Search of human proteins with 166197673

Search of human proteins with 166197673

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
         (547 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|166197673 solute carrier family 22, member 15 [Homo sapiens]      1084   0.0  
gi|166064021 solute carrier family 22 (organic anion transporter...   252   7e-67
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          248   8e-66
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   242   7e-64
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           240   3e-63
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   239   4e-63
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        227   2e-59
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           222   8e-58
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          221   1e-57
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          212   6e-55
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   209   7e-54
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   208   9e-54
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   208   1e-53
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       206   3e-53
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          182   7e-46
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   164   3e-40
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   162   6e-40
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   162   7e-40
gi|157426885 organic cation transporter like 4 [Homo sapiens]         160   2e-39
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          157   2e-38
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]       152   6e-37
gi|42542386 solute carrier family 22 (organic anion/cation trans...   144   2e-34
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]       144   3e-34
gi|153791484 putative UST1-like organic anion transporter [Homo ...   143   5e-34
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          137   2e-32
gi|213021148 SVOP-like isoform 1 [Homo sapiens]                       131   1e-30
gi|24308167 SV2 related protein [Homo sapiens]                        122   8e-28
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   100   6e-21
gi|21361834 solute carrier family 22, member 17 isoform a [Homo ...    96   1e-19
gi|33457322 SVOP-like isoform 2 [Homo sapiens]                         92   1e-18

>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score = 1084 bits (2803), Expect = 0.0
 Identities = 547/547 (100%), Positives = 547/547 (100%)

Query: 1   MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQS 60
           MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQS
Sbjct: 1   MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQS 60

Query: 61  HGNQSAGEDQAFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFS 120
           HGNQSAGEDQAFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFS
Sbjct: 61  HGNQSAGEDQAFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFS 120

Query: 121 GVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMS 180
           GVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMS
Sbjct: 121 GVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMS 180

Query: 181 LVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFL 240
           LVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFL
Sbjct: 181 LVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFL 240

Query: 241 LSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFR 300
           LSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFR
Sbjct: 241 LSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFR 300

Query: 301 YRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQ 360
           YRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQ
Sbjct: 301 YRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQ 360

Query: 361 KWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYI 420
           KWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYI
Sbjct: 361 KWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYI 420

Query: 421 YTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLL 480
           YTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLL
Sbjct: 421 YTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLL 480

Query: 481 LPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEEEEEFYDAD 540
           LPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEEEEEFYDAD
Sbjct: 481 LPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEEEEEFYDAD 540

Query: 541 EETQMIK 547
           EETQMIK
Sbjct: 541 EETQMIK 547


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  252 bits (643), Expect = 7e-67
 Identities = 144/408 (35%), Positives = 221/408 (54%), Gaps = 8/408 (1%)

Query: 96  SIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIA 155
           S+ +E+ L+ +R +      S F +G+ VG + FG L DR GRK   L    L  L  +A
Sbjct: 122 SLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLA 181

Query: 156 NGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYA 215
             F PS+E +   RF V     G+S     LL E VG ++   A  +    F++G    A
Sbjct: 182 TAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLA 241

Query: 216 LLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKL 275
            L Y  R+WR L I     G ++F     +PES RWL ++GR+ EA + +   A  NR+ 
Sbjct: 242 GLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRK 301

Query: 276 KCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGS 335
                +          +G+ LDLFR+  L   TLI+  +WFV SL YYGL+L  GD G  
Sbjct: 302 LSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLD 361

Query: 336 IYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVF 395
           +Y    + G +E+P+    I+++ +  FGRK +    L LGGL C+I++F+P   D  V 
Sbjct: 362 VYLTQLIFGAVEVPARCSSIFMMQR--FGRKWSQLGTLVLGGLMCIIIIFIP--ADLPVV 417

Query: 396 AVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSL 455
             +    L+++GK+  +AAF I Y+Y++EL+PT++R  G+G   +FSR+GGI+ P +  L
Sbjct: 418 VTM----LAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILL 473

Query: 456 KYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRR 503
                +LP +++G+  + +GLL  LLPET    L +T  DL++  + R
Sbjct: 474 GEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPR 521


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  248 bits (634), Expect = 8e-66
 Identities = 158/431 (36%), Positives = 230/431 (53%), Gaps = 15/431 (3%)

Query: 80  NGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRK 139
           +G E  + V+ S+    + +EW L+   ++KV   +S FF GV +G    GQLSDRFGRK
Sbjct: 115 DGWEFSQDVYLST----VVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRK 170

Query: 140 KVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALA 199
            V     A+   F+    FS S+E F V   +VGM      +VAF+L  E +G +   + 
Sbjct: 171 NVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIF 230

Query: 200 GSIGGL-FFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRL 258
            ++G   FFAVG     L  YFIR WR L + + + G +   L  FIPESPRWL SQ R 
Sbjct: 231 STLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRF 290

Query: 259 SEAEEALYLIAKRNRKL--KCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWF 316
            EAE+ +   AK N        F      N   ++    LDLFR R +   T++ + +W 
Sbjct: 291 REAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWM 350

Query: 317 VCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLG 376
           + S+ Y+ L+L A +L G  Y N  LS LIEIP+Y     L+  +   R+  ++A L  G
Sbjct: 351 LTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLL--RTLPRRYIIAAVLFWG 408

Query: 377 GLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLG 436
           G   L +  +P      V     S  L +LGK  I++AF+++Y++T+ELYPT++RN+ +G
Sbjct: 409 GGVLLFIQLVP------VDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVG 462

Query: 437 TCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDL 496
             S  SRVG IIAP+   L      LP+IV G+  +  G+L+L  PE+L   L ET   +
Sbjct: 463 VTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQM 522

Query: 497 QVYSYRRLGEE 507
           Q   + R G++
Sbjct: 523 QKVKWFRSGKK 533


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  242 bits (617), Expect = 7e-64
 Identities = 183/539 (33%), Positives = 267/539 (49%), Gaps = 55/539 (10%)

Query: 1   MEVEEAFQAVGEMGIYQMYLCFLLA---VLLQLY-------VATEAILIALVGATPSY-H 49
           M  EE  + VG  G +Q+    LLA   VLL L+        A  A   AL GA  ++ H
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60

Query: 50  WDL----------------------AELLPNQSHGN--QSAGEDQAFGDWLLTANGSEIH 85
            D+                       + LPN + G   QS GE +     +  + G E +
Sbjct: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWE-Y 119

Query: 86  KHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTG 145
            H  FSS+   IA+EW L+  +     AAS+FFF+GV VG ++FG LSDRFGR+++ L  
Sbjct: 120 DHSEFSST---IATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVA 176

Query: 146 FALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGL 205
           +   ++  +A+  S SY  FA+TR L G    G +++   L  E +   +  +AG +   
Sbjct: 177 YVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSST 236

Query: 206 FFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEAL 265
           F+  G+   AL+GY IR WR L + V L      L   ++PES RWL +QG + EA   L
Sbjct: 237 FWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYL 296

Query: 266 YLIAKRNRKLKCTFSLTHPA-------NRSCRETGSFLDLFRYRVLLGHTLILMFIWFVC 318
              A+ N +  C  S +  A        R  R   S+LDLFR   L   +L  + +WF  
Sbjct: 297 LHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRP-SYLDLFRTPRLRHISLCCVVVWFGV 355

