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Search of human proteins with 164565408
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
(1386 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 2821 0.0
gi|71274148 pleckstrin homology domain containing, family G (wit... 333 9e-91
gi|55749621 pleckstrin homology domain containing, family G, mem... 265 2e-70
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 122 2e-27
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 119 2e-26
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 119 2e-26
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 117 6e-26
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 117 8e-26
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 117 1e-25
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 115 2e-25
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 113 1e-24
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 113 1e-24
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 112 2e-24
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 112 2e-24
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 107 6e-23
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 106 2e-22
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 106 2e-22
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi... 104 5e-22
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi... 104 5e-22
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 94 7e-19
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 94 7e-19
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 94 7e-19
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 94 1e-18
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 94 1e-18
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 92 3e-18
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ... 91 6e-18
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 91 1e-17
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 90 2e-17
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 87 8e-17
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 87 1e-16
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 2821 bits (7313), Expect = 0.0
Identities = 1386/1386 (100%), Positives = 1386/1386 (100%)
Query: 1 MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLSTVGS 60
MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLSTVGS
Sbjct: 1 MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLSTVGS 60
Query: 61 EGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRD 120
EGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRD
Sbjct: 61 EGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRD 120
Query: 121 LRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFV 180
LRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFV
Sbjct: 121 LRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFV 180
Query: 181 QRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRI 240
QRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRI
Sbjct: 181 QRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRI 240
Query: 241 LKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRL 300
LKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRL
Sbjct: 241 LKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRL 300
Query: 301 GGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHI 360
GGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHI
Sbjct: 301 GGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHI 360
Query: 361 FCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPA 420
FCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPA
Sbjct: 361 FCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPA 420
Query: 421 KAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRR 480
KAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRR
Sbjct: 421 KAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRR 480
Query: 481 QSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGT 540
QSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGT
Sbjct: 481 QSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGT 540
Query: 541 SITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEE 600
SITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEE
Sbjct: 541 SITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEE 600
Query: 601 GLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLS 660
GLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLS
Sbjct: 601 GLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLS 660
Query: 661 DISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGK 720
DISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGK
Sbjct: 661 DISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGK 720
Query: 721 LGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLA 780
LGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLA
Sbjct: 721 LGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLA 780
Query: 781 RPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRASA 840
RPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRASA
Sbjct: 781 RPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRASA 840
Query: 841 NAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQ 900
NAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQ
Sbjct: 841 NAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQ 900
Query: 901 AAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEG 960
AAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEG
Sbjct: 901 AAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEG 960
Query: 961 PLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAFCPEQGHCADIHVPTTP 1020
PLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAFCPEQGHCADIHVPTTP
Sbjct: 961 PLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAFCPEQGHCADIHVPTTP 1020
Query: 1021 ALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSW 1080
ALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSW
Sbjct: 1021 ALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSW 1080
Query: 1081 HGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQV 1140
HGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQV
Sbjct: 1081 HGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQV 1140
Query: 1141 PATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLEQ 1200
PATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLEQ
Sbjct: 1141 PATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLEQ 1200
Query: 1201 KSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPH 1260
KSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPH
Sbjct: 1201 KSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPH 1260
Query: 1261 SPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPP 1320
SPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPP
Sbjct: 1261 SPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPP 1320
Query: 1321 PQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGAP 1380
PQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGAP
Sbjct: 1321 PQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGAP 1380
Query: 1381 DAPFHM 1386
DAPFHM
Sbjct: 1381 DAPFHM 1386
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 333 bits (853), Expect = 9e-91
Identities = 188/371 (50%), Positives = 242/371 (65%), Gaps = 13/371 (3%)
Query: 63 DPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRL---ERVAREIVETERAYVR 119
+PA G A S P + + +P I SA +L +RV +EI+ETER YV+
Sbjct: 71 NPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQ 130
Query: 120 DLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLEN-SSSAGGIAEC 178
DL+SIVEDYL + D L L E+ LF NI+DIY F+SELL+DLEN + IAEC
Sbjct: 131 DLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAEC 190
Query: 179 FVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQ 238
FV +SE+F IYT YC NYP S+A+L E + A + +ERQ L+HSLPL S+LLKPVQ
Sbjct: 191 FVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQ 250
Query: 239 RILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQR 298
RILKYHLLL E+ H + T G ++V +AI +M VAW+INDMKRK EHA RLQE+Q
Sbjct: 251 RILKYHLLLHEIENHLDK--DTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQS 308
Query: 299 RLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKG 358
L W GP+L+++GELVLEG FR + ER LFLF ++LL+ K+R +TYK
Sbjct: 309 LLTNWKGPDLTSYGELVLEGTFR------IQRAKNERTLFLFDKLLLITKKRDDTFTYKA 362
Query: 359 HIFCCNLSVSE-SPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPAS 417
HI C NL + E P++PL F V PK +H +QAK+Q++KRLW+ L+RL ENH A
Sbjct: 363 HILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAK 422
Query: 418 IPAKAKQVLLE 428
IPAKAKQ +LE
Sbjct: 423 IPAKAKQAILE 433
>gi|55749621 pleckstrin homology domain containing, family G, member
3 [Homo sapiens]
Length = 1163
Score = 265 bits (677), Expect = 2e-70
Identities = 263/890 (29%), Positives = 378/890 (42%), Gaps = 189/890 (21%)
Query: 125 VEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFVQRSE 184
V+ L P G + ++ L + +I E ++DL + + S+
Sbjct: 71 VKGPLSPFNSRAAAGPAHHKLSYLGRVVREIVETERMYVQDLRS-----------IVESQ 119
Query: 185 DFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYH 244
+FDIYT YC NYP+S+A L E A + ++RQ L+HSLPL S+LLKPVQRILKYH
Sbjct: 120 EFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYH 179
Query: 245 LLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWT 304
LLLQE+ KH+ E G E+VE+AI +MT VAWYINDMKR+ EHA RLQE+Q L W
Sbjct: 180 LLLQEIAKHFDEEED--GFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWK 237
Query: 305 GPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHIFCCN 364
GP+L+ +GELVLEG FR R+R ER FLF + LL+ K+RG + YKG+I C +
Sbjct: 238 GPDLTTYGELVLEGTFRVH-----RVRN-ERTFFLFDKTLLITKKRGDHFVYKGNIPCSS 291
Query: 365 LSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQ 424
L + ES RD L F V+ K ++ +QAK EEKR W H ++RL ENH A+IP KAK+
Sbjct: 292 LMLIESTRDSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILENHHATIPQKAKE 351
Query: 425 VLLE------NSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSP-------- 470
+LE N C+P+ S + + + GRR + P+
Sbjct: 352 AILEMDSYYPNRYRCSPER-------LKKAWSSQDEVSTNVRQGRRQSEPTKHLLRQLNE 404
Query: 471 ---GPSVIRRGRRQSEPVKD---PYVMFPQNAKPGFK--------------HAGSEGELY 510
+ +GRR+SE + P P + + AGSE E++
Sbjct: 405 KARAAGMKGKGRRESESSRSSRRPSGRSPTSTEKRMSFESISSLPEVEPDPEAGSEQEVF 464
Query: 511 P----PESQPPVSGSAPPEDLE---DA--GPPTLDPSGTSI------TEEILELLNQRGL 555
P ++ S + PE LE DA G +DP G + + E L+ L+
Sbjct: 465 SAVEGPSAEETPSDTESPEVLETQLDAHQGLLGMDPPGDMVDFVAAESTEDLKALSSEEE 524
Query: 556 RDPGPSTHDIPKFPGDSQVPGDSETLTFQALPS---RDSSEEEEEEEEGL---EMDERGP 609
+ G + + P+ V + + + + S R S +E+ + G + R
Sbjct: 525 EEMGGAAQE-PESLLPPSVLDQASVIAERFVSSFSRRSSVAQEDSKSSGFGSPRLVSRSS 583
Query: 610 SPLHVLEGLESSIA---AEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLSDISDVF 666
S L LEG E +A + S+ C PE+ + PS++ +
Sbjct: 584 SVLS-LEGSEKGLARHGSATDSLSCQLS-------PEVDISVGVATEDS-PSVNGME--- 631
Query: 667 EMPCLPAIPSVPNTPS-------LSSTPTLSCD---SWLQGPLQEPAEAPATRRELFSGS 716
P P P P+ S LS+ L D S+ + A RRE S
Sbjct: 632 --PPSPGCPVEPDRSSCKKKESALSTRDRLLLDKIKSYYENAEHHDAGFSVRRRESLSYI 689
Query: 717 NPGKLGEPPSGGKAGPEEDEEGV--------------SFTDFQPQDVTQH-QGFPDELA- 760
G + S + P D E V S+ F+ +Q +G P ++
Sbjct: 690 PKGLVRNSISRFNSLPRPDPEPVPPVGSKRQVGSRPTSWALFELPGPSQAVKGDPPPISD 749
Query: 761 --FRSCSEIRSAWQALE-----------QGQLARPGFPEPLLILEDSDLGGDSGSGKAGA 807
FR SEI W+ +E QGQ EPL ILE+ +LG + +
Sbjct: 750 AEFRPSSEIVKIWEGMESSGGSPGKGPGQGQANGFDLHEPLFILEEHELGAITEESATAS 809
Query: 808 PSS---------------------------------------------------ERTASR 816
P S ER ++
Sbjct: 810 PESSSPTEGRSPAHLARELKELVKELSSSTQGELVAPLHPRIVQLSHVMDSHVSERVKNK 869
Query: 817 VRELARLYSERIQQMQRAETRASANAPRRRPRVLAQPQPSPCLPQEQAEP 866
V +LAR YS RI+ + R + P + PCL +E EP
Sbjct: 870 VYQLARQYSLRIKSNKPVMARPPLQWEKVAPERDGKSPTVPCLQEEAGEP 919
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 122 bits (306), Expect = 2e-27
Identities = 105/324 (32%), Positives = 149/324 (45%), Gaps = 40/324 (12%)
Query: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLED 165
V REI++TER Y++ LR I E Y+ + +V Q+ T+F NIEDIY+F + L+D
Sbjct: 244 VIREIMDTERVYIKHLRDICEGYIRQCRKHTGM-FTVAQLATIFGNIEDIYKFQRKFLKD 302
Query: 166 LENSSS-----AGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQE-R 219
LE + I CF+Q E F IY+ YC N+P + L L + + R
Sbjct: 303 LEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACR 362
Query: 220 QAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWY 279
Q + + FLL PVQ+I KY L L EL K+ + G ++ A +M VA
Sbjct: 363 LLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSN--IKAAYEAMKNVACL 420
Query: 280 INDMKRKQEHAARLQEVQRRLGGWTGPE-LSAFGELVLEGAFRGGGGGGPRLRGGERLLF 338
IN+ KRK E ++ Q + GW G + L EL+ G G + +R F
Sbjct: 421 INERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQG---KSQQRTFF 477
Query: 339 LFSRMLLVAK----RRGLEYTYKGHIFC---------------CNLSVSESPRDPLGFKV 379
LF L+ K RR + Y YKG + CNLSV + FK+
Sbjct: 478 LFDHQLVSCKKDLLRRDMLY-YKGRLDMDEMELVDLGDGRDKDCNLSVKNA------FKL 530
Query: 380 SDLTIPKHRHLLQAKNQEEKRLWI 403
T + +L AK QE+K W+
Sbjct: 531 VSRTTDE-VYLFCAKKQEDKARWL 553
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 119 bits (298), Expect = 2e-26
Identities = 133/475 (28%), Positives = 215/475 (45%), Gaps = 79/475 (16%)
