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Search of human proteins with 16753221
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16753221 cadherin 22 precursor [Homo sapiens]
(828 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16753221 cadherin 22 precursor [Homo sapiens] 1654 0.0
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens] 866 0.0
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens] 866 0.0
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 832 0.0
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens] 804 0.0
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens] 802 0.0
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens] 801 0.0
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 798 0.0
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens] 788 0.0
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 785 0.0
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens] 782 0.0
gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens] 674 0.0
gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens] 655 0.0
gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens] 646 0.0
gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens] 464 e-130
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens] 372 e-103
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens] 357 3e-98
gi|4826669 cadherin 15 preproprotein [Homo sapiens] 328 1e-89
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens] 303 4e-82
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens] 283 5e-76
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap... 234 2e-61
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap... 232 9e-61
gi|4502719 cadherin 13 preproprotein [Homo sapiens] 231 2e-60
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens] 218 2e-56
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi... 218 2e-56
gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo sapi... 207 3e-53
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 206 7e-53
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 206 9e-53
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi... 204 4e-52
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 190 5e-48
>gi|16753221 cadherin 22 precursor [Homo sapiens]
Length = 828
Score = 1654 bits (4283), Expect = 0.0
Identities = 828/828 (100%), Positives = 828/828 (100%)
Query: 1 MRPRPEGRGLRAGVALSPALLLLLLLPPPPTLLGRLWAAGTPSPSAPGARQDGALGAGRV 60
MRPRPEGRGLRAGVALSPALLLLLLLPPPPTLLGRLWAAGTPSPSAPGARQDGALGAGRV
Sbjct: 1 MRPRPEGRGLRAGVALSPALLLLLLLPPPPTLLGRLWAAGTPSPSAPGARQDGALGAGRV 60
Query: 61 KRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIH 120
KRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIH
Sbjct: 61 KRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIH 120
Query: 121 AMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAEL 180
AMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAEL
Sbjct: 121 AMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAEL 180
Query: 181 SPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQER 240
SPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQER
Sbjct: 181 SPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQER 240
Query: 241 YEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVK 300
YEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVK
Sbjct: 241 YEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVK 300
Query: 301 AEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEA 360
AEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEA
Sbjct: 301 AEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEA 360
Query: 361 LNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARD 420
LNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARD
Sbjct: 361 LNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARD 420
Query: 421 PDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQL 480
PDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQL
Sbjct: 421 PDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQL 480
Query: 481 SRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVP 540
SRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVP
Sbjct: 481 SRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVP 540
Query: 541 EAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRIC 600
EAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRIC
Sbjct: 541 EAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRIC 600
Query: 601 GCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDED 660
GCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDED
Sbjct: 601 GCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDED 660
Query: 661 EDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGS 720
EDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGS
Sbjct: 661 EDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGS 720
Query: 721 PPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADS 780
PPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADS
Sbjct: 721 PPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADS 780
Query: 781 PAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGHRGDDEAQAS 828
PAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGHRGDDEAQAS
Sbjct: 781 PAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGHRGDDEAQAS 828
>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 866 bits (2237), Expect = 0.0
Identities = 423/761 (55%), Positives = 558/761 (73%), Gaps = 25/761 (3%)
Query: 56 GAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDEL 115
G R KR WVWNQFFV+EEY G++PLYVGK+HSD D+GDG+IKY +SGEGA +IF+IDE
Sbjct: 41 GRSRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDEN 100
Query: 116 TGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIG 175
TGDIHA +RLDRE++ +YTLRAQA DR TN+ +EPESEF+IK+QDIND+EP+FL GPY
Sbjct: 101 TGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTA 160
Query: 176 SVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDR 235
V E+SP GTSV+QV A+DADDPTYG+SAR+VYS+L G+ +F+V+PKTGVI+TA+P++DR
Sbjct: 161 GVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDR 220
Query: 236 ESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTA 295
E++++Y +VIQA DM GQ GGLSG+T+VT+ +TDVNDNPPRFP++ YQ+++ ES P+ +
Sbjct: 221 EAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASV 280
Query: 296 VGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHT 355
V R+KA D+D+G N +M Y + D G +FK++ D +TQE II +QK LDFE++ +T
Sbjct: 281 VARIKAADADIGANAEMEYKIVDGDGLG--IFKISVDKETQEGIITIQKELDFEAKTSYT 338
Query: 356 VILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGV 415
+ +EA NK DPRF LG F D V++ V DVDEPP F P +EV E QVG+++G
Sbjct: 339 LRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGT 398
Query: 416 VTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEAD 475
V A DPD++N PVRY+IDR +DL++ F+IDA++G I T K LDRET HNITVLAME+
Sbjct: 399 VAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQ 458
Query: 476 NHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFY 535
N +Q+ R + I ILD+NDN PE A YE VCE+A+PGQ+IQ IS VD+DEP GH+FY
Sbjct: 459 NPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFY 518
Query: 536 FRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTL 595
F L +A +N +FSL D +DNTA++ T+ GF RQEQ V++LPI +VDSG P+LSST TL
Sbjct: 519 FSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTL 578
Query: 596 TIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHL 655
TIR+C CD+ G Q+CN A+V+ A LS GALIA+L CVL L+VL+LLI+T+RR K L
Sbjct: 579 TIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPL 638
Query: 656 SSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSG 715
DE+ D+R+N+++Y+DEGGGE+DTEA+DM+ALR+L + K
Sbjct: 639 IFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTK----------------- 681
Query: 716 GGAGSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAF 775
+ + E L + PD +FR+FI ++ AD D PPYD+ QTYAF
Sbjct: 682 ------TRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAF 735
Query: 776 EGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALY 816
EG S A SLSSL S SS S+Q++ YLS WGPRF+ LA +Y
Sbjct: 736 EGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMY 776
>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 866 bits (2237), Expect = 0.0
Identities = 423/761 (55%), Positives = 558/761 (73%), Gaps = 25/761 (3%)
Query: 56 GAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDEL 115
G R KR WVWNQFFV+EEY G++PLYVGK+HSD D+GDG+IKY +SGEGA +IF+IDE
Sbjct: 41 GRSRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDEN 100
Query: 116 TGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIG 175
TGDIHA +RLDRE++ +YTLRAQA DR TN+ +EPESEF+IK+QDIND+EP+FL GPY
Sbjct: 101 TGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTA 160
Query: 176 SVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDR 235
V E+SP GTSV+QV A+DADDPTYG+SAR+VYS+L G+ +F+V+PKTGVI+TA+P++DR
Sbjct: 161 GVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDR 220
Query: 236 ESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTA 295
E++++Y +VIQA DM GQ GGLSG+T+VT+ +TDVNDNPPRFP++ YQ+++ ES P+ +
Sbjct: 221 EAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASV 280
Query: 296 VGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHT 355
V R+KA D+D+G N +M Y + D G +FK++ D +TQE II +QK LDFE++ +T
Sbjct: 281 VARIKAADADIGANAEMEYKIVDGDGLG--IFKISVDKETQEGIITIQKELDFEAKTSYT 338
Query: 356 VILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGV 415
+ +EA NK DPRF LG F D V++ V DVDEPP F P +EV E QVG+++G
Sbjct: 339 LRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGT 398
Query: 416 VTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEAD 475
V A DPD++N PVRY+IDR +DL++ F+IDA++G I T K LDRET HNITVLAME+
Sbjct: 399 VAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQ 458
Query: 476 NHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFY 535
N +Q+ R + I ILD+NDN PE A YE VCE+A+PGQ+IQ IS VD+DEP GH+FY
Sbjct: 459 NPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFY 518
Query: 536 FRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTL 595
F L +A +N +FSL D +DNTA++ T+ GF RQEQ V++LPI +VDSG P+LSST TL
Sbjct: 519 FSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTL 578
Query: 596 TIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHL 655
TIR+C CD+ G Q+CN A+V+ A LS GALIA+L CVL L+VL+LLI+T+RR K L
Sbjct: 579 TIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPL 638
Query: 656 SSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSG 715
DE+ D+R+N+++Y+DEGGGE+DTEA+DM+ALR+L + K
Sbjct: 639 IFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTK----------------- 681
Query: 716 GGAGSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAF 775
+ + E L + PD +FR+FI ++ AD D PPYD+ QTYAF
Sbjct: 682 ------TRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAF 735
Query: 776 EGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALY 816
EG S A SLSSL S SS S+Q++ YLS WGPRF+ LA +Y
Sbjct: 736 EGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMY 776
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 832 bits (2150), Expect = 0.0
Identities = 416/781 (53%), Positives = 544/781 (69%), Gaps = 22/781 (2%)
Query: 41 TPSPSAPGARQDGALGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYT 100
TP D R KR WVWNQFFV+EEYTGT+PLYVGK+HSD D GDG+IKY
Sbjct: 38 TPQGELEALLSDKPQSHQRTKRSWVWNQFFVLEEYTGTDPLYVGKLHSDMDRGDGSIKYI 97
Query: 101 ISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQD 160
+SGEGAG +F ID+ TGDIHA++RLDRE++ YTLRAQA DR T R +EPESEFIIK+QD
Sbjct: 98 LSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQD 157
Query: 161 INDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVD 220
IND+EP+FL GPY+ +V E+SP GTSV+QV A+DADDPTYG+SAR+VYS+L G+ +F+VD
Sbjct: 158 INDNEPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQPYFSVD 217
Query: 221 PKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQK 280
KTGVIRTA+ ++DRE++E YEV+IQA DM GQLGGL+G+TTV I ++DVNDNPPRFPQK
Sbjct: 218 SKTGVIRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQK 277
Query: 281 MYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAII 340
YQ S+ ESAPI + VGRV A+D D G N +M Y + D G D F ++TD + Q II
Sbjct: 278 HYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVD--GDGADAFDISTDPNFQVGII 335
Query: 341 VVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGL 400
V+K L FES+ +T+ +E N ++ RF +LG F+D V ++V DVDEPP F P
Sbjct: 336 TVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDVDEPPVFEPGFYF 395
Query: 401 LEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRE 460
+EV ED +G+ + +++A+DPD N +RY+IDR SD + F +D TGA++T + LDRE
Sbjct: 396 VEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGALMTARPLDRE 455
Query: 461 TAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTI 520
WHNITVLAME +N +Q+ + I++LDVNDN PE YEA VCE+AK GQLIQT+
Sbjct: 456 EFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCENAKAGQLIQTV 515
Query: 521 SVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPIL 580
S VD+D+P+ G FY+ L PEA +NP+F++ D QDNTA + T+ GF +QEQ VF LPIL
Sbjct: 516 SAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDNTARILTRRSGFRQQEQSVFHLPIL 575
Query: 581 VVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVL 640
+ DSG P LSSTGTLTI++C CD G + SC+ A+++ SLS GALIA+L C+ +L+VL
Sbjct: 576 IADSGQPVLSSTGTLTIQVCSCDDDGHVMSCSPEAYMLPVSLSRGALIAILACIFVLLVL 635
Query: 641 VLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGG 700
VLLIL++RRH K D++E++ +N+++Y+DEGGGE+DTEA+D++A+ + +
Sbjct: 636 VLLILSMRRHRKQPYIIDDEENIHENIVRYDDEGGGEEDTEAFDIAAMWNPRE------- 688
Query: 701 DGGGSAGGGAGGGSGGGAGSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADG 760
G A Q LP E SL + P S ++ K+ AD
Sbjct: 689 ------------AQAGAAPKTRQDMLP-EIESLSRYVPQTCAVNSTVHSYVLAKLYEADM 735
Query: 761 DLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGHR 820
DL PP+D+ QTY FEG S A SLSSL S +S SEQ F +L+ WGPRFR LA LY
Sbjct: 736 DLWAPPFDSLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAELYGASE 795
Query: 821 G 821
G
Sbjct: 796 G 796
>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
Length = 799
Score = 804 bits (2076), Expect = 0.0
Identities = 395/812 (48%), Positives = 564/812 (69%), Gaps = 31/812 (3%)
Query: 17 SPALLLLLLLPP----PPTLLGRLWAAGTPSPSAPGARQDGALGAGRVKRGWVWNQFFVV 72
+P ++L + LPP P ++ +G+P + L R KRGWVWNQ FV+
Sbjct: 14 TPLIILWITLPPCIYMAPMNQSQVLMSGSPLELNSLGEEQRILN--RSKRGWVWNQMFVL 71
Query: 73 EEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTF 132
EE++G EP+ VG++H+D D G IKY +SG+GAGTIF I+++TGDIHA++RLDRE+K
Sbjct: 72 EEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAE 131
Query: 133 YTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMA 192
YTL AQA D T++ LEP SEFIIKVQDIND+ P FL+GPY +V E+S GTSV V A
Sbjct: 132 YTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTA 191
Query: 193 SDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAG 252
+DADDP YG+SA+LVYS+L+G+ +F+++P+T +I+TA+P++DRE++E Y VVIQA DM G
Sbjct: 192 TDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGG 251
Query: 253 QLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDM 312
GGLSG+TT+T+ +TDVNDNPP+F Q +Y FS+ E +GTA+GRVKA D D+GEN
Sbjct: 252 HSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQS 311
Query: 313 TYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADL 372
+Y + D G +F++T+D+ Q+ II ++K LDFE++ +T+ +EA N +DPRF+
Sbjct: 312 SYDIID--GDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGR 369
Query: 373 GTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAI 432
G F+D A V++ V D DEPP F P+ LLEV E+A + S++G VTARDPD + P+R++I
Sbjct: 370 GPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSI 429
Query: 433 DRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDV 492
DR +DL++ F+I+AD G I LDRE + WHNIT++A E NH+Q+SR + I++LDV
Sbjct: 430 DRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDV 489
Query: 493 NDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLD 552
NDN PE A+ YEA +CE+ KPGQ+IQT+S +D+D+P+ GH F + L+PE +NP+F++
Sbjct: 490 NDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKK 549
Query: 553 IQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCN 612
+DN+ ++ +H GFNRQ+Q+V+ LPI++ DSG P LSST TLTIR+CGC + G +QSCN
Sbjct: 550 NEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCN 609
Query: 613 TTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYND 672
A+V+ LS GALIA+L C+++L+V+V+L +TLRRH L +DED+R+N+I+Y+D
Sbjct: 610 VEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDD 669
Query: 673 EGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSERHS 732
EGGGE+DTEA+D++ L++ G G P+ + +
Sbjct: 670 EGGGEEDTEAFDIATLQN-----------------------PDGINGFLPRKDIKPDLQF 706
Query: 733 LPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGS 792
+P+ +P P+ +FI+ ++ AD D + PPYD+ Q Y +EG S A SLSSL S +
Sbjct: 707 MPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTT 766
Query: 793 SGSEQDFAYLSSWGPRFRPLAALYAGHRGDDE 824
S S+Q+F YLS WGPRF+ L LY+ D E
Sbjct: 767 SDSDQNFDYLSDWGPRFKRLGELYSVGESDKE 798
>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
Length = 789
Score = 802 bits (2072), Expect = 0.0
Identities = 399/791 (50%), Positives = 544/791 (68%), Gaps = 48/791 (6%)
Query: 43 SPSAPGARQDGALGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTIS 102
S G +D R KRGW+WNQFF++EEYTGT+ YVGK+H+D D+GDG +KY ++
Sbjct: 34 SKKIAGLTKDDGKMLRRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILT 93
Query: 103 GEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDIN 162
G+GAG++F+IDE TGDIHA ++LDRE+K+ Y LRA+A DR T R +EPESEFIIK+ DIN
Sbjct: 94 GDGAGSLFVIDENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDIN 153
Query: 163 DSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPK 222
D+EP+F Y SV E+S GTSV+QV A+DADD YG+SA++VYS+L G+ +F+VDP+
Sbjct: 154 DNEPKFTKDLYTASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQPYFSVDPE 213
Query: 223 TGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMY 282
+G+I+TA+PD+ RE++E+Y+VVIQA DM GQ+GGLSG+TTV I +TDVN+NPPRFPQ Y
Sbjct: 214 SGIIKTALPDMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTY 273
Query: 283 QFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVV 342
QF+ ES P+GT +GR+KA D DVGEN +M Y + + G D+F V TD DTQE II V
Sbjct: 274 QFNSPESVPLGTHLGRIKANDPDVGENAEMEYSIAE--GDGADMFDVITDKDTQEGIITV 331
Query: 343 QKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLE 402
++ LDFE+Q ++T+ ++A N DPRF LG F+D A+V+++V D+DEPP F S L+E
Sbjct: 332 KQNLDFENQMLYTLRVDASNTHPDPRFLHLGPFKDTAVVKISVEDIDEPPVFTKVSYLIE 391
Query: 403 VQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETA 462
V ED + GS++G VTA DPDA N ++Y++DR +D+D+IF I ++ G+I T K LDRE++
Sbjct: 392 VDEDVKEGSIIGQVTAYDPDARNNLIKYSVDRHTDMDRIFGIHSENGSIFTLKALDRESS 451
Query: 463 GWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISV 522
WHNITV A E +N Q S + IRILD+ND+ PE A YE VCE+AKPGQLIQT+SV
Sbjct: 452 PWHNITVTATEINNPKQSSHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQTVSV 511
Query: 523 VDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVV 582
+D+D+P GH+F+F VPE NP+F+++D +DNTA + T+ G++R + + LPIL+
Sbjct: 512 MDKDDPPRGHKFFFEPVPEFTLNPNFTIVDNKDNTAGIMTRKDGYSRNKMSTYLLPILIF 571
Query: 583 DSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVL 642
D+ P SSTGTLTIR+C CD+ G +QSC A +++A LS GAL+A+L+CVLIL++LV+
Sbjct: 572 DNDYPIQSSTGTLTIRVCACDNQGNMQSCTAEALILSAGLSTGALVAILLCVLILLILVV 631
Query: 643 LILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDG 702
L L+R K +D+RDN++ YNDEGGGE+DT+A+D+ LR+
Sbjct: 632 LFAALKRQRKKEPLIISKDDVRDNIVTYNDEGGGEEDTQAFDIGTLRN------------ 679
Query: 703 GGSAGGGAGGGSGGGAGSPPQAHLPSERHSLPQGPPSPEPDFSVFR-----------DFI 751
P+A S+ + PE F + R DFI
Sbjct: 680 -------------------PEAREDSKL----RRDVMPETIFQIRRTVPLWENIDVQDFI 716
Query: 752 SRKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRP 811
R++ D D S PPYD+ TYA+EG DS A SLSSL S ++ QD+ YLS WGPRF+
Sbjct: 717 HRRLKENDADPSAPPYDSLATYAYEGNDSIADSLSSLESLTADCNQDYDYLSDWGPRFKK 776
Query: 812 LAALYAGHRGD 822
LA +Y G D
Sbjct: 777 LADMYGGDDSD 787
>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
Length = 788
Score = 801 bits (2070), Expect = 0.0
Identities = 395/776 (50%), Positives = 550/776 (70%), Gaps = 30/776 (3%)
Query: 50 RQDGALGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTI 109
R DG + R KRGW+WNQFF++EEYTG++ YVGK+HSD D+GDG++KY +SG+GAGT+
Sbjct: 43 RSDGKI-LHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTL 101
Query: 110 FLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFL 169
F+IDE TGDIHA R+DRE+K FYTLRAQA +R T R +EPESEF+IK+ DIND+EP F
Sbjct: 102 FIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFP 161
Query: 170 HGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTA 229
Y SV E+S GTSV+QV A+DADDP+YG+SAR++YS+L G+ +F+V+P+TG+IRTA
Sbjct: 162 EEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGIIRTA 221
Query: 230 VPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQES 289
+P+++RE++E+Y+VVIQA DM GQ+GGLSG+TTV I +TDVNDNPPRFPQ + ES
Sbjct: 222 LPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLES 281
Query: 290 APIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFE 349
+P+GTA+G VKA D+D G+N ++ Y + D G D+F + T+ DTQE II V+K LD+E
Sbjct: 282 SPVGTAIGSVKATDADTGKNAEVEYRIID--GDGTDMFDIVTEKDTQEGIITVKKPLDYE 339
Query: 350 SQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQV 409
S+ ++T+ +EA N VDPRF LG F+D IV++++ DVDEPP F S L EV ED +V
Sbjct: 340 SRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEV 399
Query: 410 GSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITV 469
G+++G V ARDPD+ + P+R+++DR +DLD+IF+I + G++ T K LDRE + WHN+TV
Sbjct: 400 GTIIGTVMARDPDSISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTV 459
Query: 470 LAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQ 529
+A E +N + +R ++ +RILDVNDN P+ A Y+ VCE+A+PGQLIQTIS VD+D+P
Sbjct: 460 IAAEINNPKETTRVAVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPL 519
Query: 530 GGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTL 589
GG +F+F L A NP+F++ D +DNTA + T+ GFNR E + LP+++ D+ P
Sbjct: 520 GGQKFFFSL---AAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQ 576