Query: 319 SLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGL 378
           +  YYGL+L    LG ++Y    L G +E+PS  L +YL + ++ GR+ T +  L   G 
Sbjct: 356 NFSYYGLSLDVSGLGLNVYQTQLLFGAVELPS-KLLVYL-SVRYAGRRLTQAGTLL--GT 411

Query: 379 ACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTC 438
           A      L    D   ++ V    L+++GK    AAF   Y++TSELYPTV+R  G+G  
Sbjct: 412 ALAFGTRLLVSSDMKSWSTV----LAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLT 467

Query: 439 SMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497
           ++  R+GG +AP    L  V  SLP + +G   L +   +LLLPET  + L ET  D++
Sbjct: 468 ALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVE 526


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  240 bits (612), Expect = 3e-63
 Identities = 149/422 (35%), Positives = 228/422 (54%), Gaps = 17/422 (4%)

Query: 80  NGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRK 139
           +G E  + V+ S+    I +EW L+    +K     S FF GV +G    GQLSDRFGRK
Sbjct: 115 DGWEFSQDVYLST----IVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRK 170

Query: 140 KVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALA 199
            V      +   F+    FS ++E F V   LVGM      + AFVL  E +G +   + 
Sbjct: 171 NVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIF 230

Query: 200 GSIGG-LFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRL 258
            ++G  +F+A G     L  YFIR WR L + + + G +   L  FIPESPRWL SQGR 
Sbjct: 231 STLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRF 290

Query: 259 SEAEEALYLIAKRNRKL--KCTFSLTHPANRSCRETGS--FLDLFRYRVLLGHTLILMFI 314
            EAE  +   AK N  +     F  +   + S ++  S   LDL R   +   T++ + +
Sbjct: 291 EEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIML 350

Query: 315 WFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLC 374
           W   S+ Y+GL+L   +L G I+ N  LS ++E+P+Y L   L+  ++  R+ +++  L 
Sbjct: 351 WMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLL--QYLPRRYSMATALF 408

Query: 375 LGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVG 434
           LGG   L +  +P   D    A V    L ++GK  ++AAF++VY+YT+ELYPTV+RN+G
Sbjct: 409 LGGSVLLFMQLVPP--DLYYLATV----LVMVGKFGVTAAFSMVYVYTAELYPTVVRNMG 462

Query: 435 LGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFS 494
           +G  S  SR+G I++P+   L      LP+I+ G+  + + +L+L LPE+  +PL +T  
Sbjct: 463 VGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTID 522

Query: 495 DL 496
            +
Sbjct: 523 QM 524


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  239 bits (611), Expect = 4e-63
 Identities = 181/539 (33%), Positives = 266/539 (49%), Gaps = 53/539 (9%)

Query: 1   MEVEEAFQAVGEMGIYQMYLCFLLA---VLLQLY-------VATEAILIALVGATPSY-H 49
           M  EE  + VG  G +Q+    LLA   VLL L+        A  A   AL GA  ++ H
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60

Query: 50  WDL----------------------AELLPNQSHGN--QSAGEDQAFGDWLLTANGSEIH 85
            D+                       + LPN + G   QS GE +     +  + G E +
Sbjct: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWE-Y 119

Query: 86  KHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTG 145
            H  FSS+  +  S+W L+  +     AAS+FFF+GV VG ++FG LSDRFGR+++ L  
Sbjct: 120 DHSEFSSTIAT-ESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVA 178

Query: 146 FALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGL 205
           +   ++  +A+  S SY  FA+TR L G    G +++   L  E +   +  +AG +   
Sbjct: 179 YVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSST 238

Query: 206 FFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEAL 265
           F+  G+   AL+GY IR WR L + V L      L   ++PES RWL +QG + EA   L
Sbjct: 239 FWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYL 298

Query: 266 YLIAKRNRKLKCTFSLTHPA-------NRSCRETGSFLDLFRYRVLLGHTLILMFIWFVC 318
              A+ N +  C  S +  A        R  R   S+LDLFR   L   +L  + +WF  
Sbjct: 299 LHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRP-SYLDLFRTPRLRHISLCCVVVWFGV 357

Query: 319 SLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGL 378
           +  YYGL+L    LG ++Y    L G +E+PS  L +YL + ++ GR+ T +  L   G 
Sbjct: 358 NFSYYGLSLDVSGLGLNVYQTQLLFGAVELPS-KLLVYL-SVRYAGRRLTQAGTLL--GT 413

Query: 379 ACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTC 438
           A      L    D   ++ V    L+++GK    AAF   Y++TSELYPTV+R  G+G  
Sbjct: 414 ALAFGTRLLVSSDMKSWSTV----LAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLT 469

Query: 439 SMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497
           ++  R+GG +AP    L  V  SLP + +G   L +   +LLLPET  + L ET  D++
Sbjct: 470 ALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVE 528


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  227 bits (578), Expect = 2e-59
 Identities = 150/459 (32%), Positives = 238/459 (51%), Gaps = 29/459 (6%)

Query: 50  WDLAELLPNQSHGNQSAGEDQAFGDWLLTANGSE---IHKHVHFSSSFTSIA-SEWFLIA 105
           W+L+    N+     S G +        T +  E   +  +++  +++ S A ++W L+ 
Sbjct: 96  WELSRCSRNKRENTSSLGYEY-------TGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVC 148

Query: 106 NRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFF 165
           +R +        F  GV +G ++FG  SDR GR+ V     +   LF IA  F+  Y  F
Sbjct: 149 DRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTF 208

Query: 166 AVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWR 225
              RF + M+  G  +V FV + E +G      A      FFAVG    AL GY +R+W 
Sbjct: 209 MAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWW 268

Query: 226 TLAILVNLQGTVVFLLSLFI-PESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFS---- 280
              ++++   TV F+L  ++ PE+P WL S+GR  EA++ + ++AK NR   C  S    
Sbjct: 269 LYQMILSTV-TVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLS 327

Query: 281 --LTHPANRSCRETG--SFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSI 336
             L  P + S  E    +   LF    +   TL +  IWF  SL +Y  +L++ +LGG+ 
Sbjct: 328 LDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNE 387

Query: 337 YANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFA 396
           Y NL L G++EIP+Y      +++   GR+  L+  L    LAC +VM +P+K    +  
Sbjct: 388 YLNLFLLGVVEIPAYTFVCIAMDK--VGRRTVLAYSLFCSALACGVVMVIPQKHY--ILG 443

Query: 397 VVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLK 456
           VV +    ++GK  I AAF ++Y+YT+ELYPT++R++ +G+ SM  R+  I+APF   L 
Sbjct: 444 VVTA----MVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLS 499

Query: 457 YVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSD 495
            +   +P +  G   L SG+L+L LPETL   L  T+ +
Sbjct: 500 SIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEE 538


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  222 bits (565), Expect = 8e-58
 Identities = 175/559 (31%), Positives = 261/559 (46%), Gaps = 58/559 (10%)

Query: 3   VEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYH------------- 49
           V++  +  GE   +Q  + FLLA+L   + A   + I  +G TP +              
Sbjct: 5   VDDVLEHGGEFHFFQKQMFFLLALLSATF-APIYVGIVFLGFTPDHRCRSPGVAELSLRC 63

