Search of human proteins with 166064021

Search of human proteins with 166064021

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|166064021 solute carrier family 22 (organic anion
transporter), member 13 [Homo sapiens]
         (551 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|166064021 solute carrier family 22 (organic anion transporter...  1105   0.0  
gi|157426885 organic cation transporter like 4 [Homo sapiens]         354   1e-97
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       348   7e-96
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   337   1e-92
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   335   5e-92
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          320   2e-87
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          310   2e-84
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   309   5e-84
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   307   2e-83
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          285   8e-77
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]       284   2e-76
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]       283   3e-76
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   274   2e-73
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          273   4e-73
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   272   7e-73
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   266   5e-71
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           264   2e-70
gi|153791484 putative UST1-like organic anion transporter [Homo ...   263   3e-70
gi|42542386 solute carrier family 22 (organic anion/cation trans...   263   4e-70
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           262   7e-70
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       252   7e-67
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          243   3e-64
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        231   1e-60
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   220   2e-57
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          211   1e-54
gi|24308167 SV2 related protein [Homo sapiens]                        140   4e-33
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   135   1e-31
gi|21361834 solute carrier family 22, member 17 isoform a [Homo ...   129   5e-30
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...   121   2e-27
gi|213021148 SVOP-like isoform 1 [Homo sapiens]                       120   4e-27

>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score = 1105 bits (2857), Expect = 0.0
 Identities = 551/551 (100%), Positives = 551/551 (100%)

Query: 1   MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTF 60
           MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTF
Sbjct: 1   MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTF 60

Query: 61  NLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRL 120
           NLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRL
Sbjct: 61  NLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRL 120

Query: 121 PSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGL 180
           PSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGL
Sbjct: 121 PSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGL 180

Query: 181 ATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVL 240
           ATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVL
Sbjct: 181 ATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVL 240

Query: 241 AGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRR 300
           AGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRR
Sbjct: 241 AGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRR 300

Query: 301 KLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGL 360
           KLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGL
Sbjct: 301 KLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGL 360

Query: 361 DVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTM 420
           DVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTM
Sbjct: 361 DVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTM 420

Query: 421 LAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAAL 480
           LAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAAL
Sbjct: 421 LAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAAL 480

Query: 481 PMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETEAKGRTSS 540
           PMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETEAKGRTSS
Sbjct: 481 PMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETEAKGRTSS 540

Query: 541 PGVAFVSSTYF 551
           PGVAFVSSTYF
Sbjct: 541 PGVAFVSSTYF 551


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score =  354 bits (908), Expect = 1e-97
 Identities = 192/525 (36%), Positives = 309/525 (58%), Gaps = 20/525 (3%)

Query: 3   QFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNL 62
           +F  +L  +G+FG FQ +L+ L  + + +S F+ FA  F+   +  +C  +W+     +L
Sbjct: 51  KFANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHL 110

Query: 63  SAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPS 122
           S AEQL L++P    G    C M+ P P N  L  I+    N+T  C  GW YP+ +  S
Sbjct: 111 SKAEQLNLTIPQAPNGSFLTCFMYLPVPWN--LDSIIQFGLNDTDTCQDGWIYPDAKKRS 168

Query: 123 LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLAT 182
           L NEF+LVC  +  KDT Q +FMAGL +G+L+F  + D++GR   IL  LL   + G  T
Sbjct: 169 LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGT 228

Query: 183 AFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAG 242
           AF+ SF LY+  RF ++ +V G + S+++L TEW+    R  A++L  C F++G ++L G
Sbjct: 229 AFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTG 288

Query: 243 LAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKL 302
           +AY   +W+LL + G    +    Y W LPES RWL+ +G++ EA Q++  AASVN++ +
Sbjct: 289 IAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTI 348

Query: 303 SPELMNQL-VPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLD 361
              L+++L +P K     + LD  ++ QL KVTL++ CVWF  S  Y+ LSL++ + G+ 
Sbjct: 349 PSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVS 408

Query: 362 VYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIP---------- 411
           V+   ++   +EVPAR   IF++Q+ GRKWS   TL+   + C++++F+P          
Sbjct: 409 VHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKW 468

Query: 412 -----ADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGIL 466
                 +L  +  ++ ++ + + AA  T+ ++Y+AEL PT+LR TG+GLV + S  G IL
Sbjct: 469 PRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAIL 528

Query: 467 TPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTL 511
           +  + ++ +  + LP+ +   L IVA  L +LLPET  Q L ++L
Sbjct: 529 S--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  348 bits (893), Expect = 7e-96
 Identities = 201/539 (37%), Positives = 291/539 (53%), Gaps = 10/539 (1%)

Query: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLS 63
           F  +L  +G  GRFQ+    LL +   L   + F   F     PHHC             
Sbjct: 3   FTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEASTND 62

Query: 64  AAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPS- 122
           +   L  ++PLD  G PEPC  F  P   A L    S     T+ C  GW Y  +  PS 
Sbjct: 63  SGAWLRATIPLDQLGAPEPCRRFTKPQW-ALLSPNSSIPGAATEGCKDGWVYNRSVFPST 121

Query: 123 LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLAT 182
           +  E++LVC+ + L+D  QSV+MAG+LVG  +FG L DR+G K  ++   L     G AT
Sbjct: 122 IVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAAT 181

Query: 183 AFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAG 242
           A+  SF  Y   RF +    +G+  ++V+L+ EW+    RT A +L   +F+LGQ++LAG
Sbjct: 182 AYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILAG 241

Query: 243 LAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRK- 301
           +AY  R WR LQ   +AP L+ F Y W LPES+RWLL  G+   A+Q +QK A++N RK 
Sbjct: 242 VAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRKE 301

Query: 302 ----LSPELMNQLVPEKTGP---SGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQ 354
               L+ E+M+  +  +      S + LDLFR P +RKVT  +  +WF +S+ YYGL++ 
Sbjct: 302 EGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLAMD 361

Query: 355 VGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADL 414
           +  FGL +YL Q +FG +  PA   +   M   GR+ +    L+L GLM I  +F+P   
Sbjct: 362 LQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVPEGT 421

Query: 415 PVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLG 474
            ++ T  A +GK   A++F   Y+++ EL+PT +RQ GMG   + +R+GG+  PLV  LG
Sbjct: 422 QILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLVTTLG 481

Query: 475 EYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETE 533
           EY   LP + +G+  I+AGL   +L ET    L +T+  +E      S K    EK  E
Sbjct: 482 EYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGSSKKHVEEKSEE 540


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  337 bits (865), Expect = 1e-92
 Identities = 200/548 (36%), Positives = 301/548 (54%), Gaps = 25/548 (4%)

Query: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFL-SPFYFFAHVFMVLDEPHHCAVAWVKNHTFNL 62
           F  +L ++G  GRFQ Q+ + L VL  L    +     F      HHC          NL
Sbjct: 3   FNDLLQQVGGVGRFQ-QIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPP----ADANL 57

Query: 63  SAAEQLVLSVPLDTAGHPEPCLMFRPPPANAS-LQDILSHRFNETQPCDMGWEYPENRLP 121
           S    L + +P D  G PE CL F  P      L    ++    T+PC  GW Y  +  P
Sbjct: 58  SKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFP 117

Query: 122 S-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGL 180
           S +  E++LVC  + L+   QS++M G+L+G ++FG L DR+GR+  ++   L   + G 
Sbjct: 118 STIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGT 177

Query: 181 ATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVL 240
             AF P+F +Y A R     A+AG+S + +TL  EW+    R     L    +SLGQ +L
Sbjct: 178 CAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLL 237