Query: 590 SSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRR 649
SSTGTLTIR+C CDS G +QSC+ A ++ A LS GALIA+L+C++IL+V+V+L L+R
Sbjct: 577 SSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTGALIAILLCIIILLVIVVLFAALKR 636
Query: 650 HHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGG 709
K ED+RDN++ YNDEGGGE+DT+A+D+ LR+ E K
Sbjct: 637 QRKKEPLILSKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIEEKK----------- 685
Query: 710 AGGGSGGGAGSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDA 769
+ + E +P+ P+ PD + RDFI+ ++ D D + PPYD+
Sbjct: 686 ------------LRRDIIPETLFIPRRTPT-APDNTDVRDFINERLKEHDLDPTAPPYDS 732
Query: 770 FQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGHRGDDEA 825
TYA+EG DS A SLSSL SG++ +Q++ YL WGPRF LA +Y G D ++
Sbjct: 733 LATYAYEGNDSIAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYGGGESDKDS 788
>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 798 bits (2061), Expect = 0.0
Identities = 405/758 (53%), Positives = 544/758 (71%), Gaps = 26/758 (3%)
Query: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGD 118
R KRGWVWNQFFV+EE+ G +P YVGK+HS+SD+GDG++KY ++GEGAGTIF+ID+ TGD
Sbjct: 50 RPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGTIFIIDDTTGD 109
Query: 119 IHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVA 178
IH+ + LDREQKT Y L AQA DR TN+ LEPESEFIIKVQDIND+ P+F GPYI +V
Sbjct: 110 IHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVP 169
Query: 179 ELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQ 238
E+S GTSV+QV A+DADDPTYG+SAR+VYS+L G+ +F+VDPKTGVIRTA+ ++DRE++
Sbjct: 170 EMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDREAR 229
Query: 239 ERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGR 298
E Y VVIQA DMAGQ+GGLSGSTTV I +TDVNDNPPRFPQK YQ + ESA +G+AVG+
Sbjct: 230 EHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQVGSAVGK 289
Query: 299 VKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVIL 358
+KA D+D G N DMTY + + G +F ++TD +T+E I+ ++K L++E + +T+ +
Sbjct: 290 IKANDADTGSNADMTYSIINGDGMG--IFSISTDKETREGILSLKKPLNYEKKKSYTLNI 347
Query: 359 EALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTA 418
E N +D RF+ LG F+D ++++ V DVDEPP F PS L+EV E+A++G++VG V A
Sbjct: 348 EGANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLA 407
Query: 419 RDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHA 478
+DPD+ N VRY I+ + D+ F+IDA+TG I T K LDRE W+NITV A E DN
Sbjct: 408 QDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPD 467
Query: 479 QLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRL 538
LS ++ IR+LDVNDNPPELA Y+ VCE++KPGQ+I TIS D+D+ G RF F L
Sbjct: 468 LLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFL 527
Query: 539 VPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIR 598
P NP+F+L D +DNTA++ T+ F+R QDV++LPI++ D G P+LSS+ TLTIR
Sbjct: 528 DERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIR 587
Query: 599 ICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSD 658
+C C+ G +++C+ AF+ +A LS GALIA+L+CVLIL+ +V+L +TLRR K L
Sbjct: 588 VCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSKKEPLIIS 647
Query: 659 EDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGA 718
E ED+R+NV+ Y+DEGGGE+DTEA+D++ALR+ ELK
Sbjct: 648 E-EDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELK-------------------- 686
Query: 719 GSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGA 778
+ + E P+ S + ++FI +++A AD D SVPPYD+ QTYA+EG
Sbjct: 687 ---YRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQ 743
Query: 779 DSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALY 816
S A S+SSL S ++ S+QD+ YL WGP F+ LA LY
Sbjct: 744 RSEAGSISSLDSATTQSDQDYHYLGDWGPEFKKLAELY 781
>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 788 bits (2034), Expect = 0.0
Identities = 401/809 (49%), Positives = 549/809 (67%), Gaps = 29/809 (3%)
Query: 20 LLLLLLLPPPPTLLGRLWAAGTPSPSAPGARQ---DGALGAGRVKRGWVWNQFFVVEEYT 76
LLL + P PTL L + P+ A + + R KR W+WNQFF++EEYT
Sbjct: 8 LLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYT 67
Query: 77 GTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLR 136
G++ YVGK+HSD D GDG++KY +SG+GAG +F+I+E TGDI A +RLDRE+K Y LR
Sbjct: 68 GSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILR 127
Query: 137 AQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDAD 196
AQA +R T R +EPESEFIIK+ DIND+EP F Y +V E+S GT V+QV A+DAD
Sbjct: 128 AQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDAD 187
Query: 197 DPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGG 256
DPTYG+SA++VYS+L G+ +F+V+ +TG+I+TA+ ++DRE++E+Y+VVIQA DM GQ+GG
Sbjct: 188 DPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGG 247
Query: 257 LSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHL 316
LSG+TTV I +TDVNDNPPRFPQ YQF ES+P GT +GR+KA D+DVGEN ++ Y +
Sbjct: 248 LSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSI 307
Query: 317 KDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFR 376
D G D+F V TD +TQE II V+K LDFE + V+T+ +EA N +V+PRF LG F+
Sbjct: 308 TD--GEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFK 365
Query: 377 DQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRES 436
D A VR+ V DVDEPP F + +L+++EDAQ+ + +G VTA+DPDAA PV+Y++DR +
Sbjct: 366 DSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHT 425
Query: 437 DLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNP 496
D+D+IF+ID+ G+I T K LDRET WHNITV+A E +N Q SR L I++LDVNDN
Sbjct: 426 DMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNA 485
Query: 497 PELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDN 556
PE A YE VCE AK QLIQT+ VD+D+P GH+F F L PEA S +F++ D +DN
Sbjct: 486 PEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDN 545
Query: 557 TAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAF 616
TA + T+ G+NR E + LP+++ D+ P SSTGT+T+R+C CD G +QSC+ A
Sbjct: 546 TAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEAL 605
Query: 617 VMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGG 676
+ LS GAL+A+L+C++IL+V V+L LRR K ED+RDN++ YNDEGGG
Sbjct: 606 IHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGG 665
Query: 677 EQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSERHSLPQG 736
E+DT+A+D+ LR+ + K + + E LP+
Sbjct: 666 EEDTQAFDIGTLRNPEAIEDNK-----------------------LRRDIVPEALFLPRR 702
Query: 737 PPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSE 796
P+ + V RDFI++++ D D + PPYD+ TYA+EG S A SLSSL S ++ ++
Sbjct: 703 TPTARDNTDV-RDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDAD 761
Query: 797 QDFAYLSSWGPRFRPLAALYAGHRGDDEA 825
QD+ YLS WGPRF+ LA +Y G D ++
Sbjct: 762 QDYDYLSDWGPRFKKLADMYGGVDSDKDS 790
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 785 bits (2027), Expect = 0.0
Identities = 387/767 (50%), Positives = 538/767 (70%), Gaps = 30/767 (3%)
Query: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGD 118
RVKRGWVWNQFFV+EEY G+EP YVGK+HSD D+G+G +KYT+SG+GAGT+F IDE TGD
Sbjct: 51 RVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGD 110
Query: 119 IHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVA 178
IHA+ LDRE+K FYTLRAQA D T + LEPESEFIIKVQDIND+EP+FL GPY+ +V
Sbjct: 111 IHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVP 170
Query: 179 ELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQ 238
E+SP G V+QV A+DADDPTYG+SAR+VYS+L G+ +F++DPKTGVIRTA+P++DRE +
Sbjct: 171 EMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVK 230
Query: 239 ERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGR 298
E+Y+V+IQA DM GQLGGL+G+T V I +TDVNDNPPRFP+ ++ + ES+PIG+A+GR
Sbjct: 231 EQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGR 290
Query: 299 VKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVIL 358
++A D D G+N ++ Y++ GG++F + TD DTQE +I ++K LDFE++ +T +
Sbjct: 291 IRAVDPDFGQNAEIEYNI--VPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKV 348
Query: 359 EALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTA 418
EA N +D RF G F+D A V+++V DVDEPP F P +EV ED VG+++G VTA
Sbjct: 349 EASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTA 408
Query: 419 RDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHA 478
+D D + VRY ID +SD D F ID + G I T + LDRE+ +N +++A + N
Sbjct: 409 QDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPL 468
Query: 479 QLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRL 538
S+ ++ I +LDVN+ PPE++ PYE AVCE+AKPGQ+IQ +S DRD G +F FRL
Sbjct: 469 LTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRL 528
Query: 539 VPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIR 598
PEA P+F++ D ++NTA + T+ G++R++Q+++FLP+++ DS P SST T+TIR
Sbjct: 529 SPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIR 588
Query: 599 ICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSD 658
+C CDS GTI SCN A + LS GALIA+L+C++IL+ +V+L + LRR K
Sbjct: 589 VCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMT 648
Query: 659 EDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGA 718
ED+RDNVI Y+DEGGGE+DT+A+D+ ALR+ E K
Sbjct: 649 SKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENK-------------------- 688
Query: 719 GSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGA 778
+ + + LP+ P P D + RDFI +++ D D + PPYD+ TYA+EG+
Sbjct: 689 ---IRRDIKPDSLCLPRQRP-PMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGS 744
Query: 779 DSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGHRGDDEA 825
S A SLSS+ S ++ ++QD+ YL+ WGPRF+ LA ++ G++E+
Sbjct: 745 GSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMF----GEEES 787
>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
Length = 796
Score = 782 bits (2020), Expect = 0.0
Identities = 399/779 (51%), Positives = 538/779 (69%), Gaps = 31/779 (3%)
Query: 44 PSAPGARQDGALGA--GRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTI 101
PS G + G G R KRGWVWNQFFV+EEYTG +P+ VG++HSD D GDG IKY +
Sbjct: 33 PSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYIL 92
Query: 102 SGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDI 161
SGEGAGTIF+ID+ +G+IHA + LDRE++ YTL AQA DR TNR LEP SEFI+KVQDI
Sbjct: 93 SGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDI 152
Query: 162 NDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDP 221
ND+ P FLH Y +V E S GTSV+QV ASDADDPTYG+SA+LVYS+L+G+ +F+V+
Sbjct: 153 NDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEA 212
Query: 222 KTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKM 281
+TG+IRTA+P++DRE++E Y VVIQA DM G +GGLSG+T VTI +TDVNDNPP+FPQ +
Sbjct: 213 QTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSV 272
Query: 282 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIV 341
YQ S+ E+A G VGRVKA+D D+GEN +TY++ D G + F++TTD +TQE +I
Sbjct: 273 YQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVD--GDGMESFEITTDYETQEGVIK 330
Query: 342 VQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLL 401
++K +DFE++ +++ +EA N +DP+F G F+D V+++V D DEPP F PS +
Sbjct: 331 LKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIH 390
Query: 402 EVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRET 461
EVQE+A G++VG V A+DPDAAN P+RY+IDR +DLD+ F I+ + G I T K LDRE
Sbjct: 391 EVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE 450
Query: 462 AGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCE--DAKP--GQLI 517
W NITV A E N Q ++ + IR+LDVNDN P+ A PYE +CE KP Q I
Sbjct: 451 TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPI 510
Query: 518 QTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFL 577
TIS D+D+ G RF F L PE NP+F++ D +DNTA V+ + GF+RQ+QD++ L
Sbjct: 511 VTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLL 570
Query: 578 PILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLIL 637
PI++ D G P +SST TLTI++CGCD +G + SCN A+++ A LS GALIA+L C++IL
Sbjct: 571 PIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVIL 630
Query: 638 VVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGEL 697
+V+V+L +TLRR K L E+ED+R+N+I Y+DEGGGE+DTEA+D++ L++
Sbjct: 631 LVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQN------- 683
Query: 698 KGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVAL 757
G G P+ + E +P+ P P+ DFI+ ++
Sbjct: 684 ----------------PDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQE 727
Query: 758 ADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALY 816
AD D + PPYD+ Q Y +EG S A SLSSL S ++ S+ D+ YL +WGPRF+ LA LY
Sbjct: 728 ADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLY 786
>gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]
Length = 781
Score = 674 bits (1740), Expect = 0.0
Identities = 371/790 (46%), Positives = 499/790 (63%), Gaps = 40/790 (5%)
Query: 33 LGRLWAAGTPSPSAPGARQDGALGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDE 92
+GRL A P+ + G+R+ R +R WVWNQFFV+EEY G EP+ +GK+HSD D
Sbjct: 18 MGRLAA---PARAWAGSREHPGPALLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDR 74
Query: 93 GDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPES 152
G+G KY ++GEGAGT+F+IDE TG+IH + LDRE+K Y L AQA DRA+NR LEP S
Sbjct: 75 GEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPS 134
Query: 153 EFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLD 212
EFIIKVQDIND+ P F GPY +V E+S GTSV+QV A DADDP+YG+SA+LVY+VLD
Sbjct: 135 EFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLD 194
Query: 213 GEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVND 272
G F+VDP+TGV+RTA+P++DRE+QE + VVIQA DM G +GGLSGSTTVT+ ++DVND
Sbjct: 195 GLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVND 254
Query: 273 NPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTD 332
NPP+FPQ +YQFS+ E+A GT VGR++A+D D+G+N M Y + D G + F ++TD
Sbjct: 255 NPPKFPQSLYQFSVVETAGPGTLVGRLRAQDPDLGDNALMAYSILD--GEGSEAFSISTD 312
Query: 333 SDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPP 392
++ ++ V+K LDFESQ ++ +EA N +DP + G F+D A VRVAV D EPP
Sbjct: 313 LQGRDGLLTVRKPLDFESQRSYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPP 372
Query: 393 EFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIV 452
F + L V E+ G+LVG ++A D D+ P+RY+I SD ++ F I + G I
Sbjct: 373 AFTQAAYHLTVPENKAPGTLVGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGTIH 432
Query: 453 TGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAK 512
T LDRE WHN+TVLA E D+ AQ SR + I+ LD NDN P+LA PY+ VC+ A
Sbjct: 433 TAAPLDREARAWHNLTVLATELDSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAA 492
Query: 513 PGQLIQTISVVDRDEPQGGHRFYFR--LVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQ 570
PGQLIQ I +DRDE F+ L P+A +F++ D +D +A++ +
Sbjct: 493 PGQLIQVIRALDRDEVGNSSHVSFQGPLGPDA----NFTVQDNRDGSASLLLPSRPAPPR 548
Query: 571 EQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIAL 630
+ +PI + D G P LSST T+T+ +C C G++ SC A + AA LS GAL+A+
Sbjct: 549 HAP-YLVPIELWDWGQPALSSTATVTVSVCRCQPDGSVASCWPEAHLSAAGLSTGALLAI 607
Query: 631 LVCVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRS 690
+ CV L+ LV+L + LRR + L E+ED+R+N+I Y+DEGGGE+DTEA+D++AL++
Sbjct: 608 ITCVGALLALVVLFVALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDITALQN 667
Query: 691 LYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAH--LPSERHSLPQGPPSPEPDFSVFR 748
G+ A PP LP R S PP P +
Sbjct: 668 --------------------PDGAAPPAPGPPARRDVLPRARVSRQPRPPGP----ADVA 703
Query: 749 DFISRKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGS--SGSEQDFAYLSSWG 806
++ ++ AD D VPPYD+ Q Y +EG S SLSSL SGS G+ L WG
Sbjct: 704 QLLALRLREADEDPGVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGAPGPAEPLDDWG 763
Query: 807 PRFRPLAALY 816
P FR LA LY
Sbjct: 764 PLFRTLAELY 773
>gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens]
Length = 819
Score = 655 bits (1691), Expect = 0.0
Identities = 371/828 (44%), Positives = 499/828 (60%), Gaps = 78/828 (9%)
Query: 33 LGRLWAAGTPSPSAPGARQDGALGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDE 92
+GRL A P+ + G+R+ R +R WVWNQFFV+EEY G EP+ +GK+HSD D
Sbjct: 18 MGRLAA---PARAWAGSREHPGPALLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDR 74
Query: 93 GDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPES 152
G+G KY ++GEGAGT+F+IDE TG+IH + LDRE+K Y L AQA DRA+NR LEP S
Sbjct: 75 GEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPS 134
Query: 153 EFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLD 212
EFIIKVQDIND+ P F GPY +V E+S GTSV+QV A DADDP+YG+SA+LVY+VLD
Sbjct: 135 EFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLD 194
Query: 213 GEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVND 272
G F+VDP+TGV+RTA+P++DRE+QE + VVIQA DM G +GGLSGSTTVT+ ++DVND
Sbjct: 195 GLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVND 254
Query: 273 NPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTD 332
NPP+FPQ +YQFS+ E+A GT VGR++A+D D+G+N M Y + D G + F ++TD
Sbjct: 255 NPPKFPQSLYQFSVVETAGPGTLVGRLRAQDPDLGDNALMAYSILD--GEGSEAFSISTD 312
Query: 333 SDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPP 392
++ ++ V+K LDFESQ ++ +EA N +DP + G F+D A VRVAV D EPP
Sbjct: 313 LQGRDGLLTVRKPLDFESQRSYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPP 372
Query: 393 EFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIV 452
F + L V E+ G+LVG ++A D D+ P+RY+I SD ++ F I + G I
Sbjct: 373 AFTQAAYHLTVPENKAPGTLVGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGTIH 432
Query: 453 TGKGLDRETAGWHNITVLAME--------------------------------------A 474
T LDRE WHN+TVLA E
Sbjct: 433 TAAPLDREARAWHNLTVLATELGWSWGPERGWVPLLVAEWSAPAAPPQRSPVGSAVGIPQ 492
Query: 475 DNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRF 534
D+ AQ SR + I+ LD NDN P+LA PY+ VC+ A PGQLIQ I +DRDE
Sbjct: 493 DSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSHV 552
Query: 535 YFR--LVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSST 592
F+ L P+A +F++ D +D +A++ + + +PI + D G P LSST
Sbjct: 553 SFQGPLGPDA----NFTVQDNRDGSASLLLPSRPAPPRHAP-YLVPIELWDWGQPALSST 607
Query: 593 GTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHK 652
T+T+ +C C G++ SC A + AA LS GAL+A++ CV L+ LV+L + LRR +
Sbjct: 608 ATVTVSVCRCQPDGSVASCWPEAHLSAAGLSTGALLAIITCVGALLALVVLFVALRRQKQ 667
Query: 653 SHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGG 712
L E+ED+R+N+I Y+DEGGGE+DTEA+D++AL++
Sbjct: 668 EALMVLEEEDVRENIITYDDEGGGEEDTEAFDITALQN--------------------PD 707
Query: 713 GSGGGAGSPPQAH--LPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAF 770
G+ A PP LP R S PP P + ++ ++ AD D VPPYD+
Sbjct: 708 GAAPPAPGPPARRDVLPRARVSRQPRPPGP----ADVAQLLALRLREADEDPGVPPYDSV 763
Query: 771 QTYAFEGADSPAASLSSLHSGS--SGSEQDFAYLSSWGPRFRPLAALY 816
Q Y +EG S SLSSL SGS G+ L WGP FR LA LY
Sbjct: 764 QVYGYEGRGSSCGSLSSLGSGSEAGGAPGPAEPLDDWGPLFRTLAELY 811
>gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens]
Length = 772
Score = 646 bits (1667), Expect = 0.0
Identities = 336/758 (44%), Positives = 483/758 (63%), Gaps = 33/758 (4%)
Query: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGD 118
RVKRGWVWNQFFV EE T ++G++ SD D G+ + +Y + G GAG+ F+IDE TGD
Sbjct: 40 RVKRGWVWNQFFVPEEMNTTSH-HIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGD 98
Query: 119 IHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVA 178
I+A+++LDRE+++ Y LRAQ D AT R +EPESEF+IKV DIND+EP+FL PY V
Sbjct: 99 IYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVP 158
Query: 179 ELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQ 238
E+SP GT V+QV ASDADDP+ G++ARL+YS+L G+ +F+V+P TGVIR + +DRE Q
Sbjct: 159 EMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRIS-SKMDRELQ 217
Query: 239 ERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGR 298
+ Y V+IQA DM GQ G LSG+T+V I ++DVNDN P F + +Y+ ++ ESAP GT++G
Sbjct: 218 DEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGT 277
Query: 299 VKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVIL 358
+ A D+D+GEN +M Y ++++ S F + T+ +TQE I++++K++DFE Q + +
Sbjct: 278 IMAYDNDIGENAEMDYSIEEDDSQ---TFDIITNHETQEGIVILKKKVDFEHQNHYGIRA 334
Query: 359 EALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTA 418
+ N V + T +++ V DVDEPP F P + EV E+ GS VGVV+A
Sbjct: 335 KVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSA 394
Query: 419 RDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHA 478
DPD P+RY+I R ++F+I+ D G I T LDRE + W+N+++ A E N
Sbjct: 395 TDPDNRKSPIRYSITRS----KVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIE 449
Query: 479 QLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRL 538
Q+S L +++L++ND+ PE + YE VCE+A GQ+IQTIS VDRDE H FYF L
Sbjct: 450 QISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNL 509
Query: 539 VPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIR 598
E +N F+++D QDNTA + T GFN QE+ VF++ IL+ D+G P+L+ST TLTI
Sbjct: 510 SVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIH 569
Query: 599 ICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSD 658
+C C SG+ Q+C V++ +IA+L+C++I+ + L L L++ K L +
Sbjct: 570 VCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPE 629
Query: 659 EDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGA 718
+ ED R+N+ +Y+DEGGGE+DTEA+D++ LRS E K
Sbjct: 630 KSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERK-------------------- 669
Query: 719 GSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGA 778
+ +E SL + PD ++FR FI K+ A+ D PP+D+ QTYAFEG
Sbjct: 670 ---TRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGT 726
Query: 779 DSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALY 816
S A SLSSL S S ++ + YL+ GPRF+ LA ++
Sbjct: 727 GSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMF 764
>gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens]
Length = 784
Score = 464 bits (1194), Expect = e-130
Identities = 297/803 (36%), Positives = 422/803 (52%), Gaps = 40/803 (4%)
Query: 22 LLLLLPPPPTLLGRLWAAGTPSPSAPGARQDGAL---GAGRVKRGWVWNQFFVVEEYTGT 78
L++LL LG L A + A A++D R KR W+WNQ + EE +
Sbjct: 4 LMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTS 63
Query: 79 EPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQ 138
P +VGKI S + KY + GE G +F +D TGD+ A+ERLDRE + Y L A
Sbjct: 64 LPHHVGKIKSSVSRKNA--KYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAV 121
Query: 139 ARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDP 198
