH K P P  PP  K RSP P  P++AA A +        A  QSP       +P++ SP
Sbjct: 250 PH-KTP-PRIPPKPKSRSPTP--PSIAAKAQL--------ARQQSP-------SPIRHSP 290

Query: 722 -VISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAP------SASETAEEPLQDPNW 769
             +   ++P PSP  S  P    +  P   V +P       AS  A  P   P W
Sbjct: 291 SPVRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKTQASTVATGPEVPPPW 345



 Score = 35.0 bits (79), Expect = 0.39
 Identities = 28/105 (26%), Positives = 38/105 (36%), Gaps = 10/105 (9%)

Query: 662  PHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPL---- 717
            P  +VP P  P  + P    P   A   P ++P P        + PP  +  +T      
Sbjct: 8938 PDSRVPIPTMPIRAVPPEEIPPVVAPPIPLLLPTP------EEKKPPPKRIEVTKKAVKK 8991

Query: 718  QESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEE 762
                V++K +   P       PPPP T  P    E    S  AEE
Sbjct: 8992 DAKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAPEIIDVSSKAEE 9036


>gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapiens]
          Length = 673

 Score =  113 bits (283), Expect = 9e-25
 Identities = 165/717 (23%), Positives = 257/717 (35%), Gaps = 111/717 (15%)

Query: 404  PRSRHPSSSSDTWSHSQSSDTIVSDGSTLS---SKGGSEGQPESSTASNSVVPPPQGGSG 460
            P +R PS +S T + S +S T     ++L+   S     G P  S AS +  PP     G
Sbjct: 3    PPTRTPSRASPTRTPSTASLTGTPSRASLTGTPSTASLMGTP--SRASLTGTPPRASLKG 60

Query: 461  RGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLG 520
              S +    + +  +L+   S  L  R+ S+  LKR PP   RT +L +  L        
Sbjct: 61   TTSMASLMVSPSRASLTRMQSSSLLTRTPSMASLKRMPPRASRTRTLPRASLMRRPSTAS 120

Query: 521  LPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSP 580
            L   P R      P   +   +    AA   P+ A+          +R PPR+   T++P
Sbjct: 121  LTRSPSRASLTTTPSRASLSMTPSTAAALTMPSRASL---------TRTPPRA-SLTMTP 170

Query: 581  SSGYSSQSGTPTLPPKGLAGPPASPGKAQP---PKPERVTSLRSPGASVSSSLTSLCSSS 637
            S+   +++     PP+  A P   P +  P   P    +T + S  AS++ +L+    + 
Sbjct: 171  STASLTRT-----PPR--ASPTGMPSRTSPTGMPSTASLTKMDST-ASITRTLSRASPTG 222

Query: 638  SDPAPSDRSGPQ----ILTPLGDRFVIPPHPKVP---------------APFSPPPSKPR 678
            + P  S    P      + P     +  P    P               A  +  PS+P 
Sbjct: 223  TPPRASPTGSPPRASLSMMPSTALLIRTPPRASPTGMLSRTSLTKMDSTASITRTPSRPS 282

Query: 679  SPNP-AAPALAAPAVVPGPVS-----------------------TTDASPQSPPTPQTTL 714
            + +P   P+ A+ ++ P   S                       +T +  ++PP    T 
Sbjct: 283  TASPTGTPSRASLSMTPSTASLMRMLPRASPTGMLSRTSLTKMDSTASISRTPPRASITR 342

Query: 715  TPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPP--- 771
            TP + SP   K  +  P+  PS   P        +   + +AS T   P   P   P   
Sbjct: 343  TPSRASPT-GKPSTASPTGTPSRASPTGSPSTASLTGLSSTASPTGTPPRASPTGTPSTA 401

Query: 772  ----PPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVS---SPAASSSSATA 824
                 PP A     LS       +       +P  A P+G+P   S   +P+ +S + T 
Sbjct: 402  SLTRKPPRASPTGMLSRTSITKMDSTASPTRTPPRASPTGTPPRASPTGTPSRASPTGTQ 461

Query: 825  LQIQPPGSPD--PPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPS 882
                P GSP    P   P+ A  + +P   +          +K      E   +   TPS
Sbjct: 462  STASPTGSPSTASPTGSPSTASPTGSPSRASLTRTPSRASLTK-----MESTASITRTPS 516

Query: 883  LLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPS-SGLHAAVRLKACSL 941
                    S  +P G+P+ AL   +P +        RAS    PS + L    R      
Sbjct: 517  RASPTWTPSTASPTGSPSTALAMGSPSRAALTRTPSRASLTRTPSRASLTTPSRASLTRT 576

Query: 942  AASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVA 1001
             ++  L+   P+  P   P         +S + +K      + R                
Sbjct: 577  PSTVLLTRMPPSASPTGMPSRTSPTGMPSSALLTKMDSTASITR---------------T 621

Query: 1002 ELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASP--SYPRAEPLTAPPTNGLP 1056
              R+   + PP+A   SP   PP  R    G PP ASP  + PRA P T  P+   P
Sbjct: 622  PPRASPTETPPRA---SPTGTPP--RASPTGTPPRASPTGTPPRASP-TGTPSRASP 672



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 150/682 (21%), Positives = 232/682 (34%), Gaps = 70/682 (10%)

Query: 234 GLRNEREAPGTPRAPGARDAVRIPTVDGRP-----RGTSGMGA------RVSLQALEAEA 282
           G  +     GTP            ++ G P     +GT+ M +      R SL  +++ +
Sbjct: 24  GTPSRASLTGTPSTASLMGTPSRASLTGTPPRASLKGTTSMASLMVSPSRASLTRMQSSS 83

Query: 283 E-AGAETEAMLQRHIDRVYRDDTFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAE----P 337
                 + A L+R   R  R  T    S   R    +   S +   LT     A     P
Sbjct: 84  LLTRTPSMASLKRMPPRASRTRTLPRASLMRRPSTASLTRSPSRASLTTTPSRASLSMTP 143

Query: 338 LSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFS 397
            + A    P    L++  P A L  T    +L R   R          SP  + S    +
Sbjct: 144 STAAALTMPSRASLTRTPPRASLTMTPSTASLTRTPPRASPTGMPSRTSPTGMPSTASLT 203

Query: 398 SVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGS--------EGQPESSTASN 449
            + S    +R  S +S T +  ++S T     ++LS    +           P    +  
Sbjct: 204 KMDSTASITRTLSRASPTGTPPRASPTGSPPRASLSMMPSTALLIRTPPRASPTGMLSRT 263

Query: 450 SVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQ 509
           S+       S   +PS  STA  + T S  S       +  +R L R  P    T  L +
Sbjct: 264 SLTKMDSTASITRTPSRPSTASPTGTPSRASLSMTPSTASLMRMLPRASP----TGMLSR 319

Query: 510 RGLAVPDGPLGL---PPKPERKQQPQLPRP---PTTGGSEGAGAAPCPP-NPANSWVPGL 562
             L   D    +   PP+    + P    P   P+T    G  +   P  +P+ + + GL
Sbjct: 320 TSLTKMDSTASISRTPPRASITRTPSRASPTGKPSTASPTGTPSRASPTGSPSTASLTGL 379

Query: 563 SPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSP 622
           S   S  P  +P R        +S +GTP+      A     P +A P      TS+   
Sbjct: 380 SSTAS--PTGTPPR--------ASPTGTPS-----TASLTRKPPRASPTGMLSRTSITKM 424

Query: 623 GASVSSSLTSLCSS--SSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSP 680
            ++ S + T   +S   + P  S    P   +P G +    P    P+  SP  S   + 
Sbjct: 425 DSTASPTRTPPRASPTGTPPRASPTGTPSRASPTGTQSTASPTGS-PSTASPTGSPSTAS 483

Query: 681 NPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPP 740
              +P+ A+    P   S T    +   T   T TP + SP  +   + P   P +    
Sbjct: 484 PTGSPSRASLTRTPSRASLT----KMESTASITRTPSRASPTWTPSTASPTGSPSTALAM 539

Query: 741 PPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASP 800
             P++    +   PS +     P +     P            +    PP  +      P
Sbjct: 540 GSPSR--AALTRTPSRASLTRTPSRASLTTPSRASLTRTPSTVLLTRMPPSAS--PTGMP 595

Query: 801 EPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEP 860
               P+G P   SS   +   +TA   + P    P   PP  +P  + P      P   P
Sbjct: 596 SRTSPTGMP---SSALLTKMDSTASITRTPPRASPTETPPRASPTGTPP---RASPTGTP 649

Query: 861 VGCSKGGGPPREDVGAPLVTPS 882
              S  G PPR    +P  TPS
Sbjct: 650 PRASPTGTPPR---ASPTGTPS 668



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 102/418 (24%), Positives = 155/418 (37%), Gaps = 79/418 (18%)

Query: 337 PLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRF 396
           P   ++S++P    L +++P A   PT     L R SL  +   +  S +P    S+ R 
Sbjct: 290 PSRASLSMTPSTASLMRMLPRA--SPTG---MLSRTSLTKMDSTASISRTPPRA-SITRT 343

Query: 397 SSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQ 456
            S +SP  +   PS++S T + S++S T     ST S  G       SSTAS +  PP  
Sbjct: 344 PSRASPTGK---PSTASPTGTPSRASPT--GSPSTASLTG------LSSTASPTGTPPR- 391

Query: 457 GGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPP--PPRRTHSLHQRGLAV 514
             S  G+PS  S        S   +G LS  S++       P   PPR +          
Sbjct: 392 -ASPTGTPSTASLTRKPPRAS--PTGMLSRTSITKMDSTASPTRTPPRAS---------- 438

Query: 515 PDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPP--R 572
              P G PP+      P    P  T  +     +P   +P  S       G   R    R
Sbjct: 439 ---PTGTPPRASPTGTPSRASPTGTQSTASPTGSPSTASPTGSPSTASPTGSPSRASLTR 495

Query: 573 SPER------------TLSPSSG---YSSQSGTPT-LPPKGLA-GPPA------------ 603
           +P R            T +PS     ++  + +PT  P   LA G P+            
Sbjct: 496 TPSRASLTKMESTASITRTPSRASPTWTPSTASPTGSPSTALAMGSPSRAALTRTPSRAS 555

Query: 604 ---SPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPA---PSDRSGPQILTPLGDR 657
              +P +A    P R +  R+P   + + +    S +  P+   P+      +LT +   
Sbjct: 556 LTRTPSRASLTTPSRASLTRTPSTVLLTRMPPSASPTGMPSRTSPTGMPSSALLTKMDST 615

Query: 658 FVIPPHPKVPAPFSPPP------SKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPT 709
             I   P   +P   PP      + PR+     P  A+P   P   S T    ++ PT
Sbjct: 616 ASITRTPPRASPTETPPRASPTGTPPRASPTGTPPRASPTGTPPRASPTGTPSRASPT 673



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 113/502 (22%), Positives = 164/502 (32%), Gaps = 106/502 (21%)

Query: 570  PPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSS 629
            P R+P R  SP+   S+ S T T     L G P++      P    +T    P AS+  +
Sbjct: 4    PTRTPSRA-SPTRTPSTASLTGTPSRASLTGTPSTASLMGTPSRASLTGT-PPRASLKGT 61

Query: 630  LTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAA 689
             TS+ S    P+ +  +  Q  + L     +    ++P   S   + PR+     P+ A+
Sbjct: 62   -TSMASLMVSPSRASLTRMQSSSLLTRTPSMASLKRMPPRASRTRTLPRASLMRRPSTAS 120

Query: 690  PAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEV 749
                P   S T     +P     ++TP   + +    ++     PP          +  +
Sbjct: 121  LTRSPSRASLTT----TPSRASLSMTPSTAAALTMPSRASLTRTPP----------RASL 166

Query: 750  VVEAPSASETAEEPLQDPNWPPP---PPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPS 806
             +   +AS T   P   P   P    P   P    L+  D         S ASP    P 
Sbjct: 167  TMTPSTASLTRTPPRASPTGMPSRTSPTGMPSTASLTKMDSTASITRTLSRASPTGTPPR 226

Query: 807  GSPELVSSPAASSSS--ATALQIQPPGSPDPPPAPPAPAPASS-----APGHVAKLPQKE 859
             SP   S P AS S   +TAL I+ P    P  +P      +S     +   + + P + 
Sbjct: 227  ASPT-GSPPRASLSMMPSTALLIRTP----PRASPTGMLSRTSLTKMDSTASITRTPSR- 280

Query: 860  PVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGR 919
            P   S  G P R  +    +TPS   ++R+     P  +PT  L  ++  K    A   R
Sbjct: 281  PSTASPTGTPSRASLS---MTPSTASLMRM----LPRASPTGMLSRTSLTKMDSTASISR 333

Query: 920  ASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSR 979
              P                   + +   S A P G P        SP  T S     GS 
Sbjct: 334  TPP-----------------RASITRTPSRASPTGKPSTA-----SPTGTPSRASPTGS- 370

Query: 980  KLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASP 1039
                     P T         A L  +S    P                   G PP    
Sbjct: 371  ---------PST---------ASLTGLSSTASP------------------TGTPP---- 390

Query: 1040 SYPRAEPLTAPPTNGLPHTQDR 1061
               RA P   P T  L     R
Sbjct: 391  ---RASPTGTPSTASLTRKPPR 409


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score =  112 bits (279), Expect = 2e-24
 Identities = 155/600 (25%), Positives = 222/600 (37%), Gaps = 84/600 (14%)

Query: 466  GGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVP---DGPLG-- 520
            G +  +  D L +   GQ  G  V+  + K P P       L + G+ +    + PL   
Sbjct: 378  GDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEAPLNEE 437

Query: 521  ---LPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPN-PANSWVPGLSPGGSRRPPRSPER 576
               LPP  E    P     PT+   E +  +P P   PA+     L    SR    SP  
Sbjct: 438  MPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHL--SRPLEESP-- 493

Query: 577  TLSPSSGYSSQSGTPTLPP-KGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCS 635
             LSP    S  S  P   P   L   P SP +  PP P   T L  P             
Sbjct: 494  -LSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPP------------P 540

Query: 636  SSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPG 695
             +S  +P     P  L+P  +     P P+      PP   P SP P    ++ P     
Sbjct: 541  EASPLSPPFEESP--LSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASR 598

Query: 696  PVSTTDASPQSPPTPQTTLTPLQESPVIS-KDQSPPPSPPPSYHPPPPPTKKPEV--VVE 752
                 + SP SPP  ++ L+P  E+  +S   +  P SPPP   P  PP   PEV  +  
Sbjct: 599  LFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPP---PEVSRLSP 655

Query: 753  APSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELV 812
             P  S  +  P + P  PP     PEE   S    PPPE    S  SP P     SP   
Sbjct: 656  LPVVSRLSPPPEESPLSPP-----PEESPTS----PPPEA---SRLSPPPEDSPTSPPPE 703

Query: 813  SSPAASSSSATALQIQPPGSP-DPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPR 871
             SPA+     + + +    SP  P P  P   P S  P H++  P++  +        PR
Sbjct: 704  DSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGP-HLSPRPEEPHLS-------PR 755

Query: 872  EDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLH 931
             +   P ++P                A  P L P  P++P   A+       P  + G H
Sbjct: 756  PE--EPHLSPQ---------------AEEPHLSPQ-PEEPCLCAVPEEPHLSP-QAEGPH 796

Query: 932  AAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPET 991
             + + +   L+      + +P+  P  E  P  SP    S +  +        RP     
Sbjct: 797  LSPQPEELHLSP----QTEEPHLSPVPE-EPCLSPQPEESHLSPQSEEPCLSPRPEESHL 851

Query: 992  QADLQRNLVAELRSISEQRPPQ--APKKSPKAPPP--VARKPSVGVPPPASPSYPRAEPL 1047
              +L++  ++       + P Q  AP++ P  PPP   +  P +G P  + P  P   PL
Sbjct: 852  SPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPL 911



 Score =  109 bits (273), Expect = 1e-23
 Identities = 163/655 (24%), Positives = 226/655 (34%), Gaps = 90/655 (13%)

Query: 442  PESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPP 501
            PE+S  S    PPP+       P     +   +   +     +S  S    +    PPP 
Sbjct: 621  PEASRLS----PPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPE 676

Query: 502  RRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPG 561
                S       +   P   P  P  +  P  P P  +  S     +P  P P     P 
Sbjct: 677  ESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEE---PQ 733

Query: 562  LSPG--GSRRPPRSPERTLSP---SSGYSSQSGTPTLPPKGLAGPPASPGK-AQPPKPER 615
            L P   G    PR  E  LSP       S Q+  P L P+     P  P   A P +P  
Sbjct: 734  LCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQ-----PEEPCLCAVPEEPHL 788

Query: 616  VTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPS 675
                  P  S       L   + +P  S       L+P  +   + P  + P     P  
Sbjct: 789  SPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEE 848

Query: 676  KPRSPN----PAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPP 731
               SP     P +P    P   PG     +  P  PP  + +L+PL   P +S+   PP 
Sbjct: 849  SHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPL 908

Query: 732  SPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPP- 790
            SP P   P  P                 + EP   P   PP P  P    +  A  PP  
Sbjct: 909  SPLPEELPLSP-----------------SGEPSLSPQLMPPDPLPPPLSPIITAAAPPAL 951

Query: 791  ------EEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQP---------PGSPDP 835
                  E  F +    +P  P  +P ++ +P +    A     +P         PGSP  
Sbjct: 952  SPLGELEYPFGAKGDSDPESPLAAP-ILETPISPPPEANCTDPEPVPPMILPPSPGSPVG 1010

Query: 836  PPAP----PAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRS 891
            P +P    P P   S    H        P  CS    PP      PL  PS L  +  + 
Sbjct: 1011 PASPILMEPLPPQCSPLLQHSLVPQNSPPSQCS----PP----ALPLSVPSPLSPIG-KV 1061

Query: 892  VGAPGGAPTPALGPSAPQKPLRRALSGRA-SPVPAPSSGLHAAVRLKACSLAASEGL--S 948
            VG    A    +      +P   AL   A SP+P+P   L       A +L    GL   
Sbjct: 1062 VGVSDEAELHEMETEKVSEPECPALEPSATSPLPSPMGDLSCPAPSPAPALDDFSGLGED 1121

Query: 949  SAQPNG--PPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSI 1006
            +A  +G   P ++P P Q+P S AS +  KGS  L     ++P T  +    +  E +  
Sbjct: 1122 TAPLDGIDAPGSQPEPGQTPGSLASEL--KGSPVLLDPEELAPVTPME----VYPECKQT 1175

Query: 1007 SEQRPPQAPKKSPKAP----PPVARKPSVG------VPPPASPSYPRAEPLTAPP 1051
            + Q  P   ++ P+AP    PP   K  +           AS S+P +EPL   P
Sbjct: 1176 AGQGSPCEEQEEPRAPVAPTPPTLIKSDIVNEISNLSQGDASASFPGSEPLLGSP 1230



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 178/736 (24%), Positives = 250/736 (33%), Gaps = 161/736 (21%)

Query: 437  GSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGR-SVSLRKLK 495
            G+ G P  + A    +  P       +P+G ST+  +D      +G + G  S     LK
Sbjct: 2111 GALGSPPPAAAPTIFIGSPT------TPAGLSTS--ADGFLKPPAGSVPGPDSPGELFLK 2162

Query: 496  RPPPPPRRTHSLHQRGLA--------VPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGA 547
             PP  P +  S    GLA         P  P   PP P     P   +PP  G S   GA
Sbjct: 2163 LPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPA--QPPMLGASSRPGA 2220

Query: 548  APCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGK 607
                P   ++      PG  R  P +P+  L P          P  P  G  G  + P  
Sbjct: 2221 GQ--PGEFHT----TPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVG-GGKASEPLL 2273

Query: 608  AQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQI--------------LTP 653
            + PP  E   +L      + +S  S    +     S  SG  +              LTP
Sbjct: 2274 SPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTP 2333

Query: 654  -----------LGDRFVIPP-----------HPKV------PAPFSPPPSKPRSPNPAAP 685
                       LG R   PP           HP +        P++ PP  PR P P  P
Sbjct: 2334 RASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPR-PQPPPP 2392

Query: 686  ----ALAAPAVVPGPVSTTDASPQSPPTPQTTLTP-------LQESPVISKDQSP----- 729
                AL   ++   P S   ASPQS  + Q+ LTP          SPV  + QSP     
Sbjct: 2393 ESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSR 2452

Query: 730  PPSPPPSYHP-----PPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSM 784
            PPS P S  P      PP  + PEV  +A S + T+   L    +P   P          
Sbjct: 2453 PPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTS---LGAGGFPAALPAG-------- 2501

Query: 785  ADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQ---PPGSPDPPPAPPA 841
                P  E    V S +P      P  V SP   +   T   ++   P    +P   PP 
Sbjct: 2502 ----PAGELHAKVPSGQP------PNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPV 2551

Query: 842  PAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTP 901
            P P          LP    +    G GP    +G P  T   +        G+P G  + 
Sbjct: 2552 PQPG---------LPPPHGINSHFGPGP---TLGKPQSTNYTVATGNFHPSGSPLGPSSG 2599

Query: 902  ALGPSAPQKPLRRALSGRASPVPAPSSGL----HAAVRLKACS--LAASEGLSSAQPNGP 955
            + G S    PLR        P PAP   L    H A +    +  +   E   +   +  
Sbjct: 2600 STGESYGLSPLR---PPSVLPPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSL 2656

Query: 956  PEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQR----- 1010
              AE    Q P   +    ++  ++ Q +R      +  +QRN + + +  +        
Sbjct: 2657 ATAELPGTQDP-GMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVG 2715

Query: 1011 PPQAPKKSPKAP---------PPVA----RKPSVGVPPP-------ASPSYPRAEPLTAP 1050
            PP +    P +P          P A    +   VG+PP           S+P  + L+ P
Sbjct: 2716 PPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRP 2775

Query: 1051 PTNGLPHTQDRTKREL 1066
            P    P + D   R+L
Sbjct: 2776 PPPATPSSMDVNSRQL 2791



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 116/430 (26%), Positives = 157/430 (36%), Gaps = 104/430 (24%)

Query: 657  RFVIPPHPKVPAPFSPP-PSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLT 715
            R V   H  V + FSPP P    +  P A  +A      G    T   P+ P   Q    
Sbjct: 359  RSVAEQHTPVCSRFSPPEPGDTPTDEPDALYVACQGQPKGG-HVTSMQPKEPGPLQCEAK 417

Query: 716  PL----------------QESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASET 759
            PL                +E P++   +  P SPPP   P  PP   PE    +P   E 
Sbjct: 418  PLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPP---PEASRLSPPPEEL 474

Query: 760  AEEPLQD------PNWPPPPPPAPEEQDLSMADFPPPEEAFFS------VASPEPAGPSG 807
               PL +      P    P  P PEE  LS    PPPE + FS      ++ PE + PS 
Sbjct: 475  PASPLPEALHLSRPLEESPLSPPPEESPLS----PPPESSPFSPLEESPLSPPEESPPSP 530

Query: 808  SPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGG 867
            + E   SP   +S  +    + P SP P   P +P P +S    ++  P++ P+      
Sbjct: 531  ALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEAS---RLSPPPEESPMS----- 582

Query: 868  GPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPS 927
             PP E   +P    S L          P    +P L P   + PL        SP P   
Sbjct: 583  PPPEESPMSPPPEASRL---------FPPFEESP-LSPPPEESPL--------SPPP--- 621

Query: 928  SGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPV 987
                     +A  L+     S   P  PPE  P  P    S  S         L +   +
Sbjct: 622  ---------EASRLSPPPEDSPMSP--PPEESPMSPPPEVSRLS--------PLPVVSRL 662

Query: 988  SPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAE-- 1045
            SP  +              S   PP  P++SP +PPP A +  +  PP  SP+ P  E  
Sbjct: 663  SPPPEE-------------SPLSPP--PEESPTSPPPEASR--LSPPPEDSPTSPPPEDS 705

Query: 1046 PLTAPPTNGL 1055
            P + PP + L
Sbjct: 706  PASPPPEDSL 715



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 167/717 (23%), Positives = 221/717 (30%), Gaps = 151/717 (21%)

Query: 328  LTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCSLRTLSRCSLHSASP 387
            LT  A   EP SP + + PQ             PP    +A    S   + R   ++  P
Sbjct: 2331 LTPRASQVEPQSPGLGLRPQE------------PPPAQALAPSPPSHPDIFRPGSYT-DP 2377

Query: 388  ASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTA 447
             +   L       +P+P+   P S       S  SD                  P+S ++
Sbjct: 2378 YAQPPL-------TPRPQPPPPESCCALPPRSLPSDPF----------SRVPASPQSQSS 2420

Query: 448  SNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRS--VSLRKLKRPPPPPR--R 503
            S S + P    +    PS  +    S     R   +   R     L K  RP PP    +
Sbjct: 2421 SQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFK 2480

Query: 504  THSLHQRGLAVPDGPLGLPPKPERKQQPQLP--RPPTTGGSEGAGAAPCPPNPANSWVPG 561
              SL    L     P  LP  P  +   ++P  +PP    S G GA    P+P     P 
Sbjct: 2481 AGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQ 2540

Query: 562  LSPGGSRRPPRSPERTLSPSSGYSSQ------------------------SGTPTLPPKG 597
                 S +PP  P+  L P  G +S                         SG+P  P  G
Sbjct: 2541 AVGEPSLKPP-VPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSG 2599

Query: 598  LAG------PPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQIL 651
              G      P   P    PP P+      S GAS  S +TS      DP           
Sbjct: 2600 STGESYGLSPLRPPSVLPPPAPDGSLPYLSHGASQRSGITSPVEKREDPG---------- 2649

Query: 652  TPLGDRFVIPPHPKVPAPFSPPPS-----KPRSPNPAAPAL-----------------AA 689
            T +G        P    P     S     K R        L                 AA
Sbjct: 2650 TGMGSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAA 2709

Query: 690  PAVVPGPVSTTDASPQSPPTPQTTL--TPLQESPVISKDQSPPPSP-------PPSYHP- 739
             A   GP  +  A P SP   Q +   TP   +   S     PPS        P S+   
Sbjct: 2710 AAGAVGPPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSD 2769

Query: 740  -----PPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDL---SMADFPPPE 791
                 PPPP     + V +      ++   Q   +P   P   ++Q L     A      
Sbjct: 2770 DRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQQQATAATSM 2829

Query: 792  EAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGH 851
                S   P   GP    + + SP A  S+    ++  PG P P PA PA          
Sbjct: 2830 RFAMSARFPSTPGPELGRQALGSPLAGIST----RLPGPGEPVPGPAGPA---------Q 2876

Query: 852  VAKLPQKEPVGCSKGG------GPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGP 905
              +L      G   GG      GPP+     P   P      RL    AP G    A+  
Sbjct: 2877 FIELRHNVQKGLGPGGTPFPGQGPPQR----PRFYPVSEDPHRL----APEGLRGLAVSG 2928

Query: 906  SAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRP 962
              PQKP        A P P  ++ LH     K  +L     L +  P+      P P
Sbjct: 2929 LPPQKP-------SAPPAPELNNSLHPTPHTKGPTLPTGLELVNRPPSSTELGRPNP 2978



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 95/383 (24%), Positives = 136/383 (35%), Gaps = 84/383 (21%)

Query: 733  PPPSYHPPPPPTKKPEVVVEAPSA----SETAEEPLQDPNWPPPPPPAPEEQDLSMADFP 788
            P P     PPP   P + + +P+     S +A+  L+ P    P P +P E  L +   P
Sbjct: 2108 PQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKL---P 2164

Query: 789  PPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSA 848
            P   A   V S +P G                 A A  ++P     PP  PP P+P + A
Sbjct: 2165 PQVPA--QVPSQDPFG----------------LAPAYPLEPRFPTAPPTYPPYPSP-TGA 2205

Query: 849  PGHVAKLPQKEPVGCSKGG-------GPPREDVGAPLV-----TPSLLQMVRLRSVGAPG 896
            P     L      G  + G       G PR     P        PSL  +    S G  G
Sbjct: 2206 PAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGG 2265

Query: 897  GAPTPALGPSAPQKPLRRALS------GRASP---------VPAPSSGLH---------- 931
            G  +  L    P    R+AL       G +SP         V +PSSG H          
Sbjct: 2266 GKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPD 2325

Query: 932  ---AAVRLKACSLAASEGLSSAQPNGPPEAE---PRPPQSPASTASFIFSKGS-RKLQLE 984
               A +  +A  +         +P  PP A+   P PP  P      IF  GS      +
Sbjct: 2326 VFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPD-----IFRPGSYTDPYAQ 2380

Query: 985  RPVSPETQADLQRNLVA----ELRSISEQRPPQAPKKSPKAPPPVARKP---SVGVPPPA 1037
             P++P  Q     +  A     L S    R P +P+    +  P+  +P       P P 
Sbjct: 2381 PPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPV 2440

Query: 1038 SPSYPRAEPLTAPPTNGLPHTQD 1060
            +P +   +P + PP+   P ++D
Sbjct: 2441 TPRFQSPDPYSRPPSR--PQSRD 2461



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 170/712 (23%), Positives = 246/712 (34%), Gaps = 134/712 (18%)

Query: 383  HSASPASVRSLGRFSSVSSPQPRSRHPSSSSD-TWSHSQSSDTIVSDGSTLSSKGGSEGQ 441
            H +SP +   LG    ++  +  +  P+ SS+ T   S      ++ G+T  S     G+
Sbjct: 4008 HFSSPGA---LGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGE 4064

Query: 442  PESSTASNSVV------PPPQGGSGRGSPSGGSTAEASDTLSIR------SSGQLSGRSV 489
             + S + +S +      P PQ  S +  P      +    +S+       S GQL   S 
Sbjct: 4065 VKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSS 4124

Query: 490  SLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAP 549
            S  +    P      H L Q  +++ D P  +       QQP L RP         G  P
Sbjct: 4125 S--EASSVP------HLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPM----QNNTGPQP 4172

Query: 550  CPPNPANSWVPGLSPGGSRRPP-------------RSPE-RTLSPSSGYSSQSGTPTLPP 595
              P P      GL PG    P              ++P+ R LSP      Q+    L  
Sbjct: 4173 PKPGPVLQSGQGL-PGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQA---LLMQ 4228

Query: 596  KGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSL-CSSSSDPAPSDRSGPQILTPL 654
            + L    A   +  PP  E       PG   S     L C       P  ++GP  L  L
Sbjct: 4229 RQLQQSQAV--RQTPPYQE-------PGTQTSPLQGLLGCQPQLGGFPGPQTGP--LQEL 4277

Query: 655  GDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTL 714
            G      P P+ P         PR P P       P + P   +   +SPQ P  P    
Sbjct: 4278 G----AGPRPQGP---------PRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLP 4324

Query: 715  TPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDP--NWPPP 772
            +P  + P  ++ Q PP  P      P  PT +P     +P+A++ A+         W PP
Sbjct: 4325 SPSSQLP--TEAQLPPTHPGTP--KPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPP 4380

Query: 773  PPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQI--QPP 830
               A  ++    +  P   +       PE +  S   E    P A  + +   +   +P 
Sbjct: 4381 DNLAETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGEPI 4440

Query: 831  GSPDPPPAPPAPAPASSAPGHVA--KLPQKEPVGCSKGGGPP--REDVGAPLVTPSLLQM 886
            G+P          P S A GH+   KL + + V  S G G    R ++   +   S L  
Sbjct: 4441 GAPGTSNHLLLAGPRSEA-GHLLLQKLLRAKNVQLSTGRGSEGLRAEINGHI--DSKLAG 4497

Query: 887  VRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRL--------KA 938
            +  +  G P          +A +KPL           P P     A+ RL        K 
Sbjct: 4498 LEQKLQGTPSNKED-----AAARKPL----------TPKPKRVQKASDRLVSSRKKLRKE 4542

Query: 939  CSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFI----FSKG---SRKLQLER------ 985
              + ASE L         E    P   PA TA+F     F  G   + + QL        
Sbjct: 4543 DGVRASEALLKQLKQ---ELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGA 4599

Query: 986  -PVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPP-VARKPSVGVPP 1035
             P  P+  + L       L   +   PP  P   P  PPP V +K   GV P
Sbjct: 4600 LPTGPDYYSQL-------LTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTP 4644



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 85/389 (21%), Positives = 124/389 (31%), Gaps = 68/389 (17%)

Query: 698  STTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSAS 757
            S T  SPQ     Q  L P   +  +    SP    P         T K +  V+   +S
Sbjct: 3981 SRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLL-----TGKEQNTVDPAVSS 4035