Query: 241 AGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRR 300
           AG+AY   +WR LQ+  +AP    F Y W   ESARW  + GR+D  ++ +Q+ A +N +
Sbjct: 238 AGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGK 297

Query: 301 -----KLSPELMN-QLVPEKTGPSG--NALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLS 352
                KLS E++   L  E T   G  +A++L R P LR + L +  +WF  S  YYGL 
Sbjct: 298 REEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLV 357

Query: 353 LQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPA 412
           + +  FG+ +YL Q+IFGAV++PA+     ++   GR+ +Q+  L+L G+  ++   IP 
Sbjct: 358 MDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQ 417

Query: 413 DLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVIL 472
           D  +V T LAV+GK   AA+F   ++Y+ EL+PT++RQTGMG+    +R+G I++PLV +
Sbjct: 418 DQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSM 477

Query: 473 LGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDL---------ELGPHPRSP 523
             E + ++P+ IYG++P+ A  +  LLPET GQ L DT+QDL         E G +PR  
Sbjct: 478 TAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKG 537

Query: 524 KSVPSEKE 531
           K    ++E
Sbjct: 538 KQTRQQQE 545


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  335 bits (860), Expect = 5e-92
 Identities = 195/523 (37%), Positives = 293/523 (56%), Gaps = 16/523 (3%)

Query: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFL-SPFYFFAHVFMVLDEPHHCAVAWVKNHTFNL 62
           F  +L ++G  GRFQ Q+ + L VL  L    +     F      HHC          NL
Sbjct: 3   FNDLLQQVGGVGRFQ-QIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPP----ADANL 57

Query: 63  SAAEQLVLSVPLDTAGHPEPCLMFRPPPANAS-LQDILSHRFNETQPCDMGWEYPENRLP 121
           S    L + +P D  G PE CL F  P      L    ++    T+PC  GW Y  +  P
Sbjct: 58  SKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFP 117

Query: 122 S-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGL 180
           S +  E++LVC  + L+   QS++M G+L+G ++FG L DR+GR+  ++   L   + G 
Sbjct: 118 STIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGT 177

Query: 181 ATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVL 240
             AF P+F +Y A R     A+AG+S + +TL  EW+    R     L    +SLGQ +L
Sbjct: 178 CAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLL 237

Query: 241 AGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRR 300
           AG+AY   +WR LQ+  +AP    F Y W   ESARW  + GR+D  ++ +Q+ A +N +
Sbjct: 238 AGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGK 297

Query: 301 -----KLSPELMN-QLVPEKTGPSG--NALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLS 352
                KLS E++   L  E T   G  +A++L R P LR + L +  +WF  S  YYGL 
Sbjct: 298 REEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLV 357

Query: 353 LQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPA 412
           + +  FG+ +YL Q+IFGAV++PA+     ++   GR+ +Q+  L+L G+  ++   IP 
Sbjct: 358 MDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQ 417

Query: 413 DLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVIL 472
           D  +V T LAV+GK   AA+F   ++Y+ EL+PT++RQTGMG+    +R+G I++PLV +
Sbjct: 418 DQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSM 477

Query: 473 LGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515
             E + ++P+ IYG++P+ A  +  LLPET GQ L DT+QDLE
Sbjct: 478 TAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLE 520


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  320 bits (821), Expect = 2e-87
 Identities = 190/548 (34%), Positives = 292/548 (53%), Gaps = 37/548 (6%)

Query: 4   FVQVLAEIGDFGRFQ-IQLLIL-LCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFN 61
           F ++L  +G  G FQ + + IL L +LN  +  +    +F      HHC          N
Sbjct: 3   FSEILDRVGSMGHFQFLHVAILGLPILNMAN--HNLLQIFTAATPVHHC------RPPHN 54

Query: 62  LSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQ----PCDMGWEYPE 117
            S    ++   P+   G PE CL F  PP NASL        N+TQ    PC  GW Y  
Sbjct: 55  ASTGPWVL---PMGPNGKPERCLRFVHPP-NASLP-------NDTQRAMEPCLDGWVYNS 103

Query: 118 NRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTL 177
            +  S+  E++LVC+   LK+  QS+FMAG+L+G L+ G L DR GR+  +    LL   
Sbjct: 104 TK-DSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAA 162

Query: 178 IGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRT-QAVVLAQCNFSLG 236
            G   AF P+F +YM  RF     ++G++ S V L  EWV    R   +  L  C ++ G
Sbjct: 163 SGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC-YTFG 221

Query: 237 QMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAAS 296
           Q +L GLAY    WR LQ+T + P  + F   W  PES RWL+  G+  +A++++++ A 
Sbjct: 222 QFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAV 281

Query: 297 VNRRKLSPELMN--------QLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGY 348
            N +K   E ++        Q           A DLFR P LR++T  +   WF     Y
Sbjct: 282 FNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAY 341

Query: 349 YGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIII 408
           Y L++ V +FG+++Y+ Q+IFG V+VPA+  +I  +   GR  +Q   L+L G   + + 
Sbjct: 342 YSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALT 401

Query: 409 FIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTP 468
           F+P DL  V T+LAV GK   +++F+  ++Y++EL+PT++RQTGMG+  +++R+G +++P
Sbjct: 402 FVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSP 461

Query: 469 LVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE-LGPHPRSPKSVP 527
           LV + GE    +P +IYG   ++ G     LPET  Q L +T++DLE      + PK  P
Sbjct: 462 LVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEP 521

Query: 528 SEKETEAK 535
             ++   +
Sbjct: 522 EVEKASQR 529


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  310 bits (795), Expect = 2e-84
 Identities = 186/530 (35%), Positives = 283/530 (53%), Gaps = 19/530 (3%)

Query: 4   FVQVLAEIGDFGRFQI-QLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTF-- 60
           F ++L  +G  GRFQ+ Q + L+  + +L       + F      H C    + N T   
Sbjct: 3   FSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLEN-FSAAVPSHRCWAPLLDNSTAQA 61

Query: 61  ----NLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNE--TQPCDMGWE 114
               +LS    L +S+P      P  C  FR P       +  +  ++E  T+PC  GW 
Sbjct: 62  SILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWV 121

Query: 115 YPENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLL 173
           Y  +   S +  ++NLVCD   LK   QS+++AG+LVG    GP  DR GR+  +    L
Sbjct: 122 YDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYL 181

Query: 174 LFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNF 233
              ++G A AF P+F +Y   RF +A AVAG+  +  TLL EW     R   + L    F
Sbjct: 182 QMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGF 241

Query: 234 SLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQK 293
           S G  + A +AYG R+W LLQ+  + P  L F Y W L ESARWLLT GR+D  +Q + +
Sbjct: 242 SFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWR 301

Query: 294 AASVNRR-----KLSPELMNQLVPEKTG---PSGNALDLFRHPQLRKVTLIIFCVWFVDS 345
            A++N +      L+PE++   + E+     P  +   L R P LR  T I    WF   
Sbjct: 302 VAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFG 361

Query: 346 LGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCI 405
             ++GL+L +   G +++L Q+  G V++PA+  ++ ++   GR+ +   +L+L GL  +
Sbjct: 362 FTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCIL 421

Query: 406 IIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGI 465
               +P ++  + + LAV+G     AAFT   +YS+ELFPT+LR T +GL  + +R G I
Sbjct: 422 ANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAI 481

Query: 466 LTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515
           L PLV LLG +   LP+L+YG++P+++GL   LLPET    L DT+QD++
Sbjct: 482 LGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQ 531


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  309 bits (791), Expect = 5e-84
 Identities = 190/533 (35%), Positives = 284/533 (53%), Gaps = 16/533 (3%)