D+ T LE S F IKV D+ND+ P F H + SV E S GTSV+ V A DADDP
Sbjct: 122 IVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDP 181
Query: 199 TYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLS 258
T G A ++Y +L G+ +F +D +G I T LDRE Q RYE+V++A D G L G S
Sbjct: 182 TVGDHASVMYQILKGKEYFAID-NSGRIITITKSLDREKQARYEIVVEARDAQG-LRGDS 239
Query: 259 GSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKD 318
G+ TV + + D+NDN P F Q Y F + E +GT+VG + ED D +N Y +
Sbjct: 240 GTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSIL- 298
Query: 319 ESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQ 378
D F + T+ E II K LD+E ++ I+EA + +D R+ ++
Sbjct: 299 -RGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMS-PPAGNR 356
Query: 379 AIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDL 438
A V + +TDVDEPP F+ P +++E+ Q L+G V A DPDAA + Y+I R SD
Sbjct: 357 AQVIINITDVDEPPIFQQPFYHFQLKEN-QKKPLIGTVLAMDPDAARHSIGYSIRRTSDK 415
Query: 439 DQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADN----HAQLSRASLRIRILDVND 494
Q F + G I K LDRE W+N+TV A E D+ + S + I +LD ND
Sbjct: 416 GQFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDEND 474
Query: 495 NPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQ 554
N PE A PY+ VCE+A GQL+ IS +D+D +F F L E +F+L D
Sbjct: 475 NAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTE----NNFTLTDNH 530
Query: 555 DNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTT 614
DNTA + ++ F+R+ V FLP+++ D+G P+ + T TLT+ +C C+ G C
Sbjct: 531 DNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDM 590
Query: 615 AFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDED-EDMRDNVIKYNDE 673
A + S+ A++A+L+C+L + V+ LLI RR K + + ++ + ++ Y++E
Sbjct: 591 AAQVGVSIQ--AVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEE 648
Query: 674 GGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSERHSL 733
GGGE DT +YD+S L S+ GG + L ++
Sbjct: 649 GGGEMDTTSYDVSVLNSV-----------------RRGGAKPPRPALDARPSLYAQVQKP 691
Query: 734 PQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSS 793
P+ P I K AD D PPYD Y +EG++S A SLSSL + SS
Sbjct: 692 PRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSS 751
Query: 794 GSEQDFAYLSSWGPRFRPLAALY 816
S+ D+ +L+ WGPRF+ LA LY
Sbjct: 752 DSDVDYDFLNDWGPRFKMLAELY 774
>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
Length = 916
Score = 372 bits (955), Expect = e-103
Identities = 276/816 (33%), Positives = 411/816 (50%), Gaps = 62/816 (7%)
Query: 34 GRLWAAGTPSPSA-----PGARQDGALGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHS 88
G+ A PSP P + A G R KR WV V E G P + +I S
Sbjct: 136 GKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRS 195
Query: 89 DSDEGDGAIKYTISGEGAGT----IFLIDELTGDIHAMERLDREQKTFYTLRAQARDRAT 144
D D D I+Y+I+G GA +F ID ++G ++ +DRE+ Y LRA A D
Sbjct: 196 DKDN-DIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNG 254
Query: 145 NRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSA 204
N++ P + I V D+ND+ P F++ Y GSV E S GT VM V A+DADD T +
Sbjct: 255 NKVENP-IDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGM 313
Query: 205 ---RLVYSVLDG--EHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLG-GLS 258
R+V ++ FT++ +TG I T LDRE ++Y V++QATDM G L GLS
Sbjct: 314 VRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLS 373
Query: 259 GSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDV--GENTDMTYHL 316
+ T I VTDVNDNPP F + + E+ + T V + D D N + Y +
Sbjct: 374 NTATAIITVTDVNDNPPEFTASTFAGEVPENR-VETVVANLTVMDRDQPHSPNWNAVYRI 432
Query: 317 KDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFR 376
SG F V TD T E ++ V K +D+E + + N+ + +F+
Sbjct: 433 ISGDPSGH--FSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQM-SFQ 489
Query: 377 DQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRE 435
A V +++ D++E P F L+ ++E G+++ +A DPD + VRY+ +
Sbjct: 490 STAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYS--KL 547
Query: 436 SDLDQIFDIDADTGAIVTGKGLDRETAGWHN----ITVLAMEADNHAQLSRASLRIRILD 491
SD I+A G I T LDRE+ N T LA + +L+I ++D
Sbjct: 548 SDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLID 607
Query: 492 VNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLL 551
+NDN PEL P EA +CE + T + D D G + F VP A ++++
Sbjct: 608 INDNAPELL-PKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRK-NWTIT 665
Query: 552 DIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSC 611
+ + A + + + E ++ +PI+V DSG P LS+T + +++C CD +G C
Sbjct: 666 RLNGDYAQLSLRILYL---EAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNG---DC 719
Query: 612 NTTAFVMAASLSPGALIALLVCVLILVVLVLL-ILTLRRH----HKSHLSSDEDEDMRDN 666
T V AA L GA++A+L+C+LIL+ +VLL ++ ++R H L D ++D+RDN
Sbjct: 720 TTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDN 779
Query: 667 VIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHL 726
++KY++EGGGE+D + YD+S L+ G + S G G+ PQ
Sbjct: 780 ILKYDEEGGGEEDQD-YDLSQLQQPEAMGHVP------SKAPGVRRVDERPVGAEPQ--- 829
Query: 727 PSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADSPAASLS 786
P P P P DFI+ + AD D + PPYD+ + +EG+ S A S+S
Sbjct: 830 ------YPIRPMVPHP--GDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVS 881
Query: 787 SLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGHRGD 822
SL+S SSG +QD+ YL+ WGPRF+ LA +Y G D
Sbjct: 882 SLNSSSSG-DQDYDYLNDWGPRFKKLADMYGGGEED 916
>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
Length = 906
Score = 357 bits (915), Expect = 3e-98
Identities = 264/794 (33%), Positives = 401/794 (50%), Gaps = 72/794 (9%)
Query: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGT----IFLIDE 114
R KR WV + E G P + +I SD D+ + +++Y+++G GA IF+I+
Sbjct: 156 RQKRDWVIPPINLPENSRGPFPQELVRIRSDRDK-NLSLRYSVTGPGADQPPTGIFIINP 214
Query: 115 LTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYI 174
++G + + LDREQ + LRA A D N++ P + +I V D+ND+ P FLH +
Sbjct: 215 ISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENP-IDIVINVIDMNDNRPEFLHQVWN 273
Query: 175 GSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLD------GEHHFTVDPKTGVIRT 228
G+V E S GT VM V A DADDP + L Y ++ + FT++ +TG I T
Sbjct: 274 GTVPEGSKPGTYVMTVTAIDADDPN-ALNGMLRYRIVSQAPSTPSPNMFTINNETGDIIT 332
Query: 229 AVPDLDRESQERYEVVIQATDMAGQ-LGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQ 287
LDRE ++Y ++IQATDM G GLS + T I VTDVNDNPP F + +
Sbjct: 333 VAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVP 392
Query: 288 ESAPIGTAVGRVKAEDSDVGENT--DMTYHLKDESSSGGDV---FKVTTDSDTQEAIIVV 342
E+ + V + D D + Y + SGGD F + TD ++ + ++ V
Sbjct: 393 ENR-VDIIVANLTVTDKDQPHTPAWNAVYRI-----SGGDPTGRFAIQTDPNSNDGLVTV 446
Query: 343 QKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLE 402
K +DFE+ + + + A N+ + + A V V V DV+E P F P ++
Sbjct: 447 VKPIDFETNRMFVLTVAAENQVPLAKGIQHPP-QSTATVSVTVIDVNENPYFAPNPKIIR 505
Query: 403 VQEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRET 461
+E G+++ TA+DPD + +RY + SD ID G I T LDRE+
Sbjct: 506 QEEGLHAGTMLTTFTAQDPDRYMQQNIRYT--KLSDPANWLKIDPVNGQITTIAVLDRES 563
Query: 462 AGW----HNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLI 517
+N T LA + +L+I +LD+NDN P++ P EA CE P +
Sbjct: 564 PNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVL-PQEAETCETPDPNSIN 622
Query: 518 QTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFL 577
T D D G F L P ++++ + + A ++ + E ++ +
Sbjct: 623 ITALDYDIDPNAGPFAFDLPLSPVTIKR-NWTITRLNGDFAQLNLK---IKFLEAGIYEV 678
Query: 578 PILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLIL 637
PI++ DSG P S+ L +++C CDS+G C ++ A L GA+IA+L+C++IL
Sbjct: 679 PIIITDSGNPPKSNISILRVKVCQCDSNG---DCTDVDRIVGAGLGTGAIIAILLCIIIL 735
Query: 638 VVLVLL-ILTLRRHHKSH----LSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLY 692
++LVL+ ++ ++R K L D ++D+RDN++KY++EGGGE+D + Y
Sbjct: 736 LILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQD----------Y 785
Query: 693 DFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSER--HSLPQGPP-SPEPDFSVFRD 749
D +L+ D A P ER H+ PQ P S P D
Sbjct: 786 DLSQLQQPDTVEP-----------DAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGD 834
Query: 750 FISRKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRF 809
FI+ + AD D + PPYD+ + +EG+ S A SLSSL+S SSG EQD+ YL+ WGPRF
Sbjct: 835 FINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRF 894
Query: 810 RPLAALYAGHRGDD 823
+ LA +Y G GDD
Sbjct: 895 KKLADMYGG--GDD 906
>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
Length = 814
Score = 328 bits (842), Expect = 1e-89
Identities = 259/816 (31%), Positives = 379/816 (46%), Gaps = 69/816 (8%)
Query: 32 LLGRLWAAGTPSPSAPGARQDGAL-------GAGRVKRGWVWNQFFVVEEYTGTEPLYVG 84
+LG L + S PG R+ L RV+R WV V E + P +
Sbjct: 8 VLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKRL-PYPLV 66
Query: 85 KIHSDSDEGDGAIKYTISGEGAGT----IFLIDELTGDIHAMERLDREQKTFYTLRAQAR 140
+I SD + G++ Y+I G G +F ID+ TG + LDRE+ + LRA A
Sbjct: 67 QIKSDKQQL-GSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFAL 125
Query: 141 DRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTY 200
D + L +P ++ I V D ND+ P FL + G V E + GT V + A+DADDP
Sbjct: 126 DLGGSTLEDP-TDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPET 184
Query: 201 GSSARLVYSVLD--GEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLS 258
++A L +S+L F++D TG IRT LDRE Y + +Q DM+G GL+
Sbjct: 185 DNAA-LRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGD--GLT 241
Query: 259 GSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKD 318
+ + I + D+NDN P F + + E+ G VGR++ ED D+ + +
Sbjct: 242 ATASAIITLDDINDNAPEFTRDEFFMEAIEAVS-GVDVGRLEVEDRDLPGSPNWVARFTI 300
Query: 319 ESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQ 378
F + TD T E ++ + K LD+ES + + + N+ + A L R Q
Sbjct: 301 LEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNE-APLQAAALRAERGQ 359
Query: 379 AIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDL 438
A VRV V D +EPP F+ + E A G+LV +ARDPD R + ++ D
Sbjct: 360 AKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQ-RLSYSKDYDP 418
Query: 439 DQIFDIDADTGAIVTGKGLDRET----AGWHNITVLAMEADNHAQLSRASLRIRILDVND 494
+ +DA TG I T L + GW+ VLA + + + + +L I IL+VND
Sbjct: 419 EDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVND 478
Query: 495 NPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPS-NPHFSLLDI 553
+ P LA P ++C + G + + D D P G F+F+L P P ++SL +
Sbjct: 479 HAPVLAPPPPGSLCSEPHQGPGL-LLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQV 537
Query: 554 QDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNT 613
+ A + +H + + + L +L+ DSG P L + +C C G
Sbjct: 538 NVSHARLRPRH----QVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAA 593
Query: 614 TAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSH----LSSDEDEDMRDNVIK 669
LS GAL+ +L L+L+VLVLL+ R K L +D+RDNV+
Sbjct: 594 ALLAGGTGLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLN 653
Query: 670 YNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSE 729
Y+++GGGE+D +AYD+S LR G PP
Sbjct: 654 YDEQGGGEEDQDAYDISQLRHPTALSL--------------------PLGPPPL------ 687
Query: 730 RHSLPQGPPSPEPDFSV------FRDFISRKVALADGDLSVPPYDAFQTYAFEGADSPAA 783
R PQG P+P + DFI+ + AD D SVPPYD Y +EG S A
Sbjct: 688 RRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAG 747
Query: 784 SLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGH 819
+LSS+ S +QD+ YL WGPRF LA +Y GH
Sbjct: 748 TLSSILSSQGDEDQDYDYLRDWGPRFARLADMY-GH 782
>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
Length = 882
Score = 303 bits (776), Expect = 4e-82
Identities = 261/796 (32%), Positives = 376/796 (47%), Gaps = 90/796 (11%)
Query: 56 GAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGT----IFL 111
G R KR WV E G P + +I S+ D+ +G + Y+I+G+GA T +F+
Sbjct: 148 GLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDK-EGKVFYSITGQGADTPPVGVFI 206
Query: 112 IDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHG 171
I+ TG + E LDRE+ YTL + A N + +P E +I V D ND++P F
Sbjct: 207 IERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDP-MEILITVTDQNDNKPEFTQE 265
Query: 172 PYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLD------GEHHFTVDPKTGV 225
+ GSV E + GTSVM+V A+DADD +A + Y++L ++ FT++ TGV
Sbjct: 266 VFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGV 325
Query: 226 IRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFS 285
I LDRES Y +V+QA D+ G+ GLS + T I VTD NDNPP F Y+
Sbjct: 326 ISVVTTGLDRESFPTYTLVVQAADLQGE--GLSTTATAVITVTDTNDNPPIFNPTTYKGQ 383
Query: 286 IQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKR 345
+ E+ + +K D+D NT + + G F VTT+ + I+ K
Sbjct: 384 VPEN-EANVVITTLKVTDAD-APNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKG 441
Query: 346 LDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQE 405
LDFE++ + + + N V P L T A V V V DV+E P F PP +EV E
Sbjct: 442 LDFEAKQQYILHVAVTN--VVPFEVSLTT--STATVTVDVLDVNEAPIFVPPEKRVEVSE 497
Query: 406 DAQVGSLVGVVTARDPDA-ANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRET--- 461
D VG + TA++PD + + Y I R D +I+ DTGAI T LDRE
Sbjct: 498 DFGVGQEITSYTAQEPDTFMEQKITYRIWR--DTANWLEINPDTGAISTRAELDREDFEH 555
Query: 462 AGWHNITVLAMEADNHAQLS--RASLRIRILDVNDNPPELATPYEAAVCE-DAKPGQLIQ 518
T L + DN + ++ +L + + DVNDN P + P CE + KP Q
Sbjct: 556 VKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAP-IPEPRTIFFCERNPKP----Q 610
Query: 519 TISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLP 578
I+++D D P F L A +N IQ N + ++ + P
Sbjct: 611 VINIIDADLPPNTSPFTAELTHGASAN-----WTIQYN-----------DPTQESIILKP 654
Query: 579 ILVVDSGPPTL--------SSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIAL 630
+ ++ G + + T+ + CD G C V A P L L
Sbjct: 655 KMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGIL 714
Query: 631 --LVCVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSAL 688
++ +LIL++L+LL L R K L ED D RDNV Y++EGGGE+D + +D+S L
Sbjct: 715 GGILALLILILLLLLFLRRRAVVKEPLLPPED-DTRDNVYYYDEEGGGEEDQD-FDLSQL 772
Query: 689 -RSLYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSERHSLPQGPPSP-EPDFSV 746
R L E+ D + S+P+ P P PD
Sbjct: 773 HRGLDARPEVTRND------------------------VAPTLMSVPRYLPRPANPD--E 806
Query: 747 FRDFISRKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWG 806
+FI + AD D + PPYD+ + +EG+ S AASLSSL+S S +QD+ YL+ WG
Sbjct: 807 IGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWG 866
Query: 807 PRFRPLAALYAGHRGD 822
RF+ LA +Y G D
Sbjct: 867 NRFKKLADMYGGGEDD 882
>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
Length = 829
Score = 283 bits (724), Expect = 5e-76
Identities = 245/790 (31%), Positives = 365/790 (46%), Gaps = 90/790 (11%)
Query: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGT----IFLIDE 114
R KR WV V E G P + ++ S+ D D I Y+I+G GA + +F +++
Sbjct: 104 RHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDR-DTKIFYSITGPGADSPPEGVFAVEK 162
Query: 115 LTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYI 174
TG + + LDRE+ Y L A + +P + II V D ND +P+F +
Sbjct: 163 ETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISII-VTDQNDHKPKFTQDTFR 221
Query: 175 GSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHH------FTVDPKTGVIRT 228
GSV E GTSVMQV A+D DD Y + + YS+ E FT+ TG I
Sbjct: 222 GSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISV 281
Query: 229 AVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVT---DVNDNPPRFPQKMYQFS 285
LDRE Y + IQATDM G GSTT + V D NDN P F + Y+
Sbjct: 282 ISSGLDREKVPEYTLTIQATDMDGD-----GSTTTAVAVVEILDANDNAPMFDPQKYEAH 336
Query: 286 IQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKR 345
+ E+A +G V R+ D D + GD F +TT ++ + I+ +K
Sbjct: 337 VPENA-VGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKG 395
Query: 346 LDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQE 405
LDFE++ HT+ +E N+ P L T A + V V DV+E P F PPS ++EVQE
Sbjct: 396 LDFEAKNQHTLYVEVTNEA--PFVLKLPT--STATIVVHVEDVNEAPVFVPPSKVVEVQE 451
Query: 406 DAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGW- 464
G V V TA DPD N+ + Y I R D +D D+G + LDRE +
Sbjct: 452 GIPTGEPVCVYTAEDPDKENQKISYRILR--DPAGWLAMDPDSGQVTAVGTLDREDEQFV 509
Query: 465 ----HNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTI 520
+ + VLAM+ + +L + ++DVND+ P + P + +C + + Q +
Sbjct: 510 RNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGP-VPEPRQITICNQS---PVRQVL 565
Query: 521 SVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPIL 580
++ D+D F +L ++ + ++ + V F +QD + + +
Sbjct: 566 NITDKDLSPHTSPFQAQLTDDSDI---YWTAEVNEEGDTVVLSLKKF--LKQDTYDVHLS 620
Query: 581 VVDSGPPTLSSTGTLTIRICGCDSSGTIQSCN---TTAFVMAASLSPGALIALLVCVLIL 637
+ D G + IR CD G +++C F++ GA++ALL +L+L
Sbjct: 621 LSDHG----NKEQLTVIRATVCDCHGHVETCPGPWKGGFILPVL---GAVLALLFLLLVL 673
Query: 638 VVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGEL 697
LL++ +R K L ED D RDNV Y +EGGGE+D + YD++ L
Sbjct: 674 ----LLLVRKKRKIKEPLLLPED-DTRDNVFYYGEEGGGEEDQD-YDITQLHR------- 720
Query: 698 KGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSERH----SLPQGPPSP-EPDFSVFRDFIS 752
G + P+ L ++ P P P PD +FI
Sbjct: 721 -------------------GLEARPEVVLRNDVAPTIIPTPMYRPRPANPD--EIGNFII 759
Query: 753 RKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPL 812
+ A+ D + PPYD + +EG+ S AASLSSL S +S +QD+ YL+ WG RF+ L
Sbjct: 760 ENLKAANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKL 819
Query: 813 AALYAGHRGD 822
A +Y G D
Sbjct: 820 ADMYGGGEDD 829
>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
sapiens]
Length = 896
Score = 234 bits (597), Expect = 2e-61
Identities = 221/783 (28%), Positives = 346/783 (44%), Gaps = 52/783 (6%)
Query: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAG----TIFLIDE 114
R KR W + E G PL++ ++ SD+ + + + Y+ISG G +F I+
Sbjct: 132 RAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSISGRGVDKEPLNLFYIER 190
Query: 115 LTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYI 174
TG++ +DRE+ + L A A A + I+V+D ND+ P F Y
Sbjct: 191 DTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRVEDENDNHPVFTEAIYN 249
Query: 175 GSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHH----FTVDPKTGVIRTAV 230
V E S GT+V V A+D D+P RL YS+L F+V P TGVI T
Sbjct: 250 FEVLESSRPGTTVGVVCATDRDEPDT-MHTRLKYSILQQTPRSPGLFSVHPSTGVITTVS 308
Query: 231 PDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESA 290
LDRE ++Y ++++ DM GQ GL G++T I VTD NDN P F Q Y+ ++E+A
Sbjct: 309 HYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENA 368
Query: 291 PIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFES 350
+ R+ ED D+ + + + FK++TD +T E ++ V K L++E
Sbjct: 369 -FNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEE 427
Query: 351 QPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVG 410
+ + N+ R T ++A+V V V D+DE PE P + + ++E+ VG
Sbjct: 428 NRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVG 487
Query: 411 SLVGVVTARDPDAAN-RPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETA----GWH 465
S + A DP+ N +RY + D ID +G+I+T K LDRE +
Sbjct: 488 SKINGYKAYDPENRNGNGLRY--KKLHDPKGWITIDEISGSIITSKILDREVETPKNELY 545
Query: 466 NITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDR 525
NITVLA++ D+ + +L + I DVNDNPPE+ Y +C KP I VD
Sbjct: 546 NITVLAIDKDDRS--CTGTLAVNIEDVNDNPPEILQEY-VVIC---KPKMGYTDILAVDP 599
Query: 526 DEPQGGHRFYFRLVPEAPS-NPHFSLLDIQDNTAAV-HTQHVGFNRQEQDVFFLPILVVD 583
DEP G FYF L +P + +SL + D A + + ++ GF + +PI V D
Sbjct: 600 DEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQE-----YTIPITVKD 654
Query: 584 SGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLL 643
++T L + +C C C T+ L A++A+L+ + +L ++L
Sbjct: 655 RAGQ--AATKLLRVNLCECTHP---TQCRATSRSTGVILGKWAILAILLGIALLFSVLLT 709
Query: 644 ILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGG 703
++ ED ++ +I + G ++ A + G G
Sbjct: 710 LVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGS 769
Query: 704 GSAGGGAG--GGSGGGAGSPPQAHLPSERHSLPQ-GPPSPEPD-----FSVFRDFISRKV 755
G GG GG + H+L E D +S + F ++
Sbjct: 770 GMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRL 829
Query: 756 A-----LADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFR 810
+ +P D TY +EG SPA S+ E +L++ P+F
Sbjct: 830 GEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGC--CSEKQEEDGLDFLNNLEPKFI 887
Query: 811 PLA 813
LA
Sbjct: 888 TLA 890
>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
sapiens]
Length = 839
Score = 232 bits (592), Expect = 9e-61
Identities = 187/602 (31%), Positives = 291/602 (48%), Gaps = 37/602 (6%)
Query: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAG----TIFLIDE 114
R KR W + E G PL++ ++ SD+ + + + Y+ISG G +F I+
Sbjct: 132 RAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSISGRGVDKEPLNLFYIER 190
Query: 115 LTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYI 174
TG++ +DRE+ + L A A A + I+V+D ND+ P F Y
Sbjct: 191 DTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRVEDENDNHPVFTEAIYN 249
Query: 175 GSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHH----FTVDPKTGVIRTAV 230
V E S GT+V V A+D D+P RL YS+L F+V P TGVI T
Sbjct: 250 FEVLESSRPGTTVGVVCATDRDEPDT-MHTRLKYSILQQTPRSPGLFSVHPSTGVITTVS 308
Query: 231 PDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESA 290
LDRE ++Y ++++ DM GQ GL G++T I VTD NDN P F Q Y+ ++E+A
Sbjct: 309 HYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENA 368
Query: 291 PIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFES 350
+ R+ ED D+ + + + FK++TD +T E ++ V K L++E
Sbjct: 369 -FNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEE 427
Query: 351 QPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVG 410
+ + N+ R T ++A+V V V D+DE PE P + + ++E+ VG
Sbjct: 428 NRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVG 487
Query: 411 SLVGVVTARDPDAAN-RPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETA----GWH 465
S + A DP+ N +RY + D ID +G+I+T K LDRE +
Sbjct: 488 SKINGYKAYDPENRNGNGLRY--KKLHDPKGWITIDEISGSIITSKILDREVETPKNELY 545
Query: 466 NITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDR 525
NITVLA++ D+ + +L + I DVNDNPPE+ Y +C KP I VD
Sbjct: 546 NITVLAIDKDDRS--CTGTLAVNIEDVNDNPPEILQEY-VVIC---KPKMGYTDILAVDP 599
Query: 526 DEPQGGHRFYFRLVPEAPS-NPHFSLLDIQDNTAAV-HTQHVGFNRQEQDVFFLPILVVD 583
DEP G FYF L +P + +SL + D A + + ++ GF + +PI V D
Sbjct: 600 DEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQE-----YTIPITVKD 654
