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Search of human proteins with 157909822
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157909822 pragmin [Homo sapiens]
(1402 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157909822 pragmin [Homo sapiens] 2900 0.0
gi|148368962 NKF3 kinase family member [Homo sapiens] 417 e-116
gi|38348368 hypothetical protein LOC374872 [Homo sapiens] 100 1e-20
gi|163965366 nascent polypeptide-associated complex alpha subuni... 73 2e-12
gi|14165272 PTEN induced putative kinase 1 precursor [Homo sapiens] 61 7e-09
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 60 1e-08
gi|188536004 zinc finger protein 469 [Homo sapiens] 59 3e-08
gi|110832843 TBP-associated factor 4 [Homo sapiens] 57 1e-07
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 56 3e-07
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 52 3e-06
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 52 4e-06
gi|239743293 PREDICTED: mucin 12 [Homo sapiens] 50 1e-05
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 50 2e-05
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 50 2e-05
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 50 2e-05
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 50 2e-05
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 50 2e-05
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 50 2e-05
gi|21264565 AT rich interactive domain 1A isoform a [Homo sapiens] 50 2e-05
gi|21264575 AT rich interactive domain 1A isoform b [Homo sapiens] 50 2e-05
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 49 3e-05
gi|239508976 PREDICTED: mucin 12, cell surface associated [Homo ... 49 3e-05
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 49 3e-05
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 49 3e-05
gi|150170670 piccolo isoform 2 [Homo sapiens] 49 4e-05
gi|150378539 piccolo isoform 1 [Homo sapiens] 49 4e-05
gi|148727255 microtubule associated serine/threonine kinase fami... 49 4e-05
gi|7657387 CCR4-NOT transcription complex, subunit 3 [Homo sapiens] 49 4e-05
gi|150378545 POM121 membrane glycoprotein (rat)-like [Homo sapiens] 48 6e-05
gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens] 48 8e-05
>gi|157909822 pragmin [Homo sapiens]
Length = 1402
Score = 2900 bits (7518), Expect = 0.0
Identities = 1402/1402 (100%), Positives = 1402/1402 (100%)
Query: 1 MHQTLCLNPESLKMSACSDFVEHIWKPGSCKNCFCLRSDHQLVAGPPQPRAGSLPPPPRL 60
MHQTLCLNPESLKMSACSDFVEHIWKPGSCKNCFCLRSDHQLVAGPPQPRAGSLPPPPRL
Sbjct: 1 MHQTLCLNPESLKMSACSDFVEHIWKPGSCKNCFCLRSDHQLVAGPPQPRAGSLPPPPRL 60
Query: 61 PPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSSEASDVWTEANLSAEVSQVIWRRAPGKL 120
PPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSSEASDVWTEANLSAEVSQVIWRRAPGKL
Sbjct: 61 PPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSSEASDVWTEANLSAEVSQVIWRRAPGKL 120
Query: 121 PLPKQEDAPVVYLGSFRGVQKPAGPSTSPDGNSRCPPAYTMVGLHNLEPRGERNIAFHPV 180
PLPKQEDAPVVYLGSFRGVQKPAGPSTSPDGNSRCPPAYTMVGLHNLEPRGERNIAFHPV
Sbjct: 121 PLPKQEDAPVVYLGSFRGVQKPAGPSTSPDGNSRCPPAYTMVGLHNLEPRGERNIAFHPV 180
Query: 181 SFPEEKAVHKEKPSFPYQDRPSTQESFRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQ 240
SFPEEKAVHKEKPSFPYQDRPSTQESFRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQ
Sbjct: 181 SFPEEKAVHKEKPSFPYQDRPSTQESFRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQ 240
Query: 241 RCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQ 300
RCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQ
Sbjct: 241 RCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQ 300
Query: 301 EKRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLE 360
EKRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLE
Sbjct: 301 EKRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLE 360
Query: 361 SDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKA 420
SDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKA
Sbjct: 361 SDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKA 420
Query: 421 APVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPE 480
APVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPE
Sbjct: 421 APVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPE 480
Query: 481 EDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERP 540
EDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERP
Sbjct: 481 EDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERP 540
Query: 541 AIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAPSCRTN 600
AIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAPSCRTN
Sbjct: 541 AIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAPSCRTN 600
Query: 601 GVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGP 660
GVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGP
Sbjct: 601 GVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGP 660
Query: 661 TDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAFEFPKDRSGIETFSPPPPPPKSRH 720
TDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAFEFPKDRSGIETFSPPPPPPKSRH
Sbjct: 661 TDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAFEFPKDRSGIETFSPPPPPPKSRH 720
Query: 721 LLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGSTDSLASDSRTCSDGGPSSELAHS 780
LLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGSTDSLASDSRTCSDGGPSSELAHS
Sbjct: 721 LLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGSTDSLASDSRTCSDGGPSSELAHS 780
Query: 781 PTNSGKKLFAPVPFPSGSTEDVSPSGPQQPPPLPQKKIVSRAASSPDGFFWTQGSPKPGT 840
PTNSGKKLFAPVPFPSGSTEDVSPSGPQQPPPLPQKKIVSRAASSPDGFFWTQGSPKPGT
Sbjct: 781 PTNSGKKLFAPVPFPSGSTEDVSPSGPQQPPPLPQKKIVSRAASSPDGFFWTQGSPKPGT 840
Query: 841 ASPKLNLSHSETNVHDESHFSYSLSPGNRHHPVFSSSDPLEKAFKGSGHWLPAAGLAGNR 900
ASPKLNLSHSETNVHDESHFSYSLSPGNRHHPVFSSSDPLEKAFKGSGHWLPAAGLAGNR
Sbjct: 841 ASPKLNLSHSETNVHDESHFSYSLSPGNRHHPVFSSSDPLEKAFKGSGHWLPAAGLAGNR 900
Query: 901 GGCGSPGLQCKGAPSASSSQLSVSSQASTGSTQLQLHGLLSNISSKEGTYAKLGGLYTQS 960
GGCGSPGLQCKGAPSASSSQLSVSSQASTGSTQLQLHGLLSNISSKEGTYAKLGGLYTQS
Sbjct: 901 GGCGSPGLQCKGAPSASSSQLSVSSQASTGSTQLQLHGLLSNISSKEGTYAKLGGLYTQS 960
Query: 961 LARLVAKCEDLFMGGQKKELHFNENNWSLFKLTCNKPCCDSGDAIYYCATCSEDPGSTYA 1020
LARLVAKCEDLFMGGQKKELHFNENNWSLFKLTCNKPCCDSGDAIYYCATCSEDPGSTYA
Sbjct: 961 LARLVAKCEDLFMGGQKKELHFNENNWSLFKLTCNKPCCDSGDAIYYCATCSEDPGSTYA 1020
Query: 1021 VKICKAPEPKTVSYCSPSVPVHFNIQQDCGHFVASVPSSMLSSPDAPKDPVPALPTHPPA 1080
VKICKAPEPKTVSYCSPSVPVHFNIQQDCGHFVASVPSSMLSSPDAPKDPVPALPTHPPA
Sbjct: 1021 VKICKAPEPKTVSYCSPSVPVHFNIQQDCGHFVASVPSSMLSSPDAPKDPVPALPTHPPA 1080
Query: 1081 QEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGII 1140
QEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGII
Sbjct: 1081 QEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGII 1140
Query: 1141 HRDLCLENLLLVHCTLQAGPGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGP 1200
HRDLCLENLLLVHCTLQAGPGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGP
Sbjct: 1141 HRDLCLENLLLVHCTLQAGPGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGP 1200
Query: 1201 REKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSASQYRKFDEFQTGILIYEL 1260
REKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSASQYRKFDEFQTGILIYEL
Sbjct: 1201 REKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSASQYRKFDEFQTGILIYEL 1260
Query: 1261 LHQPNPFEVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKRV 1320
LHQPNPFEVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKRV
Sbjct: 1261 LHQPNPFEVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKRV 1320
Query: 1321 LQCLLWGPRRELVQQPGTSEEALCGTLHNWIDMKRALMMMKFAEKAVDRRRGVELEDWLC 1380
LQCLLWGPRRELVQQPGTSEEALCGTLHNWIDMKRALMMMKFAEKAVDRRRGVELEDWLC
Sbjct: 1321 LQCLLWGPRRELVQQPGTSEEALCGTLHNWIDMKRALMMMKFAEKAVDRRRGVELEDWLC 1380
Query: 1381 CQYLASAEPGALLQSLKLLQLL 1402
CQYLASAEPGALLQSLKLLQLL
Sbjct: 1381 CQYLASAEPGALLQSLKLLQLL 1402
>gi|148368962 NKF3 kinase family member [Homo sapiens]
Length = 1746
Score = 417 bits (1073), Expect = e-116
Identities = 355/1089 (32%), Positives = 496/1089 (45%), Gaps = 155/1089 (14%)
Query: 406 QPEPIYAESTKRKKAAPVPSKSQ---AKIEHAAAAQGQGQVCT----GNAWAQKAASGWG 458
Q P + S+ A + +Q AKIE +Q G T +Q AS
Sbjct: 717 QSSPQRSYSSSHSSPAKIQRATQEPVAKIEGTQESQMVGSSSTREKASTVLSQIVASIQP 776
Query: 459 RDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRG-PVSQNSEVGEEETSA 517
SP TPQ A EE +Y PD+ V P+ PV S + +
Sbjct: 777 PQSPPETPQSGPK----ACSVEE----LYAIPPDADVAKSTPKSTPVRPKSLFTSQPSGE 828
Query: 518 GQGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVS-PSAGGPPVSPLADLSDGSS 576
+ + +S + P +P P S S V SP S P A PP P + S +
Sbjct: 829 AEAPQTTDSPTTKVQKD-PSIKPVTP---SPSKLVTSPQSEPPAPFPP--PRSTSSPYHA 882
Query: 577 GGSSIGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCR 636
G P P S V S+ SR A+ A +R F++ R+
Sbjct: 883 GNLLQRHFTNWTKPTSPTRSTEAESVLHSEGSR----RAADAKPKRWISFKSFFRRRKTD 938
Query: 637 IEEEEEVEQE-------------------LLSHSWGRETKNGPTDHSNSTTWHRLHPTDG 677
E+++E E+E + H W E K ++ +R P G
Sbjct: 939 EEDDKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGESSEKPAIVFMYRCDPAQG 998
Query: 678 S-SGQNSKVGTGMS---KSASFAFEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEK 733
S SK T + + +D + S P PK ++ + D
Sbjct: 999 QLSVDQSKARTDQAAVMEKGRAENALLQDSEKKRSHSSPSQIPKKILSHMTHEVTEDFSP 1058
Query: 734 VSQGSAESLSPSFRGVHVSFTTGSTDSLASDS--RTCSDGGPSSELAHSPTNSGKKLFAP 791
+ RG T S L + SD + + + +N G+ A
Sbjct: 1059 RDPRTVVGKQDG-RGCTSVTTALSLPELEREDGKEDISDPMDPNPCSATYSNLGQSRAAM 1117
Query: 792 VP-----FPSGSTEDV----------SPSGPQQ-PPPLPQKKIVSRAASSP--DGFFWTQ 833
+P P G+ +D +P+ Q PPPLP KK++ RA + P +
Sbjct: 1118 IPPKQPRQPKGAVDDAIAFGGKTDQEAPNASQPTPPPLP-KKMIIRANTEPISKDLQKSM 1176
Query: 834 GSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHHPVFSSSDPLEKAFKGSGHWLPA 893
S A+P ++ + S SY L + S D LE+ + P
Sbjct: 1177 ESSLCVMANPTYDIDPNWDASSAGSSISYELKGLD-----IESYDSLERPLRKE---RPV 1228
Query: 894 AGLAGNRGGCGSPGLQCKGAPS--ASSSQLSVSSQASTGSTQLQLHGLLSNISSKEGTYA 951
A + + ++ + + S + SS+ S + G + Q L + ++E
Sbjct: 1229 PSAANSISSLTTLSIKDRFSNSMESLSSRRGPSCRQGRGIQKPQRQALYRGLENREEVVG 1288
Query: 952 KLGGLYTQSLARLVAKCEDLFMGGQKKELHFNENNWSLFKLTCNKPCCDSGDAIYYCATC 1011
K+ L+T +L +L KCEDLFM GQK +L F ++WS F+LT +KPCC++GDA+YY A+
Sbjct: 1289 KIRSLHTDALKKLAVKCEDLFMAGQKDQLRFGVDSWSDFRLTSDKPCCEAGDAVYYTASY 1348
Query: 1012 SEDPGSTYAVKICKAPEPKTVSY-----CSPSVPVHFNIQQDCGHFVASVPSSML--SSP 1064
++DP + YAVKICK+ ++ Y S+ VHFNIQQDCGHF+A VP+ +L P
Sbjct: 1349 AKDPLNNYAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDP 1408
Query: 1065 DAP--------------------KDPVPALPTHPPAQE---------QDCVVVITREVPH 1095
D P K+P P +E + VVVITREVP
Sbjct: 1409 DDPEKDEDDMEETEEDAKGETDGKNPKPCSEAASSQKENQGVMSKKQRSHVVVITREVPC 1468
Query: 1096 QTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCT 1155
T +DFVRDS A H P+ YER+VC LLLQLC+GLEHLK + + H DL LENLLLVH
Sbjct: 1469 LTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHY- 1527
Query: 1156 LQAGPGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLK 1215
GGT + GPA P P RLI+SNF +
Sbjct: 1528 ---------------------------QPGGT-AQGFGPAEP-SPTSSYPTRLIVSNFSQ 1558
Query: 1216 AKQKPGGTPNLQQKKSQARLAPEIVSASQYRKFDEFQTGILIYELLHQPNPFEVRAQLRE 1275
AKQK + + + Q+RLAPEI++A+QY+K DEFQTGILIYE+LH PNPF+ +L+E
Sbjct: 1559 AKQK-SHLVDPEILRDQSRLAPEIITATQYKKCDEFQTGILIYEMLHLPNPFDENPELKE 1617
Query: 1276 RDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCLLWGPRRELVQQ 1335
R+Y + DLP +P S YS GLQQLA LL +P +RI I +AK +LQCLLWGPR +L Q
Sbjct: 1618 REYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSERILISDAKGILQCLLWGPREDLFQT 1677
Query: 1336 ----PGTSEEALCGTLHNWIDMKRALMMMKFAEKAVDRRRGVELEDWLCCQYLASAEPGA 1391
P + L NW+D+KR L+M+KFAEK++DR G+ LEDWLC QYLA A +
Sbjct: 1678 FTACPSLVQRNT--LLQNWLDIKRTLLMIKFAEKSLDREGGISLEDWLCAQYLAFATTDS 1735
Query: 1392 LLQSLKLLQ 1400
L +K+LQ
Sbjct: 1736 LSCIVKILQ 1744
Score = 67.4 bits (163), Expect = 9e-11
Identities = 38/94 (40%), Positives = 51/94 (54%), Gaps = 6/94 (6%)
Query: 14 MSACSDFVEHIWKPGSCKNCFCLRSDHQLVAGPPQPRAGSLP--PPPRLPPRPENCRLED 71
MSAC+ F EH+WKPG CKNCF +S HQL PP P + N R+ +
Sbjct: 1 MSACNTFTEHVWKPGECKNCFKPKSLHQL---PPDPEKAPITHGNVKTNANHSNNHRIRN 57
Query: 72 EGVNSSPYS-KPTIAVKPTMMSSEASDVWTEANL 104
G P + KPTIAVKPTM+ ++ + E ++
Sbjct: 58 TGNFRPPVAKKPTIAVKPTMIVADGQSICGELSI 91
>gi|38348368 hypothetical protein LOC374872 [Homo sapiens]
Length = 473
Score = 100 bits (249), Expect = 1e-20
Identities = 128/498 (25%), Positives = 182/498 (36%), Gaps = 128/498 (25%)
Query: 912 GAPSASSSQLSVS-----SQASTGSTQLQLHGLLSNISSKEGTYAKLGGLYTQSLARLVA 966
G+ S SQ +V ++ + G L L ++ S E + L Q L + A
Sbjct: 92 GSHSVDKSQAAVGPACLPAELTFGPADAPLGLSLRDLHSPEAVHTALAARQLQGLRTIYA 151
Query: 967 KCEDLFMGGQKKELHFNENNWSLFKLTCNKPCCDSGDAIYY-CATCSEDPGSTYAVKICK 1025
+ MGG H + F+L + PC +SGDA+YY ED K+ K
Sbjct: 152 RLRARLMGGHPGPCHPGHS----FRLLDSSPCAESGDALYYRVVRAHEDAWHILVAKVPK 207
Query: 1026 ----APEPKTVSYCSPSVPVHFNIQQDCGHFVASVPSSMLSSPDAPKDPVPALPTHPPAQ 1081
P P + S+ HFN+Q CG P+ +P P
Sbjct: 208 PGADVPHPWGLE-LQASLSPHFNLQGLCGL--------------VPEGTLPGAPWRG--- 249
Query: 1082 EQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIH 1141
V + EVP +T + ++ ++ PE + V LLLQL L+ L+ G
Sbjct: 250 ----AVALAAEVPERTVAQWLAEACTQ---PPEEFVWAVALLLLQLSAALKFLEAWGAAL 302
Query: 1142 RDLCLENLLLVHCTLQAGPGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGPR 1201
+L ENLLLV AP A P
Sbjct: 303 VELRPENLLLV--------------APRGCATTGP------------------------- 323
Query: 1202 EKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSASQYRKFDEFQTGILIYELL 1261
PRL++++F + +P G P S AP Q G L+ LL
Sbjct: 324 ----PRLLLTDFGRVCLQPPGPPG-----SPGPHAP--------------QLGSLLRALL 360
Query: 1262 HQPNPFEVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVL 1321
P PL A GL+ LA L P + L
Sbjct: 361 SLAAP---------------STTPLAA------GLELLAAQLTRLRP----SASRTRGAL 395
Query: 1322 QCLLWGPRRELVQQPGTSEEALCGTLHNWIDMKRALMMMKFAEKAVDRRRGVELEDWLCC 1381
Q LLWGP EL + G L W+ ++R L++++ AE+A LEDWLCC
Sbjct: 396 QALLWGPGPEL-RGRGAPLGPWLRALGPWLRVRRGLLVLRLAERAAG-GEAPSLEDWLCC 453
Query: 1382 QYLASAEPGALLQSLKLL 1399
+YLA A ++ Q+L LL
Sbjct: 454 EYLAEATESSMGQALALL 471
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 72.8 bits (177), Expect = 2e-12
Identities = 198/895 (22%), Positives = 283/895 (31%), Gaps = 165/895 (18%)
Query: 42 LVAGPPQPRAGSLP--PPPRLPP-------------------RPENCRLEDEGVNSSPYS 80
LV P P++ P PP PP P+ C ED G +++ S
Sbjct: 724 LVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASS 783
Query: 81 KPTIAV------------------KPTMMSSEASDVWTEANLSAEVSQVIWRRAP-GKLP 121
K T+ PT S D NLS+ VS V P L
Sbjct: 784 KGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDT-PIGNLSSPVSPVEASFLPENSLS 842
Query: 122 LPKQEDAPVVYLGSFRGVQKPAGPSTSPDGNSRCPPAYTMVGLHNLEPRGERNIAFHPVS 181
+D+P P PS P G A T + L P+G + P
Sbjct: 843 FQGSKDSPAT-------THSPTPPS--PKG------APTPSAVTPLSPKG---VTLPPKE 884
Query: 182 FPEEKAVH----KEKPSFPY--QDRPSTQESFRQKLAAFAGTTSGCHQGPGPLRESLPSE 235
P V+ KE P+ P Q + S K A G P P P
Sbjct: 885 TPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPP- 943
Query: 236 DDSDQRCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAG-SRGRHGGRDCSPTCWEQGKC 294
+ +GG P P A S G + G P
