Guide to the Human Genome
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Search of human proteins with 169171173

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169171173 PREDICTED: similar to hCG2036731 [Homo sapiens]
         (503 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169171173 PREDICTED: similar to hCG2036731 [Homo sapiens]         1017   0.0  
gi|169171663 PREDICTED: similar to hCG2036731 [Homo sapiens]         1017   0.0  
gi|239508938 PREDICTED: similar to hCG2036731 [Homo sapiens]         1017   0.0  
gi|239749177 PREDICTED: similar to hCG2036731 [Homo sapiens]          983   0.0  
gi|203097724 cadherin-like 29 [Homo sapiens]                           91   2e-18
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]             86   6e-17
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]          84   2e-16
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]         84   2e-16
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s...    83   5e-16
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]           82   9e-16
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]            80   6e-15
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]       78   2e-14
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo...    78   2e-14
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ...    78   2e-14
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]             73   5e-13
gi|157426847 protocadherin 19 isoform a [Homo sapiens]                 72   9e-13
gi|157426845 protocadherin 19 isoform b [Homo sapiens]                 72   9e-13
gi|40255133 hypothetical protein LOC222256 [Homo sapiens]              72   9e-13
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]            72   9e-13
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]            72   9e-13
gi|47059046 dachsous 2 isoform 1 [Homo sapiens]                        72   1e-12
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]         72   2e-12
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]         72   2e-12
gi|116534898 desmoglein 2 preproprotein [Homo sapiens]                 70   3e-12
gi|16507964 cadherin-like 23 isoform 2 precursor [Homo sapiens]        70   3e-12
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]           70   4e-12
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]         70   6e-12
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]         70   6e-12
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]         70   6e-12
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s...    69   1e-11

>gi|169171173 PREDICTED: similar to hCG2036731 [Homo sapiens]
          Length = 503

 Score = 1017 bits (2630), Expect = 0.0
 Identities = 503/503 (100%), Positives = 503/503 (100%)

Query: 1   MSMGSKLKCEHDTNGKVEPHAADNHFQGAGLGPNQIMAGSGVITATKIFNYETDPIRFLL 60
           MSMGSKLKCEHDTNGKVEPHAADNHFQGAGLGPNQIMAGSGVITATKIFNYETDPIRFLL
Sbjct: 1   MSMGSKLKCEHDTNGKVEPHAADNHFQGAGLGPNQIMAGSGVITATKIFNYETDPIRFLL 60

Query: 61  IVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVF 120
           IVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVF
Sbjct: 61  IVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVF 120

Query: 121 ANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFC 180
           ANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFC
Sbjct: 121 ANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFC 180

Query: 181 LDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF 240
           LDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF
Sbjct: 181 LDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF 240

Query: 241 STGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYT 300
           STGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYT
Sbjct: 241 STGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYT 300

Query: 301 IVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTA 360
           IVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTA
Sbjct: 301 IVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTA 360

Query: 361 QVTISVLNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQDESRK 420
           QVTISVLNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQDESRK
Sbjct: 361 QVTISVLNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQDESRK 420

Query: 421 KRLEKMSLSSYYFKKCFTDVIRADNHNNDYFPSVTNITRANQVSRPKGLDWYQGKSRVDA 480
           KRLEKMSLSSYYFKKCFTDVIRADNHNNDYFPSVTNITRANQVSRPKGLDWYQGKSRVDA
Sbjct: 421 KRLEKMSLSSYYFKKCFTDVIRADNHNNDYFPSVTNITRANQVSRPKGLDWYQGKSRVDA 480

Query: 481 LKKEILGNTSVTPGNNKAHTVKP 503
           LKKEILGNTSVTPGNNKAHTVKP
Sbjct: 481 LKKEILGNTSVTPGNNKAHTVKP 503


>gi|169171663 PREDICTED: similar to hCG2036731 [Homo sapiens]
          Length = 503

 Score = 1017 bits (2629), Expect = 0.0
 Identities = 502/503 (99%), Positives = 503/503 (100%)

Query: 1   MSMGSKLKCEHDTNGKVEPHAADNHFQGAGLGPNQIMAGSGVITATKIFNYETDPIRFLL 60
           MSMGSKLKCEHDTNGKVEPHAADNHFQGAGLGPNQIMAGSGVITATKIFNYETDPIRFLL
Sbjct: 1   MSMGSKLKCEHDTNGKVEPHAADNHFQGAGLGPNQIMAGSGVITATKIFNYETDPIRFLL 60

Query: 61  IVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVF 120
           IVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVF
Sbjct: 61  IVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVF 120

Query: 121 ANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFC 180
           ANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFC
Sbjct: 121 ANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFC 180

Query: 181 LDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF 240
           LDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF
Sbjct: 181 LDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF 240

Query: 241 STGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYT 300
           STGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYT
Sbjct: 241 STGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYT 300

Query: 301 IVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTA 360
           +VGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTA
Sbjct: 301 VVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTA 360

Query: 361 QVTISVLNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQDESRK 420
           QVTISVLNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQDESRK
Sbjct: 361 QVTISVLNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQDESRK 420

Query: 421 KRLEKMSLSSYYFKKCFTDVIRADNHNNDYFPSVTNITRANQVSRPKGLDWYQGKSRVDA 480
           KRLEKMSLSSYYFKKCFTDVIRADNHNNDYFPSVTNITRANQVSRPKGLDWYQGKSRVDA
Sbjct: 421 KRLEKMSLSSYYFKKCFTDVIRADNHNNDYFPSVTNITRANQVSRPKGLDWYQGKSRVDA 480

Query: 481 LKKEILGNTSVTPGNNKAHTVKP 503
           LKKEILGNTSVTPGNNKAHTVKP
Sbjct: 481 LKKEILGNTSVTPGNNKAHTVKP 503


>gi|239508938 PREDICTED: similar to hCG2036731 [Homo sapiens]
          Length = 503

 Score = 1017 bits (2629), Expect = 0.0
 Identities = 502/503 (99%), Positives = 503/503 (100%)

Query: 1   MSMGSKLKCEHDTNGKVEPHAADNHFQGAGLGPNQIMAGSGVITATKIFNYETDPIRFLL 60
           MSMGSKLKCEHDTNGKVEPHAADNHFQGAGLGPNQIMAGSGVITATKIFNYETDPIRFLL
Sbjct: 1   MSMGSKLKCEHDTNGKVEPHAADNHFQGAGLGPNQIMAGSGVITATKIFNYETDPIRFLL 60

Query: 61  IVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVF 120
           IVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVF
Sbjct: 61  IVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVF 120

Query: 121 ANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFC 180
           ANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFC
Sbjct: 121 ANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFC 180

Query: 181 LDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF 240
           LDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF
Sbjct: 181 LDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF 240

Query: 241 STGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYT 300
           STGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYT
Sbjct: 241 STGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYT 300

Query: 301 IVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTA 360
           +VGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTA
Sbjct: 301 VVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTA 360

Query: 361 QVTISVLNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQDESRK 420
           QVTISVLNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQDESRK
Sbjct: 361 QVTISVLNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQDESRK 420

Query: 421 KRLEKMSLSSYYFKKCFTDVIRADNHNNDYFPSVTNITRANQVSRPKGLDWYQGKSRVDA 480
           KRLEKMSLSSYYFKKCFTDVIRADNHNNDYFPSVTNITRANQVSRPKGLDWYQGKSRVDA
Sbjct: 421 KRLEKMSLSSYYFKKCFTDVIRADNHNNDYFPSVTNITRANQVSRPKGLDWYQGKSRVDA 480

Query: 481 LKKEILGNTSVTPGNNKAHTVKP 503
           LKKEILGNTSVTPGNNKAHTVKP
Sbjct: 481 LKKEILGNTSVTPGNNKAHTVKP 503


>gi|239749177 PREDICTED: similar to hCG2036731 [Homo sapiens]
          Length = 564

 Score =  983 bits (2542), Expect = 0.0
 Identities = 486/487 (99%), Positives = 487/487 (100%)

Query: 1   MSMGSKLKCEHDTNGKVEPHAADNHFQGAGLGPNQIMAGSGVITATKIFNYETDPIRFLL 60
           MSMGSKLKCEHDTNGKVEPHAADNHFQGAGLGPNQIMAGSGVITATKIFNYETDPIRFLL
Sbjct: 1   MSMGSKLKCEHDTNGKVEPHAADNHFQGAGLGPNQIMAGSGVITATKIFNYETDPIRFLL 60

Query: 61  IVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVF 120
           IVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVF
Sbjct: 61  IVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVF 120

Query: 121 ANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFC 180
           ANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFC
Sbjct: 121 ANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFC 180

Query: 181 LDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF 240
           LDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF
Sbjct: 181 LDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF 240

Query: 241 STGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYT 300
           STGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYT
Sbjct: 241 STGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYT 300

Query: 301 IVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTA 360
           +VGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTA
Sbjct: 301 VVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTA 360

Query: 361 QVTISVLNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQDESRK 420
           QVTISVLNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQDESRK
Sbjct: 361 QVTISVLNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQDESRK 420

Query: 421 KRLEKMSLSSYYFKKCFTDVIRADNHNNDYFPSVTNITRANQVSRPKGLDWYQGKSRVDA 480
           KRLEKMSLSSYYFKKCFTDVIRADNHNNDYFPSVTNITRANQVSRPKGLDWYQGKSRVDA
Sbjct: 421 KRLEKMSLSSYYFKKCFTDVIRADNHNNDYFPSVTNITRANQVSRPKGLDWYQGKSRVDA 480

Query: 481 LKKEILG 487
           LKKEILG
Sbjct: 481 LKKEILG 487


>gi|203097724 cadherin-like 29 [Homo sapiens]
          Length = 788

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 62/177 (35%), Positives = 91/177 (51%), Gaps = 12/177 (6%)

Query: 247 ITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNL 306
           + V+V V+ INE +P  + +  TF V E++   TL+G V  TD D+P +N+EY   GG  
Sbjct: 429 VPVLVMVTPINEFSP--ACAPRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGG-- 484

Query: 307 GTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISV 366
             P  F ++  +G + LL  L+ E +  Y++ V V D   D  P+     SG+  +TI V
Sbjct: 485 --PTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPN--HHLSGSCTITIEV 540

Query: 367 LNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEH----LSYSIVGEQDESR 419
            ++ND  P C PP  E  IY+ +         S   PQE      SYSIVG   ++R
Sbjct: 541 EDVNDHAPECEPPFQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNR 597


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 95/341 (27%), Positives = 157/341 (46%), Gaps = 56/341 (16%)

Query: 88   DPKFSSGTATLEIDEDYPLFQSIYRVTATDEVFANGDRLNVG----GDHCAR-PFPLDSI 142
            DP+     AT  +D +     S+  V A D + ++  R+N+      DH  +   P+ S 
Sbjct: 1790 DPESGDLIATRRLDRERRSKYSLL-VRADDGLQSSDMRINITVSDVNDHTPKFSRPVYSF 1848

Query: 143  NVTEKKSVGEIIARVKATDRDE----DSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDN 198
            ++ E    G ++A + ATD D     + + I +   +  +F L+P TG   L + L+ + 
Sbjct: 1849 DIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEV 1908

Query: 199  PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
                + Y L   A D G                        F+T    I V   +  +N+
Sbjct: 1909 ---QQYYILTVRAEDGGGQ----------------------FTT----IRVYFNILDVND 1939

Query: 259  LNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN-MEYTIVGG-NLGTPPKFYIEP 316
              PI S ++++ S+ EN PV + V     TDAD   N+ + Y+I  G +LG   +F ++ 
Sbjct: 1940 NPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLG---QFTVDK 1996

Query: 317  DTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVC 376
            + GV+K+L +L+RE +S Y + V+V DL       P  + + TAQV+I +L++ND PP  
Sbjct: 1997 N-GVLKVLKALDRESQSFYNLVVQVHDLPQ----IPASRFTSTAQVSIILLDVNDNPPTF 2051

Query: 377  NPPHL----ETQIYSTVESFHSAQLFSKDS-PQEHLSYSIV 412
              P L    E     TV     AQ    DS P  ++ Y+++
Sbjct: 2052 LSPKLTYIPENTPIDTV--VFKAQATDPDSGPNSYIEYTLL 2090



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 72/245 (29%), Positives = 117/245 (47%), Gaps = 46/245 (18%)

Query: 139  LDSINVTEKKSVGEIIARVKATDRDE--DSSIIYSFKTQQK-MFCLDPFTGTITLLQPLN 195
            ++S+NV E    G  I + KA D DE  +  ++YS K   K +F ++   GTI+LL PL+
Sbjct: 897  IESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLD 956

Query: 196  LDNPSNSKIYSLETEATDNG--NNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRV 253
            +   S    Y +E  A+D G    +SS   TV+V +V                       
Sbjct: 957  VHAGS----YQIEILASDMGVPQLSSSVILTVYVHDV----------------------- 989

Query: 254  SRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKF 312
               N+ +P+    ++  ++ E+ PV++   KV  +D D   N  + YTI  GN G    F
Sbjct: 990  ---NDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTG--DAF 1044

Query: 313  YIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDE 372
             I PD G + +   L+RE++ +Y + V    + +D   +PL   S T  VT+ + ++ND 
Sbjct: 1045 GIFPD-GQLYIKSELDRELQDRYVLMV----VASDRAVEPL---SATVNVTVILEDVNDN 1096

Query: 373  PPVCN 377
             P+ N
Sbjct: 1097 RPLFN 1101



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 80/310 (25%), Positives = 129/310 (41%), Gaps = 49/310 (15%)

Query: 134  ARPFPLDSINVTEKKSVGEI--IARVKATDRDEDSSIIYSFK----TQQKMFCLDPFTGT 187
            A  F  D    T  +S   +  + RV A+D DE ++ +  +      +++ F +D  +G 
Sbjct: 1207 APKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQ 1266

Query: 188  ITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAII 247
            +TL+  L+ +    +  YSL  +A D+G    + T T+ ++ +D+               
Sbjct: 1267 VTLIGKLDYEA---TPAYSLVIQAVDSGTIPLNSTCTLNIDILDE--------------- 1308

Query: 248  TVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVG-GN 305
                     N+  P    S     V EN  +  LV  VT TD+D   N ++ Y+I G  N
Sbjct: 1309 ---------NDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNN 1359

Query: 306  LGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTIS 365
             GT   F I P+TG I L   L+ E +S YK+   +T  D    P     RS T  V I 
Sbjct: 1360 HGT---FSISPNTGSIFLAKKLDFETQSLYKL--NITAKDQGRPP-----RSSTMSVVIH 1409

Query: 366  VLNMNDEPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQE----HLSYSIVGEQDESRKK 421
            V + ND PP   P  +   I   +    S    +   P       LSY+I+ +       
Sbjct: 1410 VRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHF 1469

Query: 422  RLEKMSLSSY 431
             ++++  + Y
Sbjct: 1470 TIDEVKGTIY 1479



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 66/239 (27%), Positives = 103/239 (43%), Gaps = 37/239 (15%)

Query: 142  INVTEKKSVGEIIARVKATDRD--EDSSIIYSFK--TQQKMFCLDPFTGTITLLQPLNLD 197
            ++V E   +GE+++ V ATD D  +++ + YS         F + P TG+I L + L+ +
Sbjct: 1322 VDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFE 1381

Query: 198  NPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRIN 257
              S   +Y L   A D G    S T +V + +V D     PSF  G    +++       
Sbjct: 1382 TQS---LYKLNITAKDQGRPPRSSTMSVVI-HVRDFNDNPPSFPPGDIFKSIV------- 1430

Query: 258  ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN-MEYTIVGGNLGTPPKFYIEP 316
                            EN P+ T V  VT  D D   N  + YTI+   +     F I+ 
Sbjct: 1431 ----------------ENIPIGTSVISVTAHDPDADINGQLSYTIIQ-QMPRGNHFTIDE 1473

Query: 317  DTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
              G I     ++RE  + +++ VK  D    A+P   R R     VTI V ++ND  P+
Sbjct: 1474 VKGTIYTNAEIDREFANLFELTVKAND---QAVPIETR-RYALKNVTILVTDLNDNVPM 1528



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 61/240 (25%), Positives = 108/240 (45%), Gaps = 43/240 (17%)

Query: 142 INVTEKKSVGEIIARVKATDRD--EDSSIIYSFK---TQQKMFCLDPFTGTITLLQPLNL 196
           ++V E    G  +  ++ATD D  ++ ++ +S +   T ++ F LDP +G ++ +  L+ 
Sbjct: 590 VSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDR 649

Query: 197 DNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRI 256
           +  +    YSL   ATD G+   S    + V  +D                        I
Sbjct: 650 EEQA---FYSLLVLATDLGSPPQSSMARINVSLLD------------------------I 682

Query: 257 NELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN-MEYTIVGGNLGTPPKFYIE 315
           N+ +P+     +   + EN P  + +  V+ TD D   N  ++Y+I  G+     +F + 
Sbjct: 683 NDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDRS---RFQVN 739

Query: 316 PDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
             +GVI    +L+RE ++ Y++ +  TD  N        Q    A VTI+VL+  D PPV
Sbjct: 740 AQSGVISTRMALDREEKTAYQLQIVATDGGN-------LQSPNQAIVTITVLDTQDNPPV 792



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 88/383 (22%), Positives = 155/383 (40%), Gaps = 66/383 (17%)

Query: 40   SGVITATKIFNYETDPIRFLLI--VDTGRLYRHV-LTINIIDVPESPNCTADPKFSSGTA 96
            +GV   T++ +YE      L +   D G  +  + +  NI+DV ++P     P FS  + 
Sbjct: 1895 TGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNP-----PIFSLNSY 1949

Query: 97   TLEIDEDYPLFQSI--YRVTATDEVFANGDRLNVGGDHCARPFPLDSINVT--------E 146
            +  + E+ P+  ++  + VT  D+   +    ++        F +D   V         E
Sbjct: 1950 STSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKNGVLKVLKALDRE 2009

Query: 147  KKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNSKIYS 206
             +S   ++ +V   D  +  +  ++   Q  +  LD      T L P     P N+ I +
Sbjct: 2010 SQSFYNLVVQVH--DLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTPIDT 2067

Query: 207  L--ETEATDNGNNTSSYTFTVFVENVDDPISC---------------------------- 236
            +  + +ATD  +  +SY     +  + +  S                             
Sbjct: 2068 VVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVAT 2127

Query: 237  ---DPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWP 293
                PS S+      V+V V  IN+ NPI + + +   + EN+   T + +V   D D  
Sbjct: 2128 DKGQPSLSSSTE---VVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEG 2184

Query: 294  FNN-MEYTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDP 352
             N  + Y IV GN  T  +F I+  TG I +   L+RE    Y + V+ TD  +      
Sbjct: 2185 TNGQVRYGIVNGN--TNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGS------ 2236

Query: 353  LRQRSGTAQVTISVLNMNDEPPV 375
               R+ T+ V+I +L++ND  PV
Sbjct: 2237 -TPRTDTSTVSIVLLDINDFVPV 2258



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 105/398 (26%), Positives = 166/398 (41%), Gaps = 87/398 (21%)

Query: 89   PKFSSGTAT----LEIDEDYPLF-QSIYRV-------TATD--EVFA-NGD-------RL 126
            P  SS T      L+I+++ P+F Q++Y+V       T TD  +VFA +GD       R 
Sbjct: 2132 PSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRY 2191

Query: 127  NVGGDHCARPFPLDSINVT-------EKKSVGEIIARVKATDRDED--------SSIIYS 171
             +   +  + F +DS+          +++        V+ATDR           S ++  
Sbjct: 2192 GIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLD 2251

Query: 172  FKTQQKMFCLDPFT-------GTI--TLLQPLNLDNP--SNSKIYSLETEATDNGNNTSS 220
                  +F L P++       GT+  T+LQ +  D+   SNSK+    +     GN  ++
Sbjct: 2252 INDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKL----SYVLFGGNEDNA 2307

Query: 221  YTFTV-----------------FVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIG 263
            +T +                  FV  +    S  P+  TG   I VIV    +N+  P  
Sbjct: 2308 FTLSASGELGVTQSLDRETKERFVLMITATDSGSPAL-TGTGTINVIV--DDVNDNVPTF 2364

Query: 264  SASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTGVIKL 323
            ++ A+  ++ E++P  T V  V  +DAD    N    I+GGN     +F I P TG I  
Sbjct: 2365 ASKAYFTTIPEDAPTGTDVLLVNASDAD-ASKNAVIRIIGGN----SQFTINPSTGQIIT 2419

Query: 324  LDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPHLET 383
               L+RE +  Y + V  +D  +   P+PL   S +  V ++V ++ND PP        T
Sbjct: 2420 SALLDRETKDNYTLVVVCSDAGS---PEPL---SSSTSVLVTVTDVNDNPPRFQHHPYVT 2473

Query: 384  QIYSTV--ESFHSAQLFSKD--SPQEHLSYSIVGEQDE 417
             I S     SF  A   +     P   L YS+ G   E
Sbjct: 2474 HIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSE 2511



 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 69/258 (26%), Positives = 117/258 (45%), Gaps = 41/258 (15%)

Query: 135 RPFPLDS--INVTEKKSVGEIIARVKATDRDEDS-----SIIYSFKTQQKMFCLDPFTGT 187
           R FP  S   +V E   VG ++A +  TD D  +     S+      +Q+ F        
Sbjct: 356 RYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHF-------- 407

Query: 188 ITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGA--A 245
              +Q   + N S  K+ S    A D      SY  TV   +V D     P  +  A  +
Sbjct: 408 --EVQSSKVPNLSLIKVAS----ALDR-ERIPSYNLTV---SVSDNYGAPPGAAVQARSS 457

Query: 246 IITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGG 304
           + ++++ V+ IN+  P+ S   +  ++ E +P  + V  ++ TD D   N N+ Y+IV G
Sbjct: 458 VASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSG 517

Query: 305 N-LGTPPKFYIEPDTGVIKLLDS--LNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQ 361
           N LG    F+I   +G++    S  L+RE+ SQ  + +   D         +  +   AQ
Sbjct: 518 NGLGW---FHISEHSGLVTTGSSGGLDRELASQIVLNISARD-------QGVHPKVSYAQ 567

Query: 362 VTISVLNMNDEPPVCNPP 379
           + +++L++NDE PV + P
Sbjct: 568 LVVTLLDVNDEKPVFSQP 585



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 66/284 (23%), Positives = 120/284 (42%), Gaps = 49/284 (17%)

Query: 137  FPLDSINVTEKKSVGE--IIARVKATDRDEDSSIIYSF---KTQQKMFCLDPFTGTITLL 191
            FP D +++T ++++G+   I ++ A D DE ++ + ++         F +DP +G   L+
Sbjct: 1740 FPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESG--DLI 1797

Query: 192  QPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIV 251
                LD    SK YSL   A D+G  +S                           + + +
Sbjct: 1798 ATRRLDRERRSK-YSLLVRA-DDGLQSSD--------------------------MRINI 1829

Query: 252  RVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPK 311
             VS +N+  P  S   ++F + E++   +LV  +  TD D   N  E T +         
Sbjct: 1830 TVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNG-EITYIVNEDDEDGI 1888

Query: 312  FYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMND 371
            F++ P TGV  L   L+ E++  Y + V+  D            +  T +V  ++L++ND
Sbjct: 1889 FFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGG---------QFTTIRVYFNILDVND 1939

Query: 372  EPPVCNPPHLETQIYSTVESFHSAQLF----SKDSPQEHLSYSI 411
             PP+ +     T +   +    +  +F    + D     L+YSI
Sbjct: 1940 NPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSI 1983



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 80/356 (22%), Positives = 132/356 (37%), Gaps = 88/356 (24%)

Query: 36   IMAGSGVITATKIFNYETDPIRFLLIVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGT 95
            I + +G++T  K  +YE                +H +TI+ ID        A   + S T
Sbjct: 3139 INSSTGILTLAKALDYEL-------------CQKHEMTISAID----GGWVARTGYCSVT 3181

Query: 96   AT-LEIDEDYPLFQSIYRVTATDEVFANGDRLNVGGDHCARPFPLDSINVTEKKSVGEII 154
               ++++++ P+F S       D+ F                       V E    G  +
Sbjct: 3182 VNVIDVNDNSPVFLS-------DDYFPT---------------------VLENAPSGTTV 3213

Query: 155  ARVKATDRDEDSSIIYSFKTQQK---MFCLDPFTGTITLLQPLNLDNPSNSKIYSLETEA 211
              + ATD D  ++ + ++  Q     +F +DP TG IT                   T+ 
Sbjct: 3214 IHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVIT-------------------TQG 3254

Query: 212  TDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFS 271
              +     SY  TV   NV D   C        +  TV +++   NE  P   +  + F 
Sbjct: 3255 FLDFETKQSYHLTVKAFNVPDEERC--------SFATVNIQLKGTNEYVPRFVSKLYYFE 3306

Query: 272  VFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREI 331
            + E +P  T+VG+V  +D D   +   + ++ GN      F I   TG I +   L+RE 
Sbjct: 3307 ISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGN-SRKKGFQINKKTGQIYVSGILDREK 3365

Query: 332  ESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPHLETQIYS 387
            E +  + V   +  +    D          V ++VL+ ND      PP     IYS
Sbjct: 3366 EERVSLKVLAKNFGSIRGAD-----IDEVTVNVTVLDAND------PPIFTLNIYS 3410



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 60/239 (25%), Positives = 101/239 (42%), Gaps = 42/239 (17%)

Query: 141  SINVTEKKSVGEIIARVKATDRDE--DSSIIYSFKT--QQKMFCLDPFTGTITLLQPLNL 196
            S  + E  S+G I+  V A DRD   +  I YS  +  ++ +F ++  TG +TL + L+ 
Sbjct: 3095 SATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDY 3154

Query: 197  DNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRI 256
            +     + + +   A D G                        +       +V V V  +
Sbjct: 3155 E---LCQKHEMTISAIDGG------------------------WVARTGYCSVTVNVIDV 3187

Query: 257  NELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN-MEYTIVGGNLGTPPKFYIE 315
            N+ +P+  +  +  +V EN+P  T V  +  TDAD   N  + YT+   +      F I+
Sbjct: 3188 NDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSD---SDLFVID 3244

Query: 316  PDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
            P+TGVI     L+ E +  Y + VK  +     +PD   +R   A V I +   N+  P
Sbjct: 3245 PNTGVITTQGFLDFETKQSYHLTVKAFN-----VPD--EERCSFATVNIQLKGTNEYVP 3296



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 57/242 (23%), Positives = 104/242 (42%), Gaps = 37/242 (15%)

Query: 142 INVTEKKSVGEIIARVKATDRDE--DSSIIYSFKTQQKM--FCLDPFTGTITLLQPLNLD 197
           +N++E+   G  ++ + ATD D   ++++ YS  +   +  F +   +G +T      LD
Sbjct: 482 VNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLD 541

Query: 198 NPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRIN 257
               S+I  L   A D G +                    P  S    ++T++     +N
Sbjct: 542 RELASQIV-LNISARDQGVH--------------------PKVSYAQLVVTLL----DVN 576

Query: 258 ELNPIGSA-SAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEP 316
           +  P+ S    +  SV EN+P  T +  +  TD D   N      +         F ++P
Sbjct: 577 DEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDP 636

Query: 317 DTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVC 376
            +G +  + SL+RE ++ Y + V  TDL +         +S  A++ +S+L++ND  PV 
Sbjct: 637 VSGRLSTISSLDREEQAFYSLLVLATDLGSP-------PQSSMARINVSLLDINDNSPVF 689

Query: 377 NP 378
            P
Sbjct: 690 YP 691



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 59/226 (26%), Positives = 94/226 (41%), Gaps = 47/226 (20%)

Query: 154  IARVKATDRDEDSSIIYSFK----TQQKMFCLDPFTGTITLLQPLNLDNPSNSKIYSLET 209
            I  V A D+D   +    ++      +  F ++  TG I  ++PL+ +  S+   Y L  
Sbjct: 2687 ILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSH---YVLTI 2743