Query: 584 SGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLL 643
++T L + +C C C T+ L A++A+L+ + +L ++L
Sbjct: 655 RAGQ--AATKLLRVNLCECTHP---TQCRATSRSTGVILGKWAILAILLGIALLFSVLLT 709
Query: 644 IL 645
++
Sbjct: 710 LV 711
>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
Length = 713
Score = 231 bits (590), Expect = 2e-60
Identities = 196/607 (32%), Positives = 301/607 (49%), Gaps = 48/607 (7%)
Query: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGT----IFLIDE 114
R KR V + + E P VGK+ DSD + + K+ ++G+G IF I+E
Sbjct: 135 RQKRSIVVSPILIPENQRQPFPRDVGKV-VDSDRPERS-KFRLTGKGVDQEPKGIFRINE 192
Query: 115 LTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYI 174
TG + LDRE Y L + D + LE + V D ND+ P F GPYI
Sbjct: 193 NTGSVSVTRTLDREVIAVYQLFVETTD-VNGKTLEGPVPLEVIVIDQNDNRPIFREGPYI 251
Query: 175 GSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLD------GEHHFTVDPKTGVIRT 228
G V E SPTGT+VM++ A DADDP +A L Y++ + F +DP+ G I T
Sbjct: 252 GHVMEGSPTGTTVMRMTAFDADDPAT-DNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVT 310
Query: 229 AVPD--LDRESQE--RYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQF 284
V LDRE+ E +YE++I+A DMAG GL+G+ T TI++ D ND+ P+F +K +Q
Sbjct: 311 VVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQA 370
Query: 285 SIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQK 344
+++E A +G V + ED D + + G F++ T+ T E ++ V K
Sbjct: 371 TVEEGA-VGVIV-NLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVK 428
Query: 345 RLDFESQPVHTVILEALNKFVDPRFADLGTF-RDQAIVRVAVTDVDEPPEFRPPSGLLEV 403
LD+E HT++++ N+ DP D+ A V + V DV+E P F P ++
Sbjct: 429 PLDYEISAFHTLLIKVENE--DPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTR 486
Query: 404 QEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETA 462
QED VGS++ V A DPD+ ++ +RY++ + D +I+ G + T LDRE+
Sbjct: 487 QEDLSVGSVLLTVNATDPDSLQHQTIRYSVYK--DPAGWLNINPINGTVDTTAVLDRESP 544
Query: 463 ----GWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQ 518
+ LA+++ N +L I + DVNDN P P A VC+DAK ++
Sbjct: 545 FVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAP-FIYPTVAEVCDDAKNLSVV- 602
Query: 519 TISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLP 578
+ D+D F F + +A + + + I +NT A+ + N+ + LP
Sbjct: 603 ILGASDKDLHPNTDPFKFEIHKQAVPDKVWKISKI-NNTHALVSLLQNLNKAN---YNLP 658
Query: 579 ILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILV 638
I+V DSG P +++ L +++C C +S CN + GAL L VL+L
Sbjct: 659 IMVTDSGKPPMTNITDLRVQVCSCRNSKV--DCN----------AAGALRFSLPSVLLLS 706
Query: 639 VLVLLIL 645
+ L L
Sbjct: 707 LFSLACL 713
>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
Length = 840
Score = 218 bits (555), Expect = 2e-56
Identities = 191/660 (28%), Positives = 317/660 (48%), Gaps = 52/660 (7%)
Query: 46 APGARQDGALGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEG 105
+P R R KR W ++E G P +V +I SD+ + + I Y+ISG G
Sbjct: 118 SPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTIFYSISGPG 176
Query: 106 AG----TIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDI 161
+F I++ TGDI +DRE+ + L A A E IIK++D
Sbjct: 177 VDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATT-ADGYAPEYPLPLIIKIEDD 235
Query: 162 NDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVL----DGEHHF 217
ND+ P F H I +V E +GTSV +V A+D D+P RL Y +L D HF
Sbjct: 236 NDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDT-LHTRLKYKILQQIPDHPKHF 294
Query: 218 TVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRF 277
++ P TGVI T P LDRE + Y+++++ DM GQ GL + T+TI + D NDNPP F
Sbjct: 295 SIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSF 354
Query: 278 PQKMYQFSIQESAPIGTAVGRVKAEDSDVGE--NTDMTYHLKDESSSGGDVFKVTTDSDT 335
+ Y ++E+ I + R+K +D D+ ++ Y + + +G F ++TD +T
Sbjct: 355 TETSYVTEVEENR-IDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGN--FIISTDPNT 411
Query: 336 QEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAI----VRVAVTDVDEP 391
E ++ V K L++E V+ ++ + + +F+ + + + V V + D DE
Sbjct: 412 NEGVLCVVKPLNYE---VNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEG 468
Query: 392 PEFRPPSGLLEVQEDAQVGSLVGVVTARDPD-AANRPVRYAIDRESDLDQIFDIDADTGA 450
PE PP +++ Q+ G + A DP+ ++ +RY + D D F+I+ TG
Sbjct: 469 PECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGD 526
Query: 451 IVTGKGLDRETA----GWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAA 506
+ T K LDRE+ +NI+V+A++A + +L + + D ND+ P++ E
Sbjct: 527 LRTLKVLDRESKFVKNNQYNISVVAVDAVGRS--CTGTLVVHLDDYNDHAPQI--DKEVT 582
Query: 507 VCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVG 566
+C++ + + VD D P+ G F F L A N + ++ +D A+ Q
Sbjct: 583 ICQN---NEDFAVLKPVDPDGPENGPPFQFFLDNSASKNWN---IEEKDGKTAILRQ--- 633
Query: 567 FNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCD--SSGTIQSCNTTAFVMAASLSP 624
RQ D + + + L +T LT+R+C C S ++ +T L
Sbjct: 634 --RQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGR 691
Query: 625 GALIALLV--CVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEA 682
A++A+++ +L+ ++ +T +R K D + N+I N EG GE+ TEA
Sbjct: 692 WAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPED---IAQQNLIVSNTEGPGEEVTEA 748
>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
sapiens]
Length = 894
Score = 218 bits (555), Expect = 2e-56
Identities = 191/660 (28%), Positives = 317/660 (48%), Gaps = 52/660 (7%)
Query: 46 APGARQDGALGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEG 105
+P R R KR W ++E G P +V +I SD+ + + I Y+ISG G
Sbjct: 118 SPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTIFYSISGPG 176
Query: 106 AG----TIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDI 161
+F I++ TGDI +DRE+ + L A A E IIK++D
Sbjct: 177 VDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATT-ADGYAPEYPLPLIIKIEDD 235
Query: 162 NDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVL----DGEHHF 217
ND+ P F H I +V E +GTSV +V A+D D+P RL Y +L D HF
Sbjct: 236 NDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDT-LHTRLKYKILQQIPDHPKHF 294
Query: 218 TVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRF 277
++ P TGVI T P LDRE + Y+++++ DM GQ GL + T+TI + D NDNPP F
Sbjct: 295 SIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSF 354
Query: 278 PQKMYQFSIQESAPIGTAVGRVKAEDSDVGE--NTDMTYHLKDESSSGGDVFKVTTDSDT 335
+ Y ++E+ I + R+K +D D+ ++ Y + + +G F ++TD +T
Sbjct: 355 TETSYVTEVEENR-IDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGN--FIISTDPNT 411
Query: 336 QEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAI----VRVAVTDVDEP 391
E ++ V K L++E V+ ++ + + +F+ + + + V V + D DE
Sbjct: 412 NEGVLCVVKPLNYE---VNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEG 468
Query: 392 PEFRPPSGLLEVQEDAQVGSLVGVVTARDPD-AANRPVRYAIDRESDLDQIFDIDADTGA 450
PE PP +++ Q+ G + A DP+ ++ +RY + D D F+I+ TG
Sbjct: 469 PECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGD 526
Query: 451 IVTGKGLDRETA----GWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAA 506
+ T K LDRE+ +NI+V+A++A + +L + + D ND+ P++ E
Sbjct: 527 LRTLKVLDRESKFVKNNQYNISVVAVDAVGRS--CTGTLVVHLDDYNDHAPQI--DKEVT 582
Query: 507 VCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVG 566
+C++ + + VD D P+ G F F L A N + ++ +D A+ Q
Sbjct: 583 ICQN---NEDFAVLKPVDPDGPENGPPFQFFLDNSASKNWN---IEEKDGKTAILRQ--- 633
Query: 567 FNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCD--SSGTIQSCNTTAFVMAASLSP 624
RQ D + + + L +T LT+R+C C S ++ +T L
Sbjct: 634 --RQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGR 691
Query: 625 GALIALLV--CVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEA 682
A++A+++ +L+ ++ +T +R K D + N+I N EG GE+ TEA
Sbjct: 692 WAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPED---IAQQNLIVSNTEGPGEEVTEA 748
>gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo
sapiens]
Length = 901
Score = 207 bits (527), Expect = 3e-53
Identities = 220/789 (27%), Positives = 346/789 (43%), Gaps = 59/789 (7%)
Query: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAG----TIFLIDE 114
R KR W ++E G PL++ ++ SD+ + + I Y+I G G +F ++
Sbjct: 132 RAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQ-NYTIYYSIRGPGVDQEPRNLFYVER 190
Query: 115 LTGDIHAMERLDREQKTFYTLRAQAR--DRATNRLLEPESEFIIKVQDINDSEPRFLHGP 172
TG+++ +DREQ + + A A D T L P IIK++D ND+ P F
Sbjct: 191 DTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLP---LIIKIEDENDNYPIFTEET 247
Query: 173 YIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLD----GEHHFTVDPKTGVIRT 228
Y ++ E GT+V QV A+D D+P RL YS++ F++ P TGVI T
Sbjct: 248 YTFTIFENCRVGTTVGQVCATDKDEPDT-MHTRLKYSIIGQVPPSPTLFSMHPTTGVITT 306
Query: 229 AVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQE 288
LDRE ++Y++ I+ DM GQ GL ++T I + DVND+ P F + Y S++E
Sbjct: 307 TSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEE 366
Query: 289 SAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDF 348
+ + + RV ED D+ + + + FK+ TD+ T E ++ V K L++
Sbjct: 367 NT-VDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNY 425
Query: 349 ESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQ 408
E + + + +N+ R A + A V V V D DE PE PP + ++E+A+
Sbjct: 426 EEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAE 485
Query: 409 VGSLVGVVTARDPDA-ANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETA----G 463
VG+ A DP+ ++ +RY + +D ID +TG+I + LDRE G
Sbjct: 486 VGTTSNGYKAYDPETRSSSGIRY--KKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNG 543
Query: 464 WHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVV 523
+NITVLA +D + +L I + DVNDN P + P + + KP I V
Sbjct: 544 IYNITVLA--SDQGGRTCTGTLGIILQDVNDNSPFI--PKKTVII--CKPTMSSAEIVAV 597
Query: 524 DRDEPQGGHRFYFRLVPEAPS-NPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVV 582
D DEP G F F L + L I D A + Q N + +PI V
Sbjct: 598 DPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQ----NDPPFGSYVVPITVR 653
Query: 583 DSGPPTLSSTGTLTIRICGC-DSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLV 641
D +SS +L + +C C + + L A++A+L+ + +L ++
Sbjct: 654 DR--LGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCIL 711
Query: 642 LLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGD 701
++ D+ + N+I N E G D + Y + + +G
Sbjct: 712 FTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPG--DDKVYSANGFTTQTVGASAQGVC 769
Query: 702 GGGSAGGGAGGGS-----GGGAGSPPQAHLPSERHSLPQ-GPPSPEPD-----FSVFRDF 750
G +G GG GG + H+L E D +S + F
Sbjct: 770 GTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSF 829
Query: 751 ----ISRKVALADGDLS-VPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQD-FAYLSS 804
+ KV L + D + D TY +EG S A S+ S E+D +L +
Sbjct: 830 TQPRLGEKVYLCNQDENHKHAQDYVLTYNYEGRGSVAGSVGCC---SERQEEDGLEFLDN 886
Query: 805 WGPRFRPLA 813
P+FR LA
Sbjct: 887 LEPKFRTLA 895
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 206 bits (524), Expect = 7e-53
Identities = 172/539 (31%), Positives = 267/539 (49%), Gaps = 30/539 (5%)
Query: 94 DGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESE 153
+G IKY+IS IF I+ TG + + LD E + + A D S
Sbjct: 3121 NGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCS- 3179
Query: 154 FIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDG 213
+ V D+ND+ P FL Y +V E +P+GT+V+ + A+DAD G++A + Y+V
Sbjct: 3180 VTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADS---GTNAVIAYTVQSS 3236
Query: 214 EHH-FTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVND 272
+ F +DP TGVI T LD E+++ Y + ++A ++ + TV I + N+
Sbjct: 3237 DSDLFVIDPNTGVITTQ-GFLDFETKQSYHLTVKAFNVPDE--ERCSFATVNIQLKGTNE 3293
Query: 273 NPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTD 332
PRF K+Y F I E+AP GT VG V A D D+G + ++ Y + S G F++
Sbjct: 3294 YVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKG--FQI--- 3348
Query: 333 SDTQEAIIVVQKRLDFESQPVHTVILEALNK-FVDPRFADLGTFRDQAIVRVAVTDVDEP 391
+ + I V LD E + V L+ L K F R AD+ D+ V V V D ++P
Sbjct: 3349 -NKKTGQIYVSGILDREKE--ERVSLKVLAKNFGSIRGADI----DEVTVNVTVLDANDP 3401
Query: 392 PEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQ-IFDIDADTGA 450
P F +++ E +G+ V V+A D D+ R++ S + F I+ TG
Sbjct: 3402 PIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQ 3461
Query: 451 IVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCED 510
I LDRET +N++VLA+++ + ASL + + D+NDN P L T E V E+
Sbjct: 3462 ITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPML-TVSEGEVMEN 3520
Query: 511 AKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQ 570
+PG L+ T+ D D P F + L+ P+ +FSL +TA V + +R+
Sbjct: 3521 KRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSL-----STAGVLSTTREIDRE 3575
Query: 571 EQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFV-MAASLSPGALI 628
+ F+L ++ DSG P +SSTGT+ I + + QS FV +L PG ++
Sbjct: 3576 QIADFYLSVVTKDSGVPQMSSTGTVHITVID-QNDNPSQSRTVEIFVNYYGNLFPGGIL 3633
Score = 180 bits (456), Expect = 5e-45
Identities = 158/550 (28%), Positives = 262/550 (47%), Gaps = 47/550 (8%)
Query: 69 FFVVEEYTGTEPLYVGKIHS-DSDEG-DGAIKYTISGEGAGTIFLIDELTGDIHAMERLD 126
+F E+ G+ +VGK+ + D D G +G ++Y+ E F + ++G+I + D
Sbjct: 1108 YFEEEQRAGS---FVGKVSAVDKDFGPNGEVRYSF--EMVQPDFELHAISGEITNTHQFD 1162
Query: 127 REQ------KTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAEL 180
RE ++ A D+ + L+ ++ + ++DIND+ P+FL Y +++E
Sbjct: 1163 RESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISES 1222
Query: 181 SPTGTSVMQVMASDADDPTYGSSARLVYSVLDG--EHHFTVDPKTGVIRTAVPDLDRESQ 238
+ T V++V ASD D+ G++ + YS++ G E F +D +G + T + LD E+
Sbjct: 1223 AANLTQVLRVSASDVDE---GNNGLIHYSIIKGNEERQFAIDSTSGQV-TLIGKLDYEAT 1278
Query: 239 ERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGR 298
Y +VIQA D +G + L+ + T+ I + D NDN P FP+ + E+ IG V
Sbjct: 1279 PAYSLVIQAVD-SGTIP-LNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSS 1336
Query: 299 VKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVIL 358
V A DSD G+N D+ Y + ++ G F ++ ++ + I + K+LDFE+Q ++ + +
Sbjct: 1337 VTATDSDSGDNADLYYSITGTNNHG--TFSISPNTGS----IFLAKKLDFETQSLYKLNI 1390
Query: 359 EALNKFVDPRFADLGTFRDQAIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVT 417
A ++ PR + + V + V D D PP F P + E+ +G+ V VT
Sbjct: 1391 TAKDQGRPPRSSTMS-------VVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVT 1443
Query: 418 ARDPDA-ANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADN 476
A DPDA N + Y I ++ F ID G I T +DRE A +TV A +
Sbjct: 1444 AHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAV 1503
Query: 477 HAQLSRASLR---IRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHR 533
+ R +L+ I + D+NDN P + A A G ++ TI D DE G
Sbjct: 1504 PIETRRYALKNVTILVTDLNDNVPMFISQNALAADPSAVIGSVLTTIMAADPDEGANGEI 1563
Query: 534 FYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTG 593
Y + + + ++D V + V Q ++ L + D GP ST
Sbjct: 1564 EYEIINGDTDT----FIVDRYSGDLRVASALV----PSQLIYNLIVSATDLGPERRKSTT 1615
Query: 594 TLTIRICGCD 603
LTI + G D
Sbjct: 1616 ELTIILQGLD 1625
Score = 170 bits (431), Expect = 4e-42
Identities = 162/538 (30%), Positives = 254/538 (47%), Gaps = 43/538 (7%)
Query: 70 FVVEEYTGTEPLYVGKIHSDSDEG-DGAIKYTISGEGAGTIFLIDELTGDIHAMERLDRE 128
F + E T L + +D D G +G I Y ++ + IF ++ +TG + LD E
Sbjct: 1848 FDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYE 1907
Query: 129 QKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVM 188
+ +Y L +A D + D+ND+ P F Y S+ E P G++V+
Sbjct: 1908 VQQYYILTVRAEDGGGQFTT---IRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVL 1964
Query: 189 QVMASDADDPTYGSSARLVYSVLDGEH--HFTVDPKTGVIRTAVPDLDRESQERYEVVIQ 246
+DADD G +++L YS+ G+ FTVD K GV++ + LDRESQ Y +V+Q
Sbjct: 1965 VFNVTDADD---GINSQLTYSIASGDSLGQFTVD-KNGVLKV-LKALDRESQSFYNLVVQ 2019
Query: 247 ATDMAGQLGGLSGSTT-VTIVVTDVNDNPPRF--PQKMYQFSIQESAPIGTAVGRVKAED 303
D+ ST V+I++ DVNDNPP F P+ Y I E+ PI T V + +A D
Sbjct: 2020 VHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY---IPENTPIDTVVFKAQATD 2076
Query: 304 SDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNK 363
D G N+ + Y L + G+ F + T + + + LD E +T+ + A +K
Sbjct: 2077 PDSGPNSYIEYTLLNPL---GNKFSI----GTIDGEVRLTGELDREEVSNYTLTVVATDK 2129
Query: 364 FVDPRFADLGTFRDQAIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPD 422
+ V V V D+ D P F +E+ E+ G+ + V A D D
Sbjct: 2130 -------GQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGD 2182
Query: 423 -AANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLS 481
N VRY I + +Q F ID+ TGAI K LDRE +++TV A + + +
Sbjct: 2183 EGTNGQVRYGIVN-GNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTD 2241
Query: 482 RASLRIRILDVNDNPPELA-TPYEAAVCEDAKPGQLIQTI-SVVDRDEPQGGHRFYFRLV 539
+++ I +LD+ND P +PY V E+ G L +TI VV RD+ +G + ++
Sbjct: 2242 TSTVSIVLLDINDFVPVFELSPYSVNVPENL--GTLPRTILQVVARDDDRGSNSKLSYVL 2299
Query: 540 PEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTI 597
+ F+L + + +R+ ++ F L I DSG P L+ TGT+ +
Sbjct: 2300 FGGNEDNAFTL-----SASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINV 2352
Score = 168 bits (426), Expect = 2e-41
Identities = 153/532 (28%), Positives = 241/532 (45%), Gaps = 39/532 (7%)
Query: 72 VEEYTGTEPLYVGKIHSDSDEGDGA-IKYTISGEGAGTIFLIDELTGDIHAMERLDREQK 130
VEE G + D+DEG A + YTI GA F ID +GD+ A RLDRE++
Sbjct: 1749 VEENIGDGSKIMQLTAMDADEGANALVTYTIIS-GADDSFRIDPESGDLIATRRLDRERR 1807
Query: 131 TFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQV 190
+ Y+L RA + L + I V D+ND P+F Y + E + G+ V +
Sbjct: 1808 SKYSLLV----RADDGLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAI 1863
Query: 191 MASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDM 250
+A+D D G +V + D + F ++P TGV LD E Q+ Y + ++A D
Sbjct: 1864 LATDDDSGVNGEITYIV-NEDDEDGIFFLNPITGVF-NLTRLLDYEVQQYYILTVRAEDG 1921
Query: 251 AGQLGGLSGSTTVTIV--VTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGE 308
GQ TT+ + + DVNDNPP F Y S+ E+ P+G+ V D+D G
Sbjct: 1922 GGQF------TTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGI 1975
Query: 309 NTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPR 368
N+ +TY + +SG + + T D + ++ V K LD ESQ + ++++ + P
Sbjct: 1976 NSQLTYSI----ASGDSLGQFTVD---KNGVLKVLKALDRESQSFYNLVVQVHDLPQIP- 2027
Query: 369 FADLGTFRDQAIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAA-NR 426
F A V + + DV D PP F P L + E+ + ++V A DPD+ N
Sbjct: 2028 ---ASRFTSTAQVSIILLDVNDNPPTFLSPK-LTYIPENTPIDTVVFKAQATDPDSGPNS 2083
Query: 427 PVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLR 486
+ Y + + L F I G + LDRE + +TV+A + + S +
Sbjct: 2084 YIEYTL--LNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVV 2141
Query: 487 IRILDVNDNPPELATP-YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSN 545
+ +LD+NDN P A Y+ + E+ G I + D DE G Y + +N
Sbjct: 2142 VMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYG--IVNGNTN 2199
Query: 546 PHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTI 597
F + D+ T +R++ + L + D G + T T++I
Sbjct: 2200 QEFRI----DSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSI 2247
Score = 166 bits (421), Expect = 6e-41
Identities = 158/559 (28%), Positives = 259/559 (46%), Gaps = 45/559 (8%)
Query: 88 SDSDEGDGA-IKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNR 146
+D+DEG A I+Y + EG T F +D TG I E LD E + Y+L QA DR
Sbjct: 275 ADADEGTNADIRYRLQDEG--TPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPS 332
Query: 147 LLEPESEFIIKVQDINDSEP--RFLHGPYIG---SVAELSPTGTSVMQVMASDADDPTYG 201
L +E +I++ D+ND++P +F + P SV E + GT V + +DAD P
Sbjct: 333 LTG-RAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPA-- 389
Query: 202 SSARLVYSVLDG--EHHFTVD----PKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLG 255
++ + +L G + HF V P +I+ A LDRE Y + + +D G
Sbjct: 390 ANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASA-LDRERIPSYNLTVSVSDNYGAPP 448
Query: 256 GL-----SGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENT 310
G S ++ I V D+ND+PP F Q++Y+ ++ E AP G+ V + A D D G N
Sbjct: 449 GAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNA 508
Query: 311 DMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFA 370
++ Y + S +G F ++ S LD E + + A ++ V P+ +
Sbjct: 509 NLRYSI--VSGNGLGWFHISEHSGL--VTTGSSGGLDRELASQIVLNISARDQGVHPKVS 564
Query: 371 DLGTFRDQAIVRVAVTDV-DEPPEFRPPSGL-LEVQEDAQVGSLVGVVTARDPDAA-NRP 427
A + V + DV DE P F P G + V E+A G+ + ++ A D D N
Sbjct: 565 -------YAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGT 617
Query: 428 VRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRI 487
VR+++ + F +D +G + T LDRE ++++ VLA + + Q S A + +
Sbjct: 618 VRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINV 677
Query: 488 RILDVNDNPPEL-ATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNP 546
+LD+NDN P Y A + E+ G I T+S D D G V + S
Sbjct: 678 SLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNG------TVKYSISAG 731
Query: 547 HFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSG 606
S + + + T+ + +R+E+ + L I+ D G + +TI + +
Sbjct: 732 DRSRFQVNAQSGVISTR-MALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNP 790
Query: 607 TIQSCNTTAFVMAASLSPG 625
+ S +FV+ +++ G
Sbjct: 791 PVFSQVAYSFVVFENVALG 809
Score = 163 bits (413), Expect = 5e-40
Identities = 151/547 (27%), Positives = 258/547 (47%), Gaps = 46/547 (8%)
Query: 82 YVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARD 141
+VG + + + + + I Y I+ +F I+++TG + +DRE+++FY L+ A
Sbjct: 811 HVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVA-- 868
Query: 142 RATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYG 201
+ + ++ I V+D+ND+ P FL +V E G S+ Q A D D+ G
Sbjct: 869 --SGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDE---G 923
Query: 202 SSARLVYSVLDGEHH-FTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGS 260
+ ++YS+ + F ++ K G I P LD + Y++ I A+DM + LS S
Sbjct: 924 VNGMVLYSLKQNPKNLFAINEKNGTISLLGP-LDVHAGS-YQIEILASDMG--VPQLSSS 979
Query: 261 TTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDES 320
+T+ V DVNDN P F Q Y+ ++ ES P+ + +V+A D D G N ++ Y + + +
Sbjct: 980 VILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGN 1039
Query: 321 SSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAI 380
+ GD F + D + ++ LD E Q + +++ A ++ V+P A +
Sbjct: 1040 T--GDAFGIFPDGQ-----LYIKSELDRELQDRYVLMVVASDRAVEPLSATVN------- 1085
Query: 381 VRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPD-AANRPVRYAIDRESDL 438
V V + DV D P F + +E+ + GS VG V+A D D N VRY+ + +
Sbjct: 1086 VTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEM---V 1142