Query: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLS 63
           F ++L ++G FG FQ++ + LL +   L P +F   +F+     H CA+     +  +  
Sbjct: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQD 62

Query: 64  AAEQLVLSVPLDTAGHPEPCLMFRPPPA--NASLQDILSHRFN-----ETQPCDMGWEYP 116
               L   +P +  G    CL F  P A  N +L +    R        T PC  GWEY 
Sbjct: 63  V--WLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120

Query: 117 ENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLF 175
            +   S +  E++LVC++K L     + F AG+LVG + FG L DR GR+  +L   +  
Sbjct: 121 HSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVST 180

Query: 176 TLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSL 235
            ++GLA+A   S+ ++   R    +A+AG +   + L  EW+    RT A VL+   ++ 
Sbjct: 181 LVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTG 240

Query: 236 GQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAA 295
           G M+LA + Y  R+WR L +  T P        W +PESARWLLT+G + EA + +   A
Sbjct: 241 GVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCA 300

Query: 296 SVNRRKLSPELMNQLVPEKTGPSGNA------LDLFRHPQLRKVTLIIFCVWFVDSLGYY 349
            +N R +  +  +Q    K             LDLFR P+LR ++L    VWF  +  YY
Sbjct: 301 RLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYY 360

Query: 350 GLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIF 409
           GLSL V   GL+VY TQL+FGAVE+P++      ++  GR+ +Q GTL+   L     + 
Sbjct: 361 GLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLL 420

Query: 410 IPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPL 469
           + +D+    T+LAV+GK  + AAFT +Y++++EL+PT+LRQTGMGL  +  R+GG L PL
Sbjct: 421 VSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPL 480

Query: 470 VILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRS 522
             LL     +LP L YG + ++A     LLPET    L +T+QD+E    P S
Sbjct: 481 AALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTS 533


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  307 bits (786), Expect = 2e-83
 Identities = 189/535 (35%), Positives = 285/535 (53%), Gaps = 18/535 (3%)

Query: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLS 63
           F ++L ++G FG FQ++ + LL +   L P +F   +F+     H CA+     +  +  
Sbjct: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQD 62

Query: 64  AAEQLVLSVPLDTAGHPEPCLMFRPPPA--NASLQDILSHRFN-----ETQPCDMGWEYP 116
               L   +P +  G    CL F  P A  N +L +    R        T PC  GWEY 
Sbjct: 63  V--WLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120

Query: 117 ENRLPSL---KNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLL 173
            +   S    +++++LVC++K L     + F AG+LVG + FG L DR GR+  +L   +
Sbjct: 121 HSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV 180

Query: 174 LFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNF 233
              ++GLA+A   S+ ++   R    +A+AG +   + L  EW+    RT A VL+   +
Sbjct: 181 STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW 240

Query: 234 SLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQK 293
           + G M+LA + Y  R+WR L +  T P        W +PESARWLLT+G + EA + +  
Sbjct: 241 TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH 300

Query: 294 AASVNRRKLSPELMNQLVPEKTGPSGNA------LDLFRHPQLRKVTLIIFCVWFVDSLG 347
            A +N R +  +  +Q    K             LDLFR P+LR ++L    VWF  +  
Sbjct: 301 CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFS 360

Query: 348 YYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIII 407
           YYGLSL V   GL+VY TQL+FGAVE+P++      ++  GR+ +Q GTL+   L     
Sbjct: 361 YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR 420

Query: 408 IFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILT 467
           + + +D+    T+LAV+GK  + AAFT +Y++++EL+PT+LRQTGMGL  +  R+GG L 
Sbjct: 421 LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA 480

Query: 468 PLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRS 522
           PL  LL     +LP L YG + ++A     LLPET    L +T+QD+E    P S
Sbjct: 481 PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTS 535


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  285 bits (729), Expect = 8e-77
 Identities = 177/547 (32%), Positives = 279/547 (51%), Gaps = 26/547 (4%)

Query: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTF--- 60
           F ++L + G  G FQ   ++   +   + P       F      H C    + N +    
Sbjct: 3   FSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVST 62

Query: 61  NLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNE--TQPCDMGWEYPEN 118
           N++    L +S+P      P  C  FR P       +  +  ++E  T+PC  GW Y  +
Sbjct: 63  NMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRS 122

Query: 119 RLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTL 177
              S +  +++LVC  + LK  +QS+FM+G+LVG+ ++G L  R GRK  +    L   +
Sbjct: 123 VFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAV 182

Query: 178 IGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQ 237
            G +T F P+F +Y  LRF  A  +AG+  S++TL+ EW   S R   + +  C FS GQ
Sbjct: 183 AGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQ 242

Query: 238 MVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASV 297
             L GLA+  R+WR LQ+  + P   +    W LPESARWL+ +G+ D+A+Q ++K A +
Sbjct: 243 AALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARI 302

Query: 298 NRRK----LSPELMNQLVPEKTGPS---GNALDLFRHPQLRKVTLIIFCVWFVDSLGYYG 350
           N  K    L+ E++   V E+   +    + LDLF  P LR  +  +  V F   + YYG
Sbjct: 303 NGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYG 362

Query: 351 LSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFI 410
           L   +   G D++L Q +FGAV+   R ++  ++   GR+  Q G+  + GL  +  + +
Sbjct: 363 LVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLV 422

Query: 411 PADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLV 470
           P DL  +  + AV+GK     + T   +Y AELFPT +R T  G++    R+G ++ PL+
Sbjct: 423 PQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLI 482

Query: 471 ILLGEYHAALPMLIYGSLPIVAGLLCT-LLPETHGQGLKDTLQDLELGPHPRSPKSVPSE 529
           ++  +    LP L+YG + I + L+    LPET G  L DT+QDLE            S+
Sbjct: 483 LMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLE------------SQ 530

Query: 530 KETEAKG 536
           K T A+G
Sbjct: 531 KSTAAQG 537


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score =  284 bits (726), Expect = 2e-76
 Identities = 175/529 (33%), Positives = 276/529 (52%), Gaps = 17/529 (3%)

Query: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFN-- 61
           F  +L ++G  GRFQI L+   C+ N L         F      H C V  + N T +  
Sbjct: 3   FDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDN 62

Query: 62  ----LSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNE--TQPCDMGWEY 115
               LS  + L +S+PLD+   P+ C  F  P       +      NE  T+PC  GW Y
Sbjct: 63  DTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGWVY 122

Query: 116 PENR-LPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLL 174
             +  L ++  E++LVC+ + LK   QS+FMAG L+G L++G L DR+GRK       L 
Sbjct: 123 DRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQ 182

Query: 175 FTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFS 234
             +     AF P+F +Y  LRF    +   +  +   L  EW  P  R+  +++  C++S
Sbjct: 183 LAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYS 242

Query: 235 LGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKA 294
           +GQM+L GLA+  ++W +LQ+T + P ++LF   W + ESARWL+   ++DE ++ +++ 
Sbjct: 243 VGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRV 302

Query: 295 ASVNRRK-----LSPELMNQLVPEKTGP---SGNALDLFRHPQLRKVTLIIFCVWFVDSL 346
           A +N +K     L+ EL+   + ++        +   LFR P+LR     +  V F  ++
Sbjct: 303 AHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAITV 362

Query: 347 GYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCII 406
            +YGL L +   G +V L Q++ GAV   ARC S+  +   GR+ SQ+      GL  ++
Sbjct: 363 PFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFILV 422

Query: 407 IIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGIL 466
             F+P ++ ++  +LA +G  + +AA   + V+  EL PTILR T  G+  +  R G  L
Sbjct: 423 NTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGAAL 482