Query: 758  ETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAA 817
            E  E P      P      PE    SMA              P    PS           
Sbjct: 4036 EATEGPSTHQGGPLAIGTTPE----SMA------------TEPGEVKPS----------- 4068

Query: 818  SSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAP 877
             S  +  L +QP   P P P+     P    PG   +  Q   +  + GG   +   G+ 
Sbjct: 4069 LSGDSQLLLVQP--QPQPQPSSLQLQPPLRLPGQQQQ--QVSLLHTAGGGSHGQLGSGSS 4124

Query: 878  LVTPSLLQMVRLRSVGA---PGGAPTPALGPSAPQKPLRRALSGRASPVPA-PSSGLHAA 933
                S+  ++   SV     PG      LGP  P   L R +     P P  P   L + 
Sbjct: 4125 SEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPM--LERPMQNNTGPQPPKPGPVLQSG 4182

Query: 934  VRLKACSLAASEGLSSAQPNGP----PEAEPRPPQSPASTASFIFSKGSRKLQLERPVSP 989
              L    +  + G   AQ  G     P+     PQ      + +  +  ++ Q  R   P
Sbjct: 4183 QGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPP 4242

Query: 990  ETQADLQRNLV------------------AELRSISEQRPPQAPKKSPKAPPPVARKPSV 1031
              +   Q + +                    L+ +     PQ P + P  P  ++  P +
Sbjct: 4243 YQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVL 4302

Query: 1032 G----VPPPASPSYPRAEPLTAPPTNGLP 1056
            G     PPP+SP  P+       P++ LP
Sbjct: 4303 GPVHPTPPPSSPQEPKRPSQLPSPSSQLP 4331



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 86/394 (21%), Positives = 132/394 (33%), Gaps = 79/394 (20%)

Query: 720  SPVISKDQ-SPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPE 778
            S +++K+  S PP+PP S  P PPP+ + ++V     + E  E P            A  
Sbjct: 4608 SQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKD----------AAS 4657

Query: 779  EQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPA 838
             +D   A     E     + +  P  P    E V   +   S +            P   
Sbjct: 4658 ARDSERALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDS------------PDSI 4705

Query: 839  PPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGA 898
             PA +P S       + P           G  R +     ++P +  + R      P   
Sbjct: 4706 VPASSPESILGEEAPRFPHL---------GSGRWEQEDRALSPVIPLIPRASIPVFPDTK 4756

Query: 899  PTPALGPSAPQK-PLRRALSGRASPVPAPSSGLHAAVR-LKACSLAASEGLSSAQPNG-- 954
            P  ALG   P K P+     G+ S V    +   AA + L    +A +E LS   PN   
Sbjct: 4757 PYGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYE 4816

Query: 955  -------------PPEAEPRPP--------------------QSPASTASFIFSKGSRKL 981
                         P + E   P                    Q  A    +        L
Sbjct: 4817 VLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDIL 4876

Query: 982  QLERPVSPETQADLQRNLVAELRSISEQR----PPQ--APKKSPKAPPPVA--RKPSVGV 1033
             L +  SP  +   Q +    + ++  ++    PP+  +P  SP AP P +   +P V +
Sbjct: 4877 SLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVEL 4936

Query: 1034 P--PPASPSYPRAEPLTAPPTNGLPHTQDRTKRE 1065
            P  P A P  P   PL + P +  P  + R   E
Sbjct: 4937 PTEPLAEPPVPSPLPLASSPESARPKPRARPPEE 4970



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 102/434 (23%), Positives = 147/434 (33%), Gaps = 87/434 (20%)

Query: 315  PPLTRPMSLAVPGLTGGAGPA-EPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCS 373
            P L +P S      TG   P+  PL P+   + ++  LS L P +VLPP     +L   S
Sbjct: 2570 PTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPAPDGSLPYLS 2629

Query: 374  LRTLSRCSLHSASPASVR---SLGRFSSVSSPQ-PRSRHPSSS--SDTWSHSQ------- 420
                 R  +   SP   R     G  SS+++ + P ++ P  S  S T    Q       
Sbjct: 2630 HGASQRSGI--TSPVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLR 2687

Query: 421  --------SSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEA 472
                      +T+  +  T ++  G+ G P S  A  S   P      RG      T + 
Sbjct: 2688 ELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAEPS--SPAFEQLSRGQTPFAGTQDK 2745

Query: 473  SDTLSI---RSSGQL--SGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDG---------- 517
            S  + +   + SG +   G   S  +L RPPPP   + S+      +  G          
Sbjct: 2746 SSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPATPS-SMDVNSRQLVGGSQAFYQRAPY 2804

Query: 518  PLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERT 577
            P  LP + +++Q  Q  +         A +A  P  P               P    +  
Sbjct: 2805 PGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTPG--------------PELGRQAL 2850

Query: 578  LSPSSGYSSQSGTPTLPPKGLAGP------------------PASPGKAQPPKPERVTSL 619
             SP +G S++   P  P  G AGP                     PG+  P +P      
Sbjct: 2851 GSPLAGISTRLPGPGEPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRFYPVS 2910

Query: 620  RSPGASVSSSLTSLCSSSSDP-APSDRSGPQILTPLGDRFVIPPHPKVPA------PFSP 672
              P       L  L  S   P  PS    P++   L       PH K P         + 
Sbjct: 2911 EDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNSLHP----TPHTKGPTLPTGLELVNR 2966

Query: 673  PPSKPR--SPNPAA 684
            PPS      PNP A
Sbjct: 2967 PPSSTELGRPNPLA 2980



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 86/409 (21%), Positives = 124/409 (30%), Gaps = 91/409 (22%)

Query: 497  PPPPPRRTHSLHQRGLAVPDGPLGLPPKPE---RKQQPQLPRPPTTGGSEGAGAAPCPPN 553
            PP PP         G+  P   LG  PK     R  +  L         +   A P PP+
Sbjct: 4627 PPTPPPSVQQKMVNGVT-PSEELGEHPKDAASARDSERALRDTSEVKSLDLLAALPTPPH 4685

Query: 554  ---------------PANSWVPGLSPGG--SRRPPRSP----------ERTLSPSSGYSS 586
                             +S VP  SP        PR P          +R LSP      
Sbjct: 4686 NQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPHLGSGRWEQEDRALSPVIPLIP 4745

Query: 587  QSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRS 646
            ++  P  P      P  + G   P K    T  +  G+ VS  LT   +++ +      +
Sbjct: 4746 RASIPVFPD---TKPYGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAAAAKNLNGVMVA 4802

Query: 647  GPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALA----APAVVPGPVSTTDA 702
              ++L+           P+ PA     P K  +  P          +P   P  +   DA
Sbjct: 4803 VAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDA 4862

Query: 703  SPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEE 762
                   P  TL    +   + K +SP P PP  +      +      + AP   E    
Sbjct: 4863 V-----LPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEE---- 4913

Query: 763  PLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSA 822
                    P PPP+P                     +P PA P   P             
Sbjct: 4914 --------PSPPPSP--------------------LAPSPASPPTEP------------- 4932

Query: 823  TALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPR 871
                ++ P  P   P  P+P P +S+P      P+  P    +   PPR
Sbjct: 4933 ---LVELPTEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPR 4978



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 86/370 (23%), Positives = 127/370 (34%), Gaps = 58/370 (15%)

Query: 517  GPLGLPPKPERKQQ----PQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGS----- 567
            G   LP  P+   Q      L  PPT   S      P PP+     V G++P        
Sbjct: 4596 GSGALPTGPDYYSQLLTKNNLSNPPTPPSS--LPPTP-PPSVQQKMVNGVTPSEELGEHP 4652

Query: 568  --RRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGAS 625
                  R  ER L  +S   S      LP      PP +  + +  + E      SP + 
Sbjct: 4653 KDAASARDSERALRDTSEVKSLDLLAALPT-----PPHN--QTEDVRMESDEDSDSPDSI 4705

Query: 626  V-SSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSP--PPSKPRSPNP 682
            V +SS  S+    +   P   SG        DR + P  P +P    P  P +KP     
Sbjct: 4706 VPASSPESILGEEAPRFPHLGSGRW---EQEDRALSPVIPLIPRASIPVFPDTKPYG--- 4759

Query: 683  AAPALAAPAVVPG--PVSTTDASPQSPPTPQTTLTPLQ----ESPVISKDQSPPPSPPPS 736
                 A    VPG  PV+T +    S  +   T++          +++  +      P S
Sbjct: 4760 -----ALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNS 4814

Query: 737  YH------PPPPPTKKPEVVVEAPSASETAEE---PLQDPNWPPPPPPAPEEQDLSMADF 787
            Y       P    T+  +   E P   E   E   P   P+W        ++ D  +  +
Sbjct: 4815 YEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWL-------KQFDAVLPGY 4867

Query: 788  PPPEEA-FFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPAS 846
                +    S+   E   P    +   +   S+     L   PP  P PPP+P AP+PAS
Sbjct: 4868 TLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPAS 4927

Query: 847  SAPGHVAKLP 856
                 + +LP
Sbjct: 4928 PPTEPLVELP 4937



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 31/107 (28%), Positives = 40/107 (37%), Gaps = 19/107 (17%)

Query: 955  PPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQA 1014
            PPE  P  P   AS  S            E P SP  +A      +   R + E      
Sbjct: 452  PPEESPTSPPPEASRLS--------PPPEELPASPLPEA------LHLSRPLEESPLSPP 497

Query: 1015 PKKSPKAPPPVAR-----KPSVGVPPPASPSYPRAEPLTAPPTNGLP 1056
            P++SP +PPP +      + S   PP  SP  P  E   +PP    P
Sbjct: 498  PEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASP 544


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  110 bits (274), Expect = 9e-24
 Identities = 173/713 (24%), Positives = 241/713 (33%), Gaps = 146/713 (20%)

Query: 370  GRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDG 429
            GR ++   + C +H      +  + +   V  P    +      D  S   S  T  S G
Sbjct: 522  GRENILLCTDCRIHFKKYGELPPIEK--PVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRG 579

Query: 430  STLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSV 489
            S  + + G + QP S     S +      SGR SPS  ST          SS      +V
Sbjct: 580  SMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAAST----------SSNDSKAETV 629

Query: 490  --SLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGA 547
              S +K+K     P +++   QR     D         ++ +  ++ RP           
Sbjct: 630  KKSAKKVKEEASSPLKSNK-RQREKVASDTEEADRTSSKKTKTQEISRPN---------- 678

Query: 548  APCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGK 607
                                           SPS G    S + ++  +G + P      
Sbjct: 679  -------------------------------SPSEGEGESSDSRSVNDEGSSDPK----- 702

Query: 608  AQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVP 667
                       +     S S S+ S   + SD   SD S  Q +       +  P    P
Sbjct: 703  ----------DIDQDNRSTSPSIPSPQDNESD---SDSSAQQQMLQAQPPALQAPTGVTP 749

Query: 668  APFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSP--PTPQTTLTPLQESPVISK 725
            AP S PP  P+ P P  P  +A AV P    T   +P  P  PT     T +Q++P +  
Sbjct: 750  APSSAPPGTPQLPTPG-PTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHP 808

Query: 726  DQSPPPSPPPSYHPPPPPTKKPEV-VVEAPSASETAEEPLQDPNWPPPPPPAPEE-QDLS 783
             + P P PPP  HP P P  +P       PSA   A+ PL         PP P   Q   
Sbjct: 809  QRPPSPHPPP--HPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQG-----PPGPHSLQAGP 861

Query: 784  MADFPPPEEAFFSVASPEPAGPSGSPELVSSPAAS--------SSSATALQIQPPGSPDP 835
            +   P P + F       P    G   L +SPAA+         +S +ALQ Q P    P
Sbjct: 862  LLQHPGPPQPF----GLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQP 917

Query: 836  -PPAPPA-----PAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRL 889
             PPAP A     P P +  P   A    K P   S   GP    + A L  P  L+ +  
Sbjct: 918  LPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLS---GPSPFSMNANLPPPPALKPLSS 974

Query: 890  RSVGAPGGAPTPALG--------PSAPQKPLRRALSGRASPVPA--PSSGLHAAVRLKAC 939
             S   P  A  P L         PS+P +P     S    P PA  P +GLH        
Sbjct: 975  LSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPF 1034

Query: 940  SLAASEGLSSAQPNGPPEAEP-------RPPQSPASTASFIFSKGSRKLQLERPVSPETQ 992
            +           P GPP   P        PP  P ++A    S  +            + 
Sbjct: 1035 AQ------HPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAA-----------SG 1077

Query: 993  ADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPS-----VGVPPPASPS 1040
              +       L ++  +       + P++PPP  R PS     V  P  AS S
Sbjct: 1078 GSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQS 1130



 Score =  105 bits (263), Expect = 2e-22
 Identities = 182/773 (23%), Positives = 259/773 (33%), Gaps = 148/773 (19%)

Query: 370  GRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRS-----------RHPSSSSDTWSH 418
            G+ S+RT         S +++RS GR    +SP  R+           R+  S++ T S+
Sbjct: 568  GKHSMRTRRS----RGSMSTLRS-GRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSN 622

Query: 419  SQSSDTIVSDGSTLSSKGGSE------------GQPESSTASNSVVPPPQGGSGRGSPSG 466
               ++T+      +  +  S                E +  ++S     Q  S   SPS 
Sbjct: 623  DSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSE 682

Query: 467  GSTAEASDTLSIRSSGQLSGRSVSLRKLKRPP--PPPRRTHS---------LHQRGLAVP 515
            G   E+SD+ S+   G    + +        P  P P+   S         + Q      
Sbjct: 683  GE-GESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPAL 741

Query: 516  DGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRS-- 573
              P G+ P P     P  P+ PT G +  A A P   +P  S  P      +   P +  
Sbjct: 742  QAPTGVTPAPS-SAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHI 800

Query: 574  -------PERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASV 626
                   P+R  SP          P  P  G AG P++P  AQPP       L   G   
Sbjct: 801  QQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPP-------LHGQGPPG 853

Query: 627  SSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPP--SKPRSPNPAA 684
              SL              ++GP +            HP  P PF  PP  S+ ++P   +
Sbjct: 854  PHSL--------------QAGPLL-----------QHPGPPQPFGLPPQASQGQAPLGTS 888

Query: 685  PALAAPAV-VPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPP 743
            PA A P   +  P S +    Q PP  Q    PL  +P+      PPP+ P    P P  
Sbjct: 889  PAAAYPHTSLQLPASQSALQSQQPPREQ----PLPPAPLAMPHIKPPPTTPIPQLPAPQA 944

Query: 744  TKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFP---PPEEAFFSVASP 800
             K P  +      S  A       N PPPP   P    LS    P   PP       + P
Sbjct: 945  HKHPPHLSGPSPFSMNA-------NLPPPPALKPLSS-LSTHHPPSAHPPPLQLMPQSQP 996

Query: 801  EPAGPSGSPELVSS-----PAASSSSATALQIQP----------PGSPDP--PPAPPAPA 843
             P+ P+  P L  S     P AS       Q+ P          PG P P  PP  P+ +
Sbjct: 997  LPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTS 1056

Query: 844  PASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPAL 903
               + PG  A+ P     G +  GG        PL T  + +   L     P   P P  
Sbjct: 1057 TPPAGPGTSAQPPCS---GAAASGGSIAGGSSCPLPTVQIKEEA-LDDAEEPESPPPPPR 1112

Query: 904  GPSAP----QKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAE 959
             PS        P   + S R            A   L    LA S+ L+  +     +A+
Sbjct: 1113 SPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSK-LAKKREEAIEKAK 1171

Query: 960  PRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSP 1019
                Q           K   + + E+    E + + +R   AE  + +     +     P
Sbjct: 1172 REAEQ-----------KAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDP 1220

Query: 1020 KAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGL--------PHTQDRTKR 1064
            +   P   +PS   PP    + P   P   P T  L        PH    T R
Sbjct: 1221 QLSGPGHMRPSFEPPPTTIAAVP---PYIGPDTPALRTLSEYARPHVMSPTNR 1270



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 105/433 (24%), Positives = 148/433 (34%), Gaps = 66/433 (15%)

Query: 660  IPP--HPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDAS-PQSPPTPQTTLTP 716
            +PP   P  P PF   P K      +           G +ST  +   + P +P    +P
Sbjct: 542  LPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSP 601

Query: 717  LQESPVISKDQSPPPSPPPSYHPPPPPTKKP--EVVVEAPS------------ASETAE- 761
            + E    S   SP  +   S        KK   +V  EA S            AS+T E 
Sbjct: 602  INEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEA 661

Query: 762  ----------EPLQDPNWPPPPP-PAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPE 810
                      + +  PN P      + + + ++      P++      S  P+ PS  P+
Sbjct: 662  DRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPS--PQ 719

Query: 811  LVSSPAASSSSATALQIQPPGSPDPPPAPPAPA------PASSAPGHVAKLPQKEPVGCS 864
               S + SS+    LQ QPP    P    PAP+      P    PG         P G  
Sbjct: 720  DNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSP 779

Query: 865  KGGGPPREDVG--APLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASP 922
                 P +     AP+    + Q   L     P   P P   P  P +PL    +G A  
Sbjct: 780  TASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPL----TGSAGQ 835

Query: 923  VPAPSSGLHAAVRLKACSLAASEGLSSA---QPNGPPEAEPRPPQSPASTASFIFSKGSR 979
              APS   HA   L          L +    Q  GPP+    PPQ+         S+G  
Sbjct: 836  PSAPS---HAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQA---------SQGQA 883

Query: 980  KLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPAS- 1038
             L    P +      LQ  L A   ++  Q+PP   ++ P  P P+A  P +  PP    
Sbjct: 884  PLGTS-PAAAYPHTSLQ--LPASQSALQSQQPP---REQPLPPAPLA-MPHIKPPPTTPI 936

Query: 1039 PSYPRAEPLTAPP 1051
            P  P  +    PP
Sbjct: 937  PQLPAPQAHKHPP 949



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 43/172 (25%), Positives = 66/172 (38%), Gaps = 26/172 (15%)

Query: 927  SSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERP 986
            SS     ++ +  +L A  G++ A  + PP     P   P  +A+ +  +GS     + P
Sbjct: 727  SSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTAS-QAP 785

Query: 987  VSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEP 1046
              P+          A    +      QAP   P+ PP          PPP    +P  +P
Sbjct: 786  NQPQ----------APTAPVPHTHIQQAPALHPQRPPSPH-------PPPHPSPHPPLQP 828

Query: 1047 LT------APPTNGLP--HTQDRTKRELAENGGVLQLVGPEEKMGLPGSDSQ 1090
            LT      + P++  P  H Q        + G +LQ  GP +  GLP   SQ
Sbjct: 829  LTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQ 880


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  110 bits (274), Expect = 9e-24
 Identities = 173/713 (24%), Positives = 241/713 (33%), Gaps = 146/713 (20%)

Query: 370  GRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDG 429
            GR ++   + C +H      +  + +   V  P    +      D  S   S  T  S G
Sbjct: 522  GRENILLCTDCRIHFKKYGELPPIEK--PVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRG 579

Query: 430  STLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSV 489
            S  + + G + QP S     S +      SGR SPS  ST          SS      +V
Sbjct: 580  SMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAAST----------SSNDSKAETV 629

Query: 490  --SLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGA 547
              S +K+K     P +++   QR     D         ++ +  ++ RP           
Sbjct: 630  KKSAKKVKEEASSPLKSNK-RQREKVASDTEEADRTSSKKTKTQEISRPN---------- 678

Query: 548  APCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGK 607
                                           SPS G    S + ++  +G + P      
Sbjct: 679  -------------------------------SPSEGEGESSDSRSVNDEGSSDPK----- 702

Query: 608  AQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVP 667
                       +     S S S+ S   + SD   SD S  Q +       +  P    P
Sbjct: 703  ----------DIDQDNRSTSPSIPSPQDNESD---SDSSAQQQMLQAQPPALQAPTGVTP 749

Query: 668  APFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSP--PTPQTTLTPLQESPVISK 725
            AP S PP  P+ P P  P  +A AV P    T   +P  P  PT     T +Q++P +  
Sbjct: 750  APSSAPPGTPQLPTPG-PTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHP 808

Query: 726  DQSPPPSPPPSYHPPPPPTKKPEV-VVEAPSASETAEEPLQDPNWPPPPPPAPEE-QDLS 783
             + P P PPP  HP P P  +P       PSA   A+ PL         PP P   Q   
Sbjct: 809  QRPPSPHPPP--HPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQG-----PPGPHSLQAGP 861

Query: 784  MADFPPPEEAFFSVASPEPAGPSGSPELVSSPAAS--------SSSATALQIQPPGSPDP 835
            +   P P + F       P    G   L +SPAA+         +S +ALQ Q P    P
Sbjct: 862  LLQHPGPPQPF----GLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQP 917

Query: 836  -PPAPPA-----PAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRL 889
             PPAP A     P P +  P   A    K P   S   GP    + A L  P  L+ +  
Sbjct: 918  LPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLS---GPSPFSMNANLPPPPALKPLSS 974

Query: 890  RSVGAPGGAPTPALG--------PSAPQKPLRRALSGRASPVPA--PSSGLHAAVRLKAC 939
             S   P  A  P L         PS+P +P     S    P PA  P +GLH        
Sbjct: 975  LSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPF 1034

Query: 940  SLAASEGLSSAQPNGPPEAEP-------RPPQSPASTASFIFSKGSRKLQLERPVSPETQ 992
            +           P GPP   P        PP  P ++A    S  +            + 
Sbjct: 1035 AQ------HPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAA-----------SG 1077

Query: 993  ADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPS-----VGVPPPASPS 1040
              +       L ++  +       + P++PPP  R PS     V  P  AS S
Sbjct: 1078 GSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQS 1130



 Score =  105 bits (263), Expect = 2e-22
 Identities = 182/773 (23%), Positives = 259/773 (33%), Gaps = 148/773 (19%)

Query: 370  GRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRS-----------RHPSSSSDTWSH 418
            G+ S+RT         S +++RS GR    +SP  R+           R+  S++ T S+
Sbjct: 568  GKHSMRTRRS----RGSMSTLRS-GRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSN 622

Query: 419  SQSSDTIVSDGSTLSSKGGSE------------GQPESSTASNSVVPPPQGGSGRGSPSG 466
               ++T+      +  +  S                E +  ++S     Q  S   SPS 
Sbjct: 623  DSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSE 682

Query: 467  GSTAEASDTLSIRSSGQLSGRSVSLRKLKRPP--PPPRRTHS---------LHQRGLAVP 515
            G   E+SD+ S+   G    + +        P  P P+   S         + Q      
Sbjct: 683  GE-GESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPAL 741

Query: 516  DGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRS-- 573
              P G+ P P     P  P+ PT G +  A A P   +P  S  P      +   P +  
Sbjct: 742  QAPTGVTPAPS-SAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHI 800

Query: 574  -------PERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASV 626
                   P+R  SP          P  P  G AG P++P  AQPP       L   G   
Sbjct: 801  QQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPP-------LHGQGPPG 853

Query: 627  SSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPP--SKPRSPNPAA 684
              SL              ++GP +            HP  P PF  PP  S+ ++P   +
Sbjct: 854  PHSL--------------QAGPLL-----------QHPGPPQPFGLPPQASQGQAPLGTS 888

Query: 685  PALAAPAV-VPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPP 743
            PA A P   +  P S +    Q PP  Q    PL  +P+      PPP+ P    P P  
Sbjct: 889  PAAAYPHTSLQLPASQSALQSQQPPREQ----PLPPAPLAMPHIKPPPTTPIPQLPAPQA 944

Query: 744  TKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFP---PPEEAFFSVASP 800
             K P  +      S  A       N PPPP   P    LS    P   PP       + P
Sbjct: 945  HKHPPHLSGPSPFSMNA-------NLPPPPALKPLSS-LSTHHPPSAHPPPLQLMPQSQP 996

Query: 801  EPAGPSGSPELVSS-----PAASSSSATALQIQP----------PGSPDP--PPAPPAPA 843
             P+ P+  P L  S     P AS       Q+ P          PG P P  PP  P+ +
Sbjct: 997  LPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTS 1056

Query: 844  PASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPAL 903
               + PG  A+ P     G +  GG        PL T  + +   L     P   P P  
Sbjct: 1057 TPPAGPGTSAQPPCS---GAAASGGSIAGGSSCPLPTVQIKEEA-LDDAEEPESPPPPPR 1112

Query: 904  GPSAP----QKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAE 959
             PS        P   + S R            A   L    LA S+ L+  +     +A+
Sbjct: 1113 SPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSK-LAKKREEAIEKAK 1171

Query: 960  PRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSP 1019
                Q           K   + + E+    E + + +R   AE  + +     +     P
Sbjct: 1172 REAEQ-----------KAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDP 1220

Query: 1020 KAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGL--------PHTQDRTKR 1064
            +   P   +PS   PP    + P   P   P T  L        PH    T R
Sbjct: 1221 QLSGPGHMRPSFEPPPTTIAAVP---PYIGPDTPALRTLSEYARPHVMSPTNR 1270



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 105/433 (24%), Positives = 148/433 (34%), Gaps = 66/433 (15%)

Query: 660  IPP--HPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDAS-PQSPPTPQTTLTP 716
            +PP   P  P PF   P K      +           G +ST  +   + P +P    +P
Sbjct: 542  LPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSP 601

Query: 717  LQESPVISKDQSPPPSPPPSYHPPPPPTKKP--EVVVEAPS------------ASETAE- 761
            + E    S   SP  +   S        KK   +V  EA S            AS+T E 
Sbjct: 602  INEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEA 661

Query: 762  ----------EPLQDPNWPPPPP-PAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPE 810
                      + +  PN P      + + + ++      P++      S  P+ PS  P+
Sbjct: 662  DRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPS--PQ 719

Query: 811  LVSSPAASSSSATALQIQPPGSPDPPPAPPAPA------PASSAPGHVAKLPQKEPVGCS 864
               S + SS+    LQ QPP    P    PAP+      P    PG         P G  
Sbjct: 720  DNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSP 779

Query: 865  KGGGPPREDVG--APLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASP 922
                 P +     AP+    + Q   L     P   P P   P  P +PL    +G A  
Sbjct: 780  TASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPL----TGSAGQ 835

Query: 923  VPAPSSGLHAAVRLKACSLAASEGLSSA---QPNGPPEAEPRPPQSPASTASFIFSKGSR 979
              APS   HA   L          L +    Q  GPP+    PPQ+         S+G  
Sbjct: 836  PSAPS---HAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQA---------SQGQA 883

Query: 980  KLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPAS- 1038
             L    P +      LQ  L A   ++  Q+PP   ++ P  P P+A  P +  PP    
Sbjct: 884  PLGTS-PAAAYPHTSLQ--LPASQSALQSQQPP---REQPLPPAPLA-MPHIKPPPTTPI 936

Query: 1039 PSYPRAEPLTAPP 1051
            P  P  +    PP
Sbjct: 937  PQLPAPQAHKHPP 949



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 43/172 (25%), Positives = 66/172 (38%), Gaps = 26/172 (15%)

Query: 927  SSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERP 986
            SS     ++ +  +L A  G++ A  + PP     P   P  +A+ +  +GS     + P
Sbjct: 727  SSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTAS-QAP 785

Query: 987  VSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEP 1046
              P+          A    +      QAP   P+ PP          PPP    +P  +P
Sbjct: 786  NQPQ----------APTAPVPHTHIQQAPALHPQRPPSPH-------PPPHPSPHPPLQP 828

Query: 1047 LT------APPTNGLP--HTQDRTKRELAENGGVLQLVGPEEKMGLPGSDSQ 1090
            LT      + P++  P  H Q        + G +LQ  GP +  GLP   SQ
Sbjct: 829  LTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQ 880


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score =  109 bits (273), Expect = 1e-23
 Identities = 153/683 (22%), Positives = 240/683 (35%), Gaps = 79/683 (11%)

Query: 412  SSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASN---------SVVPPPQGGSGRG 462
            SS + S S SS TI    S+ +S    E Q +     N         +  PP    +G G
Sbjct: 125  SSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSG 184

Query: 463  SPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPP-PRRTHSLHQRGLAVPDGPLGL 521
              +G       DT + + +   +   ++  K   P P  P  + +  +  L V       
Sbjct: 185  LDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTV-----NK 239

Query: 522  PPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGS--RRPPRSPERTLS 579
                E K+     +  +T G E   +A    +   +    L+P      +P    E T  
Sbjct: 240  ETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTK 299

Query: 580  PSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSD 639
              +  + +  TPT P +     PAS    +P      ++  +P     ++  S  ++  +
Sbjct: 300  GPALTTPKEPTPTTPKE-----PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKE 354

Query: 640  PAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPP--PSKPRSPNPAAPALAAPAVVPGPV 697
            PAP+    P   TP   +   P   K PAP +    P+ P+ P P  P   AP     P 
Sbjct: 355  PAPTTTKEPAPTTP---KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 411

Query: 698  STTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSAS 757
             TT   P +P TP+    P  + P  +  + P P+ P    P P   K+P        A 
Sbjct: 412  PTTPKEP-TPTTPKEP-APTTKEPAPTTPKEPAPTAPKK--PAPTTPKEPAPTTPKEPAP 467

Query: 758  ETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAA 817
             T +EP   P  P  P P   +   +    P P     +  +P+   P+ + E   +P  
Sbjct: 468  TTTKEP--SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE--PAPTT 523

Query: 818  SSSSATALQIQPPGSPDPPPAPPAPA-PASSAPGHVAKLPQKEPVGCSKGGGPPREDVGA 876
                A     +P  +    PAP  P  PA +     A    KEP   +     P      
Sbjct: 524  PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTP--- 580

Query: 877  PLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRL 936
              +TP+  + +   +   P       L P+ P++P     +      PAP++        
Sbjct: 581  KKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP-----TPTTPEEPAPTTP------- 628

Query: 937  KACSLAASEGLSSAQPNGPPEAEPRPPQSPASTA----SFIFSKGSRKLQLERPV--SPE 990
                 AA        P  P E  P  P+ PA T     +    KG+    L+ P   +P+
Sbjct: 629  ---KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPK 685

Query: 991  TQA--DLQRNLVAELRSISEQRP---------PQAPKK----SPKAPPPVARKPSVGV-- 1033
              A  +L      E  S +  +P         P  PK+    +PK P P   K +     
Sbjct: 686  KPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTL 745

Query: 1034 --PPPASPSYPRAEPLTAPPTNG 1054
              P P +P  P  + L    T G
Sbjct: 746  KEPAPTTPKKPAPKELAPTTTKG 768



 Score =  102 bits (253), Expect = 3e-21
 Identities = 153/726 (21%), Positives = 239/726 (32%), Gaps = 82/726 (11%)

Query: 403  QPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRG 462
            +P S  P   + T   S  +       +T  S   +  +P  +T        P+  +   
Sbjct: 316  EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 375

Query: 463  SPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPP--PPRRTHSLHQRGLAVPDGPLG 520
            +     T   S   + +     + +  +    K P P  P   T +  +        P  
Sbjct: 376  TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP 435

Query: 521  LPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSP 580
              PK      P+ P P T    E A   P  P P  +  P      S   P+ P  T + 
Sbjct: 436  TTPKEPAPTAPKKPAPTTP--KEPAPTTPKEPAPTTTKEP------SPTTPKEPAPTTTK 487

Query: 581  SSGYSSQSGTPTLPPKGLAGPPA-SPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSD 639
            S+  +++   PT        P   SP   + P P   T+ + P  +         ++  +
Sbjct: 488  SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP---TTPKEPAPTTPKKPAP--TTPKE 542

Query: 640  PAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPN---PAAPALAAPAVVPGP 696
            PAP+    P    P   +   P  PK PAP +P  + P +P    P  P   AP     P
Sbjct: 543  PAPTTPKEP---APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP 599

Query: 697  VSTT--DASPQSP--PTPQTT-----LTPLQESPVISKDQSP--PPSPPPSYHPPPPPTK 745
              TT  + +P +P  PTP T       TP   +P   K+ +P  P  P P+    P PT 
Sbjct: 600  APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT 659

Query: 746  KPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFP----------------- 788
              E     P    TA   L++P    P  PAP+E   +    P                 
Sbjct: 660  PKETAPTTPKG--TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 717

Query: 789  ---PPEEAFFSVASPEPAGPSGS-PELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAP 844
               P E A  +   P P  P G+ P  +  PA ++    A +   P +   P +  +  P
Sbjct: 718  PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 777

Query: 845  ASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALG 904
            A + P   A    KEP   +     P      P  T  +      +       +P  +  
Sbjct: 778  APTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST- 836

