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Search of human proteins with 166064036
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166064036 PAK-interacting exchange factor beta isoform d
[Homo sapiens]
(753 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 1522 0.0
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo... 1506 0.0
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 1498 0.0
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 1125 0.0
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ... 1125 0.0
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 786 0.0
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 136 8e-32
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 135 1e-31
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 124 4e-28
gi|71274148 pleckstrin homology domain containing, family G (wit... 117 5e-26
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 109 8e-24
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 106 9e-23
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 106 9e-23
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 103 8e-22
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 99 2e-20
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 96 2e-19
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 96 2e-19
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 87 7e-17
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 86 2e-16
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 79 1e-14
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 79 2e-14
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 79 2e-14
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 78 3e-14
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 78 3e-14
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 78 3e-14
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 78 3e-14
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 78 3e-14
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 76 1e-13
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 76 1e-13
gi|39930351 dynamin binding protein [Homo sapiens] 74 4e-13
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 1522 bits (3940), Expect = 0.0
Identities = 753/753 (100%), Positives = 753/753 (100%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKTFDAN 60
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKTFDAN
Sbjct: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKTFDAN 60
Query: 61 DLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLF 120
DLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLF
Sbjct: 61 DLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLF 120
Query: 121 QGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRT 180
QGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRT
Sbjct: 121 QGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRT 180
Query: 181 GWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKEL 240
GWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKEL
Sbjct: 181 GWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKEL 240
Query: 241 QTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCF 300
QTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCF
Sbjct: 241 QTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCF 300
Query: 301 LNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRL 360
LNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRL
Sbjct: 301 LNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRL 360
Query: 361 DKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWE 420
DKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWE
Sbjct: 361 DKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWE 420
Query: 421 GDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTG 480
GDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTG
Sbjct: 421 GDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTG 480
Query: 481 MTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPH 540
MTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPH
Sbjct: 481 MTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPH 540
Query: 541 SVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPW 600
SVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPW
Sbjct: 541 SVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPW 600
Query: 601 SLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEED 660
SLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEED
Sbjct: 601 SLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEED 660
Query: 661 AQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDL 720
AQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDL
Sbjct: 661 AQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDL 720
Query: 721 SEDSDYDSIWTAHSYRMGSTSRKSCCSYISHQN 753
SEDSDYDSIWTAHSYRMGSTSRKSCCSYISHQN
Sbjct: 721 SEDSDYDSIWTAHSYRMGSTSRKSCCSYISHQN 753
>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
sapiens]
Length = 782
Score = 1506 bits (3900), Expect = 0.0
Identities = 753/782 (96%), Positives = 753/782 (96%), Gaps = 29/782 (3%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEK----- 55
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEK
Sbjct: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
Query: 56 ------------------------TFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDS 91
TFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDS
Sbjct: 61 RSESECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDS 120
Query: 92 VCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNED 151
VCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNED
Sbjct: 121 VCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNED 180
Query: 152 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKG 211
ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKG
Sbjct: 181 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKG 240
Query: 212 FDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEE 271
FDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEE
Sbjct: 241 FDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEE 300
Query: 272 ICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE 331
ICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE
Sbjct: 301 ICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE 360
Query: 332 LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAF 391
LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAF
Sbjct: 361 LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAF 420
Query: 392 KNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 451
KNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL
Sbjct: 421 KNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 480
Query: 452 LLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN 511
LLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN
Sbjct: 481 LLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN 540
Query: 512 NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYH 571
NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYH
Sbjct: 541 NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYH 600
Query: 572 TLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMK 631
TLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMK
Sbjct: 601 TLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMK 660
Query: 632 KLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMH 691
KLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMH
Sbjct: 661 KLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMH 720
Query: 692 NHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISH 751
NHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISH
Sbjct: 721 NHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISH 780
Query: 752 QN 753
QN
Sbjct: 781 QN 782
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 1498 bits (3879), Expect = 0.0
Identities = 753/803 (93%), Positives = 753/803 (93%), Gaps = 50/803 (6%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEK----- 55
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEK
Sbjct: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
Query: 56 ---------------------------------------------TFDANDLYQGQNFNK 70
TFDANDLYQGQNFNK
Sbjct: 61 RSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNK 120
Query: 71 VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT 130
VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT
Sbjct: 121 VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT 180
Query: 131 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 190
DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE
Sbjct: 181 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 240
Query: 191 VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP 250
VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP
Sbjct: 241 VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP 300
Query: 251 LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL 310
LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL
Sbjct: 301 LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL 360
Query: 311 YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL 370
YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL
Sbjct: 361 YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL 420
Query: 371 ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV 430
ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV
Sbjct: 421 ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV 480
Query: 431 TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE 490
TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE
Sbjct: 481 TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE 540
Query: 491 NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH 550
NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH
Sbjct: 541 NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH 600
Query: 551 PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP 610
PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP
Sbjct: 601 PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP 660
Query: 611 LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY 670
LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY
Sbjct: 661 LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY 720
Query: 671 CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW 730
CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW
Sbjct: 721 CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW 780
Query: 731 TAHSYRMGSTSRKSCCSYISHQN 753
TAHSYRMGSTSRKSCCSYISHQN
Sbjct: 781 TAHSYRMGSTSRKSCCSYISHQN 803
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 1125 bits (2911), Expect = 0.0
Identities = 554/555 (99%), Positives = 555/555 (100%)
Query: 129 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 188
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
Query: 189 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 248
REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
Query: 249 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 308
RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
Query: 309 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 368
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
Query: 369 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 428
ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
Query: 429 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 488
NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
Query: 489 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 548
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
Query: 549 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 608
SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
Query: 609 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 668
PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
Query: 669 AYCTSAKTRQTLNST 683
AYCTSAKTRQTLNS+
Sbjct: 541 AYCTSAKTRQTLNSS 555
>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 1125 bits (2911), Expect = 0.0
Identities = 554/555 (99%), Positives = 555/555 (100%)
Query: 129 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 188
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
Query: 189 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 248
REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
Query: 249 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 308
RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
Query: 309 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 368
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
Query: 369 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 428
ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
Query: 429 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 488
NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
Query: 489 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 548
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
Query: 549 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 608
SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
Query: 609 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 668
PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
Query: 669 AYCTSAKTRQTLNST 683
AYCTSAKTRQTLNS+
Sbjct: 541 AYCTSAKTRQTLNSS 555
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 786 bits (2031), Expect = 0.0
Identities = 410/713 (57%), Positives = 510/713 (71%), Gaps = 74/713 (10%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEK----- 55
MN EQ VTWLI+LGVLESPKKTI DPE FL++SLK+GVVLC+L+ RL+PG++EK
Sbjct: 1 MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP 60
Query: 56 -----------------------TFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSV 92
FD +DLY G NF+KVLS+L+ +NK T D S+
Sbjct: 61 QTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATED--QLSERP 118
Query: 93 CARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDE 152
C R SS + Q + T Q Q ++++MT+N ++QL+V+A+FNF+QTNEDE
Sbjct: 119 CGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDE 178
Query: 153 LSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGF 212
LS KGD+I+VTRVEEGGWWEGTLNGRTGWFPSNYVRE+K+SE+P+SPK+ KGF
Sbjct: 179 LSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKA------VKGF 232
Query: 213 DTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEI 272
+T + K+YY VVLQNIL+TE EY+KELQ++L TYLRPLQ++ LS+ ++ L+GN EE+
Sbjct: 233 ETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEV 292
