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Search of human proteins with 169208593
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169208593 PREDICTED: similar to kinase D-interacting
substrate 220 [Homo sapiens]
(380 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169208819 PREDICTED: similar to kinase D-interacting substrat... 757 0.0
gi|169208593 PREDICTED: similar to kinase D-interacting substrat... 757 0.0
gi|169208169 PREDICTED: similar to kinase D-interacting substrat... 754 0.0
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 78 1e-14
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 77 2e-14
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 75 7e-14
gi|89941470 ankyrin repeat domain 34 [Homo sapiens] 74 2e-13
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 74 2e-13
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 74 2e-13
gi|38257146 ankyrin repeat domain 46 [Homo sapiens] 70 2e-12
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 70 3e-12
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 70 3e-12
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 70 4e-12
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 68 1e-11
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 67 3e-11
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 67 3e-11
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 67 3e-11
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 67 3e-11
gi|169167742 PREDICTED: ankyrin repeat domain 33B [Homo sapiens] 66 5e-11
gi|113416996 PREDICTED: ankyrin repeat domain 33B [Homo sapiens] 66 5e-11
gi|239742483 PREDICTED: ankyrin repeat domain 33B [Homo sapiens] 66 5e-11
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 66 5e-11
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 66 5e-11
gi|55770876 notch4 preproprotein [Homo sapiens] 64 2e-10
gi|18079216 CASK interacting protein 1 [Homo sapiens] 64 2e-10
gi|110431370 espin [Homo sapiens] 64 2e-10
gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain ... 63 4e-10
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 63 4e-10
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 63 4e-10
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 63 5e-10
>gi|169208819 PREDICTED: similar to kinase D-interacting substrate
220 [Homo sapiens]
Length = 380
Score = 757 bits (1954), Expect = 0.0
Identities = 380/380 (100%), Positives = 380/380 (100%)
Query: 1 MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP 60
MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP
Sbjct: 1 MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP 60
Query: 61 ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP 120
ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP
Sbjct: 61 ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP 120
Query: 121 VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA 180
VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA
Sbjct: 121 VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA 180
Query: 181 AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS 240
AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS
Sbjct: 181 AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS 240
Query: 241 GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG 300
GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG
Sbjct: 241 GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG 300
Query: 301 APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS 360
APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS
Sbjct: 301 APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS 360
Query: 361 VPGPNPWQAGTEAVVLRAQR 380
VPGPNPWQAGTEAVVLRAQR
Sbjct: 361 VPGPNPWQAGTEAVVLRAQR 380
>gi|169208593 PREDICTED: similar to kinase D-interacting substrate
220 [Homo sapiens]
Length = 380
Score = 757 bits (1954), Expect = 0.0
Identities = 380/380 (100%), Positives = 380/380 (100%)
Query: 1 MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP 60
MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP
Sbjct: 1 MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP 60
Query: 61 ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP 120
ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP
Sbjct: 61 ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP 120
Query: 121 VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA 180
VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA
Sbjct: 121 VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA 180
Query: 181 AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS 240
AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS
Sbjct: 181 AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS 240
Query: 241 GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG 300
GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG
Sbjct: 241 GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG 300
Query: 301 APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS 360
APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS
Sbjct: 301 APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS 360
Query: 361 VPGPNPWQAGTEAVVLRAQR 380
VPGPNPWQAGTEAVVLRAQR
Sbjct: 361 VPGPNPWQAGTEAVVLRAQR 380
>gi|169208169 PREDICTED: similar to kinase D-interacting substrate
220 [Homo sapiens]
Length = 380
Score = 754 bits (1946), Expect = 0.0
Identities = 379/380 (99%), Positives = 379/380 (99%)
Query: 1 MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP 60
MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP
Sbjct: 1 MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDP 60
Query: 61 ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP 120
ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP
Sbjct: 61 ALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSP 120
Query: 121 VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA 180
VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA
Sbjct: 121 VMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRA 180
Query: 181 AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS 240
AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS
Sbjct: 181 AAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNS 240
Query: 241 GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG 300
GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG
Sbjct: 241 GRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEG 300
Query: 301 APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALPVS 360
APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANAL VS
Sbjct: 301 APPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALSVS 360
Query: 361 VPGPNPWQAGTEAVVLRAQR 380
VPGPNPWQAGTEAVVLRAQR
Sbjct: 361 VPGPNPWQAGTEAVVLRAQR 380
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 78.2 bits (191), Expect = 1e-14
Identities = 54/161 (33%), Positives = 79/161 (49%), Gaps = 17/161 (10%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
++C+ GR P + + L + A + LE GA V D GRTAL ++C +GH++
Sbjct: 939 VNCKDADGR-PTLYILALENQLTMAEY---FLENGANVEASDAEGRTALHVSCWQGHMEM 994
Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQ 159
VQ+L+ + D AAD+ S + AA GH V++ L+ G +D T G TAL
Sbjct: 995 VQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEH----GAVVDHTCNQGATALC 1050
Query: 160 LAAARGHGTCVQAL---------TGPWGRAAAAAAARGSNS 191
+AA GH VQ L +GR A AA+ +S
Sbjct: 1051 IAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHS 1091
Score = 73.9 bits (180), Expect = 2e-13
Identities = 60/171 (35%), Positives = 80/171 (46%), Gaps = 17/171 (9%)
Query: 31 VLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSL 90
VL L ++ +E RT +V L R +R LL+ GA+VN D GRT L+
Sbjct: 496 VLQLLVKAGAHVNSEDDRTSCIVRQALE----REDSIRTLLDNGASVNQCDSNGRTLLAN 551
Query: 91 ACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRT 150
A G LD V LLV D E D+ G++P+ AA GH V+ L+ G ++ T
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLI----GCGANINHT 607
Query: 151 NRAGLTALQLAAARGHGTCVQAL---------TGPWGRAAAAAAARGSNSD 192
++ G TAL+ AA GH V AL R A AAA G + D
Sbjct: 608 DQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHED 658
Score = 73.9 bits (180), Expect = 2e-13
Identities = 55/168 (32%), Positives = 78/168 (46%), Gaps = 10/168 (5%)
Query: 6 DLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRAR 65
D C + G L A G V + +L+ + +D GRTPL+ A + A
Sbjct: 742 DHCDKDGMTPLLVAAYEGHVDVVDLLLEG--GADVDHTDNNGRTPLLAAASMG----HAS 795
Query: 66 FVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
V LL GAAV+ D GRT LS+A +G+++ V+ L+ D D AG +P+ AA
Sbjct: 796 VVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAA 855
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
GH + E L+ G R + + G LA+ GH CVQ L
Sbjct: 856 FEGHRLICEALIEQ----GARTNEIDNDGRIPFILASQEGHYDCVQIL 899
Score = 69.3 bits (168), Expect = 5e-12
Identities = 45/128 (35%), Positives = 72/128 (56%), Gaps = 5/128 (3%)
Query: 47 GRTPLMVA-VGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQ 105
GRT L VA + +P A V LL+++GA V+ D+ G T L +A GH+D V LL++
Sbjct: 710 GRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769
Query: 106 FSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARG 165
D + D+ G +P++ AA+ GH +V+ L+ G +D + G T L +A+A+G
Sbjct: 770 GGADVDHTDNNGRTPLLAAASMGHASVVNTLL----FWGAAVDSIDSEGRTVLSIASAQG 825
Query: 166 HGTCVQAL 173
+ V+ L
Sbjct: 826 NVEVVRTL 833
Score = 59.3 bits (142), Expect = 6e-09
Identities = 28/72 (38%), Positives = 44/72 (61%)
Query: 65 RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWA 124
+ V+LL+E GA V+ +G TAL +A + GH+D VQ+L++ DP AD G + + A
Sbjct: 1026 KVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVA 1085
Query: 125 AACGHGAVLEFL 136
A GH +++ L
Sbjct: 1086 AKNGHSQIIKLL 1097
Score = 50.1 bits (118), Expect = 3e-06
Identities = 37/112 (33%), Positives = 54/112 (48%), Gaps = 9/112 (8%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
V LL G V+ D RTAL A GH D V L+Q + AD+ G + ++ AA
Sbjct: 627 VSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAY 686
Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLA-----AARGHGTCVQAL 173
GH ++E L+ G ++ + G TAL +A A++GH + V L
Sbjct: 687 MGHREIVEHLLDH----GAEVNHEDVDGRTALSVAALCVPASKGHASVVSLL 734
Score = 48.9 bits (115), Expect = 7e-06
Identities = 52/191 (27%), Positives = 76/191 (39%), Gaps = 38/191 (19%)
Query: 14 RTFLEAMQA-GKVHLARFVLD-ALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
RT L A G V + R +LD LD + D + G TPL +A + L+
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRD---DAGWTPLHMAAFEGHRLI----CEALI 867
Query: 72 EQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGA 131
EQGA N D GR LA + GH D VQ+L++ + + G + + AA GH
Sbjct: 868 EQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRD 927
Query: 132 VLEFL-----------------------------VRSFRRLGLRLDRTNRAGLTALQLAA 162
++E L F G ++ ++ G TAL ++
Sbjct: 928 IVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSC 987
Query: 163 ARGHGTCVQAL 173
+GH VQ L
Sbjct: 988 WQGHMEMVQVL 998
Score = 40.4 bits (93), Expect = 0.003
Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 6/84 (7%)
Query: 38 SIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHL 97
+++D QG T L +A V++LLE GA N D+ GRTA+ +A + GH
Sbjct: 1036 AVVDHTCNQGATALCIAA----QEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHS 1091
Query: 98 DAVQLLVQFSGDPEAADSAGNSPV 121
++LL ++ + + SPV
Sbjct: 1092 QIIKLLEKYGA--SSLNGCSPSPV 1113
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 77.4 bits (189), Expect = 2e-14
Identities = 67/186 (36%), Positives = 87/186 (46%), Gaps = 14/186 (7%)
Query: 17 LEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAA 76
L A AG+ RF+L R +D R G T L +A L R++ + +LL GA
Sbjct: 208 LVAAAAGRGAALRFLLARGAR--VDARDGAGATALGLAAALG----RSQDIEVLLGHGAD 261
Query: 77 VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
+RD GR+AL A RGHL AVQLLV + +A D+ G +P+ A+ GH V L
Sbjct: 262 PGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCL 321
Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL----TGPWGRAAAAAAARGSNSD 192
+ G ++D T T L LAA RGHG V L P R A A+ D
Sbjct: 322 LDR----GAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGD 377
Query: 193 SPPGRP 198
P P
Sbjct: 378 LPQALP 383
Score = 68.9 bits (167), Expect = 7e-12
Identities = 53/128 (41%), Positives = 61/128 (47%), Gaps = 7/128 (5%)