Query: 439 DQIFDIDADTGAIVTGKGLDRET------AGWHNITVLAMEADNHAQL-SRASLRIRILD 491
F++ A +G I DRE+ + TV+A + L +A++ + + D
Sbjct: 1143 QPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKD 1202
Query: 492 VNDNPPE-LATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSL 550
+NDN P+ L Y+A + E A L Q + V D +G + + + F++
Sbjct: 1203 INDNAPKFLKDFYQATISESA--ANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAI 1260
Query: 551 LDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQS 610
D+T+ T + + + L I VDSG L+ST TL I I ++ T
Sbjct: 1261 ----DSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILD-ENDNTPSF 1315
Query: 611 CNTTAFV 617
+T FV
Sbjct: 1316 PKSTLFV 1322
Score = 159 bits (403), Expect = 8e-39
Identities = 135/452 (29%), Positives = 213/452 (47%), Gaps = 32/452 (7%)
Query: 89 DSDEG-DGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRL 147
D D G +G + Y I F I+ TG+I ++ LDRE+ + Y L ++ D+ +
Sbjct: 2694 DKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQ 2753
Query: 148 LEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLV 207
+ +I + D ND+ PRF + V E SP G +V +V SD D G +A
Sbjct: 2754 -STSVKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDED---IGINAISR 2808
Query: 208 YSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVV 267
YS++D FT++P TG I + P L+RE +RY + + A D G + ST VTI V
Sbjct: 2809 YSIMDASLPFTINPSTGDIVISRP-LNREDTDRYRIRVSAHD-----SGWTVSTDVTIFV 2862
Query: 268 TDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVF 327
TD+NDN PRF + Y E IG+ V +V A D D G N + Y +K +S + F
Sbjct: 2863 TDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQS----EYF 2918
Query: 328 KV--TTDSDTQEAIIVVQKRLDFESQPV--HTVILEALNKFVDPRFADLGTFRDQAIVRV 383
++ TT + I+ Q F + + H+ I+ + ++ + + V +
Sbjct: 2919 RINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDR-------GKPSLISETTVTI 2971
Query: 384 AVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPD--AANRPVRYAIDRESDLDQ 440
+ D D P+F V ++ +VG+ + VTA D N V Y I ++ L +
Sbjct: 2972 NIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGK 3031
Query: 441 IFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELA 500
F +D DTG I L + ITV A + N S+A++ I + + N + PE +
Sbjct: 3032 -FKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFS 3090
Query: 501 TPY-EAAVCEDAKPGQLIQTISVVDRDEPQGG 531
+ A + E G +++T+S DRD G
Sbjct: 3091 QSHMSATIPESHSIGSIVRTVSARDRDAAMNG 3122
Score = 159 bits (401), Expect = 1e-38
Identities = 142/509 (27%), Positives = 225/509 (44%), Gaps = 40/509 (7%)
Query: 107 GTIFLIDELTGDIHAMERLDREQKT-FYTLRAQARDRATNRLLEPESEFIIKVQDINDSE 165
G +F I TG I LDREQ Y + A +++T +E I +QDIND+
Sbjct: 1678 GRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNP 1737
Query: 166 PRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDG-EHHFTVDPKTG 224
P F +V E G+ +MQ+ A DAD+ G++A + Y+++ G + F +DP++G
Sbjct: 1738 PVFPTDMLDLTVEENIGDGSKIMQLTAMDADE---GANALVTYTIISGADDSFRIDPESG 1794
Query: 225 VIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQF 284
+ A LDRE + +Y ++++A D G S + I V+DVND+ P+F + +Y F
Sbjct: 1795 DL-IATRRLDRERRSKYSLLVRADD-----GLQSSDMRINITVSDVNDHTPKFSRPVYSF 1848
Query: 285 SIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQK 344
I E G+ V + A D D G N ++TY + ++ G T + + +
Sbjct: 1849 DIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPIT------GVFNLTR 1902
Query: 345 RLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDV-DEPPEFRPPSGLLEV 403
LD+E Q + + + A D G V + DV D PP F S +
Sbjct: 1903 LLDYEVQQYYILTVRA---------EDGGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSL 1953
Query: 404 QEDAQVGSLVGVVTARD-PDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETA 462
E+ VGS V V D D N + Y+I L Q F +D + G + K LDRE+
Sbjct: 1954 MENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQ-FTVDKN-GVLKVLKALDRESQ 2011
Query: 463 GWHNITVLAMEADN---HAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQT 519
++N+ V + S A + I +LDVNDNPP +P + E+ ++
Sbjct: 2012 SFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTPIDTVVFK 2071
Query: 520 ISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPI 579
D P G Y P FS+ I +R+E + L +
Sbjct: 2072 AQATD---PDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGE----LDREEVSNYTLTV 2124
Query: 580 LVVDSGPPTLSSTGTLTIRICGCDSSGTI 608
+ D G P+LSS+ + + + + + I
Sbjct: 2125 VATDKGQPSLSSSTEVVVMVLDINDNNPI 2153
Score = 155 bits (391), Expect = 2e-37
Identities = 132/450 (29%), Positives = 207/450 (46%), Gaps = 30/450 (6%)
Query: 88 SDSDEGDGA-IKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNR 146
+DSD GD A + Y+I+G F I TG I ++LD E ++ Y L A+D+
Sbjct: 1340 TDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPP 1399
Query: 147 LLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARL 206
S +I V+D ND+ P F G S+ E P GTSV+ V A D D G +
Sbjct: 1400 RSSTMS-VVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYT 1458
Query: 207 VYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGST-TVTI 265
+ + +HFT+D G I T ++DRE +E+ ++A D A + + VTI
Sbjct: 1459 IIQQMPRGNHFTIDEVKGTIYTNA-EIDREFANLFELTVKANDQAVPIETRRYALKNVTI 1517
Query: 266 VVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGD 325
+VTD+NDN P F + + SA IG+ + + A D D G N ++ Y + + +
Sbjct: 1518 LVTDLNDNVPMFISQN-ALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDTFI 1576
Query: 326 VFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAV 385
V + + D A++ SQ ++ +I+ A DLG R ++ + +
Sbjct: 1577 VDRYSGDLRVASALV--------PSQLIYNLIVSA---------TDLGPERRKSTTELTI 1619
Query: 386 TDVD-EPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAI----DRESDLDQ 440
+ P F P + ++E +G+ V + A P + PV Y I E + +
Sbjct: 1620 ILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGR 1679
Query: 441 IFDIDADTGAIVTGKGLDRET-AGWHNITVLAMEADN-HAQLSRASLRIRILDVNDNPPE 498
+F I TG I T LDRE A + + V A+E + RA + I + D+NDNPP
Sbjct: 1680 LFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPV 1739
Query: 499 LATP-YEAAVCEDAKPGQLIQTISVVDRDE 527
T + V E+ G I ++ +D DE
Sbjct: 1740 FPTDMLDLTVEENIGDGSKIMQLTAMDADE 1769
Score = 152 bits (384), Expect = 1e-36
Identities = 138/509 (27%), Positives = 229/509 (44%), Gaps = 34/509 (6%)
Query: 88 SDSDEG-DGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNR 146
SD D G +G I YTI+ G F I G ++ LDRE + Y L A DRA
Sbjct: 1021 SDKDSGANGEIAYTIAEGNTGDAFGIFP-DGQLYIKSELDRELQDRYVLMVVASDRAVEP 1079
Query: 147 LLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARL 206
L + +I ++D+ND+ P F Y E G+ V +V A D D +G + +
Sbjct: 1080 LSATVNVTVI-LEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKD---FGPNGEV 1135
Query: 207 VYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQER------YEVVIQATDMAGQLGGLSGS 260
YS + F + +G I T DRES R + + ATD G L
Sbjct: 1136 RYSFEMVQPDFELHAISGEI-TNTHQFDRESLMRRRGTAVFSFTVIATDQ-GIPQPLKDQ 1193
Query: 261 TTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDES 320
TV + + D+NDN P+F + YQ +I ESA T V RV A D D G N + Y +
Sbjct: 1194 ATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSI---- 1249
Query: 321 SSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAI 380
G + + DS + + ++ +LD+E+ P ++++++A++ P
Sbjct: 1250 IKGNEERQFAIDSTSGQVTLI--GKLDYEATPAYSLVIQAVDSGTIP-------LNSTCT 1300
Query: 381 VRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLD 439
+ + + D D P F + ++V E+ ++G LV VTA D D+ + Y ++
Sbjct: 1301 LNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNH 1360
Query: 440 QIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPEL 499
F I +TG+I K LD ET + + + A + + S S+ I + D NDNPP
Sbjct: 1361 GTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSF 1420
Query: 500 AT-PYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTA 558
++ E+ G + +++ D D G Y ++ + P HF++ +++
Sbjct: 1421 PPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSY-TIIQQMPRGNHFTIDEVK---G 1476
Query: 559 AVHTQHVGFNRQEQDVFFLPILVVDSGPP 587
++T + +R+ ++F L + D P
Sbjct: 1477 TIYT-NAEIDREFANLFELTVKANDQAVP 1504
Score = 146 bits (368), Expect = 9e-35
Identities = 146/522 (27%), Positives = 250/522 (47%), Gaps = 55/522 (10%)
Query: 88 SDSDEG-DGAIKYTI-SGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATN 145
+D+D+G + + Y+I SG+ G F +D+ G + ++ LDRE ++FY L Q D
Sbjct: 1969 TDADDGINSQLTYSIASGDSLGQ-FTVDK-NGVLKVLKALDRESQSFYNLVVQVHDLPQI 2026
Query: 146 RLLEPESEFIIKVQ------DINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPT 199
P S F Q D+ND+ P FL P + + E +P T V + A+D D
Sbjct: 2027 ----PASRFTSTAQVSIILLDVNDNPPTFL-SPKLTYIPENTPIDTVVFKAQATDPDS-- 2079
Query: 200 YGSSARLVYSVLDG-EHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLS 258
G ++ + Y++L+ + F++ G +R +LDRE Y + + ATD GQ LS
Sbjct: 2080 -GPNSYIEYTLLNPLGNKFSIGTIDGEVRLT-GELDREEVSNYTLTVVATDK-GQ-PSLS 2135
Query: 259 GSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKD 318
ST V ++V D+NDN P F Q +Y+ I E+ GT + +V A D D G N + Y + +
Sbjct: 2136 SSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVN 2195
Query: 319 ESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQ 378
+++ F++ D+ I V K LD E P + + ++A ++ PR D
Sbjct: 2196 GNTN--QEFRI----DSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPR-------TDT 2242
Query: 379 AIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSL---VGVVTARDPD-AANRPVRYAID 433
+ V + + D+ D P F + V E+ +G+L + V ARD D +N + Y +
Sbjct: 2243 STVSIVLLDINDFVPVFELSPYSVNVPEN--LGTLPRTILQVVARDDDRGSNSKLSYVLF 2300
Query: 434 RESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVN 493
++ D F + A +G + + LDRET + + A ++ + A ++ + + DVN
Sbjct: 2301 GGNE-DNAFTLSA-SGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVN 2358
Query: 494 DNPPELAT-PYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLD 552
DN P A+ Y + EDA G + ++ D D + ++ N F+
Sbjct: 2359 DNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNA------VIRIIGGNSQFT--- 2409
Query: 553 IQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGT 594
I +T + T + +R+ +D + L ++ D+G P S+ T
Sbjct: 2410 INPSTGQIITSAL-LDRETKDNYTLVVVCSDAGSPEPLSSST 2450
Score = 144 bits (362), Expect = 4e-34
Identities = 147/531 (27%), Positives = 230/531 (43%), Gaps = 49/531 (9%)
Query: 76 TGTEPLYVGKIHSDSDEGD-GAIKYTIS-GEGAGTIFLIDELTGDIHAMERLDREQKTFY 133
TGTE L + +D D GD G +++++ E F +D ++G + + LDRE++ FY
Sbjct: 598 TGTELLMLRA--TDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFY 655
Query: 134 TLRAQARDRATNRLLEPESEFI---IKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQV 190
+L A D + P+S + + DIND+ P F Y + E P G+ + V
Sbjct: 656 SLLVLATDLGS----PPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTV 711
Query: 191 MASDADDPTYGSSARLVYSVLDGEH-HFTVDPKTGVIRTAVPDLDRESQERYEVVIQATD 249
A+D P G++ + YS+ G+ F V+ ++GVI T + LDRE + Y++ I ATD
Sbjct: 712 SATD---PDLGTNGTVKYSISAGDRSRFQVNAQSGVISTRMA-LDREEKTAYQLQIVATD 767
Query: 250 MAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGEN 309
G L VTI V D DNPP F Q Y F + E+ +G VG V A D+ N
Sbjct: 768 -GGNLQS-PNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDL--N 823
Query: 310 TDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRF 369
++++Y + G T T +I D E Q + + + A
Sbjct: 824 SNISYLITTGDQKGMFAINQVTGQLTTANVI------DREEQSFYQLKVVASG------- 870
Query: 370 ADLGTFRDQAIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPD-AANRP 427
GT +V + V D+ D P F + V E+ Q G + A DPD N
Sbjct: 871 ---GTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGM 927
Query: 428 VRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRI 487
V Y++ + + +F I+ G I LD AG + I +LA + S L +
Sbjct: 928 VLYSL--KQNPKNLFAINEKNGTISLLGPLDVH-AGSYQIEILASDMGVPQLSSSVILTV 984
Query: 488 RILDVNDNPPEL-ATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNP 546
+ DVNDN P YE + E + D+D G Y + E +
Sbjct: 985 YVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAY--TIAEGNTGD 1042
Query: 547 HFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTI 597
F + D + ++ +R+ QD + L ++ D LS+T +T+
Sbjct: 1043 AFGI--FPDGQLYIKSE---LDRELQDRYVLMVVASDRAVEPLSATVNVTV 1088
Score = 139 bits (349), Expect = 1e-32
Identities = 135/483 (27%), Positives = 225/483 (46%), Gaps = 54/483 (11%)
Query: 77 GTEPLYVGKIHSDSDEGD--GAIK----YTISGEGAGTIFLIDELTGDIHAMERLDREQK 130
G EP V ++ + G G I+ +T + +F I+ TG ++ +DRE
Sbjct: 42 GAEPRQVFQVLEEQPPGTLVGTIQTRPGFTYRLSESHALFAINSSTGALYTTSTIDRESL 101
Query: 131 TFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQV 190
+ A +E + V+D+ND+ P F + + E S +G V+
Sbjct: 102 PSDVINLVVLSSAPTY----PTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILD 157
Query: 191 MASDADDPTYGSSARLVYSVLDGEH------HFTVDPK-TGVIRTAVPD--LDRESQERY 241
A+D+D + G R Y ++ G T++P G V LDRE +Y
Sbjct: 158 TATDSDIGSNGVDHRS-YRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQY 216
Query: 242 EVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKA 301
+++++ D G V + V D+NDNPP F YQ + E A +G++V +V A
Sbjct: 217 QLLVEVEDKGEPKR--RGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAA 274
Query: 302 EDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEAL 361
D+D G N D+ Y L+DE G F++ D + +I V++ LDFE++ +++ ++A+
Sbjct: 275 ADADEGTNADIRYRLQDE----GTPFQM----DPETGLITVREPLDFEARRQYSLTVQAM 326
Query: 362 NKFVDPRFADLGTFRDQAIVRVA-VTDVDEPPEFR---PPSGLLEVQEDAQVGSLVGVVT 417
++ V T R +A++++ V D D +FR S V E+AQVG++V ++T
Sbjct: 327 DRGVPSL-----TGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLT 381
Query: 418 ARDPD--AANRPVRYAIDRESDLDQIFDIDA----DTGAIVTGKGLDRETAGWHNITVLA 471
D D AAN + I ++ + F++ + + I LDRE +N+TV
Sbjct: 382 VTDADSPAANGNISVQILGGNE-QRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSV 440
Query: 472 ME-------ADNHAQLSRASLRIRILDVNDNPPELATP-YEAAVCEDAKPGQLIQTISVV 523
+ A A+ S ASL I + D+ND+PP + Y + E+A PG + IS
Sbjct: 441 SDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISAT 500
Query: 524 DRD 526
D D
Sbjct: 501 DGD 503
Score = 137 bits (345), Expect = 4e-32
Identities = 133/457 (29%), Positives = 209/457 (45%), Gaps = 46/457 (10%)
Query: 76 TGTEPLYVGKIHSDSDEG-DGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYT 134
TGT+ + V +D DEG +G ++Y I F ID +TG I + LDRE+ Y
Sbjct: 2169 TGTDIIQV--FAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYH 2226
Query: 135 LRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAE-LSPTGTSVMQVMAS 193
L QA DR + + + I+ + DIND P F PY +V E L +++QV+A
Sbjct: 2227 LTVQATDRGSTPRTDTSTVSIVLL-DINDFVPVFELSPYSVNVPENLGTLPRTILQVVAR 2285
Query: 194 DADDPTYGSSARLVYSVLDG--EHHFTVDP--KTGVIRTAVPDLDRESQERYEVVIQATD 249
D D GS+++L Y + G ++ FT+ + GV ++ LDRE++ER+ ++I ATD
Sbjct: 2286 DDDR---GSNSKLSYVLFGGNEDNAFTLSASGELGVTQS----LDRETKERFVLMITATD 2338
Query: 250 MAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGEN 309
L+G+ T+ ++V DVNDN P F K Y +I E AP GT V V A D+D +N
Sbjct: 2339 SGSP--ALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKN 2396
Query: 310 TDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRF 369
+ G F + + I+ LD E++ +T+++
Sbjct: 2397 AVI------RIIGGNSQFTINPSTGQ----IITSALLDRETKDNYTLVVVC--------- 2437
Query: 370 ADLGT---FRDQAIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPD-AA 424
+D G+ V V VTDV D PP F+ + + GS V VT D D
Sbjct: 2438 SDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGP 2497
Query: 425 NRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRAS 484
N + Y++ + + F ID GAI+ L+ A +V + + + +
Sbjct: 2498 NSELHYSLSGRN--SEKFHIDPLRGAIMAAGPLN--GASEVTFSVHVKDGGSFPKTDSTT 2553
Query: 485 LRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTIS 521
+ +R ++ D P A E+ L+ TI+
Sbjct: 2554 VTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTIT 2590
Score = 129 bits (325), Expect = 9e-30
Identities = 124/454 (27%), Positives = 202/454 (44%), Gaps = 35/454 (7%)
Query: 76 TGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTL 135
TGT+ L V SD+D A+ I G F I+ TG I LDRE K YTL
Sbjct: 2379 TGTDVLLVNA--SDADASKNAVIRIIGGNSQ---FTINPSTGQIITSALLDRETKDNYTL 2433
Query: 136 RAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDA 195
D + L + ++ V D+ND+ PRF H PY+ + + G+ V V +DA
Sbjct: 2434 VVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDA 2493
Query: 196 DDPTYGSSARLVYSVLD-GEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQL 254
D G ++ L YS+ F +DP G I A P L+ S+ + V ++ G
Sbjct: 2494 D---IGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGP-LNGASEVTFSVHVK----DGGS 2545
Query: 255 GGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTY 314
+ STTVT+ + D P+ K F E+ P+ + V + M+Y
Sbjct: 2546 FPKTDSTTVTVRFVNKADF-PKVRAKEQTFMFPENQPVSSLVTTITGSSL---RGEPMSY 2601
Query: 315 HLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGT 374
++ S + G+ F++ D + + + LDFE + V +EA + P
Sbjct: 2602 YI--ASGNLGNTFQI----DQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPP------- 2648
Query: 375 FRDQAIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAA-NRPVRYAI 432
F + + V DV D P F+ + E+ E+ ++ V+A D D+ N + Y I
Sbjct: 2649 FSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKIL-TVSAMDKDSGPNGQLDYEI 2707
Query: 433 DRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDV 492
+++ F I+ TG I + + LDRE + +T+ + + + +Q + + I ILD
Sbjct: 2708 -VNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDE 2766
Query: 493 NDNPPELATPYEAAVCEDAKPGQLIQTISVVDRD 526
NDN P + + A V E++ G + ++ D D
Sbjct: 2767 NDNAPRFSQIFSAHVPENSPLGYTVTRVTTSDED 2800
Score = 126 bits (316), Expect = 9e-29
Identities = 135/531 (25%), Positives = 223/531 (41%), Gaps = 41/531 (7%)
Query: 88 SDSDEG-DGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYT--------LRAQ 138
+D DEG +G + Y I + F I+ TG+I + L + T ++
Sbjct: 2897 TDPDEGSNGQVFYFIKSQSE--YFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVT 2954
Query: 139 ARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDP 198
+ DR L+ E+ I + D ND+ P+FL Y V + GT +++V A DD
Sbjct: 2955 SSDRGKPSLIS-ETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTA--IDDK 3011
Query: 199 TYGSSARLVYSVLDGEH--HFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGG 256
+G ++ + Y + + H F +D TG I A L + + + + + A D
Sbjct: 3012 DFGLNSEVEYFISNDNHLGKFKLDNDTGWISVA-SSLISDLNQNFFITVTAKDKGNP--P 3068
Query: 257 LSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHL 316
LS TV I VT+ N + P F Q +I ES IG+ V V A D D N + Y +
Sbjct: 3069 LSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSI 3128
Query: 317 KDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFR 376
+ G +F + + + I+ + K LD+E H + + A++ R
Sbjct: 3129 SSGNEEG--IFAINSST----GILTLAKALDYELCQKHEMTISAIDGGWVAR-------T 3175
Query: 377 DQAIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRE 435
V V V DV D P F V E+A G+ V + A D D+ V +
Sbjct: 3176 GYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQS 3235
Query: 436 SDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDN 495
SD D +F ID +TG I T LD ET +++TV A + + S A++ I++ N+
Sbjct: 3236 SDSD-LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEY 3294
Query: 496 PPELATP-YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQ 554
P + Y + E A G ++ + DRD G Y N I
Sbjct: 3295 VPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIF-----GNSRKKGFQIN 3349
Query: 555 DNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSS 605
T ++ + +R++++ L +L + G + +T+ + D++
Sbjct: 3350 KKTGQIYVSGI-LDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAN 3399
Score = 81.6 bits (200), Expect = 3e-15
Identities = 126/523 (24%), Positives = 206/523 (39%), Gaps = 51/523 (9%)
Query: 88 SDSDEGDGA-IKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNR 146
+D+D G + + Y++SG + F ID L G I A L+ + T +D +
Sbjct: 2491 TDADIGPNSELHYSLSGRNSEK-FHIDPLRGAIMAAGPLNGASEV--TFSVHVKDGGS-- 2545
Query: 147 LLEPESEFIIKVQDINDSE-PRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSAR 205
+ V+ +N ++ P+ E P + V + GSS R
Sbjct: 2546 -FPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTIT---------GSSLR 2595
Query: 206 ---LVYSVLDGE--HHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGS 260
+ Y + G + F +D TG + + P LD E ++Y V I+A D G S
Sbjct: 2596 GEPMSYYIASGNLGNTFQIDQLTGQVSISQP-LDFEKIQKYVVWIEARD--GGFPPFSSY 2652
Query: 261 TTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDES 320
+ I V DVNDN P F + + I E+ + V A D D G N + Y + + +
Sbjct: 2653 EKLDITVLDVNDNAPIFKEDPFISEILENLS-PRKILTVSAMDKDSGPNGQLDYEIVNGN 2711
Query: 321 SSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAI 380
F + + ++ + LD E + + +++ +D G+
Sbjct: 2712 MENS--FSINHATGEIRSV----RPLDREKVSHYVLTIKS---------SDKGSPSQSTS 2756
Query: 381 VRVAVTDVDEPPEFRPPSGLLE--VQEDAQVGSLVGVVTARDPDAA-NRPVRYAIDRESD 437
V+V + +DE S + V E++ +G V VT D D N RY+I D
Sbjct: 2757 VKVMINILDENDNAPRFSQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSI---MD 2813
Query: 438 LDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPP 497
F I+ TG IV + L+RE + I V A ++ + I + D+NDN P
Sbjct: 2814 ASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDS---GWTVSTDVTIFVTDINDNAP 2870
Query: 498 ELA-TPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDN 556
+ T Y E + G + + D DE G FYF + + +I +
Sbjct: 2871 RFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNK 2930
Query: 557 TAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRI 599
+ GF+ + + D G P+L S T+TI I
Sbjct: 2931 QILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINI 2973
Score = 66.6 bits (161), Expect = 9e-11
Identities = 63/231 (27%), Positives = 92/231 (39%), Gaps = 8/231 (3%)
Query: 77 GTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLR 136
GT +V SDS Y I F I+ TG I LDRE Y L
Sbjct: 3420 GTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLS 3479
Query: 137 AQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDAD 196
A D T S ++ ++DIND+ P G V E GT VM + ++D D
Sbjct: 3480 VLAVDSGTPSATGSAS-LLVTLEDINDNGPMLTVSE--GEVMENKRPGTLVMTLQSTDPD 3536
Query: 197 -DPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLG 255
P G + S +F++ T + + ++DRE + + + D +
Sbjct: 3537 LPPNQGPFTYYLLSTGPATSYFSL--STAGVLSTTREIDREQIADFYLSVVTKDSG--VP 3592
Query: 256 GLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDV 306
+S + TV I V D NDNP + + + G +G VK +D DV
Sbjct: 3593 QMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDV 3643
Score = 65.5 bits (158), Expect = 2e-10
Identities = 85/368 (23%), Positives = 148/368 (40%), Gaps = 52/368 (14%)
Query: 284 FSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQ 343