Query: 50  -WDLAELLPNQSHGNQSAGEDQAFG------DW------------LLTANGSEI-----H 85
            W  AE L     G   AGE           DW             L  N S +      
Sbjct: 64  GWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCR 123

Query: 86  KHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTG 145
               + +  +SI +E+ L+   S+ +    S    G F+G +S G ++DRFGRK   LT 
Sbjct: 124 DGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTT 183

Query: 146 FALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGL 205
             ++    +    SP+Y +  + R + G+++    L+ ++L+ E VG  Y    G    +
Sbjct: 184 VLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQV 243

Query: 206 FFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEAL 265
            + VG+   A + Y +  WR L   V L      L    IPESPRWL SQ + +EA   +
Sbjct: 244 AYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRII 303

Query: 266 YLIAKRNRKLKCTFSLTHPANRSCRETG-----SFLDLFRYRVLLGHTLILMFIWFVCSL 320
             IAK+N K   +   +    R   ETG     SFLDL R   +  HT+ILM+ WF  S+
Sbjct: 304 KHIAKKNGK---SLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV 360

Query: 321 VYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLAC 380
           +Y GL +  G  G +IY +   S L+E P+  + I  I++   GR+   +A   + G AC
Sbjct: 361 LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDR--IGRRYPWAASNMVAGAAC 418

Query: 381 LIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSM 440
           L  +F+P   D     ++    +S LG++ I+ A+ IV +  +ELYPT IRN+G+  CS 
Sbjct: 419 LASVFIP--GDLQWLKII----ISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSS 472

Query: 441 FSRVGGIIAPF-IPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVY 499
              +GGII PF +  L  +   LP +VFG  GL +G L LLLPET    L ET  + +  
Sbjct: 473 MCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENM 532

Query: 500 SYRRLGEEA---LSLQALD 515
              R  +E    L +Q LD
Sbjct: 533 QRPRKNKEKMIYLQVQKLD 551


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  221 bits (564), Expect = 1e-57
 Identities = 136/410 (33%), Positives = 216/410 (52%), Gaps = 11/410 (2%)

Query: 90  FSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALD 149
           ++ + ++I SE+ L+   ++ +    +    G   G  + G  +DR+GR  +YL      
Sbjct: 133 YAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGV 192

Query: 150 ILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAV 209
            +  +   F+P++  F + RFL G+   G  +  +V++ E VG+    + G +  +FF +
Sbjct: 193 GVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTL 252

Query: 210 GIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIA 269
           GI     + YFI +W+ + + + L   +  L    +PESPRWL ++ +  +A + L  IA
Sbjct: 253 GIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIA 312

Query: 270 KRNRK-LKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLS 328
           K N K L   +S     +       SFLDL R   +   TLILMF WF  ++VY GL + 
Sbjct: 313 KCNGKYLSSNYSEITVTDEEV-SNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMR 371

Query: 329 AGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPE 388
            G +GG++Y +  +SG++E+P   L +  I +   GR+   +A   + G+ACL+  FLPE
Sbjct: 372 LGIIGGNLYIDFFISGVVELPGALLILLTIER--LGRRLPFAASNIVAGVACLVTAFLPE 429

Query: 389 KKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGII 448
               G+  +    +++ LG+L I+ AF IVY+  SELYPT +RN G+  CS     GGII
Sbjct: 430 ----GIAWL--RTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGII 483

Query: 449 APFIPSLKYVQW-SLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497
           APF+       W  LP I+FG      G L +LLPET    L ET  D++
Sbjct: 484 APFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVE 533


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  212 bits (540), Expect = 6e-55
 Identities = 142/424 (33%), Positives = 215/424 (50%), Gaps = 22/424 (5%)

Query: 90  FSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALD 149
           ++S+  SI +EW L+ N +     A S F +G+ +G +  G LSDRFGR+ +    + L 
Sbjct: 101 YNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLL 160

Query: 150 ILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAV 209
                   FSP++  + V RFL G    G++L   +L  E V T   A+  +  G  +  
Sbjct: 161 AASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTF 220

Query: 210 GIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIA 269
           G      L Y I  WR L + V++   V FL S + PES RWL   G+ S+A + L  +A
Sbjct: 221 GQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVA 280

Query: 270 KRNRK-----------LKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVC 318
             N K           LK        +    + T S  DLFR  +L   T  L   WF  
Sbjct: 281 VFNGKKEEGERLSLEELKLNLQ-KEISLAKAKYTAS--DLFRIPMLRRMTFCLSLAWFAT 337

Query: 319 SLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGL 378
              YY L +   + G ++Y    + G +++P+    I +++  + GR  T +A L L G 
Sbjct: 338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPA--KFITILSLSYLGRHTTQAAALLLAGG 395

Query: 379 ACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTC 438
           A L + F+P    T V  V     L++ GK  +S++F+ +++YTSELYPTVIR  G+G  
Sbjct: 396 AILALTFVPLDLQT-VRTV-----LAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVS 449

Query: 439 SMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQV 498
           ++++RVG +++P +     VQ  +P I++G T L  G  +L LPETLN PL ET  DL+ 
Sbjct: 450 NLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLEN 509

Query: 499 YSYR 502
           +S R
Sbjct: 510 WSLR 513


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  209 bits (531), Expect = 7e-54
 Identities = 163/537 (30%), Positives = 254/537 (47%), Gaps = 53/537 (9%)

Query: 3   VEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYH------------- 49
           V++  + VGE G +Q    FL+  LL    A   + I  +G TP +H             
Sbjct: 4   VDDILEQVGESGWFQKQ-AFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRC 62

Query: 50  -WDLAELLPNQSHGNQSAGEDQAF--------GDW------------LLTANGSEI---- 84
            W  AE L     G   AGE  AF         DW             L  N S +    
Sbjct: 63  GWSPAEELNYTVPGLGPAGE--AFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP 120

Query: 85  -HKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYL 143
                 + +  +SI +E+ L+   S+K+    S   +G   G +  G  +DRFGRK   L
Sbjct: 121 CQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLL 180

Query: 144 TGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIG 203
               ++ +  +   FSP+Y    + R L G+++ G  +  + L+ E VG+        + 
Sbjct: 181 GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMY 240

Query: 204 GLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEE 263
            + F VG+     L Y +  WR L + V+L   +  L    +PESPRWL SQ R +EA +
Sbjct: 241 QMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIK 300

Query: 264 ALYLIAKRNRKLKCT--FSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLV 321
            +  IA++N KL       L+   + + + + SF DLFR   L   T ILM++WF  S++
Sbjct: 301 IMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL 360

Query: 322 YYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACL 381
           Y GL L  G   G++Y +   S L+EIP   + +  I++   GR   ++    L G ACL
Sbjct: 361 YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDR--VGRIYPMAMSNLLAGAACL 418

Query: 382 IVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMF 441
           +++F+    D     ++    +  +G++ I+ A  ++ +  +ELYPT +RN+G+  CS  
Sbjct: 419 VMIFI--SPDLHWLNII----IMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSL 472