Query: 64 ARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMW 123
A V LL QGA+V RD GRT L LA RGH V+LL+Q A D AG + +
Sbjct: 54 AGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHE 113
Query: 124 AAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL---TGPWGRA 180
AA GH V E L++ G + GLT L AAA GH L GP A
Sbjct: 114 AAWHGHSRVAELLLQR----GASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAA 169
Query: 181 AAAAAARG 188
A A ARG
Sbjct: 170 AEAEDARG 177
Score = 58.2 bits (139), Expect = 1e-08
Identities = 68/220 (30%), Positives = 83/220 (37%), Gaps = 77/220 (35%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALR--ARFVRLLLEQGAAVNLRDERGRTALSLACERGHL 97
++ R GRTPL +AV LR A VRLLL++GA V D GRTAL A GH
Sbjct: 67 VEERDHAGRTPLHLAV------LRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHS 120
Query: 98 DAVQLLVQFSGDPEAADSAGNSPVMWAAACG----------------------------- 128
+LL+Q A G +P+ WAAA G
Sbjct: 121 RVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTA 180
Query: 129 --------HGAVLEFL----------------------VRSFRRLGLRLDRTNRAGLTAL 158
AVLE L +R G R+D + AG TAL
Sbjct: 181 AHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATAL 240
Query: 159 QLAAARGHGTCVQALTG---------PWGRAAA-AAAARG 188
LAAA G ++ L G GR+A AAARG
Sbjct: 241 GLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 75.5 bits (184), Expect = 7e-14
Identities = 51/143 (35%), Positives = 73/143 (51%), Gaps = 8/143 (5%)
Query: 33 DALDRSIIDCRAEQGRTPLMVAV--GLPDPALRARFVRLLLEQGAAVNLRDERGRTALSL 90
+A ++ +D + G+TPLM++V G D V LL +GA V+ +D+ GRTAL
Sbjct: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTD------CVYSLLNKGANVDAKDKWGRTALHR 692
Query: 91 ACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRT 150
GH + V L+Q DS G +P+ +AACGH VL L++S +
Sbjct: 693 GAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATA 752
Query: 151 NRAGLTALQLAAARGHGTCVQAL 173
+ G TAL A GH TCV+ L
Sbjct: 753 DNHGYTALHWACYNGHETCVELL 775
Score = 61.6 bits (148), Expect = 1e-09
Identities = 51/173 (29%), Positives = 73/173 (42%), Gaps = 22/173 (12%)
Query: 33 DALDRSIIDCRA------EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRT 86
D + +IDC A E+G TPL A AL + LL+ GA VN++ + G+T
Sbjct: 252 DVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL---CLELLVGNGADVNMKSKDGKT 308
Query: 87 ALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLR 146
L + G Q ++Q + D GN+P+ AA GH ++ L+ S G
Sbjct: 309 PLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS----GAD 364
Query: 147 LDRTNRAGLTALQLAAARGHGTCVQALTG---------PWGRAAAAAAARGSN 190
+ G+ L LAA G C + L +GR AAA G N
Sbjct: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGN 417
Score = 59.7 bits (143), Expect = 4e-09
Identities = 52/174 (29%), Positives = 77/174 (44%), Gaps = 10/174 (5%)
Query: 28 ARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTA 87
A ++D L SI++ +GRTPL A ++LLL A VN D G+T
Sbjct: 804 AEMLIDTLGASIVNATDSKGRTPLHAAAFTD----HVECLQLLLSHNAQVNSVDSTGKTP 859
Query: 88 LSLACERGHLDAVQLLV-QFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLR 146
L +A E G + V++LV S + D++ N+ + A + GH ++ L
Sbjct: 860 LMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL- 918
Query: 147 LDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSDSPPGRPAP 200
++ TN A T L +AA G VQ L G A+ A N +P AP
Sbjct: 919 INATNAALQTPLHVAARNGLTMVVQELLG----KGASVLAVDENGYTPALACAP 968
Score = 57.4 bits (137), Expect = 2e-08
Identities = 46/134 (34%), Positives = 65/134 (48%), Gaps = 8/134 (5%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
++ + + RTPL A L D A + LL+ GA VN +D + T L A +A
Sbjct: 34 VNFQDNEKRTPLHAAAYLGD----AEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEA 89
Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQ 159
VQ+L++ S D A D +P+ AAA E LV + + ++RAG TAL
Sbjct: 90 VQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV----SDRAGRTALH 145
Query: 160 LAAARGHGTCVQAL 173
AA GHG V+ L
Sbjct: 146 HAAFSGHGEMVKLL 159
Score = 55.8 bits (133), Expect = 6e-08
Identities = 40/142 (28%), Positives = 66/142 (46%), Gaps = 15/142 (10%)
Query: 43 RAEQGRTPLMVAVGLPDPALRA-----------RFVRLLLEQGAAVNLRDERGRTALSLA 91
+ + PL+ V + D A R V+LLL +GA +N D++ R A+ A
Sbjct: 121 KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA 180
Query: 92 CERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTN 151
GH++ V+LLV + D +P+ AA+ G +V+++L+ LG+ ++ N
Sbjct: 181 AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL----DLGVDMNEPN 236
Query: 152 RAGLTALQLAAARGHGTCVQAL 173
G T L +A G V L
Sbjct: 237 AYGNTPLHVACYNGQDVVVNEL 258
Score = 48.1 bits (113), Expect = 1e-05
Identities = 47/199 (23%), Positives = 72/199 (36%), Gaps = 67/199 (33%)
Query: 38 SIIDCRAEQGRTPLMVAVGLPDPALRARFV-----------------------------R 68
++IDC + G TPL +A L + R
Sbjct: 330 AVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCR 389
Query: 69 LLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA-C 127
LL G ++ D+ GRT L A G+L+ + LL+ D D G SP+ +AAA C
Sbjct: 390 KLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANC 449
Query: 128 GH---------------------------------GAVLEFLVRSFRRLGLRLDRTNRAG 154
+ G LE+L+R+ G+R ++ G
Sbjct: 450 NYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIR----DKQG 505
Query: 155 LTALQLAAARGHGTCVQAL 173
A+ +AA GH C+Q +
Sbjct: 506 YNAVHYSAAYGHRLCLQLI 524
Score = 45.4 bits (106), Expect = 8e-05
Identities = 34/125 (27%), Positives = 55/125 (44%), Gaps = 11/125 (8%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAAD-SAGNSPVMWAA 125
+ +L++ +++R+ GRT L LA +GH++ V +L+ D +P+ AA
Sbjct: 566 LEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAA 625
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTG---------P 176
GH L L+ + +D + G T L L+ GH CV +L
Sbjct: 626 TNGHSECLRLLIGNAEPQN-AVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDK 684
Query: 177 WGRAA 181
WGR A
Sbjct: 685 WGRTA 689
Score = 44.3 bits (103), Expect = 2e-04
Identities = 40/156 (25%), Positives = 68/156 (43%), Gaps = 13/156 (8%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
+ C+ ++ TPL A + V+ LL+ G +N + G T L +AC G
Sbjct: 199 VTCKDKKSYTPLHAAAS----SGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVV 254
Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAV-LEFLVRSFRRLGLRLDRTNRAGLTAL 158
V L+ + G +P+ +AAA HGA+ LE LV + G ++ ++ G T L
Sbjct: 255 VNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGN----GADVNMKSKDGKTPL 310
Query: 159 QLAAARGHGTCVQALTGPWGRAAAAAAARGSNSDSP 194
+ A G + Q + ++ A N ++P
Sbjct: 311 HMTALHGRFSRSQTII----QSGAVIDCEDKNGNTP 342
Score = 43.9 bits (102), Expect = 2e-04
Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 6/110 (5%)
Query: 69 LLLEQGAAVNLRDERGRTALS---LACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
+L+E L D R +S LA GH A+++LVQ D + +S+G +P+ AA
Sbjct: 532 VLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAA 591
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTG 175
GH ++ L+ + ++ R T + AA GH C++ L G
Sbjct: 592 FKGHVECVDVLINQGASILVKDYILKR---TPIHAAATNGHSECLRLLIG 638
Score = 40.8 bits (94), Expect = 0.002
Identities = 43/158 (27%), Positives = 66/158 (41%), Gaps = 7/158 (4%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDC--RAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAA 76
A+ G V +DAL + C R +GRTP+ ++ + ++ A
Sbjct: 689 ALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDAN 748
Query: 77 VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
D G TAL AC GH V+LL++ + +A SP+ A + E L
Sbjct: 749 PATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNA-FSPLHCAVINDNEGAAEML 807
Query: 137 VRSFRRLGLRL-DRTNRAGLTALQLAAARGHGTCVQAL 173
+ + LG + + T+ G T L AA H C+Q L
Sbjct: 808 IDT---LGASIVNATDSKGRTPLHAAAFTDHVECLQLL 842
>gi|89941470 ankyrin repeat domain 34 [Homo sapiens]
Length = 496
Score = 74.3 bits (181), Expect = 2e-13
Identities = 75/220 (34%), Positives = 94/220 (42%), Gaps = 36/220 (16%)
Query: 17 LEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVA--VGLPDPALRARFVRLLLEQG 74
L A+ GK+ LAR +L+ + ++ QG T LM A DP +AR VR LLEQG
Sbjct: 10 LRAVGQGKLRLARLLLEG--GAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
Query: 75 AAVNLRDERGRTALSLACERGHLDAV-QLLVQFSGDPEAADSAGNSPVMWAAACGHGAVL 133
A N+ D GRTAL AC G AV LL+ DP D AG S ++ A
Sbjct: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHA--------- 118
Query: 134 EFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSDS 193
LDR +R L L L A + GT V +T + + NS
Sbjct: 119 -------------LDRGDRETLATL-LDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPP 164
Query: 194 PPG--RPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGG 231
PG PAPA+ PSP P + A GG G
Sbjct: 165 SPGVEDPAPAS------PSPGFCTSPSEIQLQTAGGGGRG 198
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 73.9 bits (180), Expect = 2e-13
Identities = 43/106 (40%), Positives = 59/106 (55%), Gaps = 4/106 (3%)
Query: 65 RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWA 124
+ VRLLLE+G VNL D++GRT L +A GHL V+ L+ + D G S + WA
Sbjct: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
Query: 125 AACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCV 170
GH AV+++LV G +D+T++ G T L LAA G V
Sbjct: 1178 CLKGHRAVVQYLVEE----GAAIDQTDKNGRTPLDLAAFYGDAETV 1219
Score = 65.1 bits (157), Expect = 1e-10
Identities = 45/127 (35%), Positives = 62/127 (48%), Gaps = 8/127 (6%)
Query: 47 GRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
G T L A G + LLL GAAV+ + RG L A +GH V+LL++
Sbjct: 1071 GETALTAAAGRG----KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLER 1126
Query: 107 SGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
D +D G +P+M AA GH + +EFL+ G L ++ GL+AL A +GH
Sbjct: 1127 GCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSK----GAALSSLDKEGLSALSWACLKGH 1182
Query: 167 GTCVQAL 173
VQ L
Sbjct: 1183 RAVVQYL 1189
Score = 60.8 bits (146), Expect = 2e-09
Identities = 54/182 (29%), Positives = 84/182 (46%), Gaps = 12/182 (6%)
Query: 10 RAGTRTFLEAMQAGKVHLARFVLD-ALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVR 68
R G A + G + R +L+ D ++ D +QGRTPLMVA + V
Sbjct: 1102 RRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD---KQGRTPLMVAACEGHLST----VE 1154
Query: 69 LLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACG 128
LL +GAA++ D+ G +ALS AC +GH VQ LV+ + D G +P+ AA G
Sbjct: 1155 FLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYG 1214
Query: 129 HGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARG 188
+ +LV G ++ + +G+ L A + + V AL + AA A
Sbjct: 1215 DAETVLYLVEK----GAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMA 1270
Query: 189 SN 190
++
Sbjct: 1271 TS 1272
Score = 54.7 bits (130), Expect = 1e-07
Identities = 45/137 (32%), Positives = 60/137 (43%), Gaps = 17/137 (12%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
V LLLE GA ++ E G TAL A GH+ V LL + + D G ++ +A
Sbjct: 943 VTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSAL 1002
Query: 127 CGHGAVLEFLVRSFRRLGLRLD---RTNRAGLTALQLAAARGHGTCVQALTGP------- 176
GHG +L++L+ G R + A AL AA+ GH + VQ L G
Sbjct: 1003 RGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVE 1062
Query: 177 -------WGRAAAAAAA 186
WG A AAA
Sbjct: 1063 VNGTDTLWGETALTAAA 1079
Score = 53.1 bits (126), Expect = 4e-07
Identities = 39/113 (34%), Positives = 57/113 (50%), Gaps = 7/113 (6%)
Query: 68 RLLLEQGAAVNLRDERGRTA--LSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
RLL+ GA VN R E A L + GH + V LL++F + G + + +AA
Sbjct: 909 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQ-ALTGPW 177
A GH ++ L + G+R+D ++ G AL +A RGHG +Q LT W
Sbjct: 969 AAGHMKLVCLLTKK----GVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEW 1017
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 73.9 bits (180), Expect = 2e-13
Identities = 43/106 (40%), Positives = 59/106 (55%), Gaps = 4/106 (3%)
Query: 65 RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWA 124
+ VRLLLE+G VNL D++GRT L +A GHL V+ L+ + D G S + WA
Sbjct: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
Query: 125 AACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCV 170
GH AV+++LV G +D+T++ G T L LAA G V
Sbjct: 1186 CLKGHRAVVQYLVEE----GAAIDQTDKNGRTPLDLAAFYGDAETV 1227
Score = 65.1 bits (157), Expect = 1e-10
Identities = 45/127 (35%), Positives = 62/127 (48%), Gaps = 8/127 (6%)
Query: 47 GRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
G T L A G + LLL GAAV+ + RG L A +GH V+LL++
