Search of human proteins with 16306489

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
         (785 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]          1558   0.0  
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]          1558   0.0  
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]          974   0.0  
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]           965   0.0  
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]          957   0.0  
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]           956   0.0  
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]            953   0.0  
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]           934   0.0  
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]          926   0.0  
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]          921   0.0  
gi|16753221 cadherin 22 precursor [Homo sapiens]                      866   0.0  
gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens]          776   0.0  
gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]                 751   0.0  
gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens]                 733   0.0  
gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens]          513   e-145
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]           446   e-125
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]           439   e-123
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]            405   e-113
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]           381   e-105
gi|4826669 cadherin 15 preproprotein [Homo sapiens]                   372   e-103
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]   275   1e-73
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi...   275   1e-73
gi|4502719 cadherin 13 preproprotein [Homo sapiens]                   267   3e-71
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap...   261   1e-69
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap...   261   1e-69
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi...   260   3e-69
gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo sapi...   260   3e-69
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]           245   1e-64
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]            228   1e-59
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]            216   7e-56

>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
          Length = 785

 Score = 1558 bits (4034), Expect = 0.0
 Identities = 785/785 (100%), Positives = 785/785 (100%)

Query: 1   MKLGKVEFCHFLQLIALFLCFSGMSQAELSRSRSKPYFQSGRSRTKRSWVWNQFFVLEEY 60
           MKLGKVEFCHFLQLIALFLCFSGMSQAELSRSRSKPYFQSGRSRTKRSWVWNQFFVLEEY
Sbjct: 1   MKLGKVEFCHFLQLIALFLCFSGMSQAELSRSRSKPYFQSGRSRTKRSWVWNQFFVLEEY 60

Query: 61  MGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTL 120
           MGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTL
Sbjct: 61  MGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTL 120

Query: 121 RAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDA 180
           RAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDA
Sbjct: 121 RAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDA 180

Query: 181 DDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNG 240
           DDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNG
Sbjct: 181 DDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNG 240

Query: 241 GLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYK 300
           GLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYK
Sbjct: 241 GLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYK 300

Query: 301 IVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSD 360
           IVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSD
Sbjct: 301 IVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSD 360

Query: 361 TTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTD 420
           TTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTD
Sbjct: 361 TTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTD 420

Query: 421 LERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAP 480
           LERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAP
Sbjct: 421 LERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAP 480

Query: 481 EFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNT 540
           EFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNT
Sbjct: 481 EFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNT 540

Query: 541 ASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYV 600
           ASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYV
Sbjct: 541 ASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYV 600

Query: 601 LPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGE 660
           LPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGE
Sbjct: 601 LPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGE 660

Query: 661 EDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADV 720
           EDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADV
Sbjct: 661 EDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADV 720

Query: 721 DPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQ 780
           DPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQ
Sbjct: 721 DPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQ 780

Query: 781 ESLYS 785
           ESLYS
Sbjct: 781 ESLYS 785


>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
          Length = 785

 Score = 1558 bits (4034), Expect = 0.0
 Identities = 785/785 (100%), Positives = 785/785 (100%)

Query: 1   MKLGKVEFCHFLQLIALFLCFSGMSQAELSRSRSKPYFQSGRSRTKRSWVWNQFFVLEEY 60
           MKLGKVEFCHFLQLIALFLCFSGMSQAELSRSRSKPYFQSGRSRTKRSWVWNQFFVLEEY
Sbjct: 1   MKLGKVEFCHFLQLIALFLCFSGMSQAELSRSRSKPYFQSGRSRTKRSWVWNQFFVLEEY 60

Query: 61  MGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTL 120
           MGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTL
Sbjct: 61  MGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTL 120

Query: 121 RAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDA 180
           RAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDA
Sbjct: 121 RAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDA 180

Query: 181 DDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNG 240
           DDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNG
Sbjct: 181 DDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNG 240

Query: 241 GLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYK 300
           GLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYK
Sbjct: 241 GLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYK 300

Query: 301 IVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSD 360
           IVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSD
Sbjct: 301 IVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSD 360

Query: 361 TTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTD 420
           TTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTD
Sbjct: 361 TTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTD 420

Query: 421 LERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAP 480
           LERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAP
Sbjct: 421 LERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAP 480

Query: 481 EFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNT 540
           EFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNT
Sbjct: 481 EFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNT 540

Query: 541 ASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYV 600
           ASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYV
Sbjct: 541 ASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYV 600

Query: 601 LPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGE 660
           LPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGE
Sbjct: 601 LPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGE 660

Query: 661 EDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADV 720
           EDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADV
Sbjct: 661 EDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADV 720

Query: 721 DPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQ 780
           DPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQ
Sbjct: 721 DPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQ 780

Query: 781 ESLYS 785
           ESLYS
Sbjct: 781 ESLYS 785


>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
          Length = 801

 Score =  974 bits (2518), Expect = 0.0
 Identities = 491/777 (63%), Positives = 596/777 (76%), Gaps = 7/777 (0%)

Query: 8   FCHFLQLIALFLCFSGMSQAELSRSRS-KPYFQSGRSRTKRSWVWNQFFVLEEYMGSDPL 66
           F   + L    L  +   Q EL    S KP       RTKRSWVWNQFFVLEEY G+DPL
Sbjct: 22  FWGLMDLTTTVLSDTPTPQGELEALLSDKP---QSHQRTKRSWVWNQFFVLEEYTGTDPL 78

Query: 67  YVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALD 126
           YVGKLHSD+D+GDGSIKYILSGEGA  +F ID+ TGDIHA +RLDREE+A YTLRAQALD
Sbjct: 79  YVGKLHSDMDRGDGSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALD 138

Query: 127 RLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYG 186
           R T +P+EPESEF+IKIQDINDNEPKFLDGPY A VPEMSPVGTSV+QVTATDADDPTYG
Sbjct: 139 RRTGRPMEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYG 198

Query: 187 NSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTT 246
           NSARVVYSILQGQPYFSV+ KTGVI+TAL NMDREAK+ Y ++IQAKDM GQ GGL+GTT
Sbjct: 199 NSARVVYSILQGQPYFSVDSKTGVIRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTT 258

Query: 247 SVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDG 306
           +V +TL+DVNDNPPRFP++ YQ +V ES P++S V R+ A D D G NAEM+Y IVDGDG
Sbjct: 259 TVNITLSDVNDNPPRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDG 318

Query: 307 LGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKI 366
              F IS D   Q GIIT++K L FE+K SYTL++E AN   + RFL+LGPF DTTTV I
Sbjct: 319 ADAFDISTDPNFQVGIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHI 378

Query: 367 IVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFN 426
            VEDVDEPPVF    Y +EV E   +G  I  ++A DPD +N+ +RYSIDR++D  R+F 
Sbjct: 379 SVEDVDEPPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDRSSDPGRFFY 438

Query: 427 IDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDY 486
           +D  +G + TA+ LDRE  + HNITVLAME  NPSQVG   V I +LD+NDNAPEF   Y
Sbjct: 439 VDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFY 498

Query: 487 ETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTR 546
           E  VCENA+ GQ+IQ +SAVD+D+P NG  FY+SL  +A NN NF+++DN+DNTA ILTR
Sbjct: 499 EAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDNTARILTR 558

Query: 547 RNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLS 606
           R+GFR+QEQSV++LPI I DSG P LSST TLTI+VC CD DG   +C+ EAY+LP  LS
Sbjct: 559 RSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDDGHVMSCSPEAYMLPVSLS 618

Query: 607 TGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGEEDTEAF 666
            GALIAILAC+  LLVL+LLI++MRR +K+P I D+E +I ENIVRYDDEGGGEEDTEAF
Sbjct: 619 RGALIAILACIFVLLVLVLLILSMRRHRKQPYIIDDEENIHENIVRYDDEGGGEEDTEAF 678

Query: 667 DMAAL---RNLNVIRDTKTRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADVDPG 723
           D+AA+   R        KTR+D+ PEI+ LSR   ++   N     ++  +L EAD+D  
Sbjct: 679 DIAAMWNPREAQAGAAPKTRQDMLPEIESLSRYVPQTCAVNSTVHSYVLAKLYEADMDLW 738

Query: 724 APPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQ 780
           APP+DSLQTY FEG+GSVA SLSSL S +S+S+Q++D+L+DWGPRF++LA++YG  +
Sbjct: 739 APPFDSLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAELYGASE 795


>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
          Length = 799

 Score =  965 bits (2495), Expect = 0.0
 Identities = 463/738 (62%), Positives = 581/738 (78%)

Query: 43  SRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTG 102
           +R+KR WVWNQ FVLEE+ G +P+ VG+LH+D+D G   IKYILSG+GA +IF I++ TG
Sbjct: 57  NRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTG 116

Query: 103 DIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGV 162
           DIHA KRLDREE+A YTL AQA+D  T+KP+EP SEF+IK+QDINDN P+FL+GPY A V
Sbjct: 117 DIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATV 176

Query: 163 PEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREA 222
           PEMS +GTSV  VTATDADDP YGNSA++VYSIL+GQPYFS+EP+T +IKTALPNMDREA
Sbjct: 177 PEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREA 236

Query: 223 KDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVA 282
           K++YL+VIQAKDM G +GGLSGTT++TVTLTDVNDNPP+F +  Y ++VPE + + + + 
Sbjct: 237 KEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIG 296

Query: 283 RIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIE 342
           R+KA D DIG NA+  Y I+DGDG  +F+I+ D + Q+GII ++K LDFE K SYTL++E
Sbjct: 297 RVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVE 356

Query: 343 AANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAH 402
           AAN   DPRF   GPF DT TVKI+VED DEPPVFSSP Y +EV E   + ++IG V A 
Sbjct: 357 AANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTAR 416

Query: 403 DPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQ 462
           DPD ++SP+R+SIDR+TDLER FNI+A+ G IT A  LDRE +  HNIT++A E +N SQ
Sbjct: 417 DPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQ 476

Query: 463 VGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLT 522
           + R  VAI +LD+NDNAPEFA +YE  +CEN +PGQVIQ +SA+DKD+P NGH F +SL 
Sbjct: 477 ISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLL 536

Query: 523 TDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRV 582
            +  NN NF++K N+DN+ SIL + NGF RQ+Q VY LPI I DSG+P LSST+TLTIRV
Sbjct: 537 PEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596

Query: 583 CDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDE 642
           C C  DGV Q+CN EAYVLP GLS GALIAILAC++ LLV+++L VT+RR K EPLI  +
Sbjct: 597 CGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKD 656

Query: 643 ERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIP 702
           + D+RENI+RYDDEGGGEEDTEAFD+A L+N + I     R+D+ P++QF+ R     +P
Sbjct: 657 DEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVP 716

Query: 703 DNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYL 762
           + V   EFI  RL EAD DP APPYDS+Q Y +EG GSVA SLSSL+S +S+SDQN+DYL
Sbjct: 717 NGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYL 776

Query: 763 SDWGPRFKRLADMYGTGQ 780
           SDWGPRFKRL ++Y  G+
Sbjct: 777 SDWGPRFKRLGELYSVGE 794


>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
          Length = 788

 Score =  957 bits (2474), Expect = 0.0
 Identities = 476/738 (64%), Positives = 583/738 (78%), Gaps = 6/738 (0%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGD 103
           R KR W+WNQFF+LEEY GSD  YVGKLHSD DKGDGS+KYILSG+GA ++FIIDE TGD
Sbjct: 51  RQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTLFIIDEKTGD 110

Query: 104 IHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVP 163
           IHAT+R+DREE+A+YTLRAQA++R T +PVEPESEFVIKI DINDNEP F +  YTA VP
Sbjct: 111 IHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVP 170

Query: 164 EMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAK 223
           EMS VGTSVVQVTATDADDP+YGNSARV+YSILQGQPYFSVEP+TG+I+TALPNM+RE +
Sbjct: 171 EMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGIIRTALPNMNRENR 230

Query: 224 DQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVAR 283
           +QY +VIQAKDM GQ GGLSGTT+V +TLTDVNDNPPRFP+ +    V ES PV + +  
Sbjct: 231 EQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAIGS 290

Query: 284 IKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEA 343
           +KA DAD G NAE+EY+I+DGDG  +F I  +K+TQEGIIT++K LD+E++  YTL++EA
Sbjct: 291 VKATDADTGKNAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEA 350

Query: 344 ANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHD 403
            N   DPRF  LGPF DTT VKI +EDVDEPPVFS   Y  EV E  +VG IIGTV A D
Sbjct: 351 ENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARD 410

Query: 404 PDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQV 463
           PDS +SP+R+S+DR+TDL+R FNI + +G + T+K LDRE +  HN+TV+A E  NP + 
Sbjct: 411 PDSISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINNPKET 470

Query: 464 GRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTT 523
            R  V + ILD+NDNAP+FA+ Y+T VCENA+PGQ+IQ ISAVDKD+P  G +F+FSL  
Sbjct: 471 TRVAVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSL-- 528

Query: 524 DATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVC 583
            A  N NF+++DN+DNTA ILTR+NGF R E S Y LP+ I D+  P  SST TLTIRVC
Sbjct: 529 -AAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVC 587

Query: 584 DCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRR-RKKEPLIFDE 642
            CD+ G  Q+C+AEA +LPAGLSTGALIAIL C++ LLV+++L   ++R RKKEPLI  +
Sbjct: 588 ACDSQGNMQSCSAEALLLPAGLSTGALIAILLCIIILLVIVVLFAALKRQRKKEPLILSK 647

Query: 643 ERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIP 702
           E DIR+NIV Y+DEGGGEEDT+AFD+  LRN   I + K RRD+ PE  F+ R    + P
Sbjct: 648 E-DIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIEEKKLRRDIIPETLFIPRRT-PTAP 705

Query: 703 DNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYL 762
           DN   R+FI ERLKE D+DP APPYDSL TYA+EGN S+AESLSSL+S ++  DQNYDYL
Sbjct: 706 DNTDVRDFINERLKEHDLDPTAPPYDSLATYAYEGNDSIAESLSSLESGTTEGDQNYDYL 765

Query: 763 SDWGPRFKRLADMYGTGQ 780
            +WGPRF +LA+MYG G+
Sbjct: 766 REWGPRFNKLAEMYGGGE 783


>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
          Length = 790

 Score =  956 bits (2471), Expect = 0.0
 Identities = 473/734 (64%), Positives = 571/734 (77%), Gaps = 1/734 (0%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGD 103
           R KR WVWNQFFVLEE+MG DP YVGKLHS+ DKGDGS+KYIL+GEGA +IFIID+ TGD
Sbjct: 50  RPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGTIFIIDDTTGD 109

Query: 104 IHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVP 163
           IH+TK LDRE++ +Y L AQA+DR TNKP+EPESEF+IK+QDINDN PKF DGPY   VP
Sbjct: 110 IHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVP 169

Query: 164 EMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAK 223
           EMS +GTSV+QVTATDADDPTYGNSARVVYSILQGQPYFSV+PKTGVI+TAL NMDREA+
Sbjct: 170 EMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDREAR 229

Query: 224 DQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVAR 283
           + Y +VIQAKDM GQ GGLSG+T+V +TLTDVNDNPPRFP++ YQ  VPES  V S V +
Sbjct: 230 EHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQVGSAVGK 289

Query: 284 IKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEA 343
           IKA DAD G+NA+M Y I++GDG+GIF IS DKET+EGI++++K L++E K SYTL IE 
Sbjct: 290 IKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEG 349

Query: 344 ANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHD 403
           AN   D RF  LGPF D T +KIIV DVDEPP+FS P Y MEV E  ++G ++GTV A D
Sbjct: 350 ANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQD 409

Query: 404 PDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQV 463
           PDS+NS VRY I+ N + +R+FNIDAN+G I T K LDRE    +NITV A E  NP  +
Sbjct: 410 PDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDLL 469

Query: 464 GRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTT 523
               V I +LD+NDN PE A +Y+  VCEN++PGQVI  ISA DKD+ +NG +F F L  
Sbjct: 470 SHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDE 529

Query: 524 DATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVC 583
               N NF+LKDN+DNTASILTRR  F R  Q VYYLPI I D G PSLSS++TLTIRVC
Sbjct: 530 RLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVC 589

Query: 584 DCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEE 643
            C+ DG  +TC+AEA++  AGLSTGALIAIL CVL LL +++L +T+RR KKEPLI  EE
Sbjct: 590 ACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSKKEPLIISEE 649

Query: 644 RDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIPD 703
            D+REN+V YDDEGGGEEDTEAFD+ ALRN +   + K RRD+ PE++   R    S  +
Sbjct: 650 -DVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLE 708

Query: 704 NVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLS 763
           ++  +EFI +RL EAD+DP  PPYDSLQTYA+EG  S A S+SSLDS ++ SDQ+Y YL 
Sbjct: 709 SIDVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQDYHYLG 768

Query: 764 DWGPRFKRLADMYG 777
           DWGP FK+LA++YG
Sbjct: 769 DWGPEFKKLAELYG 782


>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
          Length = 790

 Score =  953 bits (2463), Expect = 0.0
 Identities = 471/736 (63%), Positives = 578/736 (78%), Gaps = 3/736 (0%)

Query: 43  SRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTG 102
           +R+KRSW+WNQFF+LEEY GSD  YVGKLHSD D+GDGS+KYILSG+GA  +FII+ENTG
Sbjct: 49  NRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTG 108

Query: 103 DIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGV 162
           DI ATKRLDREE+  Y LRAQA++R T +PVEPESEF+IKI DINDNEP F    YTA V
Sbjct: 109 DIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATV 168

Query: 163 PEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREA 222
           PEMS VGT VVQVTATDADDPTYGNSA+VVYSILQGQPYFSVE +TG+IKTAL NMDRE 
Sbjct: 169 PEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDREN 228

Query: 223 KDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVA 282
           ++QY +VIQAKDM GQ GGLSGTT+V +TLTDVNDNPPRFP+ +YQ+  PES P  + + 
Sbjct: 229 REQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIG 288

Query: 283 RIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIE 342
           RIKA+DAD+G NAE+EY I DG+GL +F +  D+ETQEGIIT++K LDFE K  YTL++E
Sbjct: 289 RIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVE 348

Query: 343 AANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAH 402
           A+N   +PRFL LGPF D+ TV+I+VEDVDEPPVFS   Y +++ E  Q+   IG+V A 
Sbjct: 349 ASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQ 408

Query: 403 DPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQ 462
           DPD++ +PV+YS+DR+TD++R FNID+ +G I T+K LDRET   HNITV+A E  NP Q
Sbjct: 409 DPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQ 468

Query: 463 VGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLT 522
             R  + I +LD+NDNAPEFA  YET VCE A+  Q+IQ + AVDKD+P +GHQF FSL 
Sbjct: 469 SSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLA 528

Query: 523 TDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRV 582
            +A +  NF+++DNKDNTA ILTR+NG+ R E S Y LP+ I D+  P  SST T+T+RV
Sbjct: 529 PEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588

Query: 583 CDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRR-RKKEPLIFD 641
           C CD  G  Q+C+AEA + P GLSTGAL+AIL C++ LLV ++L   +RR RKKEPLI  
Sbjct: 589 CACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIIS 648

Query: 642 EERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSI 701
           +E DIR+NIV Y+DEGGGEEDT+AFD+  LRN   I D K RRD+ PE  FL R    + 
Sbjct: 649 KE-DIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRT-PTA 706

Query: 702 PDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDY 761
            DN   R+FI +RLKE D DP APPYDSL TYA+EG GSVA+SLSSL+S+++++DQ+YDY
Sbjct: 707 RDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDY 766

Query: 762 LSDWGPRFKRLADMYG 777
           LSDWGPRFK+LADMYG
Sbjct: 767 LSDWGPRFKKLADMYG 782


>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
          Length = 789

 Score =  934 bits (2414), Expect = 0.0
 Identities = 458/737 (62%), Positives = 577/737 (78%), Gaps = 7/737 (0%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGD 103
           RTKR W+WNQFF+LEEY G+D  YVGKLH+D DKGDG++KYIL+G+GA S+F+IDENTGD
Sbjct: 50  RTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGSLFVIDENTGD 109

Query: 104 IHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVP 163
           IHA K+LDREE++ Y LRA+A+DR T + VEPESEF+IKI DINDNEPKF    YTA VP
Sbjct: 110 IHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVP 169

Query: 164 EMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAK 223
           EMS VGTSV+QVTATDADD  YGNSA+VVYSILQGQPYFSV+P++G+IKTALP+M RE +
Sbjct: 170 EMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSRENR 229

Query: 224 DQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVAR 283
           +QY +VIQAKDM GQ GGLSGTT+V +TLTDVN+NPPRFP+ +YQ+N PES+P+ + + R
Sbjct: 230 EQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPESVPLGTHLGR 289

Query: 284 IKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEA 343
           IKA D D+G NAEMEY I +GDG  +F +  DK+TQEGIIT+++ LDFE +  YTLR++A
Sbjct: 290 IKANDPDVGENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQMLYTLRVDA 349

Query: 344 ANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHD 403
           +N   DPRFL LGPF DT  VKI VED+DEPPVF+   Y +EV E  + G+IIG V A+D
Sbjct: 350 SNTHPDPRFLHLGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQVTAYD 409

Query: 404 PDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQV 463
           PD+ N+ ++YS+DR+TD++R F I + +G I T K+LDRE++  HNITV A E  NP Q 
Sbjct: 410 PDARNNLIKYSVDRHTDMDRIFGIHSENGSIFTLKALDRESSPWHNITVTATEINNPKQS 469

Query: 464 GRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTT 523
               V I ILDIND+APEFAM YET VCENA+PGQ+IQ +S +DKD+P  GH+F+F    
Sbjct: 470 SHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQTVSVMDKDDPPRGHKFFFEPVP 529

Query: 524 DATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVC 583
           + T N NF++ DNKDNTA I+TR++G+ R + S Y LPI I D+  P  SST TLTIRVC
Sbjct: 530 EFTLNPNFTIVDNKDNTAGIMTRKDGYSRNKMSTYLLPILIFDNDYPIQSSTGTLTIRVC 589

Query: 584 DCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRR-RKKEPLIFDE 642
            CD  G  Q+C AEA +L AGLSTGAL+AIL CVL LL+L++L   ++R RKKEPLI  +
Sbjct: 590 ACDNQGNMQSCTAEALILSAGLSTGALVAILLCVLILLILVVLFAALKRQRKKEPLIISK 649

Query: 643 ERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIP 702
           + D+R+NIV Y+DEGGGEEDT+AFD+  LRN     D+K RRDV PE  F  R   +++P
Sbjct: 650 D-DVRDNIVTYNDEGGGEEDTQAFDIGTLRNPEAREDSKLRRDVMPETIFQIR---RTVP 705

Query: 703 --DNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYD 760
             +N+  ++FI  RLKE D DP APPYDSL TYA+EGN S+A+SLSSL+S++++ +Q+YD
Sbjct: 706 LWENIDVQDFIHRRLKENDADPSAPPYDSLATYAYEGNDSIADSLSSLESLTADCNQDYD 765

Query: 761 YLSDWGPRFKRLADMYG 777
           YLSDWGPRFK+LADMYG
Sbjct: 766 YLSDWGPRFKKLADMYG 782


>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
          Length = 794

 Score =  926 bits (2394), Expect = 0.0
 Identities = 452/742 (60%), Positives = 563/742 (75%), Gaps = 1/742 (0%)

Query: 36  PYFQSGRSRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIF 95
           P  +S   R KR WVWNQFFVLEEY+GS+P YVGKLHSD+DKG+G++KY LSG+GA ++F
Sbjct: 43  PGQRSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVF 102

Query: 96  IIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLD 155
            IDE TGDIHA + LDREE+ +YTLRAQA+D  T KP+EPESEF+IK+QDINDNEPKFLD
Sbjct: 103 TIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLD 162

Query: 156 GPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTAL 215
           GPY A VPEMSPVG  V+QV ATDADDPTYGNSARVVYSILQGQPYFS++PKTGVI+TAL
Sbjct: 163 GPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTAL 222