Sbjct: 944 ------AATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPK 997
Query: 295 SGPAEQEKRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSP 354
GPA +G P P P+ K + T AA S GS A++P
Sbjct: 998 GGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPP------SPKGSPAATP 1051
Query: 355 FVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAES 414
+ + + P G P TPS L G P PPA AT P P +
Sbjct: 1052 LPKGAPTTPAATLPSPK-------GGPA-TPS----LKGAPTPPA----ATPPSPKGGPA 1095
Query: 415 TKRKKAAPVPSKSQAKIEHAAAAQG--QGQVCTGNAWAQKAASGWGRDSPDPTPQVSATI 472
T K AP+P + A +G T A G P P A
Sbjct: 1096 TPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAAT 1155
Query: 473 TV-----MAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESH 527
+A P + T ++P S P+G ++ S G T A S +
Sbjct: 1156 PPSPKGGLATPPPKGAPTTPAATPPS------PKGGLATPSPKGAPTTPAATPPSPKGGL 1209
Query: 528 AHSASESKPKERPAIPPK----LSKSSPVGSPVSPSA------GGPPV-------SPLAD 570
A + + P A PP L+ SP G+P +P+A GGP +P A
Sbjct: 1210 ATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAA 1269
Query: 571 LSDGSSGGSSIGPQPPSQGPADPAPSCRTNGVAISDPSRCPQP-AASSASEQRRPRFQAG 629
GG + P + PA P G A S P P P AA+ S + P
Sbjct: 1270 TPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPP 1329
Query: 630 TWSRQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGM 689
+ + + +K GPT S+ PT ++ + K G M
Sbjct: 1330 KGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEG-----PTPPAATPSHKGGPAM 1384
Query: 690 SKSASFAFEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLS------ 743
+ + PK I + P P S ++ ++ + V++ A + S
Sbjct: 1385 TPPS------PKRGPAIPS---PKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTP 1435
Query: 744 PSFRGVHVSFTTGSTDSLASDSRTCSDGGPSSELAHSP------------TNSGKKLFAP 791
P+ V + ++ + S G P+ P T+S K
Sbjct: 1436 PAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPA 1495
Query: 792 VPFPSGSTE--DVSPSGPQQPPPLPQKKIVSRAASSPDGFFWTQGSPKPGTASPK 844
P P G+ V PS P++ P P + R +P ++ + P T +PK
Sbjct: 1496 TPAPMGAPTLPAVIPSSPKEVPATPSSR---RDPIAPTATLLSKKT--PATLAPK 1545
Score = 51.2 bits (121), Expect = 7e-06
Identities = 136/606 (22%), Positives = 190/606 (31%), Gaps = 134/606 (22%)
Query: 44 AGPPQPRAGSLPPPPR-LPPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSSEASDVWTEA 102
A PP P+ G PPP+ P P +G ++P K S + T +
Sbjct: 1154 ATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPS 1213
Query: 103 NLSAEVSQVIWRRAP-GKLPLPKQEDAPVVYLGSFRGVQKPAGPSTSPDGNSRCPPAYTM 161
A + +P G L P + AP + GP+T P + PPA T
Sbjct: 1214 PKGAPTTPAATPPSPKGGLATPSPKGAPTTPAAT--PPSPKGGPATPPPKGAPTPPAATP 1271
Query: 162 V----GLHNLEPRGERNIAFHPVSFPE---EKAVHKEKPSFPYQDRPSTQESFRQKLAAF 214
GL +G N A P+ + K P+ P PS + S
Sbjct: 1272 PSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGS-------- 1323
Query: 215 AGTTSGCHQGPGPLRESLPSEDDSDQRCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAG 274
T P P + PS + + + S+GG P +P +K
Sbjct: 1324 -PGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGG---------PTTPSSKEGPTPPA 1373
Query: 275 SRGRHGGRDCSPTCWEQGKCSGPA---EQEKRGPSFPKECCSQGPTAHPSC--LGPKKLS 329
+ H G GPA KRGP+ P +G P+ L PKK
Sbjct: 1374 ATPSHKG--------------GPAMTPPSPKRGPAIPSP---KGDPTSPAVIPLSPKKAP 1416
Query: 330 LTSEAAISSDGLSCGSGSGSGASSPFVPHLESDYCSLMKEPA----------PEKQQDPG 379
T ++ +G + + S + P V + SL K PA P + DP
Sbjct: 1417 ATP---VTREGAA--TPSKGDLTPPAVTPV-----SLKKAPATSAPKGGPATPSSKGDPT 1466
Query: 380 CPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQG 439
P VTP +PPA + AT P KKA P+ A A
Sbjct: 1467 LPAVTPP------SPKEPPAPKQVATSSSP--------KKAPATPAPMGAPTLPAVIPSS 1512
Query: 440 QGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQW 499
+V A RD PT + + T P+E L P V
Sbjct: 1513 PKEV--------PATPSSRRDPIAPTATLLSKKTPATLAPKEA-----LIPPAMTV---- 1555
Query: 500 PRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPS 559
S + + PKE PA P SSP S
Sbjct: 1556 -------------------------PSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTY 1590
Query: 560 AGGPPVSPLADLSDGSSGGSSIGPQPPS-------QGPADPAPSCRTNGVAISDPSRCPQ 612
G P L +S P PP+ +GPA PAP ++ S
Sbjct: 1591 KGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDS 1650
Query: 613 PAASSA 618
P + ++
Sbjct: 1651 PTSPAS 1656
Score = 50.8 bits (120), Expect = 9e-06
Identities = 215/959 (22%), Positives = 316/959 (32%), Gaps = 164/959 (17%)
Query: 47 PQPRAGSLPPPPRLPPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSSEASDVWTEANLSA 106
P P+ G+ PP + P +C + S S P PT + AS + +S
Sbjct: 197 PNPK-GTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTT--PTTTLAIASPQVKDTTIS- 252
Query: 107 EVSQVIWRRAPGKLPLPKQEDAPVVYLGSFRGV------QKPAGPSTSPD-----GNSRC 155
S +I + PG L L P S + + QK AGP+T PD G+
Sbjct: 253 --SVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLA 310
Query: 156 PPAYTMVGLHNLEPRGERNIAFHPVSFPEEKAVHKEKPS----FPYQDR-----PSTQES 206
P + G +++ G+ + +S P K + + S +P Q PS E
Sbjct: 311 PLHQSSFG--SVQLLGQTGPS--ALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEV 366
Query: 207 FRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQRCSPSGDSEGGEYCS-------ILDC 259
+AAF +GP + S CSPSG S IL
Sbjct: 367 VPATVAAFPVVAPSVDKGPSTI---------SSITCSPSGSLNVATSFSLSPTTSLILKS 417
Query: 260 CPGSP-----VAKAASQTAGSRGRHGGRDCS-----------PTCWEQGKCSGPAEQEK- 302
P + VA+ + G+ C+ TC SGP +
Sbjct: 418 SPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEP 477
Query: 303 -------RGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPF 355
P PKE +Q T + P + S L P
Sbjct: 478 TSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVL---------VKFPT 528
Query: 356 VPHLESDYCSLMKEPAPEKQQDPGC-----PGVTPSRCLGLTGEPQPPAHPREATQPE-P 409
L++ SL E AP G P V P L P+ ++ PE P
Sbjct: 529 QKDLQTVPASL--EGAPFSPAQAGLTTKKDPTVLP---LVQAAPKNSPSFQSTSSSPEIP 583
Query: 410 IYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRDSPDPTPQVS 469
+ E+T KK+ P I A++ +A K S G DS P + S
Sbjct: 584 LSPEATLAKKSLGEP----LPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSS 639
Query: 470 ATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSE----VGEEETSAGQGLSSRE 525
+AA P E ++ P +A G S E + + +G +
Sbjct: 640 LITPTVAAFPLESADPAGVA-PTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTL 698
Query: 526 SHAHSASES-----------KPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDG 574
+ASE+ P + P++ KS P SP P AG PP + D G
Sbjct: 699 PLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVP--SPSLPPAGTPPGTKKVD---G 753
Query: 575 SSGGSSIGP--QPPSQGPADPAPSCRTNGV--AISDPSRCPQPAASSASEQ-RRPRFQAG 629
S S++ P P + P + + + T ++ + P P S S Q +RP + G
Sbjct: 754 ISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKG 813
Query: 630 TWSRQCRI----EEEEEVEQELL---SHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQN 682
+ I VE L S S+ + T HS + + PT +
Sbjct: 814 SAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPL 873
Query: 683 SKVGTGMSKSAS-----FAFEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQG 737
S G + + FPK+ P P PK L M SS + +
Sbjct: 874 SPKGVTLPPKETPTPSVVNLPFPKE-------GPATPAPKQAPALSMTSSSPKKARAT-- 924
Query: 738 SAESLSPSFRGVHVSFTTGSTDSLASDSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSG 797
P+ +G+ S + + + + GGP++ SP + A P P G
Sbjct: 925 ------PAPKGIPASPSPKGAPTPPAATPPSPKGGPATP---SPKWAPTPPAATPPSPKG 975
Query: 798 STEDVSPSGPQQPPPL-PQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHD 856
SP G PP P A SP +G+P P +P S
Sbjct: 976 GPATPSPKGAPTPPAATPPSPKGGPATPSP------KGAPTPPAVTPP-----SPKGSPA 1024
Query: 857 ESHFSYSLSPGNRHHPVFSSSDPLEKAFKGSGHWLPAAGLAGNRGGCGSPGLQCKGAPS 915
+ F S P P PAA L +GG +P L KGAP+
Sbjct: 1025 ATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSL--KGAPT 1081
Score = 39.7 bits (91), Expect = 0.021
Identities = 23/58 (39%), Positives = 29/58 (50%), Gaps = 7/58 (12%)
Query: 1157 QAGPG-PAPAPAPAPAAAAPPCSSAAP-----PAGGTLSPAAGPASPEG-PREKQLPR 1207
+ GP P+P AP P A PP +P P G + PAA P SP+G P LP+
Sbjct: 997 KGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPK 1054
Score = 37.4 bits (85), Expect = 0.10
Identities = 25/87 (28%), Positives = 34/87 (39%), Gaps = 4/87 (4%)
Query: 1162 PAPAPAPAPAAAAPPCS----SAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAK 1217
P AP PA PP + +PP G PAA P SP+G P+ +
Sbjct: 1281 PPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTP 1340
Query: 1218 QKPGGTPNLQQKKSQARLAPEIVSASQ 1244
P GTP L ++ P S+ +
Sbjct: 1341 PSPKGTPTLPATTPSSKGGPTTPSSKE 1367
Score = 36.6 bits (83), Expect = 0.17
Identities = 22/48 (45%), Positives = 26/48 (54%), Gaps = 5/48 (10%)
Query: 1157 QAGPG-PAPAPAPAPAAAAPPCSS---AAPP-AGGTLSPAAGPASPEG 1199
+ GP P+P AP P AA PP A PP G +PAA P SP+G
Sbjct: 1091 KGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKG 1138
Score = 36.2 bits (82), Expect = 0.23
Identities = 20/48 (41%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 1157 QAGPG-PAPAPAPAPAAAAPPCSSAAP----PAGGTLSPAAGPASPEG 1199
+ GP P+ AP P AA PP P P G + PAA P SP+G
Sbjct: 1068 KGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKG 1115
Score = 36.2 bits (82), Expect = 0.23
Identities = 20/46 (43%), Positives = 23/46 (50%), Gaps = 7/46 (15%)
Query: 1161 GPAPAP---APAPAAAAPPCSSAAP----PAGGTLSPAAGPASPEG 1199
GPA +P AP P AA PP +P P G PA P SP+G
Sbjct: 1300 GPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKG 1345
Score = 35.0 bits (79), Expect = 0.51
Identities = 18/42 (42%), Positives = 20/42 (47%), Gaps = 4/42 (9%)
Query: 1162 PAPAPAPAPAAAAPPCSSAAP----PAGGTLSPAAGPASPEG 1199
P+P AP P AA PP P P PAA P SP+G
Sbjct: 934 PSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKG 975
Score = 35.0 bits (79), Expect = 0.51
Identities = 18/42 (42%), Positives = 20/42 (47%), Gaps = 4/42 (9%)
Query: 1162 PAPAPAPAPAAAAPPCSSAA----PPAGGTLSPAAGPASPEG 1199
P P AP AA PP PP G +PAA P SP+G
Sbjct: 1143 PPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKG 1184
Score = 34.7 bits (78), Expect = 0.66
Identities = 26/80 (32%), Positives = 32/80 (40%), Gaps = 15/80 (18%)
Query: 1157 QAGPG-PAPAPAPAPAAAAPPC-----------SSAAPPAGGTLSPAAGPASPEGPREKQ 1204
+ GP P+P AP P AA PP + PPA SP GPA+P P+
Sbjct: 951 KGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATP-SPKGAP 1009
Query: 1205 LPRLIISNFLKAKQKPGGTP 1224
P + K P TP
Sbjct: 1010 TPPAVTPP--SPKGSPAATP 1027
Score = 33.5 bits (75), Expect = 1.5
Identities = 23/67 (34%), Positives = 28/67 (41%), Gaps = 4/67 (5%)
Query: 1162 PAPAPAPAPAAAAPPCSS---AAP-PAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAK 1217
P+P AP AA PP A P P G +PAA P SP+G P+ +
Sbjct: 1189 PSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATP 1248
Query: 1218 QKPGGTP 1224
P G P
Sbjct: 1249 PSPKGGP 1255
Score = 32.3 bits (72), Expect = 3.3
Identities = 19/42 (45%), Positives = 21/42 (50%), Gaps = 4/42 (9%)
Query: 1162 PAPAPAPAPAAAAPPCSS---AAP-PAGGTLSPAAGPASPEG 1199
P P AP AA PP A P P G +PAA P SP+G
Sbjct: 1166 PPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKG 1207
Score = 32.3 bits (72), Expect = 3.3
Identities = 29/89 (32%), Positives = 40/89 (44%), Gaps = 14/89 (15%)
Query: 1155 TLQAGPGPAPAPAPAP----AAAAPPCSSAAP-PAGGTLSPAAGPASPEGPREKQLPRLI 1209
TL A P+P PAP +++P + A P P G PA P+SP K++P
Sbjct: 1466 TLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSP-----KEVPATP 1520
Query: 1210 ISNFLKAKQKPGGTPNLQQKKSQARLAPE 1238
S + T L KK+ A LAP+
Sbjct: 1521 SSR----RDPIAPTATLLSKKTPATLAPK 1545
Score = 32.0 bits (71), Expect = 4.3
Identities = 23/71 (32%), Positives = 27/71 (38%), Gaps = 8/71 (11%)
Query: 1162 PAPAPAPAPAAAAPPCSSAAP----PAGGTLSPAAGPASPEG----PREKQLPRLIISNF 1213
P+P AP AA PP P P G PAA P S +G P K P +
Sbjct: 1235 PSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTP 1294
Query: 1214 LKAKQKPGGTP 1224
K P +P
Sbjct: 1295 PSPKGGPATSP 1305
Score = 31.6 bits (70), Expect = 5.6
Identities = 73/344 (21%), Positives = 116/344 (33%), Gaps = 35/344 (10%)
Query: 264 PVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAHPSCL 323
P + A Q S SP+ P Q G + P + PT P+ +
Sbjct: 48 PCSPAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLI 107
Query: 324 GPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLESDYCSLMKEPA--PEKQQDPGCP 381
GP ++ A + + + G+ +SS + + S+ K A P P
Sbjct: 108 GP---PISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSV 164
Query: 382 GVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQG 441
V S + P P+ P+ T + +E K P P + + +
Sbjct: 165 AVAESGSVITLSAPIAPSEPK--TNLNKVPSEVVPNPKGTPSPPCIVSTVPY-------- 214
Query: 442 QVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEEDHRTI--YLSSPDSAVGVQW 499
T A Q + PQ + T T+ A P+ TI L SP + G
Sbjct: 215 HCVTPMASIQSGVAS--------LPQTTPTTTLAIASPQVKDTTISSVLISPQNP-GSLS 265
Query: 500 PRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKSS----PVGSP 555
+GPVS + + S SS+++ + P + L +SS +
Sbjct: 266 LKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQ 325
Query: 556 VSPSAGGPPVSPLADLSDGSSGGS-----SIGPQPPSQGPADPA 594
PSA P + S+G S S+ P PS+ PA
Sbjct: 326 TGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPA 369
Score = 31.6 bits (70), Expect = 5.6
Identities = 17/42 (40%), Positives = 19/42 (45%), Gaps = 4/42 (9%)
Query: 1162 PAPAPAPAPAAAAPPCSSAA----PPAGGTLSPAAGPASPEG 1199
P AP AA PP PP G +PAA P SP+G
Sbjct: 1120 PPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKG 1161
Score = 31.6 bits (70), Expect = 5.6
Identities = 18/49 (36%), Positives = 21/49 (42%), Gaps = 5/49 (10%)
Query: 1157 QAGPG-PAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAG----PASPEGP 1200
+ PG P P AP P A PP P T + G P+S EGP
Sbjct: 1321 KGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGP 1369
Score = 30.8 bits (68), Expect = 9.6
Identities = 22/77 (28%), Positives = 30/77 (38%), Gaps = 10/77 (12%)
Query: 1158 AGPGPAPAPAPAPAAAAPPCSSAAP----------PAGGTLSPAAGPASPEGPREKQLPR 1207
A P P APA + +++P + A P P G PAA P SP+G P+
Sbjct: 901 ATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPK 960
Query: 1208 LIISNFLKAKQKPGGTP 1224
+ P G P
Sbjct: 961 WAPTPPAATPPSPKGGP 977
Score = 30.8 bits (68), Expect = 9.6
Identities = 20/62 (32%), Positives = 25/62 (40%), Gaps = 12/62 (19%)
Query: 1157 QAGPG-PAPAPAPAPAAAAPPC-----------SSAAPPAGGTLSPAAGPASPEGPREKQ 1204
+ GP P+P AP P AA PP + PPA SP PA+ P+
Sbjct: 974 KGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGAS 1033
Query: 1205 LP 1206
P
Sbjct: 1034 TP 1035
Score = 30.8 bits (68), Expect = 9.6
Identities = 17/43 (39%), Positives = 20/43 (46%), Gaps = 5/43 (11%)
Query: 1162 PAPAPAPAPAAAAPPCSSAAP-----PAGGTLSPAAGPASPEG 1199
P P A P AA PP +P P G +PAA SP+G
Sbjct: 1027 PFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKG 1069
Score = 30.8 bits (68), Expect = 9.6
Identities = 17/40 (42%), Positives = 20/40 (50%), Gaps = 2/40 (5%)
Query: 1160 PGPAPAPAPAPAAAAPPCSSAAP--PAGGTLSPAAGPASP 1197
P A P+P + AA P AP PA SP GPA+P
Sbjct: 1035 PPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATP 1074
>gi|14165272 PTEN induced putative kinase 1 precursor [Homo sapiens]
Length = 581
Score = 61.2 bits (147), Expect = 7e-09
Identities = 64/213 (30%), Positives = 83/213 (38%), Gaps = 39/213 (18%)
Query: 1118 RRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCTLQAGPGPAPAPAPAPAAAAPPC 1177
R +LLQL G++HL + GI HRDL +N+L+ P P A C
Sbjct: 337 RLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVEL---------DPDGCPWLVIADFGC 387