Sbjct: 1079 GETALTAAAGRG----KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLER 1134
Query: 107 SGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
D +D G +P+M AA GH + +EFL+ G L ++ GL+AL A +GH
Sbjct: 1135 GCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSK----GAALSSLDKEGLSALSWACLKGH 1190
Query: 167 GTCVQAL 173
VQ L
Sbjct: 1191 RAVVQYL 1197
Score = 60.8 bits (146), Expect = 2e-09
Identities = 54/182 (29%), Positives = 84/182 (46%), Gaps = 12/182 (6%)
Query: 10 RAGTRTFLEAMQAGKVHLARFVLD-ALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVR 68
R G A + G + R +L+ D ++ D +QGRTPLMVA + V
Sbjct: 1110 RRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD---KQGRTPLMVAACEGHLST----VE 1162
Query: 69 LLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACG 128
LL +GAA++ D+ G +ALS AC +GH VQ LV+ + D G +P+ AA G
Sbjct: 1163 FLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYG 1222
Query: 129 HGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARG 188
+ +LV G ++ + +G+ L A + + V AL + AA A
Sbjct: 1223 DAETVLYLVEK----GAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMA 1278
Query: 189 SN 190
++
Sbjct: 1279 TS 1280
Score = 54.7 bits (130), Expect = 1e-07
Identities = 45/137 (32%), Positives = 60/137 (43%), Gaps = 17/137 (12%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
V LLLE GA ++ E G TAL A GH+ V LL + + D G ++ +A
Sbjct: 951 VTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSAL 1010
Query: 127 CGHGAVLEFLVRSFRRLGLRLD---RTNRAGLTALQLAAARGHGTCVQALTGP------- 176
GHG +L++L+ G R + A AL AA+ GH + VQ L G
Sbjct: 1011 RGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVE 1070
Query: 177 -------WGRAAAAAAA 186
WG A AAA
Sbjct: 1071 VNGTDTLWGETALTAAA 1087
Score = 53.1 bits (126), Expect = 4e-07
Identities = 39/113 (34%), Positives = 57/113 (50%), Gaps = 7/113 (6%)
Query: 68 RLLLEQGAAVNLRDERGRTA--LSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
RLL+ GA VN R E A L + GH + V LL++F + G + + +AA
Sbjct: 917 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQ-ALTGPW 177
A GH ++ L + G+R+D ++ G AL +A RGHG +Q LT W
Sbjct: 977 AAGHMKLVCLLTKK----GVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEW 1025
>gi|38257146 ankyrin repeat domain 46 [Homo sapiens]
Length = 228
Score = 70.5 bits (171), Expect = 2e-12
Identities = 43/100 (43%), Positives = 56/100 (56%), Gaps = 7/100 (7%)
Query: 66 FVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
+ + LLE G N+RD RGRT L LA RG++D QLL +F D A D GN+ +
Sbjct: 27 YSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL---H 83
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARG 165
CGH ++FLV + GL++D N G T L LA RG
Sbjct: 84 LCGHVDTIQFLVSN----GLKIDICNHQGATPLVLAKRRG 119
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 70.1 bits (170), Expect = 3e-12
Identities = 50/136 (36%), Positives = 67/136 (49%), Gaps = 17/136 (12%)
Query: 38 SIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHL 97
+++ C A++G P++ F+ LE A++ D+ GRTA A E G L
Sbjct: 126 TLLHCAAQKGHVPVLA------------FIMEDLED-VALDHVDKLGRTAFHRAAEHGQL 172
Query: 98 DAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTA 157
DA+ LV D D GN+ + AA GH AVL+ LV +GL L+ N GLTA
Sbjct: 173 DALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLV----DIGLDLEEQNAEGLTA 228
Query: 158 LQLAAARGHGTCVQAL 173
L AA H CVQ L
Sbjct: 229 LHSAAGGSHPDCVQLL 244
Score = 50.8 bits (120), Expect = 2e-06
Identities = 43/149 (28%), Positives = 69/149 (46%), Gaps = 12/149 (8%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAV--GLPDPALRARFVRLLLEQGAA 76
A Q G V + F+++ L+ +D + GRT A G D + L+ G
Sbjct: 131 AAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDA------LDFLVGSGCD 184
Query: 77 VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
N++D+ G TAL LA RGH+ +Q LV D E ++ G + + AA H ++ L
Sbjct: 185 HNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLL 244
Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAARG 165
+R+ G ++ + L+ L AA G
Sbjct: 245 LRA----GSTVNALTQKNLSCLHYAALSG 269
Score = 44.7 bits (104), Expect = 1e-04
Identities = 45/143 (31%), Positives = 58/143 (40%), Gaps = 16/143 (11%)
Query: 43 RAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGR----------TALSLAC 92
R GR L A G A + VRLLLE AAV+ D G AL L+
Sbjct: 44 RNHVGRVALHWAAG----AGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSA 99
Query: 93 ERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNR 152
GHL +Q+LV G + + AA GH VL F++ + LD ++
Sbjct: 100 WFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLE--DVALDHVDK 157
Query: 153 AGLTALQLAAARGHGTCVQALTG 175
G TA AA G + L G
Sbjct: 158 LGRTAFHRAAEHGQLDALDFLVG 180
Score = 44.3 bits (103), Expect = 2e-04
Identities = 30/96 (31%), Positives = 47/96 (48%), Gaps = 4/96 (4%)
Query: 46 QGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQ 105
QG +PL +AV PAL VRLL+ + VN D R +T L LA E D +L+
Sbjct: 290 QGASPLHLAVRHNFPAL----VRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLI 345
Query: 106 FSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFR 141
D D G + + A H ++++ ++++ R
Sbjct: 346 AGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADR 381
Score = 36.2 bits (82), Expect = 0.050
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 12/169 (7%)
Query: 6 DLCPRAGTRTFLEAMQAGKVHLARFVLDA-LDRSIIDCRAEQGRTPLMVAVGLPDPALRA 64
D + G F A + G++ F++ + D ++ D ++G T L +A G A+
Sbjct: 153 DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKD---KEGNTALHLAAGRGHMAVLQ 209
Query: 65 RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWA 124
R V + G + ++ G TAL A H D VQLL++ A S + +A
Sbjct: 210 RLVDI----GLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYA 265
Query: 125 AACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
A G V L+ + G + + G + L LA V+ L
Sbjct: 266 ALSGSEDVSRVLIHA----GGCANVVDHQGASPLHLAVRHNFPALVRLL 310
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 70.1 bits (170), Expect = 3e-12
Identities = 44/113 (38%), Positives = 60/113 (53%), Gaps = 10/113 (8%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
V+ LLE GA D++GRTAL A G+ VQLL+ DP D GN+P+ AA
Sbjct: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAAR------GHGTCVQAL 173
H V+ L+R G R+D +RAG T L LA ++ GH C++A+
Sbjct: 186 TNHVPVITTLLRG----GARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
Score = 39.7 bits (91), Expect = 0.005
Identities = 26/76 (34%), Positives = 37/76 (48%), Gaps = 6/76 (7%)
Query: 65 RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWA 124
+ V+LLL+ GA N RD G T L LA H+ + L++ +A D AG +P+ A
Sbjct: 157 QIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
Query: 125 AAC------GHGAVLE 134
+ GH LE
Sbjct: 217 KSKLNILQEGHAQCLE 232
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 69.7 bits (169), Expect = 4e-12
Identities = 51/168 (30%), Positives = 76/168 (45%), Gaps = 16/168 (9%)
Query: 14 RTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQ--------GRTPLMVAVGLPDPALRAR 65
+ + A G + ++LD ++ + Q G T L A G +
Sbjct: 993 QALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRG----KLE 1048
Query: 66 FVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
RLLLEQGAAV + RG L +GH V LL+ D AD G +P+M AA
Sbjct: 1049 VCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAA 1108
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
+ GH ++FL+ G + ++ GLTAL A +GH + V++L
Sbjct: 1109 SEGHLGTVDFLLAQ----GASIALMDKEGLTALSWACLKGHLSVVRSL 1152
Score = 65.1 bits (157), Expect = 1e-10
Identities = 44/117 (37%), Positives = 61/117 (52%), Gaps = 8/117 (6%)
Query: 45 EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLV 104
+QGRTPLM+A V LL QGA++ L D+ G TALS AC +GHL V+ LV
Sbjct: 1098 KQGRTPLMMAASEGHLGT----VDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLV 1153
Query: 105 QFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLA 161
+ AD G +P+ AA G V++FLV G ++ + +G+ L A
Sbjct: 1154 DNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDH----GAMIEHVDYSGMRPLDRA 1206
Score = 62.8 bits (151), Expect = 5e-10
Identities = 50/162 (30%), Positives = 70/162 (43%), Gaps = 10/162 (6%)
Query: 12 GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
G A GK+ + R +L+ + + +G PL V + V LLL
Sbjct: 1034 GETALTAAAGRGKLEVCRLLLE--QGAAVAQPNRRGAVPLFSTVRQG----HWQIVDLLL 1087
Query: 72 EQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGA 131
GA VN+ D++GRT L +A GHL V L+ D G + + WA GH +
Sbjct: 1088 THGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLS 1147
Query: 132 VLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
V+ LV + G D ++ G T L LAA G VQ L
Sbjct: 1148 VVRSLVDN----GAATDHADKNGRTPLDLAAFYGDAEVVQFL 1185
Score = 46.2 bits (108), Expect = 5e-05
Identities = 27/78 (34%), Positives = 41/78 (52%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
VR L++ GAA + D+ GRT L LA G + VQ LV E D +G P+ A
Sbjct: 1149 VRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVG 1208
Query: 127 CGHGAVLEFLVRSFRRLG 144
C + +V+ L++ ++G
Sbjct: 1209 CRNTSVVVTLLKKGAKIG 1226
Score = 42.7 bits (99), Expect = 5e-04
Identities = 27/72 (37%), Positives = 37/72 (51%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
V LLLE GA V+ E G T L A G+L V LL + + D G ++ AA
Sbjct: 901 VALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAAL 960
Query: 127 CGHGAVLEFLVR 138
GH V++FL++
Sbjct: 961 RGHLEVVKFLIQ 972
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 68.2 bits (165), Expect = 1e-11
Identities = 45/131 (34%), Positives = 66/131 (50%), Gaps = 5/131 (3%)
Query: 43 RAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQL 102
R ++G TPL VA +L + LL+ +GA VN D G T L LAC++G+ L
Sbjct: 459 RDDRGHTPLHVAAVCGQASL----IDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLL 514
Query: 103 LVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAA 162
L+ + E D+ GN+P+ A GH ++ LV + RLD N G T L +AA
Sbjct: 515 LLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALV-YYDVESCRLDIGNEKGDTPLHIAA 573
Query: 163 ARGHGTCVQAL 173
G+ ++ L
Sbjct: 574 RWGYQGVIETL 584
Score = 63.2 bits (152), Expect = 4e-10
Identities = 42/136 (30%), Positives = 69/136 (50%), Gaps = 12/136 (8%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPAL--RARFVRLLLEQGAAVNLRDERGRTALSLACERGHL 97
++ ++ G +PL VA AL RA + LLL+ GA R+ L LAC++GH
Sbjct: 737 VNVTSQDGSSPLHVA------ALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHF 790
Query: 98 DAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTA 157
V+ L+ + P D +GN+P+++A + GH ++ L++ G ++ +N G TA
Sbjct: 791 QVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQH----GASINASNNKGNTA 846
Query: 158 LQLAAARGHGTCVQAL 173
L A H V+ L
Sbjct: 847 LHEAVIEKHVFVVELL 862
Score = 43.1 bits (100), Expect = 4e-04
Identities = 25/71 (35%), Positives = 37/71 (52%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
V+ LL+ A N +D G T L AC GH + V LL+Q A+++ GN+ + A
Sbjct: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVI 852
Query: 127 CGHGAVLEFLV 137
H V+E L+
Sbjct: 853 EKHVFVVELLL 863
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 67.0 bits (162), Expect = 3e-11
Identities = 53/155 (34%), Positives = 77/155 (49%), Gaps = 9/155 (5%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
A + G + L + +L++ R +DCR G T LMVA A VR L+ QGA +N
Sbjct: 19 AARRGNLALLKLLLNS-GRVDVDCRDSHGTTLLMVAAY----AGHIDCVRELVLQGADIN 73
Query: 79 LRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVR 138
L+ E G TAL A ++GH D V+ L F E G + ++ A+ GH V+E L++
Sbjct: 74 LQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
Query: 139 SFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
G + G TAL LAA G+ ++ L
Sbjct: 134 H----GANIHDQLYDGATALFLAAQGGYLDVIRLL 164
Score = 51.6 bits (122), Expect = 1e-06
Identities = 46/163 (28%), Positives = 70/163 (42%), Gaps = 10/163 (6%)
Query: 11 AGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLL 70
+GT A Q G + RF+ + + R + G T L+ A + V L
Sbjct: 78 SGTTALFFAAQQGHNDVVRFLFGF--GASTEFRTKDGGTALLAASQYG----HMQVVETL 131
Query: 71 LEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
L+ GA ++ + G TAL LA + G+LD ++LL+ G +P+ A+ GH
Sbjct: 132 LKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHS 191
Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
V VR G D G TAL AA +G+ ++ L
Sbjct: 192 EV----VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKEL 230
Score = 45.8 bits (107), Expect = 6e-05