Query: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275
           PNMDRE K+QY ++IQAKDM GQ GGL+GTT V +TLTDVNDNPPRFP+  +   VPES 
Sbjct: 223 PNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESS 282

Query: 276 PVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKT 335
           P+ S + RI+A D D G NAE+EY IV GDG  +F I  D++TQEG+I ++K LDFE K 
Sbjct: 283 PIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKK 342

Query: 336 SYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNI 395
           +YT ++EA+N   D RF S GPF DT TVKI V DVDEPPVFS PLY MEV E T VG I
Sbjct: 343 AYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTI 402

Query: 396 IGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAM 455
           IG V A D D  +S VRY ID  +D + YF ID N G I T + LDRE+ A +N +++A 
Sbjct: 403 IGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIAS 462

Query: 456 ESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGH 515
           +  NP    +  + I +LD+N+  PE ++ YET VCENA+PGQ+IQ +SA D+D    G 
Sbjct: 463 KVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQ 522

Query: 516 QFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSST 575
           QF F L+ +A    NF+++D ++NTA I TRRNG+ R++Q +Y+LP+ I DS  P  SST
Sbjct: 523 QFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSST 582

Query: 576 NTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKK 635
           NT+TIRVC CD+DG   +CN EA  LP GLSTGALIAIL C++ LL +++L V +RR+KK
Sbjct: 583 NTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKK 642

Query: 636 EPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSR 695
           +  +   + DIR+N++ YDDEGGGEEDT+AFD+ ALRN  VI + K RRD+ P+   L R
Sbjct: 643 KDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPR 702

Query: 696 PAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNS 755
                + DN   R+FI +RL+E DVDP APPYDSL TYA+EG+GSVAESLSS+DS+++ +
Sbjct: 703 QR-PPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEA 761

Query: 756 DQNYDYLSDWGPRFKRLADMYG 777
           DQ+YDYL+DWGPRFK LADM+G
Sbjct: 762 DQDYDYLTDWGPRFKVLADMFG 783


>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
          Length = 796

 Score =  921 bits (2380), Expect = 0.0
 Identities = 459/787 (58%), Positives = 583/787 (74%), Gaps = 13/787 (1%)

Query: 5   KVEFCHFLQLIALFLCFSGMSQAELSRSRSKPYF----QSGRS-----RTKRSWVWNQFF 55
           K  +C    L+ L +     + A   R   +P F    + G+      R+KR WVWNQFF
Sbjct: 2   KENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFF 61

Query: 56  VLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQ 115
           V+EEY G DP+ VG+LHSD+D GDG+IKYILSGEGA +IF+ID+ +G+IHATK LDREE+
Sbjct: 62  VIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREER 121

Query: 116 AYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQV 175
           A YTL AQA+DR TN+P+EP SEF++K+QDINDN P+FL   Y A VPE S VGTSV+QV
Sbjct: 122 AQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQV 181

Query: 176 TATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDM 235
           TA+DADDPTYGNSA++VYSIL+GQPYFSVE +TG+I+TALPNMDREAK++Y +VIQAKDM
Sbjct: 182 TASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDM 241

Query: 236 VGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANA 295
            G  GGLSGTT VT+TLTDVNDNPP+FP+  YQ +V E+      V R+KA D DIG N 
Sbjct: 242 GGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENG 301

Query: 296 EMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSL 355
            + Y IVDGDG+  F+I+ D ETQEG+I ++K +DFE K +Y+L++EAAN   DP+F+S 
Sbjct: 302 LVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISN 361

Query: 356 GPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSI 415
           GPF DT TVKI VED DEPP+F +P Y  EV E    G ++G V A DPD++NSP+RYSI
Sbjct: 362 GPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSI 421

Query: 416 DRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDI 475
           DR+TDL+R+F I+   G I T K LDRE  A  NITV A E  N  Q  +  VAI +LD+
Sbjct: 422 DRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDV 481

Query: 476 NDNAPEFAMDYETTVCENAQ----PGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNF 531
           NDNAP+FA  YE  +CE+ Q      Q I  ISA DKD+ +NG +F FSL  +  +N NF
Sbjct: 482 NDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNF 541

Query: 532 SLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVA 591
           +++DN+DNTA +  RR GF RQ+Q +Y LPI I D G P +SSTNTLTI+VC CD +G  
Sbjct: 542 TVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGAL 601

Query: 592 QTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEERDIRENIV 651
            +CNAEAY+L AGLSTGALIAILAC++ LLV+++L VT+RR+KKEPLI  EE D+RENI+
Sbjct: 602 LSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENII 661

Query: 652 RYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIPDNVIFREFI 711
            YDDEGGGEEDTEAFD+A L+N + I     R+D+ PE Q++ RP  +  P++V   +FI
Sbjct: 662 TYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFI 721

Query: 712 WERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKR 771
             R++EAD DP APPYDS+Q Y +EG GSVA SLSSL+S +++SD +YDYL +WGPRFK+
Sbjct: 722 NTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKK 781

Query: 772 LADMYGT 778
           LAD+YG+
Sbjct: 782 LADLYGS 788


>gi|16753221 cadherin 22 precursor [Homo sapiens]
          Length = 828

 Score =  866 bits (2237), Expect = 0.0
 Identities = 423/761 (55%), Positives = 558/761 (73%), Gaps = 25/761 (3%)

Query: 41  GRSRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDEN 100
           G  R KR WVWNQFFV+EEY G++PLYVGK+HSD D+GDG+IKY +SGEGA +IF+IDE 
Sbjct: 56  GAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDEL 115

Query: 101 TGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTA 160
           TGDIHA +RLDRE++ +YTLRAQA DR TN+ +EPESEF+IK+QDIND+EP+FL GPY  
Sbjct: 116 TGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIG 175

Query: 161 GVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDR 220
            V E+SP GTSV+QV A+DADDPTYG+SAR+VYS+L G+ +F+V+PKTGVI+TA+P++DR
Sbjct: 176 SVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDR 235

Query: 221 EAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASV 280
           E++++Y +VIQA DM GQ GGLSG+T+VT+ +TDVNDNPPRFP++ YQ+++ ES P+ + 
Sbjct: 236 ESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTA 295

Query: 281 VARIKAADADIGANAEMEYKIVDGDGLG--IFKISVDKETQEGIITIQKELDFEAKTSYT 338
           V R+KA D+D+G N +M Y + D    G  +FK++ D +TQE II +QK LDFE++  +T
Sbjct: 296 VGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHT 355

Query: 339 LRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGT 398
           + +EA NK  DPRF  LG F D   V++ V DVDEPP F  P   +EV E  QVG+++G 
Sbjct: 356 VILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGV 415

Query: 399 VAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQ 458
           V A DPD++N PVRY+IDR +DL++ F+IDA++G I T K LDRET   HNITVLAME+ 
Sbjct: 416 VTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEAD 475

Query: 459 NPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFY 518
           N +Q+ R  + I ILD+NDN PE A  YE  VCE+A+PGQ+IQ IS VD+DEP  GH+FY
Sbjct: 476 NHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFY 535

Query: 519 FSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTL 578
           F L  +A +N +FSL D +DNTA++ T+  GF RQEQ V++LPI +VDSG P+LSST TL
Sbjct: 536 FRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTL 595

Query: 579 TIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPL 638
           TIR+C CD+ G  Q+CN  A+V+ A LS GALIA+L CVL L+VL+LLI+T+RR  K  L
Sbjct: 596 TIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHL 655

Query: 639 IFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTK----------------- 681
             DE+ D+R+N+++Y+DEGGGE+DTEA+DM+ALR+L    + K                 
Sbjct: 656 SSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSG 715

Query: 682 ------TRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAF 735
                  +  +  E   L +      PD  +FR+FI  ++  AD D   PPYD+ QTYAF
Sbjct: 716 GGAGSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAF 775

Query: 736 EGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMY 776
           EG  S A SLSSL S SS S+Q++ YLS WGPRF+ LA +Y
Sbjct: 776 EGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALY 816


>gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens]
          Length = 772

 Score =  776 bits (2005), Expect = 0.0
 Identities = 404/753 (53%), Positives = 530/753 (70%), Gaps = 10/753 (1%)

Query: 32  SRSKPYFQSGRS--RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGE 89
           S++K   Q  RS  R KR WVWNQFFV EE M +   ++G+L SD+D G+ S +Y L G 
Sbjct: 26  SQTKKVKQPVRSHLRVKRGWVWNQFFVPEE-MNTTSHHIGQLRSDLDNGNNSFQYKLLGA 84

Query: 90  GASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDN 149
           GA S FIIDE TGDI+A ++LDREE++ Y LRAQ +D  T + VEPESEFVIK+ DINDN
Sbjct: 85  GAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDN 144

Query: 150 EPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTG 209
           EPKFLD PY A VPEMSP GT V+QVTA+DADDP+ GN+AR++YS+LQGQPYFSVEP TG
Sbjct: 145 EPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTG 204

Query: 210 VIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQY 269
           VI+ +   MDRE +D+Y ++IQAKDM+GQ G LSGTTSV + L+DVNDN P F    Y+ 
Sbjct: 205 VIRIS-SKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRL 263

Query: 270 NVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKEL 329
            V ES P  + +  I A D DIG NAEM+Y I + D    F I  + ETQEGI+ ++K++
Sbjct: 264 TVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQ-TFDIITNHETQEGIVILKKKV 322

Query: 330 DFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEA 389
           DFE +  Y +R +  N     + +     + TT +KI VEDVDEPP+F  P Y  EV E 
Sbjct: 323 DFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEE 382

Query: 390 TQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHN 449
           T  G+ +G V+A DPD+  SP+RYSI R+    + FNI+ N G ITT+ SLDRE +A +N
Sbjct: 383 TPQGSFVGVVSATDPDNRKSPIRYSITRS----KVFNINDN-GTITTSNSLDREISAWYN 437

Query: 450 ITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKD 509
           +++ A E  N  Q+    + + +L+IND+APEF+  YET VCENA  GQVIQ ISAVD+D
Sbjct: 438 LSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRD 497

Query: 510 EPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGS 569
           E    H FYF+L+ + TNN +F++ DN+DNTA ILT R GF  QE+ V+Y+ I I D+G 
Sbjct: 498 ESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGI 557

Query: 570 PSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVT 629
           PSL+STNTLTI VCDC   G  QTC  +  VL  G  T  +IAIL C++ +   I L + 
Sbjct: 558 PSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLG 617

Query: 630 MRRRKKEPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPE 689
           +++R+K+ L  ++  D RENI +YDDEGGGEEDTEAFD+A LR+  ++R+ KTR+  + E
Sbjct: 618 LKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAE 677

Query: 690 IQFLSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLD 749
           I+ L R + +  PD+ IFR+FI E+L+EA+ DP APP+DSLQTYAFEG GS+A SLSSL+
Sbjct: 678 IRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLE 737

Query: 750 SISSNSDQNYDYLSDWGPRFKRLADMYGTGQES 782
           S  S+ D++YDYL++ GPRFKRLA M+G+  +S
Sbjct: 738 SAVSDQDESYDYLNELGPRFKRLACMFGSAVQS 770


>gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]
          Length = 781

 Score =  751 bits (1940), Expect = 0.0
 Identities = 387/742 (52%), Positives = 515/742 (69%), Gaps = 16/742 (2%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGD 103
           RT+RSWVWNQFFV+EEY G +P+ +GKLHSDVD+G+G  KY+L+GEGA ++F+IDE TG+
Sbjct: 41  RTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGN 100

Query: 104 IHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVP 163
           IH TK LDREE+A Y L AQA+DR +N+P+EP SEF+IK+QDINDN P F  GPY A VP
Sbjct: 101 IHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVP 160

Query: 164 EMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAK 223
           EMS VGTSV+QVTA DADDP+YGNSA++VY++L G P+FSV+P+TGV++TA+PNMDRE +
Sbjct: 161 EMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQ 220

Query: 224 DQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVAR 283
           +++L+VIQAKDM G  GGLSG+T+VTVTL+DVNDNPP+FP+  YQ++V E+    ++V R
Sbjct: 221 EEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGR 280

Query: 284 IKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEA 343
           ++A D D+G NA M Y I+DG+G   F IS D + ++G++T++K LDFE++ SY+ R+EA
Sbjct: 281 LRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSYSFRVEA 340

Query: 344 ANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHD 403
            N   DP +L  GPF D  +V++ V+D  EPP F+   Y + V E    G ++G ++A D
Sbjct: 341 TNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENKAPGTLVGQISAAD 400

Query: 404 PDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQV 463
            DS  SP+RYSI  ++D ER F+I    G I TA  LDRE  A HN+TVLA E  + +Q 
Sbjct: 401 LDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWHNLTVLATELDSSAQA 460

Query: 464 GRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFS--L 521
            R  VAI  LD NDNAP+ A  Y+T VC++A PGQ+IQ I A+D+DE  N     F   L
Sbjct: 461 SRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSHVSFQGPL 520

Query: 522 TTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIR 581
             DA    NF+++DN+D +AS+L           + Y +PI + D G P+LSST T+T+ 
Sbjct: 521 GPDA----NFTVQDNRDGSASLLLPSRP-APPRHAPYLVPIELWDWGQPALSSTATVTVS 575

Query: 582 VCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFD 641
           VC C  DG   +C  EA++  AGLSTGAL+AI+ CV  LL L++L V +RR+K+E L+  
Sbjct: 576 VCRCQPDGSVASCWPEAHLSAAGLSTGALLAIITCVGALLALVVLFVALRRQKQEALMVL 635

Query: 642 EERDIRENIVRYDDEGGGEEDTEAFDMAALRNLN----VIRDTKTRRDVTPEIQFLSRPA 697
           EE D+RENI+ YDDEGGGEEDTEAFD+ AL+N +           RRDV P  +   +P 
Sbjct: 636 EEEDVRENIITYDDEGGGEEDTEAFDITALQNPDGAAPPAPGPPARRDVLPRARVSRQP- 694

Query: 698 FKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSIS--SNS 755
               P      + +  RL+EAD DPG PPYDS+Q Y +EG GS   SLSSL S S    +
Sbjct: 695 --RPPGPADVAQLLALRLREADEDPGVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGA 752

Query: 756 DQNYDYLSDWGPRFKRLADMYG 777
               + L DWGP F+ LA++YG
Sbjct: 753 PGPAEPLDDWGPLFRTLAELYG 774


>gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens]
          Length = 819

 Score =  733 bits (1893), Expect = 0.0
 Identities = 387/780 (49%), Positives = 515/780 (66%), Gaps = 54/780 (6%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGD 103
           RT+RSWVWNQFFV+EEY G +P+ +GKLHSDVD+G+G  KY+L+GEGA ++F+IDE TG+
Sbjct: 41  RTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGN 100

Query: 104 IHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVP 163
           IH TK LDREE+A Y L AQA+DR +N+P+EP SEF+IK+QDINDN P F  GPY A VP
Sbjct: 101 IHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVP 160

Query: 164 EMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAK 223
           EMS VGTSV+QVTA DADDP+YGNSA++VY++L G P+FSV+P+TGV++TA+PNMDRE +
Sbjct: 161 EMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQ 220

Query: 224 DQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVAR 283
           +++L+VIQAKDM G  GGLSG+T+VTVTL+DVNDNPP+FP+  YQ++V E+    ++V R
Sbjct: 221 EEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGR 280

Query: 284 IKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEA 343
           ++A D D+G NA M Y I+DG+G   F IS D + ++G++T++K LDFE++ SY+ R+EA
Sbjct: 281 LRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSYSFRVEA 340

Query: 344 ANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHD 403
            N   DP +L  GPF D  +V++ V+D  EPP F+   Y + V E    G ++G ++A D
Sbjct: 341 TNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENKAPGTLVGQISAAD 400

Query: 404 PDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAME------- 456
            DS  SP+RYSI  ++D ER F+I    G I TA  LDRE  A HN+TVLA E       
Sbjct: 401 LDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWHNLTVLATELGWSWGP 460

Query: 457 -------------------------------SQNPSQVGRGYVAITILDINDNAPEFAMD 485
                                            + +Q  R  VAI  LD NDNAP+ A  
Sbjct: 461 ERGWVPLLVAEWSAPAAPPQRSPVGSAVGIPQDSSAQASRVQVAIQTLDENDNAPQLAEP 520

Query: 486 YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFS--LTTDATNNHNFSLKDNKDNTASI 543
           Y+T VC++A PGQ+IQ I A+D+DE  N     F   L  DA    NF+++DN+D +AS+
Sbjct: 521 YDTFVCDSAAPGQLIQVIRALDRDEVGNSSHVSFQGPLGPDA----NFTVQDNRDGSASL 576

Query: 544 LTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPA 603
           L           + Y +PI + D G P+LSST T+T+ VC C  DG   +C  EA++  A
Sbjct: 577 LLPSRP-APPRHAPYLVPIELWDWGQPALSSTATVTVSVCRCQPDGSVASCWPEAHLSAA 635

Query: 604 GLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGEEDT 663
           GLSTGAL+AI+ CV  LL L++L V +RR+K+E L+  EE D+RENI+ YDDEGGGEEDT
Sbjct: 636 GLSTGALLAIITCVGALLALVVLFVALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDT 695

Query: 664 EAFDMAALRNLN----VIRDTKTRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEAD 719
           EAFD+ AL+N +           RRDV P  +   +P     P      + +  RL+EAD
Sbjct: 696 EAFDITALQNPDGAAPPAPGPPARRDVLPRARVSRQP---RPPGPADVAQLLALRLREAD 752

Query: 720 VDPGAPPYDSLQTYAFEGNGSVAESLSSLDSIS--SNSDQNYDYLSDWGPRFKRLADMYG 777
            DPG PPYDS+Q Y +EG GS   SLSSL S S    +    + L DWGP F+ LA++YG
Sbjct: 753 EDPGVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGAPGPAEPLDDWGPLFRTLAELYG 812


>gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens]
          Length = 784

 Score =  513 bits (1321), Expect = e-145
 Identities = 308/754 (40%), Positives = 434/754 (57%), Gaps = 26/754 (3%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGD 103
           R KR W+WNQ  + EE   S P +VGK+ S V + +   KY+L GE    +F +D  TGD
Sbjct: 44  RQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNA--KYLLKGEYVGKVFRVDAETGD 101

Query: 104 IHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVP 163
           + A +RLDRE  + Y L A  +D+ T + +E  S F IK+ D+NDN P F    + A VP
Sbjct: 102 VFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVP 161

Query: 164 EMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAK 223
           E S VGTSV+ VTA DADDPT G+ A V+Y IL+G+ YF+++  +G I T   ++DRE +
Sbjct: 162 ESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAID-NSGRIITITKSLDREKQ 220

Query: 224 DQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVAR 283
            +Y +V++A+D  G  G  SGT +V VTL D+NDN P F +  Y + VPE   V + V  
Sbjct: 221 ARYEIVVEARDAQGLRGD-SGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGS 279

Query: 284 IKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEA 343
           +   D D   N   +Y I+ GD    F I  +    EGII   K LD+E    Y+  +EA
Sbjct: 280 LFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEA 339

Query: 344 ANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHD 403
            +   D R++S  P  +   V I + DVDEPP+F  P Y  ++ E  Q   +IGTV A D
Sbjct: 340 TDPTIDLRYMS-PPAGNRAQVIINITDVDEPPIFQQPFYHFQLKE-NQKKPLIGTVLAMD 397

Query: 404 PDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAME-SQNPSQ 462
           PD++   + YSI R +D  ++F +    G I   K LDRE    +N+TV A E     + 
Sbjct: 398 PDAARHSIGYSIRRTSDKGQFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTP 456

Query: 463 VGRG---YVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYF 519
            G+     V I +LD NDNAPEFA  Y+  VCENA  GQ++ +ISA+DKD      +F F
Sbjct: 457 TGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKF 516

Query: 520 SLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLT 579
            L T+    +NF+L DN DNTA+I  +   F R+   V++LP+ I D+G PS + T+TLT
Sbjct: 517 ILNTE----NNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLT 572

Query: 580 IRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLI 639
           + VC C+  G    C  E      G+S  A++AIL C+LT+ V+ LLI   RR +K+   
Sbjct: 573 VAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARA 630

Query: 640 FDEE-RDIRENIVRYDDEGGGEEDTEAFDMAALRNL--NVIRDTKTRRDVTP----EIQF 692
             +   +I E +V YD+EGGGE DT ++D++ L ++     +  +   D  P    ++Q 
Sbjct: 631 HGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQK 690

Query: 693 LSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSIS 752
             R A  +          I  +  EAD D   PPYD+L  Y +EG+ S+AESLSSL + S
Sbjct: 691 PPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDS 750

Query: 753 SNSDQNYDYLSDWGPRFKRLADMYGTG--QESLY 784
           S+SD +YD+L+DWGPRFK LA++YG+   +E LY
Sbjct: 751 SDSDVDYDFLNDWGPRFKMLAELYGSDPREELLY 784


>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
          Length = 916

 Score =  446 bits (1147), Expect = e-125
 Identities = 298/774 (38%), Positives = 427/774 (55%), Gaps = 52/774 (6%)

Query: 40  SGRSRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASS----IF 95
           +G  R KR WV     V E   G  P  + ++ SD D  D  I+Y ++G GA      +F
Sbjct: 162 NGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDN-DIPIRYSITGVGADQPPMEVF 220

Query: 96  IIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLD 155
            ID  +G ++ T+ +DREE A Y LRA A+D   NK VE   +  I + D+NDN P+F++
Sbjct: 221 SIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNK-VENPIDLYIYVIDMNDNRPEFIN 279

Query: 156 GPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSA---RVVYSILQG--QPYFSVEPKTGV 210
             Y   V E S  GT V+ VTA DADD T  N     R+V    Q   Q  F++  +TG 
Sbjct: 280 QVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGD 339

Query: 211 IKTALPNMDREAKDQYLLVIQAKDMVGQ-NGGLSGTTSVTVTLTDVNDNPPRFPRRSYQY 269
           I T    +DRE   QY +++QA DM G  N GLS T +  +T+TDVNDNPP F   ++  
Sbjct: 340 IVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAG 399

Query: 270 NVPESLPVASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQK 327
            VPE+  V +VVA +   D D     N    Y+I+ GD  G F +  D  T EG++T+ K
Sbjct: 400 EVPENR-VETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVK 458

Query: 328 ELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVS 387
            +D+E   ++ L +  +N+      + +  F  T  V I + D++E P F S    + + 
Sbjct: 459 AVDYELNRAFMLTVMVSNQAPLASGIQMS-FQSTAGVTISIMDINEAPYFPSNHKLIRLE 517

Query: 388 EATQVGNIIGTVAAHDPDS-SNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET-- 444
           E    G ++ T +A DPD      VRYS  + +D   + +I+A +G ITTA  LDRE+  
Sbjct: 518 EGVPPGTVLTTFSAVDPDRFMQQAVRYS--KLSDPASWLHINATNGQITTAAVLDRESLY 575

Query: 445 --NAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQK 502
             N ++  T LA ++  P   G G + I ++DINDNAPE  +  E  +CE  +P      
Sbjct: 576 TKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPEL-LPKEAQICE--KPNLNAIN 632

Query: 503 ISAVDKDEPSNGHQFYFSLT-TDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLP 561
           I+A D D   N   + F L    A    N+++     + A +  R       E  +Y +P
Sbjct: 633 ITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLR---ILYLEAGMYDVP 689

Query: 562 IFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLL 621
           I + DSG+P LS+T+ + ++VC CD +G   T  A   V  AGL TGA++AIL C+L LL
Sbjct: 690 IIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGA---VAAAGLGTGAIVAILICILILL 746

Query: 622 VLILLIVT-MRRRKKE----PLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNV 676
            ++LL V  M+RR+KE     L+ D E D+R+NI++YD+EGGGEED + +D++ L+    
Sbjct: 747 TMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQD-YDLSQLQQPEA 805