Query: 210  EATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAFT 269
            +++D G+ + S +  V +  +D+  +  P FS                          F+
Sbjct: 2744 KSSDKGSPSQSTSVKVMINILDENDNA-PRFS------------------------QIFS 2778

Query: 270  FSVFENSPVDTLVGKVTFTDADWPFNNME-YTIVGGNLGTPPKFYIEPDTGVIKLLDSLN 328
              V ENSP+   V +VT +D D   N +  Y+I+  +L     F I P TG I +   LN
Sbjct: 2779 AHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASL----PFTINPSTGDIVISRPLN 2834

Query: 329  REIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
            RE   +Y+I V   D       D          VTI V ++ND  P
Sbjct: 2835 REDTDRYRIRVSAHDSGWTVSTD----------VTIFVTDINDNAP 2870



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 60/238 (25%), Positives = 98/238 (41%), Gaps = 41/238 (17%)

Query: 141  SINVTEKKSVGEIIARVKATDRDEDSS-----IIYSFKTQQKMFCLDPFTGTITLLQPLN 195
            S+ ++E   +G  +  V A D D   S            +   F ++P TG IT+   L+
Sbjct: 3410 SVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELD 3469

Query: 196  LDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSR 255
             +      IY+L   A D+G                      PS +TG+A  +++V +  
Sbjct: 3470 RET---LPIYNLSVLAVDSGT---------------------PS-ATGSA--SLLVTLED 3502

Query: 256  INELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIE 315
            IN+  P+ + S     V EN    TLV  +  TD D P N   +T    + G    ++  
Sbjct: 3503 INDNGPMLTVSEG--EVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSL 3560

Query: 316  PDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
               GV+     ++RE  + + ++V   D     +P    Q S T  V I+V++ ND P
Sbjct: 3561 STAGVLSTTREIDREQIADFYLSVVTKD---SGVP----QMSSTGTVHITVIDQNDNP 3611



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 70/249 (28%), Positives = 111/249 (44%), Gaps = 41/249 (16%)

Query: 137 FPLDSINVT--EKKSVGEIIARVKATDRDEDSSII--YSFK----TQQKMFCLDPFTGTI 188
           FP  SI VT  E  S G  +    ATD D  S+ +   S++     +   F LD     I
Sbjct: 135 FPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLD-----I 189

Query: 189 TLLQPLNLDNPSNSKIY-SLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAII 247
           TL       NPS    +  L ++   +   T  Y   V VE+  +P             +
Sbjct: 190 TL-------NPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEP--------KRRGYL 234

Query: 248 TVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNL 306
            V V V  IN+  P+  +S +   V E++ V + V +V   DAD   N ++ Y +   + 
Sbjct: 235 QVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQ--DE 292

Query: 307 GTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISV 366
           GTP  F ++P+TG+I + + L+ E   QY + V+  D    ++       +G A+  I +
Sbjct: 293 GTP--FQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSL-------TGRAEALIQL 343

Query: 367 LNMNDEPPV 375
           L++ND  PV
Sbjct: 344 LDVNDNDPV 352



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 60/233 (25%), Positives = 97/233 (41%), Gaps = 43/233 (18%)

Query: 146  EKKSVGEIIARVKATD-RDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNSKI 204
            E + V  ++  +  +  R E  S   +       F +D  TG +++ QPL+ +       
Sbjct: 2578 ENQPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQK--- 2634

Query: 205  YSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAI-ITVIVRVSRINELNPIG 263
            Y +  EA D G                      P FS+   + ITV+     +N+  PI 
Sbjct: 2635 YVVWIEARDGG---------------------FPPFSSYEKLDITVL----DVNDNAPIF 2669

Query: 264  SASAFTFSVFEN-SPVDTLVGKVTFTDAD-WPFNNMEYTIVGGNLGTPPKFYIEPDTGVI 321
                F   + EN SP   L   V+  D D  P   ++Y IV GN+     F I   TG I
Sbjct: 2670 KEDPFISEILENLSPRKILT--VSAMDKDSGPNGQLDYEIVNGNMEN--SFSINHATGEI 2725

Query: 322  KLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
            + +  L+RE  S Y + +K +D  + +       +S + +V I++L+ ND  P
Sbjct: 2726 RSVRPLDREKVSHYVLTIKSSDKGSPS-------QSTSVKVMINILDENDNAP 2771



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 55/233 (23%), Positives = 91/233 (39%), Gaps = 39/233 (16%)

Query: 144  VTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNSK 203
            + E    G  +  V A+D D   + +         F ++P TG I     L+ +   N  
Sbjct: 2373 IPEDAPTGTDVLLVNASDADASKNAVIRIIGGNSQFTINPSTGQIITSALLDRETKDN-- 2430

Query: 204  IYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIG 263
             Y+L    +D G+               +P+S   S         V+V V+ +N+  P  
Sbjct: 2431 -YTLVVVCSDAGS--------------PEPLSSSTS---------VLVTVTDVNDNPPRF 2466

Query: 264  SASAFTFSVFENSPVDTLVGKVTFTDAD-WPFNNMEYTIVGGNLGTPPKFYIEPDTGVIK 322
                +   +   +   + V  VT TDAD  P + + Y++ G N     KF+I+P  G I 
Sbjct: 2467 QHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRN---SEKFHIDPLRGAIM 2523

Query: 323  LLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
                LN   E  + + VK    D  + P     ++ +  VT+  +N  D P V
Sbjct: 2524 AAGPLNGASEVTFSVHVK----DGGSFP-----KTDSTTVTVRFVNKADFPKV 2567



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 58/282 (20%), Positives = 113/282 (40%), Gaps = 51/282 (18%)

Query: 150  VGEIIARVKATDRDEDSSIIYSFKT---QQKMFCLDPFTGTITLLQPLNLDNPSNSKIYS 206
            +G ++  + A D DE ++    ++        F +D ++G + +   L      +  IY+
Sbjct: 1543 IGSVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASAL----VPSQLIYN 1598

Query: 207  LETEATDNG--NNTSSYTFTVFVENVDDPISCDPSFST----GAAIITVIVRVSRINELN 260
            L   ATD G     S+   T+ ++ +D P+   P + T    G  I T ++    I   +
Sbjct: 1599 LIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNVIS---IEAAS 1655

Query: 261  PIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTGV 320
            P GS +   + +      +  VG++                          F I   TG+
Sbjct: 1656 PRGSEAPVEYYIVSVRCEEKTVGRL--------------------------FTIGRHTGI 1689

Query: 321  IKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPH 380
            I+    L+RE  +   +        + A P     R+  A+V I++ ++ND PPV     
Sbjct: 1690 IQTAAILDREQGACLYLVDVYAIEKSTAFP-----RTQRAEVEITLQDINDNPPVFPTDM 1744

Query: 381  LETQIYSTV-ESFHSAQLFSKDSPQ---EHLSYSIVGEQDES 418
            L+  +   + +     QL + D+ +     ++Y+I+   D+S
Sbjct: 1745 LDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDS 1786



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 34/132 (25%), Positives = 60/132 (45%), Gaps = 14/132 (10%)

Query: 249  VIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNM-EYTIVGGNLG 307
            V + +  IN+  P+        +V EN    + + ++T  DAD   N +  YTI+ G   
Sbjct: 1726 VEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISG--- 1782

Query: 308  TPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVL 367
                F I+P++G +     L+RE  S+Y + V+  D            +S   ++ I+V 
Sbjct: 1783 ADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADD----------GLQSSDMRINITVS 1832

Query: 368  NMNDEPPVCNPP 379
            ++ND  P  + P
Sbjct: 1833 DVNDHTPKFSRP 1844



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 46/194 (23%), Positives = 82/194 (42%), Gaps = 27/194 (13%)

Query: 201 NSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELN 260
           NS   +L T +T +  +  S    + V      +S  P++ T   ++     V  +N+  
Sbjct: 84  NSSTGALYTTSTIDRESLPSDVINLVV------LSSAPTYPTEVRVL-----VRDLNDNA 132

Query: 261 PIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNME---YTIVGGNLGTPPKFYI--- 314
           P+    +   +  E+S     V   T TD+D   N ++   Y I+ GN     +  I   
Sbjct: 133 PVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLN 192

Query: 315 -EPDTGVIKLLDS--LNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMND 371
              +   + L+    L+RE+  QY++ V+V D           +R G  QV ++V ++ND
Sbjct: 193 PSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEP-------KRRGYLQVNVTVQDIND 245

Query: 372 EPPVCNPPHLETQI 385
            PPV    H +  +
Sbjct: 246 NPPVFGSSHYQAGV 259


>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
          Length = 1203

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 82/284 (28%), Positives = 123/284 (43%), Gaps = 46/284 (16%)

Query: 138 PLDSINVTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQKMFCLDPFTGTITLLQPLN 195
           P+  ++V+E    G  +  + ATD D  +++ I+Y        F LD  TG +T      
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTA----- 526

Query: 196 LDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSR 255
                 S+++  E +          + FTV   +   P    P  S  A I+TV+     
Sbjct: 527 ------SRVFDREEQ--------ERFIFTVTARDNGTP----PLQSQAAVIVTVLDE--- 565

Query: 256 INELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIE 315
            N+ +P  + + F F V EN P  + VG +T TDAD   N     +    L     F ++
Sbjct: 566 -NDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK---AVTLSILNDNDNFVLD 621

Query: 316 PDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
           P +GVIK   S +RE +S Y   VK TD            RS TA+VTI+V+++ND  PV
Sbjct: 622 PYSGVIKSNVSFDREQQSSYTFDVKATDGGQP-------PRSSTAKVTINVMDVNDNSPV 674

Query: 376 CNPPHLETQI----YSTVESFHSAQLFSKD---SPQEHLSYSIV 412
              P   T       S +     A++F+ D        L Y+IV
Sbjct: 675 VISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIV 718



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 72/285 (25%), Positives = 116/285 (40%), Gaps = 39/285 (13%)

Query: 136 PFPLDSINVTEKKSVGEIIARVKATDRDEDSSII--YSFKTQQKMFCLDPFTGTITLLQP 193
           P P+ +I++ E   +        ATD D   + +  Y     Q +F LD           
Sbjct: 143 PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDI---------- 192

Query: 194 LNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRV 253
             ++ P   K   L  +   +     +Y   + VE+   P        +  AI+ V V  
Sbjct: 193 --VETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQK------SSTAILQVTV-- 242

Query: 254 SRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPK-- 311
           S +N+  P+         + EN+PV T V ++  TDAD   N     I G  +    K  
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302

Query: 312 FYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMND 371
           F +   TG+I +  SL+RE  + +K+ V    L +D    P R     A VTI+V ++ND
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTV----LASDGSSTPAR-----ATVTINVTDVND 353

Query: 372 EPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQD 416
            PP  +  ++ + I  TV       L  KD     ++   V ++D
Sbjct: 354 NPPNIDLRYIISPINGTV------YLSEKDPVNTKIALITVSDKD 392



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 54/252 (21%), Positives = 108/252 (42%), Gaps = 40/252 (15%)

Query: 142 INVTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQ-----QKMFCLDPFTGTITLLQPL 194
           +++ E   VG  + ++ ATD D   ++ I Y F  Q     +++F L+  TG IT+ + L
Sbjct: 259 VHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL 318

Query: 195 NLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDD-PISCDPSFSTGAAIITVIVRV 253
           + +  +  K+  L   A+D  +  +  T T+ V +V+D P + D  +             
Sbjct: 319 DREETAIHKVTVL---ASDGSSTPARATVTINVTDVNDNPPNIDLRYI------------ 363

Query: 254 SRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFY 313
                ++PI      T  + E  PV+T +  +T +D D   N      +   +    K  
Sbjct: 364 -----ISPING----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAV 414

Query: 314 IEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
            + +  +++    L+ E   ++   +  +D    ++       + TA V + + + ND P
Sbjct: 415 YD-NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSL-------NQTALVRVKLEDENDNP 466

Query: 374 PVCNPPHLETQI 385
           P+ N P +E  +
Sbjct: 467 PIFNQPVIELSV 478



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 74/329 (22%), Positives = 124/329 (37%), Gaps = 93/329 (28%)

Query: 31  LGPN----QIMAGSGVITATKIFNYETDPIRFLLIV---DTGR---LYRHVLTINIIDVP 80
           LGPN     +   +GV+TA+++F+ E    RF+  V   D G      +  + + ++D  
Sbjct: 508 LGPNASFFDLDRKTGVLTASRVFDREEQE-RFIFTVTARDNGTPPLQSQAAVIVTVLD-- 564

Query: 81  ESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVFANGDRLNVGGDHCARPFPLD 140
           E+ N    PKF+       + E+ P + ++  +T TD                       
Sbjct: 565 ENDN---SPKFTHNHFQFFVSENLPKYSTVGVITVTD----------------------- 598

Query: 141 SINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPS 200
                               D  E+ ++  S       F LDP++G I     ++ D   
Sbjct: 599 -------------------ADAGENKAVTLSILNDNDNFVLDPYSGVIK--SNVSFDREQ 637

Query: 201 NSKIYSLETEATDNG----NNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRI 256
            S  Y+ + +ATD G    ++T+  T  V   N + P+   P  +T   ++ +       
Sbjct: 638 QSS-YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPL------- 689

Query: 257 NELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIE 315
                    SA   SV         V +V   D D   N  ++YTIV GN      F I+
Sbjct: 690 ---------SAIPGSV---------VAEVFAVDVDTGMNAELKYTIVSGN--NKGLFRID 729

Query: 316 PDTGVIKLLDSLNREIESQYKIAVKVTDL 344
           P TG I L +         +++ V ++DL
Sbjct: 730 PVTGNITLEEKPAPTDVGLHRLVVNISDL 758



 Score = 36.6 bits (83), Expect = 0.055
 Identities = 33/147 (22%), Positives = 67/147 (45%), Gaps = 17/147 (11%)

Query: 246 IITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEY------ 299
           +I + + V   N+  P+  +     S+ EN+ +++     + TD D  FN +++      
Sbjct: 125 LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184

Query: 300 -TIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSG 358
            ++ G ++   P+    P    + +  +L+RE +  Y + +KV D           Q+S 
Sbjct: 185 QSVFGLDIVETPEGEKWPQ---LIVQQNLDREQKDTYVMKIKVED-------GGTPQKSS 234

Query: 359 TAQVTISVLNMNDEPPVCNPPHLETQI 385
           TA + ++V ++ND  PV     +E  I
Sbjct: 235 TAILQVTVSDVNDNRPVFKEGQVEVHI 261


>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
          Length = 1237

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 82/284 (28%), Positives = 123/284 (43%), Gaps = 46/284 (16%)

Query: 138 PLDSINVTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQKMFCLDPFTGTITLLQPLN 195
           P+  ++V+E    G  +  + ATD D  +++ I+Y        F LD  TG +T      
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTA----- 526

Query: 196 LDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSR 255
                 S+++  E +          + FTV   +   P    P  S  A I+TV+     
Sbjct: 527 ------SRVFDREEQ--------ERFIFTVTARDNGTP----PLQSQAAVIVTVLDE--- 565

Query: 256 INELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIE 315
            N+ +P  + + F F V EN P  + VG +T TDAD   N     +    L     F ++
Sbjct: 566 -NDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK---AVTLSILNDNDNFVLD 621

Query: 316 PDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
           P +GVIK   S +RE +S Y   VK TD            RS TA+VTI+V+++ND  PV
Sbjct: 622 PYSGVIKSNVSFDREQQSSYTFDVKATDGGQP-------PRSSTAKVTINVMDVNDNSPV 674

Query: 376 CNPPHLETQI----YSTVESFHSAQLFSKD---SPQEHLSYSIV 412
              P   T       S +     A++F+ D        L Y+IV
Sbjct: 675 VISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIV 718



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 72/285 (25%), Positives = 116/285 (40%), Gaps = 39/285 (13%)

Query: 136 PFPLDSINVTEKKSVGEIIARVKATDRDEDSSII--YSFKTQQKMFCLDPFTGTITLLQP 193
           P P+ +I++ E   +        ATD D   + +  Y     Q +F LD           
Sbjct: 143 PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDI---------- 192

Query: 194 LNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRV 253
             ++ P   K   L  +   +     +Y   + VE+   P        +  AI+ V V  
Sbjct: 193 --VETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQK------SSTAILQVTV-- 242

Query: 254 SRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPK-- 311
           S +N+  P+         + EN+PV T V ++  TDAD   N     I G  +    K  
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302

Query: 312 FYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMND 371
           F +   TG+I +  SL+RE  + +K+ V    L +D    P R     A VTI+V ++ND
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTV----LASDGSSTPAR-----ATVTINVTDVND 353

Query: 372 EPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQD 416
            PP  +  ++ + I  TV       L  KD     ++   V ++D
Sbjct: 354 NPPNIDLRYIISPINGTV------YLSEKDPVNTKIALITVSDKD 392



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 54/252 (21%), Positives = 108/252 (42%), Gaps = 40/252 (15%)

Query: 142 INVTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQ-----QKMFCLDPFTGTITLLQPL 194
           +++ E   VG  + ++ ATD D   ++ I Y F  Q     +++F L+  TG IT+ + L
Sbjct: 259 VHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL 318

Query: 195 NLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDD-PISCDPSFSTGAAIITVIVRV 253
           + +  +  K+  L   A+D  +  +  T T+ V +V+D P + D  +             
Sbjct: 319 DREETAIHKVTVL---ASDGSSTPARATVTINVTDVNDNPPNIDLRYI------------ 363

Query: 254 SRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFY 313
                ++PI      T  + E  PV+T +  +T +D D   N      +   +    K  
Sbjct: 364 -----ISPING----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAV 414

Query: 314 IEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
            + +  +++    L+ E   ++   +  +D    ++       + TA V + + + ND P
Sbjct: 415 YD-NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSL-------NQTALVRVKLEDENDNP 466

Query: 374 PVCNPPHLETQI 385
           P+ N P +E  +
Sbjct: 467 PIFNQPVIELSV 478



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 74/329 (22%), Positives = 124/329 (37%), Gaps = 93/329 (28%)

Query: 31  LGPN----QIMAGSGVITATKIFNYETDPIRFLLIV---DTGR---LYRHVLTINIIDVP 80
           LGPN     +   +GV+TA+++F+ E    RF+  V   D G      +  + + ++D  
Sbjct: 508 LGPNASFFDLDRKTGVLTASRVFDREEQE-RFIFTVTARDNGTPPLQSQAAVIVTVLD-- 564

Query: 81  ESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVFANGDRLNVGGDHCARPFPLD 140
           E+ N    PKF+       + E+ P + ++  +T TD                       
Sbjct: 565 ENDN---SPKFTHNHFQFFVSENLPKYSTVGVITVTD----------------------- 598

Query: 141 SINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPS 200
                               D  E+ ++  S       F LDP++G I     ++ D   
Sbjct: 599 -------------------ADAGENKAVTLSILNDNDNFVLDPYSGVIK--SNVSFDREQ 637

Query: 201 NSKIYSLETEATDNG----NNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRI 256
            S  Y+ + +ATD G    ++T+  T  V   N + P+   P  +T   ++ +       
Sbjct: 638 QSS-YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPL------- 689

Query: 257 NELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIE 315
                    SA   SV         V +V   D D   N  ++YTIV GN      F I+
Sbjct: 690 ---------SAIPGSV---------VAEVFAVDVDTGMNAELKYTIVSGN--NKGLFRID 729

Query: 316 PDTGVIKLLDSLNREIESQYKIAVKVTDL 344
           P TG I L +         +++ V ++DL
Sbjct: 730 PVTGNITLEEKPAPTDVGLHRLVVNISDL 758



 Score = 36.6 bits (83), Expect = 0.055
 Identities = 33/147 (22%), Positives = 67/147 (45%), Gaps = 17/147 (11%)

Query: 246 IITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEY------ 299
           +I + + V   N+  P+  +     S+ EN+ +++     + TD D  FN +++      
Sbjct: 125 LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184

Query: 300 -TIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSG 358
            ++ G ++   P+    P    + +  +L+RE +  Y + +KV D           Q+S 
Sbjct: 185 QSVFGLDIVETPEGEKWPQ---LIVQQNLDREQKDTYVMKIKVED-------GGTPQKSS 234

Query: 359 TAQVTISVLNMNDEPPVCNPPHLETQI 385
           TA + ++V ++ND  PV     +E  I
Sbjct: 235 TAILQVTVSDVNDNRPVFKEGQVEVHI 261


>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
            sapiens]
          Length = 3014

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 84/298 (28%), Positives = 134/298 (44%), Gaps = 43/298 (14%)

Query: 94   GTATLEIDEDYPLFQS-IYRVTATDEVFANGDR--LNVGGDHCARPFPLDS---INVTEK 147
            G  TL +  DY   Q  +  VTA+D   ++     +NV   +  RP    S   ++V+E 
Sbjct: 742  GLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSED 801

Query: 148  KSVGEIIARVKATDRD--EDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNSKIY 205
            + VG  IA + A D D  E++ I Y  +     F +DP +GT+  +  L+ +N      Y
Sbjct: 802  RPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYEN---QVAY 858

Query: 206  SLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSA 265
            +L   A DNG    S T T+ +  +D                         N+  P    
Sbjct: 859  TLTIMAQDNGIPQKSDTTTLEILILD------------------------ANDNAPQFLW 894

Query: 266  SAFTFSVFENSPVDTLVGKVTFTDAD-WPFNNMEYTIVGGNLGTPPKFYIEPDTGVIKLL 324
              +  S+FE++P  T + +V+ TD D  P   + YT  GG+ G    FYIEP +GVI+  
Sbjct: 895  DFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDG-DGDFYIEPTSGVIRTQ 953

Query: 325  DSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPHLE 382
              L+RE  + Y +     D  +   P PL   S + ++ +++L++ND  P+     LE
Sbjct: 954  RRLDRENVAVYNLWALAVDRGS---PTPL---SASVEIQVTILDINDNAPMFEKDELE 1005



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 68/264 (25%), Positives = 112/264 (42%), Gaps = 53/264 (20%)

Query: 142 INVTEKKSVGEIIARVKATDRDE--DSSIIYSFKTQQK--MFCLDPFTGTITLLQPLNLD 197
           + V E   +   + RV+ATDRD+  +++I YS  +      F L   +G + ++ PL+ +
Sbjct: 466 VQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFE 525

Query: 198 NPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRIN 257
           +      YSL  +A D G                      P     + +++V  +V  +N
Sbjct: 526 DVQK---YSLSIKAQDGGR---------------------PPLINSSGVVSV--QVLDVN 559

Query: 258 ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIV--------GGNLG- 307
           +  PI  +S F  +V EN P+   V  +   DAD   N  + Y +V        GG+ G 
Sbjct: 560 DNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGP 619

Query: 308 -----TPP-KFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQ 361
                TP   F I   +G I +   L+RE    Y   V+  D  +  +       S +  
Sbjct: 620 KNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPM-------SSSTS 672

Query: 362 VTISVLNMNDEPPVCNPPHLETQI 385
           V+I+VL++ND  PV   P  E ++
Sbjct: 673 VSITVLDVNDNDPVFTQPTYELRL 696



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 58/241 (24%), Positives = 99/241 (41%), Gaps = 44/241 (18%)

Query: 138 PLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFK--TQQKMFCLDPFTG--TITLLQP 193
           P   + + E  +VG  +  ++A DRD +S I Y       +  F L    G   ITL  P
Sbjct: 690 PTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALP 749

Query: 194 LNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRV 253
           L+         Y L   A+D   + +++                           V++ V
Sbjct: 750 LDYKQEQQ---YVLAVTASDGTRSHTAH---------------------------VLINV 779

Query: 254 SRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFY 313
           +  N   P+  +S +T SV E+ PV T +  ++  D D   N     ++   +   P+F 
Sbjct: 780 TDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPV---PQFR 836

Query: 314 IEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
           I+PD+G +  +  L+ E +  Y + +   D   + IP    Q+S T  + I +L+ ND  
Sbjct: 837 IDPDSGTMYTMMELDYENQVAYTLTIMAQD---NGIP----QKSDTTTLEILILDANDNA 889

Query: 374 P 374
           P
Sbjct: 890 P 890



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 60/228 (26%), Positives = 102/228 (44%), Gaps = 44/228 (19%)

Query: 154  IARVKATDRDE--DSSIIYSFKTQQKM---FCLDPFTGTITLLQPLNLDNPSNSKIYSLE 208
            I +V ATDRD   +  ++Y+F+        F ++P +G I   + L+ +N +   +Y+L 
Sbjct: 911  ILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVA---VYNLW 967

Query: 209  TEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAF 268
              A D G+ T              P+S         A + + V +  IN+  P+      
Sbjct: 968  ALAVDRGSPT--------------PLS---------ASVEIQVTILDINDNAPMFEKDEL 1004

Query: 269  TFSVFENSPVDTLVGKVTFTDAD-WPFNNMEYTIVGGNLGTPPKFYIEPDTGVIKLLDSL 327
               V EN+PV ++V K+   D D  P   + Y IV G++     F ++   G ++ +  L
Sbjct: 1005 ELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDM--RHFFQLDLLNGDLRAMVEL 1062

Query: 328  NREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
            + E+  +Y + V+ T         PL  R   A V I +++ ND PPV
Sbjct: 1063 DFEVRREYVLVVQATSA-------PLVSR---ATVHILLVDQNDNPPV 1100



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 65/258 (25%), Positives = 108/258 (41%), Gaps = 43/258 (16%)

Query: 136 PFPLDSINVTEKKSVGEIIARVKA--TDRDEDSSIIYSFK-----TQQKMFCLDPFTGTI 188
           P P   + + E +  G +I ++ A  T   E+  + Y  +       +  F +D  TG +
Sbjct: 246 PMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAV 305

Query: 189 TLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIIT 248
                      S   +   ET+ T            + V+ VD   S  P  +T    IT
Sbjct: 306 -----------STDSVLDRETKETH----------VLRVKAVD--YSTPPRSAT--TYIT 340

Query: 249 VIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLG 307
           V+V+ +  N+ +P+   S +   V EN  V   V  +  +D D P N N+ Y ++GG   
Sbjct: 341 VLVKDT--NDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD 398

Query: 308 TPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVL 367
               F +   +GV+     L+RE  ++Y++ V+  D   +  P PL   S TA V I V 
Sbjct: 399 V---FQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRN--PGPL---SATATVYIEVE 450

Query: 368 NMNDEPPVCNPPHLETQI 385
           + ND  P  +  +   Q+
Sbjct: 451 DENDNYPQFSEQNYVVQV 468



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 34/152 (22%), Positives = 64/152 (42%), Gaps = 13/152 (8%)

Query: 268 FTFSVFENSPVDTLVGKV-TFTDADWPFNNMEYTIVG-GNLGTPPKFYIEPDTGVIKLLD 325
           +  ++FEN P  TL+ ++      +     + Y + G  +  +   F I+  TG +    
Sbjct: 250 YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDS 309

Query: 326 SLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPHLETQI 385
            L+RE +  + + VK  D            RS T  +T+ V + ND  PV        ++
Sbjct: 310 VLDRETKETHVLRVKAVDYSTPP-------RSATTYITVLVKDTNDHSPVFEQSEYRERV 362

Query: 386 YSTVESFH---SAQLFSKDSP-QEHLSYSIVG 413
              +E  +   + +   +DSP   +L Y ++G
Sbjct: 363 RENLEVGYEVLTIRASDRDSPINANLRYRVLG 394


>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
          Length = 794

 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 73/251 (29%), Positives = 109/251 (43%), Gaps = 33/251 (13%)

Query: 144 VTEKKSVGEIIARVKATDRDE-----DSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDN 198
           V E   VG  + +VKATD D+      + ++YS    Q  F +DP TG I    P N+D 
Sbjct: 169 VPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALP-NMDR 227

