Guide to the Human Genome
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Search of human proteins with 169208593

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169208593 PREDICTED: similar to kinase D-interacting
substrate 220 [Homo sapiens]
         (380 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169208819 PREDICTED: similar to kinase D-interacting substrat...   757   0.0  
gi|169208593 PREDICTED: similar to kinase D-interacting substrat...   757   0.0  
gi|169208169 PREDICTED: similar to kinase D-interacting substrat...   754   0.0  
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                    78   1e-14
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]             77   2e-14
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                    75   7e-14
gi|89941470 ankyrin repeat domain 34 [Homo sapiens]                    74   2e-13
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...    74   2e-13
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...    74   2e-13
gi|38257146 ankyrin repeat domain 46 [Homo sapiens]                    70   2e-12
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...    70   3e-12
gi|20270347 ankyrin repeat domain 54 [Homo sapiens]                    70   3e-12
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...    70   4e-12
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]     68   1e-11
gi|70995267 ankyrin repeat domain 29 [Homo sapiens]                    67   3e-11
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    67   3e-11
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...    67   3e-11
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...    67   3e-11
gi|169167742 PREDICTED: ankyrin repeat domain 33B [Homo sapiens]       66   5e-11
gi|113416996 PREDICTED: ankyrin repeat domain 33B [Homo sapiens]       66   5e-11
gi|239742483 PREDICTED: ankyrin repeat domain 33B [Homo sapiens]       66   5e-11
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...    66   5e-11
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                     66   5e-11
gi|55770876 notch4 preproprotein [Homo sapiens]                        64   2e-10
gi|18079216 CASK interacting protein 1 [Homo sapiens]                  64   2e-10
gi|110431370 espin [Homo sapiens]                                      64   2e-10
gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain ...    63   4e-10
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                    63   4e-10
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   63   4e-10
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...    63   5e-10

>gi|169208819 PREDICTED: similar to kinase D-interacting substrate
           220 [Homo sapiens]
          Length = 380

 Score =  757 bits (1954), Expect = 0.0
 Identities = 380/380 (100%), Positives = 380/380 (100%)

Query: 1   MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP 60
           MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP
Sbjct: 1   MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP 60

Query: 61  ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP 120
           ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP
Sbjct: 61  ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP 120

Query: 121 VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA 180
           VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA
Sbjct: 121 VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA 180

Query: 181 AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS 240
           AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS
Sbjct: 181 AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS 240

Query: 241 GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG 300
           GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG
Sbjct: 241 GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG 300

Query: 301 APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS 360
           APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS
Sbjct: 301 APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS 360

Query: 361 VPGPNPWQAGTEAVVLRAQR 380
           VPGPNPWQAGTEAVVLRAQR
Sbjct: 361 VPGPNPWQAGTEAVVLRAQR 380


>gi|169208593 PREDICTED: similar to kinase D-interacting substrate
           220 [Homo sapiens]
          Length = 380

 Score =  757 bits (1954), Expect = 0.0
 Identities = 380/380 (100%), Positives = 380/380 (100%)

Query: 1   MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP 60
           MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP
Sbjct: 1   MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP 60

Query: 61  ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP 120
           ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP
Sbjct: 61  ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP 120

Query: 121 VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA 180
           VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA
Sbjct: 121 VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA 180

Query: 181 AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS 240
           AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS
Sbjct: 181 AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS 240

Query: 241 GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG 300
           GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG
Sbjct: 241 GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG 300

Query: 301 APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS 360
           APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS
Sbjct: 301 APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS 360

Query: 361 VPGPNPWQAGTEAVVLRAQR 380
           VPGPNPWQAGTEAVVLRAQR
Sbjct: 361 VPGPNPWQAGTEAVVLRAQR 380


>gi|169208169 PREDICTED: similar to kinase D-interacting substrate
           220 [Homo sapiens]
          Length = 380

 Score =  754 bits (1946), Expect = 0.0
 Identities = 379/380 (99%), Positives = 379/380 (99%)

Query: 1   MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP 60
           MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP
Sbjct: 1   MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP 60

Query: 61  ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP 120
           ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP
Sbjct: 61  ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP 120

Query: 121 VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA 180
           VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA
Sbjct: 121 VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA 180

Query: 181 AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS 240
           AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS
Sbjct: 181 AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS 240

Query: 241 GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG 300
           GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG
Sbjct: 241 GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG 300

Query: 301 APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS 360
           APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANAL VS
Sbjct: 301 APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALSVS 360

Query: 361 VPGPNPWQAGTEAVVLRAQR 380
           VPGPNPWQAGTEAVVLRAQR
Sbjct: 361 VPGPNPWQAGTEAVVLRAQR 380


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 54/161 (33%), Positives = 79/161 (49%), Gaps = 17/161 (10%)

Query: 40   IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
            ++C+   GR P +  + L +    A +    LE GA V   D  GRTAL ++C +GH++ 
Sbjct: 939  VNCKDADGR-PTLYILALENQLTMAEY---FLENGANVEASDAEGRTALHVSCWQGHMEM 994

Query: 100  VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQ 159
            VQ+L+ +  D  AAD+   S +  AA  GH  V++ L+      G  +D T   G TAL 
Sbjct: 995  VQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEH----GAVVDHTCNQGATALC 1050

Query: 160  LAAARGHGTCVQAL---------TGPWGRAAAAAAARGSNS 191
            +AA  GH   VQ L            +GR A   AA+  +S
Sbjct: 1051 IAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHS 1091



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 60/171 (35%), Positives = 80/171 (46%), Gaps = 17/171 (9%)

Query: 31  VLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSL 90
           VL  L ++     +E  RT  +V   L     R   +R LL+ GA+VN  D  GRT L+ 
Sbjct: 496 VLQLLVKAGAHVNSEDDRTSCIVRQALE----REDSIRTLLDNGASVNQCDSNGRTLLAN 551

Query: 91  ACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRT 150
           A   G LD V LLV    D E  D+ G++P+  AA  GH  V+  L+      G  ++ T
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLI----GCGANINHT 607

Query: 151 NRAGLTALQLAAARGHGTCVQAL---------TGPWGRAAAAAAARGSNSD 192
           ++ G TAL+ AA  GH   V AL              R A  AAA G + D
Sbjct: 608 DQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHED 658



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 55/168 (32%), Positives = 78/168 (46%), Gaps = 10/168 (5%)

Query: 6   DLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRAR 65
           D C + G    L A   G V +   +L+    + +D     GRTPL+ A  +      A 
Sbjct: 742 DHCDKDGMTPLLVAAYEGHVDVVDLLLEG--GADVDHTDNNGRTPLLAAASMG----HAS 795

Query: 66  FVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
            V  LL  GAAV+  D  GRT LS+A  +G+++ V+ L+    D    D AG +P+  AA
Sbjct: 796 VVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAA 855

Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
             GH  + E L+      G R +  +  G     LA+  GH  CVQ L
Sbjct: 856 FEGHRLICEALIEQ----GARTNEIDNDGRIPFILASQEGHYDCVQIL 899



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 45/128 (35%), Positives = 72/128 (56%), Gaps = 5/128 (3%)

Query: 47  GRTPLMVA-VGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQ 105
           GRT L VA + +P     A  V LL+++GA V+  D+ G T L +A   GH+D V LL++
Sbjct: 710 GRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769

Query: 106 FSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARG 165
              D +  D+ G +P++ AA+ GH +V+  L+      G  +D  +  G T L +A+A+G
Sbjct: 770 GGADVDHTDNNGRTPLLAAASMGHASVVNTLL----FWGAAVDSIDSEGRTVLSIASAQG 825

Query: 166 HGTCVQAL 173
           +   V+ L
Sbjct: 826 NVEVVRTL 833



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 28/72 (38%), Positives = 44/72 (61%)

Query: 65   RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWA 124
            + V+LL+E GA V+    +G TAL +A + GH+D VQ+L++   DP  AD  G + +  A
Sbjct: 1026 KVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVA 1085

Query: 125  AACGHGAVLEFL 136
            A  GH  +++ L
Sbjct: 1086 AKNGHSQIIKLL 1097



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 37/112 (33%), Positives = 54/112 (48%), Gaps = 9/112 (8%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
           V  LL  G  V+  D   RTAL  A   GH D V  L+Q   +   AD+ G + ++ AA 
Sbjct: 627 VSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAY 686

Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLA-----AARGHGTCVQAL 173
            GH  ++E L+      G  ++  +  G TAL +A     A++GH + V  L
Sbjct: 687 MGHREIVEHLLDH----GAEVNHEDVDGRTALSVAALCVPASKGHASVVSLL 734



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 52/191 (27%), Positives = 76/191 (39%), Gaps = 38/191 (19%)

Query: 14  RTFLEAMQA-GKVHLARFVLD-ALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
           RT L    A G V + R +LD  LD +  D   + G TPL +A       +       L+
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRD---DAGWTPLHMAAFEGHRLI----CEALI 867

Query: 72  EQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGA 131
           EQGA  N  D  GR    LA + GH D VQ+L++   + +     G + +  AA  GH  
Sbjct: 868 EQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRD 927

Query: 132 VLEFL-----------------------------VRSFRRLGLRLDRTNRAGLTALQLAA 162
           ++E L                                F   G  ++ ++  G TAL ++ 
Sbjct: 928 IVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSC 987

Query: 163 ARGHGTCVQAL 173
            +GH   VQ L
Sbjct: 988 WQGHMEMVQVL 998



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 6/84 (7%)

Query: 38   SIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHL 97
            +++D    QG T L +A            V++LLE GA  N  D+ GRTA+ +A + GH 
Sbjct: 1036 AVVDHTCNQGATALCIAA----QEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHS 1091

Query: 98   DAVQLLVQFSGDPEAADSAGNSPV 121
              ++LL ++     + +    SPV
Sbjct: 1092 QIIKLLEKYGA--SSLNGCSPSPV 1113


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 67/186 (36%), Positives = 87/186 (46%), Gaps = 14/186 (7%)

Query: 17  LEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAA 76
           L A  AG+    RF+L    R  +D R   G T L +A  L     R++ + +LL  GA 
Sbjct: 208 LVAAAAGRGAALRFLLARGAR--VDARDGAGATALGLAAALG----RSQDIEVLLGHGAD 261

Query: 77  VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
             +RD  GR+AL  A  RGHL AVQLLV    + +A D+ G +P+  A+  GH  V   L
Sbjct: 262 PGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCL 321

Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL----TGPWGRAAAAAAARGSNSD 192
           +      G ++D T     T L LAA RGHG  V  L      P  R   A  A+    D
Sbjct: 322 LDR----GAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGD 377

Query: 193 SPPGRP 198
            P   P
Sbjct: 378 LPQALP 383



 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 53/128 (41%), Positives = 61/128 (47%), Gaps = 7/128 (5%)

Query: 64  ARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMW 123
           A  V  LL QGA+V  RD  GRT L LA  RGH   V+LL+Q      A D AG + +  
Sbjct: 54  AGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHE 113

Query: 124 AAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL---TGPWGRA 180
           AA  GH  V E L++     G      +  GLT L  AAA GH      L    GP   A
Sbjct: 114 AAWHGHSRVAELLLQR----GASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAA 169

Query: 181 AAAAAARG 188
           A A  ARG
Sbjct: 170 AEAEDARG 177



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 68/220 (30%), Positives = 83/220 (37%), Gaps = 77/220 (35%)

Query: 40  IDCRAEQGRTPLMVAVGLPDPALR--ARFVRLLLEQGAAVNLRDERGRTALSLACERGHL 97
           ++ R   GRTPL +AV      LR  A  VRLLL++GA V   D  GRTAL  A   GH 
Sbjct: 67  VEERDHAGRTPLHLAV------LRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHS 120

Query: 98  DAVQLLVQFSGDPEAADSAGNSPVMWAAACG----------------------------- 128
              +LL+Q      A    G +P+ WAAA G                             
Sbjct: 121 RVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTA 180

Query: 129 --------HGAVLEFL----------------------VRSFRRLGLRLDRTNRAGLTAL 158
                     AVLE L                      +R     G R+D  + AG TAL
Sbjct: 181 AHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATAL 240

Query: 159 QLAAARGHGTCVQALTG---------PWGRAAA-AAAARG 188
            LAAA G    ++ L G           GR+A   AAARG
Sbjct: 241 GLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 75.5 bits (184), Expect = 7e-14
 Identities = 51/143 (35%), Positives = 73/143 (51%), Gaps = 8/143 (5%)

Query: 33  DALDRSIIDCRAEQGRTPLMVAV--GLPDPALRARFVRLLLEQGAAVNLRDERGRTALSL 90
           +A  ++ +D +   G+TPLM++V  G  D       V  LL +GA V+ +D+ GRTAL  
Sbjct: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTD------CVYSLLNKGANVDAKDKWGRTALHR 692

Query: 91  ACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRT 150
               GH + V  L+Q        DS G +P+  +AACGH  VL  L++S   +       
Sbjct: 693 GAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATA 752

Query: 151 NRAGLTALQLAAARGHGTCVQAL 173
           +  G TAL  A   GH TCV+ L
Sbjct: 753 DNHGYTALHWACYNGHETCVELL 775



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 51/173 (29%), Positives = 73/173 (42%), Gaps = 22/173 (12%)

Query: 33  DALDRSIIDCRA------EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRT 86
           D +   +IDC A      E+G TPL  A      AL    + LL+  GA VN++ + G+T
Sbjct: 252 DVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL---CLELLVGNGADVNMKSKDGKT 308

Query: 87  ALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLR 146
            L +    G     Q ++Q     +  D  GN+P+  AA  GH  ++  L+ S    G  
Sbjct: 309 PLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS----GAD 364