Query: 442 SRVGGIIAPFIP-SLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497
             +GGII PFI   L+ V  +LP I+F   GL +  ++LLLPET    L ET  D +
Sbjct: 473 CDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAE 529


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  208 bits (530), Expect = 9e-54
 Identities = 158/557 (28%), Positives = 259/557 (46%), Gaps = 41/557 (7%)

Query: 1   MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHW---------- 50
           M   +  Q VG +G +Q  +   L VL  L +A+   L     A P++H           
Sbjct: 1   MAFNDLLQQVGGVGRFQQ-IQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSK 59

Query: 51  --DLAELLPNQSHGNQSAGEDQAFGDWLLT-ANGSEIHKH----------VHFSSSFTS- 96
              L   LP    G   +        W L   NG+E +            ++ +S+F S 
Sbjct: 60  NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPST 119

Query: 97  IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIAN 156
           I +EW L+ +       A S +  GV +G + FG L+DR GR+KV +  +    +     
Sbjct: 120 IVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCA 179

Query: 157 GFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYAL 216
            F+P++  +   R L GM   G+SL    L  E +     A  G++ G  +++G    A 
Sbjct: 180 AFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAG 239

Query: 217 LGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLK 276
           + Y +  WR L +LV+      F+ S F  ES RW  S GRL     AL  +A+ N K +
Sbjct: 240 VAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKRE 299

Query: 277 CTFSLTHPANRSC--------RETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLS 328
               L+    R+         +   S ++L R   L    L L  +WF  S  YYGL + 
Sbjct: 300 EGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMD 359

Query: 329 AGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPE 388
               G SIY    + G +++P+  +   +IN    GR+    A L L G+  L+   +P+
Sbjct: 360 LQGFGVSIYLIQVIFGAVDLPAKLVGFLVINS--LGRRPAQMAALLLAGICILLNGVIPQ 417

Query: 389 KKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGII 448
            +     ++V + SL++LGK  ++A+FN +++YT ELYPT+IR  G+G  S  +RVG I+
Sbjct: 418 DQ-----SIVRT-SLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIV 471

Query: 449 APFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEA 508
           +P +     +  S+P  ++GA  + +  +++LLPETL  PL +T  DL+    ++  ++ 
Sbjct: 472 SPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQTRQQQ 531

Query: 509 LSLQALDPQQCVDKESS 525
              + + P Q   +E +
Sbjct: 532 EHQKYMVPLQASAQEKN 548


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  208 bits (529), Expect = 1e-53
 Identities = 155/529 (29%), Positives = 248/529 (46%), Gaps = 41/529 (7%)

Query: 1   MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHW---------- 50
           M   +  Q VG +G +Q  +   L VL  L +A+   L     A P++H           
Sbjct: 1   MAFNDLLQQVGGVGRFQQ-IQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSK 59

Query: 51  --DLAELLPNQSHGNQSAGEDQAFGDWLLT-ANGSEIHKH----------VHFSSSFTS- 96
              L   LP    G   +        W L   NG+E +            ++ +S+F S 
Sbjct: 60  NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPST 119

Query: 97  IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIAN 156
           I +EW L+ +       A S +  GV +G + FG L+DR GR+KV +  +    +     
Sbjct: 120 IVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCA 179

Query: 157 GFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYAL 216
            F+P++  +   R L GM   G+SL    L  E +     A  G++ G  +++G    A 
Sbjct: 180 AFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAG 239

Query: 217 LGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLK 276
           + Y +  WR L +LV+      F+ S F  ES RW  S GRL     AL  +A+ N K +
Sbjct: 240 VAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKRE 299

Query: 277 CTFSLTHPANRSC--------RETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLS 328
               L+    R+         +   S ++L R   L    L L  +WF  S  YYGL + 
Sbjct: 300 EGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMD 359

Query: 329 AGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPE 388
               G SIY    + G +++P+  +   +IN    GR+    A L L G+  L+   +P+
Sbjct: 360 LQGFGVSIYLIQVIFGAVDLPAKLVGFLVINS--LGRRPAQMAALLLAGICILLNGVIPQ 417

Query: 389 KKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGII 448
            +     ++V + SL++LGK  ++A+FN +++YT ELYPT+IR  G+G  S  +RVG I+
Sbjct: 418 DQ-----SIVRT-SLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIV 471

Query: 449 APFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497
           +P +     +  S+P  ++GA  + +  +++LLPETL  PL +T  DL+
Sbjct: 472 SPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLE 520


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  206 bits (525), Expect = 3e-53
 Identities = 136/411 (33%), Positives = 207/411 (50%), Gaps = 16/411 (3%)

Query: 95  TSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAI 154
           ++I  EW L+         A S + +GV VG   FG L+DR G K   +  +        
Sbjct: 120 STIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGA 179

Query: 155 ANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQY 214
           A  +  S+  + V RFL+GM   G+ L +  L+ E + T    +AG + G  F +G    
Sbjct: 180 ATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLIL 239

Query: 215 ALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRK 274
           A + Y IR WR L   ++    + FL S ++PES RWL   G+   A + L  +A  N +
Sbjct: 240 AGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGR 299

Query: 275 LKCTFSLTHPANRSCRET--------GSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLT 326
            +    LT     S  ++         S LDLFR   +   T  LM IWF  S+ YYGL 
Sbjct: 300 KEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLA 359

Query: 327 LSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFL 386
           +     G S+Y   AL G+I  P+  + +      + GR+ T+++FL L GL  +  MF+
Sbjct: 360 MDLQKFGLSLYLVQALFGIINTPA--MLVATATMIYVGRRATVASFLILAGLMVIANMFV 417

Query: 387 PEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGG 446
           PE   T +     +     LGK  ++++F  VY++T ELYPT IR +G+G  S+ +R+GG
Sbjct: 418 PE--GTQILCTAQA----ALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGG 471

Query: 447 IIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497
           + AP + +L      LP + FGAT + +GL   +L ET N PL+ET + ++
Sbjct: 472 LTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAME 522


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  182 bits (462), Expect = 7e-46
 Identities = 132/440 (30%), Positives = 208/440 (47%), Gaps = 17/440 (3%)

Query: 88  VHFSSSFTS-IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGF 146
           V+  S FTS I ++W L+ +       A S + +G+ VG  + G  SDRFGR+ V    +
Sbjct: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180

Query: 147 ALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLF 206
               +   A  F+P++  + + RFL+     G+ +    LL E        L  ++  L 
Sbjct: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240

Query: 207 FAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALY 266
           F+ G    A + Y +R W  L ++V++   + FL S ++ ES RWL + GRL    + L+
Sbjct: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300

Query: 267 LIAKRNRKLKCTFSLTHPANRSC--------RETGSFLDLFRYRVLLGHTLILMFIWFVC 318
            +A  N K     +LT     S         +   S   L R   L   T I    WF  
Sbjct: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360

Query: 319 SLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGL 378
              ++GL L    LG +I+      G+++IP+    + L++    GR+ TL+A L L GL
Sbjct: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSH--LGRRPTLAASLLLAGL 418

Query: 379 ACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTC 438
             L    +P +        + S +L++LG   + AAF  + IY+SEL+PTV+R   +G  
Sbjct: 419 CILANTLVPHE-----MGALRS-ALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLG 472