Query: 199 PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
               + Y +  +A D G        T  V                       + ++ +N+
Sbjct: 228 EVKEQ-YQVLIQAKDMGGQLGGLAGTTIVN----------------------ITLTDVND 264

Query: 259 LNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIEPD 317
             P    S F   V E+SP+ + +G++   D D+  N  +EY IV G+ G       + D
Sbjct: 265 NPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDED 324

Query: 318 T--GVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
           T  GVIKL   L+ E +  Y   V+ ++L  D           TA V ISVL++ DEPPV
Sbjct: 325 TQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDV-DEPPV 383

Query: 376 CNPPHLETQIY 386
            + P    ++Y
Sbjct: 384 FSKPLYTMEVY 394



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 42/126 (33%), Positives = 66/126 (52%), Gaps = 6/126 (4%)

Query: 250 IVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTP 309
           I++V  IN+  P      +  +V E SPV   V +V  TDAD P       +V   L   
Sbjct: 147 IIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQ 206

Query: 310 PKFYIEPDTGVIK-LLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLN 368
           P F I+P TGVI+  L +++RE++ QY++ ++  D+        L   +GT  V I++ +
Sbjct: 207 PYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQ-----LGGLAGTTIVNITLTD 261

Query: 369 MNDEPP 374
           +ND PP
Sbjct: 262 VNDNPP 267



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 67/268 (25%), Positives = 117/268 (43%), Gaps = 30/268 (11%)

Query: 136 PFPLDSINVTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQKMFCLDPFTGTITLLQP 193
           P  +  + V E   +G  I R++A D D  +++ I Y+          D  T   T    
Sbjct: 270 PKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGV 329

Query: 194 LNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF-STGAAIITVIVR 252
           + L  P +      ET+         +YTF V   N    +  D  F S G    T  V+
Sbjct: 330 IKLKKPLD-----FETK--------KAYTFKVEASN----LHLDHRFHSAGPFKDTATVK 372

Query: 253 VSRIN-ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPK 311
           +S ++ +  P+ S   +T  V+E++PV T++G VT  D D   + + Y I   + G    
Sbjct: 373 ISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDG-DSY 431

Query: 312 FYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMND 371
           F I+ + G I   + L+RE  +QY  ++  + + N  +       +    + I+VL++N+
Sbjct: 432 FTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLL-------TSKVNILINVLDVNE 484

Query: 372 EPPVCNPPHLETQIYSTVESFHSAQLFS 399
            PP  + P+ ET +    +     Q+ S
Sbjct: 485 FPPEISVPY-ETAVCENAKPGQIIQIVS 511


>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
          Length = 4588

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 102/359 (28%), Positives = 156/359 (43%), Gaps = 66/359 (18%)

Query: 86   TADPKFS----SGTATLEIDEDYPLFQSIY-------------RVTATDEVFANGDRLNV 128
            +AD +FS    SG   LE   D  L Q++Y             R+TAT  V  +   L++
Sbjct: 3167 SADGQFSINELSGIIQLEKPLDREL-QAVYTLSLKAVDQGLPRRLTATGTVIVSV--LDI 3223

Query: 129  GGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSS--IIYSFKT--QQKMFCLDPF 184
              +     +      V+E   VG  + +V A  RD +++  I YS  +  +   F +D  
Sbjct: 3224 NDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK 3283

Query: 185  TGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGA 244
            TG + +++  NLD  S+ + Y L  EATD G                      PS S   
Sbjct: 3284 TGAVFIIE--NLDYESSHEYY-LTVEATDGGT---------------------PSLSD-- 3317

Query: 245  AIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVG 303
             + TV V V+ IN+  P+ S   +T  + E++ ++  V  V   DAD P N ++ Y+I+ 
Sbjct: 3318 -VATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIID 3376

Query: 304  GNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVT 363
            GN G+   F I+P  G +K+   L+RE  S Y + V+ +  DN + P     R  T  V 
Sbjct: 3377 GNQGS--SFTIDPVRGEVKVTKLLDRETISGYTLTVQAS--DNGSPP-----RVNTTTVN 3427

Query: 364  ISVLNMNDEPPVCNPPHLETQIYSTVE-SFHSAQLFSKDSPQEH----LSYSIVGEQDE 417
            I V ++ND  PV +  +    I       F   QL   D    H      ++IV   DE
Sbjct: 3428 IDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDE 3486



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 75/274 (27%), Positives = 127/274 (46%), Gaps = 51/274 (18%)

Query: 113  VTATDEVFANGDRLNV-------GGDHCARPFPLDSINVTEKKSVGEIIARVKATDRD-- 163
            +TATD  F++   + V           C +    D+I   E    G++I ++ ATD D  
Sbjct: 2996 ITATDGTFSSKAIVEVKVLDANDNSPVCEKTLYSDTI--PEDVLPGKLIMQISATDADIR 3053

Query: 164  EDSSIIYSFK-TQQKMFCLDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYT 222
             ++ I Y+   +  + F L+P TG +    PL+ +  +   +Y L   ATD G      +
Sbjct: 3054 SNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQA---VYHLLVRATDGGGRFCQAS 3110

Query: 223  FTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLV 282
              + +E+V+D     P F                       SA  +  +VFEN+   TL+
Sbjct: 3111 IVLTLEDVNDNA---PEF-----------------------SADPYAITVFENTEPGTLL 3144

Query: 283  GKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKV 341
             +V  TDAD   N  + Y+++    G   +F I   +G+I+L   L+RE+++ Y +++K 
Sbjct: 3145 TRVQATDADAGLNRKILYSLIDSADG---QFSINELSGIIQLEKPLDRELQAVYTLSLKA 3201

Query: 342  TDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
             D     +P   R+ + T  V +SVL++ND PPV
Sbjct: 3202 VD---QGLP---RRLTATGTVIVSVLDINDNPPV 3229



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 57/196 (29%), Positives = 95/196 (48%), Gaps = 35/196 (17%)

Query: 154  IARVKATDRDEDSSIIYSFKTQQ-----KMFCLDPFTGTITLLQPLNLDNPSNSKIYSLE 208
            I ++ A D+DE + +IY+ ++ +     K F LDP TG++   +              L+
Sbjct: 1475 ILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSE-------------KLD 1521

Query: 209  TEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAF 268
             EA         +T TV V + D P+  +           ++V VS  N+  P  +AS++
Sbjct: 1522 HEAVHQ------HTLTVMVRDQDVPVKRN--------FARIVVNVSDTNDHAPWFTASSY 1567

Query: 269  TFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIEPDTGVIKLLDSL 327
               V+E++ V ++V +VT  D D   N  + Y+I  GN+G    F I+P  G IK    L
Sbjct: 1568 KGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGN--SFMIDPVLGSIKTAKEL 1625

Query: 328  NREIESQYKIAVKVTD 343
            +R  +++Y + VK TD
Sbjct: 1626 DRSNQAEYDLMVKATD 1641



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 80/297 (26%), Positives = 129/297 (43%), Gaps = 44/297 (14%)

Query: 150 VGEIIARVKATDRDEDSSIIYSFKTQQKM--FCLDPFTGTITLLQPLNLDNPSNSKIYSL 207
           VGE I  V A D DE   + Y  +   ++  F L+P +G ++L + L     +    +SL
Sbjct: 584 VGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSL 643

Query: 208 ETEATDNGNNTSSY--TFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSA 265
              ATD  N  +      TV   +    + C+    TG A + +  ++ + N+L+  G  
Sbjct: 644 RITATDGENFATPLYINITVAASHKLVNLQCE---ETGVAKM-LAEKLLQANKLHNQGEV 699

Query: 266 SAFTFS--------------------VFENSPVDTLVGKVTFTDADWPFNN-MEYTIVGG 304
               F                     V EN PV + V  +  TD D  FN  + Y + GG
Sbjct: 700 EDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGG 759

Query: 305 NLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTI 364
           N  +   F I+ +TG++K+L  L+RE   +Y + + V DL    IP    Q++    + +
Sbjct: 760 NEDSC--FMIDMETGMLKILSPLDRETTDKYTLNITVYDL---GIP----QKAAWRLLHV 810

Query: 365 SVLNMNDEPPVCNPPHLETQIYSTVESFHS----AQLFSKD-SPQEHLSYSIVGEQD 416
            V++ ND PP         ++ S  +  HS     +   KD  P  H++YSIV + D
Sbjct: 811 VVVDANDNPPEFLQESYFVEV-SEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 73/292 (25%), Positives = 120/292 (41%), Gaps = 55/292 (18%)

Query: 138  PLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQ--KMFCLDPFTGTITLLQPLN 195
            P  S  + E   V   +  V+A    E   + YS         F ++  TG I ++ PL+
Sbjct: 2185 PFYSAEIAESIQVHSPVVHVQANS-PEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLD 2243

Query: 196  LD-NPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVS 254
             + +P+    Y L   ATD+     +  F   +  VDD                      
Sbjct: 2244 FEAHPA----YKLSIRATDSLTGAHAEVFVDII--VDD---------------------- 2275

Query: 255  RINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADW-PFNNMEYTIVGGNLGTPPKFY 313
             IN+  P+ +  ++  ++ E S + T V +V  TD+D  P   + Y + G +  +   F+
Sbjct: 2276 -INDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFH 2334

Query: 314  IEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
            ++  TG+I LL +L+ E   Q+ I V+       A+   +   S    VT+ V ++ND  
Sbjct: 2335 VDSSTGLISLLRTLDYEQSRQHTIFVR-------AVDGGMPTLSSDVIVTVDVTDLND-- 2385

Query: 374  PVCNPPHLETQIYSTVESFHS--------AQLFSKDSPQ-EHLSYSIVGEQD 416
               NPP  E QIY    S H+         + +  DS   + L YSI+   D
Sbjct: 2386 ---NPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGND 2434



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 78/306 (25%), Positives = 127/306 (41%), Gaps = 65/306 (21%)

Query: 146  EKKSVGEIIARVKATDRDE--DSSIIYSFK--TQQKMFCLDPFTGTITLLQPLNLDNPSN 201
            E+ +  E +  V ATD+DE  ++ I YS +   +   F ++P TG ++            
Sbjct: 1263 ERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVS------------ 1310

Query: 202  SKIYS-------LETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVS 254
            SK +S       L  +A DNG    S T  + +E +  P    PS               
Sbjct: 1311 SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKP---KPS--------------- 1352

Query: 255  RINELNPIG-SASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFY 313
                L PI    S FTF+V E+ PV  ++G ++      P   + + I GGN  +   F 
Sbjct: 1353 ----LEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIP---LWFDITGGNYDS--HFD 1403

Query: 314  IEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
            ++  TG I +   L+ E +S Y + V+ TD     +           QV I V++ ND  
Sbjct: 1404 VDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL----------TQVFIKVIDTNDHR 1453

Query: 374  PVCNPPHLETQI-YSTVESFHSAQLFSKDSPQEH-LSYSIVGEQD--ESRKKRLEKMSLS 429
            P  +    E  I   T       Q+ + D  +++ L Y++   +D    +K RL+  + S
Sbjct: 1454 PQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGS 1513

Query: 430  SYYFKK 435
             Y  +K
Sbjct: 1514 LYTSEK 1519



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 74/288 (25%), Positives = 117/288 (40%), Gaps = 63/288 (21%)

Query: 144  VTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQKM--FCLDPFTGTITLLQPLNLDNP 199
            V E   VG ++  V A D D   D  I YS +    +  F +   TG I           
Sbjct: 1043 VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVI----------- 1091

Query: 200  SNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINEL 259
                    ET    +  +TS Y  TVF        + D      ++ I + + V  +N+ 
Sbjct: 1092 --------ETSDRLDRESTSHYWLTVF--------ATDQGVVPLSSFIEIYIEVEDVNDN 1135

Query: 260  NPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN-MEYTIVGGNLGTPPKFY-IEPD 317
             P  S   +   + ENSP D  V ++   D D   N+ + Y I  GN   P  F+ I P 
Sbjct: 1136 APQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGN---PQGFFSIHPK 1192

Query: 318  TGVIKLLD-SLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVC 376
            TG+I      L+RE + ++ + V VT  DN + P     +S  A+V + +L+ ND  P  
Sbjct: 1193 TGLITTTSRKLDREQQDEHILEVTVT--DNGSPP-----KSTIARVIVKILDENDNKP-- 1243

Query: 377  NPPHLETQIYSTVESFHSAQLFSKDSP-------QEHLSYSIVGEQDE 417
                        ++ F+  +L  ++ P       +E L + I  ++DE
Sbjct: 1244 ----------QFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDE 1281



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 58/282 (20%), Positives = 111/282 (39%), Gaps = 48/282 (17%)

Query: 142  INVTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNP 199
            + V+E K V   I +V+ATD+D   +  + YS  T    F +D  TG + + +PL+ +  
Sbjct: 829  VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQ 888

Query: 200  SNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINEL 259
                 +SL+ EA D          TV V+                      V +  +N+ 
Sbjct: 889  HE---HSLKIEARDQAREEPQLFSTVVVK----------------------VSLEDVNDN 923

Query: 260  NPIGSASAFTFSVFENSPVDTLVGKVTFTDAD-WPFNNMEYTIVGGNLGTPPKFYIEPDT 318
             P      +   V E+ P  T++  +   D D      + Y+++    G    F ++  +
Sbjct: 924  PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEG---NFDVDKLS 980

Query: 319  GVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNP 378
            G ++++  L+ E +  Y + V+  D             S T  V + V+++N+     +P
Sbjct: 981  GAVRIVQQLDFEKKQVYNLTVRAKDKGKPV------SLSSTCYVEVEVVDVNEN---LHP 1031

Query: 379  PHLETQIYSTVESFHSAQLFSKDSPQEHLSYSIVGEQDESRK 420
            P           SF       +D+P   L  ++    +++R+
Sbjct: 1032 P--------VFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARR 1065



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 66/244 (27%), Positives = 106/244 (43%), Gaps = 41/244 (16%)

Query: 142  INVTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQ-QKMFCLDPFTGTITLLQPLNLDN 198
            + V E    G +I  ++A D D  +   + YS     +  F +D  +G + ++Q L+ + 
Sbjct: 934  VKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEK 993

Query: 199  PSNSKIYSLETEATDNGNNTS-SYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRIN 257
                ++Y+L   A D G   S S T  V VE VD   +  P                   
Sbjct: 994  ---KQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHP------------------- 1031

Query: 258  ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN-MEYTIVGGN-LGTPPKFYIE 315
               P+ S+     +V E++PV +LV  V+  D D   +  + Y+I  G+ +G    F I 
Sbjct: 1032 ---PVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGV---FKIG 1085

Query: 316  PDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
             +TGVI+  D L+RE  S Y + V  T  D   +P      S   ++ I V ++ND  P 
Sbjct: 1086 EETGVIETSDRLDRESTSHYWLTVFAT--DQGVVP-----LSSFIEIYIEVEDVNDNAPQ 1138

Query: 376  CNPP 379
             + P
Sbjct: 1139 TSEP 1142



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 48/211 (22%), Positives = 89/211 (42%), Gaps = 39/211 (18%)

Query: 179  FCLDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDP 238
            F +D  TGTI + +PL+ +  SN   Y+L  EATD                         
Sbjct: 1402 FDVDKGTGTIIVAKPLDAEQKSN---YNLTVEATD------------------------- 1433

Query: 239  SFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNME 298
               T   +  V ++V   N+  P  S S +   + E++  +T + +++  D D   N + 
Sbjct: 1434 --GTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD-EKNKLI 1490

Query: 299  YTIVGG-NLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRS 357
            YT+    +  +  KF ++P TG +   + L+ E   Q+ + V V D D       +  + 
Sbjct: 1491 YTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQD-------VPVKR 1543

Query: 358  GTAQVTISVLNMNDEPPVCNPPHLETQIYST 388
              A++ ++V + ND  P       + ++Y +
Sbjct: 1544 NFARIVVNVSDTNDHAPWFTASSYKGRVYES 1574



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 58/245 (23%), Positives = 103/245 (42%), Gaps = 51/245 (20%)

Query: 144  VTEKKSVGEIIARVKATDRDEDSS--IIYSFKTQQKMFCLDPF-----TGTITLLQPLNL 196
            + E    G  + +++A+D D  ++  ++YS    Q +  ++ F     TG IT L+ L+ 
Sbjct: 2818 IVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDH 2877

Query: 197  DNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRI 256
            +   N   Y ++  A+D+G      +  +                       V V V+ +
Sbjct: 2878 EKRDN---YQIKVVASDHGEKIQLSSTAI-----------------------VDVTVTDV 2911

Query: 257  NELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNME--YTIVGGN-LGTPPKFY 313
            N+  P  +A  +  +V E+ P   ++  ++ TDAD    N +  Y I GG+ LG   +F 
Sbjct: 2912 NDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLG---QFA 2968

Query: 314  IE--PDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMND 371
            +E   +   + +   L+RE    Y + +  TD             S  A V + VL+ ND
Sbjct: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDAND 3018

Query: 372  EPPVC 376
              PVC
Sbjct: 3019 NSPVC 3023



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 60/255 (23%), Positives = 108/255 (42%), Gaps = 49/255 (19%)

Query: 141  SINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQK--MFCLDPFTGTITLLQPLNLDN 198
            S+ ++E  S+G  +  V A  +   SS++Y  K       F ++P +GTI   + L+ + 
Sbjct: 1673 SVELSETVSIGSFVGMVTAHSQ---SSVVYEIKDGNTGDAFDINPHSGTIITQKALDFET 1729

Query: 199  PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
                 IY+L  + T+    +++                           TV+V +   N+
Sbjct: 1730 ---LPIYTLIIQGTNMAGLSTN--------------------------TTVLVHLQDEND 1760

Query: 259  LNPIGSASAFTFSVFENSPVDTLVGK-------VTFTDADWPFNNM-EYTIVGGNLGTPP 310
              P+   + +T  + E++ ++++V         +   DAD   N +  Y IV  ++ T  
Sbjct: 1761 NAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHT-- 1818

Query: 311  KFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMN 370
             F I+  TG I  + SL+ E  S +   V+V D+       P       A VT+ V+++N
Sbjct: 1819 YFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGT-----PRLFAEYAANVTVHVIDIN 1873

Query: 371  DEPPVCNPPHLETQI 385
            D PPV   P  E  +
Sbjct: 1874 DCPPVFAKPLYEASL 1888



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 60/264 (22%), Positives = 108/264 (40%), Gaps = 47/264 (17%)

Query: 144  VTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQ--KMFCLDPFTGTITLLQPLNLDNP 199
            V E  +VG ++ +V A D+D  +++ ++YS ++      F +DP  G+I   + L   + 
Sbjct: 1571 VYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKEL---DR 1627

Query: 200  SNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINEL 259
            SN   Y L  +ATD G+   S                         I +V + V+  +  
Sbjct: 1628 SNQAEYDLMVKATDKGSPPMS------------------------EITSVRIFVTIADNA 1663

Query: 260  NPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTG 319
            +P  ++  ++  + E   + + VG VT        +++ Y I  GN G    F I P +G
Sbjct: 1664 SPKFTSKEYSVELSETVSIGSFVGMVTAHSQ----SSVVYEIKDGNTG--DAFDINPHSG 1717

Query: 320  VIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPP 379
             I    +L+ E    Y + ++ T++            S    V + + + ND  PV    
Sbjct: 1718 TIITQKALDFETLPIYTLIIQGTNMAG---------LSTNTTVLVHLQDENDNAPVFMQA 1768

Query: 380  HLETQIYSTVESFHSAQLFSKDSP 403
               T + S   S +S  L  ++ P
Sbjct: 1769 EY-TGLISESASINSVVLTDRNVP 1791



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 43/170 (25%), Positives = 74/170 (43%), Gaps = 15/170 (8%)

Query: 207  LETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSAS 266
            L+ E + +   T  Y F++          C        A + V ++V   N+ +P+  +S
Sbjct: 2760 LKLEKSLDHETTKWYQFSILAR-------CTQDDHEMVASVDVSIQVKDANDNSPVFESS 2812

Query: 267  AFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTI-VGGNLGTPPKFYIEPDTGVIKLL 324
             +   + EN P  + V ++  +DAD   N  + Y++    ++     F I  +TG I  L
Sbjct: 2813 PYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTL 2872

Query: 325  DSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
              L+ E    Y+I V  +D           Q S TA V ++V ++ND PP
Sbjct: 2873 KELDHEKRDNYQIKVVASDHGEKI------QLSSTAIVDVTVTDVNDSPP 2916



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 45/171 (26%), Positives = 72/171 (42%), Gaps = 31/171 (18%)

Query: 141 SINVTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDN 198
           S+++ E  ++   IARV ATD D   +    YSFK +  MF + P +G I L   L+   
Sbjct: 155 SVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDY-- 212

Query: 199 PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTG-AAIITVIVRVSRIN 257
              +K+Y +E  A D G                         S+G +++  + V + + N
Sbjct: 213 -LETKLYEMEILAADRGMKLYG--------------------SSGISSMAKLTVHIEQAN 251

Query: 258 ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN--MEYTIVGGNL 306
           E  P+ +A   + S  +  P   +   VT  D D   N      +IV G+L
Sbjct: 252 ECAPVITAVTLSPSELDRDPAYAI---VTVDDCDQGANGDIASLSIVAGDL 299



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 73/296 (24%), Positives = 115/296 (38%), Gaps = 52/296 (17%)

Query: 144  VTEKKSVGEIIARVKATDRDEDS--SIIYSFKT--QQKMFCLDPFTGTITLLQPLNLDNP 199
            ++E    G  +  VKA D D      + YS  +    K F +D  TG ITL    NL   
Sbjct: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLS---NLHRH 2455

Query: 200  SNSKIYSLETEATDNGNNTSSYTF-TVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
            +    YSL    +D    +S+    TV   N+  P      +    A             
Sbjct: 2456 ALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELA------------- 2502

Query: 259  LNPIGSASAFTFSVFENSPVDTLVGKVTFTDAD-WPFNNMEYTIVGGNLGTPPKFYIEPD 317
                           EN+P+ TLV +V  TD D   + ++ Y IV  N     +FYI  +
Sbjct: 2503 ---------------ENAPLHTLVMEVKTTDGDSGIYGHVTYHIV--NDFAKDRFYIN-E 2544

Query: 318  TGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCN 377
             G I  L+ L+RE  ++  I+V++   D          +     V + + + ND  P   
Sbjct: 2545 RGQIFTLEKLDRETPAEKVISVRLMAKDAGG-------KVAFCTVNVILTDDNDNAPQFR 2597

Query: 378  PPHLETQIYSTVESFHS-AQLFSKDSPQ---EHLSYSIVGEQDESRKKRLEKMSLS 429
                E  I S+     S  ++ + D+ +     ++Y+I  +  ES K+ LE   LS
Sbjct: 2598 ATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEAD-SESVKENLEINKLS 2652



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 53/243 (21%), Positives = 98/243 (40%), Gaps = 46/243 (18%)

Query: 142  INVTEKKSVGEIIARVKATDRDEDSS--IIYSFKTQ----QKMFCLDPFTGTITLLQPLN 195
            +N+    + G  + +V A+D DE S+  I Y+ +      ++   ++  +G IT      
Sbjct: 2603 VNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVIT------ 2656

Query: 196  LDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSR 255
                +   +  LE E            FT FV  VD+         +  +++ V V++  
Sbjct: 2657 ----TKESLIGLENE-----------FFTFFVRAVDN------GSPSKESVVLVYVKILP 2695

Query: 256  INELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNL---GTPPKF 312
                 P  S   +TF+V E+ P+ T +  +    +      + Y++V GN         F
Sbjct: 2696 PEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHS----GTVLYSLVKGNTPESNRDESF 2751

Query: 313  YIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDE 372
             I+  +G +KL  SL+ E    Y+ ++      +D       +   +  V+I V + ND 
Sbjct: 2752 VIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDD------HEMVASVDVSIQVKDANDN 2805

Query: 373  PPV 375
             PV
Sbjct: 2806 SPV 2808



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 28/95 (29%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 249 VIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGT 308
           V V+V   N+L P+ S ++++ S+ EN+ + T + +V+ TDAD   N   Y         
Sbjct: 135 VRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDR--- 191

Query: 309 PPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTD 343
              F I P +GVI L   L+      Y++ +   D
Sbjct: 192 TDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAAD 226



 Score = 37.4 bits (85), Expect = 0.032
 Identities = 50/214 (23%), Positives = 91/214 (42%), Gaps = 45/214 (21%)

Query: 166 SSIIYSFKTQ--QKMFCLDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTF 223
           S + Y FK+   +  F L+  TG I++L+P+     ++   + LE   +D   +T     
Sbjct: 396 SHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAH---FELEVTTSDRKASTK---- 448

Query: 224 TVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVG 283
                                    V+V+V   N   P  + +A+  +  EN P+ T V 
Sbjct: 449 -------------------------VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVM 483

Query: 284 KVTFTDADWPFNN-MEYTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQ-YKIAVKV 341
            ++  D D   N  + Y+I   NL   P F I+  TG +   ++L+ E+  + Y + ++ 
Sbjct: 484 SLSAVDPDEGENGYVTYSI--ANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRIRA 540

Query: 342 TDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
           +D     +P    +R      TI++ N+ND  P+
Sbjct: 541 SDW---GLP---YRREVEVLATITLNNLNDNTPL 568


>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
          Length = 3354

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 58/175 (33%), Positives = 85/175 (48%), Gaps = 12/175 (6%)

Query: 244  AAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDAD-WPFNNMEYTIV 302
            AA I V + +  IN+ NPI    ++  +VFE+ PV T++  VT TDAD   F  +EY++ 
Sbjct: 2383 AAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLG 2442

Query: 303  GGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQV 362
             G      KF I P TG I +L SL+RE +  Y +     D   D   +   +R  + QV
Sbjct: 2443 DGE----SKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASN---RRENSVQV 2495

Query: 363  TISVLNMNDEPPVCNPPHLETQIYSTVESFHSAQLF----SKDSPQEHLSYSIVG 413
             I VL++ND  P  + P   T +Y    +  S          + P   L+YS+ G
Sbjct: 2496 VIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEG 2550



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 66/264 (25%), Positives = 117/264 (44%), Gaps = 37/264 (14%)

Query: 141 SINVTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDN 198
           S+ + E   VG  I  V ATD D     S++YSF+   + F +D   G +T+++ L+ + 
Sbjct: 138 SVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYE- 196

Query: 199 PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
              ++ Y L   ATD              ++   P+S          +  + + ++ + +
Sbjct: 197 --TTQAYQLTVNATD--------------QDKTRPLS---------TLANLAIIITDVQD 231

Query: 259 LNPIGSASAFTFSVFENSPVDTLVGKVTFTDAD-WPFNNMEYTIVGGNLGTPPKFYIEPD 317
           ++PI     ++ +++E+SP  T V  +T  D D      + YTIV GN  T   F ++  
Sbjct: 232 MDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGN--TNSIFALDYI 289

Query: 318 TGVIKLLDSLNRE---IESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
           +GV+ L   L+RE       + + VK T+L++D  P      + T    I V+++ND  P
Sbjct: 290 SGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS---DATVTTTFNILVIDINDNAP 346

Query: 375 VCNPPHLETQIYSTVESFHSAQLF 398
             N       I    +   +  LF
Sbjct: 347 EFNSSEYSVAITELAQVGFALPLF 370



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 84/339 (24%), Positives = 135/339 (39%), Gaps = 52/339 (15%)

Query: 138 PLDSINVTEKKSVGEIIARVKATDRDEDS--SIIYSFKTQQKMFCLDPFTGTITLLQPLN 195
           PL +I++ E  +VG  +  V ATD D  +   + Y F      F LD  TG I L+  L+
Sbjct: 463 PLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLD 522