Query: 1178 SSAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQKPGGTPNLQQKK-SQARLA 1236
A G QLP F GG L + S AR
Sbjct: 388 CLADESIG-----------------LQLP------FSSWYVDRGGNGCLMAPEVSTARPG 424
Query: 1237 PEIVSASQYRKFDEFQTGILIYELLHQPNPF--EVRAQLRERDYRQEDLPPLPALSLYSP 1294
P V Y K D + G + YE+ NPF + +A L R Y++ LP LP P
Sbjct: 425 PRAVI--DYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALP--ESVPP 480
Query: 1295 GLQQLAHLLLEADPIKRIRIGEAKRVLQCLLWG 1327
++QL LL+ + KR A VL LWG
Sbjct: 481 DVRQLVRALLQREASKRPSARVAANVLHLSLWG 513
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 60.5 bits (145), Expect = 1e-08
Identities = 182/864 (21%), Positives = 291/864 (33%), Gaps = 182/864 (21%)
Query: 70 EDEG-VNSSPYSKPTIAVKPTMMSSEASDVWT-EANLSAEVSQVIWRRAPGKLPLPKQED 127
+D G ++SP K ++ + + S++S T ++N S++ + K+ LP QED
Sbjct: 1116 QDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQED 1175
Query: 128 AP----------------------VVYLGSFRGVQKP-AGPSTSPDG---NSRCPPAYTM 161
A +V+ + R + +G +SP+ NS P +
Sbjct: 1176 ATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQD 1235
Query: 162 VGLHNLEPRGER---NIAFHPVSFPEEKAVHKEKPSFPYQDRPSTQESFRQ--------- 209
L + + E I H S +E + + S ++RP+ + Q
Sbjct: 1236 EELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEA 1295
Query: 210 -KLAAFAGTTSGCHQGP-------GPLRESLPSEDDSDQRCSPSG------------DSE 249
++ + A + G H P PLRE+ + P G +
Sbjct: 1296 VEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDL 1355
Query: 250 GGEYCSILDCCPGSPVAKAASQTAGSRGRHGGRDCSPTCWEQG------KCSGPA-EQEK 302
G + + L+ P + + +++++G H + SP E+ S P +
Sbjct: 1356 NGPFLNQLETDPSLDMKEQSTRSSG----HSSSELSPDAVEKAGMSSNQSISSPVLDAVP 1411
Query: 303 RGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLESD 362
R PS + + P P+ S S + SS GL GSG+ S S
Sbjct: 1412 RTPSRERSSSASSPEMKDGL--PRTPSRRSRSG-SSPGLRDGSGTPSRHS---------- 1458
Query: 363 YCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAP 422
+ +P + P P S C P+P A P + +P S +
Sbjct: 1459 ----LSGSSPGMKDIPRTPSRGRSEC---DSSPEPKALP-QTPRPRSRSPSSPELNNKCL 1510
Query: 423 VPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEED 482
P + ++ E + + + G Q++ SG ++ D P S P+E
Sbjct: 1511 TPQRERSGSESSVDQKTVARTPLG----QRSRSGSSQEL-DVKPSAS---------PQE- 1555
Query: 483 HRTIYLSSPDSAVGVQWPRGPVSQNSEVGEE-ETSAGQGLSSRESHAHSASESKPKERPA 541
R+ SSPDS R P+ Q S G E + LS R S + S+ E K K R A
Sbjct: 1556 -RSESDSSPDSKAKT---RTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAA 1611
Query: 542 IPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPA--PSCRT 599
P+ S S P A P P S SS G P+ S + P P RT
Sbjct: 1612 --PRAQSGSD--SSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRT 1667
Query: 600 NGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNG 659
A P+P S + RR R R E + L S R +
Sbjct: 1668 ---ARRGSRSSPEPKTKSRTPPRR---------RSSRSSPELTRKARLSRRS--RSASSS 1713
Query: 660 PTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAFEFPKDRSGIETFSPPPPPPKSR 719
P S + HR P+ S P P KSR
Sbjct: 1714 PETRSRTPPRHRRSPS---------------------------------VSSPEPAEKSR 1740
Query: 720 HLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGSTDSLASDSRTCSDGGPSSELAH 779
+ +SS K + S SP RG+ S + + + R G S
Sbjct: 1741 SSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRR 1800
Query: 780 SPTN-------------SGKKLFAPVPFPSGSTEDVSPSGPQQPPPLPQKKIVSRAASSP 826
+ SG +P S T G + PP +K+ SR + +P
Sbjct: 1801 RQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAP 1860
Query: 827 DGFFWTQGSPKPGTASPKLNLSHS 850
W + + A+ + + S +
Sbjct: 1861 ----WKRSRSRASPATHRRSRSRT 1880
Score = 49.3 bits (116), Expect = 3e-05
Identities = 137/638 (21%), Positives = 221/638 (34%), Gaps = 101/638 (15%)
Query: 263 SPVA-KAASQTAGSRGRHGGRDC--SPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAH 319
SP+A + S++ R G R SP + SG + R + P G
Sbjct: 2046 SPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTP 2105
Query: 320 PSCLGPKKLSLTSEAAISSDGL----SCGSGSGSGASSPFVPHLESDYCSLMKEPAP--- 372
P L ++S S ++S L S G G+S + L+ S+M P P
Sbjct: 2106 PVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIP 2165
Query: 373 EKQQDPGCPGVTPSR-CLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKI 431
+ Q+ SR L LT A P + + A ++ APVP S +
Sbjct: 2166 DHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQ--VPAPVPLMS---L 2220
Query: 432 EHAAAAQGQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSP 491
A AA ++ +A A AS TP + + + + + L+SP
Sbjct: 2221 RTAPAANLASRIPAASAAAMNLASA-------RTPAIPTAVNLADSRTPAAAAAMNLASP 2273
Query: 492 -----DSAVGVQWPRGPVSQNSEVGEEETSAG------QGLSSRESHAHSASESKPKERP 540
SAV + PR P + + T A G + + A+ S S+ + P
Sbjct: 2274 RTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAP 2333
Query: 541 AI-----PPKLSKSSPVGSPVSPSAGG--PPVSPLADLSDGSSGGSSIGPQPPSQG---- 589
A P ++PV S +A P A ++ SG + P+ P
Sbjct: 2334 ASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERV 2393
Query: 590 -----------------PADPAPSCRTNGVAISDPSRCPQPAASSA-----SEQRRPRFQ 627
P+ P+ S T+ A S SR Q + S + R P
Sbjct: 2394 SGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPS 2453
Query: 628 AGTWSRQCRIEEEEEVE-QELLSHSWGRETKNGPTDHSNS-------------------- 666
A + +C I + V + LS T + DH+
Sbjct: 2454 AFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPAST 2513
Query: 667 -----TTWHRLHP-----TDGSSGQNSKVGTGMSKSASFAFEFPKDRSGIETFSPPPPPP 716
+ L P + SS +S + S S+S + S E S P P
Sbjct: 2514 GAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPE 2573
Query: 717 KSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGSTDSLASDSRTCSDGGPSSE 776
+ + + + + E V +G +P+ R S ++ S+ S +S S + S SS
Sbjct: 2574 VALKRVP-SPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSS 2632
Query: 777 LAHSPTNSGKKLFAPVPFPS--GSTEDVSPSGPQQPPP 812
+ S ++S + P P+ G P+ P++PPP
Sbjct: 2633 SSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPP 2670
Score = 45.8 bits (107), Expect = 3e-04
Identities = 73/353 (20%), Positives = 112/353 (31%), Gaps = 35/353 (9%)
Query: 361 SDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPP-AHPREATQPEPIYAESTKRKK 419
SD A K G +PS G GE P + P + P E+ ++
Sbjct: 272 SDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQP 331
Query: 420 AAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHP 479
++P K + K E +A S G + P PTP ++
Sbjct: 332 SSPYEDKDKDKKEKSATRPSPSP----------ERSSTGPEPPAPTPLLA---------- 371
Query: 480 EEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKER 539
E H SP + PV+ SE + + + S+ S P +
Sbjct: 372 -ERHG----GSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQ 426
Query: 540 PAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAPSCRT 599
P + + SSP +P+ G + S S G + + S P+ R+
Sbjct: 427 PTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRS 486
Query: 600 NGVAISDPSRCPQPAASSASEQRRPRFQ----AGTWSRQCRIEEEEEVEQELLSHSWGRE 655
A SR P S R P+++ A W R R + + W R
Sbjct: 487 PATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRS-RSPQRRGRSRSPQRPGWSRS 545
Query: 656 TKNGPTDHSNSTTWHRLH----PTDGSSGQNSKVGTGMSKSASFAFEFPKDRS 704
S S R H T G S + G S+S + A + R+
Sbjct: 546 RNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRT 598
Score = 44.3 bits (103), Expect = 8e-04
Identities = 140/721 (19%), Positives = 246/721 (34%), Gaps = 112/721 (15%)
Query: 183 PEEKAVHKEKP-------SFPYQDRPSTQESFRQKLAAFAGTTSGCHQGPGPL--RESLP 233
P++K K+K S P ++R + + ++K + + + H+ P P R+S
Sbjct: 185 PKQKKKKKKKDRGRRSESSSPRRERKKSSK--KKKHRSESESKKRKHRSPTPKSKRKSKD 242
Query: 234 SEDDSDQRCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGRH---GGRDCSPTCWE 290
+ + +P+ S + D S +++ S++A ++ GR SP
Sbjct: 243 KKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGR 302
Query: 291 QGKCSGPAEQEKRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDGLSCGSGSGSG 350
+G+ P + P +Q P S +
Sbjct: 303 RGEGDAPFSE-------PGTTSTQRP----------------------------SSPETA 327
Query: 351 ASSPFVPHLESDYCSLMKE-----PAPEKQQD-PGCPGVTPSRCLGLTGEPQPPAHPREA 404
P P+ + D K P+PE+ P P TP G PQP A +
Sbjct: 328 TKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLS 387
Query: 405 TQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRDSPDP 464
+P +E++ + +P KS K+ +++++ ++ A+S P P
Sbjct: 388 QEPVNPPSEASPTRDRSP--PKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAP 445
Query: 465 TP----QVSATITVM-AAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQ 519
P ++S++ T +H + +P +G R P + T +
Sbjct: 446 APGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRS--RSPATAKRGRSRSRTPTKR 503
Query: 520 GLSSRESHAHSASESKPK-ERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGG 578
G S S S S + R P + +S SP P + S + G
Sbjct: 504 GHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSR---SPQRPGWSRSRNTQRRGRSRSARRG 560
Query: 579 SSIGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIE 638
S P ++G + R SR P S + R R ++ T +R+ R
Sbjct: 561 RSHSRSPATRGRSRSRTPARRG----RSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSR 616
Query: 639 EEEEVEQELLSHS-WGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAF 697
+ + S R +++ + + R G S + G S+S +
Sbjct: 617 SRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRT--- 673
Query: 698 EFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGS 757
P RSG P +SR S V +G + S +P RG S +
Sbjct: 674 --PARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERK 731
Query: 758 TDSLASDSRTCSDGGPSSELAHSPTNSGKKLFAP-----------------VPFPSGSTE 800
S S R+ S+ P + + + + L +P P P ++
Sbjct: 732 NKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQ 791
Query: 801 DV---SPSGPQQPPP---LPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNV 854
S SG QP P ++ SR++SSP PK + +P SHS ++
Sbjct: 792 TPPRRSRSGSSQPKAKSRTPPRR--SRSSSSP--------PPKQKSKTPS-RQSHSSSSP 840
Query: 855 H 855
H
Sbjct: 841 H 841
Score = 40.8 bits (94), Expect = 0.009
Identities = 115/453 (25%), Positives = 160/453 (35%), Gaps = 97/453 (21%)
Query: 524 RESHAHSASESKPKERPAIPPKLSKSSP------VGSPVSPSAGGPPVSPLADLS-DGSS 576
R + S+SE K K R + S SSP + S S S P + LS S
Sbjct: 720 RRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSL 779
Query: 577 GGSSIGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCR 636
GSS P+ SQ P + S + A SR P P S +S P+ ++ T SRQ
Sbjct: 780 SGSSPCPKQKSQTPPRRSRSGSSQPKA---KSRTP-PRRSRSSSSPPPKQKSKTPSRQ-- 833
Query: 637 IEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFA 696
HS+S+ HP SG + G+ S A+
Sbjct: 834 -------------------------SHSSSSP----HPKV-KSGTPPRQGSITSPQANEQ 863
Query: 697 FEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRG-------- 748
P+ RS E S P P KSR + + S S +V + SPS
Sbjct: 864 SVTPQRRSCFE--SSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKA 921
Query: 749 -VHVSFTTGSTDSLASDSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGP 807
+ + S S S SR S P + SP ++ + P SGS+ + P
Sbjct: 922 IISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKP 981
Query: 808 QQPPPLPQKKIVS-----RAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSY 862
+ PP +S +A + P G G+ SP S+ ++ S
Sbjct: 982 ETPPRQSHSGSISPYPKVKAQTPP-------GPSLSGSKSP-CPQEKSKDSLVQSCPGSL 1033
Query: 863 SLSPGNRHHPVFSSSDPLEKAFKGSGHWLPAAGLAGNRGGCGSPGLQCKGAPSASSSQLS 922
SL G V SS+ P E F G LQ KG SQ S
Sbjct: 1034 SLCAG-----VKSSTPPGESYF-------------------GVSSLQLKG-----QSQTS 1064
Query: 923 VSSQASTGSTQL-QLHGLLSNISSKEGTYAKLG 954
++ T S ++ Q H ++ SK T K G
Sbjct: 1065 PDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGG 1097
Score = 40.0 bits (92), Expect = 0.016
Identities = 82/352 (23%), Positives = 115/352 (32%), Gaps = 65/352 (18%)
Query: 571 LSDGSSGGSSIGPQPPSQGPADPAPSCRT--NGVAISDPSRCPQP------------AAS 616
+SD GSS PQ ++ PAP + V S SR P P S
Sbjct: 141 ISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRS 200
Query: 617 SASEQRRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTT----WHRL 672
+S RR R ++ + E ++ + + R++K+ S STT R
Sbjct: 201 ESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRA 260
Query: 673 H-PTDGSSGQNSKVGTGMSKSA-------SFAFEFPKDRSG--------------IETFS 710
H T S +S S+SA + A P SG T
Sbjct: 261 HRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQR 320
Query: 711 PPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSP--SFRGVHVSFTT--------GSTDS 760
P P ++ + +K + S SP S G T GS
Sbjct: 321 PSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQP 380
Query: 761 LASDSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGPQQPPPLPQKKIVS 820
LA+ + P SE SPT +P P S+ + SP PQ K+
Sbjct: 381 LATTPLSQEPVNPPSEA--SPTRDRSPPKSPEKLPQSSSSESSPPSPQ------PTKVSR 432
Query: 821 RAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHHP 872
A+SSP+ SPKP A S + SH + H P
Sbjct: 433 HASSSPE-------SPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTP 477
Score = 35.4 bits (80), Expect = 0.39
Identities = 67/316 (21%), Positives = 108/316 (34%), Gaps = 53/316 (16%)
Query: 325 PKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVT 384
P S S I+ GS S S + D+ ++ PAP GV
Sbjct: 2452 PSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAP---------GV- 2501
Query: 385 PSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVC 444
P +G +PPA A QP + A +++ + S S + ++++
Sbjct: 2502 PHSDVG-----EPPASTG-AQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSS 2555
Query: 445 TGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPV 504
+G++ + S + PE + + +P V+ R P
Sbjct: 2556 SGSSSSDSEGSS------------------LPVQPEVALKRVPSPTPAPKEAVREGRPPE 2597
Query: 505 SQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPP 564
++ +S+ SS S + S+S S + S SS S SP+ GP
Sbjct: 2598 PTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQ 2657
Query: 565 VSPLADLSDGSSGGSSIGPQP---PSQGPADPAPSCR-TNGVAIS-------DPSRCPQP 613
P S P P S+ P P S R + ++ S P P+
Sbjct: 2658 ALP--------KPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRD 2709
Query: 614 AASSASEQRRPRFQAG 629
SS+SE+ R Q G
Sbjct: 2710 QQSSSSERGSRRGQRG 2725
Score = 33.5 bits (75), Expect = 1.5
Identities = 89/352 (25%), Positives = 122/352 (34%), Gaps = 59/352 (16%)
Query: 459 RDSPDPTP-QVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEE---- 513
R S P P Q S T + + H + +P + P+ ++ S +
Sbjct: 816 RSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQA--NEQSVTPQRRSCF 873
Query: 514 ETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSD 573
E+S L SR HS S S P P S + P SP S+ P V +
Sbjct: 874 ESSPDPELKSRTPSRHSCSGSSP------PRVKSSTPPRQSPSRSSSPQPKVKAIISPRQ 927
Query: 574 GSSGGSSIGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRF-QAGTWS 632
S GSS P+PS R SR P S+ + PR+ +G+ S
Sbjct: 928 RSHSGSS-----------SPSPS-RVTSRTTPRRSRSVSP-CSNVESRLLPRYSHSGSSS 974
Query: 633 RQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKS 692
+++ E Q SHS P + T P SG S SK
Sbjct: 975 PDTKVKPETPPRQ---SHS----GSISPYPKVKAQT----PPGPSLSGSKSPCPQEKSKD 1023
Query: 693 ASFAFEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGS----AESLSPSFRG 748
S P S PP +S SS L+ SQ S +++ SP R
Sbjct: 1024 -SLVQSCPGSLSLCAGVKSSTPPGES----YFGVSSLQLKGQSQTSPDHRSDTSSPEVRQ 1078
Query: 749 VHVSFTTGSTDSLASDSRTCSDGG------PSSELA-HSPTNSGKKLFAPVP 793
H + SL S S+T GG P +ELA SP + F+ P
Sbjct: 1079 SH-----SESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASP 1125
>gi|188536004 zinc finger protein 469 [Homo sapiens]
Length = 3925