F + E P GT VG ++ TY L + + +F + + + +
Sbjct: 49 FQVLEEQPPGTLVGTIQTRPG-------FTYRLSESHA----LFAINSSTGA----LYTT 93
Query: 344 KRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDV-DEPPEFRPPSGLLE 402
+D ES P + L L+ T+ + VRV V D+ D P F PS ++
Sbjct: 94 STIDRESLPSDVINLVVLSS--------APTYPTE--VRVLVRDLNDNAPVFPDPSIVVT 143
Query: 403 VQEDAQVGSLVGVVTARDPDAANRPV---RYAIDRESDLDQI-FDIDADTGA------IV 452
+ED+ G V + TA D D + V Y I R ++ + DI + +V
Sbjct: 144 FKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLV 203
Query: 453 TGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATP-YEAAVCEDA 511
+ GLDRE + + V + + + + + D+NDNPP + Y+A V EDA
Sbjct: 204 SKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDA 263
Query: 512 KPGQLIQTISVVDRDEPQGGHRFYFRLVPEA---PSNPHFSLLDIQDNTAAVHTQHVGFN 568
G + ++ D DE +RL E +P L+ ++ + + F
Sbjct: 264 VVGSSVLQVAAADADEGTNAD-IRYRLQDEGTPFQMDPETGLITVR--------EPLDFE 314
Query: 569 RQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGC-DSSGTIQSCNTTAFVMAASLSPGAL 627
+ Q + L + +D G P+L+ I++ D+ ++ A AS+ A
Sbjct: 315 ARRQ--YSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQ 372
Query: 628 IALLVCVL 635
+ +V +L
Sbjct: 373 VGTVVALL 380
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 206 bits (523), Expect = 9e-53
Identities = 163/523 (31%), Positives = 245/523 (46%), Gaps = 40/523 (7%)
Query: 88 SDSDEG-DGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARD----- 141
+D D G +G + Y +SG + F+ID TG + + LDRE YTL D
Sbjct: 742 TDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQ 801
Query: 142 RATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYG 201
+A RLL + V D ND+ P FL Y V+E + ++QV A+D D G
Sbjct: 802 KAAWRLLH------VVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKD---LG 852
Query: 202 SSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGST 261
+ + YS++ F++D TGV+ A P LDRE Q + + I+A D A + L +
Sbjct: 853 PNGHVTYSIVTDTDTFSIDSVTGVVNIARP-LDRELQHEHSLKIEARDQAREEPQLFSTV 911
Query: 262 TVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESS 321
V + + DVNDNPP F Y+ ++E P GT + ++A D D+G++ + Y L D
Sbjct: 912 VVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGE 971
Query: 322 SGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIV 381
DV K++ A+ +VQ +LDFE + V+ + + A +K + V
Sbjct: 972 GNFDVDKLS------GAVRIVQ-QLDFEKKQVYNLTVRAKDK------GKPVSLSSTCYV 1018
Query: 382 RVAVTDVDE---PPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRESD 437
V V DV+E PP F V+EDA VGSLV V+A D DA + +RY+I R+
Sbjct: 1019 EVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSI-RDGS 1077
Query: 438 LDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPP 497
+F I +TG I T LDRE+ + +TV A + S + I + DVNDN P
Sbjct: 1078 GVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAP 1137
Query: 498 ELATP-YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDN 556
+ + P Y + E++ + I D D Y NP I
Sbjct: 1138 QTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY----KITSGNPQ-GFFSIHPK 1192
Query: 557 TAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRI 599
T + T +R++QD L + V D+G P S+ + ++I
Sbjct: 1193 TGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKI 1235
Score = 196 bits (497), Expect = 1e-49
Identities = 156/519 (30%), Positives = 254/519 (48%), Gaps = 38/519 (7%)
Query: 88 SDSD-EGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNR 146
+D+D + I YT+ G GA F ++ TG++ LDRE++ Y L +A D
Sbjct: 3048 TDADIRSNAEITYTLLGSGAEK-FKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRF 3106
Query: 147 LLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARL 206
++ ++ ++D+ND+ P F PY +V E + GT + +V A+DAD G + ++
Sbjct: 3107 C---QASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADA---GLNRKI 3160
Query: 207 VYSVLDG-EHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTI 265
+YS++D + F+++ +G+I+ P LDRE Q Y + ++A D G L+ + TV +
Sbjct: 3161 LYSLIDSADGQFSINELSGIIQLEKP-LDRELQAVYTLSLKAVDQ-GLPRRLTATGTVIV 3218
Query: 266 VVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGD 325
V D+NDNPP F + Y ++ E +GT V +V A D+ N ++TY + SG +
Sbjct: 3219 SVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSI----ISGNE 3274
Query: 326 VFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGT--FRDQAIVRV 383
K + DS T I+ + LD+ES + + +EA D GT D A V V
Sbjct: 3275 HGKFSIDSKTGAVFII--ENLDYESSHEYYLTVEA---------TDGGTPSLSDVATVNV 3323
Query: 384 AVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRESDLDQI 441
VTD+ D P F + + EDA + V V A D D +N + Y+I + +
Sbjct: 3324 NVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSII-DGNQGSS 3382
Query: 442 FDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELAT 501
F ID G + K LDRET + +TV A + + +++ ++ I + DVNDN P +
Sbjct: 3383 FTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSR 3442
Query: 502 PYEAAVCEDAKP-GQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAV 560
+ + ++ KP G + + V D D G F+F +V + N V
Sbjct: 3443 GNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKA------FEVNPQGV 3496
Query: 561 HTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRI 599
R+E+D + L + V D+G P LSS + IR+
Sbjct: 3497 LLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRV 3535
Score = 163 bits (413), Expect = 5e-40
Identities = 145/484 (29%), Positives = 219/484 (45%), Gaps = 64/484 (13%)
Query: 72 VEEYTGTEPLYVGKI------HSDSDEGDGAIKYTI-SGEGAGTIFLIDELTGDIHAMER 124
VE+ T E VG + H + DG I+Y+I G G G +F I E TG I +R
Sbjct: 1038 VEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG-VFKIGEETGVIETSDR 1096
Query: 125 LDREQKTFYTLRAQARDRATNRLLEPESEFI---IKVQDINDSEPRFLHGPYIGSVAELS 181
LDRE + Y L A D+ + P S FI I+V+D+ND+ P+ Y + E S
Sbjct: 1097 LDRESTSHYWLTVFATDQG----VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENS 1152
Query: 182 PTGTSVMQVMASDADDPTYGSSARLVYSVLDG--EHHFTVDPKTGVIRTAVPDLDRESQE 239
P SV+Q+ +A DP S+ +L+Y + G + F++ PKTG+I T LDRE Q+
Sbjct: 1153 PKDVSVVQI---EAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQD 1209
Query: 240 RYEVVIQATDMAGQLGGLSGSTTVTIVV--TDVNDNPPRFPQKMYQFSIQE-SAPIGTAV 296
+ + + TD G ST ++V D NDN P+F QK Y+ + E P
Sbjct: 1210 EHILEVTVTDN----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERN 1265
Query: 297 GR------VKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFES 350
R V A D D G N +++Y ++D + G + T +V KR
Sbjct: 1266 ARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG-------VVSSKRFSAAG 1318
Query: 351 QPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLE------VQ 404
+ + + D G + + R+ + + +P P E V
Sbjct: 1319 E----------YDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVM 1368
Query: 405 EDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGW 464
E V ++GV++ P P+ + I + D FD+D TG I+ K LD E
Sbjct: 1369 ESDPVAHMIGVISVEPPGI---PLWFDI-TGGNYDSHFDVDKGTGTIIVAKPLDAEQKSN 1424
Query: 465 HNITVLAMEADNHAQLSRASLRIRILDVNDNPPELAT-PYEAAVCEDAKPGQLIQTISVV 523
+N+TV EA + + I+++D ND+ P+ +T YE + ED P I IS V
Sbjct: 1425 YNLTV---EATDGTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAV 1481
Query: 524 DRDE 527
D+DE
Sbjct: 1482 DQDE 1485
Score = 157 bits (397), Expect = 4e-38
Identities = 148/559 (26%), Positives = 243/559 (43%), Gaps = 39/559 (6%)
Query: 70 FVVEEYTGTEPLYVGKIHSDSDEG-DGAIKYTISGEGAGTI---FLIDELTGDIHAMERL 125
F+VE G + + SD+D G +G + Y++ + + F I+ TG I ++ L
Sbjct: 2817 FIVENLPGGSRVIQIRA-SDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKEL 2875
Query: 126 DREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGT 185
D E++ Y ++ A D L + + V D+NDS PRF Y G+V+E P G
Sbjct: 2876 DHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGG 2935
Query: 186 SVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAV-PDLDRESQERYEVV 244
+ + +DAD + D F V+ + V LDRE ++ Y +
Sbjct: 2936 VIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLT 2995
Query: 245 IQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDS 304
I ATD G S V + V D NDN P + +Y +I E G + ++ A D+
Sbjct: 2996 ITATD-----GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDA 3050
Query: 305 DVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKF 364
D+ N ++TY L SG + FK+ D+ + LD E Q V+ +++ A
Sbjct: 3051 DIRSNAEITYTL---LGSGAEKFKLNPDTGE----LKTSTPLDREEQAVYHLLVRA---- 3099
Query: 365 VDPRFADLGTFRDQAIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDA 423
D G QA + + + DV D PEF + V E+ + G+L+ V A D DA
Sbjct: 3100 -----TDGGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADA 3154
Query: 424 A-NRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQL-S 481
NR + Y++ +D F I+ +G I K LDRE + +++ A++ +L +
Sbjct: 3155 GLNRKILYSLIDSADGQ--FSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTA 3212
Query: 482 RASLRIRILDVNDNPPELA-TPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVP 540
++ + +LD+NDNPP Y A V ED G + + RD Y +
Sbjct: 3213 TGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSII-- 3270
Query: 541 EAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRIC 600
S I T AV + + ++L + D G P+LS T+ + +
Sbjct: 3271 ---SGNEHGKFSIDSKTGAVFIIE-NLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVT 3326
Query: 601 GCDSSGTIQSCNTTAFVMA 619
+ + + S +T V++
Sbjct: 3327 DINDNTPVFSQDTYTTVIS 3345
Score = 153 bits (386), Expect = 7e-37
Identities = 140/506 (27%), Positives = 229/506 (45%), Gaps = 54/506 (10%)
Query: 99 YTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKV 158
+ I+G + F +D+ TG I + LD EQK+ Y L +A D T L ++ IKV
Sbjct: 1391 FDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL----TQVFIKV 1446
Query: 159 QDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEH--- 215
D ND P+F Y + E + T ++Q+ A D D+ +L+Y++
Sbjct: 1447 IDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKN-----KLIYTLQSSRDPLS 1501
Query: 216 --HFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDN 273
F +DP TG + T+ LD E+ ++ + + D + + + V+D ND+
Sbjct: 1502 LKKFRLDPATGSLYTS-EKLDHEAVHQHTLTVMVRDQ--DVPVKRNFARIVVNVSDTNDH 1558
Query: 274 PPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDS 333
P F Y+ + ESA +G+ V +V A D D G+N ++ Y + ES + G+ F +
Sbjct: 1559 APWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSI--ESGNIGNSFMI---- 1612
Query: 334 DTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDE-PP 392
D I K LD +Q + ++++A +K P + VR+ VT D P
Sbjct: 1613 DPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPP-------MSEITSVRIFVTIADNASP 1665
Query: 393 EFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIV 452
+F +E+ E +GS VG+VTA + V Y I ++ + FDI+ +G I+
Sbjct: 1666 KFTSKEYSVELSETVSIGSFVGMVTAHSQSS----VVYEI-KDGNTGDAFDINPHSGTII 1720
Query: 453 TGKGLDRETAGWHNITVLAMEADNHAQLS-RASLRIRILDVNDNPPE-LATPYEAAVCED 510
T K LD ET I L ++ N A LS ++ + + D NDN P + Y + E
Sbjct: 1721 TQKALDFETL---PIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISES 1777
Query: 511 AKPGQLIQT-------ISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQ 563
A ++ T I D D+ Y + P + +F+ I +T A+HT
Sbjct: 1778 ASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSV--HTYFA---IDSSTGAIHTV 1832
Query: 564 HVGFNRQEQDVFFLPILVVDSGPPTL 589
+ + +E +F + V D G P L
Sbjct: 1833 -LSLDYEETSIFHFTVQVHDMGTPRL 1857
Score = 152 bits (385), Expect = 9e-37
Identities = 144/555 (25%), Positives = 243/555 (43%), Gaps = 42/555 (7%)
Query: 89 DSDEGD-GAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRL 147
D+D D ++Y+I F+ID TG I K FY+L D +
Sbjct: 2416 DADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDG----V 2471
Query: 148 LEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLV 207
++ + V N P FL Y +AE +P T VM+V +D D YG +
Sbjct: 2472 FRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYG---HVT 2528
Query: 208 YSVLD--GEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTI 265
Y +++ + F ++ + + + LDRE+ E VI MA GG TV +
Sbjct: 2529 YHIVNDFAKDRFYINERGQIF--TLEKLDRETPA--EKVISVRLMAKDAGGKVAFCTVNV 2584
Query: 266 VVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSS--- 322
++TD NDN P+F Y+ +I SA GT+V +V A D+D G N D+TY ++ +S S
Sbjct: 2585 ILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKE 2644
Query: 323 GGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVR 382
++ K++ T+E++I ++ E FV R D G+ +++V
Sbjct: 2645 NLEINKLSGVITTKESLIGLEN--------------EFFTFFV--RAVDNGSPSKESVVL 2688
Query: 383 VAVTDVD---EPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLD 439
V V + + P+F P V ED +G+ + ++ A + ES+ D
Sbjct: 2689 VYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRD 2748
Query: 440 QIFDIDADTGAIVTGKGLDRETAGWHNITVLA-MEADNHAQLSRASLRIRILDVNDNPPE 498
+ F ID +G + K LD ET W+ ++LA D+H ++ + I++ D NDN P
Sbjct: 2749 ESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPV 2808
Query: 499 L-ATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNT 557
++PYEA + E+ G + I D D G Y + ++ S I T
Sbjct: 2809 FESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMY--SLDQSQSVEVIESFAINMET 2866
Query: 558 AAVHTQHVGFNRQEQDVFFLPILVVDSGPP-TLSSTGTLTIRICGCDSSGTIQSCNTTAF 616
+ T + +++D + + ++ D G LSST + + + + S +
Sbjct: 2867 GWITTLK-ELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKG 2925
Query: 617 VMAASLSPGALIALL 631
++ G +IA+L
Sbjct: 2926 TVSEDDPQGGVIAIL 2940
Score = 150 bits (379), Expect = 5e-36
Identities = 135/467 (28%), Positives = 222/467 (47%), Gaps = 33/467 (7%)
Query: 70 FVVEEYTGTEP--LYVGKIHSDSDEG-DGAIKYTISGEGAGTIFLIDELTGDIHAMERLD 126
+ + + TEP L +D+D G + I Y++ G F I+EL+G I + LD
Sbjct: 3130 YAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQ-FSINELSGIIQLEKPLD 3188
Query: 127 REQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTS 186
RE + YTL +A D+ R L I+ V DIND+ P F + Y +V+E GT
Sbjct: 3189 RELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTE 3248
Query: 187 VMQVMASDADDPTYGSSARLVYSVLDGEHH--FTVDPKTGVIRTAVPDLDRESQERYEVV 244
V+QV A+ D ++A + YS++ G H F++D KTG + + +LD ES Y +
Sbjct: 3249 VLQVYAASRD---IEANAEITYSIISGNEHGKFSIDSKTGAV-FIIENLDYESSHEYYLT 3304
Query: 245 IQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDS 304
++ATD G LS TV + VTD+NDN P F Q Y I E A + +V V A+D+
Sbjct: 3305 VEATD--GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDA 3362
Query: 305 DVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKF 364
D N+ + Y + D + G F + D + V K LD E+ +T+ ++A +
Sbjct: 3363 DGPSNSHIHYSIID--GNQGSSFTI----DPVRGEVKVTKLLDRETISGYTLTVQASDNG 3416
Query: 365 VDPRFADLGTFRDQAIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDA 423
PR + V + V+DV D P F + + +QE+ VG V + D D+
Sbjct: 3417 SPPRV-------NTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDS 3469
Query: 424 ANR--PVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLS 481
++ P + I +D ++ F+++ G ++T + R+ + + V + S
Sbjct: 3470 SHNGPPFFFTIVTGND-EKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSS 3527
Query: 482 RASLRIRILDVNDNPPELATPYEAAVCEDAK--PGQLIQTISVVDRD 526
+ IR+++ + PP + P E + + G +I I D+D
Sbjct: 3528 LTYIDIRVIEESIYPPAI-LPLEIFITSSGEEYSGGVIGKIHATDQD 3573
Score = 134 bits (337), Expect = 3e-31
Identities = 114/392 (29%), Positives = 185/392 (47%), Gaps = 36/392 (9%)
Query: 152 SEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVL 211
+E I+ + +N + P F Y +AE + V+ V A+ + ++ YS+
Sbjct: 2166 AEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE------GLKVFYSIT 2219
Query: 212 DGE--HHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTD 269
DG+ FT++ TGVI P LD E+ Y++ I+ATD L G V I+V D
Sbjct: 2220 DGDPFSQFTINFNTGVINVIAP-LDFEAHPAYKLSIRATD---SLTGAHAEVFVDIIVDD 2275
Query: 270 VNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKV 329
+NDNPP F Q+ Y ++ E++ IGT+V +V+A DSD N ++Y + S D F V
Sbjct: 2276 INDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHV 2335
Query: 330 TTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDV- 388
D+ +I + + LD+E HT+ + A++ + T IV V VTD+
Sbjct: 2336 ----DSSTGLISLLRTLDYEQSRQHTIFVRAVD-------GGMPTLSSDVIVTVDVTDLN 2384
Query: 389 DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAAN-RPVRYAIDRESDLDQIFDIDAD 447
D PP F + E A G V V A D D+++ ++Y+I +D + F ID+
Sbjct: 2385 DNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGND-HKHFVIDSA 2443
Query: 448 TGAIVTGKGLDRET-AGWHNITVLAMEADNHAQLSRASLRIRILDVNDN---PPELATPY 503
TG I+T L R ++++ + + + R+S ++ + + N P L Y
Sbjct: 2444 TG-IITLSNLHRHALKPFYSLNLSVSDG-----VFRSSTQVHVTVIGGNLHSPAFLQNEY 2497
Query: 504 EAAVCEDAKPGQLIQTISVVDRDEPQGGHRFY 535
E + E+A L+ + D D GH Y
Sbjct: 2498 EVELAENAPLHTLVMEVKTTDGDSGIYGHVTY 2529
Score = 127 bits (318), Expect = 6e-29
Identities = 132/530 (24%), Positives = 228/530 (43%), Gaps = 52/530 (9%)
Query: 82 YVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARD 141
+VG + + S ++ Y I G F I+ +G I + LD E YTL Q +
Sbjct: 1685 FVGMVTAHSQS---SVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTN 1741
Query: 142 RATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQ-------VMASD 194
A L + ++ +QD ND+ P F+ Y G ++E + + V+ + A+D
Sbjct: 1742 MAG---LSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAAD 1798
Query: 195 ADDPTYGSSARLVYSVLDGEHH--FTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAG 252
AD S+A LVY +++ H F +D TG I T + LD E + +Q DM
Sbjct: 1799 ADKD---SNALLVYHIVEPSVHTYFAIDSSTGAIHTVL-SLDYEETSIFHFTVQVHDMGT 1854
Query: 253 QLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDM 312
+ VT+ V D+ND PP F + +Y+ S+ G V V A D+D + +
Sbjct: 1855 PRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQL 1914
Query: 313 TYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADL 372
Y + + + G+ F + D + + VQ S+ TV + D RFA L
Sbjct: 1915 IYSITE--GNIGEKFSM----DYKTGALTVQNTTQLRSRYELTV------RASDGRFAGL 1962
Query: 373 GTFRDQAIVRVAVTDVDEPP-EFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYA 431
+ V++ V + E +F V+E++ + V+TA + N P+ Y
Sbjct: 1963 TS------VKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIG-NPINEPLFYH 2015
Query: 432 IDRESDLDQIFDIDADTGAI-VTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRIL 490
I + D+ F I +G + TG DRE ++ V E + ++ +++ +
Sbjct: 2016 I---LNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVE 2072
Query: 491 DVNDNPPELAT-PYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFS 549
D NDN P PY A V D + G +I+ ++ VDRD + G Y+ + HF
Sbjct: 2073 DQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYL----KEHHEHFQ 2128
Query: 550 LLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRI 599
+ + + + + N++ + + ++ D G P S+ + I +
Sbjct: 2129 IGPLGEISLKKQFELDTLNKE----YLVTVVAKDGGNPAFSAEVIVPITV 2174
Score = 116 bits (290), Expect = 1e-25
Identities = 132/513 (25%), Positives = 218/513 (42%), Gaps = 53/513 (10%)
Query: 89 DSDEGDGA-IKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRL 147
D D+G A + Y+I G F+ID + G I + LDR + Y L +A D+ + +
Sbjct: 1588 DKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPM 1647
Query: 148 LEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLV 207
E S I V +++ P+F Y ++E G+ V V A S + +V
Sbjct: 1648 SEITSVRIF-VTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAH--------SQSSVV 1698
Query: 208 YSVLDGE--HHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTI 265
Y + DG F ++P +G I T LD E+ Y ++IQ T+MA GLS +TTV +
Sbjct: 1699 YEIKDGNTGDAFDINPHSGTIITQ-KALDFETLPIYTLIIQGTNMA----GLSTNTTVLV 1753
Query: 266 VVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGR-------VKAEDSDVGENTDMTYHLKD 318
+ D NDN P F Q Y I ESA I + V ++A D+D N + YH+ +
Sbjct: 1754 HLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVE 1813
Query: 319 ESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQ 378
S F + D+ I LD+E + ++ + FA+
Sbjct: 1814 PSVH--TYFAI----DSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYA----- 1862
Query: 379 AIVRVAVTDVDE-PPEFRPPSGLLEVQEDAQVGSLVGVVTARDPD-AANRPVRYAIDRES 436
A V V V D+++ PP F P + G V V A D D +A + Y+I E
Sbjct: 1863 ANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSI-TEG 1921
Query: 437 DLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNP 496
++ + F +D TGA+ + T + L + A + S++I + + ++
Sbjct: 1922 NIGEKFSMDYKTGALTV-----QNTTQLRSRYELTVRASDGRFAGLTSVKINVKESKESH 1976
Query: 497 PELATP-YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQD 555
+ Y A V E++ + + I+ + P FY L P+ I
Sbjct: 1977 LKFTQDVYSAVVKENSTEAETLAVITAI--GNPINEPLFYHILNPD-------RRFKISR 2027
Query: 556 NTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPT 588
+ + T F+R++Q+ F + + V + P+
Sbjct: 2028 TSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPS 2060
Score = 111 bits (278), Expect = 2e-24
Identities = 164/646 (25%), Positives = 265/646 (41%), Gaps = 117/646 (18%)
Query: 89 DSDEGD-GAIKYTISGEGAGTIFLIDELTGDIHAMERLDRE-QKTFYTLRAQARDRATNR 146
D DEG+ G + Y+I+ F ID TG + E LD E YTLR +A D
Sbjct: 489 DPDEGENGYVTYSIANLNH-VPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPY 547
Query: 147 LLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARL 206
E E I + ++ND+ P F G++ G + V A DAD+ +L
Sbjct: 548 RREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE------LQL 601
Query: 207 V-YSVLDGEH--HFTVDPKTGVI--RTAVPDLDRESQERYEVVIQATDMAG--------- 252
V Y + G F+++P +GV+ + ++ D + + I ATD
Sbjct: 602 VQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINI 661
Query: 253 ---------------------------QLGGLSGSTTVTIVVTD---VNDNPPRFPQKMY 282
Q L V + D VN + P+F +
Sbjct: 662 TVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLP 721
Query: 283 Q-FSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGD---VFKVTTDSDTQEA 338
++E+ P+G++V + + D D G N + Y + SGG+ F + D +
Sbjct: 722 TGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVY-----AVSGGNEDSCFMI----DMETG 772
Query: 339 IIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQA--IVRVAVTDV-DEPPEFR 395
++ + LD E+ +T+ + DLG + A ++ V V D D PPEF
Sbjct: 773 MLKILSPLDRETTDKYTLNITVY---------DLGIPQKAAWRLLHVVVVDANDNPPEFL 823
Query: 396 PPSGLLEVQEDAQVGSLVGVVTARDPD-AANRPVRYAIDRESDLDQIFDIDADTGAIVTG 454
S +EV ED +V S + V A D D N V Y+I ++D F ID+ TG +
Sbjct: 824 QESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD---TFSIDSVTGVVNIA 880
Query: 455 KGLDRETAGWHNITVLAM-EADNHAQL-SRASLRIRILDVNDNPPELATP-YEAAVCEDA 511
+ LDRE H++ + A +A QL S +++ + DVNDNPP P Y V ED
Sbjct: 881 RPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDL 940
Query: 512 KPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVH-TQHVGFNRQ 570
G +I + D D Q G + + L+ N D+ + AV Q + F ++