Query: 147 LDRTNRAGLTALQLAAARGHGTCVQALTG---------PWGRAAAAAAARGSN 190
             +    G+  L LAA  G   C + L            +GR    AAA G N
Sbjct: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGN 417



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 52/174 (29%), Positives = 77/174 (44%), Gaps = 10/174 (5%)

Query: 28  ARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTA 87
           A  ++D L  SI++    +GRTPL  A            ++LLL   A VN  D  G+T 
Sbjct: 804 AEMLIDTLGASIVNATDSKGRTPLHAAAFTD----HVECLQLLLSHNAQVNSVDSTGKTP 859

Query: 88  LSLACERGHLDAVQLLV-QFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLR 146
           L +A E G  + V++LV   S +    D++ N+ +  A + GH      ++       L 
Sbjct: 860 LMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL- 918

Query: 147 LDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSDSPPGRPAP 200
           ++ TN A  T L +AA  G    VQ L G      A+  A   N  +P    AP
Sbjct: 919 INATNAALQTPLHVAARNGLTMVVQELLG----KGASVLAVDENGYTPALACAP 968



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 46/134 (34%), Positives = 65/134 (48%), Gaps = 8/134 (5%)

Query: 40  IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
           ++ +  + RTPL  A  L D    A  + LL+  GA VN +D +  T L  A      +A
Sbjct: 34  VNFQDNEKRTPLHAAAYLGD----AEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEA 89

Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQ 159
           VQ+L++ S D  A D    +P+  AAA       E LV     + +    ++RAG TAL 
Sbjct: 90  VQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV----SDRAGRTALH 145

Query: 160 LAAARGHGTCVQAL 173
            AA  GHG  V+ L
Sbjct: 146 HAAFSGHGEMVKLL 159



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 40/142 (28%), Positives = 66/142 (46%), Gaps = 15/142 (10%)

Query: 43  RAEQGRTPLMVAVGLPDPALRA-----------RFVRLLLEQGAAVNLRDERGRTALSLA 91
           +  +   PL+  V + D A R              V+LLL +GA +N  D++ R A+  A
Sbjct: 121 KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA 180

Query: 92  CERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTN 151
              GH++ V+LLV    +    D    +P+  AA+ G  +V+++L+     LG+ ++  N
Sbjct: 181 AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL----DLGVDMNEPN 236

Query: 152 RAGLTALQLAAARGHGTCVQAL 173
             G T L +A   G    V  L
Sbjct: 237 AYGNTPLHVACYNGQDVVVNEL 258



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 47/199 (23%), Positives = 72/199 (36%), Gaps = 67/199 (33%)

Query: 38  SIIDCRAEQGRTPLMVAVGLPDPALRARFV-----------------------------R 68
           ++IDC  + G TPL +A       L    +                             R
Sbjct: 330 AVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCR 389

Query: 69  LLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA-C 127
            LL  G  ++  D+ GRT L  A   G+L+ + LL+    D    D  G SP+ +AAA C
Sbjct: 390 KLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANC 449

Query: 128 GH---------------------------------GAVLEFLVRSFRRLGLRLDRTNRAG 154
            +                                 G  LE+L+R+    G+R    ++ G
Sbjct: 450 NYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIR----DKQG 505

Query: 155 LTALQLAAARGHGTCVQAL 173
             A+  +AA GH  C+Q +
Sbjct: 506 YNAVHYSAAYGHRLCLQLI 524



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 34/125 (27%), Positives = 55/125 (44%), Gaps = 11/125 (8%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAAD-SAGNSPVMWAA 125
           + +L++    +++R+  GRT L LA  +GH++ V +L+         D     +P+  AA
Sbjct: 566 LEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAA 625

Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTG---------P 176
             GH   L  L+ +       +D  +  G T L L+   GH  CV +L            
Sbjct: 626 TNGHSECLRLLIGNAEPQN-AVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDK 684

Query: 177 WGRAA 181
           WGR A
Sbjct: 685 WGRTA 689



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 40/156 (25%), Positives = 68/156 (43%), Gaps = 13/156 (8%)

Query: 40  IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
           + C+ ++  TPL  A      +     V+ LL+ G  +N  +  G T L +AC  G    
Sbjct: 199 VTCKDKKSYTPLHAAAS----SGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVV 254

Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAV-LEFLVRSFRRLGLRLDRTNRAGLTAL 158
           V  L+         +  G +P+ +AAA  HGA+ LE LV +    G  ++  ++ G T L
Sbjct: 255 VNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGN----GADVNMKSKDGKTPL 310

Query: 159 QLAAARGHGTCVQALTGPWGRAAAAAAARGSNSDSP 194
            + A  G  +  Q +     ++ A       N ++P
Sbjct: 311 HMTALHGRFSRSQTII----QSGAVIDCEDKNGNTP 342



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 6/110 (5%)

Query: 69  LLLEQGAAVNLRDERGRTALS---LACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
           +L+E      L D   R  +S   LA   GH  A+++LVQ   D +  +S+G +P+  AA
Sbjct: 532 VLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAA 591

Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTG 175
             GH   ++ L+     + ++     R   T +  AA  GH  C++ L G
Sbjct: 592 FKGHVECVDVLINQGASILVKDYILKR---TPIHAAATNGHSECLRLLIG 638



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 43/158 (27%), Positives = 66/158 (41%), Gaps = 7/158 (4%)

Query: 19  AMQAGKVHLARFVLDALDRSIIDC--RAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAA 76
           A+  G V      +DAL +    C  R  +GRTP+ ++       +    ++      A 
Sbjct: 689 ALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDAN 748

Query: 77  VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
               D  G TAL  AC  GH   V+LL++     +   +A  SP+  A    +    E L
Sbjct: 749 PATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNA-FSPLHCAVINDNEGAAEML 807

Query: 137 VRSFRRLGLRL-DRTNRAGLTALQLAAARGHGTCVQAL 173
           + +   LG  + + T+  G T L  AA   H  C+Q L
Sbjct: 808 IDT---LGASIVNATDSKGRTPLHAAAFTDHVECLQLL 842


>gi|89941470 ankyrin repeat domain 34 [Homo sapiens]
          Length = 496

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 75/220 (34%), Positives = 94/220 (42%), Gaps = 36/220 (16%)

Query: 17  LEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVA--VGLPDPALRARFVRLLLEQG 74
           L A+  GK+ LAR +L+    + ++    QG T LM A      DP  +AR VR LLEQG
Sbjct: 10  LRAVGQGKLRLARLLLEG--GAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67

Query: 75  AAVNLRDERGRTALSLACERGHLDAV-QLLVQFSGDPEAADSAGNSPVMWAAACGHGAVL 133
           A  N+ D  GRTAL  AC  G   AV  LL+    DP   D AG S ++ A         
Sbjct: 68  ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHA--------- 118

Query: 134 EFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSDS 193
                        LDR +R  L  L L A +  GT V  +T     +      +  NS  
Sbjct: 119 -------------LDRGDRETLATL-LDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPP 164

Query: 194 PPG--RPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGG 231
            PG   PAPA+      PSP     P   +   A GG  G
Sbjct: 165 SPGVEDPAPAS------PSPGFCTSPSEIQLQTAGGGGRG 198


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 43/106 (40%), Positives = 59/106 (55%), Gaps = 4/106 (3%)

Query: 65   RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWA 124
            + VRLLLE+G  VNL D++GRT L +A   GHL  V+ L+       + D  G S + WA
Sbjct: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177

Query: 125  AACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCV 170
               GH AV+++LV      G  +D+T++ G T L LAA  G    V
Sbjct: 1178 CLKGHRAVVQYLVEE----GAAIDQTDKNGRTPLDLAAFYGDAETV 1219



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 45/127 (35%), Positives = 62/127 (48%), Gaps = 8/127 (6%)

Query: 47   GRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
            G T L  A G      +     LLL  GAAV+  + RG   L  A  +GH   V+LL++ 
Sbjct: 1071 GETALTAAAGRG----KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLER 1126

Query: 107  SGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
              D   +D  G +P+M AA  GH + +EFL+      G  L   ++ GL+AL  A  +GH
Sbjct: 1127 GCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSK----GAALSSLDKEGLSALSWACLKGH 1182

Query: 167  GTCVQAL 173
               VQ L
Sbjct: 1183 RAVVQYL 1189



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 54/182 (29%), Positives = 84/182 (46%), Gaps = 12/182 (6%)

Query: 10   RAGTRTFLEAMQAGKVHLARFVLD-ALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVR 68
            R G      A + G   + R +L+   D ++ D   +QGRTPLMVA      +     V 
Sbjct: 1102 RRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD---KQGRTPLMVAACEGHLST----VE 1154

Query: 69   LLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACG 128
             LL +GAA++  D+ G +ALS AC +GH   VQ LV+     +  D  G +P+  AA  G
Sbjct: 1155 FLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYG 1214

Query: 129  HGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARG 188
                + +LV      G  ++  + +G+  L  A    + + V AL     +   AA A  
Sbjct: 1215 DAETVLYLVEK----GAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMA 1270

Query: 189  SN 190
            ++
Sbjct: 1271 TS 1272



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 45/137 (32%), Positives = 60/137 (43%), Gaps = 17/137 (12%)

Query: 67   VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
            V LLLE GA ++   E G TAL  A   GH+  V LL +     +  D  G   ++ +A 
Sbjct: 943  VTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSAL 1002

Query: 127  CGHGAVLEFLVRSFRRLGLRLD---RTNRAGLTALQLAAARGHGTCVQALTGP------- 176
             GHG +L++L+      G       R + A   AL  AA+ GH + VQ L G        
Sbjct: 1003 RGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVE 1062

Query: 177  -------WGRAAAAAAA 186
                   WG  A  AAA
Sbjct: 1063 VNGTDTLWGETALTAAA 1079



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 39/113 (34%), Positives = 57/113 (50%), Gaps = 7/113 (6%)

Query: 68   RLLLEQGAAVNLRDERGRTA--LSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
            RLL+  GA VN R E    A  L +    GH + V LL++F    +     G + + +AA
Sbjct: 909  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968

Query: 126  ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQ-ALTGPW 177
            A GH  ++  L +     G+R+D  ++ G  AL  +A RGHG  +Q  LT  W
Sbjct: 969  AAGHMKLVCLLTKK----GVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEW 1017


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 43/106 (40%), Positives = 59/106 (55%), Gaps = 4/106 (3%)

Query: 65   RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWA 124
            + VRLLLE+G  VNL D++GRT L +A   GHL  V+ L+       + D  G S + WA
Sbjct: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185

Query: 125  AACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCV 170
               GH AV+++LV      G  +D+T++ G T L LAA  G    V
Sbjct: 1186 CLKGHRAVVQYLVEE----GAAIDQTDKNGRTPLDLAAFYGDAETV 1227



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 45/127 (35%), Positives = 62/127 (48%), Gaps = 8/127 (6%)

Query: 47   GRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
            G T L  A G      +     LLL  GAAV+  + RG   L  A  +GH   V+LL++ 
Sbjct: 1079 GETALTAAAGRG----KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLER 1134

Query: 107  SGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
              D   +D  G +P+M AA  GH + +EFL+      G  L   ++ GL+AL  A  +GH
Sbjct: 1135 GCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSK----GAALSSLDKEGLSALSWACLKGH 1190

Query: 167  GTCVQAL 173
               VQ L
Sbjct: 1191 RAVVQYL 1197



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 54/182 (29%), Positives = 84/182 (46%), Gaps = 12/182 (6%)

Query: 10   RAGTRTFLEAMQAGKVHLARFVLD-ALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVR 68
            R G      A + G   + R +L+   D ++ D   +QGRTPLMVA      +     V 
Sbjct: 1110 RRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD---KQGRTPLMVAACEGHLST----VE 1162

Query: 69   LLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACG 128
             LL +GAA++  D+ G +ALS AC +GH   VQ LV+     +  D  G +P+  AA  G
Sbjct: 1163 FLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYG 1222

Query: 129  HGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARG 188
                + +LV      G  ++  + +G+  L  A    + + V AL     +   AA A  
Sbjct: 1223 DAETVLYLVEK----GAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMA 1278

Query: 189  SN 190
            ++
Sbjct: 1279 TS 1280



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 45/137 (32%), Positives = 60/137 (43%), Gaps = 17/137 (12%)

Query: 67   VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
            V LLLE GA ++   E G TAL  A   GH+  V LL +     +  D  G   ++ +A 
Sbjct: 951  VTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSAL 1010

Query: 127  CGHGAVLEFLVRSFRRLGLRLD---RTNRAGLTALQLAAARGHGTCVQALTGP------- 176
             GHG +L++L+      G       R + A   AL  AA+ GH + VQ L G        
Sbjct: 1011 RGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVE 1070

Query: 177  -------WGRAAAAAAA 186
                   WG  A  AAA
Sbjct: 1071 VNGTDTLWGETALTAAA 1087



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 39/113 (34%), Positives = 57/113 (50%), Gaps = 7/113 (6%)

Query: 68   RLLLEQGAAVNLRDERGRTA--LSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
            RLL+  GA VN R E    A  L +    GH + V LL++F    +     G + + +AA
Sbjct: 917  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976

Query: 126  ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQ-ALTGPW 177
            A GH  ++  L +     G+R+D  ++ G  AL  +A RGHG  +Q  LT  W
Sbjct: 977  AAGHMKLVCLLTKK----GVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEW 1025


>gi|38257146 ankyrin repeat domain 46 [Homo sapiens]
          Length = 228

 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 43/100 (43%), Positives = 56/100 (56%), Gaps = 7/100 (7%)

Query: 66  FVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
           + + LLE G   N+RD RGRT L LA  RG++D  QLL +F  D  A D  GN+ +    
Sbjct: 27  YSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL---H 83

Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARG 165
            CGH   ++FLV +    GL++D  N  G T L LA  RG
Sbjct: 84  LCGHVDTIQFLVSN----GLKIDICNHQGATPLVLAKRRG 119


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 50/136 (36%), Positives = 67/136 (49%), Gaps = 17/136 (12%)

Query: 38  SIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHL 97
           +++ C A++G  P++             F+   LE   A++  D+ GRTA   A E G L
Sbjct: 126 TLLHCAAQKGHVPVLA------------FIMEDLED-VALDHVDKLGRTAFHRAAEHGQL 172

Query: 98  DAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTA 157
           DA+  LV    D    D  GN+ +  AA  GH AVL+ LV     +GL L+  N  GLTA
Sbjct: 173 DALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLV----DIGLDLEEQNAEGLTA 228

Query: 158 LQLAAARGHGTCVQAL 173
           L  AA   H  CVQ L
Sbjct: 229 LHSAAGGSHPDCVQLL 244



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 43/149 (28%), Positives = 69/149 (46%), Gaps = 12/149 (8%)

Query: 19  AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAV--GLPDPALRARFVRLLLEQGAA 76
           A Q G V +  F+++ L+   +D   + GRT    A   G  D       +  L+  G  
Sbjct: 131 AAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDA------LDFLVGSGCD 184

Query: 77  VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
            N++D+ G TAL LA  RGH+  +Q LV    D E  ++ G + +  AA   H   ++ L
Sbjct: 185 HNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLL 244

Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAARG 165
           +R+    G  ++   +  L+ L  AA  G
Sbjct: 245 LRA----GSTVNALTQKNLSCLHYAALSG 269



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 45/143 (31%), Positives = 58/143 (40%), Gaps = 16/143 (11%)

Query: 43  RAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGR----------TALSLAC 92
           R   GR  L  A G    A   + VRLLLE  AAV+  D  G            AL L+ 
Sbjct: 44  RNHVGRVALHWAAG----AGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSA 99

Query: 93  ERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNR 152
             GHL  +Q+LV            G + +  AA  GH  VL F++       + LD  ++
Sbjct: 100 WFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLE--DVALDHVDK 157

Query: 153 AGLTALQLAAARGHGTCVQALTG 175
            G TA   AA  G    +  L G
Sbjct: 158 LGRTAFHRAAEHGQLDALDFLVG 180



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 30/96 (31%), Positives = 47/96 (48%), Gaps = 4/96 (4%)

Query: 46  QGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQ 105
           QG +PL +AV    PAL    VRLL+   + VN  D R +T L LA E    D   +L+ 
Sbjct: 290 QGASPLHLAVRHNFPAL----VRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLI 345

Query: 106 FSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFR 141
              D    D  G + +  A    H ++++ ++++ R
Sbjct: 346 AGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADR 381



 Score = 36.2 bits (82), Expect = 0.050
 Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 12/169 (7%)

Query: 6   DLCPRAGTRTFLEAMQAGKVHLARFVLDA-LDRSIIDCRAEQGRTPLMVAVGLPDPALRA 64
           D   + G   F  A + G++    F++ +  D ++ D   ++G T L +A G    A+  
Sbjct: 153 DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKD---KEGNTALHLAAGRGHMAVLQ 209

Query: 65  RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWA 124
           R V +    G  +  ++  G TAL  A    H D VQLL++      A      S + +A
Sbjct: 210 RLVDI----GLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYA 265

Query: 125 AACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
           A  G   V   L+ +    G   +  +  G + L LA        V+ L
Sbjct: 266 ALSGSEDVSRVLIHA----GGCANVVDHQGASPLHLAVRHNFPALVRLL 310


>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
          Length = 300

 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 44/113 (38%), Positives = 60/113 (53%), Gaps = 10/113 (8%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
           V+ LLE GA     D++GRTAL  A   G+   VQLL+    DP   D  GN+P+  AA 
Sbjct: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185

Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAAR------GHGTCVQAL 173
             H  V+  L+R     G R+D  +RAG T L LA ++      GH  C++A+
Sbjct: 186 TNHVPVITTLLRG----GARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 26/76 (34%), Positives = 37/76 (48%), Gaps = 6/76 (7%)

Query: 65  RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWA 124
           + V+LLL+ GA  N RD  G T L LA    H+  +  L++     +A D AG +P+  A
Sbjct: 157 QIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216

Query: 125 AAC------GHGAVLE 134
            +       GH   LE
Sbjct: 217 KSKLNILQEGHAQCLE 232


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 51/168 (30%), Positives = 76/168 (45%), Gaps = 16/168 (9%)

Query: 14   RTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQ--------GRTPLMVAVGLPDPALRAR 65
            +  + A   G   +  ++LD  ++   +    Q        G T L  A G      +  
Sbjct: 993  QALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRG----KLE 1048

Query: 66   FVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
              RLLLEQGAAV   + RG   L     +GH   V LL+    D   AD  G +P+M AA
Sbjct: 1049 VCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAA 1108

Query: 126  ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
            + GH   ++FL+      G  +   ++ GLTAL  A  +GH + V++L
Sbjct: 1109 SEGHLGTVDFLLAQ----GASIALMDKEGLTALSWACLKGHLSVVRSL 1152



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 44/117 (37%), Positives = 61/117 (52%), Gaps = 8/117 (6%)

Query: 45   EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLV 104
            +QGRTPLM+A            V  LL QGA++ L D+ G TALS AC +GHL  V+ LV
Sbjct: 1098 KQGRTPLMMAASEGHLGT----VDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLV 1153

Query: 105  QFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLA 161
                  + AD  G +P+  AA  G   V++FLV      G  ++  + +G+  L  A
Sbjct: 1154 DNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDH----GAMIEHVDYSGMRPLDRA 1206



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 50/162 (30%), Positives = 70/162 (43%), Gaps = 10/162 (6%)

Query: 12   GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
            G      A   GK+ + R +L+    + +     +G  PL   V         + V LLL
Sbjct: 1034 GETALTAAAGRGKLEVCRLLLE--QGAAVAQPNRRGAVPLFSTVRQG----HWQIVDLLL 1087

Query: 72   EQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGA 131
              GA VN+ D++GRT L +A   GHL  V  L+         D  G + + WA   GH +
Sbjct: 1088 THGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLS 1147

Query: 132  VLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
            V+  LV +    G   D  ++ G T L LAA  G    VQ L
Sbjct: 1148 VVRSLVDN----GAATDHADKNGRTPLDLAAFYGDAEVVQFL 1185



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 27/78 (34%), Positives = 41/78 (52%)

Query: 67   VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
            VR L++ GAA +  D+ GRT L LA   G  + VQ LV      E  D +G  P+  A  
Sbjct: 1149 VRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVG 1208

Query: 127  CGHGAVLEFLVRSFRRLG 144
            C + +V+  L++   ++G
Sbjct: 1209 CRNTSVVVTLLKKGAKIG 1226



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 27/72 (37%), Positives = 37/72 (51%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
           V LLLE GA V+   E G T L  A   G+L  V LL +     +  D  G   ++ AA 
Sbjct: 901 VALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAAL 960

Query: 127 CGHGAVLEFLVR 138
            GH  V++FL++
Sbjct: 961 RGHLEVVKFLIQ 972


>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
          Length = 1050

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 45/131 (34%), Positives = 66/131 (50%), Gaps = 5/131 (3%)

Query: 43  RAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQL 102
           R ++G TPL VA      +L    + LL+ +GA VN  D  G T L LAC++G+     L
Sbjct: 459 RDDRGHTPLHVAAVCGQASL----IDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLL 514

Query: 103 LVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAA 162
           L+ +    E  D+ GN+P+  A   GH   ++ LV  +     RLD  N  G T L +AA
Sbjct: 515 LLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALV-YYDVESCRLDIGNEKGDTPLHIAA 573

Query: 163 ARGHGTCVQAL 173
             G+   ++ L
Sbjct: 574 RWGYQGVIETL 584



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 42/136 (30%), Positives = 69/136 (50%), Gaps = 12/136 (8%)

Query: 40  IDCRAEQGRTPLMVAVGLPDPAL--RARFVRLLLEQGAAVNLRDERGRTALSLACERGHL 97
           ++  ++ G +PL VA      AL  RA  + LLL+ GA    R+      L LAC++GH 
Sbjct: 737 VNVTSQDGSSPLHVA------ALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHF 790

Query: 98  DAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTA 157
             V+ L+  +  P   D +GN+P+++A + GH  ++  L++     G  ++ +N  G TA
Sbjct: 791 QVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQH----GASINASNNKGNTA 846

Query: 158 LQLAAARGHGTCVQAL 173
           L  A    H   V+ L
Sbjct: 847 LHEAVIEKHVFVVELL 862



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 25/71 (35%), Positives = 37/71 (52%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
           V+ LL+  A  N +D  G T L  AC  GH + V LL+Q      A+++ GN+ +  A  
Sbjct: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVI 852

Query: 127 CGHGAVLEFLV 137
             H  V+E L+
Sbjct: 853 EKHVFVVELLL 863


>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
          Length = 301

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 53/155 (34%), Positives = 77/155 (49%), Gaps = 9/155 (5%)

Query: 19  AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
           A + G + L + +L++  R  +DCR   G T LMVA      A     VR L+ QGA +N
Sbjct: 19  AARRGNLALLKLLLNS-GRVDVDCRDSHGTTLLMVAAY----AGHIDCVRELVLQGADIN 73

Query: 79  LRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVR 138
           L+ E G TAL  A ++GH D V+ L  F    E     G + ++ A+  GH  V+E L++
Sbjct: 74  LQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133

Query: 139 SFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
                G  +      G TAL LAA  G+   ++ L
Sbjct: 134 H----GANIHDQLYDGATALFLAAQGGYLDVIRLL 164



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 46/163 (28%), Positives = 70/163 (42%), Gaps = 10/163 (6%)

Query: 11  AGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLL 70
           +GT     A Q G   + RF+      +  + R + G T L+ A          + V  L
Sbjct: 78  SGTTALFFAAQQGHNDVVRFLFGF--GASTEFRTKDGGTALLAASQYG----HMQVVETL 131

Query: 71  LEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
           L+ GA ++ +   G TAL LA + G+LD ++LL+            G +P+  A+  GH 
Sbjct: 132 LKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHS 191

Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
            V    VR     G   D     G TAL  AA +G+   ++ L
Sbjct: 192 EV----VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKEL 230



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 30/100 (30%), Positives = 53/100 (53%), Gaps = 5/100 (5%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
           +RLLL  GA VN   + G   L +A + GH + V++++    D +AA + G + ++ AA 
Sbjct: 161 IRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAAN 220

Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
            G+  V++ L++    LG+      + G +AL  A   G+
Sbjct: 221 KGYNDVIKELLKFSPTLGIL-----KNGTSALHAAVLSGN 255



 Score = 37.4 bits (85), Expect = 0.023
 Identities = 31/87 (35%), Positives = 44/87 (50%), Gaps = 7/87 (8%)

Query: 91  ACERGHLDAVQLLVQFSG--DPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLD 148
           A  RG+L  ++LL+  SG  D +  DS G + +M AA  GH   +  LV      G  ++
Sbjct: 19  AARRGNLALLKLLLN-SGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQ----GADIN 73

Query: 149 RTNRAGLTALQLAAARGHGTCVQALTG 175
               +G TAL  AA +GH   V+ L G
Sbjct: 74  LQRESGTTALFFAAQQGHNDVVRFLFG 100


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 48/140 (34%), Positives = 68/140 (48%), Gaps = 8/140 (5%)

Query: 46  QGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQ 105
           +G+TPL VA      +L    V+LL  QGA ++ +    RT L LA ERG + A+Q L++
Sbjct: 493 EGKTPLHVAAYFGHVSL----VKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548

Query: 106 FSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARG 165
               P+A D +G  P+  AAA G   + + L+    R G  L+     G T L LAA +G
Sbjct: 549 SGAVPDALDQSGYGPLHTAAARGKYLICKMLL----RYGASLELPTHQGWTPLHLAAYKG 604

Query: 166 HGTCVQALTGPWGRAAAAAA 185
           H   +  L        A  A
Sbjct: 605 HLEIIHLLAESHANMGALGA 624



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 46/163 (28%), Positives = 67/163 (41%), Gaps = 33/163 (20%)

Query: 40  IDCRAEQGRTPLMVAVGLPDPALRARFV-----------------------------RLL 70
           +DC+   G TPL++A     P L A  +                             RLL
Sbjct: 388 VDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLL 447

Query: 71  LEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
           L+ GA V+ ++  G T L LA +    +  +LLV    DP   ++ G +P+  AA  GH 
Sbjct: 448 LDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHV 507

Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
           ++++ L       G  LD   R   T L LA  RG    +Q L
Sbjct: 508 SLVKLLTSQ----GAELDAQQRNLRTPLHLAVERGKVRAIQHL 546



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 42/148 (28%), Positives = 72/148 (48%), Gaps = 14/148 (9%)

Query: 19  AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFV--RLLLEQGAA 76
           A++ GKV   + +L +   ++ D   + G  PL  A      A R +++  ++LL  GA+
Sbjct: 534 AVERGKVRAIQHLLKS--GAVPDALDQSGYGPLHTA------AARGKYLICKMLLRYGAS 585

Query: 77  VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
           + L   +G T L LA  +GHL+ + LL +   +  A  +   +P+  AA  G  AV+  L
Sbjct: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645

Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAAR 164
           +    + G   +   ++G T L LA  R
Sbjct: 646 L----QCGADPNAAEQSGWTPLHLAVQR 669


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
          Length = 2603

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 43/129 (33%), Positives = 66/129 (51%), Gaps = 4/129 (3%)

Query: 10   RAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRL 69
            + G    +EA   G   + R +LD       D  A    +    A+ +       +F  L
Sbjct: 1283 KTGLTPLMEAASGGYAEVGRVLLD----KGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1338