Identities = 30/100 (30%), Positives = 53/100 (53%), Gaps = 5/100 (5%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
+RLLL GA VN + G L +A + GH + V++++ D +AA + G + ++ AA
Sbjct: 161 IRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAAN 220
Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
G+ V++ L++ LG+ + G +AL A G+
Sbjct: 221 KGYNDVIKELLKFSPTLGIL-----KNGTSALHAAVLSGN 255
Score = 37.4 bits (85), Expect = 0.023
Identities = 31/87 (35%), Positives = 44/87 (50%), Gaps = 7/87 (8%)
Query: 91 ACERGHLDAVQLLVQFSG--DPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLD 148
A RG+L ++LL+ SG D + DS G + +M AA GH + LV G ++
Sbjct: 19 AARRGNLALLKLLLN-SGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQ----GADIN 73
Query: 149 RTNRAGLTALQLAAARGHGTCVQALTG 175
+G TAL AA +GH V+ L G
Sbjct: 74 LQRESGTTALFFAAQQGHNDVVRFLFG 100
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 66.6 bits (161), Expect = 3e-11
Identities = 48/140 (34%), Positives = 68/140 (48%), Gaps = 8/140 (5%)
Query: 46 QGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQ 105
+G+TPL VA +L V+LL QGA ++ + RT L LA ERG + A+Q L++
Sbjct: 493 EGKTPLHVAAYFGHVSL----VKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548
Query: 106 FSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARG 165
P+A D +G P+ AAA G + + L+ R G L+ G T L LAA +G
Sbjct: 549 SGAVPDALDQSGYGPLHTAAARGKYLICKMLL----RYGASLELPTHQGWTPLHLAAYKG 604
Query: 166 HGTCVQALTGPWGRAAAAAA 185
H + L A A
Sbjct: 605 HLEIIHLLAESHANMGALGA 624
Score = 59.3 bits (142), Expect = 6e-09
Identities = 46/163 (28%), Positives = 67/163 (41%), Gaps = 33/163 (20%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALRARFV-----------------------------RLL 70
+DC+ G TPL++A P L A + RLL
Sbjct: 388 VDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLL 447
Query: 71 LEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
L+ GA V+ ++ G T L LA + + +LLV DP ++ G +P+ AA GH
Sbjct: 448 LDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHV 507
Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
++++ L G LD R T L LA RG +Q L
Sbjct: 508 SLVKLLTSQ----GAELDAQQRNLRTPLHLAVERGKVRAIQHL 546
Score = 49.7 bits (117), Expect = 4e-06
Identities = 42/148 (28%), Positives = 72/148 (48%), Gaps = 14/148 (9%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFV--RLLLEQGAA 76
A++ GKV + +L + ++ D + G PL A A R +++ ++LL GA+
Sbjct: 534 AVERGKVRAIQHLLKS--GAVPDALDQSGYGPLHTA------AARGKYLICKMLLRYGAS 585
Query: 77 VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
+ L +G T L LA +GHL+ + LL + + A + +P+ AA G AV+ L
Sbjct: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAAR 164
+ + G + ++G T L LA R
Sbjct: 646 L----QCGADPNAAEQSGWTPLHLAVQR 669
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 66.6 bits (161), Expect = 3e-11
Identities = 43/129 (33%), Positives = 66/129 (51%), Gaps = 4/129 (3%)
Query: 10 RAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRL 69
+ G +EA G + R +LD D A + A+ + +F L
Sbjct: 1283 KTGLTPLMEAASGGYAEVGRVLLD----KGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1338
Query: 70 LLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGH 129
L+ +GA +++R+++G T L LA GHLD VQLLVQ D +AAD+ +P+M A GH
Sbjct: 1339 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1398
Query: 130 GAVLEFLVR 138
V+ +LV+
Sbjct: 1399 VKVVRYLVK 1407
Score = 65.9 bits (159), Expect = 6e-11
Identities = 44/128 (34%), Positives = 60/128 (46%), Gaps = 11/128 (8%)
Query: 53 VAVGLPDPALRA------RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
+ +G P + A V+ LL GA V+ G TAL+ ACE GH D +L+Q
Sbjct: 560 IELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQA 619
Query: 107 SGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTN-RAGLTALQLAAARG 165
D E G +P+M AA GH ++FL+ G ++RT T L LA A G
Sbjct: 620 GADLEHESEGGRTPLMKAARAGHVCTVQFLISK----GANVNRTTANNDHTVLSLACAGG 675
Query: 166 HGTCVQAL 173
H V+ L
Sbjct: 676 HLAVVELL 683
Score = 62.8 bits (151), Expect = 5e-10
Identities = 48/155 (30%), Positives = 76/155 (49%), Gaps = 8/155 (5%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
A AG LA+ +L A+ ++ D + TPLM A + V+LLL A VN
Sbjct: 274 ACSAGYYELAQVLL-AMHANVEDRGIKGDITPLMAAAN----GGHVKIVKLLLAHKADVN 328
Query: 79 LRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVR 138
+ G TAL+ AC G++D V++L++ E + G++P+M A + GH V L+
Sbjct: 329 AQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLE 388
Query: 139 SFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
+ + +N +AL LA +GH V+ L
Sbjct: 389 NGAGIN---THSNEFKESALTLACYKGHLEMVRFL 420
Score = 60.5 bits (145), Expect = 2e-09
Identities = 49/156 (31%), Positives = 73/156 (46%), Gaps = 11/156 (7%)
Query: 12 GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
G A G V + + +L++ + I+ E G TPLM A A RLLL
Sbjct: 334 GNTALTYACAGGYVDVVKVLLES--GASIEDHNENGHTPLMEA----GSAGHVEVARLLL 387
Query: 72 EQGAAVNLR-DERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
E GA +N +E +AL+LAC +GHL+ V+ L++ D E ++ +M A GH
Sbjct: 388 ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447
Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
V L+ S ++ + D + L LAA GH
Sbjct: 448 EVARLLLDSGAQVNMPADSFE----SPLTLAACGGH 479
Score = 58.5 bits (140), Expect = 9e-09
Identities = 41/135 (30%), Positives = 72/135 (53%), Gaps = 7/135 (5%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGR-TALSLACERGHLD 98
I+ R ++G TPL++A A V +LL+ GA + + ER + T LSLAC G +
Sbjct: 1109 IEHRDKKGFTPLILAA----TAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQE 1164
Query: 99 AVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTAL 158
V+LL+ + E + + +P+ AA+ G+ +++ L+ + + R ++ G++ L
Sbjct: 1165 VVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTG--SKLGISPL 1222
Query: 159 QLAAARGHGTCVQAL 173
LAA GH V+ L
Sbjct: 1223 MLAAMNGHTAAVKLL 1237
Score = 58.2 bits (139), Expect = 1e-08
Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 12/153 (7%)
Query: 23 GKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDE 82
G+ + +LD ++ ++ RA+ G TPLM A A R+LL++GA VN
Sbjct: 1263 GRTEVVSLLLDR--KANVEHRAKTGLTPLMEAAS----GGYAEVGRVLLDKGADVNAPPV 1316
Query: 83 RGR--TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSF 140
TAL++A ++GH +LL+ + + GN+P+ AA GH V++ LV++
Sbjct: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA- 1375
Query: 141 RRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
G +D + +T L A +GH V+ L
Sbjct: 1376 ---GADVDAADNRKITPLMAAFRKGHVKVVRYL 1405
Score = 53.9 bits (128), Expect = 2e-07
Identities = 43/123 (34%), Positives = 62/123 (50%), Gaps = 12/123 (9%)
Query: 45 EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLR-DERGRTALSLACERGHLDAVQLL 103
++G TPLM A + V LLL QGA +N + +E TAL+LAC G L+ L
Sbjct: 498 DEGYTPLMEAAREGHEEM----VALLLGQGANINAQTEETQETALTLACCGGFLEVADFL 553
Query: 104 VQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAA 163
++ D E S +P+M AA GH ++++L+ + G + T G TAL A
Sbjct: 554 IKAGADIELGCS---TPLMEAAQEGHLELVKYLLAA----GANVHATTATGDTALTYACE 606
Query: 164 RGH 166
GH
Sbjct: 607 NGH 609
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/108 (32%), Positives = 59/108 (54%), Gaps = 5/108 (4%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEA-ADSAGNSPVMWAA 125
V+ LLE+GA++ RD++G T L LA GH+ V++L+ D EA ++ ++P+ A
Sbjct: 1099 VQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLAC 1158
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
+ G V+E L+ G + N + T L LAA+ G+ ++ L
Sbjct: 1159 SGGRQEVVELLLAR----GANKEHRNVSDYTPLSLAASGGYVNIIKIL 1202
Score = 53.5 bits (127), Expect = 3e-07
Identities = 48/158 (30%), Positives = 78/158 (49%), Gaps = 7/158 (4%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
A G V++ + +L+A ++ G +PLM+A A V+LLL+ G+ +N
Sbjct: 1190 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAA----VKLLLDMGSDIN 1245
Query: 79 LRDERGR-TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLV 137
+ E R TAL+LAC +G + V LL+ + E G +P+M AA+ G+ V L+
Sbjct: 1246 AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1305
Query: 138 RSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTG 175
+ ++R TAL +AA +GH + L G
Sbjct: 1306 DKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIG 1341
Score = 51.6 bits (122), Expect = 1e-06
Identities = 42/127 (33%), Positives = 62/127 (48%), Gaps = 7/127 (5%)
Query: 12 GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
G A + G +A +L A + ++ +E GRTPLM A A V+ L+
Sbjct: 597 GDTALTYACENGHTDVADVLLQA--GADLEHESEGGRTPLMKAAR----AGHVCTVQFLI 650
Query: 72 EQGAAVNLRDERG-RTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
+GA VN T LSLAC GHL V+LL+ DP G++ ++ AA GH
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710
Query: 131 AVLEFLV 137
+V+ +L+
Sbjct: 711 SVVCYLL 717
Score = 49.7 bits (117), Expect = 4e-06
Identities = 41/147 (27%), Positives = 68/147 (46%), Gaps = 9/147 (6%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
A G + + RF+L+A + + + ++ T LM A RLLL+ GA VN
Sbjct: 408 ACYKGHLEMVRFLLEA--GADQEHKTDEMHTALMEAC----MDGHVEVARLLLDSGAQVN 461
Query: 79 LRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVR 138
+ + + L+LA GH++ LL++ E + G +P+M AA GH ++ L+
Sbjct: 462 MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG 521
Query: 139 SFRRLGLRLDRTNRAGLTALQLAAARG 165
+ + + T TAL LA G
Sbjct: 522 QGANINAQTEETQE---TALTLACCGG 545
Score = 48.9 bits (115), Expect = 7e-06
Identities = 35/107 (32%), Positives = 52/107 (48%), Gaps = 14/107 (13%)
Query: 86 TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGL 145
TAL+LAC GH + VQ L++ E D G +P++ AA GH V+E L+ + +
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 146 RLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSD 192
+ +RT T L LA + G V+ L ARG+N +
Sbjct: 1145 QSERTKD---TPLSLACSGGRQEVVELL-----------LARGANKE 1177
Score = 46.6 bits (109), Expect = 4e-05
Identities = 34/108 (31%), Positives = 54/108 (50%), Gaps = 5/108 (4%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGN-SPVMWAA 125
VR LL +G +VN E G + L LAC G+ + Q+L+ + E G+ +P+M AA
Sbjct: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
GH +++ L+ ++ + G TAL A A G+ V+ L
Sbjct: 310 NGGHVKIVKLLLAH----KADVNAQSSTGNTALTYACAGGYVDVVKVL 353
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 66.6 bits (161), Expect = 3e-11
Identities = 43/129 (33%), Positives = 66/129 (51%), Gaps = 4/129 (3%)
Query: 10 RAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRL 69
+ G +EA G + R +LD D A + A+ + +F L
Sbjct: 1032 KTGLTPLMEAASGGYAEVGRVLLD----KGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1087
Query: 70 LLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGH 129
L+ +GA +++R+++G T L LA GHLD VQLLVQ D +AAD+ +P+M A GH
Sbjct: 1088 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1147
Query: 130 GAVLEFLVR 138
V+ +LV+
Sbjct: 1148 VKVVRYLVK 1156
Score = 65.9 bits (159), Expect = 6e-11
Identities = 44/128 (34%), Positives = 60/128 (46%), Gaps = 11/128 (8%)
Query: 53 VAVGLPDPALRA------RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
+ +G P + A V+ LL GA V+ G TAL+ ACE GH D +L+Q
Sbjct: 560 IELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQA 619
Query: 107 SGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTN-RAGLTALQLAAARG 165
D E G +P+M AA GH ++FL+ G ++RT T L LA A G
Sbjct: 620 GADLEHESEGGRTPLMKAARAGHVCTVQFLISK----GANVNRTTANNDHTVLSLACAGG 675
Query: 166 HGTCVQAL 173
H V+ L
Sbjct: 676 HLAVVELL 683
Score = 62.8 bits (151), Expect = 5e-10
Identities = 48/155 (30%), Positives = 76/155 (49%), Gaps = 8/155 (5%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
A AG LA+ +L A+ ++ D + TPLM A + V+LLL A VN
Sbjct: 274 ACSAGYYELAQVLL-AMHANVEDRGIKGDITPLMAAAN----GGHVKIVKLLLAHKADVN 328
Query: 79 LRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVR 138
+ G TAL+ AC G++D V++L++ E + G++P+M A + GH V L+
Sbjct: 329 AQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLE 388
Query: 139 SFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
+ + +N +AL LA +GH V+ L
Sbjct: 389 NGAGIN---THSNEFKESALTLACYKGHLEMVRFL 420
Score = 60.5 bits (145), Expect = 2e-09
Identities = 49/156 (31%), Positives = 73/156 (46%), Gaps = 11/156 (7%)
Query: 12 GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
G A G V + + +L++ + I+ E G TPLM A A RLLL
Sbjct: 334 GNTALTYACAGGYVDVVKVLLES--GASIEDHNENGHTPLMEA----GSAGHVEVARLLL 387
Query: 72 EQGAAVNLR-DERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
E GA +N +E +AL+LAC +GHL+ V+ L++ D E ++ +M A GH