Query: 273 CSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEEL 332
C+FQQ L Q+LEEC+K PE Q +VGGC L+LMP K++YL YCANHPSAVNVLT+HS+EL
Sbjct: 293 CTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDEL 352
Query: 333 GEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 392
+FME +GASSPGIL+LTT LSKPFMRL+KY TLL+ELERHMED H D QDI K++ AFK
Sbjct: 353 EQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFK 412
Query: 393 NLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLL 452
L QCQ++RKRK+LELQIL+E I+ WEG+DIK LGNV +MSQV++Q EEK ERYL+
Sbjct: 413 TLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLM 472
Query: 453 LFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNN 512
LF NVL+MLSASPRMSGFIYQGK+P G +T+L++ E + FEI+G+ +ERI+V CNN
Sbjct: 473 LFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNN 532
Query: 513 QQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHT 572
QD QEW+E L + + P+S + SK + + + H+
Sbjct: 533 NQDFQEWLEQLNRLIR------------------------GPASCSSLSKTSSSSCSAHS 568
Query: 573 LPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKE-------DLSK 625
S G P GPLEPP+ KPWSLSCLRPAPPLRPSAAL YKE + SK
Sbjct: 569 --SFSSTGQPR-----GPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSK 621
Query: 626 SPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQ 678
SPKTMKK L KRK ERKPS+EE+ RKSTAALEEDAQILKVIEAYCTSA +Q
Sbjct: 622 SPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQ 674
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 136 bits (342), Expect = 8e-32
Identities = 128/542 (23%), Positives = 230/542 (42%), Gaps = 29/542 (5%)
Query: 91 SVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNE 150
+VCA +D L S S H + G+ +++ + + + A ++ ++
Sbjct: 152 AVCADEVGSEEDLYDDLHSSS-HHYSHPGGGGEQLAINELISDGSVVCAEALWDHVTMDD 210
Query: 151 DELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTLKS 207
EL F GDVI V WW G + GWFP+++VR ++P +P +G +
Sbjct: 211 QELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGA 270
Query: 208 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISYLM 266
G + + V+ IL TE +Y K L+ + Y+R + ++ S + +
Sbjct: 271 EDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIF 330
Query: 267 GNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA---V 322
GN+E+I Q+ V++LE+ +G CFL + +Y YC NHP+A +
Sbjct: 331 GNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACVEL 389
Query: 323 NVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQ 382
+ LT+ S+ + F + + L L P ++ KYP L EL ++ H D +
Sbjct: 390 SRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFK 449
Query: 383 DIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQC 440
D++ ++ A KN++ E ++R E ++ +I +WEG+D+ + S L +
Sbjct: 450 DVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRV 509
Query: 441 AGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH------ 492
+ K+ +R LF + L+ R Y+G+L G+ + LED ++
Sbjct: 510 TQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSI 569
Query: 493 RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHP 551
+NAF + G+ + L+ + Q W++ ++ + + T S+
Sbjct: 570 KNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET--GFSITELQRKQAM 627
Query: 552 VTPSSKHADSKPAPL-TPAYHTLPHPSHHGTPHTTINWGPL---EPPKTPKPWSLSCLRP 607
+ S + KP + P Y L H P L EP + P + S R
Sbjct: 628 LNASKQQVTGKPKAVGRPCY--LTRQKHPALPSNRPQQQVLVLAEPRRKPSTFWHSISRL 685
Query: 608 AP 609
AP
Sbjct: 686 AP 687
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 135 bits (341), Expect = 1e-31
Identities = 111/465 (23%), Positives = 207/465 (44%), Gaps = 21/465 (4%)
Query: 91 SVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNE 150
+VCA +D L S S H + G+ +++ + + + A ++ ++
Sbjct: 152 AVCADEVGSEEDLYDDLHSSS-HHYSHPGGGGEQLAINELISDGSVVCAEALWDHVTMDD 210
Query: 151 DELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTLKS 207
EL F GDVI V WW G + GWFP+++VR ++P +P +G +
Sbjct: 211 QELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGA 270
Query: 208 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISYLM 266
G + + V+ IL TE +Y K L+ + Y+R + ++ S + +
Sbjct: 271 EDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIF 330
Query: 267 GNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA---V 322
GN+E+I Q+ V++LE+ +G CFL + +Y YC NHP+A +
Sbjct: 331 GNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACVEL 389
Query: 323 NVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQ 382
+ LT+ S+ + F + + L L P ++ KYP L EL ++ H D +
Sbjct: 390 SRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFK 449
Query: 383 DIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQC 440
D++ ++ A KN++ E ++R E ++ +I +WEG+D+ + S L +
Sbjct: 450 DVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRV 509
Query: 441 AGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH------ 492
+ K+ +R LF + L+ R Y+G+L G+ + LED ++
Sbjct: 510 TQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSI 569
Query: 493 RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPT 536
+NAF + G+ + L+ + Q W++ ++ + + T
Sbjct: 570 KNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 124 bits (310), Expect = 4e-28
Identities = 104/423 (24%), Positives = 183/423 (43%), Gaps = 26/423 (6%)
Query: 122 GQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTG 181
G+ +++ + N + A ++ ++ EL F GDVI V WW G +
Sbjct: 135 GEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEA 194
Query: 182 WFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTT------AINKSYYNV-VLQNILETEN 234
WFP+++VR ++ +++ +S S + S + + + NK V++ I++TE
Sbjct: 195 WFPASFVR-LRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTER 253
Query: 235 EYSKELQTVLSTYLRPLQT-SEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ 293
Y K L+ + Y+R + + + A ++ + GN+E+I FQ+ ++ LE+ E
Sbjct: 254 VYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPH 313
Query: 294 -QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE--LGEFMETKGASSPGILVLT 350
+G CFL +Y YC NHP A L ++ F E I +
Sbjct: 314 LSEIGSCFLQNQEGF-AIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAI 372
Query: 351 TG-LSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELEL 409
G L P ++ KYP L EL ++ H D +I+ + A KN++ E RKRK +
Sbjct: 373 DGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINE-RKRKLESI 431
Query: 410 QILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-P 465
+ +I WEG DI + S L + + +R LF + L+
Sbjct: 432 DKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLL 491
Query: 466 RMSGFIYQGKLPTTGMTITKLEDSENH------RNAFEISGSMIERILVSC-NNQQDLQE 518
R Y+G+L M + L D + +NAF++ + + + C Q+D
Sbjct: 492 RRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKAR 551
Query: 519 WVE 521
W++
Sbjct: 552 WLQ 554
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 117 bits (292), Expect = 5e-26
Identities = 88/312 (28%), Positives = 152/312 (48%), Gaps = 18/312 (5%)
Query: 221 YYNVVLQNILETENEYSKELQTVLSTYLRPL--QTSEKLSSANISYLMGNLEEICSFQQM 278
Y + V+Q ILETE Y ++L++++ YL + QT L + S L GN+++I F
Sbjct: 113 YVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSE 172
Query: 279 LVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFM 336
L+Q LE C P A + CF++ + +Y YC N+P +V VLTE ++ L +F
Sbjct: 173 LLQDLENCENDPVA---IAECFVSKSEEFH-IYTQYCTNYPRSVAVLTECMRNKILAKFF 228