Query: 467 TPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515
            PL++ L  Y   LP + YG  PI+A  +  LLPET    L +T+QD+E
Sbjct: 483 APLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVE 531


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score =  283 bits (724), Expect = 3e-76
 Identities = 173/530 (32%), Positives = 278/530 (52%), Gaps = 19/530 (3%)

Query: 4   FVQVLAEIGDFGRFQ-IQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFN- 61
           F ++L+++G  GRFQ + L+ +L  L  L P     + F      H C V  + N+T + 
Sbjct: 3   FEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLEN-FAAAIPGHRCWVHMLDNNTGSG 61

Query: 62  -----LSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNE--TQPCDMGWE 114
                LS    L +S+PLD+   PE C  F  P       +   H  +E  T+PC  GW 
Sbjct: 62  NETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGWV 121

Query: 115 YPENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLL 173
           Y ++  PS +  +++LVCD + LK   Q + + G+LVG ++ G + DR GR+  +   LL
Sbjct: 122 YDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCLL 181

Query: 174 LFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNF 233
              +     AF P+F +Y  LRF    +   +  +N   +TEW+ P+ +   V+L+    
Sbjct: 182 QLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGAL 241

Query: 234 SLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQK 293
           S+GQ++L GLAY FR+W+ L +  + P  + F     L ESARWL+   ++DE ++ ++K
Sbjct: 242 SIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRK 301

Query: 294 AASVNRRKLSPELMNQLVPEKT--------GPSGNALDLFRHPQLRKVTLIIFCVWFVDS 345
            A  N  K + E +N  V   T               DLFR+P +RK   I+  + F ++
Sbjct: 302 VARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANT 361

Query: 346 LGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCI 405
           + +YG  + +   G +++L Q+++GAV +  RC ++  +   GR+ SQ+  + L GL  +
Sbjct: 362 IPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSIL 421

Query: 406 IIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGI 465
              F+P ++  +   LA +G   +AA F+   V+  EL PT+LR    G+    SRIG  
Sbjct: 422 ANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGAA 481

Query: 466 LTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515
           L PL++ L  +   LP +IYG  PI+ GL+  LLPET    L DT++D+E
Sbjct: 482 LAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVE 531


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  274 bits (700), Expect = 2e-73
 Identities = 182/548 (33%), Positives = 270/548 (49%), Gaps = 69/548 (12%)

Query: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFL-SPFYFFAHVFMVLDEPHHCAVAWVKNHTFNL 62
           F  +L ++G  GRFQ Q+ + L VL  L    +     F      HHC          NL
Sbjct: 3   FNDLLQQVGGVGRFQ-QIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPP----ADANL 57

Query: 63  SAAEQLVLSVPLDTAGHPEPCLMFRPPPANAS-LQDILSHRFNETQPCDMGWEYPENRLP 121
           S    L + +P D  G PE CL F  P      L    ++    T+PC  GW Y  +  P
Sbjct: 58  SKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFP 117

Query: 122 S-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGL 180
           S +  E++LVC  + L+   QS++M G+L+G ++FG L DR+GR+  ++   L   + G 
Sbjct: 118 STIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGT 177

Query: 181 ATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVL 240
             AF P+F +Y A R     A+AG+S + +TL  EW+    R     L    +SLGQ +L
Sbjct: 178 CAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLL 237

Query: 241 AGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRR 300
           AG+AY   +WR LQ+  +AP    F Y W   ESARW  + GR+D  ++ +Q+ A +N +
Sbjct: 238 AGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGK 297

Query: 301 -----KLSPELMN-QLVPEKTGPSG--NALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLS 352
                KLS E++   L  E T   G  +A++L R P LR + L +  +WF  S  YYGL 
Sbjct: 298 REEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLV 357

Query: 353 LQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPA 412
           + +  FG+ +YL Q+IFGAV++PA+     ++   GR+ +Q+  L+L G+  ++   IP 
Sbjct: 358 MDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQ 417

Query: 413 DLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVIL 472
           D  +V T LAV+GK   AA+F   ++Y+ EL+PT++R                       
Sbjct: 418 DQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR----------------------- 454

Query: 473 LGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDL---------ELGPHPRSP 523
                                 +  LLPET GQ L DT+QDL         E G +PR  
Sbjct: 455 ---------------------AVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKG 493

Query: 524 KSVPSEKE 531
           K    ++E
Sbjct: 494 KQTRQQQE 501


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  273 bits (697), Expect = 4e-73
 Identities = 173/551 (31%), Positives = 271/551 (49%), Gaps = 24/551 (4%)

Query: 1   MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCA---VAWVKN 57
           M  F + L  +G+FGRFQ ++ +LLC+      F F   VF+     H+      A    
Sbjct: 1   MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALA 60

Query: 58  HTFNLSAAEQLVLSVPLDTAGHPEP------CLMFRPPPAN--ASLQDILS--------- 100
                S  E+   + P      PEP      C  +    AN  AS    LS         
Sbjct: 61  ERCGWSPEEEWNRTAPASRG--PEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFP 118

Query: 101 HRFNETQPCDMGWEYPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCD 160
           +R     PC  GW Y +    ++ +EF+LVC    + D TQ++   G L G    G   D
Sbjct: 119 NRSAPLVPCRGGWRYAQAH-STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAAD 177

Query: 161 RIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPS 220
           R GR    L   L   + G+  AF P+F +++  RF       G   +   ++TE VG  
Sbjct: 178 RYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSK 237

Query: 221 WRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLT 280
            R    ++ Q  F+LG ++L G+AY   NW+ +Q+  T P  L   Y+W +PES RWL+T
Sbjct: 238 QRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLIT 297

Query: 281 RGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCV 340
           R + D+A+Q++++ A  N + LS       V ++   + + LDL R PQ+RK TLI+   
Sbjct: 298 RKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFA 357

Query: 341 WFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLG 400
           WF  ++ Y GL +++G  G ++Y+   I G VE+P     +  ++R GR+     + ++ 
Sbjct: 358 WFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVA 417

Query: 401 GLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFS 460
           G+ C++  F+P  +  + T +A +G++    AF I Y+ ++EL+PT LR  G+ L     
Sbjct: 418 GVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLC 477

Query: 461 RIGGILTP-LVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPH 519
             GGI+ P L+  L      LP++I+G L  + G L  LLPET G  L +T+ D+E    
Sbjct: 478 DFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGS 537

Query: 520 PRSPKSVPSEK 530
           P S K   ++K
Sbjct: 538 PHSCKCGRNKK 548


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  272 bits (695), Expect = 7e-73
 Identities = 177/523 (33%), Positives = 262/523 (50%), Gaps = 60/523 (11%)

Query: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFL-SPFYFFAHVFMVLDEPHHCAVAWVKNHTFNL 62
           F  +L ++G  GRFQ Q+ + L VL  L    +     F      HHC          NL
Sbjct: 3   FNDLLQQVGGVGRFQ-QIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPP----ADANL 57

Query: 63  SAAEQLVLSVPLDTAGHPEPCLMFRPPPANAS-LQDILSHRFNETQPCDMGWEYPENRLP 121
           S    L + +P D  G PE CL F  P      L    ++    T+PC  GW Y  +  P
Sbjct: 58  SKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFP 117

Query: 122 S-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGL 180
           S +  E++LVC  + L+   QS++M G+L+G ++FG L DR+GR+  ++   L   + G 
Sbjct: 118 STIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGT 177

Query: 181 ATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVL 240
             AF P+F +Y A R     A+AG+S + +TL  EW+    R     L    +SLGQ +L
Sbjct: 178 CAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLL 237

