Search of human proteins with 158303333

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|158303333 synaptopodin isoform B [Homo sapiens]
         (685 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|158303333 synaptopodin isoform B [Homo sapiens]                   1371   0.0  
gi|40353727 synaptopodin isoform A [Homo sapiens]                    1349   0.0  
gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]             154   2e-37
gi|50301232 synaptopodin 2-like isoform b [Homo sapiens]              154   2e-37
gi|193083185 synaptopodin 2 isoform b [Homo sapiens]                  113   7e-25
gi|193083191 synaptopodin 2 isoform c [Homo sapiens]                  102   9e-22
gi|193083183 synaptopodin 2 isoform a [Homo sapiens]                  101   3e-21
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    81   4e-15
gi|163965366 nascent polypeptide-associated complex alpha subuni...    75   3e-13
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         67   4e-11
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   66   9e-11
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   66   9e-11
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   66   9e-11
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    66   9e-11
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    66   1e-10
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    65   3e-10
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    63   1e-09
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        61   3e-09
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]         59   1e-08
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         57   7e-08
gi|18079216 CASK interacting protein 1 [Homo sapiens]                  55   2e-07
gi|91982772 mucin 17 [Homo sapiens]                                    55   2e-07
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     55   3e-07
gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapi...    54   6e-07
gi|239749989 PREDICTED: otogelin isoform 2 [Homo sapiens]              54   6e-07
gi|239749987 PREDICTED: otogelin isoform 1 [Homo sapiens]              54   6e-07
gi|239743293 PREDICTED: mucin 12 [Homo sapiens]                        53   8e-07
gi|116284392 mucin 2 precursor [Homo sapiens]                          53   1e-06
gi|239755545 PREDICTED: otogelin isoform 1 [Homo sapiens]              53   1e-06
gi|239755543 PREDICTED: otogelin isoform 2 [Homo sapiens]              53   1e-06

>gi|158303333 synaptopodin isoform B [Homo sapiens]
          Length = 685

 Score = 1371 bits (3548), Expect = 0.0
 Identities = 685/685 (100%), Positives = 685/685 (100%)

Query: 1   MEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPA 60
           MEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPA
Sbjct: 1   MEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPA 60

Query: 61  EVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSE 120
           EVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSE
Sbjct: 61  EVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSE 120

Query: 121 AQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSS 180
           AQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSS
Sbjct: 121 AQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSS 180

Query: 181 RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTA 240
           RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTA
Sbjct: 181 RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTA 240

Query: 241 RPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMM 300
           RPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMM
Sbjct: 241 RPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMM 300

Query: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP 360
           GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP
Sbjct: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP 360

Query: 361 ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEP 420
           ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEP
Sbjct: 361 ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEP 420

Query: 421 FALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKG 480
           FALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKG
Sbjct: 421 FALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKG 480

Query: 481 AELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP 540
           AELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP
Sbjct: 481 AELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP 540

Query: 541 PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVP 600
           PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVP
Sbjct: 541 PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVP 600

Query: 601 NLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQ 660
           NLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQ
Sbjct: 601 NLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQ 660

Query: 661 APRPSFSTRNAGIEAQVWKPSFCFK 685
           APRPSFSTRNAGIEAQVWKPSFCFK
Sbjct: 661 APRPSFSTRNAGIEAQVWKPSFCFK 685


>gi|40353727 synaptopodin isoform A [Homo sapiens]
          Length = 903

 Score = 1349 bits (3491), Expect = 0.0
 Identities = 676/676 (100%), Positives = 676/676 (100%)

Query: 1   MEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPA 60
           MEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPA
Sbjct: 1   MEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPA 60

Query: 61  EVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSE 120
           EVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSE
Sbjct: 61  EVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSE 120

Query: 121 AQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSS 180
           AQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSS
Sbjct: 121 AQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSS 180

Query: 181 RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTA 240
           RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTA
Sbjct: 181 RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTA 240

Query: 241 RPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMM 300
           RPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMM
Sbjct: 241 RPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMM 300

Query: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP 360
           GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP
Sbjct: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP 360

Query: 361 ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEP 420
           ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEP
Sbjct: 361 ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEP 420

Query: 421 FALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKG 480
           FALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKG
Sbjct: 421 FALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKG 480

Query: 481 AELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP 540
           AELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP
Sbjct: 481 AELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP 540

Query: 541 PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVP 600
           PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVP
Sbjct: 541 PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVP 600

Query: 601 NLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQ 660
           NLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQ
Sbjct: 601 NLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQ 660

Query: 661 APRPSFSTRNAGIEAQ 676
           APRPSFSTRNAGIEAQ
Sbjct: 661 APRPSFSTRNAGIEAQ 676



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 68/239 (28%), Positives = 92/239 (38%), Gaps = 31/239 (12%)

Query: 441 SPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSS 500
           SP    ++ P   S   SPR  AK  P+P+ +   A   G E   RR+S     +  S  
Sbjct: 638 SPPYGGDISPVSPSRAWSPR--AKQAPRPSFSTRNA---GIEAQDRRES-----LPTSPP 687

Query: 501 HTPELARCPSPTMSL--PSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPEN-GVLRP 557
            TP  +R PS       P  W+     PG     S  P   PP  +   +   +   LRP
Sbjct: 688 WTPGASRPPSSLDGWVSPGPWE-----PGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRP 742

Query: 558 EPTKQPPYQLRPSLFVLSPIKEPAK--VSPRAASPA--KPSSLDLVPNLPKGALPPSPAL 613
           E   +PP +   +L   + I    +   SPR+A     +P S    P  P    PP P +
Sbjct: 743 ETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRM 802

Query: 614 PRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRA--KQAPRPSFSTRN 670
             P  + PG    PG  +  P   SP       P  PS   SPR+     PRP    R+
Sbjct: 803 RSPQPARPGSAAVPGA-AFAPIPRSP------LPAGPSSCTSPRSPLPAPPRPFLYRRS 854


>gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]
          Length = 977

 Score =  154 bits (390), Expect = 2e-37
 Identities = 156/518 (30%), Positives = 216/518 (41%), Gaps = 76/518 (14%)

Query: 233 PSVVNRTARPF--GIQA--PGGTSQMER--SPMLERRHFGEKAPAPQPPSLPDRSPRPQR 286
           PS+ NR+ARPF  G+Q   P  TS + R  +P       G  +PAP PP L  + P P  
Sbjct: 461 PSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAP-PPFLSSQGPTPLP 519

Query: 287 HIMSRSPMVERRMMGQRSPASE--------------RRPL--GNFTAPPTYTETLSTAPL 330
              S  P          +P S                RP+  G    PP      +    
Sbjct: 520 SFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTST 579

Query: 331 ASWVRSPPSYSVLYPSS--------DPKSSHLKGQAVPASKTGILEESMARRGSRKSMF- 381
           AS   S P      P +        +P S+  +  +VPA++TGIL+E+  RRG+RK MF 
Sbjct: 580 ASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEA-RRRGTRKQMFR 638

Query: 382 TFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRD-RA 440
              E+ K +PNP+LL LVQ  DEK R     E G EE+  +LGAEA NF Q    R  + 
Sbjct: 639 PGKEETKNSPNPELLSLVQNLDEKPR-AGGAESGPEEDALSLGAEACNFMQPVGARSYKT 697

Query: 441 SPAAAEEVVPEWASCLKSPRIQAKPKP----KPNQNLSEA-----------------SGK 479
            P    +  P  A     P     P P     P++ L +                   G+
Sbjct: 698 LPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGR 757

Query: 480 GAELYARRQSRMEKYVIESSSHTPELA---RCPSPTMSLPSSWKYPTNAPGAFRVASR-- 534
           G EL+A+RQSR ++YV+E +   P L    R PSPT SLP SWKY  N      +A    
Sbjct: 758 GGELFAKRQSRADRYVVEGTP-GPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPL 816

Query: 535 -SP-----ARTPPASLYHG--YLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPR 586
            SP     ART P +   G    P+ G+   +  +  PYQL+ ++F    +  P    P 
Sbjct: 817 LSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEV--PPTPGPI 874

Query: 587 AASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDIS 646
           A+   K + +  +      A  P+     P+  +P   T+  +   +    S P      
Sbjct: 875 ASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAP 934

Query: 647 PVSPSRAW----SPRAKQAPRPSFSTRNAGIEAQVWKP 680
           P    R      S    Q  RP FS    G++A VW+P
Sbjct: 935 PPEAPRGLGASPSSCGFQVARPRFSATRTGLQAHVWRP 972



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 124/549 (22%), Positives = 185/549 (33%), Gaps = 81/549 (14%)

Query: 189 SSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAP 248
           S+  LID   N LV++       R A   P +  S     +  P S ++       +  P
Sbjct: 68  SAMSLIDASGNQLVLTVQ-----RLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQP 122

Query: 249 GGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASE 308
                + RSP     ++GE       P+  ++  RP+R   +R               S 
Sbjct: 123 LQPGSL-RSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSP 181

Query: 309 RRPLGNFTAPPTYTETLSTAPLASW-----VRSPPSYSVLYPSSDPKSS-HL-------- 354
             P      PP+  ++  ++P  SW     ++ PP+ ++L P    +   HL        
Sbjct: 182 AEPAPTIPGPPSQGDSRVSSP--SWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVP 239

Query: 355 -------------KGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQT 401
                        K +     +   L+E   +    K   T        PNP    ++  
Sbjct: 240 HPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCR-TIASLLTAAPNPHSKGVLMF 298

Query: 402 ADEKRRQRDQ----------GEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPE 451
             +KRRQR +             G EEE        S   +E       S A +     +
Sbjct: 299 --KKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAF-----SDARSLTNQSD 351

Query: 452 WAS-CLKSPRIQAKPKPKPNQN------LSEASGKGAELYARRQSRMEKYVIESSSHTPE 504
           W S  L     +A  +    Q       LSE SG+G +L+ +++ R       + S T E
Sbjct: 352 WDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQR-------ADSSTQE 404

Query: 505 LARCPSPTMSLPSSWKYP---TNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPT- 560
           LAR     M      + P    +AP    V   SP   P AS    + P  G   P P+ 
Sbjct: 405 LARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVAS-PRPFQPGGGAPTPAPSI 463

Query: 561 -KQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLP-----KGALP-PSPAL 613
             +      P L    P        P A   A  S   L P  P     +G  P PS   
Sbjct: 464 FNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTS 523

Query: 614 PRPSRSSPGLYTSPGQDSLQPTAVSPPY-GGDISPVSPSRAWSPRAKQAPRPSFSTRNAG 672
             PS +      S  + S   TA S  Y      PV+P  A  P A  +     ST +  
Sbjct: 524 GVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIF 583

Query: 673 IEAQVWKPS 681
           + A + +PS
Sbjct: 584 LSAPL-RPS 591


>gi|50301232 synaptopodin 2-like isoform b [Homo sapiens]
          Length = 753

 Score =  154 bits (390), Expect = 2e-37
 Identities = 156/518 (30%), Positives = 216/518 (41%), Gaps = 76/518 (14%)

Query: 233 PSVVNRTARPF--GIQA--PGGTSQMER--SPMLERRHFGEKAPAPQPPSLPDRSPRPQR 286
           PS+ NR+ARPF  G+Q   P  TS + R  +P       G  +PAP PP L  + P P  
Sbjct: 237 PSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAP-PPFLSSQGPTPLP 295

Query: 287 HIMSRSPMVERRMMGQRSPASE--------------RRPL--GNFTAPPTYTETLSTAPL 330
              S  P          +P S                RP+  G    PP      +    
Sbjct: 296 SFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTST 355

Query: 331 ASWVRSPPSYSVLYPSS--------DPKSSHLKGQAVPASKTGILEESMARRGSRKSMF- 381
           AS   S P      P +        +P S+  +  +VPA++TGIL+E+  RRG+RK MF 
Sbjct: 356 ASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEA-RRRGTRKQMFR 414

Query: 382 TFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRD-RA 440
              E+ K +PNP+LL LVQ  DEK R     E G EE+  +LGAEA NF Q    R  + 
Sbjct: 415 PGKEETKNSPNPELLSLVQNLDEKPR-AGGAESGPEEDALSLGAEACNFMQPVGARSYKT 473

Query: 441 SPAAAEEVVPEWASCLKSPRIQAKPKP----KPNQNLSEA-----------------SGK 479
            P    +  P  A     P     P P     P++ L +                   G+
Sbjct: 474 LPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGR 533

Query: 480 GAELYARRQSRMEKYVIESSSHTPELA---RCPSPTMSLPSSWKYPTNAPGAFRVASR-- 534
           G EL+A+RQSR ++YV+E +   P L    R PSPT SLP SWKY  N      +A    
Sbjct: 534 GGELFAKRQSRADRYVVEGTP-GPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPL 592

Query: 535 -SP-----ARTPPASLYHG--YLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPR 586
            SP     ART P +   G    P+ G+   +  +  PYQL+ ++F    +  P    P 
Sbjct: 593 LSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEV--PPTPGPI 650

Query: 587 AASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDIS 646
           A+   K + +  +      A  P+     P+  +P   T+  +   +    S P      
Sbjct: 651 ASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAP 710

Query: 647 PVSPSRAW----SPRAKQAPRPSFSTRNAGIEAQVWKP 680
           P    R      S    Q  RP FS    G++A VW+P
Sbjct: 711 PPEAPRGLGASPSSCGFQVARPRFSATRTGLQAHVWRP 748



 Score = 36.6 bits (83), Expect = 0.079
 Identities = 61/221 (27%), Positives = 82/221 (37%), Gaps = 21/221 (9%)

Query: 473 LSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYP---TNAPGAF 529
           LSE SG+G +L+ +++ R       + S T ELAR     M      + P    +AP   
Sbjct: 156 LSEVSGRGVQLFEQQRQR-------ADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEA 208

Query: 530 RVASRSPARTPPASLYHGYLPENGVLRPEPT--KQPPYQLRPSLFVLSPIKEPAKVSPRA 587
            V   SP   P AS    + P  G   P P+   +      P L    P        P A
Sbjct: 209 AVLPPSPLPAPVAS-PRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLA 267

Query: 588 ASPAKPSSLDLVPNLP-----KGALP-PSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPY 641
              A  S   L P  P     +G  P PS     PS +      S  + S   TA S  Y
Sbjct: 268 PKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLY 327

Query: 642 -GGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVWKPS 681
                 PV+P  A  P A  +     ST +  + A + +PS
Sbjct: 328 IPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPL-RPS 367


>gi|193083185 synaptopodin 2 isoform b [Homo sapiens]
          Length = 1093

 Score =  113 bits (282), Expect = 7e-25
 Identities = 135/494 (27%), Positives = 195/494 (39%), Gaps = 139/494 (28%)

Query: 311  PLGNFTAPPTYTETLS---------TAPLASWVRSPP-------SYSVLYPSSDPKSSHL 354
            P+ +F APP Y+             ++P+A   + PP       S    Y SS+  +S  
Sbjct: 612  PIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRD 671

Query: 355  KGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEV 414
            +  +VPA +TGIL+E+  RR + K MFTF E PKV+PNP+LL L+Q ++ KR     G+ 
Sbjct: 672  ERISVPAKRTGILQEAK-RRSTTKPMFTFKE-PKVSPNPELLSLLQNSEGKRGTGAGGDS 729

Query: 415  GVEEEPFALGAEASNFQQEPAPRDRASPAAAEE-------------VVPEWASCLKSPRI 461
            G EE+  +LGAEA NF Q  + + +  P  A +             V P W+  +   + 
Sbjct: 730  GPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQP 789

Query: 462  QAKPKPKPNQNLSEASGKGAELY---ARRQSRME--------KYVIESSSHTPELARCPS 510
             A P   P++    +S K A+     AR  S +         +  + S ++TP+      
Sbjct: 790  PAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPK------ 843

Query: 511  PTMSLPSSWKYPTNAPG------------------------------------AFRVASR 534
            PT+S P+       A G                                    A R  S 
Sbjct: 844  PTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSP 903

Query: 535  SPA-----------RTPPASLY---HGYLPENGVLRPEPTKQPP---------------- 564
            +P+           R PP   Y   H        L+ +P+   P                
Sbjct: 904  TPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALD 963

Query: 565  ------YQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPA------ 612
                  YQL  SLF   P  +     P+ +S    S+L +     K ALPP P       
Sbjct: 964  VMKHQPYQLNASLFTFQP-PDAKDGLPQKSSVKVNSALAM-----KQALPPRPVNAASPT 1017

Query: 613  -LPRPSRSSPGLYTSPGQ---DSLQPTAVSP-PYGGDISPVSPSRAWSPRAKQAPRPSFS 667
             +   S  S   YTSP     ++  P + SP P G   SP   S + S     APRP FS
Sbjct: 1018 NVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFV--APRPKFS 1075

Query: 668  TRNAGIEAQVWKPS 681
             + +G+  QVWKPS
Sbjct: 1076 AKKSGVTIQVWKPS 1089



 Score = 36.6 bits (83), Expect = 0.079
 Identities = 41/194 (21%), Positives = 71/194 (36%), Gaps = 26/194 (13%)

Query: 473 LSEASGKGAELYARRQSRMEKYVIESSSH----TPELARCPSPTMSLPSSWKYPTNAPGA 528
           L + +GKGA ++A+R+ RM++   +        TP   +  + T  L ++  Y      +
Sbjct: 484 LPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEES 543

Query: 529 FRV----------ASRSPARTPPASLYHG---------YLPENGVLRPEP--TKQPPYQL 567
            R            S      P  + + G          +P N   +P P    QP    
Sbjct: 544 VRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPATPF 603

Query: 568 RPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSR-SSPGLYTS 626
            P+  + SPI +     P +A    P +     + P       P  P+P+  S P  Y S
Sbjct: 604 SPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDS 663

Query: 627 PGQDSLQPTAVSPP 640
             + + +   +S P
Sbjct: 664 SERIASRDERISVP 677


>gi|193083191 synaptopodin 2 isoform c [Homo sapiens]
          Length = 1109

 Score =  102 bits (255), Expect = 9e-22
 Identities = 131/490 (26%), Positives = 191/490 (38%), Gaps = 139/490 (28%)

Query: 311  PLGNFTAPPTYTETLS---------TAPLASWVRSPP-------SYSVLYPSSDPKSSHL 354
            P+ +F APP Y+             ++P+A   + PP       S    Y SS+  +S  
Sbjct: 612  PIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRD 671

Query: 355  KGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEV 414
            +  +VPA +TGIL+E+  RR + K MFTF E PKV+PNP+LL L+Q ++ KR     G+ 
Sbjct: 672  ERISVPAKRTGILQEAK-RRSTTKPMFTFKE-PKVSPNPELLSLLQNSEGKRGTGAGGDS 729

Query: 415  GVEEEPFALGAEASNFQQEPAPRDRASPAAAEE-------------VVPEWASCLKSPRI 461
            G EE+  +LGAEA NF Q  + + +  P  A +             V P W+  +   + 
Sbjct: 730  GPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQP 789

Query: 462  QAKPKPKPNQNLSEASGKGAELY---ARRQSRME--------KYVIESSSHTPELARCPS 510
             A P   P++    +S K A+     AR  S +         +  + S ++TP+      
Sbjct: 790  PAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPK------ 843

Query: 511  PTMSLPSSWKYPTNAPG------------------------------------AFRVASR 534
            PT+S P+       A G                                    A R  S 
Sbjct: 844  PTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSP 903

Query: 535  SPA-----------RTPPASLY---HGYLPENGVLRPEPTKQPP---------------- 564
            +P+           R PP   Y   H        L+ +P+   P                
Sbjct: 904  TPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALD 963

Query: 565  ------YQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPA------ 612
                  YQL  SLF   P  +     P+ +S    S+L +     K ALPP P       
Sbjct: 964  VMKHQPYQLNASLFTFQP-PDAKDGLPQKSSVKVNSALAM-----KQALPPRPVNAASPT 1017

Query: 613  -LPRPSRSSPGLYTSPGQ---DSLQPTAVSP-PYGGDISPVSPSRAWSPRAKQAPRPSFS 667
             +   S  S   YTSP     ++  P + SP P G   SP   S + S     APRP FS
Sbjct: 1018 NVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFV--APRPKFS 1075

Query: 668  TRNAGIEAQV 677
             + +G+  QV
Sbjct: 1076 AKKSGVTIQV 1085



 Score = 36.6 bits (83), Expect = 0.079
 Identities = 41/194 (21%), Positives = 71/194 (36%), Gaps = 26/194 (13%)

Query: 473 LSEASGKGAELYARRQSRMEKYVIESSSH----TPELARCPSPTMSLPSSWKYPTNAPGA 528
           L + +GKGA ++A+R+ RM++   +        TP   +  + T  L ++  Y      +
Sbjct: 484 LPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEES 543

Query: 529 FRV----------ASRSPARTPPASLYHG---------YLPENGVLRPEP--TKQPPYQL 567
            R            S      P  + + G          +P N   +P P    QP    
Sbjct: 544 VRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPATPF 603

Query: 568 RPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSR-SSPGLYTS 626
            P+  + SPI +     P +A    P +     + P       P  P+P+  S P  Y S
Sbjct: 604 SPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDS 663

Query: 627 PGQDSLQPTAVSPP 640
             + + +   +S P
Sbjct: 664 SERIASRDERISVP 677


>gi|193083183 synaptopodin 2 isoform a [Homo sapiens]
          Length = 1261

 Score =  101 bits (251), Expect = 3e-21
 Identities = 130/489 (26%), Positives = 190/489 (38%), Gaps = 139/489 (28%)

Query: 311  PLGNFTAPPTYTETLS---------TAPLASWVRSPP-------SYSVLYPSSDPKSSHL 354
            P+ +F APP Y+             ++P+A   + PP       S    Y SS+  +S  
Sbjct: 612  PIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRD 671

Query: 355  KGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEV 414
            +  +VPA +TGIL+E+  RR + K MFTF E PKV+PNP+LL L+Q ++ KR     G+ 
Sbjct: 672  ERISVPAKRTGILQEAK-RRSTTKPMFTFKE-PKVSPNPELLSLLQNSEGKRGTGAGGDS 729

Query: 415  GVEEEPFALGAEASNFQQEPAPRDRASPAAAEE-------------VVPEWASCLKSPRI 461
            G EE+  +LGAEA NF Q  + + +  P  A +             V P W+  +   + 
Sbjct: 730  GPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQP 789

Query: 462  QAKPKPKPNQNLSEASGKGAELY---ARRQSRME--------KYVIESSSHTPELARCPS 510
             A P   P++    +S K A+     AR  S +         +  + S ++TP+      
Sbjct: 790  PAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPK------ 843

Query: 511  PTMSLPSSWKYPTNAPG------------------------------------AFRVASR 534
            PT+S P+       A G                                    A R  S 
Sbjct: 844  PTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSP 903

Query: 535  SPA-----------RTPPASLY---HGYLPENGVLRPEPTKQPP---------------- 564
            +P+           R PP   Y   H        L+ +P+   P                
Sbjct: 904  TPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALD 963

Query: 565  ------YQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPA------ 612
                  YQL  SLF   P  +     P+ +S    S+L +     K ALPP P       
Sbjct: 964  VMKHQPYQLNASLFTFQP-PDAKDGLPQKSSVKVNSALAM-----KQALPPRPVNAASPT 1017

Query: 613  -LPRPSRSSPGLYTSPGQ---DSLQPTAVSP-PYGGDISPVSPSRAWSPRAKQAPRPSFS 667
             +   S  S   YTSP     ++  P + SP P G   SP   S + S     APRP FS
Sbjct: 1018 NVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFV--APRPKFS 1075

Query: 668  TRNAGIEAQ 676
             + +G+  Q
Sbjct: 1076 AKKSGVTIQ 1084



 Score = 36.6 bits (83), Expect = 0.079
 Identities = 41/194 (21%), Positives = 71/194 (36%), Gaps = 26/194 (13%)

Query: 473 LSEASGKGAELYARRQSRMEKYVIESSSH----TPELARCPSPTMSLPSSWKYPTNAPGA 528
           L + +GKGA ++A+R+ RM++   +        TP   +  + T  L ++  Y      +
Sbjct: 484 LPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEES 543

Query: 529 FRV----------ASRSPARTPPASLYHG---------YLPENGVLRPEP--TKQPPYQL 567
            R            S      P  + + G          +P N   +P P    QP    
Sbjct: 544 VRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPATPF 603

Query: 568 RPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSR-SSPGLYTS 626
            P+  + SPI +     P +A    P +     + P       P  P+P+  S P  Y S
Sbjct: 604 SPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDS 663

Query: 627 PGQDSLQPTAVSPP 640
             + + +   +S P
Sbjct: 664 SERIASRDERISVP 677


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 152/655 (23%), Positives = 233/655 (35%), Gaps = 102/655 (15%)

Query: 22   EEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLT 81
            EE+PL+   +E+          LS   E   +SP P  + +  P  ++  +    +  L+
Sbjct: 436  EEMPLLPPPEESP---------LSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLS 486

Query: 82   TPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADG 141
             P   S  +PP  +   +PP    P+S P S ++++            P S P     + 
Sbjct: 487  RPLEESPLSPPPEESPLSPP----PESSPFSPLEES------------PLSPP-----EE 525

Query: 142  QPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTL 201
             P +PA E   S        +P    S  S     +P+S PP +  +S        P   
Sbjct: 526  SPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSP------PPEES 579

Query: 202  VVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLE 261
             +S   E S  +     ++++     +   PP           +  P   S++   P   
Sbjct: 580  PMSPPPEESPMSPPPEASRLFPPFEESPLSPP------PEESPLSPPPEASRLSPPP--- 630

Query: 262  RRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLG-----NFT 316
                 E +P   PP     SP P+   +S  P+V R      SP  E  PL      + T
Sbjct: 631  -----EDSPMSPPPEESPMSPPPEVSRLSPLPVVSR-----LSPPPEESPLSPPPEESPT 680

Query: 317  APPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGIL----EESMA 372
            +PP     LS  P  S    PP  S   P+S P    L   ++P  ++ +L    E  + 
Sbjct: 681  SPPPEASRLSPPPEDSPTSPPPEDS---PASPPPEDSL--MSLPLEESPLLPLPEEPQLC 735

Query: 373  RRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGE---VGVEEEPFALGAEASN 429
             R     +    E+P ++P P+   L   A+E        E     V EEP  L  +A  
Sbjct: 736  PRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPH-LSPQAEG 794

Query: 430  FQQEPAPRD-RASPAAAE---EVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYA 485
                P P +   SP   E     VPE   CL     ++   P+  +       + + L  
Sbjct: 795  PHLSPQPEELHLSPQTEEPHLSPVPE-EPCLSPQPEESHLSPQSEEPCLSPRPEESHL-- 851

Query: 486  RRQSRMEKYVIESSSHTP--ELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPAS 543
                 +EK  +      P  E  +CP+P   LP    +P     +       PA + P  
Sbjct: 852  --SPELEKPPLSPRPEKPPEEPGQCPAPE-ELP---LFPPPGEPSLSPLLGEPALSEPGE 905

Query: 544  LYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLV--PN 601
                 LPE   L   P+ +P   L P L    P+  P      AA+P   S L  +  P 
Sbjct: 906  PPLSPLPEE--LPLSPSGEP--SLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPF 961

Query: 602  LPKGALPPSPALPRPSRSSP------GLYTSPGQDSLQPTAVSPPYGGDISPVSP 650
              KG   P   L  P   +P         T P  + + P  + P  G  + P SP
Sbjct: 962  GAKGDSDPESPLAAPILETPISPPPEANCTDP--EPVPPMILPPSPGSPVGPASP 1014



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 156/696 (22%), Positives = 225/696 (32%), Gaps = 119/696 (17%)

Query: 22   EEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLT 81
            E  PL    +E+        L  S   EA + SP P  + +  P  +   +    ++ L 
Sbjct: 541  EASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLF 600

Query: 82   TPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADG 141
             P   S  +PP  +   +PP      S P      +    + P +     S+ S L    
Sbjct: 601  PPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVS 660

Query: 142  QPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTL 201
            +   P EE   S    +  ++P    S  S      P+S PP     S        P   
Sbjct: 661  RLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASP------PPEDS 714

Query: 202  VVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLE 261
            ++S   E S                  L + P +  R+  P              SP  E
Sbjct: 715  LMSLPLEESPL--------------LPLPEEPQLCPRSEGP------------HLSPRPE 748

Query: 262  RRHFGEKAPAPQPPSL------PDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNF 315
              H    +P P+ P L      P  SP+P+   +   P           P    +P    
Sbjct: 749  EPHL---SPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELH 805

Query: 316  TAPPTYTETLSTAPLASWVRSPPSYSVLYPSSD-------PKSSHLKGQAVPASKTGILE 368
             +P T    LS  P    +   P  S L P S+       P+ SHL  +         LE
Sbjct: 806  LSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPE---------LE 856

Query: 369  ESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEE--EPFALGAE 426
            +        K      E+P   P P+ L L     E       GE  + E  EP  L   
Sbjct: 857  KPPLSPRPEKP----PEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEP-PLSPL 911

Query: 427  ASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYAR 486
                   P+     SP   + + P+      SP I A   P  +         GA+  + 
Sbjct: 912  PEELPLSPSGEPSLSP---QLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSD 968

Query: 487  RQSRMEKYVIESSSHTPELARC----PSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPA 542
             +S +   ++E+    P  A C    P P M LP S   P        +    P  +P  
Sbjct: 969  PESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSP-- 1026

Query: 543  SLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPI--------------KEPAKVSPRAA 588
             L H  +P+N    P     PP         LSPI               E  KVS    
Sbjct: 1027 LLQHSLVPQNS---PPSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPEC 1083

Query: 589  SPAKPSSLDLVPNLPKGAL-----PPSPAL-----------PRPSRSSPGLYTSPGQ--D 630
               +PS+   +P+ P G L      P+PAL           P     +PG    PGQ   
Sbjct: 1084 PALEPSATSPLPS-PMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPEPGQTPG 1142

Query: 631  SL------QPTAVSPPYGGDISPVSPSRAWSPRAKQ 660
            SL       P  + P    +++PV+P   + P  KQ
Sbjct: 1143 SLASELKGSPVLLDPE---ELAPVTPMEVY-PECKQ 1174



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 53/186 (28%), Positives = 67/186 (36%), Gaps = 24/186 (12%)

Query: 511 PTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPS 570
           P +  P + + P   P        SP   PP        PE   L P P + P   L  +
Sbjct: 428 PQLEAPLNEEMPLLPP-----PEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEA 482

Query: 571 LFVLSPIKEPAKVSPRAASPAKP-------SSLDLVPNLPKGALPPSPAL-------PRP 616
           L +  P++E     P   SP  P       S L+  P  P    PPSPAL       P  
Sbjct: 483 LHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEA 542

Query: 617 SRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQ 676
           S  SP    SP     +    SPP   + S +SP    SP    +P P  S  +   EA 
Sbjct: 543 SPLSPPFEESPLSPPPEELPTSPP--PEASRLSPPPEESP---MSPPPEESPMSPPPEAS 597

Query: 677 VWKPSF 682
              P F
Sbjct: 598 RLFPPF 603



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 87/373 (23%), Positives = 135/373 (36%), Gaps = 57/373 (15%)

Query: 57   PPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPP----ATVVPQSLPLS 112
            PPPA+  +P+   + ++  P +  T P +     PP T   Q PP      + P+SLP  
Sbjct: 2352 PPPAQALAPSPPSHPDIFRPGS-YTDPYAQ----PPLTPRPQPPPPESCCALPPRSLPSD 2406

Query: 113  SIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSR 172
               +  +  Q  S+   P + P  L A+    +P      S    D  S P +   +   
Sbjct: 2407 PFSRVPASPQSQSSSQSPLT-PRPLSAEAFCPSPVTPRFQSP---DPYSRPPSRPQSRDP 2462

Query: 173  EATLI--PSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLA 230
             A L   P  +PP   F + SL           +     +G   A  P     E+H   A
Sbjct: 2463 FAPLHKPPRPQPPEVAFKAGSL-----------AHTSLGAGGFPAALPAGPAGELH---A 2508

Query: 231  KPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGE-------KAPAPQPPSLPDRSPR 283
            K PS      +P       GT     +P   R  F +       K P PQP   P   P 
Sbjct: 2509 KVPS-----GQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPP---PH 2560

Query: 284  PQRHIMSRSPMVERRMMGQRSPASER-RPLGNFTAPPTYT--ETLSTAPLASWVRSPPSY 340
                     P + +      + A+    P G+   P + +  E+   +PL      PP  
Sbjct: 2561 GINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPP-- 2618

Query: 341  SVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKV--TPNPDLLDL 398
                P+ D    +L   A  + ++GI      R      M + +   ++  T +P +  L
Sbjct: 2619 ----PAPDGSLPYLSHGA--SQRSGITSPVEKREDPGTGMGSSLATAELPGTQDPGMSGL 2672

Query: 399  VQTADEKRRQRDQ 411
             QT  EK+RQR +
Sbjct: 2673 SQTELEKQRQRQR 2685



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 29/109 (26%), Positives = 42/109 (38%), Gaps = 16/109 (14%)

Query: 550  PENGVLR-----PEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPK 604
            P+ G L+     P P   P     P      P+  P   +P  +SP +P     +P+   
Sbjct: 4269 PQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPS--- 4325

Query: 605  GALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRA 653
                PS  LP  ++  P   T PG    Q   + PP  G +SP +   A
Sbjct: 4326 ----PSSQLPTEAQLPP---THPGTPKPQGPTLEPP-PGRVSPAAAQLA 4366



 Score = 33.1 bits (74), Expect = 0.88
 Identities = 36/108 (33%), Positives = 40/108 (37%), Gaps = 21/108 (19%)

Query: 535  SPARTPPASLYHGYLPENGVLR------PEPTKQPPYQLRPSLFVLSPIKEPAKVSPRA- 587
            SPA  PP    + Y   N  +R      PE    PP  L PS    SP  EP    P   
Sbjct: 4883 SPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPS--PASPPTEPLVELPTEP 4940

Query: 588  -ASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQP 634
             A P  PS L L       A  P  A P+P    P      G+DS  P
Sbjct: 4941 LAEPPVPSPLPL-------ASSPESARPKPRARPP----EEGEDSRPP 4977



 Score = 29.6 bits (65), Expect = 9.7
 Identities = 32/105 (30%), Positives = 43/105 (40%), Gaps = 20/105 (19%)

Query: 51   QQSSPAPPPAEVHS-----PAADVNQNLASPSATLTTPTSNSSHNP------PATDVNQN 99
            +Q SPAP P   HS        DV Q  A P    + P S  + +P      P  ++   
Sbjct: 4880 KQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTE 4939

Query: 100  PPA-TVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQP 143
            P A   VP  LPL+S    S E+  P     P ++P     D +P
Sbjct: 4940 PLAEPPVPSPLPLAS----SPESARPK----PRARPPEEGEDSRP 4976


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 146/613 (23%), Positives = 203/613 (33%), Gaps = 86/613 (14%)

Query: 55   PAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSI 114
            P  P A  + P A   QN  +P ATL      +   P +      PPA   P +  +  I
Sbjct: 699  PLVPTASENCPVAPSPQNTCAPLATLVL----APEIPKSVPSPSLPPAGTPPGTKKVDGI 754