Query: 337 ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSA 396
+ + L L + L KP R+ KY LL E+E H++ + ++ + ++
Sbjct: 229 RERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAW 288
Query: 397 QCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLF 454
+++++ E + LQ + + NW+G D+ + G + IQ A KNER L LF
Sbjct: 289 HINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRA----KNERTLFLF 344
Query: 455 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSEN-HRNAFEISGSMIERILVSCNNQ 513
+LL+ R F Y+ + + + ++ E + F ++ V +Q
Sbjct: 345 DKLLLI--TKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQH-TVQAKSQ 401
Query: 514 QDLQEWVEHLQK 525
QD + WV HL++
Sbjct: 402 QDKRLWVLHLKR 413
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 109 bits (273), Expect = 8e-24
Identities = 96/405 (23%), Positives = 170/405 (41%), Gaps = 31/405 (7%)
Query: 152 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR-----EVKASEKPVSPKSGTLK 206
EL+F GDVI V WW G ++ GWFP+++VR E + E P ++G L
Sbjct: 26 ELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHL- 84
Query: 207 SPPKGFDTTAINKSYYN------VVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSS 259
D + + N V+ I+ TE Y K L+ + YL+ + + S
Sbjct: 85 --DPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSD 142
Query: 260 ANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANH 318
+ + GN+E+I FQ V+ LE+ + +G CFL +Y YC NH
Sbjct: 143 EQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYCNNH 201
Query: 319 PSAVNVLTE--HSEELGEFMETKGASSPGILVLTTG-LSKPFMRLDKYPTLLKELERHME 375
A L++ F E I + G L P ++ KYP L EL ++
Sbjct: 202 LDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTA 261
Query: 376 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDI-KTLGNVTY 432
H+D + + ++A +N++ Q E ++R E ++ ++ +WEG+DI + Y
Sbjct: 262 QDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIY 321
Query: 433 MSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSEN 491
++ +R LF + +++ R Y+G++ + +ED +
Sbjct: 322 TGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRD 381
Query: 492 H------RNAFEISGSMIERI-LVSCNNQQDLQEWVEHLQKQTKV 529
+NAF++ E I L ++ W+ +++ K+
Sbjct: 382 DDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKM 426
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 106 bits (264), Expect = 9e-23
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 139 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 198
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1163
Query: 199 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 258
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 1164 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1219
Query: 259 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 315
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 1220 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1278
Query: 316 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 371
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 1279 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1338
Query: 372 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 406
+ + H D ++ ++ + L +Q E + KE
Sbjct: 1339 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1373
Score = 64.7 bits (156), Expect = 3e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 140 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 195
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
Query: 196 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 229
K VSPK L S P + A Y NV N+
Sbjct: 796 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840
Score = 50.1 bits (118), Expect = 8e-06
Identities = 46/188 (24%), Positives = 82/188 (43%), Gaps = 20/188 (10%)
Query: 16 VLESPKKTISDPEGFLQASLKD--GVVLCRLLERLLPGTIEKTFDANDLYQGQNFNKVLS 73
+++ +KT+ +P G+L S + G C +E++ EK +L
Sbjct: 756 IIQVDEKTVGEP-GWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPK--------KALLP 806
Query: 74 SLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLG------SQSLHTRTSKLFQGQYRSL 127
V+L+ + S + A + ++ SF +L +S TRT + G +
Sbjct: 807 PTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRT--VSPGSVSPI 864
Query: 128 DMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNY 187
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +Y
Sbjct: 865 HGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSY 923
Query: 188 VREVKASE 195
V+ + SE
Sbjct: 924 VKIIPGSE 931
Score = 48.1 bits (113), Expect = 3e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 141 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 200
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 961 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1019
Query: 201 KSGTLKSPPK 210
KSG P+
Sbjct: 1020 KSGASNKKPE 1029
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 106 bits (264), Expect = 9e-23
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 139 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 198
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1190
Query: 199 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 258
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 1191 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1246
Query: 259 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 315
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 1247 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1305
Query: 316 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 371
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 1306 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1365
Query: 372 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 406
+ + H D ++ ++ + L +Q E + KE
Sbjct: 1366 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1400
Score = 64.7 bits (156), Expect = 3e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 140 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 195
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 196 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 229
K VSPK L S P + A Y NV N+
Sbjct: 823 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 867
Score = 50.1 bits (118), Expect = 8e-06
Identities = 46/188 (24%), Positives = 82/188 (43%), Gaps = 20/188 (10%)
Query: 16 VLESPKKTISDPEGFLQASLKD--GVVLCRLLERLLPGTIEKTFDANDLYQGQNFNKVLS 73
+++ +KT+ +P G+L S + G C +E++ EK +L
Sbjct: 783 IIQVDEKTVGEP-GWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPK--------KALLP 833
Query: 74 SLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLG------SQSLHTRTSKLFQGQYRSL 127
V+L+ + S + A + ++ SF +L +S TRT + G +
Sbjct: 834 PTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRT--VSPGSVSPI 891
Query: 128 DMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNY 187
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +Y
Sbjct: 892 HGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSY 950
Query: 188 VREVKASE 195
V+ + SE
Sbjct: 951 VKIIPGSE 958
Score = 48.1 bits (113), Expect = 3e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 141 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 200
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 988 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1046
Query: 201 KSGTLKSPPK 210
KSG P+
Sbjct: 1047 KSGASNKKPE 1056
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 103 bits (256), Expect = 8e-22