Query: 677 IRDTKTR---------RDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPY 727
           +    ++         R V  E Q+  RP    +P      +FI E L+ AD DP APPY
Sbjct: 806 MGHVPSKAPGVRRVDERPVGAEPQYPIRPM---VPHPGDIGDFINEGLRAADNDPTAPPY 862

Query: 728 DSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQE 781
           DSL  + +EG+GS A S+SSL+S SS+ DQ+YDYL+DWGPRFK+LADMYG G+E
Sbjct: 863 DSLLVFDYEGSGSTAGSVSSLNS-SSSGDQDYDYLNDWGPRFKKLADMYGGGEE 915


>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
          Length = 906

 Score =  439 bits (1130), Expect = e-123
 Identities = 293/771 (38%), Positives = 420/771 (54%), Gaps = 53/771 (6%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGA----SSIFIIDE 99
           R KR WV     + E   G  P  + ++ SD DK + S++Y ++G GA    + IFII+ 
Sbjct: 156 RQKRDWVIPPINLPENSRGPFPQELVRIRSDRDK-NLSLRYSVTGPGADQPPTGIFIINP 214

Query: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159
            +G +  TK LDRE+ A + LRA A+D +    VE   + VI + D+NDN P+FL   + 
Sbjct: 215 ISGQLSVTKPLDREQIARFHLRAHAVD-INGNQVENPIDIVINVIDMNDNRPEFLHQVWN 273

Query: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP------YFSVEPKTGVIKT 213
             VPE S  GT V+ VTA DADDP   N   + Y I+   P       F++  +TG I T
Sbjct: 274 GTVPEGSKPGTYVMTVTAIDADDPNALNGM-LRYRIVSQAPSTPSPNMFTINNETGDIIT 332

Query: 214 ALPNMDREAKDQYLLVIQAKDMVGQ-NGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVP 272
               +DRE   QY L+IQA DM G    GLS T +  +T+TDVNDNPP F   ++   VP
Sbjct: 333 VAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVP 392

Query: 273 ESLPVASVVARIKAADADIGANAEME--YKIVDGDGLGIFKISVDKETQEGIITIQKELD 330
           E+  V  +VA +   D D          Y+I  GD  G F I  D  + +G++T+ K +D
Sbjct: 393 ENR-VDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPID 451

Query: 331 FEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEAT 390
           FE    + L + A N+    + +   P S T TV + V DV+E P F+     +   E  
Sbjct: 452 FETNRMFVLTVAAENQVPLAKGIQHPPQS-TATVSVTVIDVNENPYFAPNPKIIRQEEGL 510

Query: 391 QVGNIIGTVAAHDPDS-SNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET----N 445
             G ++ T  A DPD      +RY+  + +D   +  ID  +G ITT   LDRE+    N
Sbjct: 511 HAGTMLTTFTAQDPDRYMQQNIRYT--KLSDPANWLKIDPVNGQITTIAVLDRESPNVKN 568

Query: 446 AIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISA 505
            I+N T LA ++  P   G G + I +LDINDNAP+  +  E   CE   P  +   I+A
Sbjct: 569 NIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQ-VLPQEAETCETPDPNSI--NITA 625

Query: 506 VDKDEPSNGHQFYFSLT-TDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFI 564
           +D D   N   F F L  +  T   N+++     + A +  +    +  E  +Y +PI I
Sbjct: 626 LDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLK---IKFLEAGIYEVPIII 682

Query: 565 VDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLI 624
            DSG+P  S+ + L ++VC CD++G    C     ++ AGL TGA+IAIL C++ LL+L+
Sbjct: 683 TDSGNPPKSNISILRVKVCQCDSNG---DCTDVDRIVGAGLGTGAIIAILLCIIILLILV 739

Query: 625 LL-IVTMRRRKKE----PLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRD 679
           L+ +V M+RR KE     L+ D E D+R+NI++YD+EGGGEED + +D++ L+  + +  
Sbjct: 740 LMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQD-YDLSQLQQPDTVEP 798

Query: 680 TKTR---------RDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSL 730
              +         R +  E Q+   P   + P      +FI E LK AD DP APPYDSL
Sbjct: 799 DAIKPVGIRRMDERPIHAEPQY---PVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSL 855

Query: 731 QTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQE 781
             + +EG+GS A SLSSL+S SS  +Q+YDYL+DWGPRFK+LADMYG G +
Sbjct: 856 LVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDD 906


>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
          Length = 882

 Score =  405 bits (1042), Expect = e-113
 Identities = 293/787 (37%), Positives = 423/787 (53%), Gaps = 65/787 (8%)

Query: 22  SGMSQAELSRSRSKPYFQSGRSRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGS 81
           SG+    L+   S P    G  R KR WV       E   G  P  + ++ S+ DK +G 
Sbjct: 133 SGIQAELLTFPNSSP----GLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDK-EGK 187

Query: 82  IKYILSGEGASS----IFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPES 137
           + Y ++G+GA +    +FII+  TG +  T+ LDRE  A YTL + A+    N  VE   
Sbjct: 188 VFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNA-VEDPM 246

Query: 138 EFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQ 197
           E +I + D NDN+P+F    +   V E +  GTSV++VTATDADD     +A + Y+IL 
Sbjct: 247 EILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILS 306

Query: 198 GQP------YFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVT 251
             P       F++   TGVI      +DRE+   Y LV+QA D+ G+  GLS T +  +T
Sbjct: 307 QDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGE--GLSTTATAVIT 364

Query: 252 LTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEME--YKIVDGDGLGI 309
           +TD NDNPP F   +Y+  VPE+     V+  +K  DAD       E  Y I++ DG G 
Sbjct: 365 VTDTNDNPPIFNPTTYKGQVPEN-EANVVITTLKVTDADAPNTPAWEAVYTILNDDG-GQ 422

Query: 310 FKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVE 369
           F ++ +    +GI+   K LDFEAK  Y L +   N    P  +SL   + T TV + V 
Sbjct: 423 FVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTN--VVPFEVSLT--TSTATVTVDVL 478

Query: 370 DVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDS-SNSPVRYSIDRNTDLERYFNID 428
           DV+E P+F  P   +EVSE   VG  I +  A +PD+     + Y I R+T    +  I+
Sbjct: 479 DVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDT--ANWLEIN 536

Query: 429 ANSGVITTAKSLDRET-----NAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFA 483
            ++G I+T   LDRE      N+ +   ++A ++ +P   G G + + + D+NDNAP   
Sbjct: 537 PDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAP--- 593

Query: 484 MDYETTV--CENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTA 541
           +    T+  CE     QVI   + +D D P N   F   LT  A+ N  ++++ N     
Sbjct: 594 IPEPRTIFFCERNPKPQVI---NIIDADLPPNTSPFTAELTHGASAN--WTIQYNDPTQE 648

Query: 542 SILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVL 601
           SI+ +       E   Y + + ++D+ +       TL + VCDC+  G A  C  +A  +
Sbjct: 649 SIILKPK--MALEVGDYKINLKLMDNQNKD--QVTTLEVSVCDCE--GAAGVCR-KAQPV 701

Query: 602 PAGLSTGALIAILACVLTLLVLILLIVTMRRRK---KEPLIFDEERDIRENIVRYDDEGG 658
            AGL   A++ IL  +L LL+LILL++   RR+   KEPL+  E+ D R+N+  YD+EGG
Sbjct: 702 EAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEPLLPPED-DTRDNVYYYDEEGG 760

Query: 659 GEEDTEAFDMAALRNLNVIRDTKTRRDVTPEI----QFLSRPAFKSIPDNVIFREFIWER 714
           GEED + FD++ L      R   TR DV P +    ++L RPA    PD +    FI E 
Sbjct: 761 GEEDQD-FDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPAN---PDEI--GNFIDEN 814

Query: 715 LKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLAD 774
           LK AD DP APPYDSL  + +EG+GS A SLSSL+S  S+ DQ+YDYL++WG RFK+LAD
Sbjct: 815 LKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLAD 874

Query: 775 MYGTGQE 781
           MYG G++
Sbjct: 875 MYGGGED 881


>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
          Length = 829

 Score =  381 bits (978), Expect = e-105
 Identities = 271/760 (35%), Positives = 390/760 (51%), Gaps = 57/760 (7%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASS----IFIIDE 99
           R KR WV     V E   G  P  + +L S+ D+ D  I Y ++G GA S    +F +++
Sbjct: 104 RHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDR-DTKIFYSITGPGADSPPEGVFAVEK 162

Query: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159
            TG +   K LDREE A Y L   A+       VE      I + D ND++PKF    + 
Sbjct: 163 ETGWLLLNKPLDREEIAKYELFGHAVSE-NGASVEDPMNISIIVTDQNDHKPKFTQDTFR 221

Query: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP------YFSVEPKTGVIKT 213
             V E    GTSV+QVTATD DD  Y  +  V YSI   +P       F++   TG I  
Sbjct: 222 GSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISV 281

Query: 214 ALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPE 273
               +DRE   +Y L IQA DM G   G + T    V + D NDN P F  + Y+ +VPE
Sbjct: 282 ISSGLDREKVPEYTLTIQATDMDGD--GSTTTAVAVVEILDANDNAPMFDPQKYEAHVPE 339

Query: 274 SLPVASVVARIKAADADIGANAEME--YKIVDGDGLGIFKISVDKETQEGIITIQKELDF 331
           +  V   V R+   D D   +      Y I+ GD    F I+   E+ +GI+T +K LDF
Sbjct: 340 NA-VGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDF 398

Query: 332 EAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQ 391
           EAK  +TL +E  N+   P  L L   + T T+ + VEDV+E PVF  P   +EV E   
Sbjct: 399 EAKNQHTLYVEVTNEA--PFVLKLP--TSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIP 454

Query: 392 VGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET-----NA 446
            G  +    A DPD  N  + Y I R  D   +  +D +SG +T   +LDRE      N 
Sbjct: 455 TGEPVCVYTAEDPDKENQKISYRILR--DPAGWLAMDPDSGQVTAVGTLDREDEQFVRNN 512

Query: 447 IHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAV 506
           I+ + VLAM++ +P   G G + +T++D+ND+ P      + T+C  +   QV+   +  
Sbjct: 513 IYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGP-VPEPRQITICNQSPVRQVL---NIT 568

Query: 507 DKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVD 566
           DKD   +   F   LT D+  +  ++ + N++    +L+ +   +   Q  Y + + + D
Sbjct: 569 DKDLSPHTSPFQAQLTDDS--DIYWTAEVNEEGDTVVLSLKKFLK---QDTYDVHLSLSD 623

Query: 567 SGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILL 626
            G+          IR   CD  G  +TC       P     G ++ +L  VL LL L+L+
Sbjct: 624 HGNKE----QLTVIRATVCDCHGHVETC-------PGPWKGGFILPVLGAVLALLFLLLV 672

Query: 627 IVTMRRRK---KEPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAAL-RNLNVIRDTKT 682
           ++ + R+K   KEPL+  E+ D R+N+  Y +EGGGEED + +D+  L R L    +   
Sbjct: 673 LLLLVRKKRKIKEPLLLPED-DTRDNVFYYGEEGGGEEDQD-YDITQLHRGLEARPEVVL 730

Query: 683 RRDVTPEIQFLSRPAFKSIPDNVI-FREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSV 741
           R DV P I  +  P ++  P N      FI E LK A+ DP APPYD+L  + +EG+GS 
Sbjct: 731 RNDVAPTI--IPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDTLLVFDYEGSGSD 788

Query: 742 AESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQE 781
           A SLSSL S +S+ DQ+YDYL++WG RFK+LADMYG G++
Sbjct: 789 AASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGED 828


>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
          Length = 814

 Score =  372 bits (955), Expect = e-103
 Identities = 256/755 (33%), Positives = 384/755 (50%), Gaps = 34/755 (4%)

Query: 43  SRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASS----IFIID 98
           SR +R+WV     V E +    P  + ++ SD  +  GS+ Y + G G       +F ID
Sbjct: 41  SRVRRAWVIPPISVSENHKRL-PYPLVQIKSDKQQL-GSVIYSIQGPGVDEEPRGVFSID 98

Query: 99  ENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPY 158
           + TG +     LDRE+   + LRA ALD L    +E  ++  I + D NDN P FL   +
Sbjct: 99  KFTGKVFLNAMLDREKTDRFRLRAFALD-LGGSTLEDPTDLEIVVVDQNDNRPAFLQEAF 157

Query: 159 TAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP-YFSVEPKTGVIKTALPN 217
           T  V E +  GT V +  ATDADDP   N+A     + QG P  FS++  TG I+T    
Sbjct: 158 TGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVG 217

Query: 218 MDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPV 277
           +DRE    Y L +Q  DM G   GL+ T S  +TL D+NDN P F R  +     E++  
Sbjct: 218 LDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVSG 275

Query: 278 ASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKT 335
             V  R++  D D+    N    + I++GD  G F I  D +T EG+++I K LD+E+  
Sbjct: 276 VDV-GRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCE 334

Query: 336 SYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNI 395
            Y L++   N +A  +  +L        V++ V+D +EPPVF        ++E    G +
Sbjct: 335 HYELKVSVQN-EAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTL 393

Query: 396 IGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAI----HNIT 451
           + T +A DPD+     R S  ++ D E +  +DA +G I T   L   +  +    +   
Sbjct: 394 VATFSARDPDTEQLQ-RLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAI 452

Query: 452 VLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEP 511
           VLA +  +  +   G ++I IL++ND+AP  A     ++C     G  +  + A D+D P
Sbjct: 453 VLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLL-LGATDEDLP 511

Query: 512 SNGHQFYFSLTTDATN-NHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSP 570
            +G  F+F L+        N+SL     + A +  R     +  + ++ L + + DSG P
Sbjct: 512 PHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRH----QVPEGLHRLSLLLRDSGQP 567

Query: 571 SLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTM 630
                  L + VC C  DGV     A       GLS GAL+ +LA  L LLVL+LL+   
Sbjct: 568 PQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALR 627

Query: 631 RRRKKEP----LIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIR----DTKT 682
            R  K+     L+   + D+R+N++ YD++GGGEED +A+D++ LR+   +         
Sbjct: 628 ARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPL 687

Query: 683 RRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVA 742
           RRD  P+ +   +P        +   +FI + L+ AD DP  PPYD+   Y +EG+GSVA
Sbjct: 688 RRDA-PQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVA 746

Query: 743 ESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYG 777
            +LSS+ S   + DQ+YDYL DWGPRF RLADMYG
Sbjct: 747 GTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781


>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
          Length = 840

 Score =  275 bits (703), Expect = 1e-73
 Identities = 220/657 (33%), Positives = 339/657 (51%), Gaps = 52/657 (7%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99
           R+KR W      ++E  +G  P +V ++ SD  + + +I Y +SG G      ++F I++
Sbjct: 131 RSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTIFYSISGPGVDKEPFNLFYIEK 189

Query: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159
           +TGDI  T+ +DRE+   + L   A       P  P    +IKI+D NDN P F      
Sbjct: 190 DTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYP-LPLIIKIEDDNDNAPYFEHRVTI 248

Query: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP----YFSVEPKTGVIKTAL 215
             VPE    GTSV +VTATD D+P   ++ R+ Y ILQ  P    +FS+ P TGVI T  
Sbjct: 249 FTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTGVITTTT 307

Query: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275
           P +DRE  D Y L+++ +DM GQ  GL  T ++T++L D NDNPP F   SY   V E+ 
Sbjct: 308 PFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEEN- 366

Query: 276 PVASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333
            +   + R+K  D D+    +++  YKI+ G+  G F IS D  T EG++ + K L++E 
Sbjct: 367 RIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEV 426

Query: 334 KTSYTLRIEAANK-DADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQV 392
                L++   N+        S  P   TTTV + + D DE P    P+  ++  +    
Sbjct: 427 NRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPA 486

Query: 393 GNIIGTVAAHDPD-SSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET----NAI 447
           G  +    A DP+ SS   +RY   +  D + +F I+ ++G + T K LDRE+    N  
Sbjct: 487 GQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQ 544

Query: 448 HNITVLAMESQNPSQVGR---GYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKIS 504
           +NI+V+A+++     VGR   G + + + D ND+AP+  +D E T+C+N +   V++   
Sbjct: 545 YNISVVAVDA-----VGRSCTGTLVVHLDDYNDHAPQ--IDKEVTICQNNEDFAVLK--- 594

Query: 505 AVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFI 564
            VD D P NG  F F L   A+ N N   KD K  TA +  R+N     + + Y +PI I
Sbjct: 595 PVDPDGPENGPPFQFFLDNSASKNWNIEEKDGK--TAILRQRQN----LDYNYYSVPIQI 648

Query: 565 VDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLI 624
            D     L +T+ LT+RVCDC      +  +     +   +  G   AILA VL  ++L+
Sbjct: 649 KD--RHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRW-AILAMVLGSVLLL 705

Query: 625 LLI-----VTMRRRKKEPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNV 676
            ++     VT +R  K+   F E+   ++N++  + EG GEE TEA     ++  N+
Sbjct: 706 CILFTCFCVTAKRTVKK--CFPED-IAQQNLIVSNTEGPGEEVTEANIRLPMQTSNI 759


>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
           sapiens]
          Length = 894

 Score =  275 bits (703), Expect = 1e-73
 Identities = 220/657 (33%), Positives = 339/657 (51%), Gaps = 52/657 (7%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99
           R+KR W      ++E  +G  P +V ++ SD  + + +I Y +SG G      ++F I++
Sbjct: 131 RSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTIFYSISGPGVDKEPFNLFYIEK 189

Query: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159
           +TGDI  T+ +DRE+   + L   A       P  P    +IKI+D NDN P F      
Sbjct: 190 DTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYP-LPLIIKIEDDNDNAPYFEHRVTI 248

Query: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP----YFSVEPKTGVIKTAL 215
             VPE    GTSV +VTATD D+P   ++ R+ Y ILQ  P    +FS+ P TGVI T  
Sbjct: 249 FTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTGVITTTT 307

Query: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275
           P +DRE  D Y L+++ +DM GQ  GL  T ++T++L D NDNPP F   SY   V E+ 
Sbjct: 308 PFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEEN- 366

Query: 276 PVASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333
            +   + R+K  D D+    +++  YKI+ G+  G F IS D  T EG++ + K L++E 
Sbjct: 367 RIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEV 426

Query: 334 KTSYTLRIEAANK-DADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQV 392
                L++   N+        S  P   TTTV + + D DE P    P+  ++  +    
Sbjct: 427 NRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPA 486

Query: 393 GNIIGTVAAHDPD-SSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET----NAI 447
           G  +    A DP+ SS   +RY   +  D + +F I+ ++G + T K LDRE+    N  
Sbjct: 487 GQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQ 544

Query: 448 HNITVLAMESQNPSQVGR---GYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKIS 504
           +NI+V+A+++     VGR   G + + + D ND+AP+  +D E T+C+N +   V++   
Sbjct: 545 YNISVVAVDA-----VGRSCTGTLVVHLDDYNDHAPQ--IDKEVTICQNNEDFAVLK--- 594

Query: 505 AVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFI 564
            VD D P NG  F F L   A+ N N   KD K  TA +  R+N     + + Y +PI I
Sbjct: 595 PVDPDGPENGPPFQFFLDNSASKNWNIEEKDGK--TAILRQRQN----LDYNYYSVPIQI 648

Query: 565 VDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLI 624
            D     L +T+ LT+RVCDC      +  +     +   +  G   AILA VL  ++L+
Sbjct: 649 KD--RHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRW-AILAMVLGSVLLL 705

Query: 625 LLI-----VTMRRRKKEPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNV 676
            ++     VT +R  K+   F E+   ++N++  + EG GEE TEA     ++  N+
Sbjct: 706 CILFTCFCVTAKRTVKK--CFPED-IAQQNLIVSNTEGPGEEVTEANIRLPMQTSNI 759


>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
          Length = 713

 Score =  267 bits (682), Expect = 3e-71
 Identities = 202/595 (33%), Positives = 309/595 (51%), Gaps = 37/595 (6%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASS----IFIIDE 99
           R KRS V +   + E      P  VGK+  D D+ + S K+ L+G+G       IF I+E
Sbjct: 135 RQKRSIVVSPILIPENQRQPFPRDVGKV-VDSDRPERS-KFRLTGKGVDQEPKGIFRINE 192

Query: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159
           NTG +  T+ LDRE  A Y L  +  D +  K +E      + + D NDN P F +GPY 
Sbjct: 193 NTGSVSVTRTLDREVIAVYQLFVETTD-VNGKTLEGPVPLEVIVIDQNDNRPIFREGPYI 251

Query: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP------YFSVEPKTGVIKT 213
             V E SP GT+V+++TA DADDP   N A + Y+I Q  P       F ++P+ G I T
Sbjct: 252 GHVMEGSPTGTTVMRMTAFDADDPATDN-ALLRYNIRQQTPDKPSPNMFYIDPEKGDIVT 310

Query: 214 ALPN--MDREAKD--QYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQY 269
            +    +DRE  +  +Y L+I+A+DM G + GL+GT + T+ + D ND+ P+F ++ +Q 
Sbjct: 311 VVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQA 370

Query: 270 NVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKEL 329
            V E      V   ++  D          Y I++G+    F+I  + +T EG++++ K L
Sbjct: 371 TVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPL 430

Query: 330 DFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEA 389
           D+E    +TL I+  N+D     +S GP S T TV I V DV+E PVF      +   E 
Sbjct: 431 DYEISAFHTLLIKVENEDPLVPDVSYGP-SSTATVHITVLDVNEGPVFYPDPMMVTRQED 489

Query: 390 TQVGNIIGTVAAHDPDS-SNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET---- 444
             VG+++ TV A DPDS  +  +RYS+ +  D   + NI+  +G + T   LDRE+    
Sbjct: 490 LSVGSVLLTVNATDPDSLQHQTIRYSVYK--DPAGWLNINPINGTVDTTAVLDRESPFVD 547

Query: 445 NAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKIS 504
           N+++    LA++S NP   G G + IT+ D+NDNAP F       VC++A+   V+  + 
Sbjct: 548 NSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAP-FIYPTVAEVCDDAKNLSVV-ILG 605

Query: 505 AVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFI 564
           A DKD   N   F F +   A  +  + +    +  A +   +N      ++ Y LPI +
Sbjct: 606 ASDKDLHPNTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQN----LNKANYNLPIMV 661

Query: 565 VDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAI--LACV 617
            DSG P +++   L ++VC C    V   CNA A  L   L +  L+++  LAC+
Sbjct: 662 TDSGKPPMTNITDLRVQVCSCRNSKV--DCNA-AGALRFSLPSVLLLSLFSLACL 713


>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
           sapiens]
          Length = 839

 Score =  261 bits (668), Expect = 1e-69
 Identities = 200/602 (33%), Positives = 307/602 (50%), Gaps = 39/602 (6%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99
           R KR W      + E  +G  PL++ ++ SD  + + ++ Y +SG G      ++F I+ 
Sbjct: 132 RAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSISGRGVDKEPLNLFYIER 190

Query: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159
           +TG++  T+ +DREE   + L A A         +      I+++D NDN P F +  Y 
Sbjct: 191 DTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRVEDENDNHPVFTEAIYN 249

Query: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP----YFSVEPKTGVIKTAL 215
             V E S  GT+V  V ATD D+P   ++ R+ YSILQ  P     FSV P TGVI T  
Sbjct: 250 FEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPRSPGLFSVHPSTGVITTVS 308

Query: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275
             +DRE  D+Y L+++ +DM GQ  GL GT++  +T+TD NDN P F + +Y+  V E+ 
Sbjct: 309 HYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENA 368

Query: 276 PVASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333
               ++ RI   D D+   AN  + + I+ G+  G FKIS DKET EG++++ K L++E 
Sbjct: 369 FNVEIL-RIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEE 427

Query: 334 KTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVG 393
                L I   N+    R +      +   V + V D+DE P  +     + + E   VG
Sbjct: 428 NRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVG 487