Query: 115  QQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREA 174
               S+ A + S+   P   P+    D    A A      T L D  S    + S  ++  
Sbjct: 755  SHTSALAPVASS---PKECPTE---DSGASATASSKGTLTYLADSPSPLGVSVSPQTKRP 808

Query: 175  TLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTL--AKP 232
                 S  P  D    +L   + P       +  +S + +  +P   +S    +   A  
Sbjct: 809  PTKKGSAGP--DTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPT 866

Query: 233  PSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAP-QPPSLPDRSPRPQRHIMSR 291
            PS V   + P G+  P   +       L     G   PAP Q P+L   S  P++   + 
Sbjct: 867  PSAVTPLS-PKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATP 925

Query: 292  SPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKS 351
            +P          SP+ +  P      PP+     +T P   W  +PP+ +   P   P +
Sbjct: 926  APKGI-----PASPSPKGAPTPPAATPPSPKGGPAT-PSPKWAPTPPAATPPSPKGGPAT 979

Query: 352  SHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQ 411
               KG   P + T    +      S K   T    P VTP         T          
Sbjct: 980  PSPKGAPTPPAATPPSPKGGPATPSPKGAPT---PPAVTPPSPKGSPAAT---------- 1026

Query: 412  GEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQ 471
                    PF  GA        P+P+   SPAA    +P+ A     P   A   P P  
Sbjct: 1027 --------PFPKGASTPPAATPPSPK--GSPAATP--LPKGA-----PTTPAATLPSPKG 1069

Query: 472  NLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRV 531
              +  S KGA           K        TP     P P  + P S K     P   + 
Sbjct: 1070 GPATPSLKGAPTPPAATPPSPK----GGPATPSPKGAPMPPAATPPSPKGGLATP-PHKG 1124

Query: 532  ASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPA 591
            A  +PA TPP+       P+ G+  P P   P                    +P A  P+
Sbjct: 1125 APTTPAATPPS-------PKGGLATPPPKGAP-------------------TTPAATPPS 1158

Query: 592  KPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPS 651
                L   P  PKGA P +PA   PS        SP      P A  P   G ++  SP 
Sbjct: 1159 PKGGLATPP--PKGA-PTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPK 1215

Query: 652  RAWSPRAKQAPRP 664
             A +  A   P P
Sbjct: 1216 GAPTTPAATPPSP 1228



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 150/641 (23%), Positives = 207/641 (32%), Gaps = 91/641 (14%)

Query: 53   SSPAPPPAEVHSPAADVNQN-----LASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQ 107
            SSP   P E    +A  +       LA   + L    S  +  PP    +  P   +   
Sbjct: 765  SSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNL 824

Query: 108  SLPLSSIQ-----QNSSEAQLPSNGTGPASKPSTLCADGQPQAPAE---EVRCSTLLIDK 159
            S P+S ++     +NS   Q   +       P+     G P   A      +  TL   +
Sbjct: 825  SSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKE 884

Query: 160  VSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPT 219
              TP+     F +E    P+ +   +  M+SS     +            S + A T P 
Sbjct: 885  TPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPA 944

Query: 220  KVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKA----PAPQPP 275
                      A PPS     A P    AP   +    SP         K     PA  PP
Sbjct: 945  ----------ATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPP 994

Query: 276  SLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFT----APPTYTETLSTAPLA 331
            S P   P       + +P        + SPA+   P G  T     PP+   + +  PL 
Sbjct: 995  S-PKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLP 1053

Query: 332  SWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTP 391
                + P+ ++  P   P +  LKG   P + T    +      S K        P  TP
Sbjct: 1054 KGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGA---PMPPAATP 1110

Query: 392  NPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPE 451
             P     + T   K         G    P A           P P+   +  AA    P+
Sbjct: 1111 -PSPKGGLATPPHK---------GAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPK 1160

Query: 452  WASCLKSPR----IQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELAR 507
                   P+      A   P P   L+  S KGA                    T   A 
Sbjct: 1161 GGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAP-------------------TTPAAT 1201

Query: 508  CPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQP--PY 565
             PSP   L +    P  AP        +PA TPP+       P+ G+  P P   P  P 
Sbjct: 1202 PPSPKGGLATP--SPKGAP-------TTPAATPPS-------PKGGLATPSPKGAPTTPA 1245

Query: 566  QLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLP-KGALPPSPALPRPSRSSPGLY 624
               PS     P   P K +P   +   PS    +   P KGA  P+PA+  P     G  
Sbjct: 1246 ATPPSPKG-GPATPPPKGAPTPPAATPPSLKGGLATPPHKGA--PNPAVVTPPSPKGGPA 1302

Query: 625  TSPGQDSLQPTAVSPPY-GGDISPVSPSRAWSPRAKQAPRP 664
            TSP + +  P A +PP   G      P  A +P A   P P
Sbjct: 1303 TSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSP 1343



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 142/641 (22%), Positives = 224/641 (34%), Gaps = 85/641 (13%)

Query: 53   SSPAPPPAEVHSPAADVNQNLASPSATLTTPTS--NSSHNPPATDVNQNPPATVVP--QS 108
            S P P P ++ +  + V     +     T P S   +  +P    +      TV+P  Q+
Sbjct: 506  SPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQA 565

Query: 109  LPLSS--IQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATT 166
             P +S   Q  SS  ++P +     +K S     G+P           L I K ++  T+
Sbjct: 566  APKNSPSFQSTSSSPEIPLSPEATLAKKSL----GEP-----------LPIGKPASSMTS 610

Query: 167  TSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVH 226
                +  A++I +      D  S+  L+     T  V+A    S   A   PT       
Sbjct: 611  PLGVNSSASVIKTDSYAGPD--SAGPLLKSSLITPTVAAFPLESADPAGVAPTT------ 662

Query: 227  FTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDR---SPR 283
               AK  S    TA PF     G  S   ++  ++    G     P  P+  +    +P 
Sbjct: 663  ---AKGTSTYTTTASPF---LEGTVSLAPKNHPVKE---GTLTTLPLVPTASENCPVAPS 713

Query: 284  PQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPT-----YTETLSTAPLASWVRSPP 338
            PQ      + +V    + +  P+    P G  T P T      + T + AP+AS  +  P
Sbjct: 714  PQNTCAPLATLVLAPEIPKSVPSPSLPPAG--TPPGTKKVDGISHTSALAPVASSPKECP 771

Query: 339  SYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDL 398
            +      ++      L   A   S  G+      +R   K      +    TP  +L   
Sbjct: 772  TEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPD----TPIGNLSSP 827

Query: 399  VQTADEK-RRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASC-- 455
            V   +     +      G ++ P       ++    P+P+   +P+A   + P+  +   
Sbjct: 828  VSPVEASFLPENSLSFQGSKDSP-----ATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPP 882

Query: 456  LKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSH----TPELARCPSP 511
             ++P       P P +  +  + K A   +   S  +K     +      +P     P+P
Sbjct: 883  KETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTP 942

Query: 512  TMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSL 571
              + P S K     P   + A   PA TPP+       P+ G   P P   P     P+ 
Sbjct: 943  PAATPPSPKGGPATPSP-KWAPTPPAATPPS-------PKGGPATPSPKGAPT---PPAA 991

Query: 572  FVLSPIKEPAKVSPRAA------SPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYT 625
               SP   PA  SP+ A      +P  P         PKGA  P  A P   + SP    
Sbjct: 992  TPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATP 1051

Query: 626  SPGQDSLQPTAVSP-PYGGDISPVSPSRAWSPRAKQAPRPS 665
             P      P A  P P GG   P +PS   +P    A  PS
Sbjct: 1052 LPKGAPTTPAATLPSPKGG---PATPSLKGAPTPPAATPPS 1089



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 152/638 (23%), Positives = 217/638 (34%), Gaps = 77/638 (12%)

Query: 52   QSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVN--QNPPATVVPQSL 109
            + SPA  P    +P       L SP     TP+   +  PPA      +  PAT  P+  
Sbjct: 1044 KGSPAATPLPKGAPTTPA-ATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGA 1102

Query: 110  PLSSIQQNSSE----AQLPSNG--TGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTP 163
            P+       S     A  P  G  T PA+ P +    G    P  +   +T      S  
Sbjct: 1103 PMPPAATPPSPKGGLATPPHKGAPTTPAATPPS--PKGGLATPPPKGAPTTPAATPPSPK 1160

Query: 164  ATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRA------AATT 217
                +   + A   P++ PP+     ++      P T   +      G A      A TT
Sbjct: 1161 GGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1220

Query: 218  PTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKA----PAPQ 273
            P           A PPS     A P    AP   +    SP         K     PA  
Sbjct: 1221 PA----------ATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAAT 1270

Query: 274  PPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASW 333
            PPSL      P  H  + +P V      +  PA+   P G  T P     +   +P    
Sbjct: 1271 PPSLKGGLATPP-HKGAPNPAVVTPPSPKGGPATSP-PKGAPTPPAATPPSPKGSPGTPP 1328

Query: 334  VRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNP 393
             +  P+   + P S PK +       P+SK G    S ++ G           P  TP+ 
Sbjct: 1329 PKGAPTPPAVTPPS-PKGTPTLPATTPSSKGGPTTPS-SKEGPTP--------PAATPSH 1378

Query: 394  DLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWA 453
                 +     KR        G    P  +          P  R+ A+  +  ++ P   
Sbjct: 1379 KGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAV 1438

Query: 454  SCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRME----KYVIESSSH-----TPE 504
            + +   +  A   PK       + G          S  E    K V  SSS      TP 
Sbjct: 1439 TPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPA 1498

Query: 505  LARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPP 564
                P+    +PSS K     P     +SR     P A+L     P    L P+    PP
Sbjct: 1499 PMGAPTLPAVIPSSPKEVPATP-----SSRRDPIAPTATLLSKKTP--ATLAPKEALIPP 1551

Query: 565  YQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLD------LVPNLPKGALPPSPALPRPSR 618
                 ++ V SP K PA  +P+ A PA PSS +      + P+  KGA  P   L  P+ 
Sbjct: 1552 -----AMTVPSPKKTPAIPTPKEA-PATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAV 1605

Query: 619  SSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSP 656
            +SP    +P      P AV+PP   +  P +P+   +P
Sbjct: 1606 TSPSPKEAP-----TPPAVTPP-SPEKGPATPAPKGTP 1637



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 155/652 (23%), Positives = 214/652 (32%), Gaps = 96/652 (14%)

Query: 31   KENAALLTANGLHLSQNREAQQSSPAP-PPAEVHSPAADVNQNLASPSATLTTPTSNSSH 89
            K+  A     G+  S + +   + PA  PP+    PA    +   +P A  T P+     
Sbjct: 919  KKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAA-TPPSPKGGP 977

Query: 90   NPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEE 149
              P+      PPA   P                       P   P+T    G P  PA  
Sbjct: 978  ATPSPKGAPTPPAATPP----------------------SPKGGPATPSPKGAPTPPA-- 1013

Query: 150  VRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPA-SDFMSSSLLIDIQPNTLVVSADQE 208
                T    K S  AT    F + A+  P++ PP+     +++ L    P T   +    
Sbjct: 1014 ---VTPPSPKGSPAAT---PFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSP 1067

Query: 209  MSGRA-----AATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERR 263
              G A      A TP           A PPS     A P    AP   +    SP     
Sbjct: 1068 KGGPATPSLKGAPTP---------PAATPPSPKGGPATPSPKGAPMPPAATPPSPK---- 1114

Query: 264  HFGEKAPAPQ--PPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTY 321
              G  A  P    P+ P  +P   +  ++  P          +P S   P G    PP  
Sbjct: 1115 --GGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPS---PKGGLATPP-- 1167

Query: 322  TETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMF 381
             +   T P A    +PPS      +  PK +     A P S  G L  + + +G+  +  
Sbjct: 1168 PKGAPTTPAA----TPPSPKGGLATPSPKGAPTTPAATPPSPKGGL-ATPSPKGAPTTPA 1222

Query: 382  TFVEKPK---VTPNPDLLDLVQTA---DEKRRQRDQGEVGVEEEPFALGAEASNFQQEPA 435
                 PK    TP+P        A     K         G    P A           P 
Sbjct: 1223 ATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPP 1282

Query: 436  PRDRASPAAAEEVVPEWASCLKSPRIQAKP----KPKPNQNLSEASGKGAELYARRQSRM 491
             +   +PA      P+       P+    P     P P  +      KGA          
Sbjct: 1283 HKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPS 1342

Query: 492  EKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPE 551
             K      + TP     P    + PSS + PT  P A       PA TPP+       P+
Sbjct: 1343 PKGTPTLPATTPSSKGGP----TTPSSKEGPT-PPAATPSHKGGPAMTPPS-------PK 1390

Query: 552  NGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLV-PNLPKGALPPS 610
             G   P P   P     P++  LSP K PA    R  + A PS  DL  P +   +L  +
Sbjct: 1391 RGPAIPSPKGDP---TSPAVIPLSPKKAPATPVTREGA-ATPSKGDLTPPAVTPVSLKKA 1446

Query: 611  PALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAP 662
            PA   P +  P   +S G  +L   AV+PP   +  P     A S   K+AP
Sbjct: 1447 PATSAP-KGGPATPSSKGDPTL--PAVTPPSPKE-PPAPKQVATSSSPKKAP 1494



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 140/639 (21%), Positives = 207/639 (32%), Gaps = 96/639 (15%)

Query: 41   GLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNP 100
            GL    ++ A   +   PP+    PA    +   +P A  T P+   S   P       P
Sbjct: 1277 GLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAA-TPPSPKGSPGTPPPKGAPTP 1335

Query: 101  PATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKV 160
            PA   P                     T PA+ PS   + G P  P+ +        +  
Sbjct: 1336 PAVTPPSP---------------KGTPTLPATTPS---SKGGPTTPSSK--------EGP 1369

Query: 161  STPATTTSTFSREATLIPSSR-----PPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAA 215
            + PA T S     A   PS +     P      +S  +I + P      A      R  A
Sbjct: 1370 TPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPK----KAPATPVTREGA 1425

Query: 216  TTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPP 275
             TP+K           PP+V      P  ++    TS  +  P           PA  PP
Sbjct: 1426 ATPSK-------GDLTPPAVT-----PVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPP 1473

Query: 276  SLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVR 335
            S P   P P++   S SP        +++PA+   P+G  T P     +    P     R
Sbjct: 1474 S-PKEPPAPKQVATSSSP--------KKAPATP-APMGAPTLPAVIPSSPKEVPATPSSR 1523

Query: 336  SPP-----------------SYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRK 378
              P                     L P +    S  K  A+P  K      S     S  
Sbjct: 1524 RDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPP 1583

Query: 379  SMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEV---GVEEEPFALGAEASNFQQEPA 435
            ++     K   +P   L+    T+   +       V     E+ P     + +       
Sbjct: 1584 AVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVT 1643

Query: 436  PRD-RASPAAAEEVVPEWASCL--KSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRME 492
            P   + SP +   V  +  + +   S  + AK  P   + +  A    +       +R  
Sbjct: 1644 PSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKG 1703

Query: 493  KYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPEN 552
                +SS+ +P +  CP P+    S     T AP       +  ++T        + P+ 
Sbjct: 1704 PQTKKSSATSPPI--CPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGK-DASHSPKG 1760

Query: 553  GVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDL----VPNLP--KGA 606
             +  PE     P        VL P  E A VS   A+P+ P SL L    VP LP  +  
Sbjct: 1761 PLAPPESKASTPLTAAAFEKVL-PKPESASVS---AAPSPPVSLPLAPSPVPTLPPKQQF 1816

Query: 607  LPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDI 645
            LP SP L   S S P       +D L P     P  G +
Sbjct: 1817 LPSSPGLVLESPSKP--LAPADEDELLPLIPPEPISGGV 1853



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 147/657 (22%), Positives = 227/657 (34%), Gaps = 119/657 (18%)

Query: 64  SPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPP----ATVVPQSLPLSSIQQNSS 119
           S A  V   L  P  TL  P S +    P +  NQ  P    +T+    L +    Q+SS
Sbjct: 29  SSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLEVP-FPQSSS 87

Query: 120 EAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPS 179
              LP  GT P +        G P +PA     S ++   +    ++++  +  A L P 
Sbjct: 88  GTALPL-GTAPEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVA-LAPH 145

Query: 180 SRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRT 239
           S   +S F  + L     P ++ V+    +   +A   P    SE    L K PS V   
Sbjct: 146 SVQKSSAFPPNLLT---SPPSVAVAESGSVITLSAPIAP----SEPKTNLNKVPSEV--- 195

Query: 240 ARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRM 299
                +  P GT                    P PP +    P    H ++    ++   
Sbjct: 196 -----VPNPKGT--------------------PSPPCIVSTVPY---HCVTPMASIQ--- 224

Query: 300 MGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAV 359
                            + P  T T + A  +  V+     SVL    +P S  LKG   
Sbjct: 225 -------------SGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVS 271

Query: 360 PASKTGILEESMARRGSRKSMFTFVEKPKVTPN--PDLLDLVQTADEKRRQRDQGEVGV- 416
           P +   +  +S+        + T  +K    PN  PD    + +      Q   G V + 
Sbjct: 272 PPAALSLSTQSL-------PVVTSSQK-TAGPNTPPDFPISLGSHLAPLHQSSFGSVQLL 323

Query: 417 -EEEPFALG---------AEASNFQQEPAPRDRASP-AAAEEVVPEWASCL--------K 457
            +  P AL            +S     P+ R    P  +  EVVP   +          K
Sbjct: 324 GQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDK 383

Query: 458 SPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCP-SPTMSLP 516
            P   +     P+ +L+ A+       +   S + K    ++ H P +A+ P S   + P
Sbjct: 384 GPSTISSITCSPSGSLNVATSFS---LSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTP 440

Query: 517 SSWKYPTNAPGA----FRVAS--RSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPS 570
                P     A    F VA+    P  + P S      P   V+ P   K+P  Q+  +
Sbjct: 441 LVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATT 500

Query: 571 LF--VLSPIKEP--AKVSPRAASPAKPSSLDL--VPNLPKGALPPSPALPRPSRSSPGLY 624
           L   V  P+ +P   K  P +     P+  DL  VP   +GA P SPA         GL 
Sbjct: 501 LRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGA-PFSPA-------QAGLT 552

Query: 625 TSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVWKPS 681
           T      L     +P      SP   S + SP    +P  + + ++ G    + KP+
Sbjct: 553 TKKDPTVLPLVQAAPKN----SPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPA 605


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 118/497 (23%), Positives = 172/497 (34%), Gaps = 95/497 (19%)

Query: 256 RSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERR------------MMGQR 303
           RS    RR    + P+P+  + P R P P RH  SRSP+  RR                R
Sbjct: 307 RSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSR 366

Query: 304 SPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHL-KGQAVPAS 362
           S +  ++P    ++PP  T  LS +      R  PS     P   PK+ H    Q    +
Sbjct: 367 SRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPP---PKTRHSPTPQQSNRT 423

Query: 363 KTGILEESMARRGSRKSMFTFVEK---PKVTPNPDLLDLVQTADEKR---------RQRD 410
           +   +  S  R   + +     EK   P   P P  ++L ++ ++K          +QR 
Sbjct: 424 RKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRR 483

Query: 411 QGEVGVEEEPFALGAEASNFQQEP----------APRDRASPAAAEEVVPEWASCLKSPR 460
           Q     ++     G+ +S+  + P            R R SP+ +    P       SPR
Sbjct: 484 QYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPR 543

Query: 461 IQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSP-TMSLPSSW 519
            + +  P P       S   A    RR++        + S  P   R PSP   S P   
Sbjct: 544 GRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPR-RRSPSPRRYSPPIQR 602

Query: 520 KYPTNAPGAFRVASRSP-------------------------------ARTPPASLYH-- 546
           +Y  + P   R AS  P                                R+P  S  H  
Sbjct: 603 RYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRK 662

Query: 547 GYLPENGVLR---PEPTKQPPYQLRPSLFVLS----PIKEPAKVSPRAASPAKPSSLDL- 598
           G  P         P+P K+     RP     S    P++  A  SP+      PS+  + 
Sbjct: 663 GSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIR 722

Query: 599 ------VPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSR 652
                  P   K A  PSP   R   SS  +  SP   + +P A   P    +   SPS 
Sbjct: 723 RVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSP----VQSQSPST 778

Query: 653 AWSP----RAKQAPRPS 665
            WSP    +  ++P PS
Sbjct: 779 NWSPAVPVKKAKSPTPS 795



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 103/407 (25%), Positives = 136/407 (33%), Gaps = 48/407 (11%)

Query: 282 PRPQRHIMSRSPMVERRMMGQRSPASERR-PLGNFTAPPTYTETLSTAPLASWVRSPPSY 340
           PR +    SRS    RR   +R P+  RR P      PP +    S +P+    RS  S 
Sbjct: 298 PRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRR--SRSPVRRRRRSSASL 355

Query: 341 SVLYPSS------DPKSSHLKGQAVPASKTGILEESMA--RRGSRKSMFTFVEKPKVTPN 392
           S    SS       P     K  + P  KT  L  S +  RR  R S       P  TP 
Sbjct: 356 SGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPS-------PPATPP 408

Query: 393 PDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQE---PAPRDRASPAAAEEVV 449
           P            R ++ +  V        +       ++E   PAP+ R    +  E  
Sbjct: 409 PKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEED 468

Query: 450 PEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSR---MEKYVIESSSHTPELA 506
                       Q +   + NQ  S  SG  +     R  R       V     H+P  +
Sbjct: 469 KGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRS 528

Query: 507 RCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQ 566
             PSP        +    +P   R  S SP   PP        P     R      PP +
Sbjct: 529 ASPSPRK------RQKETSPRGRRRRSPSP---PPTRRRRSPSPAPPPRRRRTPTPPPRR 579

Query: 567 LRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTS 626
             P     SP       SPR  SP  P      P+ P      SP  P   R+SP    S
Sbjct: 580 RTP-----SPPPRRRSPSPRRYSP--PIQRRYSPSPPPKRRTASPPPPPKRRASP----S 628

Query: 627 PGQDSLQPTAVSPPYGGDISPVSPSR--AWSPRAKQAPRPSFSTRNA 671
           P     +  + SPP     SPV+  R  + S + ++   PS STR A
Sbjct: 629 P--PPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREA 673



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 140/614 (22%), Positives = 209/614 (34%), Gaps = 117/614 (19%)

Query: 55  PAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQ---------------- 98
           P P      SP     ++ AS S + ++ +S+ S +PP     +                
Sbjct: 334 PPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSAS 393

Query: 99  --------NPPATVVPQSLPLSSIQQN-----SSEAQLPSNGTGPASK-PSTLCADGQPQ 144
                   +PPAT  P++    + QQ+     S  +  P   +G  +K   T   +    
Sbjct: 394 PPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSP 453

Query: 145 AP-AEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVV 203
           AP   +V  S    DK    A   S   R       ++  +SD  SSS   D +P    V
Sbjct: 454 APKPRKVELSESEEDKGGKMAAADSVQQRR-QYRRQNQQSSSDSGSSSSSEDERPKRSHV 512

Query: 204 SADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERR 263
              +   GR    +P++  S         PS   R        +P G  +   SP   RR
Sbjct: 513 KNGE--VGRRRRHSPSRSAS---------PSPRKRQKE----TSPRGRRRRSPSPPPTRR 557

Query: 264 HFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQR--SPASERR-----PLGNFT 316
               ++P+P PP    R+P P     + SP   RR    R  SP  +RR     P    T
Sbjct: 558 ---RRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRT 614

Query: 317 A----PPTYTETLSTAPLASWVRSPPSYSVLYP-----SSDPKSSHLKGQAVPASKTGIL 367
           A    PP    + S  P      SPP      P     S    S H KG + P+  T   
Sbjct: 615 ASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSS-PSRST--R 671

Query: 368 EESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQ------RDQGEVGVEEEPF 421
           E    +   R S       P+ + +P  +    ++  +RRQ      R    V    EP 
Sbjct: 672 EARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPK 731

Query: 422 ALGAEASNFQQ-------------EPAPRDRASPAAAEEVVPEWASCLKSPRIQAK---- 464
            +   AS   Q              P P  +  PA    V  +  S   SP +  K    
Sbjct: 732 KIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKS 791

Query: 465 --PKPKPNQNL-SEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKY 521
             P P P +N   E  GK  +    ++ + +K   +   H  E A   +   ++      
Sbjct: 792 PTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAV------ 845

Query: 522 PTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSP-IKEP 580
               P A   A+ + A+  P            V  PEP K+   +   +L  L   ++E 
Sbjct: 846 ---TPAAIAAATTTLAQEEP------------VAAPEPKKETESEAEDNLDDLEKHLREK 890

Query: 581 AKVSPRAASPAKPS 594
           A  S R A  +  S
Sbjct: 891 ALRSMRKAQVSPQS 904



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 145/657 (22%), Positives = 215/657 (32%), Gaps = 120/657 (18%)

Query: 49  EAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQS 108
           +++  SPAP   E      + +  +  PS    T TS+    P    + +  P    P+ 
Sbjct: 206 KSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPE--PKEPSPEK 263

Query: 109 LPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS 168
              +S ++   E   P + +   S+  T         P    R  +        P+    
Sbjct: 264 ---NSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRR 320

Query: 169 TFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFT 228
              R  T      PP     S S +   + ++  +S     S  + + +P K        
Sbjct: 321 PSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPK-------- 372

Query: 229 LAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSL-----PDRSPR 283
             KPP    RT+ P     P  T ++  S    RR      PA  PP       P +S R
Sbjct: 373 --KPPK---RTSSP-----PRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNR 422

Query: 284 PQRHIMSRSPM-----------VERRMMGQRSPA--------SERRPLGNFTAPPTYTET 324
            ++  +S SP             E+R     +P         SE    G   A  +  + 
Sbjct: 423 TRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQR 482

Query: 325 LSTAPLASWVRSPPSYSVLYPSSDPKSSHLKG------------QAVPASKTGILEESMA 372
                      S    S       PK SH+K             ++   S     +E+  
Sbjct: 483 RQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSP 542

Query: 373 RRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQ 432
           R   R+S      + + +P+P        A   RR+R          P          ++
Sbjct: 543 RGRRRRSPSPPPTRRRRSPSP--------APPPRRRRTPTPPPRRRTP-----SPPPRRR 589

Query: 433 EPAPRDRASPAAAEEVVPE------WASCLKSPRIQAKPKPKPNQNLSEA---SGKGAEL 483
            P+PR R SP       P        AS    P+ +A P P P + +S +     + + +
Sbjct: 590 SPSPR-RYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPV 648

Query: 484 YARRQ----------SRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVAS 533
             RR           S   +   E+ S  P     PSP    P +   P   P   R AS
Sbjct: 649 TKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSP---PPVRRGAS 705

Query: 534 RSPARTPPASLYHGYLPENGVLR-PEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAK 592
            SP R    S      P   V R PEP K               IK+ A  SP+  S  +
Sbjct: 706 SSPQRRQSPS--PSTRPIRRVSRTPEPKK---------------IKKAASPSPQ--SVRR 746

Query: 593 PSSLDLVPNLPKGALPPSPALPRPSRS-SPGLYTSPG---QDSLQPT-AVSPPYGGD 644
            SS   V   P+ A    PA P P +S SP    SP    + +  PT + SPP   D
Sbjct: 747 VSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSD 803



 Score = 37.0 bits (84), Expect = 0.061
 Identities = 56/258 (21%), Positives = 89/258 (34%), Gaps = 49/258 (18%)

Query: 48  REAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNS---------SHNPPATDVNQ 98
           R  +  SPAPPP    +P     +   SP     +P+            S +PP      
Sbjct: 556 RRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTA 615

Query: 99  NPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASK---PSTLCADGQPQAPAEEVRCSTL 155
           +PP     ++ P    ++  S +  P   + P +K   PS      +  +P+   R    
Sbjct: 616 SPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTR---- 671

Query: 156 LIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAA 215
                   A +     R +   PS RP A             P T   S+      R A+
Sbjct: 672 -------EARSPQPNKRHS---PSPRPRA-------------PQT---SSSPPPVRRGAS 705

Query: 216 TTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPP 275
           ++P +  S    T  +P   V+RT  P  I+          SP   RR    ++ +  P 
Sbjct: 706 SSPQRRQSPSPST--RPIRRVSRTPEPKKIKKAASP-----SPQSVRRVSSSRSVSGSPE 758

Query: 276 SLPDRSPRPQRHIMSRSP 293
               + P P   + S+SP
Sbjct: 759 PAAKKPPAPPSPVQSQSP 776


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 132/666 (19%), Positives = 210/666 (31%), Gaps = 71/666 (10%)

Query: 46  QNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTP-TSNSSHNPPATDVNQNPPATV 104
           +NR  ++ +P PP  +      +    L +    +TTP TS + HN  +T         +
Sbjct: 71  KNRTKKKPTPKPPVVD------EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPI 124

Query: 105 VPQ-SLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCS---TLLIDKV 160
            P+ SLP +S    S E  L  N         T   + Q     +E   S   T  I+K 
Sbjct: 125 NPRPSLPPNS--DTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT 182

Query: 161 S--------------TPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTL--VVS 204
           S              TP   T+T     T      P      +S+   +  P T+    +
Sbjct: 183 SAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT 242

Query: 205 ADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPG-GTSQMERSPMLERR 263
             +E +     + PT        T  +P     +   P   + P   T++   +   E  
Sbjct: 243 TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 302

Query: 264 HFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTE 323
               K PAP  P  P  +P   +     +P        + +P + + P       P  T 
Sbjct: 303 PTTPKKPAPTTPKEP--APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTT 360

Query: 324 TLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPAS---KTGILEESMARRGSRKSM 380
               AP      +P +     P++  + +    ++ P +         +S        S 
Sbjct: 361 PKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 420

Query: 381 FTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPR--D 438
            T  E    TP        +       +        E  P      A    +EPAP    
Sbjct: 421 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK 480

Query: 439 RASPAAAEEVVPEWASCLKSPRIQAKPKP------------KPNQNLSEASGKGAELYAR 486
             +P   +++ P     L +P    KP P            +P     E         A 
Sbjct: 481 ETAPTTPKKLTPTTPEKL-APTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA 539

Query: 487 RQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYH 546
             +  E          P   + P+PT    ++   PT   G      + PA T P     
Sbjct: 540 PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA---PTTPKGTAPTTLKEPAPTTPKK--- 593

Query: 547 GYLPENGVLRPEPTKQP-------PYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLV 599
              P    L P  TK+P       P    P     +  KEPA  +P+  +P  P      
Sbjct: 594 ---PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG--TA 648

Query: 600 PNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAK 659
           P   K   P +P  P P   +P   T+ G  S      +P    + +P +P    +P   
Sbjct: 649 PTTLKEPAPTTPKKPAPKELAP--TTTKGPTSTTSDKPAPTTPKETAPTTPKEP-APTTP 705

Query: 660 QAPRPS 665
           + P P+
Sbjct: 706 KKPAPT 711



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 129/666 (19%), Positives = 201/666 (30%), Gaps = 78/666 (11%)

Query: 5   SEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHS 64
           S+E SL  + E     +E          +    T +        +      AP    +  
Sbjct: 137 SKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 196

Query: 65  PAADVNQNLASPSATLTT-PTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQL 123
           P          P+ T    PT  +   P +T   +  P T+  +S P +   +  +    
Sbjct: 197 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI--KSAPTTP--KEPAPTTT 252

Query: 124 PSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS--TFSREATLIPSSR 181
            S  T P     T   +  P  P E    +T    K   P TT S  T  +E       +
Sbjct: 253 KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT----KEPAPTTTKSAPTTPKEPAPTTPKK 308

Query: 182 PPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTAR 241
           P  +     +     +P           +   A TTP +          KP     +   
Sbjct: 309 PAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP---KKPAPTTPKEPA 365

Query: 242 PFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPP-SLPDRSPRPQRHIMSRSPMVERRMM 300
           P   + P  T+  E SP         K PAP    S P  +  P       +P   +   
Sbjct: 366 PTTPKEPAPTTTKEPSPTTP------KEPAPTTTKSAPTTTKEPAPTTTKSAPTTPK--- 416

Query: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSD----PKSSHLKG 356
            + SP + + P       P  T     AP      +P +     P++     P +     
Sbjct: 417 -EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 475

Query: 357 QAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGV 416
              P        + +      K   T  EKP  T   +L     T +E      +     
Sbjct: 476 PTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT--TPEEPTPTTPE----- 528

Query: 417 EEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEA 476
           E  P    A A N  +EPAP     PA               P    +P P   +  +  
Sbjct: 529 EPAPTTPKAAAPNTPKEPAPTTPKEPA---------------PTTPKEPAPTTPKETAPT 573

Query: 477 SGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSP 536
           + KG      ++              P   + P+P    P++ K PT+           P
Sbjct: 574 TPKGTAPTTLKEP------------APTTPKKPAPKELAPTTTKEPTST------TCDKP 615

Query: 537 ARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSL 596
           A T P     G  P         T + P    P     + +KEPA  +P+     KP+  
Sbjct: 616 APTTPK----GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK-----KPAPK 666

Query: 597 DLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSP 656
           +L P   KG    +   P P+       T+P + +        P   +  P + S   +P
Sbjct: 667 ELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTP 726

Query: 657 RAKQAP 662
              + P
Sbjct: 727 TTTKEP 732



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 124/618 (20%), Positives = 188/618 (30%), Gaps = 77/618 (12%)

Query: 38  TANGLHLSQNREAQQSSPAPP-------PAEVHSPAADVNQNLASPSATLTTPTSNSSHN 90
           T  G  L+  +E   ++P  P       P      +A       +P+ T + PT+     
Sbjct: 204 TTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA 263

Query: 91  PPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEV 150
           P  T      PA   P+  P  +  +  +     S  T P     T      P  P E  
Sbjct: 264 PTTT----KEPAPTTPKE-PAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 318

Query: 151 RCS----TLLIDKVSTPATT--TSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVS 204
             +    T    K   P T     T  +E       +P  +     +     +P      
Sbjct: 319 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 378

Query: 205 ADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRH 264
                + +  A T TK       T  K P+     + P   + P  T+  E +P      
Sbjct: 379 EPSPTTPKEPAPTTTKSAP----TTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTP--- 431

Query: 265 FGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTET 324
              K PAP  P  P  +P   +     +P        + +P + ++P       P  T  
Sbjct: 432 ---KEPAPTTPKKP--APTTPKEPAPTTPK-------EPAPTTTKKPAPTTPKEPAPTTP 479

Query: 325 LSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFV 384
             TAP      +P +   L P++  K         PA  T    E +A     +   T  
Sbjct: 480 KETAPTTPKKLTPTTPEKLAPTTPEK---------PAPTT---PEELAPTTPEEPTPTTP 527

Query: 385 EKPKVT------PNPDLLDLVQTADEKRRQRDQGEVGV---EEEPFALGAEASNFQQEPA 435
           E+P  T      PN        T  E      +        E  P      A    +EPA
Sbjct: 528 EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA 587