Query: 439 SMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQV 498
            M +R G I+ P +  L      LP +V+G   + SGL +LLLPET + PL +T  D+Q 
Sbjct: 473 QMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQN 532

Query: 499 YSYRRLGEEALSLQALDPQQ 518
            + ++     L    L   Q
Sbjct: 533 QAVKKATHGTLGNSVLKSTQ 552


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  164 bits (414), Expect = 3e-40
 Identities = 135/473 (28%), Positives = 216/473 (45%), Gaps = 52/473 (10%)

Query: 3   VEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYH------------- 49
           V++  + VGE G +Q    FL+  LL    A   + I  +G TP +H             
Sbjct: 4   VDDILEQVGESGWFQKQ-AFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRC 62

Query: 50  -WDLAELLPNQSHGNQSAGEDQAF--------GDW------------LLTANGSEI---- 84
            W  AE L     G   AGE  AF         DW             L  N S +    
Sbjct: 63  GWSPAEELNYTVPGLGPAGE--AFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP 120

Query: 85  -HKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYL 143
                 + +  +SI +E+ L+   S+K+    S   +G   G +  G  +DRFGRK   L
Sbjct: 121 CQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLL 180

Query: 144 TGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIG 203
               ++ +  +   FSP+Y    + R L G+++ G  +  + L+ E VG+        + 
Sbjct: 181 GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMY 240

Query: 204 GLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEE 263
            + F VG+     L Y +  WR L + V+L   +  L    +PESPRWL SQ R +EA +
Sbjct: 241 QMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIK 300

Query: 264 ALYLIAKRNRKLKCT--FSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLV 321
            +  IA++N KL       L+   + + + + SF DLFR   L   T ILM++WF  S++
Sbjct: 301 IMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL 360

Query: 322 YYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACL 381
           Y GL L  G   G++Y +   S L+EIP   + +  I++   GR   ++    L G ACL
Sbjct: 361 YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDR--VGRIYPMAMSNLLAGAACL 418

Query: 382 IVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVG 434
           +++F+    D     ++    +  +G++ I+ A  ++ +  +ELYPT +  VG
Sbjct: 419 VMIFI--SPDLHWLNII----IMCVGRMGITIAIQMICLVNAELYPTFVSGVG 465


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  162 bits (411), Expect = 6e-40
 Identities = 147/557 (26%), Positives = 236/557 (42%), Gaps = 85/557 (15%)

Query: 1   MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHW---------- 50
           M   +  Q VG +G +Q  +   L VL  L +A+   L     A P++H           
Sbjct: 1   MAFNDLLQQVGGVGRFQQ-IQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSK 59

Query: 51  --DLAELLPNQSHGNQSAGEDQAFGDWLLT-ANGSEIHKH----------VHFSSSFTS- 96
              L   LP    G   +        W L   NG+E +            ++ +S+F S 
Sbjct: 60  NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPST 119

Query: 97  IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIAN 156
           I +EW L+ +       A S +  GV +G + FG L+DR GR+KV +  +    +     
Sbjct: 120 IVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCA 179

Query: 157 GFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYAL 216
            F+P++  +   R L GM   G+SL    L  E +     A  G++ G  +++G    A 
Sbjct: 180 AFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAG 239

Query: 217 LGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLK 276
           + Y +  WR L +LV+      F+ S F  ES RW  S GRL     AL  +A+ N K +
Sbjct: 240 VAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKRE 299

Query: 277 CTFSLTHPANRSC--------RETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLS 328
               L+    R+         +   S ++L R   L    L L  +WF  S  YYGL + 
Sbjct: 300 EGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMD 359

Query: 329 AGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPE 388
               G SIY    + G +++P+  +   +IN    GR+    A L L G+  L+   +P+
Sbjct: 360 LQGFGVSIYLIQVIFGAVDLPAKLVGFLVINS--LGRRPAQMAALLLAGICILLNGVIPQ 417

Query: 389 KKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGII 448
            +     ++V + SL++LGK  ++A+FN +++YT ELYPT+IR V               
Sbjct: 418 DQ-----SIVRT-SLAVLGKGCLAASFNCIFLYTGELYPTMIRAV--------------- 456

Query: 449 APFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEA 508
                                        ++LLPETL  PL +T  DL+    ++  ++ 
Sbjct: 457 -----------------------------TVLLPETLGQPLPDTVQDLESRKGKQTRQQQ 487

Query: 509 LSLQALDPQQCVDKESS 525
              + + P Q   +E +
Sbjct: 488 EHQKYMVPLQASAQEKN 504


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  162 bits (410), Expect = 7e-40
 Identities = 144/529 (27%), Positives = 225/529 (42%), Gaps = 85/529 (16%)

Query: 1   MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHW---------- 50
           M   +  Q VG +G +Q  +   L VL  L +A+   L     A P++H           
Sbjct: 1   MAFNDLLQQVGGVGRFQQ-IQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSK 59

Query: 51  --DLAELLPNQSHGNQSAGEDQAFGDWLLT-ANGSEIHKH----------VHFSSSFTS- 96
              L   LP    G   +        W L   NG+E +            ++ +S+F S 
Sbjct: 60  NGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPST 119

Query: 97  IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIAN 156
           I +EW L+ +       A S +  GV +G + FG L+DR GR+KV +  +    +     
Sbjct: 120 IVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCA 179

Query: 157 GFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYAL 216
            F+P++  +   R L GM   G+SL    L  E +     A  G++ G  +++G    A 
Sbjct: 180 AFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAG 239

Query: 217 LGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLK 276
           + Y +  WR L +LV+      F+ S F  ES RW  S GRL     AL  +A+ N K +
Sbjct: 240 VAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKRE 299

Query: 277 CTFSLTHPANRSC--------RETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLS 328
               L+    R+         +   S ++L R   L    L L  +WF  S  YYGL + 
Sbjct: 300 EGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMD 359

Query: 329 AGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPE 388
               G SIY    + G +++P+  +   +IN    GR+    A L L G+  L+   +P+
Sbjct: 360 LQGFGVSIYLIQVIFGAVDLPAKLVGFLVINS--LGRRPAQMAALLLAGICILLNGVIPQ 417

Query: 389 KKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGII 448
            +     ++V + SL++LGK  ++A+FN +++YT ELYPT+IR V               
Sbjct: 418 DQ-----SIVRT-SLAVLGKGCLAASFNCIFLYTGELYPTMIRAV--------------- 456

Query: 449 APFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497
                                        ++LLPETL  PL +T  DL+
Sbjct: 457 -----------------------------TVLLPETLGQPLPDTVQDLE 476


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score =  160 bits (406), Expect = 2e-39
 Identities = 117/415 (28%), Positives = 196/415 (47%), Gaps = 26/415 (6%)

Query: 96  SIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIA 155
           S+ +E+ L+     K   A   F +G+ +G + F  ++D+ GR    L      I+F   
Sbjct: 168 SLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFG 227

Query: 156 NGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYA 215
             F  S+  +   RF +     G ++ +  L  E +   + A A  +G  FFAVG     
Sbjct: 228 TAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLT 287

Query: 216 LLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKL 275
            + Y +  W+ L ++  +           +PESPRWL  +G++ EA++ L   A  N+K 
Sbjct: 288 GIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKT 347