Query: 394 NIIGTVAAHDPDSSN-SPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET----NAIH 448
           + I    A+DP++ N + +RY   +  D + +  ID  SG I T+K LDRE     N ++
Sbjct: 488 SKINGYKAYDPENRNGNGLRYK--KLHDPKGWITIDEISGSIITSKILDREVETPKNELY 545

Query: 449 NITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDK 508
           NITVLA++  + S  G   +A+ I D+NDN PE   +Y   +C   +P      I AVD 
Sbjct: 546 NITVLAIDKDDRSCTGT--LAVNIEDVNDNPPEILQEY-VVIC---KPKMGYTDILAVDP 599

Query: 509 DEPSNGHQFYFSL-TTDATNNHNFSLKDNKDNTASILTRRN-GFRRQEQSVYYLPIFIVD 566
           DEP +G  FYFSL  T    +  +SL    D  A +  ++N GF+      Y +PI + D
Sbjct: 600 DEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQE-----YTIPITVKD 654

Query: 567 SGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILL 626
                 ++T  L + +C+C        C A +      L   A++AIL  +  L  ++L 
Sbjct: 655 RAGQ--AATKLLRVNLCECTH---PTQCRATSRSTGVILGKWAILAILLGIALLFSVLLT 709

Query: 627 IV 628
           +V
Sbjct: 710 LV 711


>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
           sapiens]
          Length = 896

 Score =  261 bits (668), Expect = 1e-69
 Identities = 200/602 (33%), Positives = 307/602 (50%), Gaps = 39/602 (6%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99
           R KR W      + E  +G  PL++ ++ SD  + + ++ Y +SG G      ++F I+ 
Sbjct: 132 RAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSISGRGVDKEPLNLFYIER 190

Query: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159
           +TG++  T+ +DREE   + L A A         +      I+++D NDN P F +  Y 
Sbjct: 191 DTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRVEDENDNHPVFTEAIYN 249

Query: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP----YFSVEPKTGVIKTAL 215
             V E S  GT+V  V ATD D+P   ++ R+ YSILQ  P     FSV P TGVI T  
Sbjct: 250 FEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPRSPGLFSVHPSTGVITTVS 308

Query: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275
             +DRE  D+Y L+++ +DM GQ  GL GT++  +T+TD NDN P F + +Y+  V E+ 
Sbjct: 309 HYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENA 368

Query: 276 PVASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333
               ++ RI   D D+   AN  + + I+ G+  G FKIS DKET EG++++ K L++E 
Sbjct: 369 FNVEIL-RIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEE 427

Query: 334 KTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVG 393
                L I   N+    R +      +   V + V D+DE P  +     + + E   VG
Sbjct: 428 NRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVG 487

Query: 394 NIIGTVAAHDPDSSN-SPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET----NAIH 448
           + I    A+DP++ N + +RY   +  D + +  ID  SG I T+K LDRE     N ++
Sbjct: 488 SKINGYKAYDPENRNGNGLRYK--KLHDPKGWITIDEISGSIITSKILDREVETPKNELY 545

Query: 449 NITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDK 508
           NITVLA++  + S  G   +A+ I D+NDN PE   +Y   +C   +P      I AVD 
Sbjct: 546 NITVLAIDKDDRSCTGT--LAVNIEDVNDNPPEILQEY-VVIC---KPKMGYTDILAVDP 599

Query: 509 DEPSNGHQFYFSL-TTDATNNHNFSLKDNKDNTASILTRRN-GFRRQEQSVYYLPIFIVD 566
           DEP +G  FYFSL  T    +  +SL    D  A +  ++N GF+      Y +PI + D
Sbjct: 600 DEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQE-----YTIPITVKD 654

Query: 567 SGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILL 626
                 ++T  L + +C+C        C A +      L   A++AIL  +  L  ++L 
Sbjct: 655 RAGQ--AATKLLRVNLCECTH---PTQCRATSRSTGVILGKWAILAILLGIALLFSVLLT 709

Query: 627 IV 628
           +V
Sbjct: 710 LV 711


>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
           sapiens]
          Length = 847

 Score =  260 bits (665), Expect = 3e-69
 Identities = 205/636 (32%), Positives = 320/636 (50%), Gaps = 37/636 (5%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99
           R KR W      +LE  +G  PL++ ++ SD  + + +I Y + G G      ++F ++ 
Sbjct: 132 RAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQ-NYTIYYSIRGPGVDQEPRNLFYVER 190

Query: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159
           +TG+++ T+ +DRE+   + + A A       P  P    +IKI+D NDN P F +  YT
Sbjct: 191 DTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELP-LPLIIKIEDENDNYPIFTEETYT 249

Query: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP----YFSVEPKTGVIKTAL 215
             + E   VGT+V QV ATD D+P   ++ R+ YSI+   P     FS+ P TGVI T  
Sbjct: 250 FTIFENCRVGTTVGQVCATDKDEPDTMHT-RLKYSIIGQVPPSPTLFSMHPTTGVITTTS 308

Query: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275
             +DRE  D+Y L I+ +DM GQ  GL  T++  + + DVND+ P F R SY  +V E+ 
Sbjct: 309 SQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENT 368

Query: 276 PVASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333
            V   + R+   D D+   AN    Y I+ G+  G FKI  D +T EG++ + K L++E 
Sbjct: 369 -VDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEE 427

Query: 334 KTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVG 393
           K    L+I   N+    R  S      T TV + VED DE P  + P+  + + E  +VG
Sbjct: 428 KQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVG 487

Query: 394 NIIGTVAAHDPDS-SNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET----NAIH 448
                  A+DP++ S+S +RY   + TD   +  ID N+G I   +SLDRE     N I+
Sbjct: 488 TTSNGYKAYDPETRSSSGIRYK--KLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIY 545

Query: 449 NITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDK 508
           NITVLA  S    +   G + I + D+NDN+P F       +C   +P     +I AVD 
Sbjct: 546 NITVLA--SDQGGRTCTGTLGIILQDVNDNSP-FIPKKTVIIC---KPTMSSAEIVAVDP 599

Query: 509 DEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSG 568
           DEP +G  F FSL +  +           ++TA+ L+ +N         Y +PI + D  
Sbjct: 600 DEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQND---PPFGSYVVPITVRD-- 654

Query: 569 SPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTG--ALIAI-LACVLTLLVLIL 625
              +SS  +L + +CDC  +    T   +  +   G+  G  A++AI L   L   +L  
Sbjct: 655 RLGMSSVTSLDVTLCDCITENDC-THRVDPRIGGGGVQLGKWAILAILLGIALLFCILFT 713

Query: 626 LIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGEE 661
           L+       K+P +  ++   ++N++  + E  G++
Sbjct: 714 LVCGASGTSKQPKVIPDDL-AQQNLIVSNTEAPGDD 748


>gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo
           sapiens]
          Length = 901

 Score =  260 bits (665), Expect = 3e-69
 Identities = 205/636 (32%), Positives = 320/636 (50%), Gaps = 37/636 (5%)

Query: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99
           R KR W      +LE  +G  PL++ ++ SD  + + +I Y + G G      ++F ++ 
Sbjct: 132 RAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQ-NYTIYYSIRGPGVDQEPRNLFYVER 190

Query: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159
           +TG+++ T+ +DRE+   + + A A       P  P    +IKI+D NDN P F +  YT
Sbjct: 191 DTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELP-LPLIIKIEDENDNYPIFTEETYT 249

Query: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP----YFSVEPKTGVIKTAL 215
             + E   VGT+V QV ATD D+P   ++ R+ YSI+   P     FS+ P TGVI T  
Sbjct: 250 FTIFENCRVGTTVGQVCATDKDEPDTMHT-RLKYSIIGQVPPSPTLFSMHPTTGVITTTS 308

Query: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275
             +DRE  D+Y L I+ +DM GQ  GL  T++  + + DVND+ P F R SY  +V E+ 
Sbjct: 309 SQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENT 368

Query: 276 PVASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333
            V   + R+   D D+   AN    Y I+ G+  G FKI  D +T EG++ + K L++E 
Sbjct: 369 -VDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEE 427

Query: 334 KTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVG 393
           K    L+I   N+    R  S      T TV + VED DE P  + P+  + + E  +VG
Sbjct: 428 KQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVG 487

Query: 394 NIIGTVAAHDPDS-SNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET----NAIH 448
                  A+DP++ S+S +RY   + TD   +  ID N+G I   +SLDRE     N I+
Sbjct: 488 TTSNGYKAYDPETRSSSGIRYK--KLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIY 545

Query: 449 NITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDK 508
           NITVLA  S    +   G + I + D+NDN+P F       +C   +P     +I AVD 
Sbjct: 546 NITVLA--SDQGGRTCTGTLGIILQDVNDNSP-FIPKKTVIIC---KPTMSSAEIVAVDP 599

Query: 509 DEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSG 568
           DEP +G  F FSL +  +           ++TA+ L+ +N         Y +PI + D  
Sbjct: 600 DEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQND---PPFGSYVVPITVRD-- 654

Query: 569 SPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTG--ALIAI-LACVLTLLVLIL 625
              +SS  +L + +CDC  +    T   +  +   G+  G  A++AI L   L   +L  
Sbjct: 655 RLGMSSVTSLDVTLCDCITENDC-THRVDPRIGGGGVQLGKWAILAILLGIALLFCILFT 713

Query: 626 LIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGEE 661
           L+       K+P +  ++   ++N++  + E  G++
Sbjct: 714 LVCGASGTSKQPKVIPDDL-AQQNLIVSNTEAPGDD 748


>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
          Length = 4588

 Score =  245 bits (625), Expect = 1e-64
 Identities = 177/518 (34%), Positives = 268/518 (51%), Gaps = 34/518 (6%)

Query: 73   SDVD-KGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNK 131
            +D D + +  I Y L G GA   F ++ +TG++  +  LDREEQA Y L  +A D     
Sbjct: 3048 TDADIRSNAEITYTLLGSGAEK-FKLNPDTGELKTSTPLDREEQAVYHLLVRATD---GG 3103

Query: 132  PVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARV 191
                ++  V+ ++D+NDN P+F   PY   V E +  GT + +V ATDAD    G + ++
Sbjct: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADA---GLNRKI 3160

Query: 192  VYSILQGQP-YFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTV 250
            +YS++      FS+   +G+I+   P +DRE +  Y L ++A D  G    L+ T +V V
Sbjct: 3161 LYSLIDSADGQFSINELSGIIQLEKP-LDRELQAVYTLSLKAVDQ-GLPRRLTATGTVIV 3218

Query: 251  TLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIF 310
            ++ D+NDNPP F  R Y   V E + V + V ++ AA  DI ANAE+ Y I+ G+  G  
Sbjct: 3219 SVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHG-- 3276

Query: 311  KISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVED 370
            K S+D +T  G + I + LD+E+   Y L +EA +             SD  TV + V D
Sbjct: 3277 KFSIDSKT--GAVFIIENLDYESSHEYYLTVEATDGGTP-------SLSDVATVNVNVTD 3327

Query: 371  V-DEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDS-SNSPVRYS-IDRNTDLERYFNI 427
            + D  PVFS   Y   +SE   +   + TV A D D  SNS + YS ID N      F I
Sbjct: 3328 INDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSS--FTI 3385

Query: 428  DANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAM-DY 486
            D   G +   K LDRET + + +TV A ++ +P +V    V I + D+NDNAP F+  +Y
Sbjct: 3386 DPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNY 3445

Query: 487  ETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTR 546
               + EN   G  + ++   D+D   NG  F+F++ T          K  + N   +L  
Sbjct: 3446 SVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDE------KAFEVNPQGVLLT 3499

Query: 547  RNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCD 584
             +  +R+E+  Y L + + D+G P LSS   + IRV +
Sbjct: 3500 SSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIE 3537



 Score =  230 bits (586), Expect = 4e-60
 Identities = 174/531 (32%), Positives = 267/531 (50%), Gaps = 32/531 (6%)

Query: 61   MGSDPLYVGKLHSDVDKG-DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYT 119
            +GS  +++    +D+D G +G + Y +SG    S F+ID  TG +     LDRE    YT
Sbjct: 732  VGSSVIFMNS--TDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYT 789

Query: 120  LRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATD 179
            L     D    +        V+ + D NDN P+FL   Y   V E   V + ++QV ATD
Sbjct: 790  LNITVYDLGIPQKAAWRLLHVVVV-DANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATD 848

Query: 180  ADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQN 239
             D    G +  V YSI+     FS++  TGV+  A P +DRE + ++ L I+A+D   + 
Sbjct: 849  KD---LGPNGHVTYSIVTDTDTFSIDSVTGVVNIARP-LDRELQHEHSLKIEARDQAREE 904

Query: 240  GGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEY 299
              L  T  V V+L DVNDNPP F   +Y+  V E LP  +V+  ++A D D+G + ++ Y
Sbjct: 905  PQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRY 964

Query: 300  KIVD-GDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPF 358
             ++D G+G      + D +   G + I ++LDFE K  Y L + A +K    + +SL   
Sbjct: 965  SLLDHGEG------NFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKG---KPVSL--- 1012

Query: 359  SDTTTVKIIVEDVDE---PPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDS-SNSPVRYS 414
            S T  V++ V DV+E   PPVFSS +    V E   VG+++ TV+AHD D+  +  +RYS
Sbjct: 1013 SSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYS 1072

Query: 415  IDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILD 474
            I R+      F I   +GVI T+  LDRE+ + + +TV A +           + I + D
Sbjct: 1073 I-RDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVED 1131

Query: 475  INDNAPEFAMD-YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSL 533
            +NDNAP+ +   Y   + EN+     + +I A D D  SN    Y    T       FS+
Sbjct: 1132 VNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY--KITSGNPQGFFSI 1189

Query: 534  KDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCD 584
                  T  I T      R++Q  + L + + D+GSP  S+   + +++ D
Sbjct: 1190 ---HPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILD 1237



 Score =  217 bits (553), Expect = 3e-56
 Identities = 173/547 (31%), Positives = 269/547 (49%), Gaps = 53/547 (9%)

Query: 63   SDPLYVGKLHSDVDKG----------DGSIKY-ILSGEGASS----IFIIDENTGDIHAT 107
            S+P Y   +  DV  G           G++ Y ++ G    S     F+ID  +G +   
Sbjct: 2704 SEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLE 2763

Query: 108  KRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSP 167
            K LD E   +Y     A     +  +    +  I+++D NDN P F   PY A + E  P
Sbjct: 2764 KSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLP 2823

Query: 168  VGTSVVQVTATDADDPTYGNSARVVYSILQGQPY-----FSVEPKTGVIKTALPNMDREA 222
             G+ V+Q+ A+DAD  T G   +V+YS+ Q Q       F++  +TG I T L  +D E 
Sbjct: 2824 GGSRVIQIRASDADSGTNG---QVMYSLDQSQSVEVIESFAINMETGWI-TTLKELDHEK 2879

Query: 223  KDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVA 282
            +D Y + + A D  G+   LS T  V VT+TDVND+PPRF    Y+  V E  P   V+A
Sbjct: 2880 RDNYQIKVVASDH-GEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIA 2938

Query: 283  RIKAADADI-GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRI 341
             +   DAD    N ++ Y I  GD LG F  +V+    E  + ++K LD E + +Y L I
Sbjct: 2939 ILSTTDADSEEINRQVTYFITGGDPLGQF--AVETIQNEWKVYVKKPLDREKRDNYLLTI 2996

Query: 342  EAANKDADPRFLSLGPFSDTTTVKIIVEDV-DEPPVFSSPLYPMEVSEATQVGNIIGTVA 400
             A +          G FS    V++ V D  D  PV    LY   + E    G +I  ++
Sbjct: 2997 TATD----------GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQIS 3046

Query: 401  AHDPD-SSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQN 459
            A D D  SN+ + Y++   +  E+ F ++ ++G + T+  LDRE  A++++ V A  +  
Sbjct: 3047 ATDADIRSNAEITYTL-LGSGAEK-FKLNPDTGELKTSTPLDREEQAVYHLLVRA--TDG 3102

Query: 460  PSQVGRGYVAITILDINDNAPEFAMD-YETTVCENAQPGQVIQKISAVDKDEPSNGHQFY 518
              +  +  + +T+ D+NDNAPEF+ D Y  TV EN +PG ++ ++ A D D   N  +  
Sbjct: 3103 GGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLN-RKIL 3161

Query: 519  FSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSP-SLSSTNT 577
            +SL   A  +  FS+ +     + I+       R+ Q+VY L +  VD G P  L++T T
Sbjct: 3162 YSLIDSA--DGQFSINE----LSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGT 3215

Query: 578  LTIRVCD 584
            + + V D
Sbjct: 3216 VIVSVLD 3222



 Score =  194 bits (492), Expect = 3e-49
 Identities = 164/527 (31%), Positives = 256/527 (48%), Gaps = 49/527 (9%)

Query: 73   SDVDKG-DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNK 131
            +D D G +G + Y +  +  +  F ID  TG ++  + LDRE Q  ++L+ +A D+   +
Sbjct: 847  TDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREE 904

Query: 132  PVEPESEFVIKI--QDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSA 189
            P +  S  V+K+  +D+NDN P F+   Y   V E  P GT ++ +   +A DP  G S 
Sbjct: 905  P-QLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWL---EAHDPDLGQSG 960

Query: 190  RVVYSILQ-GQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSV 248
            +V YS+L  G+  F V+  +G ++  +  +D E K  Y L ++AKD  G+   LS T  V
Sbjct: 961  QVRYSLLDHGEGNFDVDKLSGAVRI-VQQLDFEKKQVYNLTVRAKDK-GKPVSLSSTCYV 1018

Query: 249  TVTLTDVNDN--PPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDG 306
             V + DVN+N  PP F     +  V E  PV S+V  + A D D   + E+ Y I DG G
Sbjct: 1019 EVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSG 1078

Query: 307  LGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKI 366
            +G+FKI      + G+I     LD E+ + Y L + A ++        + P S    + I
Sbjct: 1079 VGVFKIG----EETGVIETSDRLDRESTSHYWLTVFATDQ-------GVVPLSSFIEIYI 1127

Query: 367  IVEDV-DEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSS-NSPVRYSIDRNTDLERY 424
             VEDV D  P  S P+Y  E+ E +     +  + A DPDSS N  + Y I      + +
Sbjct: 1128 EVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNP-QGF 1186

Query: 425  FNIDANSGVITT-AKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFA 483
            F+I   +G+ITT ++ LDRE    H + V   ++ +P +     V + ILD NDN P+F 
Sbjct: 1187 FSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFL 1246

Query: 484  MD-YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHN----FSLKDNKD 538
               Y+  + E  +P          D++  +     Y  + TD     N    +S++D  +
Sbjct: 1247 QKFYKIRLPEREKP----------DRERNARREPLYHVIATDKDEGPNAEISYSIEDGNE 1296

Query: 539  NTASILTRRNGF---RRQEQSVYY--LPIFIVDSGSPSLSSTNTLTI 580
            +    +  + G    +R   +  Y  L I  VD+G P  SST  L I
Sbjct: 1297 HGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI 1343



 Score =  182 bits (463), Expect = 8e-46
 Identities = 159/540 (29%), Positives = 250/540 (46%), Gaps = 34/540 (6%)

Query: 50   VWNQFFVLEEYMGSDPLYVGKLHSDVDKGDG-SIKYILSGEGASSIFIIDENTGDIHATK 108
            V+ + F   E   S  ++   +H   +  +G  + Y ++     S F I+ NTG I+   
Sbjct: 2181 VFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIA 2240

Query: 109  RLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPV 168
             LD E    Y L  +A D LT    E   + ++   DINDN P F    Y   + E S +
Sbjct: 2241 PLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIV--DDINDNPPVFAQQSYAVTLSEASVI 2298

Query: 169  GTSVVQVTATDAD-DPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYL 227
            GTSVVQV ATD+D +P  G S ++  +  +   +F V+  TG+I + L  +D E   Q+ 
Sbjct: 2299 GTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLI-SLLRTLDYEQSRQHT 2357

Query: 228  LVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAA 287
            + ++A D  G    LS    VTV +TD+NDNPP F ++ Y+  + E  P    V  +KA 
Sbjct: 2358 IFVRAVD--GGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAY 2415

Query: 288  DADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKD 347
            DAD     +++Y I+ G+    F I    ++  GIIT+        K  Y+L +  ++  
Sbjct: 2416 DADSSDIDKLQYSILSGNDHKHFVI----DSATGIITLSNLHRHALKPFYSLNLSVSD-- 2469

Query: 348  ADPRFLSLGPFSDTTTVKIIVEDVD-EPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDS 406
                    G F  +T V + V   +   P F    Y +E++E   +  ++  V   D DS
Sbjct: 2470 --------GVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDS 2521

Query: 407  S-NSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGR 465
                 V Y I  +   +R++  +   G I T + LDRET A   I+V  M      +V  
Sbjct: 2522 GIYGHVTYHIVNDFAKDRFYINE--RGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAF 2579

Query: 466  GYVAITILDINDNAPEF-AMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTD 524
              V + + D NDNAP+F A  YE  +  +A  G  + K+ A D DE SN    Y      
Sbjct: 2580 CTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITY------ 2633

Query: 525  ATNNHNFSLKDNKD--NTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRV 582
            A    + S+K+N +    + ++T +      E   +   +  VD+GSPS  S   + +++
Sbjct: 2634 AIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKI 2693



 Score =  176 bits (447), Expect = 6e-44
 Identities = 160/526 (30%), Positives = 249/526 (47%), Gaps = 44/526 (8%)

Query: 88   GEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVI-KIQDI 146
            GE  ++   I+      H    L  EE     + A+ L +      + E E +      +
Sbjct: 650  GENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSV 709

Query: 147  NDNEPKFLDG-PYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQG--QPYFS 203
            N + P+F    P    V E  PVG+SV+ + +TD D    G + ++VY++  G     F 
Sbjct: 710  NAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDT---GFNGKLVYAVSGGNEDSCFM 766

Query: 204  VEPKTGVIKTALPNMDREAKDQYLLVIQAKDM-VGQNGGLSGTTSVTVTLTDVNDNPPRF 262
            ++ +TG++K   P +DRE  D+Y L I   D+ + Q    +    + V + D NDNPP F
Sbjct: 767  IDMETGMLKILSP-LDRETTDKYTLNITVYDLGIPQK---AAWRLLHVVVVDANDNPPEF 822

Query: 263  PRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIV-DGDGLGIFKISVDKETQEG 321
             + SY   V E   V S + +++A D D+G N  + Y IV D D       S+D  T  G
Sbjct: 823  LQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD-----TFSIDSVT--G 875

Query: 322  IITIQKELDFEAKTSYTLRIEAANK-DADPRFLSLGPFSDTTTVKIIVEDV-DEPPVFSS 379
            ++ I + LD E +  ++L+IEA ++   +P+  S      T  VK+ +EDV D PP F  
Sbjct: 876  VVNIARPLDRELQHEHSLKIEARDQAREEPQLFS------TVVVKVSLEDVNDNPPTFIP 929

Query: 380  PLYPMEVSEATQVGNIIGTVAAHDPDSSNS-PVRYS-IDRNTDLERYFNIDANSGVITTA 437
            P Y ++V E    G +I  + AHDPD   S  VRYS +D     E  F++D  SG +   
Sbjct: 930  PNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHG---EGNFDVDKLSGAVRIV 986

Query: 438  KSLDRETNAIHNITVLAMESQNP-SQVGRGYVAITILDINDN--APEFAMDYET-TVCEN 493
            + LD E   ++N+TV A +   P S     YV + ++D+N+N   P F+   E  TV E+
Sbjct: 987  QQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKED 1046

Query: 494  AQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQ 553
            A  G ++  +SA D+D   +G   Y     D +    F + +       ++   +   R+
Sbjct: 1047 APVGSLVMTVSAHDEDARRDGEIRY--SIRDGSGVGVFKIGEE----TGVIETSDRLDRE 1100