Query: 436 PRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYV 495
           P     PA  +E+ P   +  K P      KP P      A     E      +  E   
Sbjct: 588 PTTPKKPAP-KELAP---TTTKEPTSTTCDKPAPTTPKGTAPTTPKE--PAPTTPKEPAP 641

Query: 496 IESSSHTPELARCPSPTMSLPSSWKY--PTNAPGAFRVASRSPARTPPASLYHGYLPENG 553
                  P   + P+PT     + K   PT   G     S  PA T P         E  
Sbjct: 642 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA 701

Query: 554 VLRPEP----TKQPPYQLRPSLFVLSPIKEPAKV-------SPRAASPAKPSSLDLVPNL 602
              P+     T + P      +   +  KEP  +       +P  ++   P +L+  P  
Sbjct: 702 PTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE 761

Query: 603 PKGALPPSPALPRPSRSS 620
           P      +PA  +P  ++
Sbjct: 762 PGVPTTKTPAATKPEMTT 779



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 108/569 (18%), Positives = 183/569 (32%), Gaps = 116/569 (20%)

Query: 50  AQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
           A  ++  P P     PA    +  A  +    TPT+     P   +     PA   P+ L
Sbjct: 459 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE----KPAPTTPEEL 514

Query: 110 -PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS 168
            P +  +   +  + P+  T  A+ P+T      P+ PA             +TP     
Sbjct: 515 APTTPEEPTPTTPEEPAPTTPKAAAPNT------PKEPAP------------TTPKEPAP 556

Query: 169 TFSREA--TLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVH 226
           T  +E   T    + P      + + L +  P T    A +E++       PT       
Sbjct: 557 TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-------PTTTKEPTS 609

Query: 227 FTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGE--KAPAPQPPSLPDRSPRP 284
            T  KP     +   P   + P  T+  E +P   +       K PAP  P    + P P
Sbjct: 610 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP----KKPAP 665

Query: 285 QRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLY 344
           +        +      G  S  S++       AP T  ET  T P      +P   +   
Sbjct: 666 KE-------LAPTTTKGPTSTTSDK------PAPTTPKETAPTTPKEPAPTTPKKPAPTT 712

Query: 345 PSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADE 404
           P + P ++                             + V  P  T  P       T   
Sbjct: 713 PETPPPTT-----------------------------SEVSTPTTTKEP-------TTIH 736

Query: 405 KRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAK 464
           K       E+  E  P AL     N  +EP      +PAA +   PE  +  K    +  
Sbjct: 737 KSPDESTPELSAEPTPKAL----ENSPKEPGVPTTKTPAATK---PEMTTTAKDKTTERD 789

Query: 465 PKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTN 524
            +  P    +               +M K    ++  T E ++  + T  + S+    T 
Sbjct: 790 LRTTPETTTAAP-------------KMTKETATTTEKTTE-SKITATTTQVTSTTTQDTT 835

Query: 525 APGAFRVAS-RSPARTPPASLYHGYLPENGVL-RPEPTKQPPYQLRPSLFVLSPIKEPAK 582
               F++ + ++    P  +     +    ++ +PE T +P  +   S       ++P K
Sbjct: 836 P---FKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK 892

Query: 583 VSPRAASPAKPSSLDLVPNLPKGALPPSP 611
              +  S  KP ++   P + K    P+P
Sbjct: 893 APKKPTSTKKPKTM---PRVRKPKTTPTP 918


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 132/666 (19%), Positives = 210/666 (31%), Gaps = 71/666 (10%)

Query: 46  QNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTP-TSNSSHNPPATDVNQNPPATV 104
           +NR  ++ +P PP  +      +    L +    +TTP TS + HN  +T         +
Sbjct: 112 KNRTKKKPTPKPPVVD------EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPI 165

Query: 105 VPQ-SLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCS---TLLIDKV 160
            P+ SLP +S    S E  L  N         T   + Q     +E   S   T  I+K 
Sbjct: 166 NPRPSLPPNS--DTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT 223

Query: 161 S--------------TPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTL--VVS 204
           S              TP   T+T     T      P      +S+   +  P T+    +
Sbjct: 224 SAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT 283

Query: 205 ADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPG-GTSQMERSPMLERR 263
             +E +     + PT        T  +P     +   P   + P   T++   +   E  
Sbjct: 284 TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 343

Query: 264 HFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTE 323
               K PAP  P  P  +P   +     +P        + +P + + P       P  T 
Sbjct: 344 PTTPKKPAPTTPKEP--APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTT 401

Query: 324 TLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPAS---KTGILEESMARRGSRKSM 380
               AP      +P +     P++  + +    ++ P +         +S        S 
Sbjct: 402 PKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 461

Query: 381 FTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPR--D 438
            T  E    TP        +       +        E  P      A    +EPAP    
Sbjct: 462 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK 521

Query: 439 RASPAAAEEVVPEWASCLKSPRIQAKPKP------------KPNQNLSEASGKGAELYAR 486
             +P   +++ P     L +P    KP P            +P     E         A 
Sbjct: 522 ETAPTTPKKLTPTTPEKL-APTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA 580

Query: 487 RQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYH 546
             +  E          P   + P+PT    ++   PT   G      + PA T P     
Sbjct: 581 PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA---PTTPKGTAPTTLKEPAPTTPKK--- 634

Query: 547 GYLPENGVLRPEPTKQP-------PYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLV 599
              P    L P  TK+P       P    P     +  KEPA  +P+  +P  P      
Sbjct: 635 ---PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG--TA 689

Query: 600 PNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAK 659
           P   K   P +P  P P   +P   T+ G  S      +P    + +P +P    +P   
Sbjct: 690 PTTLKEPAPTTPKKPAPKELAP--TTTKGPTSTTSDKPAPTTPKETAPTTPKEP-APTTP 746

Query: 660 QAPRPS 665
           + P P+
Sbjct: 747 KKPAPT 752



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 129/666 (19%), Positives = 201/666 (30%), Gaps = 78/666 (11%)

Query: 5   SEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHS 64
           S+E SL  + E     +E          +    T +        +      AP    +  
Sbjct: 178 SKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 237

Query: 65  PAADVNQNLASPSATLTT-PTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQL 123
           P          P+ T    PT  +   P +T   +  P T+  +S P +   +  +    
Sbjct: 238 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI--KSAPTTP--KEPAPTTT 293

Query: 124 PSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS--TFSREATLIPSSR 181
            S  T P     T   +  P  P E    +T    K   P TT S  T  +E       +
Sbjct: 294 KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT----KEPAPTTTKSAPTTPKEPAPTTPKK 349

Query: 182 PPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTAR 241
           P  +     +     +P           +   A TTP +          KP     +   
Sbjct: 350 PAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP---KKPAPTTPKEPA 406

Query: 242 PFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPP-SLPDRSPRPQRHIMSRSPMVERRMM 300
           P   + P  T+  E SP         K PAP    S P  +  P       +P   +   
Sbjct: 407 PTTPKEPAPTTTKEPSPTTP------KEPAPTTTKSAPTTTKEPAPTTTKSAPTTPK--- 457

Query: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSD----PKSSHLKG 356
            + SP + + P       P  T     AP      +P +     P++     P +     
Sbjct: 458 -EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 516

Query: 357 QAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGV 416
              P        + +      K   T  EKP  T   +L     T +E      +     
Sbjct: 517 PTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT--TPEEPTPTTPE----- 569

Query: 417 EEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEA 476
           E  P    A A N  +EPAP     PA               P    +P P   +  +  
Sbjct: 570 EPAPTTPKAAAPNTPKEPAPTTPKEPA---------------PTTPKEPAPTTPKETAPT 614

Query: 477 SGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSP 536
           + KG      ++              P   + P+P    P++ K PT+           P
Sbjct: 615 TPKGTAPTTLKEP------------APTTPKKPAPKELAPTTTKEPTST------TCDKP 656

Query: 537 ARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSL 596
           A T P     G  P         T + P    P     + +KEPA  +P+     KP+  
Sbjct: 657 APTTPK----GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK-----KPAPK 707

Query: 597 DLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSP 656
           +L P   KG    +   P P+       T+P + +        P   +  P + S   +P
Sbjct: 708 ELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTP 767

Query: 657 RAKQAP 662
              + P
Sbjct: 768 TTTKEP 773



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 124/618 (20%), Positives = 188/618 (30%), Gaps = 77/618 (12%)

Query: 38  TANGLHLSQNREAQQSSPAPP-------PAEVHSPAADVNQNLASPSATLTTPTSNSSHN 90
           T  G  L+  +E   ++P  P       P      +A       +P+ T + PT+     
Sbjct: 245 TTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA 304

Query: 91  PPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEV 150
           P  T      PA   P+  P  +  +  +     S  T P     T      P  P E  
Sbjct: 305 PTTT----KEPAPTTPKE-PAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 359

Query: 151 RCS----TLLIDKVSTPATT--TSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVS 204
             +    T    K   P T     T  +E       +P  +     +     +P      
Sbjct: 360 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 419

Query: 205 ADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRH 264
                + +  A T TK       T  K P+     + P   + P  T+  E +P      
Sbjct: 420 EPSPTTPKEPAPTTTKSAP----TTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTP--- 472

Query: 265 FGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTET 324
              K PAP  P  P  +P   +     +P        + +P + ++P       P  T  
Sbjct: 473 ---KEPAPTTPKKP--APTTPKEPAPTTPK-------EPAPTTTKKPAPTTPKEPAPTTP 520

Query: 325 LSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFV 384
             TAP      +P +   L P++  K         PA  T    E +A     +   T  
Sbjct: 521 KETAPTTPKKLTPTTPEKLAPTTPEK---------PAPTT---PEELAPTTPEEPTPTTP 568

Query: 385 EKPKVT------PNPDLLDLVQTADEKRRQRDQGEVGV---EEEPFALGAEASNFQQEPA 435
           E+P  T      PN        T  E      +        E  P      A    +EPA
Sbjct: 569 EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA 628

Query: 436 PRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYV 495
           P     PA  +E+ P   +  K P      KP P      A     E      +  E   
Sbjct: 629 PTTPKKPAP-KELAP---TTTKEPTSTTCDKPAPTTPKGTAPTTPKE--PAPTTPKEPAP 682

Query: 496 IESSSHTPELARCPSPTMSLPSSWKY--PTNAPGAFRVASRSPARTPPASLYHGYLPENG 553
                  P   + P+PT     + K   PT   G     S  PA T P         E  
Sbjct: 683 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA 742

Query: 554 VLRPEP----TKQPPYQLRPSLFVLSPIKEPAKV-------SPRAASPAKPSSLDLVPNL 602
              P+     T + P      +   +  KEP  +       +P  ++   P +L+  P  
Sbjct: 743 PTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE 802

Query: 603 PKGALPPSPALPRPSRSS 620
           P      +PA  +P  ++
Sbjct: 803 PGVPTTKTPAATKPEMTT 820



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 108/569 (18%), Positives = 183/569 (32%), Gaps = 116/569 (20%)

Query: 50  AQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
           A  ++  P P     PA    +  A  +    TPT+     P   +     PA   P+ L
Sbjct: 500 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE----KPAPTTPEEL 555

Query: 110 -PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS 168
            P +  +   +  + P+  T  A+ P+T      P+ PA             +TP     
Sbjct: 556 APTTPEEPTPTTPEEPAPTTPKAAAPNT------PKEPAP------------TTPKEPAP 597

Query: 169 TFSREA--TLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVH 226
           T  +E   T    + P      + + L +  P T    A +E++       PT       
Sbjct: 598 TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-------PTTTKEPTS 650

Query: 227 FTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGE--KAPAPQPPSLPDRSPRP 284
            T  KP     +   P   + P  T+  E +P   +       K PAP  P    + P P
Sbjct: 651 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP----KKPAP 706

Query: 285 QRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLY 344
           +        +      G  S  S++       AP T  ET  T P      +P   +   
Sbjct: 707 KE-------LAPTTTKGPTSTTSDK------PAPTTPKETAPTTPKEPAPTTPKKPAPTT 753

Query: 345 PSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADE 404
           P + P ++                             + V  P  T  P       T   
Sbjct: 754 PETPPPTT-----------------------------SEVSTPTTTKEP-------TTIH 777

Query: 405 KRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAK 464
           K       E+  E  P AL     N  +EP      +PAA +   PE  +  K    +  
Sbjct: 778 KSPDESTPELSAEPTPKAL----ENSPKEPGVPTTKTPAATK---PEMTTTAKDKTTERD 830

Query: 465 PKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTN 524
            +  P    +               +M K    ++  T E ++  + T  + S+    T 
Sbjct: 831 LRTTPETTTAAP-------------KMTKETATTTEKTTE-SKITATTTQVTSTTTQDTT 876

Query: 525 APGAFRVAS-RSPARTPPASLYHGYLPENGVL-RPEPTKQPPYQLRPSLFVLSPIKEPAK 582
               F++ + ++    P  +     +    ++ +PE T +P  +   S       ++P K
Sbjct: 877 P---FKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK 933

Query: 583 VSPRAASPAKPSSLDLVPNLPKGALPPSP 611
              +  S  KP ++   P + K    P+P
Sbjct: 934 APKKPTSTKKPKTM---PRVRKPKTTPTP 959


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 132/666 (19%), Positives = 210/666 (31%), Gaps = 71/666 (10%)

Query: 46  QNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTP-TSNSSHNPPATDVNQNPPATV 104
           +NR  ++ +P PP  +      +    L +    +TTP TS + HN  +T         +
Sbjct: 164 KNRTKKKPTPKPPVVD------EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPI 217

Query: 105 VPQ-SLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCS---TLLIDKV 160
            P+ SLP +S    S E  L  N         T   + Q     +E   S   T  I+K 
Sbjct: 218 NPRPSLPPNS--DTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT 275

Query: 161 S--------------TPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTL--VVS 204
           S              TP   T+T     T      P      +S+   +  P T+    +
Sbjct: 276 SAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT 335

Query: 205 ADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPG-GTSQMERSPMLERR 263
             +E +     + PT        T  +P     +   P   + P   T++   +   E  
Sbjct: 336 TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 395

Query: 264 HFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTE 323
               K PAP  P  P  +P   +     +P        + +P + + P       P  T 
Sbjct: 396 PTTPKKPAPTTPKEP--APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTT 453

Query: 324 TLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPAS---KTGILEESMARRGSRKSM 380
               AP      +P +     P++  + +    ++ P +         +S        S 
Sbjct: 454 PKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 513

Query: 381 FTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPR--D 438
            T  E    TP        +       +        E  P      A    +EPAP    
Sbjct: 514 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK 573

Query: 439 RASPAAAEEVVPEWASCLKSPRIQAKPKP------------KPNQNLSEASGKGAELYAR 486
             +P   +++ P     L +P    KP P            +P     E         A 
Sbjct: 574 ETAPTTPKKLTPTTPEKL-APTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA 632

Query: 487 RQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYH 546
             +  E          P   + P+PT    ++   PT   G      + PA T P     
Sbjct: 633 PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA---PTTPKGTAPTTLKEPAPTTPKK--- 686

Query: 547 GYLPENGVLRPEPTKQP-------PYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLV 599
              P    L P  TK+P       P    P     +  KEPA  +P+  +P  P      
Sbjct: 687 ---PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG--TA 741

Query: 600 PNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAK 659
           P   K   P +P  P P   +P   T+ G  S      +P    + +P +P    +P   
Sbjct: 742 PTTLKEPAPTTPKKPAPKELAP--TTTKGPTSTTSDKPAPTTPKETAPTTPKEP-APTTP 798

Query: 660 QAPRPS 665
           + P P+
Sbjct: 799 KKPAPT 804



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 129/666 (19%), Positives = 201/666 (30%), Gaps = 78/666 (11%)

Query: 5   SEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHS 64
           S+E SL  + E     +E          +    T +        +      AP    +  
Sbjct: 230 SKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 289

Query: 65  PAADVNQNLASPSATLTT-PTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQL 123
           P          P+ T    PT  +   P +T   +  P T+  +S P +   +  +    
Sbjct: 290 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI--KSAPTTP--KEPAPTTT 345

Query: 124 PSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS--TFSREATLIPSSR 181
            S  T P     T   +  P  P E    +T    K   P TT S  T  +E       +
Sbjct: 346 KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT----KEPAPTTTKSAPTTPKEPAPTTPKK 401

Query: 182 PPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTAR 241
           P  +     +     +P           +   A TTP +          KP     +   
Sbjct: 402 PAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP---KKPAPTTPKEPA 458

Query: 242 PFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPP-SLPDRSPRPQRHIMSRSPMVERRMM 300
           P   + P  T+  E SP         K PAP    S P  +  P       +P   +   
Sbjct: 459 PTTPKEPAPTTTKEPSPTTP------KEPAPTTTKSAPTTTKEPAPTTTKSAPTTPK--- 509

Query: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSD----PKSSHLKG 356
            + SP + + P       P  T     AP      +P +     P++     P +     
Sbjct: 510 -EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 568

Query: 357 QAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGV 416
              P        + +      K   T  EKP  T   +L     T +E      +     
Sbjct: 569 PTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT--TPEEPTPTTPE----- 621

Query: 417 EEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEA 476
           E  P    A A N  +EPAP     PA               P    +P P   +  +  
Sbjct: 622 EPAPTTPKAAAPNTPKEPAPTTPKEPA---------------PTTPKEPAPTTPKETAPT 666

Query: 477 SGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSP 536
           + KG      ++              P   + P+P    P++ K PT+           P
Sbjct: 667 TPKGTAPTTLKEP------------APTTPKKPAPKELAPTTTKEPTST------TCDKP 708

Query: 537 ARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSL 596
           A T P     G  P         T + P    P     + +KEPA  +P+     KP+  
Sbjct: 709 APTTPK----GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK-----KPAPK 759

Query: 597 DLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSP 656
           +L P   KG    +   P P+       T+P + +        P   +  P + S   +P
Sbjct: 760 ELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTP 819

Query: 657 RAKQAP 662
              + P
Sbjct: 820 TTTKEP 825



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 124/618 (20%), Positives = 188/618 (30%), Gaps = 77/618 (12%)

Query: 38  TANGLHLSQNREAQQSSPAPP-------PAEVHSPAADVNQNLASPSATLTTPTSNSSHN 90
           T  G  L+  +E   ++P  P       P      +A       +P+ T + PT+     
Sbjct: 297 TTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA 356

Query: 91  PPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEV 150
           P  T      PA   P+  P  +  +  +     S  T P     T      P  P E  
Sbjct: 357 PTTT----KEPAPTTPKE-PAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 411

Query: 151 RCS----TLLIDKVSTPATT--TSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVS 204
             +    T    K   P T     T  +E       +P  +     +     +P      
Sbjct: 412 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 471

Query: 205 ADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRH 264
                + +  A T TK       T  K P+     + P   + P  T+  E +P      
Sbjct: 472 EPSPTTPKEPAPTTTKSAP----TTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTP--- 524

Query: 265 FGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTET 324
              K PAP  P  P  +P   +     +P        + +P + ++P       P  T  
Sbjct: 525 ---KEPAPTTPKKP--APTTPKEPAPTTPK-------EPAPTTTKKPAPTTPKEPAPTTP 572

Query: 325 LSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFV 384
             TAP      +P +   L P++  K         PA  T    E +A     +   T  
Sbjct: 573 KETAPTTPKKLTPTTPEKLAPTTPEK---------PAPTT---PEELAPTTPEEPTPTTP 620

Query: 385 EKPKVT------PNPDLLDLVQTADEKRRQRDQGEVGV---EEEPFALGAEASNFQQEPA 435
           E+P  T      PN        T  E      +        E  P      A    +EPA
Sbjct: 621 EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA 680

Query: 436 PRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYV 495
           P     PA  +E+ P   +  K P      KP P      A     E      +  E   
Sbjct: 681 PTTPKKPAP-KELAP---TTTKEPTSTTCDKPAPTTPKGTAPTTPKE--PAPTTPKEPAP 734

Query: 496 IESSSHTPELARCPSPTMSLPSSWKY--PTNAPGAFRVASRSPARTPPASLYHGYLPENG 553
                  P   + P+PT     + K   PT   G     S  PA T P         E  
Sbjct: 735 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA 794

Query: 554 VLRPEP----TKQPPYQLRPSLFVLSPIKEPAKV-------SPRAASPAKPSSLDLVPNL 602
              P+     T + P      +   +  KEP  +       +P  ++   P +L+  P  
Sbjct: 795 PTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE 854

Query: 603 PKGALPPSPALPRPSRSS 620
           P      +PA  +P  ++
Sbjct: 855 PGVPTTKTPAATKPEMTT 872



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 108/569 (18%), Positives = 183/569 (32%), Gaps = 116/569 (20%)

Query: 50   AQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
            A  ++  P P     PA    +  A  +    TPT+     P   +     PA   P+ L
Sbjct: 552  APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE----KPAPTTPEEL 607

Query: 110  -PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS 168
             P +  +   +  + P+  T  A+ P+T      P+ PA             +TP     
Sbjct: 608  APTTPEEPTPTTPEEPAPTTPKAAAPNT------PKEPAP------------TTPKEPAP 649

Query: 169  TFSREA--TLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVH 226
            T  +E   T    + P      + + L +  P T    A +E++       PT       
Sbjct: 650  TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-------PTTTKEPTS 702

Query: 227  FTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGE--KAPAPQPPSLPDRSPRP 284
             T  KP     +   P   + P  T+  E +P   +       K PAP  P    + P P
Sbjct: 703  TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP----KKPAP 758

Query: 285  QRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLY 344
            +        +      G  S  S++       AP T  ET  T P      +P   +   
Sbjct: 759  KE-------LAPTTTKGPTSTTSDK------PAPTTPKETAPTTPKEPAPTTPKKPAPTT 805

Query: 345  PSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADE 404
            P + P ++                             + V  P  T  P       T   
Sbjct: 806  PETPPPTT-----------------------------SEVSTPTTTKEP-------TTIH 829

Query: 405  KRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAK 464
            K       E+  E  P AL     N  +EP      +PAA +   PE  +  K    +  
Sbjct: 830  KSPDESTPELSAEPTPKAL----ENSPKEPGVPTTKTPAATK---PEMTTTAKDKTTERD 882

Query: 465  PKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTN 524
             +  P    +               +M K    ++  T E ++  + T  + S+    T 
Sbjct: 883  LRTTPETTTAAP-------------KMTKETATTTEKTTE-SKITATTTQVTSTTTQDTT 928

Query: 525  APGAFRVAS-RSPARTPPASLYHGYLPENGVL-RPEPTKQPPYQLRPSLFVLSPIKEPAK 582
                F++ + ++    P  +     +    ++ +PE T +P  +   S       ++P K
Sbjct: 929  P---FKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK 985

Query: 583  VSPRAASPAKPSSLDLVPNLPKGALPPSP 611
               +  S  KP ++   P + K    P+P
Sbjct: 986  APKKPTSTKKPKTM---PRVRKPKTTPTP 1011


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 132/666 (19%), Positives = 210/666 (31%), Gaps = 71/666 (10%)

Query: 46  QNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTP-TSNSSHNPPATDVNQNPPATV 104
           +NR  ++ +P PP  +      +    L +    +TTP TS + HN  +T         +
Sbjct: 205 KNRTKKKPTPKPPVVD------EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPI 258

Query: 105 VPQ-SLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCS---TLLIDKV 160
            P+ SLP +S    S E  L  N         T   + Q     +E   S   T  I+K 
Sbjct: 259 NPRPSLPPNS--DTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT 316

Query: 161 S--------------TPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTL--VVS 204
           S              TP   T+T     T      P      +S+   +  P T+    +
Sbjct: 317 SAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT 376

Query: 205 ADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPG-GTSQMERSPMLERR 263
             +E +     + PT        T  +P     +   P   + P   T++   +   E  
Sbjct: 377 TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 436

Query: 264 HFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTE 323
               K PAP  P  P  +P   +     +P        + +P + + P       P  T 
Sbjct: 437 PTTPKKPAPTTPKEP--APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTT 494

Query: 324 TLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPAS---KTGILEESMARRGSRKSM 380
               AP      +P +     P++  + +    ++ P +         +S        S 
Sbjct: 495 PKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 554

Query: 381 FTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPR--D 438
            T  E    TP        +       +        E  P      A    +EPAP    
Sbjct: 555 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK 614

Query: 439 RASPAAAEEVVPEWASCLKSPRIQAKPKP------------KPNQNLSEASGKGAELYAR 486
             +P   +++ P     L +P    KP P            +P     E         A 
Sbjct: 615 ETAPTTPKKLTPTTPEKL-APTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA 673

Query: 487 RQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYH 546
             +  E          P   + P+PT    ++   PT   G      + PA T P     
Sbjct: 674 PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA---PTTPKGTAPTTLKEPAPTTPKK--- 727

Query: 547 GYLPENGVLRPEPTKQP-------PYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLV 599
              P    L P  TK+P       P    P     +  KEPA  +P+  +P  P      
Sbjct: 728 ---PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG--TA 782

Query: 600 PNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAK 659
           P   K   P +P  P P   +P   T+ G  S      +P    + +P +P    +P   
Sbjct: 783 PTTLKEPAPTTPKKPAPKELAP--TTTKGPTSTTSDKPAPTTPKETAPTTPKEP-APTTP 839

Query: 660 QAPRPS 665
           + P P+
Sbjct: 840 KKPAPT 845



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 129/666 (19%), Positives = 201/666 (30%), Gaps = 78/666 (11%)

Query: 5   SEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHS 64
           S+E SL  + E     +E          +    T +        +      AP    +  
Sbjct: 271 SKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK 330

Query: 65  PAADVNQNLASPSATLTT-PTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQL 123
           P          P+ T    PT  +   P +T   +  P T+  +S P +   +  +    
Sbjct: 331 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI--KSAPTTP--KEPAPTTT 386

Query: 124 PSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS--TFSREATLIPSSR 181
            S  T P     T   +  P  P E    +T    K   P TT S  T  +E       +
Sbjct: 387 KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTT----KEPAPTTTKSAPTTPKEPAPTTPKK 442

Query: 182 PPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTAR 241
           P  +     +     +P           +   A TTP +          KP     +   
Sbjct: 443 PAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP---KKPAPTTPKEPA 499

Query: 242 PFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPP-SLPDRSPRPQRHIMSRSPMVERRMM 300
           P   + P  T+  E SP         K PAP    S P  +  P       +P   +   
Sbjct: 500 PTTPKEPAPTTTKEPSPTTP------KEPAPTTTKSAPTTTKEPAPTTTKSAPTTPK--- 550

Query: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSD----PKSSHLKG 356
            + SP + + P       P  T     AP      +P +     P++     P +     
Sbjct: 551 -EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 609

Query: 357 QAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGV 416
              P        + +      K   T  EKP  T   +L     T +E      +     
Sbjct: 610 PTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT--TPEEPTPTTPE----- 662

Query: 417 EEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEA 476
           E  P    A A N  +EPAP     PA               P    +P P   +  +  
Sbjct: 663 EPAPTTPKAAAPNTPKEPAPTTPKEPA---------------PTTPKEPAPTTPKETAPT 707

Query: 477 SGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSP 536
           + KG      ++              P   + P+P    P++ K PT+           P
Sbjct: 708 TPKGTAPTTLKEP------------APTTPKKPAPKELAPTTTKEPTST------TCDKP 749

Query: 537 ARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSL 596
           A T P     G  P         T + P    P     + +KEPA  +P+     KP+  
Sbjct: 750 APTTPK----GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK-----KPAPK 800

Query: 597 DLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSP 656
           +L P   KG    +   P P+       T+P + +        P   +  P + S   +P
Sbjct: 801 ELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTP 860

Query: 657 RAKQAP 662
              + P
Sbjct: 861 TTTKEP 866



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 124/618 (20%), Positives = 188/618 (30%), Gaps = 77/618 (12%)

Query: 38  TANGLHLSQNREAQQSSPAPP-------PAEVHSPAADVNQNLASPSATLTTPTSNSSHN 90
           T  G  L+  +E   ++P  P       P      +A       +P+ T + PT+     
Sbjct: 338 TTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA 397

Query: 91  PPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEV 150
           P  T      PA   P+  P  +  +  +     S  T P     T      P  P E  
Sbjct: 398 PTTT----KEPAPTTPKE-PAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 452

Query: 151 RCS----TLLIDKVSTPATT--TSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVS 204
             +    T    K   P T     T  +E       +P  +     +     +P      
Sbjct: 453 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 512

Query: 205 ADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRH 264
                + +  A T TK       T  K P+     + P   + P  T+  E +P      
Sbjct: 513 EPSPTTPKEPAPTTTKSAP----TTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTP--- 565

Query: 265 FGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTET 324
              K PAP  P  P  +P   +     +P        + +P + ++P       P  T  
Sbjct: 566 ---KEPAPTTPKKP--APTTPKEPAPTTPK-------EPAPTTTKKPAPTTPKEPAPTTP 613

Query: 325 LSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFV 384
             TAP      +P +   L P++  K         PA  T    E +A     +   T  
Sbjct: 614 KETAPTTPKKLTPTTPEKLAPTTPEK---------PAPTT---PEELAPTTPEEPTPTTP 661

Query: 385 EKPKVT------PNPDLLDLVQTADEKRRQRDQGEVGV---EEEPFALGAEASNFQQEPA 435
           E+P  T      PN        T  E      +        E  P      A    +EPA
Sbjct: 662 EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA 721

Query: 436 PRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYV 495
           P     PA  +E+ P   +  K P      KP P      A     E      +  E   
Sbjct: 722 PTTPKKPAP-KELAP---TTTKEPTSTTCDKPAPTTPKGTAPTTPKE--PAPTTPKEPAP 775

Query: 496 IESSSHTPELARCPSPTMSLPSSWKY--PTNAPGAFRVASRSPARTPPASLYHGYLPENG 553
                  P   + P+PT     + K   PT   G     S  PA T P         E  
Sbjct: 776 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA 835

Query: 554 VLRPEP----TKQPPYQLRPSLFVLSPIKEPAKV-------SPRAASPAKPSSLDLVPNL 602
              P+     T + P      +   +  KEP  +       +P  ++   P +L+  P  
Sbjct: 836 PTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE 895

Query: 603 PKGALPPSPALPRPSRSS 620
           P      +PA  +P  ++
Sbjct: 896 PGVPTTKTPAATKPEMTT 913



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 108/569 (18%), Positives = 183/569 (32%), Gaps = 116/569 (20%)

Query: 50   AQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
            A  ++  P P     PA    +  A  +    TPT+     P   +     PA   P+ L
Sbjct: 593  APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE----KPAPTTPEEL 648

Query: 110  -PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS 168
             P +  +   +  + P+  T  A+ P+T      P+ PA             +TP     
Sbjct: 649  APTTPEEPTPTTPEEPAPTTPKAAAPNT------PKEPAP------------TTPKEPAP 690

Query: 169  TFSREA--TLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVH 226
            T  +E   T    + P      + + L +  P T    A +E++       PT       
Sbjct: 691  TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-------PTTTKEPTS 743

Query: 227  FTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGE--KAPAPQPPSLPDRSPRP 284
             T  KP     +   P   + P  T+  E +P   +       K PAP  P    + P P
Sbjct: 744  TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTP----KKPAP 799

Query: 285  QRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLY 344
            +        +      G  S  S++       AP T  ET  T P      +P   +   
Sbjct: 800  KE-------LAPTTTKGPTSTTSDK------PAPTTPKETAPTTPKEPAPTTPKKPAPTT 846

Query: 345  PSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADE 404
            P + P ++                             + V  P  T  P       T   
Sbjct: 847  PETPPPTT-----------------------------SEVSTPTTTKEP-------TTIH 870

Query: 405  KRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAK 464
            K       E+  E  P AL     N  +EP      +PAA +   PE  +  K    +  
Sbjct: 871  KSPDESTPELSAEPTPKAL----ENSPKEPGVPTTKTPAATK---PEMTTTAKDKTTERD 923

Query: 465  PKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTN 524
             +  P    +               +M K    ++  T E ++  + T  + S+    T 
Sbjct: 924  LRTTPETTTAAP-------------KMTKETATTTEKTTE-SKITATTTQVTSTTTQDTT 969

Query: 525  APGAFRVAS-RSPARTPPASLYHGYLPENGVL-RPEPTKQPPYQLRPSLFVLSPIKEPAK 582
                F++ + ++    P  +     +    ++ +PE T +P  +   S       ++P K
Sbjct: 970  P---FKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK 1026

Query: 583  VSPRAASPAKPSSLDLVPNLPKGALPPSP 611
               +  S  KP ++   P + K    P+P
Sbjct: 1027 APKKPTSTKKPKTM---PRVRKPKTTPTP 1052


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 163/714 (22%), Positives = 232/714 (32%), Gaps = 147/714 (20%)

Query: 52  QSSPAPPPAEVH---------SPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPA 102
           ++ P PPP             SP       LA PS +   P+  +  +PPAT  +Q PP+
Sbjct: 313 KARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPS-APPSLQTLPSPPATPPSQAPPS 371

Query: 103 TVVPQSLPLSSIQQNSSEAQLPSNGTGPASKP-------STLCADGQPQAPAEEVRCSTL 155
              P      S+Q      Q+P + T P+ +        S+L A     +P  +   S L
Sbjct: 372 MTTPPMQAPPSLQ-TIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFL 430

Query: 156 LIDKVSTPATTTSTFSREATLIPSSRP-------PASDFMSSSLLIDIQP--NTLVVSAD 206
            +    T A+ TS  SR A+  P S P       PAS  + +SL   + P  + L +   
Sbjct: 431 TMSPRQTQASLTSP-SRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPL 489

Query: 207 QEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGG---TSQMERSPMLERR 263
           Q +S  A+ +    + S     L  PP     +  P  +Q P     T  +E  P L   
Sbjct: 490 QALSSLASHSPQAPLSS-----LIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPP 544

Query: 264 HFG-----------EKAPAPQP-----PSLPDRSPRPQRHIMSRSP-------MVERRMM 300
                         E  P P P     P  P  +P P+      +P       +    + 
Sbjct: 545 PLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQ 604

Query: 301 GQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP 360
           G  SP     PL     PP         P      SPP+   L P + P       QA  
Sbjct: 605 GLPSP-----PLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSP-----QAPN 654

Query: 361 ASKTGILEESMARRGSR--KSMFTFVEKPKVTPN--------PDLLD---LVQTADEKRR 407
           A    +L+   +   S   ++ F+    P V+P+        P L      V  +     
Sbjct: 655 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 714

Query: 408 QRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKP 467
                     + P  L A        P      SP+A     P     L +P +Q  P P
Sbjct: 715 PMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPP--PRVPPLLAAPPLQVPPSP 772

Query: 468 KPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPG 527
             +  +S  +    +                +  TP L   PSP  S P    +  +A  
Sbjct: 773 PASLPMSPLAKPPPQA-------------PPALATPPLQALPSPPASFPGQAPFSPSAS- 818

Query: 528 AFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFV-LSPIKEPAKVSPR 586
                  SP  TP                  P + PP    P L V  SP   P   +PR
Sbjct: 819 ----LPMSPLATP------------------PPQAPPVLAAPLLQVPPSPPASPTLQAPR 856

Query: 587 AASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSP-----------------GQ 629
                 P +    P L     P  P  P PSRS     + P                 G 
Sbjct: 857 RPPTPGPDTSVSGPRLTLALAPGPP--PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGY 914