Query: 196 LDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSR 255
            +       ++L   A D G   ++    + V +V+D +                     
Sbjct: 523 YELIQR---FTLTIIARDGGGEETTGRVRINVLDVNDNV--------------------- 558

Query: 256 INELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN-MEYTIVGGN-LGTPPKFY 313
                P     A+  ++ EN P  T + ++  TD D P NN + Y+IV  +  G+     
Sbjct: 559 -----PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDIS 613

Query: 314 IEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
           +    GVI +   L+ E  S   I + V  +D    P      + T  VTI V + ND P
Sbjct: 614 LYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPP-----LNSTVPVTIEVFDENDNP 668

Query: 374 PVCNPPHLETQIY------STVESFHSAQL-FSKDSPQEHLSYSIVGEQD---ESRKKRL 423
           P  + P     +       +TV   ++  L  S++  QE + YS+ G       +R   +
Sbjct: 669 PTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEI 728

Query: 424 EKMSLSSYYFKKCFTDVIRADN----HNNDYFPSVTNIT 458
              SL     K  +  ++RA +    HN     +  NIT
Sbjct: 729 TTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNIT 767



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 72/299 (24%), Positives = 126/299 (42%), Gaps = 42/299 (14%)

Query: 112  RVTATDEVFANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYS 171
            + T++  VF N   LN   D   +  P  +  V E    G  I +V A D DE  + + S
Sbjct: 869  KATSSATVFVNLLDLN-DNDPTFQNLPFVA-EVLEGIPAGVSIYQVVAIDLDEGLNGLVS 926

Query: 172  FKTQQKM----FCLDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFV 227
            ++    M    F ++  +G +     L+ +  +    Y L   A+D G  T S T T+ +
Sbjct: 927  YRMPVGMPRMDFLINSSSGVVVTTTELDRERIAE---YQLRVVASDAGTPTKSSTSTLTI 983

Query: 228  ENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTF 287
              +D                        +N+  P    + +  SV E+ P +  V  +  
Sbjct: 984  HVLD------------------------VNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1019

Query: 288  TDADWPFN-NMEYTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDN 346
            TD D   N  + Y I GGN+    KF +     V++ +  L+RE  + Y + ++   +DN
Sbjct: 1020 TDNDVGLNAELSYFITGGNVDG--KFSVGYRDAVVRTVVGLDRETTAAYMLILEA--IDN 1075

Query: 347  DAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPHLETQIYSTVESFHS-AQLFSKDSPQ 404
              +    ++ +GTA V ++VL++ND  P+      E  +   +   HS  QL + D+ +
Sbjct: 1076 GPVG---KRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADE 1131



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 83/318 (26%), Positives = 125/318 (39%), Gaps = 62/318 (19%)

Query: 60   LIVDTG--RLYRHVLTINIIDVPESPNCTADPKFSSGTA--TLEIDE-----------DY 104
            +++D G   L   ++TI  +D+ E PN T      +G    T  ID            DY
Sbjct: 1641 VLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDY 1700

Query: 105  PLFQSIYR--VTATDEVFANGDRL--------NVGGDHCARP-FPLD---SINVTEKKSV 150
             +    Y   VTATD+      RL        NV   +   P FP D      VTE +  
Sbjct: 1701 EISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP- 1759

Query: 151  GEIIARVKATDRDE--DSSIIYSFKTQQKM--FCLDPFTGTITLLQPLNLDNPSNSKIYS 206
            G  +    A DRD   +  + YS      +  F + P  G + + + + LD  + +  Y+
Sbjct: 1760 GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIA-FYN 1818

Query: 207  LETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSAS 266
            L   A D G    S T  V +                        RV  IN+ +P+    
Sbjct: 1819 LTICARDRGMPPLSSTMLVGI------------------------RVLDINDNDPVLLNL 1854

Query: 267  AFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIEPDTGVIKLLD 325
                ++ ENSPV + V  V  +DAD   N  + + I  GN      F+I   TG++ +  
Sbjct: 1855 PMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGN--RERAFFINATTGIVTVNR 1912

Query: 326  SLNREIESQYKIAVKVTD 343
             L+RE   +YK+ + V D
Sbjct: 1913 PLDRERIPEYKLTISVKD 1930



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 94/366 (25%), Positives = 149/366 (40%), Gaps = 80/366 (21%)

Query: 62   VDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVFA 121
            +D  R+  + LTI++ D PE+P               + ++++PLF    + T   EV  
Sbjct: 1914 LDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFT---KSTYQAEVME 1970

Query: 122  NGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFK---TQQKM 178
            N               PL  +N       G I+A     D D+D   + +++    Q  +
Sbjct: 1971 NSPAGT----------PLTVLN-------GPILA----LDADQDIYAVVTYQLLGAQSGL 2009

Query: 179  FCLDPFTGTITLLQPLNLDNPSNSK-IYSLETEATDNG--NNTSSYTFTVFVENVDDPIS 235
            F ++  TG +T+   + +D  + S  I  L   A D G  N+T+    T+    +DD   
Sbjct: 2010 FDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITI----LDD--- 2062

Query: 236  CDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN 295
                                 N+  P  S +  T  + EN P    V +VT TD D   N
Sbjct: 2063 ---------------------NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLN 2101

Query: 296  -NMEYTIVGGNLGTPPKFYIEPDTGVIKLLD-SLNREIESQYKIAVKVTDLDNDAIPDPL 353
              + Y I     G   +F I   TGVI++ + +++RE +  Y++ V  T  D   +P   
Sbjct: 2102 GELVYRI---EAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVAT--DRGTVP--- 2153

Query: 354  RQRSGTAQVTISVLNMND-EPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEH-----L 407
               SGTA VTI + ++ND  P   NP     Q  S +ES     + +  +  +H     L
Sbjct: 2154 --LSGTAIVTILIDDINDSRPEFLNP----IQTVSVLESAEPGTVIANITAIDHDLNPKL 2207

Query: 408  SYSIVG 413
             Y IVG
Sbjct: 2208 EYHIVG 2213



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 100/373 (26%), Positives = 153/373 (41%), Gaps = 103/373 (27%)

Query: 28   GAGLGPNQIMAGSGVITATK--IFNYE--TDPIRFLLIV--DTGRLYRHV-LTINIIDVP 80
            GA  G   I + +GV+T     I + E  + PI  LL++  D G L     L I I+D  
Sbjct: 2004 GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDN 2063

Query: 81   ESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVFANGDRLNVGGDHCARPFPLD 140
            ++      P FS  T T+ + E+ P   S+ +VTATDE       LN             
Sbjct: 2064 DNR-----PTFSPATLTVHLLENCPPGFSVLQVTATDE----DSGLN------------- 2101

Query: 141  SINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPS 200
                      GE++ R++A  +D               F +   TG I  +    +D   
Sbjct: 2102 ----------GELVYRIEAGAQDR--------------FLIHLVTGVIR-VGNATIDR-E 2135

Query: 201  NSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVI---VRVSRIN 257
              + Y L   ATD G        TV       P+S       G AI+T++   +  SR  
Sbjct: 2136 EQESYRLTVVATDRG--------TV-------PLS-------GTAIVTILIDDINDSRPE 2173

Query: 258  ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNL---------GT 308
             LNPI      T SV E++   T++  +T  D D     +EY IVG              
Sbjct: 2174 FLNPIQ-----TVSVLESAEPGTVIANITAIDHDLN-PKLEYHIVGIVAKDDTDRLVPNQ 2227

Query: 309  PPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRS---GTAQVTIS 365
               F +  +TG + +   +NRE+ + Y++ + V D  +D     L +RS     A++T++
Sbjct: 2228 EDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASD-----LPERSVSVPNAKLTVN 2282

Query: 366  VLNMNDEPPVCNP 378
            VL++ND  P   P
Sbjct: 2283 VLDVNDNTPQFKP 2295



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 73/254 (28%), Positives = 116/254 (45%), Gaps = 50/254 (19%)

Query: 142  INVTEKKSVGEIIARVKATDRDE--DSSIIYSF-----KTQQKMFCLDPFTGTITLLQPL 194
            +++ E+  +   +  V ATD+DE  + ++ YSF         + F +DP +G I   Q L
Sbjct: 2620 LHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRL 2679

Query: 195  NLDNPSNSKIYSLETEATDNGNNTSSYTFT---VFVENVDDPISCDPSFSTGAAIITVIV 251
            + ++ +   +YSL   A+D G      T     V +E++DD    +P F          V
Sbjct: 2680 DRESQA---VYSLILVASDLGQPVPYETMQPLQVALEDIDDN---EPLF----------V 2723

Query: 252  RVSRINELNPIGSASAFTFSVFENSPVDTLVGKVT-FTDAD-WPFNNMEYTIVGGNLGTP 309
            R        P GS      +V E+SP  TLVG VT   DAD  P   + Y I  GN    
Sbjct: 2724 RP-------PKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGN--EE 2774

Query: 310  PKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGT---------A 360
              F+++PD G + +L  L+RE E+ +   VK +   ++    P R  S T          
Sbjct: 2775 KNFHLQPD-GCLLVLRDLDREREAIFSFIVKAS---SNRSWTPPRGPSPTLDLVADLTLQ 2830

Query: 361  QVTISVLNMNDEPP 374
            +V + + ++ND+PP
Sbjct: 2831 EVRVVLEDINDQPP 2844



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 70/280 (25%), Positives = 108/280 (38%), Gaps = 36/280 (12%)

Query: 142  INVTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNP 199
            IN+ E       +  V A D D  E+ +++YS +   K + L+  TG I     +     
Sbjct: 785  INLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAM----- 839

Query: 200  SNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINEL 259
                   L+ E  D           V V +   P    P  +T +A  TV V +  +N+ 
Sbjct: 840  -------LDRENPDPHEAELMRKIVVSVTDCGRP----PLKATSSA--TVFVNLLDLNDN 886

Query: 260  NPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNM-EYTIVGGNLGTPPK-FYIEPD 317
            +P      F   V E  P    + +V   D D   N +  Y +    +G P   F I   
Sbjct: 887  DPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP---VGMPRMDFLINSS 943

Query: 318  TGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCN 377
            +GV+     L+RE  ++Y++ V  +D            +S T+ +TI VL++NDE P   
Sbjct: 944  SGVVVTTTELDRERIAEYQLRVVASDAGTPT-------KSSTSTLTIHVLDVNDETPTFF 996

Query: 378  PPHLETQIYSTV-ESFHSAQLFSKDSP---QEHLSYSIVG 413
            P      +   V   F    L   D+       LSY I G
Sbjct: 997  PAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1036



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 56/249 (22%), Positives = 98/249 (39%), Gaps = 50/249 (20%)

Query: 144 VTEKKSVGEIIARVKATDRDEDSSII-YSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNS 202
           ++E   VG  + ++ A D D D  +   S +   + F ++P TG + L QPL+ +  S  
Sbjct: 42  ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSE- 100

Query: 203 KIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPI 262
             +++E   +D+                            G     V ++V  +N+  P 
Sbjct: 101 --FTVEFSVSDH---------------------------QGVITRKVNIQVGDVNDNAPT 131

Query: 263 GSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNL---GTPPK--FYIEPD 317
                ++  + EN+PV T +  V  TD D           GG++     PP   F I+  
Sbjct: 132 FHNQPYSVRIPENTPVGTPIFIVNATDPDLG--------AGGSVLYSFQPPSQFFAIDSA 183

Query: 318 TGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCN 377
            G++ ++  L+ E    Y++ V  TD       D  R  S  A + I + ++ D  P+  
Sbjct: 184 RGIVTVIRELDYETTQAYQLTVNATD------QDKTRPLSTLANLAIIITDVQDMDPIFI 237

Query: 378 PPHLETQIY 386
                T IY
Sbjct: 238 NLPYSTNIY 246



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 66/250 (26%), Positives = 102/250 (40%), Gaps = 48/250 (19%)

Query: 138 PLDSINVTEKKSVGEIIARVKATDRDED-----SSIIYSFKTQQKMFCLDPFTGTITLLQ 192
           P   ++V E    G  +  + ATD D        SIIYS +   + F ++  +G IT   
Sbjct: 674 PAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-FRINARSGEITTTS 732

Query: 193 PLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVR 252
            L+ +  S    Y L   A D G   +  T                       I TV + 
Sbjct: 733 LLDRETKSE---YILIVRAVDGGVGHNQKT----------------------GIATVNIT 767

Query: 253 VSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKF 312
           +  IN+ +P    + +  ++ E +P D+ V  V   D D   N    T+V  ++  P KF
Sbjct: 768 LLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG---TLV-YSIQPPNKF 823

Query: 313 Y-IEPDTGVIK----LLDSLN---REIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTI 364
           Y +   TG I+    +LD  N    E E   KI V VTD        P  + + +A V +
Sbjct: 824 YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGR-----PPLKATSSATVFV 878

Query: 365 SVLNMNDEPP 374
           ++L++ND  P
Sbjct: 879 NLLDLNDNDP 888



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 56/254 (22%), Positives = 104/254 (40%), Gaps = 41/254 (16%)

Query: 141  SINVTEKKSVGEIIARVKATDRDEDSSIIYSFK----TQQKMFCLDPFTGTITLLQPLNL 196
            +I ++E   V   +A V A+D D   +   +F      +++ F ++  TG +T+ +PL+ 
Sbjct: 1857 NITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDR 1916

Query: 197  DNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRI 256
            +       Y L     DN  N         +   D  +              +++ +S  
Sbjct: 1917 ERIPE---YKLTISVKDNPENPR-------IARRDYDL--------------LLIFLSDE 1952

Query: 257  NELNPIGSASAFTFSVFENSPVDT----LVGKVTFTDADWP-FNNMEYTIVGGNLGTPPK 311
            N+ +P+ + S +   V ENSP  T    L G +   DAD   +  + Y ++G   G    
Sbjct: 1953 NDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGL--- 2009

Query: 312  FYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMND 371
            F I   TGV+ +   +  + E     A     L+   + + +   + TA + I++L+ ND
Sbjct: 2010 FDINSSTGVVTVRSGVIIDRE-----AFSPPILELLLLAEDIGLLNSTAHLLITILDDND 2064

Query: 372  EPPVCNPPHLETQI 385
              P  +P  L   +
Sbjct: 2065 NRPTFSPATLTVHL 2078



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 37/127 (29%), Positives = 61/127 (48%), Gaps = 16/127 (12%)

Query: 251 VRVSRINELN--PIGSASAFTFSVFENSPVDTLVGKVTFTDAD-WPFNNMEYTIVGGNLG 307
           V+++ INE +  PI S   +  S++EN  V T V  V  TD D   F  + Y        
Sbjct: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF----SD 501

Query: 308 TPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVL 367
            P +F ++ DTG+I L+  L+ E+  ++ + +   D   +           T +V I+VL
Sbjct: 502 DPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---------ETTGRVRINVL 552

Query: 368 NMNDEPP 374
           ++ND  P
Sbjct: 553 DVNDNVP 559



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 77/335 (22%), Positives = 132/335 (39%), Gaps = 62/335 (18%)

Query: 95   TATLEIDEDYPLFQSIYRV--TATDEVFANGDRLNVGGDHCARPFPLDSINVTEKKSVGE 152
            T T+  D+  P   S  +V  T  DE   N  R +   D         ++++ E   VG+
Sbjct: 1386 TLTVVADDGGPKVDSTVKVYITVLDEN-DNSPRFDFTSD--------SAVSIPEDCPVGQ 1436

Query: 153  IIARVKATDRDEDSS--IIYSFKTQQKMFCLDPFT-----GTITLLQPLNLDNPSNSKIY 205
             +A VKA D D  S+  +++S  +       +  T     G + + +PL+ +   +   Y
Sbjct: 1437 RVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDH---Y 1493

Query: 206  SLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNP-IGS 264
             L+  A+D G         + V  +D                        IN+  P I S
Sbjct: 1494 ILQVVASDRGTPPRKKDHILQVTILD------------------------INDNPPVIES 1529

Query: 265  ASAFTFSVFENSPVDTLVGKVTFTDADWPFNN-MEYTIVGGNLGTPPKFYIEPDTGVIKL 323
               +  SV EN    T V +V  TD D   N+ + Y I  GN      F ++  +G I  
Sbjct: 1530 PFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMA--FRMDRISGEIAT 1587

Query: 324  LDSL-NREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPHLE 382
              +  +RE +S Y +   V D     +       S T  V +++++ ND  P+   PH E
Sbjct: 1588 RPAPPDRERQSFYHLVATVEDEGTPTL-------SATTHVYVTIVDENDNAPMFQQPHYE 1640

Query: 383  TQIYSTVESFHSA-----QLFSKDSPQEHLSYSIV 412
              +    ++ +++      L   + P   ++Y+IV
Sbjct: 1641 VLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIV 1675



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 62/255 (24%), Positives = 103/255 (40%), Gaps = 53/255 (20%)

Query: 138  PLDSINVTEKKSVGEIIARVKATDRDE--DSSIIYSFKTQQ-KMFCLDPFTGTITLLQPL 194
            P  S +V E +  G  +  + ATD+DE  +  + YS +    + F +D  +G +T  +PL
Sbjct: 2512 PQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL 2571

Query: 195  NLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVD----DPISCDPSFSTGAAIITVI 250
                  + + +SL   ATD G      T  + VE +D     P+   P   T        
Sbjct: 2572 Q-----SYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGT-------- 2618

Query: 251  VRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFT------DADWPFNNMEYTIVGG 304
              +  I E  P+ S     + V+     + L G V ++      + DW F          
Sbjct: 2619 --ILHIREEIPLRSN---VYEVYATDKDEGLNGAVRYSFLKTAGNRDWEF---------- 2663

Query: 305  NLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTI 364
                   F I+P +G+I+    L+RE ++ Y + +  +DL    +P    Q     QV +
Sbjct: 2664 -------FIIDPISGLIQTAQRLDRESQAVYSLILVASDL-GQPVPYETMQ---PLQVAL 2712

Query: 365  SVLNMNDEPPVCNPP 379
              ++ N EP    PP
Sbjct: 2713 EDIDDN-EPLFVRPP 2726



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 88/379 (23%), Positives = 147/379 (38%), Gaps = 76/379 (20%)

Query: 70   HVLTINIIDVPESP---------NCTADPKFSSGTATLEI---DEDYPL--FQSIYRVTA 115
            H+L + I+D+ ++P         N + +     GTA +++   D D  +    S Y    
Sbjct: 1511 HILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEG 1570

Query: 116  TDEVFANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKT- 174
              ++    DR  + G+   RP P D     E++S   ++A V+       S+  + + T 
Sbjct: 1571 NKDMAFRMDR--ISGEIATRPAPPD----RERQSFYHLVATVEDEGTPTLSATTHVYVTI 1624

Query: 175  ----------QQKMFCL------DPFTGTITLLQPLNLD-NPSNSKIYSLE--------- 208
                      QQ  + +      D    ++  +Q L+LD  P+ +  Y++          
Sbjct: 1625 VDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFR 1684

Query: 209  --------TEATDNGNNTSSYTFTVFVENVDD-PISCDPSFSTGAAIITVIVRVSRINEL 259
                    T A +     S   +T+ V   D  PI      ST     TV+V V+ IN+ 
Sbjct: 1685 IDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTST----TTVLVNVNDINDN 1740

Query: 260  NPIGSAS-AFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGN-LGTPPKFYIEPD 317
             P         F V E  P   +   +       P   +EY+I+ G+ LG   +F I P 
Sbjct: 1741 VPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLG---EFVISPV 1797

Query: 318  TGVIKLLD--SLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
             GV+++     L+RE  + Y + +   D     +       S T  V I VL++ND  PV
Sbjct: 1798 EGVLRVRKDVELDRETIAFYNLTICARDRGMPPL-------SSTMLVGIRVLDINDNDPV 1850

Query: 376  C--NPPHLETQIYSTVESF 392
                P ++     S V SF
Sbjct: 1851 LLNLPMNITISENSPVSSF 1869



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 50/269 (18%), Positives = 100/269 (37%), Gaps = 47/269 (17%)

Query: 138  PLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSF-------------KTQQKMFCLDPF 184
            P+ +++V E    G +IA + A D D +  + Y                 Q+  F ++  
Sbjct: 2177 PIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNIN 2236

Query: 185  TGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGA 244
            TG++ +  P+N +  +    Y +     DN ++                    P  S   
Sbjct: 2237 TGSVMVKSPMNRELVAT---YEVTLSVIDNASDL-------------------PERSVSV 2274

Query: 245  AIITVIVRVSRINELNPIGSASAFTF---SVFENSPVDTLVGKVTFTDADWPFNNM-EYT 300
                + V V  +N+  P       T+    + E +   T +  V   D D   N +  YT
Sbjct: 2275 PNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYT 2334

Query: 301  IVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTA 360
            ++      PP +    D+   K++ +   + E  + +   V   DN + P     R+   
Sbjct: 2335 LLD---LVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPP-----RAAEI 2386

Query: 361  QVTISVLNMNDEPPVCNPPHLETQIYSTV 389
             V + ++++ND  P+ + P  +  ++  V
Sbjct: 2387 PVYLEIVDINDNNPIFDQPSYQEAVFEDV 2415



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 12/128 (9%)

Query: 247  ITVIVRVSRINELNPIGSASAFT-FSVFENSPVDTLVGKVTFTDADWPFNNM-EYTIVGG 304
            + VIV V  IN+  P+ +   ++   + E + + T V  V  TD D     +  Y I+ G
Sbjct: 1192 VRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG 1251

Query: 305  NLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTI 364
              G   KF I+  TG+I  ++ L+ E ++ Y + V  TD        P  Q  G   V I
Sbjct: 1252 AEG---KFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ-----APPFNQ--GFCSVYI 1301

Query: 365  SVLNMNDE 372
            ++LN  DE
Sbjct: 1302 TLLNELDE 1309



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 35/118 (29%), Positives = 53/118 (44%), Gaps = 23/118 (19%)

Query: 272 VFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPK--FYIEPDTGVIKLLDSLNR 329
           + E++PV + V ++   D D         +V G  G      F +EPDTGV+ L   L+R
Sbjct: 42  ISEDTPVGSSVTQLLAQDMD------NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDR 95

Query: 330 EIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPHLETQIYS 387
           E +S++ +   V+D           Q   T +V I V ++ND     N P    Q YS
Sbjct: 96  ETKSEFTVEFSVSD----------HQGVITRKVNIQVGDVND-----NAPTFHNQPYS 138



 Score = 36.6 bits (83), Expect = 0.055
 Identities = 54/238 (22%), Positives = 96/238 (40%), Gaps = 42/238 (17%)

Query: 142  INVTEKKSVGEIIARVKATDRDEDSSIIYSFKT---QQKMFCLDPFTGTITLLQPLNLDN 198
            + + E   +G  +  V+ATDRD     + +++     +  F +D  TG I  +  L+ + 
Sbjct: 1216 LGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYET 1275

Query: 199  PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
             ++   Y +   ATD                        P F+ G   +  I  ++ ++E
Sbjct: 1276 KTS---YMMNVSATDQA----------------------PPFNQGFCSV-YITLLNELDE 1309

Query: 259  LNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPK--FYIEP 316
                 +AS +  ++ EN  + T + +V     D   N + Y        T  K  F I+ 
Sbjct: 1310 AVQFSNAS-YEAAILENLALGTEIVRVQAYSID-NLNQITYRF-NAYTSTQAKALFKIDA 1366

Query: 317  DTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
             TGVI +   ++RE    Y + V    + +D  P    +   T +V I+VL+ ND  P
Sbjct: 1367 ITGVITVQGLVDREKGDFYTLTV----VADDGGP----KVDSTVKVYITVLDENDNSP 1416


>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
            sapiens]
          Length = 3312

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 90/332 (27%), Positives = 143/332 (43%), Gaps = 50/332 (15%)

Query: 141  SINVTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDN 198
            S++V E + +G  I  + A+D D  E++ I Y  +     F +D  +G ITL  PL+ + 
Sbjct: 864  SVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYE- 922

Query: 199  PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
              +   Y+L   A DNG                 P   D ++        V V V+ +N+
Sbjct: 923  --DQVTYTLAITARDNG----------------IPQKADTTY--------VEVMVNDVND 956

Query: 259  LNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIEPD 317
              P   AS +T  V E++P  T V +++ TD D   N  ++YT   G  G    F IEP 
Sbjct: 957  NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDG-DGDFTIEPT 1015

Query: 318  TGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCN 377
            +G+++ +  L+RE  S Y++     D     +P PLR       + + V ++ND  PV  
Sbjct: 1016 SGIVRTVRRLDREAVSVYELTAYAVD---RGVP-PLRT---PVSIQVMVQDVNDNAPVFP 1068

Query: 378  PPHLETQI-YSTVESFHSAQLFSKD---SPQEHLSYSIVGEQDESRKKRLEKMSLSSYYF 433
                E ++  +++     AQ+ + D    P  H+ Y IV    E     L +M +    F
Sbjct: 1069 AEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIV----EGNIPELFQMDI----F 1120

Query: 434  KKCFTDVIRADNHNNDYFPSVTNITRANQVSR 465
                T +I  D      +  V   T A  VSR
Sbjct: 1121 SGELTALIDLDYEARQEYVIVVQATSAPLVSR 1152



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 77/275 (28%), Positives = 120/275 (43%), Gaps = 44/275 (16%)

Query: 153 IIARVKATDRDEDSSIIYSFK----TQQKMFCLDPFTGTITLLQPLNLDNPSNSKIYSLE 208
           ++ RV ATDRD+D++ +  +       +  F +D  TG I ++ PL+ +     + Y+L 
Sbjct: 563 VVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA---EREYALR 619

Query: 209 TEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAF 268
             A D G                 P+S +    TG A I V+     IN+  PI  ++ F
Sbjct: 620 IRAQDAGR---------------PPLSNN----TGLASIQVV----DINDHIPIFVSTPF 656

Query: 269 TFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIEPDTGVIKLLDSL 327
             SV EN+P+   V  +   DAD   N  +EY++ G    TP  F I   TG + +   L
Sbjct: 657 QVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP--FVINSATGWVSVSGPL 714

Query: 328 NREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP--VCNPPHLETQI 385
           +RE    Y   V+  D  +  +       S +A VT++VL++ND  P       HL    
Sbjct: 715 DRESVEHYFFGVEARDHGSPPL-------SASASVTVTVLDVNDNRPEFTMKEYHLRLNE 767

Query: 386 YSTV-ESFHSAQLFSKDSPQEHLSYSIVGEQDESR 419
            + V  S  S     +D+    +SY I G    +R
Sbjct: 768 DAAVGTSVVSVTAVDRDA-NSAISYQITGGNTRNR 801



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 61/230 (26%), Positives = 103/230 (44%), Gaps = 45/230 (19%)

Query: 154  IARVKATDRDEDSS--IIYSFKTQQKM---FCLDPFTGTITLLQPLNLDNPSNSKIYSLE 208
            + ++ ATDRD  ++  + Y+F+  +     F ++P +G +  ++ L+ +  S   +Y L 
Sbjct: 980  VLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVS---VYELT 1036

Query: 209  TEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAF 268
              A D G           V  +  P+S             + V V  +N+  P+  A  F
Sbjct: 1037 AYAVDRG-----------VPPLRTPVS-------------IQVMVQDVNDNAPVFPAEEF 1072

Query: 269  TFSVFENSPVDTLVGKVTFTDAD-WPFNNMEYTIVGGNLGTPPKFYIEPDTGVIKLLDSL 327
               V ENS V ++V ++T  D D  P  ++ Y IV GN+  P  F ++  +G +  L  L
Sbjct: 1073 EVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI--PELFQMDIFSGELTALIDL 1130

Query: 328  NREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCN 377
            + E   +Y I V+ T         PL  R   A V + +++ ND  PV N
Sbjct: 1131 DYEARQEYVIVVQATSA-------PLVSR---ATVHVRLVDQNDNSPVLN 1170



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 65/257 (25%), Positives = 104/257 (40%), Gaps = 43/257 (16%)