Query: 554  EQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAY 599
              S Y+L +F  D G   LSS   + I V D + D   QT     Y
Sbjct: 1101 STSHYWLTVFATDQGVVPLSSFIEIYIEVEDVN-DNAPQTSEPVYY 1145



 Score =  176 bits (445), Expect = 1e-43
 Identities = 155/519 (29%), Positives = 244/519 (47%), Gaps = 60/519 (11%)

Query: 86   LSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQD 145
            ++G    S F +D+ TG I   K LD E+++ Y L  +A D  T       ++  IK+ D
Sbjct: 1393 ITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL----TQVFIKVID 1448

Query: 146  INDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP----- 200
             ND+ P+F    Y   +PE +   T ++Q++A D D+       +++Y++   +      
Sbjct: 1449 TNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKN-----KLIYTLQSSRDPLSLK 1503

Query: 201  YFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDM---VGQNGGLSGTTSVTVTLTDVND 257
             F ++P TG + T+   +D EA  Q+ L +  +D    V +N        + V ++D ND
Sbjct: 1504 KFRLDPATGSLYTS-EKLDHEAVHQHTLTVMVRDQDVPVKRN-----FARIVVNVSDTND 1557

Query: 258  NPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKE 317
            + P F   SY+  V ES  V SVV ++ A D D G NAE+ Y I  G+    F I    +
Sbjct: 1558 HAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMI----D 1613

Query: 318  TQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDE-PPV 376
               G I   KELD   +  Y L ++A +K +        P S+ T+V+I V   D   P 
Sbjct: 1614 PVLGSIKTAKELDRSNQAEYDLMVKATDKGSP-------PMSEITSVRIFVTIADNASPK 1666

Query: 377  FSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSI-DRNTDLERYFNIDANSGVIT 435
            F+S  Y +E+SE   +G+ +G V AH    S S V Y I D NT     F+I+ +SG I 
Sbjct: 1667 FTSKEYSVELSETVSIGSFVGMVTAH----SQSSVVYEIKDGNTG--DAFDINPHSGTII 1720

Query: 436  TAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAM-DYETTVCENA 494
            T K+LD ET  I+ + +        S      V + + D NDNAP F   +Y   + E+A
Sbjct: 1721 TQKALDFETLPIYTLIIQGTNMAGLST--NTTVLVHLQDENDNAPVFMQAEYTGLISESA 1778

Query: 495  QPGQVIQK-------ISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRR 547
                V+         I A D D+ SN    Y  +       H +   D+  +T +I T  
Sbjct: 1779 SINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSV---HTYFAIDS--STGAIHTVL 1833

Query: 548  NGFRRQEQSVYYLPIFIVDSGSPSLSS--TNTLTIRVCD 584
            +    +E S+++  + + D G+P L +     +T+ V D
Sbjct: 1834 S-LDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVID 1871



 Score =  148 bits (374), Expect = 2e-35
 Identities = 128/451 (28%), Positives = 206/451 (45%), Gaps = 39/451 (8%)

Query: 81   SIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFV 140
            S+ Y +        F I+ ++G I   K LD E    YTL  Q  +      +   +  +
Sbjct: 1696 SVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAG---LSTNTTVL 1752

Query: 141  IKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQ-------VTATDADDPTYGNSARVVY 193
            + +QD NDN P F+   YT  + E + + + V+        + A DAD  +   +A +VY
Sbjct: 1753 VHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS---NALLVY 1809

Query: 194  SILQGQ--PYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVT 251
             I++     YF+++  TG I T L ++D E    +   +Q  DM           +VTV 
Sbjct: 1810 HIVEPSVHTYFAIDSSTGAIHTVL-SLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVH 1868

Query: 252  LTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFK 311
            + D+ND PP F +  Y+ ++         V  + A DAD  A +++ Y I +G+ +G  K
Sbjct: 1869 VIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGN-IGE-K 1926

Query: 312  ISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDV 371
             S+D +T  G +T+Q      ++   T+R             S G F+  T+VKI V++ 
Sbjct: 1927 FSMDYKT--GALTVQNTTQLRSRYELTVRA------------SDGRFAGLTSVKINVKES 1972

Query: 372  DEPPV-FSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDAN 430
             E  + F+  +Y   V E +     +  + A   +  N P+ Y I    + +R F I   
Sbjct: 1973 KESHLKFTQDVYSAVVKENSTEAETLAVITAIG-NPINEPLFYHI---LNPDRRFKISRT 2028

Query: 431  SGVI-TTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFA-MDYET 488
            SGV+ TT    DRE     ++ V   E   PS V    V + + D NDNAP F  + Y  
Sbjct: 2029 SGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYA 2088

Query: 489  TVCENAQPGQVIQKISAVDKDEPSNGHQFYF 519
             V  + + G VI+ ++AVD+D   NG   Y+
Sbjct: 2089 VVKVDTEVGHVIRYVTAVDRDSGRNGEVHYY 2119



 Score =  144 bits (362), Expect = 4e-34
 Identities = 149/552 (26%), Positives = 241/552 (43%), Gaps = 39/552 (7%)

Query: 73   SDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKP 132
            SD+DK   SI   LSG      F+ID  TG I  +       + +Y+L     D +    
Sbjct: 2420 SDIDKLQYSI---LSGNDHKH-FVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVFRSS 2475

Query: 133  VEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVV 192
             +      + +   N + P FL   Y   + E +P+ T V++V  TD D   YG+   V 
Sbjct: 2476 TQVH----VTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGH---VT 2528

Query: 193  YSILQ--GQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTV 250
            Y I+    +  F +  +  +    L  +DRE   +   VI  + M    GG     +V V
Sbjct: 2529 YHIVNDFAKDRFYINERGQIF--TLEKLDRETPAEK--VISVRLMAKDAGGKVAFCTVNV 2584

Query: 251  TLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIF 310
             LTD NDN P+F    Y+ N+  S    + V ++ A+DAD G+NA++ Y I + D   + 
Sbjct: 2585 ILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAI-EADSESV- 2642

Query: 311  KISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVED 370
            K +++     G+IT ++ L       +T  + A +  +  +   +        VKI+  +
Sbjct: 2643 KENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVV-----LVYVKILPPE 2697

Query: 371  VDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDR----NTDLERYFN 426
            + + P FS P Y   VSE   +G  I  + A      +  V YS+ +     ++ +  F 
Sbjct: 2698 M-QLPKFSEPFYTFTVSEDVPIGTEIDLIRA----EHSGTVLYSLVKGNTPESNRDESFV 2752

Query: 427  IDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQ-VGRGYVAITILDINDNAPEF-AM 484
            ID  SG +   KSLD ET   +  ++LA  +Q+  + V    V+I + D NDN+P F + 
Sbjct: 2753 IDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESS 2812

Query: 485  DYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASIL 544
             YE  + EN   G  + +I A D D  +NG Q  +SL    +     S   N +     +
Sbjct: 2813 PYEAFIVENLPGGSRVIQIRASDADSGTNG-QVMYSLDQSQSVEVIESFAINME--TGWI 2869

Query: 545  TRRNGFRRQEQSVYYLPIFIVDSGSP-SLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPA 603
            T       +++  Y + +   D G    LSST  + + V D +      T       +  
Sbjct: 2870 TTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSE 2929

Query: 604  GLSTGALIAILA 615
                G +IAIL+
Sbjct: 2930 DDPQGGVIAILS 2941



 Score =  140 bits (354), Expect = 3e-33
 Identities = 150/525 (28%), Positives = 233/525 (44%), Gaps = 55/525 (10%)

Query: 61   MGSDPLYVGKLHSDVDKG-DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYT 119
            +GS  L V  L  D DKG +  + Y +      + F+ID   G I   K LDR  QA Y 
Sbjct: 1577 VGSVVLQVTAL--DKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYD 1634

Query: 120  LRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATD 179
            L  +A D+  + P+   +   I +   ++  PKF    Y+  + E   +G+ V  VTA  
Sbjct: 1635 LMVKATDK-GSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA-- 1691

Query: 180  ADDPTYGNSARVVYSILQGQ--PYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVG 237
                   + + VVY I  G     F + P +G I T    +D E    Y L+IQ  +M  
Sbjct: 1692 ------HSQSSVVYEIKDGNTGDAFDINPHSGTIITQ-KALDFETLPIYTLIIQGTNM-- 1742

Query: 238  QNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVAR-------IKAADAD 290
               GLS  T+V V L D NDN P F +  Y   + ES  + SVV         I+AADAD
Sbjct: 1743 --AGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADAD 1800

Query: 291  IGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADP 350
              +NA + Y IV+      F I    ++  G I     LD+E  + +   ++  +    P
Sbjct: 1801 KDSNALLVYHIVEPSVHTYFAI----DSSTGAIHTVLSLDYEETSIFHFTVQVHDM-GTP 1855

Query: 351  RFLSLGPFSDTTTVKIIVEDVDE-PPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSN- 408
            R  +   ++   TV +I  D+++ PPVF+ PLY   +   T  G  + TV A D DSS  
Sbjct: 1856 RLFA--EYAANVTVHVI--DINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF 1911

Query: 409  SPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYV 468
            S + YSI      E+ F++D  +G +T      + T  + +   L + + +    G   V
Sbjct: 1912 SQLIYSITEGNIGEK-FSMDYKTGALTV-----QNTTQLRSRYELTVRASDGRFAGLTSV 1965

Query: 469  AITILDINDNAPEFAMD-YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATN 527
             I + +  ++  +F  D Y   V EN+   + +  I+A+    P N   FY  L  D   
Sbjct: 1966 KINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAI--GNPINEPLFYHILNPD--- 2020

Query: 528  NHNFSLKDNKDNTASIL-TRRNGFRRQEQSVYYLPIFIVDSGSPS 571
               F +      T+ +L T    F R++Q  + + + + +   PS
Sbjct: 2021 -RRFKI----SRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPS 2060



 Score =  135 bits (340), Expect = 1e-31
 Identities = 105/387 (27%), Positives = 179/387 (46%), Gaps = 28/387 (7%)

Query: 137  SEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSIL 196
            +E ++ I  +N   P F    Y+A + E   V + VV V A   +        +V YSI 
Sbjct: 2166 AEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE------GLKVFYSIT 2219

Query: 197  QGQPY--FSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTD 254
             G P+  F++   TGVI    P +D EA   Y L I+A D +    G      V + + D
Sbjct: 2220 DGDPFSQFTINFNTGVINVIAP-LDFEAHPAYKLSIRATDSL---TGAHAEVFVDIIVDD 2275

Query: 255  VNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISV 314
            +NDNPP F ++SY   + E+  + + V +++A D+D   N  + Y++            V
Sbjct: 2276 INDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHV 2335

Query: 315  DKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDV-DE 373
            D  T  G+I++ + LD+E    +T+ + A +         +   S    V + V D+ D 
Sbjct: 2336 DSST--GLISLLRTLDYEQSRQHTIFVRAVDG-------GMPTLSSDVIVTVDVTDLNDN 2386

Query: 374  PPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSN-SPVRYSIDRNTDLERYFNIDANSG 432
            PP+F   +Y   +SE    G+ +  V A+D DSS+   ++YSI    D  ++F ID+ +G
Sbjct: 2387 PPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGND-HKHFVIDSATG 2445

Query: 433  VITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAM-DYETTVC 491
            +IT +          +++ +   +    S      V +T++  N ++P F   +YE  + 
Sbjct: 2446 IITLSNLHRHALKPFYSLNLSVSDGVFRSST---QVHVTVIGGNLHSPAFLQNEYEVELA 2502

Query: 492  ENAQPGQVIQKISAVDKDEPSNGHQFY 518
            ENA    ++ ++   D D    GH  Y
Sbjct: 2503 ENAPLHTLVMEVKTTDGDSGIYGHVTY 2529



 Score =  118 bits (296), Expect = 2e-26
 Identities = 116/448 (25%), Positives = 197/448 (43%), Gaps = 36/448 (8%)

Query: 141  IKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTA--TDADDPTYGNSARVVYSILQG 198
            I +++  ++  KF    Y+A V E S    ++  +TA     ++P +       Y IL  
Sbjct: 1967 INVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLF-------YHILNP 2019

Query: 199  QPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDN 258
               F +   +GV+ T     DRE ++ + +V++  +             V V + D NDN
Sbjct: 2020 DRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEE--HKPSAVAHVVVKVIVEDQNDN 2077

Query: 259  PPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKET 318
             P F    Y   V     V  V+  + A D D G N E+ Y + +      F+I      
Sbjct: 2078 APVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEH--FQIG----- 2130

Query: 319  QEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFS 378
              G I+++K+ + +      L    A    +P F      S    V I V +    PVF 
Sbjct: 2131 PLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAF------SAEVIVPITVMN-KAMPVFE 2183

Query: 379  SPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAK 438
             P Y  E++E+ QV + +  V A+ P+     V YSI  + D    F I+ N+GVI    
Sbjct: 2184 KPFYSAEIAESIQVHSPVVHVQANSPEGLK--VFYSI-TDGDPFSQFTINFNTGVINVIA 2240

Query: 439  SLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFA-MDYETTVCENAQPG 497
             LD E +  + +++ A +S   +     +V I + DINDN P FA   Y  T+ E +  G
Sbjct: 2241 PLDFEAHPAYKLSIRATDSLTGAH-AEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIG 2299

Query: 498  QVIQKISAVDKD-EPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQS 556
              + ++ A D D EP+ G    + +  + + +H+    D+     S+L   +  + ++ +
Sbjct: 2300 TSVVQVRATDSDSEPNRG--ISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHT 2357

Query: 557  VYYLPIFIVDSGSPSLSSTNTLTIRVCD 584
            ++   +  VD G P+LSS   +T+ V D
Sbjct: 2358 IF---VRAVDGGMPTLSSDVIVTVDVTD 2382



 Score =  118 bits (295), Expect = 2e-26
 Identities = 131/521 (25%), Positives = 226/521 (43%), Gaps = 41/521 (7%)

Query: 107 TKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMS 166
           T  L+RE + +YTL  +AL++ TN  VE  ++  +++ D ND  P F    Y+  +PE +
Sbjct: 105 TAILNREVKDHYTLIVKALEKNTN--VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENT 162

Query: 167 PVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTA--LPNMDREAKD 224
            + TS+ +V+ATDAD    G +    YS       F++ P +GVI     L  ++ +  +
Sbjct: 163 AIRTSIARVSATDAD---IGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYE 219

Query: 225 QYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARI 284
             +L       +  + G+S    +TV +   N+  P     +     P  L      A +
Sbjct: 220 MEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLS---PSELDRDPAYAIV 276

Query: 285 KAADADIGANAEM-EYKIVDGDGLGIFK-ISVDKETQEGIITIQKELDFEAKT-SYTLRI 341
              D D GAN ++    IV GD L  F+ +     ++E  +     +D+++    Y L +
Sbjct: 277 TVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTL 336

Query: 342 EAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPV-FSSPLYPMEVSEATQVGNIIGTVA 400
           +A +K   P+F      S    + +        PV F   +Y  E+SE       +  V 
Sbjct: 337 QAKDKGTPPQF------SSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVK 390

Query: 401 AHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNP 460
           A     + S +RY + ++T  +  F+++ N+G+I+  + + R+  A   + V   + +  
Sbjct: 391 AIP---AYSHLRY-VFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKAS 446

Query: 461 SQVGRGYVAITILDINDNAPEFAMD-YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYF 519
           ++V      + +L  N N PEF    Y+    EN   G  +  +SAVD DE  NG+  Y 
Sbjct: 447 TKV-----LVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTY- 500

Query: 520 SLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSP---SLSSTN 576
              + A  NH     D+   T ++ T  N        VY L I   D G P    +    
Sbjct: 501 ---SIANLNHVPFAIDH--FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLA 555

Query: 577 TLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACV 617
           T+T+   + D   + +  N E   +P  L  G  I  ++ +
Sbjct: 556 TITLNNLN-DNTPLFEKINCEG-TIPRDLGVGEQITTVSAI 594



 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 109/418 (26%), Positives = 178/418 (42%), Gaps = 57/418 (13%)

Query: 64  DPLYVGKLHSDVDKG---DGSIKYILSGEGASSIFIIDENTGD----IHATKRLDREEQA 116
           DP Y      D D+G   D +   I++G+       +    G     + A   +D +   
Sbjct: 270 DPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHP 329

Query: 117 Y-YTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGP-------YTAGVPEMSPV 168
           + Y L  QA D+ T     P     +K+  I+   P+F  GP       Y A + E +P 
Sbjct: 330 FGYNLTLQAKDKGT-----PPQFSSVKV--IHVTSPQFKAGPVKFEKDVYRAEISEFAPP 382

Query: 169 GTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLL 228
            T VV V A     P Y +  R V+    G+  FS+   TG+I    P + R+    + L
Sbjct: 383 NTPVVMVKAI----PAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEP-VKRQQAAHFEL 436

Query: 229 VIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAAD 288
            +   D          +T V V +   N NPP F + +Y+    E++P+ + V  + A D
Sbjct: 437 EVTTSDR-------KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVD 489

Query: 289 ADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTS-YTLRIEAANKD 347
            D G N  + Y I +   L     ++D  T  G ++  + LD+E     YTLRI A++  
Sbjct: 490 PDEGENGYVTYSIAN---LNHVPFAIDHFT--GAVSTSENLDYELMPRVYTLRIRASDWG 544

Query: 348 ADPRFLSLGPFSDTTTV--KIIVEDV-DEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDP 404
                    P+     V   I + ++ D  P+F        +     VG  I TV+A D 
Sbjct: 545 L--------PYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDA 596

Query: 405 DSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNA---IHNITVLAMESQN 459
           D     V+Y I+   +L+ +F+++ NSGV++  +SL     A    H++ + A + +N
Sbjct: 597 DELQL-VQYQIEAGNELD-FFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGEN 652



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 108/453 (23%), Positives = 193/453 (42%), Gaps = 43/453 (9%)

Query: 73  SDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDR----L 128
           +D D G    ++  S +  + +F I   +G I  T RLD  E   Y +   A DR     
Sbjct: 174 TDADIGTNG-EFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLY 232

Query: 129 TNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNS 188
            +  +   ++  + I+  N+  P       +    +  P   +   VT  D D    G+ 
Sbjct: 233 GSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDP---AYAIVTVDDCDQGANGDI 289

Query: 189 ARVVYSILQG---QPYFSVEPKTGVIK---TALPNMDREAKD-QYLLVIQAKDMVGQNGG 241
           A +  SI+ G   Q + +V    G  +    A+  +D ++    Y L +QAKD  G    
Sbjct: 290 ASL--SIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDK-GTPPQ 346

Query: 242 LSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKI 301
            S    + VT       P +F +  Y+  + E  P  + V  +KA    I A + + Y  
Sbjct: 347 FSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA----IPAYSHLRYVF 402

Query: 302 VDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDT 361
               G   F ++ +     G+I+I + +  +    + L +  +++ A  + L        
Sbjct: 403 KSTPGKAKFSLNYNT----GLISILEPVKRQQAAHFELEVTTSDRKASTKVL-------- 450

Query: 362 TTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSS-NSPVRYSIDRNTD 420
             VK++  +   PP F+   Y     E   +G  + +++A DPD   N  V YSI     
Sbjct: 451 --VKVLGAN-SNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNH 507

Query: 421 LERYFNIDANSGVITTAKSLDRETNA-IHNITVLAMESQNPSQVGRGYVA-ITILDINDN 478
           +   F ID  +G ++T+++LD E    ++ + + A +   P +     +A IT+ ++NDN
Sbjct: 508 VP--FAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDN 565

Query: 479 APEFA-MDYETTVCENAQPGQVIQKISAVDKDE 510
            P F  ++ E T+  +   G+ I  +SA+D DE
Sbjct: 566 TPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 103/450 (22%), Positives = 180/450 (40%), Gaps = 43/450 (9%)

Query: 127 RLTNKPVE-PESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTY 185
           RL   P++    E+ + +Q+ N     ++  P   GV    P      ++ + D++    
Sbjct: 26  RLEQTPLQFTHLEYNVTVQE-NSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSE---- 80

Query: 186 GNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGT 245
            N  +    IL    +  +  K G   TA+ N  RE KD Y L+++A +   +N  +   
Sbjct: 81  -NLFKAEEYILGDFCFLRIRTKGG--NTAILN--REVKDHYTLIVKALE---KNTNVEAR 132

Query: 246 TSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGD 305
           T V V + D ND  P F   SY  ++PE+  + + +AR+ A DADIG N E  Y   D  
Sbjct: 133 TKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRT 192

Query: 306 GLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVK 365
            +  F I        G+I +   LD+     Y + I AA  D   +       S    + 
Sbjct: 193 DM--FAI----HPTSGVIVLTGRLDYLETKLYEMEILAA--DRGMKLYGSSGISSMAKLT 244

Query: 366 IIVEDVDE--PPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLER 423
           + +E  +E  P + +  L P E+         I TV   D  ++      SI     L++
Sbjct: 245 VHIEQANECAPVITAVTLSPSELDR--DPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQ 302

Query: 424 YFNIDANSG----VITTAKSLDRETNAI-HNITVLAMESQNPSQVGR-GYVAITILDIND 477
           +  + +  G     +     +D +++   +N+T+ A +   P Q      + +T      
Sbjct: 303 FRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKA 362

Query: 478 NAPEFAMD-YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDN 536
              +F  D Y   + E A P   +  + A+    P+  H  Y   +T       FSL  N
Sbjct: 363 GPVKFEKDVYRAEISEFAPPNTPVVMVKAI----PAYSHLRYVFKST--PGKAKFSLNYN 416

Query: 537 KDNTASILTRRNGFRRQEQSVYYLPIFIVD 566
                 +++     +RQ+ + + L +   D
Sbjct: 417 ----TGLISILEPVKRQQAAHFELEVTTSD 442


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score =  228 bits (582), Expect = 1e-59
 Identities = 168/525 (32%), Positives = 263/525 (50%), Gaps = 27/525 (5%)

Query: 79   DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESE 138
            +G IKY +S      IF I+ +TG +   K LD E    + +   A+D          S 
Sbjct: 3121 NGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCS- 3179

Query: 139  FVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQG 198
              + + D+NDN P FL   Y   V E +P GT+V+ + ATDAD    G +A + Y++   
Sbjct: 3180 VTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADS---GTNAVIAYTVQSS 3236

Query: 199  QP-YFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVND 257
                F ++P TGVI T    +D E K  Y L ++A ++  +      T  V + L   N+
Sbjct: 3237 DSDLFVIDPNTGVITTQ-GFLDFETKQSYHLTVKAFNVPDEERCSFAT--VNIQLKGTNE 3293

Query: 258  NPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKE 317
              PRF  + Y + + E+ P  ++V  + A+D D+G + E+ Y I        F+I+  K+
Sbjct: 3294 YVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQIN--KK 3351

Query: 318  TQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSL-GPFSDTTTVKIIVEDVDEPPV 376
            T  G I +   LD E +   +L++ A N      F S+ G   D  TV + V D ++PP+
Sbjct: 3352 T--GQIYVSGILDREKEERVSLKVLAKN------FGSIRGADIDEVTVNVTVLDANDPPI 3403

Query: 377  FSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLER-YFNIDANSGVIT 435
            F+  +Y +++SE   +G  +  V+A D DS  S  R+S    +  E   F+I+  +G IT
Sbjct: 3404 FTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQIT 3463

Query: 436  TAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQ 495
                LDRET  I+N++VLA++S  PS  G   + +T+ DINDN P   +  E  V EN +
Sbjct: 3464 VTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVS-EGEVMENKR 3522

Query: 496  PGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQ 555
            PG ++  + + D D P N   F + L +       FSL     +TA +L+      R++ 
Sbjct: 3523 PGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSL-----STAGVLSTTREIDREQI 3577