Query: 70   LLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGH 129
            L+ +GA +++R+++G T L LA   GHLD VQLLVQ   D +AAD+   +P+M A   GH
Sbjct: 1339 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1398

Query: 130  GAVLEFLVR 138
              V+ +LV+
Sbjct: 1399 VKVVRYLVK 1407



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 44/128 (34%), Positives = 60/128 (46%), Gaps = 11/128 (8%)

Query: 53  VAVGLPDPALRA------RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
           + +G   P + A        V+ LL  GA V+     G TAL+ ACE GH D   +L+Q 
Sbjct: 560 IELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQA 619

Query: 107 SGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTN-RAGLTALQLAAARG 165
             D E     G +P+M AA  GH   ++FL+      G  ++RT      T L LA A G
Sbjct: 620 GADLEHESEGGRTPLMKAARAGHVCTVQFLISK----GANVNRTTANNDHTVLSLACAGG 675

Query: 166 HGTCVQAL 173
           H   V+ L
Sbjct: 676 HLAVVELL 683



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 48/155 (30%), Positives = 76/155 (49%), Gaps = 8/155 (5%)

Query: 19  AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
           A  AG   LA+ +L A+  ++ D   +   TPLM A          + V+LLL   A VN
Sbjct: 274 ACSAGYYELAQVLL-AMHANVEDRGIKGDITPLMAAAN----GGHVKIVKLLLAHKADVN 328

Query: 79  LRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVR 138
            +   G TAL+ AC  G++D V++L++     E  +  G++P+M A + GH  V   L+ 
Sbjct: 329 AQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLE 388

Query: 139 SFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
           +   +      +N    +AL LA  +GH   V+ L
Sbjct: 389 NGAGIN---THSNEFKESALTLACYKGHLEMVRFL 420



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 49/156 (31%), Positives = 73/156 (46%), Gaps = 11/156 (7%)

Query: 12  GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
           G      A   G V + + +L++   + I+   E G TPLM A      A      RLLL
Sbjct: 334 GNTALTYACAGGYVDVVKVLLES--GASIEDHNENGHTPLMEA----GSAGHVEVARLLL 387

Query: 72  EQGAAVNLR-DERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
           E GA +N   +E   +AL+LAC +GHL+ V+ L++   D E      ++ +M A   GH 
Sbjct: 388 ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447

Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
            V   L+ S  ++ +  D       + L LAA  GH
Sbjct: 448 EVARLLLDSGAQVNMPADSFE----SPLTLAACGGH 479



 Score = 58.5 bits (140), Expect = 9e-09
 Identities = 41/135 (30%), Positives = 72/135 (53%), Gaps = 7/135 (5%)

Query: 40   IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGR-TALSLACERGHLD 98
            I+ R ++G TPL++A      A     V +LL+ GA +  + ER + T LSLAC  G  +
Sbjct: 1109 IEHRDKKGFTPLILAA----TAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQE 1164

Query: 99   AVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTAL 158
             V+LL+    + E  + +  +P+  AA+ G+  +++ L+ +   +  R    ++ G++ L
Sbjct: 1165 VVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTG--SKLGISPL 1222

Query: 159  QLAAARGHGTCVQAL 173
             LAA  GH   V+ L
Sbjct: 1223 MLAAMNGHTAAVKLL 1237



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 12/153 (7%)

Query: 23   GKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDE 82
            G+  +   +LD   ++ ++ RA+ G TPLM A         A   R+LL++GA VN    
Sbjct: 1263 GRTEVVSLLLDR--KANVEHRAKTGLTPLMEAAS----GGYAEVGRVLLDKGADVNAPPV 1316

Query: 83   RGR--TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSF 140
                 TAL++A ++GH    +LL+      +  +  GN+P+  AA  GH  V++ LV++ 
Sbjct: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA- 1375

Query: 141  RRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
               G  +D  +   +T L  A  +GH   V+ L
Sbjct: 1376 ---GADVDAADNRKITPLMAAFRKGHVKVVRYL 1405



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 43/123 (34%), Positives = 62/123 (50%), Gaps = 12/123 (9%)

Query: 45  EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLR-DERGRTALSLACERGHLDAVQLL 103
           ++G TPLM A       +    V LLL QGA +N + +E   TAL+LAC  G L+    L
Sbjct: 498 DEGYTPLMEAAREGHEEM----VALLLGQGANINAQTEETQETALTLACCGGFLEVADFL 553

Query: 104 VQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAA 163
           ++   D E   S   +P+M AA  GH  ++++L+ +    G  +  T   G TAL  A  
Sbjct: 554 IKAGADIELGCS---TPLMEAAQEGHLELVKYLLAA----GANVHATTATGDTALTYACE 606

Query: 164 RGH 166
            GH
Sbjct: 607 NGH 609



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 35/108 (32%), Positives = 59/108 (54%), Gaps = 5/108 (4%)

Query: 67   VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEA-ADSAGNSPVMWAA 125
            V+ LLE+GA++  RD++G T L LA   GH+  V++L+    D EA ++   ++P+  A 
Sbjct: 1099 VQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLAC 1158

Query: 126  ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
            + G   V+E L+      G   +  N +  T L LAA+ G+   ++ L
Sbjct: 1159 SGGRQEVVELLLAR----GANKEHRNVSDYTPLSLAASGGYVNIIKIL 1202



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 48/158 (30%), Positives = 78/158 (49%), Gaps = 7/158 (4%)

Query: 19   AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
            A   G V++ + +L+A         ++ G +PLM+A      A     V+LLL+ G+ +N
Sbjct: 1190 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAA----VKLLLDMGSDIN 1245

Query: 79   LRDERGR-TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLV 137
             + E  R TAL+LAC +G  + V LL+    + E     G +P+M AA+ G+  V   L+
Sbjct: 1246 AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1305

Query: 138  RSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTG 175
                 +      ++R   TAL +AA +GH    + L G
Sbjct: 1306 DKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIG 1341



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 42/127 (33%), Positives = 62/127 (48%), Gaps = 7/127 (5%)

Query: 12  GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
           G      A + G   +A  +L A   + ++  +E GRTPLM A      A     V+ L+
Sbjct: 597 GDTALTYACENGHTDVADVLLQA--GADLEHESEGGRTPLMKAAR----AGHVCTVQFLI 650

Query: 72  EQGAAVNLRDERG-RTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
            +GA VN        T LSLAC  GHL  V+LL+    DP      G++ ++ AA  GH 
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710

Query: 131 AVLEFLV 137
           +V+ +L+
Sbjct: 711 SVVCYLL 717



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 41/147 (27%), Positives = 68/147 (46%), Gaps = 9/147 (6%)

Query: 19  AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
           A   G + + RF+L+A   +  + + ++  T LM A             RLLL+ GA VN
Sbjct: 408 ACYKGHLEMVRFLLEA--GADQEHKTDEMHTALMEAC----MDGHVEVARLLLDSGAQVN 461

Query: 79  LRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVR 138
           +  +   + L+LA   GH++   LL++     E  +  G +P+M AA  GH  ++  L+ 
Sbjct: 462 MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG 521

Query: 139 SFRRLGLRLDRTNRAGLTALQLAAARG 165
               +  + + T     TAL LA   G
Sbjct: 522 QGANINAQTEETQE---TALTLACCGG 545



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 35/107 (32%), Positives = 52/107 (48%), Gaps = 14/107 (13%)

Query: 86   TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGL 145
            TAL+LAC  GH + VQ L++     E  D  G +P++ AA  GH  V+E L+ +   +  
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 146  RLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSD 192
            + +RT     T L LA + G    V+ L            ARG+N +
Sbjct: 1145 QSERTKD---TPLSLACSGGRQEVVELL-----------LARGANKE 1177



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 34/108 (31%), Positives = 54/108 (50%), Gaps = 5/108 (4%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGN-SPVMWAA 125
           VR LL +G +VN   E G + L LAC  G+ +  Q+L+    + E     G+ +P+M AA
Sbjct: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309

Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
             GH  +++ L+         ++  +  G TAL  A A G+   V+ L
Sbjct: 310 NGGHVKIVKLLLAH----KADVNAQSSTGNTALTYACAGGYVDVVKVL 353


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 43/129 (33%), Positives = 66/129 (51%), Gaps = 4/129 (3%)

Query: 10   RAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRL 69
            + G    +EA   G   + R +LD       D  A    +    A+ +       +F  L
Sbjct: 1032 KTGLTPLMEAASGGYAEVGRVLLD----KGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1087

Query: 70   LLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGH 129
            L+ +GA +++R+++G T L LA   GHLD VQLLVQ   D +AAD+   +P+M A   GH
Sbjct: 1088 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1147

Query: 130  GAVLEFLVR 138
              V+ +LV+
Sbjct: 1148 VKVVRYLVK 1156



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 44/128 (34%), Positives = 60/128 (46%), Gaps = 11/128 (8%)

Query: 53  VAVGLPDPALRA------RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
           + +G   P + A        V+ LL  GA V+     G TAL+ ACE GH D   +L+Q 
Sbjct: 560 IELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQA 619

Query: 107 SGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTN-RAGLTALQLAAARG 165
             D E     G +P+M AA  GH   ++FL+      G  ++RT      T L LA A G
Sbjct: 620 GADLEHESEGGRTPLMKAARAGHVCTVQFLISK----GANVNRTTANNDHTVLSLACAGG 675

Query: 166 HGTCVQAL 173
           H   V+ L
Sbjct: 676 HLAVVELL 683



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 48/155 (30%), Positives = 76/155 (49%), Gaps = 8/155 (5%)

Query: 19  AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
           A  AG   LA+ +L A+  ++ D   +   TPLM A          + V+LLL   A VN
Sbjct: 274 ACSAGYYELAQVLL-AMHANVEDRGIKGDITPLMAAAN----GGHVKIVKLLLAHKADVN 328

Query: 79  LRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVR 138
            +   G TAL+ AC  G++D V++L++     E  +  G++P+M A + GH  V   L+ 
Sbjct: 329 AQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLE 388

Query: 139 SFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
           +   +      +N    +AL LA  +GH   V+ L
Sbjct: 389 NGAGIN---THSNEFKESALTLACYKGHLEMVRFL 420



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 49/156 (31%), Positives = 73/156 (46%), Gaps = 11/156 (7%)

Query: 12  GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
           G      A   G V + + +L++   + I+   E G TPLM A      A      RLLL
Sbjct: 334 GNTALTYACAGGYVDVVKVLLES--GASIEDHNENGHTPLMEA----GSAGHVEVARLLL 387

Query: 72  EQGAAVNLR-DERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
           E GA +N   +E   +AL+LAC +GHL+ V+ L++   D E      ++ +M A   GH 
Sbjct: 388 ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447

Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
            V   L+ S  ++ +  D       + L LAA  GH
Sbjct: 448 EVARLLLDSGAQVNMPADSFE----SPLTLAACGGH 479



 Score = 58.5 bits (140), Expect = 9e-09
 Identities = 41/135 (30%), Positives = 72/135 (53%), Gaps = 7/135 (5%)

Query: 40  IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGR-TALSLACERGHLD 98
           I+ R ++G TPL++A      A     V +LL+ GA +  + ER + T LSLAC  G  +
Sbjct: 858 IEHRDKKGFTPLILAA----TAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQE 913

Query: 99  AVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTAL 158
            V+LL+    + E  + +  +P+  AA+ G+  +++ L+ +   +  R    ++ G++ L
Sbjct: 914 VVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTG--SKLGISPL 971

Query: 159 QLAAARGHGTCVQAL 173
            LAA  GH   V+ L
Sbjct: 972 MLAAMNGHTAAVKLL 986



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 12/153 (7%)

Query: 23   GKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDE 82
            G+  +   +LD   ++ ++ RA+ G TPLM A         A   R+LL++GA VN    
Sbjct: 1012 GRTEVVSLLLDR--KANVEHRAKTGLTPLMEAAS----GGYAEVGRVLLDKGADVNAPPV 1065

Query: 83   RGR--TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSF 140
                 TAL++A ++GH    +LL+      +  +  GN+P+  AA  GH  V++ LV++ 
Sbjct: 1066 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA- 1124

Query: 141  RRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
               G  +D  +   +T L  A  +GH   V+ L
Sbjct: 1125 ---GADVDAADNRKITPLMAAFRKGHVKVVRYL 1154



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 43/123 (34%), Positives = 62/123 (50%), Gaps = 12/123 (9%)

Query: 45  EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLR-DERGRTALSLACERGHLDAVQLL 103
           ++G TPLM A       +    V LLL QGA +N + +E   TAL+LAC  G L+    L
Sbjct: 498 DEGYTPLMEAAREGHEEM----VALLLGQGANINAQTEETQETALTLACCGGFLEVADFL 553

Query: 104 VQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAA 163
           ++   D E   S   +P+M AA  GH  ++++L+ +    G  +  T   G TAL  A  
Sbjct: 554 IKAGADIELGCS---TPLMEAAQEGHLELVKYLLAA----GANVHATTATGDTALTYACE 606

Query: 164 RGH 166
            GH
Sbjct: 607 NGH 609



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 35/108 (32%), Positives = 59/108 (54%), Gaps = 5/108 (4%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEA-ADSAGNSPVMWAA 125
           V+ LLE+GA++  RD++G T L LA   GH+  V++L+    D EA ++   ++P+  A 
Sbjct: 848 VQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLAC 907

Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
           + G   V+E L+      G   +  N +  T L LAA+ G+   ++ L
Sbjct: 908 SGGRQEVVELLLAR----GANKEHRNVSDYTPLSLAASGGYVNIIKIL 951



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 48/158 (30%), Positives = 78/158 (49%), Gaps = 7/158 (4%)