Score = 58.9 bits (141), Expect = 3e-08
Identities = 160/725 (22%), Positives = 237/725 (32%), Gaps = 129/725 (17%)
Query: 45 GPPQPRAGSLP--PPPRLPPRPENCRLEDE--GVNSSPYSKPTIAVKPTMMSSEASDVWT 100
G PQ G P P RL R E + G+ SS +KPT+ P EA+ +
Sbjct: 91 GSPQTPPGRSPLQAPSRLAGRAEGSPPQRYILGIASSR-TKPTLDETPENPQLEAAQL-- 147
Query: 101 EANLSAEVSQVIWRRAPGKLPLPKQEDAPVVY-LGSFRGVQKPAGPSTSPDGNSRCPPAY 159
+ Q AP + LP+ E P LG R Q+P TS + S P+
Sbjct: 148 ---PEVDTPQGPGTGAPLRPGLPRTEAQPAAEELGFHRCFQEPPSSFTSTNYTS---PSA 201
Query: 160 TMVGLHNLEPRGERNIAFHPVSFPEEKAVHKEKPSFPYQDRPSTQESFRQKLAAFAGTTS 219
T P+ P S+PE +A + S+P P+ + SF
Sbjct: 202 TPRPPAPGPPQSRGTSPLQPGSYPEYQASGAD--SWP----PAAENSF------------ 243
Query: 220 GCHQGPGPLRESLPSEDDSDQRCS-PSGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGR 278
PG P+E + + S P G G + G+ + AG
Sbjct: 244 -----PGANFGVPPAEPEPIPKGSRPGGSPRGVSFQFPFPALHGASTKPFPADVAGHAFT 298
Query: 279 HGGRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAHPSCLG-PKKLSLTSEAAIS 337
+G + + Q + + P E GP++P P+ P G P L+ S+ +
Sbjct: 299 NGPLVFA---FHQPQGAWPEEAVGTGPAYPLPT-QPAPSPLPCYQGQPGGLNRHSDLS-- 352
Query: 338 SDGLSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPS----------- 386
G G+ A PF L ++ E P Q G PS
Sbjct: 353 --GALSSPGAAHSAPRPFSDSLHKSLTKILPERPPSAQDGLGSTRGPPSSLPQRHFPGQA 410
Query: 387 -RCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCT 445
R G+ P PP A P P AAP P+ + + GQ
Sbjct: 411 YRASGVDTSPGPPDTELAAPGPPPARLPQLWDPTAAPYPTPPGGPLAATRSMFFNGQPSP 470
Query: 446 GNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRG--- 502
G + +P P PQV T A P + P A G +W G
Sbjct: 471 GQRLCLP------QSAPLPWPQVLPT-----ARPSPHGMEMLSRLPFPAGGPEWQGGSQG 519
Query: 503 ---------------PVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKLS 547
P ++S+ G G++ + ++P+ P P L
Sbjct: 520 ALGTAGKTPGPREKLPAVRSSQGGSPALFTYNGMTDPGAQPLFFGVAQPQVSPHGTPSLP 579
Query: 548 KSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAPSCRTNGVAISDP 607
VG+ P SPL + ++G + P S PA+P+ S+
Sbjct: 580 PPRVVGA-------SPSESPLPSPATNTAGSTCSSLSPMSSSPANPS----------SEE 622
Query: 608 SRCPQPAASSASEQRRPRFQAGTWSRQCRIE-EEEEVEQELLSHSWGRETKNGPTDHSNS 666
S+ P P SA F T ++ E L +H K P
Sbjct: 623 SQLPGPLGPSAF------FHPPTHPQETGSPFPSPEPPHSLPTHYQPEPAKAFP------ 670
Query: 667 TTWHRLHPTDGSSGQNSKVGTGMSKSASFAFEFPK-DRSGIETFSPPPPPPKSRHLLKMN 725
P DG + + + F E P+ R G++ F P PPP H ++
Sbjct: 671 ------FPADGLGAEGA---FQCLEETPFPHEGPEVGRGGLQGF-PRAPPPYPTHHFSLS 720
Query: 726 KSSSD 730
+S D
Sbjct: 721 SASLD 725
Score = 35.8 bits (81), Expect = 0.30
Identities = 89/400 (22%), Positives = 132/400 (33%), Gaps = 64/400 (16%)
Query: 380 CPGVTPSRCLGLTGEPQPPAHPREATQPEPIYA-ESTKRKKAAPVPSKSQAKIEHAAAAQ 438
C V PS G + P P PI E + P PS S AA A
Sbjct: 3484 CSEVAPSTTKGWPETLERPVDP----VTHPIRGCELPSNHQECPPPSLSPFP---AALAD 3536
Query: 439 GQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHP-------EEDHRTIYLSSP 491
G+G C + ++ + SP P Q + + P E + S
Sbjct: 3537 GRGD-CALDGALERPENEASPGSPGPLLQQALPLGASLPRPGARGQDAEGKRAPLVFSGK 3595
Query: 492 DSAVGVQWPRGPVSQNSE---VGEEETSAGQGLSSRESHA--HSASESKP-------KER 539
A G + P + E+E S+ +S H S +KP K+R
Sbjct: 3596 RRAPGARGRCAPDHFQEDHLLQKEKEVSSSHMVSEGGPRGTFHKGSATKPAGCQSSSKDR 3655
Query: 540 PAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIG-----PQPPSQGPADPA 594
A + S + PV P ++P +L+ G+ G P P SQG P
Sbjct: 3656 SAAS---TPSKALKFPVHPRKAVGSLAP-GELARGTENGMKPATPKAKPGPSSQGSGSPR 3711
Query: 595 PSCRTNG-------------VAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEEEE 641
P +T G + P++ P+ S A E+ R QA + C E
Sbjct: 3712 PGTKTGGGSQPQPASGQLQSETATTPAKPSFPSRSPAPERLPARAQA----KSCTKGPRE 3767
Query: 642 EVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSA-SFAFEFP 700
EQ G GP + S+T + G + S G + SA P
Sbjct: 3768 AGEQ-------GPHGSLGPKEKGESSTKRKKGQVPGPARSESVGSFGRAPSAPDKPPRTP 3820
Query: 701 KDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAE 740
+ ++ P P P S++ K S+ K G +
Sbjct: 3821 RKQATPSRVLPTKPKPNSQN--KPRPPPSEQRKAEPGHTQ 3858
Score = 32.7 bits (73), Expect = 2.5
Identities = 14/43 (32%), Positives = 22/43 (51%)
Query: 1158 AGPGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGP 1200
A P +P P+PA A CSS +P + +P++ + GP
Sbjct: 586 ASPSESPLPSPATNTAGSTCSSLSPMSSSPANPSSEESQLPGP 628
Score = 32.3 bits (72), Expect = 3.3
Identities = 53/210 (25%), Positives = 72/210 (34%), Gaps = 17/210 (8%)
Query: 1024 CKAPEPKTVSYCSPSVPVHFNIQQDCGHFVASVPSS----MLSSPDAPKDPVPALPTHPP 1079
C+ P K+ P H + D H P+ +L +P +P P P
Sbjct: 2495 CQPPRKKSHRVSGKERPNHS--RGDPSHVTQPPPAQGSKEVLRAPGSPHSQ-QLHPPSPT 2551
Query: 1080 AQEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGI 1139
E D ++ P Q D + A + E + R G + K +
Sbjct: 2552 EHEVDVKTPASKPRPDQAREDELHPKQAEKR-EGRRWRREPTVDSPSHSEGKSNKKRGKL 2610
Query: 1140 IHRDLCLENLLLVHC-TLQAGPGPAPAPAPAPAAAAPP-CSS--AAPPAGGTLSP---AA 1192
R L E++L V + G G P+PA A AA+P C S P A G P
Sbjct: 2611 RGRRLREESILPVSADVISDGRGSRPSPAMASYAASPSHCLSVEGGPEADGEQPPRLATL 2670
Query: 1193 GPASPEGPREKQLPRLIISNFLKAKQKPGG 1222
GP EG E L QKP G
Sbjct: 2671 GPGVMEGAAETDQEALCAGE--TGAQKPPG 2698
Score = 31.2 bits (69), Expect = 7.3
Identities = 83/347 (23%), Positives = 118/347 (34%), Gaps = 71/347 (20%)
Query: 267 KAASQTAGSRGRHGGRDCSPTCWE------QGKCSGPAEQEKRGPSFPKECCSQGPTAHP 320
K A + G R R SP+ E +GK G +E+ + S G + P
Sbjct: 2577 KQAEKREGRRWRREPTVDSPSHSEGKSNKKRGKLRGRRLREESILPVSADVISDGRGSRP 2636
Query: 321 SCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQ---- 376
S ++ S AA S LS G + P P L + +M+ A Q+
Sbjct: 2637 SP------AMASYAASPSHCLSVEGGPEADGEQP--PRLATLGPGVMEGAAETDQEALCA 2688
Query: 377 -------DPG----CPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAEST-KRKKAAPVP 424
PG CPG LG Q A R P A K + P
Sbjct: 2689 GETGAQKPPGDRMLCPGRMDGAALGEQPTGQKGASARGFWGPRETKALGVCKESGSEPAE 2748
Query: 425 SKSQAKIEHAAAAQGQGQVCTGNAWAQKAA--SGWGRDSPDPTPQVSATITVMAAHPEED 482
S+A H+ + +G W + G +P S T + + P+
Sbjct: 2749 DSSRA---HSRSEEG--------VWEENTPPLGPLGFPETSSSPADSTTSSCLQGLPD-- 2795
Query: 483 HRTIYLSSPDSAVGVQWPRGPVSQNS--------EVGEEETSAGQ-----GLSSRESHAH 529
+PD+ GVQ P GP S + ++E S Q G +R+ + H
Sbjct: 2796 -------NPDTQGGVQGPEGPTPDASGSSAKDPPSLFDDEVSFSQLFPPGGRLTRKRNPH 2848
Query: 530 SASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSS 576
K E+P +P S G P+ G P DLSD SS
Sbjct: 2849 --VYGKRCEKPVLPLPTQPSFEEGG--DPTLG--PARLPTDLSDSSS 2889
Score = 30.8 bits (68), Expect = 9.6
Identities = 84/383 (21%), Positives = 131/383 (34%), Gaps = 61/383 (15%)
Query: 488 LSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKLS 547
++ P SA G R P +S + E S + H SE P P L
Sbjct: 3449 VAMPGSAPGPGEDRPPPRGSSPILSE--------GSLPALLHLCSEVAPSTTKGWPETLE 3500
Query: 548 KS-SPVGSPVS----PS----AGGPPVSPL-ADLSDGSSGGSSIGPQPPSQGPADPAPSC 597
+ PV P+ PS P +SP A L+DG + G + A P
Sbjct: 3501 RPVDPVTHPIRGCELPSNHQECPPPSLSPFPAALADGRGDCALDGALERPENEASPGSPG 3560
Query: 598 RTNGVAISDPSRCPQPAA--SSASEQRRPRFQAGTW---SRQCRIEEEEEVEQELLSHSW 652
A+ + P+P A A +R P +G + R + E LL
Sbjct: 3561 PLLQQALPLGASLPRPGARGQDAEGKRAPLVFSGKRRAPGARGRCAPDHFQEDHLLQKEK 3620
Query: 653 GRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAFEFP-KDRSGIETFSP 711
+ + ++ T+H+ T + Q+S + + S A +FP R + + +P
Sbjct: 3621 EVSSSHMVSEGGPRGTFHKGSATKPAGCQSSSKDRSAASTPSKALKFPVHPRKAVGSLAP 3680
Query: 712 -----------PPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHV-SFTTGSTD 759
P PK++ S S G P+ + + TT +
Sbjct: 3681 GELARGTENGMKPATPKAKPGPSSQGSGSPRPGTKTGGGSQPQPASGQLQSETATTPAKP 3740
Query: 760 SLASDS------------RTCSDG-------GPSSELA--HSPTNSGKKLFAPVPFPSGS 798
S S S ++C+ G GP L +S K+ VP P+ S
Sbjct: 3741 SFPSRSPAPERLPARAQAKSCTKGPREAGEQGPHGSLGPKEKGESSTKRKKGQVPGPARS 3800
Query: 799 TEDVS----PSGPQQPPPLPQKK 817
S PS P +PP P+K+
Sbjct: 3801 ESVGSFGRAPSAPDKPPRTPRKQ 3823
>gi|110832843 TBP-associated factor 4 [Homo sapiens]
Length = 1085
Score = 57.4 bits (137), Expect = 1e-07
Identities = 84/335 (25%), Positives = 122/335 (36%), Gaps = 48/335 (14%)
Query: 318 AHPSCLGPKKLSLTSEAAIS-SDGLSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQ 376
AH L P+ + + AA + + + GS +G+ + P P + + EP P +
Sbjct: 38 AHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAA--PEPPPAGRA 95
Query: 377 DPGCPGVTPSRCLGLTGEPQP--------PAHPREATQPEPIYAESTKRKKAAPVPSKSQ 428
PG G P R G P P PA P +P P + + APVP+ +
Sbjct: 96 RPGGGG--PQR----PGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGS----CAPVPAAAA 145
Query: 429 AKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD---SPDPTPQVSA------TITVMAAHP 479
A G + A A +A G G P P P A T+ AA
Sbjct: 146 VAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALL 205
Query: 480 EEDHR-----TIYLSSPDSAVGVQWPRGP---VSQNSEVGEEETSAGQGLSSRESHAHSA 531
H ++ + P + + + P P + VG A S + A +A
Sbjct: 206 NSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAA 265
Query: 532 SESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPA 591
+ P P P L++ P G P P P V P A +G S G++ P P + GPA
Sbjct: 266 PAAAPPPPPPAPATLAR--PPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPA 323
Query: 592 ----DPAP----SCRTNGVAISDPSRCPQPAASSA 618
P P + GV P R Q A +A
Sbjct: 324 GVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAA 358
Score = 42.0 bits (97), Expect = 0.004
Identities = 77/334 (23%), Positives = 118/334 (35%), Gaps = 56/334 (16%)
Query: 304 GPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLESDY 363
G + P + P A P+ P A ++ G +G ++P VP
Sbjct: 245 GAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVP------ 298
Query: 364 CSLMKEPAPEKQQDPGCPGVTPSRC------LGLTGEPQPPAHPREATQPEP-IYAESTK 416
P Q+ G G P+ G++G+P P A A P P + AES K
Sbjct: 299 -------PPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGA---AAAAPAPGVKAESPK 348
Query: 417 RK-KAAPVPSKSQAKIEHAAAAQG-------QGQVCTGNA----------WAQKAASGWG 458
R +AAP +++ A A+ A QG + + A K A+G
Sbjct: 349 RVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAV 408
Query: 459 RDSPDPTPQ-----VSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEE 513
S TP + AT+T P +P + Q P G V SE G+
Sbjct: 409 TQSLSRTPTATTSGIRATLTPTVLAPRLPQPP---QNPTNIQNFQLPPGMVLVRSENGQL 465
Query: 514 ETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGP----PVSPLA 569
Q L+ ++ AH+ ++ RPA P + + PV + G P V+P
Sbjct: 466 LMIPQQALAQMQAQAHAQPQTTMAPRPATP---TSAPPVQISTVQAPGTPIIARQVTPTT 522
Query: 570 DLSDGSSGGSSIGPQPPSQGPADPAPSCRTNGVA 603
+ S +++ P Q P G A
Sbjct: 523 IIKQVSQAQTTVQPSATLQRSPGVQPQLVLGGAA 556
Score = 35.8 bits (81), Expect = 0.30
Identities = 41/141 (29%), Positives = 52/141 (36%), Gaps = 25/141 (17%)
Query: 507 NSEVGEEETSAGQG-----LSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAG 561
NSEV E+ S G L++ +H H + P+ R A L GSP +
Sbjct: 14 NSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGA 73
Query: 562 GP-----------PVSPLADLSDGSSGGSSIGPQPPS-------QGPADPAPSCRTNGVA 603
GP P P A + GG P PPS GPA PA R
Sbjct: 74 GPAAPAEGAPGAAPEPPPAGRARPGGGGPQ-RPGPPSPRRPLVPAGPAPPAAKLRPPPEG 132
Query: 604 ISDPSRCPQPAASSASEQRRP 624
S S P PAA++ + P
Sbjct: 133 -SAGSCAPVPAAAAVAAGPEP 152
Score = 34.3 bits (77), Expect = 0.86
Identities = 25/45 (55%), Positives = 25/45 (55%), Gaps = 9/45 (20%)
Query: 1158 AGPGP--APAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGP 1200
A P P APAPA APAAA PP PPA TL A P P GP
Sbjct: 253 AAPSPPAAPAPA-APAAAPPP----PPPAPATL--ARPPGHPAGP 290
Score = 33.5 bits (75), Expect = 1.5
Identities = 23/42 (54%), Positives = 26/42 (61%), Gaps = 3/42 (7%)
Query: 1157 QAGPGPAPA-PAPAPAAAAPP-CSSAAPPAGGTLSPAAGPAS 1196
Q GPG A A PAP A +P AAPPA TL+ A+GPAS
Sbjct: 328 QPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLA-ASGPAS 368
Score = 32.7 bits (73), Expect = 2.5
Identities = 19/47 (40%), Positives = 21/47 (44%), Gaps = 4/47 (8%)
Query: 1158 AGPGPAPA----PAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGP 1200
AGP P A P A + P +AA A G AGPA P GP
Sbjct: 117 AGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGP 163
Score = 32.0 bits (71), Expect = 4.3
Identities = 23/68 (33%), Positives = 27/68 (39%), Gaps = 7/68 (10%)
Query: 1158 AGPGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGP--ASPEGPREKQLPRLIISNFLK 1215
AG GPA APA AP + PPAG GP P PR +P K
Sbjct: 71 AGAGPA-----APAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAK 125
Query: 1216 AKQKPGGT 1223
+ P G+
Sbjct: 126 LRPPPEGS 133
Score = 32.0 bits (71), Expect = 4.3
Identities = 20/55 (36%), Positives = 20/55 (36%), Gaps = 8/55 (14%)
Query: 1158 AGPGPAPAPAPAPAAAAPPCSSAA--------PPAGGTLSPAAGPASPEGPREKQ 1204
A A P PAPA A P AA P G P GP P GP Q
Sbjct: 142 AAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQ 196
Score = 32.0 bits (71), Expect = 4.3
Identities = 17/45 (37%), Positives = 19/45 (42%)
Query: 1157 QAGPGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGPR 1201
Q G APAPAPAA P S P G + A E P+
Sbjct: 304 QNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPK 348
Score = 30.8 bits (68), Expect = 9.6
Identities = 15/37 (40%), Positives = 17/37 (45%)
Query: 1156 LQAGPGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAA 1192
L A GP P P P P P A P A TL+ +A
Sbjct: 166 LAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSA 202
>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens]
Length = 2161
Score = 55.8 bits (133), Expect = 3e-07
Identities = 141/620 (22%), Positives = 201/620 (32%), Gaps = 130/620 (20%)
Query: 20 FVEHIWKPGSCKNCFCLRSDHQLVAGPPQPRAGSLPPPPRLPPRPENCRLEDEGVNSSPY 79
FVE + P N F + + L GPP P + P LPP P
Sbjct: 1563 FVEPLPPPLEFSNSF-EKPESPLTPGPPHPLPDTPAPATPLPPVPP-------------- 1607
Query: 80 SKPTIAVKPTMMSSEASDVWTEANLSAEVSQVIWRRAPGKLPLPKQEDAPVVYLGSFRGV 139
P +A P + S AS + + + A ++Q APG P P AP
Sbjct: 1608 --PAVAAAPPTLDSTASSLTSYDSEVATLTQGA-SAAPGD-PHPPGPPAPAA-------- 1655
Query: 140 QKPAGPSTSPDGNSRCPPAYTMVGLHNLEPRGERNIAFHPVSFPEEKAVHKEKPSFPYQD 199
PA P PD PP T G+ ++ R + HP+
Sbjct: 1656 PAPAAPQPGPD-----PPPGTDSGIEEVDSRSSSD---HPLE------------------ 1689
Query: 200 RPSTQESFRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQRCSPSGDSEGGEYCSILDC 259
+ S L+A G ++G G G S P D+ G + GG
Sbjct: 1690 -TISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDT-YVAYLDGQAFGGS------S 1741
Query: 260 CPGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAH 319
PG P + RGR G G P S + G A
Sbjct: 1742 TPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTG-AGTDGLLAL 1800
Query: 320 PSCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPG 379
+C GP + G G A P VP + S + ++ PG
Sbjct: 1801 RACSGPP---------------TAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPG 1845
Query: 380 CPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQG 439
P PP P QP+ + K + + SK Q Q
Sbjct: 1846 ---------------PPPPPLPGPLAQPQASALATVKASIISELSSKLQ---------QF 1881
Query: 440 QGQVCTGNA--WAQKAASGWGRDSPDPTPQV-SATITVMAAHPEEDHRTIYLSSPDSAVG 496
G G A WA+ + G G V T ++ +D ++ LS P S++
Sbjct: 1882 GGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSSLF 1941
Query: 497 VQWPRGPVSQ-NSEVGEEETSAGQGLSSRESHAHSASESK-----------PKERPAIPP 544
WP+ P+ + G T+A ++ S + S++ ++ P R A P
Sbjct: 1942 QNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSP 2001
Query: 545 KLSKSS---------PVGSPVSPSAGGPPVSPLADLSDGSSGGS--SIGPQPPSQGPADP 593
L +S P P+ PS GP L D+ +GG+ S P P P P