Query: 905  PSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQ 964
            P    +P  +AL         P++   AA + +  +  A +  +       PE     P+
Sbjct: 837  PELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTT-TAKDKTTERDLRTTPETTTAAPK 895

Query: 965  SPASTASFIFSKGSRKLQLERP-VSPETQADLQRNLVAELRSIS---------------- 1007
                TA+        K+      V+  T  D     +  L++ +                
Sbjct: 896  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 955

Query: 1008 ------EQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEP-LTAPPTNGLPHTQD 1060
                  E   P+    + KA  P  +KP+     P S   P+  P +  P T   P    
Sbjct: 956  IMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMT 1015

Query: 1061 RTKREL 1066
             T  EL
Sbjct: 1016 STMPEL 1021



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 108/479 (22%), Positives = 171/479 (35%), Gaps = 59/479 (12%)

Query: 400 SSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQ--G 457
           ++ +P    P   + T + S  + T     +T  S   +  +P  +T        P+   
Sbjct: 469 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 528

Query: 458 GSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDG 517
            +    P+  +  E + T     +   + +       +  P  P+ T          P  
Sbjct: 529 PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKET---------APTT 579

Query: 518 PLGLPPKPERKQQPQLP-RPPTTGGSEGAGAAPCPPNPANSWVPG------LSPGGSRRP 570
           P  L P    K  P  P +P  T   E A   P  P P     P        +P   + P
Sbjct: 580 PKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEP 639

Query: 571 ----PRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASV 626
               P+ P  T       ++   T    PKG A  P +  +  P  P++         + 
Sbjct: 640 APTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA--PTTLKEPAPTTPKKPAPKELAPTTT 697

Query: 627 SSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRS------- 679
               ++ C     PAP+   G    TP   +   P  PK PAP +P  + P +       
Sbjct: 698 KEPTSTTCDK---PAPTTPKGTAPTTP---KEPAPTTPKEPAPTTPKGTAPTTLKEPAPT 751

Query: 680 -PNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTT--LTPLQESPVISKDQSP--PPSPP 734
            P   AP   AP    GP STT   P +P TP+ T   TP + +P   K  +P  P +PP
Sbjct: 752 TPKKPAPKELAPTTTKGPTSTTSDKP-APTTPKETAPTTPKEPAPTTPKKPAPTTPETPP 810

Query: 735 P--SYHPPPPPTKKPEVVVEAP--SASETAEEPL--------QDPNWPPPPPPAPEEQDL 782
           P  S    P  TK+P  + ++P  S  E + EP         ++P  P    PA  + ++
Sbjct: 811 PTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEM 870

Query: 783 -SMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSS---ATALQIQPPGSPDPPP 837
            + A     E    +      A P  + E  ++   ++ S   AT  Q+    + D  P
Sbjct: 871 TTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 929


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score =  109 bits (273), Expect = 1e-23
 Identities = 153/683 (22%), Positives = 240/683 (35%), Gaps = 79/683 (11%)

Query: 412  SSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASN---------SVVPPPQGGSGRG 462
            SS + S S SS TI    S+ +S    E Q +     N         +  PP    +G G
Sbjct: 166  SSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSG 225

Query: 463  SPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPP-PRRTHSLHQRGLAVPDGPLGL 521
              +G       DT + + +   +   ++  K   P P  P  + +  +  L V       
Sbjct: 226  LDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTV-----NK 280

Query: 522  PPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGS--RRPPRSPERTLS 579
                E K+     +  +T G E   +A    +   +    L+P      +P    E T  
Sbjct: 281  ETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTK 340

Query: 580  PSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSD 639
              +  + +  TPT P +     PAS    +P      ++  +P     ++  S  ++  +
Sbjct: 341  GPALTTPKEPTPTTPKE-----PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKE 395

Query: 640  PAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPP--PSKPRSPNPAAPALAAPAVVPGPV 697
            PAP+    P   TP   +   P   K PAP +    P+ P+ P P  P   AP     P 
Sbjct: 396  PAPTTTKEPAPTTP---KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 452

Query: 698  STTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSAS 757
             TT   P +P TP+    P  + P  +  + P P+ P    P P   K+P        A 
Sbjct: 453  PTTPKEP-TPTTPKEP-APTTKEPAPTTPKEPAPTAPKK--PAPTTPKEPAPTTPKEPAP 508

Query: 758  ETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAA 817
             T +EP   P  P  P P   +   +    P P     +  +P+   P+ + E   +P  
Sbjct: 509  TTTKEP--SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE--PAPTT 564

Query: 818  SSSSATALQIQPPGSPDPPPAPPAPA-PASSAPGHVAKLPQKEPVGCSKGGGPPREDVGA 876
                A     +P  +    PAP  P  PA +     A    KEP   +     P      
Sbjct: 565  PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTP--- 621

Query: 877  PLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRL 936
              +TP+  + +   +   P       L P+ P++P     +      PAP++        
Sbjct: 622  KKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP-----TPTTPEEPAPTTP------- 669

Query: 937  KACSLAASEGLSSAQPNGPPEAEPRPPQSPASTA----SFIFSKGSRKLQLERPV--SPE 990
                 AA        P  P E  P  P+ PA T     +    KG+    L+ P   +P+
Sbjct: 670  ---KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPK 726

Query: 991  TQA--DLQRNLVAELRSISEQRP---------PQAPKK----SPKAPPPVARKPSVGV-- 1033
              A  +L      E  S +  +P         P  PK+    +PK P P   K +     
Sbjct: 727  KPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTL 786

Query: 1034 --PPPASPSYPRAEPLTAPPTNG 1054
              P P +P  P  + L    T G
Sbjct: 787  KEPAPTTPKKPAPKELAPTTTKG 809



 Score =  102 bits (253), Expect = 3e-21
 Identities = 153/726 (21%), Positives = 239/726 (32%), Gaps = 82/726 (11%)

Query: 403  QPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRG 462
            +P S  P   + T   S  +       +T  S   +  +P  +T        P+  +   
Sbjct: 357  EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 416

Query: 463  SPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPP--PPRRTHSLHQRGLAVPDGPLG 520
            +     T   S   + +     + +  +    K P P  P   T +  +        P  
Sbjct: 417  TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP 476

Query: 521  LPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSP 580
              PK      P+ P P T    E A   P  P P  +  P      S   P+ P  T + 
Sbjct: 477  TTPKEPAPTAPKKPAPTTP--KEPAPTTPKEPAPTTTKEP------SPTTPKEPAPTTTK 528

Query: 581  SSGYSSQSGTPTLPPKGLAGPPA-SPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSD 639
            S+  +++   PT        P   SP   + P P   T+ + P  +         ++  +
Sbjct: 529  SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP---TTPKEPAPTTPKKPAP--TTPKE 583

Query: 640  PAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPN---PAAPALAAPAVVPGP 696
            PAP+    P    P   +   P  PK PAP +P  + P +P    P  P   AP     P
Sbjct: 584  PAPTTPKEP---APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP 640

Query: 697  VSTT--DASPQSP--PTPQTT-----LTPLQESPVISKDQSP--PPSPPPSYHPPPPPTK 745
              TT  + +P +P  PTP T       TP   +P   K+ +P  P  P P+    P PT 
Sbjct: 641  APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT 700

Query: 746  KPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFP----------------- 788
              E     P    TA   L++P    P  PAP+E   +    P                 
Sbjct: 701  PKETAPTTPKG--TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 758

Query: 789  ---PPEEAFFSVASPEPAGPSGS-PELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAP 844
               P E A  +   P P  P G+ P  +  PA ++    A +   P +   P +  +  P
Sbjct: 759  PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 818

Query: 845  ASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALG 904
            A + P   A    KEP   +     P      P  T  +      +       +P  +  
Sbjct: 819  APTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST- 877

Query: 905  PSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQ 964
            P    +P  +AL         P++   AA + +  +  A +  +       PE     P+
Sbjct: 878  PELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTT-TAKDKTTERDLRTTPETTTAAPK 936

Query: 965  SPASTASFIFSKGSRKLQLERP-VSPETQADLQRNLVAELRSIS---------------- 1007
                TA+        K+      V+  T  D     +  L++ +                
Sbjct: 937  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 996

Query: 1008 ------EQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEP-LTAPPTNGLPHTQD 1060
                  E   P+    + KA  P  +KP+     P S   P+  P +  P T   P    
Sbjct: 997  IMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMT 1056

Query: 1061 RTKREL 1066
             T  EL
Sbjct: 1057 STMPEL 1062



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 108/479 (22%), Positives = 171/479 (35%), Gaps = 59/479 (12%)

Query: 400 SSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQ--G 457
           ++ +P    P   + T + S  + T     +T  S   +  +P  +T        P+   
Sbjct: 510 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 569

Query: 458 GSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDG 517
            +    P+  +  E + T     +   + +       +  P  P+ T          P  
Sbjct: 570 PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKET---------APTT 620

Query: 518 PLGLPPKPERKQQPQLP-RPPTTGGSEGAGAAPCPPNPANSWVPG------LSPGGSRRP 570
           P  L P    K  P  P +P  T   E A   P  P P     P        +P   + P
Sbjct: 621 PKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEP 680

Query: 571 ----PRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASV 626
               P+ P  T       ++   T    PKG A  P +  +  P  P++         + 
Sbjct: 681 APTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA--PTTLKEPAPTTPKKPAPKELAPTTT 738

Query: 627 SSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRS------- 679
               ++ C     PAP+   G    TP   +   P  PK PAP +P  + P +       
Sbjct: 739 KEPTSTTCDK---PAPTTPKGTAPTTP---KEPAPTTPKEPAPTTPKGTAPTTLKEPAPT 792

Query: 680 -PNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTT--LTPLQESPVISKDQSP--PPSPP 734
            P   AP   AP    GP STT   P +P TP+ T   TP + +P   K  +P  P +PP
Sbjct: 793 TPKKPAPKELAPTTTKGPTSTTSDKP-APTTPKETAPTTPKEPAPTTPKKPAPTTPETPP 851

Query: 735 P--SYHPPPPPTKKPEVVVEAP--SASETAEEPL--------QDPNWPPPPPPAPEEQDL 782
           P  S    P  TK+P  + ++P  S  E + EP         ++P  P    PA  + ++
Sbjct: 852 PTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEM 911

Query: 783 -SMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSS---ATALQIQPPGSPDPPP 837
            + A     E    +      A P  + E  ++   ++ S   AT  Q+    + D  P
Sbjct: 912 TTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 970


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score =  108 bits (271), Expect = 2e-23
 Identities = 167/669 (24%), Positives = 227/669 (33%), Gaps = 144/669 (21%)

Query: 414  DTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEAS 473
            D  S   S  T  S GS  + + G + QP S     S +      SGR SPS  ST    
Sbjct: 10   DGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAAST---- 65

Query: 474  DTLSIRSSGQLSGRSV--SLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQP 531
                  SS      +V  S +K+K     P +++   QR     D         ++ +  
Sbjct: 66   ------SSNDSKAETVKKSAKKVKEEASSPLKSNK-RQREKVASDTEEADRTSSKKTKTQ 118

Query: 532  QLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTP 591
            ++ RP                                          SPS G    S + 
Sbjct: 119  EISRPN-----------------------------------------SPSEGEGESSDSR 137

Query: 592  TLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQIL 651
            ++  +G + P                 +     S S S+ S   + SD   SD S  Q +
Sbjct: 138  SVNDEGSSDPK---------------DIDQDNRSTSPSIPSPQDNESD---SDSSAQQQM 179

Query: 652  TPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSP--PT 709
                   +  P    PAP S PP  P+ P P  P  +A AV P    T   +P  P  PT
Sbjct: 180  LQAQPPALQAPTGVTPAPSSAPPGTPQLPTPG-PTPSATAVPPQGSPTASQAPNQPQAPT 238

Query: 710  PQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEV-VVEAPSASETAEEPLQDPN 768
                 T +Q++P +   + P P PPP  HP P P  +P       PSA   A+ PL    
Sbjct: 239  APVPHTHIQQAPALHPQRPPSPHPPP--HPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQG 296

Query: 769  WPPPPPPAPEE-QDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAAS--------S 819
                 PP P   Q   +   P P + F       P    G   L +SPAA+         
Sbjct: 297  -----PPGPHSLQAGPLLQHPGPPQPF----GLPPQASQGQAPLGTSPAAAYPHTSLQLP 347

Query: 820  SSATALQIQPPGSPDP-PPAPPA-----PAPASSAPGHVAKLPQKEPVGCSKGGGPPRED 873
            +S +ALQ Q P    P PPAP A     P P +  P   A    K P   S   GP    
Sbjct: 348  ASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLS---GPSPFS 404

Query: 874  VGAPLVTPSLLQMVRLRSVGAPGGAPTPALG--------PSAPQKPLRRALSGRASPVPA 925
            + A L  P  L+ +   S   P  A  P L         PS+P +P     S    P PA
Sbjct: 405  MNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPA 464

Query: 926  --PSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEP-------RPPQSPASTASFIFSK 976
              P +GLH        +           P GPP   P        PP  P ++A    S 
Sbjct: 465  SHPPTGLHQVAPQPPFAQ------HPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSG 518

Query: 977  GSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPS-----V 1031
             +            +   +       L ++  +       + P++PPP  R PS     V
Sbjct: 519  AAA-----------SGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVV 567

Query: 1032 GVPPPASPS 1040
              P  AS S
Sbjct: 568  DTPSHASQS 576



 Score =  105 bits (263), Expect = 2e-22
 Identities = 182/773 (23%), Positives = 259/773 (33%), Gaps = 148/773 (19%)

Query: 370  GRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRS-----------RHPSSSSDTWSH 418
            G+ S+RT         S +++RS GR    +SP  R+           R+  S++ T S+
Sbjct: 14   GKHSMRTRRS----RGSMSTLRS-GRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSN 68

Query: 419  SQSSDTIVSDGSTLSSKGGSE------------GQPESSTASNSVVPPPQGGSGRGSPSG 466
               ++T+      +  +  S                E +  ++S     Q  S   SPS 
Sbjct: 69   DSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSE 128

Query: 467  GSTAEASDTLSIRSSGQLSGRSVSLRKLKRPP--PPPRRTHS---------LHQRGLAVP 515
            G   E+SD+ S+   G    + +        P  P P+   S         + Q      
Sbjct: 129  GE-GESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPAL 187

Query: 516  DGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRS-- 573
              P G+ P P     P  P+ PT G +  A A P   +P  S  P      +   P +  
Sbjct: 188  QAPTGVTPAPS-SAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHI 246

Query: 574  -------PERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASV 626
                   P+R  SP          P  P  G AG P++P  AQPP       L   G   
Sbjct: 247  QQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPP-------LHGQGPPG 299

Query: 627  SSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPP--SKPRSPNPAA 684
              SL              ++GP +            HP  P PF  PP  S+ ++P   +
Sbjct: 300  PHSL--------------QAGPLL-----------QHPGPPQPFGLPPQASQGQAPLGTS 334

Query: 685  PALAAPAV-VPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPP 743
            PA A P   +  P S +    Q PP  Q    PL  +P+      PPP+ P    P P  
Sbjct: 335  PAAAYPHTSLQLPASQSALQSQQPPREQ----PLPPAPLAMPHIKPPPTTPIPQLPAPQA 390

Query: 744  TKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFP---PPEEAFFSVASP 800
             K P  +      S  A       N PPPP   P    LS    P   PP       + P
Sbjct: 391  HKHPPHLSGPSPFSMNA-------NLPPPPALKPLSS-LSTHHPPSAHPPPLQLMPQSQP 442

Query: 801  EPAGPSGSPELVSS-----PAASSSSATALQIQP----------PGSPDP--PPAPPAPA 843
             P+ P+  P L  S     P AS       Q+ P          PG P P  PP  P+ +
Sbjct: 443  LPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTS 502

Query: 844  PASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPAL 903
               + PG  A+ P     G +  GG        PL T  + +   L     P   P P  
Sbjct: 503  TPPAGPGTSAQPPCS---GAAASGGSIAGGSSCPLPTVQIKEEA-LDDAEEPESPPPPPR 558

Query: 904  GPSAP----QKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAE 959
             PS        P   + S R            A   L    LA S+ L+  +     +A+
Sbjct: 559  SPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSK-LAKKREEAIEKAK 617

Query: 960  PRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSP 1019
                Q           K   + + E+    E + + +R   AE  + +     +     P
Sbjct: 618  REAEQ-----------KAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDP 666

Query: 1020 KAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGL--------PHTQDRTKR 1064
            +   P   +PS   PP    + P   P   P T  L        PH    T R
Sbjct: 667  QLSGPGHMRPSFEPPPTTIAAVP---PYIGPDTPALRTLSEYARPHVMSPTNR 716



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 43/172 (25%), Positives = 66/172 (38%), Gaps = 26/172 (15%)

Query: 927  SSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERP 986
            SS     ++ +  +L A  G++ A  + PP     P   P  +A+ +  +GS     + P
Sbjct: 173  SSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTAS-QAP 231

Query: 987  VSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEP 1046
              P+          A    +      QAP   P+ PP          PPP    +P  +P
Sbjct: 232  NQPQ----------APTAPVPHTHIQQAPALHPQRPPSPH-------PPPHPSPHPPLQP 274

Query: 1047 LT------APPTNGLP--HTQDRTKRELAENGGVLQLVGPEEKMGLPGSDSQ 1090
            LT      + P++  P  H Q        + G +LQ  GP +  GLP   SQ
Sbjct: 275  LTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQ 326


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score =  108 bits (270), Expect = 3e-23
 Identities = 177/783 (22%), Positives = 269/783 (34%), Gaps = 156/783 (19%)

Query: 334  PAEPLSPAMSISPQA-TYLSKLIPHAVLPPTVDVV-ALGRCSLRTLSRCSLHSASPASVR 391
            P  P  P +S S    T+ S+       P T+ +  +  R  L+   + S+     + V 
Sbjct: 102  PGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVN 161

Query: 392  SLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSV 451
            +L   SSV +         +  D  S S++S    +    +  K   +G+PE        
Sbjct: 162  ALSAVSSVVNK-------FNPFDLISDSEASQEETTKKQKVVQK--EQGKPEGIIKPPLQ 212

Query: 452  VPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRG 511
              PP+    +  P      +     SI S            K+K  PP           G
Sbjct: 213  QQPPKPIPKQQGPGRDPLQQDGTPKSISSQQP--------EKIKSQPP-----------G 253

Query: 512  LAVP-DGPLGLPPKPERKQ--QPQLPRPPTTGGS--EGAGAAPCPPNPANSWVPGLSPG- 565
               P  GP   P     K   Q    RP T       G    P  P+P+   +   +PG 
Sbjct: 254  TGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGK 313

Query: 566  -------------GSRRPPRSPERTLSPSSGYSSQSGT--PTLPPKGLAGPPASP-GKAQ 609
                         G  +PP  P     P    + Q GT  P + P G   PPA P G A+
Sbjct: 314  PPAQQPGHEKSQPGPAKPPAQPSGLTKP---LAQQPGTVKPPVQPPGTTKPPAQPLGPAK 370

Query: 610  PPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILT-PLGDRFVIPPHPKVPA 668
            PP  +                     + S+   S++ GP+ L  P G   V     + P 
Sbjct: 371  PPAQQ---------------------TGSEKPSSEQPGPKALAQPPG---VGKTPAQQPG 406

Query: 669  PFSPPPSKPRSPNPAA--PALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKD 726
            P  PP  +  +P P A  P L +PA  PGP  T    P   P P   +   Q  P  +  
Sbjct: 407  PAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKT----PVQQPGP-GKIPAQQAGPGKTSA 461

Query: 727  QSPPPSPPPSYHPPP--PPTKKPEVVVEAPSASETAEEPLQDPNWPPPPP-------PAP 777
            Q   P+ PPS  P P  PP ++P      P    +A+ P Q P    PPP       P+P
Sbjct: 462  QQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSP 521

Query: 778  EEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQ--IQPPGSPDP 835
            ++   +      P  A  S   P PA PS      + P + + S   LQ     P +  P
Sbjct: 522  QQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQS--TKPVSQTGSGKPLQPPTVSPSAKQP 579

Query: 836  PP--APPAPAPASSAPGHVAKLPQK---------EPVGCSKGGGPPREDVGAPLVTPSLL 884
            P    P    P  +    +  +P+K         +   CS  G  P          P L 
Sbjct: 580  PSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNP---------NPHLT 630

Query: 885  QMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAAS 944
            ++     +                   ++RAL G  +PVP+         +LK   +  +
Sbjct: 631  EVKEWLCLNC----------------QMKRALGGDLAPVPSSPQ-----PKLKTAPVTTT 669

Query: 945  EGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADL-QRNLVAEL 1003
              +S + P  P +  P+   +P             K  L +   P+    L ++  +   
Sbjct: 670  SAVSKSSPQ-PQQTSPKKDAAP-------------KQDLSKAPEPKKPPPLVKQPTLHGS 715

Query: 1004 RSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTK 1063
             S   ++PP+A   S  APP     PS     P +   P+   +  P T+ +  +   TK
Sbjct: 716  PSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTK 775

Query: 1064 REL 1066
             ++
Sbjct: 776  PDI 778



 Score =  106 bits (264), Expect = 1e-22
 Identities = 171/679 (25%), Positives = 235/679 (34%), Gaps = 134/679 (19%)

Query: 429  GSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPS-----GGSTAEASDTLSIRSSGQ 483
            G+  S +G  EG PE   A+ +      G SG GSPS      G  A+ S  LS     Q
Sbjct: 2    GNEASLEG--EGLPEGLAAAAAA---GGGASGAGSPSHTAIPAGMEADLSQ-LSEEERRQ 55

Query: 484  LSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSE 543
            ++      + L +   PP    S                P   RKQ+     PP   G  
Sbjct: 56   IAAVMSRAQGLPKGSVPPAAAES----------------PSMHRKQELDSSHPPKQSGR- 98

Query: 544  GAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPA 603
                   PP+P     PGLS   +    RS ++                LP +  +    
Sbjct: 99   -------PPDPGRPAQPGLSKSRTTDTFRSEQK----------------LPGRSPSTISL 135

Query: 604  SPGKAQPPKPERVTSLRSPG-ASVSSSLTSLCSSSSDPAP----SDRSGPQILTPLGDRF 658
               K++    E   S   PG  S  ++L+++ S  +   P    SD    Q  T    + 
Sbjct: 136  KESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKV 195

Query: 659  VIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQ 718
            V     K P     PP + + P P  P    P   P      D +P+S  + Q      Q
Sbjct: 196  VQKEQGK-PEGIIKPPLQQQPPKP-IPKQQGPGRDP---LQQDGTPKSISSQQPEKIKSQ 250

Query: 719  ESPVISKDQSPPPSPPPSYHPPP-------PPTKKPEVVVEAPSASETAEEPLQDPNWPP 771
                    Q P  +P   +   P       P TK+ ++V       E+ +  L  P+ PP
Sbjct: 251  PPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIV-----RGESVKPSLPSPSKPP 305

Query: 772  PPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPG 831
               P P +        PP ++     + P PA P   P  ++ P A         +QPPG
Sbjct: 306  IQQPTPGK--------PPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPG 357

Query: 832  SPDPPPAPPAPA-----------PASSAPG--------HVAKLPQKEPVGCSKGGGPPRE 872
            +  PP  P  PA           P+S  PG         V K P ++P G +K   PP +
Sbjct: 358  TTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQP-GPAK---PPTQ 413

Query: 873  DVGAPLVTPSLLQMVRLRS-VGAPGGAPTPALGPSAPQKPLRRALSGRAS---------- 921
             VG P     L Q   L+S   APG   TP   P   + P ++A  G+ S          
Sbjct: 414  QVGTP---KPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPP 470

Query: 922  ---PVPAPSSGLHAAVRLKACSLAASEGLSSAQPNG--PPEAEPRP----PQSPASTASF 972
               P PA                  S    S QP    PP  +P P    PQ P ST   
Sbjct: 471  SQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPP 530

Query: 973  IFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVG 1032
                GS K   ++P   +  A      V++  S    +P Q P  SP A  P    PS G
Sbjct: 531  SQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGS---GKPLQPPTVSPSAKQP----PSQG 583

Query: 1033 VPPPASPSYPRAEPLTAPP 1051
            +P    P     E L   P
Sbjct: 584  LPKTICPLCNTTELLLHVP 602



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 236/1056 (22%), Positives = 363/1056 (34%), Gaps = 211/1056 (19%)

Query: 112  SGRPPHLEELHTQAQEGLRSLQ----HQEKQKLNKGGWDHGDTQSIQSSRTGPDEDNISF 167
            SGRPP   +    AQ GL   +     + +QKL         T S++ S++  D      
Sbjct: 96   SGRPP---DPGRPAQPGLSKSRTTDTFRSEQKLPGRS---PSTISLKESKSRTDLKEEHK 149

Query: 168  CSQTTSYVAESSTAEDALSIRSEMIQRKGSTFRPHDSFPKSGKSGRRRRERRSTVL---- 223
             S    +++E +    ALS  S ++ +    F P D    S  S     +++  V     
Sbjct: 150  SSMMPGFLSEVN----ALSAVSSVVNK----FNPFDLISDSEASQEETTKKQKVVQKEQG 201

Query: 224  ---GL---------PQHVQKELGL-RNEREAPGTPRAPGARDAVRIPTVDGRPRGTSGMG 270
               G+         P+ + K+ G  R+  +  GTP++  ++   +I +   +P GT G  
Sbjct: 202  KPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKS---QPPGT-GKP 257

Query: 271  ARVSLQALEAEAEAGAETEAMLQRHIDR--VYRDDTFVGRSTGTRAP-PLTRPMSLAVPG 327
             +   Q  + +       +  LQR   R    + D   G S     P P   P+    PG
Sbjct: 258  IQGPTQTPQTD-----HAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPG 312

Query: 328  LTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCSLRTLSRCSLHSASP 387
                  P    S      P A       P A  P TV        + +  ++  L  A P
Sbjct: 313  KPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQ-PLGPAKP 371

Query: 388  ASVRSLGRFSSVSSPQPRS-RHPSSSSDTWSH----SQSSDTIVSDGSTLSSKGGSEGQP 442
             + ++     S   P P++   P     T +     ++     V     L+ + G +   
Sbjct: 372  PAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPA 431

Query: 443  ESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPR 502
            ++   + + V  P  G      +G     A  T   +   QL G +       +PPP   
Sbjct: 432  KAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPA-------KPPP--- 481

Query: 503  RTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGL 562
                  Q G A P        KP   QQP   +PP     +   A P P  P ++  P  
Sbjct: 482  -----QQPGPAKPPPQQPGSAKPP-SQQPGSTKPPP---QQPGPAKPSPQQPGSTKPPSQ 532

Query: 563  SPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPK---PERVTSL 619
             PG ++   + P     PS+  S++  + T   K L  P  SP   QPP    P+ +  L
Sbjct: 533  QPGSAKPSAQQPSPA-KPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPL 591

Query: 620  RSPG---------------ASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHP 664
             +                     +++ SLC  + +P          LT + +   +    
Sbjct: 592  CNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPH---------LTEVKEWLCLNCQM 642

Query: 665  K--VPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPV 722
            K  +    +P PS P+           P +   PV+TT A  +S P PQ T      +P 
Sbjct: 643  KRALGGDLAPVPSSPQ-----------PKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPK 691

Query: 723  ISKDQSPPPSPPP---------------SYHPP-------PPPTKKPEVVVEAPSASETA 760
                ++P P  PP               +  PP       P P K+P V  E   A    
Sbjct: 692  QDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVAD 751

Query: 761  EEPLQDPNWPPPP-----------PPAPEEQDLSMAD-----------------FPPPEE 792
            ++P Q     P             P  P  +  S A+                 FPP  E
Sbjct: 752  DKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGE 811

Query: 793  A---FFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAP 849
                F S A P PA  S   +++S P  SS S    Q+ P    +     P  A    +P
Sbjct: 812  KVSPFDSKAIPRPASDS---KIISHPGPSSESKGQKQVDPVQKKE----EPKKAQTKMSP 864

Query: 850  GHVAKLPQKEPVGCSKGGGP---PREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPS 906
               AK     P G     GP     + V  P  +P   +  R  S+        P   P+
Sbjct: 865  KPDAK---PMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPT 921

Query: 907  APQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEG-LSSAQPNGPPEAEPRPPQS 965
             PQ+ +   L G  + + + +S L         S A   G  S + P  P +  P P Q 
Sbjct: 922  TPQETVTGKLFGFGASIFSQASNL--------ISTAGQPGPHSQSGPGAPMKQAPAPSQP 973

Query: 966  PASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKA--PP 1023
            P        S+G  K   + P +P     +++          E + P A K  PKA   P
Sbjct: 974  PT-------SQGPPKSTGQAPPAPAKSIPVKK----------ETKAPAAEKLEPKAEQAP 1016

Query: 1024 PVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQ 1059
             V R  +   PPP   S    + LTA P   +  T+
Sbjct: 1017 TVKRTETEKKPPPIKDS----KSLTAEPQKAVLPTK 1048



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 92/356 (25%), Positives = 121/356 (33%), Gaps = 46/356 (12%)

Query: 622  PGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPN 681
            P + + S   S+ S  + P P  RS         D    PP P  P P  PPP  P  P 
Sbjct: 2372 PASQLPSGSPSVSSLPAKPRPFFRSSSL------DISAQPPPPPPPPPPPPPPPPPPPPP 2425

Query: 682  PAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPP 741
            P  P  +    +      T ASP +  TP        E+  + +    P +   +  PPP
Sbjct: 2426 PLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPP 2485

Query: 742  PPTKKPEVVVEAPSASETAEEPLQDPNWPP--PPPPAPEEQDLSM--ADFPPPEEAFFSV 797
             P K   +    PS       P  +P+ PP  P P  P+    +    D  P        
Sbjct: 2486 VPPKPSSI----PSGLVFTHRP--EPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLT 2539

Query: 798  AS-------------PEPAGPSGSPELVSSPAASSS-SATALQIQPPGSPDPPPAPPAPA 843
            +S             P P  P       SSP  S S + T + I  P  P  P    A  
Sbjct: 2540 SSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQ 2599

Query: 844  PASSAP-GHVAK-LPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTP 901
              +S P G  +K L   EPV       PP   V  P+ +     +    S      + TP
Sbjct: 2600 AITSWPLGSPSKDLVSVEPVFSVV---PPVTAVEIPISSEQTFYI----SGALQTFSATP 2652

Query: 902  ALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPE 957
               PS+ Q           + V   S    +A R    S A S GLSS     PPE
Sbjct: 2653 VTAPSSFQAAPTSVTQFLTTEV---SKTEVSATR----STAPSVGLSSISITIPPE 2701



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 161/764 (21%), Positives = 236/764 (30%), Gaps = 156/764 (20%)

Query: 381  SLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDT-----IVSDGSTLSSK 435
            +LH +  A  +      S+S P P  + PS  S+      + D      +V   + L S 
Sbjct: 711  TLHGSPSAKAKQPPEADSLSKPAP-PKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSS 769

Query: 436  GGSEGQPE------SSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSV 489
              +  +P+       S A     PP +  S + S S   T E       ++      R  
Sbjct: 770  SSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIP----RPA 825

Query: 490  SLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAP 549
            S  K+   P P     S   +G    D P+    +P++ Q    P+P      +G+   P
Sbjct: 826  SDSKIISHPGP-----SSESKGQKQVD-PVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPP 879

Query: 550  CPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQ 609
             P   A   VP  +P  S +P     R       +S   G+ T  PK           +Q
Sbjct: 880  GPRPTAGQTVP--TPQQSPKPQEQSRR-------FSLNLGSITDAPK-----------SQ 919

Query: 610  PPKPERVTS--LRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPH---- 663
            P  P+   +  L   GAS+ S  ++L S++  P P  +SGP            PP     
Sbjct: 920  PTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGP 979

Query: 664  PKV-----PAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPT--------- 709
            PK      PAP    P K  +  PAA  L   A     V  T+   + PP          
Sbjct: 980  PKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAE 1039

Query: 710  PQTTLTP--LQESPVISKDQSPPP----------SPPPSYH----------------PPP 741
            PQ  + P  L++SP   K +S  P            PP+++                P P
Sbjct: 1040 PQKAVLPTKLEKSP---KPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTP 1096

Query: 742  PPTKKPEVVVEAPSASETAEEPLQDPNWPPPPP--------PAPEEQDLSMADFPPP--- 790
              T+  E +             L D    PP P        P P E        PP    
Sbjct: 1097 HLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKL 1156