Query: 19   AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
            A   G V++ + +L+A         ++ G +PLM+A      A     V+LLL+ G+ +N
Sbjct: 939  AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAA----VKLLLDMGSDIN 994

Query: 79   LRDERGR-TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLV 137
             + E  R TAL+LAC +G  + V LL+    + E     G +P+M AA+ G+  V   L+
Sbjct: 995  AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1054

Query: 138  RSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTG 175
                 +      ++R   TAL +AA +GH    + L G
Sbjct: 1055 DKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIG 1090



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 42/127 (33%), Positives = 62/127 (48%), Gaps = 7/127 (5%)

Query: 12  GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
           G      A + G   +A  +L A   + ++  +E GRTPLM A      A     V+ L+
Sbjct: 597 GDTALTYACENGHTDVADVLLQA--GADLEHESEGGRTPLMKAAR----AGHVCTVQFLI 650

Query: 72  EQGAAVNLRDERG-RTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
            +GA VN        T LSLAC  GHL  V+LL+    DP      G++ ++ AA  GH 
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710

Query: 131 AVLEFLV 137
           +V+ +L+
Sbjct: 711 SVVCYLL 717



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 41/147 (27%), Positives = 68/147 (46%), Gaps = 9/147 (6%)

Query: 19  AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
           A   G + + RF+L+A   +  + + ++  T LM A             RLLL+ GA VN
Sbjct: 408 ACYKGHLEMVRFLLEA--GADQEHKTDEMHTALMEAC----MDGHVEVARLLLDSGAQVN 461

Query: 79  LRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVR 138
           +  +   + L+LA   GH++   LL++     E  +  G +P+M AA  GH  ++  L+ 
Sbjct: 462 MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG 521

Query: 139 SFRRLGLRLDRTNRAGLTALQLAAARG 165
               +  + + T     TAL LA   G
Sbjct: 522 QGANINAQTEETQE---TALTLACCGG 545



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 35/107 (32%), Positives = 52/107 (48%), Gaps = 14/107 (13%)

Query: 86  TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGL 145
           TAL+LAC  GH + VQ L++     E  D  G +P++ AA  GH  V+E L+ +   +  
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893

Query: 146 RLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSD 192
           + +RT     T L LA + G    V+ L            ARG+N +
Sbjct: 894 QSERTKD---TPLSLACSGGRQEVVELL-----------LARGANKE 926



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 34/108 (31%), Positives = 54/108 (50%), Gaps = 5/108 (4%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGN-SPVMWAA 125
           VR LL +G +VN   E G + L LAC  G+ +  Q+L+    + E     G+ +P+M AA
Sbjct: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309

Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
             GH  +++ L+         ++  +  G TAL  A A G+   V+ L
Sbjct: 310 NGGHVKIVKLLLAH----KADVNAQSSTGNTALTYACAGGYVDVVKVL 353


>gi|169167742 PREDICTED: ankyrin repeat domain 33B [Homo sapiens]
          Length = 494

 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 86/315 (27%), Positives = 124/315 (39%), Gaps = 28/315 (8%)

Query: 67  VRLLLEQGAAVNLR---DERGRTALSLACERGHLDAVQLLVQFSG-DPEAADSAGNSPVM 122
           +R L+ +G +V      D  GRT L +AC  G +D V  L +    D    DS GN+ ++
Sbjct: 101 LRTLVRRGVSVEEAQETDRNGRTGLIVACYHGFVDTVVALAECPHVDVNWQDSEGNTALI 160

Query: 123 WAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAA 182
            AA  GH  +  +L+  F   GL L+R N  G TAL  AA +G   C++AL        A
Sbjct: 161 TAAQAGHAIITNYLLNYFP--GLDLERRNAFGFTALMKAAMQGRTDCIRALMLAGADVHA 218

Query: 183 AAAARGSNSD---SPPGRPAPAASPEH--RRPSPRRL---PRPLLARFARAAGGHGGEAG 234
               RG +     +  GR       +    RP P +     RP L     AA    G   
Sbjct: 219 RDPRRGMSPQEWATYTGRVDAVRLMQRLLERPCPEQFWEKYRPELPPPPEAARKPAGSKN 278

Query: 235 SAGKNSGRHRAQGSER----PELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTG 290
              + +    +  + R    PE G  +   +   T   +  +        P SP S G  
Sbjct: 279 CLQRLTDCVLSVLTPRSVRGPEDGGVLDHMVRMTTSLYSPAVAIVCQTVCPESPPSVGKR 338

Query: 291 RWRSQEVLEGAPPTLAQAPIGLSPHPEGGPGS-GRLG-----LRRRSTAPDIPSLVGEAP 344
           R   QE+L       A+ P        GG G  GR G      R  S    +P  +G + 
Sbjct: 339 RLAVQEILAA---RAARGPQAQEEDEVGGAGQRGRTGQEDADSREGSPRAGLPPALG-SR 394

Query: 345 GPESGPELEANALPV 359
           GP +    +A+ LP+
Sbjct: 395 GPAAPAPRKASLLPL 409


>gi|113416996 PREDICTED: ankyrin repeat domain 33B [Homo sapiens]
          Length = 1006

 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 86/315 (27%), Positives = 124/315 (39%), Gaps = 28/315 (8%)

Query: 67  VRLLLEQGAAVNLR---DERGRTALSLACERGHLDAVQLLVQFSG-DPEAADSAGNSPVM 122
           +R L+ +G +V      D  GRT L +AC  G +D V  L +    D    DS GN+ ++
Sbjct: 613 LRTLVRRGVSVEEAQETDRNGRTGLIVACYHGFVDTVVALAECPHVDVNWQDSEGNTALI 672

Query: 123 WAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAA 182
            AA  GH  +  +L+  F   GL L+R N  G TAL  AA +G   C++AL        A
Sbjct: 673 TAAQAGHAIITNYLLNYFP--GLDLERRNAFGFTALMKAAMQGRTDCIRALMLAGADVHA 730

Query: 183 AAAARGSNSD---SPPGRPAPAASPEH--RRPSPRRL---PRPLLARFARAAGGHGGEAG 234
               RG +     +  GR       +    RP P +     RP L     AA    G   
Sbjct: 731 RDPRRGMSPQEWATYTGRVDAVRLMQRLLERPCPEQFWEKYRPELPPPPEAARKPAGSKN 790

Query: 235 SAGKNSGRHRAQGSER----PELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTG 290
              + +    +  + R    PE G  +   +   T   +  +        P SP S G  
Sbjct: 791 CLQRLTDCVLSVLTPRSVRGPEDGGVLDHMVRMTTSLYSPAVAIVCQTVCPESPPSVGKR 850

Query: 291 RWRSQEVLEGAPPTLAQAPIGLSPHPEGGPGS-GRLG-----LRRRSTAPDIPSLVGEAP 344
           R   QE+L       A+ P        GG G  GR G      R  S    +P  +G + 
Sbjct: 851 RLAVQEILAA---RAARGPQAQEEDEVGGAGQRGRTGQEDADSREGSPRAGLPPALG-SR 906

Query: 345 GPESGPELEANALPV 359
           GP +    +A+ LP+
Sbjct: 907 GPAAPAPRKASLLPL 921



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 56/187 (29%), Positives = 74/187 (39%), Gaps = 31/187 (16%)

Query: 178 GRAAAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAG----GHGGEA 233
           GR   +A  R    D PP     A+ PE +    + L RP   R + A G    G G   
Sbjct: 187 GRERTSAPLR---RDLPPRLAHDASYPEVKGSLWQILTRPPPPRPSPAPGLTGRGQGRAR 243

Query: 234 GSAGKNSG-RHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRW 292
           G+ G + G R R     +P++G + S +L   +     R R      +P S Q S  GR 
Sbjct: 244 GAVGLDCGCRPRPCSFGQPDVGSAPSRSLRGCS----LRFR-NTPPPIPGSDQPSSHGRP 298

Query: 293 RSQEVLE---------GAPPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEA 343
           R +E  +         G PP    AP    P P+  PG+G      R TAP    L   A
Sbjct: 299 RFRETGDSEDCPPFRAGTPPQQPTAPSSEWPGPQRSPGTG-----PRWTAP----LPRPA 349

Query: 344 PGPESGP 350
           P P   P
Sbjct: 350 PLPAKRP 356


>gi|239742483 PREDICTED: ankyrin repeat domain 33B [Homo sapiens]
          Length = 494

 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 86/315 (27%), Positives = 124/315 (39%), Gaps = 28/315 (8%)

Query: 67  VRLLLEQGAAVNLR---DERGRTALSLACERGHLDAVQLLVQFSG-DPEAADSAGNSPVM 122
           +R L+ +G +V      D  GRT L +AC  G +D V  L +    D    DS GN+ ++
Sbjct: 101 LRTLVRRGVSVEEAQETDRNGRTGLIVACYHGFVDTVVALAECPHVDVNWQDSEGNTALI 160

Query: 123 WAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAA 182
            AA  GH  +  +L+  F   GL L+R N  G TAL  AA +G   C++AL        A
Sbjct: 161 TAAQAGHAIITNYLLNYFP--GLDLERRNAFGFTALMKAAMQGRTDCIRALMLAGADVHA 218

Query: 183 AAAARGSNSD---SPPGRPAPAASPEH--RRPSPRRL---PRPLLARFARAAGGHGGEAG 234
               RG +     +  GR       +    RP P +     RP L     AA    G   
Sbjct: 219 RDPRRGMSPQEWATYTGRVDAVRLMQRLLERPCPEQFWEKYRPELPPPPEAARKPAGSKN 278

Query: 235 SAGKNSGRHRAQGSER----PELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTG 290
              + +    +  + R    PE G  +   +   T   +  +        P SP S G  
Sbjct: 279 CLQRLTDCVLSVLTPRSVRGPEDGGVLDHMVRMTTSLYSPAVAIVCQTVCPESPPSVGKR 338

Query: 291 RWRSQEVLEGAPPTLAQAPIGLSPHPEGGPGS-GRLG-----LRRRSTAPDIPSLVGEAP 344
           R   QE+L       A+ P        GG G  GR G      R  S    +P  +G + 
Sbjct: 339 RLAVQEILAA---RAARGPQAQEEDEVGGAGQRGRTGQEDADSREGSPRAGLPPALG-SR 394

Query: 345 GPESGPELEANALPV 359
           GP +    +A+ LP+
Sbjct: 395 GPAAPAPRKASLLPL 409


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 2542

 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 42/129 (32%), Positives = 66/129 (51%), Gaps = 4/129 (3%)

Query: 10   RAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRL 69
            + G    +EA   G   + R +LD       D  A    +    A+ +       +F  L
Sbjct: 1255 KTGLTPLMEAASGGYAEVGRVLLD----KGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1310

Query: 70   LLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGH 129
            L+ +GA +++R+++G T L LA   GH D VQLLVQ   D +AAD+   +P+M A   GH
Sbjct: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGH 1370

Query: 130  GAVLEFLVR 138
              V+++LV+
Sbjct: 1371 VKVVQYLVK 1379



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 43/128 (33%), Positives = 60/128 (46%), Gaps = 11/128 (8%)

Query: 53  VAVGLPDPALRA------RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
           + +G   P + A        V+ LL  GA V+     G TAL+ ACE GH D   +L+Q 
Sbjct: 531 IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 590

Query: 107 SGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDR-TNRAGLTALQLAAARG 165
             D E     G +P+M AA  GH   ++FL+      G  ++R T     T + LA A G
Sbjct: 591 GADLEHESEGGRTPLMKAARAGHLCTVQFLISK----GANVNRATANNDHTVVSLACAGG 646

Query: 166 HGTCVQAL 173
           H   V+ L
Sbjct: 647 HLAVVELL 654



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 48/156 (30%), Positives = 73/156 (46%), Gaps = 11/156 (7%)

Query: 12  GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
           G      A   G V + + +L+  + + I+   E G TPLM A      A      R+LL
Sbjct: 305 GNTALTYACAGGFVDIVKVLLN--EGANIEDHNENGHTPLMEAAS----AGHVEVARVLL 358

Query: 72  EQGAAVNLR-DERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
           + GA +N   +E   +AL+LAC +GHLD V+ L++   D E      ++ +M A   GH 
Sbjct: 359 DHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418

Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
            V   L+ S  ++ +  D       + L LAA  GH
Sbjct: 419 EVARLLLDSGAQVNMPADSFE----SPLTLAACGGH 450



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 12/153 (7%)

Query: 23   GKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDE 82
            G+  +   +LD   ++ ++ RA+ G TPLM A         A   R+LL++GA VN    
Sbjct: 1235 GRAEVVSLLLDR--KANVEHRAKTGLTPLMEAAS----GGYAEVGRVLLDKGADVNAPPV 1288

Query: 83   RGR--TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSF 140
                 TAL++A ++GH    +LL+      +  +  GN+P+  A+  GH  V++ LV++ 
Sbjct: 1289 PSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA- 1347

Query: 141  RRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
               G  +D  +   +T L  A  +GH   VQ L
Sbjct: 1348 ---GADVDAADNRKITPLMSAFRKGHVKVVQYL 1377



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 51/157 (32%), Positives = 76/157 (48%), Gaps = 12/157 (7%)

Query: 19  AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAV--GLPDPALRARFVRLLLEQGAA 76
           A  AG   LA+ +L A+  ++ D   +   TPLM A   G  D       V+LLL   A 
Sbjct: 245 ACSAGYYELAQVLL-AMHANVEDRGNKGDITPLMAASSGGYLD------IVKLLLLHDAD 297

Query: 77  VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
           VN +   G TAL+ AC  G +D V++L+    + E  +  G++P+M AA+ GH  V   L
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 357

Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
           +     +      +N    +AL LA  +GH   V+ L
Sbjct: 358 LDHGAGIN---THSNEFKESALTLACYKGHLDMVRFL 391