Query: 276 ---KCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDL 332
                   L  P  +  R   S LD  + R L   TL++  +WF  S  Y+ L+L   +L
Sbjct: 348 IPSNLLDELQLPRKKVTR--ASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMREL 405

Query: 333 GGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKD- 391
           G S++    +  ++E+P+   CI+L+ Q   GRK +L+  L    + CL+++FLPE +D 
Sbjct: 406 GVSVHFRHVVPSIMEVPARLCCIFLLQQ--IGRKWSLAVTLLQAIIWCLLLLFLPEGEDG 463

Query: 392 --------TGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSR 443
                           +  + +L + +++A   + ++YT+EL PTV+R  GLG  S+ S 
Sbjct: 464 LRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASV 523

Query: 444 VGGIIAPFI----PSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFS 494
            G I++  I    PSL      LP  +     + +  LS LLPET + PL E+ +
Sbjct: 524 AGAILSLTIISQTPSL------LPIFLCCVLAIVAFSLSSLLPETRDQPLSESLN 572


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  157 bits (397), Expect = 2e-38
 Identities = 123/422 (29%), Positives = 199/422 (47%), Gaps = 23/422 (5%)

Query: 88  VHFSSSFTS-IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGF 146
           V+  S FTS I ++W L+ +       + S F SG+ VG   +G LS RFGRK + L+  
Sbjct: 118 VYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPM-LSWC 176

Query: 147 ALDILFA-IANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGL 205
            L +  A  +  F+P++  +   RF+      G+ L +  L+ E   T+  A+  ++ G 
Sbjct: 177 CLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGC 236

Query: 206 FFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEAL 265
            F+ G A    L + +R WRTL +  ++    + L+S ++PES RWL  +G+  +A + L
Sbjct: 237 AFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQEL 296

Query: 266 YLIAK-------RNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVC 318
             +A+       +N  ++   S       S +E  S LDLF   VL   +  ++ + F  
Sbjct: 297 RKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSL 356

Query: 319 SLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGL 378
            + YYGL      LG  I+   AL G ++         L++  + GR+   +    + GL
Sbjct: 357 LISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLS--FLGRRTIQAGSQAMAGL 414

Query: 379 ACLIVMFLPEKKDT--GVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLG 436
           A L  M +P+   T   VFAV        LGK     +   + IY +EL+PT +R    G
Sbjct: 415 AILANMLVPQDLQTLRVVFAV--------LGKGCFGISLTCLTIYKAELFPTPVRMTADG 466

Query: 437 TCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSL-LLPETLNSPLLETFSD 495
                 R+G ++ P I   +     LP +++G   + S L+ L  LPET   PL +T  D
Sbjct: 467 ILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQD 526

Query: 496 LQ 497
           L+
Sbjct: 527 LE 528


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score =  152 bits (385), Expect = 6e-37
 Identities = 146/547 (26%), Positives = 232/547 (42%), Gaps = 66/547 (12%)

Query: 1   MEVEEAFQAVGEMGIYQM-YLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQ 59
           M  EE    VG +G +QM +L F+L  L+ L      +L     A P +   +  L  N 
Sbjct: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLI--PHILLENFAAAIPGHRCWVHMLDNNT 58

Query: 60  SHGNQSA--GEDQAFG--------------------DWLLTANGSEIHKH---------- 87
             GN++    ED                         W L      IH            
Sbjct: 59  GSGNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVD 118

Query: 88  --VHFSSSFTS-IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLT 144
             V+  S F S I ++W L+ +     S       +G+ VG I  G +SDRFGR+ +   
Sbjct: 119 GWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRW 178

Query: 145 GFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGG 204
                 +      F+P++  + V RFL G  +        ++ N  +    W    S   
Sbjct: 179 CLLQLAITDTCAAFAPTFPVYCVLRFLAGFSS------MIIISNNSLPITEWIRPNSKAL 232

Query: 205 LFF----AVGIAQYAL--LGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRL 258
           +      A+ I Q  L  L Y  R W+TL ++ ++   V FLLS ++ ES RWL    +L
Sbjct: 233 VVILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKL 292

Query: 259 SEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETG--------SFLDLFRYRVLLGHTLI 310
            E  +AL  +A+ N       +L     RS  +          +  DLFR   +     I
Sbjct: 293 DEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICI 352

Query: 311 LMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLS 370
           L+F+ F  ++ +YG  ++   +G +I+    L G + +     C+ L+     GR+ +  
Sbjct: 353 LVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVAL--IVRCLALLTLNHMGRRISQI 410

Query: 371 AFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVI 430
            F+ L GL+ L   F+P++  T   A      L+ LG    +A F+ V ++  EL PTV+
Sbjct: 411 LFMFLVGLSILANTFVPKEMQTLRVA------LACLGIGCSAATFSSVAVHFIELIPTVL 464

Query: 431 RNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLL 490
           R    G     SR+G  +AP + +L     +LP+I++G   +  GL+  LLPET N PL 
Sbjct: 465 RARASGIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLP 524

Query: 491 ETFSDLQ 497
           +T  D++
Sbjct: 525 DTIKDVE 531


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score =  144 bits (363), Expect = 2e-34
 Identities = 107/421 (25%), Positives = 188/421 (44%), Gaps = 20/421 (4%)

Query: 84  IHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYL 143
           ++  + FSS+   I +EW L+ +     S A   F +G+ VG I  G LSDRFGR+ V  
Sbjct: 121 VYDRISFSST---IVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLR 177

Query: 144 TGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIG 203
             +    +       +P++  +   RFL G+    +     +L+ E     + A+  ++G
Sbjct: 178 WCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLG 237

Query: 204 GLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEE 263
                +     A L + IR W  L ++V++   V+FL S ++ ES RWL    +  E  +
Sbjct: 238 MCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLK 297

Query: 264 ALYLIAKRNRKLKCTFSLTHPANRSC---------RETGSFLDLFRYRVLLGHTLILMFI 314
            L   A R+       +LT    +S          ++  S  ++     +     +L F 
Sbjct: 298 ELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFT 357

Query: 315 WFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLC 374
            F   + Y+GL L    LG +++    L G + + +   C+     K+  R+ +    + 
Sbjct: 358 RFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLAN--CVAPWALKYMNRRASQMLLMF 415

Query: 375 LGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVG 434
           L  +  L ++F+P++  T          L+ LG    + A  + + + +E+ PT+IR   
Sbjct: 416 LLAICLLAIIFVPQEMQT------LREVLATLGLGASALANTLAFAHGNEVIPTIIRARA 469

Query: 435 LGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFS 494
           +G  + F+ + G +AP +  L      LP+I++G     SG   LLLPET N PL +T  
Sbjct: 470 MGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQ 529

Query: 495 D 495
           D
Sbjct: 530 D 530


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score =  144 bits (362), Expect = 3e-34
 Identities = 122/421 (28%), Positives = 190/421 (45%), Gaps = 28/421 (6%)

Query: 91  SSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDI 150
           SS  ++I +EW L+       S   S F +G  +G + +G LSDR GRK +    F    
Sbjct: 125 SSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLA 184