Sbjct: 941 PEGTVIMWLEAHDPDLGQSG-QVRYSLLDHGEGN-----FDVDKLSGAVRIVQQLDFEKK 994
Query: 571 EQDVFFLPILVVDSGPP-TLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIA 629
+ V+ L + D G P +LSST + + + D + + ++FV ++ A +
Sbjct: 995 Q--VYNLTVRAKDKGKPVSLSSTCYVEVEV--VDVNENLHPPVFSSFVEKGTVKEDAPVG 1050
Query: 630 LLVCVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGG 675
LV +S+ +++ RD I+Y+ G
Sbjct: 1051 SLVMT--------------------VSAHDEDARRDGEIRYSIRDG 1076
Score = 107 bits (268), Expect = 3e-23
Identities = 126/530 (23%), Positives = 217/530 (40%), Gaps = 47/530 (8%)
Query: 75 YTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYT 134
Y G + + V +DS I Y+I+ G F +D TG + + Y
Sbjct: 1893 YKGVKVITVNATDADSSAFSQLI-YSITEGNIGEKFSMDYKTGALTVQNTTQLRSR--YE 1949
Query: 135 LRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTS--VMQVMA 192
L +A D L + I V++ +S +F Y V E S + V+ +
Sbjct: 1950 LTVRASDGRFAGLTSVK----INVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIG 2005
Query: 193 SDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAG 252
+ ++P L Y +L+ + F + +GV+ T DRE QE ++VV++ T+
Sbjct: 2006 NPINEP-------LFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEE-- 2056
Query: 253 QLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDM 312
V ++V D NDN P F Y ++ +G + V A D D G N ++
Sbjct: 2057 HKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEV 2116
Query: 313 TYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADL 372
Y+LK+ + F++ + I ++K+ + ++ ++ +P F+
Sbjct: 2117 HYYLKEHH----EHFQIGPLGE-----ISLKKQFELDTLNKEYLVTVVAKDGGNPAFS-- 2165
Query: 373 GTFRDQAIVRVAVTDVDEP-PEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYA 431
A V V +T +++ P F P E+ E QV S V V A P+ V Y+
Sbjct: 2166 ------AEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLK--VFYS 2217
Query: 432 IDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILD 491
I Q F I+ +TG I LD E + +++ A ++ A + + I + D
Sbjct: 2218 ITDGDPFSQ-FTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAH-AEVFVDIIVDD 2275
Query: 492 VNDNPPELA-TPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSL 550
+NDNPP A Y + E + G + + D D Y + S+ HF
Sbjct: 2276 INDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHF-- 2333
Query: 551 LDIQDNTAAVH-TQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRI 599
+ +T + + + + + Q F + VD G PTLSS +T+ +
Sbjct: 2334 -HVDSSTGLISLLRTLDYEQSRQHTIF--VRAVDGGMPTLSSDVIVTVDV 2380
Score = 102 bits (254), Expect = 1e-21
Identities = 117/479 (24%), Positives = 203/479 (42%), Gaps = 57/479 (11%)
Query: 97 IKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFII 156
++Y F ++ TG I +E + R+Q + L DR + ++ ++
Sbjct: 398 LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR------KASTKVLV 451
Query: 157 KVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEH- 215
KV N + P F Y + E P GT+VM + A D D+ G + + YS+ + H
Sbjct: 452 KVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDE---GENGYVTYSIANLNHV 508
Query: 216 HFTVDPKTGVIRTAVPDLDRESQER-YEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNP 274
F +D TG + T+ +LD E R Y + I+A+D G TI + ++NDN
Sbjct: 509 PFAIDHFTGAVSTS-ENLDYELMPRVYTLRIRASDW-GLPYRREVEVLATITLNNLNDNT 566
Query: 275 PRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSD 334
P F + + +I +G + V A D+D E + Y + E+ + D F + +S
Sbjct: 567 PLFEKINCEGTIPRDLGVGEQITTVSAIDAD--ELQLVQYQI--EAGNELDFFSLNPNSG 622
Query: 335 T----QEAIIVVQKRLDFES------------QPVH-TVILEALNKFVDPRFADLGTFRD 377
+ + + ++ F S P++ + + A +K V+ + + G +
Sbjct: 623 VLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKM 682
Query: 378 QAIVRVAVTDVDEP-----------------PEFRP--PSGLLEVQEDAQVGSLVGVVTA 418
A + + P+FR P+G ++V+E+ VGS V + +
Sbjct: 683 LAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTG-IQVKENQPVGSSVIFMNS 741
Query: 419 RDPDAA-NRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNH 477
D D N + YA+ ++ D F ID +TG + LDRET + + + +
Sbjct: 742 TDLDTGFNGKLVYAVSGGNE-DSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIP 800
Query: 478 AQLSRASLRIRILDVNDNPPE-LATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFY 535
+ + L + ++D NDNPPE L Y V ED + I + D+D GH Y
Sbjct: 801 QKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTY 859
Score = 99.0 bits (245), Expect = 2e-20
Identities = 110/421 (26%), Positives = 187/421 (44%), Gaps = 38/421 (9%)
Query: 125 LDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTG 184
L+RE K YTL +A ++ TN +E ++ ++V D ND P F Y S+ E +
Sbjct: 108 LNREVKDHYTLIVKALEKNTN--VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
Query: 185 TSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVV 244
TS+ +V A+DAD G++ YS D F + P +GVI LD + YE+
Sbjct: 166 TSIARVSATDAD---IGTNGEFYYSFKDRTDMFAIHPTSGVI-VLTGRLDYLETKLYEME 221
Query: 245 IQATDMAGQLGGLSGSTT---VTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKA 301
I A D +L G SG ++ +T+ + N+ P S + P A V
Sbjct: 222 ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDP---AYAIVTV 278
Query: 302 EDSDVGENTDMTYHLKDESSSGGDVFK----VTTDSDTQEAIIVVQKRLDFESQPV-HTV 356
+D D G N D + S GD+ + V + ++E + +D++S P + +
Sbjct: 279 DDCDQGANGD----IASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNL 334
Query: 357 ILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDE-PPEFRPPSGLLEVQEDAQVGSLVGV 415
L+A +K P+F+ + ++ V P +F E+ E A + V +
Sbjct: 335 TLQAKDKGTPPQFSSV------KVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVM 388
Query: 416 VTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEAD 475
V A A +RY + + + F ++ +TG I + + R+ A + V +
Sbjct: 389 VKA---IPAYSHLRY-VFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSD-- 442
Query: 476 NHAQLSRASLRIRILDVNDNPPELA-TPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRF 534
+ + + +++L N NPPE T Y+AA E+ G + ++S VD DE + G+
Sbjct: 443 ---RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVT 499
Query: 535 Y 535
Y
Sbjct: 500 Y 500
Score = 92.4 bits (228), Expect = 2e-18
Identities = 99/376 (26%), Positives = 165/376 (43%), Gaps = 54/376 (14%)
Query: 119 IHAMERLDREQKTF-YTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGP----- 172
+ A+ +D + F Y L QA+D+ T P +KV I+ + P+F GP
Sbjct: 317 VKAIGGIDWDSHPFGYNLTLQAKDKGT-----PPQFSSVKV--IHVTSPQFKAGPVKFEK 369
Query: 173 --YIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAV 230
Y ++E +P T V+ V A P Y S R V+ G+ F+++ TG+I
Sbjct: 370 DVYRAEISEFAPPNTPVVMVKAI----PAY-SHLRYVFKSTPGKAKFSLNYNTGLISILE 424
Query: 231 PDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESA 290
P + R+ +E+ + +D ST V + V N NPP F Q Y+ + E+
Sbjct: 425 P-VKRQQAAHFELEVTTSDR-------KASTKVLVKVLGANSNPPEFTQTAYKAAFDENV 476
Query: 291 PIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFES 350
PIGT V + A D D GEN +TY + ++ V D + + LD+E
Sbjct: 477 PIGTTVMSLSAVDPDEGENGYVTYSI-------ANLNHVPFAIDHFTGAVSTSENLDYEL 529
Query: 351 QP-VHTVILEALNKFVDPRFADLG-TFRDQAIVRVAVT---DVDEPPEFRPPSGLLEVQE 405
P V+T+ + A +D G +R + V +T D P F + +
Sbjct: 530 MPRVYTLRIRA---------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPR 580
Query: 406 DAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLD---RETA 462
D VG + V+A D D + V+Y I+ ++LD F ++ ++G + + L
Sbjct: 581 DLGVGEQITTVSAIDADEL-QLVQYQIEAGNELD-FFSLNPNSGVLSLKRSLMDGLGAKV 638
Query: 463 GWHNITVLAMEADNHA 478
+H++ + A + +N A
Sbjct: 639 SFHSLRITATDGENFA 654
Score = 60.5 bits (145), Expect = 6e-09
Identities = 85/400 (21%), Positives = 157/400 (39%), Gaps = 81/400 (20%)
Query: 233 LDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPI 292
L+RE ++ Y ++++A + + + T V + V D ND P F Y S+ E+ I
Sbjct: 108 LNREVKDHYTLIVKALE---KNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAI 164
Query: 293 GTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQP 352
T++ RV A D+D+G N + Y KD + D+F + S +IV+ RLD+
Sbjct: 165 RTSIARVSATDADIGTNGEFYYSFKDRT----DMFAIHPTS----GVIVLTGRLDYLETK 216
Query: 353 VHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSL 412
++ + + A ++ + + I +A V +++ + +
Sbjct: 217 LYEMEILAADR-------GMKLYGSSGISSMAKLTV-------------HIEQANECAPV 256
Query: 413 VGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGK----------------- 455
+ VT P +R YAI D DQ + D + +IV G
Sbjct: 257 ITAVTL-SPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEY 315
Query: 456 ------GLDRETAGW-HNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATP------ 502
G+D ++ + +N+T+ A + Q S ++++ V +P A P
Sbjct: 316 KVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFS----SVKVIHVT-SPQFKAGPVKFEKD 370
Query: 503 -YEAAVCEDAKPGQLIQTISVVDRDEPQGGH-RFYFRLVP---EAPSNPHFSLLDIQDNT 557
Y A + E A P + + + P H R+ F+ P + N + L+ I +
Sbjct: 371 VYRAEISEFAPPNTPVVMVKAI----PAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPV 426
Query: 558 AAVHTQHVGF-----NRQEQDVFFLPILVVDSGPPTLSST 592
H +R+ + +L +S PP + T
Sbjct: 427 KRQQAAHFELEVTTSDRKASTKVLVKVLGANSNPPEFTQT 466
>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
sapiens]
Length = 847
Score = 204 bits (518), Expect = 4e-52
Identities = 192/676 (28%), Positives = 304/676 (44%), Gaps = 44/676 (6%)
Query: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAG----TIFLIDE 114
R KR W ++E G PL++ ++ SD+ + + I Y+I G G +F ++
Sbjct: 132 RAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQ-NYTIYYSIRGPGVDQEPRNLFYVER 190
Query: 115 LTGDIHAMERLDREQKTFYTLRAQAR--DRATNRLLEPESEFIIKVQDINDSEPRFLHGP 172
TG+++ +DREQ + + A A D T L P IIK++D ND+ P F
Sbjct: 191 DTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLP---LIIKIEDENDNYPIFTEET 247
Query: 173 YIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLD----GEHHFTVDPKTGVIRT 228
Y ++ E GT+V QV A+D D+P RL YS++ F++ P TGVI T
Sbjct: 248 YTFTIFENCRVGTTVGQVCATDKDEPDT-MHTRLKYSIIGQVPPSPTLFSMHPTTGVITT 306
Query: 229 AVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQE 288
LDRE ++Y++ I+ DM GQ GL ++T I + DVND+ P F + Y S++E
Sbjct: 307 TSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEE 366
Query: 289 SAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDF 348
+ + + RV ED D+ + + + FK+ TD+ T E ++ V K L++
Sbjct: 367 NT-VDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNY 425
Query: 349 ESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQ 408
E + + + +N+ R A + A V V V D DE PE PP + ++E+A+
Sbjct: 426 EEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAE 485
Query: 409 VGSLVGVVTARDPDA-ANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETA----G 463
VG+ A DP+ ++ +RY + +D ID +TG+I + LDRE G
Sbjct: 486 VGTTSNGYKAYDPETRSSSGIRY--KKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNG 543
Query: 464 WHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVV 523
+NITVLA +D + +L I + DVNDN P + P + + KP I V
Sbjct: 544 IYNITVLA--SDQGGRTCTGTLGIILQDVNDNSPFI--PKKTVII--CKPTMSSAEIVAV 597
Query: 524 DRDEPQGGHRFYFRLVPEAPS-NPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVV 582
D DEP G F F L + L I D A + Q N + +PI V
Sbjct: 598 DPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQ----NDPPFGSYVVPITVR 653
Query: 583 DSGPPTLSSTGTLTIRICGC-DSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLV 641
D +SS +L + +C C + + L A++A+L+ + +L ++
Sbjct: 654 DR--LGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCIL 711
Query: 642 LLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGD 701
++ D+ + N+I N E G D + Y + + + G
Sbjct: 712 FTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPG--DDKVYSANGFTT-----QTVGAS 764
Query: 702 GGGSAGGGAGGGSGGG 717
G G G GG
Sbjct: 765 AQGVCGTVGSGIKNGG 780
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 190 bits (482), Expect = 5e-48
Identities = 153/522 (29%), Positives = 245/522 (46%), Gaps = 40/522 (7%)
Query: 89 DSDEG-DGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARD-----R 142
D+D G +G + +TIS + F ID TG + + +DRE Y L D +
Sbjct: 752 DADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQK 811
Query: 143 ATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGS 202
++ RLL I V+D ND+ P F+ Y ++ E S GT ++QV A D D GS
Sbjct: 812 SSWRLLT------INVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD---LGS 862
Query: 203 SARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTT 262
+ + YSVL F ++ TG++ A LDRES+ Y + I+A D A L T
Sbjct: 863 NGEVTYSVLTDTQQFAINSSTGIVYVA-DQLDRESKANYSLKIEARDKAESGQQLFSVVT 921
Query: 263 VTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSS 322
+ + + DVND P F Y + E P+GT + ++ D D+G + Y L ++ +
Sbjct: 922 LKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNG 981
Query: 323 GGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVR 382
++ D I + K LD+E Q + + + A +K + + + V
Sbjct: 982 RFEI-------DKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSV------SFVE 1028
Query: 383 VAVTDVDE---PPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAA-NRPVRYAIDRESDL 438
V V DV+E P F + + V+E++++G+ V VTARD D+ + ++Y+I S L
Sbjct: 1029 VEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGL 1088
Query: 439 DQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPE 498
+ F ID ++G I LDRET G + +TV A + S + I + DVNDN P
Sbjct: 1089 GR-FSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPL 1147
Query: 499 LATP-YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNT 557
+ P Y V E++ + I D D + +R+ P N F ++I+ T
Sbjct: 1148 TSEPIYYPVVMENSPKDVSVIQIQAEDPDS-SSNEKLTYRITSGNPQN--FFAINIK--T 1202
Query: 558 AAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRI 599
+ T +R++Q FL + V D GP ST + +++
Sbjct: 1203 GLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQV 1244
Score = 172 bits (436), Expect = 1e-42
Identities = 155/556 (27%), Positives = 250/556 (44%), Gaps = 49/556 (8%)
Query: 89 DSDEGDGAIKYTISGEGAGTIFLIDELTGD--IHAMERLDREQKTFYTLRAQARDRATNR 146
D+ + + + Y I+G F + + + ++ LDRE++ Y L A T+
Sbjct: 2952 DTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITA----TDG 3007
Query: 147 LLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARL 206
L ++ + V D+ND+ P Y + E P+ +++V A DAD GS+ +
Sbjct: 3008 LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDAD---IGSNGYI 3064
Query: 207 VYSVL-DGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTI 265
YS+ G F +DP++G ++T LDRE Y ++ +ATD GG + + +
Sbjct: 3065 RYSLYGSGNSEFFLDPESGELKTLAL-LDRERIPVYSLMAKATDG----GGRFCQSNIHL 3119
Query: 266 VVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGD 325
++ DVNDNPP F Y + E+ + RV+A D D+G N + Y L D S G
Sbjct: 3120 ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLAD---SAGG 3176
Query: 326 VFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAV 385
VF + D+ II++++ LD E Q + + + A ++ + L T V + V
Sbjct: 3177 VFSI----DSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTT------VTITV 3226
Query: 386 TDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPD-AANRPVRYAIDRESDLDQIFD 443
D+ D PP F L+ V ED G+ V V A D N + Y I R + F
Sbjct: 3227 LDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLI-RSGNEQGKFK 3285
Query: 444 IDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATP- 502
I+ TG I + LD E + V A + A + A++ I + DVNDNPP+ +
Sbjct: 3286 INPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDV 3345
Query: 503 YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLV-----PEAPSNPHFSLLDIQDNT 557
Y A + EDA G + + D D G + +F +V E +P L+ ++
Sbjct: 3346 YSAVISEDALVGDSVILLIAEDVDSQPNG-QIHFSIVNGDRDNEFTVDPVLGLVKVKKK- 3403
Query: 558 AAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGC-DSSGTIQSCNTTAF 616
+R+ + L + VDSG P +SST T+ I I D+S N TA
Sbjct: 3404 ---------LDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAV 3454
Query: 617 VMAASLSPGALIALLV 632
+ +++ L+V
Sbjct: 3455 IQENKPVGTSILQLVV 3470
Score = 168 bits (426), Expect = 2e-41
Identities = 156/512 (30%), Positives = 232/512 (45%), Gaps = 49/512 (9%)
Query: 89 DSDEG-DGAIKYTI-SGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNR 146
D D G DG I+Y+I G G G F ID+ +G I A + LDRE Y L A DR
Sbjct: 1069 DEDSGRDGEIQYSIRDGSGLGR-FSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
Query: 147 LLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARL 206
L E I+V+D+ND+ P Y V E SP SV+Q+ A +DP S+ +L
Sbjct: 1128 LYST-IEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQA---EDPDSSSNEKL 1183
Query: 207 VYSVLDG--EHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVT 264
Y + G ++ F ++ KTG+I T LDRE Q + + + TD G + V
Sbjct: 1184 TYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTD--GGPSPKQSTIWVV 1241
Query: 265 IVVTDVNDNPPRFPQKMYQFSIQE--SAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSS 322
+ V D NDN P+FP+K+YQ + E G + R A D D G N +++Y + D
Sbjct: 1242 VQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVD---- 1297
Query: 323 GGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVR 382
G D K D T +V R F + + ++A+ D G + + R
Sbjct: 1298 GNDDGKFFIDPKTG----MVSSRKQFTAGSYDILTIKAV---------DNGRPQKSSTAR 1344
Query: 383 VAVTDVDEPP------EFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRES 436
+ + + +PP F P V E +V +VGVV+ + AN P+ + I
Sbjct: 1345 LHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQ---PANTPLWFDI-VGG 1400
Query: 437 DLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNP 496
+ D FD + G IV K LD E +N++V E + ++ + I++LD NDN
Sbjct: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSV---EVTDGTNVAVTQVFIKVLDNNDNG 1457
Query: 497 PELATP-YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQD 555
PE + P Y+ + ED P I I DRDE H+ + V + + I
Sbjct: 1458 PEFSQPNYDVTISEDVLPDTEILQIEATDRDEK---HKLSY-TVHSSIDSISMRKFRIDP 1513
Query: 556 NTAAVHTQHVGFNRQEQDVFFLPILVVDSGPP 587
+T ++T + + QD L I+V D P
Sbjct: 1514 STGVLYTAE-RLDHEAQDKHILNIMVRDQEFP 1544
Score = 156 bits (395), Expect = 7e-38
Identities = 143/544 (26%), Positives = 253/544 (46%), Gaps = 45/544 (8%)
Query: 100 TISGE----GAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFI 155
T++GE G IF+I++ TG I +RLDRE + + A + +
Sbjct: 2742 TVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVD 2801
Query: 156 IKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGE- 214
IKV D+ND++P F Y + E P GT + QV A D D +G++ ++ YS+
Sbjct: 2802 IKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMD---WGANGQVTYSLHSDSQ 2858
Query: 215 -----HHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTD 269
F +D TG I T + DLD E+ + + A+D+ G+ LS + V++ VTD
Sbjct: 2859 PEKVMEAFNIDSNTGWIST-LKDLDHETDPTFTFSVVASDL-GEAFSLSSTALVSVRVTD 2916
Query: 270 VNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGE-NTDMTYHLKDESSSGGDVFK 328
+NDN P F Q++Y+ +++ES P G V + D D + N ++YH+ + G +
Sbjct: 2917 INDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRG----R 2972
Query: 329 VTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDV 388
E + V++ LD E Q ++ + + A + G F QA+V V+V+DV
Sbjct: 2973 FALGLVQSEWKVYVKRPLDREEQDIYFLNITATD----------GLFVTQAMVEVSVSDV 3022
Query: 389 -DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPD-AANRPVRYAIDRESDLDQIFDIDA 446
D P + + ED ++ V+A+D D +N +RY++ + + F +D
Sbjct: 3023 NDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSE--FFLDP 3080
Query: 447 DTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATP-YEA 505
++G + T LDRE +++ +A D + ++++ + + DVNDNPP ++ Y
Sbjct: 3081 ESGELKTLALLDRERIPVYSL--MAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNT 3138
Query: 506 AVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHV 565
V E+ L+ + VD D + + L A FS+ D+++ +
Sbjct: 3139 CVYENTATKALLTRVQAVDPDIGI-NRKVVYSLADSA--GGVFSI----DSSSGIIILEQ 3191
Query: 566 GFNRQEQDVFFLPILVVDSGP-PTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSP 624
+R++Q + + + D P +LSS T+TI + + + + + SP
Sbjct: 3192 PLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSP 3251
Query: 625 GALI 628
G +
Sbjct: 3252 GTQV 3255
Score = 152 bits (385), Expect = 9e-37
Identities = 137/463 (29%), Positives = 227/463 (49%), Gaps = 31/463 (6%)
Query: 72 VEEYTGTEPLYVGKIHSDSDEG-DGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQK 130
V E T T+ L D D G + + Y+++ + AG +F ID +G I + LDREQ+
Sbjct: 3140 VYENTATKALLTRVQAVDPDIGINRKVVYSLA-DSAGGVFSIDSSSGIIILEQPLDREQQ 3198
Query: 131 TFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQV 190
+ Y + +A D++ + L + I V DIND+ P F Y+ +V E + GT V+ V
Sbjct: 3199 SSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAV 3258
Query: 191 MASDADDPTYGSSARLVYSVLDGEHH--FTVDPKTGVIRTAVPDLDRESQERYEVVIQAT 248
A+ D G++A + Y + G F ++PKTG I + LD E +R+ +V++A
Sbjct: 3259 FATSKD---IGTNAEITYLIRSGNEQGKFKINPKTGGISVS-EVLDYELCKRFYLVVEAK 3314
Query: 249 DMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGE 308
D G LS TV I +TDVNDNPP+F Q +Y I E A +G +V + AED D
Sbjct: 3315 D--GGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQP 3372
Query: 309 NTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPR 368
N + H + + F V D ++ V+K+LD E ++++++A++
Sbjct: 3373 NGQI--HFSIVNGDRDNEFTV----DPVLGLVKVKKKLDRERVSGYSLLVQAVD------ 3420
Query: 369 FADLGTFRDQAIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGS--LVGVVTARDPDAAN 425
+ + A V + ++DV D P F P + +QE+ VG+ L VVT RD
Sbjct: 3421 -SGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNG 3479
Query: 426 RPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASL 485
P ++I + ++ F +D G + + + + + V A ++ Q+S +
Sbjct: 3480 PPFSFSI-LSGNEEEEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYI 3537
Query: 486 RIRILDVNDNPPELATPYEAAV--CEDAKPGQLIQTISVVDRD 526
R+R+++ + + P A P E + ED PG +I I D+D
Sbjct: 3538 RVRVIEESTHKP-TAIPLEIFIVTMEDDFPGGVIGKIHATDQD 3579
Score = 148 bits (373), Expect = 2e-35
Identities = 142/510 (27%), Positives = 234/510 (45%), Gaps = 31/510 (6%)
Query: 86 IHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATN 145
I++ S EG G I I G+ F ID TG + + LD E + Y L +A D T
Sbjct: 2208 INATSPEGQGIIYIIIDGDPFKQ-FNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTG 2266
Query: 146 RLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGS-SA 204
E + + V D+ND+ P F Y +++E S GT V+QV++ DAD
Sbjct: 2267 ARAEVTVDLL--VNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHY 2324
Query: 205 RLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVT 264
++V + +F +D +G+I TA LD E + + +++ D LS V
Sbjct: 2325 QIVQDTYNSTDYFHIDSSSGLILTARM-LDHELVQHCTLKVRSIDSG--FPSLSSEVLVH 2381
Query: 265 IVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGG 324
I ++DVNDNPP F Q +Y+ + E AP G V V+A D+D + + Y + SG