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 40/135 (29%), Positives = 71/135 (52%), Gaps = 7/135 (5%)

Query: 40   IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGR-TALSLACERGHLD 98
            I+ R ++G TPL++A      A     V +LL++G  +  + ER + T LSLAC  G  +
Sbjct: 1081 IEHRDKKGFTPLILAA----TAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 1136

Query: 99   AVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTAL 158
             V LL+    + E  + +  +P+  AA+ G+  +++ L+ +   +  R    ++ G++ L
Sbjct: 1137 VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTG--SKLGISPL 1194

Query: 159  QLAAARGHGTCVQAL 173
             LAA  GH   V+ L
Sbjct: 1195 MLAAMNGHVPAVKLL 1209



 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 42/123 (34%), Positives = 61/123 (49%), Gaps = 12/123 (9%)

Query: 45  EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLR-DERGRTALSLACERGHLDAVQLL 103
           ++G TPLM A       +    V LLL QGA +N + +E   TAL+LAC  G  +    L
Sbjct: 469 DEGYTPLMEAAREGHEEM----VALLLAQGANINAQTEETQETALTLACCGGFSEVADFL 524

Query: 104 VQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAA 163
           ++   D E   S   +P+M A+  GH  ++++L+ S    G  +  T   G TAL  A  
Sbjct: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLAS----GANVHATTATGDTALTYACE 577

Query: 164 RGH 166
            GH
Sbjct: 578 NGH 580



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 46/151 (30%), Positives = 76/151 (50%), Gaps = 11/151 (7%)

Query: 19   AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARF--VRLLLEQGAA 76
            A   G V++ + +L+A         ++ G +PLM+A      A+      V+LLL+ G+ 
Sbjct: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA------AMNGHVPAVKLLLDMGSD 1215

Query: 77   VNLRDERGR-TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEF 135
            +N + E  R TAL+LAC +G  + V LL+    + E     G +P+M AA+ G+  V   
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275

Query: 136  LVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
            L+     +      ++R   TAL +AA +GH
Sbjct: 1276 LLDKGADVNAPPVPSSRD--TALTIAADKGH 1304



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 45/182 (24%), Positives = 75/182 (41%), Gaps = 31/182 (17%)

Query: 12  GTRTFLEAMQAGKVHLARFVLDA--------------------------LDRSIIDCRAE 45
           G    +EA  AG V +AR +LD                           + R +++  A+
Sbjct: 338 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGAD 397

Query: 46  QGRTPLMVAVGLPDPAL--RARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLL 103
           Q      +   L +  +       RLLL+ GA VN+  +   + L+LA   GH++   LL
Sbjct: 398 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457

Query: 104 VQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAA 163
           ++   + E  +  G +P+M AA  GH  ++  L+     +  + + T     TAL LA  
Sbjct: 458 IERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE---TALTLACC 514

Query: 164 RG 165
            G
Sbjct: 515 GG 516



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 41/127 (32%), Positives = 61/127 (48%), Gaps = 7/127 (5%)

Query: 12  GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
           G      A + G   +A  +L A   + ++  +E GRTPLM A      A     V+ L+
Sbjct: 568 GDTALTYACENGHTDVADVLLQA--GADLEHESEGGRTPLMKAAR----AGHLCTVQFLI 621

Query: 72  EQGAAVNLRDERG-RTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
            +GA VN        T +SLAC  GHL  V+LL+    DP      G++ ++ AA  GH 
Sbjct: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681

Query: 131 AVLEFLV 137
            V+ +L+
Sbjct: 682 NVVSYLL 688



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 32/108 (29%), Positives = 57/108 (52%), Gaps = 5/108 (4%)

Query: 67   VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEA-ADSAGNSPVMWAA 125
            V +L+ + A +  RD++G T L LA   GH+  V++L+   GD EA ++   ++P+  A 
Sbjct: 1071 VSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130

Query: 126  ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
            + G   V++ L+      G   +  N +  T L LAA+ G+   ++ L
Sbjct: 1131 SGGRQEVVDLLLAR----GANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 32/108 (29%), Positives = 56/108 (51%), Gaps = 5/108 (4%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGN-SPVMWAA 125
           VR LL++G +VN   E G + L LAC  G+ +  Q+L+    + E   + G+ +P+M A+
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280

Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
           + G+  +++ L+         ++  +  G TAL  A A G    V+ L
Sbjct: 281 SGGYLDIVKLLLLH----DADVNSQSATGNTALTYACAGGFVDIVKVL 324



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 14/107 (13%)

Query: 86   TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGL 145
            TAL+LAC  GH + V +L+      E  D  G +P++ AA  GH  V+E L+     +  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 146  RLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSD 192
            + +RT     T L LA + G    V  L            ARG+N +
Sbjct: 1117 QSERTKD---TPLSLACSGGRQEVVDLL-----------LARGANKE 1149


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 42/129 (32%), Positives = 66/129 (51%), Gaps = 4/129 (3%)

Query: 10   RAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRL 69
            + G    +EA   G   + R +LD       D  A    +    A+ +       +F  L
Sbjct: 1255 KTGLTPLMEAASGGYAEVGRVLLD----KGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1310

Query: 70   LLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGH 129
            L+ +GA +++R+++G T L LA   GH D VQLLVQ   D +AAD+   +P+M A   GH
Sbjct: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGH 1370

Query: 130  GAVLEFLVR 138
              V+++LV+
Sbjct: 1371 VKVVQYLVK 1379



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 43/128 (33%), Positives = 60/128 (46%), Gaps = 11/128 (8%)

Query: 53  VAVGLPDPALRA------RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
           + +G   P + A        V+ LL  GA V+     G TAL+ ACE GH D   +L+Q 
Sbjct: 531 IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 590

Query: 107 SGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDR-TNRAGLTALQLAAARG 165
             D E     G +P+M AA  GH   ++FL+      G  ++R T     T + LA A G
Sbjct: 591 GADLEHESEGGRTPLMKAARAGHLCTVQFLISK----GANVNRATANNDHTVVSLACAGG 646

Query: 166 HGTCVQAL 173
           H   V+ L
Sbjct: 647 HLAVVELL 654



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 48/156 (30%), Positives = 73/156 (46%), Gaps = 11/156 (7%)

Query: 12  GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
           G      A   G V + + +L+  + + I+   E G TPLM A      A      R+LL
Sbjct: 305 GNTALTYACAGGFVDIVKVLLN--EGANIEDHNENGHTPLMEAAS----AGHVEVARVLL 358

Query: 72  EQGAAVNLR-DERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
           + GA +N   +E   +AL+LAC +GHLD V+ L++   D E      ++ +M A   GH 
Sbjct: 359 DHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418

Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
            V   L+ S  ++ +  D       + L LAA  GH
Sbjct: 419 EVARLLLDSGAQVNMPADSFE----SPLTLAACGGH 450



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 12/153 (7%)

Query: 23   GKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDE 82
            G+  +   +LD   ++ ++ RA+ G TPLM A         A   R+LL++GA VN    
Sbjct: 1235 GRAEVVSLLLDR--KANVEHRAKTGLTPLMEAAS----GGYAEVGRVLLDKGADVNAPPV 1288

Query: 83   RGR--TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSF 140
                 TAL++A ++GH    +LL+      +  +  GN+P+  A+  GH  V++ LV++ 
Sbjct: 1289 PSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA- 1347

Query: 141  RRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
               G  +D  +   +T L  A  +GH   VQ L
Sbjct: 1348 ---GADVDAADNRKITPLMSAFRKGHVKVVQYL 1377



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 51/157 (32%), Positives = 76/157 (48%), Gaps = 12/157 (7%)

Query: 19  AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAV--GLPDPALRARFVRLLLEQGAA 76
           A  AG   LA+ +L A+  ++ D   +   TPLM A   G  D       V+LLL   A 
Sbjct: 245 ACSAGYYELAQVLL-AMHANVEDRGNKGDITPLMAASSGGYLD------IVKLLLLHDAD 297

Query: 77  VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
           VN +   G TAL+ AC  G +D V++L+    + E  +  G++P+M AA+ GH  V   L
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 357

Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
           +     +      +N    +AL LA  +GH   V+ L
Sbjct: 358 LDHGAGIN---THSNEFKESALTLACYKGHLDMVRFL 391



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 40/135 (29%), Positives = 71/135 (52%), Gaps = 7/135 (5%)

Query: 40   IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGR-TALSLACERGHLD 98
            I+ R ++G TPL++A      A     V +LL++G  +  + ER + T LSLAC  G  +
Sbjct: 1081 IEHRDKKGFTPLILAA----TAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 1136

Query: 99   AVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTAL 158
             V LL+    + E  + +  +P+  AA+ G+  +++ L+ +   +  R    ++ G++ L
Sbjct: 1137 VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTG--SKLGISPL 1194

Query: 159  QLAAARGHGTCVQAL 173
             LAA  GH   V+ L
Sbjct: 1195 MLAAMNGHVPAVKLL 1209



 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 42/123 (34%), Positives = 61/123 (49%), Gaps = 12/123 (9%)

Query: 45  EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLR-DERGRTALSLACERGHLDAVQLL 103
           ++G TPLM A       +    V LLL QGA +N + +E   TAL+LAC  G  +    L
Sbjct: 469 DEGYTPLMEAAREGHEEM----VALLLAQGANINAQTEETQETALTLACCGGFSEVADFL 524

Query: 104 VQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAA 163
           ++   D E   S   +P+M A+  GH  ++++L+ S    G  +  T   G TAL  A  
Sbjct: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLAS----GANVHATTATGDTALTYACE 577

Query: 164 RGH 166
            GH
Sbjct: 578 NGH 580



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 46/151 (30%), Positives = 76/151 (50%), Gaps = 11/151 (7%)

Query: 19   AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARF--VRLLLEQGAA 76
            A   G V++ + +L+A         ++ G +PLM+A      A+      V+LLL+ G+ 
Sbjct: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA------AMNGHVPAVKLLLDMGSD 1215

Query: 77   VNLRDERGR-TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEF 135
            +N + E  R TAL+LAC +G  + V LL+    + E     G +P+M AA+ G+  V   
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275

Query: 136  LVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
            L+     +      ++R   TAL +AA +GH
Sbjct: 1276 LLDKGADVNAPPVPSSRD--TALTIAADKGH 1304



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 45/182 (24%), Positives = 75/182 (41%), Gaps = 31/182 (17%)

Query: 12  GTRTFLEAMQAGKVHLARFVLDA--------------------------LDRSIIDCRAE 45
           G    +EA  AG V +AR +LD                           + R +++  A+
Sbjct: 338 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGAD 397

Query: 46  QGRTPLMVAVGLPDPAL--RARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLL 103
           Q      +   L +  +       RLLL+ GA VN+  +   + L+LA   GH++   LL
Sbjct: 398 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457

Query: 104 VQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAA 163
           ++   + E  +  G +P+M AA  GH  ++  L+     +  + + T     TAL LA  
Sbjct: 458 IERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE---TALTLACC 514

Query: 164 RG 165
            G
Sbjct: 515 GG 516



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 41/127 (32%), Positives = 61/127 (48%), Gaps = 7/127 (5%)

Query: 12  GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
           G      A + G   +A  +L A   + ++  +E GRTPLM A      A     V+ L+
Sbjct: 568 GDTALTYACENGHTDVADVLLQA--GADLEHESEGGRTPLMKAAR----AGHLCTVQFLI 621

Query: 72  EQGAAVNLRDERG-RTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
            +GA VN        T +SLAC  GHL  V+LL+    DP      G++ ++ AA  GH 
Sbjct: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681

Query: 131 AVLEFLV 137
            V+ +L+
Sbjct: 682 NVVSYLL 688



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 32/108 (29%), Positives = 57/108 (52%), Gaps = 5/108 (4%)

Query: 67   VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEA-ADSAGNSPVMWAA 125
            V +L+ + A +  RD++G T L LA   GH+  V++L+   GD EA ++   ++P+  A 
Sbjct: 1071 VSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130

Query: 126  ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
            + G   V++ L+      G   +  N +  T L LAA+ G+   ++ L
Sbjct: 1131 SGGRQEVVDLLLAR----GANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 32/108 (29%), Positives = 56/108 (51%), Gaps = 5/108 (4%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGN-SPVMWAA 125
           VR LL++G +VN   E G + L LAC  G+ +  Q+L+    + E   + G+ +P+M A+
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280

Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
           + G+  +++ L+         ++  +  G TAL  A A G    V+ L
Sbjct: 281 SGGYLDIVKLLLLH----DADVNSQSATGNTALTYACAGGFVDIVKVL 324



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 14/107 (13%)

Query: 86   TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGL 145
            TAL+LAC  GH + V +L+      E  D  G +P++ AA  GH  V+E L+     +  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 146  RLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSD 192
            + +RT     T L LA + G    V  L            ARG+N +
Sbjct: 1117 QSERTKD---TPLSLACSGGRQEVVDLL-----------LARGANKE 1149


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 93/329 (28%), Positives = 125/329 (37%), Gaps = 33/329 (10%)

Query: 10   RAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRL 69
            RAG RT L A  A        +L    ++ +D R E G TPLM+A  L    L    V  
Sbjct: 1665 RAG-RTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDL----VEE 1719

Query: 70   LLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGH 129
            L+   A V  RD+ G+TAL  A    +  A + L+Q   D +A D+   +P+  AA  G 
Sbjct: 1720 LIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGA 1779

Query: 130  GAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGS 189
              V + L+     LG   +  ++AGL    +A  R H   +  L G     A   A  G 
Sbjct: 1780 VEVAQLLL----GLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPGR 1835

Query: 190  NSDS-PPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKN-SGRHRAQG 247
             +   P  R    + P H       LPR      +  AG  GG A    +  S    A+G
Sbjct: 1836 EAGPFPRARTVSVSVPPH---GGGALPR--CRTLSAGAGPRGGGACLQARTWSVDLAARG 1890