Identities = 66/271 (24%), Positives = 131/271 (48%), Gaps = 13/271 (4%)
Query: 143 FNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKS 202
+++ N+DEL+F+KG +I+V E+ WW+G +NG+ G FPSNYV+ + P
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK-LTTDMDPSQQWC 1222
Query: 203 GTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI 262
L T + Y + ++ TE Y +LQ V + +PL SE L+ +
Sbjct: 1223 SDLHLLDMLTPTERKRQGY----IHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEV 1278
Query: 263 SYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYCANHP 319
+ + N +E+ L+++L K+ + + +G +P M+ Y+ +C+
Sbjct: 1279 AMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQP-YIRFCSRQL 1337
Query: 320 SAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELERHME 375
+ ++ + ++E +F E + A P + L++ + KP R+ +YP ++K + +
Sbjct: 1338 NGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTP 1397
Query: 376 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 406
+ H D ++ ++ + L +Q E + KE
Sbjct: 1398 ENHPDHSHLKHALEKAEELCSQVNEGVREKE 1428
Score = 58.2 bits (139), Expect = 3e-08
Identities = 26/70 (37%), Positives = 44/70 (62%), Gaps = 1/70 (1%)
Query: 141 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 200
A + ++ + + +L+F +GDVI VT+ ++G WW GT+ + G FPSNYVR + +
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTK-KDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 201 KSGTLKSPPK 210
K+G+L P+
Sbjct: 1068 KTGSLGKKPE 1077
Score = 55.1 bits (131), Expect = 2e-07
Identities = 26/78 (33%), Positives = 43/78 (55%), Gaps = 9/78 (11%)
Query: 140 RAKFNFQQTNEDELSFSKGDVIHV-------TRVEEGGWWEGTLNGRTGWFPSNYVREVK 192
RA + F+ + DE++ GD++ V ++ E GW G L G+TGWFP+NY ++
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 193 ASE--KPVSPKSGTLKSP 208
+E PV P + + +P
Sbjct: 806 ENEVPAPVKPVTDSTSAP 823
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 12/92 (13%)
Query: 144 NFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGR-----TGWFPSNYVREVKASEKPV 198
++ T ++L+ + G +I + + GGWWEG L R GWFP+NYV+ + +
Sbjct: 1084 SYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKI 1143
Query: 199 SPKSGTLKSPPKGFDTTAINK--SYYNVVLQN 228
+P PPK A+ + Y+ QN
Sbjct: 1144 TP-----TEPPKSTALAAVCQVIGMYDYTAQN 1170
Score = 49.7 bits (117), Expect = 1e-05
Identities = 25/73 (34%), Positives = 42/73 (57%), Gaps = 2/73 (2%)
Query: 137 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKAS-E 195
L +A + ++ ++ L+F+K DVI V ++ WW G + G+ GWFP +YV+ +
Sbjct: 916 LQAQALYPWRAKKDNHLNFNKNDVITVLE-QQDMWWFGEVQGQKGWFPKSYVKLISGPIR 974
Query: 196 KPVSPKSGTLKSP 208
K S SG+ +SP
Sbjct: 975 KSTSMDSGSSESP 987
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 98.6 bits (244), Expect = 2e-20
Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 33/306 (10%)
Query: 225 VLQNILETENEYSKELQTVLSTYLRPLQTS------EKLSSANISYLMGNLEEICSFQQM 278
VL IL TE +Y L+ + S +L ++ + + L+ N+ L N+E+I +
Sbjct: 53 VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112
Query: 279 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 335
+ +LE C P++Q +G FL + +Y YC+NH A+ +L E ++ + F
Sbjct: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKF-CVYEEYCSNHEKALRLLVELNKIPTVRAF 171
Query: 336 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 392
+ + G + L L P R+ KYP LLKEL + H D +Q ++ A K
Sbjct: 172 LLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMK 231
Query: 393 NLSAQCQEVRKRKE-LE-LQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERY 450
+ + E +++ E LE L+ L I WEG ++ + + L++ + + ER
Sbjct: 232 TVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQ-ERA 290
Query: 451 LLLFPNVLLMLSASPRMSG---------------FIYQGKLPTTGMTITKLED--SENHR 493
LF N+L+ R++G +I++G++ T M + +ED ++ H
Sbjct: 291 FFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHS 350
Query: 494 NAFEIS 499
N + ++
Sbjct: 351 NGYTVT 356
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 95.5 bits (236), Expect = 2e-19
Identities = 84/336 (25%), Positives = 154/336 (45%), Gaps = 37/336 (11%)
Query: 225 VLQNILETENEYSKELQTVLSTYLRPL------QTSEKLSSANISYLMGNLEEICSFQQM 278
VL + +TE +Y L+ ++S +L + + + ++ + L N+E+I + +
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 279 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 335
++ +EEC P AQQ VG CFL+ + + +Y YC+NH A +L E ++ + F
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLELNKIRTIRTF 145
Query: 336 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 392
+ G + L L P R+ KYP +LKEL + H+D + +++ A K
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205
Query: 393 NLSAQCQEVRKRKELELQILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNER 449
+ + E +++ E +L++L E I WEG +I M VL++ + S ER
Sbjct: 206 AVCSNINEAKRQME-KLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS-SGNIQER 263
Query: 450 YLLLFPNVLLML----------SASPRMSGFIYQGKLPTTGMTITKLED------SENH- 492
LF N+L+ AS ++++G++ T M + ++D S H
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHI 323
Query: 493 -RNAFEISGSMIERILV-SCNNQQDLQEWVEHLQKQ 526
N ++I + + V ++ EW E + K+
Sbjct: 324 VVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 95.5 bits (236), Expect = 2e-19
Identities = 84/336 (25%), Positives = 154/336 (45%), Gaps = 37/336 (11%)
Query: 225 VLQNILETENEYSKELQTVLSTYLRPL------QTSEKLSSANISYLMGNLEEICSFQQM 278
VL + +TE +Y L+ ++S +L + + + ++ + L N+E+I + +
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 279 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 335
++ +EEC P AQQ VG CFL+ + + +Y YC+NH A +L E ++ + F
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLELNKIRTIRTF 145
Query: 336 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 392
+ G + L L P R+ KYP +LKEL + H+D + +++ A K
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205
Query: 393 NLSAQCQEVRKRKELELQILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNER 449
+ + E +++ E +L++L E I WEG +I M VL++ + S ER
Sbjct: 206 AVCSNINEAKRQME-KLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS-SGNIQER 263
Query: 450 YLLLFPNVLLML----------SASPRMSGFIYQGKLPTTGMTITKLED------SENH- 492
LF N+L+ AS ++++G++ T M + ++D S H
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHI 323
Query: 493 -RNAFEISGSMIERILV-SCNNQQDLQEWVEHLQKQ 526
N ++I + + V ++ EW E + K+
Sbjct: 324 VVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 86.7 bits (213), Expect = 7e-17
Identities = 87/373 (23%), Positives = 150/373 (40%), Gaps = 20/373 (5%)
Query: 218 NKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQ 277
+K+Y+ + + + TE Y K+L+ + S + + + + A S + N E + F
Sbjct: 539 DKAYF--IAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHT 596
Query: 278 MLVQSLEECTKLPEAQ--------QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVL---T 326
++ +E+ L E + QR+G L + MK L + H A+ L
Sbjct: 597 NFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHL-AAHLWKHSEALEALENGI 655
Query: 327 EHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQK 386
+ S L F L L T L +P RL Y +L+ L +H H D +D +
Sbjct: 656 KSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRA 715
Query: 387 SMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEK 446
++A + AQ + E Q L E ++ G D + ++ + +
Sbjct: 716 ALAEITEMVAQLHGTMIKME-NFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGL 774
Query: 447 NERYLLLFPNVLLMLSASPRMSG-FIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIER 505