Query: 791  -----------EEAFFSVASPEPAGPSGSPELVSSPAASSSS------ATALQIQPPGSP 833
                        E        E       P +V++      S      A+ALQ + P   
Sbjct: 1157 VKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPE 1216

Query: 834  DPPPAP------------------PAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVG 875
            +    P                  P P      P      P+++     K      E+  
Sbjct: 1217 EKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKL 1276

Query: 876  APLVTPSLLQ---MVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHA 932
               V P  +Q     + +  G P G  TP   P    K  +        P  A    +  
Sbjct: 1277 EGRVAPKTVQEGKQPQTKMEGLPSG--TPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEP 1334

Query: 933  AVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASF------------IFSKGSRK 980
                       S+  SS QP  P         S   ++S                KG +K
Sbjct: 1335 GKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKK 1394

Query: 981  LQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPP 1024
                +  SP + +DL +     L  +  Q    A +KS K   P
Sbjct: 1395 DSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQP 1438



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 127/529 (24%), Positives = 182/529 (34%), Gaps = 110/529 (20%)

Query: 595  PKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPL 654
            P+GLA   A+ G A        T++    A + + L+ L         +  S  Q L P 
Sbjct: 13   PEGLAAAAAAGGGASGAGSPSHTAIP---AGMEADLSQLSEEERRQIAAVMSRAQGL-PK 68

Query: 655  GDRFVIPP--------HPKVPAPFSPPPSKP-RSPNPAAPALAAPAVVPGPVSTTDASPQ 705
            G    +PP        H K     S PP +  R P+P  PA   P +     + T  S Q
Sbjct: 69   GS---VPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPA--QPGLSKSRTTDTFRSEQ 123

Query: 706  SPP--TPQTTLTPLQESPVISKDQSPPPSPPP----------------SYHP-------- 739
              P  +P T      +S    K++      P                  ++P        
Sbjct: 124  KLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSE 183

Query: 740  --PPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSV 797
                  TKK +VV +     E   +P   P    PP P P++Q                 
Sbjct: 184  ASQEETTKKQKVVQKEQGKPEGIIKP---PLQQQPPKPIPKQQG---------------- 224

Query: 798  ASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDP---PPAPPAPAPASSAPGHVAK 854
               +P    G+P+ +SS          ++ QPPG+  P   P   P    A       A 
Sbjct: 225  PGRDPLQQDGTPKSISSQQPEK-----IKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDAS 279

Query: 855  LPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRR 914
             PQ +     +G     E V   L +PS            P   PTP   P A Q    +
Sbjct: 280  RPQTKQADIVRG-----ESVKPSLPSPSK----------PPIQQPTPGK-PPAQQPGHEK 323

Query: 915  ALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIF 974
            +  G A P PA  SGL          LA   G  + +P   P    +PP  P   A    
Sbjct: 324  SQPGPAKP-PAQPSGLTKP-------LAQQPG--TVKPPVQPPGTTKPPAQPLGPAKPPA 373

Query: 975  SK-GSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGV 1033
             + GS K   E+P  P+  A  Q   V +  +  +  P + P +    P P+A++P  G+
Sbjct: 374  QQTGSEKPSSEQP-GPKALA--QPPGVGKTPA-QQPGPAKPPTQQVGTPKPLAQQP--GL 427

Query: 1034 PPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVL----QLVGP 1078
              PA    P   P+  P    +P  Q    +  A+  G      QL GP
Sbjct: 428  QSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGP 476



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 72/313 (23%), Positives = 103/313 (32%), Gaps = 44/313 (14%)

Query: 757  SETAEEPLQDPNWPPPPPPA---PEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVS 813
            +E  +  L +  +  PP      P ++ LS   F   E   F    P    PSGSP + S
Sbjct: 2328 AERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGET--FGQEKPASQLPSGSPSVSS 2385

Query: 814  SPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLP------------QKEPV 861
             PA       +  +     P PPP PP P P    P     LP            +K  V
Sbjct: 2386 LPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTV 2445

Query: 862  GCSKGGGPPREDVGAPLVTPSLLQ-----MVRLRSVGAPGGAPTPALGPSA--------P 908
                    P  D    L T ++L+     + R+ +   P   P P+  PS         P
Sbjct: 2446 ASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEP 2505

Query: 909  QKP---LRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQS 965
             KP    +  +    +    P+        L   S      ++SA    P    P  P S
Sbjct: 2506 SKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHS 2565

Query: 966  PASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPV 1025
              S+  F  S     + +  P  P T  D          S + Q     P  SP +   V
Sbjct: 2566 NKSSPRFSKSLTETYVVITLPSEPGTPTD----------SSASQAITSWPLGSP-SKDLV 2614

Query: 1026 ARKPSVGVPPPAS 1038
            + +P   V PP +
Sbjct: 2615 SVEPVFSVVPPVT 2627



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 81/355 (22%), Positives = 123/355 (34%), Gaps = 83/355 (23%)

Query: 479  RSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPT 538
            + + QL   S S+  L   P P  R+ SL       P  P   PP P     P  P PP 
Sbjct: 2371 KPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPP 2430

Query: 539  TGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQ---------SG 589
            T        +P P       +   SP  +  P      TL  ++   S          + 
Sbjct: 2431 T--------SPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTA 2482

Query: 590  TPTLPPKGLAGP----------PASPGKA-QPPKPERVTSLRSP--------GASVSSSL 630
             P +PPK  + P          P+ P  A +P  P+  T+ + P        G S++SS+
Sbjct: 2483 PPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSM 2542

Query: 631  TSLCSSSSD---PAP-------SDRSGPQILTPLGDRFVI---PPHPKVPA--------- 668
            T    +S+D   P+P       S++S P+    L + +V+   P  P  P          
Sbjct: 2543 TLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAIT 2602

Query: 669  --PFSPPPSKPRSPNP---AAPALAAPAV---------VPGPVSTTDASPQSPPT----P 710
              P   P     S  P     P + A  +         + G + T  A+P + P+     
Sbjct: 2603 SWPLGSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAA 2662

Query: 711  QTTLTPLQESPVISKDQSPPPSPPP-------SYHPPPPPTKKPEVVVEAPSASE 758
             T++T    + V   + S   S  P       S   PP P     + +E P   E
Sbjct: 2663 PTSVTQFLTTEVSKTEVSATRSTAPSVGLSSISITIPPEPLALDNIHLEKPQYKE 2717



 Score = 34.3 bits (77), Expect = 0.66
 Identities = 35/165 (21%), Positives = 56/165 (33%), Gaps = 21/165 (12%)

Query: 673  PPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPS 732
            PP   + P P     ++       V    + P+SP    + ++PL     +     P   
Sbjct: 3586 PPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEK 3645

Query: 733  PPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEE 792
            P P     P     P++    P++ +TA+  +   +   P P +P   + S A F     
Sbjct: 3646 PLPD-DISPQKVLHPDMAKVPPASPKTAK--MMQRSMSDPKPLSPTADESSRAPF----- 3697

Query: 793  AFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPP 837
                    E     GS  + SS A      T         P+PPP
Sbjct: 3698 -----QYTEGYTTKGSQTMTSSGAQKKVKRTL--------PNPPP 3729



 Score = 32.3 bits (72), Expect = 2.5
 Identities = 13/30 (43%), Positives = 15/30 (50%)

Query: 1010 RPPQAPKKSPKAPPPVARKPSVGVPPPASP 1039
            +PP  P   P  PPP    P   +PPP SP
Sbjct: 2404 QPPPPPPPPPPPPPPPPPPPPPPLPPPTSP 2433



 Score = 30.8 bits (68), Expect = 7.3
 Identities = 20/51 (39%), Positives = 21/51 (41%), Gaps = 12/51 (23%)

Query: 1006 ISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLP 1056
            IS Q PP  P   P  PPP         PPP  P  P   P T+P    LP
Sbjct: 2401 ISAQPPPPPP---PPPPPP---------PPPPPPPPPPLPPPTSPKPTILP 2439


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score =  108 bits (270), Expect = 3e-23
 Identities = 177/783 (22%), Positives = 269/783 (34%), Gaps = 156/783 (19%)

Query: 334  PAEPLSPAMSISPQA-TYLSKLIPHAVLPPTVDVV-ALGRCSLRTLSRCSLHSASPASVR 391
            P  P  P +S S    T+ S+       P T+ +  +  R  L+   + S+     + V 
Sbjct: 102  PGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVN 161

Query: 392  SLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSV 451
            +L   SSV +         +  D  S S++S    +    +  K   +G+PE        
Sbjct: 162  ALSAVSSVVNK-------FNPFDLISDSEASQEETTKKQKVVQK--EQGKPEGIIKPPLQ 212

Query: 452  VPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRG 511
              PP+    +  P      +     SI S            K+K  PP           G
Sbjct: 213  QQPPKPIPKQQGPGRDPLQQDGTPKSISSQQP--------EKIKSQPP-----------G 253

Query: 512  LAVP-DGPLGLPPKPERKQ--QPQLPRPPTTGGS--EGAGAAPCPPNPANSWVPGLSPG- 565
               P  GP   P     K   Q    RP T       G    P  P+P+   +   +PG 
Sbjct: 254  TGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGK 313

Query: 566  -------------GSRRPPRSPERTLSPSSGYSSQSGT--PTLPPKGLAGPPASP-GKAQ 609
                         G  +PP  P     P    + Q GT  P + P G   PPA P G A+
Sbjct: 314  PPAQQPGHEKSQPGPAKPPAQPSGLTKP---LAQQPGTVKPPVQPPGTTKPPAQPLGPAK 370

Query: 610  PPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILT-PLGDRFVIPPHPKVPA 668
            PP  +                     + S+   S++ GP+ L  P G   V     + P 
Sbjct: 371  PPAQQ---------------------TGSEKPSSEQPGPKALAQPPG---VGKTPAQQPG 406

Query: 669  PFSPPPSKPRSPNPAA--PALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKD 726
            P  PP  +  +P P A  P L +PA  PGP  T    P   P P   +   Q  P  +  
Sbjct: 407  PAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKT----PVQQPGP-GKIPAQQAGPGKTSA 461

Query: 727  QSPPPSPPPSYHPPP--PPTKKPEVVVEAPSASETAEEPLQDPNWPPPPP-------PAP 777
            Q   P+ PPS  P P  PP ++P      P    +A+ P Q P    PPP       P+P
Sbjct: 462  QQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSP 521

Query: 778  EEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQ--IQPPGSPDP 835
            ++   +      P  A  S   P PA PS      + P + + S   LQ     P +  P
Sbjct: 522  QQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQS--TKPVSQTGSGKPLQPPTVSPSAKQP 579

Query: 836  PP--APPAPAPASSAPGHVAKLPQK---------EPVGCSKGGGPPREDVGAPLVTPSLL 884
            P    P    P  +    +  +P+K         +   CS  G  P          P L 
Sbjct: 580  PSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNP---------NPHLT 630

Query: 885  QMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAAS 944
            ++     +                   ++RAL G  +PVP+         +LK   +  +
Sbjct: 631  EVKEWLCLNC----------------QMKRALGGDLAPVPSSPQ-----PKLKTAPVTTT 669

Query: 945  EGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADL-QRNLVAEL 1003
              +S + P  P +  P+   +P             K  L +   P+    L ++  +   
Sbjct: 670  SAVSKSSPQ-PQQTSPKKDAAP-------------KQDLSKAPEPKKPPPLVKQPTLHGS 715

Query: 1004 RSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTK 1063
             S   ++PP+A   S  APP     PS     P +   P+   +  P T+ +  +   TK
Sbjct: 716  PSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTK 775

Query: 1064 REL 1066
             ++
Sbjct: 776  PDI 778



 Score =  106 bits (264), Expect = 1e-22
 Identities = 171/679 (25%), Positives = 235/679 (34%), Gaps = 134/679 (19%)

Query: 429  GSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPS-----GGSTAEASDTLSIRSSGQ 483
            G+  S +G  EG PE   A+ +      G SG GSPS      G  A+ S  LS     Q
Sbjct: 2    GNEASLEG--EGLPEGLAAAAAA---GGGASGAGSPSHTAIPAGMEADLSQ-LSEEERRQ 55

Query: 484  LSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSE 543
            ++      + L +   PP    S                P   RKQ+     PP   G  
Sbjct: 56   IAAVMSRAQGLPKGSVPPAAAES----------------PSMHRKQELDSSHPPKQSGR- 98

Query: 544  GAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPA 603
                   PP+P     PGLS   +    RS ++                LP +  +    
Sbjct: 99   -------PPDPGRPAQPGLSKSRTTDTFRSEQK----------------LPGRSPSTISL 135

Query: 604  SPGKAQPPKPERVTSLRSPG-ASVSSSLTSLCSSSSDPAP----SDRSGPQILTPLGDRF 658
               K++    E   S   PG  S  ++L+++ S  +   P    SD    Q  T    + 
Sbjct: 136  KESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKV 195

Query: 659  VIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQ 718
            V     K P     PP + + P P  P    P   P      D +P+S  + Q      Q
Sbjct: 196  VQKEQGK-PEGIIKPPLQQQPPKP-IPKQQGPGRDP---LQQDGTPKSISSQQPEKIKSQ 250

Query: 719  ESPVISKDQSPPPSPPPSYHPPP-------PPTKKPEVVVEAPSASETAEEPLQDPNWPP 771
                    Q P  +P   +   P       P TK+ ++V       E+ +  L  P+ PP
Sbjct: 251  PPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIV-----RGESVKPSLPSPSKPP 305

Query: 772  PPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPG 831
               P P +        PP ++     + P PA P   P  ++ P A         +QPPG
Sbjct: 306  IQQPTPGK--------PPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPG 357

Query: 832  SPDPPPAPPAPA-----------PASSAPG--------HVAKLPQKEPVGCSKGGGPPRE 872
            +  PP  P  PA           P+S  PG         V K P ++P G +K   PP +
Sbjct: 358  TTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQP-GPAK---PPTQ 413

Query: 873  DVGAPLVTPSLLQMVRLRS-VGAPGGAPTPALGPSAPQKPLRRALSGRAS---------- 921
             VG P     L Q   L+S   APG   TP   P   + P ++A  G+ S          
Sbjct: 414  QVGTP---KPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPP 470

Query: 922  ---PVPAPSSGLHAAVRLKACSLAASEGLSSAQPNG--PPEAEPRP----PQSPASTASF 972
               P PA                  S    S QP    PP  +P P    PQ P ST   
Sbjct: 471  SQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPP 530

Query: 973  IFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVG 1032
                GS K   ++P   +  A      V++  S    +P Q P  SP A  P    PS G
Sbjct: 531  SQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGS---GKPLQPPTVSPSAKQP----PSQG 583

Query: 1033 VPPPASPSYPRAEPLTAPP 1051
            +P    P     E L   P
Sbjct: 584  LPKTICPLCNTTELLLHVP 602



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 236/1056 (22%), Positives = 363/1056 (34%), Gaps = 211/1056 (19%)

Query: 112  SGRPPHLEELHTQAQEGLRSLQ----HQEKQKLNKGGWDHGDTQSIQSSRTGPDEDNISF 167
            SGRPP   +    AQ GL   +     + +QKL         T S++ S++  D      
Sbjct: 96   SGRPP---DPGRPAQPGLSKSRTTDTFRSEQKLPGRS---PSTISLKESKSRTDLKEEHK 149

Query: 168  CSQTTSYVAESSTAEDALSIRSEMIQRKGSTFRPHDSFPKSGKSGRRRRERRSTVL---- 223
             S    +++E +    ALS  S ++ +    F P D    S  S     +++  V     
Sbjct: 150  SSMMPGFLSEVN----ALSAVSSVVNK----FNPFDLISDSEASQEETTKKQKVVQKEQG 201

Query: 224  ---GL---------PQHVQKELGL-RNEREAPGTPRAPGARDAVRIPTVDGRPRGTSGMG 270
               G+         P+ + K+ G  R+  +  GTP++  ++   +I +   +P GT G  
Sbjct: 202  KPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKS---QPPGT-GKP 257

Query: 271  ARVSLQALEAEAEAGAETEAMLQRHIDR--VYRDDTFVGRSTGTRAP-PLTRPMSLAVPG 327
             +   Q  + +       +  LQR   R    + D   G S     P P   P+    PG
Sbjct: 258  IQGPTQTPQTD-----HAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPG 312

Query: 328  LTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCSLRTLSRCSLHSASP 387
                  P    S      P A       P A  P TV        + +  ++  L  A P
Sbjct: 313  KPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQ-PLGPAKP 371

Query: 388  ASVRSLGRFSSVSSPQPRS-RHPSSSSDTWSH----SQSSDTIVSDGSTLSSKGGSEGQP 442
             + ++     S   P P++   P     T +     ++     V     L+ + G +   
Sbjct: 372  PAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPA 431

Query: 443  ESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPR 502
            ++   + + V  P  G      +G     A  T   +   QL G +       +PPP   
Sbjct: 432  KAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPA-------KPPP--- 481

Query: 503  RTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGL 562
                  Q G A P        KP   QQP   +PP     +   A P P  P ++  P  
Sbjct: 482  -----QQPGPAKPPPQQPGSAKPP-SQQPGSTKPPP---QQPGPAKPSPQQPGSTKPPSQ 532

Query: 563  SPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPK---PERVTSL 619
             PG ++   + P     PS+  S++  + T   K L  P  SP   QPP    P+ +  L
Sbjct: 533  QPGSAKPSAQQPSPA-KPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPL 591

Query: 620  RSPG---------------ASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHP 664
             +                     +++ SLC  + +P          LT + +   +    
Sbjct: 592  CNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPH---------LTEVKEWLCLNCQM 642

Query: 665  K--VPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPV 722
            K  +    +P PS P+           P +   PV+TT A  +S P PQ T      +P 
Sbjct: 643  KRALGGDLAPVPSSPQ-----------PKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPK 691

Query: 723  ISKDQSPPPSPPP---------------SYHPP-------PPPTKKPEVVVEAPSASETA 760
                ++P P  PP               +  PP       P P K+P V  E   A    
Sbjct: 692  QDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVAD 751

Query: 761  EEPLQDPNWPPPP-----------PPAPEEQDLSMAD-----------------FPPPEE 792
            ++P Q     P             P  P  +  S A+                 FPP  E
Sbjct: 752  DKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGE 811

Query: 793  A---FFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAP 849
                F S A P PA  S   +++S P  SS S    Q+ P    +     P  A    +P
Sbjct: 812  KVSPFDSKAIPRPASDS---KIISHPGPSSESKGQKQVDPVQKKE----EPKKAQTKMSP 864

Query: 850  GHVAKLPQKEPVGCSKGGGP---PREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPS 906
               AK     P G     GP     + V  P  +P   +  R  S+        P   P+
Sbjct: 865  KPDAK---PMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPT 921

Query: 907  APQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEG-LSSAQPNGPPEAEPRPPQS 965
             PQ+ +   L G  + + + +S L         S A   G  S + P  P +  P P Q 
Sbjct: 922  TPQETVTGKLFGFGASIFSQASNL--------ISTAGQPGPHSQSGPGAPMKQAPAPSQP 973

Query: 966  PASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKA--PP 1023
            P        S+G  K   + P +P     +++          E + P A K  PKA   P
Sbjct: 974  PT-------SQGPPKSTGQAPPAPAKSIPVKK----------ETKAPAAEKLEPKAEQAP 1016

Query: 1024 PVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQ 1059
             V R  +   PPP   S    + LTA P   +  T+
Sbjct: 1017 TVKRTETEKKPPPIKDS----KSLTAEPQKAVLPTK 1048



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 92/356 (25%), Positives = 121/356 (33%), Gaps = 46/356 (12%)

Query: 622  PGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPN 681
            P + + S   S+ S  + P P  RS         D    PP P  P P  PPP  P  P 
Sbjct: 2372 PASQLPSGSPSVSSLPAKPRPFFRSSSL------DISAQPPPPPPPPPPPPPPPPPPPPP 2425

Query: 682  PAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPP 741
            P  P  +    +      T ASP +  TP        E+  + +    P +   +  PPP
Sbjct: 2426 PLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPP 2485

Query: 742  PPTKKPEVVVEAPSASETAEEPLQDPNWPP--PPPPAPEEQDLSM--ADFPPPEEAFFSV 797
             P K   +    PS       P  +P+ PP  P P  P+    +    D  P        
Sbjct: 2486 VPPKPSSI----PSGLVFTHRP--EPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLT 2539

Query: 798  AS-------------PEPAGPSGSPELVSSPAASSS-SATALQIQPPGSPDPPPAPPAPA 843
            +S             P P  P       SSP  S S + T + I  P  P  P    A  
Sbjct: 2540 SSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQ 2599

Query: 844  PASSAP-GHVAK-LPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTP 901
              +S P G  +K L   EPV       PP   V  P+ +     +    S      + TP
Sbjct: 2600 AITSWPLGSPSKDLVSVEPVFSVV---PPVTAVEIPISSEQTFYI----SGALQTFSATP 2652

Query: 902  ALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPE 957
               PS+ Q           + V   S    +A R    S A S GLSS     PPE
Sbjct: 2653 VTAPSSFQAAPTSVTQFLTTEV---SKTEVSATR----STAPSVGLSSISITIPPE 2701



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 161/764 (21%), Positives = 236/764 (30%), Gaps = 156/764 (20%)

Query: 381  SLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDT-----IVSDGSTLSSK 435
            +LH +  A  +      S+S P P  + PS  S+      + D      +V   + L S 
Sbjct: 711  TLHGSPSAKAKQPPEADSLSKPAP-PKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSS 769

Query: 436  GGSEGQPE------SSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSV 489
              +  +P+       S A     PP +  S + S S   T E       ++      R  
Sbjct: 770  SSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIP----RPA 825

Query: 490  SLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAP 549
            S  K+   P P     S   +G    D P+    +P++ Q    P+P      +G+   P
Sbjct: 826  SDSKIISHPGP-----SSESKGQKQVD-PVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPP 879

Query: 550  CPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQ 609
             P   A   VP  +P  S +P     R       +S   G+ T  PK           +Q
Sbjct: 880  GPRPTAGQTVP--TPQQSPKPQEQSRR-------FSLNLGSITDAPK-----------SQ 919

Query: 610  PPKPERVTS--LRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPH---- 663
            P  P+   +  L   GAS+ S  ++L S++  P P  +SGP            PP     
Sbjct: 920  PTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGP 979

Query: 664  PKV-----PAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPT--------- 709
            PK      PAP    P K  +  PAA  L   A     V  T+   + PP          
Sbjct: 980  PKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAE 1039

Query: 710  PQTTLTP--LQESPVISKDQSPPP----------SPPPSYH----------------PPP 741
            PQ  + P  L++SP   K +S  P            PP+++                P P
Sbjct: 1040 PQKAVLPTKLEKSP---KPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTP 1096

Query: 742  PPTKKPEVVVEAPSASETAEEPLQDPNWPPPPP--------PAPEEQDLSMADFPPP--- 790
              T+  E +             L D    PP P        P P E        PP    
Sbjct: 1097 HLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKL 1156

Query: 791  -----------EEAFFSVASPEPAGPSGSPELVSSPAASSSS------ATALQIQPPGSP 833
                        E        E       P +V++      S      A+ALQ + P   
Sbjct: 1157 VKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPE 1216

Query: 834  DPPPAP------------------PAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVG 875
            +    P                  P P      P      P+++     K      E+  
Sbjct: 1217 EKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKL 1276

Query: 876  APLVTPSLLQ---MVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHA 932
               V P  +Q     + +  G P G  TP   P    K  +        P  A    +  
Sbjct: 1277 EGRVAPKTVQEGKQPQTKMEGLPSG--TPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEP 1334

Query: 933  AVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASF------------IFSKGSRK 980
                       S+  SS QP  P         S   ++S                KG +K
Sbjct: 1335 GKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKK 1394

Query: 981  LQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPP 1024
                +  SP + +DL +     L  +  Q    A +KS K   P
Sbjct: 1395 DSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQP 1438



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 127/529 (24%), Positives = 182/529 (34%), Gaps = 110/529 (20%)

Query: 595  PKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPL 654
            P+GLA   A+ G A        T++    A + + L+ L         +  S  Q L P 
Sbjct: 13   PEGLAAAAAAGGGASGAGSPSHTAIP---AGMEADLSQLSEEERRQIAAVMSRAQGL-PK 68

Query: 655  GDRFVIPP--------HPKVPAPFSPPPSKP-RSPNPAAPALAAPAVVPGPVSTTDASPQ 705
            G    +PP        H K     S PP +  R P+P  PA   P +     + T  S Q
Sbjct: 69   GS---VPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPA--QPGLSKSRTTDTFRSEQ 123

Query: 706  SPP--TPQTTLTPLQESPVISKDQSPPPSPPP----------------SYHP-------- 739
              P  +P T      +S    K++      P                  ++P        
Sbjct: 124  KLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSE 183

Query: 740  --PPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSV 797
                  TKK +VV +     E   +P   P    PP P P++Q                 
Sbjct: 184  ASQEETTKKQKVVQKEQGKPEGIIKP---PLQQQPPKPIPKQQG---------------- 224

Query: 798  ASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDP---PPAPPAPAPASSAPGHVAK 854
               +P    G+P+ +SS          ++ QPPG+  P   P   P    A       A 
Sbjct: 225  PGRDPLQQDGTPKSISSQQPEK-----IKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDAS 279

Query: 855  LPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRR 914
             PQ +     +G     E V   L +PS            P   PTP   P A Q    +
Sbjct: 280  RPQTKQADIVRG-----ESVKPSLPSPSK----------PPIQQPTPGK-PPAQQPGHEK 323

Query: 915  ALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIF 974
            +  G A P PA  SGL          LA   G  + +P   P    +PP  P   A    
Sbjct: 324  SQPGPAKP-PAQPSGLTKP-------LAQQPG--TVKPPVQPPGTTKPPAQPLGPAKPPA 373

Query: 975  SK-GSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGV 1033
             + GS K   E+P  P+  A  Q   V +  +  +  P + P +    P P+A++P  G+
Sbjct: 374  QQTGSEKPSSEQP-GPKALA--QPPGVGKTPA-QQPGPAKPPTQQVGTPKPLAQQP--GL 427

Query: 1034 PPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVL----QLVGP 1078
              PA    P   P+  P    +P  Q    +  A+  G      QL GP
Sbjct: 428  QSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGP 476



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 72/313 (23%), Positives = 103/313 (32%), Gaps = 44/313 (14%)

Query: 757  SETAEEPLQDPNWPPPPPPA---PEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVS 813
            +E  +  L +  +  PP      P ++ LS   F   E   F    P    PSGSP + S
Sbjct: 2328 AERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGET--FGQEKPASQLPSGSPSVSS 2385

Query: 814  SPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLP------------QKEPV 861
             PA       +  +     P PPP PP P P    P     LP            +K  V
Sbjct: 2386 LPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTV 2445

Query: 862  GCSKGGGPPREDVGAPLVTPSLLQ-----MVRLRSVGAPGGAPTPALGPSA--------P 908
                    P  D    L T ++L+     + R+ +   P   P P+  PS         P
Sbjct: 2446 ASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEP 2505

Query: 909  QKP---LRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQS 965
             KP    +  +    +    P+        L   S      ++SA    P    P  P S
Sbjct: 2506 SKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHS 2565

Query: 966  PASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPV 1025
              S+  F  S     + +  P  P T  D          S + Q     P  SP +   V
Sbjct: 2566 NKSSPRFSKSLTETYVVITLPSEPGTPTD----------SSASQAITSWPLGSP-SKDLV 2614

Query: 1026 ARKPSVGVPPPAS 1038
            + +P   V PP +
Sbjct: 2615 SVEPVFSVVPPVT 2627



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 81/355 (22%), Positives = 123/355 (34%), Gaps = 83/355 (23%)

Query: 479  RSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPT 538
            + + QL   S S+  L   P P  R+ SL       P  P   PP P     P  P PP 
Sbjct: 2371 KPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPP 2430

Query: 539  TGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQ---------SG 589
            T        +P P       +   SP  +  P      TL  ++   S          + 
Sbjct: 2431 T--------SPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTA 2482

Query: 590  TPTLPPKGLAGP----------PASPGKA-QPPKPERVTSLRSP--------GASVSSSL 630
             P +PPK  + P          P+ P  A +P  P+  T+ + P        G S++SS+
Sbjct: 2483 PPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSM 2542

Query: 631  TSLCSSSSD---PAP-------SDRSGPQILTPLGDRFVI---PPHPKVPA--------- 668
            T    +S+D   P+P       S++S P+    L + +V+   P  P  P          
Sbjct: 2543 TLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAIT 2602

Query: 669  --PFSPPPSKPRSPNP---AAPALAAPAV---------VPGPVSTTDASPQSPPT----P 710
              P   P     S  P     P + A  +         + G + T  A+P + P+     
Sbjct: 2603 SWPLGSPSKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAA 2662

Query: 711  QTTLTPLQESPVISKDQSPPPSPPP-------SYHPPPPPTKKPEVVVEAPSASE 758
             T++T    + V   + S   S  P       S   PP P     + +E P   E
Sbjct: 2663 PTSVTQFLTTEVSKTEVSATRSTAPSVGLSSISITIPPEPLALDNIHLEKPQYKE 2717



 Score = 34.3 bits (77), Expect = 0.66
 Identities = 35/165 (21%), Positives = 56/165 (33%), Gaps = 21/165 (12%)

Query: 673  PPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPS 732
            PP   + P P     ++       V    + P+SP    + ++PL     +     P   
Sbjct: 3586 PPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEK 3645

Query: 733  PPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEE 792
            P P     P     P++    P++ +TA+  +   +   P P +P   + S A F     
Sbjct: 3646 PLPD-DISPQKVLHPDMAKVPPASPKTAK--MMQRSMSDPKPLSPTADESSRAPF----- 3697

Query: 793  AFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPP 837
                    E     GS  + SS A      T         P+PPP
Sbjct: 3698 -----QYTEGYTTKGSQTMTSSGAQKKVKRTL--------PNPPP 3729



 Score = 32.3 bits (72), Expect = 2.5
 Identities = 13/30 (43%), Positives = 15/30 (50%)

Query: 1010 RPPQAPKKSPKAPPPVARKPSVGVPPPASP 1039
            +PP  P   P  PPP    P   +PPP SP
Sbjct: 2404 QPPPPPPPPPPPPPPPPPPPPPPLPPPTSP 2433



 Score = 30.8 bits (68), Expect = 7.3
 Identities = 20/51 (39%), Positives = 21/51 (41%), Gaps = 12/51 (23%)

Query: 1006 ISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLP 1056
            IS Q PP  P   P  PPP         PPP  P  P   P T+P    LP
Sbjct: 2401 ISAQPPPPPP---PPPPPP---------PPPPPPPPPPLPPPTSPKPTILP 2439


>gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]
          Length = 1003

 Score =  106 bits (265), Expect = 1e-22
 Identities = 153/553 (27%), Positives = 200/553 (36%), Gaps = 112/553 (20%)

Query: 530  QPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSG 589
            +P    PPTT  + G G+ P  P   +   P L+  G   PPR  +    PS G SS   
Sbjct: 146  RPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPTLAGPGGLFPPRLADPV--PSGGSSS--- 200

Query: 590  TPTLPPKGLAGPPASPGKAQPPKPERVTSLRSP----GASVSSSLTSLCSSSSDPAPSDR 645
             P   P+G A  PA      PP P  + SL +P    GA++ SSL       S PAP   
Sbjct: 201  -PRFLPRGNAPSPA------PPPPPAI-SLNAPSYNWGAALRSSLVP-SDLGSPPAPHAS 251

Query: 646  SGPQILTPL---GDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPV--STT 700
            S P    PL    D    PP P  P+   P    P S  P + A     +V GP+  + T
Sbjct: 252  SSPPSDPPLFHCSDALTPPPLP--PSNNLPAHPGPASQPPVSSATMHLPLVLGPLGGAPT 309

Query: 701  DASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEA---PSAS 757
               P +PP   ++L         +K Q PP  PP +     P  + P     +   PS  
Sbjct: 310  VEGPGAPPFLASSLLS-----AAAKAQHPPLPPPSTLQGRRPRAQAPSASHSSSLRPSQR 364

Query: 758  ETAEEPL----------QDPNWPPPPPPAPEEQDLSMAD----FPPPEEAFFSVASPEPA 803
                 P           Q P    P  PAP  Q  S+ +      P   +   + +P P+
Sbjct: 365  RPRRPPTVFRLLEGRGPQTPRRSRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPTPGPS 424

Query: 804  GPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGC 863
               GS  L+ S A      T       GSP  P  P  P+   +  G ++ +P       
Sbjct: 425  HSDGSFNLLGSDAHLPPPPTLSS----GSPPQPRHPIQPSLPGTTSGSLSSVP------- 473