Query: 248  SERPELGRSMS-LALGAVTEEEAARLRAGALMALPNSPQSSG-------------TGRWR 293
                   RS+S +  G        R  AG     PN     G             T  W 
Sbjct: 1891 GGAYSHCRSLSGVGAGGGPTPRGRRFSAGMRGPRPNPAIMRGRYGVAAGRGGRVSTDDWP 1950

Query: 294  SQEVLEGAPPTLAQAPIG---LSPHPEGG 319
               V  GA  + +  PI    L+P PE G
Sbjct: 1951 CDWVALGACGSASNIPIPPPCLTPSPERG 1979



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 44/149 (29%), Positives = 65/149 (43%), Gaps = 13/149 (8%)

Query: 47   GRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
            G TPL +A     P    R    LLE GA  N  D  GRT L  A      +  QLL++ 
Sbjct: 1634 GETPLHLAARFSRPTAARR----LLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRS 1689

Query: 107  SGDP-EAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARG 165
                 +A    G +P+M AA      ++E L+ +   +G R    ++ G TAL  AAA  
Sbjct: 1690 RQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGAR----DKWGKTALHWAAAVN 1745

Query: 166  HGTCVQALTGPWGRAAAAAAARGSNSDSP 194
            +    ++L     +A A   A+ +   +P
Sbjct: 1746 NARAARSLL----QAGADKDAQDNREQTP 1770


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 46/157 (29%), Positives = 77/157 (49%), Gaps = 14/157 (8%)

Query: 23  GKVHLARFVLDALDRSIIDCRAEQGRTPLMVAV--GLPDPALRARFVRLLLEQGAAVNLR 80
           G   L   +L+A  ++ +D +  +G  PL  A   G  +P      ++L+L+ G+AVN+ 
Sbjct: 60  GNTELISLLLEA--QAAVDIKDNKGMRPLHYAAWQGRKEP------MKLVLKAGSAVNIP 111

Query: 81  DERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSF 140
            + G   L LA + GH D  ++L+Q   +P   D++G +P+  A   G   V++ L+ S 
Sbjct: 112 SDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSN 171

Query: 141 RRLGLRL----DRTNRAGLTALQLAAARGHGTCVQAL 173
               L      D T+  G + L LAA  GH   ++ L
Sbjct: 172 MCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLL 208


>gi|110431370 espin [Homo sapiens]
          Length = 854

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 47/125 (37%), Positives = 64/125 (51%), Gaps = 11/125 (8%)

Query: 45  EQGRTPLMVAVGLPD-PALRARFVRLLLEQ-GAAVNLRDERGRTALSLACERGHLDAVQL 102
           + G  P+  A    D P+LR     LL+E     VN + + G T L LAC+ GHL+  Q 
Sbjct: 136 DMGALPIHYAAAKGDFPSLR-----LLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQY 190

Query: 103 LVQFSG-DPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLA 161
           LVQ  G DP A    G +P+  AA  GH  V+ +LV       + L   ++ G TA+  A
Sbjct: 191 LVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSC---TDVSLSEQDKDGATAMHFA 247

Query: 162 AARGH 166
           A+RGH
Sbjct: 248 ASRGH 252



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 60/174 (34%), Positives = 75/174 (43%), Gaps = 14/174 (8%)

Query: 19  AMQAGKVHLARFVLD--ALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAA 76
           A +AGK+H  RF+++  AL  +    RA  G TP   A      A     ++ LL QG  
Sbjct: 43  AARAGKLHCLRFLVEEAALPAA---ARARNGATPAHDASATGHLAC----LQWLLSQGGC 95

Query: 77  -VNLRDERGRTALSLACERGHLDAVQLLVQFSG-DPEAADSAGNSPVMWAAACGHGAVLE 134
            V  +D  G T L LA   GH + V  L+   G DP AA   G  P+ +AAA G    L 
Sbjct: 96  RVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLR 155

Query: 135 FLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARG 188
            LV  +   G+     N  G T L LA   GH    Q L    G    A A  G
Sbjct: 156 LLVEHYPE-GVNAQTKN--GATPLYLACQEGHLEVTQYLVQECGADPHARAHDG 206



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 40/131 (30%), Positives = 60/131 (45%), Gaps = 8/131 (6%)

Query: 43  RAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQL 102
           RA  G TPL  A  +    +    V L+     +++ +D+ G TA+  A  RGH   +  
Sbjct: 202 RAHDGMTPLHAAAQMGHSPV---IVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSW 258

Query: 103 LVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAA 162
           L+   G+  +AD  G +P+  AA  G     + LV +    G  LD  +R G TA  L+ 
Sbjct: 259 LLLHGGE-ISADLWGGTPLHDAAENGELECCQILVVN----GAELDVRDRDGYTAADLSD 313

Query: 163 ARGHGTCVQAL 173
             GH  C + L
Sbjct: 314 FNGHSHCTRYL 324



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 36/113 (31%), Positives = 52/113 (46%), Gaps = 4/113 (3%)

Query: 78  NLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSA-GNSPVMWAAACGHGAVLEFL 136
           +LRD      +  A   G L  ++ LV+ +  P AA +  G +P   A+A GH A L++L
Sbjct: 30  SLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWL 89

Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGS 189
           +      G R+   + +G T L LAA  GH   V  L    G    AA   G+
Sbjct: 90  LSQG---GCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGA 139



 Score = 29.6 bits (65), Expect = 4.7
 Identities = 49/184 (26%), Positives = 65/184 (35%), Gaps = 39/184 (21%)

Query: 183 AAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNSGR 242
           AA  + S    PP  P P   PE     P   P PL                SAG   G+
Sbjct: 586 AADPKASRELPPPPPPPPPPLPEAASSPPPAPPLPL---------------ESAGPGCGQ 630

Query: 243 HRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQS-------SGTGR--WR 293
            R+  S       +M    G    E  A ++AG   +L  +PQS       SG G+  ++
Sbjct: 631 RRSSSSTGSTKSFNMMSPTGD-NSELLAEIKAG--KSLKPTPQSKGLTTVFSGIGQPAFQ 687

Query: 294 SQEVLEGAPPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELE 353
               L    P L+      SP P   P +G   L   S  P  P+       P  G +L+
Sbjct: 688 PDSPLPSVSPALSPV---RSPTP---PAAGFQPLLNGSLVPVPPTT------PAPGVQLD 735

Query: 354 ANAL 357
             AL
Sbjct: 736 VEAL 739


>gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain
           containing 1 [Homo sapiens]
          Length = 475

 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 53/163 (32%), Positives = 80/163 (49%), Gaps = 16/163 (9%)

Query: 16  FLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGA 75
           F +AM  G V L + +LD+     +D   + G TPLM A  + +    A  VR+LL++GA
Sbjct: 50  FKKAMTIGDVSLVQELLDS--GISVDSNFQYGWTPLMYAASVAN----AELVRVLLDRGA 103

Query: 76  AVNLRDERGRTALSLAC-----ERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
             +   ++ ++ L  AC     E   L  V+LL+  + DP  A     +P+M+AA  GH 
Sbjct: 104 NASFEKDK-QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHT 162

Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
            V+  LV      G  ++  +  G TAL  AA +GH   V  L
Sbjct: 163 QVVALLVAH----GAEVNTQDENGYTALTWAARQGHKNIVLKL 201



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 23/70 (32%), Positives = 32/70 (45%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
           V LL+  GA VN +DE G TAL+ A  +GH + V  L++   +       G  P   A  
Sbjct: 165 VALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKR 224

Query: 127 CGHGAVLEFL 136
             H  +   L
Sbjct: 225 NKHHEIFNLL 234


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 41/112 (36%), Positives = 61/112 (54%), Gaps = 6/112 (5%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF--SGDPEAADSAGNSPVMWA 124
           +  LL+  A  ++RD+ G  ++  A   GH   ++LL++   SG  E+   A  SP+  A
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLA 549

Query: 125 AACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGP 176
           A  GH   LE L++S   L +R ++    G TAL LAA +GH  CV+AL  P
Sbjct: 550 AYNGHHQALEVLLQSLVDLDIRDEK----GRTALDLAAFKGHTECVEALINP 597



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 51/173 (29%), Positives = 72/173 (41%), Gaps = 22/173 (12%)

Query: 33  DALDRSIIDCRAE------QGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRT 86
           DA+   +ID  A        G TPL  A      AL    + LL+  GA VN++ + G++
Sbjct: 227 DAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL---CLELLVNNGADVNIQSKDGKS 283

Query: 87  ALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLR 146
            L +    G     Q L+Q  G+ +  D  GN+P+  AA  GH    E L+ + R  G  
Sbjct: 284 PLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH----ELLINTLRTSGAD 339

Query: 147 LDRTNRAGLTALQLAAARGHGTCVQALTG---------PWGRAAAAAAARGSN 190
             +     +  L LAA   H  C + L            +GR    AAA G N
Sbjct: 340 TAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGN 392



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 40/103 (38%), Positives = 54/103 (52%), Gaps = 5/103 (4%)

Query: 28  ARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTA 87
           A  +L A+D SI+ CR ++GRTPL  A      A     ++LLL   A VN  D  G+TA
Sbjct: 795 ASLLLGAIDSSIVSCRDDKGRTPLRAAAF----ADHVECLQLLLRHSAPVNAVDNSGKTA 850

Query: 88  LSLACERGHLDAVQLLVQFS-GDPEAADSAGNSPVMWAAACGH 129
           L +A E G   AV +LV  +  D    D   N+P+  A + GH
Sbjct: 851 LMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 39/107 (36%), Positives = 54/107 (50%), Gaps = 4/107 (3%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
           V LLL +GA +N  D++ R AL  A   GHLD V LL+    +    D  G +P+  AA+
Sbjct: 131 VNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAAS 190

Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
            G   V++ L+     LG+ +D  N  G TAL +A   G    V  L
Sbjct: 191 NGQINVVKHLL----NLGVEIDEINVYGNTALHIACYNGQDAVVNEL 233



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 47/146 (32%), Positives = 70/146 (47%), Gaps = 6/146 (4%)

Query: 29  RFVLDALDR-SIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTA 87
           R +L+  D    +D +  +G+TPLM+AV           V LLLE+ A V+  D  G TA
Sbjct: 626 RLLLEIADNPEAVDVKDAKGQTPLMLAVAYG----HIDAVSLLLEKEANVDTVDILGCTA 681

Query: 88  LSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRL 147
           L      GH + VQ+L++        DS G +P+ +AAA GH   L  L++         
Sbjct: 682 LHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCC 741

Query: 148 DRTNRAGLTALQLAAARGHGTCVQAL 173
            + N+ G T L  A   G+  C++ L
Sbjct: 742 FKDNQ-GYTPLHWACYNGNENCIEVL 766



 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 43/126 (34%), Positives = 58/126 (46%), Gaps = 8/126 (6%)

Query: 48  RTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFS 107
           RTPL VA  L D    A  + LL+  GA VN +D    T L  A      +AVQ+L++ S
Sbjct: 17  RTPLHVAAFLGD----AEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72

Query: 108 GDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHG 167
            D  A D    +P+  AAA       E ++     + +    ++R G TAL  AA  GH 
Sbjct: 73  ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV----SDRGGRTALHHAALNGHV 128

Query: 168 TCVQAL 173
             V  L
Sbjct: 129 EMVNLL 134



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 31/93 (33%), Positives = 50/93 (53%), Gaps = 3/93 (3%)

Query: 77  VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
           V+ RD++GRT L  A    H++ +QLL++ S    A D++G + +M AA  G    ++ L
Sbjct: 807 VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL 866

Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAARGHGTC 169
           V S +     L   ++   T L LA ++GH  C
Sbjct: 867 VNSAQ---ADLTVKDKDLNTPLHLACSKGHEKC 896



 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 40/144 (27%), Positives = 61/144 (42%), Gaps = 41/144 (28%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQ------------------------- 101
           + +LL+    +++RDE+GRTAL LA  +GH + V+                         
Sbjct: 558 LEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASV 617

Query: 102 ---------LLVQFSGDPEAA---DSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDR 149
                    LL++ + +PEA    D+ G +P+M A A GH   +  L+         +D 
Sbjct: 618 INGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEK----EANVDT 673

Query: 150 TNRAGLTALQLAAARGHGTCVQAL 173
            +  G TAL      GH  CVQ L
Sbjct: 674 VDILGCTALHRGIMTGHEECVQML 697



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 40/134 (29%), Positives = 60/134 (44%), Gaps = 8/134 (5%)

Query: 40  IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
           ++ R +  +TPL VA            + LL    ++VN+ D  GRTAL  A   GH++ 
Sbjct: 75  VNARDKNWQTPLHVAAANKAVKCAEVIIPLL----SSVNVSDRGGRTALHHAALNGHVEM 130

Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQ 159
           V LL+    +  A D      + WAA  GH  V+  L+      G  +   ++ G T L 
Sbjct: 131 VNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH----GAEVTCKDKKGYTPLH 186

Query: 160 LAAARGHGTCVQAL 173
            AA+ G    V+ L
Sbjct: 187 AAASNGQINVVKHL 200



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 39/135 (28%), Positives = 65/135 (48%), Gaps = 9/135 (6%)

Query: 40  IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
           + C+ ++G TPL  A        +   V+ LL  G  ++  +  G TAL +AC  G    
Sbjct: 174 VTCKDKKGYTPLHAAASNG----QINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAV 229

Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAV-LEFLVRSFRRLGLRLDRTNRAGLTAL 158
           V  L+ +  +    ++ G +P+ +AAA  HGA+ LE LV +    G  ++  ++ G + L
Sbjct: 230 VNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNN----GADVNIQSKDGKSPL 285