+R LF +VLL S S F G+LP GMTI + ED + + G +
Sbjct: 775 QQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQR-QS 833
Query: 506 ILVSCNNQQDLQEWVEHLQKQ---TKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 562
I+V+ +++ ++++WVE +Q + +S P S P + P + D
Sbjct: 834 IIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDL 893
Query: 563 PAPLTPAYHTLPH 575
A T PH
Sbjct: 894 SASRTSLERQAPH 906
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 85.5 bits (210), Expect = 2e-16
Identities = 76/313 (24%), Positives = 145/313 (46%), Gaps = 22/313 (7%)
Query: 225 VLQNILETENEYSKELQTVLSTYLRPLQTSEKL--SSANISYLMGNLEEICSFQQMLVQS 282
V + I+ETE Y ++L++++ YL PL L S + L N+E+I F L++
Sbjct: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLED 165
Query: 283 LEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFMETKG 340
LE + + + CF+ +Y YC N+PS++ +L E S +++ +
Sbjct: 166 LENSS----SAGGIAECFVQRSEDFD-IYTLYCMNYPSSLALLRELSLSPPAALWLQERQ 220
Query: 341 ASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMED--YHTDRQDIQKSMAAFKNLSAQC 398
A L L + L KP R+ KY LL+EL +H + R+ +++++ + ++
Sbjct: 221 AQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYI 280
Query: 399 QEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSE--EKNERYLLLF 454
++++++E LQ + + W G ++ G + G ER L LF
Sbjct: 281 NDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLF 340
Query: 455 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMI--ERILVSCNN 512
+LL+ A R + Y+G + ++++ +S F++S I R L+ N
Sbjct: 341 SRMLLV--AKRRGLEYTYKGHIFCCNLSVS---ESPRDPLGFKVSDLTIPKHRHLLQAKN 395
Query: 513 QQDLQEWVEHLQK 525
Q++ + W+ LQ+
Sbjct: 396 QEEKRLWIHCLQR 408
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 79.3 bits (194), Expect = 1e-14
Identities = 80/348 (22%), Positives = 152/348 (43%), Gaps = 16/348 (4%)
Query: 190 EVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLST-YL 248
E K E+ L+ + + N+ + + +L TE Y L + Y
Sbjct: 175 ETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYC 234
Query: 249 RPLQTSEKLS--SANISYLMGNLEEICSFQ-QMLVQSLEECTKLPEAQQRVGGCFLNLMP 305
+ L+ + + S + ++ + N+ I +F + L+ LE+ + E R+G L P
Sbjct: 235 KLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAP 294
Query: 306 QMKTLYLTYCANHPSAVNVLTEHSEELGEFM----ETKGASSPGILVLTTGLSKPFMRLD 361
+K +Y Y +A+ ++ +E + +F E + G L L + +P R+
Sbjct: 295 FLK-MYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIP 353
Query: 362 KYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQE-VRKRKELELQILTEAIRNWE 420
+Y LLK+ R + D D +KS+ ++ +RK + L+ + + E
Sbjct: 354 RYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEE 413
Query: 421 GDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSG--FIYQGKLPT 478
D + + Q+L A + ERYL LF N+LL + G F + ++
Sbjct: 414 EDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGI 473
Query: 479 TGMTITKLEDSENHRNAFEISGSMIERIL-VSCNNQQDLQEWVEHLQK 525
GM I + + +E + + F++SG ER L + ++ QD +EW++ LQ+
Sbjct: 474 DGMKIVETQ-NEEYPHTFQVSGK--ERTLELQASSAQDKEEWIKALQE 518
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 79.0 bits (193), Expect = 2e-14
Identities = 77/340 (22%), Positives = 145/340 (42%), Gaps = 18/340 (5%)
Query: 225 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 284
+++ IL TE Y K+L+ + + + + + + ++ L N++ I F + ++ +E
Sbjct: 539 IVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVE 598
Query: 285 ECTKLPE---------AQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVL---TEHSEEL 332
+ L E + QR+G L M Q+K + +Y H + L T+ ++L
Sbjct: 599 QRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKE-FTSYFQRHDEVLTELEKATKRCKKL 657
Query: 333 GEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 392
+ L L T L KP RL Y LL+ L H H D D ++ A
Sbjct: 658 EAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAIT 717
Query: 393 NLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLL 452
++ Q + R E LQ LTE R+ G + ++ + + + +R
Sbjct: 718 EVTTTLQHILIRLE-NLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFF 776
Query: 453 LFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN 511
LF ++LL S S F +G LP GM + + ++ + + F I + + I+V+ +
Sbjct: 777 LFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQ-KTIVVAAS 835
Query: 512 NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHP 551
+ + ++W+ L + G T ++P T+ + P
Sbjct: 836 TRLEKEKWMLDLNSAIQAAKSGGDTAP--ALPGRTVCTRP 873
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 78.6 bits (192), Expect = 2e-14
Identities = 75/322 (23%), Positives = 154/322 (47%), Gaps = 50/322 (15%)
Query: 225 VLQNILETENEYSKELQTVLSTYLRPLQTS-EKLSSANIS---YLMGNLEEICSFQQ-ML 279
++ +++TE Y ++L+ + TYL + + E++ ++ + GN++EI F +
Sbjct: 1296 IMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIF 1355
Query: 280 VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHS-EELGEFMET 338
++ LE+ +LPE VG CF+ + + +Y+TYC N P + ++ EH+ E +
Sbjct: 1356 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSTQLILEHAGSYFDEIQQR 1411
Query: 339 KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAA-------- 390
G ++ +++ L KP R+ KY LLKEL E+ + +D + M +
Sbjct: 1412 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDA 1467
Query: 391 --FKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNE 448
L + + + EL IL E+ + W D KTL + E
Sbjct: 1468 MHLSMLEGFDENIESQGEL---ILQESFQVW---DPKTL---------------IRKGRE 1506
Query: 449 RYLLLFPNVLLM---LSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEI--SGSMI 503
R+L LF L+ + S S ++Y+ KL T+ + +T+ + + + A + + +
Sbjct: 1507 RHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSD 1566
Query: 504 ERILVSCNNQQDLQEWVEHLQK 525
+I++ ++ ++ Q+W++H+++
Sbjct: 1567 NKIVLKASSIENKQDWIKHIRE 1588
Score = 70.9 bits (172), Expect = 4e-12
Identities = 75/361 (20%), Positives = 161/361 (44%), Gaps = 38/361 (10%)
Query: 184 PSNYVREVKASEKP-VSPKSGTLKSPPKGFD------TTAINKSYYNVVLQNILETENEY 236
PS+ + + S P +P +L S D ++++ + +Y VLQ ++ETE +Y
Sbjct: 1927 PSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHY--VLQELVETERDY 1984
Query: 237 SKELQTVLSTYLRPLQTSEKLSS--ANISYLMGNLEEICSFQQ-MLVQSLEECTKLPEAQ 293
++L V+ Y+ ++ + GN+ +I + + + LE+C + PE
Sbjct: 1985 VRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPE-- 2042
Query: 294 QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGL 353
++G F+ ++ +Y+ YC N P + ++++E+ + E ++ + L LT L
Sbjct: 2043 -KLGSLFVKHERRLH-MYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHR---LQLTDLL 2097
Query: 354 SKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILT 413
KP R+ KY LLK+ ++ + D ++++++ + +C ++ L+
Sbjct: 2098 IKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQ----- 2152
Query: 414 EAIRNWEGDDIKTLGNVTYMSQVLI--QCAGSEEK-NERYLLLFPNVLLMLSASPRMSGF 470
++G I G + L+ Q AG + ER + LF +++ + GF
Sbjct: 2153 ----GFDG-KIVAQGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGF 2207
Query: 471 IYQGKLPTTGMTITKL---EDSENHRNAFEI---SGSMIERILVSCNNQQDLQEWVEHLQ 524
G L + ++ L E+ EN F + +G ++E ++ ++ Q W+ +
Sbjct: 2208 SMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEIN 2267
Query: 525 K 525
+
Sbjct: 2268 Q 2268
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 78.2 bits (191), Expect = 3e-14
Identities = 82/358 (22%), Positives = 160/358 (44%), Gaps = 54/358 (15%)
Query: 225 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI----SYLMGNLEEICSFQQ-ML 279