Query: 864  SKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPV 923
              G   P     AP+V   +LQ     S G   GA     GP+ P  PL     G A P 
Sbjct: 474  --GAPAPPAASKAPVVPSPVLQSP---SEGLGMGA-----GPACPLPPLA---GGEAFPF 520

Query: 924  PAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQL 983
            P+P  GL       A S A   G+  A P   P +  +PP SP                 
Sbjct: 521  PSPEQGL-------ALSGAGFPGMLGALPL--PLSLGQPPPSPL---------------- 555

Query: 984  ERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPR 1043
                       L  +L   L     Q PP+     P  PPP    P +    P  PS   
Sbjct: 556  -----------LNHSLFGVLTGGGGQPPPE-----PLLPPPGGPGPPLAPGEPEGPSLLV 599

Query: 1044 AEPLTAPPTNGLP 1056
            A  L  PP++ LP
Sbjct: 600  ASLLPPPPSDLLP 612



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 201/807 (24%), Positives = 273/807 (33%), Gaps = 174/807 (21%)

Query: 310  TGTRAPPLTRPMSLAVPG--LTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTV--D 365
            T +  PP  RP     P   L GG G   P  P++S      + +   P  + PP +   
Sbjct: 137  TVSPGPPSARPPCRVPPTTPLNGGPGSLPPEPPSVS----QAFPTLAGPGGLFPPRLADP 192

Query: 366  VVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTI 425
            V + G  S R L R +  S +P              P P +   ++ S  W  +  S  +
Sbjct: 193  VPSGGSSSPRFLPRGNAPSPAP--------------PPPPAISLNAPSYNWGAALRSSLV 238

Query: 426  VSDGSTLSSKGGSEGQPESST---ASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSG 482
             SD  +  +   S   P        S+++ PPP   S       G  ++           
Sbjct: 239  PSDLGSPPAPHASSSPPSDPPLFHCSDALTPPPLPPSNNLPAHPGPASQ----------- 287

Query: 483  QLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGS 542
                             PP  + ++H   L +  GPLG  P  E    P  P    +   
Sbjct: 288  -----------------PPVSSATMH---LPLVLGPLGGAPTVEG---PGAPPFLASSLL 324

Query: 543  EGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPP---KGLA 599
              A  A  PP P  S + G       R PR+   + S SS        P  PP   + L 
Sbjct: 325  SAAAKAQHPPLPPPSTLQG-------RRPRAQAPSASHSSSLRPSQRRPRRPPTVFRLLE 377

Query: 600  GP-PASPGKAQPPKPERVT---SLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLG 655
            G  P +P +++P  P  V    SL  P   +  S+ SL    + P PS   G   L  LG
Sbjct: 378  GRGPQTPRRSRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPT-PGPSHSDGSFNL--LG 434

Query: 656  DRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLT 715
                +PP P + +   P P  P  P+        P    G +S+    P +P  P  +  
Sbjct: 435  SDAHLPPPPTLSSGSPPQPRHPIQPS-------LPGTTSGSLSSV---PGAPAPPAASKA 484

Query: 716  PLQESPVISKDQSP---------PPSP-PPSYHPPPPPTKKPEVVVEAPSAS---ETAEE 762
            P+  SPV+   QSP         P  P PP       P   PE  +    A         
Sbjct: 485  PVVPSPVL---QSPSEGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGAL 541

Query: 763  PLQDPNWPPPPPPAPEEQDLSM----ADFPPPEEAFFSVASPEPAGPSGSPELVSSPAAS 818
            PL      PPP P        +       PPPE        P P GP G P     P   
Sbjct: 542  PLPLSLGQPPPSPLLNHSLFGVLTGGGGQPPPEPLL-----PPPGGP-GPPLAPGEPEGP 595

Query: 819  SSSATALQIQPPGSPDPPP-APPAPAPASSAP----GHVAKLPQKEPVGCSKGGGPPRED 873
            S    +L   PP    PPP APP+   AS  P    G  A   +    G     G P   
Sbjct: 596  SLLVASLLPPPPSDLLPPPSAPPSNLLASFLPLLALGPTAGDGEGSAEGAGGPSGEPFSG 655

Query: 874  VG--APLVTPSLLQ---MVRLRS------VGAPGGAPTPALGPSAPQ------------- 909
            +G  +PL+ P L     ++ L S      +  P G P      SAPQ             
Sbjct: 656  LGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAPQPGPPTSSVTTATT 715

Query: 910  ----KPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGL--SSAQPNGP-------- 955
                  L +A S    P    S  L A++     SL +S G   S  QP GP        
Sbjct: 716  DPGASSLGKAPSNSGRPPQLLSPLLGASLLGDLSSLTSSPGALPSLLQPPGPLLSGQLGL 775

Query: 956  ---PEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPP 1012
               P     PP S AS+      + S ++  E+P +P                +  + P 
Sbjct: 776  QLLPGGGAPPPLSEASSPLACLLQ-SLQIPPEQPEAP---------------CLPPESPA 819

Query: 1013 QAPKKSPKAPPPVARKPSVGVPPPASP 1039
             A +  P  PP  A  P  G P P  P
Sbjct: 820  SALEPEPARPPLSALAPPHGSPDPPVP 846



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 123/492 (25%), Positives = 165/492 (33%), Gaps = 115/492 (23%)

Query: 602  PASPGKAQ--PPKPERVTSL---RSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGD 656
            P +PG A   P   E +T L   R    ++++   S+ ++ S  +P + + PQ+      
Sbjct: 81   PVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMF----- 135

Query: 657  RFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTP 716
              V P  P    P   PP+ P +  P +       + P P S + A P +   P     P
Sbjct: 136  HTVSPGPPSARPPCRVPPTTPLNGGPGS-------LPPEPPSVSQAFP-TLAGPGGLFPP 187

Query: 717  LQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPS----------------ASETA 760
                PV S   S P   P    P P P   P + + APS                 S  A
Sbjct: 188  RLADPVPSGGSSSPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPA 247

Query: 761  EEPLQDPNWPPP---------PPPAPEEQDLSM----ADFPPPEEAFFSVASPEPAGPSG 807
                  P   PP         PPP P   +L      A  PP   A   +  P   GP G
Sbjct: 248  PHASSSPPSDPPLFHCSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHL--PLVLGPLG 305

Query: 808  SPELVSSPAA-----SSSSATALQIQPPGSPDPPPA------PPAPAPASSAPGHVA--- 853
                V  P A     SS  + A + Q P  P PPP+      P A AP++S    +    
Sbjct: 306  GAPTVEGPGAPPFLASSLLSAAAKAQHP--PLPPPSTLQGRRPRAQAPSASHSSSLRPSQ 363

Query: 854  KLPQKEPV--GCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKP 911
            + P++ P      +G GP               Q  R     AP   P P   P   Q  
Sbjct: 364  RRPRRPPTVFRLLEGRGP---------------QTPRRSRPRAPAPVPQPFSLPEPSQPI 408

Query: 912  LRRALSGRASPVPAPSSGLHAAVRLKA-CSLAASEGLSSAQPNGPPEAEPRPPQSPASTA 970
            L   LS    P P PS    +   L +   L     LSS  P  P    P  P  P +T+
Sbjct: 409  LPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPTLSSGSP--PQPRHPIQPSLPGTTS 466

Query: 971  SFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPS 1030
                                            L S+     P A  K+P  P PV + PS
Sbjct: 467  G------------------------------SLSSVPGAPAPPAASKAPVVPSPVLQSPS 496

Query: 1031 VGVPPPASPSYP 1042
             G+   A P+ P
Sbjct: 497  EGLGMGAGPACP 508



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 112/445 (25%), Positives = 154/445 (34%), Gaps = 68/445 (15%)

Query: 397 SSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTAS---NSVVP 453
           SS S PQPR  HP   S   + S S          LSS  G+   P +S A    + V+ 
Sbjct: 446 SSGSPPQPR--HPIQPSLPGTTSGS----------LSSVPGAPAPPAASKAPVVPSPVLQ 493

Query: 454 PPQGGSGRGS-------PSGGSTA------EASDTLSIRSSGQLSGRSVSLRKLKRPPPP 500
            P  G G G+       P  G  A      E    LS      + G       L +PPP 
Sbjct: 494 SPSEGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPS 553

Query: 501 PRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGS-EGAG---AAPCPPNPAN 556
           P   HSL      V  G  G PP       P  P PP   G  EG     A+  PP P++
Sbjct: 554 PLLNHSL----FGVLTGGGGQPPPEPLLPPPGGPGPPLAPGEPEGPSLLVASLLPPPPSD 609

Query: 557 SWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQ------- 609
              P  +P  +      P   L P++G    S       +G  GP   P           
Sbjct: 610 LLPPPSAPPSNLLASFLPLLALGPTAGDGEGSA------EGAGGPSGEPFSGLGDLSPLL 663

Query: 610 -PPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPA 668
            PP     T +    A ++++L     S + P P   S PQ   P          P   +
Sbjct: 664 FPPLSAPPTLIALNSALLAATLDP--PSGTPPQPCVLSAPQPGPPTSSVTTATTDPGASS 721

Query: 669 PFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQS 728
               P +  R P   +P L A  +  G +S+  +SP + P+      PL    +  +   
Sbjct: 722 LGKAPSNSGRPPQLLSPLLGASLL--GDLSSLTSSPGALPSLLQPPGPLLSGQLGLQLLP 779

Query: 729 PPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFP 788
              +PPP              + EA S      + LQ P   P  P  P E   S  +  
Sbjct: 780 GGGAPPP--------------LSEASSPLACLLQSLQIPPEQPEAPCLPPESPASALEPE 825

Query: 789 PPEEAFFSVASPEPAGPSGSPELVS 813
           P      ++A P  +     PEL++
Sbjct: 826 PARPPLSALAPPHGSPDPPVPELLT 850



 Score = 34.7 bits (78), Expect = 0.51
 Identities = 46/181 (25%), Positives = 64/181 (35%), Gaps = 14/181 (7%)

Query: 441 QPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPP 500
           +PE +    S + PP G      P    T   S     R  G L G +   R  +   P 
Sbjct: 823 EPEPARPPLSALAPPHGSPDPPVPEL-LTGRGSGKRGRRGGGGLRGINGEARPARGRKPG 881

Query: 501 PRRTHSLHQRGLAVPDGPLG-----LPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPA 555
            RR        LA+  G  G     +   P R    Q       GG+E     P  P+  
Sbjct: 882 SRREPGR----LALKWGTRGGFNGQMERSPRRTHHWQHNGELAEGGAEPKDPPPPGPHSE 937

Query: 556 NSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPAS-PGKAQPPKPE 614
           +  VP   PG  R+  R   R  +P+   +S     TL P   A      P +A+P +P 
Sbjct: 938 DLKVP---PGVVRKSRRGRRRKYNPTRNSNSSRQDITLEPSPTARAAVPLPPRARPGRPA 994

Query: 615 R 615
           +
Sbjct: 995 K 995


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score =  105 bits (263), Expect = 2e-22
 Identities = 96/381 (25%), Positives = 137/381 (35%), Gaps = 42/381 (11%)

Query: 497  PPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPR----PPTTGGSEGAGAAPCPP 552
            P PPP  T +L       P       P P     P +      PPTT  S        PP
Sbjct: 1406 PSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTTTTPP 1465

Query: 553  NPANSWVPGLSPGGSRRPPRSPERTLS---PSSGYSSQSGTP--------TLPPKGLAGP 601
                   P  +P      P  P  T +   P++  S  + TP        TLPP     P
Sbjct: 1466 PTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSP 1525

Query: 602  PASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIP 661
            P +     PP         +P    +S+ T   +++  P P+  + P   T         
Sbjct: 1526 PTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTT 1585

Query: 662  PHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESP 721
            P P      +PPP+   SP         P   P P +TT   P +PPT  TTL P     
Sbjct: 1586 PSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTT---PITPPTSTTTLPP----- 1637

Query: 722  VISKDQSPPP----SPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAP 777
              +   SPPP    +PPP+  P PP T  P      P  + T   P   P+ P    P+P
Sbjct: 1638 --TTTPSPPPTTTTTPPPTTTPSPPTTTTP----SPPITTTTTPPPTTTPSSPITTTPSP 1691

Query: 778  EEQDLSM-ADFPPPEEAFFSVASP-EPAGPSGSPELVSSPAAS---SSSATALQIQPPGS 832
                ++  +    P     +  +P     PS  P  +++P+ +   S   T +   PP +
Sbjct: 1692 PTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTT 1751

Query: 833  PDPP----PAPPAPAPASSAP 849
               P    P PP+  P + +P
Sbjct: 1752 TSSPLTTTPLPPSITPPTFSP 1772



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 93/371 (25%), Positives = 144/371 (38%), Gaps = 51/371 (13%)

Query: 564  PGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLA-GPPASPGKAQPPKPERVTSLRSP 622
            P  +  PP +   TL P++  S  + T T PP      PP +     PP         +P
Sbjct: 1402 PTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPP-------TTTP 1454

Query: 623  GASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNP 682
               +S++ T   +++  P P+    P   TP          P    P SPP + P +P P
Sbjct: 1455 SPPISTTTTPPPTTTPSP-PTTTPSPPTTTPSPPTTTTTTPPPTTTP-SPPTTTPITP-P 1511

Query: 683  AAPALAAPAVVPGPVSTTDASPQSPPTPQ-TTLTPLQESPVISKDQSPP---PSPPPSYH 738
            A+     P   P P +TT  +P    TP   T TP+  +P  S    PP   PSPPP+  
Sbjct: 1512 ASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPI--TPPTSTTTLPPTTTPSPPPTTT 1569

Query: 739  PPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPP-PPPAPEEQDLSMADFPPPEEAFFSV 797
              PPPT  P     +P  + T   P      PPP   P+P     +    PPP       
Sbjct: 1570 TTPPPTTTP-----SPPTTTTPSPPTITTTTPPPTTTPSP---PTTTTTTPPP------- 1614

Query: 798  ASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQ 857
             +  P+ P+ +P  ++ P ++++      + P  +P PPP      P ++ P        
Sbjct: 1615 -TTTPSPPTTTP--ITPPTSTTT------LPPTTTPSPPPTTTTTPPPTTTPSPPTTTTP 1665

Query: 858  KEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALS 917
              P+  +    PP     +P+ T        + +       P+P   PS+P        S
Sbjct: 1666 SPPI-TTTTTPPPTTTPSSPITTTPSPPTTTMTT-------PSPTTTPSSPITTTTTP-S 1716

Query: 918  GRASPVPAPSS 928
               +P P P++
Sbjct: 1717 STTTPSPPPTT 1727



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 153/816 (18%), Positives = 271/816 (33%), Gaps = 104/816 (12%)

Query: 304  TFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAE-PLSPAMSISPQATYLSKLIPHAVLPP 362
            T  G  T T  P  T       P  TG   P   P++   +++P  T      P     P
Sbjct: 3499 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTP 3552

Query: 363  TVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSS 422
            T   +        T +     + +   + +    ++  +P P    P+ +    +   ++
Sbjct: 3553 TTTPITTTTTVTPTPTPTGTQTPTTTPITT----TTTVTPTPT---PTGTQTPTTTPITT 3605

Query: 423  DTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSG 482
             T V+   T +        P ++T + +  P P G     +    +T   + T +   + 
Sbjct: 3606 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3665

Query: 483  QLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGS 542
              +   ++      P P P  T +     +        + P P     P   + PTT   
Sbjct: 3666 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT---VTPTPT----PTGTQTPTTTPI 3718

Query: 543  EGAGAAPCPPNPANSWVPGLSPGGSRR---PPRSPERTLSPSSG--YSSQSGTPTLPPKG 597
                     P P  +  P  +P  +     P  +P  T +P++    ++ + TPT  P G
Sbjct: 3719 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3778

Query: 598  LAGPPASP---GKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPL 654
               P  +P        P P   T  ++P    ++ +T+  + +  P P+    P   TP+
Sbjct: 3779 TQTPTTTPITTTTTVTPTPTP-TGTQTP---TTTPITTTTTVTPTPTPTGTQTPTT-TPI 3833

Query: 655  GDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTL 714
                 + P        +P P+  ++P    P      V P P  T   +P +  TP TT 
Sbjct: 3834 TTTTTVTP--------TPTPTGTQTPT-TTPITTTTTVTPTPTPTGTQTPTT--TPITTT 3882

Query: 715  TPLQESPVISKDQSPPPSP---PPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPP 771
            T +  +P  +  Q+P  +P     +  P P PT   +     P  + T   P   P    
Sbjct: 3883 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-QTPTTTPITTTTTVTPTPTPTGTQ 3941

Query: 772  PPPPAPEEQDLSMADFPPPEEA---------FFSVASPEPAGPSGSPELVSSPAASSSSA 822
             P   P     ++   P P              +  +P P  P+G+    ++P  ++++ 
Sbjct: 3942 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-PTGTQTPTTTPITTTTTV 4000

Query: 823  TALQIQPPGSPDPPPAP--------PAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDV 874
            T     P G+  P   P        P P P  +      + P   P+  +    P     
Sbjct: 4001 TPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGT------QTPTTTPITTTTTVTPTPTPT 4053

Query: 875  GAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAV 934
            G    TP+   +    +V      PTP   P+  Q P    ++   +  P P+       
Sbjct: 4054 GTQ--TPTTTPITTTTTV-----TPTPT--PTGTQTPTTTPITTTTTVTPTPTP-----T 4099

Query: 935  RLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQAD 994
              +  +       ++  P   P     P  +P +T + +    +       P   +T   
Sbjct: 4100 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQTPTT 4152

Query: 995  LQRNLVAELRSISEQRPPQAPKKSP------KAPPPVARKPSVGVPPPASPSYPRAEPLT 1048
                    +         Q P  +P        P P       G PP  + + P AE  T
Sbjct: 4153 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTG-PPTHTSTAPIAELTT 4211

Query: 1049 A--PPTNGLPHTQDRTKRELAENGGVLQLVGPEEKM 1082
            +  PP +  P T   T   L E+  +L  + P  +M
Sbjct: 4212 SNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEM 4247



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 161/768 (20%), Positives = 260/768 (33%), Gaps = 124/768 (16%)

Query: 304  TFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAE-PLSPAMSISPQATYLSKLIPHAVLPP 362
            T  G  T T  P  T       P  TG   P   P++   +++P  T      P     P
Sbjct: 3752 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTP 3805

Query: 363  TVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSS 422
            T   +        T +     + +   + +    ++  +P P    P+ +    +   ++
Sbjct: 3806 TTTPITTTTTVTPTPTPTGTQTPTTTPITT----TTTVTPTPT---PTGTQTPTTTPITT 3858

Query: 423  DTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSG 482
             T V+   T +        P ++T + +  P P G     +    +T   + T +   + 
Sbjct: 3859 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3918

Query: 483  QLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGS 542
              +   ++      P P P  T +     +        + P P     P   + PTT   
Sbjct: 3919 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT---VTPTPT----PTGTQTPTTTPI 3971

Query: 543  EGAGAAPCPPNPANSWVPGLSPGGSRR---PPRSPERTLSPSSG--YSSQSGTPTLPPKG 597
                     P P  +  P  +P  +     P  +P  T +P++    ++ + TPT  P G
Sbjct: 3972 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 4031

Query: 598  LAGPPASP---GKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPL 654
               P  +P        P P   T  ++P    ++ +T+  + +  P P+    P   TP+
Sbjct: 4032 TQTPTTTPITTTTTVTPTPTP-TGTQTP---TTTPITTTTTVTPTPTPTGTQTPTT-TPI 4086

Query: 655  GDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPP-TPQTT 713
                 + P        +P P+  ++P    P      V P P  T   +P + P T  TT
Sbjct: 4087 TTTTTVTP--------TPTPTGTQTPT-TTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 4137

Query: 714  LTPLQESPVISKDQSPPPSP---PPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWP 770
            +TP   +P  +  Q+P  +P     +  P P PT   +     P  + T   P   P   
Sbjct: 4138 VTP---TPTPTGTQTPTTTPITTTTTVTPTPTPT-GTQTPTTTPITTTTTVTPTPTPTGT 4193

Query: 771  PPPPPAPEE----QDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQ 826
               PP         +L+ ++ PPPE      ++P+ +  + SP         + S T L 
Sbjct: 4194 QTGPPTHTSTAPIAELTTSN-PPPES-----STPQTSRSTSSP--------LTESTTLLS 4239

Query: 827  IQPPGSPDPPPAPPA--PAPASSAPGHVAKLPQKEPVGCSKGGGPPREDV--GAPLVTPS 882
              PP       APP+   AP +++ GH    P       S  G P R      +   TPS
Sbjct: 4240 TLPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTT--SPPGTPTRGTTTGSSSAPTPS 4297

Query: 883  LLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLA 942
             +Q     +  A    PTP   PS  +    R         P PSS L   V L     A
Sbjct: 4298 TVQTT---TTSAWTPTPTPLSTPSIIRTTGLR---------PYPSSVLICCV-LNDTYYA 4344

Query: 943  ASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAE 1002
              E + +               +   T  F+    S  L+      P T +         
Sbjct: 4345 PGEEVYNG--------------TYGDTCYFVNCSLSCTLEFYNWSCPSTPS--------- 4381

Query: 1003 LRSISEQRPPQAPKKS---PKAPPPVARKPSVGVPPPASPSY--PRAE 1045
                    P   P KS   P  P     KP+ G  PP  P +  PR E
Sbjct: 4382 --------PTPTPSKSTPTPSKPSSTPSKPTPGTKPPECPDFDPPRQE 4421



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 82/368 (22%), Positives = 117/368 (31%), Gaps = 121/368 (32%)

Query: 694  PGPVSTTDASPQSPPTPQTTLTPLQE-SPVISKDQSPPP----SPPPSYHPPPPPTKKPE 748
            P P +TT   P  PPT  TTL P    SP  +   +PPP    SPP +    PPPT  P 
Sbjct: 1399 PSPPTTT---PSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPS 1455

Query: 749  VVVEAPSASETAEEPLQDPNWP---PPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGP 805
                 P ++ T   P   P+ P   P PP        +    PPP        +  P+ P
Sbjct: 1456 ----PPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPP--------TTTPSPP 1503

Query: 806  SGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSK 865
            + +P  ++ PA++++      + P  +P PP       P ++ P      P   P   + 
Sbjct: 1504 TTTP--ITPPASTTT------LPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTT 1555

Query: 866  GGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPA 925
               PP      P  T +                P P   PS P            +  P+
Sbjct: 1556 L--PPTTTPSPPPTTTT---------------TPPPTTTPSPP-----------TTTTPS 1587

Query: 926  PSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLER 985
            P +                  +++  P  PP   P PP +  +T                
Sbjct: 1588 PPT------------------ITTTTP--PPTTTPSPPTTTTTT---------------- 1611

Query: 986  PVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPS-VGVPPPASPSYPRA 1044
                                     PP     SP    P+    S   +PP  +PS P  
Sbjct: 1612 -------------------------PPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPT 1646

Query: 1045 EPLTAPPT 1052
               T PPT
Sbjct: 1647 TTTTPPPT 1654



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 137/772 (17%), Positives = 240/772 (31%), Gaps = 87/772 (11%)

Query: 304  TFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAE-PLSPAMSISPQATYLSKLIPHAVLPP 362
            T  G  T T  P  T       P  TG   P   P++   +++P  T      P     P
Sbjct: 2073 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTP 2126

Query: 363  TVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSS 422
            T   +        T +     + +   + +    ++  +P P    P+ +    +   ++
Sbjct: 2127 TTTPITTTTTVTPTPTPTGTQTPTTTPITT----TTTVTPTPT---PTGTQTPTTTPITT 2179

Query: 423  DTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSG 482
             T V+   T +        P ++T + +  P P G     +    +T   + T +   + 
Sbjct: 2180 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2239

Query: 483  QLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGS 542
              +   ++      P P P  T +     +        + P P     P   + PTT   
Sbjct: 2240 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT---VTPTPT----PTGTQTPTTTPI 2292

Query: 543  EGAGAAPCPPNPANSWVPGLSPGGSRR---PPRSPERTLSPSSG--YSSQSGTPTLPPKG 597
                     P P  +  P  +P  +     P  +P  T +P++    ++ + TPT  P G
Sbjct: 2293 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2352

Query: 598  LAGPPASP---GKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPL 654
               P  +P        P P   T  ++P    ++ +T+  + +  P P+    P   TP+
Sbjct: 2353 TQTPTTTPITTTTTVTPTPTP-TGTQTP---TTTPITTTTTVTPTPTPTGTQTPTT-TPI 2407

Query: 655  GDRFVIPPHPKVPAPFSPPPSKPRS------PNPAAPALAAPAVVPGPVSTTDASPQSPP 708
                 + P P  P     P + P +      P P       P   P    TT  +    P
Sbjct: 2408 TTTTTVTPTP-TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP---ITTTTTVTPTP 2463

Query: 709  TPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPN 768
            TP  T TP       +   +P P+P  +  P   P      V   P+ + T         
Sbjct: 2464 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2523

Query: 769  WPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQ 828
                  P P           P      +  +P P  P+G+    ++P  ++++ T     
Sbjct: 2524 TTTTVTPTPTPTGTQTPTTTPITTT--TTVTPTPT-PTGTQTPTTTPITTTTTVTPTP-T 2579

Query: 829  PPGSPDPPPAP--------PAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVT 880
            P G+  P   P        P P P  +      + P   P+  +    P     G    T
Sbjct: 2580 PTGTQTPTTTPITTTTTVTPTPTPTGT------QTPTTTPITTTTTVTPTPTPTGTQ--T 2631

Query: 881  PSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACS 940
            P+   +    +V      PTP   P+  Q P    ++   +  P P+         +  +
Sbjct: 2632 PTTTPITTTTTV-----TPTPT--PTGTQTPTTTPITTTTTVTPTPT-----PTGTQTPT 2679

Query: 941  LAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLV 1000
                   ++  P   P     P  +P +T + +            P    T         
Sbjct: 2680 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV-----------TPTPTPTGTQTPTTTP 2728

Query: 1001 AELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPT 1052
                +     P     ++P   P          P P     P   P+T   T
Sbjct: 2729 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2780



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 137/772 (17%), Positives = 240/772 (31%), Gaps = 87/772 (11%)

Query: 304  TFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAE-PLSPAMSISPQATYLSKLIPHAVLPP 362
            T  G  T T  P  T       P  TG   P   P++   +++P  T      P     P
Sbjct: 2349 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTP 2402

Query: 363  TVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSS 422
            T   +        T +     + +   + +    ++  +P P    P+ +    +   ++
Sbjct: 2403 TTTPITTTTTVTPTPTPTGTQTPTTTPITT----TTTVTPTPT---PTGTQTPTTTPITT 2455

Query: 423  DTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSG 482
             T V+   T +        P ++T + +  P P G     +    +T   + T +   + 
Sbjct: 2456 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2515

Query: 483  QLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGS 542
              +   ++      P P P  T +     +        + P P     P   + PTT   
Sbjct: 2516 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT---VTPTPT----PTGTQTPTTTPI 2568

Query: 543  EGAGAAPCPPNPANSWVPGLSPGGSRR---PPRSPERTLSPSSG--YSSQSGTPTLPPKG 597
                     P P  +  P  +P  +     P  +P  T +P++    ++ + TPT  P G
Sbjct: 2569 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2628

Query: 598  LAGPPASP---GKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPL 654
               P  +P        P P   T  ++P    ++ +T+  + +  P P+    P   TP+
Sbjct: 2629 TQTPTTTPITTTTTVTPTPTP-TGTQTP---TTTPITTTTTVTPTPTPTGTQTPTT-TPI 2683

Query: 655  GDRFVIPPHPKVPAPFSPPPSKPRS------PNPAAPALAAPAVVPGPVSTTDASPQSPP 708
                 + P P  P     P + P +      P P       P   P    TT  +    P
Sbjct: 2684 TTTTTVTPTP-TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP---ITTTTTVTPTP 2739

Query: 709  TPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPN 768
            TP  T TP       +   +P P+P  +  P   P      V   P+ + T         
Sbjct: 2740 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2799

Query: 769  WPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQ 828
                  P P           P      +  +P P  P+G+    ++P  ++++ T     
Sbjct: 2800 TTTTVTPTPTPTGTQTPTTTPITTT--TTVTPTPT-PTGTQTPTTTPITTTTTVTPTP-T 2855

Query: 829  PPGSPDPPPAP--------PAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVT 880
            P G+  P   P        P P P  +      + P   P+  +    P     G    T
Sbjct: 2856 PTGTQTPTTTPITTTTTVTPTPTPTGT------QTPTTTPITTTTTVTPTPTPTGTQ--T 2907

Query: 881  PSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACS 940
            P+   +    +V      PTP   P+  Q P    ++   +  P P+         +  +
Sbjct: 2908 PTTTPITTTTTV-----TPTPT--PTGTQTPTTTPITTTTTVTPTPT-----PTGTQTPT 2955

Query: 941  LAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLV 1000
                   ++  P   P     P  +P +T + +            P    T         
Sbjct: 2956 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV-----------TPTPTPTGTQTPTTTP 3004

Query: 1001 AELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPT 1052
                +     P     ++P   P          P P     P   P+T   T
Sbjct: 3005 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3056



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 137/772 (17%), Positives = 240/772 (31%), Gaps = 87/772 (11%)

Query: 304  TFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAE-PLSPAMSISPQATYLSKLIPHAVLPP 362
            T  G  T T  P  T       P  TG   P   P++   +++P  T      P     P
Sbjct: 2625 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTP 2678

Query: 363  TVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSS 422
            T   +        T +     + +   + +    ++  +P P    P+ +    +   ++
Sbjct: 2679 TTTPITTTTTVTPTPTPTGTQTPTTTPITT----TTTVTPTPT---PTGTQTPTTTPITT 2731

Query: 423  DTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSG 482
             T V+   T +        P ++T + +  P P G     +    +T   + T +   + 
Sbjct: 2732 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2791

Query: 483  QLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGS 542
              +   ++      P P P  T +     +        + P P     P   + PTT   
Sbjct: 2792 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT---VTPTPT----PTGTQTPTTTPI 2844

Query: 543  EGAGAAPCPPNPANSWVPGLSPGGSRR---PPRSPERTLSPSSG--YSSQSGTPTLPPKG 597
                     P P  +  P  +P  +     P  +P  T +P++    ++ + TPT  P G
Sbjct: 2845 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2904

Query: 598  LAGPPASP---GKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPL 654
               P  +P        P P   T  ++P    ++ +T+  + +  P P+    P   TP+
Sbjct: 2905 TQTPTTTPITTTTTVTPTPTP-TGTQTP---TTTPITTTTTVTPTPTPTGTQTPTT-TPI 2959

Query: 655  GDRFVIPPHPKVPAPFSPPPSKPRS------PNPAAPALAAPAVVPGPVSTTDASPQSPP 708
                 + P P  P     P + P +      P P       P   P    TT  +    P
Sbjct: 2960 TTTTTVTPTP-TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP---ITTTTTVTPTP 3015

Query: 709  TPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPN 768
            TP  T TP       +   +P P+P  +  P   P      V   P+ + T         
Sbjct: 3016 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3075

Query: 769  WPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQ 828
                  P P           P      +  +P P  P+G+    ++P  ++++ T     
Sbjct: 3076 TTTTVTPTPTPTGTQTPTTTPITTT--TTVTPTPT-PTGTQTPTTTPITTTTTVTPTP-T 3131

Query: 829  PPGSPDPPPAP--------PAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVT 880
            P G+  P   P        P P P  +      + P   P+  +    P     G    T
Sbjct: 3132 PTGTQTPTTTPITTTTTVTPTPTPTGT------QTPTTTPITTTTTVTPTPTPTGTQ--T 3183

Query: 881  PSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACS 940
            P+   +    +V      PTP   P+  Q P    ++   +  P P+         +  +
Sbjct: 3184 PTTTPITTTTTV-----TPTPT--PTGTQTPTTTPITTTTTVTPTPT-----PTGTQTPT 3231

Query: 941  LAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLV 1000
                   ++  P   P     P  +P +T + +            P    T         
Sbjct: 3232 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV-----------TPTPTPTGTQTPTTTP 3280

Query: 1001 AELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPT 1052
                +     P     ++P   P          P P     P   P+T   T
Sbjct: 3281 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3332



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 137/772 (17%), Positives = 240/772 (31%), Gaps = 87/772 (11%)

Query: 304  TFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAE-PLSPAMSISPQATYLSKLIPHAVLPP 362
            T  G  T T  P  T       P  TG   P   P++   +++P  T      P     P
Sbjct: 2901 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTP 2954