Query: 556  SVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYV 600
            + +YL +   DSG P +SST T+ I V D   D  +Q+   E +V
Sbjct: 3578 ADFYLSVVTKDSGVPQMSSTGTVHITVID-QNDNPSQSRTVEIFV 3621



 Score =  225 bits (574), Expect = 1e-58
 Identities = 171/532 (32%), Positives = 257/532 (48%), Gaps = 33/532 (6%)

Query: 57   LEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQA 116
            +EE +G     +     D D+G  ++       GA   F ID  +GD+ AT+RLDRE ++
Sbjct: 1749 VEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDLIATRRLDRERRS 1808

Query: 117  YYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVT 176
             Y+L  +A D L +     +    I + D+ND+ PKF    Y+  +PE +  G+ V  + 
Sbjct: 1809 KYSLLVRADDGLQSS----DMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAIL 1864

Query: 177  ATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIK-TALPNMDREAKDQYLLVIQAKDM 235
            ATD D    G    +V    +   +F + P TGV   T L  +D E +  Y+L ++A+D 
Sbjct: 1865 ATDDDSGVNGEITYIVNEDDEDGIFF-LNPITGVFNLTRL--LDYEVQQYYILTVRAED- 1920

Query: 236  VGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANA 295
                GG   T  V   + DVNDNPP F   SY  ++ E+LPV S V      DAD G N+
Sbjct: 1921 ---GGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINS 1977

Query: 296  EMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSL 355
            ++ Y I  GD LG F  +VDK    G++ + K LD E+++ Y L ++  +    P     
Sbjct: 1978 QLTYSIASGDSLGQF--TVDK---NGVLKVLKALDRESQSFYNLVVQVHDLPQIP----A 2028

Query: 356  GPFSDTTTVKIIVEDV-DEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSS-NSPVRY 413
              F+ T  V II+ DV D PP F SP     + E T +  ++    A DPDS  NS + Y
Sbjct: 2029 SRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATDPDSGPNSYIEY 2087

Query: 414  SIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITIL 473
            ++     L   F+I    G +     LDRE  + + +TV+A +   PS      V + +L
Sbjct: 2088 TL--LNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVL 2145

Query: 474  DINDNAPEFAMD-YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFS 532
            DINDN P FA   Y+  + EN   G  I ++ A D DE +NG   Y     +   N  F 
Sbjct: 2146 DINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYG--IVNGNTNQEFR 2203

Query: 533  LKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCD 584
            +    D+    +T      R++   Y+L +   D GS   + T+T++I + D
Sbjct: 2204 I----DSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLD 2251



 Score =  223 bits (568), Expect = 5e-58
 Identities = 184/559 (32%), Positives = 280/559 (50%), Gaps = 51/559 (9%)

Query: 71   LHSDVDKG-DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALD--- 126
            L +D D G +G I YI++ +    IF ++  TG  + T+ LD E Q YY L  +A D   
Sbjct: 1864 LATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGG 1923

Query: 127  RLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYG 186
            + T   V         I D+NDN P F    Y+  + E  PVG++V+    TDADD   G
Sbjct: 1924 QFTTIRV------YFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADD---G 1974

Query: 187  NSARVVYSILQGQPY--FSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGG-LS 243
             ++++ YSI  G     F+V+ K GV+K  L  +DRE++  Y LV+Q  D+        +
Sbjct: 1975 INSQLTYSIASGDSLGQFTVD-KNGVLKV-LKALDRESQSFYNLVVQVHDLPQIPASRFT 2032

Query: 244  GTTSVTVTLTDVNDNPPRF--PRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKI 301
             T  V++ L DVNDNPP F  P+ +Y   +PE+ P+ +VV + +A D D G N+ +EY +
Sbjct: 2033 STAQVSIILLDVNDNPPTFLSPKLTY---IPENTPIDTVVFKAQATDPDSGPNSYIEYTL 2089

Query: 302  VDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDT 361
            ++  G    K S+   T +G + +  ELD E  ++YTL + A +K            S +
Sbjct: 2090 LNPLGN---KFSIG--TIDGEVRLTGELDREEVSNYTLTVVATDKGQPS-------LSSS 2137

Query: 362  TTVKIIVEDV-DEPPVFSSPLYPMEVSEATQVG-NIIGTVAAHDPDSSNSPVRYSI-DRN 418
            T V ++V D+ D  P+F+  LY +E++E T  G +II   AA   + +N  VRY I + N
Sbjct: 2138 TEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGN 2197

Query: 419  TDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDN 478
            T+ E  F ID+ +G IT AK LDRE    +++TV A +  +  +     V+I +LDIND 
Sbjct: 2198 TNQE--FRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDF 2255

Query: 479  APEFAMD-YETTVCEN--AQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKD 535
             P F +  Y   V EN    P  ++Q + A D D  SN    Y     +  N    S   
Sbjct: 2256 VPVFELSPYSVNVPENLGTLPRTILQ-VVARDDDRGSNSKLSYVLFGGNEDNAFTLSASG 2314

Query: 536  NKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCN 595
                T S+        R+ +  + L I   DSGSP+L+ T T+ + V D + +       
Sbjct: 2315 ELGVTQSL-------DRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASK 2367

Query: 596  AEAYVLPAGLSTGALIAIL 614
            A    +P    TG  + ++
Sbjct: 2368 AYFTTIPEDAPTGTDVLLV 2386



 Score =  219 bits (557), Expect = 1e-56
 Identities = 180/546 (32%), Positives = 262/546 (47%), Gaps = 47/546 (8%)

Query: 61  MGSDPLYVGKLHSDVDKG-DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYT 119
           +GS  L V    +D D+G +  I+Y L  EG    F +D  TG I   + LD E +  Y+
Sbjct: 265 VGSSVLQVAA--ADADEGTNADIRYRLQDEGTP--FQMDPETGLITVREPLDFEARRQYS 320

Query: 120 LRAQALDRLTNKPVEPESEFVIKIQDINDNEP--KFLDGPYT---AGVPEMSPVGTSVVQ 174
           L  QA+DR     +   +E +I++ D+NDN+P  KF   P T   A V E + VGT V  
Sbjct: 321 LTVQAMDRGVPS-LTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVAL 379

Query: 175 VTATDADDPTYGNSARVVYSILQG--QPYFSVE----PKTGVIKTALPNMDREAKDQYLL 228
           +T TDAD P    +  V   IL G  Q +F V+    P   +IK A   +DRE    Y L
Sbjct: 380 LTVTDADSPAANGNISV--QILGGNEQRHFEVQSSKVPNLSLIKVASA-LDRERIPSYNL 436

Query: 229 VIQAKDMVGQNGGL-----SGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVAR 283
            +   D  G   G      S   S+ + + D+ND+PP F ++ Y+ N+ E  P  S V+ 
Sbjct: 437 TVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSG 496

Query: 284 IKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKE--LDFEAKTSYTLRI 341
           I A D D G NA + Y IV G+GLG F IS       G++T      LD E  +   L I
Sbjct: 497 ISATDGDSGLNANLRYSIVSGNGLGWFHIS----EHSGLVTTGSSGGLDRELASQIVLNI 552

Query: 342 EAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPL-YPMEVSEATQVGNIIGTVA 400
            A ++   P+       S    V  +++  DE PVFS P  Y + V E    G  +  + 
Sbjct: 553 SARDQGVHPK------VSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLR 606

Query: 401 AHDPD-SSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQN 459
           A D D   N  VR+S+       R F +D  SG ++T  SLDRE  A +++ VLA +  +
Sbjct: 607 ATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGS 666

Query: 460 PSQVGRGYVAITILDINDNAPEF-AMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFY 518
           P Q     + +++LDINDN+P F  + Y   + EN   G  I  +SA D D  +NG   Y
Sbjct: 667 PPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKY 726

Query: 519 FSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTL 578
              +  A +   F +    +  + +++ R    R+E++ Y L I   D G+    +   +
Sbjct: 727 ---SISAGDRSRFQV----NAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIV 779

Query: 579 TIRVCD 584
           TI V D
Sbjct: 780 TITVLD 785



 Score =  213 bits (542), Expect = 6e-55
 Identities = 172/533 (32%), Positives = 266/533 (49%), Gaps = 51/533 (9%)

Query: 67   YVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALD 126
            +VG + +     + +I Y+++      +F I++ TG +     +DREEQ++Y L+  A  
Sbjct: 811  HVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVA-- 868

Query: 127  RLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYG 186
              +   V  ++   I ++D+NDN P FL    +  V E    G S+ Q  A D D+   G
Sbjct: 869  --SGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDE---G 923

Query: 187  NSARVVYSILQG-QPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDM-VGQNGGLSG 244
             +  V+YS+ Q  +  F++  K G I    P +D  A   Y + I A DM V Q   LS 
Sbjct: 924  VNGMVLYSLKQNPKNLFAINEKNGTISLLGP-LDVHA-GSYQIEILASDMGVPQ---LSS 978

Query: 245  TTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVD- 303
            +  +TV + DVNDN P F + SY+  + ES PV S   +++A+D D GAN E+ Y I + 
Sbjct: 979  SVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEG 1038

Query: 304  --GDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDT 361
              GD  GIF         +G + I+ ELD E +  Y L + A+++       ++ P S T
Sbjct: 1039 NTGDAFGIF--------PDGQLYIKSELDRELQDRYVLMVVASDR-------AVEPLSAT 1083

Query: 362  TTVKIIVEDV-DEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPD-SSNSPVRYSIDRNT 419
              V +I+EDV D  P+F+S  Y     E  + G+ +G V+A D D   N  VRYS +   
Sbjct: 1084 VNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEM-- 1141

Query: 420  DLERYFNIDANSGVITTAKSLDRET------NAIHNITVLAMESQNPSQV-GRGYVAITI 472
             ++  F + A SG IT     DRE+       A+ + TV+A +   P  +  +  V + +
Sbjct: 1142 -VQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYM 1200

Query: 473  LDINDNAPEFAMD-YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNF 531
             DINDNAP+F  D Y+ T+ E+A     + ++SA D DE +NG   Y  +         F
Sbjct: 1201 KDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSII--KGNEERQF 1258

Query: 532  SLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCD 584
            ++    D+T+  +T       +    Y L I  VDSG+  L+ST TL I + D
Sbjct: 1259 AI----DSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILD 1307



 Score =  194 bits (493), Expect = 3e-49
 Identities = 163/525 (31%), Positives = 257/525 (48%), Gaps = 48/525 (9%)

Query: 73   SDVDKGDGS-IKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNK 131
            +D D G  S + Y ++   +   F +D+N G +   K LDRE Q++Y L  Q  D     
Sbjct: 1969 TDADDGINSQLTYSIASGDSLGQFTVDKN-GVLKVLKALDRESQSFYNLVVQVHDL---- 2023

Query: 132  PVEPESEFVIKIQ------DINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTY 185
            P  P S F    Q      D+NDN P FL  P    +PE +P+ T V +  ATD D    
Sbjct: 2024 PQIPASRFTSTAQVSIILLDVNDNPPTFLS-PKLTYIPENTPIDTVVFKAQATDPDS--- 2079

Query: 186  GNSARVVYSILQGQPY-FSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSG 244
            G ++ + Y++L      FS+    G ++     +DRE    Y L + A D  GQ   LS 
Sbjct: 2080 GPNSYIEYTLLNPLGNKFSIGTIDGEVRLT-GELDREEVSNYTLTVVATDK-GQPS-LSS 2136

Query: 245  TTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDG 304
            +T V V + D+NDN P F +  Y+  + E+    + + ++ AAD D G N ++ Y IV+G
Sbjct: 2137 STEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNG 2196

Query: 305  DGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTV 364
            +    F+I    ++  G IT+ K LD E   +Y L ++A ++ + PR       +DT+TV
Sbjct: 2197 NTNQEFRI----DSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPR-------TDTSTV 2245

Query: 365  KIIVEDVDE-PPVFSSPLYPMEVSE--ATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDL 421
             I++ D+++  PVF    Y + V E   T    I+  VA  D   SNS + Y +    + 
Sbjct: 2246 SIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNE- 2304

Query: 422  ERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPE 481
            +  F + A SG +   +SLDRET     + + A +S +P+  G G + + + D+NDN P 
Sbjct: 2305 DNAFTLSA-SGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPT 2363

Query: 482  FAMD-YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNT 540
            FA   Y TT+ E+A  G  +  ++A D D   N      ++      N  F++     +T
Sbjct: 2364 FASKAYFTTIPEDAPTGTDVLLVNASDADASKN------AVIRIIGGNSQFTI---NPST 2414

Query: 541  ASILTRRNGFRRQEQSVYYLPIFIVDSGSPS-LSSTNTLTIRVCD 584
              I+T      R+ +  Y L +   D+GSP  LSS+ ++ + V D
Sbjct: 2415 GQIITSAL-LDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTD 2458



 Score =  190 bits (483), Expect = 4e-48
 Identities = 169/554 (30%), Positives = 264/554 (47%), Gaps = 42/554 (7%)

Query: 73   SDVDKGDGS-IKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNK 131
            +D D GD + + Y ++G      F I  NTG I   K+LD E Q+ Y L   A D+    
Sbjct: 1340 TDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQ-GRP 1398

Query: 132  PVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARV 191
            P       VI ++D NDN P F  G     + E  P+GTSV+ VTA D D    G   ++
Sbjct: 1399 PRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADING---QL 1455

Query: 192  VYSILQGQP---YFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDM-VGQNGGLSGTTS 247
             Y+I+Q  P   +F+++   G I T    +DRE  + + L ++A D  V          +
Sbjct: 1456 SYTIIQQMPRGNHFTIDEVKGTIYTN-AEIDREFANLFELTVKANDQAVPIETRRYALKN 1514

Query: 248  VTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGL 307
            VT+ +TD+NDN P F  ++     P ++ + SV+  I AAD D GAN E+EY+I++GD  
Sbjct: 1515 VTILVTDLNDNVPMFISQNALAADPSAV-IGSVLTTIMAADPDEGANGEIEYEIINGD-- 1571

Query: 308  GIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKII 367
                  VD+    G + +   L   ++  Y L + A +   + R         TT + II
Sbjct: 1572 -TDTFIVDR--YSGDLRVASAL-VPSQLIYNLIVSATDLGPERR-------KSTTELTII 1620

Query: 368  VEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSI----DRNTDLER 423
            ++ +D  PVF+ P Y   + E   +G  + ++ A  P  S +PV Y I         + R
Sbjct: 1621 LQGLD-GPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGR 1679

Query: 424  YFNIDANSGVITTAKSLDRETNA-IHNITVLAMESQNP-SQVGRGYVAITILDINDNAPE 481
             F I  ++G+I TA  LDRE  A ++ + V A+E      +  R  V IT+ DINDN P 
Sbjct: 1680 LFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPV 1739

Query: 482  FAMD-YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNT 540
            F  D  + TV EN   G  I +++A+D DE +N       +T    +  + S + + ++ 
Sbjct: 1740 FPTDMLDLTVEENIGDGSKIMQLTAMDADEGANA-----LVTYTIISGADDSFRIDPESG 1794

Query: 541  ASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYV 600
              I TRR    R+ +S Y L   +V +     SS   + I V D +      +    ++ 
Sbjct: 1795 DLIATRR--LDRERRSKYSL---LVRADDGLQSSDMRINITVSDVNDHTPKFSRPVYSFD 1849

Query: 601  LPAGLSTGALIAIL 614
            +P     G+L+A +
Sbjct: 1850 IPEDTIPGSLVAAI 1863



 Score =  187 bits (475), Expect = 3e-47
 Identities = 156/515 (30%), Positives = 243/515 (47%), Gaps = 39/515 (7%)

Query: 74   DVDKGDGS-IKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKP 132
            D D+G  S + Y+L G    + F +  + G++  T+ LDRE +  + L   A D   +  
Sbjct: 2286 DDDRGSNSKLSYVLFGGNEDNAFTLSAS-GELGVTQSLDRETKERFVLMITATDS-GSPA 2343

Query: 133  VEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVV 192
            +       + + D+NDN P F    Y   +PE +P GT V+ V A+DAD      S   V
Sbjct: 2344 LTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADA-----SKNAV 2398

Query: 193  YSILQGQPYFSVEPKTG-VIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVT 251
              I+ G   F++ P TG +I +AL  +DRE KD Y LV+   D  G    LS +TSV VT
Sbjct: 2399 IRIIGGNSQFTINPSTGQIITSAL--LDRETKDNYTLVVVCSD-AGSPEPLSSSTSVLVT 2455

Query: 252  LTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFK 311
            +TDVNDNPPRF    Y  ++P      S V  +   DADIG N+E+ Y +    G    K
Sbjct: 2456 VTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSL---SGRNSEK 2512

Query: 312  ISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKI-IVED 370
              +D     G I     L+  ++ ++++ ++              P +D+TTV +  V  
Sbjct: 2513 FHIDP--LRGAIMAAGPLNGASEVTFSVHVKDGGSF---------PKTDSTTVTVRFVNK 2561

Query: 371  VDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDAN 430
             D P V +     M   E   V +++ T+          P+ Y I  + +L   F ID  
Sbjct: 2562 ADFPKVRAKEQTFM-FPENQPVSSLVTTITGSS--LRGEPMSYYI-ASGNLGNTFQIDQL 2617

Query: 431  SGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMD-YETT 489
            +G ++ ++ LD E    + + + A +   P       + IT+LD+NDNAP F  D + + 
Sbjct: 2618 TGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISE 2677

Query: 490  VCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNG 549
            + EN  P +++  +SA+DKD   NG   Y  +  +  N  +FS+        S+      
Sbjct: 2678 ILENLSPRKILT-VSAMDKDSGPNGQLDYEIVNGNMEN--SFSINHATGEIRSV----RP 2730

Query: 550  FRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCD 584
              R++ S Y L I   D GSPS S++  + I + D
Sbjct: 2731 LDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILD 2765



 Score =  178 bits (452), Expect = 2e-44
 Identities = 150/516 (29%), Positives = 243/516 (47%), Gaps = 28/516 (5%)

Query: 74   DVDKG-DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKP 132
            D D G +G + Y +      + F I+  TG+I + + LDRE+ ++Y L  ++ D+    P
Sbjct: 2694 DKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDK--GSP 2751

Query: 133  VEPES-EFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARV 191
             +  S + +I I D NDN P+F    ++A VPE SP+G +V +VT +D D    G +A  
Sbjct: 2752 SQSTSVKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDED---IGINAIS 2807

Query: 192  VYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVT 251
             YSI+     F++ P TG I  + P ++RE  D+Y + + A D      G + +T VT+ 
Sbjct: 2808 RYSIMDASLPFTINPSTGDIVISRP-LNREDTDRYRIRVSAHD-----SGWTVSTDVTIF 2861

Query: 252  LTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFK 311
            +TD+NDN PRF R SY  + PE   + S V ++ A D D G+N ++ Y I          
Sbjct: 2862 VTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRIN 2921

Query: 312  ISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDV 371
             +  +   + I+  Q    F             + D     L     S+TT    IV+  
Sbjct: 2922 ATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSL----ISETTVTINIVDSN 2977

Query: 372  DEPPVFSSPLYPMEVSEATQVG-NIIGTVAAHDPD-SSNSPVRYSIDRNTDLERYFNIDA 429
            D  P F    Y   V++  +VG  +I   A  D D   NS V Y I  +  L + F +D 
Sbjct: 2978 DNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGK-FKLDN 3036

Query: 430  NSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDY-ET 488
            ++G I+ A SL  + N    ITV A +  NP    +  V IT+ + N + PEF+  +   
Sbjct: 3037 DTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSA 3096

Query: 489  TVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRN 548
            T+ E+   G +++ +SA D+D   NG   Y    +       F++    +++  ILT   
Sbjct: 3097 TIPESHSIGSIVRTVSARDRDAAMNGLIKY--SISSGNEEGIFAI----NSSTGILTLAK 3150

Query: 549  GFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCD 584
                +    + + I  +D G  + +   ++T+ V D
Sbjct: 3151 ALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVID 3186



 Score =  173 bits (438), Expect = 6e-43
 Identities = 138/466 (29%), Positives = 214/466 (45%), Gaps = 27/466 (5%)

Query: 73   SDVDKG-DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNK 131
            SD D G +G I Y ++       F I  + G ++    LDRE Q  Y L   A DR   +
Sbjct: 1021 SDKDSGANGEIAYTIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLMVVASDRAV-E 1078

Query: 132  PVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARV 191
            P+       + ++D+NDN P F    YT    E    G+ V +V+A D D   +G +  V
Sbjct: 1079 PLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKD---FGPNGEV 1135

Query: 192  VYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQ------YLLVIQAKDMVGQNGGLSGT 245
             YS    QP F +   +G I T     DRE+  +      +   + A D  G    L   
Sbjct: 1136 RYSFEMVQPDFELHAISGEI-TNTHQFDRESLMRRRGTAVFSFTVIATDQ-GIPQPLKDQ 1193

Query: 246  TSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGD 305
             +V V + D+NDN P+F +  YQ  + ES    + V R+ A+D D G N  + Y I+ G+
Sbjct: 1194 ATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGN 1253

Query: 306  GLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVK 365
                F I    ++  G +T+  +LD+EA  +Y+L I+A +    P        + T T+ 
Sbjct: 1254 EERQFAI----DSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIP-------LNSTCTLN 1302

Query: 366  I-IVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERY 424
            I I+++ D  P F      ++V E  ++G ++ +V A D DS ++   Y     T+    
Sbjct: 1303 IDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGT 1362

Query: 425  FNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAM 484
            F+I  N+G I  AK LD ET +++ + + A +   P +     V I + D NDN P F  
Sbjct: 1363 FSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPP 1422

Query: 485  -DYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNH 529
             D   ++ EN   G  +  ++A D D   NG   Y  +      NH
Sbjct: 1423 GDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNH 1468



 Score =  163 bits (412), Expect = 7e-40
 Identities = 138/452 (30%), Positives = 213/452 (47%), Gaps = 35/452 (7%)

Query: 62   GSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLR 121
            G+D L V    SD D    ++  I+ G   +S F I+ +TG I  +  LDRE +  YTL 
Sbjct: 2380 GTDVLLVNA--SDADASKNAVIRIIGG---NSQFTINPSTGQIITSALLDRETKDNYTLV 2434

Query: 122  AQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDAD 181
                D  + +P+   +  ++ + D+NDN P+F   PY   +P  +  G+ V  VT TDAD
Sbjct: 2435 VVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDAD 2494

Query: 182  DPTYGNSARVVYSIL-QGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNG 240
                G ++ + YS+  +    F ++P  G I  A P        +    +  KD     G
Sbjct: 2495 ---IGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGP---LNGASEVTFSVHVKD----GG 2544

Query: 241  GLSGTTSVTVTLTDVND-NPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEY 299
                T S TVT+  VN  + P+   +   +  PE+ PV+S+V  I  +         M Y
Sbjct: 2545 SFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSL---RGEPMSY 2601

Query: 300  KIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFS 359
             I  G+    F+I    +   G ++I + LDFE    Y + IEA       R     PFS
Sbjct: 2602 YIASGNLGNTFQI----DQLTGQVSISQPLDFEKIQKYVVWIEA-------RDGGFPPFS 2650

Query: 360  DTTTVKIIVEDV-DEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSS-NSPVRYSIDR 417
                + I V DV D  P+F    +  E+ E      I+ TV+A D DS  N  + Y I  
Sbjct: 2651 SYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKIL-TVSAMDKDSGPNGQLDYEI-V 2708

Query: 418  NTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDIND 477
            N ++E  F+I+  +G I + + LDRE  + + +T+ + +  +PSQ     V I ILD ND
Sbjct: 2709 NGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDEND 2768

Query: 478  NAPEFAMDYETTVCENAQPGQVIQKISAVDKD 509
            NAP F+  +   V EN+  G  + +++  D+D
Sbjct: 2769 NAPRFSQIFSAHVPENSPLGYTVTRVTTSDED 2800