Query: 630 DSLQP--TAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVWKPS 681
           DS      A SPP   +++   P+ AWS    + P P  + R A      W P+
Sbjct: 915 DSGPEGGAAASPPPDAELAACHPA-AWS----RGPAPPLAFRGAPGAPLPWPPA 963



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 112/459 (24%), Positives = 169/459 (36%), Gaps = 64/459 (13%)

Query: 231 KPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHF--GEKAPAPQPPSLPDRSP-RPQRH 287
           +PP  V     P  ++  G    + R P+ ER     G   P   P + P RS     R+
Sbjct: 34  RPPPPVT----PAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRN 89

Query: 288 IMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASW---VRSPPSYSVLY 344
             SR P   R   G+R+P ++    G  ++P   + T    PL      + +  + +   
Sbjct: 90  PASRPPASGR---GERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGK 146

Query: 345 PSSDPKSSHLKGQA---VPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQT 401
            +  PK S L   A         G    +MARR   ++  T V  P+  P P       T
Sbjct: 147 ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS--RAAGTEVGLPR--PAPSARPRPPT 202

Query: 402 ADEKRRQRDQGEVGVEEEPFALGAE--ASNFQQEPAPRDRASPA----AAEEVVPEWASC 455
              ++      E    E   A      A    Q PA R  +S A    +     P     
Sbjct: 203 EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGT 262

Query: 456 LKSPRIQAKPKPK------------PNQNLSEASG--KGAELYARRQSRMEKYVIE--SS 499
            ++P   ++PKPK            P ++ + A G    + L     S  +   +    +
Sbjct: 263 PRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDN 322

Query: 500 SHTPELARCP-SPTMSLPSSWKYPT-NAPGAFRVASRSPARTPPASLYHGYLPENGVLRP 557
           + TP  A  P SP ++ P     P+ +AP + +     PA TPP+              P
Sbjct: 323 AATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPA-TPPSQA------------P 369

Query: 558 EPTKQPPYQLRPSLFVLSPIKEP-AKVSPRAASPAKP---SSLDLVPNLPKGALPPSPA- 612
                PP Q  PSL  + PI+ P +  SP   +P  P   SSL    +L    L  + + 
Sbjct: 370 PSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSF 429

Query: 613 LPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDIS-PVSP 650
           L    R +    TSP + +  P   SPP    +S P SP
Sbjct: 430 LTMSPRQTQASLTSPSRPASTPPD-SPPLQAPLSLPASP 467



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 156/690 (22%), Positives = 226/690 (32%), Gaps = 98/690 (14%)

Query: 58  PPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQN 117
           PPA+  SP    +   AS   T   P         A +      AT  P+   LS+  + 
Sbjct: 104 PPAKNTSPGPVSSPGRAS-GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARR 162

Query: 118 SSEAQLPSNGTGPASKPSTLCAD--GQPQ-APAEEVRCSTLLIDKVSTPATTTSTFSREA 174
            +    P   +   ++ S       G P+ AP+   R  T        P  + S+ S  +
Sbjct: 163 DTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPT------EGPRKSVSSASEHS 216

Query: 175 TLIPSS----RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLA 230
           T  PS     RP A   +       +  +   +S+    SG +A  TP    +  H +  
Sbjct: 217 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPAR-SGPSARGTPR---APAHPSQP 272

Query: 231 KP-------------------PSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPA 271
           KP                   P++   ++ P    +P GT   +  P+    +     PA
Sbjct: 273 KPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGT---KARPVPPPDNAATPLPA 329

Query: 272 PQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLA 331
             PPS P  +P P       +P   + +    +    + P    T P     +L T P  
Sbjct: 330 TLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPI 389

Query: 332 SWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSM--FTFVEKPKV 389
               S  S S+  P S    S L+      S T     S      R++    T   +P  
Sbjct: 390 QVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPAS 449

Query: 390 TPNPDLLDLVQTADEKRRQRDQGEVGVEEEPF----------ALGAEASNFQQEP----- 434
           TP PD   L            Q  +     P           AL + AS+  Q P     
Sbjct: 450 TP-PDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLI 508

Query: 435 ----------APRDRASPAAAEEVVP-EWASCLKSPRIQAKPKPKPNQNLSEASGKGAEL 483
                     AP    +P A+    P E    L  P +Q    P    +L          
Sbjct: 509 MPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCP 568

Query: 484 YARRQSRMEKYVIESSSH-------------TPELARCPSPTMSLPSSWKYPTNAPGAFR 530
                S +     E+ S              +P L   PSP +S  ++   P  AP    
Sbjct: 569 LQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLAT--PPPQAPPXLA 626

Query: 531 V----ASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAK--VS 584
           +    A  SP  +PP S      P+          Q P+   PS  V +P   PA   VS
Sbjct: 627 LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 686

Query: 585 PRAASPAK-PSSLDL----VPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSP 639
           P A  P++ P SL      VP  P  + P SP+   P ++ P L   P Q    P A SP
Sbjct: 687 PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPA-SP 745

Query: 640 PYGGDISPVS--PSRAWSPRAKQAPRPSFS 667
           P     +P    P    +P  +  P P  S
Sbjct: 746 PMSPSATPPPRVPPLLAAPPLQVPPSPPAS 775



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 59/234 (25%), Positives = 86/234 (36%), Gaps = 14/234 (5%)

Query: 437 RDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVI 496
           RD+A   AA       A  L +PR    P+P P    +     GA     R+   E+   
Sbjct: 5   RDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG 64

Query: 497 ESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRS-PARTPPASLYHGYLPENGVL 555
              +  PE A    PT S  +S + P + P A     R+ PA+             +G  
Sbjct: 65  IGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTT 124

Query: 556 RPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPR 615
           RP P  Q   ++     V    +  A  +P+ ++ +  +  D     P     PSPA+ R
Sbjct: 125 RPGPLGQKGLRISAEETV---ARGKATEAPKRSALSAGARRDTSGPTPG---TPSPAMAR 178

Query: 616 PSRSSPGLYTSPGQDSLQPTA-VSPPYGG---DISPVSPSRAWSPRAKQAPRPS 665
            SR++    T  G     P+A   PP  G    +S  S      P      RPS
Sbjct: 179 RSRAAG---TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPS 229



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 79/323 (24%), Positives = 114/323 (35%), Gaps = 69/323 (21%)

Query: 50  AQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
           A  S  AP    VH   A  +   + P     +P ++   +P AT  +Q PP+   P   
Sbjct: 646 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP--- 702

Query: 110 PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTST 169
           PL          Q+P   + PAS P +  A   PQAP        L    +  P +    
Sbjct: 703 PL----------QVPP--SPPASPPMSPSATPPPQAP------PPLAAPPLQVPPS---- 740

Query: 170 FSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTL 229
                       PPAS  MS S     +   L+ +   ++     A+ P          L
Sbjct: 741 ------------PPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMS-------PL 781

Query: 230 AKPPSVVNRTARPFGIQAPG--GTSQMERSPMLERRHFGEK--APAPQPPSLPDRSPRPQ 285
           AKPP            QAP    T  ++  P       G+   +P+   P  P  +P PQ
Sbjct: 782 AKPPP-----------QAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ 830

Query: 286 RHIMSRSPMVERRMMGQRSPA--SERRP--LGNFTAPPTYTETLSTAPLASWVRSPPSYS 341
              +  +P+++       SP   + RRP   G  T+      TL+ AP       PP   
Sbjct: 831 APPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP------GPPPPP 884

Query: 342 VLYPSSDPKSSHLKGQAVPASKT 364
              PSS      L G +  A+ T
Sbjct: 885 SRSPSSTLSGPDLAGHSSSATST 907


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 115/501 (22%), Positives = 170/501 (33%), Gaps = 80/501 (15%)

Query: 179 SSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPT--------KVYSEVHFTLA 230
           +SRPPAS     +      P            GRA+ TT          ++ +E      
Sbjct: 82  TSRPPASGRGERA-----PPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARG 136

Query: 231 KPPSVVNRTARPFGIQAP-GGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIM 289
           K      R+A   G +    G +    SP + RR          P   P   PRP     
Sbjct: 137 KATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGP 196

Query: 290 SRS-PMVERRMMGQRSPASERRPL--GNFTAPPTYTETLSTAPLASWVRSPPSY-----S 341
            +S          + SPA+ RRP   G    P + + + S  PL+S  RS PS      +
Sbjct: 197 RKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA 256

Query: 342 VLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQT 401
             +PS  PK   L+    P       + +  R+ +  ++      P  TP+P        
Sbjct: 257 PAHPSQ-PKPKGLQALRPP-------QVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSA 308

Query: 402 ADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRI 461
               +           +   +LG+          P    SP A     P+    L  P +
Sbjct: 309 PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP--PQAPPALALPPL 366

Query: 462 QAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKY 521
           QA P P  +  LS  +    +      + +  +++++    P     PSP +  P S   
Sbjct: 367 QAPPSPPASPPLSPLATPSPQA----PNALAVHLLQAPFSPP-----PSPPVQAPFS--- 414

Query: 522 PTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPA 581
                         P  +PP S               P+  PP Q  PSL    P++ P 
Sbjct: 415 --------------PPASPPVS---------------PSATPPSQAPPSL-AAPPLQVPP 444

Query: 582 KVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSP-- 639
             SP A+ P  PS+       P  A PP      P ++ P L T P Q    P A  P  
Sbjct: 445 --SPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQ 502

Query: 640 -PYGGDIS-PVSPSRAWSPRA 658
            P+    S P+SP     P+A
Sbjct: 503 APFSPSASLPMSPLATPPPQA 523



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 113/482 (23%), Positives = 161/482 (33%), Gaps = 62/482 (12%)

Query: 231 KPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMS 290
           +PP  V     P  ++  G    + R P+ ER      A      ++P+ +PR      S
Sbjct: 34  RPPPPVT----PAALRVLGAAGAVGRKPLAER------AGGIGGATIPESAPRAGPTRTS 83

Query: 291 RSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASW---VRSPPSYSVLYPSS 347
           R P   R   G+R+P ++    G  ++P   + T    PL      + +  + +    + 
Sbjct: 84  RPPASGR---GERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATE 140

Query: 348 DPKSSHLKGQA---VPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADE 404
            PK S L   A         G    +MARR   ++  T V  P+  P P       T   
Sbjct: 141 APKRSALSAGARRDTSGPTPGTPSPAMARRS--RAAGTEVGLPR--PAPSARPRPPTEGP 196

Query: 405 KRRQRDQGEVGVEEEPFALGAE--ASNFQQEPAPRDRASPA----AAEEVVPEWASCLKS 458
           ++      E    E   A      A    Q PA R  +S A    +     P      ++
Sbjct: 197 RKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA 256

Query: 459 PRIQAKPKPKPNQNL---------SEASGKGAELYARRQSRMEKYVIESSSHTPELARCP 509
           P   ++PKPK  Q L          +A+     L +   +        S S  P L   P
Sbjct: 257 PAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLP 316

Query: 510 SPTMSLPSSWKYPTNAPGAFRVAS------RSPARTPPASLYHGYL----------PENG 553
           SP  + PS       +P      S       SP  TPP                  P + 
Sbjct: 317 SPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASP 376

Query: 554 VLRP--EPTKQPPYQLRPSLFV--LSPIKEP---AKVSPRAASPAKPSSLDLVPNLPKGA 606
            L P   P+ Q P  L   L     SP   P   A  SP A+ P  PS+       P  A
Sbjct: 377 PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA 436

Query: 607 LPPSPALPRPSRSSP-GLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPS 665
            PP    P P  S P     +P   +  P A  P       P +P    +P  +  P P 
Sbjct: 437 APPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPP 496

Query: 666 FS 667
            S
Sbjct: 497 AS 498



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 146/663 (22%), Positives = 208/663 (31%), Gaps = 141/663 (21%)

Query: 58  PPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQN 117
           PPA+  SP    +   AS   T   P         A +      AT  P+   LS+  + 
Sbjct: 95  PPAKNTSPGPVSSPGRAS-GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARR 153

Query: 118 SSEAQLPSNGTGPASKPSTLCAD--GQPQ-APAEEVRCSTLLIDKVSTPATTTSTFSREA 174
            +    P   +   ++ S       G P+ AP+   R  T        P  + S+ S  +
Sbjct: 154 DTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPT------EGPRKSVSSASEHS 207

Query: 175 TLIPSS----RPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLA 230
           T  PS     RP A   +       +  +   +S+    SG +A  TP    +  H +  
Sbjct: 208 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPAR-SGPSARGTPR---APAHPSQP 263

Query: 231 KPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQ----PPSL-----PDRS 281
           KP  +  +  RP  +  P   +     P+           AP     PPSL     P  +
Sbjct: 264 KPKGL--QALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPAT 321

Query: 282 PRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYS 341
           P  Q      SP ++       SP     PL     PP         P      SPP+  
Sbjct: 322 PPSQATTSLGSPTLQATHSFLPSP-----PLSPLATPPPQAPPALALPPLQAPPSPPASP 376

Query: 342 VLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSR--KSMFTFVEKPKVTPNPDLLDLV 399
            L P + P       QA  A    +L+   +   S   ++ F+    P V+P+       
Sbjct: 377 PLSPLATPSP-----QAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA------ 425

Query: 400 QTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSP 459
                             + P +L A        P      SP+A     P+    L +P
Sbjct: 426 --------------TPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPP--PQAPPPLAAP 469

Query: 460 RIQ-AKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSS 518
            +Q AKP P+    L+                           TP L   PSP  S P  
Sbjct: 470 PLQLAKPPPQAPPALA---------------------------TPPLQALPSPPASFPGQ 502

Query: 519 WKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFV-LSPI 577
             +  +A         SP  TP                  P + PP    P L V  SP 
Sbjct: 503 APFSPSAS-----LPMSPLATP------------------PPQAPPVLAAPLLQVPPSPP 539

Query: 578 KEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSP---------- 627
             P   +PR      P +    P L     P  P  P PSRS     + P          
Sbjct: 540 ASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPP--PPPSRSPSSTLSGPDLAGHSSSAT 597

Query: 628 -------GQDSLQP--TAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVW 678
                  G DS      A SPP   +++   P+ AWS    + P P  + R A      W
Sbjct: 598 STPEELRGYDSGPEGGAAASPPPDAELAACHPA-AWS----RGPAPPLAFRGAPGAPLPW 652

Query: 679 KPS 681
            P+
Sbjct: 653 PPA 655



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 73/316 (23%), Positives = 104/316 (32%), Gaps = 39/316 (12%)

Query: 50  AQQSSPAPP------PAEVHSPAADVNQNL----ASPSATLTTPTSNSSHNPPATDVNQN 99
           A  S P P       P +V  P  D    L    +SP AT +     S   PP+     +
Sbjct: 258 AHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPS 317

Query: 100 PPATVVPQ-SLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLID 158
           PPAT   Q +  L S    ++ + LPS    P + P        PQAP        L + 
Sbjct: 318 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATP-------PPQAP------PALALP 364

Query: 159 KVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTP 218
            +  P +  ++        PS + P +  +         P +  V A          +  
Sbjct: 365 PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPS 424

Query: 219 TKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQ-PPSL 277
               S+   +LA PP  V  +       +P  T   +  P L         P PQ PP+L
Sbjct: 425 ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPAL 484

Query: 278 P----DRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASW 333
                   P P      ++P          SP S   P+     PP     +  APL   
Sbjct: 485 ATPPLQALPSPPASFPGQAPF---------SP-SASLPMSPLATPPPQAPPVLAAPLLQV 534

Query: 334 VRSPPSYSVLYPSSDP 349
             SPP+   L     P
Sbjct: 535 PPSPPASPTLQAPRRP 550



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 59/234 (25%), Positives = 85/234 (36%), Gaps = 23/234 (9%)

Query: 437 RDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVI 496
           RD+A   AA       A  L +PR    P+P P    +     GA     R+   E+   
Sbjct: 5   RDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG 64

Query: 497 ESSSHTPELARCPSPT-MSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVL 555
              +  PE A    PT  S P +      AP A +  S  P  +P  +        +G  
Sbjct: 65  IGGATIPESAPRAGPTRTSRPPASGRGERAPPA-KNTSPGPVSSPGRA--------SGTT 115

Query: 556 RPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPR 615
           RP P  Q   ++     V    +  A  +P+ ++ +  +  D     P     PSPA+ R
Sbjct: 116 RPGPLGQKGLRISAEETV---ARGKATEAPKRSALSAGARRDTSGPTPG---TPSPAMAR 169

Query: 616 PSRSSPGLYTSPGQDSLQPTA-VSPPYGG---DISPVSPSRAWSPRAKQAPRPS 665
            SR++    T  G     P+A   PP  G    +S  S      P      RPS
Sbjct: 170 RSRAAG---TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPS 220


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 129/528 (24%), Positives = 185/528 (35%), Gaps = 76/528 (14%)

Query: 163 PATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPT--- 219
           P  +  T SR     P+SRPPAS     +      P            GRA+ TT     
Sbjct: 79  PTRSAGTSSRN----PASRPPASGRGERA-----PPAKNTSPGPVSSPGRASGTTRPGPL 129

Query: 220 -----KVYSEVHFTLAKPPSVVNRTARPFGIQAP-GGTSQMERSPMLERRHFGEKAPAPQ 273
                ++ +E      K      R+A   G +    G +    SP + RR          
Sbjct: 130 GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL 189

Query: 274 PPSLPDRSPRPQRHIMSRS-PMVERRMMGQRSPASERRPL--GNFTAPPTYTETLSTAPL 330
           P   P   PRP      +S          + SPA+ RRP   G    P + + + S  PL
Sbjct: 190 PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 249

Query: 331 ASWVRSPPSY-----SVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVE 385
           +S  RS PS      +  +PS  PK   L+    P       + +  R+ +  ++     
Sbjct: 250 SSPARSGPSARGTPRAPAHPSQ-PKPKGLQALRPP-------QVTPPRKDAAPALGPLSS 301

Query: 386 KPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEE---PFALGAEASNFQQEPAPRDRASP 442
            P  TP+P      Q             +  +     P A  + ++    +  P   A+P
Sbjct: 302 SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATP 361

Query: 443 AAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHT 502
            +      +  + L SP +QA     P+  LS  +    +                +   
Sbjct: 362 PS------QATTSLGSPTLQATHSFLPSPPLSPLATPPPQA-------------PPALAL 402

Query: 503 PELARCPSPTMSLP-SSWKYPT-NAPGAFRV----ASRSPARTPPASLYHGYLPENGVLR 556
           P L   PSP  S P S    P+  AP A  V    A  SP  +PP        P +    
Sbjct: 403 PPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA-----PFSPPAS 457

Query: 557 P--EPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALP 614
           P   P+  PP Q  PSL    P++ P   SP A+ P  PS+       P  A PP     
Sbjct: 458 PPVSPSATPPSQAPPSL-AAPPLQVPP--SPPASPPMSPSATPPPQAPPPLAAPPLQLAK 514

Query: 615 RPSRSSPGLYTSPGQDSLQPTAVSP---PYGGDIS-PVSPSRAWSPRA 658
            P ++ P L T P Q    P A  P   P+    S P+SP     P+A
Sbjct: 515 PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQA 562



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 139/654 (21%), Positives = 205/654 (31%), Gaps = 176/654 (26%)

Query: 55  PAPPP-AEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSS 113
           P P P A    P     ++++S S   TT  S ++   P+       PA+         S
Sbjct: 190 PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS--------RS 241

Query: 114 IQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSRE 173
           +  +++    P+  +GP+++       G P+APA   +     +  +  P  T       
Sbjct: 242 LSSSATPLSSPAR-SGPSAR-------GTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAA 293

Query: 174 ATLIP-SSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKP 232
             L P SS P A+   S++L     P          ++ + A   P    S      + P
Sbjct: 294 PALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSP-----SAP 348

Query: 233 PSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRS 292
           PS+    + P     P   +    SP L+  H    +  P PP  P  +P PQ       
Sbjct: 349 PSLQTLPSPP--ATPPSQATTSLGSPTLQATH----SFLPSPPLSPLATPPPQA------ 396

Query: 293 PMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLY----PSSD 348
                       PA    PL    APP+   +   +PLA+     P+   ++    P S 
Sbjct: 397 -----------PPALALPPL---QAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSP 442

Query: 349 PKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQ 408
           P S  ++    P +   +                    P  TP                 
Sbjct: 443 PPSPPVQAPFSPPASPPV-------------------SPSATPP---------------- 467

Query: 409 RDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQ-AKPKP 467
                    + P +L A        P      SP+A     P+    L +P +Q AKP P
Sbjct: 468 --------SQAPPSLAAPPLQVPPSPPASPPMSPSATPP--PQAPPPLAAPPLQLAKPPP 517

Query: 468 KPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPG 527
           +    L+                           TP L   PSP  S P    +  +A  
Sbjct: 518 QAPPALA---------------------------TPPLQALPSPPASFPGQAPFSPSAS- 549

Query: 528 AFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFV-LSPIKEPAKVSPR 586
                  SP  TP                  P + PP    P L V  SP   P   +PR
Sbjct: 550 ----LPMSPLATP------------------PPQAPPVLAAPLLQVPPSPPASPTLQAPR 587

Query: 587 AASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSP-----------------GQ 629
                 P +    P L     P  P  P PSRS     + P                 G 
Sbjct: 588 RPPTPGPDTSVSGPRLTLALAPGPP--PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGY 645

Query: 630 DSLQP--TAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVWKPS 681
           DS      A SPP   +++   P+ AWS    + P P  + R A      W P+
Sbjct: 646 DSGPEGGAAASPPPDAELAACHPA-AWS----RGPAPPLAFRGAPGAPLPWPPA 694



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 73/308 (23%), Positives = 107/308 (34%), Gaps = 37/308 (12%)

Query: 50  AQQSSPAPP--PAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQ 107
           A   S APP  PA  HS  + +   LA+P   L  P+ ++   PP+     +PPAT   Q
Sbjct: 311 AALQSQAPPTLPATPHS--SSLTCQLATP-LPLAPPSPSA---PPSLQTLPSPPATPPSQ 364

Query: 108 -SLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATT 166
            +  L S    ++ + LPS    P + P        PQAP        L +  +  P + 
Sbjct: 365 ATTSLGSPTLQATHSFLPSPPLSPLATP-------PPQAP------PALALPPLQAPPSP 411

Query: 167 TSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVH 226
            ++        PS + P +  +         P +  V A          +      S+  
Sbjct: 412 PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP 471

Query: 227 FTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQ-PPSLP----DRS 281
            +LA PP  V  +       +P  T   +  P L         P PQ PP+L        
Sbjct: 472 PSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQAL 531

Query: 282 PRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYS 341
           P P      ++P          SP S   P+     PP     +  APL     SPP+  
Sbjct: 532 PSPPASFPGQAPF---------SP-SASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASP 581

Query: 342 VLYPSSDP 349
            L     P
Sbjct: 582 TLQAPRRP 589



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 59/234 (25%), Positives = 86/234 (36%), Gaps = 14/234 (5%)

Query: 437 RDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVI 496
           RD+A   AA       A  L +PR    P+P P    +     GA     R+   E+   
Sbjct: 5   RDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG 64

Query: 497 ESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRS-PARTPPASLYHGYLPENGVL 555
              +  PE A    PT S  +S + P + P A     R+ PA+             +G  
Sbjct: 65  IGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTT 124

Query: 556 RPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPR 615
           RP P  Q   ++     V    +  A  +P+ ++ +  +  D     P     PSPA+ R
Sbjct: 125 RPGPLGQKGLRISAEETV---ARGKATEAPKRSALSAGARRDTSGPTPG---TPSPAMAR 178

Query: 616 PSRSSPGLYTSPGQDSLQPTA-VSPPYGG---DISPVSPSRAWSPRAKQAPRPS 665
            SR++    T  G     P+A   PP  G    +S  S      P      RPS
Sbjct: 179 RSRAAG---TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPS 229



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 100/429 (23%), Positives = 150/429 (34%), Gaps = 97/429 (22%)

Query: 268 KAPAPQPPSL----PDRSPRPQRHIMSRSPMV--ERRMMGQRSPASERRPLGNFTAPPTY 321
           + PA + P L    P  SPRP   +   +  V      +G++  A     +G  T P   
Sbjct: 15  RTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIP--- 71

Query: 322 TETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMF 381
                +AP A   RS  + S   P+S P +S    +A PA  T     S   R S  +  
Sbjct: 72  ----ESAPRAGPTRSAGTSS-RNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTR- 125

Query: 382 TFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRD--- 438
                    P P     ++ + E+   R +     +    + GA        P       
Sbjct: 126 ---------PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAM 176

Query: 439 -RASPAAAEEVVPEWASCLKSPRIQAKPKPK---PNQNLSEASGKGAELYARRQSRMEKY 494
            R S AA  EV       L  P   A+P+P    P +++S AS                 
Sbjct: 177 ARRSRAAGTEVG------LPRPAPSARPRPPTEGPRKSVSSAS----------------- 213

Query: 495 VIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRS----------PARTPPASL 544
             E S+  P            P++ + P+   G  R ASRS          PAR+ P++ 
Sbjct: 214 --EHSTTEPS-----------PAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA- 259

Query: 545 YHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRA-ASPAKPSSLDLVPNLP 603
                      R  P + P +  +P    L  ++ P    PR  A+PA      L P   
Sbjct: 260 -----------RGTP-RAPAHPSQPKPKGLQALRPPQVTPPRKDAAPA------LGPLSS 301

Query: 604 KGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPR 663
                PSP+    S++ P L  +P   SL     +P      SP +P    +  +  A  
Sbjct: 302 SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATP 361

Query: 664 PSFSTRNAG 672
           PS +T + G
Sbjct: 362 PSQATTSLG 370


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 157/658 (23%), Positives = 232/658 (35%), Gaps = 114/658 (17%)

Query: 55  PAPPP--AEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDV---NQNPPATVVPQSL 109
           PAP P  AE H           SP    TTP S    NPP+      +++PP +  P+ L
Sbjct: 364 PAPTPLLAERHG---------GSPQPLATTPLSQEPVNPPSEASPTRDRSPPKS--PEKL 412

Query: 110 PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTST 169
           P SS    SSE+  PS      S+ ++   +    APA             S+P +   +
Sbjct: 413 PQSS----SSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREIS-----SSPTSKNRS 463

Query: 170 FSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTL 229
             R       S  P+     S             S      GR+ + TPTK     H   
Sbjct: 464 HGRAKRDKSHSHTPSRRMGRSR------------SPATAKRGRSRSRTPTK---RGHSRS 508

Query: 230 AKPPSVVNRTARPFGI-------------QAPG-----GTSQMERSPMLERRHFGEKAPA 271
             P    +R+A+ +G              Q PG      T +  RS    R     ++PA
Sbjct: 509 RSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPA 568

Query: 272 PQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASER-------RPLGNFTAPPTYTET 324
            +  S   RS  P R   SRS    RR    R+P   R       R   + +  P    +
Sbjct: 569 TRGRS---RSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRS 625

Query: 325 LSTAPL--ASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFT 382
            + +P+   S  RSP   S    S  P          PA +      + ARR  R    T
Sbjct: 626 RTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRT 685

Query: 383 FVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDR--A 440
              + +           ++    RR R               +E  N  +    R R  +
Sbjct: 686 PARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNS 745

Query: 441 SPAAAEEVVPEWAS-CLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESS 499
           SP   +  +    S  L SPR +AK +    ++LS     G+    +++S+       S 
Sbjct: 746 SPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLS-----GSSPCPKQKSQTPPRRSRSG 800

Query: 500 SHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPAR------TPPASLYHGYLPENG 553
           S  P+      P  S  SS   P       +  S++P+R      +P   +  G  P  G
Sbjct: 801 SSQPKAKSRTPPRRSRSSSSPPP-------KQKSKTPSRQSHSSSSPHPKVKSGTPPRQG 853

Query: 554 -VLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPA 612
            +  P+  +Q     R S F  SP  E      ++ +P++ S          G+ PP   
Sbjct: 854 SITSPQANEQSVTPQRRSCFESSPDPE-----LKSRTPSRHSC--------SGSSPPRVK 900

Query: 613 LPRPSRSSPGLYTSPGQDSLQPTAVSP---PYGGDISPVSPSRAWS---PRAKQAPRP 664
              P R SP   +SP Q  ++   +SP    + G  SP SPSR  S   PR  ++  P
Sbjct: 901 SSTPPRQSPSRSSSP-QPKVK-AIISPRQRSHSGSSSP-SPSRVTSRTTPRRSRSVSP 955



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 112/503 (22%), Positives = 184/503 (36%), Gaps = 77/503 (15%)

Query: 230  AKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIM 289
            ++ P V  R +R          S+   SP+  RR     +P  +  S    SP  +R   
Sbjct: 1948 SRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSR 2007

Query: 290  SRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLA-----------------S 332
            SR+  V RR    R+P + RR   + T       + S +PLA                 S
Sbjct: 2008 SRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRS 2067

Query: 333  WVRSPPSYSVLYPSSDPKSSHLKGQAVP---ASKTGILEESMARRGSRKSMFTFVEKPKV 389
              RSPP  ++   S+   SS     A P    + +G     +A   SR S F+   +P +
Sbjct: 2068 LTRSPP--AIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFS---RPSM 2122

Query: 390  TP-------NPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASP 442
            +P       +P +L+ + ++        Q    + + P   G    + Q+   P + A  
Sbjct: 2123 SPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSMMDGP---GPRIPDHQRTSVPENHAQS 2179

Query: 443  AAAEEVV----------PEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRME 492
              A  +           P  ++   + R+   P P P  +L  A    A L +R  +   
Sbjct: 2180 RIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTA--PAANLASRIPAASA 2237

Query: 493  KYVIESSSHTPEL--------ARCPSPTMSLPSSWKYPTNAPGAFRVAS-RSP------- 536
              +  +S+ TP +        +R P+   ++  +      AP A  +A  R+P       
Sbjct: 2238 AAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNL 2297

Query: 537  --ARTPPA----SLYHGYLPENGVLRPEPTKQPPYQLRPSL------FVLSPIKEPAKVS 584
              ARTP A    SL     P      P  ++ P      +L         +P+      +
Sbjct: 2298 AGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRT 2357

Query: 585  PRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGD 644
              A +PA  +S  + P L  GA   SP +P  +       TSP     +  + +PP    
Sbjct: 2358 AAALAPASLTSARMAPAL-SGANLTSPRVPLSAYERVSGRTSPPLLD-RARSRTPPSAPS 2415

Query: 645  ISPVSPSRAWSPRAKQAPRPSFS 667
             S ++  RA SP ++    PS S
Sbjct: 2416 QSRMTSERAPSPSSRMGQAPSQS 2438



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 122/560 (21%), Positives = 206/560 (36%), Gaps = 103/560 (18%)

Query: 50   AQQSSPAPPPA----EVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVV 105
            A   +PA P A    +  +PAA    NLASP  T   P++          VN   P T  
Sbjct: 2243 ASARTPAIPTAVNLADSRTPAAAAAMNLASPR-TAVAPSA----------VNLADPRTPT 2291

Query: 106  PQSLPLSSIQQNSSEAQLPSNGTG-PASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPA 164
              ++ L+  +  ++ A L   G+G P +  +   +   PQAPA     S  L+   S  A
Sbjct: 2292 APAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPA-----SANLVGPRSAHA 2346

Query: 165  TTTSTFSREAT---LIPSSRPPASDFMSSSLL-IDIQPNTLVVSADQEMSGRAAATTPTK 220
            T     +   T   L P+S   A   M+ +L   ++    + +SA + +SGR +     +
Sbjct: 2347 TAPVNIAGSRTAAALAPASLTSAR--MAPALSGANLTSPRVPLSAYERVSGRTSPPLLDR 2404

Query: 221  VYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDR 280
              S        PPS  +++ R    +AP  +S+M +              AP    LP  
Sbjct: 2405 ARSRT------PPSAPSQS-RMTSERAPSPSSRMGQ--------------APSQSLLPPA 2443

Query: 281  SPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSY 340
              +P+  + S      R ++ Q             T P   +++LS+  +A+   S   +
Sbjct: 2444 QDQPRSPVPSAFSDQSRCLIAQ-------------TTPVAGSQSLSSGAVATTTSSAGDH 2490

Query: 341  SVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQ 400
            + +     P         VP S  G   E  A  G+++              P  L  +Q
Sbjct: 2491 NGMLSVPAP--------GVPHSDVG---EPPASTGAQQ--------------PSALAALQ 2525

Query: 401  TADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPR 460
             A E+R                  + +S+     +    +S + +     E +S    P 
Sbjct: 2526 PAKERRSSSSSS------------SSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPE 2573

Query: 461  IQAKPKPKPNQNLSEA--SGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSS 518
            +  K  P P     EA   G+  E    ++ R       SSS +   +   S + S  SS
Sbjct: 2574 VALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSS 2633

Query: 519  WKYPTNAPGAFRVASRSPARTPPASLYHGYLPEN---GVLRPEPTKQPPYQLRPSLFVLS 575
                +++  +   +S SPA+  P +L     P+    G  R    ++P   LR S  +  
Sbjct: 2634 SSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSY 2693

Query: 576  PIKEPAKVSPRAASPAKPSS 595
               E  + SP+ +   + SS
Sbjct: 2694 SPVERRRPSPQPSPRDQQSS 2713



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 62/265 (23%), Positives = 105/265 (39%), Gaps = 37/265 (13%)

Query: 70   NQNLASPSATLTTPTSNSSHNP---------PATDVNQNPPATVVPQSLPLSSIQ----- 115
            +Q+L+S  A  TT +S   HN          P +DV + P +T   Q   L+++Q     
Sbjct: 2472 SQSLSS-GAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKER 2530

Query: 116  -QNSSEAQLPSNGTGPASKPSTLCADG-------------QPQAPAEEVRCSTLL----I 157
              +SS +   S+ +  +S  S+  + G             QP+   + V   T      +
Sbjct: 2531 RSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAV 2590

Query: 158  DKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATT 217
             +   P  T +   R ++   SS   +S   SSS       ++   S+    S  +++ +
Sbjct: 2591 REGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPS 2650

Query: 218  PTKVYSEVHFTLA---KPPSVVNRTARPFG-IQAPGGTSQMERSPMLERRHFGEKAPAPQ 273
            P K   +     A   KPP    R+  P   I +   +  +  SP+  RR   + +P  Q
Sbjct: 2651 PAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQ 2710

Query: 274  PPSLPDRSPRPQRHIMSRSPMVERR 298
              S  +R  R  +   SRSP  +RR
Sbjct: 2711 QSSSSERGSRRGQRGDSRSPSHKRR 2735



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 100/426 (23%), Positives = 146/426 (34%), Gaps = 76/426 (17%)

Query: 258  PMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQR-SPASERRPLG--N 314
            P   +R     +PAP   S    SP   R   SR+P++ RR    R SP S RR     +
Sbjct: 1846 PTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTS 1905

Query: 315  FTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARR 374
             T   + +     +   S  R+PP       S  P +        P          + RR
Sbjct: 1906 VTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTP---------PVTRR 1956

Query: 375  GSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEP 434
             SR         P VT              +RR R +           +    S  +  P
Sbjct: 1957 RSRS------RTPPVT--------------RRRSRSRTS--------PITRRRSRSRTSP 1988