Query: 144 VTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQ-----KMFCLDPFTGTITLLQPLNL 196
           V E ++ G  + RV A D D  E   ++YS          ++F +DP +G I     L  
Sbjct: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAAL-- 391

Query: 197 DNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRI 256
           D  S  + Y L   A D+G+   S T                          V V V+  
Sbjct: 392 DRESMERHY-LRVTAQDHGSPRLSAT------------------------TMVAVTVADR 426

Query: 257 NELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVG---GNLGTPPKF 312
           N+ +P+   + +  ++ EN      + ++  TD D P N N+ Y  VG           F
Sbjct: 427 NDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAF 486

Query: 313 YIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDE 372
            I+P +G+I     ++RE    Y++ V+ +D   +  P     RS T +V I+VL+ ND 
Sbjct: 487 EIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGP-----RSATVRVHITVLDENDN 541

Query: 373 PPVCNPPHLETQIYSTV 389
            P  +      Q+   V
Sbjct: 542 APQFSEKRYVAQVREDV 558



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 59/269 (21%), Positives = 104/269 (38%), Gaps = 44/269 (16%)

Query: 142 INVTEKKSVGEIIARVKATDRDEDSSIIYSFK--TQQKMFCLDPF--TGTITLLQPLNLD 197
           + + E  +VG  +  V A DRD +S+I Y       +  F +      G +TL  PL+  
Sbjct: 763 LRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDY- 821

Query: 198 NPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRIN 257
                + + L   A+D   +   Y                           V + ++  N
Sbjct: 822 --KQERYFKLVLTASDRALHDHCY---------------------------VHINITDAN 852

Query: 258 ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPD 317
              P+  ++ ++ SV E+ P+ + +  ++ +D D   N     ++  NL   P+F I+ D
Sbjct: 853 THRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNL---PQFRIDAD 909

Query: 318 TGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCN 377
           +G I L   L+ E +  Y +A+   D   + IP    Q++ T  V + V ++ND  P   
Sbjct: 910 SGAITLQAPLDYEDQVTYTLAITARD---NGIP----QKADTTYVEVMVNDVNDNAPQFV 962

Query: 378 PPHLETQIYSTVESFHSAQLFSKDSPQEH 406
             H    +      F S    S      H
Sbjct: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAH 991



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 71/282 (25%), Positives = 116/282 (41%), Gaps = 47/282 (16%)

Query: 146 EKKSVGEIIARVKATDRDE--DSSIIYSF-------KTQQKMFCLDPFTGTITLLQPLNL 196
           E    G  I +++ATD D   ++++ Y F             F +DP +G I+    ++ 
Sbjct: 444 ENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDR 503

Query: 197 DNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRI 256
           ++  +   Y L  EA+D G      + TV V                   ITV+      
Sbjct: 504 EHMES---YELVVEASDQGQEPGPRSATVRVH------------------ITVLDE---- 538

Query: 257 NELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNM-EYTIVGGNLGTPPKFYIE 315
           N+  P  S   +   V E+    T+V +VT TD D   N +  Y I+ GN  +   F I+
Sbjct: 539 NDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGN--SRGHFAID 596

Query: 316 PDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
             TG I+++  L+ E E +Y + ++      DA   PL   +G A  +I V+++ND  P+
Sbjct: 597 SLTGEIQVVAPLDFEAEREYALRIRA----QDAGRPPLSNNTGLA--SIQVVDINDHIPI 650

Query: 376 CNPPHLETQIYSTVESFHSA---QLFSKDSPQE-HLSYSIVG 413
                 +  +       HS    Q    D  +   L YS+ G
Sbjct: 651 FVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTG 692


>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
           sapiens]
          Length = 2923

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 79/291 (27%), Positives = 130/291 (44%), Gaps = 44/291 (15%)

Query: 94  GTATLEIDEDYPLF-QSIYRVTATDEVFANGDRL--NVGGDHCARPFPLDS---INVTEK 147
           G  +L +  DY L  Q +  VTA+D    +  ++  NV   +  RP    S   +NV E 
Sbjct: 665 GLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNED 724

Query: 148 KSVGEIIARVKATDRD--EDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNSKIY 205
           +  G  +  + ATD D  E++ I Y  +     F +D  TG +T    L+ ++  +   Y
Sbjct: 725 RPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS---Y 781

Query: 206 SLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSA 265
           +L   A DNG    S T   ++E                      + V+ +N+  P    
Sbjct: 782 TLAITARDNGIPQKSDT--TYLE----------------------ILVNDVNDNAPQFLR 817

Query: 266 SAFTFSVFENSPVDTLVGKVTFTDADWPFNN-MEYTIVGGNLGTPPKFYIEPDTGVIKLL 324
            ++  SV+E+ P  T V +++ TD D   N  + YT  GG+ G    F +E  +G+++ L
Sbjct: 818 DSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGD-FIVESTSGIVRTL 876

Query: 325 DSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
             L+RE  +QY +     D        P+       +VT++VL++ND PPV
Sbjct: 877 RRLDRENVAQYVLRAYAVDKGMPPARTPM-------EVTVTVLDVNDNPPV 920



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 67/249 (26%), Positives = 109/249 (43%), Gaps = 40/249 (16%)

Query: 142 INVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQ----QKMFCLDPFTGTITLLQPLNLD 197
           + V E  + G  + RV A+DRD+ S+ +  +       +  F LD  TG + ++ PL+ +
Sbjct: 406 VQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYE 465

Query: 198 NPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRIN 257
               +K Y+L   A D G                      P  S  + ++TV  +V  IN
Sbjct: 466 T---TKEYTLRVRAQDGGR---------------------PPLSNVSGLVTV--QVLDIN 499

Query: 258 ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIEP 316
           +  PI  ++ F  +V E+ P+  LV  V   DAD   N  +EY + G  +G    F I  
Sbjct: 500 DNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG--VGHDFPFTINN 557

Query: 317 DTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVC 376
            TG I +   L+RE    Y   V+  D    A+       + +A V+++VL++ND  P  
Sbjct: 558 GTGWISVAAELDREEVDFYSFGVEARDHGTPAL-------TASASVSVTVLDVNDNNPTF 610

Query: 377 NPPHLETQI 385
             P    ++
Sbjct: 611 TQPEYTVRL 619



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 69/262 (26%), Positives = 112/262 (42%), Gaps = 43/262 (16%)

Query: 138 PLDSINVTEKKSVGEIIARVKATDRDEDSS--------IIYSFKTQQKMFCLDPFTGTIT 189
           P     V E +  G  +A ++A D DE  +         ++  ++ Q  F LDP TG +T
Sbjct: 184 PSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQ-FFSLDPVTGAVT 242

Query: 190 LLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITV 249
             + L+ +  S    +     A D+G    S                        A+ T+
Sbjct: 243 TAEELDRETKST---HVFRVTAQDHGMPRRS------------------------ALATL 275

Query: 250 IVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGT 308
            + V+  N+ +P+     +  S+ EN  V   V  V  TD D P N N+ Y ++ G+ G+
Sbjct: 276 TILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGS 335

Query: 309 PPK-FYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVL 367
           P + F I+P +GVI+    ++RE    Y++ V+ +D   D  P     RS TA V +SV 
Sbjct: 336 PSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP-----RSTTAAVFLSVE 390

Query: 368 NMNDEPPVCNPPHLETQIYSTV 389
           + ND  P  +      Q+   V
Sbjct: 391 DDNDNAPQFSEKRYVVQVREDV 412



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 88/379 (23%), Positives = 152/379 (40%), Gaps = 59/379 (15%)

Query: 38   AGSGVITATKIFNYETDPIRFLLIV--DTGRLYRHVLTINIIDVPESPNCTADPKFSSGT 95
            +G G+++     +Y+ +    L +   D  R     + +N+ D       T  P F S  
Sbjct: 662  SGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDAN-----THRPVFQSSH 716

Query: 96   ATLEIDEDYPLFQSIYRVTATDEVFANGDRLNVGGDHCARPFPLDSIN--VTEKKSVG-- 151
             T+ ++ED P   ++  ++ATDE      R+    +     F +D+    VT +  +   
Sbjct: 717  YTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYE 776

Query: 152  -------EIIARVKATDRDEDSS----IIYSFKTQQKMFCLDPFTGTI--------TLLQ 192
                    I AR     +  D++    ++         F  D + G++        ++LQ
Sbjct: 777  DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQ 836

Query: 193  PLNLDNPS--NSKIYSLETEATDNGN------NTSSYTFTVFV---ENVDDPI----SCD 237
                D  S  N +++    +  D+G+      +TS    T+     ENV   +    + D
Sbjct: 837  ISATDRDSGLNGRVF-YTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVD 895

Query: 238  PSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-N 296
                     + V V V  +N+  P+     F   V ENSP+   V +VT TD D   N  
Sbjct: 896  KGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQ 955

Query: 297  MEYTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQR 356
            + Y IV GN+  P  F ++  +G +  L  L+ E   +Y + ++ T         PL  R
Sbjct: 956  IMYQIVEGNI--PEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA-------PLVSR 1006

Query: 357  SGTAQVTISVLNMNDEPPV 375
               A V + +L+ ND PPV
Sbjct: 1007 ---ATVHVRLLDRNDNPPV 1022



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 62/261 (23%), Positives = 104/261 (39%), Gaps = 44/261 (16%)

Query: 138 PLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKT--QQKMFCLDPFT--GTITLLQP 193
           P  ++ + E  +VG  +  V A DRD  S I Y   +   +  F +   +  G ++L  P
Sbjct: 613 PEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALP 672

Query: 194 LNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRV 253
           L+         Y LE +                       ++   S  T      ++V V
Sbjct: 673 LD---------YKLERQYV---------------------LAVTASDGTRQDTAQIVVNV 702

Query: 254 SRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFY 313
           +  N   P+  +S +T +V E+ P  T V  ++ TD D   N      +  ++   P+F 
Sbjct: 703 TDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSI---PQFR 759

Query: 314 IEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
           I+ DTG +     L+ E +  Y +A+   D   + IP    Q+S T  + I V ++ND  
Sbjct: 760 IDADTGAVTTQAELDYEDQVSYTLAITARD---NGIP----QKSDTTYLEILVNDVNDNA 812

Query: 374 PVCNPPHLETQIYSTVESFHS 394
           P       +  +Y  V  F S
Sbjct: 813 PQFLRDSYQGSVYEDVPPFTS 833



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 56/246 (22%), Positives = 96/246 (39%), Gaps = 42/246 (17%)

Query: 144 VTEKKSVGEIIARVKATDRDEDSSIIYSFKT----QQKMFCLDPFTGTITLLQPLNLDNP 199
           V E   +G ++  V+A D D   +    ++         F ++  TG I++   L+ +  
Sbjct: 514 VLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEV 573

Query: 200 SNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINEL 259
                YS   EA D+G                      P+ +  A+   V V V  +N+ 
Sbjct: 574 D---FYSFGVEARDHGT---------------------PALTASAS---VSVTVLDVNDN 606

Query: 260 NPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTG 319
           NP  +   +T  + E++ V T V  V+  D D   + + Y I  GN         +   G
Sbjct: 607 NPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD-AHSVITYQITSGNTRNRFSITSQSGGG 665

Query: 320 VIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPP 379
           ++ L   L+ ++E QY +AV  +D            R  TAQ+ ++V + N   PV    
Sbjct: 666 LVSLALPLDYKLERQYVLAVTASD----------GTRQDTAQIVVNVTDANTHRPVFQSS 715

Query: 380 HLETQI 385
           H    +
Sbjct: 716 HYTVNV 721



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 26/126 (20%), Positives = 52/126 (41%), Gaps = 29/126 (23%)

Query: 72   LTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATD-------------- 117
            +T+ ++DV ++P     P F      + ++E+ P+  ++ RVTATD              
Sbjct: 907  VTVTVLDVNDNP-----PVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIV 961

Query: 118  ----------EVFANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSS 167
                      ++F+      V  D+  RP  +  I  T    V      V+  DR+++  
Sbjct: 962  EGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNPP 1021

Query: 168  IIYSFK 173
            ++ +F+
Sbjct: 1022 VLGNFE 1027


>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
          Length = 4557

 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 79/279 (28%), Positives = 121/279 (43%), Gaps = 49/279 (17%)

Query: 108  QSIY--RVTATDEVFANGDRLNVGGDHCARPFPL-DSINVT----EKKSVGEIIARVKAT 160
            Q IY   +TATD +F     + V         P+ D +  T    E     +II +V A 
Sbjct: 2995 QDIYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAK 3054

Query: 161  DRDEDSS--IIYS-FKTQQKMFCLDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNN 217
            D D  S+  I YS + +    F LDP +G +  L  L+ +      +YSL  +ATD G  
Sbjct: 3055 DADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRER---IPVYSLMAKATDGGGR 3111

Query: 218  TSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSP 277
                   + +E+V+D    +P                      P+ S+  +   V+EN+ 
Sbjct: 3112 FCQSNIHLILEDVND----NP----------------------PVFSSDHYNTCVYENTA 3145

Query: 278  VDTLVGKVTFTDADWPFNN-MEYTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYK 336
               L+ +V   D D   N  + Y++     G    F I+  +G+I L   L+RE +S Y 
Sbjct: 3146 TKALLTRVQAVDPDIGINRKVVYSLADSAGGV---FSIDSSSGIIILEQPLDREQQSSYN 3202

Query: 337  IAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
            I+V+ TD        P +  S    VTI+VL++ND PPV
Sbjct: 3203 ISVRATD------QSPGQSLSSLTTVTITVLDINDNPPV 3235



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 54/210 (25%), Positives = 96/210 (45%), Gaps = 39/210 (18%)

Query: 141  SINVTEKKSVGEIIARVKATDRDEDSS--IIYSFKTQQKMFCLDPFTGTITLLQPLNLDN 198
            S+N+ E   +G  I +V+A D+D  S+  + YS  T  + F ++  TG + +   L+ ++
Sbjct: 837  SVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRES 896

Query: 199  PSNSKIYSLETEATDNGNNT----SSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVS 254
             +N   YSL+ EA D   +     S  T  VF+++V+D   C P+F              
Sbjct: 897  KAN---YSLKIEARDKAESGQQLFSVVTLKVFLDDVND---CSPAFIP------------ 938

Query: 255  RINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPF-NNMEYTIVGGNLGTPPKFY 313
                       S+++  V E+ PV T++  +   D D      + Y++V    G   +F 
Sbjct: 939  -----------SSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNG---RFE 984

Query: 314  IEPDTGVIKLLDSLNREIESQYKIAVKVTD 343
            I+  +G I+L   L+ E +  Y + V+  D
Sbjct: 985  IDKASGAIRLSKELDYEKQQFYNLTVRAKD 1014



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 62/235 (26%), Positives = 104/235 (44%), Gaps = 40/235 (17%)

Query: 138 PLDSINVTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQKM-FCLDPFTGTITLLQPL 194
           PL    V E   VG  +  V A+D+D  E+  I YS  +   + F ++ FTG I+  + L
Sbjct: 475 PLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEEL 534

Query: 195 NLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVS 254
           + +  S+ +IY     A+D G   S Y                       + + V +R+ 
Sbjct: 535 DFE--SSPEIYRFIVRASDWG---SPYRHE--------------------SEVNVTIRIG 569

Query: 255 RINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGN-LGTPPKFY 313
            +N+ +P+    A    +  + PV   +  V+  D D     ++Y I+ GN LG    FY
Sbjct: 570 NVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDID-ELELVKYKIISGNELGF---FY 625

Query: 314 IEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLN 368
           + PD+GV++L  SL          A+++T  D + + DP+        + ISVL+
Sbjct: 626 LNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPM-------SINISVLH 673



 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 80/313 (25%), Positives = 129/313 (41%), Gaps = 65/313 (20%)

Query: 144  VTEKKSVGEIIARVKATDRDE--DSSIIYSFKTQQK-MFCLDPFTGTITLLQPLNLDNPS 200
            V E  +   ++ RV+A D D   +  ++YS       +F +D  +G I L QPL+ +  S
Sbjct: 3140 VYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQS 3199

Query: 201  NSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELN 260
            +   Y++   ATD     S  + T                       TV + V  IN+  
Sbjct: 3200 S---YNISVRATDQSPGQSLSSLT-----------------------TVTITVLDINDNP 3233

Query: 261  PIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIEPDTG 319
            P+     +  +V E++   T V  V  T  D   N  + Y I  GN     KF I P TG
Sbjct: 3234 PVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGN--EQGKFKINPKTG 3291

Query: 320  VIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPP 379
             I + + L+ E+  ++ + V+  D    A+       S  A V I++ ++ND     NPP
Sbjct: 3292 GISVSEVLDYELCKRFYLVVEAKDGGTPAL-------SAVATVNINLTDVND-----NPP 3339

Query: 380  HLETQIYSTVESFHS------AQLFSKD---SPQEHLSYSIV-GEQDE-----------S 418
                 +YS V S  +        L ++D    P   + +SIV G++D             
Sbjct: 3340 KFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVK 3399

Query: 419  RKKRLEKMSLSSY 431
             KK+L++  +S Y
Sbjct: 3400 VKKKLDRERVSGY 3412



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 71/280 (25%), Positives = 114/280 (40%), Gaps = 43/280 (15%)

Query: 138  PLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQ-----QKMFCLDPFTGTITLLQ 192
            P   + ++E       I +++ATDRDE   + Y+  +       + F +DP TG +   +
Sbjct: 1463 PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAE 1522

Query: 193  PLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVR 252
                          L+ EA D       +   + V         D  F     +  VIV 
Sbjct: 1523 -------------RLDHEAQDK------HILNIMVR--------DQEFPYRRNLARVIVN 1555

Query: 253  VSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPK 311
            V   N+ +P  +   +  SVFE++ + + V +VT  D D   N  + YTI  GN G    
Sbjct: 1556 VEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGN--M 1613

Query: 312  FYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMND 371
            F IEP  G+I +    +     Q+ +++KVTD  +  +       S TA V ISV   ++
Sbjct: 1614 FKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPM-------SATAIVRISVTMSDN 1666

Query: 372  EPPVCNPPHLETQIYSTVESFHSAQLFSKDSPQEHLSYSI 411
              P       + ++   V+   S  L S  S Q  L Y +
Sbjct: 1667 SHPKFIHKDYQAEVNENVDIGTSVILISAIS-QSTLIYEV 1705



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 62/240 (25%), Positives = 107/240 (44%), Gaps = 48/240 (20%)

Query: 151  GEIIARVKATDRDE--DSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNSKIYSLE 208
            G +I +V A D+D+  +  + Y  +     F ++P +G + L +  N D  SN + Y + 
Sbjct: 2100 GTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDL-SNIE-YGVT 2157

Query: 209  TEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAF 268
              A D G                      PS ST   +   IV     N+  P+     +
Sbjct: 2158 ILAKDGGK---------------------PSLSTSVELPITIV-----NKAMPVFDKPFY 2191

Query: 269  TFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPK-FYIEPDTGVIKLLDSL 327
            T SV E+  ++T +  +  T  +     + Y I+ G+   P K F I+ DTGV+K++  L
Sbjct: 2192 TASVNEDIRMNTPILSINATSPEG--QGIIYIIIDGD---PFKQFNIDFDTGVLKVVSPL 2246

Query: 328  NREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVL--NMNDEPPVCNPPHLETQI 385
            + E+ S YK+ ++ +D    A           A+VT+ +L  ++ND PP+ + P   T +
Sbjct: 2247 DYEVTSAYKLTIRASDALTGA----------RAEVTVDLLVNDVNDNPPIFDQPTYNTTL 2296



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 100/406 (24%), Positives = 153/406 (37%), Gaps = 87/406 (21%)

Query: 40   SGVITATKIFNYETDPIRFL-------LIVDTGRLYRHVLTINIIDVPESPNCTADPKFS 92
            SGVIT +       +P+  L       L   T +++  VL  N+            P FS
Sbjct: 2448 SGVITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYS----------PAFS 2497

Query: 93   SGTATLEIDEDYPLFQSIYRVTATDEVFANGDRLNVG--GDHCARPFPLDS---INVTEK 147
              T   E+ E+      +  V ATD       +++     D     F +DS   +  TE+
Sbjct: 2498 QSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTER 2557

Query: 148  KS-----VGEIIARVKATDRD-------------EDSSIIYSFKTQQKMFCLDPFTGT-- 187
                    G++   V+A D               +++     F T +    +    G   
Sbjct: 2558 LDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGH 2617

Query: 188  -ITLLQPLNLDNPSNSKI-YSLETEAT-----------DNG--------NNTSSYTFTVF 226
             +T +Q ++ D+ +NS+I YSL +EA+           DNG        N   +   + F
Sbjct: 2618 LVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFF 2677

Query: 227  VENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVT 286
            V+ VD  I    S      +I V + V       P  + S ++F++ E    DT +G   
Sbjct: 2678 VKAVDGGIPVKHS------LIPVYIHVLPPETFLPSFTQSQYSFTIAE----DTAIGSTV 2727

Query: 287  FTDADWPFNNMEYTIVGGNLGTPPK---FYIEPDTGVIKLLDSLNREIESQYKIAVKVTD 343
             T    P  N+ ++ V G      K   F IE +TG IKL   L+RE    +   V  T 
Sbjct: 2728 DTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT- 2786

Query: 344  LDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPHLETQIYSTV 389
                 IP        T  V I VL++ND  PV      ET  Y T+
Sbjct: 2787 -----IPLDKVDIVFTVDVDIKVLDLNDNKPV-----FETSSYDTI 2822



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 41/140 (29%), Positives = 72/140 (51%), Gaps = 15/140 (10%)

Query: 249  VIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN-MEYTIVG-GNL 306
            V V VS +N+ +P+    A+T  + E+ P + ++ KV+  DAD   N  + Y++ G GN 
Sbjct: 3015 VEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGN- 3073

Query: 307  GTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISV 366
                +F+++P++G +K L  L+RE    Y +  K TD            R   + + + +
Sbjct: 3074 ---SEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGG---------RFCQSNIHLIL 3121

Query: 367  LNMNDEPPVCNPPHLETQIY 386
             ++ND PPV +  H  T +Y
Sbjct: 3122 EDVNDNPPVFSSDHYNTCVY 3141



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 79/354 (22%), Positives = 143/354 (40%), Gaps = 54/354 (15%)

Query: 39   GSGVITATKIFNYETDPIRFLLIVD---TGRLYRHVLTINIIDVPESPNCTADPKFSSGT 95
            GS V+  T +   + +    +  ++   TG +++    + II + + P+ T   +F    
Sbjct: 1582 GSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSI 1641

Query: 96   ATLEIDEDYPLFQSIYRVTATDEVFANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIA 155
               +         +I R++ T  +  N     +  D+ A         V E   +G  + 
Sbjct: 1642 KVTDQGSPPMSATAIVRISVT--MSDNSHPKFIHKDYQAE--------VNENVDIGTSVI 1691

Query: 156  RVKATDRDEDSSIIYSFKTQQ--KMFCLDPFTGTITLLQPLNLDNPSNSKIYSLETEATD 213
             + A  +   S++IY  K      +F ++P++G IT  + L+ +  S+   Y L  +AT+
Sbjct: 1692 LISAISQ---STLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSS---YQLIIQATN 1745

Query: 214  NGNNTSSYTFTVFV--ENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFS 271
                 S+ T  + +  EN + P+     +S              ++E  PI S       
Sbjct: 1746 MAGMASNATVNIQIVDENDNAPVFLFSQYS------------GSLSEAAPINSI----VR 1789

Query: 272  VFENSPVDTLVGKVTFTDADWPFNNM-EYTIVGGNLGTPPKFY-IEPDTGVIKLLDSLNR 329
              +NSP+      +  TDAD   N +  Y IV     T  KF+ ++  TG I+ + +L+ 
Sbjct: 1790 SLDNSPL-----VIRATDADSNRNALLVYQIVES---TAKKFFTVDSSTGAIRTIANLDH 1841

Query: 330  EIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPHLET 383
            E  + +   V V D  +     P        +V I V ++ND PPV      ET
Sbjct: 1842 ETIAHFHFHVHVRDSGS-----PQLTAESPVEVNIEVTDVNDNPPVFTQAVFET 1890



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 84/361 (23%), Positives = 138/361 (38%), Gaps = 80/361 (22%)

Query: 40  SGVITATKIFNYETDPIRFLLIV---DTGRLYRHVLTINIIDVPESPNCTADPKFSSGTA 96
           +GVI+ T+  ++E+ P  +  IV   D G  YRH   +N+                    
Sbjct: 525 TGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT-----------------IR 567

Query: 97  TLEIDEDYPLFQSIYRVTATDEVFANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIAR 156
              ++++ PLF+ +    A   V +               FP           VG  I  
Sbjct: 568 IGNVNDNSPLFEKV----ACQGVISYD-------------FP-----------VGGHITA 599

Query: 157 VKATDRDEDSSIIYSFKTQQKM--FCLDPFTGTITLLQPLNLDNPSNSKIYSLETEATDN 214
           V A D DE   + Y   +  ++  F L+P +G + L + L      N   ++L   ATD 
Sbjct: 600 VSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGN-FALRITATDG 658

Query: 215 GNNTSSYTFTVFVEN---VDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAF--- 268
            N     +  + V +        SC  +         ++++     +LN       F   
Sbjct: 659 ENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSI 718

Query: 269 -------------TFSVFENSPVDTLVGKVTFTDADWPFNN-MEYTIVGGNLGTPPKFYI 314
                          +V E+ PV   + K+   DAD  FN  + +TI  GN  T   F I
Sbjct: 719 NRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGN--TDSCFNI 776

Query: 315 EPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
           + +TG +K+L  ++RE    Y + + + DL N        Q+S    +TI+V + ND  P
Sbjct: 777 DMETGQLKVLMPMDREHTDLYLLNITIYDLGNP-------QKSSWRLLTINVEDANDNSP 829

Query: 375 V 375
           V
Sbjct: 830 V 830



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 50/223 (22%), Positives = 99/223 (44%), Gaps = 37/223 (16%)

Query: 126 LNVGGDHCARPFPLDSINVTEKKSVGEIIARVKATDRDE--DSSIIYSFK--TQQKMFCL 181
           +N  G +  + FP D + V E   VG  I ++KA D D   +  ++++         F +
Sbjct: 718 INRQGPYFDKSFPSD-VAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNI 776

Query: 182 DPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFS 241
           D  TG + +L P++ ++   + +Y L     D GN   S ++ +   NV+D         
Sbjct: 777 DMETGQLKVLMPMDREH---TDLYLLNITIYDLGNPQKS-SWRLLTINVEDA-------- 824

Query: 242 TGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN-MEYT 300
                          N+ +P+    +++ ++ E+S + T + +V   D D   N  + Y+
Sbjct: 825 ---------------NDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYS 869

Query: 301 IVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTD 343
           +    L    +F I   TG++ + D L+RE ++ Y + ++  D
Sbjct: 870 V----LTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARD 908



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 109/449 (24%), Positives = 176/449 (39%), Gaps = 73/449 (16%)

Query: 28   GAGLGPNQIMAGSGVITATKIFNYETDPIRFLLIVDTGR----LYRHV-LTINIIDVPES 82
            G+GLG   I   SGVITA  I + ET    +L +  T R    LY  + + I + DV ++
Sbjct: 1085 GSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDN 1144

Query: 83   PNCTADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVFANGDRLNVGGDHCARPFPLDSI 142
               T++P +        + E+ P   S+ ++ A D   ++ ++L         P    +I
Sbjct: 1145 APLTSEPIYYP-----VVMENSPKDVSVIQIQAEDPDSSSNEKLTY-RITSGNPQNFFAI 1198

Query: 143  NV-----------TEKKSVGEIIARVKATD---RDEDSSIIYSFKTQQKMFCLDPFTGTI 188
            N+            +++   E    V  TD     + S+I    +   +      F   +
Sbjct: 1199 NIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKV 1258