Sbjct: 388 ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447
Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
V L+ S ++ + D + L LAA GH
Sbjct: 448 EVARLLLDSGAQVNMPADSFE----SPLTLAACGGH 479
Score = 58.5 bits (140), Expect = 9e-09
Identities = 41/135 (30%), Positives = 72/135 (53%), Gaps = 7/135 (5%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGR-TALSLACERGHLD 98
I+ R ++G TPL++A A V +LL+ GA + + ER + T LSLAC G +
Sbjct: 858 IEHRDKKGFTPLILAA----TAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQE 913
Query: 99 AVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTAL 158
V+LL+ + E + + +P+ AA+ G+ +++ L+ + + R ++ G++ L
Sbjct: 914 VVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTG--SKLGISPL 971
Query: 159 QLAAARGHGTCVQAL 173
LAA GH V+ L
Sbjct: 972 MLAAMNGHTAAVKLL 986
Score = 58.2 bits (139), Expect = 1e-08
Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 12/153 (7%)
Query: 23 GKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDE 82
G+ + +LD ++ ++ RA+ G TPLM A A R+LL++GA VN
Sbjct: 1012 GRTEVVSLLLDR--KANVEHRAKTGLTPLMEAAS----GGYAEVGRVLLDKGADVNAPPV 1065
Query: 83 RGR--TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSF 140
TAL++A ++GH +LL+ + + GN+P+ AA GH V++ LV++
Sbjct: 1066 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA- 1124
Query: 141 RRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
G +D + +T L A +GH V+ L
Sbjct: 1125 ---GADVDAADNRKITPLMAAFRKGHVKVVRYL 1154
Score = 53.9 bits (128), Expect = 2e-07
Identities = 43/123 (34%), Positives = 62/123 (50%), Gaps = 12/123 (9%)
Query: 45 EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLR-DERGRTALSLACERGHLDAVQLL 103
++G TPLM A + V LLL QGA +N + +E TAL+LAC G L+ L
Sbjct: 498 DEGYTPLMEAAREGHEEM----VALLLGQGANINAQTEETQETALTLACCGGFLEVADFL 553
Query: 104 VQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAA 163
++ D E S +P+M AA GH ++++L+ + G + T G TAL A
Sbjct: 554 IKAGADIELGCS---TPLMEAAQEGHLELVKYLLAA----GANVHATTATGDTALTYACE 606
Query: 164 RGH 166
GH
Sbjct: 607 NGH 609
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/108 (32%), Positives = 59/108 (54%), Gaps = 5/108 (4%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEA-ADSAGNSPVMWAA 125
V+ LLE+GA++ RD++G T L LA GH+ V++L+ D EA ++ ++P+ A
Sbjct: 848 VQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLAC 907
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
+ G V+E L+ G + N + T L LAA+ G+ ++ L
Sbjct: 908 SGGRQEVVELLLAR----GANKEHRNVSDYTPLSLAASGGYVNIIKIL 951
Score = 53.5 bits (127), Expect = 3e-07
Identities = 48/158 (30%), Positives = 78/158 (49%), Gaps = 7/158 (4%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
A G V++ + +L+A ++ G +PLM+A A V+LLL+ G+ +N
Sbjct: 939 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAA----VKLLLDMGSDIN 994
Query: 79 LRDERGR-TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLV 137
+ E R TAL+LAC +G + V LL+ + E G +P+M AA+ G+ V L+
Sbjct: 995 AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1054
Query: 138 RSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTG 175
+ ++R TAL +AA +GH + L G
Sbjct: 1055 DKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIG 1090
Score = 51.6 bits (122), Expect = 1e-06
Identities = 42/127 (33%), Positives = 62/127 (48%), Gaps = 7/127 (5%)
Query: 12 GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
G A + G +A +L A + ++ +E GRTPLM A A V+ L+
Sbjct: 597 GDTALTYACENGHTDVADVLLQA--GADLEHESEGGRTPLMKAAR----AGHVCTVQFLI 650
Query: 72 EQGAAVNLRDERG-RTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
+GA VN T LSLAC GHL V+LL+ DP G++ ++ AA GH
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710
Query: 131 AVLEFLV 137
+V+ +L+
Sbjct: 711 SVVCYLL 717
Score = 49.7 bits (117), Expect = 4e-06
Identities = 41/147 (27%), Positives = 68/147 (46%), Gaps = 9/147 (6%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
A G + + RF+L+A + + + ++ T LM A RLLL+ GA VN
Sbjct: 408 ACYKGHLEMVRFLLEA--GADQEHKTDEMHTALMEAC----MDGHVEVARLLLDSGAQVN 461
Query: 79 LRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVR 138
+ + + L+LA GH++ LL++ E + G +P+M AA GH ++ L+
Sbjct: 462 MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG 521
Query: 139 SFRRLGLRLDRTNRAGLTALQLAAARG 165
+ + + T TAL LA G
Sbjct: 522 QGANINAQTEETQE---TALTLACCGG 545
Score = 48.9 bits (115), Expect = 7e-06
Identities = 35/107 (32%), Positives = 52/107 (48%), Gaps = 14/107 (13%)
Query: 86 TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGL 145
TAL+LAC GH + VQ L++ E D G +P++ AA GH V+E L+ + +
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Query: 146 RLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSD 192
+ +RT T L LA + G V+ L ARG+N +
Sbjct: 894 QSERTKD---TPLSLACSGGRQEVVELL-----------LARGANKE 926
Score = 46.6 bits (109), Expect = 4e-05
Identities = 34/108 (31%), Positives = 54/108 (50%), Gaps = 5/108 (4%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGN-SPVMWAA 125
VR LL +G +VN E G + L LAC G+ + Q+L+ + E G+ +P+M AA
Sbjct: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
GH +++ L+ ++ + G TAL A A G+ V+ L
Sbjct: 310 NGGHVKIVKLLLAH----KADVNAQSSTGNTALTYACAGGYVDVVKVL 353
>gi|169167742 PREDICTED: ankyrin repeat domain 33B [Homo sapiens]
Length = 494
Score = 66.2 bits (160), Expect = 5e-11
Identities = 86/315 (27%), Positives = 124/315 (39%), Gaps = 28/315 (8%)
Query: 67 VRLLLEQGAAVNLR---DERGRTALSLACERGHLDAVQLLVQFSG-DPEAADSAGNSPVM 122
+R L+ +G +V D GRT L +AC G +D V L + D DS GN+ ++
Sbjct: 101 LRTLVRRGVSVEEAQETDRNGRTGLIVACYHGFVDTVVALAECPHVDVNWQDSEGNTALI 160
Query: 123 WAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAA 182
AA GH + +L+ F GL L+R N G TAL AA +G C++AL A
Sbjct: 161 TAAQAGHAIITNYLLNYFP--GLDLERRNAFGFTALMKAAMQGRTDCIRALMLAGADVHA 218
Query: 183 AAAARGSNSD---SPPGRPAPAASPEH--RRPSPRRL---PRPLLARFARAAGGHGGEAG 234
RG + + GR + RP P + RP L AA G
Sbjct: 219 RDPRRGMSPQEWATYTGRVDAVRLMQRLLERPCPEQFWEKYRPELPPPPEAARKPAGSKN 278
Query: 235 SAGKNSGRHRAQGSER----PELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTG 290
+ + + + R PE G + + T + + P SP S G
Sbjct: 279 CLQRLTDCVLSVLTPRSVRGPEDGGVLDHMVRMTTSLYSPAVAIVCQTVCPESPPSVGKR 338
Query: 291 RWRSQEVLEGAPPTLAQAPIGLSPHPEGGPGS-GRLG-----LRRRSTAPDIPSLVGEAP 344
R QE+L A+ P GG G GR G R S +P +G +
Sbjct: 339 RLAVQEILAA---RAARGPQAQEEDEVGGAGQRGRTGQEDADSREGSPRAGLPPALG-SR 394
Query: 345 GPESGPELEANALPV 359
GP + +A+ LP+
Sbjct: 395 GPAAPAPRKASLLPL 409
>gi|113416996 PREDICTED: ankyrin repeat domain 33B [Homo sapiens]
Length = 1006
Score = 66.2 bits (160), Expect = 5e-11
Identities = 86/315 (27%), Positives = 124/315 (39%), Gaps = 28/315 (8%)
Query: 67 VRLLLEQGAAVNLR---DERGRTALSLACERGHLDAVQLLVQFSG-DPEAADSAGNSPVM 122
+R L+ +G +V D GRT L +AC G +D V L + D DS GN+ ++
Sbjct: 613 LRTLVRRGVSVEEAQETDRNGRTGLIVACYHGFVDTVVALAECPHVDVNWQDSEGNTALI 672
Query: 123 WAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAA 182
AA GH + +L+ F GL L+R N G TAL AA +G C++AL A
Sbjct: 673 TAAQAGHAIITNYLLNYFP--GLDLERRNAFGFTALMKAAMQGRTDCIRALMLAGADVHA 730
Query: 183 AAAARGSNSD---SPPGRPAPAASPEH--RRPSPRRL---PRPLLARFARAAGGHGGEAG 234
RG + + GR + RP P + RP L AA G
Sbjct: 731 RDPRRGMSPQEWATYTGRVDAVRLMQRLLERPCPEQFWEKYRPELPPPPEAARKPAGSKN 790
Query: 235 SAGKNSGRHRAQGSER----PELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTG 290
+ + + + R PE G + + T + + P SP S G
Sbjct: 791 CLQRLTDCVLSVLTPRSVRGPEDGGVLDHMVRMTTSLYSPAVAIVCQTVCPESPPSVGKR 850
Query: 291 RWRSQEVLEGAPPTLAQAPIGLSPHPEGGPGS-GRLG-----LRRRSTAPDIPSLVGEAP 344
R QE+L A+ P GG G GR G R S +P +G +
Sbjct: 851 RLAVQEILAA---RAARGPQAQEEDEVGGAGQRGRTGQEDADSREGSPRAGLPPALG-SR 906
Query: 345 GPESGPELEANALPV 359
GP + +A+ LP+
Sbjct: 907 GPAAPAPRKASLLPL 921
Score = 39.3 bits (90), Expect = 0.006
Identities = 56/187 (29%), Positives = 74/187 (39%), Gaps = 31/187 (16%)
Query: 178 GRAAAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAG----GHGGEA 233
GR +A R D PP A+ PE + + L RP R + A G G G
Sbjct: 187 GRERTSAPLR---RDLPPRLAHDASYPEVKGSLWQILTRPPPPRPSPAPGLTGRGQGRAR 243
Query: 234 GSAGKNSG-RHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRW 292
G+ G + G R R +P++G + S +L + R R +P S Q S GR
Sbjct: 244 GAVGLDCGCRPRPCSFGQPDVGSAPSRSLRGCS----LRFR-NTPPPIPGSDQPSSHGRP 298
Query: 293 RSQEVLE---------GAPPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEA 343
R +E + G PP AP P P+ PG+G R TAP L A
Sbjct: 299 RFRETGDSEDCPPFRAGTPPQQPTAPSSEWPGPQRSPGTG-----PRWTAP----LPRPA 349
Query: 344 PGPESGP 350
P P P
Sbjct: 350 PLPAKRP 356
>gi|239742483 PREDICTED: ankyrin repeat domain 33B [Homo sapiens]
Length = 494
Score = 66.2 bits (160), Expect = 5e-11
Identities = 86/315 (27%), Positives = 124/315 (39%), Gaps = 28/315 (8%)
Query: 67 VRLLLEQGAAVNLR---DERGRTALSLACERGHLDAVQLLVQFSG-DPEAADSAGNSPVM 122
+R L+ +G +V D GRT L +AC G +D V L + D DS GN+ ++
Sbjct: 101 LRTLVRRGVSVEEAQETDRNGRTGLIVACYHGFVDTVVALAECPHVDVNWQDSEGNTALI 160
Query: 123 WAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAA 182
AA GH + +L+ F GL L+R N G TAL AA +G C++AL A
Sbjct: 161 TAAQAGHAIITNYLLNYFP--GLDLERRNAFGFTALMKAAMQGRTDCIRALMLAGADVHA 218
Query: 183 AAAARGSNSD---SPPGRPAPAASPEH--RRPSPRRL---PRPLLARFARAAGGHGGEAG 234
RG + + GR + RP P + RP L AA G
Sbjct: 219 RDPRRGMSPQEWATYTGRVDAVRLMQRLLERPCPEQFWEKYRPELPPPPEAARKPAGSKN 278
Query: 235 SAGKNSGRHRAQGSER----PELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTG 290
+ + + + R PE G + + T + + P SP S G
Sbjct: 279 CLQRLTDCVLSVLTPRSVRGPEDGGVLDHMVRMTTSLYSPAVAIVCQTVCPESPPSVGKR 338
Query: 291 RWRSQEVLEGAPPTLAQAPIGLSPHPEGGPGS-GRLG-----LRRRSTAPDIPSLVGEAP 344
R QE+L A+ P GG G GR G R S +P +G +
Sbjct: 339 RLAVQEILAA---RAARGPQAQEEDEVGGAGQRGRTGQEDADSREGSPRAGLPPALG-SR 394
Query: 345 GPESGPELEANALPV 359
GP + +A+ LP+
Sbjct: 395 GPAAPAPRKASLLPL 409
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 66.2 bits (160), Expect = 5e-11
Identities = 42/129 (32%), Positives = 66/129 (51%), Gaps = 4/129 (3%)
Query: 10 RAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRL 69
+ G +EA G + R +LD D A + A+ + +F L
Sbjct: 1255 KTGLTPLMEAASGGYAEVGRVLLD----KGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1310
Query: 70 LLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGH 129
L+ +GA +++R+++G T L LA GH D VQLLVQ D +AAD+ +P+M A GH
Sbjct: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGH 1370
Query: 130 GAVLEFLVR 138
V+++LV+
Sbjct: 1371 VKVVQYLVK 1379
Score = 63.9 bits (154), Expect = 2e-10
Identities = 43/128 (33%), Positives = 60/128 (46%), Gaps = 11/128 (8%)
Query: 53 VAVGLPDPALRA------RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
+ +G P + A V+ LL GA V+ G TAL+ ACE GH D +L+Q
Sbjct: 531 IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 590
Query: 107 SGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDR-TNRAGLTALQLAAARG 165
D E G +P+M AA GH ++FL+ G ++R T T + LA A G
Sbjct: 591 GADLEHESEGGRTPLMKAARAGHLCTVQFLISK----GANVNRATANNDHTVVSLACAGG 646
Query: 166 HGTCVQAL 173
H V+ L
Sbjct: 647 HLAVVELL 654
Score = 60.1 bits (144), Expect = 3e-09
Identities = 48/156 (30%), Positives = 73/156 (46%), Gaps = 11/156 (7%)
Query: 12 GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
G A G V + + +L+ + + I+ E G TPLM A A R+LL
Sbjct: 305 GNTALTYACAGGFVDIVKVLLN--EGANIEDHNENGHTPLMEAAS----AGHVEVARVLL 358
Query: 72 EQGAAVNLR-DERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
+ GA +N +E +AL+LAC +GHLD V+ L++ D E ++ +M A GH
Sbjct: 359 DHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418
Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
V L+ S ++ + D + L LAA GH
Sbjct: 419 EVARLLLDSGAQVNMPADSFE----SPLTLAACGGH 450
Score = 59.3 bits (142), Expect = 6e-09
Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 12/153 (7%)
Query: 23 GKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDE 82
G+ + +LD ++ ++ RA+ G TPLM A A R+LL++GA VN
Sbjct: 1235 GRAEVVSLLLDR--KANVEHRAKTGLTPLMEAAS----GGYAEVGRVLLDKGADVNAPPV 1288
Query: 83 RGR--TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSF 140
TAL++A ++GH +LL+ + + GN+P+ A+ GH V++ LV++
Sbjct: 1289 PSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA- 1347
Query: 141 RRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
G +D + +T L A +GH VQ L
Sbjct: 1348 ---GADVDAADNRKITPLMSAFRKGHVKVVQYL 1377
Score = 55.8 bits (133), Expect = 6e-08
Identities = 51/157 (32%), Positives = 76/157 (48%), Gaps = 12/157 (7%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAV--GLPDPALRARFVRLLLEQGAA 76