Query: 435  APRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKY 494
              R R S +    V    +    SP  + + + +    +   S     L  R++SR    
Sbjct: 1989 VTR-RRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSP 2047

Query: 495  VI---ESSSHTPELARCP-SPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLP 550
            +     S S TP  AR   S T S P+  +   +A G+   + RS + TPPA+  H    
Sbjct: 2048 LAIRRRSRSRTPRTARGKRSLTRSPPAIRR--RSASGS--SSDRSRSATPPATRNH---- 2099

Query: 551  ENGVLRPEPTKQPPYQL---------RPSL--FVLSPIKEPAKVSPRAASPAKPSSLDLV 599
                     ++ PP  L         RPS+    L   + P  + P  +S    S L   
Sbjct: 2100 -------SGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQA 2152

Query: 600  PNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRA-WSPRA 658
                     P P +P   R+S     +  + +L  TA+S   G    P S S A  + R 
Sbjct: 2153 GGSMMDG--PGPRIPDHQRTSVPENHAQSRIALALTAIS--LGTARPPPSMSAAGLAARM 2208

Query: 659  KQAPRP 664
             Q P P
Sbjct: 2209 SQVPAP 2214



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 61/266 (22%), Positives = 93/266 (34%), Gaps = 23/266 (8%)

Query: 256  RSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNF 315
            R+  + RR    +    +  S    SP  +R   SR+P V RR    R+P + RR     
Sbjct: 1891 RTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSR- 1949

Query: 316  TAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRG 375
            T P T   + S  P  +  RS    S +      + S  +   V   ++      + RR 
Sbjct: 1950 TPPVTRRRSRSRTPPVTRRRSRSRTSPI----TRRRSRSRTSPVTRRRSRSRTSPVTRRR 2005

Query: 376  SRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEV-----GVEEEPFALGAEASNF 430
            SR        +   +  P  +        +RR R +  +          P A+   + + 
Sbjct: 2006 SRSRTSPVTRRRSRSRTPPAI--------RRRSRSRTPLLPRKRSRSRSPLAIRRRSRSR 2057

Query: 431  QQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSR 490
                A   R+   +   +    AS   S R ++   P    +    SG      A   SR
Sbjct: 2058 TPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNH----SGSRTPPVALNSSR 2113

Query: 491  MEKYVIESSSHTPELARCPSPTMSLP 516
            M  +   S S TP L RC SP M  P
Sbjct: 2114 MSCFSRPSMSPTP-LDRCRSPGMLEP 2138



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 78/388 (20%), Positives = 148/388 (38%), Gaps = 32/388 (8%)

Query: 42   LHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSH-NPPATDVNQNP 100
            ++++ +R A   +PA   +   +PA     NL SP   L+     S   +PP  D  ++ 
Sbjct: 2350 VNIAGSRTAAALAPASLTSARMAPALS-GANLTSPRVPLSAYERVSGRTSPPLLDRARSR 2408

Query: 101  PATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLC-ADGQPQAP-----AEEVRCST 154
                 P S P  S +  S  A  PS+  G A   S L  A  QP++P     +++ RC  
Sbjct: 2409 ----TPPSAPSQS-RMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLI 2463

Query: 155  LLIDKVS--------TPATTTSTFSREATL--IPSSRPPASDFMSSSLLIDIQPNTLVVS 204
                 V+          ATTTS+      +  +P+   P SD          Q  + + +
Sbjct: 2464 AQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAA 2523

Query: 205  ADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRH 264
                   R+++++ +   S    + +   S  + ++      +    S +   P +  + 
Sbjct: 2524 LQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSS-----SSDSEGSSLPVQPEVALKR 2578

Query: 265  FGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTET 324
                 PAP+      R P P      R            S +S      + ++  + + +
Sbjct: 2579 VPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2638

Query: 325  LSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESM-ARRGSRKSMFTF 383
             S++  +S   S PS +   P + PK +  K       ++    + + + R SR   ++ 
Sbjct: 2639 SSSSSSSS---SSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSP 2695

Query: 384  VEKPKVTPNPDLLDLVQTADEKRRQRDQ 411
            VE+ + +P P   D   ++ E+  +R Q
Sbjct: 2696 VERRRPSPQPSPRDQQSSSSERGSRRGQ 2723



 Score = 37.0 bits (84), Expect = 0.061
 Identities = 80/347 (23%), Positives = 140/347 (40%), Gaps = 56/347 (16%)

Query: 212  RAAATTPTKVYSEV-----HFTLAKPPSVVNRTA-RPFGIQAPGGTSQMERSPMLERRHF 265
            R++++ P K  S+      H + +  P V + T  R   I +P      E+S   +RR  
Sbjct: 816  RSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQAN---EQSVTPQRRSC 872

Query: 266  GEKAPAPQPPSLPDRSPRPQRHIMSRS--PMVERRMMGQRSPASERRPLGNFTA---PPT 320
             E +P P+      +S  P RH  S S  P V+     ++SP+    P     A   P  
Sbjct: 873  FESSPDPEL-----KSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQ 927

Query: 321  YTETLSTAPLASWVRS---PPSYSVLYPSSD------PKSSHLKGQAVPASKTGILEESM 371
             + + S++P  S V S   P     + P S+      P+ SH  G + P +K  +  E+ 
Sbjct: 928  RSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSH-SGSSSPDTK--VKPETP 984

Query: 372  ARRGSRKSMFTFVE-KPKVTPNPDLLDLVQTADEKRRQRDQGE---------VGVE---- 417
             R+    S+  + + K +  P P L        +++ +    +          GV+    
Sbjct: 985  PRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTP 1044

Query: 418  --EEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSE 475
              E  F + +     Q + +P D  S  ++ EV    +   +SP +Q+K +  P    S 
Sbjct: 1045 PGESYFGVSSLQLKGQSQTSP-DHRSDTSSPEVRQSHS---ESPSLQSKSQTSPKGGRSR 1100

Query: 476  ASGKGAELYARRQSRMEKYVIES-----SSHTPELARCPSPTMSLPS 517
            +S    EL +R   R ++    +     S  +PE +R  S + S P+
Sbjct: 1101 SSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPT 1147



 Score = 36.6 bits (83), Expect = 0.079
 Identities = 69/309 (22%), Positives = 109/309 (35%), Gaps = 48/309 (15%)

Query: 404 EKRRQRDQGEVGVEEEPFALGAEASN-----FQQEPAPRDRASPAAAEEVVPEWASCLKS 458
           +K++++D+G       P     ++S       + E   R   SP    +   +     +S
Sbjct: 189 KKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRS 248

Query: 459 PRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELA-RCPSPTMSLPS 517
                 PK +     + A    +   +R +SR       + +HT  LA R PSP      
Sbjct: 249 RSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAA----AKTHTTALAGRSPSPASGRRG 304

Query: 518 SWKYPTNAPGAF---RVASRSPARTPPASLYHGY---LPENGVLRPEPTKQ--------- 562
               P + PG     R +S   A   P+S Y        E    RP P+ +         
Sbjct: 305 EGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPP 364

Query: 563 ------------PPYQLRPSLFVLSPIKEPAKVSP-RAASPAKPSSLDLVPNLPKGALPP 609
                        P  L  +     P+  P++ SP R  SP K S   L  +    + PP
Sbjct: 365 APTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPK-SPEKLPQSSSSESSPP 423

Query: 610 SPALPRPSR------SSPGLYTSPG---QDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQ 660
           SP   + SR       SP    +PG   + S  PT+ +  +G      S S   S R  +
Sbjct: 424 SPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGR 483

Query: 661 APRPSFSTR 669
           +  P+ + R
Sbjct: 484 SRSPATAKR 492



 Score = 36.6 bits (83), Expect = 0.079
 Identities = 147/685 (21%), Positives = 235/685 (34%), Gaps = 94/685 (13%)

Query: 33   NAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPP 92
            +A+ +  +G+   Q+R    SS  P          D N +L   S   T  +      PP
Sbjct: 1122 SASPMLKSGMSPEQSRFQSDSSSYP--------TVDSN-SLLGQSRLETAESKEKMALPP 1172

Query: 93   ATDVNQNPP------ATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAP 146
              D   +PP      +    Q  P SS+    +    P   +G  S P T   +      
Sbjct: 1173 QEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTS 1232

Query: 147  AEEVRCSTLLIDKVSTPATT-----TSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTL 201
            +++     + ++K   PA       +S     +T    S P   +  + SL +D   +  
Sbjct: 1233 SQDEELMEV-VEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQA 1291

Query: 202  VVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVN--------RTARPFGIQAPGGTS- 252
             + A +  S  ++   P   +S  H  L+  P   N        R + P G +   G S 
Sbjct: 1292 SLEAVEVPSMASSWGGPH--FSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSS 1349

Query: 253  ------------QMERSPMLERRHFGEKAPAPQPPSLPDRSPRP-QRHIMSRSPMVERRM 299
                        Q+E  P L+ +   E++      S  + SP   ++  MS +  +   +
Sbjct: 1350 EVKEDLNGPFLNQLETDPSLDMK---EQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPV 1406

Query: 300  MGQ--RSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQ 357
            +    R+P+ ER    +  + P   + L   P +   RS  S  +   S  P    L G 
Sbjct: 1407 LDAVPRTPSRER---SSSASSPEMKDGLPRTP-SRRSRSGSSPGLRDGSGTPSRHSLSGS 1462

Query: 358  AVPASKTGILEESMARRGSR-KSMFTFVEKPKVTP--------NPDLLDLVQTADEKRRQ 408
            + P  K       + R  SR +S      +PK  P        +P   +L       +R+
Sbjct: 1463 S-PGMK------DIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRE 1515

Query: 409  RDQGEVGVEEEPFA---LGAEA-SNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAK 464
            R   E  V+++  A   LG  + S   QE   +  ASP    E          SP  +AK
Sbjct: 1516 RSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESD-------SSPDSKAK 1568

Query: 465  PKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCP--SPTMSLPSSWKYP 522
             +    Q     S    +  +R   R  +     S  +PE+   P  +P     S     
Sbjct: 1569 TRTPLRQRSRSGSSPEVDSKSRLSPRRSR-----SGSSPEVKDKPRAAPRAQSGSDSSPE 1623

Query: 523  TNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQL---RPSLFVLSPIKE 579
              AP    +  RS  R+  +S   G  PE         + PP      R S     P K 
Sbjct: 1624 PKAPAPRALPRRS--RSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEP-KT 1680

Query: 580  PAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSP 639
             ++  PR  S      L     L + +   S +    SR+ P    SP   S +P   S 
Sbjct: 1681 KSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSR 1740

Query: 640  PYGGDISPVSPSRAWSPRAKQAPRP 664
                  S  SP    + R  ++P P
Sbjct: 1741 SSRRRRSASSPRTKTTSRRGRSPSP 1765



 Score = 33.1 bits (74), Expect = 0.88
 Identities = 72/317 (22%), Positives = 110/317 (34%), Gaps = 54/317 (17%)

Query: 261 ERRHFGEKAPAPQPP--------SLPDRSPRPQ-----------RHIMSRSPMVERRMMG 301
           +RR    K PAP+PP        S   RSP P+           R   S SP  ER+   
Sbjct: 154 QRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSS 213

Query: 302 Q----RSPASERRPLGNFTAPPTYTE--------TLSTAPLASWVRSPPSYSV-LYPSSD 348
           +    RS +  ++       P +  +        + ST P     R+  S S     SSD
Sbjct: 214 KKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSD 273

Query: 349 PKSSHLKGQAVPASKTGILEES----MARRGSRKSMF-----TFVEKPKVTPNPDLLDLV 399
              S  +  A     T +   S      RRG   + F     T  ++P    +P+     
Sbjct: 274 TSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPS---SPETATKQ 330

Query: 400 QTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSP 459
            ++  + + +D+ E      P      +S   + PAP    +        P   + L   
Sbjct: 331 PSSPYEDKDKDKKEKSA-TRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQE 389

Query: 460 RIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSW 519
            +    +  P ++ S    K  E   +  S       ESS  +P+  +      S P S 
Sbjct: 390 PVNPPSEASPTRDRSPP--KSPEKLPQSSSS------ESSPPSPQPTKVSRHASSSPESP 441

Query: 520 KYPTNAPGAFRVASRSP 536
           K P  APG+ R  S SP
Sbjct: 442 K-PAPAPGSHREISSSP 457


>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
          Length = 1682

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 141/625 (22%), Positives = 216/625 (34%), Gaps = 108/625 (17%)

Query: 92  PATDVNQNPPA-TVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEV 150
           PA     +PP   +VP + P    +   +E    S+G  PA++P        P +   E 
Sbjct: 316 PAPAYTAHPPGHRLVPAAPPGPGPRPPGAE----SHGCLPATRP--------PGSDLRES 363

Query: 151 RCSTLLIDKVSTPATTTSTF----SREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSAD 206
           R     +D   +PA TT+      SR   L  ++   +S   S++ L  ++PN  +  AD
Sbjct: 364 RVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGAD 423

Query: 207 QEMS--------GRA--AATTPTKVY-----SEVHFTL-----AKPPSVVNRTARP---- 242
              +        GR   +A +  K +     +  H +L     + PP    R  RP    
Sbjct: 424 HYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPCPRLLRPPPPP 483

Query: 243 FGIQAPGGTSQMERSPMLERRHFG-EKAPAPQPPSLPDRS----PRPQR--------HIM 289
             ++ P   +  E   +LE   FG E  P P PP LP R     P   R        H  
Sbjct: 484 AWLKGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTP 543

Query: 290 SRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDP 349
              P          S +    P G  + PP      S  PL      PPS     P+ +P
Sbjct: 544 PTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPR----PPS-----PAQNP 594

Query: 350 KSSHLKG------QAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTAD 403
           +   L         A P+S       S  R  S +   +F + P+V P P    L +   
Sbjct: 595 QDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAPQ 654

Query: 404 EKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQA 463
                      GV E P A G    +F   P       PA  + +    A+ +K   +  
Sbjct: 655 PV-------PPGVGELP-ARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKM--LDE 704

Query: 464 KPKPKPNQNLSEASGKGAELYARRQSRMEKYV-IESSSHTPELARCPSPTMSLPSSWKYP 522
             + +  Q   EA        A +    E +  ++S   T       +P +++ ++    
Sbjct: 705 SIRKEEEQQQHEAG------VAPQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTT 758

Query: 523 TNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAK 582
           T          + P   PP      + P +   +P+P   PP      L  L+ + E  K
Sbjct: 759 TTTTATQEEEKKPPPALPPPPPLAKFPPPS---QPQPPPPPPPSPASLLKSLASVLEGQK 815

Query: 583 VSPRAA----------------SPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLY-T 625
              R                  SP  PS    +P  P  A P +   P+PS SS   + T
Sbjct: 816 YCYRGTGAAVSTRPGPLPTTQYSPGPPSGATALP--PTSAAPSAQGSPQPSASSSSQFST 873

Query: 626 SPGQDSLQPTAVSPPYGGDISPVSP 650
           S G  + +  A   P  G ++P  P
Sbjct: 874 SGGPWARERRAGEEPVPGPMTPTQP 898



 Score = 29.6 bits (65), Expect = 9.7
 Identities = 21/66 (31%), Positives = 25/66 (37%), Gaps = 9/66 (13%)

Query: 599 VPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRA 658
           +P  P    PP P  P P    PGL TSP     +P   S  +G          AW P  
Sbjct: 244 LPLPPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGD---------AWGPER 294

Query: 659 KQAPRP 664
           K +  P
Sbjct: 295 KGSAPP 300


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 160/672 (23%), Positives = 230/672 (34%), Gaps = 103/672 (15%)

Query: 54   SPAPPPAEVHSPAADVNQNLASPSATLT-----TPTSNSSHNPPATDVNQNP-------P 101
            +P PP A    P +     + +P  TLT     TPT  ++  P  T     P       P
Sbjct: 1322 TPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSP 1381

Query: 102  ATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDK-- 159
            +  V  S P ++    SS   +PS+  GPAS P  +  +  P A       S  L     
Sbjct: 1382 SPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPI-PNSSPLASPVSSTVSVPLSSSLP 1440

Query: 160  VSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPT 219
            +S P T  +  S   T IP S P        +LL  + P    V          A +  +
Sbjct: 1441 ISVPTTLPAPASAPLT-IPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGAS 1499

Query: 220  KVYSEVHFTLAKPPSVVNRTA-------RPFGIQAPGGTSQMERSPMLERRHFGEKAPAP 272
               S +   LA  PS+ +           P     PG  S +  +P          A A 
Sbjct: 1500 PSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTV--APACSPVLVPASALAS 1557

Query: 273  QPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSP--ASERRPLGNFTAPP-TYTETLSTAP 329
              PS P+ +P  Q  +++ +    + +    +P  A +   L    APP      L+ +P
Sbjct: 1558 PFPSAPNPAP-AQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSP 1616

Query: 330  LASWV--RSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKP 387
             A+ V   S     V+ PSS P +S      VPA  T +L  S        S  T +  P
Sbjct: 1617 GAAPVLASSQTPVPVMAPSSTPGTSLASASPVPA-PTPVLAPS--------STQTMLPAP 1667

Query: 388  KVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEE 447
              +P P        A         G      +  +LG   +   Q P P    S   A  
Sbjct: 1668 VPSPLPSPASTQTLALAPALAPTLGG-SSPSQTLSLG---TGNPQGPFPTQTLSLTPASS 1723

Query: 448  VVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELAR 507
            +VP  A  L    +   P   P Q LS A                       +    +  
Sbjct: 1724 LVPTPAQTLS---LAPGPPLGPTQTLSLAPA------------------PPLAPASPVGP 1762

Query: 508  CPSPTMSL-PSSWKYPTNAPGAFRVASRSPARTP---PASLYHGYLPENGVLRPEPTKQP 563
             P+ T++L P+S      AP + +  + SPA  P   PA+       +   L P  T+ P
Sbjct: 1763 APAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAA------AQTLALAPASTQSP 1816

Query: 564  PYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPAL----PRPSRS 619
              Q   SL V +    P  V+  +  P      D +        PPS A     PRP R 
Sbjct: 1817 ASQ-ASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTATSFGGPRPRRQ 1875

Query: 620  SPGLYTSPGQ-DSLQPT--------------------AVSPPYGGDISP--VSPSRAWSP 656
             P    SP   DSL+                      A++P YG ++      P    SP
Sbjct: 1876 PPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQPVASP 1935

Query: 657  RAKQAPRPSFST 668
               ++P PS  T
Sbjct: 1936 IGPRSPGPSHPT 1947



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 96/380 (25%), Positives = 138/380 (36%), Gaps = 85/380 (22%)

Query: 51   QQSSPAPPPAEVHSPAADVNQNLA----------SPSATLTTPTSNSSHNPPATDVNQNP 100
            Q   PAP P+ + SPA+     LA          SPS TL+  T N     P   ++  P
Sbjct: 1661 QTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTP 1720

Query: 101  PATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTL--CADGQPQAPAEEV---RCSTL 155
             +++VP            + AQ  S   GP   P+     A   P APA  V      TL
Sbjct: 1721 ASSLVP------------TPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTL 1768

Query: 156  LIDKVSTPAT-----TTSTFSREATLIPSSRPPASDFM----SSSLLIDIQPNTLVVSAD 206
             +   S+ A+     +  T +     +P+  P A+  +    +S+     Q ++LVVSA 
Sbjct: 1769 TLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSAS 1828

Query: 207  QEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFG 266
                   AA  P  + S +  +  +P ++  R+  P              SP      FG
Sbjct: 1829 ------GAAPLPVTMVSRLPVSKDEPDTLTLRSGPP--------------SPPSTATSFG 1868

Query: 267  EKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASER----RPLGNFTAPPTYT 322
               P  QPP  P RSP            +E +   QRS   ER           AP   T
Sbjct: 1869 GPRPRRQPPP-PPRSP-------FYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGT 1920

Query: 323  ETLSTAPLASWVRSP-------PSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRG 375
            E L    L   V SP       PS+   +  ++  ++H +    P  +   L E + R  
Sbjct: 1921 EVLDFCTLPQPVASPIGPRSPGPSHPTFWTYTE--AAH-RAVLFPQQRLDQLSEIIER-- 1975

Query: 376  SRKSMFTFVEKPKVTPNPDL 395
                 F FV  P   P P L
Sbjct: 1976 -----FIFVMPPVEAPPPSL 1990



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 51/217 (23%), Positives = 79/217 (36%), Gaps = 44/217 (20%)

Query: 434  PAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEK 493
            PAPR R +PA+A   +P   + +  P     P   PN                  + +  
Sbjct: 2439 PAPRPRPTPASAPAAIP---ALVPVPVSAPVPISAPNP----------------ITILPV 2479

Query: 494  YVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENG 553
            +++ S     ++  C SP  + P +   P             PA TPP +      P + 
Sbjct: 2480 HILPSPPPPSQIPPCSSPACTPPPACTPP-------------PAHTPPPAQTCLVTPSSP 2526

Query: 554  VLRPEPT-------KQPPYQLRPSL-FVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKG 605
            +L   P+          P  LRP        +  P  +   + + ++ SSL LVP  PK 
Sbjct: 2527 LLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELASVASSETSSLSLVP--PKD 2584

Query: 606  ALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYG 642
             LP +  +   S  +  L  +P   SL   A S P G
Sbjct: 2585 LLPVAVEILPVSEKN--LSLTPSAPSLTLEAGSIPNG 2619



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 97/417 (23%), Positives = 151/417 (36%), Gaps = 74/417 (17%)

Query: 35   ALLTANGLHLSQNREAQQSSPA--PP----PAEVHS-PAADVNQNL--ASPSATLTTPTS 85
            AL +   L L+    ++ SS +  PP    P  V   P ++ N +L  ++PS TL   + 
Sbjct: 2557 ALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSI 2616

Query: 86   NSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCAD----- 140
             +     A D  +    TV+P+   L      S+  +LP +          L AD     
Sbjct: 2617 PNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEE 2676

Query: 141  --------GQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSL 192
                      P+ P E      L+  +V+ P+T++S     AT  P    PA        
Sbjct: 2677 LTEAKTPTSSPEKPQE------LVTAEVAAPSTSSS-----ATSSPEGPSPA-------- 2717

Query: 193  LIDIQPNTLVVSADQEM----SGRAAATTPTKVYSEVH---FTLAKPPSVVNRTARPFGI 245
                +P     SAD E+    +GR       KV  ++     T+ +   +V R  +  G 
Sbjct: 2718 ----RPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGA 2773

Query: 246  QA---PG--GTSQMERSPMLERRHFGEKAPAPQPP--SLPDRS-PRPQRHIMSRSPMVER 297
             +   PG   TS    SP +      E +P    P  + P  S P P +        +E 
Sbjct: 2774 ASTLVPGVSETSASPGSPSVRSMSGPESSPPIGGPCEAAPSSSLPTPPQQPFIARRHIEL 2833

Query: 298  RMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQ 357
             + G  SP +    L   T PP         P  +  RSP          +  SS LKG+
Sbjct: 2834 GVTGGGSPENGDGALLAIT-PPAVKRRRGRPPKKN--RSPADAG--RGVDEAPSSTLKGK 2888

Query: 358  A-----VPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQR 409
                  VP  +T I+ + +              +P   PNP    L+   +++RR R
Sbjct: 2889 TNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPNP----LLSPVEKRRRGR 2941



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 41/129 (31%), Positives = 50/129 (38%), Gaps = 37/129 (28%)

Query: 536  PARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLS---------PIKEPAKVSPR 586
            P R PP        PE   L  +PT  P  Q+ P+  ++S         P   P    P 
Sbjct: 1023 PVRPPPG-------PE---LSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPP--GPV 1070

Query: 587  AASPAKPSSLDLVPNLPK--GAL-----PPSPAL------PRPSRSSPGLYTSPGQDS-L 632
               P +P+S  L   LP   G L     PP+P L      P P R SP     PG  S L
Sbjct: 1071 LLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPA--PPPGSSSLL 1128

Query: 633  QPTAVSPPY 641
            +P  V P Y
Sbjct: 1129 KPLTVPPGY 1137



 Score = 29.6 bits (65), Expect = 9.7
 Identities = 28/98 (28%), Positives = 37/98 (37%), Gaps = 8/98 (8%)

Query: 260  LERRHFGEKAPAPQPPSLP-------DRSPRPQRHIMSRSPMVERRMMGQRSPASERRPL 312
            L RR   E A AP PP  P       +R  +P      R+ +V         P   R P 
Sbjct: 969  LSRRVLLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRPPP 1028

Query: 313  G-NFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDP 349
            G   +A PT        P +  V + P+   L P+S P
Sbjct: 1029 GPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRP 1066


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 114/481 (23%), Positives = 171/481 (35%), Gaps = 83/481 (17%)

Query: 234  SVVNRTARPFGIQAPGGTSQ-MERSPMLERRHFGEKAPAPQPPS---------------L 277
            +V  R  R   ++AP G  + + RS     R   +K P P PP                +
Sbjct: 909  TVQRRVGRSHSVRAPAGADKNVNRSQSFAVRP-RKKGPPPPPPKRSSSALASANLADEPV 967

Query: 278  PDRSPRP-----------------------QRHIMSRSPMVERRMMGQRSPASERRPLGN 314
            PD  P                            + S + M+E   +G    A+ R P G+
Sbjct: 968  PDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGH 1027

Query: 315  FTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARR 374
             T  P   E    A + + V+   +     P  +  +   + + +    TG+L  + ARR
Sbjct: 1028 PTPRPASPEPGRVATVLASVKHKEAIG---PGGEVVN---RRRTLSGPVTGLL--ATARR 1079

Query: 375  GSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEP 434
            G  +S           P P + D   T  ++ R   +GE GVE  P A    ++  ++  
Sbjct: 1080 GPGES---------ADPGPFVED--GTGRQRPRGPSKGEAGVEGPPLAKVEASATLKR-- 1126

Query: 435  APRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKY 494
              R RA     E V        +S  ++ +PK K  +   E       +Y      + + 
Sbjct: 1127 --RIRAKQNQQENVK---FILTESDTVKRRPKAKEREAGPEPPPP-LSVYHNGTGTVRRR 1180

Query: 495  VIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP--PASLYHGYLPEN 552
                 +  PEL   P P    P+   +    P     A R PA+ P  P  +    +P+ 
Sbjct: 1181 PASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEA-RKPAKPPVSPKPVLTQPVPK- 1238

Query: 553  GVLRPEPT---KQPPYQLRPSLFVLSPIKEPAKVSPRAASP-AKPSSLDLVPNLPKGALP 608
              L+  PT   K+ P     S  V      P  VSP+   P   P  +  V  LP G+  
Sbjct: 1239 --LQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAG 1296

Query: 609  PSPALPRPSRSSPGLYTSP--GQDSLQPTAVSPPYGGDIS---PVSPSRAWSPRAKQAPR 663
            PSPA P P+R  P     P     SL  +   PP  G  +   P  P RA +  A  A  
Sbjct: 1297 PSPA-PSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAA 1355

Query: 664  P 664
            P
Sbjct: 1356 P 1356



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 51/192 (26%), Positives = 64/192 (33%), Gaps = 40/192 (20%)

Query: 434  PAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEK 493
            P P   A   A   V P+       P++Q  P P   +      G G+    R       
Sbjct: 1212 PPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKK--VPLPGPGSPEVKRAHGTPPP 1269

Query: 494  YVIESSSHTPELARCPSPTMS---LPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLP 550
                 S   P     P P  +   LPS    P+ AP        SPAR PPA+L      
Sbjct: 1270 V----SPKPPPPPTAPKPVKAVAGLPSGSAGPSPAP--------SPARQPPAAL------ 1311

Query: 551  ENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPS 610
                   +P   PP          SP K P+  +P    PAKP            A PP+
Sbjct: 1312 ------AKPPGTPPS------LGASPAKPPSPGAPALHVPAKPPRA-AAAAAAAAAAPPA 1358

Query: 611  PALPRPSRSSPG 622
            P    P  +SPG
Sbjct: 1359 P----PEGASPG 1366



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 42/147 (28%), Positives = 53/147 (36%), Gaps = 28/147 (19%)

Query: 536  PARTPPASLYHGYLPENGVLRPEPTKQ-----------PPYQLRPS-LFVLSPIKEPAKV 583
            P   PP S+YH      G +R  P  +           PP +  P+ L  L P+  P   
Sbjct: 1161 PEPPPPLSVYHN---GTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGE 1217

Query: 584  SPRAASPA---KPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPP 640
            + + A P    KP     VP L     P S  +P P   SP +  + G     P  VSP 
Sbjct: 1218 ARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEVKRAHG----TPPPVSP- 1272

Query: 641  YGGDISPVSPSRAWSPRAKQAPRPSFS 667
                  P  P  A  P    A  PS S
Sbjct: 1273 -----KPPPPPTAPKPVKAVAGLPSGS 1294



 Score = 30.0 bits (66), Expect = 7.4
 Identities = 51/226 (22%), Positives = 88/226 (38%), Gaps = 37/226 (16%)

Query: 250  GTSQMERSPMLERRHFGEKAPAPQP-----------PSLPD---RSPRPQRHIMSRSPMV 295
            GT  + R P  E+    E  P P P           P LP     + +P +  +S  P++
Sbjct: 1173 GTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVL 1232

Query: 296  ER---RMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSS 352
             +   ++ G  +P S++ PL    +P       +  P++   + PP      P + PK  
Sbjct: 1233 TQPVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVSP--KPPP------PPTAPKPV 1284

Query: 353  HLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQG 412
                +AV    +G    S A   +R+      + P   P+      +  +  K       
Sbjct: 1285 ----KAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPS------LGASPAKPPSPGAP 1334

Query: 413  EVGVEEEP-FALGAEASNFQQEPAPRDRASPA-AAEEVVPEWASCL 456
             + V  +P  A  A A+     PAP + ASP  +A + + E ++CL
Sbjct: 1335 ALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACL 1380


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 59/309 (19%), Positives = 113/309 (36%), Gaps = 18/309 (5%)

Query: 32   ENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNP 91
            E + LLT+  + ++     + S+ +  P + +SP     +  +SP+    T    S+++ 
Sbjct: 803  EGSPLLTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTYSE 862

Query: 92   PATDVNQNPPATVVPQSLPLSSIQQNSSEAQLP-SNGTGPASKPSTLCADGQPQAPAEEV 150
              T +   P +T +  +  +S++     +   P +N T   S P+T      P +   E 
Sbjct: 863  GRTPLTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPGEG 922

Query: 151  RCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMS 210
                  +   +TP  ++   +  AT + +S P  +   ++S     +  ++  S   E  
Sbjct: 923  STPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSE-- 980

Query: 211  GRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAP 270
                 TTP    + V  TL         +  P     P  TS    SP           P
Sbjct: 981  ----GTTPL-TSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSP----------PP 1025

Query: 271  APQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPL 330
              +  S+P  +P      ++R P+    +    +      P    T   TY++  S++  
Sbjct: 1026 TAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTT 1085

Query: 331  ASWVRSPPS 339
            A     P S
Sbjct: 1086 ADGTSMPTS 1094



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 77/366 (21%), Positives = 129/366 (35%), Gaps = 31/366 (8%)

Query: 17  VASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSP----------- 65
           VAS E      + +     + TA+    S       S     P+E  +P           
Sbjct: 405 VASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPV 464

Query: 66  AADVNQNLASP---SATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQ 122
           A+    NL++    S T  T ++ +S +PP  +VN  P +T    S PL+S+    S + 
Sbjct: 465 ASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSM----SVST 520

Query: 123 LPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIP-SSR 181
           +P   +  ++  +T      P   + E   S+   +  S P +T S  S   T +P S+R
Sbjct: 521 MPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMPVSTR 580

Query: 182 PPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAA---TTPTKVYSEVHFTLAKPPSVVNR 238
              S   S++       NT V ++ +  S    A   + PT  YSE   T+    SV   
Sbjct: 581 LVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITS-MSVSTT 639

Query: 239 TARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERR 298
                       T     +P+         +   +  S+P  +       ++  P+    
Sbjct: 640 LVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTL 699

Query: 299 MMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQA 358
           +    +      P+   T   T TE  S+   A             P+S P        +
Sbjct: 700 VASSEASTLSTTPVDTSTPVTTSTEASSSPTTAD--------GASMPTSTPSEGSTPLTS 751

Query: 359 VPASKT 364
           +P SKT
Sbjct: 752 MPVSKT 757



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 63/309 (20%), Positives = 109/309 (35%), Gaps = 18/309 (5%)

Query: 32   ENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNP 91
            E + LLT+  L  +     + S+ +  P + +SP     +  +SP  T  T    S+++ 
Sbjct: 2099 EGSPLLTSIPLSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQTSTYSD 2158

Query: 92   PATDVNQNPPATVVPQSLPLSSIQQNSSEAQLP-SNGTGPASKPSTLCADGQPQAPAEEV 150
              T +   P +T V  S  +S++     +   P +N T   S P+T      P +   E 
Sbjct: 2159 RRTPLTSMPVSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPSEG 2218

Query: 151  RCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMS 210
                  +   + P  T+   +  AT + +S P  +   ++S     +  ++  S   E  
Sbjct: 2219 STPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLSE-- 2276

Query: 211  GRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAP 270
                 TTP       H TL     V   +  P     P  TS    SP           P
Sbjct: 2277 ----GTTPLTSIPVSH-TLVANSEVSTLSTTPVDSNTPFTTSTEASSP----------PP 2321

Query: 271  APQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPL 330
              +  S+P  +       ++R P+    +    +      P    T   TY++  S+   
Sbjct: 2322 TAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTSTPVTTYSQAGSSPTT 2381

Query: 331  ASWVRSPPS 339
            A     P S
Sbjct: 2382 ADDTSMPTS 2390



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 80/342 (23%), Positives = 124/342 (36%), Gaps = 37/342 (10%)

Query: 2    EGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAE 61
            EG +   S+      V S E        +  +  + T+     S       S P   P+E
Sbjct: 921  EGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSE 980

Query: 62   VHSP--AADVNQNLASPSATLTTPTSNSSHNPPATDVNQ--NPPATVVPQSLPLSSIQQN 117
              +P  +  V+  L + S   T  T+    N P T   +  +PP T    S+P S+    
Sbjct: 981  GTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTST---- 1036

Query: 118  SSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLI 177
                  PS G+ P ++   +       A +E    ST   D  STP TT S  S  +T  
Sbjct: 1037 ------PSEGSTPLTR---MPVSTTMVASSETSTLSTTPAD-TSTPVTTYSQASSSSTTA 1086

Query: 178  PSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVN 237
              +  P S +   S  +   P    VS    +S  A+  + T V + +  T +   S   
Sbjct: 1087 DGTSMPTSTYSEGSTPLTSVP----VSTRLVVSSEASTLSTTPVDTSIPVTTSTEASSSP 1142

Query: 238  RTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVER 297
             TA   G   P        +P+         A  P   +L   S   + + +S +P+  +
Sbjct: 1143 TTAE--GTSIPTSPPSEGTTPL---------ASMPVSTTLVVSS---EANTLSTTPVDSK 1188