Sbjct: 2002 SLLPASEHKVSPAPRPSSLPILPS--GPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHP 2059
Query: 594 APSCRTNGVAISDPSRCPQP 613
S G A+S SR P
Sbjct: 2060 GISGGLGG-ALSGASRSLSP 2078
Score = 47.8 bits (112), Expect = 8e-05
Identities = 195/886 (22%), Positives = 277/886 (31%), Gaps = 178/886 (20%)
Query: 46 PPQPRAGSLP--PPPRLPPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSSEASDVWTEAN 103
PP+ G P PPPRL P+ G SP A P+ S +
Sbjct: 1023 PPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPG---APSPSHHGSAGGGGGSSQG 1079
Query: 104 LSAEVSQVIWRRAPGKLPLPKQED----APVVYLGSFRGVQK-----PAGPSTSPDGNSR 154
+ Q+ R A + +P + P+V G + P PS + + +
Sbjct: 1080 PALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQ 1139
Query: 155 CPPAYTMVGLHNLEPRGERNIAFHPVSFPEEKAVHKEKPSFPYQDRPSTQESFRQKLAAF 214
PPA N P I + P + + + P TQ
Sbjct: 1140 PPPAVAAPSEKNSIP-----IPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPE-----PTG 1189
Query: 215 AGTTSGCHQGPGPLRESLP-SEDDSDQRCSPSGDSEGGEYCSILDCCPGSPVAKAASQTA 273
G G P P +P S SPSG + LD ++ +
Sbjct: 1190 GGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPAT-------LDF-----TSQFGAALV 1237
Query: 274 GSRGRHGGRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTA-HPSCLGPKKLSLTS 332
G+ R GG S A E G + GP H + S
Sbjct: 1238 GAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEP 1297
Query: 333 EAAISSDGLSCGSGS---------GSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGV 383
+ S G G G G G SS F L + P K DP P
Sbjct: 1298 YLRLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPP---RPLVHPLTGKALDPASP-- 1352
Query: 384 TPSRCLGLT---------------GEPQPPAHPR----EATQPEP------IYAESTKRK 418
LGL G PQPP P EA P P + E R
Sbjct: 1353 -----LGLALAARERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRL 1407
Query: 419 KAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQK---------AASG-------WGRDSP 462
A P ++ ++ + A Q + + A + A G G + P
Sbjct: 1408 WGASPPDPARRELGYRAGLGSQEKSLPASPPAARRSLLHRLPPTAPGVGPLLLQLGTEPP 1467
Query: 463 DPTPQVSATITVMAAHPEEDHR----TIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAG 518
P P VS +A PEE R +L + V RGP S++ G S
Sbjct: 1468 APHPGVSKPWR--SAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGP-GVPPPSPR 1524
Query: 519 QGLSSRESHAHSASESK------PKERPAI-------------PPKLSKSSPVGSPVSPS 559
+ + + ++ E+ P P++ PP L S+ P SP
Sbjct: 1525 RSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPL 1584
Query: 560 AGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAP---------------SCRTNGVAI 604
GPP L D + + + P PP A P + T G +
Sbjct: 1585 TPGPP----HPLPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASA 1640
Query: 605 S----DPSRCPQPAA-SSASEQRRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNG 659
+ P P PAA + A+ Q P GT S ++ + L
Sbjct: 1641 APGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDHPL------------ 1688
Query: 660 PTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASF-----AFEFPKDRSGIETFSPPPP 714
T S ST GS+G G G++ A+ + G T PP P
Sbjct: 1689 ETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYP 1748
Query: 715 P----PKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGSTDSLASDSRTCSD 770
P P + S S G + ++P+ VS T TD L + R CS
Sbjct: 1749 PQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPT--SPTVSVTGAGTDGLLA-LRACS- 1804
Query: 771 GGPSSELAHSPTNSGKKLFAPVPFPSGST--EDVSP--SGPQQPPP 812
G P++ +A P ++ PVP P+ S+ + P GP PPP
Sbjct: 1805 GPPTAGVAGGPVAVEPEV-PPVPLPTASSLPRKLLPWEEGPGPPPP 1849
Score = 34.7 bits (78), Expect = 0.66
Identities = 22/80 (27%), Positives = 34/80 (42%), Gaps = 13/80 (16%)
Query: 1159 GPGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQ 1218
G P+PAPA +P +P SP PASP GP + + A +
Sbjct: 1195 GSSPSPAPAMSPVPPSP-------------SPVPTPASPSGPATLDFTSQFGAALVGAAR 1241
Query: 1219 KPGGTPNLQQKKSQARLAPE 1238
+ GG N +++S L+ +
Sbjct: 1242 REGGWQNEARRRSTLFLSTD 1261
Score = 31.2 bits (69), Expect = 7.3
Identities = 31/122 (25%), Positives = 46/122 (37%), Gaps = 7/122 (5%)
Query: 822 AASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHHPVFSSSDPLE 881
++ +P +QG +P ++P LS + + SP HP + P
Sbjct: 458 SSGAPGPTSGSQGQSQP--SAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRG 515
Query: 882 KAFKGSGHWLPAAGLAGNRGGCGSPG--LQCKGAPSASSSQLSVSSQASTGSTQLQLHGL 939
+ S P G AG GG G PG L +G S + S + S Q Q G
Sbjct: 516 RP---SSSGTPREGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGE 572
Query: 940 LS 941
+S
Sbjct: 573 IS 574
Score = 31.2 bits (69), Expect = 7.3
Identities = 24/70 (34%), Positives = 31/70 (44%), Gaps = 9/70 (12%)
Query: 534 SKPKERPAIPPKLSKS-----SPVGSPVSPSAGGP-PVSPLADLSDGSSGGSSIGPQPPS 587
S P+ + PP S S SP G P +P +GGP P S A S + +G + S
Sbjct: 927 SPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKS 986
Query: 588 ---QGPADPA 594
GP PA
Sbjct: 987 LYHSGPLPPA 996
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 52.4 bits (124), Expect = 3e-06
Identities = 144/664 (21%), Positives = 235/664 (35%), Gaps = 109/664 (16%)
Query: 347 SGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLT---GEPQPPAH--P 401
+G+ AS E D S +E + +++ P + ++ G T G PA P
Sbjct: 323 AGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESP 382
Query: 402 REATQPEP--------IYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKA 453
R+ P P A++ KR++ + S ++ E A AQ + +G A +A
Sbjct: 383 RKGAAPAPPGKTGPAVAKAQAGKREEDSQ-SSSEESDSEEEAPAQAKP---SGKAPQVRA 438
Query: 454 ASGWGRDSP-------DPTPQVSATITVMAAHPEEDHRTIYLSS---------------- 490
AS ++SP P A V EED R+ S
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 491 ---------PDSAVGVQWPRGPVSQNS------EVGEEETSA--GQGLSSRESHAHSASE 533
P S +G+ GP+ + + +VG SA G+ ES + +S+
Sbjct: 499 PLGKSPQVKPASTMGM----GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 554
Query: 534 SKPKERP-AIPPKLSKSSP---VGSPVSPSAGGPP--VSPLA-------DLSDGSSGGSS 580
S E P A+ P KS P S A GPP P+A + + S S
Sbjct: 555 SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEES 614
Query: 581 IGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEEE 640
+ PA + + I CP+ ++AS + P + GT Q +
Sbjct: 615 SDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP-VRVGT---QAPRKAG 670
Query: 641 EEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDG---SSGQNSKVGTGMS-KSASFA 696
S + T+ D S+S G + GQ VG G+ K+AS
Sbjct: 671 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 730
Query: 697 FEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTG 756
+ + P ++ + + S E+ S + SP+ V T
Sbjct: 731 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 790
Query: 757 STDSLASDSRTC-----SDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGPQQPP 811
+ A+ + + + G + A + S K+ PV P ST V GP P
Sbjct: 791 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNST--VLARGPASVP 848
Query: 812 PLPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHH 871
+ K V+ AA + G P+ + S S E++ +E+ + P + H
Sbjct: 849 SV--GKAVATAAQAQTG-------PEEDSGS-----SEEESDSEEEAETLAQVKPSGKTH 894
Query: 872 PVFSSSDPL-EKAFKGS-----GHWLPAAGLAGNRGGCGSPGLQCKGAPSASSSQLSVSS 925
+ ++ P E KG+ G P+A AG + GS + A ++ S
Sbjct: 895 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQD 954
Query: 926 QAST 929
Q S+
Sbjct: 955 QESS 958
Score = 37.4 bits (85), Expect = 0.10
Identities = 50/197 (25%), Positives = 81/197 (41%), Gaps = 24/197 (12%)
Query: 403 EATQPEPIYAESTKRKKAAPVPS--KSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD 460
E + P A + A +PS K +AK E A + G A + A+
Sbjct: 97 ETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGK-TGNSMPHPATGKTVANLLSGK 155
Query: 461 SPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQG 520
SP + + SA T+++ EE S P A G G VS AGQ
Sbjct: 156 SPRKSAEPSANTTLVSETEEEG------SVP--AFGAAAKPGMVS-----------AGQA 196
Query: 521 LSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPS-AGGPPVSPLADLSDGSSGGS 579
SS E + S+ E+ + +P++ P K+S V + SP+ P + D++ GG
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGG- 255
Query: 580 SIGPQPPSQGPADPAPS 596
++ P ++ P + + S
Sbjct: 256 ALPPAKRAKKPEEESES 272
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 52.0 bits (123), Expect = 4e-06
Identities = 47/197 (23%), Positives = 69/197 (35%), Gaps = 6/197 (3%)
Query: 235 EDDSDQRCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGR--HGGRDCSPTCWEQG 292
+D +++ S S S G S GS G GGR+CS
Sbjct: 2551 QDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAA---SS 2607
Query: 293 KCSGPAEQEKRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDGLSCGSGSGSGAS 352
+ + PA S S ++ S S +S ++ SS S S S S +S
Sbjct: 2608 RAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2667
Query: 353 SPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPAHPREATQPEPIYA 412
S E CS E AP P P++ G+ +P AH P P
Sbjct: 2668 SSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAP-QP 2726
Query: 413 ESTKRKKAAPVPSKSQA 429
++ + P+ K+QA
Sbjct: 2727 QAPPPQPTQPLQPKAQA 2743
Score = 45.1 bits (105), Expect = 5e-04
Identities = 68/320 (21%), Positives = 112/320 (35%), Gaps = 37/320 (11%)
Query: 524 RESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGS---- 579
+++ A S +K RP +L SP + + L G+ G
Sbjct: 2438 KKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKS 2497
Query: 580 --SIGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRP----RFQ-AGTWS 632
S+G PP+ G ++P + P P A+ + P F+ +G
Sbjct: 2498 LLSLGSYPPAAGSSEP---------------KAPWPKATDGDLAQEPGPGLTFEDSGNPK 2542
Query: 633 RQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTG--MS 690
+ + E++ +E S S + + S+S+ +G + GTG
Sbjct: 2543 SPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNC 2602
Query: 691 KSASFAFEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVH 750
+AS P S + S S + SSS S S+ S S S
Sbjct: 2603 SAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2662
Query: 751 VSFTTGSTDSLASDSRTCSD--------GGPSSELAHSPTNSGKKLFAPVPFPSGSTEDV 802
S ++ S+ + DS SD GPS++ A PT + K+ P +
Sbjct: 2663 SSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPSAQAA-LPTKATKQAGKARPSAHSPGKKT 2721
Query: 803 SPSGPQQPPPLPQKKIVSRA 822
PQ PPP P + + +A
Sbjct: 2722 PAPQPQAPPPQPTQPLQPKA 2741
Score = 40.4 bits (93), Expect = 0.012
Identities = 90/444 (20%), Positives = 147/444 (33%), Gaps = 85/444 (19%)
Query: 244 PSGDSEGGEYCSI-----LDCCPGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPA 298
PS ++G ++ D P +P+A S T GS+ SP + P
Sbjct: 2336 PSAKAKGDRAATLEEGNPTDEVPSTPLALEPSSTPGSKK-------SPPEPVDKRAKAP- 2387
Query: 299 EQEKRGPSFPKECCSQGPTAHPSCLGPKKLS-------------LTSEAAISSDGLSCGS 345
K P+ P+ S P A SC P+ + L + A +
Sbjct: 2388 ---KARPAPPQP--SPAPPAFTSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARA 2442
Query: 346 GSGSGASSPFVPHLESDYCSLMKE-----PAPEK-------QQDPGCPGVTPSRCLGLTG 393
SGA P P E++ + P +K ++DPG G + L G
Sbjct: 2443 AEESGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLG 2502
Query: 394 EPQPPAHPREATQPEPIYAESTKRKKAAP-----------VPSKSQAKIEHAAAAQGQGQ 442
P A E P P + ++ P P K+QA+ + A ++
Sbjct: 2503 SYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSS 2562
Query: 443 VCTGNAWAQKAASGWGRDSPDPTP-------------QVSATITVMAAHPEEDHRTIYLS 489
+G++ + ++S G ++ + + + AA P + S
Sbjct: 2563 SSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSS 2622
Query: 490 SPDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKS 549
S S+ S +S +S+ SS S + S+S S S S
Sbjct: 2623 SSSSSSSSS--SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCS 2680
Query: 550 SPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAPSCRTNGVAISDPSR 609
S + +P+AG P + A + + P S G PAP
Sbjct: 2681 SDDEAAPAPTAG--PSAQAALPTKATKQAGKARPSAHSPGKKTPAPQ------------- 2725
Query: 610 CPQPAASSASEQRRPRFQAGTWSR 633
PQ ++ +P+ QAG SR
Sbjct: 2726 -PQAPPPQPTQPLQPKAQAGAKSR 2748
Score = 38.1 bits (87), Expect = 0.060
Identities = 41/149 (27%), Positives = 58/149 (38%), Gaps = 16/149 (10%)
Query: 804 PSGPQQPPPLPQKKIVSRAASSPDG---FFWTQGSPKPGTASPKLNLSHSETNVHDESHF 860
P+ P P K + G F G+PK SP + + +E + +ES
Sbjct: 2506 PAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPK----SP--DKAQAEQDGAEESES 2559
Query: 861 SYSLSPGNRHHPVFSSSDPLEKAFKGSGHWLPAAGLAGNRGGCGSPGLQCKGAPSASSSQ 920
S S S G SSS + GS G GGCG+ G C A S ++S
Sbjct: 2560 SSSSSSG-------SSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASP 2612
Query: 921 LSVSSQASTGSTQLQLHGLLSNISSKEGT 949
S SS +S+ S+ S+ SS +
Sbjct: 2613 ASSSSSSSSSSSSSSSSSSSSSSSSSSSS 2641
Score = 35.0 bits (79), Expect = 0.51
Identities = 14/25 (56%), Positives = 15/25 (60%)
Query: 1160 PGPAPAPAPAPAAAAPPCSSAAPPA 1184
PGP P P+P P APP APPA
Sbjct: 326 PGPRPCPSPLPPPPAPPKGPPAPPA 350
Score = 33.9 bits (76), Expect = 1.1
Identities = 17/33 (51%), Positives = 18/33 (54%), Gaps = 2/33 (6%)
Query: 1155 TLQAGPGPAPAPAPAPAAA--APPCSSAAPPAG 1185
TL GP P P+P P P A PP AA PAG
Sbjct: 323 TLLPGPRPCPSPLPPPPAPPKGPPAPPAATPAG 355
Score = 31.2 bits (69), Expect = 7.3
Identities = 26/76 (34%), Positives = 32/76 (42%), Gaps = 11/76 (14%)
Query: 1164 PAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPAS-----PEGPREKQLPRLIISNFLKAKQ 1218
P P P P+ PP APP G PAA PA E RE R++ F+ + +
Sbjct: 326 PGPRPCPSPLPPP---PAPPKGPPAPPAATPAGVYTVFREQGREH---RVVAPTFVPSVE 379
Query: 1219 KPGGTPNLQQKKSQAR 1234
P Q SQAR
Sbjct: 380 AFDERPGPIQIASQAR 395
>gi|239743293 PREDICTED: mucin 12 [Homo sapiens]
Length = 5478
Score = 50.4 bits (119), Expect = 1e-05
Identities = 182/819 (22%), Positives = 279/819 (34%), Gaps = 142/819 (17%)
Query: 201 PSTQESFRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQRCSPSGDSEGGEYCSILDCC 260
PS+ S L+ TTSG P R S S + + SP+ S E +
Sbjct: 2945 PSSSGSTGTTLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLS-EKSTTFYTS 3003
Query: 261 PGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQG----P 316
P SP A + T S G E+ S +FP + G P
Sbjct: 3004 PRSPDATLSPATTTSSGVS----------EESSTSHSQPGSTHTTAFPDSTTTSGLSQEP 3053
Query: 317 TAHPSCLGPKKLSL----TSEAAISSDGLSCGSGSG-------------SG---ASSPFV 356
TA S G + +L T+ +++ + S G SG AS+P
Sbjct: 3054 TASHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTH 3113
Query: 357 PHLESDYCSL---------MKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPA---HPREA 404
S + +L ++E + Q P TPS G T P + H R +
Sbjct: 3114 SSTGSLHTTLTPASSTSAGLQEESTTFQSWPSSSDTTPSPP-GTTAAPVEVSTTYHSRPS 3172
Query: 405 TQPEPIYAEST----KRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD 460
+ P ++ S+ + +++ V S A + V G +SG
Sbjct: 3173 STPTTHFSASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSG---- 3228
Query: 461 SPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQG 520
S + T +T T + + T + SSP S P S S V EE T++
Sbjct: 3229 STETTALPGSTTTAGLS----EKSTTFYSSPRSPDTTLSPASTTS--SGVSEESTTS--- 3279
Query: 521 LSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSS 580
SR H+ A P S + P S S ++ P S LS GS+ SS
Sbjct: 3280 -HSRPGSTHTT---------AFPG--STTMPGVSQESTASHSSPGSTDTTLSPGSTTASS 3327
Query: 581 IGPQPPS--QGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIE 638
+GP+ + GP + + S P SS AG+ +RQ
Sbjct: 3328 LGPESTTFHSGPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGEST 3387
Query: 639 EEEE------------------VEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSG 680
+ VE SH T PT H ++++ T G S
Sbjct: 3388 TFQSWPNSKDTTPAPPTTTSAFVELSTTSHGSPSST---PTTHFSASS-----TTLGRSE 3439