Query: 151 LFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGS----IGGLF 206
           +      F+P++  + + RFL G     +    F+L  E      W L  S    I  L 
Sbjct: 185 ISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLE------WTLPRSRSMTIMVLL 238

Query: 207 FAVGIAQYAL--LGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEA 264
            +  + Q  L  L + I+ W  L + V+    V+FL S  + ES RWL    +L E  + 
Sbjct: 239 CSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKE 298

Query: 265 LYLIAKRNRKLKCTFSLTHPANRSC--------RETGSFLDLFRYRVLLGHTLILMFIWF 316
           L  +A  N K     +LT    RS         R   S   LFR   L      L F+ F
Sbjct: 299 LRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRF 358

Query: 317 VCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLG 376
             ++ +YGL L+   LG ++     L G +   +   C+ L+     GR+ +   F    
Sbjct: 359 AITVPFYGLILNLQHLGSNVSLFQILCGAVTFTAR--CVSLLTLNHMGRRISQILFTFPV 416

Query: 377 GLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLG 436
           GL  L+  FLP++    +  VV    L+ LG  ++SAA N   ++ +EL PT++R+   G
Sbjct: 417 GLFILVNTFLPQEMQ--ILRVV----LATLGIGSVSAASNSASVHHNELVPTILRSTVAG 470

Query: 437 TCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDL 496
             ++  R G  +AP + +L      LP+I +G   + +  + LLLPET + PL  T  D+
Sbjct: 471 INAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDV 530

Query: 497 Q 497
           +
Sbjct: 531 E 531


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  143 bits (360), Expect = 5e-34
 Identities = 117/421 (27%), Positives = 192/421 (45%), Gaps = 21/421 (4%)

Query: 88  VHFSSSFTS-IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGF 146
           V+  SSF S I ++W L+       S A   F +G+ VG   +G LSDRFGRK V    +
Sbjct: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180

Query: 147 ALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLF 206
               +      F+P+   +   RFL G     + +   +L+ E +   + A+A ++    
Sbjct: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240

Query: 207 FAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALY 266
            ++G      L + IR    L ++++    V FL S ++ ES RWL    +  E  + L 
Sbjct: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300

Query: 267 LIAKRNRKLKCTFSLTHPANRS--------CRETGSFLDLFRYRVLLGHTLILMFIWFVC 318
             A RN        LT    +S         ++  S  +L R   +      L F+ F  
Sbjct: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360

Query: 319 SLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGL 378
           ++ ++GLTL    LG +++    L G + + +  +  + +N       R LS  L +  L
Sbjct: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNH----MSRRLSQMLLMFLL 416

Query: 379 A-CLI-VMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLG 436
           A CL+ ++F+P++  T    VV    L+ LG    S          +EL P++IR    G
Sbjct: 417 ATCLLAIIFVPQEMQT--LRVV----LATLGVGAASLGITCSTAQENELIPSIIRGRATG 470

Query: 437 TCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDL 496
               F+ +GG +A  +  L      LP+I++G   + SGL+ LLLPET N PLL++  D+
Sbjct: 471 ITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDV 530

Query: 497 Q 497
           +
Sbjct: 531 E 531


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  137 bits (346), Expect = 2e-32
 Identities = 101/329 (30%), Positives = 157/329 (47%), Gaps = 16/329 (4%)

Query: 198 LAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGR 257
           L  ++  L F+ G    A + Y +R W  L ++V++   + FL S ++ ES RWL + GR
Sbjct: 11  LVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGR 70

Query: 258 LSEAEEALYLIAKRNRKLKCTFSLTHPANRSC--------RETGSFLDLFRYRVLLGHTL 309
           L    + L+ +A  N K     +LT     S         +   S   L R   L   T 
Sbjct: 71  LDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTC 130

Query: 310 ILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTL 369
           I    WF     ++GL L    LG +I+      G+++IP+    + L++    GR+ TL
Sbjct: 131 ISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSH--LGRRPTL 188

Query: 370 SAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTV 429
           +A L L GL  L    +P +        + S +L++LG   + AAF  + IY+SEL+PTV
Sbjct: 189 AASLLLAGLCILANTLVPHE-----MGALRS-ALAVLGLGGVGAAFTCITIYSSELFPTV 242

Query: 430 IRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPL 489
           +R   +G   M +R G I+ P +  L      LP +V+G   + SGL +LLLPET + PL
Sbjct: 243 LRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPL 302

Query: 490 LETFSDLQVYSYRRLGEEALSLQALDPQQ 518
            +T  D+Q  + ++     L    L   Q
Sbjct: 303 PDTIQDVQNQAVKKATHGTLGNSVLKSTQ 331


>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
          Length = 492

 Score =  131 bits (330), Expect = 1e-30
 Identities = 117/398 (29%), Positives = 174/398 (43%), Gaps = 65/398 (16%)

Query: 97  IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIAN 156
           I  EW L    +++V+  ++  F G  V  I FG L+DR+GR K+ L  F     F++  
Sbjct: 75  IRCEWQL---ENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLT 131

Query: 157 GFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYAL 216
            F+PSY +F   R +VG    G S    ++  E + T Y      +  +F+  G      
Sbjct: 132 SFAPSYIWFVFLRTMVGCGVSGHSQ-GLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIG 190

Query: 217 LGYFIR---SWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNR 273
           L   I     WR L  + ++ G ++ +   FIPES R+  S G    A   L  +AK NR
Sbjct: 191 LASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNR 250

Query: 274 KLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDL- 332
            +     L  P      + G F DL   + L   TL +  IW   S  YYG+ L++ +L 
Sbjct: 251 SVMPEGKLVEPV---LEKRGRFADLLDAKYLRT-TLQIWVIWLGISFAYYGVILASAELL 306

Query: 333 -----------------GG----------------SIYANLALSGLIEIPSYPLCIYLIN 359
                            GG                S Y  + +S + EI   PL I  IN
Sbjct: 307 ERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGIN 366

Query: 360 QKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKL-----TISAA 414
             + GR+ +LS  +      C  + FL           + + S  L+G L      ++A 
Sbjct: 367 --FLGRRLSLSITM-----GCTALFFL--------LLNICTSSAGLIGFLFMLRALVAAN 411

Query: 415 FNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFI 452
           FN VYIYT+E+YPT +R +G+GT     R+G ++APFI
Sbjct: 412 FNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFI 449


>gi|24308167 SV2 related protein [Homo sapiens]
          Length = 548

 Score =  122 bits (306), Expect = 8e-28
 Identities = 126/445 (28%), Positives = 189/445 (42%), Gaps = 67/445 (15%)

Query: 100 EWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDIL----FAIA 155
           EW L    S++V+  +S  F G+      +G +SD++GRK    TG  + +L    + I 
Sbjct: 114 EWRL---PSWQVALLTSVVFVGMMSSSTLWGNISDQYGRK----TGLKISVLWTLYYGIL 166

Query: 156 NGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYA 215
           + F+P Y +  V R LVG   GG+   +  L  E +     A    +  +F+A+G     
Sbjct: 167 SAFAPVYSWILVLRGLVGFGIGGVPQ-SVTLYAEFLPMKARAKCILLIEVFWAIGTVFEV 225