Query: 363  TVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSS 422
            T   +        T +     + +   + +    ++  +P P    P+ +    +   ++
Sbjct: 2955 TTTPITTTTTVTPTPTPTGTQTPTTTPITT----TTTVTPTPT---PTGTQTPTTTPITT 3007

Query: 423  DTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSG 482
             T V+   T +        P ++T + +  P P G     +    +T   + T +   + 
Sbjct: 3008 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3067

Query: 483  QLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGS 542
              +   ++      P P P  T +     +        + P P     P   + PTT   
Sbjct: 3068 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT---VTPTPT----PTGTQTPTTTPI 3120

Query: 543  EGAGAAPCPPNPANSWVPGLSPGGSRR---PPRSPERTLSPSSG--YSSQSGTPTLPPKG 597
                     P P  +  P  +P  +     P  +P  T +P++    ++ + TPT  P G
Sbjct: 3121 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3180

Query: 598  LAGPPASP---GKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPL 654
               P  +P        P P   T  ++P    ++ +T+  + +  P P+    P   TP+
Sbjct: 3181 TQTPTTTPITTTTTVTPTPTP-TGTQTP---TTTPITTTTTVTPTPTPTGTQTPTT-TPI 3235

Query: 655  GDRFVIPPHPKVPAPFSPPPSKPRS------PNPAAPALAAPAVVPGPVSTTDASPQSPP 708
                 + P P  P     P + P +      P P       P   P    TT  +    P
Sbjct: 3236 TTTTTVTPTP-TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP---ITTTTTVTPTP 3291

Query: 709  TPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPN 768
            TP  T TP       +   +P P+P  +  P   P      V   P+ + T         
Sbjct: 3292 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3351

Query: 769  WPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQ 828
                  P P           P      +  +P P  P+G+    ++P  ++++ T     
Sbjct: 3352 TTTTVTPTPTPTGTQTPTTTPITTT--TTVTPTPT-PTGTQTPTTTPITTTTTVTPTP-T 3407

Query: 829  PPGSPDPPPAP--------PAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVT 880
            P G+  P   P        P P P  +      + P   P+  +    P     G    T
Sbjct: 3408 PTGTQTPTTTPITTTTTVTPTPTPTGT------QTPTTTPITTTTTVTPTPTPTGTQ--T 3459

Query: 881  PSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACS 940
            P+   +    +V      PTP   P+  Q P    ++   +  P P+         +  +
Sbjct: 3460 PTTTPITTTTTV-----TPTPT--PTGTQTPTTTPITTTTTVTPTPT-----PTGTQTPT 3507

Query: 941  LAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLV 1000
                   ++  P   P     P  +P +T + +            P    T         
Sbjct: 3508 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV-----------TPTPTPTGTQTPTTTP 3556

Query: 1001 AELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPT 1052
                +     P     ++P   P          P P     P   P+T   T
Sbjct: 3557 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3608



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 137/772 (17%), Positives = 240/772 (31%), Gaps = 87/772 (11%)

Query: 304  TFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAE-PLSPAMSISPQATYLSKLIPHAVLPP 362
            T  G  T T  P  T       P  TG   P   P++   +++P  T      P     P
Sbjct: 3177 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT------PTGTQTP 3230

Query: 363  TVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSS 422
            T   +        T +     + +   + +    ++  +P P    P+ +    +   ++
Sbjct: 3231 TTTPITTTTTVTPTPTPTGTQTPTTTPITT----TTTVTPTPT---PTGTQTPTTTPITT 3283

Query: 423  DTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSG 482
             T V+   T +        P ++T + +  P P G     +    +T   + T +   + 
Sbjct: 3284 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3343

Query: 483  QLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGS 542
              +   ++      P P P  T +     +        + P P     P   + PTT   
Sbjct: 3344 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT---VTPTPT----PTGTQTPTTTPI 3396

Query: 543  EGAGAAPCPPNPANSWVPGLSPGGSRR---PPRSPERTLSPSSG--YSSQSGTPTLPPKG 597
                     P P  +  P  +P  +     P  +P  T +P++    ++ + TPT  P G
Sbjct: 3397 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3456

Query: 598  LAGPPASP---GKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPL 654
               P  +P        P P   T  ++P    ++ +T+  + +  P P+    P   TP+
Sbjct: 3457 TQTPTTTPITTTTTVTPTPTP-TGTQTP---TTTPITTTTTVTPTPTPTGTQTPTT-TPI 3511

Query: 655  GDRFVIPPHPKVPAPFSPPPSKPRS------PNPAAPALAAPAVVPGPVSTTDASPQSPP 708
                 + P P  P     P + P +      P P       P   P    TT  +    P
Sbjct: 3512 TTTTTVTPTP-TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP---ITTTTTVTPTP 3567

Query: 709  TPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPN 768
            TP  T TP       +   +P P+P  +  P   P      V   P+ + T         
Sbjct: 3568 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3627

Query: 769  WPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQ 828
                  P P           P      +  +P P  P+G+    ++P  ++++ T     
Sbjct: 3628 TTTTVTPTPTPTGTQTPTTTPITTT--TTVTPTPT-PTGTQTPTTTPITTTTTVTPTP-T 3683

Query: 829  PPGSPDPPPAP--------PAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVT 880
            P G+  P   P        P P P  +      + P   P+  +    P     G    T
Sbjct: 3684 PTGTQTPTTTPITTTTTVTPTPTPTGT------QTPTTTPITTTTTVTPTPTPTGTQ--T 3735

Query: 881  PSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACS 940
            P+   +    +V      PTP   P+  Q P    ++   +  P P+         +  +
Sbjct: 3736 PTTTPITTTTTV-----TPTPT--PTGTQTPTTTPITTTTTVTPTPT-----PTGTQTPT 3783

Query: 941  LAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLV 1000
                   ++  P   P     P  +P +T + +            P    T         
Sbjct: 3784 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV-----------TPTPTPTGTQTPTTTP 3832

Query: 1001 AELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPT 1052
                +     P     ++P   P          P P     P   P+T   T
Sbjct: 3833 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3884



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 99/533 (18%), Positives = 164/533 (30%), Gaps = 71/533 (13%)

Query: 537  PTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPK 596
            PT  G++     P       +  P  +P G++ P  +P  T +        + TPT  P 
Sbjct: 2026 PTPTGTQTPTTTPI--TTTTTVTPTPTPTGTQTPTTTPITTTT--------TVTPTPTPT 2075

Query: 597  GLAGPPASP---GKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTP 653
            G   P  +P        P P   T  ++P    ++ +T+  + +  P P+    P   TP
Sbjct: 2076 GTQTPTTTPITTTTTVTPTPTP-TGTQTP---TTTPITTTTTVTPTPTPTGTQTPTT-TP 2130

Query: 654  LGDRFVIPPHPKVPAPFSPPPSKPRS------PNPAAPALAAPAVVPGPVSTTDASPQSP 707
            +     + P P  P     P + P +      P P       P   P    TT  +    
Sbjct: 2131 ITTTTTVTPTP-TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP---ITTTTTVTPT 2186

Query: 708  PTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDP 767
            PTP  T TP       +   +P P+P  +  P   P      V   P+ + T        
Sbjct: 2187 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2246

Query: 768  NWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQI 827
                   P P           P      +  +P P  P+G+    ++P  ++++ T    
Sbjct: 2247 TTTTTVTPTPTPTGTQTPTTTPITTT--TTVTPTPT-PTGTQTPTTTPITTTTTVTPTP- 2302

Query: 828  QPPGSPDPPPAP--------PAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLV 879
             P G+  P   P        P P P  +      + P   P+  +    P     G    
Sbjct: 2303 TPTGTQTPTTTPITTTTTVTPTPTPTGT------QTPTTTPITTTTTVTPTPTPTGTQ-- 2354

Query: 880  TPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKAC 939
            TP+   +    +V      PTP   P+  Q P    ++   +  P P+         +  
Sbjct: 2355 TPTTTPITTTTTV-----TPTPT--PTGTQTPTTTPITTTTTVTPTPT-----PTGTQTP 2402

Query: 940  SLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNL 999
            +       ++  P   P     P  +P +T + +            P    T        
Sbjct: 2403 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV-----------TPTPTPTGTQTPTTT 2451

Query: 1000 VAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPT 1052
                 +     P     ++P   P          P P     P   P+T   T
Sbjct: 2452 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2504



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 144/791 (18%), Positives = 236/791 (29%), Gaps = 98/791 (12%)

Query: 309  STGTRAPPLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVA 368
            +T T  PP T P       +T  A     L P  + SP  T  +   P     P      
Sbjct: 1489 TTTTTPPPTTTPSPPTTTPITPPASTTT-LPPTTTPSPPTTTTTTPPPTTTPSPPTTTPI 1547

Query: 369  LGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTW-------SHSQS 421
                S  TL   +  S  P +  +    ++ S P   +  P + + T        S   +
Sbjct: 1548 TPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTT 1607

Query: 422  SDTIVSDGSTLSSKGGSEGQPESSTAS------------NSVVPPPQGGSGRGSPSGGST 469
            + T     +T S    +   P +ST +             +  PPP       +PS  +T
Sbjct: 1608 TTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTT-----TPSPPTT 1662

Query: 470  AEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQ 529
               S  ++  ++   +    S   +   P PP  T +        P  P+     P    
Sbjct: 1663 TTPSPPITTTTTPPPTTTPSS--PITTTPSPPTTTMTTPSP-TTTPSSPITTTTTPSSTT 1719

Query: 530  QPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGG----SRRPPRSPERTLSPSSGYS 585
             P    PPTT  +      P PP    + +P  +       +  PP     T SP S  +
Sbjct: 1720 TPS--PPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFS--T 1775

Query: 586  SQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDP-APSD 644
            +   TP +P     G   S GK    KP   T L         +    C ++  P  P  
Sbjct: 1776 TTPTTPCVPLCNWTGWLDS-GKPNFHKPGGDTELIGDVCGPGWAANISCRATMYPDVPIG 1834

Query: 645  RSGPQILTPLGDRFVIPPHPKVPAPFSPPP---------------SKPRSPNPAAPALAA 689
            + G  ++  +    +     + P    P                 ++P +          
Sbjct: 1835 QLGQTVVCDVSVGLICKNEDQKPGGVIPMAFCLNYEINVQCCECVTQPTTMTTTTTENPT 1894

Query: 690  PAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEV 749
            P       +TT  +P   PTP  T TP       +   +P P+P  +  P   P      
Sbjct: 1895 PPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 1952

Query: 750  VVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSP 809
            V   P+ + T               P P           P      +  +P P  P+G+ 
Sbjct: 1953 VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT--TTVTPTPT-PTGTQ 2009

Query: 810  ELVSSPAASSSSATALQIQPPGSPDPPPAP--------PAPAPASSAPGHVAKLPQKEPV 861
               ++P  ++++ T     P G+  P   P        P P P  +      + P   P+
Sbjct: 2010 TPTTTPITTTTTVTPTP-TPTGTQTPTTTPITTTTTVTPTPTPTGT------QTPTTTPI 2062

Query: 862  GCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRAS 921
              +    P     G    TP+   +    +V      PTP   P+  Q P    ++   +
Sbjct: 2063 TTTTTVTPTPTPTGTQ--TPTTTPITTTTTV-----TPTPT--PTGTQTPTTTPITTTTT 2113

Query: 922  PVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKL 981
              P P+         +  +       ++  P   P     P  +P +T + +        
Sbjct: 2114 VTPTPT-----PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV-------- 2160

Query: 982  QLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSY 1041
                P    T             +     P     ++P   P          P P     
Sbjct: 2161 ---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2217

Query: 1042 PRAEPLTAPPT 1052
            P   P+T   T
Sbjct: 2218 PTTTPITTTTT 2228



 Score = 37.4 bits (85), Expect = 0.078
 Identities = 45/222 (20%), Positives = 65/222 (29%), Gaps = 45/222 (20%)

Query: 832  SPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRS 891
            +P PP   P+P P S+        P   P   +    PP      P+ T +         
Sbjct: 1398 TPSPPTTTPSPPPTSTTTLPPTTTPS--PPTTTTTTPPPTTTPSPPITTTT--------- 1446

Query: 892  VGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQ 951
                   P P   PS P       +S   +P P  +            +  +    ++  
Sbjct: 1447 ------TPPPTTTPSPP-------ISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTT 1493

Query: 952  PNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRP 1011
            P  PP   P PP +   T                   P +   L         + +   P
Sbjct: 1494 P--PPTTTPSPPTTTPITP------------------PASTTTLPPTTTPSPPTTTTTTP 1533

Query: 1012 PQAPKKSPKAPPPVARKPS-VGVPPPASPSYPRAEPLTAPPT 1052
            P     SP    P+    S   +PP  +PS P     T PPT
Sbjct: 1534 PPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPT 1575



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 31/148 (20%), Positives = 50/148 (33%), Gaps = 8/148 (5%)

Query: 911  PLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQS----- 965
            P+ + ++  + P   PS    +   L   +  +    ++  P  PP   P PP +     
Sbjct: 1391 PMDKCITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTP--PPTTTPSPPITTTTTP 1448

Query: 966  -PASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPP 1024
             P +T S   S  +       P  P T         +   + +   PP      P   P 
Sbjct: 1449 PPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPI 1508

Query: 1025 VARKPSVGVPPPASPSYPRAEPLTAPPT 1052
                 +  +PP  +PS P     T PPT
Sbjct: 1509 TPPASTTTLPPTTTPSPPTTTTTTPPPT 1536


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score =  104 bits (259), Expect = 5e-22
 Identities = 140/633 (22%), Positives = 222/633 (35%), Gaps = 70/633 (11%)

Query: 453  PPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPP-PRRTHSLHQRG 511
            PP    +G G  +G       DT + + +   +   ++  K   P P  P  + +  +  
Sbjct: 82   PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETS 141

Query: 512  LAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGS--RR 569
            L V           E K+     +  +T G E   +A    +   +    L+P      +
Sbjct: 142  LTV-----NKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 196

Query: 570  PPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSS 629
            P    E T    +  + +  TPT P +     PAS    +P      ++  +P     ++
Sbjct: 197  PTPKAETTTKGPALTTPKEPTPTTPKE-----PASTTPKEPTPTTIKSAPTTPKEPAPTT 251

Query: 630  LTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPP--PSKPRSPNPAAPAL 687
              S  ++  +PAP+    P   TP   +   P   K PAP +    P+ P+ P P  P  
Sbjct: 252  TKSAPTTPKEPAPTTTKEPAPTTP---KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKK 308

Query: 688  AAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKP 747
             AP     P  TT   P +P TP+    P  + P  +  + P P+ P    P P   K+P
Sbjct: 309  PAPTTPKEPAPTTPKEP-TPTTPKEP-APTTKEPAPTTPKEPAPTAPKK--PAPTTPKEP 364

Query: 748  EVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSG 807
                    A  T +EP   P  P  P P   +   +    P P     +  +P+   P+ 
Sbjct: 365  APTTPKEPAPTTTKEP--SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT 422

Query: 808  SPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPA-PASSAPGHVAKLPQKEPVGCSKG 866
            + E   +P      A     +P  +    PAP  P  PA +     A    KEP   +  
Sbjct: 423  TKE--PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK 480

Query: 867  GGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAP 926
               P        +TP+  + +   +   P       L P+ P++P     +      PAP
Sbjct: 481  ETAPTTP---KKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP-----TPTTPEEPAP 532

Query: 927  SSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTA----SFIFSKGSRKLQ 982
            ++             AA        P  P E  P  P+ PA T     +    KG+    
Sbjct: 533  TTP----------KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTT 582

Query: 983  LERPV--SPETQA--DLQRNLVAELRSISEQRP---------PQAPKK----SPKAPPPV 1025
            L+ P   +P+  A  +L      E  S +  +P         P  PK+    +PK P P 
Sbjct: 583  LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 642

Query: 1026 ARKPSVGV----PPPASPSYPRAEPLTAPPTNG 1054
              K +       P P +P  P  + L    T G
Sbjct: 643  TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKG 675



 Score =  102 bits (253), Expect = 3e-21
 Identities = 153/726 (21%), Positives = 239/726 (32%), Gaps = 82/726 (11%)

Query: 403  QPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRG 462
            +P S  P   + T   S  +       +T  S   +  +P  +T        P+  +   
Sbjct: 223  EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 282

Query: 463  SPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPP--PPRRTHSLHQRGLAVPDGPLG 520
            +     T   S   + +     + +  +    K P P  P   T +  +        P  
Sbjct: 283  TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP 342

Query: 521  LPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSP 580
              PK      P+ P P T    E A   P  P P  +  P      S   P+ P  T + 
Sbjct: 343  TTPKEPAPTAPKKPAPTTP--KEPAPTTPKEPAPTTTKEP------SPTTPKEPAPTTTK 394

Query: 581  SSGYSSQSGTPTLPPKGLAGPPA-SPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSD 639
            S+  +++   PT        P   SP   + P P   T+ + P  +         ++  +
Sbjct: 395  SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP---TTPKEPAPTTPKKPAP--TTPKE 449

Query: 640  PAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPN---PAAPALAAPAVVPGP 696
            PAP+    P    P   +   P  PK PAP +P  + P +P    P  P   AP     P
Sbjct: 450  PAPTTPKEP---APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP 506

Query: 697  VSTT--DASPQSP--PTPQTT-----LTPLQESPVISKDQSP--PPSPPPSYHPPPPPTK 745
              TT  + +P +P  PTP T       TP   +P   K+ +P  P  P P+    P PT 
Sbjct: 507  APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT 566

Query: 746  KPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFP----------------- 788
              E     P    TA   L++P    P  PAP+E   +    P                 
Sbjct: 567  PKETAPTTPKG--TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 624

Query: 789  ---PPEEAFFSVASPEPAGPSGS-PELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAP 844
               P E A  +   P P  P G+ P  +  PA ++    A +   P +   P +  +  P
Sbjct: 625  PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 684

Query: 845  ASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALG 904
            A + P   A    KEP   +     P      P  T  +      +       +P  +  
Sbjct: 685  APTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST- 743

Query: 905  PSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQ 964
            P    +P  +AL         P++   AA + +  +  A +  +       PE     P+
Sbjct: 744  PELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTT-TAKDKTTERDLRTTPETTTAAPK 802

Query: 965  SPASTASFIFSKGSRKLQLERP-VSPETQADLQRNLVAELRSIS---------------- 1007
                TA+        K+      V+  T  D     +  L++ +                
Sbjct: 803  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 862

Query: 1008 ------EQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEP-LTAPPTNGLPHTQD 1060
                  E   P+    + KA  P  +KP+     P S   P+  P +  P T   P    
Sbjct: 863  IMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMT 922

Query: 1061 RTKREL 1066
             T  EL
Sbjct: 923  STMPEL 928



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 108/479 (22%), Positives = 171/479 (35%), Gaps = 59/479 (12%)

Query: 400 SSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQ--G 457
           ++ +P    P   + T + S  + T     +T  S   +  +P  +T        P+   
Sbjct: 376 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 435

Query: 458 GSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDG 517
            +    P+  +  E + T     +   + +       +  P  P+ T          P  
Sbjct: 436 PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKET---------APTT 486

Query: 518 PLGLPPKPERKQQPQLP-RPPTTGGSEGAGAAPCPPNPANSWVPG------LSPGGSRRP 570
           P  L P    K  P  P +P  T   E A   P  P P     P        +P   + P
Sbjct: 487 PKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEP 546

Query: 571 ----PRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASV 626
               P+ P  T       ++   T    PKG A  P +  +  P  P++         + 
Sbjct: 547 APTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA--PTTLKEPAPTTPKKPAPKELAPTTT 604

Query: 627 SSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRS------- 679
               ++ C     PAP+   G    TP   +   P  PK PAP +P  + P +       
Sbjct: 605 KEPTSTTCDK---PAPTTPKGTAPTTP---KEPAPTTPKEPAPTTPKGTAPTTLKEPAPT 658

Query: 680 -PNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTT--LTPLQESPVISKDQSP--PPSPP 734
            P   AP   AP    GP STT   P +P TP+ T   TP + +P   K  +P  P +PP
Sbjct: 659 TPKKPAPKELAPTTTKGPTSTTSDKP-APTTPKETAPTTPKEPAPTTPKKPAPTTPETPP 717

Query: 735 P--SYHPPPPPTKKPEVVVEAP--SASETAEEPL--------QDPNWPPPPPPAPEEQDL 782
           P  S    P  TK+P  + ++P  S  E + EP         ++P  P    PA  + ++
Sbjct: 718 PTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEM 777

Query: 783 -SMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSS---ATALQIQPPGSPDPPP 837
            + A     E    +      A P  + E  ++   ++ S   AT  Q+    + D  P
Sbjct: 778 TTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 836



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 75/348 (21%), Positives = 107/348 (30%), Gaps = 65/348 (18%)

Query: 743  PTKKPEVVVEAPSASETAEEPLQDPNWPP-------------------PPPPAPEEQDLS 783
            PT KP VV EA S  +  +  +  P+                      P P  P   D S
Sbjct: 78   PTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTS 137

Query: 784  -----MADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGS-----P 833
                   +     E   +  + +     G  +  S+    S   T+ +   P S     P
Sbjct: 138  KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 197

Query: 834  DPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVG 893
             P        PA + P        KEP   +     P+E       TP+      ++S  
Sbjct: 198  TPKAETTTKGPALTTPKEPTPTTPKEPASTT-----PKEP------TPT-----TIKSAP 241

Query: 894  APGGAPTPALGPSAPQKPLRRALSGRASPVP-APSSGLHAAVRLKACSLAASEGLSSAQP 952
                 P P    SAP  P   A +    P P  P        +  A +   S       P
Sbjct: 242  TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS------AP 295

Query: 953  NGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPP 1012
              P E  P  P+ PA T      K       + P +P T  +          +  ++  P
Sbjct: 296  TTPKEPAPTTPKKPAPTT----PKEPAPTTPKEP-TPTTPKEPAPTTKEPAPTTPKEPAP 350

Query: 1013 QAPKK----SPKAPPPVARK----PSVGVPPPASPSYPRAEPLTAPPT 1052
             APKK    +PK P P   K     +   P P +P  P      + PT
Sbjct: 351  TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 398


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score =  104 bits (259), Expect = 5e-22
 Identities = 140/633 (22%), Positives = 222/633 (35%), Gaps = 70/633 (11%)

Query: 453  PPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPP-PRRTHSLHQRG 511
            PP    +G G  +G       DT + + +   +   ++  K   P P  P  + +  +  
Sbjct: 123  PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETS 182

Query: 512  LAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGS--RR 569
            L V           E K+     +  +T G E   +A    +   +    L+P      +
Sbjct: 183  LTV-----NKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 237

Query: 570  PPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSS 629
            P    E T    +  + +  TPT P +     PAS    +P      ++  +P     ++
Sbjct: 238  PTPKAETTTKGPALTTPKEPTPTTPKE-----PASTTPKEPTPTTIKSAPTTPKEPAPTT 292

Query: 630  LTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPP--PSKPRSPNPAAPAL 687
              S  ++  +PAP+    P   TP   +   P   K PAP +    P+ P+ P P  P  
Sbjct: 293  TKSAPTTPKEPAPTTTKEPAPTTP---KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKK 349

Query: 688  AAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKP 747
             AP     P  TT   P +P TP+    P  + P  +  + P P+ P    P P   K+P
Sbjct: 350  PAPTTPKEPAPTTPKEP-TPTTPKEP-APTTKEPAPTTPKEPAPTAPKK--PAPTTPKEP 405

Query: 748  EVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSG 807
                    A  T +EP   P  P  P P   +   +    P P     +  +P+   P+ 
Sbjct: 406  APTTPKEPAPTTTKEP--SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT 463

Query: 808  SPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPA-PASSAPGHVAKLPQKEPVGCSKG 866
            + E   +P      A     +P  +    PAP  P  PA +     A    KEP   +  
Sbjct: 464  TKE--PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK 521

Query: 867  GGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAP 926
               P        +TP+  + +   +   P       L P+ P++P     +      PAP
Sbjct: 522  ETAPTTP---KKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP-----TPTTPEEPAP 573

Query: 927  SSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTA----SFIFSKGSRKLQ 982
            ++             AA        P  P E  P  P+ PA T     +    KG+    
Sbjct: 574  TTP----------KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTT 623

Query: 983  LERPV--SPETQA--DLQRNLVAELRSISEQRP---------PQAPKK----SPKAPPPV 1025
            L+ P   +P+  A  +L      E  S +  +P         P  PK+    +PK P P 
Sbjct: 624  LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 683

Query: 1026 ARKPSVGV----PPPASPSYPRAEPLTAPPTNG 1054
              K +       P P +P  P  + L    T G
Sbjct: 684  TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKG 716



 Score =  102 bits (253), Expect = 3e-21
 Identities = 153/726 (21%), Positives = 239/726 (32%), Gaps = 82/726 (11%)

Query: 403  QPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRG 462
            +P S  P   + T   S  +       +T  S   +  +P  +T        P+  +   
Sbjct: 264  EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 323

Query: 463  SPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPP--PPRRTHSLHQRGLAVPDGPLG 520
            +     T   S   + +     + +  +    K P P  P   T +  +        P  
Sbjct: 324  TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP 383

Query: 521  LPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSP 580
              PK      P+ P P T    E A   P  P P  +  P      S   P+ P  T + 
Sbjct: 384  TTPKEPAPTAPKKPAPTTP--KEPAPTTPKEPAPTTTKEP------SPTTPKEPAPTTTK 435

Query: 581  SSGYSSQSGTPTLPPKGLAGPPA-SPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSD 639
            S+  +++   PT        P   SP   + P P   T+ + P  +         ++  +
Sbjct: 436  SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP---TTPKEPAPTTPKKPAP--TTPKE 490

Query: 640  PAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPN---PAAPALAAPAVVPGP 696
            PAP+    P    P   +   P  PK PAP +P  + P +P    P  P   AP     P
Sbjct: 491  PAPTTPKEP---APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP 547

Query: 697  VSTT--DASPQSP--PTPQTT-----LTPLQESPVISKDQSP--PPSPPPSYHPPPPPTK 745
              TT  + +P +P  PTP T       TP   +P   K+ +P  P  P P+    P PT 
Sbjct: 548  APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT 607

Query: 746  KPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFP----------------- 788
              E     P    TA   L++P    P  PAP+E   +    P                 
Sbjct: 608  PKETAPTTPKG--TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 665

Query: 789  ---PPEEAFFSVASPEPAGPSGS-PELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAP 844
               P E A  +   P P  P G+ P  +  PA ++    A +   P +   P +  +  P
Sbjct: 666  PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 725

Query: 845  ASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALG 904
            A + P   A    KEP   +     P      P  T  +      +       +P  +  
Sbjct: 726  APTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST- 784

Query: 905  PSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQ 964
            P    +P  +AL         P++   AA + +  +  A +  +       PE     P+
Sbjct: 785  PELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTT-TAKDKTTERDLRTTPETTTAAPK 843

Query: 965  SPASTASFIFSKGSRKLQLERP-VSPETQADLQRNLVAELRSIS---------------- 1007
                TA+        K+      V+  T  D     +  L++ +                
Sbjct: 844  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 903

Query: 1008 ------EQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEP-LTAPPTNGLPHTQD 1060
                  E   P+    + KA  P  +KP+     P S   P+  P +  P T   P    
Sbjct: 904  IMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMT 963

Query: 1061 RTKREL 1066
             T  EL
Sbjct: 964  STMPEL 969



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 108/479 (22%), Positives = 171/479 (35%), Gaps = 59/479 (12%)

Query: 400 SSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQ--G 457
           ++ +P    P   + T + S  + T     +T  S   +  +P  +T        P+   
Sbjct: 417 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 476

Query: 458 GSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDG 517
            +    P+  +  E + T     +   + +       +  P  P+ T          P  
Sbjct: 477 PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKET---------APTT 527

Query: 518 PLGLPPKPERKQQPQLP-RPPTTGGSEGAGAAPCPPNPANSWVPG------LSPGGSRRP 570
           P  L P    K  P  P +P  T   E A   P  P P     P        +P   + P
Sbjct: 528 PKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEP 587

Query: 571 ----PRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASV 626
               P+ P  T       ++   T    PKG A  P +  +  P  P++         + 
Sbjct: 588 APTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA--PTTLKEPAPTTPKKPAPKELAPTTT 645

Query: 627 SSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRS------- 679
               ++ C     PAP+   G    TP   +   P  PK PAP +P  + P +       
Sbjct: 646 KEPTSTTCDK---PAPTTPKGTAPTTP---KEPAPTTPKEPAPTTPKGTAPTTLKEPAPT 699

Query: 680 -PNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTT--LTPLQESPVISKDQSP--PPSPP 734
            P   AP   AP    GP STT   P +P TP+ T   TP + +P   K  +P  P +PP
Sbjct: 700 TPKKPAPKELAPTTTKGPTSTTSDKP-APTTPKETAPTTPKEPAPTTPKKPAPTTPETPP 758

Query: 735 P--SYHPPPPPTKKPEVVVEAP--SASETAEEPL--------QDPNWPPPPPPAPEEQDL 782
           P  S    P  TK+P  + ++P  S  E + EP         ++P  P    PA  + ++
Sbjct: 759 PTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEM 818

Query: 783 -SMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSS---ATALQIQPPGSPDPPP 837
            + A     E    +      A P  + E  ++   ++ S   AT  Q+    + D  P
Sbjct: 819 TTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 877



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 75/348 (21%), Positives = 107/348 (30%), Gaps = 65/348 (18%)

Query: 743  PTKKPEVVVEAPSASETAEEPLQDPNWPP-------------------PPPPAPEEQDLS 783
            PT KP VV EA S  +  +  +  P+                      P P  P   D S
Sbjct: 119  PTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTS 178

Query: 784  -----MADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGS-----P 833
                   +     E   +  + +     G  +  S+    S   T+ +   P S     P
Sbjct: 179  KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 238

Query: 834  DPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVG 893
             P        PA + P        KEP   +     P+E       TP+      ++S  
Sbjct: 239  TPKAETTTKGPALTTPKEPTPTTPKEPASTT-----PKEP------TPT-----TIKSAP 282

Query: 894  APGGAPTPALGPSAPQKPLRRALSGRASPVP-APSSGLHAAVRLKACSLAASEGLSSAQP 952
                 P P    SAP  P   A +    P P  P        +  A +   S       P
Sbjct: 283  TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS------AP 336

Query: 953  NGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPP 1012
              P E  P  P+ PA T      K       + P +P T  +          +  ++  P
Sbjct: 337  TTPKEPAPTTPKKPAPTT----PKEPAPTTPKEP-TPTTPKEPAPTTKEPAPTTPKEPAP 391

Query: 1013 QAPKK----SPKAPPPVARK----PSVGVPPPASPSYPRAEPLTAPPT 1052
             APKK    +PK P P   K     +   P P +P  P      + PT
Sbjct: 392  TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 439


>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
           preproprotein [Homo sapiens]
          Length = 331

 Score =  101 bits (251), Expect = 4e-21
 Identities = 101/372 (27%), Positives = 127/372 (34%), Gaps = 102/372 (27%)

Query: 493 KLKRPPPPPRRTHSLHQRGLAVPDGP------LGLPPKPERKQQPQLPR-----PPTTGG 541
           K + PPPPP +      +G   P GP       G PP+ ++ + P+ P      PP  GG
Sbjct: 46  KPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGG 105

Query: 542 SEGAGAAPCPPNPANSWVPGLSPGGSRRP--PRSPERTLSPSSGYSSQSGTPTLPPKG-- 597
           ++  G  P P  P      G  P G  RP  P  P +   P             PP+G  
Sbjct: 106 NQPQGPPPPPGKPQ-----GPPPQGGNRPQGPPPPGKPQGP-------------PPQGDK 147

Query: 598 LAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDR 657
              P + PGK Q P P+     + P                 P P    GP         
Sbjct: 148 SRSPRSPPGKPQGPPPQGGNQPQGP----------------PPPPGKPQGP--------- 182

Query: 658 FVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPL 717
              PP         PPP KP+ P P      +    PG        PQ PP PQ    P 
Sbjct: 183 ---PPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPG-------KPQGPP-PQGGNQPQ 231

Query: 718 QESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAP 777
              P   K Q PPP        PPPP K      +  S S++A         PP  P  P
Sbjct: 232 GPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARS-------PPGKPQGP 284

Query: 778 EEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPP 837
            +Q+ +    PPP           PAG  G+P+   +P             P G P  PP
Sbjct: 285 PQQEGNNPQGPPP-----------PAG--GNPQQPQAP-------------PAGQPQGPP 318