Query: 106 VAREIVETERAYVRDLRSIVEDYLGPL---LDGGVLGLSVE-QVGTLFANIEDIYEFSSE 161
V E+++TERAYV +L ++E Y + L +L + + LF N+E+IY F +
Sbjct: 662 VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNR 721
Query: 162 L-LEDLENSSSAGG-IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQER 219
+ L +LEN + + CF++R EDF IY YC N P S +L R+ S P + QE
Sbjct: 722 IFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCP----FFQEC 777
Query: 220 QAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWY 279
Q +L H L L S+LLKPVQRI KY LLL+E+ K+ G E ++EA+ S+ +
Sbjct: 778 QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKY---SRNCEGAEDLQEALSSILGILKA 834
Query: 280 INDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAF-------RGGGGGG--PRL 330
+ND H + G+ G L G+L+++G+F RG R
Sbjct: 835 VND----SMHLIAIT-------GYDG-NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARF 882
Query: 331 RGGERLLFLFSRMLLVAKRR-----GLE----YTYKGHIFCCNLSVSESPR-DPLGFKVS 380
+ +R LFL + +L K+R G E Y+YK + + ++E+ + D F++
Sbjct: 883 KPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIW 942
Query: 381 DLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPV 440
+ +++QA E K W++ ++++ Q E S H A +
Sbjct: 943 -YNAREEVYIVQAPTPEIKAAWVNEIRKVL---------TSQLQACREASQHRALEQSQS 992
Query: 441 LEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRRQSEPVK-DPYVMFPQNAKPG 499
L PL +P S +P R N+ ++ + R+++P+ + YV KP
Sbjct: 993 L-----PLPAP-----TSTSPSRGNSR-----NIKKLEERKTDPLSLEGYVSSAPLTKPP 1037
Query: 500 FKHAG---SEGELYPPESQPPVSGSAPPEDLEDA------GPPTLDPSGTSITEE 545
K G + L PE S + + DA GP L P ++ +
Sbjct: 1038 EKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVAD 1092
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 119 bits (298), Expect = 2e-26
Identities = 133/475 (28%), Positives = 215/475 (45%), Gaps = 79/475 (16%)
Query: 106 VAREIVETERAYVRDLRSIVEDYLGPL---LDGGVLGLSVE-QVGTLFANIEDIYEFSSE 161
V E+++TERAYV +L ++E Y + L +L + + LF N+E+IY F +
Sbjct: 609 VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNR 668
Query: 162 L-LEDLENSSSAGG-IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQER 219
+ L +LEN + + CF++R EDF IY YC N P S +L R+ S P + QE
Sbjct: 669 IFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCP----FFQEC 724
Query: 220 QAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWY 279
Q +L H L L S+LLKPVQRI KY LLL+E+ K+ G E ++EA+ S+ +
Sbjct: 725 QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKY---SRNCEGAEDLQEALSSILGILKA 781
Query: 280 INDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAF-------RGGGGGG--PRL 330
+ND H + G+ G L G+L+++G+F RG R
Sbjct: 782 VND----SMHLIAIT-------GYDG-NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARF 829
Query: 331 RGGERLLFLFSRMLLVAKRR-----GLE----YTYKGHIFCCNLSVSESPR-DPLGFKVS 380
+ +R LFL + +L K+R G E Y+YK + + ++E+ + D F++
Sbjct: 830 KPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIW 889
Query: 381 DLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPV 440
+ +++QA E K W++ ++++ Q E S H A +
Sbjct: 890 -YNAREEVYIVQAPTPEIKAAWVNEIRKVL---------TSQLQACREASQHRALEQSQS 939
Query: 441 LEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRRQSEPVK-DPYVMFPQNAKPG 499
L PL +P S +P R N+ ++ + R+++P+ + YV KP
Sbjct: 940 L-----PLPAP-----TSTSPSRGNSR-----NIKKLEERKTDPLSLEGYVSSAPLTKPP 984
Query: 500 FKHAG---SEGELYPPESQPPVSGSAPPEDLEDA------GPPTLDPSGTSITEE 545
K G + L PE S + + DA GP L P ++ +
Sbjct: 985 EKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVAD 1039
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 117 bits (294), Expect = 6e-26
Identities = 118/393 (30%), Positives = 174/393 (44%), Gaps = 37/393 (9%)
Query: 97 SARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIY 156
S++ V EI+ TER Y++ LR I E Y+ + S EQ+ T+F NIEDIY
Sbjct: 279 SSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADM-FSEEQLRTIFGNIEDIY 337
Query: 157 EFSSELLEDLENSSSA-----GGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELS-LSP 210
++ LE + + CF++ DF IY+ YC N+P++ L L+ LS
Sbjct: 338 RCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSK 397
Query: 211 PAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAI 270
+ R Q + L FLL PVQ+I KY L L EL K+ P + VE A+
Sbjct: 398 YVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKY--THPQHRDFKDVEAAL 455
Query: 271 VSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSA-FGELVLEGAFRGGGGGGPR 329
+M VA IN+ KR+ E+ ++ + Q + W G +L EL+ G P+
Sbjct: 456 HAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELT--RVTQPQ 513
Query: 330 LRGGERLLFLFSRMLLVAK----RRGLEYTYKGHIFCCNLSV--SESPRD-PLGFKVSDL 382
+ +R+ FLF L+ K RR + Y YKG + L V E +D L + +
Sbjct: 514 AKSQQRMFFLFDHQLIYCKKDLLRRDVLY-YKGRLDMDGLEVVDLEDGKDRDLHVSIKN- 571
Query: 383 TIPKHR------HLLQAKNQEEKRLWIHCLQR------LFFENHPASIPAKAKQVLLENS 430
HR HLL + E+K+ W+ R L E + + KQ +L S
Sbjct: 572 AFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQETGFSITELQRKQAMLNAS 631
Query: 431 ---LHCAPKSKPVLEPLTPPLGSPRPRDARSFT 460
+ PK + P P L P P D F+
Sbjct: 632 KQQVTGKPKGRRTAAP-PPRLPGPYPADIIPFS 663
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 117 bits (293), Expect = 8e-26
Identities = 104/326 (31%), Positives = 147/326 (45%), Gaps = 39/326 (11%)
Query: 40 APTMASPRGSGSSTSLSTVGSEGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSAR 99
AP+ + P G G+ GD A A A+ P PGP S R
Sbjct: 3 APSGSEPGGDGA----------GDCAHPDPRAPGAAAPSSGPGPCAAAR-------ESER 45
Query: 100 PSRLER-VAREIVETERAYVRDLRSIVEDYLGPL----LDGGVLGLSVEQVGTLFANIED 154
RL V EI+ TER YV LR + +L + D GL+ E V LF+NIED
Sbjct: 46 QLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIED 105
Query: 155 IYEFSSELLEDLE-----NSSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLS 209
I E + L LE S + F++ + F +Y YC N+ +L LL EL+
Sbjct: 106 ILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKI 165
Query: 210 PPAALWLQERQ---AQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGT-GGREM 265
P +L + +PL+ +LL P+QRI KY LLL+EL K PG
Sbjct: 166 PTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAK---RTPGKHPDHPA 222
Query: 266 VEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAF-GELVLEGAFRGGG 324
V+ A+ +M V IN+ KR+ E L+++Q + GW G L+ +L+L+G
Sbjct: 223 VQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKIS 282
Query: 325 GGGPRLRGGERLLFLFSRMLLVAKRR 350
G + ER FLF +L+ KR+
Sbjct: 283 AGNIQ----ERAFFLFDNLLVYCKRK 304
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 117 bits (292), Expect = 1e-25
Identities = 120/428 (28%), Positives = 191/428 (44%), Gaps = 77/428 (17%)
Query: 77 PEPLPGPPIRLHLSPVGIPGSARPS--RLERVAREIVETERAYVRDLRSIVEDYLGPLLD 134
P +PG ++L + + R S R E + E+++TE+AYVRDLR ++ YL +
Sbjct: 1265 PASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTS 1324