Sbjct: 2382 IYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL----SGN 2437
Query: 325 DVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVA 384
D + + D++ +I + +P++++ + + G F A V +
Sbjct: 2438 D--RTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD----------GLFTSTAQVHIR 2485
Query: 385 VTDVD-EPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANR-PVRYAIDRESDLDQIF 442
V + P F + + EV+E+ G+ V V A D D + YAI + D+ F
Sbjct: 2486 VLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDR-F 2544
Query: 443 DIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELAT- 501
ID++ G ++T + LDRE ++++ D + + ++R+ ++D NDN P+ T
Sbjct: 2545 LIDSN-GQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTV 2603
Query: 502 PYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVH 561
Y A+V D G L+ + +D D+ R + L EA S LL+I + +
Sbjct: 2604 EYRASVRADVGRGHLVTQVQAIDPDD-GANSRITYSLYSEA-SVSVADLLEIDPDNGWMV 2661
Query: 562 TQHVGFNRQEQDVFFLPILVVDSGPPTLSS 591
T+ FN+ + V + VD G P S
Sbjct: 2662 TKG-NFNQLKNTVLSFFVKAVDGGIPVKHS 2690
Score = 147 bits (370), Expect = 5e-35
Identities = 140/514 (27%), Positives = 234/514 (45%), Gaps = 51/514 (9%)
Query: 99 YTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKV 158
Y + IF I+ +G I + LD E+ + Y L QA + A + + I++
Sbjct: 1703 YEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAG---MASNATVNIQI 1759
Query: 159 QDINDSEPRFLHGPYIGSVAELSPTGTSV-------MQVMASDADDPTYGSSARLVYSVL 211
D ND+ P FL Y GS++E +P + V + + A+DAD +A LVY ++
Sbjct: 1760 VDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADS---NRNALLVYQIV 1816
Query: 212 DG--EHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTD 269
+ + FTVD TG IRT + +LD E+ + + D V I VTD
Sbjct: 1817 ESTAKKFFTVDSSTGAIRT-IANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTD 1875
Query: 270 VNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKV 329
VNDNPP F Q +++ + +G V +V A D D ++TY L + S D F +
Sbjct: 1876 VNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSL---DHFLI 1932
Query: 330 TTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTD-V 388
D+ ++ ++ + S+ + +I++ + G F ++V + V + +
Sbjct: 1933 ----DSNSGVLTIKN--NNLSKDHYMLIVKVSD----------GKFYSTSMVTIMVKEAM 1976
Query: 389 DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADT 448
D F + E+ + V +V A + N P++Y+I + F I + +
Sbjct: 1977 DSGLHFTQSFYSTSISENNTNITKVAIVNAVG-NRLNEPLKYSILNPGNK---FKIKSTS 2032
Query: 449 GAI-VTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPE-LATPYEAA 506
G I TG DRE + + V A +H +++R +R+ I D+NDN P + PY AA
Sbjct: 2033 GVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAA 2092
Query: 507 VCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVG 566
V DA+PG LI ++ +D+D+ G Y + +I N+ V +
Sbjct: 2093 VQVDAEPGTLIYQVTAIDKDKGPNGEVTYV-------LQDDYGHFEINPNSGNVILKE-A 2144
Query: 567 FNRQEQDV-FFLPILVVDSGPPTLSSTGTLTIRI 599
FN ++ + + IL D G P+LS++ L I I
Sbjct: 2145 FNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI 2178
Score = 143 bits (360), Expect = 7e-34
Identities = 153/546 (28%), Positives = 255/546 (46%), Gaps = 45/546 (8%)
Query: 69 FFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTIS-GEGAGTIFLID--ELTGDIHAMERL 125
FF + +G L +S G+ A++ T + GE I+ L G + +
Sbjct: 623 FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFS 682
Query: 126 DREQKTFYTLRAQARDRA-TNRLLEPESEFIIKVQDINDSEPRFLHG-PYIGSVAELSPT 183
RE + L + +A N L E F+ IN P F P +V E P
Sbjct: 683 CRETRVAQKLAEKLLIKAKANGKLNLEDGFL-DFYSINRQGPYFDKSFPSDVAVKEDLPV 741
Query: 184 GTSVMQVMASDADDPTYGSSARLVYSVLDG--EHHFTVDPKTGVIRTAVPDLDRESQERY 241
G +++++ A DAD G + ++++++ DG + F +D +TG ++ +P +DRE + Y
Sbjct: 742 GANILKIKAYDADS---GFNGKVLFTISDGNTDSCFNIDMETGQLKVLMP-MDREHTDLY 797
Query: 242 EVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKA 301
+ I D+ S +TI V D NDN P F Q Y +I ES+ IGT + +V+A
Sbjct: 798 LLNITIYDLGNP--QKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEA 855
Query: 302 EDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEAL 361
D D+G N ++TY + ++ F + + + I+ V +LD ES+ +++ +EA
Sbjct: 856 RDKDLGSNGEVTYSVLTDTQQ----FAINSST----GIVYVADQLDRESKANYSLKIEAR 907
Query: 362 NKFVDPRFADLGTFRDQAI-VRVAVTDVDE-PPEFRPPSGLLEVQEDAQVGSLVGVVTAR 419
+K A+ G + ++V + DV++ P F P S ++V ED VG+++ +
Sbjct: 908 DK------AESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETH 961
Query: 420 DPD-AANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHA 478
DPD VRY++ +D + F+ID +GAI K LD E ++N+TV A +
Sbjct: 962 DPDLGLGGQVRYSL--VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPV 1019
Query: 479 QLSRAS-LRIRILDVNDNPPELATPY--EAAVCEDAKPGQLIQT--ISVVDRDEPQGGHR 533
LS S + + ++DVN+N L TPY + AV K I T + V RDE G
Sbjct: 1020 SLSSVSFVEVEVVDVNEN---LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDG 1076
Query: 534 FYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTG 593
+ + FS+ D+ + V T +R+ ++L + D G L ST
Sbjct: 1077 EIQYSIRDGSGLGRFSI----DDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTI 1132
Query: 594 TLTIRI 599
+ I +
Sbjct: 1133 EVYIEV 1138
Score = 143 bits (360), Expect = 7e-34
Identities = 138/512 (26%), Positives = 240/512 (46%), Gaps = 46/512 (8%)
Query: 99 YTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKV 158
+ I G + F ++ G I + LD EQ++ Y + + D TN + ++ IKV
Sbjct: 1395 FDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD-GTNVAV---TQVFIKV 1450
Query: 159 QDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDG--EHH 216
D ND+ P F Y +++E T ++Q+ A+D D+ S V+S +D
Sbjct: 1451 LDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYT--VHSSIDSISMRK 1508
Query: 217 FTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPR 276
F +DP TGV+ TA LD E+Q+++ + I D + V + V D ND+ P
Sbjct: 1509 FRIDPSTGVLYTA-ERLDHEAQDKHILNIMVRDQ--EFPYRRNLARVIVNVEDANDHSPY 1565
Query: 277 FPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQ 336
F +Y+ S+ ESA +G+AV +V A D D GEN ++ Y + E+ + G++FK+ +
Sbjct: 1566 FTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTI--EAGNTGNMFKI----EPV 1619
Query: 337 EAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEP-PEFR 395
II + K D + + ++ ++ P A AIVR++VT D P+F
Sbjct: 1620 LGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSA-------TAIVRISVTMSDNSHPKFI 1672
Query: 396 PPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGK 455
EV E+ +G+ V +++A + + Y + ++ D++ IF I+ +G I T K
Sbjct: 1673 HKDYQAEVNENVDIGTSVILISA----ISQSTLIYEV-KDGDINGIFTINPYSGVITTQK 1727
Query: 456 GLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPE-LATPYEAAVCEDAKPG 514
LD E + + + A A S A++ I+I+D NDN P L + Y ++ E A
Sbjct: 1728 ALDYERTSSYQLIIQATNMAGMA--SNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPIN 1785
Query: 515 QLIQT-------ISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGF 567
++++ I D D + Y + E+ + F+ + +T A+ T
Sbjct: 1786 SIVRSLDNSPLVIRATDADSNRNALLVY--QIVESTAKKFFT---VDSSTGAIRT-IANL 1839
Query: 568 NRQEQDVFFLPILVVDSGPPTLSSTGTLTIRI 599
+ + F + V DSG P L++ + + I
Sbjct: 1840 DHETIAHFHFHVHVRDSGSPQLTAESPVEVNI 1871
Score = 142 bits (357), Expect = 2e-33
Identities = 152/556 (27%), Positives = 233/556 (41%), Gaps = 43/556 (7%)
Query: 89 DSDEG-DGAIKYTISG----EGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRA 143
D D G +G + Y++ E F ID TG I ++ LD E +T A D
Sbjct: 2840 DMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLG 2899
Query: 144 TNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSS 203
L + ++V DIND+ P F Y G+V E P G V + D D T +
Sbjct: 2900 EAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRD--TSDVN 2957
Query: 204 ARLVYSVLDG--EHHFTVDPKTGVIRTAVP-DLDRESQERYEVVIQATDMAGQLGGLSGS 260
++ Y + G F + + V LDRE Q+ Y + I ATD G
Sbjct: 2958 RQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATD-----GLFVTQ 3012
Query: 261 TTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDES 320
V + V+DVNDN P Q Y + E P + +V A+D+D+G N + Y L
Sbjct: 3013 AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL---Y 3069
Query: 321 SSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAI 380
SG F + +S + + + LD E PV++++ +A D G Q+
Sbjct: 3070 GSGNSEFFLDPESGELKTLAL----LDRERIPVYSLMAKA---------TDGGGRFCQSN 3116
Query: 381 VRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPD-AANRPVRYAIDRESDL 438
+ + + DV D PP F V E+ +L+ V A DPD NR V Y++
Sbjct: 3117 IHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSL--ADSA 3174
Query: 439 DQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSR-ASLRIRILDVNDNPP 497
+F ID+ +G I+ + LDRE +NI+V A + LS ++ I +LD+NDNPP
Sbjct: 3175 GGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPP 3234
Query: 498 EL-ATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDN 556
Y V ED PG + + +D Y L+ F I
Sbjct: 3235 VFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITY--LIRSGNEQGKFK---INPK 3289
Query: 557 TAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAF 616
T + V + + F+L + D G P LS+ T+ I + + + S + +
Sbjct: 3290 TGGISVSEV-LDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSA 3348
Query: 617 VMAASLSPGALIALLV 632
V++ G + LL+
Sbjct: 3349 VISEDALVGDSVILLI 3364
Score = 115 bits (289), Expect = 1e-25
Identities = 131/547 (23%), Positives = 233/547 (42%), Gaps = 62/547 (11%)
Query: 80 PLYVGKIHSDSDEGDGA----IKYTISGEGAGTIFLIDELTGDIHAMER-LDREQKTFYT 134
P V I +++ D + + Y I+ F I+ TG I R LDREQ+ +
Sbjct: 1162 PKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHF 1221
Query: 135 LRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELS--PTGTSVMQVMA 192
L D + + +++V D ND++P+F Y + E G + + A
Sbjct: 1222 LEVTVTDGGPSPK-QSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFA 1280
Query: 193 SDADDPTYGSSARLVYSVLDG--EHHFTVDPKTGVIRTAVPDLDRESQERYEVV-IQATD 249
D D+ G +A + YS++DG + F +DPKTG++ + + + Y+++ I+A D
Sbjct: 1281 FDRDE---GPNAEISYSIVDGNDDGKFFIDPKTGMVSSR----KQFTAGSYDILTIKAVD 1333
Query: 250 MAGQLGGLSGSTTVTIVVTDVNDNPPR-----FPQKMYQFSIQESAPIGTAVGRVKAEDS 304
G S+T + + + PP F + Y F++ ES + VG V + +
Sbjct: 1334 N----GRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPA 1389
Query: 305 DVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKF 364
NT + + + G F D++ IV+ K LD E + ++ + +E +
Sbjct: 1390 ----NTPLWFDIV------GGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD-- 1437
Query: 365 VDPRFADLGTFRDQAIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDA 423
GT V + V D D PEF P+ + + ED + + + A D D
Sbjct: 1438 --------GTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
Query: 424 ANRPVRYAIDRESDLDQI----FDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQ 479
++ + Y + S +D I F ID TG + T + LD E H + ++ + + +
Sbjct: 1490 KHK-LSYTV--HSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYR 1546
Query: 480 LSRASLRIRILDVNDNPPELATP-YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRL 538
+ A + + + D ND+ P P YEA+V E A G + ++ +D+D+ + Y
Sbjct: 1547 RNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIY--T 1604
Query: 539 VPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIR 598
+ + F + + + T + F L I V D G P +S+T + I
Sbjct: 1605 IEAGNTGNMFKI----EPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRIS 1660
Query: 599 ICGCDSS 605
+ D+S
Sbjct: 1661 VTMSDNS 1667
Score = 105 bits (263), Expect = 1e-22
Identities = 114/454 (25%), Positives = 199/454 (43%), Gaps = 37/454 (8%)
Query: 89 DSDEG-DGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTF-YTLRAQARDRATNR 146
D D+G +G + Y + + F I+ +G++ E + + Y + A+D
Sbjct: 2110 DKDKGPNGEVTYVLQDDYGH--FEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPS 2167
Query: 147 LLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARL 206
L + + + +N + P F Y SV E T ++ + A+ + +
Sbjct: 2168 L---STSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE------GQGI 2218
Query: 207 VYSVLDGE--HHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVT 264
+Y ++DG+ F +D TGV++ P LD E Y++ I+A+D L G TV
Sbjct: 2219 IYIIIDGDPFKQFNIDFDTGVLKVVSP-LDYEVTSAYKLTIRASDA---LTGARAEVTVD 2274
Query: 265 IVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGG 324
++V DVNDNPP F Q Y ++ E++ IGT V +V + D+D N + Y + ++ +
Sbjct: 2275 LLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNST 2334
Query: 325 DVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVA 384
D F + D+ +I+ + LD E T+ + + +D F L + + +V +
Sbjct: 2335 DYFHI----DSSSGLILTARMLDHELVQHCTLKVRS----IDSGFPSLSS---EVLVHIY 2383
Query: 385 VTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAAN-RPVRYAIDRESDLDQIF 442
++DV D PP F V E A G V V A D D+++ + Y+I +D F
Sbjct: 2384 ISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTS-F 2442
Query: 443 DIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELA-T 501
+D+ +G I + +++ V + S A + IR+L N P + +
Sbjct: 2443 LMDSKSGVITLSNHRKQRMEPLYSLNV---SVSDGLFTSTAQVHIRVLGANLYSPAFSQS 2499
Query: 502 PYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFY 535
Y A V E+ G + + D D G Y
Sbjct: 2500 TYVAEVRENVAAGTKVIHVRATDGDPGTYGQISY 2533
Score = 101 bits (251), Expect = 3e-21
Identities = 113/411 (27%), Positives = 173/411 (42%), Gaps = 48/411 (11%)
Query: 166 PRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHH-------FT 218
P F Y ++AE + G++V D S + +S ++GE F
Sbjct: 2706 PSFTQSQYSFTIAEDTAIGSTV--------DTLRILPSQNVWFSTVNGERPENNKGGIFV 2757
Query: 219 VDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFP 278
++ +TG I+ LDRE+ + + AT ++ + + V I V D+NDN P F
Sbjct: 2758 IEQETGTIKLD-KRLDRETSPAFHFKVAATIPLDKVD-IVFTVDVDIKVLDLNDNKPVFE 2815
Query: 279 QKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEA 338
Y I E P+GT + +V+A D D G N +TY L +S + DS+T
Sbjct: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNT--G 2873
Query: 339 IIVVQKRLDFESQPVHTVILEALNKFVDPRFADLG---TFRDQAIVRVAVTDV-DEPPEF 394
I K LD E+ P T + A +DLG + A+V V VTD+ D P F
Sbjct: 2874 WISTLKDLDHETDPTFTFSVVA---------SDLGEAFSLSSTALVSVRVTDINDNAPVF 2924
Query: 395 RPPSGLLEVQEDAQVGSLVGVVTA--RDPDAANRPVRYAIDRESDLDQI-FDIDADTGAI 451
V+E G +V V++ RD NR V Y I + + + +
Sbjct: 2925 AQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKV 2984
Query: 452 VTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPEL-ATPYEAAVCED 510
+ LDRE +I L + A + +++A + + + DVNDN P Y A + ED
Sbjct: 2985 YVKRPLDREE---QDIYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPED 3041
Query: 511 AKPGQLIQTISVVDRDEPQGGHRFY---------FRLVPEAPSNPHFSLLD 552
++I +S D D G+ Y F L PE+ +LLD
Sbjct: 3042 IPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLD 3092
Score = 95.9 bits (237), Expect = 1e-19
Identities = 142/581 (24%), Positives = 232/581 (39%), Gaps = 98/581 (16%)
Query: 79 EPLYVGKIHSDSDEG-DGAIKYT--ISGEGAGTIFLIDE--LTGDIHAMERLDREQKTF- 132
EP Y D D+G +G I+ ++G+ FL E + ER + ++F
Sbjct: 279 EPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFP 338
Query: 133 --YTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQV 190
Y L QA+D+ + + I + RF Y S++E SP G V V
Sbjct: 339 YGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIV 398
Query: 191 MASDADDPTYGSSARLVYSVLDGEH--HFTVDPKTGVIRTAVPDLDRESQERYEVVIQAT 248
S + Y + GE +F ++P++G+I TA P L+ +E Y+ ++ T
Sbjct: 399 KLSP-------EPIDVEYKLSPGEDAVYFKINPRSGLIVTARP-LNTVKKEVYK--LEVT 448
Query: 249 DMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGE 308
+ G L VTI + D ND+ P F Q +Y + ES P+GT+V V A D D GE
Sbjct: 449 NKEGDL-----KAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGE 503
Query: 309 NTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPR 368
N +TY + + + + T +I + LDFES P + +F+ R
Sbjct: 504 NGYITYSIASLNLLPFVINQFT-------GVISTTEELDFESSP-------EIYRFI-VR 548
Query: 369 FADLGT-FRDQAIVRVAV---TDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAA 424
+D G+ +R ++ V V + D P F + + D VG + V+A D D
Sbjct: 549 ASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDEL 608
Query: 425 NRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRE--TAGWHNITVLAMEADN------ 476
V+Y I ++L F ++ D+G + K L G + + A + +N
Sbjct: 609 EL-VKYKIISGNELG-FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMS 666
Query: 477 ------HAQLSRASLRIR------------------------------ILDVNDNPP--E 498
H ++S S R +N P +
Sbjct: 667 INISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFD 726
Query: 499 LATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTA 558
+ P + AV ED G I I D D G + + + ++ F+ +D++
Sbjct: 727 KSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLF--TISDGNTDSCFN-IDMETGQL 783
Query: 559 AVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRI 599
V + +R+ D++ L I + D G P SS LTI +
Sbjct: 784 KV---LMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINV 821
Score = 94.7 bits (234), Expect = 3e-19
Identities = 113/421 (26%), Positives = 188/421 (44%), Gaps = 38/421 (9%)
Query: 125 LDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTG 184
L+RE + Y L + R + LE ++ I+V D+ND P F Y ++AE +P
Sbjct: 117 LNREIQDNYLLIVKGSVRGED--LEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLR 174
Query: 185 TSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVV 244
TSV QV A+DAD GS+ Y + F+V P +GVI + L+ + + RY++
Sbjct: 175 TSVAQVTATDAD---IGSNGEFYYYFKNKVDLFSVHPTSGVISLS-GRLNYDEKNRYDLE 230
Query: 245 IQATDMAGQL---GGLSGSTTVTIVVTDVNDNPPRFPQKMY-QFSIQESAPIGTAVGRVK 300
I A D +L G+S + + + + +N++ P + FS+++ V
Sbjct: 231 ILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAV----VT 286
Query: 301 AEDSDVGENTDMTYHLKDESSSGGD----VFKVTTDSDTQEAIIVVQKRLDFESQPV-HT 355
+D D G N + ++ S GD F E I +K++D+ES P +
Sbjct: 287 VDDLDDGANGE----IESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYN 342
Query: 356 VILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGV 415
+ L+A +K + + L +A+ T P F + + E + G +V +
Sbjct: 343 LTLQAKDKGSPQKCSAL-----KAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAI 397
Query: 416 VTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEAD 475
V P+ + V Y + D F I+ +G IVT + L+ + + V E D
Sbjct: 398 VKL-SPEPID--VEYKLSPGEDA-VYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGD 453
Query: 476 NHAQLSRASLRIRILDVNDNPPELATP-YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRF 534
AQ++ I I D ND+ PE P Y+A V E G + T+S D+D+ + G+
Sbjct: 454 LKAQVT-----ISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYIT 508
Query: 535 Y 535
Y
Sbjct: 509 Y 509
Score = 87.4 bits (215), Expect = 5e-17
Identities = 124/457 (27%), Positives = 184/457 (40%), Gaps = 41/457 (8%)
Query: 79 EPLYVGKIHSDSDEGDGA-IKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRA 137
EP+Y D DEG A I Y+I F ID TG + + ++ T++A
Sbjct: 1273 EPIYRA-FAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILTIKA 1331
Query: 138 QARDR----ATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMAS 193
R +T RL E+I K P P+ S T ++ V++
Sbjct: 1332 VDNGRPQKSSTARL---HIEWIKKPPP--SPIPLTFDEPFYNFTVMESDRVTEIVGVVS- 1385
Query: 194 DADDPTYGSSARLVYSVLDGEHHFTVDPKTGV--IRTAVPDLDRESQERYEVVIQATDMA 251
++ L + ++ G D + GV I A P LD E + Y + ++ TD
Sbjct: 1386 -----VQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKP-LDAEQRSIYNMSVEVTD-- 1437
Query: 252 GQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTD 311
G T V I V D NDN P F Q Y +I E T + +++A D D
Sbjct: 1438 ---GTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLS 1494
Query: 312 MTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFAD 371
T H +S S + K D T ++ +RLD E+Q H LN V R +
Sbjct: 1495 YTVHSSIDSIS---MRKFRIDPST--GVLYTAERLDHEAQDKH-----ILNIMV--RDQE 1542
Query: 372 LGTFRDQAIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPD-AANRPVR 429
R+ A V V V D D P F P V E A +GS V VTA D D N +
Sbjct: 1543 FPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELI 1602
Query: 430 YAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRI 489
Y I+ + +F I+ G I K D T G +++ + + + A +RI +
Sbjct: 1603 YTIE-AGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISV 1661
Query: 490 -LDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDR 525
+ N +P + Y+A V E+ G + IS + +
Sbjct: 1662 TMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQ 1698
Score = 69.3 bits (168), Expect = 1e-11
Identities = 116/440 (26%), Positives = 176/440 (40%), Gaps = 56/440 (12%)
Query: 109 IFLIDELTGDIHAMERLDREQKTFYTLRAQARDRAT----NRLLEPESEFIIKVQDINDS 164
+F + +G I RL+ ++K Y L A DR N + ++ + ++ IN+
Sbjct: 203 LFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH 262
Query: 165 EPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTG 224
P ++ E PT V D DD G + D F + K G
Sbjct: 263 APTIHVVTHVPFSLEKEPT---YAVVTVDDLDDGANGEIESVSIVAGDPLDQFFL-AKEG 318
Query: 225 VIRTAVPDLDRESQE------RYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFP 278
+R+ + Y + +QA D G S V I + P RF
Sbjct: 319 KWLNEYKIKERKQIDWESFPYGYNLTLQAKDK-GSPQKCSALKAVYIGNPTRDTVPIRFE 377
Query: 279 QKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDV--FKVTTDSDTQ 336
+++Y SI E +P G V VK + D+ Y L S G D FK+ S
Sbjct: 378 KEVYDVSISEFSPPGVVVAIVKLSPEPI----DVEYKL----SPGEDAVYFKINPRS--- 426
Query: 337 EAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDV-DEPPEFR 395
+IV ++P++TV E V + DL +A V +++ D D PEF+
Sbjct: 427 -GLIVT-------ARPLNTVKKEVYKLEVTNKEGDL-----KAQVTISIEDANDHTPEFQ 473
Query: 396 PPSGLLEVQEDAQVGSLVGVVTARDPDAA-NRPVRYAIDRESDLDQIFDIDADTGAIVTG 454
P V E VG+ V V+A D D N + Y+I + L F I+ TG I T
Sbjct: 474 QPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP--FVINQFTGVISTT 531
Query: 455 KGLDRETAGW-HNITVLAME-ADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCE--- 509
+ LD E++ + V A + + S ++ IRI +VNDN P +E C+
Sbjct: 532 EELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSP----LFEKVACQGVI 587
Query: 510 --DAKPGQLIQTISVVDRDE 527
D G I +S +D DE
Sbjct: 588 SYDFPVGGHITAVSAIDIDE 607
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,899,734
Number of Sequences: 37866
Number of extensions: 1943519
Number of successful extensions: 26325
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 460
Number of HSP's successfully gapped in prelim test: 153
Number of HSP's that attempted gapping in prelim test: 12971
Number of HSP's gapped (non-prelim): 5396
length of query: 828
length of database: 18,247,518
effective HSP length: 111
effective length of query: 717
effective length of database: 14,044,392
effective search space: 10069829064
effective search space used: 10069829064
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.