++ +L+TE Y ++L L TYL + + + I + GN++EI F +
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344
Query: 280 VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE-LGEFMET 338
++ LE+ +LPE VG CF+ + + +Y+TYC N P + ++ EH+ E +
Sbjct: 1345 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSNQLILEHAGTFFDEIQQR 1400
Query: 339 KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC 398
G ++ +++ L KP R+ KY LLKEL E+ + +D + M + +
Sbjct: 1401 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDA 1456
Query: 399 QEVRK----RKELELQ---ILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 451
V + L++Q IL +A + W+ + G ER+L
Sbjct: 1457 MHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------------RERHL 1498
Query: 452 LLFPNVLLMLSASPRMSG---FIYQGKLPTTGMTITKLEDSENHRNAF--EISGSMIERI 506
LF L+ SG ++Y+ KL T+ + +T+ + + + A + S +
Sbjct: 1499 FLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKT 1558
Query: 507 LVSCNNQQDLQEWVEHLQK--QTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 562
++ +N + QEW++++++ Q ++ + +P +P TP+ + +SK
Sbjct: 1559 VLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPK--------TPAKQRNNSK 1608
Score = 69.3 bits (168), Expect = 1e-11
Identities = 109/512 (21%), Positives = 210/512 (41%), Gaps = 61/512 (11%)
Query: 225 VLQNILETENEYSKELQTVLSTYLRPLQTS---EKLSSANISYLMGNLEEICSFQQ-MLV 280
VL +++TE +Y K+L V+ +++ ++ E + + + GN+ +I + + +
Sbjct: 1933 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKD-KIVFGNIHQIYDWHKDFFL 1991
Query: 281 QSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKG 340
LE+C + Q R+ F+ ++ +Y+ YC N P + ++ E+ E +
Sbjct: 1992 AELEKCI---QEQDRLAQLFIKHERKLH-IYVWYCQNKPRSEYIVAEYDAYFEEVKQEIN 2047
Query: 341 ASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQE 400
L L+ L KP R+ KY LLK+ R+ E + DI+K++ + +C +
Sbjct: 2048 QR----LTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCND 2103
Query: 401 VRKRKELELQILTEAIRNWEGD---DIKTLGNVTYMSQVLIQCAGSEEK-NERYLLLFPN 456
+ L+ +EG K L T+ V+ AG + + ER + LF
Sbjct: 2104 MMNLGRLQ---------GFEGTLTAQGKLLQQDTF--YVIELDAGMQSRTKERRVFLFEQ 2152
Query: 457 VLL---MLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQ 513
+++ +L G++++ + + + + D++ + A ++ ER+++ N
Sbjct: 2153 IVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL-MNRETSERVVLQAANA 2211
Query: 514 QDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTL 573
Q WV+ + N ++ + L S P+ K + PA L
Sbjct: 2212 DIQQAWVQDI----------NQVLETQRDFLNALQS-PIEYQRKERSTAVMRSQPA--RL 2258
Query: 574 PHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKL 633
P S P++++ G +PPK S P PPL+ S + + SP
Sbjct: 2259 PQASPR--PYSSVPAGSEKPPK-----GSSYNPPLPPLKISTS-------NGSPGFEYHQ 2304
Query: 634 LPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNH 693
+ K +D + S+ A+ +D LK E + + Q L Q L++
Sbjct: 2305 PGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQP 2364
Query: 694 VLADDDQPSLDSLGRRSSLSRLEPSDLSEDSD 725
A D P+ + S L+ L + +E SD
Sbjct: 2365 --ASDHSPAAEGWVPGSILAPLTKATAAESSD 2394
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 78.2 bits (191), Expect = 3e-14
Identities = 82/358 (22%), Positives = 160/358 (44%), Gaps = 54/358 (15%)
Query: 225 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI----SYLMGNLEEICSFQQ-ML 279
++ +L+TE Y ++L L TYL + + + I + GN++EI F +
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344
Query: 280 VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE-LGEFMET 338
++ LE+ +LPE VG CF+ + + +Y+TYC N P + ++ EH+ E +
Sbjct: 1345 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSNQLILEHAGTFFDEIQQR 1400
Query: 339 KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC 398
G ++ +++ L KP R+ KY LLKEL E+ + +D + M + +
Sbjct: 1401 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDA 1456
Query: 399 QEVRK----RKELELQ---ILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 451
V + L++Q IL +A + W+ + G ER+L
Sbjct: 1457 MHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------------RERHL 1498
Query: 452 LLFPNVLLMLSASPRMSG---FIYQGKLPTTGMTITKLEDSENHRNAF--EISGSMIERI 506
LF L+ SG ++Y+ KL T+ + +T+ + + + A + S +
Sbjct: 1499 FLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKT 1558
Query: 507 LVSCNNQQDLQEWVEHLQK--QTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 562
++ +N + QEW++++++ Q ++ + +P +P TP+ + +SK
Sbjct: 1559 VLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPK--------TPAKQRNNSK 1608
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 78.2 bits (191), Expect = 3e-14
Identities = 60/213 (28%), Positives = 95/213 (44%), Gaps = 23/213 (10%)
Query: 188 VREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTY 247
+ E+ S++ SP+ T P + V+ +LETE Y K+L ++ Y
Sbjct: 1009 LHEMNPSDQSPSPQDST--GPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERY 1066
Query: 248 LRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKL-PEAQQ------------ 294
L+PLQ L+ + L GNL E+ FQ +++LE+ +L P+ ++
Sbjct: 1067 LKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLF 1126
Query: 295 RVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELG--EFMETKGASSPGILVLTTG 352
+GG FL + K LY +CA+H VL + + F++ + L +
Sbjct: 1127 SLGGSFLYYADRFK-LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESY 1185
Query: 353 LSKPFMRLDKYPTLLKEL-----ERHMEDYHTD 380
L KP R+ KYP LL+EL E YH D
Sbjct: 1186 LIKPIQRILKYPLLLRELFALTDAESEEHYHLD 1218
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
Length = 626
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)
Query: 208 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 267
PP+ + V+Q +++TE Y K+L + YL PLQ L+ + L G
Sbjct: 11 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 70
Query: 268 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 314
+L E+ FQ++ +++LE+ + P ++ +GG FL K LY +
Sbjct: 71 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 129
Query: 315 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 372
CANH VL + + F++ + + L + L KP R+ KYP LLKEL
Sbjct: 130 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 189
Query: 373 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 403
+ + + +++ A + +++ E++K
Sbjct: 190 LTDQESEEHYHLTEALKAMEKVASHINEMQK 220
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)
Query: 208 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 267
PP+ + V+Q +++TE Y K+L + YL PLQ L+ + L G
Sbjct: 1086 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 1145
Query: 268 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 314
+L E+ FQ++ +++LE+ + P ++ +GG FL K LY +
Sbjct: 1146 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 1204
Query: 315 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 372
CANH VL + + F++ + + L + L KP R+ KYP LLKEL
Sbjct: 1205 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 1264
Query: 373 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 403
+ + + +++ A + +++ E++K
Sbjct: 1265 LTDQESEEHYHLTEALKAMEKVASHINEMQK 1295
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 76.3 bits (186), Expect = 1e-13
Identities = 111/496 (22%), Positives = 199/496 (40%), Gaps = 75/496 (15%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGF---LQASLKDGVVLCRLLERLLPGTIEKTF 57
M Q WLI VL P + P L +L+DGV+LC+LL L PG+I
Sbjct: 1 MEQWRQCGRWLIDCKVLP-PNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSI---- 55