Query: 298  RMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASW-VRSPP 338
              +   + AS   P    T+ PT T    + PL S  VR  P
Sbjct: 1189 TQVATSTEASSPPPTAEVTSMPTSTPGERSTPLTSMPVRHTP 1230



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 73/348 (20%), Positives = 121/348 (34%), Gaps = 28/348 (8%)

Query: 5    SEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHS 64
            S EAS L         +   P+    + +++  TA G  +  +  ++ S+P        +
Sbjct: 3001 SSEASTLSR----TPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIPVSTT 3056

Query: 65   PAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLP 124
            P A     +   S   TTP  ++S    +T+V+ +P       S+P+S+     SE   P
Sbjct: 3057 PVA-----IPEASTLSTTPVDSNSPVVTSTEVSSSP-TPAEGTSMPISTY----SEGSTP 3106

Query: 125  SNGTGPASKPSTLCA----------DGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREA 174
              G   ++ P T  A             P   + E   S    +  S P +T S  S   
Sbjct: 3107 LTGVPVSTTPVTSSAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPL 3166

Query: 175  TLIPSSRPPASDFMSSSL-LIDIQPNTLVVSADQEMSGRAAATT--PTKVYSEVHFTLAK 231
            T +P S         S+L    +  +T V ++ +  S   A  T  PT   SE    L  
Sbjct: 3167 TYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTS 3226

Query: 232  PPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSR 291
             P V N             T     +P+          P  +  S+P  +P      ++ 
Sbjct: 3227 VP-VSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTS 3285

Query: 292  SPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPS 339
             P+    +    +      P    T   TY++  S+ P+A     P S
Sbjct: 3286 MPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTS 3333



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 85/388 (21%), Positives = 142/388 (36%), Gaps = 61/388 (15%)

Query: 5    SEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHS 64
            S EAS L         +  +P+    + +++  TA G           S P  PP+E  +
Sbjct: 1115 SSEASTL----STTPVDTSIPVTTSTEASSSPTTAEGT----------SIPTSPPSEGTT 1160

Query: 65   PAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLP 124
            P       LAS   + T   S+ ++    T V+     T V  S   SS    +    +P
Sbjct: 1161 P-------LASMPVSTTLVVSSEANTLSTTPVDSK---TQVATSTEASSPPPTAEVTSMP 1210

Query: 125  SNGTGPASKPST-LCADGQPQAPAEEVRCSTLLIDKVSTPATTTS-TFSREATLIPSSRP 182
            ++  G  S P T +     P A +E    ST  +D  STP TT++ T S   T   +S P
Sbjct: 1211 TSTPGERSTPLTSMPVRHTPVASSEASTLSTSPVD-TSTPVTTSAETSSSPTTAEGTSLP 1269

Query: 183  PASDFMSSSLLIDIQPNTLVVSADQ-------------------EMSG----RAAATTPT 219
             ++    S+LL  I  +T +V++ +                   E+S         + PT
Sbjct: 1270 TSTTSEGSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPT 1329

Query: 220  KVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERS-PMLERRHFGEKAPAPQPPSLP 278
              YSE    L   P  VN T       +   T+ ++ S P+             +  S+P
Sbjct: 1330 STYSEGRTPLTSIP--VNTTLVASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMP 1387

Query: 279  DRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPP 338
            + +P      ++  P+    ++   +      P+   T   T  E  S+   A       
Sbjct: 1388 NSNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAE------ 1441

Query: 339  SYSVLYPSSDPKSSHLKGQAVPASKTGI 366
               +  P+S P       +++P S T +
Sbjct: 1442 --GISIPTSTPSEGKTPLKSIPVSNTPV 1467



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 81/341 (23%), Positives = 132/341 (38%), Gaps = 39/341 (11%)

Query: 38   TANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVN 97
            T+   H S       S P   P+E  +P   +      P +T+   +S  S    AT V+
Sbjct: 3138 TSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYM------PVSTMLVVSSEDS-TLSATPVD 3190

Query: 98   QNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLI 157
             + P T   ++   ++ +  S     PS G  P +   ++     P A +E    ST  +
Sbjct: 3191 TSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLT---SVPVSNTPVASSEASILSTTPV 3247

Query: 158  DKVSTPATTTSTFS-----REATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGR 212
            D  +TP TT++  S      E T +P+S P       +S+   +   T+  S    +S  
Sbjct: 3248 DS-NTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSM--PVSTTTVASSETSTLSTT 3304

Query: 213  AAAT-TPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPA 271
             A T TP   YS+     +  P + + T+ P    + G T     S         E +  
Sbjct: 3305 PADTSTPVTTYSQA----SSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTL 3360

Query: 272  PQPPSLPDRSPRPQRHIMSRSP-MVERRMMGQRSPASERRPLGNF---TAPPTYTE--TL 325
               P +   +P       S SP   E   +   SP+    PL +    T P   +E  TL
Sbjct: 3361 STTP-VDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTL 3419

Query: 326  STAPLASWVRSPPSYSVLYPSSDPKSSH--LKGQAVPASKT 364
            ST P+        S +++  S++  SS    +G ++P S T
Sbjct: 3420 STTPV-------DSNTLVTTSTEASSSPTIAEGTSLPTSTT 3453



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 84/358 (23%), Positives = 128/358 (35%), Gaps = 23/358 (6%)

Query: 21   EEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSP---AADVNQNLASPS 77
            E   PL   L     L  +    LS       S+P    AE  S    A   +  +++PS
Sbjct: 2689 ERSTPLTNILVSTTLLANSEASTLSTT-PVDTSTPVTTSAEASSSPTTAEGTSMRISTPS 2747

Query: 78   ATLTTPTSNS-SHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPS- 135
               T  TS   S  P A+        T V  S+P+++  + SS        + P S PS 
Sbjct: 2748 DGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSE 2807

Query: 136  ------TLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMS 189
                  ++  +  P A +E    ST  +D  STP TT++  S   T       P S    
Sbjct: 2808 TSTPLTSMPVNHTPVASSEAGTLSTTPVD-TSTPVTTSTKASSSPTTAEGIVVPISTASE 2866

Query: 190  SSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPG 249
             S L+   P +    A  E S  +     T +        +  P+    T+ P  I  P 
Sbjct: 2867 GSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMP--ISTPS 2924

Query: 250  GTSQMERSPMLERRHF-GEKAPAPQPPSLPDRSPRPQRHIMSRSP-MVERRMMGQRSPAS 307
              S    S ++      G +A       +  R+P       S SP   E   M   +P  
Sbjct: 2925 EVSTPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGE 2984

Query: 308  ERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSH---LKGQAVPAS 362
             R PL   T+    T  ++++  ++  R+P   S    +S   SS     +G  +P S
Sbjct: 2985 RRTPL---TSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIPIS 3039



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 82/370 (22%), Positives = 140/370 (37%), Gaps = 36/370 (9%)

Query: 21   EEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATL 80
            E+ V  +    E + LLT+  +  +     + S+ +  P + +SP     +  +S ++  
Sbjct: 2501 EDIVVPISTASEGSTLLTSIPVSTTPVASPEASTLSTTPVDSNSPVVTSTEISSSATSAE 2560

Query: 81   TTPTSNSSHNPPATDVNQNP--------------PATVVPQSLPLSSIQQNSSEAQLPSN 126
             T    S+++  +T +   P                T V  S+P+++  + SS      +
Sbjct: 2561 GTSMPTSTYSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKD 2620

Query: 127  GTGPASKPS-------TLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPS 179
             + P S PS       ++     P A +E    ST  +D  +   T+T T S   T   S
Sbjct: 2621 TSMPISTPSEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGS 2680

Query: 180  SRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRT 239
            S P ++    S+ L +I  +T ++ A+ E S    +TTP    + V  +     S     
Sbjct: 2681 SMPTSTPGERSTPLTNILVSTTLL-ANSEAS--TLSTTPVDTSTPVTTSAEASSSPTTAE 2737

Query: 240  ARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRS-PRPQRHIMSRSP-MVER 297
                 I  P   S    S ++          +    +  D S P       S SP   E 
Sbjct: 2738 GTSMRISTPSDGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSSPTTAEV 2797

Query: 298  RMMGQRSPASERRPLGNFT---APPTYTE--TLSTAPLASWVRSPPSYSVLYPSSDPKSS 352
              M   +P+    PL +      P   +E  TLST P+ +   S P  +    SS P ++
Sbjct: 2798 TSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDT---STPVTTSTKASSSPTTA 2854

Query: 353  HLKGQAVPAS 362
              +G  VP S
Sbjct: 2855 --EGIVVPIS 2862



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 68/327 (20%), Positives = 123/327 (37%), Gaps = 14/327 (4%)

Query: 29  YLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSS 88
           +++  +A  TA G   +   E +         E+ S  + V  +    S+T  TPT + +
Sbjct: 58  HVRTGSAANTATGTTSTNVVEPRMYLSCSTNPEMTSIESSVTSDTPGVSSTRMTPTESRT 117

Query: 89  HNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAE 148
            +   +D       T+ P S   +S         +P +     S  ST+        P+ 
Sbjct: 118 TSESTSD-----STTLFPSSTEDTSSPTTPEGTDVPMSTPSEESISSTMAFVSTAPLPSF 172

Query: 149 EVRCSTLLIDKVSTPATTTSTFSREATLIPSSR-PPASDFMSSSLLIDIQPNTLVVSADQ 207
           E   S      +STP TT++  S   T   S+  P +++   S+ L  +  +T+ V++ +
Sbjct: 173 EAYTSLTYKVDMSTPLTTSTQASSSPTTPESTTIPKSTNSEGSTPLTSMPASTMKVASSE 232

Query: 208 EMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAP-GGTSQMERSPMLERRHFG 266
            ++     TTP ++ + V  +     S            AP GG++ + R P+       
Sbjct: 233 AIT---LLTTPVEISTPVTISAQASSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVS 289

Query: 267 EKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASE-RRPLGNFTAPPTYTETL 325
            +A            P       S SP          S  +E   PL   T+ P  T  +
Sbjct: 290 SEASTLSTTPAATNIPVITSTEASSSPTTAEGTSIPTSTYTEGSTPL---TSTPASTMPV 346

Query: 326 STAPLASWVRSPPSYSVLYPSSDPKSS 352
           +T+ +++   +P   S L  +S   SS
Sbjct: 347 ATSEMSTLSITPVDTSTLVTTSTEPSS 373



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 88/420 (20%), Positives = 159/420 (37%), Gaps = 55/420 (13%)

Query: 5    SEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSP--APPPAEV 62
            S EAS L         +   P+    + + +  TA G  +  +  ++ ++P  + P +  
Sbjct: 3354 SSEASTL----STTPVDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEGTTPLASMPVSTT 3409

Query: 63   HSPAADVNQNLASP--SATLTTPTSNSSHNPPATDVNQNPPATVVPQS-----LPLSSIQ 115
               +++VN    +P  S TL T ++ +S +P   +    P +T    S     +PLS+  
Sbjct: 3410 PVVSSEVNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTP 3469

Query: 116  QNSSEAQL----------PSNGTGPA-SKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPA 164
              SSEA            P   + P  S P+T      P + A E   ST L    + P 
Sbjct: 3470 VASSEASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGE--GSTPL---TNMPV 3524

Query: 165  TTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSE 224
            +TT   S EA+ + ++   ++ F++SS      P TL V+           +TP++  S 
Sbjct: 3525 STTPVASSEASTLSTTPVDSNTFVTSSSQASSSPATLQVTT-------MRMSTPSEGSSS 3577

Query: 225  VHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRP 284
            +   L     V +  A       P   S    +P+            P+  +LP  +P  
Sbjct: 3578 LTTMLLSSTYVTSSEA-----STPSTPSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSE 3632

Query: 285  QRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTET-LSTAPLASWVRSPPSYSVL 343
                ++  P+    +    +  +   P+   T+ P  T T +S++P+     + P ++  
Sbjct: 3633 VSTPLTIMPVSTTSVTISEAGTASTLPVD--TSTPVITSTQVSSSPVTPEGTTMPIWT-- 3688

Query: 344  YPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTAD 403
                 P         +P S T +     +  GS  S  + V    VT + + +    T D
Sbjct: 3689 -----PSEGSTPLTTMPVSTTRV----TSSEGSTLSTPSVVTSTPVTTSTEAISSSATLD 3739



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 69/334 (20%), Positives = 122/334 (36%), Gaps = 17/334 (5%)

Query: 39  ANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQ 98
           +N    + +  +  S+ A   +   S  ++    + S S + T   S+ +     T V+ 
Sbjct: 597 SNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLSTTPVDS 656

Query: 99  NPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPST-LCADGQPQAPAEEVRCSTLLI 157
           N P T   ++   S+  + +S   +P++     S P T +  +    A +E    ST  +
Sbjct: 657 NTPVTTSTEATSSSTTAEGTS---MPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTTPV 713

Query: 158 DKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATT 217
           D  STP TT++  S   T    +  P S     S  +   P +  +    E S  +    
Sbjct: 714 D-TSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPL 772

Query: 218 PTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSL 277
            T  +       +  P+    T+ P    +  G+  +   P+        +A       +
Sbjct: 773 DTSTHITTSTEASCSPTTTEGTSMPISTPSE-GSPLLTSIPVSITPVTSPEASTLSTTPV 831

Query: 278 PDRSPRPQRHIMSRSPM-VERRMMGQRSPASERRPLGNFTAPPTYT-----ETLSTAPLA 331
              SP      +S SP   E   M   + +  R PL +     T        TLST P+ 
Sbjct: 832 DSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRTPLTSMPVSTTLVATSAISTLSTTPVD 891

Query: 332 SWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTG 365
           +   S P  +     S P +S  +G ++P S  G
Sbjct: 892 T---STPVTNSTEARSSPTTS--EGTSMPTSTPG 920



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 78/386 (20%), Positives = 138/386 (35%), Gaps = 40/386 (10%)

Query: 17   VASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAAD--VNQNLA 74
            V S E    L   +     ++T+N +  S       S P    +E  +P     VN  L 
Sbjct: 1290 VTSPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTPLTSIPVNTTLV 1349

Query: 75   SPSATL---TTPTSNSSHNPPATDV-------------NQNPPATVVP-QSLPLSSIQQN 117
            + SA     TTP  NS+    +T+              N NP     P  S+P+S+    
Sbjct: 1350 ASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLTSIPVSTTPVV 1409

Query: 118  SSEAQLPSNGTGPASKPSTLCADGQ-----------PQAPAEEVRCSTLLIDKVSTPATT 166
            SSEA   S      S P T  A+             P +   E +     I   +TP   
Sbjct: 1410 SSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLKSIPVSNTPVAN 1469

Query: 167  TSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAA---TTPTKVYS 223
            +   +   T + S+ P  +    SS     +  ++ +S   E S    +   +T T   S
Sbjct: 1470 SEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIAISTPSEGSTALTSIPVSTTTVASS 1529

Query: 224  EVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPR 283
            E++ +L+  P+V +     +  QA    +  + + M    +     P    P        
Sbjct: 1530 EIN-SLSTTPAVTSTPVTTYS-QASSSPTTADGTSMQTSTYSEGSTPLTSLPVSTMLVVS 1587

Query: 284  PQRHIMSRSPMVERRMMGQRSPASERRPLG----NFTAPPTYTETLSTAPLASW-VRSPP 338
             + + +S +P+  +  +   + AS            + P   +  L++ P+++  V SP 
Sbjct: 1588 SEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVASPE 1647

Query: 339  SYSVLYPSSDPKSSHLKGQAVPASKT 364
            + ++     D  S  +    V +S T
Sbjct: 1648 ASTLSTTPVDSNSPVITSTEVSSSPT 1673



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 76/352 (21%), Positives = 130/352 (36%), Gaps = 40/352 (11%)

Query: 21   EEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATL 80
            +   P+    +  ++  TA G  +  +  ++ ++P       H+  A+     +  S   
Sbjct: 2246 DTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTLVAN-----SEVSTLS 2300

Query: 81   TTPTSNSSHNPPATDVNQNPPATVVPQSLPLS-SIQQNSSEAQLPSNGTGPAS-KPSTLC 138
            TTP  +++    +T+ + +PP T    S+P S S + N+   ++P + T  AS + STL 
Sbjct: 2301 TTPVDSNTPFTTSTEAS-SPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLS 2359

Query: 139  ADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQP 198
                   PA+            STP TT S      T    +  P S +   S  +   P
Sbjct: 2360 T-----TPAD-----------TSTPVTTYSQAGSSPTTADDTSMPTSTYSEGSTPLTSVP 2403

Query: 199  NTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSP 258
             + +     E S  +     T          +  P+    T+ P    +  GT+ +   P
Sbjct: 2404 VSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSE-GTTPLASMP 2462

Query: 259  MLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAP 318
            +        +A       +   +P       S SP     ++   S ASE   L   T+ 
Sbjct: 2463 VSTTPVVSSEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTL--LTSI 2520

Query: 319  PTYT--------ETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPAS 362
            P  T         TLST P+ S   SP   S    SS   ++  +G ++P S
Sbjct: 2521 PVSTTPVASPEASTLSTTPVDS--NSPVVTSTEISSS---ATSAEGTSMPTS 2567



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 75/335 (22%), Positives = 125/335 (37%), Gaps = 47/335 (14%)

Query: 32   ENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNP 91
            E + LLT+  +  +     + S+ +  P + +SP     +  +SP     TP   +S   
Sbjct: 1628 EGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSP-----TPAEGTS--- 1679

Query: 92   PATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVR 151
                    P +T      PL+SI   ++    P   +  ++  +T   +  P   + E R
Sbjct: 1680 -------MPTSTYTEGRTPLTSITVRTT----PVASSAISTLSTTPVDNSTPVTTSTEAR 1728

Query: 152  CSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSL-LIDIQPNTLVVSADQEMS 210
             S    +  S P +T S  +   T IP S  P     +S+L    I  +T V ++ +  S
Sbjct: 1729 SSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVTTSTEATS 1788

Query: 211  GRAAA---TTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGE 267
                A   + PT   SE    L   P  V+ T     + A    S +  +P+        
Sbjct: 1789 SPTTAEGTSIPTSTLSEGMTPLTSTP--VSHT-----LVANSEASTLSTTPV------DS 1835

Query: 268  KAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLST 327
             +P     ++   SP P     +    +      + S A    P+   T   + T TLST
Sbjct: 1836 NSPVVTSTAV-SSSPTP-----AEGTSIATSTPSEGSTALTSIPVSTTTVASSETNTLST 1889

Query: 328  APLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPAS 362
             P    V S P  +    SS P ++   G ++P S
Sbjct: 1890 TPA---VTSTPVTTYAQVSSSPTTA--DGSSMPTS 1919



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 81/370 (21%), Positives = 136/370 (36%), Gaps = 59/370 (15%)

Query: 32   ENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNP 91
            E +  LT+  +  +    ++ ++ +  PA   +P     Q  +SP+      T++ S  P
Sbjct: 1864 EGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPT------TADGSSMP 1917

Query: 92   PATDVNQNPPATVVP------QSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADG---- 141
             +T     PP T +P       S  ++++    ++ + P      AS   T  ADG    
Sbjct: 1918 TSTPREGRPPLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPT-TADGTSMP 1976

Query: 142  -----QPQAPAEEVRCSTLLIDK------------VSTPATTTSTFSRE-----ATLIPS 179
                 +   P   +  ST L+               STPATT++  S        T I +
Sbjct: 1977 TPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSSPTTAGGTSIQT 2036

Query: 180  SRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRT 239
            S P       + + +     TLVVS++    G   +TTP    ++V     +  S     
Sbjct: 2037 STPSERTTPLAGMPVS---TTLVVSSE----GNTLSTTPVDSKTQV-TNSTEASSSATAE 2088

Query: 240  ARPFGIQAPG-GTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERR 298
                 I AP  G+  +   P+        +A       +   SP      +S SP+    
Sbjct: 2089 GSSMTISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEG 2148

Query: 299  MMGQRSPASERR------PLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSS 352
               Q S  S+RR      P+       +   TLST P+ +   S P  +     S P +S
Sbjct: 2149 TSMQTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTPVDT---STPVTNSTEARSSPTTS 2205

Query: 353  HLKGQAVPAS 362
              +G ++P S
Sbjct: 2206 --EGTSMPTS 2213



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 55/227 (24%), Positives = 87/227 (38%), Gaps = 44/227 (19%)

Query: 51   QQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATV------ 104
            + S+ +  PA+  +P    +Q  +SP+    T    S+++  +T +   P +T+      
Sbjct: 2354 ETSTLSTTPADTSTPVTTYSQAGSSPTTADDTSMPTSTYSEGSTPLTSVPVSTMPVVSSE 2413

Query: 105  --------VPQSLPLSSIQQNSSE----------AQLPSNGTGP-ASKP----------- 134
                    V  S P+++  + SS              PS GT P AS P           
Sbjct: 2414 ASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEA 2473

Query: 135  ---STLCAD-GQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIP-SSRPPASDFMS 189
               ST   D   P   + E   S    + +  P +T S  S   T IP S+ P AS   S
Sbjct: 2474 GTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPEAS 2533

Query: 190  SSLLIDIQPNTLVVSADQEMSGRAAA---TTPTKVYSEVHFTLAKPP 233
            +     +  N+ VV++ +  S   +A   + PT  YSE    L   P
Sbjct: 2534 TLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMP 2580



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 58/245 (23%), Positives = 97/245 (39%), Gaps = 30/245 (12%)

Query: 32   ENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSAT--LTTPTSN-SS 88
            E +  LT+  +  +    ++ S+ +  PA+  +P    +Q  +SP      + PTS  S 
Sbjct: 3278 EGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSE 3337

Query: 89   HNPPATDVNQNPPATVVPQSLPLSSIQ-------QNSSEAQL-PSNGTG---PASKPS-- 135
             + P T+++ +    V  ++  LS+           S+EA L P+   G   P S PS  
Sbjct: 3338 GSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEG 3397

Query: 136  -----TLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSS 190
                 ++     P   +E    ST  +D  +T  TT++  S   T+   +  P S     
Sbjct: 3398 TTPLASMPVSTTPVVSSEVNTLSTTPVDS-NTLVTTSTEASSSPTIAEGTSLPTSTTSEG 3456

Query: 191  SLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKP----PSVVNRTARPFGIQ 246
            S  + I P +    A  E S    +TTP    + V  T + P    P+    T+ P    
Sbjct: 3457 STPLSIMPLSTTPVASSEAS--TLSTTPVDTSTPV--TTSSPTNSSPTTAEVTSMPTSTA 3512

Query: 247  APGGT 251
              G T
Sbjct: 3513 GEGST 3517



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 72/350 (20%), Positives = 134/350 (38%), Gaps = 48/350 (13%)

Query: 30   LKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSH 89
            L E    LT+  +  +    ++ S+ +  P + +SP        +SP+    T  + S+ 
Sbjct: 1803 LSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIATSTP 1862

Query: 90   NPPATDVNQNPPATVVPQSLPLSSIQQN--------SSEAQLPSNGT--GPASKPSTLCA 139
            +  +T +   P +T    S   +++           ++ AQ+ S+ T    +S P++   
Sbjct: 1863 SEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPTTADGSSMPTSTPR 1922

Query: 140  DGQPQAPAEEVRCSTLLIDKVS----------TPATTTSTFSREATLIPSSRPPASDFMS 189
            +G+P   +  V  +T+   +++          TP TT S  S   T    +  P   +  
Sbjct: 1923 EGRPPLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADGTSMPTPAYSE 1982

Query: 190  SSLLIDIQP--NTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQA 247
             S  +   P   TLVVS++      A+  + T V +    T +   S    TA       
Sbjct: 1983 GSTPLTSMPLSTTLVVSSE------ASTLSTTPVDTSTPATTSTEGSSSPTTA------- 2029

Query: 248  PGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPAS 307
             GGTS    +P  ER       P    P         + + +S +P+  +  +   + AS
Sbjct: 2030 -GGTSIQTSTPS-ER-----TTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEAS 2082

Query: 308  ERRPLG----NFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSH 353
                        +AP   +  L++ PL++   + P  S L  S+ P  S+
Sbjct: 2083 SSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEASTL--STTPVDSN 2130



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 77/365 (21%), Positives = 132/365 (36%), Gaps = 46/365 (12%)

Query: 17   VASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASP 76
            +++  E  PL+  +  +   + +             +SP     EV S      +  + P
Sbjct: 1623 ISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPA-EGTSMP 1681

Query: 77   SATL-------------TTPTSNSSHNP-PATDVNQNPPATVVPQ--SLPLSSIQQNSSE 120
            ++T              TTP ++S+ +    T V+ + P T   +  S P +S +  S  
Sbjct: 1682 TSTYTEGRTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTS-EGTSMP 1740

Query: 121  AQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPAT-----TTSTFSREAT 175
               PS GT P    +++     P   +E    S   ID  STP T     T+S  + E T
Sbjct: 1741 NSTPSEGTTPL---TSIPVSTTPVLSSEASTLSATPID-TSTPVTTSTEATSSPTTAEGT 1796

Query: 176  LIPSS------RPPASDFMSSSLLIDIQPNTL----VVSADQEMSGRAAATTPTKVYSEV 225
             IP+S       P  S  +S +L+ + + +TL    V S    ++  A +++PT      
Sbjct: 1797 SIPTSTLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTS 1856

Query: 226  HFTLAKPPSVVNRTARPFGIQ--APGGTSQMERSPMLERRHFGEKAPAPQPP------SL 277
              T          T+ P      A   T+ +  +P +        A     P      S+
Sbjct: 1857 IATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPTTADGSSM 1916

Query: 278  PDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSP 337
            P  +PR  R  ++  P+    +                T   TY++  S+   A     P
Sbjct: 1917 PTSTPREGRPPLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADGTSMP 1976

Query: 338  -PSYS 341
             P+YS
Sbjct: 1977 TPAYS 1981



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 69/338 (20%), Positives = 117/338 (34%), Gaps = 54/338 (15%)

Query: 50   AQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
            ++ S+ +  P + +SP        +SP+    T  + S+ +  +T +   P +T    S 
Sbjct: 1470 SEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIAISTPSEGSTALTSIPVSTTTVASS 1529

Query: 110  PLSSIQQNSSEAQLPSNGTGPASKPSTLCADG---------QPQAPAEEVRCSTLLIDKV 160
             ++S+    +    P      AS   T  ADG         +   P   +  ST+L+  V
Sbjct: 1530 EINSLSTTPAVTSTPVTTYSQASSSPT-TADGTSMQTSTYSEGSTPLTSLPVSTMLV--V 1586

Query: 161  STPATTTS----------TFSREA-----------------------TLIP-SSRPPASD 186
            S+ A T S          T S EA                       T IP S+ P AS 
Sbjct: 1587 SSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVASP 1646

Query: 187  FMSSSLLIDIQPNTLVVSADQEMSGRAAA---TTPTKVYSEVHFTLAKPPSVVNRT--AR 241
              S+     +  N+ V+++ +  S    A   + PT  Y+E    L    S+  RT    
Sbjct: 1647 EASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYTEGRTPLT---SITVRTTPVA 1703

Query: 242  PFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMG 301
               I     T     +P+             +  S+P+ +P      ++  P+    ++ 
Sbjct: 1704 SSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPVLS 1763

Query: 302  QRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPS 339
              +      P+   T   T TE  S+   A     P S
Sbjct: 1764 SEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTS 1801



 Score = 33.9 bits (76), Expect = 0.51
 Identities = 43/198 (21%), Positives = 76/198 (38%), Gaps = 13/198 (6%)

Query: 58   PPAEVHSPAADV----NQNLASP---SATLTTPTSNSSHNPPATDVNQNPPATVVPQSLP 110
            P   V S  ADV       +++P   S  L TP+++SS    +    +      +  + P
Sbjct: 3942 PSTPVTSSTADVFPATTGAVSTPVITSTELNTPSTSSSSTTTSFSTTKEFTTPAMTTAAP 4001

Query: 111  LSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS-T 169
            L+ +  +++ +   +   G  +  STL A   P               + S P+T TS T
Sbjct: 4002 LTYVTMSTAPSTPRTTSRGCTTSASTLSATSTPHTSTSVTTRPVTPSSESSRPSTITSHT 4061

Query: 170  FSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTL 229
                     SS PP +   +SS  ++ +  T + +  +  +   +  T T      + T+
Sbjct: 4062 IPPTFPPAHSSTPPTTS--ASSTTVNPEAVTTMTTRTKPSTRTTSFPTVTTTAVPTNTTI 4119

Query: 230  AKPPS---VVNRTARPFG 244
               P+    V RT   FG
Sbjct: 4120 KSNPTSTPTVPRTTTCFG 4137


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 73/338 (21%), Positives = 127/338 (37%), Gaps = 37/338 (10%)

Query: 335 RSPPSYSVLYPSSDPKSSHLKGQAVPA-SKTGILEESMAR---RGSRKSMFTFVEKPKVT 390
           +SPP+     P  + KS   +    PA +K+   EE+ +    +   K+     E+ K  
Sbjct: 502 KSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP 561

Query: 391 P---NPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEE 447
           P   +P+  +    A+ K  ++ +     EE      A++    + P   +  SPA A+ 
Sbjct: 562 PEAKSPEKEEAKSPAEVKSPEKAKSPAK-EEAKSPAEAKSPEKAKSPVKEEAKSPAEAKS 620

Query: 448 VVPEWASCLKSPRIQAKPK-PKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELA 506
            V E A      +   K K P   +  S    K  E    +     K  +++ + +PE A
Sbjct: 621 PVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKA 680

Query: 507 RCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQ 566
           + P     + +  K P  A    +  ++SP +           PE      +   + P +
Sbjct: 681 KSP-----VKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEK 735

Query: 567 LRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTS 626
            +      SP+KE AK   +A SP K  +LD+    P+   P       P+   P    S
Sbjct: 736 AK------SPVKEEAKSPEKAKSPEKAKTLDV--KSPEAKTPAKEEARSPADKFPEKAKS 787

Query: 627 PGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRP 664
           P ++ ++               SP +A SP  + A  P
Sbjct: 788 PVKEEVK---------------SPEKAKSPLKEDAKAP 810



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 92/442 (20%), Positives = 158/442 (35%), Gaps = 56/442 (12%)

Query: 246 QAPGGTSQMERSPMLERRHFGEK---APAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQ 302
           +A GG  +  +SP  E     EK   +P  +    P  +  P++   ++SP   +     
Sbjct: 493 EAEGGEEET-KSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKE-EAKSPAEVKSPEKA 550

Query: 303 RSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPAS 362
           +SPA E          P   E  S A     V+SP       P+ +   S  + ++   +
Sbjct: 551 KSPAKEEAKSPPEAKSPEKEEAKSPAE----VKSPEKAKS--PAKEEAKSPAEAKSPEKA 604

Query: 363 KTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFA 422
           K+ + EE+ +   ++  +    + P    +P          EK +   + E    E+   
Sbjct: 605 KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSP----------EKAKSPTKEEAKSPEK--- 651

Query: 423 LGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSP-RIQAKPKPKPNQNLSEASGKGA 481
             A++   ++  +P    SP  AE   PE A   KSP + +AK   K    + E +    
Sbjct: 652 --AKSPEKEEAKSPEKAKSPVKAEAKSPEKA---KSPVKAEAKSPEKAKSPVKEEA---- 702

Query: 482 ELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSP--ART 539
                +     K  ++  + +PE A+ P     +    K P  A    +  ++SP  A++
Sbjct: 703 -----KSPEKAKSPVKEEAKSPEKAKSP-----VKEEAKTPEKAKSPVKEEAKSPEKAKS 752

Query: 540 PP-ASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDL 598
           P  A       PE      E  + P  +        SP+KE  K   +A SP K  +   
Sbjct: 753 PEKAKTLDVKSPEAKTPAKEEARSPADKFPEK--AKSPVKEEVKSPEKAKSPLKEDAKAP 810

Query: 599 VPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRA 658
              +PK     SP           +   P +   +    +P           S+      
Sbjct: 811 EKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATP----KTEEKKDSKKEEAPK 866

Query: 659 KQAPRPSFSTRNAGIEAQVWKP 680
           K+AP+P    +    E  V KP
Sbjct: 867 KEAPKPKVEEKK---EPAVEKP 885



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 106/549 (19%), Positives = 196/549 (35%), Gaps = 73/549 (13%)

Query: 98   QNPPA--TVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTL 155
            ++PPA     P+    S +++   EA+ P+    P  +        + ++PAE       
Sbjct: 502  KSPPAEEAASPEKEAKSPVKE---EAKSPAEAKSPEKE--------EAKSPAE------- 543

Query: 156  LIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAA 215
                V +P    S    EA   P ++ P  +   S   +   P      A +E    A A
Sbjct: 544  ----VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVK-SPEKAKSPAKEEAKSPAEA 598

Query: 216  TTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPP 275
             +P K  S V      P    +         A   + +  +SP  E     EKA +P+  
Sbjct: 599  KSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658

Query: 276  SL--PDRSPRP-----QRHIMSRSPMVERRMMGQ--RSPASERRPLGNFTAPPTYTETLS 326
                P+++  P     +    ++SP+       +  +SP  E          P   E  S
Sbjct: 659  EAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718

Query: 327  ----TAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFT 382
                 +P+    ++P       P  +   S  K ++   +KT  ++   A+  +++   +
Sbjct: 719  PEKAKSPVKEEAKTPE--KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARS 776

Query: 383  FVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRD---R 439
              +K        + + V++ ++ +    +     E+E        S  ++E  P++   +
Sbjct: 777  PADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVK 836

Query: 440  ASPAAAEE----VVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYV 495
              P  AEE      P+      S + +A  K  P   + E      E    ++S++E   
Sbjct: 837  EPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE--KPKESKVE--- 891

Query: 496  IESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFR--VASRSP----ARTP--PASLYHG 547
                    +  + P+P    P+  +   +A    +  VA + P    A+ P  PA     
Sbjct: 892  -AKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA 950

Query: 548  YLPENGVLRPE----PTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLP 603
              PE    + E    P ++P  + +      +  KEP+K  P+A    K SS D      
Sbjct: 951  -APEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSK--PKAEKAEKSSSTD-----Q 1002

Query: 604  KGALPPSPA 612
            K + PP  A
Sbjct: 1003 KDSKPPEKA 1011


>gi|239752594 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 673

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 140/642 (21%), Positives = 223/642 (34%), Gaps = 79/642 (12%)

Query: 57  PPPAEVHSPAADVNQNLASPSATLTTPTSNS--SHNPPATDVNQNPPATVVPQSLPLSSI 114
           PP A +    +  +  ++   A+LT   S+S  +  P    + + PP     ++LP +S+
Sbjct: 53  PPRASLKGTTSMASLMVSPSRASLTRMQSSSLLTRTPSMASLKRMPPRASRTRTLPRASL 112

Query: 115 QQNSSEAQL---PSNG---TGP-----ASKPSTLCADGQP-QAPAEEVRCSTLLIDKVST 162
            +  S A L   PS     T P     +  PST  A   P +A          L    ST
Sbjct: 113 MRRPSTASLTRSPSRASLTTTPSRASLSMTPSTAAALTMPSRASLTRTPPRASLTMTPST 172