 Score =  162 bits (411), Expect = 9e-40
 Identities = 149/526 (28%), Positives = 235/526 (44%), Gaps = 43/526 (8%)

Query: 73  SDVDKGDGSIKYILSGEGASSIFIIDE----NTGDIHATKRLDREEQAYYTLRAQALDRL 128
           +D    +G+I   + G      F +      N   I     LDRE    Y L     D  
Sbjct: 385 ADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNY 444

Query: 129 TNKP---VEPESE---FVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADD 182
              P   V+  S     VI + DIND+ P F    Y   + E +P G+ V  ++ATD D 
Sbjct: 445 GAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDS 504

Query: 183 PTYGNSARVVYSILQGQP--YFSVEPKTGVIKTALPN-MDREAKDQYLLVIQAKDMVGQN 239
              G +A + YSI+ G    +F +   +G++ T     +DRE   Q +L I A+D  G +
Sbjct: 505 ---GLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQ-GVH 560

Query: 240 GGLSGTTSVTVTLTDVNDNPPRFPR-RSYQYNVPESLPVASVVARIKAADADIGANAEME 298
             +S    + VTL DVND  P F +   Y  +V E+ P  + +  ++A D D+G N  + 
Sbjct: 561 PKVS-YAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVR 619

Query: 299 YKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPF 358
           + + + +     + S   +   G ++    LD E +  Y+L + A +  + P+       
Sbjct: 620 FSLQEAE---TDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQ------- 669

Query: 359 SDTTTVKIIVEDV-DEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPD-SSNSPVRYSID 416
           S    + + + D+ D  PVF    Y   + E    G+ I TV+A DPD  +N  V+YSI 
Sbjct: 670 SSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSIS 729

Query: 417 RNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDIN 476
              D  R F ++A SGVI+T  +LDRE    + + ++A +  N     +  V IT+LD  
Sbjct: 730 AG-DRSR-FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQ 787

Query: 477 DNAPEFA-MDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKD 535
           DN P F+ + Y   V EN   G  +  +SA   D  SN       L T       F++  
Sbjct: 788 DNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSN----ISYLITTGDQKGMFAI-- 841

Query: 536 NKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIR 581
             +     LT  N   R+EQS Y L + +   G+ +  +   +T++
Sbjct: 842 --NQVTGQLTTANVIDREEQSFYQLKV-VASGGTVTGDTMVNITVK 884



 Score =  158 bits (400), Expect = 2e-38
 Identities = 148/519 (28%), Positives = 228/519 (43%), Gaps = 50/519 (9%)

Query: 93  SIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPK 152
           ++F I+ +TG ++ T  +DRE      +    L      P E      + ++D+NDN P 
Sbjct: 79  ALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVR----VLVRDLNDNAPV 134

Query: 153 FLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPY------FSVEP 206
           F D        E S  G  V+  TATD+D  + G   R  Y I++G          ++ P
Sbjct: 135 FPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRS-YRIIRGNEAGRFRLDITLNP 193

Query: 207 K---TGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFP 263
                 +   +   +DRE   QY L+++ +D         G   V VT+ D+NDNPP F 
Sbjct: 194 SGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKR--RGYLQVNVTVQDINDNPPVFG 251

Query: 264 RRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGII 323
              YQ  VPE   V S V ++ AADAD G NA++ Y++ D +G       +D ET  G+I
Sbjct: 252 SSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQD-EGT---PFQMDPET--GLI 305

Query: 324 TIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYP 383
           T+++ LDFEA+  Y+L ++A ++       SL   ++     + V D D  PV     +P
Sbjct: 306 TVREPLDFEARRQYSLTVQAMDRGVP----SLTGRAEALIQLLDVNDND--PVVKFRYFP 359

Query: 384 -----MEVSEATQVGNIIGTVAAHDPDSSNSPVRYSID-RNTDLERYFNIDA----NSGV 433
                  V E  QVG ++  +   D DS  +    S+     + +R+F + +    N  +
Sbjct: 360 ATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSL 419

Query: 434 ITTAKSLDRETNAIHNITVLAMES----QNPSQVGRGYVA---ITILDINDNAPEFAMD- 485
           I  A +LDRE    +N+TV   ++       +   R  VA   I + DIND+ P F+   
Sbjct: 420 IKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQV 479

Query: 486 YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILT 545
           Y   + E A PG  +  ISA D D   N +  Y  ++ +     + S       T S   
Sbjct: 480 YRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGS--- 536

Query: 546 RRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCD 584
              G  R+  S   L I   D G     S   L + + D
Sbjct: 537 -SGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLD 574



 Score =  151 bits (381), Expect = 3e-36
 Identities = 149/555 (26%), Positives = 251/555 (45%), Gaps = 59/555 (10%)

Query: 55   FVLEEYMGSDP-LYVGK-----LHSDVDKG-DGSIKY-ILSGEGASSIFIIDENTGDIHA 106
            F+ +  + +DP   +G      + +D D+G +G I+Y I++G+  +  FI+D  +GD+  
Sbjct: 1529 FISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGD--TDTFIVDRYSGDLRV 1586

Query: 107  TKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMS 166
               L    Q  Y L   A D L  +  +  +E  I +Q ++   P F    Y   + E  
Sbjct: 1587 ASALV-PSQLIYNLIVSATD-LGPERRKSTTELTIILQGLDG--PVFTQPKYITILKEGE 1642

Query: 167  PVGTSVVQVTATDADDPTYGNSARVVYSILQGQ-------PYFSVEPKTGVIKTALPNMD 219
            P+GT+V+ + A        G+ A V Y I+  +         F++   TG+I+TA     
Sbjct: 1643 PIGTNVISIEAASPR----GSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDR 1698

Query: 220  REAKDQYLLVIQAKDMVGQNGGLSGT--TSVTVTLTDVNDNPPRFPRRSYQYNVPESLPV 277
             +    YL+ + A   + ++     T    V +TL D+NDNPP FP       V E++  
Sbjct: 1699 EQGACLYLVDVYA---IEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGD 1755

Query: 278  ASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSY 337
             S + ++ A DAD GANA + Y I+ G     F+I    + + G +   + LD E ++ Y
Sbjct: 1756 GSKIMQLTAMDADEGANALVTYTIISGAD-DSFRI----DPESGDLIATRRLDRERRSKY 1810

Query: 338  TLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDV-DEPPVFSSPLYPMEVSEATQVGNII 396
            +L + A +          G  S    + I V DV D  P FS P+Y  ++ E T  G+++
Sbjct: 1811 SLLVRADD----------GLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLV 1860

Query: 397  GTVAAHDPDSS-NSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAM 455
              + A D DS  N  + Y ++ + D +  F ++  +GV    + LD E    + +TV A 
Sbjct: 1861 AAILATDDDSGVNGEITYIVNED-DEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAE 1919

Query: 456  ESQNPSQVGRGYVAITILDINDNAPEFAMD-YETTVCENAQPGQVIQKISAVDKDEPSNG 514
            +        R Y    ILD+NDN P F+++ Y T++ EN   G  +   +  D D+  N 
Sbjct: 1920 DGGGQFTTIRVY--FNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINS 1977

Query: 515  HQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGS-PSLS 573
               Y   + D+     F++  N      +L       R+ QS Y L + + D    P+  
Sbjct: 1978 QLTYSIASGDSLG--QFTVDKN-----GVLKVLKALDRESQSFYNLVVQVHDLPQIPASR 2030

Query: 574  STNTLTIRVCDCDAD 588
             T+T  + +   D +
Sbjct: 2031 FTSTAQVSIILLDVN 2045



 Score =  142 bits (357), Expect = 2e-33
 Identities = 121/389 (31%), Positives = 190/389 (48%), Gaps = 36/389 (9%)

Query: 73   SDVDKG-DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNK 131
            +D D+G +G ++Y +     +  F ID  TG I   K LDRE+   Y L  QA DR  + 
Sbjct: 2179 ADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDR-GST 2237

Query: 132  PVEPESEFVIKIQDINDNEPKFLDGPYTAGVPE-MSPVGTSVVQVTATDADDPTYGNSAR 190
            P    S   I + DIND  P F   PY+  VPE +  +  +++QV A D D    G++++
Sbjct: 2238 PRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDR---GSNSK 2294

Query: 191  VVYSILQGQP----YFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTT 246
            + Y +  G        S   + GV ++    +DRE K++++L+I A D    +  L+GT 
Sbjct: 2295 LSYVLFGGNEDNAFTLSASGELGVTQS----LDRETKERFVLMITATD--SGSPALTGTG 2348

Query: 247  SVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDG 306
            ++ V + DVNDN P F  ++Y   +PE  P  + V  + A+DAD   NA +  +I+ G+ 
Sbjct: 2349 TINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVI--RIIGGNS 2406

Query: 307  LGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKI 366
                + +++  T  G I     LD E K +YTL +  ++        S  P S +T+V +
Sbjct: 2407 ----QFTINPST--GQIITSALLDRETKDNYTLVVVCSDAG------SPEPLSSSTSVLV 2454

Query: 367  IVEDV-DEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPD-SSNSPVRYSID-RNTDLER 423
             V DV D PP F    Y   +   T  G+ +  V   D D   NS + YS+  RN++   
Sbjct: 2455 TVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSE--- 2511

Query: 424  YFNIDANSGVITTAKSLDRETNAIHNITV 452
             F+ID   G I  A  L+  +    ++ V
Sbjct: 2512 KFHIDPLRGAIMAAGPLNGASEVTFSVHV 2540



 Score =  141 bits (356), Expect = 2e-33
 Identities = 127/463 (27%), Positives = 213/463 (46%), Gaps = 32/463 (6%)

Query: 73   SDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKP 132
            +D D G  ++         S +F+ID NTG I     LD E +  Y L  +A     N P
Sbjct: 3219 TDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAF----NVP 3274

Query: 133  VEPESEFV---IKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSA 189
             E    F    I+++  N+  P+F+   Y   + E +P GT V +V A+D D  T G   
Sbjct: 3275 DEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVH 3334

Query: 190  RVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVT 249
             +++   + +  F +  KTG I  +   +DRE +++  L + AK+     G      +V 
Sbjct: 3335 YLIFGNSR-KKGFQINKKTGQIYVS-GILDREKEERVSLKVLAKNFGSIRGADIDEVTVN 3392

Query: 250  VTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADAD-IGANAEMEYKIVDGDGLG 308
            VT+ D ND PP F    Y   + E +P+ + V  + A D+D I + +   Y I  G+  G
Sbjct: 3393 VTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENG 3451

Query: 309  IFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIV 368
             F I+     Q G IT+  ELD E    Y L + A +             + + ++ + +
Sbjct: 3452 AFSIN----PQTGQITVTAELDRETLPIYNLSVLAVDSGTPSA-------TGSASLLVTL 3500

Query: 369  EDV-DEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPD--SSNSPVRYSIDRNTDLERYF 425
            ED+ D  P+ +  +   EV E  + G ++ T+ + DPD   +  P  Y +        YF
Sbjct: 3501 EDINDNGPMLT--VSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYF 3558

Query: 426  NIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEF-AM 484
            ++ + +GV++T + +DRE  A   ++V+  +S  P     G V IT++D NDN  +   +
Sbjct: 3559 SL-STAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTV 3617

Query: 485  DYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATN 527
            +       N  PG ++  +   D D   +   F+ SLT+  T+
Sbjct: 3618 EIFVNYYGNLFPGGILGSVKPQDPDVLDS---FHCSLTSGVTS 3657



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 66/234 (28%), Positives = 95/234 (40%), Gaps = 12/234 (5%)

Query: 61   MGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTL 120
            +G+   +V    SD         Y +     +  F I+  TG I  T  LDRE    Y L
Sbjct: 3419 IGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNL 3478

Query: 121  RAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDA 180
               A+D  T       S  ++ ++DINDN P          V E    GT V+ + +TD 
Sbjct: 3479 SVLAVDSGTPSATGSAS-LLVTLEDINDNGPMLTVS--EGEVMENKRPGTLVMTLQSTDP 3535

Query: 181  DDPTYGNSARVVYSILQGQP---YFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVG 237
            D P   N     Y +L   P   YFS+    GV+ T       +  D YL V+     V 
Sbjct: 3536 DLPP--NQGPFTYYLLSTGPATSYFSLS-TAGVLSTTREIDREQIADFYLSVVTKDSGVP 3592

Query: 238  QNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADI 291
            Q   +S T +V +T+ D NDNP +        N   +L    ++  +K  D D+
Sbjct: 3593 Q---MSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDV 3643


>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
          Length = 4557

 Score =  216 bits (550), Expect = 7e-56
 Identities = 166/517 (32%), Positives = 246/517 (47%), Gaps = 28/517 (5%)

Query: 74   DVDKG-DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKP 132
            D D G +G + + +S     S F ID  TG +     +DRE    Y L     D L N  
Sbjct: 752  DADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYD-LGNPQ 810

Query: 133  VEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVV 192
                    I ++D NDN P F+   Y+  + E S +GT ++QV A D D    G++  V 
Sbjct: 811  KSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD---LGSNGEVT 867

Query: 193  YSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTL 252
            YS+L     F++   TG++  A   +DRE+K  Y L I+A+D       L    ++ V L
Sbjct: 868  YSVLTDTQQFAINSSTGIVYVA-DQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFL 926

Query: 253  TDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKI 312
             DVND  P F   SY   V E LPV +V+A ++  D D+G   ++ Y +V+ D  G F+I
Sbjct: 927  DDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEI 985

Query: 313  SVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVD 372
                +   G I + KELD+E +  Y L + A +K    R +SL   S  + V++ V DV+
Sbjct: 986  ----DKASGAIRLSKELDYEKQQFYNLTVRAKDKG---RPVSL---SSVSFVEVEVVDVN 1035

Query: 373  E---PPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSS-NSPVRYSIDRNTDLERYFNID 428
            E    P F        V E +++G  +  V A D DS  +  ++YSI   + L R F+ID
Sbjct: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGR-FSID 1094

Query: 429  ANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMD-YE 487
              SGVIT A  LDRET   + +TV A +           V I + D+NDNAP  +   Y 
Sbjct: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154

Query: 488  TTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRR 547
              V EN+     + +I A D D  SN    Y   + +  N    ++K     T  I T  
Sbjct: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIK-----TGLITTTS 1209

Query: 548  NGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCD 584
                R++Q+ ++L + + D G     ST  + ++V D
Sbjct: 1210 RKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLD 1246



 Score =  214 bits (546), Expect = 2e-55
 Identities = 175/535 (32%), Positives = 259/535 (48%), Gaps = 34/535 (6%)

Query: 56   VLEEYMGSDPLYVGKLHSDVDKG-DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREE 114
            +L E + S+ + +     D D G +G I+Y L G G S  F+ D  +G++     LDRE 
Sbjct: 3037 LLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFL-DPESGELKTLALLDRER 3095

Query: 115  QAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQ 174
               Y+L A+A D         +S   + ++D+NDN P F    Y   V E +     + +
Sbjct: 3096 IPVYSLMAKATD---GGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTR 3152

Query: 175  VTATDADDPTYGNSARVVYSILQGQP-YFSVEPKTGVIKTALPNMDREAKDQYLLVIQAK 233
            V A D   P  G + +VVYS+       FS++  +G+I    P +DRE +  Y + ++A 
Sbjct: 3153 VQAVD---PDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQP-LDREQQSSYNISVRAT 3208

Query: 234  DMV-GQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIG 292
            D   GQ+  LS  T+VT+T+ D+NDNPP F RR Y   VPE     + V  + A   DIG
Sbjct: 3209 DQSPGQS--LSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIG 3266

Query: 293  ANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRF 352
             NAE+ Y I  G+  G FKI+     + G I++ + LD+E    + L +EA  KD     
Sbjct: 3267 TNAEITYLIRSGNEQGKFKIN----PKTGGISVSEVLDYELCKRFYLVVEA--KDGGTPA 3320

Query: 353  LSLGPFSDTTTVKIIVEDV-DEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSS-NSP 410
            LS        TV I + DV D PP FS  +Y   +SE   VG+ +  + A D DS  N  
Sbjct: 3321 LSA-----VATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQ 3375

Query: 411  VRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAI 470
            + +SI  N D +  F +D   G++   K LDRE  + +++ V A++S  P+      V I
Sbjct: 3376 IHFSI-VNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNI 3434

Query: 471  TILDINDNAPEFA-MDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNH 529
             I D+NDN+P F   +Y   + EN   G  I ++   D+D   NG  F FS+ +      
Sbjct: 3435 DISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILS-GNEEE 3493

Query: 530  NFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCD 584
             F L  +      IL     F+  E   Y L +   DSG P   S   + +RV +
Sbjct: 3494 EFVLDPH-----GILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIE 3543



 Score =  191 bits (484), Expect = 3e-48
 Identities = 157/527 (29%), Positives = 249/527 (47%), Gaps = 49/527 (9%)

Query: 74   DVDKG-DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKP 132
            D D G DG I+Y +        F ID+ +G I A   LDRE    Y L   A DR    P
Sbjct: 1069 DEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGV-VP 1127

Query: 133  VEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVV 192
            +    E  I+++D+NDN P   +  Y   V E SP   SV+Q+    A+DP   ++ ++ 
Sbjct: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQI---QAEDPDSSSNEKLT 1184

Query: 193  YSILQGQP--YFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTV 250
            Y I  G P  +F++  KTG+I T    +DRE + ++ L +   D  G       T  V V
Sbjct: 1185 YRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTD--GGPSPKQSTIWVVV 1242

Query: 251  TLTDVNDNPPRFPRRSYQYNVPES--LPVASVVARIKAADADIGANAEMEYKIVDGDGLG 308
             + D NDN P+FP + YQ  +PE         + R  A D D G NAE+ Y IVDG+  G
Sbjct: 1243 QVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDG 1302

Query: 309  IFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIV 368
              K  +D +T  G+++ +K+  F A +   L I+A +          G    ++T ++ +
Sbjct: 1303 --KFFIDPKT--GMVSSRKQ--FTAGSYDILTIKAVDN---------GRPQKSSTARLHI 1347

Query: 369  EDVDEPP------VFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLE 422
            E + +PP       F  P Y   V E+ +V  I+G V+      +N+P+ + I    + +
Sbjct: 1348 EWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSV---QPANTPLWFDI-VGGNFD 1403

Query: 423  RYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEF 482
              F+ +   G I  AK LD E  +I+N++V   +  N   V    V I +LD NDN PEF
Sbjct: 1404 SAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN---VAVTQVFIKVLDNNDNGPEF 1460

Query: 483  AM-DYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSL--TTDATNNHNFSLKDNKDN 539
            +  +Y+ T+ E+  P   I +I A D+DE    H+  +++  + D+ +   F +    D 
Sbjct: 1461 SQPNYDVTISEDVLPDTEILQIEATDRDEK---HKLSYTVHSSIDSISMRKFRI----DP 1513

Query: 540  TASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCD 586
            +  +L        + Q  + L I + D   P   +   + + V D +
Sbjct: 1514 STGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDAN 1560



 Score =  188 bits (477), Expect = 2e-47
 Identities = 159/502 (31%), Positives = 241/502 (48%), Gaps = 39/502 (7%)

Query: 94   IFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKF 153
            IF+I++ TG I   KRLDRE    +  +  A   L    +    +  IK+ D+NDN+P F
Sbjct: 2755 IFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVF 2814

Query: 154  LDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSI-LQGQP-----YFSVEPK 207
                Y   + E  PVGT + QV A D D   +G + +V YS+    QP      F+++  
Sbjct: 2815 ETSSYDTIIMEGMPVGTKLTQVRAIDMD---WGANGQVTYSLHSDSQPEKVMEAFNIDSN 2871

Query: 208  TGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSY 267
            TG I T L ++D E    +   + A D+ G+   LS T  V+V +TD+NDN P F +  Y
Sbjct: 2872 TGWIST-LKDLDHETDPTFTFSVVASDL-GEAFSLSSTALVSVRVTDINDNAPVFAQEVY 2929

Query: 268  QYNVPESLPVASVVARIKAADADIG-ANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQ 326
            + NV ES P   VVA +   D D    N ++ Y I  G+  G F + + +   E  + ++
Sbjct: 2930 RGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQ--SEWKVYVK 2987

Query: 327  KELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDV-DEPPVFSSPLYPME 385
            + LD E +  Y L I A +          G F     V++ V DV D  PV     Y   
Sbjct: 2988 RPLDREEQDIYFLNITATD----------GLFVTQAMVEVSVSDVNDNSPVCDQVAYTAL 3037

Query: 386  VSEATQVGNIIGTVAAHDPD-SSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET 444
            + E      II  V+A D D  SN  +RYS+  + + E  F +D  SG + T   LDRE 
Sbjct: 3038 LPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSE--FFLDPESGELKTLALLDRER 3095

Query: 445  NAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMD-YETTVCENAQPGQVIQKI 503
              ++++  +A  +    +  +  + + + D+NDN P F+ D Y T V EN     ++ ++
Sbjct: 3096 IPVYSL--MAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRV 3153

Query: 504  SAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIF 563
             AVD D   N  +  +SL   A     FS+    D+++ I+       R++QS Y + + 
Sbjct: 3154 QAVDPDIGIN-RKVVYSLADSA--GGVFSI----DSSSGIIILEQPLDREQQSSYNISVR 3206

Query: 564  IVD-SGSPSLSSTNTLTIRVCD 584
              D S   SLSS  T+TI V D
Sbjct: 3207 ATDQSPGQSLSSLTTVTITVLD 3228



 Score =  180 bits (457), Expect = 4e-45
 Identities = 152/502 (30%), Positives = 238/502 (47%), Gaps = 47/502 (9%)

Query: 95   FIIDENTGDIHATKRLDREEQAYYTLRAQALDRL-TNKPVEPESEFVIKIQDINDNEPKF 153
            F I+ +TG ++   +LDRE +A Y+L+ +A D+  + + +       + + D+ND  P F
Sbjct: 877  FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAF 936

Query: 154  LDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQG-QPYFSVEPKTGVIK 212
            +   Y+  V E  PVGT +  +   +  DP  G   +V YS++      F ++  +G I+
Sbjct: 937  IPSSYSVKVLEDLPVGTVIAWL---ETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIR 993

Query: 213  TALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDN--PPRFPRRSYQYN 270
             +   +D E +  Y L ++AKD  G+   LS  + V V + DVN+N   P FP  +   +
Sbjct: 994  LS-KELDYEKQQFYNLTVRAKDK-GRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGS 1051

Query: 271  VPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELD 330
            V E+  + + V ++ A D D G + E++Y I DG GLG F I    + + G+IT    LD
Sbjct: 1052 VKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSI----DDESGVITAADILD 1107

Query: 331  FEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDV-DEPPVFSSPLYPMEVSEA 389
             E   SY L + A ++   P +        T  V I VEDV D  P+ S P+Y   V E 
Sbjct: 1108 RETMGSYWLTVYATDRGVVPLY-------STIEVYIEVEDVNDNAPLTSEPIYYPVVMEN 1160

Query: 390  TQVGNIIGTVAAHDPDSS-NSPVRYSIDRNTDLERYFNIDANSGVITT-AKSLDRETNAI 447
            +     +  + A DPDSS N  + Y I      + +F I+  +G+ITT ++ LDRE  A 
Sbjct: 1161 SPKDVSVIQIQAEDPDSSSNEKLTYRITSGNP-QNFFAINIKTGLITTTSRKLDREQQAE 1219

Query: 448  HNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVD 507
            H + V   +     +    +V + +LD NDN P+F             P +V Q I   +
Sbjct: 1220 HFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-------------PEKVYQ-IKLPE 1265

Query: 508  KDEPSNGHQFYFSLTTDATNNHN----FSLKDNKDNTASILTRRNGF---RRQEQSVYY- 559
            +D    G   Y +   D     N    +S+ D  D+    +  + G    R+Q  +  Y 
Sbjct: 1266 RDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYD 1325