Query: 58 DANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFD------------ 105
D D+ NF +S + L + + + D R +S FD
Sbjct: 56 DLKDI----NFRPQMSQFLCLKNIRTFLKVCHDKFGLR-NSELFDPFDLFDVRDFGKVIS 110
Query: 106 SLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTR 165
++ SLH+ + S + T+N ++ + + DE + D+
Sbjct: 111 AVSRLSLHSIAQNKGIRPFPSEETTENDDDV------YRSLEELADEHDLGE-DIYDCVP 163
Query: 166 VEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVV 225
E+GG + ++ E K G + + N
Sbjct: 164 CEDGG--------------DDIYEDIIKVEVQQPMKMGMTEDDKR------------NCC 197
Query: 226 LQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEE 285
L I ETE +Y + L+ + Y+ PL+ LS A+++ + NLE++ +++++
Sbjct: 198 LLEIQETEAKYYRTLEDIEKNYMSPLRL--VLSPADMAAVFINLEDLIKVHHSFLRAID- 254
Query: 286 CTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFM----ETKGA 341
+ + FL+ ++ +Y YC++ A N L + +F E
Sbjct: 255 -VSVMVGGSTLAKVFLDFKERL-LIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLK 312
Query: 342 SSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEV 401
G L L P R+ KY LLKEL H + +RQ +++++ A ++L+ EV
Sbjct: 313 VQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAE-RPERQQLKEALEAMQDLAMYINEV 371
Query: 402 RKRKELELQILTEAIRNWEGDDIK--TLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLL 459
++ KE L+ ++E + E +K G ++ ++ + K +RYL LF V++
Sbjct: 372 KRDKE-TLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVI 430
Query: 460 MLSASPRMSGFIYQGK 475
+ + G+ Y+ K
Sbjct: 431 VC----KRKGYSYELK 442
Score = 55.5 bits (132), Expect = 2e-07
Identities = 25/52 (48%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 141 AKFNFQQTNEDELSFSKGDVIHV-TRVE-EGGWWEGTLNGRTGWFPSNYVRE 190
A++NF + ELS +GDV+ + +R+ + GWW+G NGR GWFPS YV E
Sbjct: 784 ARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEE 835
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 75.9 bits (185), Expect = 1e-13
Identities = 116/523 (22%), Positives = 209/523 (39%), Gaps = 70/523 (13%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGF---LQASLKDGVVLCRLLERLLPGTIEKTF 57
M Q WLI VL P + P L +L+DGV+LC+LL L PG+I
Sbjct: 1 MEQWRQCGRWLIDCKVLP-PNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSI---- 55
Query: 58 DANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFD------------ 105
D D+ NF +S + L + + + D R +S FD
Sbjct: 56 DLKDI----NFRPQMSQFLCLKNIRTFLKVCHDKFGLR-NSELFDPFDLFDVRDFGKVIS 110
Query: 106 SLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTR 165
++ SLH+ + S + T+N ++ + + DE + D+
Sbjct: 111 AVSRLSLHSIAQNKGIRPFPSEETTENDDDV------YRSLEELADEHDLGE-DIYDCVP 163
Query: 166 VEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVV 225
E+GG + EV+ K G + + N
Sbjct: 164 CEDGG---------DDIYEDIIKVEVQQPMIRYMQKMGMTEDDKR------------NCC 202
Query: 226 LQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEE 285
L I ETE +Y + L+ + Y+ PL+ LS A+++ + NLE++ +++++
Sbjct: 203 LLEIQETEAKYYRTLEDIEKNYMSPLRL--VLSPADMAAVFINLEDLIKVHHSFLRAID- 259
Query: 286 CTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFM----ETKGA 341
+ + FL+ ++ +Y YC++ A N L + +F E
Sbjct: 260 -VSVMVGGSTLAKVFLDFKERL-LIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLK 317
Query: 342 SSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEV 401
G L L P R+ KY LLKEL H + +RQ +++++ A ++L+ EV
Sbjct: 318 VQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAE-RPERQQLKEALEAMQDLAMYINEV 376
Query: 402 RKRKELELQILTEAIRNWEGDDIK--TLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLL 459
++ KE L+ ++E + E +K G ++ ++ + K +RYL LF V++
Sbjct: 377 KRDKE-TLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVI 435
Query: 460 MLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSM 502
+ + G+ Y+ K + +D N+++ + G M
Sbjct: 436 VC----KRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKM 474
Score = 55.5 bits (132), Expect = 2e-07
Identities = 25/52 (48%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 141 AKFNFQQTNEDELSFSKGDVIHV-TRVE-EGGWWEGTLNGRTGWFPSNYVRE 190
A++NF + ELS +GDV+ + +R+ + GWW+G NGR GWFPS YV E
Sbjct: 823 ARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEE 874
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 74.3 bits (181), Expect = 4e-13
Identities = 48/197 (24%), Positives = 96/197 (48%), Gaps = 19/197 (9%)
Query: 225 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 284
V++ +L+TE +Y ++L+ + + P+Q ++ + + + L GN++ + + L+ +LE
Sbjct: 788 VIEELLQTERDYIRDLEMCIERIMVPMQQAQ-VPNIDFEGLFGNMQMVIKVSKQLLAALE 846
Query: 285 ECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLT--EHSEELGEFMETKGAS 342
VG FL +++ Y YC NH A+ +L E E++ + ++ A
Sbjct: 847 -------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLAD 899
Query: 343 SPGI---------LVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKN 393
+ + L + L KP R+ +YP LL EL + H D+ + ++ A K
Sbjct: 900 LKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKE 959
Query: 394 LSAQCQEVRKRKELELQ 410
++ E ++RK+L L+
Sbjct: 960 INVNINEYKRRKDLVLK 976
Score = 52.8 bits (125), Expect = 1e-06
Identities = 27/73 (36%), Positives = 38/73 (52%), Gaps = 3/73 (4%)
Query: 141 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR---EVKASEKP 197
A + FQ +EL F GD I + E GW EG+L GRTG FP +V+ + + E
Sbjct: 250 ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETM 309
Query: 198 VSPKSGTLKSPPK 210
P+ G+L P+
Sbjct: 310 ALPQEGSLARIPE 322
Score = 47.0 bits (110), Expect = 7e-05
Identities = 22/49 (44%), Positives = 28/49 (57%)
Query: 140 RAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 188
RA ++EL F +GDVI + V E GW+EG L GR G FP +V
Sbjct: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFV 199
Score = 40.8 bits (94), Expect = 0.005
Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 5/82 (6%)
Query: 115 RTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEE----GG 170
RT++ + + D ++ NQ V A + F+ N +ELS S + + ++
Sbjct: 1495 RTAQAPEDRSTEPDGSEAEGNQ-VYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTE 1553
Query: 171 WWEGTLNGRTGWFPSNYVREVK 192
WW +NG+ G+ PSNY+R+ +
Sbjct: 1554 WWLAEVNGKKGYVPSNYIRKTE 1575
Score = 38.1 bits (87), Expect = 0.030
Identities = 22/54 (40%), Positives = 29/54 (53%)
Query: 138 VVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 191
VVRA F+F + +EL GD+I V V + W G TG FPS++V V
Sbjct: 6 VVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIV 59
Score = 32.7 bits (73), Expect = 1.3
Identities = 17/53 (32%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 145 FQQTNEDELSFSKGDVIHVTRVEEGGWWEG-TLNGRTGWFPSNYVREVKASEK 196
F D L +GD++ + + GW +G + G G+FPS+ VRE+ S +
Sbjct: 77 FTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQ 129
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,454,696
Number of Sequences: 37866
Number of extensions: 1545000
Number of successful extensions: 6739
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 225
Number of HSP's successfully gapped in prelim test: 363
Number of HSP's that attempted gapping in prelim test: 5574
Number of HSP's gapped (non-prelim): 1245
length of query: 753
length of database: 18,247,518
effective HSP length: 110
effective length of query: 643
effective length of database: 14,082,258
effective search space: 9054891894
effective search space used: 9054891894
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.