Query: 163 PATTTSTFSREATLIPSSRPPASDFMSSSLL-IDIQPNTLVVSADQEMSGRAAATTPTKV 221
            + T +      T +PS   P     ++SL  +D   +     +    +G     +PT  
Sbjct: 173 ASLTRTPPRASPTGMPSRTSPTGMPSTASLTKMDSTASITRTLSRASPTGTPPRASPTGS 232

Query: 222 YSEVHFTLAKPPSVVNRT---ARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLP 278
                 ++    +++ RT   A P G+ +    ++M+ +  + R         P  PS  
Sbjct: 233 PPRASLSMMPSTALLIRTPPRASPTGMLSRTSLTKMDSTASITR--------TPSRPSTA 284

Query: 279 DRSPRPQRHIMSRSPMVE--RRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRS 336
             +  P R  +S +P      RM+ + SP        + T   +      T P AS  R+
Sbjct: 285 SPTGTPSRASLSMTPSTASLMRMLPRASPTG-MLSRTSLTKMDSTASISRTPPRASITRT 343

Query: 337 PPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLL 396
           P   S   P+  P ++   G    AS TG    + +  G   +       P+ +P     
Sbjct: 344 PSRAS---PTGKPSTASPTGTPSRASPTG-SPSTASLTGLSSTASPTGTPPRASPT---- 395

Query: 397 DLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCL 456
               TA   R+       G+      L   +       A   R  P A+    P  AS  
Sbjct: 396 GTPSTASLTRKPPRASPTGM------LSRTSITKMDSTASPTRTPPRASPTGTPPRASPT 449

Query: 457 KSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTM--- 513
            +P      +  P    S AS  G+   A             S     L R PS      
Sbjct: 450 GTP-----SRASPTGTQSTASPTGSPSTASPTGSPSTASPTGSPSRASLTRTPSRASLTK 504

Query: 514 --SLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSL 571
             S  S  + P+ A   +  ++ SP  +P  +L  G  P    L   P++          
Sbjct: 505 MESTASITRTPSRASPTWTPSTASPTGSPSTALAMG-SPSRAALTRTPSR---------- 553

Query: 572 FVLSPIKEPAKVS---PRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSP-GLYTS- 626
              S  + P++ S   P  AS  +  S  L+  +P  A P       PSR+SP G+ +S 
Sbjct: 554 --ASLTRTPSRASLTTPSRASLTRTPSTVLLTRMPPSASPTG----MPSRTSPTGMPSSA 607

Query: 627 --PGQDSLQPTAVSPPYGG--DISPVSPSRAWSPRAKQAPRP 664
                DS      +PP     +  P +      PRA     P
Sbjct: 608 LLTKMDSTASITRTPPRASPTETPPRASPTGTPPRASPTGTP 649



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 126/626 (20%), Positives = 206/626 (32%), Gaps = 98/626 (15%)

Query: 11  LRHLEKVASEEEEVPLVVYLKE-NAALLTAN----GLHLSQNREAQQSSPAPPPAEVHSP 65
           L+ +   AS    +P    ++  + A LT +     L  + +R +   +P+   A     
Sbjct: 94  LKRMPPRASRTRTLPRASLMRRPSTASLTRSPSRASLTTTPSRASLSMTPSTAAALTMPS 153

Query: 66  AADVNQNLASPSATLTTPTSNSSHNPP---ATDVNQNPPATVVPQSLPLSSIQQNSSEAQ 122
            A + +     S T+T  T++ +  PP    T +      T +P +  L+ +   +S  +
Sbjct: 154 RASLTRTPPRASLTMTPSTASLTRTPPRASPTGMPSRTSPTGMPSTASLTKMDSTASITR 213

Query: 123 LPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLI-----------------DKVSTPAT 165
             S  +   + P        P+A    +  + LLI                  K+ + A+
Sbjct: 214 TLSRASPTGTPPRASPTGSPPRASLSMMPSTALLIRTPPRASPTGMLSRTSLTKMDSTAS 273

Query: 166 TTSTFSREATLIPSSRPPASDFM---SSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVY 222
            T T SR +T  P+  P  +      S++ L+ + P           +G  + T+ TK+ 
Sbjct: 274 ITRTPSRPSTASPTGTPSRASLSMTPSTASLMRMLPRA-------SPTGMLSRTSLTKMD 326

Query: 223 SEVHFTLAKPPSVVNRT---ARPFG---IQAPGGT---SQMERSPMLERRH--FGEKAPA 271
           S    +   P + + RT   A P G     +P GT   +    SP            +P 
Sbjct: 327 STASISRTPPRASITRTPSRASPTGKPSTASPTGTPSRASPTGSPSTASLTGLSSTASPT 386

Query: 272 PQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLA 331
             PP            +  + P      M  R+  ++     + T  P       T P A
Sbjct: 387 GTPPRASPTGTPSTASLTRKPPRASPTGMLSRTSITKMDSTASPTRTPPRASPTGTPPRA 446

Query: 332 SWVRSPP------SYSVLYPSSDPKSSHLKGQAVPASKTGI-LEESMARRGSRKSMFTFV 384
           S   +P       + S   P+  P ++   G    AS TG     S+ R  SR S+    
Sbjct: 447 SPTGTPSRASPTGTQSTASPTGSPSTASPTGSPSTASPTGSPSRASLTRTPSRASLTKME 506

Query: 385 EKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRD--RASP 442
               +T  P       T             G      A+G+ +         R     +P
Sbjct: 507 STASITRTPSRASPTWTPS------TASPTGSPSTALAMGSPSRAALTRTPSRASLTRTP 560

Query: 443 AAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHT 502
           + A    P  AS  ++P      +  P+     AS  G              ++     T
Sbjct: 561 SRASLTTPSRASLTRTPSTVLLTRMPPS-----ASPTGMPSRTSPTGMPSSALLTKMDST 615

Query: 503 PELARCP---SPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEP 559
             + R P   SPT + P +   PT  P        SP  TPP              R  P
Sbjct: 616 ASITRTPPRASPTETPPRA--SPTGTP-----PRASPTGTPP--------------RASP 654

Query: 560 TKQPPYQLRPSLFVLSPIKEPAKVSP 585
           T  PP          SP   P++ SP
Sbjct: 655 TGTPPR--------ASPTGTPSRASP 672



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 132/570 (23%), Positives = 193/570 (33%), Gaps = 78/570 (13%)

Query: 130 PASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMS 189
           P   PST    G P   +     ST  +    + A+ T T  R +    +S        S
Sbjct: 13  PTRTPSTASLTGTPSRASLTGTPSTASLMGTPSRASLTGTPPRASLKGTTSMASLMVSPS 72

Query: 190 SSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPG 249
            + L  +Q ++L+       S +      ++  +    +L + PS  + T  P       
Sbjct: 73  RASLTRMQSSSLLTRTPSMASLKRMPPRASRTRTLPRASLMRRPSTASLTRSP---SRAS 129

Query: 250 GTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPR------PQRHIMSRSP--MVERRMMG 301
            T+   R+ +            P   SL    PR      P    ++R+P       M  
Sbjct: 130 LTTTPSRASLSMTPSTAAALTMPSRASLTRTPPRASLTMTPSTASLTRTPPRASPTGMPS 189

Query: 302 QRSPAS--ERRPLGNFTAPPTYTETLS------TAPLASWVRSPPSYSVLYPSSDPKSSH 353
           + SP        L    +  + T TLS      T P AS   SPP  S+   S  P ++ 
Sbjct: 190 RTSPTGMPSTASLTKMDSTASITRTLSRASPTGTPPRASPTGSPPRASL---SMMPSTAL 246

Query: 354 LKGQAVPASKTGILEE-SMARRGSRKSMFTFVEKPKV---TPNPDLLDLVQTADEKRRQR 409
           L      AS TG+L   S+ +  S  S+     +P     T  P    L  T       R
Sbjct: 247 LIRTPPRASPTGMLSRTSLTKMDSTASITRTPSRPSTASPTGTPSRASLSMTPSTASLMR 306

Query: 410 DQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKP 469
                        L   +           +    A+    P  AS  ++P  +A P  KP
Sbjct: 307 ------------MLPRASPTGMLSRTSLTKMDSTASISRTPPRASITRTPS-RASPTGKP 353

Query: 470 NQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAF 529
               S AS  G        SR       S++    L+   SPT + P +   PT  P   
Sbjct: 354 ----STASPTGT------PSRASPTGSPSTASLTGLSSTASPTGTPPRA--SPTGTP--- 398

Query: 530 RVASRSPARTPPASLYHGYLPENGVLRPE----PTKQPPYQLRPSLFVLSPIKEPAKVSP 585
             ++ S  R PP +   G L    + + +    PT+ PP          SP   P + SP
Sbjct: 399 --STASLTRKPPRASPTGMLSRTSITKMDSTASPTRTPPR--------ASPTGTPPRASP 448

Query: 586 RA----ASPAKPSSLDLVPNLPKGALP---PSPALPRPSRSSPGLYTSPGQDSLQPTAVS 638
                 ASP    S       P  A P   PS A P  S S   L  +P + SL  T + 
Sbjct: 449 TGTPSRASPTGTQSTASPTGSPSTASPTGSPSTASPTGSPSRASLTRTPSRASL--TKME 506

Query: 639 PPYGGDISPVSPSRAWSPRAKQAPRPSFST 668
                  +P   S  W+P +  +P  S ST
Sbjct: 507 STASITRTPSRASPTWTP-STASPTGSPST 535



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 109/475 (22%), Positives = 163/475 (34%), Gaps = 75/475 (15%)

Query: 246 QAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSP 305
           + P   S     P   R     +A   + PS    +  P R  ++ +P      M   + 
Sbjct: 87  RTPSMASLKRMPPRASRTRTLPRASLMRRPSTASLTRSPSRASLTTTPSRASLSMTPSTA 146

Query: 306 ASERRPL-GNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKT 364
           A+   P   + T  P       T   AS  R+PP  S   P+  P  +   G    AS T
Sbjct: 147 AALTMPSRASLTRTPPRASLTMTPSTASLTRTPPRAS---PTGMPSRTSPTGMPSTASLT 203

Query: 365 GI-LEESMARRGSRKSMFTFVEKPKVTPNP---DLLDLVQTADEKRRQRDQGEVGVEEEP 420
            +    S+ R  SR S      +   T +P    L  +  TA   R        G+    
Sbjct: 204 KMDSTASITRTLSRASPTGTPPRASPTGSPPRASLSMMPSTALLIRTPPRASPTGMLSRT 263

Query: 421 FALGAEAS-NFQQEPAPRDRASPAAAEEVVPEWASCLKSPR----IQAKPKPKPNQNLSE 475
                +++ +  + P+    ASP       P  AS   +P     ++  P+  P   LS 
Sbjct: 264 SLTKMDSTASITRTPSRPSTASPTGT----PSRASLSMTPSTASLMRMLPRASPTGMLSR 319

Query: 476 ASGKGAELYARRQSRMEKYVIESSSHTP---ELARCPS-------PTMSLPS---SWKYP 522
            S           ++M+     S S TP    + R PS       P+ + P+   S   P
Sbjct: 320 TS----------LTKMDSTA--SISRTPPRASITRTPSRASPTGKPSTASPTGTPSRASP 367

Query: 523 TNAPGAFRV----ASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQL-RPSLFVLSPI 577
           T +P    +    ++ SP  TPP +   G      + R  P   P   L R S+  +   
Sbjct: 368 TGSPSTASLTGLSSTASPTGTPPRASPTGTPSTASLTRKPPRASPTGMLSRTSITKMDST 427

Query: 578 KEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAV 637
             P +  PRA+              P G  P +     PSR+SP    S    +  P+  
Sbjct: 428 ASPTRTPPRAS--------------PTGTPPRASPTGTPSRASPTGTQSTASPTGSPSTA 473

Query: 638 SPPYGGDISPVSPSRAWSPRAKQAPRPSFS-----------TRNAGIEAQVWKPS 681
           SP   G  S  SP+ + S RA     PS +           TR     +  W PS
Sbjct: 474 SPT--GSPSTASPTGSPS-RASLTRTPSRASLTKMESTASITRTPSRASPTWTPS 525


>gi|239749989 PREDICTED: otogelin isoform 2 [Homo sapiens]
          Length = 2852

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 108/418 (25%), Positives = 158/418 (37%), Gaps = 99/418 (23%)

Query: 33   NAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPP 92
            N  L  + GL    + E Q S  +P     H PA        +P+A LTT       NPP
Sbjct: 1405 NETLPPSQGLPTPSDEEPQLSQESPR-TPTHRPAL-------TPAAPLTTAL-----NPP 1451

Query: 93   ATD-----VNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGT-GPASK---PSTLCADGQP 143
             T      V+  P  T + Q L L++       +QLP+  T  PASK    S L     P
Sbjct: 1452 VTATEEPVVSPGPTQTTLQQPLELTA-------SQLPAGPTESPASKGVTASLLAIPHTP 1504

Query: 144  QAPAEEVRCSTLLIDKVSTPATTTST---FSREATLIPSSR-PPASDF--MSSSLLI--- 194
            ++ +  V   T     VS    TT     F+    +  SSR PPA  F  M+ ++ +   
Sbjct: 1505 ESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPLMTKAVTVRGH 1564

Query: 195  --------DIQPN-TLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGI 245
                     +QP+ T   S+    S  A + +PT   S           V++RT  P   
Sbjct: 1565 GSLPVRTTPLQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPT 1624

Query: 246  QAPGGTS-------------QMERSPML----------ERRHFGEKAP-----APQPPSL 277
            QA   +S             Q+  SP+           E+   G   P     +PQP  L
Sbjct: 1625 QAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPL 1684

Query: 278  PDRSPRPQRH--IMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVR 335
            P   PRP +H  + +RSP      +   +PA+         +  T T+ L+  P  S   
Sbjct: 1685 PSAPPRPAQHTTMATRSP-----ALPPETPAA--------ASLSTATDGLAATPFMSLES 1731

Query: 336  SPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNP 393
            + PS   L     P +S      +P +K G     +A  G + S+ T   +P+ T  P
Sbjct: 1732 TRPSQ--LLSGLPPDTS------LPLAKVG-TSAPVATPGPKASVITTPLQPQATTLP 1780



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 46/186 (24%), Positives = 68/186 (36%), Gaps = 20/186 (10%)

Query: 499  SSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGV-LRP 557
            + HT    R P+     P++    T   G       S   T P+ L  G  P+  + L  
Sbjct: 1692 AQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAK 1751

Query: 558  EPTKQPPYQLRPSLFVL-SPIKEPAKVSP-RAASPAKPSSLDLVPNLPKGALPPSPALPR 615
              T  P     P   V+ +P++  A   P +  SP  P      P     A PP+   P 
Sbjct: 1752 VGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLP----FTPAAMTQAHPPTHIAPP 1807

Query: 616  PSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEA 675
             + ++PGL       +L  + V P   G  S VS            PR S + + A +  
Sbjct: 1808 AAGTAPGLLLGA---TLPTSGVLPVAEGTASMVS----------VVPRKSTTGKVAILSK 1854

Query: 676  QVWKPS 681
            QV  P+
Sbjct: 1855 QVSLPT 1860


>gi|239749987 PREDICTED: otogelin isoform 1 [Homo sapiens]
          Length = 2924

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 108/418 (25%), Positives = 158/418 (37%), Gaps = 99/418 (23%)

Query: 33   NAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPP 92
            N  L  + GL    + E Q S  +P     H PA        +P+A LTT       NPP
Sbjct: 1477 NETLPPSQGLPTPSDEEPQLSQESPR-TPTHRPAL-------TPAAPLTTAL-----NPP 1523

Query: 93   ATD-----VNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGT-GPASK---PSTLCADGQP 143
             T      V+  P  T + Q L L++       +QLP+  T  PASK    S L     P
Sbjct: 1524 VTATEEPVVSPGPTQTTLQQPLELTA-------SQLPAGPTESPASKGVTASLLAIPHTP 1576

Query: 144  QAPAEEVRCSTLLIDKVSTPATTTST---FSREATLIPSSR-PPASDF--MSSSLLI--- 194
            ++ +  V   T     VS    TT     F+    +  SSR PPA  F  M+ ++ +   
Sbjct: 1577 ESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPLMTKAVTVRGH 1636

Query: 195  --------DIQPN-TLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGI 245
                     +QP+ T   S+    S  A + +PT   S           V++RT  P   
Sbjct: 1637 GSLPVRTTPLQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPT 1696

Query: 246  QAPGGTS-------------QMERSPML----------ERRHFGEKAP-----APQPPSL 277
            QA   +S             Q+  SP+           E+   G   P     +PQP  L
Sbjct: 1697 QAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPL 1756

Query: 278  PDRSPRPQRH--IMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVR 335
            P   PRP +H  + +RSP      +   +PA+         +  T T+ L+  P  S   
Sbjct: 1757 PSAPPRPAQHTTMATRSP-----ALPPETPAA--------ASLSTATDGLAATPFMSLES 1803

Query: 336  SPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNP 393
            + PS   L     P +S      +P +K G     +A  G + S+ T   +P+ T  P
Sbjct: 1804 TRPSQ--LLSGLPPDTS------LPLAKVG-TSAPVATPGPKASVITTPLQPQATTLP 1852



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 46/186 (24%), Positives = 68/186 (36%), Gaps = 20/186 (10%)

Query: 499  SSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGV-LRP 557
            + HT    R P+     P++    T   G       S   T P+ L  G  P+  + L  
Sbjct: 1764 AQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAK 1823

Query: 558  EPTKQPPYQLRPSLFVL-SPIKEPAKVSP-RAASPAKPSSLDLVPNLPKGALPPSPALPR 615
              T  P     P   V+ +P++  A   P +  SP  P      P     A PP+   P 
Sbjct: 1824 VGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLP----FTPAAMTQAHPPTHIAPP 1879

Query: 616  PSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEA 675
             + ++PGL       +L  + V P   G  S VS            PR S + + A +  
Sbjct: 1880 AAGTAPGLLLGA---TLPTSGVLPVAEGTASMVS----------VVPRKSTTGKVAILSK 1926

Query: 676  QVWKPS 681
            QV  P+
Sbjct: 1927 QVSLPT 1932


>gi|239743293 PREDICTED: mucin 12 [Homo sapiens]
          Length = 5478

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 139/644 (21%), Positives = 213/644 (33%), Gaps = 121/644 (18%)

Query: 44   LSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPAT 103
            LS+      SSP  P A   SPA+  +  ++  S T        SH+ P +        T
Sbjct: 3602 LSEKSTTFHSSPRSP-ATTLSPASTTSSGVSEESTT--------SHSRPGST-----HTT 3647

Query: 104  VVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTP 163
              P S     + ++S+ +      T     P++    G  Q        S      +S  
Sbjct: 3648 AFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGSSQESTTSHSSSGSTDTALSPG 3707

Query: 164  ATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYS 223
            +TT  +F +E+T   SS  P S             +T +       SG   A+T      
Sbjct: 3708 STTALSFGQESTTFHSS--PGS------------THTTLFPDSTTSSGIVEAST------ 3747

Query: 224  EVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPR 283
             VH +   P      T  P    +PG    ++      + H       P PPS       
Sbjct: 3748 RVHSSTGSP----RTTLSPASSTSPG----LQGESTAFQTHPASTHTTPSPPS------- 3792

Query: 284  PQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVL 343
                  + +  VE      RSP S   P  +F A  T   T   +  ++   S P  S  
Sbjct: 3793 ------TATAPVEESTTYHRSPGS--TPTTHFPASST---TSGHSEKSTIFHSSPDASGT 3841

Query: 344  YPSSDPKSSHLKGQAVP------ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLD 397
             PSS   ++  +G++        +++   L  S    G  ++  TF   P+ +P   L  
Sbjct: 3842 TPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPR-SPTTTLSP 3900

Query: 398  LVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLK 457
               T+           +GV EE     ++  +     +P    +P  +EE    ++S   
Sbjct: 3901 ASMTS-----------LGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSS--- 3946

Query: 458  SPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPS 517
                       P    +    +      RR+     +   +S+HT  L    S T  L  
Sbjct: 3947 ----------SPGSTETTVFPRSTTTSVRREEPTTFHSRPASTHT-TLFTEDSTTSGLTE 3995

Query: 518  SWKYPTNAPGAFRVASRSPARTP---PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVL 574
                 T  PG       SPA T    PA+L    L E     P  +     +L P+    
Sbjct: 3996 E---STAFPG-------SPASTQTGLPATLTTADLGEESTTFPSSSGSTGTKLSPARSTT 4045

Query: 575  SPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQD--SL 632
            S +     V     S   PSS +         LP SP  P  S  S   YTSP     +L
Sbjct: 4046 SGL-----VGESTPSRLSPSSTETT------TLPGSPTTPSLSEKSTTFYTSPRSPDATL 4094

Query: 633  QPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQ 676
             P   +     + S  S S+  S      P    ST  +G+  +
Sbjct: 4095 SPATTTSSGVSEESSTSHSQPGSTHTTAFPD---STTTSGLSQE 4135



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 129/613 (21%), Positives = 205/613 (33%), Gaps = 103/613 (16%)

Query: 75   SPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKP 134
            SP ATL+  T+ SS     +  + + P +    + P S+     S     S+ +  ++  
Sbjct: 2532 SPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDT 2591

Query: 135  STLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLI 194
            + L A      P++E   S       S+P +T +  S  +T   S    ++ F SS    
Sbjct: 2592 TLLPASTTTSGPSQESTTSH------SSPGSTDTALSPGSTTALSFGQESTTFHSS---- 2641

Query: 195  DIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQM 254
                +T +       SG   A+T       VH +   P      T  P    +PG    +
Sbjct: 2642 PGSTHTTLFPDSTTSSGIVEAST------RVHSSTGSP----RTTLSPASSTSPG----L 2687

Query: 255  ERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGN 314
            +      + H       P PPS             + +  VE      RSP S   P  +
Sbjct: 2688 QGESTTFQTHPASTHTTPSPPS-------------TATAPVEESTTYHRSPGS--TPTTH 2732

Query: 315  FTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVP------ASKTGILE 368
            F A  T   T   +  ++   S P  S   PSS   ++  +G++        +++   L 
Sbjct: 2733 FPASST---TSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLP 2789

Query: 369  ESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEAS 428
             S    G  ++  TF   P+ +P   L     T+           +GV EE     ++  
Sbjct: 2790 GSTTTPGLSEASTTFYSSPR-SPTTTLSPASMTS-----------LGVGEESTTSRSQPG 2837

Query: 429  NFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQ 488
            +     +P    +P  +EE    ++S   S      P+       +   G+    +  R 
Sbjct: 2838 STHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPR----STTTSVRGEEPTTFHSRP 2893

Query: 489  SRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTP---PASLY 545
            +     +    S T  L              +  T  PG       SPA T    PA+L 
Sbjct: 2894 ASTHTTLFTEDSTTSGLT-------------EESTAFPG-------SPASTQTGLPATLT 2933

Query: 546  HGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKG 605
               L E     P  +      L P+    S +     V     S   PSS +        
Sbjct: 2934 TADLGEESTTFPSSSGSTGTTLSPARSTTSGL-----VGESTPSRLSPSSTETT------ 2982

Query: 606  ALPPSPALPRPSRSSPGLYTSPGQD--SLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPR 663
             LP SP  P  S  S   YTSP     +L P   +     + S  S S+  S      P 
Sbjct: 2983 TLPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPD 3042

Query: 664  PSFSTRNAGIEAQ 676
               ST  +G+  +
Sbjct: 3043 ---STTTSGLSQE 3052



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 132/630 (20%), Positives = 206/630 (32%), Gaps = 118/630 (18%)

Query: 44   LSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPAT 103
            LS+      SSP  P A   SPA+  +  ++  S T       S   P +T     P +T
Sbjct: 962  LSERSTTFHSSPRSP-ATTLSPASTTSSGVSEESTT-------SRSRPGSTHTTAFPDST 1013

Query: 104  VVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTP 163
              P       + ++S+ +      T     P++    G  Q        S      +S  
Sbjct: 1014 TTP------GLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSSGSTDTALSPG 1067

Query: 164  ATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYS 223
            +TT  +F +E+T   S+  P S             +T +       SG   A+T      
Sbjct: 1068 STTALSFGQESTTFHSN--PGS------------THTTLFPDSTTSSGIVEAST------ 1107

Query: 224  EVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPR 283
             VH +   P      T  P    +PG    ++      + H       P PPS       
Sbjct: 1108 RVHSSTGSP----RTTLSPASSTSPG----LQGESTAFQTHPASTHTTPSPPS------- 1152

Query: 284  PQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVL 343
                  + +  VE      RSP S   P  +F A  T   T   +  ++   S P  S  
Sbjct: 1153 ------TATAPVEESTTYHRSPGS--TPTTHFPASST---TSGHSEKSTIFHSSPDASGT 1201

Query: 344  YPSSDPKSSHLKGQAVP------ASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLD 397
             PSS   ++  +G++        +++   L  S    G  ++  TF   P+ +P   L  
Sbjct: 1202 TPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPR-SPTTTLSP 1260

Query: 398  LVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLK 457
               T+           +GV EE     ++  +     +P    +P  +EE    ++    
Sbjct: 1261 ASMTS-----------LGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYS---- 1305

Query: 458  SPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPS 517
            S R   +    P+   +   G+    +  R +     +    S T  L            
Sbjct: 1306 SSRGSTETTVFPHSTTTSVHGEEPTTFHSRPASTHTTLFTEDSTTSGLT----------- 1354

Query: 518  SWKYPTNAPGAFRVASRSPARTP---PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVL 574
              +  T  PG       SPA T    PA+L    L E     P  +     +L P+    
Sbjct: 1355 --EESTAFPG-------SPASTQTGLPATLTTADLGEESTTFPSSSGSTGTKLSPARSTT 1405

Query: 575  SPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQD--SL 632
            S +     V     S   PSS +         LP SP  P  S  S   YTSP     +L
Sbjct: 1406 SGL-----VGESTPSRLSPSSTETT------TLPGSPTTPSLSEKSTTFYTSPRSPDATL 1454

Query: 633  QPTAVSPPYGGDISPVSPSRAWSPRAKQAP 662
             P   +     + S  S S+  S      P
Sbjct: 1455 SPATTTSSGVSEESSTSHSQPGSTHTTAFP 1484



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 134/631 (21%), Positives = 208/631 (32%), Gaps = 120/631 (19%)

Query: 44   LSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPAT 103
            LS+      SSP  P A   SPA+  +  ++  S T        SH+ P +        T
Sbjct: 2045 LSEKSTTFHSSPRSP-ATTLSPASTTSSGVSEESTT--------SHSRPGST-----HTT 2090

Query: 104  VVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTP 163
              P S     + ++S+ +      T     P++    G P   +     S    D   +P
Sbjct: 2091 AFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSG-PSQESTTSHSSPGSTDTALSP 2149

Query: 164  ATTTS-TFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVY 222
             +TT+ +F +E+T   SS  P S             +T +       SG   A+T     
Sbjct: 2150 GSTTALSFGQESTTFHSS--PGST------------HTTLFPDSTTSSGIVEAST----- 2190

Query: 223  SEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSP 282
              VH +   P +    T  P    +PG    ++      + H       P PPS      
Sbjct: 2191 -RVHSSTGSPRT----TLSPASSTSPG----LQGESTAFQTHPASTHTTPSPPS------ 2235

Query: 283  RPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSV 342
                   + +  VE      RSP S   P  +F A  T   T   +  ++   S P  S 
Sbjct: 2236 -------TATAPVEESTTYHRSPGST--PTTHFPASST---TSGHSEKSTIFHSSPDASG 2283

Query: 343  LYPSSDPKSSHLKGQAVPA------SKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLL 396
              PSS   ++  +G++  +      ++   L  S    G  ++  TF   P+ +P   L 
Sbjct: 2284 TTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPR-SPTTTLS 2342

Query: 397  DLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCL 456
                T+           +GV EE     ++  +     +P    +P  +EE    ++S  
Sbjct: 2343 PASMTS-----------LGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSP 2391

Query: 457  KSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLP 516
             S      P+       +   G+    +  R +     +    S T  L           
Sbjct: 2392 GSTETTVFPRTPT----TSVRGEEPTTFHSRPASTHTTLFTEDSTTSGLT---------- 2437

Query: 517  SSWKYPTNAPGAFRVASRSPARTP---PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFV 573
               +  T  PG       SPA T    PA+L    L E     P  +      L P+   
Sbjct: 2438 ---EESTAFPG-------SPASTQTGLPATLTTADLGEESTTFPSSSGSTGTTLSPARST 2487

Query: 574  LSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQD--S 631
             S +     V     S   PSS +         LP SP  P  S  S   YTSP     +
Sbjct: 2488 TSGL-----VGESTPSRLSPSSTETT------TLPGSPTTPSLSEKSTTFYTSPRSPDAT 2536

Query: 632  LQPTAVSPPYGGDISPVSPSRAWSPRAKQAP 662
            L P   +     + S  S S+  S      P
Sbjct: 2537 LSPATTTSSGVSEESSTSHSQPGSTHTTAFP 2567



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 143/655 (21%), Positives = 220/655 (33%), Gaps = 114/655 (17%)

Query: 43   HLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTS------------NSSHN 90
            H S         PA      HS  + +  +  SP A+ TTP+S             S  +
Sbjct: 2722 HRSPGSTPTTHFPASSTTSGHSEKSTIFHS--SPDASGTTPSSAHSTTSGRGESTTSRIS 2779

Query: 91   PPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEV 150
            P +T++   P +T  P     S+   +S  +  P+    PAS  S     G+    +   
Sbjct: 2780 PGSTEITTLPGSTTTPGLSEASTTFYSSPRS--PTTTLSPASMTSL--GVGEESTTSRSQ 2835

Query: 151  RCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFM-----SSSLLIDIQPNTL---- 201
              ST     VS  +TTT   S E+T + SS P +++       +++ +   +P T     
Sbjct: 2836 PGSTH--STVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRSTTTSVRGEEPTTFHSRP 2893

Query: 202  ------VVSADQEMSGRAAATT-----PTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGG 250
                  + + D   SG    +T     P    + +  TL         T  P    + G 
Sbjct: 2894 ASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEESTTFPSSSGSTGT 2953

Query: 251  TSQMERSPMLERRHFGEKAPA---------------PQPPSLPDRS------PRPQRHIM 289
            T    RS        GE  P+               P  PSL ++S      PR     +
Sbjct: 2954 TLSPARSTTSGL--VGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATL 3011

Query: 290  SRSPMVERRMMGQRSPASERRPLGNFTAPPTYTET--LSTAPLASWVRSPPSYSVLYPSS 347
            S +      +  + S +  +    + TA P  T T  LS  P AS      + + L P S
Sbjct: 3012 SPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTASHSSQGSTEATLSPGS 3071

Query: 348  DPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRR 407
               SS  +      S  G  E ++    +  S       P  +    L   +  A     
Sbjct: 3072 TTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASST-- 3129

Query: 408  QRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKP 467
                   G++EE     +  S+    P+P    + AA  EV         S    ++P  
Sbjct: 3130 -----SAGLQEESTTFQSWPSSSDTTPSPP--GTTAAPVEV---------STTYHSRPSS 3173

Query: 468  KPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCP--SPTMSLPSSWKYPTNA 525
             P  + S +S        R +   E   + SS      A  P  S T  L      PT +
Sbjct: 3174 TPTTHFSASS----TTLGRSE---ESTTVHSSPGATGTALFPTRSATSVLVGE---PTTS 3223

Query: 526  PGAFRVASRSPARTP-PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVS 584
            P    ++S S   T  P S     L E         + P   L P+    S + E +   
Sbjct: 3224 P----ISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEES--- 3276

Query: 585  PRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSP 639
                S ++P S          A P S  +P  S+ S   ++SPG      T +SP
Sbjct: 3277 --TTSHSRPGSTHTT------AFPGSTTMPGVSQESTASHSSPGSTD---TTLSP 3320



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 125/624 (20%), Positives = 207/624 (33%), Gaps = 106/624 (16%)

Query: 59   PAEVHSPAADVNQNLAS---PSATLTTPTSNSSHNPPATDVN-------QNPPATVVPQS 108
            P+  HS  +   ++  S   P +T  T    S+  P  ++ +       ++P  T+ P S
Sbjct: 3843 PSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPAS 3902

Query: 109  LPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS 168
            +    + + S+ ++     T     P++    G  +        S    +    P +TT+
Sbjct: 3903 MTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRSTTT 3962

Query: 169  TFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATT-----PTKVYS 223
            +  RE      SRP ++             +T + + D   SG    +T     P    +
Sbjct: 3963 SVRREEPTTFHSRPAST-------------HTTLFTEDSTTSGLTEESTAFPGSPASTQT 4009

Query: 224  EVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRH--FGEKAPA---------- 271
             +  TL         T  P    +  G++  + SP         GE  P+          
Sbjct: 4010 GLPATLTTADLGEESTTFP----SSSGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETT 4065

Query: 272  -----PQPPSLPDRS------PRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPT 320
                 P  PSL ++S      PR     +S +      +  + S +  +    + TA P 
Sbjct: 4066 TLPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPD 4125

Query: 321  YTET--LSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRK 378
             T T  LS  P  S      + + L P S   SS  +      S  G  E ++    +  
Sbjct: 4126 STTTSGLSQEPTTSHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTIT 4185

Query: 379  SMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRD 438
            S       P  +    L   +  A            G++EE       ++ FQ  P+  D
Sbjct: 4186 SGLVEASTPTHSSTGSLHTTLTPASST-------STGLQEE-------STTFQSWPSSSD 4231

Query: 439  RASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIES 498
                  +   VP   S        ++P   P  + S +S        R +   E   + S
Sbjct: 4232 TTPSPPSTTAVPVEVSTT----YHSRPSSTPTTHFSASS----TTLGRSE---ESTTVHS 4280

Query: 499  SSHTPELARCP--SPTMSLPSSWKYPTNAPGAFRVASRSPARTP-PASLYHGYLPENGVL 555
            S      A  P  S T  L      PT +P    ++S S   T  P S     L E    
Sbjct: 4281 SPGATGTALFPTRSATSVLVGE---PTTSP----ISSGSTETTALPGSTTTAGLSEKSTT 4333

Query: 556  RPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPR 615
                 + P   L P+    S + E +       S ++P S+         A P S  +P 
Sbjct: 4334 FYSSPRSPDTTLSPASTTSSGVSEES-----TTSHSRPGSMHTT------AFPSSTTMPG 4382

Query: 616  PSRSSPGLYTSPGQDSLQPTAVSP 639
             S+ S   ++SPG      T +SP
Sbjct: 4383 VSQESTASHSSPGSTD---TTLSP 4403



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 74/341 (21%), Positives = 121/341 (35%), Gaps = 64/341 (18%)

Query: 84  TSNSSHNPPATDVNQNPPATVV---------------PQSLPLSSIQQNSSEAQLPSNGT 128
           ++NS H+  +T  +  P AT                 P++ P++S    ++     +   
Sbjct: 215 STNSGHSEESTVSHSGPGATGTTLFPSHSATSVFVGEPKTSPITSASMETTALPGSTTTA 274

Query: 129 GPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRP------ 182
           G + K +T  +   P++P           D+  +PA TTS+   E +    SRP      
Sbjct: 275 GLSEKSTTFYSS--PRSP-----------DRTLSPARTTSSGVSEKSTTSHSRPGPTHTI 321