Query: 681 QNSKVGTGMSKSASFAFEFPKDRSGI----ETFSPPPPPPKSRHLLKMNKSSSDLEKVSQ 736
+++ V + +A+ SG+ T+ P ++ H + + +S E+ +
Sbjct: 3440 ESTTVHSSPVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESDTTSGRGEESTT 3499
Query: 737 GSAE-----SLSPSFRGVHVSFTTGSTDSLAS-------DSRTCSDGGPSSELAHSPTNS 784
+ S +PS V T S S DS T S S +HS ++
Sbjct: 3500 SHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDA 3559
Query: 785 GKKLFAPVPFPSG-----STEDVSPSGPQQPPPLPQKKIVSRAASSPDGFFWTQGSPKPG 839
+ P + ST SG + LP + F + SP
Sbjct: 3560 TGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPRSPAT- 3618
Query: 840 TASPKLNLSHSETNVHDESHFSYSLSPGNRHHPVF--SSSDPLEKAFKGSGHWLPAAGLA 897
T SP S + + V +ES S+S PG+ H F S++ P + H P
Sbjct: 3619 TLSP---ASTTSSGVSEESTTSHS-RPGSTHTTAFPDSTTTPGLSRHSTTSHSSP----- 3669
Query: 898 GNRGGCGSPGLQCKGAPSASSSQLSVSSQASTGSTQLQL 936
G L ++ SSQ S +S +S+GST L
Sbjct: 3670 ----GSTDTTLLPASTTTSGSSQESTTSHSSSGSTDTAL 3704
Score = 49.3 bits (116), Expect = 3e-05
Identities = 115/506 (22%), Positives = 177/506 (34%), Gaps = 74/506 (14%)
Query: 458 GRDSPDPTPQVSATITVMAAHPEE----DHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEE 513
G +P P S T + + + T + SSP S P S S V EE
Sbjct: 606 GDSTPSPISSGSMETTALPGSTTKPGLSEKSTTFYSSPRSPDTTHLPASMTS--SGVSEE 663
Query: 514 ETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSD 573
T++ S + A S + P LS+ S S S+ GP + L S
Sbjct: 664 STTSHSRPGSTHTTAFPGSTTMPG--------LSQESTA----SHSSPGPTDTTL---SP 708
Query: 574 GSSGGSSIGPQPPS--QGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTW 631
GS+ SS+GP+ + P + + S P SS AG+
Sbjct: 709 GSTTASSLGPEYTTFHSRPGSTETTLLPDNTTASGLLEASMPVHSSTRSPHTTLSPAGST 768
Query: 632 SRQCRIEEEEEVEQELLSHSW--GRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGM 689
+RQ + HSW ++T+ P +TT + P+ S G S + T
Sbjct: 769 TRQ---------GESTTFHSWPSSKDTRPAPP----TTTSAFVEPSTTSHGSPSSIPTTH 815
Query: 690 SKSASFAFEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAE-----SLSP 744
+ S ++ + T+ P ++ H + + +S E+ + + S +P
Sbjct: 816 ISARSTTSGLVEEST---TYHSSPGSTQTMHFPESDTTSGRGEESTTSHSSTTHTISSAP 872
Query: 745 SFRGVHVSFTTGSTDSLAS-------DSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSG 797
S V T S S DS T S S +HS ++ + P +
Sbjct: 873 STTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTS 932
Query: 798 -----STEDVSPSGPQQPPPLPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSET 852
ST SG + LP + F + SP T SP S + +
Sbjct: 933 VLLGESTTSPISSGSMETTALPGSTTTPGLSERSTTFHSSPRSPAT-TLSP---ASTTSS 988
Query: 853 NVHDESHFSYSLSPGNRHHPVF--SSSDPLEKAFKGSGHWLPAAGLAGNRGGCGSPGLQC 910
V +ES S S PG+ H F S++ P + H P G L
Sbjct: 989 GVSEESTTSRS-RPGSTHTTAFPDSTTTPGLSRHSTTSHSSP---------GSTDTTLLP 1038
Query: 911 KGAPSASSSQLSVSSQASTGSTQLQL 936
++ SQ S +S +S+GST L
Sbjct: 1039 ASTTTSGPSQESTTSHSSSGSTDTAL 1064
Score = 49.3 bits (116), Expect = 3e-05
Identities = 94/415 (22%), Positives = 151/415 (36%), Gaps = 27/415 (6%)
Query: 459 RDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAG 518
R P T + + E+ T+Y SSP S +PR P + S GEE T+
Sbjct: 2359 RSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRTPTT--SVRGEEPTT-- 2414
Query: 519 QGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGG 578
SR + H+ ++ + + S + P GSP S G P ADL + S+
Sbjct: 2415 --FHSRPASTHTTLFTEDSTTSGLTEE-STAFP-GSPASTQTGLPATLTTADLGEEST-- 2468
Query: 579 SSIGPQPPSQGPA----DPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQ 634
P S G PA S + V S PSR + + + P + +
Sbjct: 2469 ----TFPSSSGSTGTTLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKST 2524
Query: 635 CRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSAS 694
+ L S T +G ++ S ST+ + T ++ +S G+S+ ++
Sbjct: 2525 TFYTSPRSPDATL---SPATTTSSGVSEES-STSHSQPGSTHTTAFPDSTTTPGLSRHST 2580
Query: 695 FAFEFP--KDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVS 752
+ P D + + + P + + S+D +S GS +LS
Sbjct: 2581 TSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTD-TALSPGSTTALSFGQESTTFH 2639
Query: 753 FTTGST-DSLASDSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGPQQPP 811
+ GST +L DS T S +S HS T S + +P S + S + P
Sbjct: 2640 SSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTTFQTHPA 2699
Query: 812 PLPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSP 866
A++P T PG+ + S T+ H E + SP
Sbjct: 2700 STHTTPSPPSTATAPVEESTTY-HRSPGSTPTTHFPASSTTSGHSEKSTIFHSSP 2753
Score = 48.1 bits (113), Expect = 6e-05
Identities = 120/483 (24%), Positives = 171/483 (35%), Gaps = 85/483 (17%)
Query: 459 RDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAG 518
R P T + + E+ T+Y SSP S +PR + S GEE T+
Sbjct: 2833 RSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRS--TTTSVRGEEPTT-- 2888
Query: 519 QGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGG 578
SR + H+ ++ + + S + P GSP S G P ADL + S+
Sbjct: 2889 --FHSRPASTHTTLFTEDSTTSGLTEE-STAFP-GSPASTQTGLPATLTTADLGEEST-- 2942
Query: 579 SSIGPQPPSQGPA----DPAPSCRTNGVAISDPSRCP-----------QPAASSASEQ-- 621
P S G PA S + V S PSR P S SE+
Sbjct: 2943 ----TFPSSSGSTGTTLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKST 2998
Query: 622 ---RRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGS 678
PR T S E+ SHS T S +T+ PT
Sbjct: 2999 TFYTSPRSPDATLS-PATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTASH 3057
Query: 679 SGQNSKVGT---GMSKSASFAFE---------------FPKD--RSG-IETFSPPPPPPK 717
S Q S T G + ++S + P D SG +E +P
Sbjct: 3058 SSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTG 3117
Query: 718 SRH--LLKMNKSSSDLEKVSQ-----GSAESLSPSFRG-----VHVSFTTGS------TD 759
S H L + +S+ L++ S S+ +PS G V VS T S T
Sbjct: 3118 SLHTTLTPASSTSAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTT 3177
Query: 760 SLASDSRTCSDGGPSSELAHSPTNSGKKLF-----APVPFPSGSTEDVSPSGPQQPPPLP 814
++ S T S+ + SP +G LF V +T +S SG + LP
Sbjct: 3178 HFSASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPIS-SGSTETTALP 3236
Query: 815 QKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHHPVF 874
+ + F+ + SP T SP S + + V +ES S+S PG+ H F
Sbjct: 3237 GSTTTAGLSEKSTTFYSSPRSPDT-TLSP---ASTTSSGVSEESTTSHS-RPGSTHTTAF 3291
Query: 875 SSS 877
S
Sbjct: 3292 PGS 3294
Score = 47.8 bits (112), Expect = 8e-05
Identities = 130/544 (23%), Positives = 188/544 (34%), Gaps = 96/544 (17%)
Query: 459 RDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAG 518
R P T + + E+ T+Y SSP S +PR S + V EE +
Sbjct: 3916 RSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPR---STTTSVRREEPTT- 3971
Query: 519 QGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGS--- 575
SR + H+ ++ + + S + P GSP S G P ADL + S
Sbjct: 3972 --FHSRPASTHTTLFTEDSTTSGLTEE-STAFP-GSPASTQTGLPATLTTADLGEESTTF 4027
Query: 576 -SGGSSIGPQPPSQGPADPAPSCRTNGVAISDPSRCP-----------QPAASSASEQ-- 621
S S G + PA S + V S PSR P S SE+
Sbjct: 4028 PSSSGSTGTK------LSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKST 4081
Query: 622 ---RRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGS 678
PR T S E+ SHS T S +T+ PT
Sbjct: 4082 TFYTSPRSPDATLS-PATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTTSH 4140
Query: 679 SGQNSKVGT---GMSKSASFAFE---------------FPKD--RSG-IETFSPPPPPPK 717
S Q S T G + ++S + P D SG +E +P
Sbjct: 4141 SSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTG 4200
Query: 718 SRH--LLKMNKSSSDLEK--------VSQGSAESLSPSFRGVHVSFTT--------GSTD 759
S H L + +S+ L++ S PS V V +T T
Sbjct: 4201 SLHTTLTPASSTSTGLQEESTTFQSWPSSSDTTPSPPSTTAVPVEVSTTYHSRPSSTPTT 4260
Query: 760 SLASDSRTCSDGGPSSELAHSPTNSGKKLF-----APVPFPSGSTEDVSPSGPQQPPPLP 814
++ S T S+ + SP +G LF V +T +S SG + LP
Sbjct: 4261 HFSASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPIS-SGSTETTALP 4319
Query: 815 QKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHHPVF 874
+ + F+ + SP T SP S + + V +ES S+S PG+ H F
Sbjct: 4320 GSTTTAGLSEKSTTFYSSPRSPDT-TLSP---ASTTSSGVSEESTTSHS-RPGSMHTTAF 4374
Query: 875 SSSDPLEKAFKGS--GHWLPAAGLAGNRGGCGSPGLQCKGAPSASSSQLSVSSQASTGST 932
SS + + S H P G+ SPG ++S S + +S GST
Sbjct: 4375 PSSTTMPGVSQESTASHSSP-----GSTDTTLSPG----STTASSLGPESTTFHSSPGST 4425
Query: 933 QLQL 936
+ L
Sbjct: 4426 ETTL 4429
Score = 44.7 bits (104), Expect = 6e-04
Identities = 182/819 (22%), Positives = 275/819 (33%), Gaps = 142/819 (17%)
Query: 201 PSTQESFRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQRCSPSGDSEGGEYCSILDCC 260
PS+ S KL+ TTSG P R S S + + SP+ S E +
Sbjct: 1388 PSSSGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLS-EKSTTFYTS 1446
Query: 261 PGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQEKRGPSFPKECC----SQGP 316
P SP A + T S G E+ S +FP SQ P
Sbjct: 1447 PRSPDATLSPATTTSSGVS----------EESSTSHSQPGSTHTTAFPDSTTTSDLSQEP 1496
Query: 317 TAHPSCLGPKKLSL----TSEAAISSDGLSCGSGSG-------------SG---ASSPFV 356
T S G + +L T+ +++ + S G SG AS+P
Sbjct: 1497 TTSHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTH 1556
Query: 357 PHLESDYCSL---------MKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPA---HPREA 404
S + +L ++E + Q P TPS G T P + H R +
Sbjct: 1557 SSTGSLHTTLTPASSTSAGLQEESTTFQSWPSSSDTTPSPP-GTTAAPVEVSTTYHSRPS 1615
Query: 405 TQPEPIYAEST----KRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD 460
+ P ++ S+ + +++ V S A + V G +SG
Sbjct: 1616 STPTTHFSASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSG---- 1671
Query: 461 SPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQG 520
S + T +T T + + T + SSP S P S S V EE T++
Sbjct: 1672 STETTALPGSTTTAGLS----EKSTTFYSSPRSPDTTLSPASTTS--SGVSEESTTS--- 1722
Query: 521 LSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSS 580
SR H+ A P S + P S S ++ P S LS GS+ SS
Sbjct: 1723 -HSRPGSTHTT---------AFPG--STTMPGVSQESTASHSSPGSTDTTLSPGSTTASS 1770
Query: 581 IGPQPPS--QGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIE 638
+GP+ + P + + S P SS AG+ +RQ
Sbjct: 1771 LGPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGEST 1830
Query: 639 EEEE------------------VEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSG 680
+ VE SH T PT H ++++ T G S
Sbjct: 1831 TFQSWPSSKDTMPAPPTTTSAFVELSTTSHGSPSST---PTTHFSASS-----TTLGRSE 1882
Query: 681 QNSKVGTGMSKSASFAFEFPKDRSGI----ETFSPPPPPPKSRHLLKMNKSS--SDLEKV 734
+++ V + +A+ SG+ + P ++ H + + +S S+ +
Sbjct: 1883 ESTTVHSSPVATATTPSPARSTTSGLVEESTAYHSSPGSTQTMHFPESSTASGRSEESRT 1942
Query: 735 SQGSAE---SLSPSFRGVHVSFTTGSTDSLAS-------DSRTCSDGGPSSELAHSPTNS 784
S S S PS V T S S DS T S S +HS ++
Sbjct: 1943 SHSSTTHTISSPPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDA 2002
Query: 785 GKKLFAPVPFPSG-----STEDVSPSGPQQPPPLPQKKIVSRAASSPDGFFWTQGSPKPG 839
+ P + ST SG + LP + F + SP
Sbjct: 2003 TGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPRSPAT- 2061
Query: 840 TASPKLNLSHSETNVHDESHFSYSLSPGNRHHPVF--SSSDPLEKAFKGSGHWLPAAGLA 897
T SP S + + V +ES S+S PG+ H F S++ P + H P
Sbjct: 2062 TLSP---ASTTSSGVSEESTTSHS-RPGSTHTTAFPDSTTTPGLSRHSTTSHSSP----- 2112
Query: 898 GNRGGCGSPGLQCKGAPSASSSQLSVSSQASTGSTQLQL 936
G L ++ SQ S +S +S GST L
Sbjct: 2113 ----GSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTAL 2147
Score = 43.9 bits (102), Expect = 0.001
Identities = 132/544 (24%), Positives = 191/544 (35%), Gaps = 96/544 (17%)
Query: 459 RDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAG 518
R P T + + E+ T+Y SS S +P + S GEE T+
Sbjct: 1276 RSQPGSTHSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFPHSTTT--SVHGEEPTT-- 1331
Query: 519 QGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGS--- 575
SR + H+ ++ + + S + P GSP S G P ADL + S
Sbjct: 1332 --FHSRPASTHTTLFTEDSTTSGLTEE-STAFP-GSPASTQTGLPATLTTADLGEESTTF 1387
Query: 576 -SGGSSIGPQPPSQGPADPAPSCRTNGVAISDPSRCP-----------QPAASSASEQ-- 621
S S G + PA S + V S PSR P S SE+
Sbjct: 1388 PSSSGSTGTK------LSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKST 1441
Query: 622 ---RRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGS 678
PR T S E+ SHS T S +T+ PT
Sbjct: 1442 TFYTSPRSPDATLS-PATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSDLSQEPTTSH 1500
Query: 679 SGQNSKVGT---GMSKSASFAFE---------------FPKD--RSG-IETFSPPPPPPK 717
S Q S T G + ++S + P D SG +E +P
Sbjct: 1501 SSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTG 1560
Query: 718 SRH--LLKMNKSSSDLEKVSQ-----GSAESLSPSFRG-----VHVSFTTGS------TD 759
S H L + +S+ L++ S S+ +PS G V VS T S T
Sbjct: 1561 SLHTTLTPASSTSAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTT 1620
Query: 760 SLASDSRTCSDGGPSSELAHSPTNSGKKLF-----APVPFPSGSTEDVSPSGPQQPPPLP 814
++ S T S+ + SP +G LF V +T +S SG + LP
Sbjct: 1621 HFSASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPIS-SGSTETTALP 1679
Query: 815 QKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHHPVF 874
+ + F+ + SP T SP S + + V +ES S+S PG+ H F
Sbjct: 1680 GSTTTAGLSEKSTTFYSSPRSPDT-TLSP---ASTTSSGVSEESTTSHS-RPGSTHTTAF 1734
Query: 875 SSSDPLEKAFKGS--GHWLPAAGLAGNRGGCGSPGLQCKGAPSASSSQLSVSSQASTGST 932
S + + S H P G+ SPG ++S S + +S GST
Sbjct: 1735 PGSTTMPGVSQESTASHSSP-----GSTDTTLSPG----STTASSLGPESTTFHSSPGST 1785
Query: 933 QLQL 936
+ L
Sbjct: 1786 ETTL 1789
Score = 42.7 bits (99), Expect = 0.002
Identities = 162/746 (21%), Positives = 243/746 (32%), Gaps = 143/746 (19%)
Query: 201 PSTQESFRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQRCSPSGDSEGGEYCSILDCC 260
PS+ S KL+ TTSG P R S S + + SP+ S E +
Sbjct: 4028 PSSSGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLS-EKSTTFYTS 4086
Query: 261 PGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQG----P 316
P SP A + T S G E+ S +FP + G P
Sbjct: 4087 PRSPDATLSPATTTSSGVS----------EESSTSHSQPGSTHTTAFPDSTTTSGLSQEP 4136
Query: 317 TAHPSCLGPKKLSL----TSEAAISSDGLSCGSGSG-------------SG---ASSPFV 356
T S G + +L T+ +++ + S G SG AS+P
Sbjct: 4137 TTSHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTH 4196
Query: 357 PHLESDYCSL---------MKEPAPEKQQDPGCPGVTPS--RCLGLTGEPQPPAHPREAT 405
S + +L ++E + Q P TPS + E H R ++
Sbjct: 4197 SSTGSLHTTLTPASSTSTGLQEESTTFQSWPSSSDTTPSPPSTTAVPVEVSTTYHSRPSS 4256
Query: 406 QPEPIYAEST----KRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRDS 461
P ++ S+ + +++ V S A + V G +SG S
Sbjct: 4257 TPTTHFSASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSG----S 4312
Query: 462 PDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQGL 521
+ T +T T A E T Y S PR P + S TS+G
Sbjct: 4313 TETTALPGSTTT---AGLSEKSTTFYSS----------PRSPDTTLSPAST--TSSGVSE 4357
Query: 522 SSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSI 581
S SH+ S A P S + P S S ++ P S LS GS+ SS+
Sbjct: 4358 ESTTSHSRPGS----MHTTAFPS--STTMPGVSQESTASHSSPGSTDTTLSPGSTTASSL 4411
Query: 582 GPQPPS--QGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEE 639
GP+ + P + + S P SS AG+ +RQ
Sbjct: 4412 GPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTT 4471
Query: 640 EEE------------------VEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQ 681
+ VE SH T PT H ++++ T G S +
Sbjct: 4472 FQSWPNSKDTTPAPPTTTSAFVELSTTSHGSPSST---PTTHFSASS-----TTLGRSEE 4523
Query: 682 NSKVGTGMSKSASFAFEFPKDRSGI----ETFSPPPPPPKSRHLLKMNKSSSDLEKVSQG 737
++ V + +A+ SG+ T+ P ++ H + N +S E+ +
Sbjct: 4524 STTVHSSPVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESNTTSGRGEESTTS 4583
Query: 738 SAE-----SLSPSFRGVHVSFTTGSTDSLAS-------DSRTCSDGGPSSELAHSPTNSG 785
+ S +PS V T S S DS T S S +HS ++
Sbjct: 4584 HSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDAT 4643