A AG LA+ +L A+ ++ D + TPLM A G D V+LLL A
Sbjct: 245 ACSAGYYELAQVLL-AMHANVEDRGNKGDITPLMAASSGGYLD------IVKLLLLHDAD 297
Query: 77 VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
VN + G TAL+ AC G +D V++L+ + E + G++P+M AA+ GH V L
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 357
Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
+ + +N +AL LA +GH V+ L
Sbjct: 358 LDHGAGIN---THSNEFKESALTLACYKGHLDMVRFL 391
Score = 55.8 bits (133), Expect = 6e-08
Identities = 40/135 (29%), Positives = 71/135 (52%), Gaps = 7/135 (5%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGR-TALSLACERGHLD 98
I+ R ++G TPL++A A V +LL++G + + ER + T LSLAC G +
Sbjct: 1081 IEHRDKKGFTPLILAA----TAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 1136
Query: 99 AVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTAL 158
V LL+ + E + + +P+ AA+ G+ +++ L+ + + R ++ G++ L
Sbjct: 1137 VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTG--SKLGISPL 1194
Query: 159 QLAAARGHGTCVQAL 173
LAA GH V+ L
Sbjct: 1195 MLAAMNGHVPAVKLL 1209
Score = 52.0 bits (123), Expect = 9e-07
Identities = 42/123 (34%), Positives = 61/123 (49%), Gaps = 12/123 (9%)
Query: 45 EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLR-DERGRTALSLACERGHLDAVQLL 103
++G TPLM A + V LLL QGA +N + +E TAL+LAC G + L
Sbjct: 469 DEGYTPLMEAAREGHEEM----VALLLAQGANINAQTEETQETALTLACCGGFSEVADFL 524
Query: 104 VQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAA 163
++ D E S +P+M A+ GH ++++L+ S G + T G TAL A
Sbjct: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLAS----GANVHATTATGDTALTYACE 577
Query: 164 RGH 166
GH
Sbjct: 578 NGH 580
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/151 (30%), Positives = 76/151 (50%), Gaps = 11/151 (7%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARF--VRLLLEQGAA 76
A G V++ + +L+A ++ G +PLM+A A+ V+LLL+ G+
Sbjct: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA------AMNGHVPAVKLLLDMGSD 1215
Query: 77 VNLRDERGR-TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEF 135
+N + E R TAL+LAC +G + V LL+ + E G +P+M AA+ G+ V
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275
Query: 136 LVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
L+ + ++R TAL +AA +GH
Sbjct: 1276 LLDKGADVNAPPVPSSRD--TALTIAADKGH 1304
Score = 50.4 bits (119), Expect = 3e-06
Identities = 45/182 (24%), Positives = 75/182 (41%), Gaps = 31/182 (17%)
Query: 12 GTRTFLEAMQAGKVHLARFVLDA--------------------------LDRSIIDCRAE 45
G +EA AG V +AR +LD + R +++ A+
Sbjct: 338 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGAD 397
Query: 46 QGRTPLMVAVGLPDPAL--RARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLL 103
Q + L + + RLLL+ GA VN+ + + L+LA GH++ LL
Sbjct: 398 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457
Query: 104 VQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAA 163
++ + E + G +P+M AA GH ++ L+ + + + T TAL LA
Sbjct: 458 IERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE---TALTLACC 514
Query: 164 RG 165
G
Sbjct: 515 GG 516
Score = 50.4 bits (119), Expect = 3e-06
Identities = 41/127 (32%), Positives = 61/127 (48%), Gaps = 7/127 (5%)
Query: 12 GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
G A + G +A +L A + ++ +E GRTPLM A A V+ L+
Sbjct: 568 GDTALTYACENGHTDVADVLLQA--GADLEHESEGGRTPLMKAAR----AGHLCTVQFLI 621
Query: 72 EQGAAVNLRDERG-RTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
+GA VN T +SLAC GHL V+LL+ DP G++ ++ AA GH
Sbjct: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681
Query: 131 AVLEFLV 137
V+ +L+
Sbjct: 682 NVVSYLL 688
Score = 48.5 bits (114), Expect = 1e-05
Identities = 32/108 (29%), Positives = 57/108 (52%), Gaps = 5/108 (4%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEA-ADSAGNSPVMWAA 125
V +L+ + A + RD++G T L LA GH+ V++L+ GD EA ++ ++P+ A
Sbjct: 1071 VSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
+ G V++ L+ G + N + T L LAA+ G+ ++ L
Sbjct: 1131 SGGRQEVVDLLLAR----GANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
Score = 45.4 bits (106), Expect = 8e-05
Identities = 32/108 (29%), Positives = 56/108 (51%), Gaps = 5/108 (4%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGN-SPVMWAA 125
VR LL++G +VN E G + L LAC G+ + Q+L+ + E + G+ +P+M A+
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
+ G+ +++ L+ ++ + G TAL A A G V+ L
Sbjct: 281 SGGYLDIVKLLLLH----DADVNSQSATGNTALTYACAGGFVDIVKVL 324
Score = 45.4 bits (106), Expect = 8e-05
Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 14/107 (13%)
Query: 86 TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGL 145
TAL+LAC GH + V +L+ E D G +P++ AA GH V+E L+ +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 146 RLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSD 192
+ +RT T L LA + G V L ARG+N +
Sbjct: 1117 QSERTKD---TPLSLACSGGRQEVVDLL-----------LARGANKE 1149
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 66.2 bits (160), Expect = 5e-11
Identities = 42/129 (32%), Positives = 66/129 (51%), Gaps = 4/129 (3%)
Query: 10 RAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRL 69
+ G +EA G + R +LD D A + A+ + +F L
Sbjct: 1255 KTGLTPLMEAASGGYAEVGRVLLD----KGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1310
Query: 70 LLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGH 129
L+ +GA +++R+++G T L LA GH D VQLLVQ D +AAD+ +P+M A GH
Sbjct: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGH 1370
Query: 130 GAVLEFLVR 138
V+++LV+
Sbjct: 1371 VKVVQYLVK 1379
Score = 63.9 bits (154), Expect = 2e-10
Identities = 43/128 (33%), Positives = 60/128 (46%), Gaps = 11/128 (8%)
Query: 53 VAVGLPDPALRA------RFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
+ +G P + A V+ LL GA V+ G TAL+ ACE GH D +L+Q
Sbjct: 531 IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 590
Query: 107 SGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDR-TNRAGLTALQLAAARG 165
D E G +P+M AA GH ++FL+ G ++R T T + LA A G
Sbjct: 591 GADLEHESEGGRTPLMKAARAGHLCTVQFLISK----GANVNRATANNDHTVVSLACAGG 646
Query: 166 HGTCVQAL 173
H V+ L
Sbjct: 647 HLAVVELL 654
Score = 60.1 bits (144), Expect = 3e-09
Identities = 48/156 (30%), Positives = 73/156 (46%), Gaps = 11/156 (7%)
Query: 12 GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
G A G V + + +L+ + + I+ E G TPLM A A R+LL
Sbjct: 305 GNTALTYACAGGFVDIVKVLLN--EGANIEDHNENGHTPLMEAAS----AGHVEVARVLL 358
Query: 72 EQGAAVNLR-DERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
+ GA +N +E +AL+LAC +GHLD V+ L++ D E ++ +M A GH
Sbjct: 359 DHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418
Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
V L+ S ++ + D + L LAA GH
Sbjct: 419 EVARLLLDSGAQVNMPADSFE----SPLTLAACGGH 450
Score = 59.3 bits (142), Expect = 6e-09
Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 12/153 (7%)
Query: 23 GKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDE 82
G+ + +LD ++ ++ RA+ G TPLM A A R+LL++GA VN
Sbjct: 1235 GRAEVVSLLLDR--KANVEHRAKTGLTPLMEAAS----GGYAEVGRVLLDKGADVNAPPV 1288
Query: 83 RGR--TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSF 140
TAL++A ++GH +LL+ + + GN+P+ A+ GH V++ LV++
Sbjct: 1289 PSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA- 1347
Query: 141 RRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
G +D + +T L A +GH VQ L
Sbjct: 1348 ---GADVDAADNRKITPLMSAFRKGHVKVVQYL 1377
Score = 55.8 bits (133), Expect = 6e-08
Identities = 51/157 (32%), Positives = 76/157 (48%), Gaps = 12/157 (7%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAV--GLPDPALRARFVRLLLEQGAA 76
A AG LA+ +L A+ ++ D + TPLM A G D V+LLL A
Sbjct: 245 ACSAGYYELAQVLL-AMHANVEDRGNKGDITPLMAASSGGYLD------IVKLLLLHDAD 297
Query: 77 VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
VN + G TAL+ AC G +D V++L+ + E + G++P+M AA+ GH V L
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 357
Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
+ + +N +AL LA +GH V+ L
Sbjct: 358 LDHGAGIN---THSNEFKESALTLACYKGHLDMVRFL 391
Score = 55.8 bits (133), Expect = 6e-08
Identities = 40/135 (29%), Positives = 71/135 (52%), Gaps = 7/135 (5%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGR-TALSLACERGHLD 98
I+ R ++G TPL++A A V +LL++G + + ER + T LSLAC G +
Sbjct: 1081 IEHRDKKGFTPLILAA----TAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 1136
Query: 99 AVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTAL 158
V LL+ + E + + +P+ AA+ G+ +++ L+ + + R ++ G++ L
Sbjct: 1137 VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTG--SKLGISPL 1194
Query: 159 QLAAARGHGTCVQAL 173
LAA GH V+ L
Sbjct: 1195 MLAAMNGHVPAVKLL 1209
Score = 52.0 bits (123), Expect = 9e-07
Identities = 42/123 (34%), Positives = 61/123 (49%), Gaps = 12/123 (9%)
Query: 45 EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLR-DERGRTALSLACERGHLDAVQLL 103
++G TPLM A + V LLL QGA +N + +E TAL+LAC G + L
Sbjct: 469 DEGYTPLMEAAREGHEEM----VALLLAQGANINAQTEETQETALTLACCGGFSEVADFL 524
Query: 104 VQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAA 163
++ D E S +P+M A+ GH ++++L+ S G + T G TAL A
Sbjct: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLAS----GANVHATTATGDTALTYACE 577
Query: 164 RGH 166
GH
Sbjct: 578 NGH 580
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/151 (30%), Positives = 76/151 (50%), Gaps = 11/151 (7%)
Query: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARF--VRLLLEQGAA 76
A G V++ + +L+A ++ G +PLM+A A+ V+LLL+ G+
Sbjct: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA------AMNGHVPAVKLLLDMGSD 1215
Query: 77 VNLRDERGR-TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEF 135
+N + E R TAL+LAC +G + V LL+ + E G +P+M AA+ G+ V
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275
Query: 136 LVRSFRRLGLRLDRTNRAGLTALQLAAARGH 166
L+ + ++R TAL +AA +GH
Sbjct: 1276 LLDKGADVNAPPVPSSRD--TALTIAADKGH 1304
Score = 50.4 bits (119), Expect = 3e-06
Identities = 45/182 (24%), Positives = 75/182 (41%), Gaps = 31/182 (17%)
Query: 12 GTRTFLEAMQAGKVHLARFVLDA--------------------------LDRSIIDCRAE 45
G +EA AG V +AR +LD + R +++ A+
Sbjct: 338 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGAD 397
Query: 46 QGRTPLMVAVGLPDPAL--RARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLL 103
Q + L + + RLLL+ GA VN+ + + L+LA GH++ LL
Sbjct: 398 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457
Query: 104 VQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAA 163
++ + E + G +P+M AA GH ++ L+ + + + T TAL LA
Sbjct: 458 IERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE---TALTLACC 514
Query: 164 RG 165
G
Sbjct: 515 GG 516
Score = 50.4 bits (119), Expect = 3e-06
Identities = 41/127 (32%), Positives = 61/127 (48%), Gaps = 7/127 (5%)
Query: 12 GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
G A + G +A +L A + ++ +E GRTPLM A A V+ L+
Sbjct: 568 GDTALTYACENGHTDVADVLLQA--GADLEHESEGGRTPLMKAAR----AGHLCTVQFLI 621
Query: 72 EQGAAVNLRDERG-RTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
+GA VN T +SLAC GHL V+LL+ DP G++ ++ AA GH
Sbjct: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681
Query: 131 AVLEFLV 137
V+ +L+
Sbjct: 682 NVVSYLL 688
Score = 48.5 bits (114), Expect = 1e-05
Identities = 32/108 (29%), Positives = 57/108 (52%), Gaps = 5/108 (4%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEA-ADSAGNSPVMWAA 125
V +L+ + A + RD++G T L LA GH+ V++L+ GD EA ++ ++P+ A
Sbjct: 1071 VSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
+ G V++ L+ G + N + T L LAA+ G+ ++ L
Sbjct: 1131 SGGRQEVVDLLLAR----GANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
Score = 45.4 bits (106), Expect = 8e-05
Identities = 32/108 (29%), Positives = 56/108 (51%), Gaps = 5/108 (4%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGN-SPVMWAA 125
VR LL++G +VN E G + L LAC G+ + Q+L+ + E + G+ +P+M A+
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
+ G+ +++ L+ ++ + G TAL A A G V+ L
Sbjct: 281 SGGYLDIVKLLLLH----DADVNSQSATGNTALTYACAGGFVDIVKVL 324
Score = 45.4 bits (106), Expect = 8e-05
Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 14/107 (13%)
Query: 86 TALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGL 145
TAL+LAC GH + V +L+ E D G +P++ AA GH V+E L+ +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 146 RLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSD 192
+ +RT T L LA + G V L ARG+N +
Sbjct: 1117 QSERTKD---TPLSLACSGGRQEVVDLL-----------LARGANKE 1149