Query: 241 AGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRR 300
           AG+AY   +WR LQ+  +AP    F Y W   ESARW  + GR+D  ++ +Q+ A +N +
Sbjct: 238 AGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGK 297

Query: 301 -----KLSPELMN-QLVPEKTGPSG--NALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLS 352
                KLS E++   L  E T   G  +A++L R P LR + L +  +WF  S  YYGL 
Sbjct: 298 REEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLV 357

Query: 353 LQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPA 412
           + +  FG+ +YL Q+IFGAV++PA+     ++   GR+ +Q+  L+L G+  ++   IP 
Sbjct: 358 MDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQ 417

Query: 413 DLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVIL 472
           D  +V T LAV+GK   AA+F   ++Y+ EL+PT++R                       
Sbjct: 418 DQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR----------------------- 454

Query: 473 LGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515
                                 +  LLPET GQ L DT+QDLE
Sbjct: 455 ---------------------AVTVLLPETLGQPLPDTVQDLE 476


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  266 bits (679), Expect = 5e-71
 Identities = 186/554 (33%), Positives = 276/554 (49%), Gaps = 28/554 (5%)

Query: 7   VLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVK--NHTFNLSA 64
           +L ++G+ G FQ Q  ++LC+L+          VF+     HHC    V   +     S 
Sbjct: 7   ILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWSP 66

Query: 65  AEQLVLSVP-LDTAGHP--EPCLMFRPP---PANASLQDILSHRFNETQ----PCDMGWE 114
           AE+L  +VP L  AG      C  +       A + +  + S   N +     PC  GW 
Sbjct: 67  AEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWV 126

Query: 115 YPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLL 174
           Y +    S+  EFNLVC      D  QS   AG L G+L  G   DR GRK  +L  +L+
Sbjct: 127 Y-DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLV 185

Query: 175 FTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFS 234
             + G+  AF P++   +  R        G   +  TL+TE+VG   R    ++ Q  F+
Sbjct: 186 NAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFT 245

Query: 235 LGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKA 294
           +G + L GLAY   +WR LQ+  + P  L   Y+W +PES RWLL++ R  EAI+++   
Sbjct: 246 VGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHI 305

Query: 295 ASVNRRKLSPELMNQL-----VPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYY 349
           A  N  KL P  +  L     V EK  PS    DLFR P+LRK T I+  +WF DS+ Y 
Sbjct: 306 AQKN-GKLPPADLKMLSLEEDVTEKLSPS--FADLFRTPRLRKRTFILMYLWFTDSVLYQ 362

Query: 350 GLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIF 409
           GL L +G    ++YL  L    VE+P    ++  + R GR +    + +L G  C+++IF
Sbjct: 363 GLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIF 422

Query: 410 IPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPL 469
           I  DL  +  ++  VG+M    A  +  + +AEL+PT +R  G+ +      IGGI+TP 
Sbjct: 423 ISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPF 482

Query: 470 VIL-LGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE-LGPHPRSPKSVP 527
           ++  L E   ALP++++  L ++A  +  LLPET G  L +T++D E LG      K+ P
Sbjct: 483 IVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLG-----RKAKP 537

Query: 528 SEKETEAKGRTSSP 541
            E     K +TS P
Sbjct: 538 KENTIYLKVQTSEP 551


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  264 bits (674), Expect = 2e-70
 Identities = 175/534 (32%), Positives = 268/534 (50%), Gaps = 30/534 (5%)

Query: 1   MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAV-------- 52
           M  + +V A +G++G FQ  +  LL      + F   + VF++    H C V        
Sbjct: 1   MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS 60

Query: 53  AWVKNHTFNLSAAEQLVLSVPLDTAGHPEPCLMFRPPP-ANASLQDILSHRFN-----ET 106
           AW +NHT  L            D    P  C  +R    AN S   +   R       E 
Sbjct: 61  AW-RNHTVPLRLR---------DGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQ 110

Query: 107 QPCDMGWEYPEN-RLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRK 165
           + C  GWE+ ++  L ++  E+NLVC+       T S+F  G+L+G+ + G L DR GRK
Sbjct: 111 ESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRK 170

Query: 166 ATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQA 225
             +   + + T       F  +FE+++ L   V         +   L TE +G S R   
Sbjct: 171 NVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIF 230

Query: 226 VVLAQCNF-SLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRM 284
             L  C F + G MVL   AY  R+WR+L +  T PG+L    +W +PES RWL+++GR 
Sbjct: 231 STLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRF 290

Query: 285 DEAIQLIQKAASVNRRKLSPELMN----QLVPEKTGPSGNALDLFRHPQLRKVTLIIFCV 340
           +EA  +I+KAA  N   +   + +    Q +  K   S N LDL R   +R VT++   +
Sbjct: 291 EEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIML 350

Query: 341 WFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLG 400
           W   S+GY+GLSL   +   D+++   +   VEVPA   +  ++Q   R++S    L LG
Sbjct: 351 WMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLG 410

Query: 401 GLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFS 460
           G + + +  +P DL  + T+L +VGK    AAF++ YVY+AEL+PT++R  G+G+    S
Sbjct: 411 GSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTAS 470

Query: 461 RIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDL 514
           R+G IL+P  + LG Y   LP ++ GSL I+  +L   LPE+ G  L DT+  +
Sbjct: 471 RLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQM 524


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  263 bits (672), Expect = 3e-70
 Identities = 163/532 (30%), Positives = 267/532 (50%), Gaps = 23/532 (4%)

Query: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTF--- 60
           F  +L ++G  GRFQI  ++ L + N +         F      H C V  + N T    
Sbjct: 3   FQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDN 62

Query: 61  ---NLSAAEQLVLSVPLDTAGHPEPCLMFRPPP-----ANASLQDILSHRFNETQPCDMG 112
               LS    L +S+P D+   PE C  F  P       N +  +       +T+PC  G
Sbjct: 63  DPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEP---DTEPCVDG 119

Query: 113 WEYPENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQ 171
           W Y ++  PS +  +++LVC+ + L    + +FMAG++VG  ++G L DR GRK  +   
Sbjct: 120 WVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWS 179

Query: 172 LLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQC 231
            L   ++G   AF P+  +Y +LRF    A   +  + V L+ EW+   +   A+ L  C
Sbjct: 180 YLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLC 239

Query: 232 NFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLI 291
             S+G + L  LA+  R+  +LQ+  +AP  + F +   L ESARWL+   + +E ++ +
Sbjct: 240 AASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKEL 299

Query: 292 QKAASVNRRKLSPELMNQLVPEKT--------GPSGNALDLFRHPQLRKVTLIIFCVWFV 343
           +KAA  N  K + +++   V + T            +  +L R P + K    +  V F 
Sbjct: 300 RKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFA 359

Query: 344 DSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLM 403
            ++ ++GL+L +   G +V+L Q +FGAV + A C + + +    R+ SQ+  + L    
Sbjct: 360 STIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATC 419

Query: 404 CIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIG 463
            + IIF+P ++  +  +LA +G  A +   T S     EL P+I+R    G+ G F+ IG
Sbjct: 420 LLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIG 479

Query: 464 GILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515
           G L  L+++L  Y   LP +IYG   I++GL+  LLPET  Q L D++QD+E
Sbjct: 480 GALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVE 531


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score =  263 bits (671), Expect = 4e-70
 Identities = 170/545 (31%), Positives = 270/545 (49%), Gaps = 29/545 (5%)

Query: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFN-- 61
           F  +L   GD  RFQI   + L +    +  +F    F      H C V  + N T +  
Sbjct: 3   FQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDN 62