Query: 135 G------GVLGLSVEQVGTLFANIEDIYEFSSEL-LEDLENSSSAG-GIAECFVQRSEDF 186
G G++ + +F N+++IYEF + + L++LE + CFV ++ F
Sbjct: 1325 GVEEIPPGIVNKEL----IIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKF 1380
Query: 187 DIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLP--LQSFLLKPVQRILKYH 244
+Y YC N P S L+ E A + E Q RH L + S+L+KPVQRI KY
Sbjct: 1381 QMYVTYCKNKPDSTQLILE-----HAGSYFDE--IQQRHGLANSISSYLIKPVQRITKYQ 1433
Query: 245 LLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWT 304
LLL+EL EG G +++ + M +V ND H + L+
Sbjct: 1434 LLLKELLTCCEEGKGE-----IKDGLEVMLSVPKRANDAM----HLSMLEGFDE------ 1478
Query: 305 GPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKR-----RGLEYTYKGH 359
+ + GEL+L+ +F+ +G ER LFLF L+ +K +Y YK
Sbjct: 1479 --NIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSK 1536
Query: 360 IFCCNLSVSESPR-DPLGFK--VSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPA 416
+F L V+E DP F V ++ +L+A + E K+ WI +
Sbjct: 1537 LFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHI---------- 1586
Query: 417 SIPAKAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIR 476
++V+ E ++H K EP+ P +P R GRR+ G +
Sbjct: 1587 ------REVIQERTIHLKGALK---EPIHIPKTAPATRQ-----KGRRD-----GEDLDS 1627
Query: 477 RGRRQSEP 484
+G S+P
Sbjct: 1628 QGDGSSQP 1635
Score = 101 bits (252), Expect = 4e-21
Identities = 168/673 (24%), Positives = 254/673 (37%), Gaps = 129/673 (19%)
Query: 90 SPVGIPGSARPSRLER---VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVG 146
SP+ + S L+R V +E+VETER YVRDL +VE Y+ + + GV +
Sbjct: 1954 SPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDK 2013
Query: 147 TLFANIEDIYE-----FSSELLEDLENSSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLA 201
+F NI IY+ F EL + LE+ G + FV+ +Y YC N P S
Sbjct: 2014 IVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSL---FVKHERRLHMYIAYCQNKPKSEH 2070
Query: 202 LLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTG 261
++ E + ++ + +L H L L L+KPVQRI+KY LLL++ K+ +
Sbjct: 2071 IVSEY-----IDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKY--SKKASL 2123
Query: 262 GREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAF- 320
+E A+ M V NDM + RLQ G+ G ++ A G+L+L+ F
Sbjct: 2124 DTSELERAVEVMCIVPRRCNDMM----NVGRLQ-------GFDG-KIVAQGKLLLQDTFL 2171
Query: 321 --RGGGGGGPRLRGGERLLFLFSRMLLVA----KRRGLE---YTYKGHIFCCNLSVSES- 370
G PR R ER +FLF ++++ + K++G + +K I L + E+
Sbjct: 2172 VTDQDAGLLPRCR--ERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENV 2229
Query: 371 PRDPLGFKVSDLT-IPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLEN 429
DP F ++ T +L + + ++ WIH + + +LEN
Sbjct: 2230 ENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQ-----------------ILEN 2272
Query: 430 SLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRRQSEPVKDPY 489
+ L LT P+ R G + G
Sbjct: 2273 -------QRNFLNALTSPIEYQRNHSGGGGGGGSGGSGGGGG------------------ 2307
Query: 490 VMFPQNAKPGFKHAGSEGELYPPES---QPPVSGSAP---PEDLEDAGPPTLDPSGTSIT 543
+ G +G G P S P S S P P+ + PP L S S
Sbjct: 2308 ------SGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSRIPQPVRH-HPPVLVSSAASSQ 2360
Query: 544 EEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLE 603
E ++ G PGPS P P +A PS S + EG E
Sbjct: 2361 AEADKM---SGTSTPGPS------LPPPGAAP--------EAGPSAPSRRPPGADAEGSE 2403
Query: 604 MDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGS-RLPSLSDI 662
+ + VLE A S PD P S +P G R + S +
Sbjct: 2404 REAEPIPKMKVLESPRKGAANASGS------SPDAPAKDARASLGTLPLGKPRAGAASPL 2457
Query: 663 SDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGKLG 722
+ P A+PS+ P S+P S+ PA P + F G +
Sbjct: 2458 NS----PLSSAVPSLGKEPFPPSSPLQKGGSFWSSIPASPASRPGS--FTFPGDSDSLQR 2511
Query: 723 EPPSGGKAGPEED 735
+ P G + D
Sbjct: 2512 QTPRHAAPGKDTD 2524
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 115 bits (289), Expect = 2e-25
Identities = 103/332 (31%), Positives = 153/332 (46%), Gaps = 27/332 (8%)
Query: 97 SARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIY 156
S++ V EI+ TER Y++ LR I E Y+ + S EQ+ T+F NIEDIY
Sbjct: 279 SSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADM-FSEEQLRTIFGNIEDIY 337
Query: 157 EFSSELLEDLENSSSA-----GGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELS-LSP 210
++ LE + + CF++ DF IY+ YC N+P++ L L+ LS
Sbjct: 338 RCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSK 397
Query: 211 PAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAI 270
+ R Q + L FLL PVQ+I KY L L EL K+ P + VE A+
Sbjct: 398 YVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKY--THPQHRDFKDVEAAL 455
Query: 271 VSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSA-FGELVLEGAFRGGGGGGPR 329
+M VA IN+ KR+ E+ ++ + Q + W G +L EL+ G P+
Sbjct: 456 HAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELT--RVTQPQ 513
Query: 330 LRGGERLLFLFSRMLLVAK----RRGLEYTYKGHIFCCNLSV--SESPRD-PLGFKVSDL 382
+ +R+ FLF L+ K RR + Y YKG + L V E +D L + +
Sbjct: 514 AKSQQRMFFLFDHQLIYCKKDLLRRDVLY-YKGRLDMDGLEVVDLEDGKDRDLHVSIKN- 571
Query: 383 TIPKHR------HLLQAKNQEEKRLWIHCLQR 408
HR HLL + E+K+ W+ R
Sbjct: 572 AFRLHRGATGDSHLLCTRKPEQKQRWLKAFAR 603
>gi|153791628 MCF.2 cell line derived transforming sequence isoform
a [Homo sapiens]
Length = 985
Score = 113 bits (282), Expect = 1e-24
Identities = 82/260 (31%), Positives = 136/260 (52%), Gaps = 34/260 (13%)
Query: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSV----EQVGTLFANIEDIYEFSSE 161
V E+++TER YVR+L +++ Y + + + L + LF N+ +IYEF ++
Sbjct: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
Query: 162 L-LEDLENSSSAGG-IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQER 219
+ L LEN + A + CF++R +DF +Y YC N P S + R+ S + QE
Sbjct: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYS----ECAFFQEC 674
Query: 220 QAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWY 279
Q +L+H L L S+LLKPVQRI KY LLL+EL K+ + G+ ++++A+ +M +
Sbjct: 675 QRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSA---LLKKALDAMLDLLKS 731
Query: 280 INDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFR---GGGGGG------PRL 330
+ND Q + G+ G L+ G+++++G F G G R
Sbjct: 732 VNDSMH-----------QIAINGYIG-NLNELGKMIMQGGFSVWIGHKKGATKMKDLARF 779
Query: 331 RGGERLLFLFSRMLLVAKRR 350
+ +R LFL+ + ++ KRR
Sbjct: 780 KPMQRHLFLYEKAIVFCKRR 799
>gi|153791325 MCF.2 cell line derived transforming sequence isoform
b [Homo sapiens]
Length = 925
Score = 113 bits (282), Expect = 1e-24
Identities = 82/260 (31%), Positives = 136/260 (52%), Gaps = 34/260 (13%)
Query: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSV----EQVGTLFANIEDIYEFSSE 161
V E+++TER YVR+L +++ Y + + + L + LF N+ +IYEF ++
Sbjct: 499 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 558