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 64.3 bits (155), Expect = 2e-10
Identities = 93/329 (28%), Positives = 125/329 (37%), Gaps = 33/329 (10%)
Query: 10 RAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRL 69
RAG RT L A A +L ++ +D R E G TPLM+A L L V
Sbjct: 1665 RAG-RTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDL----VEE 1719
Query: 70 LLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGH 129
L+ A V RD+ G+TAL A + A + L+Q D +A D+ +P+ AA G
Sbjct: 1720 LIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGA 1779
Query: 130 GAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGS 189
V + L+ LG + ++AGL +A R H + L G A A G
Sbjct: 1780 VEVAQLLL----GLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPGR 1835
Query: 190 NSDS-PPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKN-SGRHRAQG 247
+ P R + P H LPR + AG GG A + S A+G
Sbjct: 1836 EAGPFPRARTVSVSVPPH---GGGALPR--CRTLSAGAGPRGGGACLQARTWSVDLAARG 1890
Query: 248 SERPELGRSMS-LALGAVTEEEAARLRAGALMALPNSPQSSG-------------TGRWR 293
RS+S + G R AG PN G T W
Sbjct: 1891 GGAYSHCRSLSGVGAGGGPTPRGRRFSAGMRGPRPNPAIMRGRYGVAAGRGGRVSTDDWP 1950
Query: 294 SQEVLEGAPPTLAQAPIG---LSPHPEGG 319
V GA + + PI L+P PE G
Sbjct: 1951 CDWVALGACGSASNIPIPPPCLTPSPERG 1979
Score = 43.1 bits (100), Expect = 4e-04
Identities = 44/149 (29%), Positives = 65/149 (43%), Gaps = 13/149 (8%)
Query: 47 GRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF 106
G TPL +A P R LLE GA N D GRT L A + QLL++
Sbjct: 1634 GETPLHLAARFSRPTAARR----LLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRS 1689
Query: 107 SGDP-EAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARG 165
+A G +P+M AA ++E L+ + +G R ++ G TAL AAA
Sbjct: 1690 RQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGAR----DKWGKTALHWAAAVN 1745
Query: 166 HGTCVQALTGPWGRAAAAAAARGSNSDSP 194
+ ++L +A A A+ + +P
Sbjct: 1746 NARAARSLL----QAGADKDAQDNREQTP 1770
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 63.9 bits (154), Expect = 2e-10
Identities = 46/157 (29%), Positives = 77/157 (49%), Gaps = 14/157 (8%)
Query: 23 GKVHLARFVLDALDRSIIDCRAEQGRTPLMVAV--GLPDPALRARFVRLLLEQGAAVNLR 80
G L +L+A ++ +D + +G PL A G +P ++L+L+ G+AVN+
Sbjct: 60 GNTELISLLLEA--QAAVDIKDNKGMRPLHYAAWQGRKEP------MKLVLKAGSAVNIP 111
Query: 81 DERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSF 140
+ G L LA + GH D ++L+Q +P D++G +P+ A G V++ L+ S
Sbjct: 112 SDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSN 171
Query: 141 RRLGLRL----DRTNRAGLTALQLAAARGHGTCVQAL 173
L D T+ G + L LAA GH ++ L
Sbjct: 172 MCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLL 208
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 63.9 bits (154), Expect = 2e-10
Identities = 47/125 (37%), Positives = 64/125 (51%), Gaps = 11/125 (8%)
Query: 45 EQGRTPLMVAVGLPD-PALRARFVRLLLEQ-GAAVNLRDERGRTALSLACERGHLDAVQL 102
+ G P+ A D P+LR LL+E VN + + G T L LAC+ GHL+ Q
Sbjct: 136 DMGALPIHYAAAKGDFPSLR-----LLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQY 190
Query: 103 LVQFSG-DPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLA 161
LVQ G DP A G +P+ AA GH V+ +LV + L ++ G TA+ A
Sbjct: 191 LVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSC---TDVSLSEQDKDGATAMHFA 247
Query: 162 AARGH 166
A+RGH
Sbjct: 248 ASRGH 252
Score = 59.3 bits (142), Expect = 6e-09
Identities = 60/174 (34%), Positives = 75/174 (43%), Gaps = 14/174 (8%)
Query: 19 AMQAGKVHLARFVLD--ALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAA 76
A +AGK+H RF+++ AL + RA G TP A A ++ LL QG
Sbjct: 43 AARAGKLHCLRFLVEEAALPAA---ARARNGATPAHDASATGHLAC----LQWLLSQGGC 95
Query: 77 -VNLRDERGRTALSLACERGHLDAVQLLVQFSG-DPEAADSAGNSPVMWAAACGHGAVLE 134
V +D G T L LA GH + V L+ G DP AA G P+ +AAA G L
Sbjct: 96 RVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLR 155
Query: 135 FLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARG 188
LV + G+ N G T L LA GH Q L G A A G
Sbjct: 156 LLVEHYPE-GVNAQTKN--GATPLYLACQEGHLEVTQYLVQECGADPHARAHDG 206
Score = 47.8 bits (112), Expect = 2e-05
Identities = 40/131 (30%), Positives = 60/131 (45%), Gaps = 8/131 (6%)
Query: 43 RAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQL 102
RA G TPL A + + V L+ +++ +D+ G TA+ A RGH +
Sbjct: 202 RAHDGMTPLHAAAQMGHSPV---IVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSW 258
Query: 103 LVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAA 162
L+ G+ +AD G +P+ AA G + LV + G LD +R G TA L+
Sbjct: 259 LLLHGGE-ISADLWGGTPLHDAAENGELECCQILVVN----GAELDVRDRDGYTAADLSD 313
Query: 163 ARGHGTCVQAL 173
GH C + L
Sbjct: 314 FNGHSHCTRYL 324
Score = 42.0 bits (97), Expect = 0.001
Identities = 36/113 (31%), Positives = 52/113 (46%), Gaps = 4/113 (3%)
Query: 78 NLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSA-GNSPVMWAAACGHGAVLEFL 136
+LRD + A G L ++ LV+ + P AA + G +P A+A GH A L++L
Sbjct: 30 SLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWL 89
Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGS 189
+ G R+ + +G T L LAA GH V L G AA G+
Sbjct: 90 LSQG---GCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGA 139
Score = 29.6 bits (65), Expect = 4.7
Identities = 49/184 (26%), Positives = 65/184 (35%), Gaps = 39/184 (21%)
Query: 183 AAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNSGR 242
AA + S PP P P PE P P PL SAG G+
Sbjct: 586 AADPKASRELPPPPPPPPPPLPEAASSPPPAPPLPL---------------ESAGPGCGQ 630
Query: 243 HRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQS-------SGTGR--WR 293
R+ S +M G E A ++AG +L +PQS SG G+ ++
Sbjct: 631 RRSSSSTGSTKSFNMMSPTGD-NSELLAEIKAG--KSLKPTPQSKGLTTVFSGIGQPAFQ 687
Query: 294 SQEVLEGAPPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELE 353
L P L+ SP P P +G L S P P+ P G +L+
Sbjct: 688 PDSPLPSVSPALSPV---RSPTP---PAAGFQPLLNGSLVPVPPTT------PAPGVQLD 735
Query: 354 ANAL 357
AL
Sbjct: 736 VEAL 739
>gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain
containing 1 [Homo sapiens]
Length = 475
Score = 63.2 bits (152), Expect = 4e-10
Identities = 53/163 (32%), Positives = 80/163 (49%), Gaps = 16/163 (9%)
Query: 16 FLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGA 75
F +AM G V L + +LD+ +D + G TPLM A + + A VR+LL++GA
Sbjct: 50 FKKAMTIGDVSLVQELLDS--GISVDSNFQYGWTPLMYAASVAN----AELVRVLLDRGA 103
Query: 76 AVNLRDERGRTALSLAC-----ERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHG 130
+ ++ ++ L AC E L V+LL+ + DP A +P+M+AA GH
Sbjct: 104 NASFEKDK-QSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHT 162
Query: 131 AVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
V+ LV G ++ + G TAL AA +GH V L
Sbjct: 163 QVVALLVAH----GAEVNTQDENGYTALTWAARQGHKNIVLKL 201
Score = 38.5 bits (88), Expect = 0.010
Identities = 23/70 (32%), Positives = 32/70 (45%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
V LL+ GA VN +DE G TAL+ A +GH + V L++ + G P A
Sbjct: 165 VALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKR 224
Query: 127 CGHGAVLEFL 136
H + L
Sbjct: 225 NKHHEIFNLL 234
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 63.2 bits (152), Expect = 4e-10
Identities = 41/112 (36%), Positives = 61/112 (54%), Gaps = 6/112 (5%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQF--SGDPEAADSAGNSPVMWA 124
+ LL+ A ++RD+ G ++ A GH ++LL++ SG E+ A SP+ A
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLA 549
Query: 125 AACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGP 176
A GH LE L++S L +R ++ G TAL LAA +GH CV+AL P
Sbjct: 550 AYNGHHQALEVLLQSLVDLDIRDEK----GRTALDLAAFKGHTECVEALINP 597
Score = 62.4 bits (150), Expect = 7e-10
Identities = 51/173 (29%), Positives = 72/173 (41%), Gaps = 22/173 (12%)
Query: 33 DALDRSIIDCRAE------QGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRT 86
DA+ +ID A G TPL A AL + LL+ GA VN++ + G++
Sbjct: 227 DAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL---CLELLVNNGADVNIQSKDGKS 283
Query: 87 ALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLR 146
L + G Q L+Q G+ + D GN+P+ AA GH E L+ + R G
Sbjct: 284 PLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH----ELLINTLRTSGAD 339
Query: 147 LDRTNRAGLTALQLAAARGHGTCVQALTG---------PWGRAAAAAAARGSN 190
+ + L LAA H C + L +GR AAA G N
Sbjct: 340 TAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGN 392
Score = 62.4 bits (150), Expect = 7e-10
Identities = 40/103 (38%), Positives = 54/103 (52%), Gaps = 5/103 (4%)
Query: 28 ARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTA 87
A +L A+D SI+ CR ++GRTPL A A ++LLL A VN D G+TA
Sbjct: 795 ASLLLGAIDSSIVSCRDDKGRTPLRAAAF----ADHVECLQLLLRHSAPVNAVDNSGKTA 850
Query: 88 LSLACERGHLDAVQLLVQFS-GDPEAADSAGNSPVMWAAACGH 129
L +A E G AV +LV + D D N+P+ A + GH
Sbjct: 851 LMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893
Score = 60.8 bits (146), Expect = 2e-09
Identities = 39/107 (36%), Positives = 54/107 (50%), Gaps = 4/107 (3%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
V LLL +GA +N D++ R AL A GHLD V LL+ + D G +P+ AA+
Sbjct: 131 VNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAAS 190
Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
G V++ L+ LG+ +D N G TAL +A G V L
Sbjct: 191 NGQINVVKHLL----NLGVEIDEINVYGNTALHIACYNGQDAVVNEL 233
Score = 57.0 bits (136), Expect = 3e-08
Identities = 47/146 (32%), Positives = 70/146 (47%), Gaps = 6/146 (4%)
Query: 29 RFVLDALDR-SIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTA 87
R +L+ D +D + +G+TPLM+AV V LLLE+ A V+ D G TA
Sbjct: 626 RLLLEIADNPEAVDVKDAKGQTPLMLAVAYG----HIDAVSLLLEKEANVDTVDILGCTA 681
Query: 88 LSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRL 147
L GH + VQ+L++ DS G +P+ +AAA GH L L++
Sbjct: 682 LHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCC 741
Query: 148 DRTNRAGLTALQLAAARGHGTCVQAL 173
+ N+ G T L A G+ C++ L
Sbjct: 742 FKDNQ-GYTPLHWACYNGNENCIEVL 766
Score = 52.8 bits (125), Expect = 5e-07
Identities = 43/126 (34%), Positives = 58/126 (46%), Gaps = 8/126 (6%)
Query: 48 RTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFS 107
RTPL VA L D A + LL+ GA VN +D T L A +AVQ+L++ S
Sbjct: 17 RTPLHVAAFLGD----AEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72
Query: 108 GDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHG 167
D A D +P+ AAA E ++ + + ++R G TAL AA GH
Sbjct: 73 ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV----SDRGGRTALHHAALNGHV 128
Query: 168 TCVQAL 173
V L
Sbjct: 129 EMVNLL 134
Score = 52.4 bits (124), Expect = 7e-07
Identities = 31/93 (33%), Positives = 50/93 (53%), Gaps = 3/93 (3%)
Query: 77 VNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFL 136
V+ RD++GRT L A H++ +QLL++ S A D++G + +M AA G ++ L
Sbjct: 807 VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL 866
Query: 137 VRSFRRLGLRLDRTNRAGLTALQLAAARGHGTC 169
V S + L ++ T L LA ++GH C
Sbjct: 867 VNSAQ---ADLTVKDKDLNTPLHLACSKGHEKC 896
Score = 52.0 bits (123), Expect = 9e-07
Identities = 40/144 (27%), Positives = 61/144 (42%), Gaps = 41/144 (28%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQ------------------------- 101
+ +LL+ +++RDE+GRTAL LA +GH + V+
Sbjct: 558 LEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASV 617
Query: 102 ---------LLVQFSGDPEAA---DSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDR 149
LL++ + +PEA D+ G +P+M A A GH + L+ +D
Sbjct: 618 INGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEK----EANVDT 673
Query: 150 TNRAGLTALQLAAARGHGTCVQAL 173
+ G TAL GH CVQ L
Sbjct: 674 VDILGCTALHRGIMTGHEECVQML 697
Score = 51.6 bits (122), Expect = 1e-06
Identities = 40/134 (29%), Positives = 60/134 (44%), Gaps = 8/134 (5%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
++ R + +TPL VA + LL ++VN+ D GRTAL A GH++
Sbjct: 75 VNARDKNWQTPLHVAAANKAVKCAEVIIPLL----SSVNVSDRGGRTALHHAALNGHVEM 130
Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQ 159
V LL+ + A D + WAA GH V+ L+ G + ++ G T L
Sbjct: 131 VNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH----GAEVTCKDKKGYTPLH 186
Query: 160 LAAARGHGTCVQAL 173
AA+ G V+ L
Sbjct: 187 AAASNGQINVVKHL 200
Score = 50.8 bits (120), Expect = 2e-06
Identities = 39/135 (28%), Positives = 65/135 (48%), Gaps = 9/135 (6%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
+ C+ ++G TPL A + V+ LL G ++ + G TAL +AC G
Sbjct: 174 VTCKDKKGYTPLHAAASNG----QINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAV 229
Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAV-LEFLVRSFRRLGLRLDRTNRAGLTAL 158