Query: 62  ----LSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNET-----QPCDMG 112
               LS    L +S+PLD+   PE C  F  P         L+  F  T     +PC  G
Sbjct: 63  DTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLH---LNGTFPNTSDADMEPCVDG 119

Query: 113 WEYPENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQ 171
           W Y      S +  E++LVCD + L    + VFMAG++VG ++ G L DR GR+  +   
Sbjct: 120 WVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWC 179

Query: 172 LLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQC 231
            L   ++G   A  P+F +Y +LRF    A   L  + + L+ EW    ++   + L  C
Sbjct: 180 YLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMC 239

Query: 232 NFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLI 291
              +  M LAGLA+  R+W +LQ+  + P  ++F     L ESARWL+   + +E ++ +
Sbjct: 240 PSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299

Query: 292 QKAASVNRRK-----LSPELMNQLVP------EKTGPSGNALDLFRHPQLRKVTLIIFCV 340
           +KAA  +  K     L+ E++   +       +K  PS    ++   P + K   ++   
Sbjct: 300 RKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPS--LCEMLHMPNICKRISLLSFT 357

Query: 341 WFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLG 400
            F + + Y+GL+L V   G +V+L Q +FGAV + A C + + ++   R+ SQ+  + L 
Sbjct: 358 RFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLL 417

Query: 401 GLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFS 460
            +  + IIF+P ++  +  +LA +G  A+A A T+++ +  E+ PTI+R   MG+   F+
Sbjct: 418 AICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFA 477

Query: 461 RIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQD-LELGPH 519
            I G L PL+++L  Y   LP +IYG  P ++G    LLPET  + L DT+QD       
Sbjct: 478 NIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKD 537

Query: 520 PRSPK 524
           PR PK
Sbjct: 538 PREPK 542


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  262 bits (669), Expect = 7e-70
 Identities = 171/533 (32%), Positives = 263/533 (49%), Gaps = 16/533 (3%)

Query: 7   VLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNL--SA 64
           VL   G+F  FQ Q+  LL +L+      +   VF+     H C    V   +     S 
Sbjct: 8   VLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSP 67

Query: 65  AEQLVLSVP-LDTAGHPEP--CLMFRPPPANAS---LQDILSHRFNETQ----PCDMGWE 114
           AE+L  +VP    AG   P  C  +      ++   +  + S   N ++    PC  GW 
Sbjct: 68  AEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWV 127

Query: 115 YPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLL 174
           Y E    S+  EFNLVC    + D  QS    G  +G++  G + DR GRK  +L  +L+
Sbjct: 128 Y-ETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLI 186

Query: 175 FTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFS 234
               G+  A  P++   +  R                L+TE+VG  +R    +  Q  ++
Sbjct: 187 NAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYT 246

Query: 235 LGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKA 294
           +G +VLAG+AY   +WR LQ T   P      Y+W +PES RWL+++ +  EA+++I+  
Sbjct: 247 VGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHI 306

Query: 295 ASVNRRKLSPELMNQLVPEKTGPSGNA--LDLFRHPQLRKVTLIIFCVWFVDSLGYYGLS 352
           A  N + L   L    + E+TG   N   LDL R PQ+RK T+I+   WF  S+ Y GL 
Sbjct: 307 AKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLI 366

Query: 353 LQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPA 412
           + +G  G ++YL       VE PA    I  + R GR++    + ++ G  C+  +FIP 
Sbjct: 367 MHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPG 426

Query: 413 DLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTP-LVI 471
           DL  +  +++ +G+M    A+ I  + +AEL+PT +R  G+ +      IGGI+TP LV 
Sbjct: 427 DLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVY 486

Query: 472 LLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPK 524
            L      LP++++G L +VAG L  LLPET G+ L +T+++ E    PR  K
Sbjct: 487 RLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNK 539


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  252 bits (643), Expect = 7e-67
 Identities = 144/408 (35%), Positives = 221/408 (54%), Gaps = 8/408 (1%)

Query: 122 SLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLA 181
           S+ +E+ L+ +R +      S F +G+ VG + FG L DR GRK   L    L  L  +A
Sbjct: 96  SIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIA 155

Query: 182 TAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLA 241
             F PS+E +   RF V     G+S     LL E VG ++   A  +    F++G    A
Sbjct: 156 NGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYA 215

Query: 242 GLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRK 301
            L Y  R+WR L I     G ++F     +PES RWL ++GR+ EA + +   A  NR+ 
Sbjct: 216 LLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKL 275

Query: 302 LSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLD 361
                +          +G+ LDLFR+  L   TLI+  +WFV SL YYGL+L  GD G  
Sbjct: 276 KCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGS 335

Query: 362 VYLTQLIFGAVEVPARCSSIFMMQR--FGRKWSQLGTLVLGGLMCIIIIFIP--ADLPVV 417
           +Y    + G +E+P+    I+++ +  FGRK +    L LGGL C+I++F+P   D  V 
Sbjct: 336 IYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVF 395

Query: 418 VTM----LAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILL 473
             +    L+++GK+  +AAF I Y+Y++EL+PT++R  G+G   +FSR+GGI+ P +  L
Sbjct: 396 AVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSL 455

Query: 474 GEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPR 521
                +LP +++G+  + +GLL  LLPET    L +T  DL++  + R
Sbjct: 456 KYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRR 503


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  243 bits (621), Expect = 3e-64
 Identities = 172/550 (31%), Positives = 272/550 (49%), Gaps = 26/550 (4%)

Query: 1   MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTF 60
           M  + +V+A +G++G FQ  +  LL      + F   + VF+     H C V        
Sbjct: 1   MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP----DAA 56

Query: 61  NLSAAEQLVLSVPL---DTAGHPEPCLMFRPPP-ANASLQDILSHRFN-----ETQPCDM 111
           NLS+A +   SVPL   D    P  C  +R    AN S   +   R       E + C  
Sbjct: 57  NLSSAWRNN-SVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLD 115

Query: 112 GWEYPEN-RLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILA 170
           GWE+ ++  L ++  E+NLVC+       T S+F  G+L+G+ + G L DR GRK  + A
Sbjct: 116 GWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFA 175

Query: 171 QLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQ 230
            + + T       F  S+E++  L   V             L TE +G S R     L  
Sbjct: 176 TMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGV 235

Query: 231 CNF-SLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQ 289
           C F ++G M+L   AY  R+WR+L +  T PG+L    +W +PES RWL+++ R  EA  
Sbjct: 236 CTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAED 295

Query: 290 LIQKAASVNRRKL------SPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFV 343
           +IQKAA +N   +      S E +N L  +K       LDLFR   +  +T++   +W +
Sbjct: 296 IIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAF----ILDLFRTRNIAIMTIMSLLLWML 351

Query: 344 DSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLM 403
            S+GY+ LSL   +   D YL   +   +E+PA  ++  +++   R++     L  GG +
Sbjct: 352 TSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGV 411

Query: 404 CIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIG 463
            + I  +P D   +   L ++GK    +AF++ YV++AEL+PT++R   +G+    SR+G
Sbjct: 412 LLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVG 471

Query: 464 GILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSP 523
            I+ P  + LG Y+  LP ++ GSL ++ G+L    PE+ G  L +TL+ ++     RS 
Sbjct: 472 SIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSG 531

Query: 524 KSVPSEKETE 533
           K      ETE
Sbjct: 532 KKTRDSMETE 541


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  231 bits (590), Expect = 1e-60
 Identities = 162/534 (30%), Positives = 252/534 (47%), Gaps = 25/534 (4%)