Query: 786 KKLFAPV--------------PFPSGSTEDVSPSGPQQPPPLPQKKIV--SRAASSPDGF 829
+ P P SGS E + G P L +K S +S+P
Sbjct: 4644 GTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPSSTPTTH 4703
Query: 830 FWTQGSPKPGTASPKLNLSHSETNVH 855
F +S L S T VH
Sbjct: 4704 F--------SASSTTLGRSEESTTVH 4721
Score = 36.6 bits (83), Expect = 0.17
Identities = 136/689 (19%), Positives = 225/689 (32%), Gaps = 137/689 (19%)
Query: 392 TGEPQPPAHPREAT--QPEPIYAESTKRKK---AAPVPSKSQAKIEHAAAAQGQGQVCTG 446
TG P P +T Q E +S K AP P+ + A +E + + G T
Sbjct: 3367 TGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTTPAP-PTTTSAFVELSTTSHGSPS-STP 3424
Query: 447 NAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEE-------DHRTIYLSSPDSAVGVQW 499
+++ GR T S T P + T Y SSP S + +
Sbjct: 3425 TTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHF 3484
Query: 500 PRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPS 559
P + GEE T++ + S A S + + +E + ++ P S +
Sbjct: 3485 PESDTTSGR--GEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSST 3542
Query: 560 AGGPPVSPLADLSDGSSGGSSIGPQPPS------QGPADPAPSCRTNGVAISDPSRCPQP 613
G A S + G+ + P + + P S A+ + P
Sbjct: 3543 TSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGL 3602
Query: 614 AASSASEQRRPRFQAGTWS----RQCRIEEEEEVEQE------------------LLSHS 651
+ S + PR A T S + EE L HS
Sbjct: 3603 SEKSTTFHSSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSRHS 3662
Query: 652 WGRETKNGPTDHS----NSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAFEFPKDRSGIE 707
+ G TD + ++TT + S + T +S ++ A F ++ +
Sbjct: 3663 TTSHSSPGSTDTTLLPASTTTSGSSQESTTSHSSSGSTDTALSPGSTTALSFGQESTTFH 3722
Query: 708 TFSPP-------PPPPKSRHLLKMNK---SSSDLEKVSQGSAESLSPSFRGVHVSFTT-- 755
+ SP P S +++ + SS+ + + A S SP +G +F T
Sbjct: 3723 S-SPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHP 3781
Query: 756 GSTDSLASDSRTCS-------------DGGPSSELAHSPTNSGKK----LFAPVPFPSGS 798
ST + S T + P++ S T SG +F P SG+
Sbjct: 3782 ASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGT 3841
Query: 799 TEDVSPS---------------GPQQPPPLPQKKIVSRAASSPDGFFWTQGSP------- 836
T + S G + LP + + F+ + SP
Sbjct: 3842 TPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPA 3901
Query: 837 ----------------KPGTASPKLNLSHSET-NVHDESHFSYSLSPGNRHHPVF--SSS 877
+PG+ ++ + + T + +ES YS SPG+ VF S++
Sbjct: 3902 SMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRSTT 3961
Query: 878 DPLEKAFKGSGHWLPA-------------AGLAGNRGGC-GSPGLQCKGAP----SASSS 919
+ + + H PA +GL GSP G P +A
Sbjct: 3962 TSVRREEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLG 4021
Query: 920 QLSVSSQASTGSTQLQLHGLLSNISSKEG 948
+ S + +S+GST +L S S G
Sbjct: 4022 EESTTFPSSSGSTGTKLSPARSTTSGLVG 4050
Score = 33.1 bits (74), Expect = 1.9
Identities = 88/417 (21%), Positives = 138/417 (33%), Gaps = 45/417 (10%)
Query: 468 VSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESH 527
VS T + P H + PDS + + +S G +T+ G ++ S
Sbjct: 304 VSEKSTTSHSRPGPTHTIAF---PDSTTMPGVSQESTASHSIPGSTDTTLSPGTTTPSSL 360
Query: 528 AHSAS--ESKP--KERPAIPPKLSKSS--PVGSPVSPSAGGPPVSPLADLSDGSSGGSSI 581
++ S P + +P + S +PV S G P + S G +
Sbjct: 361 GPESTTFHSSPGYTKTTRLPDNTTTSGLLEASTPVHSSTGSPHTTLSPSSSTTHEGEPTT 420
Query: 582 GPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEEEE 641
PS PAPS T+ + SS S F A + + E
Sbjct: 421 FQSWPSSKDTSPAPSGTTSAFV-----KLSTTYHSSPSSTPTTHFSASSTTLGHSEESTP 475
Query: 642 EVEQELLSHSWGRETKNGPTDH-SNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAFEFP 700
+ + + ++ + H ST +HR S G + S + S E
Sbjct: 476 VHSSPVATATTPPPARSATSGHVEESTAYHR------SPGSTQTMHFPESSTTSGHSEES 529
Query: 701 KDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGSTDS 760
G T + P + L + SS + +S + S R + S D+
Sbjct: 530 ATFHGSTTHTKSSTPSTTAALAHTSYHSSLGSTETTHFRDSSTISGRSEESKASHSSPDA 589
Query: 761 LASDSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGPQQPPPLPQKKIVS 820
+A + G S L T P P SGS E + G P L +K
Sbjct: 590 MA--TTVLPAGSTPSVLVGDST--------PSPISSGSMETTALPGSTTKPGLSEKSTT- 638
Query: 821 RAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHHPVFSSS 877
F+ + SP + L S + + V +ES S+S PG+ H F S
Sbjct: 639 --------FYSSPRSPD----TTHLPASMTSSGVSEESTTSHS-RPGSTHTTAFPGS 682
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 50.1 bits (118), Expect = 2e-05
Identities = 144/657 (21%), Positives = 234/657 (35%), Gaps = 112/657 (17%)
Query: 347 SGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLT---GEPQPPAH--P 401
+G+ AS E D S +E + +++ P + ++ G T G PA P
Sbjct: 246 AGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESP 305
Query: 402 REATQPEP--------IYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKA 453
R+ P P A++ KR++ + S ++ E A AQ + +G A +A
Sbjct: 306 RKGAAPAPPGKTGPAVAKAQAGKREEDSQ-SSSEESDSEEEAPAQAKP---SGKAPQVRA 361
Query: 454 ASGWGRDSP-------DPTPQVSATITVMAAHPEEDHRTIYLSS---------------- 490
AS ++SP P A V EED R+ S
Sbjct: 362 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 421
Query: 491 ---------PDSAVGVQWPRGPVSQNS------EVGEEETSA--GQGLSSRESHAHSASE 533
P S +G+ GP+ + + +VG SA G+ ES + +S+
Sbjct: 422 PLGKSPQVKPASTMGM----GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 477
Query: 534 SKPKERP-AIPPKLSKSSP---VGSPVSPSAGGPP--VSPLA-------DLSDGSSGGSS 580
S E P A+ P KS P S A GPP P+A + + S S
Sbjct: 478 SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEES 537
Query: 581 IGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEEE 640
+ PA + + I CP+ ++AS + P + GT Q +
Sbjct: 538 SDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP-VRVGT---QAPRKAG 593
Query: 641 EEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDG---SSGQNSKVGTGMS-KSASFA 696
S + T+ D S+S G + GQ VG G+ K+AS
Sbjct: 594 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 653
Query: 697 FEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTG 756
+ + P ++ + + S E+ S + SP+ V T
Sbjct: 654 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 713
Query: 757 STDSLASDSRTC-----SDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGPQQPP 811
+ A+ + + + G + A + S K+ PV P ST V GP P
Sbjct: 714 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNST--VLARGPASVP 771
Query: 812 PLPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHH 871
+ K V+ AA + G P+ + S S E++ +E+ + P + H
Sbjct: 772 SV--GKAVATAAQAQTG-------PEEDSGS-----SEEESDSEEEAETLAQVKPSGKTH 817
Query: 872 PVFSSSDPL-EKAFKGS-----GHWLPAAGLAGNRGGCGSPGLQCKG---APSASSS 919
+ ++ P E KG+ G P+A AG + GS + AP+A +S
Sbjct: 818 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 874
Score = 45.8 bits (107), Expect = 3e-04
Identities = 195/944 (20%), Positives = 305/944 (32%), Gaps = 141/944 (14%)
Query: 49 PRAGSLPPPPR-LPPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSSEASDVWTEANLSAE 107
PR G+ P PPR P ++ + +S SSE SD EA +
Sbjct: 370 PRKGAAPAPPRKTGPAAAQVQVGKQEEDS-------------RSSSEESDSDREALAAMN 416
Query: 108 VSQVIWRRAPGKLPLPKQEDAPVVYLGSFRGVQKPAGPSTSPDGNSRCPPAYTMVGLHNL 167
+QV + GK P K P +G P G P + PA +
Sbjct: 417 AAQV---KPLGKSPQVK----PASTMG-----MGPLGKGAGPVPPGKVGPATPSAQVGKW 464
Query: 168 EPRGERNIAFHPVSFPEEKAVHKEKPSFPYQDRPSTQESFRQKLAA--FAGTTSGCHQGP 225
E E + E++ P P+ ++S L A + G Q
Sbjct: 465 EEDSESS---------SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA 515
Query: 226 GPLRESLPSE-----DDSDQRCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGRHG 280
GP+ + +E +S + S S DSE E + + P K A + +
Sbjct: 516 GPVAVQVKAEKPMDNSESSEESSDSADSE--EAPAAMTAAQAKPALKIPQTKACPKKTNT 573
Query: 281 GRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDG 340
G Q R P P + S +SE + S+
Sbjct: 574 TASAKVAPVRVG------TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES-DSEE 626
Query: 341 LSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPAH 400
G G + L+ S+ + + + P PG T + E Q +
Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 686
Query: 401 PREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD 460
E A S + K + ++++A A A +G + AA R
Sbjct: 687 SSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRS 746
Query: 461 SPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQG 520
P V + T+ P S V +Q EE++ + +
Sbjct: 747 PSKVKPPVR----------NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEE 796
Query: 521 LSSRESHAHSASESKP-----KERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGS 575
S E A + ++ KP + R A+ P +P P GP + D
Sbjct: 797 ESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDD-- 854
Query: 576 SGGSSIGPQPPSQGPADPAPSCRTNGVAIS------DPSRCPQ-PAAS-----SASEQRR 623
SG SS + S G AP+ T+ I DP+R P PAA+ +AS R+
Sbjct: 855 SGSSS--EESDSDG---EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRK 909
Query: 624 PRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNS 683
R T E+E+V + G T N T HP + + S
Sbjct: 910 ARASESTARSSSSESEDEDVIPATQCLTPGIRT--------NVVTMPTAHPR--IAPKAS 959
Query: 684 KVGTGMSKSASFAFEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLS 743
G SK +S + K P ++ + + + L+ ++Q ++E+
Sbjct: 960 MAGASSSKESSRISDGKKQEG-------PATQVSKKNPASLPLTQAALKVLAQKASEAQP 1012
Query: 744 PSFRGVHVSFTTGSTDSL-ASDSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDV 802
P R S + +L A+ ++ S + P + P S +ED
Sbjct: 1013 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDS 1072
Query: 803 SPS---------GPQ---------QPPPLPQKKIVSRAA--SSPDGFFWTQGSPKPGTAS 842
S S GPQ P P + +V A SS D S G +
Sbjct: 1073 SDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMT 1132
Query: 843 PKLNLSHSETNVHDESHFSYSLSPGNRHHPVFSSSDPLEKAFKGSGHWLP--AAGLAGNR 900
P L ++S+ + +P P SS+ + G P AAG+
Sbjct: 1133 PGLTPANSQAS---------KATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGML--- 1180
Query: 901 GGCGSPGLQCKGAPSASSSQLSVSSQASTGSTQLQLHGLLSNIS 944
SP K A S ++ Q S + G+ Q L SNI+
Sbjct: 1181 ----SPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNIT 1220
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 50.1 bits (118), Expect = 2e-05
Identities = 144/657 (21%), Positives = 234/657 (35%), Gaps = 112/657 (17%)
Query: 347 SGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLT---GEPQPPAH--P 401
+G+ AS E D S +E + +++ P + ++ G T G PA P
Sbjct: 323 AGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESP 382
Query: 402 REATQPEP--------IYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKA 453
R+ P P A++ KR++ + S ++ E A AQ + +G A +A
Sbjct: 383 RKGAAPAPPGKTGPAVAKAQAGKREEDSQ-SSSEESDSEEEAPAQAKP---SGKAPQVRA 438
Query: 454 ASGWGRDSP-------DPTPQVSATITVMAAHPEEDHRTIYLSS---------------- 490
AS ++SP P A V EED R+ S
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 491 ---------PDSAVGVQWPRGPVSQNS------EVGEEETSA--GQGLSSRESHAHSASE 533
P S +G+ GP+ + + +VG SA G+ ES + +S+
Sbjct: 499 PLGKSPQVKPASTMGM----GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 554
Query: 534 SKPKERP-AIPPKLSKSSP---VGSPVSPSAGGPP--VSPLA-------DLSDGSSGGSS 580
S E P A+ P KS P S A GPP P+A + + S S
Sbjct: 555 SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEES 614
Query: 581 IGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEEE 640
+ PA + + I CP+ ++AS + P + GT Q +
Sbjct: 615 SDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP-VRVGT---QAPRKAG 670
Query: 641 EEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDG---SSGQNSKVGTGMS-KSASFA 696
S + T+ D S+S G + GQ VG G+ K+AS
Sbjct: 671 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 730
Query: 697 FEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTG 756
+ + P ++ + + S E+ S + SP+ V T
Sbjct: 731 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 790
Query: 757 STDSLASDSRTC-----SDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGPQQPP 811
+ A+ + + + G + A + S K+ PV P ST V GP P
Sbjct: 791 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNST--VLARGPASVP 848
Query: 812 PLPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHH 871
+ K V+ AA + G P+ + S S E++ +E+ + P + H
Sbjct: 849 SV--GKAVATAAQAQTG-------PEEDSGS-----SEEESDSEEEAETLAQVKPSGKTH 894
Query: 872 PVFSSSDPL-EKAFKGS-----GHWLPAAGLAGNRGGCGSPGLQCKG---APSASSS 919
+ ++ P E KG+ G P+A AG + GS + AP+A +S
Sbjct: 895 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 951
Score = 42.7 bits (99), Expect = 0.002
Identities = 171/817 (20%), Positives = 264/817 (32%), Gaps = 112/817 (13%)
Query: 49 PRAGSLPPPPR-LPPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSSEASDVWTEANLSAE 107
PR G+ P PPR P ++ + +S SSE SD EA +
Sbjct: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDS-------------RSSSEESDSDREALAAMN 493
Query: 108 VSQVIWRRAPGKLPLPKQEDAPVVYLGSFRGVQKPAGPSTSPDGNSRCPPAYTMVGLHNL 167
+QV + GK P K P +G P G P + PA +
Sbjct: 494 AAQV---KPLGKSPQVK----PASTMG-----MGPLGKGAGPVPPGKVGPATPSAQVGKW 541
Query: 168 EPRGERNIAFHPVSFPEEKAVHKEKPSFPYQDRPSTQESFRQKLAA--FAGTTSGCHQGP 225
E E + E++ P P+ ++S L A + G Q
Sbjct: 542 EEDSESS---------SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA 592
Query: 226 GPLRESLPSE-----DDSDQRCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGRHG 280
GP+ + +E +S + S S DSE E + + P K A + +
Sbjct: 593 GPVAVQVKAEKPMDNSESSEESSDSADSE--EAPAAMTAAQAKPALKIPQTKACPKKTNT 650
Query: 281 GRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDG 340
G Q R P P + S +SE + S+
Sbjct: 651 TASAKVAPVRVG------TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES-DSEE 703
Query: 341 LSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPAH 400
G G + L+ S+ + + + P PG T + E Q +
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 763
Query: 401 PREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD 460
E A S + K + ++++A A A +G + AA R
Sbjct: 764 SSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRS 823
Query: 461 SPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQG 520
P V + T+ P S V +Q EE++ + +
Sbjct: 824 PSKVKPPVR----------NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEE 873
Query: 521 LSSRESHAHSASESKP-----KERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGS 575
S E A + ++ KP + R A+ P +P P GP + D
Sbjct: 874 ESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDD-- 931
Query: 576 SGGSSIGPQPPSQGPADPAPSCRTNGVAIS------DPSRCPQ-PAAS-----SASEQRR 623
SG SS + S G AP+ T+ I DP+R P PAA+ +AS R+
Sbjct: 932 SGSSS--EESDSDG---EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRK 986
Query: 624 PRFQAGTWSRQCRIEEEEEV--EQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQ 681
R T E+E+V + L+ PT H + SS +
Sbjct: 987 ARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGA-SSSKE 1045
Query: 682 NSKVGTGMSKSASFAFEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAES 741
+S++ G K A + + SP +++ K+ K L +V Q +
Sbjct: 1046 SSRISDG-KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPK--LPEVQQATKAP 1102
Query: 742 LSPSFRGVHVSFTTGSTDSLASDSRTCSDG-GP-SSELAHS---PTNSGKKLFAPVPFPS 796
S + S DS S S + DG GP ++ AH+ PT S +
Sbjct: 1103 ES----------SDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAE 1152
Query: 797 GSTEDVSP------SGPQQPPPLPQKKIVSRAASSPD 827
S +DV SG P P S+A D
Sbjct: 1153 SSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLD 1189
Score = 37.4 bits (85), Expect = 0.10
Identities = 50/197 (25%), Positives = 81/197 (41%), Gaps = 24/197 (12%)
Query: 403 EATQPEPIYAESTKRKKAAPVPS--KSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD 460