Query: 162 L-LEDLENSSSAGG-IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQER 219
+ L LEN + A + CF++R +DF +Y YC N P S + R+ S + QE
Sbjct: 559 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYS----ECAFFQEC 614
Query: 220 QAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWY 279
Q +L+H L L S+LLKPVQRI KY LLL+EL K+ + G+ ++++A+ +M +
Sbjct: 615 QRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSA---LLKKALDAMLDLLKS 671
Query: 280 INDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFR---GGGGGG------PRL 330
+ND Q + G+ G L+ G+++++G F G G R
Sbjct: 672 VNDSMH-----------QIAINGYIG-NLNELGKMIMQGGFSVWIGHKKGATKMKDLARF 719
Query: 331 RGGERLLFLFSRMLLVAKRR 350
+ +R LFL+ + ++ KRR
Sbjct: 720 KPMQRHLFLYEKAIVFCKRR 739
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 112 bits (280), Expect = 2e-24
Identities = 101/327 (30%), Positives = 153/327 (46%), Gaps = 46/327 (14%)
Query: 104 ERVAREIVETERAYVRDLRSIVEDYLGPLLDG------GVLGLSVEQVGTLFANIEDIYE 157
E + E+++TE+AYVRDL +E YL + G G+L + +F NI++IY+
Sbjct: 1283 EFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILN----KEHIIFGNIQEIYD 1338
Query: 158 FSSEL-LEDLENSSSAG-GIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALW 215
F + + L++LE + CFV ++ F +Y YC N P S L+ E A +
Sbjct: 1339 FHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILE-----HAGTF 1393
Query: 216 LQERQAQLRHSLP--LQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSM 273
E Q RH L + S+L+KPVQRI KY LLL+EL EG G +++ + M
Sbjct: 1394 FDE--IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE-----LKDGLEVM 1446
Query: 274 TAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGG 333
+V ND H + L+ L GEL+L+ AF+ +G
Sbjct: 1447 LSVPKKANDAM----HVSMLEGFDE--------NLDVQGELILQDAFQVWDPKSLIRKGR 1494
Query: 334 ERLLFLFSRMLLVAKR-----RGLEYTYKGHIFCCNLSVSESPR-DPLGFKVSDLTIPK- 386
ER LFLF L+ +K +Y YK + L V+E DP F + P
Sbjct: 1495 ERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSS 1554
Query: 387 -HRHLLQAKNQEEKRLWIHCLQRLFFE 412
++ +L+A N E K+ WI ++ + E
Sbjct: 1555 DNKTVLKASNIETKQEWIKNIREVIQE 1581
Score = 94.4 bits (233), Expect = 7e-19
Identities = 113/432 (26%), Positives = 189/432 (43%), Gaps = 62/432 (14%)
Query: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSEL-LE 164
V E+V+TE+ YV+DL +VE ++ + + GV + +F NI IY++ + L
Sbjct: 1933 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLA 1992
Query: 165 DLENS-SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQL 223
+LE +A+ F++ IY YC N P S ++ E + +E + ++
Sbjct: 1993 ELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDA------YFEEVKQEI 2046
Query: 224 RHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDM 283
L L FL+KP+QRI KY LLL++ ++E G + +E+A+ M V NDM
Sbjct: 2047 NQRLTLSDFLIKPIQRITKYQLLLKDF-LRYSEKAGLECSD-IEKAVELMCLVPKRCNDM 2104
Query: 284 KRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRG-GGGGGPRLRGGERLLFLFSR 342
RL G+ G L+A G+L+ + F G + R ER +FLF +
Sbjct: 2105 MN-----------LGRLQGFEG-TLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQ 2152
Query: 343 MLLVAK--RRGL---EYTYKGHIFCCNLSVSES-PRDPLGFKVSDLTIPKHRHLLQAKNQ 396
+++ ++ R+G Y +K I L + E+ DP F + + R +LQA N
Sbjct: 2153 IVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRE-TSERVVLQAANA 2211
Query: 397 EEKRLWIHCL------QRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVL--EPLTPPL 448
+ ++ W+ + QR F + I + K+ +S V+ +P P
Sbjct: 2212 DIQQAWVQDINQVLETQRDFLNALQSPIEYQRKE-----------RSTAVMRSQPARLPQ 2260
Query: 449 GSPRPRDARSFTPGRRNTAPSPGPSVIRRGRRQSEPVKDPYVMFPQNAKPGFKHAGSEGE 508
SPRP S P P +G + P+ P + N PGF++ G+
Sbjct: 2261 ASPRP---YSSVPAGSEKPP--------KGSSYNPPL-PPLKISTSNGSPGFEY-HQPGD 2307
Query: 509 LYPPESQPPVSG 520
+ Q + G
Sbjct: 2308 KFEASKQNDLGG 2319
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 112 bits (280), Expect = 2e-24
Identities = 101/327 (30%), Positives = 153/327 (46%), Gaps = 46/327 (14%)
Query: 104 ERVAREIVETERAYVRDLRSIVEDYLGPLLDG------GVLGLSVEQVGTLFANIEDIYE 157
E + E+++TE+AYVRDL +E YL + G G+L + +F NI++IY+
Sbjct: 1283 EFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILN----KEHIIFGNIQEIYD 1338
Query: 158 FSSEL-LEDLENSSSAG-GIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALW 215
F + + L++LE + CFV ++ F +Y YC N P S L+ E A +
Sbjct: 1339 FHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILE-----HAGTF 1393
Query: 216 LQERQAQLRHSLP--LQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSM 273
E Q RH L + S+L+KPVQRI KY LLL+EL EG G +++ + M
Sbjct: 1394 FDE--IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE-----LKDGLEVM 1446
Query: 274 TAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGG 333
+V ND H + L+ L GEL+L+ AF+ +G
Sbjct: 1447 LSVPKKANDAM----HVSMLEGFDE--------NLDVQGELILQDAFQVWDPKSLIRKGR 1494
Query: 334 ERLLFLFSRMLLVAKR-----RGLEYTYKGHIFCCNLSVSESPR-DPLGFKVSDLTIPK- 386
ER LFLF L+ +K +Y YK + L V+E DP F + P
Sbjct: 1495 ERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSS 1554
Query: 387 -HRHLLQAKNQEEKRLWIHCLQRLFFE 412
++ +L+A N E K+ WI ++ + E
Sbjct: 1555 DNKTVLKASNIETKQEWIKNIREVIQE 1581
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 107 bits (268), Expect = 6e-23
Identities = 118/401 (29%), Positives = 165/401 (41%), Gaps = 43/401 (10%)
Query: 88 HLSP------VGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLS 141
HL P +G P R V EI+ TER Y++ L+ I E YL + S
Sbjct: 83 HLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDM-FS 141
Query: 142 VEQVGTLFANIEDIYEFSSELLEDLE-----NSSSAGGIAECFVQRSEDFDIYTLYCMNY 196
EQ+ +F NIEDIY F + DLE + I CF++ + F IY+ YC N+
Sbjct: 142 DEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNH 201
Query: 197 PSSLALLRELSLSPPAALWLQE-RQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWA 255
+ L +L + + R Q + + FLL PVQ+I KY L L EL K+ A
Sbjct: 202 LDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTA 261
Query: 256 EGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPE-LSAFGEL 314
+ V A+ M V IN+ KR+ E+ ++ + Q + W G + L EL
Sbjct: 262 Q--DHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSEL 319
Query: 315 VLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAK----RRGLEYTYKGHIFCCNLSV--S 368
+ G P R +R+ FLF +++ K RR + Y YKG I V
Sbjct: 320 IYTGEM--AWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILY-YKGRIDMDKYEVVDI 376
Query: 369 ESPRDPLGFKVSDLTIPK-------HRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAK 421
E RD F VS K HL AK EEK W+ + E K
Sbjct: 377 EDGRDD-DFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFRE---ERKMVQEDEK 432
Query: 422 AKQVLLEN-------SLHCAPKSKPVLEPLTPPLGSPRPRD 455
+ EN ++ PK K V + P P P+D
Sbjct: 433 IGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQD 473