Query: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCA----VAWVKNHT 59
           F  +   +G FGRFQ  L  +    N     ++ A VFM +   H C     V+ V  H 
Sbjct: 6   FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65

Query: 60  FN----------LSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPC 109
            +          LS+ ++  ++V L      E     R    N S          +  PC
Sbjct: 66  HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPC 125

Query: 110 DMGWEYPENRLPSLK-NEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATI 168
             G+ Y +N   S    ++NLVCDRK L    Q +FM G+L+G++ FG   DR+GR+  +
Sbjct: 126 VDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVL 185

Query: 169 LAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVL 228
            A      L G+A AF   +  +MA RF +A   +G        + E++G   RT A V 
Sbjct: 186 WATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVH 245

Query: 229 AQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAI 288
               F++G +++A   Y  R W L Q+  +   +      W LPE+  WLL+ GR +EA 
Sbjct: 246 LHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQ 305

Query: 289 QLIQKAASVNRRKLSPELMNQLVPEKTGPSGNALD---------LFRHPQLRKVTLIIFC 339
           +++   A  NR   S +L   L  +  GP  N+           LF +  + K TL ++ 
Sbjct: 306 KIVDIMAKWNRAS-SCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWL 364

Query: 340 VWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVL 399
           +WF  SLG+Y  SL   + G + YL   + G VE+PA       M + GR+     +L  
Sbjct: 365 IWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFC 424

Query: 400 GGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIF 459
             L C +++ IP    ++  + A+VGK A  AAF + Y+Y+AEL+PTI+R   +G   + 
Sbjct: 425 SALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMV 484

Query: 460 SRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQD 513
            R+  IL P  + L      +P L  G++ +++G+L   LPET G+ L  T ++
Sbjct: 485 CRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEE 538


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  220 bits (561), Expect = 2e-57
 Identities = 153/463 (33%), Positives = 226/463 (48%), Gaps = 21/463 (4%)

Query: 7   VLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVK--NHTFNLSA 64
           +L ++G+ G FQ Q  ++LC+L+          VF+     HHC    V   +     S 
Sbjct: 7   ILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWSP 66

Query: 65  AEQLVLSVP-LDTAGHP--EPCLMFRPP---PANASLQDILSHRFNETQ----PCDMGWE 114
           AE+L  +VP L  AG      C  +       A + +  + S   N +     PC  GW 
Sbjct: 67  AEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWV 126

Query: 115 YPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLL 174
           Y +    S+  EFNLVC      D  QS   AG L G+L  G   DR GRK  +L  +L+
Sbjct: 127 Y-DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLV 185

Query: 175 FTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFS 234
             + G+  AF P++   +  R        G   +  TL+TE+VG   R    ++ Q  F+
Sbjct: 186 NAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFT 245

Query: 235 LGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKA 294
           +G + L GLAY   +WR LQ+  + P  L   Y+W +PES RWLL++ R  EAI+++   
Sbjct: 246 VGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHI 305

Query: 295 ASVNRRKLSPELMNQL-----VPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYY 349
           A  N  KL P  +  L     V EK  PS    DLFR P+LRK T I+  +WF DS+ Y 
Sbjct: 306 AQKN-GKLPPADLKMLSLEEDVTEKLSPS--FADLFRTPRLRKRTFILMYLWFTDSVLYQ 362

Query: 350 GLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIF 409
           GL L +G    ++YL  L    VE+P    ++  + R GR +    + +L G  C+++IF
Sbjct: 363 GLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIF 422

Query: 410 IPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTG 452
           I  DL  +  ++  VG+M    A  +  + +AEL+PT +   G
Sbjct: 423 ISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVG 465


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  211 bits (538), Expect = 1e-54
 Identities = 115/309 (37%), Positives = 177/309 (57%), Gaps = 8/309 (2%)

Query: 215 EWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPES 274
           EW     R   + L    FS G  + A +AYG R+W LLQ+  + P  L F Y W L ES
Sbjct: 2   EWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAES 61

Query: 275 ARWLLTRGRMDEAIQLIQKAASVNRR-----KLSPELMNQLVPEKTG---PSGNALDLFR 326
           ARWLLT GR+D  +Q + + A++N +      L+PE++   + E+     P  +   L R
Sbjct: 62  ARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLR 121

Query: 327 HPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQR 386
            P LR  T I    WF     ++GL+L +   G +++L Q+  G V++PA+  ++ ++  
Sbjct: 122 MPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSH 181

Query: 387 FGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPT 446
            GR+ +   +L+L GL  +    +P ++  + + LAV+G     AAFT   +YS+ELFPT
Sbjct: 182 LGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPT 241

Query: 447 ILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQG 506
           +LR T +GL  + +R G IL PLV LLG +   LP+L+YG++P+++GL   LLPET    
Sbjct: 242 VLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLP 301

Query: 507 LKDTLQDLE 515
           L DT+QD++
Sbjct: 302 LPDTIQDVQ 310



 Score = 33.5 bits (75), Expect = 0.52
 Identities = 44/144 (30%), Positives = 62/144 (43%), Gaps = 14/144 (9%)

Query: 158 LCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVAT---AVAGLSFSNVTLLT 214
           L   +GR+ T+ A LLL  L  LA   VP      ALR A+A       G +F+ +T+ +
Sbjct: 178 LLSHLGRRPTLAASLLLAGLCILANTLVP--HEMGALRSALAVLGLGGVGAAFTCITIYS 235

Query: 215 EWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPES 274
             + P+      VL      LGQM   G A      RLL + G    LL++     L   
Sbjct: 236 SELFPT------VLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGL 289

Query: 275 ARWLLTRGR---MDEAIQLIQKAA 295
           A  LL   +   + + IQ +Q  A
Sbjct: 290 AALLLPETQSLPLPDTIQDVQNQA 313


>gi|24308167 SV2 related protein [Homo sapiens]
          Length = 548

 Score =  140 bits (352), Expect = 4e-33
 Identities = 107/401 (26%), Positives = 190/401 (47%), Gaps = 39/401 (9%)

Query: 142 SVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATA 201
           SV   G++  + ++G + D+ GRK  +   +L     G+ +AF P +   + LR  V   
Sbjct: 127 SVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFG 186

Query: 202 VAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLG---QMVLAGLAYGFRNWRLLQITGT 258
           + G+  S VTL  E++    R + ++L +  +++G   ++VLA        WR L I   
Sbjct: 187 IGGVPQS-VTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLILSA 245

Query: 259 APGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPS 318
            P LL     + LPESAR+ +  G  ++AI  +++ A+ N    +P  + +L+  +    
Sbjct: 246 VPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENG---APMPLGKLIISRQEDR 302

Query: 319 GNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSL------QVGD--------------- 357
           G   DLF  P  R  TL+++ +WF ++  YYGL L      Q GD               
Sbjct: 303 GKMRDLFT-PHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAVEAKC 361

Query: 358 ------FGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIP 411
                    + Y+  L     E P    +++++ R GRK +     V+    C +++FI 
Sbjct: 362 SLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSF-CSLLLFIC 420

Query: 412 ADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVI 471
               V+ T+L  + +   +  F  +YVY+ E++PT  R  G+G     +R+G ++TP + 
Sbjct: 421 VGRNVL-TLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIA 479

Query: 472 -LLGEYHAALPMLIYGSLPIVAGLLCTLLP-ETHGQGLKDT 510
            ++ E    L + +Y    ++A L    LP ET G+GL+++
Sbjct: 480 QVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  135 bits (340), Expect = 1e-31
 Identities = 133/482 (27%), Positives = 210/482 (43%), Gaps = 35/482 (7%)