Query: 560  -LPIFIVDSGSPSLSSTNTLTI 580
             L I  VD+G P  SST  L I
Sbjct: 1326 ILTIKAVDNGRPQKSSTARLHI 1347



 Score =  179 bits (453), Expect = 1e-44
 Identities = 132/427 (30%), Positives = 208/427 (48%), Gaps = 25/427 (5%)

Query: 89   EGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDIND 148
            + A  +F ID ++G I   + LDRE+Q+ Y +  +A D+   + +   +   I + DIND
Sbjct: 3172 DSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDIND 3231

Query: 149  NEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQG--QPYFSVEP 206
            N P F    Y   VPE +  GT V+ V AT  D    G +A + Y I  G  Q  F + P
Sbjct: 3232 NPPVFERRDYLVTVPEDTSPGTQVLAVFATSKD---IGTNAEITYLIRSGNEQGKFKINP 3288

Query: 207  KTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRS 266
            KTG I  +   +D E   ++ LV++AKD  G    LS   +V + LTDVNDNPP+F +  
Sbjct: 3289 KTGGISVS-EVLDYELCKRFYLVVEAKD--GGTPALSAVATVNINLTDVNDNPPKFSQDV 3345

Query: 267  YQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQ 326
            Y   + E   V   V  + A D D   N ++ + IV+GD    F +    +   G++ ++
Sbjct: 3346 YSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTV----DPVLGLVKVK 3401

Query: 327  KELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDV-DEPPVFSSPLYPME 385
            K+LD E  + Y+L ++A +         +   S T TV I + DV D  PVF+   Y   
Sbjct: 3402 KKLDRERVSGYSLLVQAVDS-------GIPAMSSTATVNIDISDVNDNSPVFTPANYTAV 3454

Query: 386  VSEATQVGNIIGTVAAHDPDSSNS--PVRYSIDRNTDLERYFNIDANSGVITTAKSLDRE 443
            + E   VG  I  +   D DS ++  P  +SI    + E  F +D + G++ +A      
Sbjct: 3455 IQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNE-EEEFVLDPH-GILRSAVVFQHT 3512

Query: 444  TNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAP-EFAMDYETTVCENAQPGQVIQK 502
             +  + + V A +S  P QV   Y+ + +++ + + P    ++      E+  PG VI K
Sbjct: 3513 ESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGK 3572

Query: 503  ISAVDKD 509
            I A D+D
Sbjct: 3573 IHATDQD 3579



 Score =  177 bits (449), Expect = 3e-44
 Identities = 134/438 (30%), Positives = 228/438 (52%), Gaps = 37/438 (8%)

Query: 157  PYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQG--QPYFSVEPKTGVIKTA 214
            P    V E  PVG +++++ A DAD    G + +V+++I  G     F+++ +TG +K  
Sbjct: 730  PSDVAVKEDLPVGANILKIKAYDADS---GFNGKVLFTISDGNTDSCFNIDMETGQLKVL 786

Query: 215  LPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPES 274
            +P MDRE  D YLL I   D+   N   S    +T+ + D NDN P F + SY  N+ ES
Sbjct: 787  MP-MDREHTDLYLLNITIYDL--GNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILES 843

Query: 275  LPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAK 334
              + + + +++A D D+G+N E+ Y ++        + +++  T  GI+ +  +LD E+K
Sbjct: 844  SGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQ----QFAINSST--GIVYVADQLDRESK 897

Query: 335  TSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDE-PPVFSSPLYPMEVSEATQVG 393
             +Y+L+IEA +K    + L    FS   T+K+ ++DV++  P F    Y ++V E   VG
Sbjct: 898  ANYSLKIEARDKAESGQQL----FS-VVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVG 952

Query: 394  NIIGTVAAHDPD-SSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITV 452
             +I  +  HDPD      VRYS+    D    F ID  SG I  +K LD E    +N+TV
Sbjct: 953  TVIAWLETHDPDLGLGGQVRYSL--VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTV 1010

Query: 453  LAMESQNPSQVGR-GYVAITILDINDNA-----PEFAMDYETTVCENAQPGQVIQKISAV 506
             A +   P  +    +V + ++D+N+N      P+FA+    +V EN++ G  + +++A 
Sbjct: 1011 RAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAV--VGSVKENSRIGTSVLQVTAR 1068

Query: 507  DKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVD 566
            D+D   +G +  +S+  D +    FS+    D+ + ++T  +   R+    Y+L ++  D
Sbjct: 1069 DEDSGRDG-EIQYSI-RDGSGLGRFSI----DDESGVITAADILDRETMGSYWLTVYATD 1122

Query: 567  SGSPSLSSTNTLTIRVCD 584
             G   L ST  + I V D
Sbjct: 1123 RGVVPLYSTIEVYIEVED 1140



 Score =  171 bits (433), Expect = 2e-42
 Identities = 159/508 (31%), Positives = 244/508 (48%), Gaps = 43/508 (8%)

Query: 82   IKYILSGEGASSIFIIDENTGDIHATK-RLDREEQAYYTLRAQALDRLTNKPVEPESEFV 140
            +KY +   G    F I   +G I  T    DREEQ  Y L  +A   L +  V       
Sbjct: 2015 LKYSILNPGNK--FKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVA-RVVVR 2071

Query: 141  IKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP 200
            + I+DINDN P F+  PY A V   +  GT + QVTA D D    G +  V Y +     
Sbjct: 2072 VNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDK---GPNGEVTYVLQDDYG 2128

Query: 201  YFSVEPKTG--VIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDN 258
            +F + P +G  ++K A  N D  +  +Y + I AKD     G  S +TSV + +T VN  
Sbjct: 2129 HFEINPNSGNVILKEAF-NSDL-SNIEYGVTILAKD----GGKPSLSTSVELPITIVNKA 2182

Query: 259  PPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKET 318
             P F +  Y  +V E + + + +  I A   +      + Y I+DGD    F I  D   
Sbjct: 2183 MPVFDKPFYTASVNEDIRMNTPILSINATSPE---GQGIIYIIIDGDPFKQFNIDFDT-- 2237

Query: 319  QEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDV-DEPPVF 377
              G++ +   LD+E  ++Y L I A++     R           TV ++V DV D PP+F
Sbjct: 2238 --GVLKVVSPLDYEVTSAYKLTIRASDALTGARA--------EVTVDLLVNDVNDNPPIF 2287

Query: 378  SSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSP-VRYSIDRNT-DLERYFNIDANSGVIT 435
              P Y   +SEA+ +G  +  V + D DS N+  V Y I ++T +   YF+ID++SG+I 
Sbjct: 2288 DQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLIL 2347

Query: 436  TAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEF-AMDYETTVCENA 494
            TA+ LD E      + V +++S  PS      V I I D+NDN P F  + YE+ V E A
Sbjct: 2348 TARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELA 2407

Query: 495  QPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQE 554
              G  +  + A D D  S+  +  +S+ +   N+    L D+K   + ++T  N  +++ 
Sbjct: 2408 PRGHFVTCVQASDADS-SDFDRLEYSILSG--NDRTSFLMDSK---SGVITLSNHRKQRM 2461

Query: 555  QSVYYLPIFIVDSGSPSLSSTNTLTIRV 582
            + +Y L + + D      +ST  + IRV
Sbjct: 2462 EPLYSLNVSVSDG---LFTSTAQVHIRV 2486



 Score =  159 bits (401), Expect = 1e-38
 Identities = 146/506 (28%), Positives = 233/506 (46%), Gaps = 44/506 (8%)

Query: 88   GEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDIN 147
            G    S F  ++  G I   K LD E+++ Y +  +  D  TN  V   ++  IK+ D N
Sbjct: 1399 GGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDG-TNVAV---TQVFIKVLDNN 1454

Query: 148  DNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQG--QPYFSVE 205
            DN P+F    Y   + E     T ++Q+ ATD D+      +  V+S +       F ++
Sbjct: 1455 DNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKH--KLSYTVHSSIDSISMRKFRID 1512

Query: 206  PKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRR 265
            P TGV+ TA   +D EA+D+++L I  +D   +         V V + D ND+ P F   
Sbjct: 1513 PSTGVLYTA-ERLDHEAQDKHILNIMVRDQ--EFPYRRNLARVIVNVEDANDHSPYFTNP 1569

Query: 266  SYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITI 325
             Y+ +V ES  + S V ++ A D D G NAE+ Y I  G+   +FKI    E   GIITI
Sbjct: 1570 LYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKI----EPVLGIITI 1625

Query: 326  QKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEP-PVFSSPLYPM 384
             KE D      + L I+  ++ +        P S T  V+I V   D   P F    Y  
Sbjct: 1626 CKEPDMTTMGQFVLSIKVTDQGSP-------PMSATAIVRISVTMSDNSHPKFIHKDYQA 1678

Query: 385  EVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET 444
            EV+E   +G  +  ++A     S S + Y + ++ D+   F I+  SGVITT K+LD E 
Sbjct: 1679 EVNENVDIGTSVILISA----ISQSTLIYEV-KDGDINGIFTINPYSGVITTQKALDYER 1733

Query: 445  NAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAM-DYETTVCENAQPGQVIQK- 502
             + + + + A  +          V I I+D NDNAP F    Y  ++ E A    +++  
Sbjct: 1734 TSSYQLIIQA--TNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSL 1791

Query: 503  ------ISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQS 556
                  I A D D  SN +        ++T    F++     +T +I T  N    +  +
Sbjct: 1792 DNSPLVIRATDAD--SNRNALLVYQIVESTAKKFFTV---DSSTGAIRTIAN-LDHETIA 1845

Query: 557  VYYLPIFIVDSGSPSLSSTNTLTIRV 582
             ++  + + DSGSP L++ + + + +
Sbjct: 1846 HFHFHVHVRDSGSPQLTAESPVEVNI 1871



 Score =  155 bits (393), Expect = 1e-37
 Identities = 150/540 (27%), Positives = 245/540 (45%), Gaps = 61/540 (11%)

Query: 67   YVGKLHSDVDKG----------DGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQA 116
            Y  +++ +VD G            ++ Y +     + IF I+  +G I   K LD E  +
Sbjct: 1676 YQAEVNENVDIGTSVILISAISQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTS 1735

Query: 117  YYTLRAQALDRLTNKPVEPESEFV-IKIQDINDNEPKFLDGPYTAGVPEMSPVGTSV--- 172
             Y L  QA    TN      +  V I+I D NDN P FL   Y+  + E +P+ + V   
Sbjct: 1736 SYQLIIQA----TNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSL 1791

Query: 173  ----VQVTATDADDPTYGNSARVVYSILQG--QPYFSVEPKTGVIKTALPNMDREAKDQY 226
                + + ATDAD      +A +VY I++   + +F+V+  TG I+T + N+D E    +
Sbjct: 1792 DNSPLVIRATDADS---NRNALLVYQIVESTAKKFFTVDSSTGAIRT-IANLDHETIAHF 1847

Query: 227  LLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKA 286
               +  +D             V + +TDVNDNPP F +  ++  +     V   V ++ A
Sbjct: 1848 HFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSA 1907

Query: 287  ADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANK 346
             D D     E+ Y +++G  L  F I    ++  G++TI+   +  +K  Y L ++ ++ 
Sbjct: 1908 TDPDSEVPPELTYSLMEG-SLDHFLI----DSNSGVLTIKN--NNLSKDHYMLIVKVSD- 1959

Query: 347  DADPRFLSLGPFSDTTTVKIIV-EDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPD 405
                     G F  T+ V I+V E +D    F+   Y   +SE       +  V A   +
Sbjct: 1960 ---------GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVG-N 2009

Query: 406  SSNSPVRYSIDRNTDLERYFNIDANSGVI-TTAKSLDRETNAIHNITVLAMESQNPSQVG 464
              N P++YSI    +    F I + SGVI TT    DRE   ++ + V A    +  +V 
Sbjct: 2010 RLNEPLKYSI---LNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVA 2066

Query: 465  RGYVAITILDINDNAPEF-AMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTT 523
            R  V + I DINDN+P F  + Y   V  +A+PG +I +++A+DKD+  NG   Y     
Sbjct: 2067 RVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVL--- 2123

Query: 524  DATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYY-LPIFIVDSGSPSLSSTNTLTIRV 582
               +  +F +  N  N    +  +  F     ++ Y + I   D G PSLS++  L I +
Sbjct: 2124 -QDDYGHFEINPNSGN----VILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI 2178



 Score =  142 bits (358), Expect = 1e-33
 Identities = 157/583 (26%), Positives = 260/583 (44%), Gaps = 81/583 (13%)

Query: 82  IKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVI 141
           ++Y LS    +  F I+  +G I   + L+  ++  Y L       +TNK  + +++  I
Sbjct: 407 VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLE------VTNKEGDLKAQVTI 460

Query: 142 KIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSI--LQGQ 199
            I+D ND+ P+F    Y A V E  PVGTSV+ V+A+D D    G +  + YSI  L   
Sbjct: 461 SIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDK---GENGYITYSIASLNLL 517

Query: 200 PYFSVEPKTGVIKTALPNMDREAKDQ-YLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDN 258
           P F +   TGVI T    +D E+  + Y  +++A D  G         +VT+ + +VNDN
Sbjct: 518 P-FVINQFTGVISTT-EELDFESSPEIYRFIVRASDW-GSPYRHESEVNVTIRIGNVNDN 574

Query: 259 PPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEME---YKIVDGDGLGIFKISVD 315
            P F + + Q  +    PV   +  + A D D     E+E   YKI+ G+ LG F ++ D
Sbjct: 575 SPLFEKVACQGVISYDFPVGGHITAVSAIDID-----ELELVKYKIISGNELGFFYLNPD 629

Query: 316 KETQEGIITIQKELDFEA--KTSYTLRIEAANKD--ADPRFLSLG---------PFSDTT 362
                G++ ++K L        ++ LRI A + +  ADP  +++           FS   
Sbjct: 630 ----SGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRE 685

Query: 363 T-----------------VKIIVED-------VDEPPVFSSPLYPMEVS--EATQVGNII 396
           T                  K+ +ED       ++    +    +P +V+  E   VG  I
Sbjct: 686 TRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANI 745

Query: 397 GTVAAHDPDSS-NSPVRYSI-DRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLA 454
             + A+D DS  N  V ++I D NTD    FNID  +G +     +DRE   ++ + +  
Sbjct: 746 LKIKAYDADSGFNGKVLFTISDGNTD--SCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803

Query: 455 MESQNPSQVGRGYVAITILDINDNAPEFAMD-YETTVCENAQPGQVIQKISAVDKDEPSN 513
            +  NP +     + I + D NDN+P F  D Y   + E++  G  I ++ A DKD  SN
Sbjct: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863

Query: 514 GHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLS 573
           G   Y  L    T+   F++    +++  I+   +   R+ ++ Y L I   D       
Sbjct: 864 GEVTYSVL----TDTQQFAI----NSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQ 915

Query: 574 STNTLTIRVCDCDADGVAQTCNAEAYVLPA--GLSTGALIAIL 614
             + +T++V   D +  +      +Y +     L  G +IA L
Sbjct: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWL 958



 Score =  133 bits (335), Expect = 6e-31
 Identities = 125/422 (29%), Positives = 198/422 (46%), Gaps = 42/422 (9%)

Query: 110 LDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVG 169
           L+RE Q  Y L  +   R   + +E  ++  I++ D+ND  P F    Y+  + E +P+ 
Sbjct: 117 LNREIQDNYLLIVKGSVR--GEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLR 174

Query: 170 TSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLV 229
           TSV QVTATDAD    G++    Y        FSV P +GVI  +   ++ + K++Y L 
Sbjct: 175 TSVAQVTATDAD---IGSNGEFYYYFKNKVDLFSVHPTSGVISLS-GRLNYDEKNRYDLE 230

Query: 230 IQAKD---MVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKA 286
           I A D    +  N G+S T  + V +  +N++ P         +VP SL      A +  
Sbjct: 231 ILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTI---HVVTHVPFSLEKEPTYAVVTV 287

Query: 287 ADADIGANAEME-YKIVDGDGLGIFKISVD-KETQEGIITIQKELDFEA-KTSYTLRIEA 343
            D D GAN E+E   IV GD L  F ++ + K   E  I  +K++D+E+    Y L ++A
Sbjct: 288 DDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQA 347

Query: 344 ANKDADPRFLSL------GPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIG 397
            +K +  +  +L       P  DT  ++           F   +Y + +SE +  G ++ 
Sbjct: 348 KDKGSPQKCSALKAVYIGNPTRDTVPIR-----------FEKEVYDVSISEFSPPGVVVA 396

Query: 398 TVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMES 457
            V    P+  +  V Y +    D   YF I+  SG+I TA+ L+     ++ + V   E 
Sbjct: 397 IVKL-SPEPID--VEYKLSPGEDAV-YFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEG 452

Query: 458 QNPSQVGRGYVAITILDINDNAPEFAMD-YETTVCENAQPGQVIQKISAVDKDEPSNGHQ 516
              +Q     V I+I D ND+ PEF    Y+  V E+   G  +  +SA DKD+  NG+ 
Sbjct: 453 DLKAQ-----VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYI 507

Query: 517 FY 518
            Y
Sbjct: 508 TY 509



 Score =  122 bits (305), Expect = 2e-27
 Identities = 124/519 (23%), Positives = 217/519 (41%), Gaps = 28/519 (5%)

Query: 73   SDVDKGD-GSIKY-ILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTN 130
            SD D  D   ++Y ILSG   +S F++D  +G I  +    +  +  Y+L     D L  
Sbjct: 2419 SDADSSDFDRLEYSILSGNDRTS-FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFT 2477

Query: 131  KPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSAR 190
               +      I++   N   P F    Y A V E    GT V+ V ATD D  TYG   +
Sbjct: 2478 STAQVH----IRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYG---Q 2530

Query: 191  VVYSILQ--GQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSV 248
            + Y+I+    +  F ++    VI T   + +   +    + ++A D     GG +   +V
Sbjct: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALD----GGGRTTFCTV 2586

Query: 249  TVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLG 308
             V + D NDN P+F    Y+ +V   +    +V +++A D D GAN+ + Y +     + 
Sbjct: 2587 RVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVS 2646

Query: 309  IFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIV 368
            +  + ++ +   G +  +   +    T  +  ++A +     +   +  +      +  +
Sbjct: 2647 VADL-LEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFL 2705

Query: 369  EDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNID 428
                  P F+   Y   ++E T +G+ + T+      +             +    F I+
Sbjct: 2706 ------PSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIE 2759

Query: 429  ANSGVITTAKSLDRETN-AIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEF-AMDY 486
              +G I   K LDRET+ A H      +       V    V I +LD+NDN P F    Y
Sbjct: 2760 QETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSY 2819

Query: 487  ETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTR 546
            +T + E    G  + ++ A+D D  +NG Q  +SL +D+         +   NT  I T 
Sbjct: 2820 DTIIMEGMPVGTKLTQVRAIDMDWGANG-QVTYSLHSDSQPEKVMEAFNIDSNTGWISTL 2878

Query: 547  RNGFRRQEQSVYYLPIFIVDSGSP-SLSSTNTLTIRVCD 584
            ++    +    +   +   D G   SLSST  +++RV D
Sbjct: 2879 KD-LDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTD 2916



 Score =  117 bits (294), Expect = 3e-26
 Identities = 139/542 (25%), Positives = 244/542 (45%), Gaps = 49/542 (9%)

Query: 50   VWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKR 109
            V+    +L  Y+G + L V     D +     + Y L  EG+   F+ID N+G +  T +
Sbjct: 1887 VFETILLLPTYVGVEVLKVSATDPDSEVPP-ELTYSLM-EGSLDHFLIDSNSGVL--TIK 1942

Query: 110  LDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVG 169
             +   + +Y L    + ++++      S   I +++  D+   F    Y+  + E +   
Sbjct: 1943 NNNLSKDHYML----IVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNI 1998

Query: 170  TSVVQVTATDADDPTYGNSAR--VVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYL 227
            T V  V A        GN     + YSIL     F ++  +GVI+T     DRE ++ Y 
Sbjct: 1999 TKVAIVNAV-------GNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYE 2051

Query: 228  LVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAA 287
            LV++A   +           V V + D+NDN P F    Y   V       +++ ++ A 
Sbjct: 2052 LVVEASRELDHLR--VARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAI 2109

Query: 288  DADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFE-AKTSYTLRIEAANK 346
            D D G N E+ Y + D    G F+I+ +     G + +++  + + +   Y + I A  K
Sbjct: 2110 DKDKGPNGEVTYVLQDD--YGHFEINPNS----GNVILKEAFNSDLSNIEYGVTILA--K 2161

Query: 347  DADPRFLSLGPFSDTTTVKIIVEDVDEP-PVFSSPLYPMEVSEATQVGNIIGTVAAHDPD 405
            D     LS       T+V++ +  V++  PVF  P Y   V+E  ++   I ++ A  P+
Sbjct: 2162 DGGKPSLS-------TSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE 2214

Query: 406  SSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGR 465
                 + Y I  + D  + FNID ++GV+     LD E  + + +T+ A ++   +   R
Sbjct: 2215 GQG--IIYIII-DGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGA---R 2268

Query: 466  GYVAITIL--DINDNAPEFAMD-YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLT 522
              V + +L  D+NDN P F    Y TT+ E +  G  + ++ ++D D  +N    ++ + 
Sbjct: 2269 AEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENN-KMVHYQIV 2327

Query: 523  TDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRV 582
             D  N+ ++   D+  ++  ILT R       Q    L +  +DSG PSLSS   + I +
Sbjct: 2328 QDTYNSTDYFHIDS--SSGLILTARMLDHELVQHCT-LKVRSIDSGFPSLSSEVLVHIYI 2384

Query: 583  CD 584
             D
Sbjct: 2385 SD 2386



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 70/295 (23%), Positives = 120/295 (40%), Gaps = 31/295 (10%)

Query: 296 EMEYKIVDGDGLGIFKISVDKETQEGIITIQKE------LDFEAKTSYTLRIEAANKDAD 349
           +++Y+IV GD  G FK           + I+ +      L+ E + +Y L ++ + +  D
Sbjct: 78  DIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGED 137

Query: 350 PRFLSLGPFSDTTTVKIIVEDV-DEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPD-SS 407
                       T V I V D+ D  P+FS   Y + ++E+T +   +  V A D D  S
Sbjct: 138 --------LEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189

Query: 408 NSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAME-------SQNP 460
           N    Y      DL   F++   SGVI+ +  L+ +    +++ +LA++       +   
Sbjct: 190 NGEFYYYFKNKVDL---FSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGV 246

Query: 461 SQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFS 520
           S   + YV I    IN++AP   +          +P   +  ++  D D+ +NG     S
Sbjct: 247 SSTAKLYVHIE--RINEHAPTIHVVTHVPFSLEKEPTYAV--VTVDDLDDGANGEIESVS 302

Query: 521 LTTDATNNHNFSLKDNK-DNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSS 574
           +      +  F  K+ K  N   I  R+          Y L +   D GSP   S
Sbjct: 303 IVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCS 357



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 33/122 (27%), Positives = 54/122 (44%), Gaps = 16/122 (13%)

Query: 468 VAITILDINDNAPEFA-MDYETTVCENAQPGQVIQKISAVDKDEPSNGH-QFYFSLTTDA 525
           V I +LD+ND  P F+   Y  T+ E+      + +++A D D  SNG   +YF    D 
Sbjct: 144 VNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDL 203

Query: 526 TNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDS-----GSPSLSSTNTLTI 580
            + H          T+ +++        E++ Y L I  VD      G+  +SST  L +
Sbjct: 204 FSVH---------PTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYV 254

Query: 581 RV 582
            +
Sbjct: 255 HI 256


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,862,063
Number of Sequences: 37866
Number of extensions: 1294925
Number of successful extensions: 9120
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 191
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 3095
Number of HSP's gapped (non-prelim): 826
length of query: 785
length of database: 18,247,518
effective HSP length: 110
effective length of query: 675
effective length of database: 14,082,258
effective search space: 9505524150
effective search space used: 9505524150
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.