V L+ + + ++ G +P+ +AAA HGA+ LE LV + G ++ ++ G + L
Sbjct: 230 VNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNN----GADVNIQSKDGKSPL 285
Query: 159 QLAAARGHGTCVQAL 173
+ A G T Q L
Sbjct: 286 HMTAVHGRFTRSQTL 300
Score = 45.1 bits (105), Expect = 1e-04
Identities = 44/156 (28%), Positives = 60/156 (38%), Gaps = 17/156 (10%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
IDC + G TPL VA L + L GA L LA H D
Sbjct: 307 IDCVDKDGNTPLHVAARYGHELL----INTLRTSGADTAKCGIHSMFPLHLAALNAHSDC 362
Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQ 159
+ L+ + + D G + + AAA G+ ++ L S G + ++ G T L
Sbjct: 363 CRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSS----GADFHKKDKCGRTPLH 418
Query: 160 LAAARGHGTCVQAL---------TGPWGRAAAAAAA 186
AAA H C++ L T WGR A AA
Sbjct: 419 YAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
Score = 38.1 bits (87), Expect = 0.013
Identities = 31/109 (28%), Positives = 51/109 (46%), Gaps = 5/109 (4%)
Query: 67 VRLLLEQGAAVNLRDERGRTA--LSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWA 124
+ LLLE+ + + G T L LA GH A+++L+Q D + D G + + A
Sbjct: 523 LELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLA 582
Query: 125 AACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
A GH +E L+ + ++ + T R T L + GH C++ L
Sbjct: 583 AFKGHTECVEALINPGASIFVKDNVTKR---TPLHASVINGHTLCLRLL 628
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 63.2 bits (152), Expect = 4e-10
Identities = 51/144 (35%), Positives = 70/144 (48%), Gaps = 6/144 (4%)
Query: 31 VLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSL 90
+L AL I++ R +GRTPL A A +R+LL+ A VN D GRTAL
Sbjct: 842 LLGALGAKIVNSRDAKGRTPLHAAAF----ADNVSGLRMLLQHQAEVNATDHTGRTALMT 897
Query: 91 ACERGHLDAVQ-LLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDR 149
A E G AV+ LL + D D N+ + A + GH ++ + LGL ++
Sbjct: 898 AAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGL-INA 956
Query: 150 TNRAGLTALQLAAARGHGTCVQAL 173
TN A L +AA G + VQAL
Sbjct: 957 TNSALQMPLHIAARNGLASVVQAL 980
Score = 62.4 bits (150), Expect = 7e-10
Identities = 48/158 (30%), Positives = 75/158 (47%), Gaps = 9/158 (5%)
Query: 19 AMQAGKVHLARFVLDALDRS-IIDCRAEQGRTPLMVAV--GLPDPALRARFVRLLLEQGA 75
A +G ++D+ +R+ I D G+TPLM+A+ G D V LLLE+G+
Sbjct: 659 AAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVD------CVHLLLEKGS 712
Query: 76 AVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEF 135
+ D RGRTAL G D + L+ D G +P+ A+ACGH AVL
Sbjct: 713 TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772
Query: 136 LVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
L+++ + +G + + A+ GH C++ L
Sbjct: 773 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810
Score = 55.5 bits (132), Expect = 8e-08
Identities = 36/99 (36%), Positives = 53/99 (53%), Gaps = 4/99 (4%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
V LLL +GA++N+ D++ R L A GHL+ ++LLV D D G + AAA
Sbjct: 156 VNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAA 215
Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARG 165
G V+++L+ R+G +D N G TAL +A G
Sbjct: 216 SGQIEVVKYLL----RMGAEIDEPNAFGNTALHIACYLG 250
Score = 55.1 bits (131), Expect = 1e-07
Identities = 43/134 (32%), Positives = 59/134 (44%), Gaps = 8/134 (5%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
++ R + +TPL VA LL +++N+ D GR+AL A GHL+
Sbjct: 100 VNARDKLWQTPLHVAAANRATKCAEALAPLL----SSLNVADRSGRSALHHAVHSGHLET 155
Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQ 159
V LL+ D P+ WAA GH VL+ LV LG + +R G L
Sbjct: 156 VNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCK----DRKGYGLLH 211
Query: 160 LAAARGHGTCVQAL 173
AAA G V+ L
Sbjct: 212 TAAASGQIEVVKYL 225
Score = 55.1 bits (131), Expect = 1e-07
Identities = 40/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 45 EQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLV 104
++G TPL VA + AL + LL+ GA VN + + G++ L +A G Q+L+
Sbjct: 270 DKGFTPLHVAAVSTNGAL---CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326
Query: 105 QFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAAR 164
Q + + AD GN+P+ AA GH E L+ + G R + L LA
Sbjct: 327 QNGSEIDCADKFGNTPLHVAARYGH----ELLISTLMTNGADTARRGIHDMFPLHLAVLF 382
Query: 165 GHGTCVQAL 173
G C + L
Sbjct: 383 GFSDCCRKL 391
Score = 54.3 bits (129), Expect = 2e-07
Identities = 43/123 (34%), Positives = 58/123 (47%), Gaps = 3/123 (2%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGN-SPVMWAA 125
++ L E +++RD +GRTAL LA ERG + V++L + +P+ AA
Sbjct: 601 LKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAA 660
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAA 185
A GH L L+ S R + D + G T L LA GH CV L G A AA
Sbjct: 661 ASGHTDSLHLLIDSGERADI-TDVMDAYGQTPLMLAIMNGHVDCVHLLLEK-GSTADAAD 718
Query: 186 ARG 188
RG
Sbjct: 719 LRG 721
Score = 45.8 bits (107), Expect = 6e-05
Identities = 44/138 (31%), Positives = 61/138 (44%), Gaps = 14/138 (10%)
Query: 6 DLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLM--VAVGLPDPALR 63
D+ G + A+ G V +L+ S D +GRT L G D
Sbjct: 682 DVMDAYGQTPLMLAIMNGHVDCVHLLLEK--GSTADAADLRGRTALHRGAVTGCED---- 735
Query: 64 ARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQ--FSGDPEAA--DSAGNS 119
+ LL+ A V RD +GRT + LA GH ++ L+Q S DP A D +G S
Sbjct: 736 --CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYS 793
Query: 120 PVMWAAACGHGAVLEFLV 137
P+ WA+ GH LE L+
Sbjct: 794 PMHWASYTGHEDCLELLL 811
Score = 41.2 bits (95), Expect = 0.002
Identities = 33/107 (30%), Positives = 50/107 (46%), Gaps = 4/107 (3%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
VR LL Q +N+ D+ RT L A G + +QLL+ + A D+ +P+ AAA
Sbjct: 24 VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAA 83
Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
+ VL L+ + R ++ T L +AAA C +AL
Sbjct: 84 SRNEKVLGLLLAHSADVNAR----DKLWQTPLHVAAANRATKCAEAL 126
Score = 40.8 bits (94), Expect = 0.002
Identities = 36/109 (33%), Positives = 55/109 (50%), Gaps = 7/109 (6%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQL-LVQFSGDPEAADSAGNSPVMWAA 125
V+ LL GA ++ + G TAL +AC G DAV + LV + + G +P+ AA
Sbjct: 222 VKYLLRMGAEIDEPNAFGNTALHIACYLGQ-DAVAIELVNAGANVNQPNDKGFTPLHVAA 280
Query: 126 ACGHGAV-LEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
+GA+ LE LV + G ++ ++ G + L +AA G T Q L
Sbjct: 281 VSTNGALCLELLVNN----GADVNYQSKEGKSPLHMAAIHGRFTRSQIL 325
Score = 37.7 bits (86), Expect = 0.017
Identities = 23/60 (38%), Positives = 28/60 (46%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
+ LLL GA + RD+ GRT L A G LV AD G SP+ +AAA
Sbjct: 439 LNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAA 498
Score = 33.9 bits (76), Expect = 0.25
Identities = 52/192 (27%), Positives = 69/192 (35%), Gaps = 32/192 (16%)
Query: 38 SIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLA------ 91
S IDC + G TPL VA L + L+ GA R L LA
Sbjct: 330 SEIDCADKFGNTPLHVAARYGHELL----ISTLMTNGADTARRGIHDMFPLHLAVLFGFS 385
Query: 92 -CERGHLDAVQL-----------LVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRS 139
C R L + QL ++ D D+ G + + AA+ G+ L L+ S
Sbjct: 386 DCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS 445
Query: 140 FRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSDSPPGRPA 199
G L R ++ G T L AAA G C L A A ++
Sbjct: 446 ----GADLRRRDKFGRTPLHYAAANGSYQCAVTL------VTAGAGVNEADCKGCSPLHY 495
Query: 200 PAASPEHRRPSP 211
AAS +RR P
Sbjct: 496 AAASDTYRRAEP 507
Score = 30.8 bits (68), Expect = 2.1
Identities = 30/106 (28%), Positives = 40/106 (37%), Gaps = 31/106 (29%)
Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVR-SFRRLG-------------- 144
++ L+ DP D G + V +AAA G+ LE L+ SF L
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
Query: 145 ----------------LRLDRTNRAGLTALQLAAARGHGTCVQALT 174
+ LD + G TAL LA RG CV+ LT
Sbjct: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLT 638
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 62.8 bits (151), Expect = 5e-10
Identities = 36/107 (33%), Positives = 57/107 (53%), Gaps = 4/107 (3%)
Query: 67 VRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAA 126
V LL+ G + RD G TAL AC +G D V+LL+ +P P++WAA
Sbjct: 87 VEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAG 146
Query: 127 CGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
GH ++ L+++ G +++ +++ G T L AA +GH CV+ L
Sbjct: 147 RGHADIVHLLLQN----GAKVNCSDKYGTTPLVWAARKGHLECVKHL 189
Score = 54.3 bits (129), Expect = 2e-07
Identities = 43/134 (32%), Positives = 62/134 (46%), Gaps = 8/134 (5%)
Query: 40 IDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDA 99
+D R E G+TPLM+A + V+ L++ GA NL D TAL A + GH+
Sbjct: 31 VDERNECGQTPLMIAAEQGN----LEIVKELIKNGANCNLEDLDNWTALISASKEGHVHI 86
Query: 100 VQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQ 159
V+ L++ + E D G + +MWA G V+E L+ G T + +
Sbjct: 87 VEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSH----GANPSVTGLYSVYPII 142
Query: 160 LAAARGHGTCVQAL 173
AA RGH V L
Sbjct: 143 WAAGRGHADIVHLL 156
Score = 51.6 bits (122), Expect = 1e-06
Identities = 37/111 (33%), Positives = 57/111 (51%), Gaps = 6/111 (5%)
Query: 64 ARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMW 123
A V LLL+ GA VN D+ G T L A +GHL+ V+ L+ D + + + ++
Sbjct: 150 ADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIV 209
Query: 124 AAACGH-GAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
A G+ +V E L R+ ++ T++ G TAL +A+ GH VQ L
Sbjct: 210 AVKGGYTQSVKEILKRN-----PNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Score = 49.7 bits (117), Expect = 4e-06
Identities = 41/160 (25%), Positives = 75/160 (46%), Gaps = 10/160 (6%)
Query: 12 GTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLL 71
GT + A + G + + +L + +D T L+VAV + V+ +L
Sbjct: 170 GTTPLVWAARKGHLECVKHLLAM--GADVDQEGANSMTALIVAV----KGGYTQSVKEIL 223
Query: 72 EQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGA 131
++ VNL D+ G TAL +A + GH + VQ L+ D +G++ ++ A GH
Sbjct: 224 KRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVE 283
Query: 132 VLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQ 171
++ L++ + + +R + TAL A +G+ T V+
Sbjct: 284 IVRALLQKYADIDIR----GQDNKTALYWAVEKGNATMVR 319
Score = 46.6 bits (109), Expect = 4e-05
Identities = 35/114 (30%), Positives = 61/114 (53%), Gaps = 9/114 (7%)
Query: 60 PALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNS 119
PAL+A LLE+ V+ R+E G+T L +A E+G+L+ V+ L++ + D +
Sbjct: 19 PALKA-----LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
Query: 120 PVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQAL 173
++ A+ GH ++E L+ + G+ L+ + G TAL A +G V+ L
Sbjct: 74 ALISASKEGHVHIVEELL----KCGVNLEHRDMGGWTALMWACYKGRTDVVELL 123
Score = 45.8 bits (107), Expect = 6e-05
Identities = 39/156 (25%), Positives = 74/156 (47%), Gaps = 10/156 (6%)
Query: 6 DLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRAR 65
+L + G + A + G + + +LDA + ++ G T L+ AV
Sbjct: 230 NLTDKDGNTALMIASKEGHTEIVQDLLDA--GTYVNIPDRSGDTVLIGAVR----GGHVE 283
Query: 66 FVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
VR LL++ A +++R + +TAL A E+G+ V+ ++Q + D E G +P++ A
Sbjct: 284 IVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKAT 343
Query: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLA 161
+ V+E L+ G ++ ++ G T L +A
Sbjct: 344 KMRNIEVVELLLDK----GAKVSAVDKKGDTPLHIA 375
Score = 31.6 bits (70), Expect = 1.2
Identities = 28/102 (27%), Positives = 45/102 (44%), Gaps = 15/102 (14%)
Query: 37 RSIIDCRAE------QGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSL 90
R I+ C + G TPL+ A + + V LLL++GA V+ D++G T L +
Sbjct: 319 RDILQCNPDTEICTKDGETPLIKATKMRN----IEVVELLLDKGAKVSAVDKKGDTPLHI 374
Query: 91 ACERGHLDAVQLLVQFSGDPE---AADSAGNSPVMWAAACGH 129
A +LL++ D + AG +P + C H
Sbjct: 375 AIRGRSRKLAELLLRNPKDGRLLYRPNKAGETP--YNIDCSH 414
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,533,470
Number of Sequences: 37866
Number of extensions: 1055468
Number of successful extensions: 11403
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 381
Number of HSP's successfully gapped in prelim test: 733
Number of HSP's that attempted gapping in prelim test: 8030
Number of HSP's gapped (non-prelim): 3332
length of query: 380
length of database: 18,247,518
effective HSP length: 104
effective length of query: 276
effective length of database: 14,309,454
effective search space: 3949409304
effective search space used: 3949409304
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.