Query: 64  AAEQLVLSVPLDTAGHPEP-CLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPS 122
           A+  L  S     A   +P C  F PP  N  L+D               W+Y  N LP 
Sbjct: 39  ASAALAASAASRVATSTDPSCSGFAPPDFNHCLKD---------------WDY--NGLPV 81

Query: 123 LKN----EFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLI 178
           L      +++LVCD        Q +F+ G   G L  G   DR GR+  +L  L L    
Sbjct: 82  LTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPC 141

Query: 179 GLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQM 238
           G+  A   S    MALRF +   +AG+      +  E   P+ R +  +  +     G  
Sbjct: 142 GVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHF 201

Query: 239 VLAGLAYGFRNWRLLQITGTAPGLLLFFYFW--ALPESARWLLTRGRMDEAIQLIQKAAS 296
           +  GLA   ++WR LQ   TAP +L  FY W     ESARWL+ + +++EA  +++  A 
Sbjct: 202 LFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAE 261

Query: 297 VNR---RKLSPELMNQLVP-EKTGP-----SGNALDLFRHPQLRKVTLII-FCVWFVDSL 346
            NR   + L  E    L   E T P     S +   L  +  + K  LI+ F  +   ++
Sbjct: 262 RNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAI 321

Query: 347 GYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCII 406
            +    +  G    D YL  L+       A       + RFGR+   L ++ L G+  ++
Sbjct: 322 RHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLV 381

Query: 407 IIFIPADL-PVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGI 465
           ++ +   L    +T  +V+G  ++ AA  +S + +AE+ PT +R  G+GL+     +GG+
Sbjct: 382 LLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGL 441

Query: 466 LTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKS 525
             P   L   + A L  ++  +  ++  L   LLPET  + L + L+D EL   P   + 
Sbjct: 442 SGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQ 501

Query: 526 VP 527
            P
Sbjct: 502 PP 503


>gi|21361834 solute carrier family 22, member 17 isoform a [Homo
           sapiens]
          Length = 538

 Score =  129 bits (325), Expect = 5e-30
 Identities = 133/500 (26%), Positives = 212/500 (42%), Gaps = 53/500 (10%)

Query: 64  AAEQLVLSVPLDTAGHPEP-CLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPS 122
           A+  L  S     A   +P C  F PP  N  L+D               W+Y  N LP 
Sbjct: 39  ASAALAASAASRVATSTDPSCSGFAPPDFNHCLKD---------------WDY--NGLPV 81

Query: 123 LKN----EFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLI 178
           L      +++LVCD        Q +F+ G   G L  G   DR GR+  +L  L L    
Sbjct: 82  LTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPC 141

Query: 179 GLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQM 238
           G+  A   S    MALRF +   +AG+      +  E   P+ R +  +  +     G  
Sbjct: 142 GVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHF 201

Query: 239 VLAGLAYGFRNWRLLQITGTAPGLLLFFYFW--ALPESARWLLTRGRMDEAIQLIQKAAS 296
           +  GLA   ++WR LQ   TAP +L  FY W     ESARWL+ + +++EA  +++  A 
Sbjct: 202 LFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAE 261

Query: 297 VNR---RKLSPELMNQLVP-EKTGP-----SGNALDLFRHPQLRKVTLII-FCVWFVDSL 346
            NR   + L  E    L   E T P     S +   L  +  + K  LI+ F  +   ++
Sbjct: 262 RNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAI 321

Query: 347 GYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCII 406
            +    +  G    D YL  L+       A       + RFGR+   L ++ L G+  ++
Sbjct: 322 RHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLV 381

Query: 407 IIFI-PADLPV------------------VVTMLAVVGKMATAAAFTISYVYSAELFPTI 447
           ++ +   + P+                   +T  +V+G  ++ AA  +S + +AE+ PT 
Sbjct: 382 LLGLWDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTT 441

Query: 448 LRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGL 507
           +R  G+GL+     +GG+  P   L   + A L  ++  +  ++  L   LLPET  + L
Sbjct: 442 VRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLL 501

Query: 508 KDTLQDLELGPHPRSPKSVP 527
            + L+D EL   P   +  P
Sbjct: 502 PEVLRDGELCRRPSLLRQPP 521


>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score =  121 bits (303), Expect = 2e-27
 Identities = 121/413 (29%), Positives = 189/413 (45%), Gaps = 32/413 (7%)

Query: 127 FNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVP 186
           +NLVC         Q   + G L+G ++ G  CDR GR+A  +A L+L T +G + A   
Sbjct: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178

Query: 187 SFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYG 246
           SF   + LR      +AG   +      E   P  R    + A     +G ++L GLA  
Sbjct: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238

Query: 247 FRNWRLLQITGTAPG--LLLFFYFWAL-PESARWLLTRGRMDEAIQLIQKAASVNRRKLS 303
            ++WRLLQ  G      LLLF+ F AL PES  WLL  G++  A +++ + A  +   + 
Sbjct: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS--GVG 296

Query: 304 PELMNQLVPEKTGPSGNALDLF--RHPQLR----------KVTLIIFCVWFVDSLGYYG- 350
           P   +  + E +  +   L +   R PQ R          +VT     +    SL   G 
Sbjct: 297 PG--DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGI 354

Query: 351 -------LSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLM 403
                  L+ QV  F    YL   +   +E  A    +      GR+   L   ++ GL 
Sbjct: 355 RASFRRSLAPQVPTF----YLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLA 410

Query: 404 CIIIIFIPADLP-VVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRI 462
            ++++     LP   V  L+V+G +A+ A   +S +++AE+FPT++R  G+GLV     +
Sbjct: 411 SLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFL 470

Query: 463 GGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515
           G    PL  L G     L  +++ SL ++A L   LLPE+  +GL  +LQD +
Sbjct: 471 GQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDAD 523


>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
          Length = 492

 Score =  120 bits (300), Expect = 4e-27
 Identities = 109/406 (26%), Positives = 180/406 (44%), Gaps = 43/406 (10%)

Query: 140 TQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVA 199
           T  VF  G +V +++FG L DR GR   +L   L      L T+F PS+  ++ LR  V 
Sbjct: 90  TTMVFF-GYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVG 148

Query: 200 TAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFR---NWRLLQIT 256
             V+G S   + + TE++   +R   + L+Q  +  G +++ GLA        WR L   
Sbjct: 149 CGVSGHS-QGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRV 207

Query: 257 GTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTG 316
            + PG++L   F  +PESAR+ ++ G    A+  +++ A +NR  +    + + V EK G
Sbjct: 208 ASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRG 267

Query: 317 PSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDF-----------GLDVYLT 365
              + LD     +  + TL I+ +W   S  YYG+ L   +               V +T
Sbjct: 268 RFADLLD----AKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVT 323

Query: 366 QLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTM----- 420
               G  + P  C             S +G + L  L  + I F+   L + +TM     
Sbjct: 324 GGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTAL 383

Query: 421 -----------LAVVG-----KMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGG 464
                        ++G     +   AA F   Y+Y+AE++PT +R  GMG  G   RIG 
Sbjct: 384 FFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGA 443

Query: 465 ILTPLVILLGEYHAALPML-IYGSLPIVAGLLCTLLP-ETHGQGLK 508
           ++ P +  +    + L  L ++ S+ +V  +    LP ET G+ L+
Sbjct: 444 MVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQ 489


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.141    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,852,854
Number of Sequences: 37866
Number of extensions: 955749
Number of successful extensions: 3115
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 2913
Number of HSP's gapped (non-prelim): 95
length of query: 551
length of database: 18,247,518
effective HSP length: 107
effective length of query: 444
effective length of database: 14,195,856
effective search space: 6302960064
effective search space used: 6302960064
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.