Query: 189  TLLQPLNLDNPSNSK-IYSLETEATDNGNNTS-SYTFT-------VFVENVDDPISCDPS 239
              ++    D     + IY       D G N   SY+          F++     +S    
Sbjct: 1259 YQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQ 1318

Query: 240  FSTGAAIITVIVRV-------SRINELN------PIGSASAFTF-------SVFENSPVD 279
            F+ G+  I  I  V       S    L+      P  S    TF       +V E+  V 
Sbjct: 1319 FTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVT 1378

Query: 280  TLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAV 339
             +VG V+   A+ P   + + IVGGN  +   F  E   G I +   L+ E  S Y ++V
Sbjct: 1379 EIVGVVSVQPANTP---LWFDIVGGNFDS--AFDAEKGVGTIVIAKPLDAEQRSIYNMSV 1433

Query: 340  KVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPHLETQIYSTV-ESFHSAQLF 398
            +VTD  N A+           QV I VL+ ND  P  + P+ +  I   V       Q+ 
Sbjct: 1434 EVTDGTNVAV----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIE 1483

Query: 399  SKDSPQEH-LSYSIVGEQD--ESRKKRLE 424
            + D  ++H LSY++    D    RK R++
Sbjct: 1484 ATDRDEKHKLSYTVHSSIDSISMRKFRID 1512



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 76/282 (26%), Positives = 121/282 (42%), Gaps = 47/282 (16%)

Query: 141  SINVTEKKSVGEIIARVKATDRDED--SSIIYSFKTQQK-MFCLDPFTGTITLLQPLNLD 197
            S+ V E   VG +IA ++  D D      + YS        F +D  +G I L + L+ +
Sbjct: 942  SVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYE 1001

Query: 198  NPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRIN 257
                 + Y+L   A D G                 P+S        +++  V V V  +N
Sbjct: 1002 K---QQFYNLTVRAKDKGR----------------PVSL-------SSVSFVEVEVVDVN 1035

Query: 258  EL--NPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN-MEYTIVGGN-LGTPPKFY 313
            E    P     A   SV ENS + T V +VT  D D   +  ++Y+I  G+ LG   +F 
Sbjct: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLG---RFS 1092

Query: 314  IEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
            I+ ++GVI   D L+RE    Y + V  T  D   +P        T +V I V ++ND  
Sbjct: 1093 IDDESGVITAADILDRETMGSYWLTVYAT--DRGVVP-----LYSTIEVYIEVEDVNDNA 1145

Query: 374  PVCNPP-HLETQIYSTVESFHSAQLFSKD---SPQEHLSYSI 411
            P+ + P +    + ++ +     Q+ ++D   S  E L+Y I
Sbjct: 1146 PLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 71/289 (24%), Positives = 113/289 (39%), Gaps = 45/289 (15%)

Query: 138  PLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQ--KMFCLDPFTGTITLLQPLN 195
            P  + +V E   +   I  + AT   E   IIY        K F +D  TG + ++ PL+
Sbjct: 2189 PFYTASVNEDIRMNTPILSINATS-PEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLD 2247

Query: 196  LDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGA-AIITVIVRVS 254
             +                    TS+Y  T+   +            TGA A +TV + V+
Sbjct: 2248 YEV-------------------TSAYKLTIRASDA----------LTGARAEVTVDLLVN 2278

Query: 255  RINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNM-EYTIVGGNLGTPPKFY 313
             +N+  PI     +  ++ E S + T V +V   DAD   N M  Y IV     +   F+
Sbjct: 2279 DVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFH 2338

Query: 314  IEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
            I+  +G+I     L+ E+     + V+  D    ++       S    V I + ++ND P
Sbjct: 2339 IDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSL-------SSEVLVHIYISDVNDNP 2391

Query: 374  PVCNPPHLETQIYSTVESFH---SAQLFSKDSPQ-EHLSYSIVGEQDES 418
            PV N    E+ +       H     Q    DS   + L YSI+   D +
Sbjct: 2392 PVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRT 2440



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 37/147 (25%), Positives = 72/147 (48%), Gaps = 18/147 (12%)

Query: 249 VIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGT 308
           V ++V  +N+L P+ S + ++ ++ E++P+ T V +VT TDAD   N   Y      +  
Sbjct: 144 VNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDL 203

Query: 309 PPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTD-----LDNDAIPDPLRQRSGTAQVT 363
              F + P +GVI L   LN + +++Y + +   D       N+ +       S TA++ 
Sbjct: 204 ---FSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGV-------SSTAKLY 253

Query: 364 ISVLNMNDEPPVCNPPHLETQIYSTVE 390
           + +  +N+  P     H+ T +  ++E
Sbjct: 254 VHIERINEHAPTI---HVVTHVPFSLE 277



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 54/252 (21%), Positives = 97/252 (38%), Gaps = 39/252 (15%)

Query: 138  PLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLD 197
            P  +  V E   V EI+  V     +               F  +   GTI + +PL+ +
Sbjct: 1365 PFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAE 1424

Query: 198  NPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRIN 257
              S   IY++  E TD                            T  A+  V ++V   N
Sbjct: 1425 QRS---IYNMSVEVTD---------------------------GTNVAVTQVFIKVLDNN 1454

Query: 258  ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGG-NLGTPPKFYIEP 316
            +  P  S   +  ++ E+   DT + ++  TD D   + + YT+    +  +  KF I+P
Sbjct: 1455 DNGPEFSQPNYDVTISEDVLPDTEILQIEATDRD-EKHKLSYTVHSSIDSISMRKFRIDP 1513

Query: 317  DTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVC 376
             TGV+   + L+ E + ++ + + V D +          R   A+V ++V + ND  P  
Sbjct: 1514 STGVLYTAERLDHEAQDKHILNIMVRDQE-------FPYRRNLARVIVNVEDANDHSPYF 1566

Query: 377  NPPHLETQIYST 388
              P  E  ++ +
Sbjct: 1567 TNPLYEASVFES 1578



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 72/321 (22%), Positives = 128/321 (39%), Gaps = 86/321 (26%)

Query: 32   GPNQIMAGSGVITATKIFNYETDPIRFLLIVDTGRLYRHVLT------INIIDVPESPNC 85
            G  +I   +G I+ +++ +YE    RF L+V+        L+      IN+ DV ++P  
Sbjct: 3282 GKFKINPKTGGISVSEVLDYELCK-RFYLVVEAKDGGTPALSAVATVNINLTDVNDNP-- 3338

Query: 86   TADPKFSSGTATLEIDEDYPLFQSIYRVTATDEVFANGDRLNVGGDHCARPFPLDSINVT 145
               PKFS    +  I ED  +  S+  + A D                            
Sbjct: 3339 ---PKFSQDVYSAVISEDALVGDSVILLIAED---------------------------V 3368

Query: 146  EKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNSKIY 205
            + +  G+I   +   DRD +             F +DP  G + + + L+ +  S    Y
Sbjct: 3369 DSQPNGQIHFSIVNGDRDNE-------------FTVDPVLGLVKVKKKLDRERVSG---Y 3412

Query: 206  SLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSA 265
            SL  +A D+G    S T TV   N+D                     +S +N+ +P+ + 
Sbjct: 3413 SLLVQAVDSGIPAMSSTATV---NID---------------------ISDVNDNSPVFTP 3448

Query: 266  SAFTFSVFENSPVDTLVGKVTFTDADWPFNN---MEYTIVGGNLGTPPKFYIEPDTGVIK 322
            + +T  + EN PV T + ++  TD D  F+N     ++I+ GN     +F ++P  G+++
Sbjct: 3449 ANYTAVIQENKPVGTSILQLVVTDRD-SFHNGPPFSFSILSGN--EEEEFVLDPH-GILR 3504

Query: 323  LLDSLNREIESQYKIAVKVTD 343
                       +Y + V+  D
Sbjct: 3505 SAVVFQHTESLEYVLCVQAKD 3525



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 17/190 (8%)

Query: 235  SCDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWP- 293
            S D  F + ++ + V + +S +N+  P+ +   +   V E +P    V  V  +DAD   
Sbjct: 2366 SIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSD 2425

Query: 294  FNNMEYTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPL 353
            F+ +EY+I+ GN  T   F ++  +GVI L +   + +E  Y + V V+D          
Sbjct: 2426 FDRLEYSILSGNDRT--SFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD---------- 2473

Query: 354  RQRSGTAQVTISVLNMNDEPPVCNPPHLETQIYSTVES----FHSAQLFSKDSPQEHLSY 409
               + TAQV I VL  N   P  +      ++   V +     H             +SY
Sbjct: 2474 GLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISY 2533

Query: 410  SIVGEQDESR 419
            +I+ +  + R
Sbjct: 2534 AIINDFAKDR 2543



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 60/282 (21%)

Query: 101  DEDYPLFQSIYRVTATDEVFANGDRLNVGGDHCARPF---PLDSINVTEKKSVGEIIARV 157
            D+++P  +++ RV    E            DH   P+   PL   +V E  ++G  + +V
Sbjct: 1540 DQEFPYRRNLARVIVNVED---------ANDHS--PYFTNPLYEASVFESAALGSAVLQV 1588

Query: 158  KATDRD--EDSSIIYSFKTQQ--KMFCLDPFTGTITLLQPLNLDNPSNSKIYSLETEATD 213
             A D+D  E++ +IY+ +      MF ++P  G IT+ +  ++        + L  + TD
Sbjct: 1589 TALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQ---FVLSIKVTD 1645

Query: 214  NGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVF 273
             G+   S T                      AI+ + V +S  +  +P      +   V 
Sbjct: 1646 QGSPPMSAT----------------------AIVRISVTMS--DNSHPKFIHKDYQAEVN 1681

Query: 274  ENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIES 333
            EN  + T V  ++        + + Y +  G++     F I P +GVI    +L+ E  S
Sbjct: 1682 ENVDIGTSVILISAISQ----STLIYEVKDGDINGI--FTINPYSGVITTQKALDYERTS 1735

Query: 334  QYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
             Y++ ++ T++   A           A V I +++ ND  PV
Sbjct: 1736 SYQLIIQATNMAGMA---------SNATVNIQIVDENDNAPV 1768



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 57/244 (23%), Positives = 99/244 (40%), Gaps = 46/244 (18%)

Query: 144  VTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQK------MFCLDPFTGTITLLQPLN 195
            + E   VG  + +V+A D D   +  + YS  +  +       F +D  TG I+ L+ L+
Sbjct: 2823 IMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLD 2882

Query: 196  LDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSR 255
                        ET+ T        +TF+V   ++ +  S        ++   V VRV+ 
Sbjct: 2883 H-----------ETDPT--------FTFSVVASDLGEAFSL-------SSTALVSVRVTD 2916

Query: 256  INELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN--MEYTIVGGNLGTPPKFY 313
            IN+  P+ +   +  +V E+ P   +V  ++  D D    N  + Y I GGN        
Sbjct: 2917 INDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALG 2976

Query: 314  IEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
            +      + +   L+RE +  Y + +  TD                A V +SV ++ND  
Sbjct: 2977 LVQSEWKVYVKRPLDREEQDIYFLNITATD----------GLFVTQAMVEVSVSDVNDNS 3026

Query: 374  PVCN 377
            PVC+
Sbjct: 3027 PVCD 3030



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 31/94 (32%), Positives = 45/94 (47%), Gaps = 10/94 (10%)

Query: 141 SINVTEKKSVGEIIARVKATDRDEDSS--IIYSFKTQQKMFCLDPFTGTITLLQPLNLDN 198
           S+ + E   +   +A+V ATD D  S+    Y FK +  +F + P +G I+L   LN D 
Sbjct: 164 SVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDE 223

Query: 199 PSNSKIYSLETEATDN-----GNNTSSYTFTVFV 227
            +    Y LE  A D      GNN  S T  ++V
Sbjct: 224 KNR---YDLEILAVDRGMKLYGNNGVSSTAKLYV 254



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 44/192 (22%), Positives = 85/192 (44%), Gaps = 35/192 (18%)

Query: 157  VKATDRDEDSSIIYSFK----TQQKMFCLDPFTGTITLLQPLNLDNPSNSKIYSLETEAT 212
            ++ATD D + + +  ++    T +K F +D  TG I  +   NLD+ +            
Sbjct: 1798 IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIA--NLDHET------------ 1843

Query: 213  DNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSV 272
                  + + F V V +   P        T  + + V + V+ +N+  P+ + + F   +
Sbjct: 1844 -----IAHFHFHVHVRDSGSPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETIL 1892

Query: 273  FENSPVDTLVGKVTFTDADWPF-NNMEYTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREI 331
               + V   V KV+ TD D      + Y+++ G+L     F I+ ++GV+ + +  N   
Sbjct: 1893 LLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSL---DHFLIDSNSGVLTIKN--NNLS 1947

Query: 332  ESQYKIAVKVTD 343
            +  Y + VKV+D
Sbjct: 1948 KDHYMLIVKVSD 1959



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 65/290 (22%), Positives = 102/290 (35%), Gaps = 49/290 (16%)

Query: 144  VTEKKSVGEIIARVKATDRDEDS--SIIYSFKT--QQKMFCLDPFTGTITLLQPLNLDNP 199
            V+E    G  +  V+A+D D      + YS  +   +  F +D  +G ITL    N    
Sbjct: 2403 VSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLS---NHRKQ 2459

Query: 200  SNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINEL 259
                +YSL    +D       +T T  V                       +RV   N  
Sbjct: 2460 RMEPLYSLNVSVSDG-----LFTSTAQVH----------------------IRVLGANLY 2492

Query: 260  NPIGSASAFTFSVFENSPVDTLVGKVTFTDAD-WPFNNMEYTIVGGNLGTPPKFYIEPDT 318
            +P  S S +   V EN    T V  V  TD D   +  + Y I+  N     +F I+   
Sbjct: 2493 SPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAII--NDFAKDRFLID-SN 2549

Query: 319  GVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNP 378
            G +   + L+RE   +  +++ V  LD          R+    V + V++ ND  P    
Sbjct: 2550 GQVITTERLDRENPLEGDVSIFVRALDGGG-------RTTFCTVRVIVVDENDNAPQFMT 2602

Query: 379  PHLETQIYSTVESFHSA----QLFSKDSPQEHLSYSIVGEQDESRKKRLE 424
                  + + V   H       +   D     ++YS+  E   S    LE
Sbjct: 2603 VEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLE 2652



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 16/104 (15%)

Query: 312 FYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMND 371
           F I P +G+I     LN   +  YK+  +VT+ + D            AQVTIS+ + ND
Sbjct: 420 FKINPRSGLIVTARPLNTVKKEVYKL--EVTNKEGDL----------KAQVTISIEDAND 467

Query: 372 EPPVCNPPHLETQIYSTV---ESFHSAQLFSKDSPQE-HLSYSI 411
             P    P  +  +  +V    S  +     KD  +  +++YSI
Sbjct: 468 HTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI 511



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 23/100 (23%), Positives = 48/100 (48%), Gaps = 4/100 (4%)

Query: 245  AIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGG 304
            A + V V +  IN+ +P+     +  +V  ++   TL+ +VT  D D   N     ++  
Sbjct: 2066 ARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQD 2125

Query: 305  NLGTPPKFYIEPDTGVIKLLDSLNREIES-QYKIAVKVTD 343
            + G    F I P++G + L ++ N ++ + +Y + +   D
Sbjct: 2126 DYG---HFEINPNSGNVILKEAFNSDLSNIEYGVTILAKD 2162


>gi|157426847 protocadherin 19 isoform a [Homo sapiens]
          Length = 1101

 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 68/253 (26%), Positives = 117/253 (46%), Gaps = 30/253 (11%)

Query: 142 INVTEKKSVGEIIARVKATDRDEDSSIIYSFK-TQQKMFCLDPFTGTITLLQPLNLDNPS 200
           + ++E  S G  I    A D D  S  + +++ T  ++F L+  T               
Sbjct: 136 LEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT------------RGD 183

Query: 201 NSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELN 260
            S+   L  E + +    S Y+F +   +  DP    P   T    + + ++V+  N+ N
Sbjct: 184 GSRFAELVVEKSLDRETQSHYSFRITALDGGDP----PRLGT----VGLSIKVTDSNDNN 235

Query: 261 PIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVG-GNLGTPPKFYIEPDT 318
           P+ S S +  SV ENSP +T V ++  +D D   N  + Y+  G  N  T   F I+P +
Sbjct: 236 PVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHS 295

Query: 319 GVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNP 378
           G++ +  +L+ E    Y++ V+  DL  ++IP          +VT+SVL+ ND PPV N 
Sbjct: 296 GLVTVTGALDYEEGHVYELDVQAKDLGPNSIP-------AHCKVTVSVLDTNDNPPVINL 348

Query: 379 PHLETQIYSTVES 391
             + +++    ES
Sbjct: 349 LSVNSELVEVSES 361



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 61/248 (24%), Positives = 93/248 (37%), Gaps = 43/248 (17%)

Query: 142 INVTEKKSVGEIIARVKATDRDED-SSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPS 200
           + V+E    G +IA V+ +DRD   +  +         F L  +    T+L    LD   
Sbjct: 356 VEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQ 415

Query: 201 NSKIYSLETEATDNG----NNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRI 256
           + + Y+L  +A D G     +  S+T  +  EN + P    P +        VIV+ +  
Sbjct: 416 HDQ-YNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQ-------VIVQEN-- 465

Query: 257 NELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKF---Y 313
                  +  A+  SV    P   L G V+            Y IV   +   P F    
Sbjct: 466 ------NTPGAYLLSVSARDPDLGLNGSVS------------YQIVPSQVRDMPVFTYVS 507

Query: 314 IEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
           I P++G I  L S N E    ++  V   D         L      A V + +L++ND  
Sbjct: 508 INPNSGDIYALRSFNHEQTKAFEFKVLAKD-------GGLPSLQSNATVRVIILDVNDNT 560

Query: 374 PVCNPPHL 381
           PV   P L
Sbjct: 561 PVITAPPL 568


>gi|157426845 protocadherin 19 isoform b [Homo sapiens]
          Length = 1100

 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 68/253 (26%), Positives = 117/253 (46%), Gaps = 30/253 (11%)

Query: 142 INVTEKKSVGEIIARVKATDRDEDSSIIYSFK-TQQKMFCLDPFTGTITLLQPLNLDNPS 200
           + ++E  S G  I    A D D  S  + +++ T  ++F L+  T               
Sbjct: 136 LEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT------------RGD 183

Query: 201 NSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELN 260
            S+   L  E + +    S Y+F +   +  DP    P   T    + + ++V+  N+ N
Sbjct: 184 GSRFAELVVEKSLDRETQSHYSFRITALDGGDP----PRLGT----VGLSIKVTDSNDNN 235

Query: 261 PIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVG-GNLGTPPKFYIEPDT 318
           P+ S S +  SV ENSP +T V ++  +D D   N  + Y+  G  N  T   F I+P +
Sbjct: 236 PVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHS 295

Query: 319 GVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNP 378
           G++ +  +L+ E    Y++ V+  DL  ++IP          +VT+SVL+ ND PPV N 
Sbjct: 296 GLVTVTGALDYEEGHVYELDVQAKDLGPNSIP-------AHCKVTVSVLDTNDNPPVINL 348

Query: 379 PHLETQIYSTVES 391
             + +++    ES
Sbjct: 349 LSVNSELVEVSES 361



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 61/248 (24%), Positives = 93/248 (37%), Gaps = 43/248 (17%)

Query: 142 INVTEKKSVGEIIARVKATDRDED-SSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPS 200
           + V+E    G +IA V+ +DRD   +  +         F L  +    T+L    LD   
Sbjct: 356 VEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQ 415

Query: 201 NSKIYSLETEATDNG----NNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRI 256
           + + Y+L  +A D G     +  S+T  +  EN + P    P +        VIV+ +  
Sbjct: 416 HDQ-YNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQ-------VIVQEN-- 465

Query: 257 NELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKF---Y 313
                  +  A+  SV    P   L G V+            Y IV   +   P F    
Sbjct: 466 ------NTPGAYLLSVSARDPDLGLNGSVS------------YQIVPSQVRDMPVFTYVS 507

Query: 314 IEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
           I P++G I  L S N E    ++  V   D         L      A V + +L++ND  
Sbjct: 508 INPNSGDIYALRSFNHEQTKAFEFKVLAKD-------GGLPSLQSNATVRVIILDVNDNT 560

Query: 374 PVCNPPHL 381
           PV   P L
Sbjct: 561 PVITAPPL 568


>gi|40255133 hypothetical protein LOC222256 [Homo sapiens]
          Length = 885

 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 67/249 (26%), Positives = 111/249 (44%), Gaps = 42/249 (16%)

Query: 141 SINVTEKKSVGEIIARVKATDRDEDSSII---YSFKTQQKM-----FCLDPF-TGTITLL 191
           SI V E+ + G ++  +     D+DS      ++F     +     F  DP  +G I L+
Sbjct: 351 SIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLI 410

Query: 192 QPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIV 251
             L+ +NPSN             GN    YT  + V++V  P   +  +        V +
Sbjct: 411 GDLDYENPSNLAA----------GNK---YTVIIQVQDVAPPYYKNNVY--------VYI 449

Query: 252 RVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIV--GGNLGTP 309
             S  NE   I    ++ F V E  P  T VG+V  TD D P +++ Y+I   G +L  P
Sbjct: 450 LTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYP 509

Query: 310 PKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNM 369
             F+I P TG ++L+  ++ E    Y + ++ T+           + + +  VT+++L  
Sbjct: 510 NVFWINPKTGELQLVTKVDCETTPIYILRIQATN----------NEDTSSVTVTVNILEE 559

Query: 370 NDEPPVCNP 378
           NDE P+C P
Sbjct: 560 NDEKPICTP 568



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 67/248 (27%), Positives = 106/248 (42%), Gaps = 59/248 (23%)

Query: 143 NVTEKKSVGEIIARVKATDRD-EDSSIIYSFKT------QQKMFCLDPFTGTITLLQPLN 195
           +V+E++     + +V+ATD+D   SS++YS  T         +F ++P TG + L+  ++
Sbjct: 469 DVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVD 528

Query: 196 LDNPSNSKIYSLETEATDNGNNTSSYTFTVFV--ENVDDPISCDPSFSTGAAIITVIVRV 253
            +    + IY L  +AT+N  +TSS T TV +  EN + PI C P+              
Sbjct: 529 CET---TPIYILRIQATNN-EDTSSVTVTVNILEENDEKPI-CTPN-------------- 569

Query: 254 SRINELNPIGSASAFTFSVFENSPVDTLVG------KVTFTDADWPFNNMEYTIVGGNLG 307
                            S F   PVD  VG      K+T TD D    +  Y+I  GN+ 
Sbjct: 570 -----------------SYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVN 612

Query: 308 TPPKFYIEPDTGVIKLLDSLNREIES------QYKIAVKVTD--LDNDAIPDPLRQRSGT 359
               F     + V +LL +   +          YK+ V VTD  L +D         +GT
Sbjct: 613 NHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGT 672

Query: 360 AQVTISVL 367
             ++I V+
Sbjct: 673 VTLSIKVI 680



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 78/300 (26%), Positives = 124/300 (41%), Gaps = 60/300 (20%)

Query: 72  LTINIIDVPESPNCTADPKFSSGTATLEIDEDYPLFQSIYRVT------ATDEVFANGDR 125
           L+  +I  P+S   +A+    S T  L+ +  +  F  I  V       A+ E+  N   
Sbjct: 170 LSYFLISPPKSFRMSANGTLFS-TTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVN 228

Query: 126 LNVGGDHCAR-PFPLDSINVTEKKSVGEIIARVKATDRDED---SSIIYSFKTQQKMFCL 181
           LN   D   R   P     V E+ S G I+A + A D D++   S ++YS  T  K F +
Sbjct: 229 LN---DEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMI 285

Query: 182 DPFTGTITLLQPLNLD--NPSNSKIYSLETEATDN--GNNTSSYTFTVFVENVDDPISCD 237
           +  TGTI + Q ++ D      +   SLE    D   G   +    T  VE+V+D     
Sbjct: 286 NQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVND----- 340

Query: 238 PSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVF--ENSPVDTL---VGKVTF-TDAD 291
                                 NP  +   FTFS+   E +   TL   + K  F  D++
Sbjct: 341 ----------------------NP-ATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSE 377

Query: 292 WPFNNMEYTIVGGNLGTPPKFYIEP-DTGVIKLLDSLNREIES------QYKIAVKVTDL 344
            P N   +T+  G +G+  +F  +P  +G I L+  L+ E  S      +Y + ++V D+
Sbjct: 378 APNNRFNFTMPSG-VGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDV 436



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 57/243 (23%), Positives = 102/243 (41%), Gaps = 51/243 (20%)

Query: 144 VTEKKSVGEIIARVKATDRDEDSSII---YSFKTQQKMFCLDPFTGTITLLQPLNLDNPS 200
           + E+ + G  I +V+A D ++ S  I   Y   +  K F +   +   TL     LD  +
Sbjct: 144 IVERANPG-FIYQVEAFDPEDTSRNIPLSYFLISPPKSFRM---SANGTLFSTTELDFEA 199

Query: 201 NSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELN 260
             + + L  E  D+G   +S    V + N++D +   P F++   + TV+       EL+
Sbjct: 200 GHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEV---PRFTSPTRVYTVL------EELS 250

Query: 261 PIGSASAFTFSVFENSPVDTLVGKVTFTDAD---WPFNNMEYTIVGGNLGTPPKFY-IEP 316
           P                  T+V  +T  D D   +P +++ Y+I      T  K++ I  
Sbjct: 251 P-----------------GTIVANITAEDPDDEGFP-SHLLYSIT-----TVSKYFMINQ 287

Query: 317 DTGVIKLLDSLNR---EIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEP 373
            TG I++   ++R   E+     I+++V   D      P   +    Q+T  V ++ND P
Sbjct: 288 LTGTIQVAQRIDRDAGELRQNPTISLEVLVKDR-----PYGGQENRIQITFIVEDVNDNP 342

Query: 374 PVC 376
             C
Sbjct: 343 ATC 345


>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
          Length = 785

 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 63/215 (29%), Positives = 97/215 (45%), Gaps = 38/215 (17%)

Query: 165 DSSIIY--SFKTQQKMFCLDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYT 222
           D SI Y  S +    +F +D  TG I   + L+ +  +    Y+L  +A D   N     
Sbjct: 79  DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQA---YYTLRAQALDRLTNK---- 131

Query: 223 FTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLV 282
                     P+  +  F         ++++  IN+  P      +T  V E SPV T V
Sbjct: 132 ----------PVEPESEF---------VIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSV 172

Query: 283 GKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTGVIK-LLDSLNREIESQYKIAVKV 341
            +VT TDAD P       +V   L   P F +EP TGVIK  L +++RE + QY + ++ 
Sbjct: 173 VQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQA 232

Query: 342 TDL--DNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
            D+   N  +       SGT  VT+++ ++ND PP
Sbjct: 233 KDMVGQNGGL-------SGTTSVTVTLTDVNDNPP 260



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 72/287 (25%), Positives = 120/287 (41%), Gaps = 36/287 (12%)

Query: 144 VTEKKSVGEIIARVKATDRDE-----DSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDN 198
           V E   VG  + +V ATD D+      + ++YS    Q  F ++P TG I    P N+D 
Sbjct: 162 VPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALP-NMDR 220

Query: 199 PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
            +  + Y L  +A D        + T                       +V V ++ +N+
Sbjct: 221 EAKDQ-YLLVIQAKDMVGQNGGLSGTT----------------------SVTVTLTDVND 257

Query: 259 LNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIEPD 317
             P     ++ ++V E+ PV ++V ++   DAD   N  MEY IV G+     K  ++ +
Sbjct: 258 NPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKE 317