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 106 bits (264), Expect = 2e-22
Identities = 81/253 (32%), Positives = 129/253 (50%), Gaps = 14/253 (5%)
Query: 109 EIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLEN 168
EI ETE Y R L I ++Y+ PL L LS + +F N+ED+ + L ++
Sbjct: 205 EIQETEAKYYRTLEDIEKNYMSPLR----LVLSPADMAAVFINLEDLIKVHHSFLRAIDV 260
Query: 169 SSSAGG--IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLS-PPAALWLQERQAQLRH 225
S GG +A+ F+ E IY YC + + L +L S ++E +++
Sbjct: 261 SVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQD 320
Query: 226 S-LPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMK 284
LQ L+ P+QR+LKYHLLL+EL H AE P R+ ++EA+ +M +A YIN++K
Sbjct: 321 GKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERP---ERQQLKEALEAMQDLAMYINEVK 377
Query: 285 RKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRML 344
R +E ++ E Q + +L FG ++G + + +R LFLF +++
Sbjct: 378 RDKETLRKISEFQSSIEN-LQVKLEEFGRPKIDGELKVRSIVNHTKQ--DRYLFLFDKVV 434
Query: 345 LVAKRRGLEYTYK 357
+V KR+G Y K
Sbjct: 435 IVCKRKGYSYELK 447
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 106 bits (264), Expect = 2e-22
Identities = 81/253 (32%), Positives = 129/253 (50%), Gaps = 14/253 (5%)
Query: 109 EIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLEN 168
EI ETE Y R L I ++Y+ PL L LS + +F N+ED+ + L ++
Sbjct: 200 EIQETEAKYYRTLEDIEKNYMSPLR----LVLSPADMAAVFINLEDLIKVHHSFLRAIDV 255
Query: 169 SSSAGG--IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLS-PPAALWLQERQAQLRH 225
S GG +A+ F+ E IY YC + + L +L S ++E +++
Sbjct: 256 SVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQD 315
Query: 226 S-LPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMK 284
LQ L+ P+QR+LKYHLLL+EL H AE P R+ ++EA+ +M +A YIN++K
Sbjct: 316 GKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERP---ERQQLKEALEAMQDLAMYINEVK 372
Query: 285 RKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRML 344
R +E ++ E Q + +L FG ++G + + +R LFLF +++
Sbjct: 373 RDKETLRKISEFQSSIEN-LQVKLEEFGRPKIDGELKVRSIVNHTKQ--DRYLFLFDKVV 429
Query: 345 LVAKRRGLEYTYK 357
+V KR+G Y K
Sbjct: 430 IVCKRKGYSYELK 442
>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo
sapiens]
Length = 580
Score = 104 bits (260), Expect = 5e-22
Identities = 114/376 (30%), Positives = 174/376 (46%), Gaps = 53/376 (14%)
Query: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSE-LLE 164
V E+VETE+ YV DL IVE Y+ + GV + +F NI+ IYE+ + L+
Sbjct: 164 VLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQ 223
Query: 165 DLENS-SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQL 223
+L+ +A+ F++ +Y +YC N P S ++ E S + +E + QL
Sbjct: 224 ELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS-----YFEELRQQL 278
Query: 224 RHSLPLQSFLLKPVQRILKYHLLLQELGKHW-AEGPGTGGREMVEEAIVSMTAVAWYIND 282
H L L L+KPVQRI+KY LLL++ K++ G T +E+A+ M V ND
Sbjct: 279 GHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTAD---LEQAVEVMCFVPKRCND 335
Query: 283 MKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAF---RGGGGGGPRLRGGERLLFL 339
M RL G+ G +L+A G+L+ + F GG RG ER +FL
Sbjct: 336 MM-----------TLGRLRGFEG-KLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFL 383
Query: 340 FSRMLLVAK------RRGLE--YTYKGHIFCCNLSVSESPR-DPLGFKVSDLTIPK---H 387
F ++++ ++ R G + Y YK I L + + + DP F ++ P+
Sbjct: 384 FEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRG-PEGGIQ 442
Query: 388 RHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVLEPLTPP 447
R++LQA + + WI H A I + L N+L +P E T
Sbjct: 443 RYVLQAADPAISQAWI---------KHVAQILESQRDFL--NALQ-SPIEYQRRESQTNS 490
Query: 448 LGSPRPRDARSFTPGR 463
LG RPR +PGR
Sbjct: 491 LG--RPRGPGVGSPGR 504
>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo
sapiens]
Length = 619
Score = 104 bits (260), Expect = 5e-22
Identities = 114/376 (30%), Positives = 174/376 (46%), Gaps = 53/376 (14%)
Query: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSE-LLE 164
V E+VETE+ YV DL IVE Y+ + GV + +F NI+ IYE+ + L+
Sbjct: 203 VLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQ 262
Query: 165 DLENS-SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQL 223
+L+ +A+ F++ +Y +YC N P S ++ E S + +E + QL
Sbjct: 263 ELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS-----YFEELRQQL 317
Query: 224 RHSLPLQSFLLKPVQRILKYHLLLQELGKHW-AEGPGTGGREMVEEAIVSMTAVAWYIND 282
H L L L+KPVQRI+KY LLL++ K++ G T +E+A+ M V ND
Sbjct: 318 GHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTAD---LEQAVEVMCFVPKRCND 374
Query: 283 MKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAF---RGGGGGGPRLRGGERLLFL 339
M RL G+ G +L+A G+L+ + F GG RG ER +FL
Sbjct: 375 MM-----------TLGRLRGFEG-KLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFL 422
Query: 340 FSRMLLVAK------RRGLE--YTYKGHIFCCNLSVSESPR-DPLGFKVSDLTIPK---H 387
F ++++ ++ R G + Y YK I L + + + DP F ++ P+
Sbjct: 423 FEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRG-PEGGIQ 481
Query: 388 RHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVLEPLTPP 447
R++LQA + + WI H A I + L N+L +P E T
Sbjct: 482 RYVLQAADPAISQAWI---------KHVAQILESQRDFL--NALQ-SPIEYQRRESQTNS 529
Query: 448 LGSPRPRDARSFTPGR 463
LG RPR +PGR
Sbjct: 530 LG--RPRGPGVGSPGR 543
Score = 30.8 bits (68), Expect = 9.4
Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 12/110 (10%)
Query: 1228 PTPVQTTMVLSKPGGSLASHVARLESSDLTPPHSP------PPSSRQLLGPNAAALSRYL 1281
P P +T +L GG L + L + P SP P S + G + +
Sbjct: 7 PAPGRTDRILGVMGGMLRA--CALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDREHEV 64
Query: 1282 AASYI---SQSLARRQGPGGGAPAASRGSWSSAPTSRASSPPPQPQPPPP 1328
A + S S+A +G A AAS + S P+S SS P P PP P
Sbjct: 65 LAGALQPESYSIAGSEG-SISASAASGLAAPSGPSSGLSSGPCSPGPPGP 113
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 94.4 bits (233), Expect = 7e-19
Identities = 113/432 (26%), Positives = 189/432 (43%), Gaps = 62/432 (14%)
Query: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSEL-LE 164
V E+V+TE+ YV+DL +VE ++ + + GV + +F NI IY++ + L
Sbjct: 236 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLA 295
Query: 165 DLENS-SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQL 223
+LE +A+ F++ IY YC N P S ++ E + +E + ++
Sbjct: 296 ELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDA------YFEEVKQEI 349
Query: 224 RHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDM 283
L L FL+KP+QRI KY LLL++ ++E G + +E+A+ M V NDM
Sbjct: 350 NQRLTLSDFLIKPIQRITKYQLLLKDF-LRYSEKAGLECSD-IEKAVELMCLVPKRCNDM 407
Query: 284 KRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRG-GGGGGPRLRGGERLLFLFSR 342
RL G+ G L+A G+L+ + F G + R ER +FLF +
Sbjct: 408 MN-----------LGRLQGFEG-TLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQ 455