Query: 216 LLGYFIR---SWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRN 272
           +L  F+     WR L IL  +   +  +L  ++PES R+    G   +A   L  IA  N
Sbjct: 226 VLAVFVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATEN 285

Query: 273 RKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTL----- 327
                   L         + G   DLF        TL+L FIWF  +  YYGL L     
Sbjct: 286 G---APMPLGKLIISRQEDRGKMRDLFTPH-FRWTTLLLWFIWFSNAFSYYGLVLLTTEL 341

Query: 328 -SAGDLGG---------------------SIYANLALSGLIEIPSYPLCIYLINQKWFGR 365
             AGD+ G                       Y +L  + L E P   + +++I++   GR
Sbjct: 342 FQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDR--LGR 399

Query: 366 KRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLL---GKLTISAAFNIVYIYT 422
           K+T++    +     L++           F  V  + L+LL    +  IS  F   Y+YT
Sbjct: 400 KKTMALCFVIFSFCSLLL-----------FICVGRNVLTLLLFIARAFISGGFQAAYVYT 448

Query: 423 SELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLP 482
            E+YPT  R +GLGTCS  +RVG +I PFI      Q  L   V+    + SG   L   
Sbjct: 449 PEVYPTATRALGLGTCSGMARVGALITPFI-----AQVMLESSVYLTLAVYSGCCLLAAL 503

Query: 483 ETLNSPLLETFSDLQVYSYRRLGEE 507
            +   P+      LQ  S+R  G+E
Sbjct: 504 ASCFLPIETKGRGLQESSHREWGQE 528


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 109/421 (25%), Positives = 176/421 (41%), Gaps = 35/421 (8%)

Query: 95  TSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAI 154
           T+   +W L+ +  ++V      F  G   G +  G  +DRFGR+ + L    L     +
Sbjct: 84  TNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGV 143

Query: 155 ANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVL-LNECVGTAYW--ALAG---SIGGLFFA 208
               + S       RFL+G +  G+ L  +++ L  C  T     ALAG    +GG F  
Sbjct: 144 GGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLF 203

Query: 209 VGIAQYALLGYFIRSWRTLAILVNLQGTVVFLL----SLFIPESPRWLYSQGRLSEAEEA 264
           +G+A  +      + WR L  ++     ++FL      LF+ ES RWL  + ++ EA+  
Sbjct: 204 LGLALVS------KDWRFLQRMITAP-CILFLFYGWPGLFL-ESARWLIVKRQIEEAQSV 255

Query: 265 LYLIAKRNR---------KLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIW 315
           L ++A+RNR           +    L +        + SF  L  YR +  + LIL F  
Sbjct: 256 LRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTN 315

Query: 316 FVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYL-INQKWFGRKRTLSAFLC 374
           F+   + +      G  GGS       S L    +   C++L +    FGR+  L   + 
Sbjct: 316 FIAHAIRHCYQPVGG--GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMT 373

Query: 375 LGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVG 434
           L G+A L+++ L +  +          + S+LG  +  AA  +  +  +E+ PT +R  G
Sbjct: 374 LTGIASLVLLGLWDYLNEAAIT-----TFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRG 428

Query: 435 LGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFS 494
           LG       +GG+  P           L  +V  A  L   L  +LLPET    L E   
Sbjct: 429 LGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLR 488

Query: 495 D 495
           D
Sbjct: 489 D 489


>gi|21361834 solute carrier family 22, member 17 isoform a [Homo
           sapiens]
          Length = 538

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 111/437 (25%), Positives = 179/437 (40%), Gaps = 49/437 (11%)

Query: 95  TSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAI 154
           T+   +W L+ +  ++V      F  G   G +  G  +DRFGR+ + L    L     +
Sbjct: 84  TNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGV 143

Query: 155 ANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVL-LNECVGTAYW--ALAG---SIGGLFFA 208
               + S       RFL+G +  G+ L  +++ L  C  T     ALAG    +GG F  
Sbjct: 144 GGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLF 203

Query: 209 VGIAQYALLGYFIRSWRTLAILVNLQGTVVFLL----SLFIPESPRWLYSQGRLSEAEEA 264
           +G+A  +      + WR L  ++     ++FL      LF+ ES RWL  + ++ EA+  
Sbjct: 204 LGLALVS------KDWRFLQRMITAP-CILFLFYGWPGLFL-ESARWLIVKRQIEEAQSV 255

Query: 265 LYLIAKRNR---------KLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIW 315
           L ++A+RNR           +    L +        + SF  L  YR +  + LIL F  
Sbjct: 256 LRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTN 315

Query: 316 FVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYL-INQKWFGRKRTLSAFLC 374
           F+   + +      G  GGS       S L    +   C++L +    FGR+  L   + 
Sbjct: 316 FIAHAIRHCYQPVGG--GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMT 373

Query: 375 LGGLACLIVMFLPE----------------KKDTGVFAVVNSHSLSLLGKLTISAAFNIV 418
           L G+A L+++ L +                 +D    A+    + S+LG  +  AA  + 
Sbjct: 374 LTGIASLVLLGLWDCEHPIFPTVWAQQGNPNRDLNEAAIT---TFSVLGLFSSQAAAILS 430

Query: 419 YIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLS 478
            +  +E+ PT +R  GLG       +GG+  P           L  +V  A  L   L  
Sbjct: 431 TLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSI 490

Query: 479 LLLPETLNSPLLETFSD 495
           +LLPET    L E   D
Sbjct: 491 MLLPETKRKLLPEVLRD 507


>gi|33457322 SVOP-like isoform 2 [Homo sapiens]
          Length = 340

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 87/297 (29%), Positives = 129/297 (43%), Gaps = 66/297 (22%)

Query: 195 YWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYS 254
           +W LAGS+      +G+A   +       WR L  + ++ G ++ +   FIPES R+  S
Sbjct: 28  FW-LAGSL----LIIGLASVIIPTI---GWRWLIRVASIPGIILIVAFKFIPESARFNVS 79

Query: 255 QGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFI 314
            G    A   L  +AK NR +     L  P      + G F DL   + L   TL +  I
Sbjct: 80  TGNTRAALATLERVAKMNRSVMPEGKLVEPV---LEKRGRFADLLDAKYLRT-TLQIWVI 135

Query: 315 WFVCSLVYYGLTLSAGDL------------------GG----------------SIYANL 340
           W   S  YYG+ L++ +L                  GG                S Y  +
Sbjct: 136 WLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTM 195

Query: 341 ALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNS 400
            +S + EI   PL I  IN  + GR+ +LS  +      C  + FL           + +
Sbjct: 196 IISTIGEIALNPLNILGIN--FLGRRLSLSITM-----GCTALFFL--------LLNICT 240

Query: 401 HSLSLLGKL-----TISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFI 452
            S  L+G L      ++A FN VYIYT+E+YPT +R +G+GT     R+G ++APFI
Sbjct: 241 SSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFI 297


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.140    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,509,320
Number of Sequences: 37866
Number of extensions: 772343
Number of successful extensions: 3675
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 3449
Number of HSP's gapped (non-prelim): 121
length of query: 547
length of database: 18,247,518
effective HSP length: 107
effective length of query: 440
effective length of database: 14,195,856
effective search space: 6246176640
effective search space used: 6246176640
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.