Query: 838 APPAPAPASSAP 849
            PP     S  P
Sbjct: 319 RPPQGGRPSRPP 330



 Score =  100 bits (248), Expect = 1e-20
 Identities = 95/312 (30%), Positives = 109/312 (34%), Gaps = 43/312 (13%)

Query: 579 SPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSS 638
           SP  G   Q G P  P K    PP    K Q P P        P    S S  S      
Sbjct: 40  SPQGGNKPQ-GPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQ 98

Query: 639 DPAPSDRSGPQILTPLGDRFVIPP-----HPKVPAPFSPPPSKPRSPNPAAPALAAPAVV 693
            P P   + PQ   P   +   PP      P+ P    PPP KP+ P P      +P   
Sbjct: 99  GPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQGP----PPPGKPQGPPPQGDKSRSPRSP 154

Query: 694 PGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEA 753
           PG        PQ PP PQ    P    P   K Q PPP        PPPP  KP+     
Sbjct: 155 PG-------KPQGPP-PQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPP-GKPQGPPPQ 205

Query: 754 PSASETAEEPLQDPNWPPP--------PPPAPEEQDLSMADFPPPEEAFFSVASPEPAGP 805
              S +++ P   P  PPP        PPP P          PPP+        P P  P
Sbjct: 206 GDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPP-----GKPQGPPPQGGNKPQGPPPPGKP 260

Query: 806 SGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAP--GHVAKLPQKEPVGC 863
            G P    S + S+ S       PPG P  PP      P    P  G   + PQ  P G 
Sbjct: 261 QGPPAQGGSKSQSARS-------PPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAG- 312

Query: 864 SKGGGPPREDVG 875
            +  GPPR   G
Sbjct: 313 -QPQGPPRPPQG 323



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 95/353 (26%), Positives = 118/353 (33%), Gaps = 67/353 (18%)

Query: 625 SVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPP-SKPRSPNPA 683
           S   S + +  +   P+P   + PQ   P   +   PP      P  PPP  KP+ P P 
Sbjct: 24  SQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQ 83

Query: 684 APALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPS--------PPP 735
                +P   PG        PQ PP PQ    P    P   K Q PPP         PPP
Sbjct: 84  GDKSRSPRSPPG-------KPQGPP-PQGGNQPQGPPPPPGKPQGPPPQGGNRPQGPPPP 135

Query: 736 SYHPPPPPTKKPEVVVEAPSASETAEEPL--QDPNWPPPPPPAPEEQDLSMADFPPPEEA 793
                PPP         +P        P     P  PPPPP  P+         PPP+  
Sbjct: 136 GKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQG--------PPPQGG 187

Query: 794 FFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVA 853
                 P P  P G P       +S S     Q  PP   + P  PP P      P    
Sbjct: 188 KKPQGPPPPGKPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGP---- 243

Query: 854 KLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPAL--GPSAPQKP 911
                 P G +K  GPP    G P   P            A GG+ + +    P  PQ P
Sbjct: 244 -----PPQGGNKPQGPP--PPGKPQGPP------------AQGGSKSQSARSPPGKPQGP 284

Query: 912 LRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQ 964
            ++  +    P P P+ G              +     A P G P+  PRPPQ
Sbjct: 285 PQQEGNNPQGP-PPPAGG--------------NPQQPQAPPAGQPQGPPRPPQ 322



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 106/396 (26%), Positives = 128/396 (32%), Gaps = 98/396 (24%)

Query: 637  SSDPAPSDRSG-PQILTPLGDRFVIPPHPKVPAPFSPPP---SKPRSPNPAAPALAAPAV 692
            S + +PS  +G PQ  +P G      P P    P  PPP   +KP+ P P       P  
Sbjct: 24   SQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPP-- 81

Query: 693  VPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVE 752
               P      SP+SPP                K Q PPP        PPPP  KP+    
Sbjct: 82   ---PQGDKSRSPRSPP---------------GKPQGPPPQGGNQPQGPPPPPGKPQ---- 119

Query: 753  APSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELV 812
                      P Q  N P  PPP  + Q       PPP+       S  P  P G P+  
Sbjct: 120  --------GPPPQGGNRPQGPPPPGKPQG------PPPQ----GDKSRSPRSPPGKPQ-- 159

Query: 813  SSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPRE 872
              P     +      QP G P PP  P  P P         K PQ  P      G PP+ 
Sbjct: 160  -GPPPQGGN------QPQGPPPPPGKPQGPPPQGG------KKPQGPPPPGKPQGPPPQG 206

Query: 873  DVGAPLVTPSLLQMVRLRSVGAPGGAPT-----PALGPSAPQKPLRRALSGRASPVPAPS 927
            D      +P           G P G P      P   P  P KP      G   P   P 
Sbjct: 207  DKSRSSQSPP----------GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPP 256

Query: 928  SGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPV 987
             G       +  S + S      +P GPP+ E   PQ P   A      G    Q + P 
Sbjct: 257  PGKPQGPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPA------GGNPQQPQAPP 310

Query: 988  SPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPP 1023
            + + Q                 RPPQ  +  P  PP
Sbjct: 311  AGQPQ--------------GPPRPPQGGR--PSRPP 330



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 93/375 (24%), Positives = 112/375 (29%), Gaps = 104/375 (27%)

Query: 703  SPQSPPTPQTTLTPLQESPVISKDQSPPPS--------PPPSYHPPPPPTKKPEVVVEAP 754
            +PQ P +PQ    P    P   K Q PPP         PPP     PPP         +P
Sbjct: 35   NPQGP-SPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSP 93

Query: 755  SASETAEEPL--QDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELV 812
                    P     P  PPPPP  P+         PPP+        P P  P G P   
Sbjct: 94   PGKPQGPPPQGGNQPQGPPPPPGKPQG--------PPPQGGNRPQGPPPPGKPQGPPPQG 145

Query: 813  SSPAASSSSATALQIQPP-GSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPR 871
                +  S     Q  PP G   P   PP P      P    K PQ  P      G PP+
Sbjct: 146  DKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQGPPPQ 205

Query: 872  EDVGAPLVTPSLLQMVRLRSVGAPGGAPT--PALGPSAPQKPLRRALSGRASPVPAPSSG 929
             D              + RS  +P G P   P  G + PQ            P P P   
Sbjct: 206  GD--------------KSRSSQSPPGKPQGPPPQGGNQPQ-----------GPPPPPG-- 238

Query: 930  LHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSP 989
                                 +P GPP      PQ P                  +P  P
Sbjct: 239  ---------------------KPQGPPPQGGNKPQGPPPPG--------------KPQGP 263

Query: 990  ETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPA--SPSYPRAEPL 1047
              Q              S+ +  ++P   P+ PP        G PPPA  +P  P+A P 
Sbjct: 264  PAQGG------------SKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPA 311

Query: 1048 ------TAPPTNGLP 1056
                    PP  G P
Sbjct: 312  GQPQGPPRPPQGGRP 326



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 88/332 (26%), Positives = 104/332 (31%), Gaps = 95/332 (28%)

Query: 718  QESPVISKDQSPPPSPPPSYHP--PPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPP 775
            +ESP +       PSP     P  PPPP  KP+              P Q  N P  PPP
Sbjct: 26   EESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQ------------GPPPQGGNKPQGPPP 73

Query: 776  APEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDP 835
              + Q       PPP+       S  P  P G P+    P     +      QP G P P
Sbjct: 74   PGKPQG------PPPQ----GDKSRSPRSPPGKPQ---GPPPQGGN------QPQGPPPP 114

Query: 836  PPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAP 895
            P  P  P P           PQ  P      G PP+ D              + RS  +P
Sbjct: 115  PGKPQGPPPQGG------NRPQGPPPPGKPQGPPPQGD--------------KSRSPRSP 154

Query: 896  GGAPT--PALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPN 953
             G P   P  G + PQ P          P P    G                     +P 
Sbjct: 155  PGKPQGPPPQGGNQPQGP---------PPPPGKPQG--------------PPPQGGKKPQ 191

Query: 954  GPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQ 1013
            GPP   P  PQ P           S +    +P  P  Q   Q            Q PP 
Sbjct: 192  GPPP--PGKPQGPPPQGD---KSRSSQSPPGKPQGPPPQGGNQ-----------PQGPPP 235

Query: 1014 APKKSPKAPPPVARKPSVGVPPPASPSYPRAE 1045
             P K P+ PPP       G PPP  P  P A+
Sbjct: 236  PPGK-PQGPPPQGGNKPQGPPPPGKPQGPPAQ 266



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 45/180 (25%), Positives = 65/180 (36%), Gaps = 30/180 (16%)

Query: 435 KGGSEGQPESSTASNSVVPPPQGGSG----------RGSPSGGSTAEASDTLSIRSSGQL 484
           +GG++ Q           PPPQGG            +G P  G  + +S +   +  G  
Sbjct: 164 QGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPGKPQGPP 223

Query: 485 SGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEG 544
                   + + PPPPP +      +G   P GP    P P + Q P     P  GGS+ 
Sbjct: 224 PQGG---NQPQGPPPPPGKPQGPPPQGGNKPQGP----PPPGKPQGP-----PAQGGSKS 271

Query: 545 AGAAPCPPNPA--------NSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPK 596
             A   P  P         N   P    GG+ + P++P            Q G P+ PP+
Sbjct: 272 QSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ 331


>gi|55750053 atrophin-1 [Homo sapiens]
          Length = 1190

 Score =  100 bits (249), Expect = 8e-21
 Identities = 180/714 (25%), Positives = 236/714 (33%), Gaps = 153/714 (21%)

Query: 453  PP--PQGG---SGRGSPSGGSTAEASDT-LSIRSSGQLSGRSVSLRKLKRPPPPPRRTHS 506
            PP  P+GG   S  G P+GG       T +S+ SSG                 PP +  +
Sbjct: 231  PPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGA-------------PPTKPPT 277

Query: 507  LHQRGLAVPDGPLGLPPKPERKQQPQLPRPPT-------TGGSEGAGAAPCPPNPANSWV 559
                G  +P  P   PP       P LP PP        +    G GA P P +  +   
Sbjct: 278  TPVGGGNLPSAP---PPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHA 334

Query: 560  PGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSL 619
             G   GG    P  PE+              PTL P   + PPAS     PP     +S 
Sbjct: 335  MGQGMGGL---PPGPEKG-------------PTLAPSPHSLPPASSSAPAPPMRFPYSSS 378

Query: 620  RSPGASVSSSLTSLCSSSSDPAPSDR---SGPQILTPLGDRFVIPPHPKVPAPFSPPPS- 675
             S  A+ SSS +S  SSS+ P P+ +   S P    P     V    PK   P  P  + 
Sbjct: 379  SSSSAAASSS-SSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAV 437

Query: 676  ---KPRSPNPAAPALAAPAVVPGPV-STTDASPQSPPTPQTTLTPLQESPVISKDQSPPP 731
                P  P P    LA     PGP   +T A   + P   T     Q+     + Q    
Sbjct: 438  WSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQ 497

Query: 732  SPPPSYH---PPPPPTKKPEVVVEAPS--ASETAEEPLQDPNWPPPPPPAPEEQDLSMAD 786
                 +H    PPPP   P  +    S  A   A  P      P PP P         A 
Sbjct: 498  QQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGP---------AH 548

Query: 787  FPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAP-- 844
             PPP     S  S   AGP+G P   SS ++SS+S  +     P     P   P P P  
Sbjct: 549  LPPPH----SQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPV 604

Query: 845  -----------------ASSAPGHVAKLPQKEP--------VGCSKGGGPPREDVGAPLV 879
                             ASS  G+    P   P         G  K   PP    G+P  
Sbjct: 605  PTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSP-- 662

Query: 880  TPSLLQMV--RLRSVGAPG-------GAPTPALGPSAPQKPLRRALSGRASPVPAPSSGL 930
             PS         R    P        G+PT   GP  P  P    L     P  AP+SG 
Sbjct: 663  -PSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGP--SGLPSLPPPPAAPASGP 719

Query: 931  H-AAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSP 989
              +A ++K      +E   + +   PP   P PP       S           L+R  + 
Sbjct: 720  PLSATQIKQ---EPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNS 776

Query: 990  ETQADL-------------QRNLVAELRSISEQRPPQAPKKSPKAPPPVARK-------- 1028
              ++DL             + +LV ++R  +EQR  +  ++  +      R+        
Sbjct: 777  CARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELE 836

Query: 1029 ---------------PSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELA 1067
                           PS+G  P   P  P +   T PP  G      RT  E A
Sbjct: 837  RSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYA 890



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 180/764 (23%), Positives = 257/764 (33%), Gaps = 149/764 (19%)

Query: 373  SLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSH----SQSSDTIVSD 428
            S +T  +  +  AS   V   GR   +S  +    +    + T          SD    D
Sbjct: 50   SRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLD 109

Query: 429  GSTLSSKGGSEGQP---ESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLS 485
            G +L+  G S+ +    ++ + S S+  P            GS    SD+ S  S G   
Sbjct: 110  GRSLNDDGSSDPRDIDQDNRSTSPSIYSP------------GSVENDSDSSSGLSQGPAR 157

Query: 486  GRSVSLRKLKRPPPP---PRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLP--RPPT-- 538
                       P PP   PR+  +  +   +V       P +P   +  Q P   PP   
Sbjct: 158  PYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHP 217

Query: 539  ---TGGSEGAGAAPCPPNP----ANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTP 591
                GG+ G  + P P  P    A S V G + G    PP +P    S  +  +  +  P
Sbjct: 218  QLYPGGTGGVLSGP-PMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPP 276

Query: 592  TLPPKG----LAGPPASPGKAQP--PKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDR 645
            T P  G     A PPA+     P  P P  +  L +  AS            + P P   
Sbjct: 277  TTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGL-------GAQPLPGHL 329

Query: 646  SGPQILTP-LGDRFVIPPHPK-----VPAPFSPPPSKPRSPNP-------AAPALAAPAV 692
              P  +   +G    +PP P+      P+P S PP+   +P P       ++ + +A A 
Sbjct: 330  PSPHAMGQGMGG---LPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAAS 386

Query: 693  VPGPVSTTDASP----QSPPT------PQTTLTPLQESPVISKDQSP--------PPSPP 734
                 S++ ASP    Q+ P+      P T+L+   + P  ++   P        PP PP
Sbjct: 387  SSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPP 446

Query: 735  P--------SYHPPP-PPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMA 785
            P        + HP P PP+   +     P ++       Q            ++Q     
Sbjct: 447  PYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGN 506

Query: 786  DFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPA 845
              PPP  AF     P P    G     + P A S S  +L+  PPG    PP  P    +
Sbjct: 507  SGPPPPGAF-----PHPL--EGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPP--PHSQVS 557

Query: 846  SSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGP 905
             S  G     P   PV  S            P   PS  Q         P GAP P    
Sbjct: 558  YSQAG-----PNGPPVSSSSNSSSSTSQGSYPCSHPSPSQ--------GPQGAPYPF--- 601

Query: 906  SAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQS 965
                            PVP  ++       + A   ++  G  +A P GPP    R P  
Sbjct: 602  ---------------PPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAP-- 644

Query: 966  PASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPV 1025
                     S G+ K        P +    +       R  S   PP  P       P V
Sbjct: 645  ---------SPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTS---PPAGPGTFKPGSPTV 692

Query: 1026 ARKPSVGVPPPASPS-YPRAEPLTAPPTNGLPHTQDRTKRELAE 1068
               P     PPA PS  P   P  A P +G P +  + K+E AE
Sbjct: 693  GPGPL----PPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAE 732



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 209/881 (23%), Positives = 290/881 (32%), Gaps = 172/881 (19%)

Query: 23  RRKKSRSGASGLRRAFSWLRGKRRKKKAAGAEGAEPAAP--RAKKAEDKAKRAKGKGRGS 80
           + K S S  SG ++     R + R +  A   G   ++   +A+K+   AK+A+ +   +
Sbjct: 5   QNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEAST 64

Query: 81  AKAENDKHLSVGPGQGPGSAVDEHQ-DNVFFPSGRPPHLEELHTQAQEGLRSLQHQEKQK 139
            K            QG    + E + +    P       E    Q+   L SL   + + 
Sbjct: 65  PKVNK---------QGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSL---DGRS 112

Query: 140 LNKGGWDHGDTQSIQSSRTGPDEDNISFCSQTTSYVAESSTAEDALSIRSEMIQRKGSTF 199
           LN  G    D + I       D+DN S    T+  +    + E+     S + Q     +
Sbjct: 113 LNDDG--SSDPRDI-------DQDNRS----TSPSIYSPGSVENDSDSSSGLSQGPARPY 159

Query: 200 RPHDSFPKSGK---SGRRRRER----RSTVLGLPQHVQKELGLRNEREAP-GTPRA---- 247
            P   FP S +   S  R+ E       +V     H   E       +AP G P      
Sbjct: 160 HPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQL 219

Query: 248 -PGARDAVRIPTVDGRPRGTSGMGARVSLQALEAEAEAGAETEAMLQRHIDRVYRDDTFV 306
            PG    V    + G P G  G GA  S+                               
Sbjct: 220 YPGGTGGV----LSGPPMGPKGGGAASSVG------------------------------ 245

Query: 307 GRSTGTRAPPLTRPMSLAVPGLTGGAGPAEPLSPA----MSISPQATYLSKLIPHAVLPP 362
           G + G + PP T P+S++  G +G      P +P     +  +P       + P+   PP
Sbjct: 246 GPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPP 305

Query: 363 TVDVVALGRCSLRTLSRCSL--HSASP-ASVRSLGRF------SSVSSPQPRSRHPSSSS 413
            +  +     S   L    L  H  SP A  + +G            +P P S  P+SSS
Sbjct: 306 ALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSS 365

Query: 414 D-------TWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTAS-NSVVPPPQGGSGRGSPS 465
                    +S S SS    S  S+ SS   S      +  S     PPP   S    P 
Sbjct: 366 APAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPP 425

Query: 466 GGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKP 525
              T  +  + ++ S G              PPPPP      + R LA  +   G P  P
Sbjct: 426 -KYTQPSLPSQAVWSQGP-------------PPPPP------YGRLLANSNAHPG-PFPP 464

Query: 526 ERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYS 585
               Q     P +T                          G+  PP  P     P  G S
Sbjct: 465 STGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPP-PPGAFPHPLEGGS 523

Query: 586 SQSGTP-TLPPKGLAGPPASPGKAQPPKPERVTSL-----RSPGASVSSSLTSLCSSSSD 639
           S    P  + P   +  P  PG A  P P    S        P  S SS+ +S  S  S 
Sbjct: 524 SHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSY 583

Query: 640 PA--PSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPV 697
           P   PS   GPQ                 P PF P P+   S    +  +A  A  P   
Sbjct: 584 PCSHPSPSQGPQ---------------GAPYPFPPVPTVTTSSATLSTVIATVASSPAGY 628

Query: 698 STTDASPQSPPTPQTTLTPLQESPVISKDQSPP---PSPPPSYHPPPPPTKKPEVVVEAP 754
            T  ASP  PP P     P   SP   K  +PP   P  PPS+    PP  +      +P
Sbjct: 629 KT--ASPPGPP-PYGKRAP---SPGAYKTATPPGYKPGSPPSFRTGTPPGYRG----TSP 678

Query: 755 SASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSS 814
            A     +P      P P PPA       +   PPP           PA P+  P L   
Sbjct: 679 PAGPGTFKPGSPTVGPGPLPPAGPS---GLPSLPPP-----------PAAPASGPPL--- 721

Query: 815 PAASSSSATALQIQPPGSPDPPPAPPAPAP-ASSAPGHVAK 854
            A       A + + P SP PP   P+P P     P H ++
Sbjct: 722 SATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQ 762


>gi|55750041 atrophin-1 [Homo sapiens]
          Length = 1190

 Score =  100 bits (249), Expect = 8e-21
 Identities = 180/714 (25%), Positives = 236/714 (33%), Gaps = 153/714 (21%)

Query: 453  PP--PQGG---SGRGSPSGGSTAEASDT-LSIRSSGQLSGRSVSLRKLKRPPPPPRRTHS 506
            PP  P+GG   S  G P+GG       T +S+ SSG                 PP +  +
Sbjct: 231  PPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGA-------------PPTKPPT 277

Query: 507  LHQRGLAVPDGPLGLPPKPERKQQPQLPRPPT-------TGGSEGAGAAPCPPNPANSWV 559
                G  +P  P   PP       P LP PP        +    G GA P P +  +   
Sbjct: 278  TPVGGGNLPSAP---PPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHA 334

Query: 560  PGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSL 619
             G   GG    P  PE+              PTL P   + PPAS     PP     +S 
Sbjct: 335  MGQGMGGL---PPGPEKG-------------PTLAPSPHSLPPASSSAPAPPMRFPYSSS 378

Query: 620  RSPGASVSSSLTSLCSSSSDPAPSDR---SGPQILTPLGDRFVIPPHPKVPAPFSPPPS- 675
             S  A+ SSS +S  SSS+ P P+ +   S P    P     V    PK   P  P  + 
Sbjct: 379  SSSSAAASSS-SSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAV 437

Query: 676  ---KPRSPNPAAPALAAPAVVPGPV-STTDASPQSPPTPQTTLTPLQESPVISKDQSPPP 731
                P  P P    LA     PGP   +T A   + P   T     Q+     + Q    
Sbjct: 438  WSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQ 497

Query: 732  SPPPSYH---PPPPPTKKPEVVVEAPS--ASETAEEPLQDPNWPPPPPPAPEEQDLSMAD 786
                 +H    PPPP   P  +    S  A   A  P      P PP P         A 
Sbjct: 498  QQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGP---------AH 548

Query: 787  FPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAP-- 844
             PPP     S  S   AGP+G P   SS ++SS+S  +     P     P   P P P  
Sbjct: 549  LPPPH----SQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPV 604

Query: 845  -----------------ASSAPGHVAKLPQKEP--------VGCSKGGGPPREDVGAPLV 879
                             ASS  G+    P   P         G  K   PP    G+P  
Sbjct: 605  PTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSP-- 662

Query: 880  TPSLLQMV--RLRSVGAPG-------GAPTPALGPSAPQKPLRRALSGRASPVPAPSSGL 930
             PS         R    P        G+PT   GP  P  P    L     P  AP+SG 
Sbjct: 663  -PSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGP--SGLPSLPPPPAAPASGP 719

Query: 931  H-AAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSP 989
              +A ++K      +E   + +   PP   P PP       S           L+R  + 
Sbjct: 720  PLSATQIKQ---EPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNS 776

Query: 990  ETQADL-------------QRNLVAELRSISEQRPPQAPKKSPKAPPPVARK-------- 1028
              ++DL             + +LV ++R  +EQR  +  ++  +      R+        
Sbjct: 777  CARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELE 836

Query: 1029 ---------------PSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELA 1067
                           PS+G  P   P  P +   T PP  G      RT  E A
Sbjct: 837  RSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYA 890



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 180/764 (23%), Positives = 257/764 (33%), Gaps = 149/764 (19%)

Query: 373  SLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSH----SQSSDTIVSD 428
            S +T  +  +  AS   V   GR   +S  +    +    + T          SD    D
Sbjct: 50   SRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLD 109

Query: 429  GSTLSSKGGSEGQP---ESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLS 485
            G +L+  G S+ +    ++ + S S+  P            GS    SD+ S  S G   
Sbjct: 110  GRSLNDDGSSDPRDIDQDNRSTSPSIYSP------------GSVENDSDSSSGLSQGPAR 157

Query: 486  GRSVSLRKLKRPPPP---PRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLP--RPPT-- 538
                       P PP   PR+  +  +   +V       P +P   +  Q P   PP   
Sbjct: 158  PYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHP 217

Query: 539  ---TGGSEGAGAAPCPPNP----ANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTP 591
                GG+ G  + P P  P    A S V G + G    PP +P    S  +  +  +  P
Sbjct: 218  QLYPGGTGGVLSGP-PMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPP 276

Query: 592  TLPPKG----LAGPPASPGKAQP--PKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDR 645
            T P  G     A PPA+     P  P P  +  L +  AS            + P P   
Sbjct: 277  TTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGL-------GAQPLPGHL 329

Query: 646  SGPQILTP-LGDRFVIPPHPK-----VPAPFSPPPSKPRSPNP-------AAPALAAPAV 692
              P  +   +G    +PP P+      P+P S PP+   +P P       ++ + +A A 
Sbjct: 330  PSPHAMGQGMGG---LPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAAS 386

Query: 693  VPGPVSTTDASP----QSPPT------PQTTLTPLQESPVISKDQSP--------PPSPP 734
                 S++ ASP    Q+ P+      P T+L+   + P  ++   P        PP PP
Sbjct: 387  SSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPP 446

Query: 735  P--------SYHPPP-PPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMA 785
            P        + HP P PP+   +     P ++       Q            ++Q     
Sbjct: 447  PYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGN 506

Query: 786  DFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPA 845
              PPP  AF     P P    G     + P A S S  +L+  PPG    PP  P    +
Sbjct: 507  SGPPPPGAF-----PHPL--EGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPP--PHSQVS 557

Query: 846  SSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGP 905
             S  G     P   PV  S            P   PS  Q         P GAP P    
Sbjct: 558  YSQAG-----PNGPPVSSSSNSSSSTSQGSYPCSHPSPSQ--------GPQGAPYPF--- 601

Query: 906  SAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQS 965
                            PVP  ++       + A   ++  G  +A P GPP    R P  
Sbjct: 602  ---------------PPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAP-- 644

Query: 966  PASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPV 1025
                     S G+ K        P +    +       R  S   PP  P       P V
Sbjct: 645  ---------SPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTS---PPAGPGTFKPGSPTV 692

Query: 1026 ARKPSVGVPPPASPS-YPRAEPLTAPPTNGLPHTQDRTKRELAE 1068
               P     PPA PS  P   P  A P +G P +  + K+E AE
Sbjct: 693  GPGPL----PPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAE 732



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 209/881 (23%), Positives = 290/881 (32%), Gaps = 172/881 (19%)

Query: 23  RRKKSRSGASGLRRAFSWLRGKRRKKKAAGAEGAEPAAP--RAKKAEDKAKRAKGKGRGS 80
           + K S S  SG ++     R + R +  A   G   ++   +A+K+   AK+A+ +   +
Sbjct: 5   QNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEAST 64

Query: 81  AKAENDKHLSVGPGQGPGSAVDEHQ-DNVFFPSGRPPHLEELHTQAQEGLRSLQHQEKQK 139
            K            QG    + E + +    P       E    Q+   L SL   + + 
Sbjct: 65  PKVNK---------QGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSL---DGRS 112

Query: 140 LNKGGWDHGDTQSIQSSRTGPDEDNISFCSQTTSYVAESSTAEDALSIRSEMIQRKGSTF 199
           LN  G    D + I       D+DN S    T+  +    + E+     S + Q     +
Sbjct: 113 LNDDG--SSDPRDI-------DQDNRS----TSPSIYSPGSVENDSDSSSGLSQGPARPY 159

Query: 200 RPHDSFPKSGK---SGRRRRER----RSTVLGLPQHVQKELGLRNEREAP-GTPRA---- 247
            P   FP S +   S  R+ E       +V     H   E       +AP G P      
Sbjct: 160 HPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQL 219

Query: 248 -PGARDAVRIPTVDGRPRGTSGMGARVSLQALEAEAEAGAETEAMLQRHIDRVYRDDTFV 306
            PG    V    + G P G  G GA  S+                               
Sbjct: 220 YPGGTGGV----LSGPPMGPKGGGAASSVG------------------------------ 245

Query: 307 GRSTGTRAPPLTRPMSLAVPGLTGGAGPAEPLSPA----MSISPQATYLSKLIPHAVLPP 362
           G + G + PP T P+S++  G +G      P +P     +  +P       + P+   PP
Sbjct: 246 GPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPP 305

Query: 363 TVDVVALGRCSLRTLSRCSL--HSASP-ASVRSLGRF------SSVSSPQPRSRHPSSSS 413
            +  +     S   L    L  H  SP A  + +G            +P P S  P+SSS
Sbjct: 306 ALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSS 365

Query: 414 D-------TWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTAS-NSVVPPPQGGSGRGSPS 465
                    +S S SS    S  S+ SS   S      +  S     PPP   S    P 
Sbjct: 366 APAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPP 425

Query: 466 GGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKP 525
              T  +  + ++ S G              PPPPP      + R LA  +   G P  P
Sbjct: 426 -KYTQPSLPSQAVWSQGP-------------PPPPP------YGRLLANSNAHPG-PFPP 464

Query: 526 ERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYS 585
               Q     P +T                          G+  PP  P     P  G S
Sbjct: 465 STGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPP-PPGAFPHPLEGGS 523

Query: 586 SQSGTP-TLPPKGLAGPPASPGKAQPPKPERVTSL-----RSPGASVSSSLTSLCSSSSD 639
           S    P  + P   +  P  PG A  P P    S        P  S SS+ +S  S  S 
Sbjct: 524 SHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSY 583

Query: 640 PA--PSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPV 697
           P   PS   GPQ                 P PF P P+   S    +  +A  A  P   
Sbjct: 584 PCSHPSPSQGPQ---------------GAPYPFPPVPTVTTSSATLSTVIATVASSPAGY 628

Query: 698 STTDASPQSPPTPQTTLTPLQESPVISKDQSPP---PSPPPSYHPPPPPTKKPEVVVEAP 754
            T  ASP  PP P     P   SP   K  +PP   P  PPS+    PP  +      +P
Sbjct: 629 KT--ASPPGPP-PYGKRAP---SPGAYKTATPPGYKPGSPPSFRTGTPPGYRG----TSP 678

Query: 755 SASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSS 814
            A     +P      P P PPA       +   PPP           PA P+  P L   
Sbjct: 679 PAGPGTFKPGSPTVGPGPLPPAGPS---GLPSLPPP-----------PAAPASGPPL--- 721

Query: 815 PAASSSSATALQIQPPGSPDPPPAPPAPAP-ASSAPGHVAK 854
            A       A + + P SP PP   P+P P     P H ++
Sbjct: 722 SATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQ 762


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score =  100 bits (249), Expect = 8e-21
 Identities = 122/435 (28%), Positives = 160/435 (36%), Gaps = 93/435 (21%)

Query: 497 PPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAG-AAPCPPNPA 555
           PPPPP          L  P  PLG PP P     P      +   ++  G +A       
Sbjct: 6   PPPPP----------LPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQ 55

Query: 556 NSWVPGLSPGGSRRPPR--SPERTLSPSSGYSSQSGTPTLPPKG--LAG--PPASP---- 605
            + +  ++    R  P+  S + T     G ++  G  T P  G   AG  P   P    
Sbjct: 56  GTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQR 115

Query: 606 ----GKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIP 661
               GK       R  S R P  ++S  L         P  S R G       G     P
Sbjct: 116 DVAGGKTGQGPGSRAPSPRLPNKTISGPLI--------PPASPRLG-NTSEAHGAARTAP 166

Query: 662 PHPKVPAPFSPPPSKPRSPNPAAPALAAPAVV-------PGPVSTTD----------ASP 704
           P P VPAP  PPP+ P  P P  P L + + +       PGP++  +          A P
Sbjct: 167 PRPNVPAP--PPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPP 224

Query: 705 QSPPTPQTTLTPLQESPVIS-KDQSP-------PPSPPPSYHPPPPPTKKPEVVVEAPSA 756
             PP P  T  PL  + V+S K   P       PP PPP   P  PP   P +  E  S 
Sbjct: 225 PPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPL--PLLPPCGYPGLKAEPASP 282

Query: 757 SETAEEPLQDPNWPPPPPPAPEEQDLS-MADFP-PPEEAFFSVASPEPAGPSGSPELVSS 814
           ++ A+EP      P PPPP P     S  A  P PP     S +   P  P  SP   + 
Sbjct: 283 AQDAQEP------PAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAP 336

Query: 815 PAASSSSATALQIQPPGSP------------------DPPPAPPAPAP----ASSAPGHV 852
           P  + + A      PPGS                   +PPPAPPA +P    +S +    
Sbjct: 337 PQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQAT 396

Query: 853 AKLPQKEPVGCSKGG 867
           A  P ++P G  + G
Sbjct: 397 AWTPTQQPGGQLRNG 411



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 118/456 (25%), Positives = 147/456 (32%), Gaps = 100/456 (21%)

Query: 591 PTLPPKGLAGPPASPGKAQPPKPER------VTSLRSPGASVSSSLTSLCSSSSD----P 640
           P  PP  L  PP   G   PP P         +SLR       S+L +     +      
Sbjct: 4   PPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVT 63