Query: 318 T--GVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
           T  G+I +   L+ E ++ Y + ++  + D D     L   S T  V I V ++ DEPPV
Sbjct: 318 TQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDV-DEPPV 376

Query: 376 CNPPHLETQIYSTVE---SFHSAQLFSKDSPQEHLSYSIVGEQDESR 419
            + P    ++    +      +      DS    + YSI    D  R
Sbjct: 377 FSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLER 423



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 60/235 (25%), Positives = 102/235 (43%), Gaps = 27/235 (11%)

Query: 143 NVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNS 202
           NV E   V  ++AR+KA D D  ++    +K            G    +  +++D  +  
Sbjct: 270 NVPESLPVASVVARIKAADADIGANAEMEYKI---------VDGDGLGIFKISVDKETQE 320

Query: 203 KIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF-STG--AAIITVIVRVSRINEL 259
            I +++ E        +SYT  +   N D     DP F S G  +   TV + V  ++E 
Sbjct: 321 GIITIQKELDFEAK--TSYTLRIEAANKD----ADPRFLSLGPFSDTTTVKIIVEDVDE- 373

Query: 260 NPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTG 319
            P+ S+  +   V E + V  ++G V   D D   + + Y+I   N      F I+ ++G
Sbjct: 374 PPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSI-DRNTDLERYFNIDANSG 432

Query: 320 VIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
           VI    SL+RE  + + I V   +  N +       + G   V I++L++ND  P
Sbjct: 433 VITTAKSLDRETNAIHNITVLAMESQNPS-------QVGRGYVAITILDINDNAP 480



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 53/238 (22%), Positives = 90/238 (37%), Gaps = 44/238 (18%)

Query: 138 PLDSINVTEKKSVGEIIARVKATDRDEDSSII-YSFKTQ---QKMFCLDPFTGTITLLQP 193
           PL  + V+E   VG II  V A D D  +S + YS       ++ F +D  +G IT  + 
Sbjct: 380 PLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKS 439

Query: 194 LNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRV 253
           L+            ET A  N         TV      +P      +        V + +
Sbjct: 440 LDR-----------ETNAIHN--------ITVLAMESQNPSQVGRGY--------VAITI 472

Query: 254 SRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEY-----TIVGGNLGT 308
             IN+  P   A  +  +V EN+    ++ K++  D D P N  ++     T    N   
Sbjct: 473 LDINDNAP-EFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNF 531

Query: 309 PPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISV 366
             K   +    ++   +   R+ +S Y + + + D  + ++       S T  +TI V
Sbjct: 532 SLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSL-------SSTNTLTIRV 582


>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
          Length = 785

 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 63/215 (29%), Positives = 97/215 (45%), Gaps = 38/215 (17%)

Query: 165 DSSIIY--SFKTQQKMFCLDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYT 222
           D SI Y  S +    +F +D  TG I   + L+ +  +    Y+L  +A D   N     
Sbjct: 79  DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQA---YYTLRAQALDRLTNK---- 131

Query: 223 FTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLV 282
                     P+  +  F         ++++  IN+  P      +T  V E SPV T V
Sbjct: 132 ----------PVEPESEF---------VIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSV 172

Query: 283 GKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTGVIK-LLDSLNREIESQYKIAVKV 341
            +VT TDAD P       +V   L   P F +EP TGVIK  L +++RE + QY + ++ 
Sbjct: 173 VQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQA 232

Query: 342 TDL--DNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
            D+   N  +       SGT  VT+++ ++ND PP
Sbjct: 233 KDMVGQNGGL-------SGTTSVTVTLTDVNDNPP 260



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 72/287 (25%), Positives = 120/287 (41%), Gaps = 36/287 (12%)

Query: 144 VTEKKSVGEIIARVKATDRDE-----DSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDN 198
           V E   VG  + +V ATD D+      + ++YS    Q  F ++P TG I    P N+D 
Sbjct: 162 VPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALP-NMDR 220

Query: 199 PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
            +  + Y L  +A D        + T                       +V V ++ +N+
Sbjct: 221 EAKDQ-YLLVIQAKDMVGQNGGLSGTT----------------------SVTVTLTDVND 257

Query: 259 LNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIEPD 317
             P     ++ ++V E+ PV ++V ++   DAD   N  MEY IV G+     K  ++ +
Sbjct: 258 NPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKE 317

Query: 318 T--GVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
           T  G+I +   L+ E ++ Y + ++  + D D     L   S T  V I V ++ DEPPV
Sbjct: 318 TQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDV-DEPPV 376

Query: 376 CNPPHLETQIYSTVE---SFHSAQLFSKDSPQEHLSYSIVGEQDESR 419
            + P    ++    +      +      DS    + YSI    D  R
Sbjct: 377 FSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLER 423



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 60/235 (25%), Positives = 102/235 (43%), Gaps = 27/235 (11%)

Query: 143 NVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNS 202
           NV E   V  ++AR+KA D D  ++    +K            G    +  +++D  +  
Sbjct: 270 NVPESLPVASVVARIKAADADIGANAEMEYKI---------VDGDGLGIFKISVDKETQE 320

Query: 203 KIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSF-STG--AAIITVIVRVSRINEL 259
            I +++ E        +SYT  +   N D     DP F S G  +   TV + V  ++E 
Sbjct: 321 GIITIQKELDFEAK--TSYTLRIEAANKD----ADPRFLSLGPFSDTTTVKIIVEDVDE- 373

Query: 260 NPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTG 319
            P+ S+  +   V E + V  ++G V   D D   + + Y+I   N      F I+ ++G
Sbjct: 374 PPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSI-DRNTDLERYFNIDANSG 432

Query: 320 VIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
           VI    SL+RE  + + I V   +  N +       + G   V I++L++ND  P
Sbjct: 433 VITTAKSLDRETNAIHNITVLAMESQNPS-------QVGRGYVAITILDINDNAP 480



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 53/238 (22%), Positives = 90/238 (37%), Gaps = 44/238 (18%)

Query: 138 PLDSINVTEKKSVGEIIARVKATDRDEDSSII-YSFKTQ---QKMFCLDPFTGTITLLQP 193
           PL  + V+E   VG II  V A D D  +S + YS       ++ F +D  +G IT  + 
Sbjct: 380 PLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKS 439

Query: 194 LNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRV 253
           L+            ET A  N         TV      +P      +        V + +
Sbjct: 440 LDR-----------ETNAIHN--------ITVLAMESQNPSQVGRGY--------VAITI 472

Query: 254 SRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEY-----TIVGGNLGT 308
             IN+  P   A  +  +V EN+    ++ K++  D D P N  ++     T    N   
Sbjct: 473 LDINDNAP-EFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNF 531

Query: 309 PPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISV 366
             K   +    ++   +   R+ +S Y + + + D  + ++       S T  +TI V
Sbjct: 532 SLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSL-------SSTNTLTIRV 582


>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
          Length = 2916

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 66/246 (26%), Positives = 110/246 (44%), Gaps = 49/246 (19%)

Query: 142  INVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQP-LNLDNPS 200
            + V E   VG  +  + ATD + + +I Y   +  K F +DP  GTI  + P L LD  S
Sbjct: 1999 VTVPESIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTIS 2058

Query: 201  NSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELN 260
             ++      EA+D GN                     P      A+  V + +  +N   
Sbjct: 2059 TTQFL---VEASDGGN---------------------PDL---RALTLVEIGIEDMNNYA 2091

Query: 261  PIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN--MEYTIVGGNLGTPPKFYIE--- 315
            P  +  ++  S+ E++ V + +   +  D DW   N  +EY+I+ GN  +   F++E   
Sbjct: 2092 PEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGN--SQNNFHVETKF 2149

Query: 316  -------PDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLN 368
                      G + LL SL+RE  + +++ +    L +D+   PL   S TA ++I VL+
Sbjct: 2150 FHSEYPYKQVGYLVLLHSLDREASASHELVI----LASDSGCPPL---SSTAVISIQVLD 2202

Query: 369  MNDEPP 374
            +ND PP
Sbjct: 2203 VNDNPP 2208



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 69/281 (24%), Positives = 119/281 (42%), Gaps = 46/281 (16%)

Query: 143  NVTEKKSVGEIIARVKATDRDE--DSSIIYSFKT--QQKMFCLDPFTGTITLLQPLNLDN 198
            +V+E +     + +V ATD D   +  I YS  +  Q++ F +D  +G IT    L+ + 
Sbjct: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854

Query: 199  PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
             S+   YSL  +ATD G    S T TV    V D     P+F    A+            
Sbjct: 1855 TSS---YSLIVQATDKGMPRLSNT-TVIKVQVTDINDNAPAFLPSEAV------------ 1898

Query: 259  LNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDT 318
                         + E+S    +V  V+  D D     +       N GT  KF I+ +T
Sbjct: 1899 ------------EITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGT--KFAIDQNT 1944

Query: 319  GVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNP 378
            GV+ L+ +L+ E  ++Y++ ++++D         +    G   + + VL++ND PPV + 
Sbjct: 1945 GVVVLVKTLDFEEMTEYELLIQISD--------SVHYTEGA--LVVRVLDVNDNPPVFSQ 1994

Query: 379  PHLETQIYSTVESFHSAQLFSKD--SPQEHLSYSIVGEQDE 417
               +  +  ++   +S    S       E++SY I+    E
Sbjct: 1995 DFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKE 2035



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 67/239 (28%), Positives = 101/239 (42%), Gaps = 40/239 (16%)

Query: 144  VTEKKSVGEIIARVKATDRDE---DSSIIYSFKTQQK--MFCLDPFTGTITLLQPLNLDN 198
            + E     +I++ +K++D  +   +  + +S     K   F +D  TG + L + L+ + 
Sbjct: 957  IPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET 1016

Query: 199  PSNSKIYSLETEATDNGNNTSSYTFTVFVE-NVDDPISCDPSFSTGAAIITVIVRVSRIN 257
             S+   Y      TD+  N S  + TVF+  +V+D     PSF     +I          
Sbjct: 1017 TSH---YLFRVITTDHSKNLS-LSSTVFLSIDVEDQNDHSPSFQDELIVI---------- 1062

Query: 258  ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNN--MEYTIVGGNLGTPPKFYIE 315
                         SV EN P+ TLV      D D  F N  ++Y I   N GT P F I 
Sbjct: 1063 -------------SVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNP-FLIH 1108

Query: 316  PDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
            P  G +  +  L+R  ES   + + VT  D        R RS TAQ+ I  L++ND  P
Sbjct: 1109 PSFGTLVTVSRLDR--ESIPTVILTVTASDQAVNVTDRRLRSLTAQIVI--LDVNDHNP 1163



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 89/411 (21%), Positives = 159/411 (38%), Gaps = 76/411 (18%)

Query: 44   TATKIFNYETDPIRFLLIVDTGRLYRHVLTINIIDVPESPNCTADPKFSSGTATLEIDED 103
            T   +FN + D   FL      R+  ++ + N    P +      P F +      +D +
Sbjct: 1072 TLVYVFNAKDDDGSFL----NSRIQYYIESHN----PGTNPFLIHPSFGTLVTVSRLDRE 1123

Query: 104  YPLFQSIYRVTATDEVFANGDR-----------LNVGGDHCARPFPLDSINVTEKKSVGE 152
              +   I  VTA+D+     DR           L+V  DH        + +V E  +VG 
Sbjct: 1124 -SIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVN-DHNPTFISFPNAHVKEDVTVGS 1181

Query: 153  IIARVKATDRDE--DSSIIYSFKT--QQKMFCLDPFTGTITLLQPLNLDNPSNSKIYSLE 208
            ++  + A D DE  +  + YS  +  +   F LD  +G +T   PL+         Y ++
Sbjct: 1182 LVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLD---------YEMK 1232

Query: 209  TEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAF 268
            T+          +  TV    +DD     P+ S+     T+ V V  +N+  P+     +
Sbjct: 1233 TQ----------HILTVLA--LDDG---TPALSSSQ---TLTVTVLDVNDEAPVFKQHLY 1274

Query: 269  TFSVFENSPVDTLVGKVTFTDADWPFNN-MEYTIVGGNLGTPPKFYIEPDTGVIKLLDSL 327
              SV EN      V +V   D D   N+ +++ I+ G   +   F I  DTG +     L
Sbjct: 1275 EASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPG--ASFELFEINSDTGEVVTTTIL 1332

Query: 328  NREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPHLETQIYS 387
            +REI+  + + V V D    ++       S T  +  +V + ND  P             
Sbjct: 1333 DREIQEVFTLRVLVRDGGFPSL-------SSTTTILCTVEDENDHAP------------E 1373

Query: 388  TVESFHSAQLFSKDSPQEHLSYSIVGEQDESRKKRLEKMSLSSYYFKKCFT 438
             + S +  ++     P+  + Y+++    ++   R  +  +      +CFT
Sbjct: 1374 FIVSSYDIEVLENQEPE--VVYTVLASDMDAGNNRAVEYHIIDGNTDECFT 1422



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 70/278 (25%), Positives = 108/278 (38%), Gaps = 42/278 (15%)

Query: 98   LEIDEDYPLFQSIYRVTATDEVFANGDRLNVGGDHCARPFPLDSINVTEKKSVGEIIARV 157
            L +D+  P   S   +T T  V    D   V   H      L   +V E ++ GE + RV
Sbjct: 1240 LALDDGTPALSSSQTLTVT--VLDVNDEAPVFKQH------LYEASVKENQNPGEFVTRV 1291

Query: 158  KATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNN 217
            +A DRD   +    F+            G    L  +N D         L+ E  +    
Sbjct: 1292 EALDRDSGVNSKLQFEI---------MPGASFELFEINSDTGEVVTTTILDREIQE---- 1338

Query: 218  TSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSP 277
               +T  V V         D  F + ++  T++  V   N+  P    S++   V EN  
Sbjct: 1339 --VFTLRVLVR--------DGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQE 1388

Query: 278  VDTLVGKVTFTDADWPFNN-MEYTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYK 336
             + +V  V  +D D   N  +EY I+ GN  T   F I   +G +    +L+RE  S + 
Sbjct: 1389 PE-VVYTVLASDMDAGNNRAVEYHIIDGN--TDECFTINEMSGELSTTRALDREQISNFT 1445

Query: 337  IAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
            + +  +DL      DP   RS    + + VL+ ND  P
Sbjct: 1446 LVILCSDLG-----DP--PRSSVIHLQVRVLDANDHSP 1476



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 49/185 (26%), Positives = 87/185 (47%), Gaps = 25/185 (13%)

Query: 236  CDPSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN 295
            C P  ST      + ++V  +N+  P  S+ ++   V E++P+ + +  V+  D D   +
Sbjct: 2187 CPPLSSTAV----ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSH 2242

Query: 296  -NMEYTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLR 354
              + Y I+ GN      FY+E +TGV+ L+  L+ E  +++ + V+ +D +        +
Sbjct: 2243 AEIIYNIISGN--EKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE--------K 2292

Query: 355  QRSGTAQVTISVLNMNDEPP-------VCNPPHLETQIYSTVESFHSAQLFSKDSPQEHL 407
            +    A V +SVL+ ND  P        C  P     I ST+ S ++    +   P   L
Sbjct: 2293 KHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPE-NLPISSTICSINALDFDA--GPYGEL 2349

Query: 408  SYSIV 412
            +YSIV
Sbjct: 2350 TYSIV 2354



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 45/194 (23%), Positives = 81/194 (41%), Gaps = 38/194 (19%)

Query: 131  DHCARPFPLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQK---MFCLDPFTGT 187
            D+     P +++ +TE    G I+  V   D D +S+ I+SF  +      F +D  TG 
Sbjct: 1887 DNAPAFLPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGV 1946

Query: 188  ITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAII 247
            + L++ L+ +  +    Y L  + +D+ + T                             
Sbjct: 1947 VVLVKTLDFEEMTE---YELLIQISDSVHYTEG--------------------------- 1976

Query: 248  TVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLG 307
             ++VRV  +N+  P+ S   +  +V E+ PV   V  ++ TD +    N+ Y I    L 
Sbjct: 1977 ALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLE-SNENISYRI----LS 2031

Query: 308  TPPKFYIEPDTGVI 321
            +  +F I+P  G I
Sbjct: 2032 SSKEFSIDPKNGTI 2045



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 44/168 (26%), Positives = 74/168 (44%), Gaps = 19/168 (11%)

Query: 209  TEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPIGSASAF 268
            T A D     S++T  +   ++ DP          +++I + VRV   N+ +P      +
Sbjct: 1433 TRALDR-EQISNFTLVILCSDLGDP--------PRSSVIHLQVRVLDANDHSPSFPTLYY 1483

Query: 269  TFSVFENSPVDTLVGKVTFTDADWPFNNM-EYTIVGGNLGTPPKFYIEPDTGVIKLLDSL 327
              SV E++ V T+V  ++  D D   N   EY +     G    F I+P +G +K  ++L
Sbjct: 1484 QSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGA---FTIDPMSGTLKTSNTL 1540

Query: 328  NREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
            +RE  SQ+  +    D            RS T  + + V ++ND  PV
Sbjct: 1541 DREARSQHTFSAVARDCSIQG------SRSTTVIIKVYVTDVNDNDPV 1582



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 39/135 (28%), Positives = 61/135 (45%), Gaps = 10/135 (7%)

Query: 245  AIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNM-EYTIVG 303
            A   V V +   N+ +P    S +  SV E+   +  V +V  TD D   N + EY+I+ 
Sbjct: 1769 AYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILS 1828

Query: 304  GNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVT 363
            GN      F I+  +GVI     L+ E+ S Y + V+ TD         + + S T  + 
Sbjct: 1829 GN--QEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD-------KGMPRLSNTTVIK 1879

Query: 364  ISVLNMNDEPPVCNP 378
            + V ++ND  P   P
Sbjct: 1880 VQVTDINDNAPAFLP 1894



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 39/151 (25%), Positives = 64/151 (42%), Gaps = 34/151 (22%)

Query: 178  MFCLDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCD 237
            +F +DP TG I   Q L+ +N +    Y L  +A D G+ T+S    V +E +D      
Sbjct: 2369 LFLIDPLTGDIHAKQILDYENGNK---YCLTVQAKDKGDATASLVVWVDIEGID------ 2419

Query: 238  PSFSTGAAIITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNM 297
                                E  PI +   + F++ E +    L+G+V  +DAD   +  
Sbjct: 2420 --------------------EFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDG- 2458

Query: 298  EYTIVGGNLGT-PPKFYIEPDTGVIKLLDSL 327
               ++  +LGT  P F +    G I L+ +L
Sbjct: 2459 ---VILYSLGTSSPFFSVNKTNGNIYLIRAL 2486



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 44/155 (28%), Positives = 68/155 (43%), Gaps = 20/155 (12%)

Query: 268 FTFSVFENSPVDTLVGKVTFTDADWPFNNME---YTIVGGNLGTPPKFYIEPDTGVIKLL 324
           +TF V+E+ P D+ +G V    A  P N+ E   Y I  G+LG   KF I P  G I+  
Sbjct: 382 YTFLVYEDVPEDSPIGTV---KAREPLNSSEPIFYRISSGDLG--GKFSIHPRLGTIRTR 436

Query: 325 DSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPHLETQ 384
             L+ E +    + V        + P        + +V I+V+++ND  P       E +
Sbjct: 437 KPLDHETQ---PVVVLTVQAQLGSAP-----ACSSTEVNITVMDVNDNHPAFLRTSDEIR 488

Query: 385 IYSTV---ESFHSAQLFSKDSPQEHL-SYSIVGEQ 415
           I  T     + + A+   +DS +  L  YSI   Q
Sbjct: 489 ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ 523



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 67/283 (23%), Positives = 111/283 (39%), Gaps = 49/283 (17%)

Query: 143  NVTEKKSVGEIIARVKATDRDED-SSIIYSFKTQQKM--FCLDPFTGTITLLQPLNLDNP 199
            +V E   VG ++  + A D+DE  +     F T +    F +DP +GT            
Sbjct: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGT------------ 1533

Query: 200  SNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINEL 259
                   L+T  T +    S +TF+    +      C    S    +I + V V+ +N+ 
Sbjct: 1534 -------LKTSNTLDREARSQHTFSAVARD------CSIQGSRSTTVI-IKVYVTDVNDN 1579

Query: 260  NPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTG 319
            +P+   + F   +   SP +     V   D D   N    T+V     T   F I+  TG
Sbjct: 1580 DPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNG---TVVFSFAETQSMFSIDKYTG 1636

Query: 320  VIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPP 379
             I+   + + E    + + +KVTD        P R  +G     + V++M  E    +  
Sbjct: 1637 EIQFQQNPSSEYFPIW-LQLKVTDQG-----IPARTTTG-----LLVIHMEGEDVKISFS 1685

Query: 380  H-----LETQIYSTVESFHSAQLFSKDSPQEHLSYSIV-GEQD 416
            H     L T+      S  + + F+ DS Q+ + YSI  G +D
Sbjct: 1686 HHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNED 1728



 Score = 37.0 bits (84), Expect = 0.042
 Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 7/109 (6%)

Query: 284 KVTFTDADWP-FNNMEYTIVGGNLG--TPPKFYIEPDTGVIKLLDSLNREIE-SQYKIAV 339
           +VT +DAD   +  +EY++  G L    P  F I+P  G I +   ++RE + + Y + V
Sbjct: 78  EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137

Query: 340 KVTDLDNDAIPDPLRQRSGT---AQVTISVLNMNDEPPVCNPPHLETQI 385
           +  D D   +      + G    A V + + ++ND  PV NP    T I
Sbjct: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSI 186



 Score = 32.7 bits (73), Expect = 0.79
 Identities = 35/157 (22%), Positives = 65/157 (41%), Gaps = 27/157 (17%)

Query: 179 FCLDPFTGTITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDP 238
           F +DP  G I + Q  ++D   +   Y L  EA D      ++   V             
Sbjct: 109 FRIDPHDGQICVSQ--DIDRERDPATYDLLVEAKDGDEQRMTHLALV------------- 153

Query: 239 SFSTGAAIITVIVRVSR--INELNPIGSASAFTFSVFENSPVDTLVGKVTFTDAD-WPFN 295
               G       VRV    +N+ +P+ + S +  S+ + +   T +  V  TD D   + 
Sbjct: 154 ---KGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYG 210

Query: 296 NMEYTIVGGNLGTPPKFYIEPDTGV----IKLLDSLN 328
            + Y ++ GN+ +   F I+  TG+    +++L ++N
Sbjct: 211 TVAYELIPGNVSS--LFTIDSTTGLYSPEVEILSAVN 245


>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
          Length = 1237

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 72/239 (30%), Positives = 100/239 (41%), Gaps = 42/239 (17%)

Query: 146 EKKSVGEIIARVKATDRDEDSS--IIYSFKTQ---QKMFCLDPFTGTITLLQPLNLDNPS 200
           E    GE+IA + A+D D  S+  ++YS + +   + +F + P TG I +   L+ +   
Sbjct: 517 ENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRE 576

Query: 201 NSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELN 260
           +   Y L+  A D G+ +   T TV V NV D    DP F                    
Sbjct: 577 S---YELKVVAADRGSPSLQGTATVLV-NVLDCNDNDPKFML------------------ 614

Query: 261 PIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTGV 320
                S + FSV EN P  + VG VT  D D   N      V  + G    F I+  TG 
Sbjct: 615 -----SGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNG---DFVIQNGTGT 666

Query: 321 IKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPP 379
           I    S +RE +S Y   +K  D     +P     RS    VTI+VL+ ND  P    P
Sbjct: 667 ILSSLSFDREQQSTYTFQLKAVD---GGVP----PRSAYVGVTINVLDENDNAPYITAP 718



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 55/232 (23%), Positives = 97/232 (41%), Gaps = 24/232 (10%)

Query: 143 NVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNS 202
           N++E  +    +A V+ +DRDE  +   +        C+        L Q     + S  
Sbjct: 403 NISEDVAEETAVALVQVSDRDEGENAAVT--------CVVAGDVPFQLRQASETGSDSKK 454

Query: 203 KIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPI 262
           K Y L+T    +      YT  +   +  +P    P  ST +  + V+     +N+  P+
Sbjct: 455 K-YFLQTTTPLDYEKVKDYTIEIVAVDSGNP----PLSSTNSLKVQVV----DVNDNAPV 505

Query: 263 GSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTGVIK 322
            + S    +  EN+    ++ ++T +DAD   N      +         F I P+TG I+
Sbjct: 506 FTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQ 565

Query: 323 LLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
           +  SL+RE    Y++ V   D  + ++        GTA V ++VL+ ND  P
Sbjct: 566 VKTSLDREQRESYELKVVAADRGSPSL-------QGTATVLVNVLDCNDNDP 610



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 54/238 (22%), Positives = 101/238 (42%), Gaps = 24/238 (10%)

Query: 138 PLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLD 197
           P+ ++ + E  ++G +     A+DRD   + + S++ Q      + F   + + +     
Sbjct: 171 PVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFG--LQVAEDQEEK 228

Query: 198 NPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRIN 257
            P    + +L+ E  D      SY  T+ V++   P    P  S+    +TV+      N
Sbjct: 229 QPQLIVMGNLDRERWD------SYDLTIKVQDGGSP----PRASSALLRVTVL----DTN 274

Query: 258 ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIEP 316
           +  P     ++   + ENSP+   V +V   D+D   N  +EYT             ++ 
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDR 334

Query: 317 DTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
           +TG+I +   ++RE  S  + +V   D   +        +S  AQV ++V +MND  P
Sbjct: 335 NTGLITVQGPVDREDLSTLRFSVLAKDRGTNP-------KSARAQVVVTVKDMNDNAP 385



 Score = 33.9 bits (76), Expect = 0.35
 Identities = 37/161 (22%), Positives = 67/161 (41%), Gaps = 14/161 (8%)

Query: 251 VRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNM-EYTIVGGN---- 305
           + V  IN+  P  ++   T ++ EN+ + +L      +D D   N +  Y +  G     
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215

Query: 306 -LGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTI 364
             G       E     + ++ +L+RE    Y + +KV D  +         R+ +A + +
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPP-------RASSALLRV 268

Query: 365 SVLNMNDEPPVCNPPHLETQIYSTVESFHSA-QLFSKDSPQ 404
           +VL+ ND  P    P  E ++       HS  Q+ + DS Q
Sbjct: 269 TVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQ 309


>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
          Length = 1060

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 72/239 (30%), Positives = 100/239 (41%), Gaps = 42/239 (17%)

Query: 146 EKKSVGEIIARVKATDRDEDSS--IIYSFKTQ---QKMFCLDPFTGTITLLQPLNLDNPS 200
           E    GE+IA + A+D D  S+  ++YS + +   + +F + P TG I +   L+ +   
Sbjct: 517 ENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRE 576

Query: 201 NSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELN 260
           +   Y L+  A D G+ +   T TV V NV D    DP F                    
Sbjct: 577 S---YELKVVAADRGSPSLQGTATVLV-NVLDCNDNDPKFML------------------ 614

Query: 261 PIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTGV 320
                S + FSV EN P  + VG VT  D D   N      V  + G    F I+  TG 
Sbjct: 615 -----SGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNG---DFVIQNGTGT 666

Query: 321 IKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPP 379
           I    S +RE +S Y   +K  D     +P     RS    VTI+VL+ ND  P    P
Sbjct: 667 ILSSLSFDREQQSTYTFQLKAVD---GGVP----PRSAYVGVTINVLDENDNAPYITAP 718



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 55/232 (23%), Positives = 97/232 (41%), Gaps = 24/232 (10%)

Query: 143 NVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNS 202
           N++E  +    +A V+ +DRDE  +   +        C+        L Q     + S  
Sbjct: 403 NISEDVAEETAVALVQVSDRDEGENAAVT--------CVVAGDVPFQLRQASETGSDSKK 454

Query: 203 KIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPI 262
           K Y L+T    +      YT  +   +  +P    P  ST +  + V+     +N+  P+
Sbjct: 455 K-YFLQTTTPLDYEKVKDYTIEIVAVDSGNP----PLSSTNSLKVQVV----DVNDNAPV 505