Query: 159 QLAAARGHGTCVQAL 173
            + A  G  T  Q L
Sbjct: 286 HMTAVHGRFTRSQTL 300



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 44/156 (28%), Positives = 60/156 (38%), Gaps = 17/156 (10%)

Query: 40  IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
           IDC  + G TPL VA       L    +  L   GA            L LA    H D 
Sbjct: 307 IDCVDKDGNTPLHVAARYGHELL----INTLRTSGADTAKCGIHSMFPLHLAALNAHSDC 362

Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQ 159
            + L+    + +  D  G + +  AAA G+   ++ L  S    G    + ++ G T L 
Sbjct: 363 CRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSS----GADFHKKDKCGRTPLH 418

Query: 160 LAAARGHGTCVQAL---------TGPWGRAAAAAAA 186
            AAA  H  C++ L         T  WGR A   AA
Sbjct: 419 YAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 31/109 (28%), Positives = 51/109 (46%), Gaps = 5/109 (4%)

Query: 67  VRLLLEQGAAVNLRDERGRTA--LSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWA 124
           + LLLE+  +     + G T   L LA   GH  A+++L+Q   D +  D  G + +  A
Sbjct: 523 LELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLA 582

Query: 125 AACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
           A  GH   +E L+     + ++ + T R   T L  +   GH  C++ L
Sbjct: 583 AFKGHTECVEALINPGASIFVKDNVTKR---TPLHASVINGHTLCLRLL 628


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 51/144 (35%), Positives = 70/144 (48%), Gaps = 6/144 (4%)

Query: 31  VLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSL 90
           +L AL   I++ R  +GRTPL  A      A     +R+LL+  A VN  D  GRTAL  
Sbjct: 842 LLGALGAKIVNSRDAKGRTPLHAAAF----ADNVSGLRMLLQHQAEVNATDHTGRTALMT 897

Query: 91  ACERGHLDAVQ-LLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDR 149
           A E G   AV+ LL +   D    D   N+ +  A + GH      ++   + LGL ++ 
Sbjct: 898 AAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGL-INA 956

Query: 150 TNRAGLTALQLAAARGHGTCVQAL 173
           TN A    L +AA  G  + VQAL
Sbjct: 957 TNSALQMPLHIAARNGLASVVQAL 980



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 48/158 (30%), Positives = 75/158 (47%), Gaps = 9/158 (5%)

Query: 19  AMQAGKVHLARFVLDALDRS-IIDCRAEQGRTPLMVAV--GLPDPALRARFVRLLLEQGA 75
           A  +G       ++D+ +R+ I D     G+TPLM+A+  G  D       V LLLE+G+
Sbjct: 659 AAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVD------CVHLLLEKGS 712

Query: 76  AVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEF 135
             +  D RGRTAL      G  D +  L+         D  G +P+  A+ACGH AVL  
Sbjct: 713 TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772

Query: 136 LVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
           L+++           + +G + +  A+  GH  C++ L
Sbjct: 773 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810



 Score = 55.5 bits (132), Expect = 8e-08
 Identities = 36/99 (36%), Positives = 53/99 (53%), Gaps = 4/99 (4%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
           V LLL +GA++N+ D++ R  L  A   GHL+ ++LLV    D    D  G   +  AAA
Sbjct: 156 VNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAA 215

Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARG 165
            G   V+++L+    R+G  +D  N  G TAL +A   G
Sbjct: 216 SGQIEVVKYLL----RMGAEIDEPNAFGNTALHIACYLG 250



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 43/134 (32%), Positives = 59/134 (44%), Gaps = 8/134 (5%)

Query: 40  IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
           ++ R +  +TPL VA              LL    +++N+ D  GR+AL  A   GHL+ 
Sbjct: 100 VNARDKLWQTPLHVAAANRATKCAEALAPLL----SSLNVADRSGRSALHHAVHSGHLET 155

Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQ 159
           V LL+         D     P+ WAA  GH  VL+ LV     LG +    +R G   L 
Sbjct: 156 VNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCK----DRKGYGLLH 211

Query: 160 LAAARGHGTCVQAL 173
            AAA G    V+ L
Sbjct: 212 TAAASGQIEVVKYL 225



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 40/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)

Query: 45  EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLV 104
           ++G TPL VA    + AL    + LL+  GA VN + + G++ L +A   G     Q+L+
Sbjct: 270 DKGFTPLHVAAVSTNGAL---CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326

Query: 105 QFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAAR 164
           Q   + + AD  GN+P+  AA  GH    E L+ +    G    R     +  L LA   
Sbjct: 327 QNGSEIDCADKFGNTPLHVAARYGH----ELLISTLMTNGADTARRGIHDMFPLHLAVLF 382

Query: 165 GHGTCVQAL 173
           G   C + L
Sbjct: 383 GFSDCCRKL 391



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 43/123 (34%), Positives = 58/123 (47%), Gaps = 3/123 (2%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGN-SPVMWAA 125
           ++ L E    +++RD +GRTAL LA ERG  + V++L          +     +P+  AA
Sbjct: 601 LKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAA 660

Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAA 185
           A GH   L  L+ S  R  +  D  +  G T L LA   GH  CV  L    G  A AA 
Sbjct: 661 ASGHTDSLHLLIDSGERADI-TDVMDAYGQTPLMLAIMNGHVDCVHLLLEK-GSTADAAD 718

Query: 186 ARG 188
            RG
Sbjct: 719 LRG 721



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 44/138 (31%), Positives = 61/138 (44%), Gaps = 14/138 (10%)

Query: 6   DLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLM--VAVGLPDPALR 63
           D+    G    + A+  G V     +L+    S  D    +GRT L      G  D    
Sbjct: 682 DVMDAYGQTPLMLAIMNGHVDCVHLLLEK--GSTADAADLRGRTALHRGAVTGCED---- 735

Query: 64  ARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQ--FSGDPEAA--DSAGNS 119
              +  LL+  A V  RD +GRT + LA   GH   ++ L+Q   S DP  A  D +G S
Sbjct: 736 --CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYS 793

Query: 120 PVMWAAACGHGAVLEFLV 137
           P+ WA+  GH   LE L+
Sbjct: 794 PMHWASYTGHEDCLELLL 811



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 33/107 (30%), Positives = 50/107 (46%), Gaps = 4/107 (3%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
           VR LL Q   +N+ D+  RT L  A   G +  +QLL+    +  A D+   +P+  AAA
Sbjct: 24  VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAA 83

Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
             +  VL  L+     +  R    ++   T L +AAA     C +AL
Sbjct: 84  SRNEKVLGLLLAHSADVNAR----DKLWQTPLHVAAANRATKCAEAL 126



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 36/109 (33%), Positives = 55/109 (50%), Gaps = 7/109 (6%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQL-LVQFSGDPEAADSAGNSPVMWAA 125
           V+ LL  GA ++  +  G TAL +AC  G  DAV + LV    +    +  G +P+  AA
Sbjct: 222 VKYLLRMGAEIDEPNAFGNTALHIACYLGQ-DAVAIELVNAGANVNQPNDKGFTPLHVAA 280

Query: 126 ACGHGAV-LEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
              +GA+ LE LV +    G  ++  ++ G + L +AA  G  T  Q L
Sbjct: 281 VSTNGALCLELLVNN----GADVNYQSKEGKSPLHMAAIHGRFTRSQIL 325



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 23/60 (38%), Positives = 28/60 (46%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
           + LLL  GA +  RD+ GRT L  A   G       LV        AD  G SP+ +AAA
Sbjct: 439 LNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAA 498



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 52/192 (27%), Positives = 69/192 (35%), Gaps = 32/192 (16%)

Query: 38  SIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLA------ 91
           S IDC  + G TPL VA       L    +  L+  GA    R       L LA      
Sbjct: 330 SEIDCADKFGNTPLHVAARYGHELL----ISTLMTNGADTARRGIHDMFPLHLAVLFGFS 385

Query: 92  -CERGHLDAVQL-----------LVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRS 139
            C R  L + QL           ++    D    D+ G + +  AA+ G+   L  L+ S
Sbjct: 386 DCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS 445

Query: 140 FRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSDSPPGRPA 199
               G  L R ++ G T L  AAA G   C   L        A A    ++         
Sbjct: 446 ----GADLRRRDKFGRTPLHYAAANGSYQCAVTL------VTAGAGVNEADCKGCSPLHY 495

Query: 200 PAASPEHRRPSP 211
            AAS  +RR  P
Sbjct: 496 AAASDTYRRAEP 507



 Score = 30.8 bits (68), Expect = 2.1
 Identities = 30/106 (28%), Positives = 40/106 (37%), Gaps = 31/106 (29%)

Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVR-SFRRLG-------------- 144
           ++ L+    DP   D  G + V +AAA G+   LE L+  SF  L               
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592

Query: 145 ----------------LRLDRTNRAGLTALQLAAARGHGTCVQALT 174
                           + LD  +  G TAL LA  RG   CV+ LT
Sbjct: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLT 638


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 36/107 (33%), Positives = 57/107 (53%), Gaps = 4/107 (3%)

Query: 67  VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
           V  LL+ G  +  RD  G TAL  AC +G  D V+LL+    +P         P++WAA 
Sbjct: 87  VEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAG 146

Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
            GH  ++  L+++    G +++ +++ G T L  AA +GH  CV+ L
Sbjct: 147 RGHADIVHLLLQN----GAKVNCSDKYGTTPLVWAARKGHLECVKHL 189



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 43/134 (32%), Positives = 62/134 (46%), Gaps = 8/134 (5%)

Query: 40  IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
           +D R E G+TPLM+A    +       V+ L++ GA  NL D    TAL  A + GH+  
Sbjct: 31  VDERNECGQTPLMIAAEQGN----LEIVKELIKNGANCNLEDLDNWTALISASKEGHVHI 86

Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQ 159
           V+ L++   + E  D  G + +MWA   G   V+E L+      G     T    +  + 
Sbjct: 87  VEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSH----GANPSVTGLYSVYPII 142

Query: 160 LAAARGHGTCVQAL 173
            AA RGH   V  L
Sbjct: 143 WAAGRGHADIVHLL 156



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 37/111 (33%), Positives = 57/111 (51%), Gaps = 6/111 (5%)

Query: 64  ARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMW 123
           A  V LLL+ GA VN  D+ G T L  A  +GHL+ V+ L+    D +   +   + ++ 
Sbjct: 150 ADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIV 209

Query: 124 AAACGH-GAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
           A   G+  +V E L R+       ++ T++ G TAL +A+  GH   VQ L
Sbjct: 210 AVKGGYTQSVKEILKRN-----PNVNLTDKDGNTALMIASKEGHTEIVQDL 255



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 41/160 (25%), Positives = 75/160 (46%), Gaps = 10/160 (6%)

Query: 12  GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
           GT   + A + G +   + +L     + +D       T L+VAV         + V+ +L
Sbjct: 170 GTTPLVWAARKGHLECVKHLLAM--GADVDQEGANSMTALIVAV----KGGYTQSVKEIL 223

Query: 72  EQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGA 131
           ++   VNL D+ G TAL +A + GH + VQ L+         D +G++ ++ A   GH  
Sbjct: 224 KRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVE 283

Query: 132 VLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQ 171
           ++  L++ +  + +R     +   TAL  A  +G+ T V+
Sbjct: 284 IVRALLQKYADIDIR----GQDNKTALYWAVEKGNATMVR 319



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 35/114 (30%), Positives = 61/114 (53%), Gaps = 9/114 (7%)

Query: 60  PALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNS 119
           PAL+A     LLE+   V+ R+E G+T L +A E+G+L+ V+ L++   +    D    +
Sbjct: 19  PALKA-----LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 120 PVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
            ++ A+  GH  ++E L+    + G+ L+  +  G TAL  A  +G    V+ L
Sbjct: 74  ALISASKEGHVHIVEELL----KCGVNLEHRDMGGWTALMWACYKGRTDVVELL 123



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 39/156 (25%), Positives = 74/156 (47%), Gaps = 10/156 (6%)

Query: 6   DLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRAR 65
           +L  + G    + A + G   + + +LDA   + ++     G T L+ AV          
Sbjct: 230 NLTDKDGNTALMIASKEGHTEIVQDLLDA--GTYVNIPDRSGDTVLIGAVR----GGHVE 283

Query: 66  FVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
            VR LL++ A +++R +  +TAL  A E+G+   V+ ++Q + D E     G +P++ A 
Sbjct: 284 IVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKAT 343

Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLA 161
              +  V+E L+      G ++   ++ G T L +A
Sbjct: 344 KMRNIEVVELLLDK----GAKVSAVDKKGDTPLHIA 375



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 28/102 (27%), Positives = 45/102 (44%), Gaps = 15/102 (14%)

Query: 37  RSIIDCRAE------QGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSL 90
           R I+ C  +       G TPL+ A  + +       V LLL++GA V+  D++G T L +
Sbjct: 319 RDILQCNPDTEICTKDGETPLIKATKMRN----IEVVELLLDKGAKVSAVDKKGDTPLHI 374

Query: 91  ACERGHLDAVQLLVQFSGDPE---AADSAGNSPVMWAAACGH 129
           A         +LL++   D       + AG +P  +   C H
Sbjct: 375 AIRGRSRKLAELLLRNPKDGRLLYRPNKAGETP--YNIDCSH 414


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,533,470
Number of Sequences: 37866
Number of extensions: 1055468
Number of successful extensions: 11403
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 381
Number of HSP's successfully gapped in prelim test: 733
Number of HSP's that attempted gapping in prelim test: 8030
Number of HSP's gapped (non-prelim): 3332
length of query: 380
length of database: 18,247,518
effective HSP length: 104
effective length of query: 276
effective length of database: 14,309,454
effective search space: 3949409304
effective search space used: 3949409304
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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