Query: 641 APSDRSGPQI-----------------------------------LTPLGDRFVI----- 660
             +DRS PQI                                   L P G R V      
Sbjct: 64  QINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTG 123

Query: 661 -PPHPKVPAPFSP---------PPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTP 710
             P  + P+P  P         PP+ PR  N +    AA    P P       P  PP P
Sbjct: 124 QGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPP 183

Query: 711 QTTLTPLQESPVISKDQSPPPSP----------------PPSYHPPPPPTKKPEVVVEAP 754
                PL  S  I      PP P                PP   PPPPPT  P  +  A 
Sbjct: 184 PPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPP--LPPAS 241

Query: 755 SASETAEEPLQDP-NWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVS 813
             S+ A +P   P + PP PPP P               +    A   PA P   P   S
Sbjct: 242 VLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYAS 301

Query: 814 SPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPRED 873
               +S  A  L      S  PPP PP  +P+  AP      PQK   G      PP   
Sbjct: 302 CSPRASLPAPPLPGVNSSSETPPPLPP-KSPSFQAP------PQK--AGAQALPAPP--- 349

Query: 874 VGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAA 933
             AP  +   LQ  R    GA GG   P   P+ P +     LS ++    A +      
Sbjct: 350 --APPGSQPFLQKKRHGRPGAGGGKLNPP--PAPPARSPTTELSSKSQQATAWTPTQQPG 405

Query: 934 VRLKACSLAASEGLSS-----AQPNGPPEAEPRPPQ 964
            +L+  SL   +   S     +  + PP  E +P Q
Sbjct: 406 GQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQ 441



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 104/391 (26%), Positives = 135/391 (34%), Gaps = 95/391 (24%)

Query: 426 VSDGSTLSSKGGSEGQPE--SSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQ 483
           V+ G T    G     P   + T S  ++PP        SP  G+T+EA    + R++  
Sbjct: 117 VAGGKTGQGPGSRAPSPRLPNKTISGPLIPP-------ASPRLGNTSEAHG--AARTAPP 167

Query: 484 LSGRSVSLRKLKRPPPPPRR----THSLHQRGLAVPDGPLG-------LPPKPERKQQPQ 532
                        PPPPP      + S  +  L  P GPL         PP P     P 
Sbjct: 168 RPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPP 227

Query: 533 LPRPPTTGGSEGAGAAPCPPNPANS---WVPGLSPGGSRRPPRSPERTLSPSSGYSSQSG 589
            P PPT          P PP    S     P L+P     PP  P   L P  GY     
Sbjct: 228 PPPPPTP--------PPLPPASVLSDKAVKPQLAP--LHLPPIPPPLPLLPPCGYPGLKA 277

Query: 590 TPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQ 649
            P  P +    PPA P    PP P   +   SP AS+ +      +SSS+          
Sbjct: 278 EPASPAQDAQEPPAPP----PPLPPYASC--SPRASLPAPPLPGVNSSSE---------- 321

Query: 650 ILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPT 709
                                +PPP  P+SP+  AP   A A          A P +PP 
Sbjct: 322 ---------------------TPPPLPPKSPSFQAPPQKAGA---------QALP-APPA 350

Query: 710 PQTTLTPLQESPVISKDQSPPPSPPPSYHPPP-PPTKKPEVVVEAPSASETAEEPLQDPN 768
           P  +   LQ+     K    P +     +PPP PP + P   + + S   TA  P Q P 
Sbjct: 351 PPGSQPFLQK-----KRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPG 405

Query: 769 WPPPPPPAPEEQDL-------SMADFPPPEE 792
                       D        S+ DFPPP+E
Sbjct: 406 GQLRNGSLHIIDDFESKFTFHSVEDFPPPDE 436



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 98/411 (23%), Positives = 130/411 (31%), Gaps = 61/411 (14%)

Query: 660  IPPHPKVPAPFSPPP-SKPRSPNPAAPALAAPAVVPGPVSTTDASPQ--SPPTPQTTLTP 716
            +PP P  P P  PPP   P  P P+AP          PVST  +S +   P      L  
Sbjct: 3    VPPPPPPPLPPPPPPLGAPPPPPPSAP----------PVSTDTSSLRRADPKGRSALLAD 52

Query: 717  LQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPA 776
            +Q+   + K         P         K+         AS             P   PA
Sbjct: 53   IQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPA 112

Query: 777  PEEQDLSMADFPPPEEAFFSVASPE-----PAGPSGSPELVSSPAASSSSATA-----LQ 826
             +           P     S   P      P  P  SP L ++  A  ++ TA     + 
Sbjct: 113  GQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVP 172

Query: 827  IQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQM 886
              PP +P PPP P  P   SS+P    K P   P G    G  P      P   P     
Sbjct: 173  APPPPTPPPPPPPLPPPLPSSSP---IKTPLVSPPGPLTKGNLPVVAPPVPCAPPP---- 225

Query: 887  VRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRA-SPVPAPSSGLHAAVRLKACSLAASE 945
                        P P   P+ P  P    LS +A  P  AP         L         
Sbjct: 226  ------------PPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYP 273

Query: 946  GLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRS 1005
            GL  A+P  P +    PP  P     +  +  S +  L  P  P   +            
Sbjct: 274  GLK-AEPASPAQDAQEPPAPPPPLPPY--ASCSPRASLPAPPLPGVNS------------ 318

Query: 1006 ISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLP 1056
             S + PP  P KSP    P  +  +  +P P +P  P ++P      +G P
Sbjct: 319  -SSETPPPLPPKSPSFQAPPQKAGAQALPAPPAP--PGSQPFLQKKRHGRP 366



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 54/224 (24%), Positives = 74/224 (33%), Gaps = 22/224 (9%)

Query: 829  PPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVR 888
            P   P PPP PP P P  + P      P   PV          +  G   +   + Q  R
Sbjct: 2    PVPPPPPPPLPPPPPPLGAPP---PPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTR 58

Query: 889  LRSVGAPGGAPTPALGPS-APQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGL 947
            LR V        P +  S    K    + + R +  P P+ G   A        A    +
Sbjct: 59   LRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTP-PTLGDLFAGGFPVLRPAGQRDV 117

Query: 948  SSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSIS 1007
            +  +    P +    P+ P  T S           L  P SP      +    +E    +
Sbjct: 118  AGGKTGQGPGSRAPSPRLPNKTISG---------PLIPPASP------RLGNTSEAHGAA 162

Query: 1008 EQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPP 1051
               PP+     P  PPP    P   +PPP   S P   PL +PP
Sbjct: 163  RTAPPR--PNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPP 204



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 51/193 (26%), Positives = 64/193 (33%), Gaps = 34/193 (17%)

Query: 515 PDGPLGLPPKPERKQQPQLPRPPTTG-GSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRS 573
           P  P  LPP      +  LP PP  G  S      P PP   +   P    G    P   
Sbjct: 290 PAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALP--- 346

Query: 574 PERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSL 633
                +P +   SQ   P L  K    P A  GK  PP          P  S ++ L+S 
Sbjct: 347 -----APPAPPGSQ---PFLQKKRHGRPGAGGGKLNPPP-------APPARSPTTELSSK 391

Query: 634 CSSSSDPAPSDRSGPQ-------ILTPLGDRFVI-------PPHPKVPAPFSPPPSKPRS 679
              ++   P+ + G Q       I+     +F         PP    P     P   PRS
Sbjct: 392 SQQATAWTPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRS 451

Query: 680 PNPAAPALAAPAV 692
             P  P L A AV
Sbjct: 452 RTP-GPWLQAEAV 463


>gi|153792074 proline rich 12 [Homo sapiens]
          Length = 2036

 Score =  100 bits (249), Expect = 8e-21
 Identities = 154/643 (23%), Positives = 218/643 (33%), Gaps = 92/643 (14%)

Query: 461  RGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAV----PD 516
            +G   GG T E   T  +            L+K   PPPP  ++      GL +    PD
Sbjct: 730  KGPERGGETPEGLATSVVHYGAGAKELGAFLQKSPPPPPPTAQSTQPTPHGLLLEAGGPD 789

Query: 517  GPLGLPPKPERKQQPQLPRPPTTGGS--------------EGAGAAPCPPNPANSWVP-- 560
             PL LPP P +     L   P+   S              +GA   P PP P    +P  
Sbjct: 790  LPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPLQ 849

Query: 561  --------GLSPGGSRRPPRSPERTLSPSSGYSSQSGT----PTLPPKGLAGPPASPGKA 608
                    GL P     P   PE +L P        G     P  P     GPP S GK 
Sbjct: 850  LEAHLRSHGLEPAAPS-PRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGK- 907

Query: 609  QPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPA 668
             P    R  S +   A     LTS+C   S     +RS    +  +        + K   
Sbjct: 908  DPAGAYRSPSPQGTKAPRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAADDYGKA-- 965

Query: 669  PFSPPPSKPRSPNPAAPALAAPAVVP-GPVSTTDASPQSPPTPQTTLTPLQESPVISKDQ 727
               PP  +      A P    PA  P GP     AS   P TP   L P +   + S   
Sbjct: 966  --GPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVN 1023

Query: 728  SPP------------PSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPN------W 769
            + P            P PPP   PPP P  +P+  + +P    T  + L   +       
Sbjct: 1024 AEPLGLIQSGPHQAAPPPPPPPPPPPAPASEPKGGLTSPIFCSTKPKKLLKTSSFHLLRR 1083

Query: 770  PPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQP 829
              PP   P++      +F   E+    V +     P   P+LVSS  +  +      + P
Sbjct: 1084 RDPPFQTPKKLYAQEYEFEADEDK-ADVPADIRLNPRRLPDLVSSCRSRPA------LSP 1136

Query: 830  PGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRL 889
             G  D  P    P P    P    + P K     +K  GPPR   G P + P     + +
Sbjct: 1137 LGDIDFCP----PNPGPDGPRRRGRKPTK-----AKRDGPPRPR-GRPRIRP-----LEV 1181

Query: 890  RSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSS 949
             +   P  A TP  G   P +   R    +A             +++K     A EGL +
Sbjct: 1182 PTTAGPASASTPTDGAKKP-RGRGRGRGRKAEEAGGTRLEPLKPLKIKLSVPKAGEGLGT 1240

Query: 950  AQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQ 1009
            +  +     +     S     S    K   K++      PE ++    + +  L+S  ++
Sbjct: 1241 SSGDAISGTDHNSLDS-----SLTREKIEAKIKEVEEKQPEMKSGFMASFLDFLKS-GKR 1294

Query: 1010 RPP------QAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEP 1046
             PP        P   PK+ PP      +   PPA+P+ P   P
Sbjct: 1295 HPPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPHPPP 1337



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 164/676 (24%), Positives = 234/676 (34%), Gaps = 122/676 (18%)

Query: 455  PQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPR------------ 502
            P+ G G G+ SG + +  +D  S+ SS         +++++   P  +            
Sbjct: 1232 PKAGEGLGTSSGDAIS-GTDHNSLDSSLTREKIEAKIKEVEEKQPEMKSGFMASFLDFLK 1290

Query: 503  ---RTHSLHQRGLAVP-DGPLGLPPK-PERKQQPQ------LPRPPTTGGSEGAGAAPCP 551
               R   L+Q GL  P   P  +PP  P R  QPQ      +P PP +G     GA    
Sbjct: 1291 SGKRHPPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEA- 1349

Query: 552  PNPANSWVPGLS-PGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQP 610
               A S   GL  P   +R     +R L     +SS                        
Sbjct: 1350 ---AESEGLGLGCPSPCKRLDEELKRNLETLPSFSSD----------------------- 1383

Query: 611  PKPERVTSLRSPGASVSSSLTSLCSSSSDP---APSDRSGPQILTPLGDRFVIPPHPKVP 667
             + + V   R    S+SS++++L     DP    P D S P    PL     +P  P +P
Sbjct: 1384 -EEDSVAKNRDLQESISSAISAL----DDPPLAGPKDTSTPDG-PPLAPAAAVPGPPPLP 1437

Query: 668  APFSPPPSKPRSPNPAAPALAA-PAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKD 726
                  PS   +  P  P L   P   P P  T    P  PP P     P     V    
Sbjct: 1438 GL----PSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTP 1493

Query: 727  QSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMAD 786
             SPPP P P   PPPPP          P+A+  A  P +     P  P  P+ + L +A 
Sbjct: 1494 SSPPPPPLP---PPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDTRPLHLA- 1549

Query: 787  FPPPEEAFFSVASPEPAGPSGSPELVSSP---AASSSSATALQIQPPGSPDPPPAPPAPA 843
                E A     + E AG SG   +          +    +L++      +PPP      
Sbjct: 1550 -KKQETAAVCGETDEEAGESGGEGIFRERDEFVIRAEDIPSLKLALQTGREPPPIWRVQK 1608

Query: 844  PASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPAL 903
                      K  Q++    S   G      G        L +  L +V         A 
Sbjct: 1609 ALLQKFTPEIKDGQRQFCATSNYLG----YFGDAKNRYQRLYVKFLENVNKKDYVRVCAR 1664

Query: 904  GP-SAPQKPLRRALSGRA-SPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPR 961
             P   P  P+RR  SG+A +PV                    S G SSA P   P A P 
Sbjct: 1665 KPWHRPPVPVRR--SGQAKNPV--------------------SAGGSSAPPPKAP-APPP 1701

Query: 962  PPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKA 1021
             P++P  T S    + + +  +  P +PE  + L+   V + +   +    + P +  +A
Sbjct: 1702 KPETPEKTTSEKPPEQTPETAMPEPPAPEKPSLLRP--VEKEKEKEKVTRGERPLRGERA 1759

Query: 1022 PPPVARKP--SVGVPPPASPSYPRAEPL---TAPPTNGLPHTQDRTKRELAENGGVLQLV 1076
                  +P  S+    PA+   P+A P      PP         + K+ L E GG     
Sbjct: 1760 TSGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPK-------KRKKWLKEAGGNATAG 1812

Query: 1077 GPEEKMGLPGSDSQKE 1092
            G     G PGS S  E
Sbjct: 1813 G-----GPPGSSSDSE 1823



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 208/892 (23%), Positives = 266/892 (29%), Gaps = 258/892 (28%)

Query: 312  TRAPPLTRPMSLAVPGLTGGAGPAEPL-----SPAMSISPQATYLSKLIPHAVLPPTVDV 366
            TR PP   P S A P      GPA        S A     QA   S   P  +L P    
Sbjct: 404  TRPPP---PRSTATPKCQSLGGPAAAYATGKASGAGGAGGQA--YSPGQPQGLLGPQAYG 458

Query: 367  VALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIV 426
               G    + LS+   +S  P              PQP S  P     T   S S D + 
Sbjct: 459  QGFGGGQAQDLSKAPSYSGGP--------------PQPPSGPPPPGLAT-CQSYSPDQLQ 503

Query: 427  SD----------GSTLSSKGGSEGQPESS--TASNSVVPPPQGGSGRGSPSGGSTAEASD 474
                        G    S+G     P  S  T  +  +    GG G  S  GG  A  S 
Sbjct: 504  GQLYGVQGEPYPGPAAHSQGLPTASPSLSYSTGHSPALSGHGGGWGPSSLGGGGEASPSH 563

Query: 475  TLSIRSSGQLSGRSVSLRKLKRP--------------PPPPRRTHSLHQRG--------- 511
             +    S   +GR   +     P               PP   +++    G         
Sbjct: 564  IIRPLQSPPATGRPPGVGSPGAPGKYLSSVLASAPFLAPPGAGSYAAGAGGYKGKGDGSE 623

Query: 512  -LAVPDGPLGLPPKPER---KQQPQLPRPPTTGGSEGA----GAAPCPPNPANSWVPGLS 563
             LA P GP     + E    +   Q P PP T G++G     GAA            GL 
Sbjct: 624  LLAGPGGPPAERTEDEEFLIQHLLQAPSPPRTSGADGLVGEDGAADASK--------GLG 675

Query: 564  PGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPER--VTSLRS 621
              G                              G  GPP +P +     P+R  + S+  
Sbjct: 676  GSG------------------------------GAGGPPGTPYELAKEDPQRYHLQSVIR 705

Query: 622  PGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPN 681
              AS+    T+            + GP+                                
Sbjct: 706  TSASLDEGATAALELGLGRLKEKKKGPE---------------------------RGGET 738

Query: 682  PAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPP 741
            P   A +      G         +SPP P  T    Q +P     ++  P  P    PPP
Sbjct: 739  PEGLATSVVHYGAGAKELGAFLQKSPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVL-PPP 797

Query: 742  PPTKKPEVVVEAPSASETA--------EEPLQD--PNWPPPPPPAPEEQDLSMADFPPPE 791
            PP   P V+  APS S +A        E   +D  P  PPPPPP P    L +       
Sbjct: 798  PPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPLQL------- 850

Query: 792  EAFFSVASPEPAGPSGS---PELVSSPAASSSSATALQIQPPGSPDPPPAPPA-----PA 843
            EA       EPA PS      E +  P A      AL+  PP   D    PP      PA
Sbjct: 851  EAHLRSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPA 910

Query: 844  PASSAPG-HVAKLPQKEPVGC---------------------SKGGGP--------PRED 873
             A  +P     K P+  P+                         GGG         P ED
Sbjct: 911  GAYRSPSPQGTKAPRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAADDYGKAGPPED 970

Query: 874  VGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPV----PAPSSG 929
             G P               G P G P  A  P  P  P R + +G  +P     P     
Sbjct: 971  EGDPKA-----------GAGPPPGPP--AYDPYGPYCPGRASGAGPETPGLGLDPNKPPE 1017

Query: 930  LHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPAS------TASFIFSKGSRKLQ- 982
            L + V  +   L  S    +A P  PP   P PP +PAS      T+    S   +KL  
Sbjct: 1018 LPSTVNAEPLGLIQSGPHQAAPPPPPP---PPPPPAPASEPKGGLTSPIFCSTKPKKLLK 1074

Query: 983  ------LERPVSP-----------------ETQADLQRNL------VAELRSISEQRPPQ 1013
                  L R   P                 E +AD+  ++      + +L S    RP  
Sbjct: 1075 TSSFHLLRRRDPPFQTPKKLYAQEYEFEADEDKADVPADIRLNPRRLPDLVSSCRSRPAL 1134

Query: 1014 AP---------KKSPKAPPPVARKPSVGVP--PPASPSYPRAEPLTAPPTNG 1054
            +P            P  P    RKP+      PP     PR  PL  P T G
Sbjct: 1135 SPLGDIDFCPPNPGPDGPRRRGRKPTKAKRDGPPRPRGRPRIRPLEVPTTAG 1186



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 193/819 (23%), Positives = 257/819 (31%), Gaps = 135/819 (16%)

Query: 384  SASP-ASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQP 442
            SA P ASV +L        PQP     S  S   S S  +       + L   G   G  
Sbjct: 81   SAGPDASVMNLISALESRGPQPGPSASSLLSQFRSPSWQTAMHTPGPTELFISGALPGSS 140

Query: 443  E--SSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPP 500
               SS+A ++   P   GS R  P   S +      S  ++G LS   V   K  + P  
Sbjct: 141  TFPSSSALSAYQHPASFGS-RPFPVPSSLSLQDPPFSPPANGLLSPHDVLHLKPSQAPTV 199

Query: 501  PRRTHSLHQRGLAVPDGPLGLPPK---PERKQQPQLPRPPT---------TGGSEGA--- 545
            P         G  V  GP GL P    P R   P  P PP             S  A   
Sbjct: 200  PSSLGFERLAGGGVL-GPAGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAA 258

Query: 546  -----------GAAPCPPNPANSWVPGLS--------PGGSRRPPRSP-----ERTLSPS 581
                       GAAP PP P  + +P           P  ++ PP  P     +  LS  
Sbjct: 259  EQSSPQLYNFSGAAPGPPPPERA-LPRQDTVIKHYQRPASAQPPPPPPPAHALQHYLSCG 317

Query: 582  SGYSSQSGTPTLPPKGLAGPPASPGKAQPPK--PERVTSLRSPGASVSSSLTSLCSSSSD 639
              Y S      L    L G   SPG  +P K  P   T+    GAS  ++          
Sbjct: 318  GSYPSMGHRANLACSPLGGGEPSPGAGEPSKAGPSGATA----GASGRATGPEAAGGGGA 373

Query: 640  PAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVST 699
                    P I +P G +     +       + PP    +  P   +L  PA        
Sbjct: 374  GGGGGGYRPIIQSP-GYKTGKGGYGAAAGGATRPPPPRSTATPKCQSLGGPAAAYATGKA 432

Query: 700  TDA-----SPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYH--PPPPPT--KKPEVV 750
            + A        SP  PQ  L P          Q+   S  PSY   PP PP+    P + 
Sbjct: 433  SGAGGAGGQAYSPGQPQGLLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQPPSGPPPPGLA 492

Query: 751  VEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSG--S 808
                 + +  +  L      P P PA   Q L  A    P  ++ +  SP  +G  G   
Sbjct: 493  TCQSYSPDQLQGQLYGVQGEPYPGPAAHSQGLPTAS---PSLSYSTGHSPALSGHGGGWG 549

Query: 809  PELVSSPAASSSSATALQIQPPGSPDPPPAPPAP-APASSAPGHVAKLPQKEPVGCS--- 864
            P  +     +S S     +Q P +   PP   +P AP       +A  P   P G     
Sbjct: 550  PSSLGGGGEASPSHIIRPLQSPPATGRPPGVGSPGAPGKYLSSVLASAPFLAPPGAGSYA 609

Query: 865  ------KG-----------GGPPREDV-GAPLVTPSLLQMV------------------- 887
                  KG           GGPP E       +   LLQ                     
Sbjct: 610  AGAGGYKGKGDGSELLAGPGGPPAERTEDEEFLIQHLLQAPSPPRTSGADGLVGEDGAAD 669

Query: 888  RLRSVGAPGGAPTPALGP--SAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASE 945
              + +G  GGA  P   P   A + P R  L        +   G  AA+ L         
Sbjct: 670  ASKGLGGSGGAGGPPGTPYELAKEDPQRYHLQSVIRTSASLDEGATAALEL-------GL 722

Query: 946  GLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRK----LQLERPVSPETQADLQ---RN 998
            G    +  GP      P     +T+   +  G+++    LQ   P  P T    Q     
Sbjct: 723  GRLKEKKKGPERGGETP--EGLATSVVHYGAGAKELGAFLQKSPPPPPPTAQSTQPTPHG 780

Query: 999  LVAE-----LRSISEQRPPQ-APKKSPKAPPPVARKPSVGV---PPPASPSYPRAEPLTA 1049
            L+ E     L  +    PPQ  P     AP P      VGV    P      P+  P   
Sbjct: 781  LLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPP 840

Query: 1050 PPTNGLP-HTQDRTKRELAENGGVLQLVGPEEKMGLPGS 1087
            PP   +P   +   +    E       + PEE +  PG+
Sbjct: 841  PPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGA 879



 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 131/596 (21%), Positives = 184/596 (30%), Gaps = 124/596 (20%)

Query: 315  PPLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCSL 374
            PPL+ P S+       G  P  P +PA             +PH   PP      LG    
Sbjct: 1305 PPLSPPKSVPPSVPARGLQPQPPATPA-------------VPH---PPPSGAFGLG---- 1344

Query: 375  RTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSS 434
                     +   A    LG    +  P P  R      +   + ++  +  SD     +
Sbjct: 1345 --------GALEAAESEGLG----LGCPSPCKR---LDEELKRNLETLPSFSSDEEDSVA 1389

Query: 435  KGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEAS------DTLSIRSSGQLSGRS 488
            K     +  SS  S    PP  G     +P G   A A+          + S+       
Sbjct: 1390 KNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSANSNGTPE 1449

Query: 489  VSLRKLKRPP-PPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGA 547
              L + K PP PPP  T             P   PP P    QP LP PP          
Sbjct: 1450 PPLLEEKPPPTPPPAPT-------------PQPQPPPPPPPPQPALPSPPPL-------V 1489

Query: 548  APCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGK 607
            AP P +P    +P   P     PP  P    +P                 LA PP  P  
Sbjct: 1490 APTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAP-----------------LAAPPEEPAA 1532

Query: 608  AQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIP----PH 663
              P  PE +   R    +      ++C  + + A    SG + +    D FVI     P 
Sbjct: 1533 PSPEDPE-LPDTRPLHLAKKQETAAVCGETDEEA--GESGGEGIFRERDEFVIRAEDIPS 1589

Query: 664  PKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDAS------PQSPPTPQTTLTPL 717
             K+       P        A      P +  G       S        +    Q      
Sbjct: 1590 LKLALQTGREPPPIWRVQKALLQKFTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVKF 1649

Query: 718  QESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAP 777
             E+ V  KD     +  P +H PP P ++        SA  ++  P +     P PPP P
Sbjct: 1650 LEN-VNKKDYVRVCARKP-WHRPPVPVRRSGQAKNPVSAGGSSAPPPK----APAPPPKP 1703

Query: 778  EEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELV---------------SSPAASSSSA 822
            E  + + ++ PP +      A PEP  P   P L+                 P     + 
Sbjct: 1704 ETPEKTTSEKPPEQTP--ETAMPEPPAPE-KPSLLRPVEKEKEKEKVTRGERPLRGERAT 1760

Query: 823  TALQIQP--------PGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPP 870
            +  Q +P        P +   P A P    A   P    K  ++     + GGGPP
Sbjct: 1761 SGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPKKRKKWLKEAGGNATAGGGPP 1816



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 128/551 (23%), Positives = 181/551 (32%), Gaps = 90/551 (16%)

Query: 453  PPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPP-PPPRRTHSLHQRG 511
            PPP   +    P GG T+      S +    L   S  L + + PP   P++ ++     
Sbjct: 1044 PPPPPPAPASEPKGGLTSPIF--CSTKPKKLLKTSSFHLLRRRDPPFQTPKKLYAQEYEF 1101

Query: 512  LAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAP------CPPNPANSWVPGLSPG 565
             A  D      P   R    +LP   ++  S  A  +P      CPPNP         P 
Sbjct: 1102 EA--DEDKADVPADIRLNPRRLPDLVSSCRSRPA-LSPLGDIDFCPPNPG--------PD 1150

Query: 566  GSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPP-----KPE-----R 615
            G RR  R P  T +   G     G P + P  +    A P  A  P     KP      R
Sbjct: 1151 GPRRRGRKP--TKAKRDGPPRPRGRPRIRPLEVP-TTAGPASASTPTDGAKKPRGRGRGR 1207

Query: 616  VTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPP- 674
                   G +    L  L    S P    ++G  + T  GD      H  + +  +    
Sbjct: 1208 GRKAEEAGGTRLEPLKPLKIKLSVP----KAGEGLGTSSGDAISGTDHNSLDSSLTREKI 1263

Query: 675  -SKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSP---- 729
             +K +      P + +   +   +    +  + PP  Q  LTP    P       P    
Sbjct: 1264 EAKIKEVEEKQPEMKS-GFMASFLDFLKSGKRHPPLYQAGLTPPLSPPKSVPPSVPARGL 1322

Query: 730  ---PPSPPPSYHPPPPPTKKPEVVVEA----------PSASETAEEPLQDPNWPPPPPPA 776
               PP+ P   HPPP         +EA          PS  +  +E L+  N    P  +
Sbjct: 1323 QPQPPATPAVPHPPPSGAFGLGGALEAAESEGLGLGCPSPCKRLDEELKR-NLETLPSFS 1381

Query: 777  PEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPP 836
             +E+D S+A     +E+  S  S     P   P+  S+P     +  A        P PP
Sbjct: 1382 SDEED-SVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAA------AVPGPP 1434

Query: 837  PAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGP-PREDVGAPLVTPSLLQMVRLRSVGAP 895
            P P  P+  S+       L +K P        P P+     P   P+L           P
Sbjct: 1435 PLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSP-------PP 1487

Query: 896  GGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGP 955
              APTP+  P  P  P          P P P+          A  LA       A P  P
Sbjct: 1488 LVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPA----------AAPLA-------APPEEP 1530

Query: 956  PEAEPRPPQSP 966
                P  P+ P
Sbjct: 1531 AAPSPEDPELP 1541



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 54/238 (22%), Positives = 83/238 (34%), Gaps = 33/238 (13%)

Query: 478  IRSSGQLS------GRSVSLRKLKRPPP------------PPRRTHSLHQRGLAVPDGPL 519
            +R SGQ        G S    K   PPP            PP +T          P+ P 
Sbjct: 1674 VRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKPS 1733

Query: 520  GLPPKPERKQQPQLPRP--PTTGGSEGAGAAPCPPN------PANSWVPGLSPGGSRR-- 569
             L P  + K++ ++ R   P  G    +G    P        PA S +P   P   +   
Sbjct: 1734 LLRPVEKEKEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEP 1793

Query: 570  PPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSS 629
            PP+  ++ L  + G ++  G P          P +P + +   P R+   R+      S 
Sbjct: 1794 PPKKRKKWLKEAGGNATAGGGPPGSSSDSESSPGAPSEDERAVPGRLLKTRAMREMYRSY 1853

Query: 630  LTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPAL 687
            +  L S++ DP        Q L    D   +PP  K+    +    K       +PAL
Sbjct: 1854 VEMLVSTALDP-----DMIQALEDTHDELYLPPMRKIDGLLNEHKKKVLKRLSLSPAL 1906



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 46/189 (24%), Positives = 64/189 (33%), Gaps = 22/189 (11%)

Query: 672  PPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPP 731
            PP    RS     P  A  +  P P      +P  PP P+T        P  +  + PP 
Sbjct: 1670 PPVPVRRSGQAKNPVSAGGSSAPPP-----KAPAPPPKPET--------PEKTTSEKPPE 1716

Query: 732  SPPPSYHPPPPPTKKPEVV--VEAPSASE---TAEEPLQDPNWPPPPPPAPEEQDLSMAD 786
              P +  P PP  +KP ++  VE     E     E PL+           PE    S+A 
Sbjct: 1717 QTPETAMPEPPAPEKPSLLRPVEKEKEKEKVTRGERPLRGERATSGRQTRPER---SLAT 1773

Query: 787  FPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPAS 846
              P           +        +       +  +ATA    P  S D   +P AP+   
Sbjct: 1774 GQPATSRLPKARPTKVKAEPPPKKRKKWLKEAGGNATAGGGPPGSSSDSESSPGAPSEDE 1833

Query: 847  SA-PGHVAK 854
             A PG + K
Sbjct: 1834 RAVPGRLLK 1842



 Score = 33.9 bits (76), Expect = 0.86
 Identities = 39/175 (22%), Positives = 57/175 (32%), Gaps = 45/175 (25%)

Query: 640  PAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVST 699
            P P  RSG Q   P+       P PK PAP  P P  P       P          P  T
Sbjct: 1671 PVPVRRSG-QAKNPVSAGGSSAPPPKAPAP-PPKPETPEKTTSEKP----------PEQT 1718

Query: 700  TDASPQSPPTPQ--TTLTPLQ---ESPVISKDQSP------------------------- 729
             + +   PP P+  + L P++   E   +++ + P                         
Sbjct: 1719 PETAMPEPPAPEKPSLLRPVEKEKEKEKVTRGERPLRGERATSGRQTRPERSLATGQPAT 1778

Query: 730  ---PPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQD 781
               P + P      PPP K+ + + EA   +     P    +     P AP E +
Sbjct: 1779 SRLPKARPTKVKAEPPPKKRKKWLKEAGGNATAGGGPPGSSSDSESSPGAPSEDE 1833



 Score = 30.8 bits (68), Expect = 7.3
 Identities = 21/68 (30%), Positives = 30/68 (44%), Gaps = 2/68 (2%)

Query: 15   PGNPGGPPRRKKSRSGASGLRRAFSWLRGKRRKKKAAGAEGAEPAAPRAKKAEDKAKRAK 74
            P NPG    R++ R      R      RG+ R +       A PA+  A    D AK+ +
Sbjct: 1144 PPNPGPDGPRRRGRKPTKAKRDGPPRPRGRPRIRPLEVPTTAGPAS--ASTPTDGAKKPR 1201

Query: 75   GKGRGSAK 82
            G+GRG  +
Sbjct: 1202 GRGRGRGR 1209


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.127    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,541,965
Number of Sequences: 37866
Number of extensions: 5285100
Number of successful extensions: 113619
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1103
Number of HSP's successfully gapped in prelim test: 3122
Number of HSP's that attempted gapping in prelim test: 28044
Number of HSP's gapped (non-prelim): 37822
length of query: 1094
length of database: 18,247,518
effective HSP length: 113
effective length of query: 981
effective length of database: 13,968,660
effective search space: 13703255460
effective search space used: 13703255460
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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