Query: 263 GSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDTGVIK 322
            + S    +  EN+    ++ ++T +DAD   N      +         F I P+TG I+
Sbjct: 506 FTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQ 565

Query: 323 LLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
           +  SL+RE    Y++ V   D  + ++        GTA V ++VL+ ND  P
Sbjct: 566 VKTSLDREQRESYELKVVAADRGSPSL-------QGTATVLVNVLDCNDNDP 610



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 54/238 (22%), Positives = 101/238 (42%), Gaps = 24/238 (10%)

Query: 138 PLDSINVTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLD 197
           P+ ++ + E  ++G +     A+DRD   + + S++ Q      + F   + + +     
Sbjct: 171 PVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFG--LQVAEDQEEK 228

Query: 198 NPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRIN 257
            P    + +L+ E  D      SY  T+ V++   P    P  S+    +TV+      N
Sbjct: 229 QPQLIVMGNLDRERWD------SYDLTIKVQDGGSP----PRASSALLRVTVL----DTN 274

Query: 258 ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTPPKFYIEP 316
           +  P     ++   + ENSP+   V +V   D+D   N  +EYT             ++ 
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDR 334

Query: 317 DTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
           +TG+I +   ++RE  S  + +V   D   +        +S  AQV ++V +MND  P
Sbjct: 335 NTGLITVQGPVDREDLSTLRFSVLAKDRGTNP-------KSARAQVVVTVKDMNDNAP 385



 Score = 33.9 bits (76), Expect = 0.35
 Identities = 37/161 (22%), Positives = 67/161 (41%), Gaps = 14/161 (8%)

Query: 251 VRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNM-EYTIVGGN---- 305
           + V  IN+  P  ++   T ++ EN+ + +L      +D D   N +  Y +  G     
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215

Query: 306 -LGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTI 364
             G       E     + ++ +L+RE    Y + +KV D  +         R+ +A + +
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPP-------RASSALLRV 268

Query: 365 SVLNMNDEPPVCNPPHLETQIYSTVESFHSA-QLFSKDSPQ 404
           +VL+ ND  P    P  E ++       HS  Q+ + DS Q
Sbjct: 269 TVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQ 309


>gi|116534898 desmoglein 2 preproprotein [Homo sapiens]
          Length = 1118

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 49/139 (35%), Positives = 70/139 (50%), Gaps = 8/139 (5%)

Query: 251 VRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWP---FNNMEYTIVGGNLG 307
           ++V  IN+  P+ +   F  SV E S   TLV K+  TDAD P    + + Y IV     
Sbjct: 147 IKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPA 206

Query: 308 TPPKFYIEPDTGVIKLLD-SLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISV 366
            PP FY+  DTG I     +L+RE  S Y + V+  D + +    P++Q    AQV I +
Sbjct: 207 YPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQ----AQVQIRI 262

Query: 367 LNMNDEPPVCNPPHLETQI 385
           L++ND  PV     LE  +
Sbjct: 263 LDVNDNIPVVENKVLEGMV 281


>gi|16507964 cadherin-like 23 isoform 2 precursor [Homo sapiens]
          Length = 530

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 66/264 (25%), Positives = 117/264 (44%), Gaps = 37/264 (14%)

Query: 141 SINVTEKKSVGEIIARVKATDRD--EDSSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDN 198
           S+ + E   VG  I  V ATD D     S++YSF+   + F +D   G +T+++ L+ + 
Sbjct: 138 SVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYE- 196

Query: 199 PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
              ++ Y L   ATD              ++   P+S          +  + + ++ + +
Sbjct: 197 --TTQAYQLTVNATD--------------QDKTRPLS---------TLANLAIIITDVQD 231

Query: 259 LNPIGSASAFTFSVFENSPVDTLVGKVTFTDAD-WPFNNMEYTIVGGNLGTPPKFYIEPD 317
           ++PI     ++ +++E+SP  T V  +T  D D      + YTIV GN  T   F ++  
Sbjct: 232 MDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGN--TNSIFALDYI 289

Query: 318 TGVIKLLDSLNRE---IESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPP 374
           +GV+ L   L+RE       + + VK T+L++D  P      + T    I V+++ND  P
Sbjct: 290 SGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS---DATVTTTFNILVIDINDNAP 346

Query: 375 VCNPPHLETQIYSTVESFHSAQLF 398
             N       I    +   +  LF
Sbjct: 347 EFNSSEYSVAITELAQVGFALPLF 370



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 56/249 (22%), Positives = 98/249 (39%), Gaps = 50/249 (20%)

Query: 144 VTEKKSVGEIIARVKATDRDEDSSII-YSFKTQQKMFCLDPFTGTITLLQPLNLDNPSNS 202
           ++E   VG  + ++ A D D D  +   S +   + F ++P TG + L QPL+ +  S  
Sbjct: 42  ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSE- 100

Query: 203 KIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINELNPI 262
             +++E   +D+                            G     V ++V  +N+  P 
Sbjct: 101 --FTVEFSVSDH---------------------------QGVITRKVNIQVGDVNDNAPT 131

Query: 263 GSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNL---GTPPK--FYIEPD 317
                ++  + EN+PV T +  V  TD D           GG++     PP   F I+  
Sbjct: 132 FHNQPYSVRIPENTPVGTPIFIVNATDPDLG--------AGGSVLYSFQPPSQFFAIDSA 183

Query: 318 TGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCN 377
            G++ ++  L+ E    Y++ V  TD       D  R  S  A + I + ++ D  P+  
Sbjct: 184 RGIVTVIRELDYETTQAYQLTVNATD------QDKTRPLSTLANLAIIITDVQDMDPIFI 237

Query: 378 PPHLETQIY 386
                T IY
Sbjct: 238 NLPYSTNIY 246



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 35/118 (29%), Positives = 53/118 (44%), Gaps = 23/118 (19%)

Query: 272 VFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPK--FYIEPDTGVIKLLDSLNR 329
           + E++PV + V ++   D D         +V G  G      F +EPDTGV+ L   L+R
Sbjct: 42  ISEDTPVGSSVTQLLAQDMD------NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDR 95

Query: 330 EIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNPPHLETQIYS 387
           E +S++ +   V+D           Q   T +V I V ++ND     N P    Q YS
Sbjct: 96  ETKSEFTVEFSVSD----------HQGVITRKVNIQVGDVND-----NAPTFHNQPYS 138


>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
          Length = 788

 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 42/126 (33%), Positives = 67/126 (53%), Gaps = 6/126 (4%)

Query: 250 IVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTP 309
           ++++  IN+  P      +T SV E S V T V +VT TDAD P       ++   L   
Sbjct: 147 VIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQ 206

Query: 310 PKFYIEPDTGVIK-LLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLN 368
           P F +EP+TG+I+  L ++NRE   QY++ ++  D+        +   SGT  V I++ +
Sbjct: 207 PYFSVEPETGIIRTALPNMNRENREQYQVVIQAKDMGGQ-----MGGLSGTTTVNITLTD 261

Query: 369 MNDEPP 374
           +ND PP
Sbjct: 262 VNDNPP 267



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 71/263 (26%), Positives = 110/263 (41%), Gaps = 33/263 (12%)

Query: 136 PFPLDSINVTEKKSVGEIIARVKATDRDEDS-----SIIYSFKTQQKMFCLDPFTGTITL 190
           P  + + +V E   VG  + +V ATD D+ S      +IYS    Q  F ++P TG I  
Sbjct: 161 PEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGIIRT 220

Query: 191 LQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVI 250
             P N+ N  N + Y +  +A D G      + T                       TV 
Sbjct: 221 ALP-NM-NRENREQYQVVIQAKDMGGQMGGLSGTT----------------------TVN 256

Query: 251 VRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN-NMEYTIVGGNLGTP 309
           + ++ +N+  P    +     V E+SPV T +G V  TDAD   N  +EY I+ G+    
Sbjct: 257 ITLTDVNDNPPRFPQNTIHLRVLESSPVGTAIGSVKATDADTGKNAEVEYRIIDGDGTDM 316

Query: 310 PKFYIEPDT--GVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVL 367
                E DT  G+I +   L+ E    Y + V+  +   D     L     T  V IS+ 
Sbjct: 317 FDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIE 376

Query: 368 NMNDEPPVCNPPHLETQIYSTVE 390
           ++ DEPPV +      +++  +E
Sbjct: 377 DV-DEPPVFSRSSYLFEVHEDIE 398



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 58/250 (23%), Positives = 108/250 (43%), Gaps = 43/250 (17%)

Query: 137 FPLDSIN--VTEKKSVGEIIARVKATDRDEDSSIIYSFKTQQ----KMFCL----DPFTG 186
           FP ++I+  V E   VG  I  VKATD D   +    ++        MF +    D   G
Sbjct: 269 FPQNTIHLRVLESSPVGTAIGSVKATDADTGKNAEVEYRIIDGDGTDMFDIVTEKDTQEG 328

Query: 187 TITLLQPLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAI 246
            IT+ +PL+ ++    ++Y+L+ EA +   +   Y    F +                  
Sbjct: 329 IITVKKPLDYES---RRLYTLKVEAENTHVDPRFYYLGPFKD------------------ 367

Query: 247 ITVIVRVSRINELN--PIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGG 304
            T IV++S I +++  P+ S S++ F V E+  V T++G V   D D   + + +++   
Sbjct: 368 -TTIVKIS-IEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSISSPIRFSL-DR 424

Query: 305 NLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTI 364
           +      F I    G +     L+RE+   + + V   +++N        + +    V +
Sbjct: 425 HTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINNP-------KETTRVAVFV 477

Query: 365 SVLNMNDEPP 374
            +L++ND  P
Sbjct: 478 RILDVNDNAP 487


>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
          Length = 1340

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 76/283 (26%), Positives = 120/283 (42%), Gaps = 47/283 (16%)

Query: 141 SINVTEKKSVGEIIARVKATDRDEDSSIIYSF---KTQQKMFCLDPFTGTITLLQPLNLD 197
           ++++ E  S G  + +V ATD D   +   ++         F LD  TG +T+++ L+ +
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563

Query: 198 NPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRIN 257
                  Y     A DNG    +   TVFV  +D                         N
Sbjct: 564 KEDK---YLFTILAKDNGVPPLTSNVTVFVSIIDQ------------------------N 596

Query: 258 ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPD 317
           + +P+ + + + F V EN P    VG +T TD D+  N+    +    L     F I+  
Sbjct: 597 DNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNS---AVTLSILDENDDFTIDSQ 653

Query: 318 TGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV-C 376
           TGVI+   S +RE +  Y   VK  D    +       RS +A+VTI+V+++ND  PV  
Sbjct: 654 TGVIRPNISFDREKQESYTFYVKAEDGGRVS-------RSSSAKVTINVVDVNDNKPVFI 706

Query: 377 NPPH---LETQIYSTVESFHSAQLFSKDSP---QEHLSYSIVG 413
            PP+    E  + ST       Q+ + D+       + YSIVG
Sbjct: 707 VPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG 749



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 59/248 (23%), Positives = 110/248 (44%), Gaps = 36/248 (14%)

Query: 140 DSINVTEKKSVGEIIARVKATDRDED-SSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDN 198
           D++ ++E   +   IA +  TD+D D +  +  F   +  F L P      LL+     +
Sbjct: 398 DTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLD 457

Query: 199 PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
             ++K Y+++  A D G    + +  +F++  D+                        N+
Sbjct: 458 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDE------------------------ND 493

Query: 259 LNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDT 318
             P+ + S  T S+ EN+     + KV+ TDAD   N     ++G +   PP+F ++  T
Sbjct: 494 NAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPD--APPEFSLDRRT 551

Query: 319 GVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNP 378
           G++ ++  L+RE E +Y   +   D   + +P PL   +    V +S+++ ND  PV   
Sbjct: 552 GMLTVVKKLDREKEDKYLFTILAKD---NGVP-PL---TSNVTVFVSIIDQNDNSPVFT- 603

Query: 379 PHLETQIY 386
            H E + Y
Sbjct: 604 -HNEYKFY 610



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 57/260 (21%), Positives = 108/260 (41%), Gaps = 37/260 (14%)

Query: 137 FPLDSINVT--EKKSVGEIIARVKATDRDEDSSIIYSFKT--QQKMFCLDPFTGTITLLQ 192
           FP   IN++  E  ++        A D D   + + +++    Q +F LD          
Sbjct: 171 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDV--------- 221

Query: 193 PLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVR 252
              ++ P   K+  L  +   +     +Y   V VE        D  F   ++   + V 
Sbjct: 222 ---IETPEGDKMPQLIVQKELDREEKDTYVMKVKVE--------DGGFPQRSSTAILQVS 270

Query: 253 VSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN---NMEYTIVGGNLGTP 309
           V+  N+ +P+   +    S+ EN+PV T V ++  TDAD   N   +  ++ +  N+   
Sbjct: 271 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR- 329

Query: 310 PKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNM 369
             F++   TG+I + + L+RE    +K+ V  +  D   +P         A V ++V ++
Sbjct: 330 RLFHLNATTGLITIKEPLDREETPNHKLLVLAS--DGGLMP-------ARAMVLVNVTDV 380

Query: 370 NDEPPVCNPPHLETQIYSTV 389
           ND  P  +  ++   +  TV
Sbjct: 381 NDNVPSIDIRYIVNPVNDTV 400



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 44/178 (24%), Positives = 73/178 (41%), Gaps = 23/178 (12%)

Query: 246 IITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNME------- 298
           ++ +   +  IN+  P+  A+    S+ ENS +++        D D   N ++       
Sbjct: 154 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 213

Query: 299 YTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSG 358
             I G ++   P+    P   V K LD   RE +  Y + VKV D           QRS 
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELD---REEKDTYVMKVKVED-------GGFPQRSS 263

Query: 359 TAQVTISVLNMNDEPPVCNPPHLETQI------YSTVESFHSAQLFSKDSPQEHLSYS 410
           TA + +SV + ND  PV     +E  I       ++V   H+      ++ + H S+S
Sbjct: 264 TAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS 321


>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
          Length = 1048

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 76/283 (26%), Positives = 120/283 (42%), Gaps = 47/283 (16%)

Query: 141 SINVTEKKSVGEIIARVKATDRDEDSSIIYSF---KTQQKMFCLDPFTGTITLLQPLNLD 197
           ++++ E  S G  + +V ATD D   +   ++         F LD  TG +T+++ L+ +
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563

Query: 198 NPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRIN 257
                  Y     A DNG    +   TVFV  +D                         N
Sbjct: 564 KEDK---YLFTILAKDNGVPPLTSNVTVFVSIIDQ------------------------N 596

Query: 258 ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPD 317
           + +P+ + + + F V EN P    VG +T TD D+  N+    +    L     F I+  
Sbjct: 597 DNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNS---AVTLSILDENDDFTIDSQ 653

Query: 318 TGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV-C 376
           TGVI+   S +RE +  Y   VK  D    +       RS +A+VTI+V+++ND  PV  
Sbjct: 654 TGVIRPNISFDREKQESYTFYVKAEDGGRVS-------RSSSAKVTINVVDVNDNKPVFI 706

Query: 377 NPPH---LETQIYSTVESFHSAQLFSKDSP---QEHLSYSIVG 413
            PP+    E  + ST       Q+ + D+       + YSIVG
Sbjct: 707 VPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG 749



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 59/248 (23%), Positives = 110/248 (44%), Gaps = 36/248 (14%)

Query: 140 DSINVTEKKSVGEIIARVKATDRDED-SSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDN 198
           D++ ++E   +   IA +  TD+D D +  +  F   +  F L P      LL+     +
Sbjct: 398 DTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLD 457

Query: 199 PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
             ++K Y+++  A D G    + +  +F++  D+                        N+
Sbjct: 458 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDE------------------------ND 493

Query: 259 LNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDT 318
             P+ + S  T S+ EN+     + KV+ TDAD   N     ++G +   PP+F ++  T
Sbjct: 494 NAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPD--APPEFSLDRRT 551

Query: 319 GVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNP 378
           G++ ++  L+RE E +Y   +   D   + +P PL   +    V +S+++ ND  PV   
Sbjct: 552 GMLTVVKKLDREKEDKYLFTILAKD---NGVP-PL---TSNVTVFVSIIDQNDNSPVFT- 603

Query: 379 PHLETQIY 386
            H E + Y
Sbjct: 604 -HNEYKFY 610



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 57/260 (21%), Positives = 108/260 (41%), Gaps = 37/260 (14%)

Query: 137 FPLDSINVT--EKKSVGEIIARVKATDRDEDSSIIYSFKT--QQKMFCLDPFTGTITLLQ 192
           FP   IN++  E  ++        A D D   + + +++    Q +F LD          
Sbjct: 171 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDV--------- 221

Query: 193 PLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVR 252
              ++ P   K+  L  +   +     +Y   V VE        D  F   ++   + V 
Sbjct: 222 ---IETPEGDKMPQLIVQKELDREEKDTYVMKVKVE--------DGGFPQRSSTAILQVS 270

Query: 253 VSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN---NMEYTIVGGNLGTP 309
           V+  N+ +P+   +    S+ EN+PV T V ++  TDAD   N   +  ++ +  N+   
Sbjct: 271 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR- 329

Query: 310 PKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNM 369
             F++   TG+I + + L+RE    +K+ V  +  D   +P         A V ++V ++
Sbjct: 330 RLFHLNATTGLITIKEPLDREETPNHKLLVLAS--DGGLMP-------ARAMVLVNVTDV 380

Query: 370 NDEPPVCNPPHLETQIYSTV 389
           ND  P  +  ++   +  TV
Sbjct: 381 NDNVPSIDIRYIVNPVNDTV 400



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 44/178 (24%), Positives = 73/178 (41%), Gaps = 23/178 (12%)

Query: 246 IITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNME------- 298
           ++ +   +  IN+  P+  A+    S+ ENS +++        D D   N ++       
Sbjct: 154 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 213

Query: 299 YTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSG 358
             I G ++   P+    P   V K LD   RE +  Y + VKV D           QRS 
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELD---REEKDTYVMKVKVED-------GGFPQRSS 263

Query: 359 TAQVTISVLNMNDEPPVCNPPHLETQI------YSTVESFHSAQLFSKDSPQEHLSYS 410
           TA + +SV + ND  PV     +E  I       ++V   H+      ++ + H S+S
Sbjct: 264 TAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS 321


>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
          Length = 1037

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 76/283 (26%), Positives = 120/283 (42%), Gaps = 47/283 (16%)

Query: 141 SINVTEKKSVGEIIARVKATDRDEDSSIIYSF---KTQQKMFCLDPFTGTITLLQPLNLD 197
           ++++ E  S G  + +V ATD D   +   ++         F LD  TG +T+++ L+ +
Sbjct: 493 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 552

Query: 198 NPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRIN 257
                  Y     A DNG    +   TVFV  +D                         N
Sbjct: 553 KEDK---YLFTILAKDNGVPPLTSNVTVFVSIIDQ------------------------N 585

Query: 258 ELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPD 317
           + +P+ + + + F V EN P    VG +T TD D+  N+    +    L     F I+  
Sbjct: 586 DNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNS---AVTLSILDENDDFTIDSQ 642

Query: 318 TGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV-C 376
           TGVI+   S +RE +  Y   VK  D    +       RS +A+VTI+V+++ND  PV  
Sbjct: 643 TGVIRPNISFDREKQESYTFYVKAEDGGRVS-------RSSSAKVTINVVDVNDNKPVFI 695

Query: 377 NPPH---LETQIYSTVESFHSAQLFSKDSP---QEHLSYSIVG 413
            PP+    E  + ST       Q+ + D+       + YSIVG
Sbjct: 696 VPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG 738



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 59/248 (23%), Positives = 110/248 (44%), Gaps = 36/248 (14%)

Query: 140 DSINVTEKKSVGEIIARVKATDRDED-SSIIYSFKTQQKMFCLDPFTGTITLLQPLNLDN 198
           D++ ++E   +   IA +  TD+D D +  +  F   +  F L P      LL+     +
Sbjct: 387 DTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLD 446

Query: 199 PSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVRVSRINE 258
             ++K Y+++  A D G    + +  +F++  D+                        N+
Sbjct: 447 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDE------------------------ND 482

Query: 259 LNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIEPDT 318
             P+ + S  T S+ EN+     + KV+ TDAD   N     ++G +   PP+F ++  T
Sbjct: 483 NAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPD--APPEFSLDRRT 540

Query: 319 GVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPVCNP 378
           G++ ++  L+RE E +Y   +   D   + +P PL   +    V +S+++ ND  PV   
Sbjct: 541 GMLTVVKKLDREKEDKYLFTILAKD---NGVP-PL---TSNVTVFVSIIDQNDNSPVFT- 592

Query: 379 PHLETQIY 386
            H E + Y
Sbjct: 593 -HNEYKFY 599



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 57/260 (21%), Positives = 108/260 (41%), Gaps = 37/260 (14%)

Query: 137 FPLDSINVT--EKKSVGEIIARVKATDRDEDSSIIYSFKT--QQKMFCLDPFTGTITLLQ 192
           FP   IN++  E  ++        A D D   + + +++    Q +F LD          
Sbjct: 160 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDV--------- 210

Query: 193 PLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVR 252
              ++ P   K+  L  +   +     +Y   V VE        D  F   ++   + V 
Sbjct: 211 ---IETPEGDKMPQLIVQKELDREEKDTYVMKVKVE--------DGGFPQRSSTAILQVS 259

Query: 253 VSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN---NMEYTIVGGNLGTP 309
           V+  N+ +P+   +    S+ EN+PV T V ++  TDAD   N   +  ++ +  N+   
Sbjct: 260 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR- 318

Query: 310 PKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNM 369
             F++   TG+I + + L+RE    +K+ V  +  D   +P         A V ++V ++
Sbjct: 319 RLFHLNATTGLITIKEPLDREETPNHKLLVLAS--DGGLMP-------ARAMVLVNVTDV 369

Query: 370 NDEPPVCNPPHLETQIYSTV 389
           ND  P  +  ++   +  TV
Sbjct: 370 NDNVPSIDIRYIVNPVNDTV 389



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 44/178 (24%), Positives = 73/178 (41%), Gaps = 23/178 (12%)

Query: 246 IITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNME------- 298
           ++ +   +  IN+  P+  A+    S+ ENS +++        D D   N ++       
Sbjct: 143 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 202

Query: 299 YTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSG 358
             I G ++   P+    P   V K LD   RE +  Y + VKV D           QRS 
Sbjct: 203 QNIFGLDVIETPEGDKMPQLIVQKELD---REEKDTYVMKVKVED-------GGFPQRSS 252

Query: 359 TAQVTISVLNMNDEPPVCNPPHLETQI------YSTVESFHSAQLFSKDSPQEHLSYS 410
           TA + +SV + ND  PV     +E  I       ++V   H+      ++ + H S+S
Sbjct: 253 TAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS 310


>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
           sapiens]
          Length = 1021

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 108/465 (23%), Positives = 192/465 (41%), Gaps = 65/465 (13%)

Query: 3   MGSKLKCEHDTNGKVEPHAADNHFQGAGLGPN------QIMAGSGVITATKIFNYETDPI 56
           +G+ +   H T+  +  +A   HF  + L  N       + A +G+IT  +  + E  P 
Sbjct: 264 VGTSVTQLHATDADIGENAKI-HFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPN 322

Query: 57  RFLLIV--DTGRL-YRHVLTINIIDVPES-PNCTADPKFSSGTATLEIDEDYPLFQSIYR 112
             LL++  D G +  R ++ +N+ DV ++ P+       +    T+ + E+ PL   I  
Sbjct: 323 HKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIAL 382

Query: 113 VTATDEVFANGDRLNVGGDH---------CARPFPLDSINVTEKKSVGEIIARVKATDRD 163
           +T TD+   +  R+    DH          +  F L++    + +S  E   ++ A D  
Sbjct: 383 ITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAG 442

Query: 164 E---DSSIIYSFKTQQKMFCLDPFTGT---------------ITLLQPLNLDNPSNSKI- 204
           +   + S +   K + +      FT +               +T +  ++ D+  N+KI 
Sbjct: 443 KPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKIN 502

Query: 205 YSLETEATDNGNNTSSYTFTVFVENVDDP---------ISCDPSFSTGAAIITVIVRVSR 255
           Y L  +A    +          V+ +D           ++ D       + +TV V +  
Sbjct: 503 YLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIID 562

Query: 256 INELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNMEYTIVGGNLGTPPKFYIE 315
            N+ +P+ + + + F V EN P    VG +T TD D+  N+    +    L     F I+
Sbjct: 563 QNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS---AVTLSILDENDDFTID 619

Query: 316 PDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNMNDEPPV 375
             TGVI+   S +RE +  Y   VK  D    +       RS +A+VTI+V+++ND  PV
Sbjct: 620 SQTGVIRPNISFDREKQESYTFYVKAEDGGRVS-------RSSSAKVTINVVDVNDNKPV 672

Query: 376 CNPP----HLETQIYSTVESFHSAQLFSKDSP---QEHLSYSIVG 413
              P      E  + ST       Q+ + D+       + YSIVG
Sbjct: 673 FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG 717



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 57/260 (21%), Positives = 108/260 (41%), Gaps = 37/260 (14%)

Query: 137 FPLDSINVT--EKKSVGEIIARVKATDRDEDSSIIYSFKT--QQKMFCLDPFTGTITLLQ 192
           FP   IN++  E  ++        A D D   + + +++    Q +F LD          
Sbjct: 139 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDV--------- 189

Query: 193 PLNLDNPSNSKIYSLETEATDNGNNTSSYTFTVFVENVDDPISCDPSFSTGAAIITVIVR 252
              ++ P   K+  L  +   +     +Y   V VE        D  F   ++   + V 
Sbjct: 190 ---IETPEGDKMPQLIVQKELDREEKDTYVMKVKVE--------DGGFPQRSSTAILQVS 238

Query: 253 VSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFN---NMEYTIVGGNLGTP 309
           V+  N+ +P+   +    S+ EN+PV T V ++  TDAD   N   +  ++ +  N+   
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR- 297

Query: 310 PKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSGTAQVTISVLNM 369
             F++   TG+I + + L+RE    +K+ V  +  D   +P         A V ++V ++
Sbjct: 298 RLFHLNATTGLITIKEPLDREETPNHKLLVLAS--DGGLMP-------ARAMVLVNVTDV 348

Query: 370 NDEPPVCNPPHLETQIYSTV 389
           ND  P  +  ++   +  TV
Sbjct: 349 NDNVPSIDIRYIVNPVNDTV 368



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 44/178 (24%), Positives = 73/178 (41%), Gaps = 23/178 (12%)

Query: 246 IITVIVRVSRINELNPIGSASAFTFSVFENSPVDTLVGKVTFTDADWPFNNME------- 298
           ++ +   +  IN+  P+  A+    S+ ENS +++        D D   N ++       
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKS 181

Query: 299 YTIVGGNLGTPPKFYIEPDTGVIKLLDSLNREIESQYKIAVKVTDLDNDAIPDPLRQRSG 358
             I G ++   P+    P   V K LD   RE +  Y + VKV D           QRS 
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELD---REEKDTYVMKVKVED-------GGFPQRSS 231

Query: 359 TAQVTISVLNMNDEPPVCNPPHLETQI------YSTVESFHSAQLFSKDSPQEHLSYS 410
           TA + +SV + ND  PV     +E  I       ++V   H+      ++ + H S+S
Sbjct: 232 TAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS 289


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,365,569
Number of Sequences: 37866
Number of extensions: 863542
Number of successful extensions: 2843
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 110
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 1422
Number of HSP's gapped (non-prelim): 962
length of query: 503
length of database: 18,247,518
effective HSP length: 107
effective length of query: 396
effective length of database: 14,195,856
effective search space: 5621558976
effective search space used: 5621558976
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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