Query: 183 --PASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTA 240
             P S  M          +++  S D  +S     TTP+ +  E   T    P     T 
Sbjct: 322 AFPDSTTMPGVSQESTASHSIPGSTDTTLS--PGTTTPSSLGPE-STTFHSSPGYTKTTR 378

Query: 241 RPFGIQAPG------------GTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHI 288
            P      G            G+     SP     H GE       PS  D SP P    
Sbjct: 379 LPDNTTTSGLLEASTPVHSSTGSPHTTLSPSSSTTHEGEPTTFQSWPSSKDTSPAPSG-- 436

Query: 289 MSRSPMVERRMMGQRSPASERRPLGNFTAPPT------YTETLSTAPLASWVRSPPSYSV 342
            + S  V+       SP+S   P  +F+A  T       +  + ++P+A+    PP+ S 
Sbjct: 437 -TTSAFVKLSTTYHSSPSS--TPTTHFSASSTTLGHSEESTPVHSSPVATATTPPPARSA 493

Query: 343 LYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTF 383
              S   + S    ++  +++T    ES    G  +   TF
Sbjct: 494 --TSGHVEESTAYHRSPGSTQTMHFPESSTTSGHSEESATF 532



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 138/652 (21%), Positives = 214/652 (32%), Gaps = 108/652 (16%)

Query: 43   HLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTS------------NSSHN 90
            H S         PA      HS  + +  +  SP A+ TTP+S             S  +
Sbjct: 1165 HRSPGSTPTTHFPASSTTSGHSEKSTIFHS--SPDASGTTPSSAHSTTSGRGESTTSRIS 1222

Query: 91   PPATDVNQNPPATVVPQSLPLSSIQQNS--------SEAQLPSNGTGPASKPSTLCADGQ 142
            P +T++   P +T  P     S+   +S        S A + S G G  S  S     G 
Sbjct: 1223 PGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSR-SQPGS 1281

Query: 143  PQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLID--IQPNT 200
              +       +T  + + ST   ++S  S E T+ P S   +      +         +T
Sbjct: 1282 THSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFPHSTTTSVHGEEPTTFHSRPASTHT 1341

Query: 201  LVVSADQEMSGRAAATT-----PTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQME 255
             + + D   SG    +T     P    + +  TL         T  P    +  G++  +
Sbjct: 1342 TLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEESTTFP----SSSGSTGTK 1397

Query: 256  RSPMLERRH--FGEKAPA---------------PQPPSLPDRS------PRPQRHIMSRS 292
             SP         GE  P+               P  PSL ++S      PR     +S +
Sbjct: 1398 LSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPA 1457

Query: 293  PMVERRMMGQRSPASERRPLGNFTAPP--TYTETLSTAPLASWVRSPPSYSVLYPSSDPK 350
                  +  + S +  +    + TA P  T T  LS  P  S      + + L P S   
Sbjct: 1458 TTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSDLSQEPTTSHSSQGSTEATLSPGSTTA 1517

Query: 351  SSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRD 410
            SS  +      S  G  E ++    +  S       P  +    L   +  A        
Sbjct: 1518 SSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASST----- 1572

Query: 411  QGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPN 470
                G++EE     +  S+    P+P    + AA  EV         S    ++P   P 
Sbjct: 1573 --SAGLQEESTTFQSWPSSSDTTPSPP--GTTAAPVEV---------STTYHSRPSSTPT 1619

Query: 471  QNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCP--SPTMSLPSSWKYPTNAPGA 528
             + S +S        R +   E   + SS      A  P  S T  L      PT +P  
Sbjct: 1620 THFSASS----TTLGRSE---ESTTVHSSPGATGTALFPTRSATSVLVGE---PTTSP-- 1667

Query: 529  FRVASRSPARTP-PASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRA 587
              ++S S   T  P S     L E         + P   L P+    S + E +      
Sbjct: 1668 --ISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEES-----T 1720

Query: 588  ASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSP 639
             S ++P S          A P S  +P  S+ S   ++SPG      T +SP
Sbjct: 1721 TSHSRPGSTHTT------AFPGSTTMPGVSQESTASHSSPGSTD---TTLSP 1763



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 149/670 (22%), Positives = 221/670 (32%), Gaps = 104/670 (15%)

Query: 45   SQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTT----PTSNSSHNPPATDVNQNP 100
            S +  A  SS   P     S A+      +SP +T TT     T+ SS  P +T  + +P
Sbjct: 4368 SMHTTAFPSSTTMPGVSQESTASH-----SSPGSTDTTLSPGSTTASSLGPESTTFHSSP 4422

Query: 101  PATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKV 160
             +T     LP ++      EA  P + +   S  +TL   G      E     +    K 
Sbjct: 4423 GSTETTL-LPDNTTASGLLEASTPVHSS-TGSPHTTLSPAGSTTRQGESTTFQSWPNSKD 4480

Query: 161  STPA--TTTSTFSREATLI---PSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAA 215
            +TPA  TTTS F   +T     PSS P      SS+ L   + +T V S     S  A A
Sbjct: 4481 TTPAPPTTTSAFVELSTTSHGSPSSTPTTHFSASSTTLGRSEESTTVHS-----SPVATA 4535

Query: 216  TTPTKVYSE--------------------VHFTLAKPPS------VVNRTARPFGIQ-AP 248
            TTP+   S                     +HF  +   S        + ++    I  AP
Sbjct: 4536 TTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESNTTSGRGEESTTSHSSTTHTISSAP 4595

Query: 249  GGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASE 308
              TS +   P       G  A    P S    S R +    S S       +   + ++ 
Sbjct: 4596 STTSALVEEPTSYHSSPGSTATTHFPDS-STTSGRSEESTASHSSQDATGTIVLPARSTT 4654

Query: 309  RRPLGNFTAPPTYTETLSTAPLASWVRSP--PSYSVLYPSSDPKSSHLKGQAVPASKTGI 366
               LG  T  P  + ++ T  L     +P     S  + SS P S+     +  ++  G 
Sbjct: 4655 SVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSS-PSSTPTTHFSASSTTLGR 4713

Query: 367  LEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAE 426
             EES     S  +  T       TP+P         +E            +   F   + 
Sbjct: 4714 SEESTTVHSSPVATAT-------TPSPARSTTSGLVEESTAYHSSPG-STQTMHFPESST 4765

Query: 427  ASNFQQEPAPRDRAS-------PAAAEEVVPEWASCLKSP-RIQAKPKPKPNQNLSEASG 478
            AS   +E      ++       P+    +V E  S   SP  I     P+     S  SG
Sbjct: 4766 ASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSIATTHFPES----STTSG 4821

Query: 479  KGAELYARRQSRMEKYVIESSSHTPELARCPSPTM------SLPSSWKYPTNAPGA---- 528
            +  E  A   S     +    +H     R    T       S+ ++       PG     
Sbjct: 4822 RSEESTASHSSPDTNGITPLPAHFTTSGRIAESTTFYISPGSMETTLASTATTPGLSAKS 4881

Query: 529  --FRVASRSPART-------------PPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFV 573
                 +SRSP +T              P SLY      +    P  T         + F 
Sbjct: 4882 TILYSSSRSPDQTLSPASMTSSSISGEPTSLYSQAESTHTTAFPASTTTSGLSQESTTFH 4941

Query: 574  LSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGAL-----PPSPALPRPSRSSPGLYTSPG 628
              P      +SP + + +  +     P+   G+      P S  +P  S  S   Y+SPG
Sbjct: 4942 SKPGSTETTLSPGSITTSSFAQEFTTPHSQPGSALSTVSPASTTVPGLSEESTTFYSSPG 5001

Query: 629  QDSLQPTAVS 638
              S + TA S
Sbjct: 5002 --STETTAFS 5009



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 88/445 (19%), Positives = 143/445 (32%), Gaps = 68/445 (15%)

Query: 25   PLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPT 84
            P+      + A  T +GL   +   A  SSP      +H P +      +  S T  + T
Sbjct: 4724 PVATATTPSPARSTTSGL--VEESTAYHSSPGSTQT-MHFPESSTASGRSEESRTSHSST 4780

Query: 85   SNSSHNPPATDVN--------QNPPATVVPQSLPLSSIQQNSSEAQLPSNGT----GPAS 132
            +++  +PP+T            + P ++     P SS     SE    S+ +    G   
Sbjct: 4781 THTISSPPSTTSALVEEPTSYHSSPGSIATTHFPESSTTSGRSEESTASHSSPDTNGITP 4840

Query: 133  KPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSL 192
             P+     G+             +   +++ ATT    ++   L  SSR P      +S+
Sbjct: 4841 LPAHFTTSGRIAESTTFYISPGSMETTLASTATTPGLSAKSTILYSSSRSPDQTLSPASM 4900

Query: 193  L---IDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPG 249
                I  +P +L   A+   +    A+T T   S+   T    P     T  P  I    
Sbjct: 4901 TSSSISGEPTSLYSQAESTHTTAFPASTTTSGLSQESTTFHSKPGSTETTLSPGSITTSS 4960

Query: 250  ------------GTSQMERSP-------MLERRHFGEKAPAPQPPSLPDRSPRPQRHIMS 290
                        G++    SP       + E       +P     +    S     H   
Sbjct: 4961 FAQEFTTPHSQPGSALSTVSPASTTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQ 5020

Query: 291  RSPMVER--------------RMMGQRSPASERRPLGNFTAPPTYTETLSTA---PLASW 333
             +P  +                 +GQ S A         T P     T S     P   +
Sbjct: 5021 STPFPDSPGFTHTVLPATLTTTDIGQESTAFHSSSDATGTTPLPARSTASDLVGEPTTFY 5080

Query: 334  VRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKV-TPN 392
            +   P+Y+ L+P+S             +S +G+ EES     S     T V    + T  
Sbjct: 5081 ISPSPTYTTLFPAS-------------SSTSGLTEESTTFHTSPSFTSTIVSTESLETLA 5127

Query: 393  PDLLDLVQTADEKRRQRDQGEVGVE 417
            P L    Q  + K+    QG VG +
Sbjct: 5128 PGLCQEGQIWNGKQCVCPQGYVGYQ 5152



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 125/639 (19%), Positives = 191/639 (29%), Gaps = 114/639 (17%)

Query: 62   VHSPAADVNQNLASPSATLTTPTSNSSHN-PPATDVNQNPPATVV------------PQS 108
            VHS     +  L+   +T     S + H+ P + D    PP T              P S
Sbjct: 751  VHSSTRSPHTTLSPAGSTTRQGESTTFHSWPSSKDTRPAPPTTTSAFVEPSTTSHGSPSS 810

Query: 109  LPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTS 168
            +P + I   S+ + L    T   S P +      P++     R         ST  T +S
Sbjct: 811  IPTTHISARSTTSGLVEESTTYHSSPGSTQTMHFPESDTTSGRGEESTTSHSSTTHTISS 870

Query: 169  TFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFT 228
              S  + L+    P +      S      P++         SGR+  +T +    +   T
Sbjct: 871  APSTTSALV--EEPTSYHSSPGSTATTHFPDS------STTSGRSEESTASHSSQDATGT 922

Query: 229  LAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHI 288
            +  P              +P  +  ME + +           +   P L +RS       
Sbjct: 923  IVLPARSTTSVLLGESTTSPISSGSMETTAL---------PGSTTTPGLSERST-----T 968

Query: 289  MSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSD 348
               SP         RSPA+   P                   AS   S  S       S 
Sbjct: 969  FHSSP---------RSPATTLSP-------------------ASTTSSGVSEESTTSRSR 1000

Query: 349  PKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQ 408
            P S+H        +  G+   S     S  S  T +  P  T          T+      
Sbjct: 1001 PGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTL-LPASTTTSGPSQESTTSHSSSGS 1059

Query: 409  RDQGEVGVEEEPFALGAEASNFQQEPAPR------DRASPAAAEEVVPEWASCLKSPRIQ 462
             D           + G E++ F   P         D  + +   E      S   SPR  
Sbjct: 1060 TDTALSPGSTTALSFGQESTTFHSNPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTT 1119

Query: 463  AKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYP 522
              P    +  L    G+                  +S+HT      PSP    PS+   P
Sbjct: 1120 LSPASSTSPGL---QGESTAFQTH----------PASTHT-----TPSP----PSTATAP 1157

Query: 523  TNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAK 582
                  +    RSP  TP       + P +        K   +   P     +P    + 
Sbjct: 1158 VEESTTYH---RSPGSTPTT-----HFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHST 1209

Query: 583  VSPRAASPA---KPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQ--DSLQPTAV 637
             S R  S      P S ++        LP S   P  S +S   Y+SP     +L P ++
Sbjct: 1210 TSGRGESTTSRISPGSTEIT------TLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASM 1263

Query: 638  SPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQ 676
            +    G+ S  S S+  S  +  +P    ST   G+  +
Sbjct: 1264 TSLGVGEESTTSRSQPGSTHSTVSPA---STTTPGLSEE 1299


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 70/337 (20%), Positives = 108/337 (32%), Gaps = 46/337 (13%)

Query: 53   SSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATV-------- 104
            ++P+PPP    +       +   P+ T TTP   ++ +PP T     PP T         
Sbjct: 1404 TTPSPPPTSTTTLPPTTTPS--PPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTT 1461

Query: 105  ---VPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVS 161
                P + P       S     PS  T   + P        P         ST  +   +
Sbjct: 1462 TTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTT 1521

Query: 162  TPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATT---- 217
            TP+  T+T         ++ PP +   S      I P T   +     +     TT    
Sbjct: 1522 TPSPPTTT---------TTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTP 1572

Query: 218  -PTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPS 276
             PT   S    T   PP++   T  P    +P  T+     P             P PP+
Sbjct: 1573 PPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPP----------TTTPSPPT 1622

Query: 277  LPDRSPRPQRHIM--SRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLA--- 331
                +P      +  + +P           P +   P    T  P  T T +  P     
Sbjct: 1623 TTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPS 1682

Query: 332  ---SWVRSPPSYSVLYPS-SDPKSSHLKGQAVPASKT 364
               +   SPP+ ++  PS +   SS +     P+S T
Sbjct: 1683 SPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTT 1719



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 65/293 (22%), Positives = 97/293 (33%), Gaps = 31/293 (10%)

Query: 53   SSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLS 112
            ++  PPP    SP      +   P+ T TTP   ++ +PP T     PP T  P     +
Sbjct: 1568 TTTTPPPTTTPSPPTTTTPS--PPTITTTTPPPTTTPSPPTTTTT-TPPPTTTPSPPTTT 1624

Query: 113  SIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSR 172
             I   +S   LP   T P+  P+T         P+     +       S P TTT+T   
Sbjct: 1625 PITPPTSTTTLPPT-TTPSPPPTTTTTPPPTTTPSPPTTTTP------SPPITTTTT--- 1674

Query: 173  EATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKP 232
                     PP +   SS +     P T  ++     +  ++  T T   S    T   P
Sbjct: 1675 ---------PPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSST--TTPSP 1723

Query: 233  PSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRS 292
            P     T  P    +P  T+     P             P PPS+   +  P       +
Sbjct: 1724 PPTTMTTPSPTTTPSPPTTTMTTLPPTTTS---SPLTTTPLPPSITPPTFSPFSTTTPTT 1780

Query: 293  PMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYP 345
            P V   +          +P  NF  P   TE +       W  +    + +YP
Sbjct: 1781 PCVP--LCNWTGWLDSGKP--NFHKPGGDTELIGDVCGPGWAANISCRATMYP 1829



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 76/338 (22%), Positives = 112/338 (33%), Gaps = 41/338 (12%)

Query: 53   SSPAPPPAEVHSPAADVNQN---LASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSL 109
            ++  PPP    SP            +PS   TTP+  ++   P T     PP T  P   
Sbjct: 1444 TTTTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPP 1503

Query: 110  PLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTST 169
              + I   +S   LP   T   S P+T      P         + +      TP T+T+T
Sbjct: 1504 TTTPITPPASTTTLPPTTT--PSPPTTTTTTPPPTTTPSPPTTTPI------TPPTSTTT 1555

Query: 170  FSREATLIP----SSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATT------PT 219
                 T  P    ++ PP +   S        P T+  +     +  +  TT      PT
Sbjct: 1556 LPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPT 1615

Query: 220  KVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQ------ 273
               S    T   PP+    T  P    +P  T+     P           P+P       
Sbjct: 1616 TTPSPPTTTPITPPTSTT-TLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTT 1674

Query: 274  -PPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASE-RRPLGNFTAP-----PTYTETLS 326
             PP+    SP      ++ +P      M   SP +    P+   T P     P+   T  
Sbjct: 1675 PPPTTTPSSP------ITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTM 1728

Query: 327  TAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKT 364
            T P  +   SPP+ ++        SS L    +P S T
Sbjct: 1729 TTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSIT 1766



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 71/301 (23%), Positives = 101/301 (33%), Gaps = 31/301 (10%)

Query: 53   SSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLS 112
            ++  PPP    SP         +P A+ TT    ++ +PP T     PP T  P     +
Sbjct: 1490 TTTTPPPTTTPSPPTTTP---ITPPASTTTLPPTTTPSPPTTTTT-TPPPTTTPSPPTTT 1545

Query: 113  SIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSR 172
             I   +S   LP   T P+  P+T         P+     +       S P  TT+T   
Sbjct: 1546 PITPPTSTTTLPPT-TTPSPPPTTTTTPPPTTTPSPPTTTTP------SPPTITTTTPPP 1598

Query: 173  EATLIP----SSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATT-----PTKVYS 223
              T  P    ++ PP +   S      I P T   +     +     TT     PT   S
Sbjct: 1599 TTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPS 1658

Query: 224  EVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPR 283
                T   PP  +  T  P     P        SP             P  P     +P 
Sbjct: 1659 PPTTTTPSPP--ITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPS 1716

Query: 284  PQRHIMSRSPMVERRMMGQRSPASERRP--LGNFTAPPTYTET-LSTAPLASWVRSPPSY 340
                  + +P      M   SP +   P      T PPT T + L+T PL   + +PP++
Sbjct: 1717 -----STTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSI-TPPTF 1770

Query: 341  S 341
            S
Sbjct: 1771 S 1771



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 65/329 (19%), Positives = 105/329 (31%), Gaps = 42/329 (12%)

Query: 54   SPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQN--------PPATVV 105
            +P P P    +P       + + +    TPT   +  P  T +           P  T  
Sbjct: 3932 TPTPTPTGTQTPTTTP---ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3988

Query: 106  PQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPAT 165
            P + P+++     +    P+    P + P T      P       +  T      +TP T
Sbjct: 3989 PTTTPITTTT-TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT------TTPIT 4041

Query: 166  TTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEV 225
            TT+T +   T   +  P  +   +++ +      T   +            TPT   +  
Sbjct: 4042 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 4101

Query: 226  HFTLAKP---PSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSP 282
                  P    + V  T  P G Q P  T     + +          P P     P  +P
Sbjct: 4102 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTP 4154

Query: 283  RPQRHIMSRSPMVERRMMGQRSPASERR-------PLGNFTAPPTYTETLSTAPLASWVR 335
                  ++ +P          +P +          P G  T PPT+T   STAP+A    
Sbjct: 4155 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTGPPTHT---STAPIAELTT 4211

Query: 336  SPPSYSVLYPSSDPKSSHLKGQAVPASKT 364
            S P       SS P++S      +  S T
Sbjct: 4212 SNPPPE----SSTPQTSRSTSSPLTESTT 4236



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 111/635 (17%), Positives = 192/635 (30%), Gaps = 85/635 (13%)

Query: 54   SPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQN--------PPATVV 105
            +P P P    +P       + + +    TPT   +  P  T +           P  T  
Sbjct: 3725 TPTPTPTGTQTPTTTP---ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3781

Query: 106  PQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPAT 165
            P + P+++     +    P+    P + P T      P       +  T      +TP T
Sbjct: 3782 PTTTPITTTT-TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT------TTPIT 3834

Query: 166  TTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEV 225
            TT+T +   T   +  P  +   +++ +      T   +            TPT   +  
Sbjct: 3835 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3894

Query: 226  HFTLAKP---PSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSP 282
                  P    + V  T  P G Q P  T     + +          P P     P  +P
Sbjct: 3895 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTP 3947

Query: 283  RPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSV 342
                  ++ +P          +P   + P    T P T T T++  P  +  ++P +  +
Sbjct: 3948 ITTTTTVTPTP----------TPTGTQTPT---TTPITTTTTVTPTPTPTGTQTPTTTPI 3994

Query: 343  LYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTA 402
               ++   +    G   P + T I         +  +  T    P  T  P    +  T 
Sbjct: 3995 TTTTTVTPTPTPTGTQTPTT-TPI---------TTTTTVTPTPTPTGTQTPTTTPITTTT 4044

Query: 403  DEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQ 462
                     G       P       +     P P    +P           +   +P   
Sbjct: 4045 TVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 4101

Query: 463  AKPKPKPNQNLSEASGKGAELYARRQSR--MEKYVIESSSHTPELARCPSPTMSLPSSWK 520
              P   P    +  +        +  +   +      + + TP   + P+ T    ++  
Sbjct: 4102 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 4161

Query: 521  YPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEP 580
             PT  P      +++P  TP        +     + P PT        P+    +PI E 
Sbjct: 4162 TPTPTP----TGTQTPTTTP--------ITTTTTVTPTPTPTGTQTGPPTHTSTAPIAEL 4209

Query: 581  AKVSP----------RAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQD 630
               +P          R+ S     S  L+  LP       PA+   S + P   T+P   
Sbjct: 4210 TTSNPPPESSTPQTSRSTSSPLTESTTLLSTLP-------PAIEMTSTAPPSTPTAPTTT 4262

Query: 631  SLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPS 665
            S   T   PP      P +P+R  +  +  AP PS
Sbjct: 4263 SGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPS 4297



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 49/196 (25%), Positives = 71/196 (36%), Gaps = 30/196 (15%)

Query: 498  SSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPART------------PPASLY 545
            S++ TP     PSP  + PS    PT  P      + +P  T            PPAS  
Sbjct: 1459 STTTTPPPTTTPSPPTTTPSP---PTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTT 1515

Query: 546  HGYLPENGVLRPEPTKQ--PPYQLRPSLFVLSPIKEPAKVS--PRAASPAKPSSLDLVPN 601
               LP      P  T    PP    PS    +PI  P   +  P   +P+ P +    P 
Sbjct: 1516 T--LPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPP 1573

Query: 602  LPKGALPPSPALPRP---SRSSPGLYTSPGQDSLQPTAV------SPPYGGDISPVSPSR 652
                  PP+   P P   + ++P   T+P   +   T        SPP    I+P + + 
Sbjct: 1574 PTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTT 1633

Query: 653  AWSPRAKQAPRPSFST 668
               P    +P P+ +T
Sbjct: 1634 TLPPTTTPSPPPTTTT 1649



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 61/323 (18%), Positives = 104/323 (32%), Gaps = 37/323 (11%)

Query: 54   SPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQN--------PPATVV 105
            +P P P    +P       + + +    TPT   +  P  T +           P  T  
Sbjct: 4001 TPTPTPTGTQTPTTTP---ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 4057

Query: 106  PQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPAT 165
            P + P+++     +    P+    P + P T      P       +  T      +TP T
Sbjct: 4058 PTTTPITTTT-TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT------TTPIT 4110

Query: 166  TTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEV 225
            TT+T +   T   +  P  +   +++ +      T   +            TPT   +  
Sbjct: 4111 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 4170

Query: 226  HFTLAKP---PSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSP 282
                  P    + V  T  P G Q  G  +    +P+ E              + P  S 
Sbjct: 4171 QTPTTTPITTTTTVTPTPTPTGTQT-GPPTHTSTAPIAELT----------TSNPPPESS 4219

Query: 283  RPQRHIMSRSPMVERR-MMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYS 341
             PQ    + SP+ E   ++    PA E       TAPP+     +T      +  PPS +
Sbjct: 4220 TPQTSRSTSSPLTESTTLLSTLPPAIEMTS----TAPPSTPTAPTTTSGGHTLSPPPSTT 4275

Query: 342  VLYPSSDPKSSHLKGQAVPASKT 364
               P +  + +     + P   T
Sbjct: 4276 TSPPGTPTRGTTTGSSSAPTPST 4298



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 43/194 (22%), Positives = 69/194 (35%), Gaps = 31/194 (15%)

Query: 491  MEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPART----------- 539
            M+K +   S  T   +  P+ T +LP     PT  P      + +P  T           
Sbjct: 1392 MDKCITTPSPPTTTPSPPPTSTTTLP-----PTTTPSPPTTTTTTPPPTTTPSPPITTTT 1446

Query: 540  --PPASLYHGYLPENGVLRPEPTKQPPYQL-RPSLFVLSPIKEPAKVSPRAASPAKPSSL 596
              PP +     +       P  T  PP     P     SP        P   +P+ P++ 
Sbjct: 1447 TPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTT 1506

Query: 597  DLVPNLPKGALPPS--PALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAW 654
             + P      LPP+  P+ P  + ++P   T+P          SPP    I+P + +   
Sbjct: 1507 PITPPASTTTLPPTTTPSPPTTTTTTPPPTTTP----------SPPTTTPITPPTSTTTL 1556

Query: 655  SPRAKQAPRPSFST 668
             P    +P P+ +T
Sbjct: 1557 PPTTTPSPPPTTTT 1570



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 85/450 (18%), Positives = 125/450 (27%), Gaps = 86/450 (19%)

Query: 218  PTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMER------SPMLERRHFGEKAPA 271
            PT   +    T   PP+    T  P    +P  T+          SP +           
Sbjct: 1410 PTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTTTTPPPTTT 1469

Query: 272  PQPP----SLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLST 327
            P PP    S P  +P P     +  P          +P +   P    T PPT   T  +
Sbjct: 1470 PSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITP--PASTTTLPPT---TTPS 1524

Query: 328  APLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKP 387
             P  +    PP+ +   P++ P +       +P + T           S     T    P
Sbjct: 1525 PPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTP----------SPPPTTTTTPPP 1574

Query: 388  KVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEE 447
              TP+P                          P    +  +     P P    SP     
Sbjct: 1575 TTTPSPPTTTTPSPPTITT---------TTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTP 1625

Query: 448  VVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELAR 507
            + P  ++    P     P P                              +++ TP    
Sbjct: 1626 ITPPTSTTTLPPTTTPSPPP------------------------------TTTTTPPPTT 1655

Query: 508  CPSP-TMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQ 566
             PSP T + PS     T  P      S SP  T P+       P   +  P PT  P   
Sbjct: 1656 TPSPPTTTTPSPPITTTTTPPPTTTPS-SPITTTPSP------PTTTMTTPSPTTTP--- 1705

Query: 567  LRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTS 626
                         P   +   +S   PS        P     PSP     +   P   +S
Sbjct: 1706 -----------SSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSS 1754

Query: 627  PGQDSLQPTAVSPPYGGDISPVSPSRAWSP 656
            P   +  P +++PP     S  +P+    P
Sbjct: 1755 PLTTTPLPPSITPPTFSPFSTTTPTTPCVP 1784



 Score = 33.9 bits (76), Expect = 0.51
 Identities = 36/167 (21%), Positives = 60/167 (35%), Gaps = 24/167 (14%)

Query: 509  PSPTMSLPSSWKYPTNAPGAFRVASRSPARTP-PASLYHGYLPENGVLRPEPTKQPPYQL 567
            P+ T +LP +    T +P      +  P  TP P +      P      P PT  P    
Sbjct: 1550 PTSTTTLPPT---TTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTP---- 1602

Query: 568  RPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPS--PALPRPSRSSPGLYT 625
                   SP        P   +P+ P++  + P      LPP+  P+ P  + ++P   T
Sbjct: 1603 -------SPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTT 1655

Query: 626  SPGQDS-------LQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPS 665
            +P   +       +  T   PP     SP++ + +        P P+
Sbjct: 1656 TPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPT 1702



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 45/176 (25%), Positives = 57/176 (32%), Gaps = 22/176 (12%)

Query: 502  TPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPAR--TPPASLYHGYLPENGVLRPEP 559
            TP  +    P  + PS     T  P      S       TPP S     LP      P P
Sbjct: 1509 TPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTT--LPPTTTPSPPP 1566

Query: 560  TKQ--PPYQLRPS---LFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALP 614
            T    PP    PS       SP        P   +P+ P++            PP    P
Sbjct: 1567 TTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTT--------TTPPPTTTP 1618

Query: 615  RPSRSSPGLYTSPGQDSLQP--TAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFST 668
             P  ++P   T P   +  P  T  SPP     +P  P+   SP     P P  +T
Sbjct: 1619 SPPTTTP--ITPPTSTTTLPPTTTPSPPPTTTTTP-PPTTTPSPPTTTTPSPPITT 1671


>gi|239755545 PREDICTED: otogelin isoform 1 [Homo sapiens]
          Length = 2852

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 107/418 (25%), Positives = 155/418 (37%), Gaps = 99/418 (23%)

Query: 33   NAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPP 92
            N  L  + GL    + E Q S  +P     H PA        +P+A LTT       NPP
Sbjct: 1405 NETLPPSQGLPTPSDEEPQLSQESPR-TPTHRPAL-------TPAAPLTTAL-----NPP 1451

Query: 93   ATD-----VNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGT-GPASK---PSTLCADGQP 143
             T      V+  P  T + Q L L++       +QLP+  T  PASK    S L     P
Sbjct: 1452 VTATEEPVVSPGPTQTTLQQPLELTA-------SQLPAGPTESPASKGVTASLLAIPHTP 1504

Query: 144  QAPAEEVRCSTLLIDKVSTPATTTST---FSREATLIPSSR-PPASDFMSSSLLIDI--- 196
            ++ +  V   T     VS    TT     F+    +  SSR PPA  F   +  + +   
Sbjct: 1505 ESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPLMTKAVTVRGH 1564

Query: 197  ----------QPN-TLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGI 245
                      QP+ T   S+    S  A + +PT   S           V++RT  P   
Sbjct: 1565 GSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPT 1624

Query: 246  QAPGGTS-------------QMERSPML----------ERRHFGEKAP-----APQPPSL 277
            QA   +S             Q+  SP+           E+   G   P     +PQP  L
Sbjct: 1625 QAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPL 1684

Query: 278  PDRSPRPQRH--IMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVR 335
            P   PRP +H  + +RSP      +   +PA+         +  T T+ L+  P  S   
Sbjct: 1685 PSAPPRPAQHTTMATRSP-----ALPPETPAA--------ASLSTATDGLAATPFMSLES 1731

Query: 336  SPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNP 393
            + PS   L     P +S      +P +K G     +A  G + S+ T   +P+ T  P
Sbjct: 1732 TRPSQ--LLSGLPPDTS------LPLAKVG-TSAPVATPGPKASVITTPLQPQATTLP 1780



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 46/186 (24%), Positives = 68/186 (36%), Gaps = 20/186 (10%)

Query: 499  SSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGV-LRP 557
            + HT    R P+     P++    T   G       S   T P+ L  G  P+  + L  
Sbjct: 1692 AQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAK 1751

Query: 558  EPTKQPPYQLRPSLFVL-SPIKEPAKVSP-RAASPAKPSSLDLVPNLPKGALPPSPALPR 615
              T  P     P   V+ +P++  A   P +  SP  P      P     A PP+   P 
Sbjct: 1752 VGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLP----FTPAAMTQAHPPTHIAPP 1807

Query: 616  PSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEA 675
             + ++PGL       +L  + V P   G  S VS            PR S + + A +  
Sbjct: 1808 AAGTAPGLLLGA---TLPTSGVLPVAEGTASMVS----------VVPRKSTTGKVAILSK 1854

Query: 676  QVWKPS 681
            QV  P+
Sbjct: 1855 QVSLPT 1860


>gi|239755543 PREDICTED: otogelin isoform 2 [Homo sapiens]
          Length = 2924

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 107/418 (25%), Positives = 155/418 (37%), Gaps = 99/418 (23%)

Query: 33   NAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPP 92
            N  L  + GL    + E Q S  +P     H PA        +P+A LTT       NPP
Sbjct: 1477 NETLPPSQGLPTPSDEEPQLSQESPR-TPTHRPAL-------TPAAPLTTAL-----NPP 1523

Query: 93   ATD-----VNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGT-GPASK---PSTLCADGQP 143
             T      V+  P  T + Q L L++       +QLP+  T  PASK    S L     P
Sbjct: 1524 VTATEEPVVSPGPTQTTLQQPLELTA-------SQLPAGPTESPASKGVTASLLAIPHTP 1576

Query: 144  QAPAEEVRCSTLLIDKVSTPATTTST---FSREATLIPSSR-PPASDFMSSSLLIDI--- 196
            ++ +  V   T     VS    TT     F+    +  SSR PPA  F   +  + +   
Sbjct: 1577 ESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPLMTKAVTVRGH 1636

Query: 197  ----------QPN-TLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGI 245
                      QP+ T   S+    S  A + +PT   S           V++RT  P   
Sbjct: 1637 GSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPT 1696

Query: 246  QAPGGTS-------------QMERSPML----------ERRHFGEKAP-----APQPPSL 277
            QA   +S             Q+  SP+           E+   G   P     +PQP  L
Sbjct: 1697 QAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPL 1756

Query: 278  PDRSPRPQRH--IMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVR 335
            P   PRP +H  + +RSP      +   +PA+         +  T T+ L+  P  S   
Sbjct: 1757 PSAPPRPAQHTTMATRSP-----ALPPETPAA--------ASLSTATDGLAATPFMSLES 1803

Query: 336  SPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNP 393
            + PS   L     P +S      +P +K G     +A  G + S+ T   +P+ T  P
Sbjct: 1804 TRPSQ--LLSGLPPDTS------LPLAKVG-TSAPVATPGPKASVITTPLQPQATTLP 1852



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 46/186 (24%), Positives = 68/186 (36%), Gaps = 20/186 (10%)

Query: 499  SSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGV-LRP 557
            + HT    R P+     P++    T   G       S   T P+ L  G  P+  + L  
Sbjct: 1764 AQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAK 1823

Query: 558  EPTKQPPYQLRPSLFVL-SPIKEPAKVSP-RAASPAKPSSLDLVPNLPKGALPPSPALPR 615
              T  P     P   V+ +P++  A   P +  SP  P      P     A PP+   P 
Sbjct: 1824 VGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLP----FTPAAMTQAHPPTHIAPP 1879

Query: 616  PSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEA 675
             + ++PGL       +L  + V P   G  S VS            PR S + + A +  
Sbjct: 1880 AAGTAPGLLLGA---TLPTSGVLPVAEGTASMVS----------VVPRKSTTGKVAILSK 1926

Query: 676  QVWKPS 681
            QV  P+
Sbjct: 1927 QVSLPT 1932


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.125    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,853,639
Number of Sequences: 37866
Number of extensions: 2207401
Number of successful extensions: 15425
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 118
Number of HSP's successfully gapped in prelim test: 1100
Number of HSP's that attempted gapping in prelim test: 10736
Number of HSP's gapped (non-prelim): 4731
length of query: 685
length of database: 18,247,518
effective HSP length: 109
effective length of query: 576
effective length of database: 14,120,124
effective search space: 8133191424
effective search space used: 8133191424
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.