Query: 343 MLLVAK--RRGL---EYTYKGHIFCCNLSVSES-PRDPLGFKVSDLTIPKHRHLLQAKNQ 396
+++ ++ R+G Y +K I L + E+ DP F + + R +LQA N
Sbjct: 456 IVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRE-TSERVVLQAANA 514
Query: 397 EEKRLWIHCL------QRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVL--EPLTPPL 448
+ ++ W+ + QR F + I + K+ +S V+ +P P
Sbjct: 515 DIQQAWVQDINQVLETQRDFLNALQSPIEYQRKE-----------RSTAVMRSQPARLPQ 563
Query: 449 GSPRPRDARSFTPGRRNTAPSPGPSVIRRGRRQSEPVKDPYVMFPQNAKPGFKHAGSEGE 508
SPRP S P P +G + P+ P + N PGF++ G+
Sbjct: 564 ASPRP---YSSVPAGSEKPP--------KGSSYNPPL-PPLKISTSNGSPGFEY-HQPGD 610
Query: 509 LYPPESQPPVSG 520
+ Q + G
Sbjct: 611 KFEASKQNDLGG 622
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 94.4 bits (233), Expect = 7e-19
Identities = 81/280 (28%), Positives = 126/280 (45%), Gaps = 31/280 (11%)
Query: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVL----GLSVEQVGTLFANIEDIYEFSSE 161
V E+ +TER YV L +V +L + ++ E V LF+NIEDI E
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 162 LLEDLENS-----SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWL 216
L+ +E ++ + CF+ + F IY YC N+ + LL EL+ +L
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFL 146
Query: 217 QERQ---AQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSM 273
+ +PL+ +L+ P+QRI KY L+L+EL K M EA+ +M
Sbjct: 147 LNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVM--EALQAM 204
Query: 274 TAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELS-AFGELVLEGAFRGGGGGGPRLRG 332
AV IN+ KR+ E L+E Q + GW G ++ E+++ G G +
Sbjct: 205 KAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQ--- 261
Query: 333 GERLLFLFSRMLLVAKRR------------GLEYTYKGHI 360
ER+ FLF +L+ KR+ G Y ++G I
Sbjct: 262 -ERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI 300
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 94.4 bits (233), Expect = 7e-19
Identities = 81/280 (28%), Positives = 126/280 (45%), Gaps = 31/280 (11%)
Query: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVL----GLSVEQVGTLFANIEDIYEFSSE 161
V E+ +TER YV L +V +L + ++ E V LF+NIEDI E
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 162 LLEDLENS-----SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWL 216
L+ +E ++ + CF+ + F IY YC N+ + LL EL+ +L
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFL 146
Query: 217 QERQ---AQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSM 273
+ +PL+ +L+ P+QRI KY L+L+EL K M EA+ +M
Sbjct: 147 LNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVM--EALQAM 204
Query: 274 TAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELS-AFGELVLEGAFRGGGGGGPRLRG 332
AV IN+ KR+ E L+E Q + GW G ++ E+++ G G +
Sbjct: 205 KAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQ--- 261
Query: 333 GERLLFLFSRMLLVAKRR------------GLEYTYKGHI 360
ER+ FLF +L+ KR+ G Y ++G I
Sbjct: 262 -ERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI 300
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
Length = 626
Score = 93.6 bits (231), Expect = 1e-18
Identities = 67/225 (29%), Positives = 111/225 (49%), Gaps = 29/225 (12%)
Query: 81 PGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGL 140
P P+ HLS RL +V +E+V+TE++YV+DL + E YL PL + L
Sbjct: 11 PPRPLARHLSDA--------DRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL-- 60
Query: 141 SVEQVGTLFANIEDIYEFSSELLEDLENSSSAGG-----------------IAECFVQRS 183
+ +++ +LF ++ ++ EF LE LE+ SA + F+ +
Sbjct: 61 TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA 120
Query: 184 EDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKY 243
+ F +Y+ +C N+ +L +L R +HS L+S+L+KPVQR+LKY
Sbjct: 121 DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKY 180
Query: 244 HLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQE 288
LLL+EL + + EA+ +M VA +IN+M++ E
Sbjct: 181 PLLLKELVS--LTDQESEEHYHLTEALKAMEKVASHINEMQKIYE 223
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 93.6 bits (231), Expect = 1e-18
Identities = 67/225 (29%), Positives = 111/225 (49%), Gaps = 29/225 (12%)
Query: 81 PGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGL 140
P P+ HLS RL +V +E+V+TE++YV+DL + E YL PL + L
Sbjct: 1086 PPRPLARHLSDA--------DRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL-- 1135
Query: 141 SVEQVGTLFANIEDIYEFSSELLEDLENSSSAGG-----------------IAECFVQRS 183
+ +++ +LF ++ ++ EF LE LE+ SA + F+ +
Sbjct: 1136 TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA 1195
Query: 184 EDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKY 243
+ F +Y+ +C N+ +L +L R +HS L+S+L+KPVQR+LKY
Sbjct: 1196 DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKY 1255
Query: 244 HLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQE 288
LLL+EL + + EA+ +M VA +IN+M++ E
Sbjct: 1256 PLLLKELVS--LTDQESEEHYHLTEALKAMEKVASHINEMQKIYE 1298
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 92.0 bits (227), Expect = 3e-18
Identities = 118/444 (26%), Positives = 191/444 (43%), Gaps = 44/444 (9%)
Query: 33 ETRTAPAAPTMASPRGSGSSTSLSTVGSEGDPAP----GPTPACSASRPEPLPGPPIRLH 88
ET TAPA+PT S G+ S +S T G G P G E P
Sbjct: 134 ETATAPASPTTDSCDGNASDSSYRTPGI-GPVLPLEERGAETETKVQERENGESPLELEQ 192
Query: 89 LSPVGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLG-LSVEQVGT 147
L +L ++A E++ TERAYV L + + + LL+ G E V
Sbjct: 193 LDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNK 252
Query: 148 LFANIEDIYEFSSE-LLEDLENS----SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLAL 202
+F+NI I F S+ LL +LE + I + + + +Y Y + +++ L
Sbjct: 253 IFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMEL 312
Query: 203 LRELSLSPPAALWLQE--RQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGT 260
++ ++ P + E ++ ++ SL LQ +L+PVQRI +Y +LL++ + P +
Sbjct: 313 VKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLP--PDS 370
Query: 261 GGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAF 320
++++ ++ A + N RK E+ +L E+ LG ++ EL+ EG
Sbjct: 371 LDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGE-EEDIVNPSNELIKEGQI 429
Query: 321 RGGGGGGPRLRGGERLLFLFSRMLLVAKRR----GLEYTYKGHIFCCNLSVSESPRD--P 374
+ ER LFLF+ MLL + G ++T + + + + E+ + P
Sbjct: 430 LKLAARNTSAQ--ERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYP 487
Query: 375 LGFKVSDLTIPKHRHL-LQAKNQEEKRLWIHCLQR---LFFENHPASIPAKAKQVLLENS 430
F+VS K R L LQA + ++K WI LQ F + H A AK +N
Sbjct: 488 HTFQVSG----KERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAK----DND 539
Query: 431 LHCAPKSKPVLEPLTPPLGSPRPR 454
+H E T LG PR
Sbjct: 540 IHS--------EVSTAELGKRAPR 555
>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
sapiens]
Length = 1114
Score = 91.3 bits (225), Expect = 6e-18
Identities = 93/356 (26%), Positives = 158/356 (44%), Gaps = 54/356 (15%)
Query: 96 GSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPL----LDGGVLGLSVEQVGTLFAN 151
G P R R+ R+++ETE Y+++++SI++ Y+ P+ L + + LF N
Sbjct: 615 GDLSPRR--RIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGN 672
Query: 152 IEDIYEFSSE-LLEDLEN-SSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLS 209
I ++YEF + L++LE + + +A CF++R ED IY Y N P + A+ +E
Sbjct: 673 IRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQ-- 730
Query: 210 PPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQ----------------ELGKH 253
+ Q QL H+LPL +L P QR++KY +LL+ ELG
Sbjct: 731 --DCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGS 788
Query: 254 WAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGE 313
+GP + AV I D+ + E A L V ++ G+
Sbjct: 789 AKDGPKRTKDSAFSTELQQALAV---IEDLIKSCELAVDLAAVTE-----CPDDIGKLGK 840
Query: 314 LVLEGAF--------RGGGGGGPRLRGGERLLFLFSRMLLVAKRR------GL--EYTYK 357
L+L G F R R + +R ++LF R ++ K R GL Y++K
Sbjct: 841 LLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK 900
Query: 358 GHIFCCNLSVSESPR-DPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFE 412
+ LS+ + R F+++ +++LQA ++E + W + +L E
Sbjct: 901 KTMKLMTLSIRQLGRGSHRKFEIASRN-GLEKYILQAASKEIRDCWFSEISKLLME 955
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 90.5 bits (223), Expect = 1e-17
Identities = 86/324 (26%), Positives = 143/324 (44%), Gaps = 21/324 (6%)
Query: 108 REIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLE 167
REI +TE Y L SI + +L PL L + + +F NIED+ + L++++
Sbjct: 200 REIQQTEEKYTDTLGSIQQHFLKPLQRF----LKPQDIEIIFINIEDLLRVHTHFLKEMK 255
Query: 168 NSSSAGGIA---ECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLR 224
+ G A + F++ E F +Y YC S+ L ++ + E +Q
Sbjct: 256 EALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRA 315
Query: 225 HS--LPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYIND 282
++ L+ L+ P+QR+LKYHLLLQEL KH E +E + A+ +M +A +N+
Sbjct: 316 NNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAM---EKENLRLALDAMRDLAQCVNE 372
Query: 283 MKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSR 342
+KR E ++ Q + L+ +G ++G + R +R FL +
Sbjct: 373 VKRDNETLRQITNFQLSIEN-LDQSLAHYGRPKIDGELK--ITSVERRSKMDRYAFLLDK 429
Query: 343 MLLVAKRRGLEYTYKGHIFCCNLSV---SESPRDPLGFKVSDLTIP---KHRHLLQAKNQ 396
LL+ KRRG Y K + + V S RD + L I + L K +
Sbjct: 430 ALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTR 489
Query: 397 EEKRLWIHCLQRLFFENHPASIPA 420
E K+ W+ + +P + A
Sbjct: 490 ELKKKWMEQFEMAISNIYPENATA 513
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 89.7 bits (221), Expect = 2e-17
Identities = 90/353 (25%), Positives = 158/353 (44%), Gaps = 25/353 (7%)
Query: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLED 165
V + I++TE+ Y ++L+S++ YL PL LS +V +L N E++ F L +
Sbjct: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQSNN--NLSTVEVTSLLGNFEEVCTFQQTLCQA 302
Query: 166 LENSS----SAGGIAECFVQRSEDF-DIYTLYCMNYPSSLALLRELSLSPPAALWLQERQ 220
LE S + + C + F +Y YC N+PS++ +L + S +++ +
Sbjct: 303 LEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHS--DELEQFMENQG 360
Query: 221 AQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYI 280
A L L + L KP R+ KY LLQEL +H + + + +AIV+ +
Sbjct: 361 ASSPGILILTTNLSKPFMRLEKYVTLLQELERHMED--THPDHQDILKAIVAFKTLMGQC 418
Query: 281 NDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLF 340
D++++++ LQ + + W G ++ G ++ G ER L LF
Sbjct: 419 QDLRKRKQ--LELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKE--ERYLMLF 474
Query: 341 SRMLLV--AKRRGLEYTYKGHIFCCNLSVS---ESPRDPLGFKVSDLTIPKHRHLLQAKN 395
S +L++ A R + Y+G I V+ E + F+++ T+ R ++ N
Sbjct: 475 SNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTV--ERIVVHCNN 532
Query: 396 QEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSK-PVLEPLTPP 447
++ + W+ L RL PAS + +K S H + S PL PP
Sbjct: 533 NQDFQEWLEQLNRLI--RGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPP 583
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 87.4 bits (215), Expect = 8e-17
Identities = 75/274 (27%), Positives = 128/274 (46%), Gaps = 27/274 (9%)
Query: 109 EIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLEN 168
EI +TE Y L SI + ++ PL L+ + ++F NI ++ + L++++ +
Sbjct: 199 EIKQTEEKYTETLESIEKYFMAPLKRF----LTAAEFDSVFINIPELVKLHRNLMQEIHD 254
Query: 169 S---SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPP-AALWLQERQAQLR 224
S + + + F+ E IY YC S+++ L +S + L L+E +
Sbjct: 255 SIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRAN 314
Query: 225 HS-LPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDM 283
+ L+ L+ P+QR+LKYHLLLQEL KH + ++ A+ +M +A Y+N++
Sbjct: 315 NGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKL---ALDAMKDLAQYVNEV 371
Query: 284 KRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRL------RGGERLL 337
KR E +++ Q + P L FG R G G R+ ER +
Sbjct: 372 KRDNETLREIKQFQLSIENLNQPVL-LFG--------RPQGDGEIRITTLDKHTKQERHI 422
Query: 338 FLFSRMLLVAKRRGLEYTYKGHIFCCNLSVSESP 371
FLF ++V KR+G Y K I ++ +P
Sbjct: 423 FLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNP 456
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 86.7 bits (213), Expect = 1e-16
Identities = 62/207 (29%), Positives = 105/207 (50%), Gaps = 27/207 (13%)
Query: 102 RLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSE 161
+L +V E++ETER YV+DL ++E YL PL L + +++ LF N+ ++ EF E
Sbjct: 1040 KLRKVICELLETERTYVKDLNCLMERYLKPLQKETFL--TQDELDVLFGNLTEMVEFQVE 1097
Query: 162 LLEDLENSS--------------------SAGGIAECFVQRSEDFDIYTLYCMNYPSSLA 201
L+ LE+ S GG F+ ++ F +Y+ +C ++
Sbjct: 1098 FLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGG---SFLYYADRFKLYSAFCASHTKVPK 1154
Query: 202 LLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTG 261
+L + +L + + +HS L+S+L+KP+QRILKY LLL+EL +
Sbjct: 1155 VLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLREL--FALTDAESE 1212
Query: 262 GREMVEEAIVSMTAVAWYINDMKRKQE 288
++ AI +M VA +IN+M++ E
Sbjct: 1213 EHYHLDVAIKTMNKVASHINEMQKIHE 1239
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.133 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,376,167
Number of Sequences: 37866
Number of extensions: 4887307
Number of successful extensions: 40194
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 288
Number of HSP's successfully gapped in prelim test: 1245
Number of HSP's that attempted gapping in prelim test: 26951
Number of HSP's gapped (non-prelim): 12008
length of query: 1386
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1271
effective length of database: 13,892,928
effective search space: 17657911488
effective search space used: 17657911488
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.