E + P A + A +PS K +AK E A + G A + A+
Sbjct: 97 ETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGK-TGNSMPHPATGKTVANLLSGK 155
Query: 461 SPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQG 520
SP + + SA T+++ EE S P A G G VS AGQ
Sbjct: 156 SPRKSAEPSANTTLVSETEEEG------SVP--AFGAAAKPGMVS-----------AGQA 196
Query: 521 LSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPS-AGGPPVSPLADLSDGSSGGS 579
SS E + S+ E+ + +P++ P K+S V + SP+ P + D++ GG
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGG- 255
Query: 580 SIGPQPPSQGPADPAPS 596
++ P ++ P + + S
Sbjct: 256 ALPPAKRAKKPEEESES 272
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 50.1 bits (118), Expect = 2e-05
Identities = 144/657 (21%), Positives = 234/657 (35%), Gaps = 112/657 (17%)
Query: 347 SGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLT---GEPQPPAH--P 401
+G+ AS E D S +E + +++ P + ++ G T G PA P
Sbjct: 323 AGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESP 382
Query: 402 REATQPEP--------IYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKA 453
R+ P P A++ KR++ + S ++ E A AQ + +G A +A
Sbjct: 383 RKGAAPAPPGKTGPAVAKAQAGKREEDSQ-SSSEESDSEEEAPAQAKP---SGKAPQVRA 438
Query: 454 ASGWGRDSP-------DPTPQVSATITVMAAHPEEDHRTIYLSS---------------- 490
AS ++SP P A V EED R+ S
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 491 ---------PDSAVGVQWPRGPVSQNS------EVGEEETSA--GQGLSSRESHAHSASE 533
P S +G+ GP+ + + +VG SA G+ ES + +S+
Sbjct: 499 PLGKSPQVKPASTMGM----GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 554
Query: 534 SKPKERP-AIPPKLSKSSP---VGSPVSPSAGGPP--VSPLA-------DLSDGSSGGSS 580
S E P A+ P KS P S A GPP P+A + + S S
Sbjct: 555 SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEES 614
Query: 581 IGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEEE 640
+ PA + + I CP+ ++AS + P + GT Q +
Sbjct: 615 SDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP-VRVGT---QAPRKAG 670
Query: 641 EEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDG---SSGQNSKVGTGMS-KSASFA 696
S + T+ D S+S G + GQ VG G+ K+AS
Sbjct: 671 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 730
Query: 697 FEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTG 756
+ + P ++ + + S E+ S + SP+ V T
Sbjct: 731 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 790
Query: 757 STDSLASDSRTC-----SDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGPQQPP 811
+ A+ + + + G + A + S K+ PV P ST V GP P
Sbjct: 791 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNST--VLARGPASVP 848
Query: 812 PLPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHH 871
+ K V+ AA + G P+ + S S E++ +E+ + P + H
Sbjct: 849 SV--GKAVATAAQAQTG-------PEEDSGS-----SEEESDSEEEAETLAQVKPSGKTH 894
Query: 872 PVFSSSDPL-EKAFKGS-----GHWLPAAGLAGNRGGCGSPGLQCKG---APSASSS 919
+ ++ P E KG+ G P+A AG + GS + AP+A +S
Sbjct: 895 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 951
Score = 46.2 bits (108), Expect = 2e-04
Identities = 195/943 (20%), Positives = 305/943 (32%), Gaps = 140/943 (14%)
Query: 49 PRAGSLPPPPR-LPPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSSEASDVWTEANLSAE 107
PR G+ P PPR P ++ + +S SSE SD EA +
Sbjct: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDS-------------RSSSEESDSDREALAAMN 493
Query: 108 VSQVIWRRAPGKLPLPKQEDAPVVYLGSFRGVQKPAGPSTSPDGNSRCPPAYTMVGLHNL 167
+QV + GK P K P +G P G P + PA +
Sbjct: 494 AAQV---KPLGKSPQVK----PASTMG-----MGPLGKGAGPVPPGKVGPATPSAQVGKW 541
Query: 168 EPRGERNIAFHPVSFPEEKAVHKEKPSFPYQDRPSTQESFRQKLAA--FAGTTSGCHQGP 225
E E + E++ P P+ ++S L A + G Q
Sbjct: 542 EEDSESS---------SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA 592
Query: 226 GPLRESLPSE-----DDSDQRCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGRHG 280
GP+ + +E +S + S S DSE E + + P K A + +
Sbjct: 593 GPVAVQVKAEKPMDNSESSEESSDSADSE--EAPAAMTAAQAKPALKIPQTKACPKKTNT 650
Query: 281 GRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDG 340
G Q R P P + S +SE + S+
Sbjct: 651 TASAKVAPVRVG------TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES-DSEE 703
Query: 341 LSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPAH 400
G G + L+ S+ + + + P PG T + E Q +
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 763
Query: 401 PREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD 460
E A S + K + ++++A A A +G + AA R
Sbjct: 764 SSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRS 823
Query: 461 SPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQG 520
P V + T+ P S V +Q EE++ + +
Sbjct: 824 PSKVKPPVR----------NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEE 873
Query: 521 LSSRESHAHSASESKP-----KERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGS 575
S E A + ++ KP + R A+ P +P P GP + D
Sbjct: 874 ESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDD-- 931
Query: 576 SGGSSIGPQPPSQGPADPAPSCRTNGVAIS------DPSRCPQ-PAAS-----SASEQRR 623
SG SS + S G AP+ T+ I DP+R P PAA+ +AS R+
Sbjct: 932 SGSSS--EESDSDG---EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRK 986
Query: 624 PRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNS 683
R T E+E+V + G T N T HP + + S
Sbjct: 987 ARASESTARSSSSESEDEDVIPATQCLTPGIRT--------NVVTMPTAHPR--IAPKAS 1036
Query: 684 KVGTGMSKSASFAFEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLS 743
G SK +S + K P ++ + + + L+ ++Q ++E+
Sbjct: 1037 MAGASSSKESSRISDGKKQEG-------PATQVSKKNPASLPLTQAALKVLAQKASEAQP 1089
Query: 744 PSFRGVHVSFTTGSTDSL-ASDSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDV 802
P R S + +L A+ ++ S + P + P S +ED
Sbjct: 1090 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDS 1149
Query: 803 SPS---------GPQ--------QPPPLPQKKIVSRAA--SSPDGFFWTQGSPKPGTASP 843
S S GPQ P P + +V A SS D S G +P
Sbjct: 1150 SDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTP 1209
Query: 844 KLNLSHSETNVHDESHFSYSLSPGNRHHPVFSSSDPLEKAFKGSGHWLP--AAGLAGNRG 901
L ++S+ + +P P SS+ + G P AAG+
Sbjct: 1210 GLTPANSQAS---------KATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGML---- 1256
Query: 902 GCGSPGLQCKGAPSASSSQLSVSSQASTGSTQLQLHGLLSNIS 944
SP K A S ++ Q S + G+ Q L SNI+
Sbjct: 1257 ---SPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNIT 1296
Score = 37.4 bits (85), Expect = 0.10
Identities = 50/197 (25%), Positives = 81/197 (41%), Gaps = 24/197 (12%)
Query: 403 EATQPEPIYAESTKRKKAAPVPS--KSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD 460
E + P A + A +PS K +AK E A + G A + A+
Sbjct: 97 ETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGK-TGNSMPHPATGKTVANLLSGK 155
Query: 461 SPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQG 520
SP + + SA T+++ EE S P A G G VS AGQ
Sbjct: 156 SPRKSAEPSANTTLVSETEEEG------SVP--AFGAAAKPGMVS-----------AGQA 196
Query: 521 LSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPS-AGGPPVSPLADLSDGSSGGS 579
SS E + S+ E+ + +P++ P K+S V + SP+ P + D++ GG
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGG- 255
Query: 580 SIGPQPPSQGPADPAPS 596
++ P ++ P + + S
Sbjct: 256 ALPPAKRAKKPEEESES 272
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 50.1 bits (118), Expect = 2e-05
Identities = 144/657 (21%), Positives = 234/657 (35%), Gaps = 112/657 (17%)
Query: 347 SGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLT---GEPQPPAH--P 401
+G+ AS E D S +E + +++ P + ++ G T G PA P
Sbjct: 246 AGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESP 305
Query: 402 REATQPEP--------IYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKA 453
R+ P P A++ KR++ + S ++ E A AQ + +G A +A
Sbjct: 306 RKGAAPAPPGKTGPAVAKAQAGKREEDSQ-SSSEESDSEEEAPAQAKP---SGKAPQVRA 361
Query: 454 ASGWGRDSP-------DPTPQVSATITVMAAHPEEDHRTIYLSS---------------- 490
AS ++SP P A V EED R+ S
Sbjct: 362 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 421
Query: 491 ---------PDSAVGVQWPRGPVSQNS------EVGEEETSA--GQGLSSRESHAHSASE 533
P S +G+ GP+ + + +VG SA G+ ES + +S+
Sbjct: 422 PLGKSPQVKPASTMGM----GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 477
Query: 534 SKPKERP-AIPPKLSKSSP---VGSPVSPSAGGPP--VSPLA-------DLSDGSSGGSS 580
S E P A+ P KS P S A GPP P+A + + S S
Sbjct: 478 SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEES 537
Query: 581 IGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEEE 640
+ PA + + I CP+ ++AS + P + GT Q +
Sbjct: 538 SDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP-VRVGT---QAPRKAG 593
Query: 641 EEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDG---SSGQNSKVGTGMS-KSASFA 696
S + T+ D S+S G + GQ VG G+ K+AS
Sbjct: 594 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 653
Query: 697 FEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTG 756
+ + P ++ + + S E+ S + SP+ V T
Sbjct: 654 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 713
Query: 757 STDSLASDSRTC-----SDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGPQQPP 811
+ A+ + + + G + A + S K+ PV P ST V GP P
Sbjct: 714 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNST--VLARGPASVP 771
Query: 812 PLPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHH 871
+ K V+ AA + G P+ + S S E++ +E+ + P + H
Sbjct: 772 SV--GKAVATAAQAQTG-------PEEDSGS-----SEEESDSEEEAETLAQVKPSGKTH 817
Query: 872 PVFSSSDPL-EKAFKGS-----GHWLPAAGLAGNRGGCGSPGLQCKG---APSASSS 919
+ ++ P E KG+ G P+A AG + GS + AP+A +S
Sbjct: 818 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 874
Score = 46.2 bits (108), Expect = 2e-04
Identities = 195/943 (20%), Positives = 305/943 (32%), Gaps = 140/943 (14%)
Query: 49 PRAGSLPPPPR-LPPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSSEASDVWTEANLSAE 107
PR G+ P PPR P ++ + +S SSE SD EA +
Sbjct: 370 PRKGAAPAPPRKTGPAAAQVQVGKQEEDS-------------RSSSEESDSDREALAAMN 416
Query: 108 VSQVIWRRAPGKLPLPKQEDAPVVYLGSFRGVQKPAGPSTSPDGNSRCPPAYTMVGLHNL 167
+QV + GK P K P +G P G P + PA +
Sbjct: 417 AAQV---KPLGKSPQVK----PASTMG-----MGPLGKGAGPVPPGKVGPATPSAQVGKW 464
Query: 168 EPRGERNIAFHPVSFPEEKAVHKEKPSFPYQDRPSTQESFRQKLAA--FAGTTSGCHQGP 225
E E + E++ P P+ ++S L A + G Q
Sbjct: 465 EEDSESS---------SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA 515
Query: 226 GPLRESLPSE-----DDSDQRCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGRHG 280
GP+ + +E +S + S S DSE E + + P K A + +
Sbjct: 516 GPVAVQVKAEKPMDNSESSEESSDSADSE--EAPAAMTAAQAKPALKIPQTKACPKKTNT 573
Query: 281 GRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDG 340
G Q R P P + S +SE + S+
Sbjct: 574 TASAKVAPVRVG------TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES-DSEE 626
Query: 341 LSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPAH 400
G G + L+ S+ + + + P PG T + E Q +
Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 686
Query: 401 PREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD 460
E A S + K + ++++A A A +G + AA R
Sbjct: 687 SSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRS 746
Query: 461 SPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQG 520
P V + T+ P S V +Q EE++ + +
Sbjct: 747 PSKVKPPVR----------NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEE 796
Query: 521 LSSRESHAHSASESKP-----KERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGS 575
S E A + ++ KP + R A+ P +P P GP + D
Sbjct: 797 ESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDD-- 854
Query: 576 SGGSSIGPQPPSQGPADPAPSCRTNGVAIS------DPSRCPQ-PAAS-----SASEQRR 623
SG SS + S G AP+ T+ I DP+R P PAA+ +AS R+
Sbjct: 855 SGSSS--EESDSDG---EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRK 909
Query: 624 PRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNS 683
R T E+E+V + G T N T HP + + S
Sbjct: 910 ARASESTARSSSSESEDEDVIPATQCLTPGIRT--------NVVTMPTAHPR--IAPKAS 959
Query: 684 KVGTGMSKSASFAFEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLS 743
G SK +S + K P ++ + + + L+ ++Q ++E+
Sbjct: 960 MAGASSSKESSRISDGKKQEG-------PATQVSKKNPASLPLTQAALKVLAQKASEAQP 1012
Query: 744 PSFRGVHVSFTTGSTDSL-ASDSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDV 802
P R S + +L A+ ++ S + P + P S +ED
Sbjct: 1013 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDS 1072
Query: 803 SPS---------GPQ--------QPPPLPQKKIVSRAA--SSPDGFFWTQGSPKPGTASP 843
S S GPQ P P + +V A SS D S G +P
Sbjct: 1073 SDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTP 1132
Query: 844 KLNLSHSETNVHDESHFSYSLSPGNRHHPVFSSSDPLEKAFKGSGHWLP--AAGLAGNRG 901
L ++S+ + +P P SS+ + G P AAG+
Sbjct: 1133 GLTPANSQAS---------KATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGML---- 1179
Query: 902 GCGSPGLQCKGAPSASSSQLSVSSQASTGSTQLQLHGLLSNIS 944
SP K A S ++ Q S + G+ Q L SNI+
Sbjct: 1180 ---SPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNIT 1219
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 50.1 bits (118), Expect = 2e-05
Identities = 144/657 (21%), Positives = 234/657 (35%), Gaps = 112/657 (17%)
Query: 347 SGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLT---GEPQPPAH--P 401
+G+ AS E D S +E + +++ P + ++ G T G PA P
Sbjct: 323 AGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESP 382
Query: 402 REATQPEP--------IYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKA 453
R+ P P A++ KR++ + S ++ E A AQ + +G A +A
Sbjct: 383 RKGAAPAPPGKTGPAVAKAQAGKREEDSQ-SSSEESDSEEEAPAQAKP---SGKAPQVRA 438
Query: 454 ASGWGRDSP-------DPTPQVSATITVMAAHPEEDHRTIYLSS---------------- 490
AS ++SP P A V EED R+ S
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 491 ---------PDSAVGVQWPRGPVSQNS------EVGEEETSA--GQGLSSRESHAHSASE 533
P S +G+ GP+ + + +VG SA G+ ES + +S+
Sbjct: 499 PLGKSPQVKPASTMGM----GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 554
Query: 534 SKPKERP-AIPPKLSKSSP---VGSPVSPSAGGPP--VSPLA-------DLSDGSSGGSS 580
S E P A+ P KS P S A GPP P+A + + S S
Sbjct: 555 SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEES 614
Query: 581 IGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIEEE 640
+ PA + + I CP+ ++AS + P + GT Q +
Sbjct: 615 SDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP-VRVGT---QAPRKAG 670
Query: 641 EEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDG---SSGQNSKVGTGMS-KSASFA 696
S + T+ D S+S G + GQ VG G+ K+AS
Sbjct: 671 TATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 730
Query: 697 FEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTG 756
+ + P ++ + + S E+ S + SP+ V T
Sbjct: 731 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA 790
Query: 757 STDSLASDSRTC-----SDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGPQQPP 811
+ A+ + + + G + A + S K+ PV P ST V GP P
Sbjct: 791 KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNST--VLARGPASVP 848
Query: 812 PLPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHH 871
+ K V+ AA + G P+ + S S E++ +E+ + P + H
Sbjct: 849 SV--GKAVATAAQAQTG-------PEEDSGS-----SEEESDSEEEAETLAQVKPSGKTH 894
Query: 872 PVFSSSDPL-EKAFKGS-----GHWLPAAGLAGNRGGCGSPGLQCKG---APSASSS 919
+ ++ P E KG+ G P+A AG + GS + AP+A +S
Sbjct: 895 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 951
Score = 45.4 bits (106), Expect = 4e-04
Identities = 178/873 (20%), Positives = 276/873 (31%), Gaps = 129/873 (14%)
Query: 49 PRAGSLPPPPR-LPPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSSEASDVWTEANLSAE 107
PR G+ P PPR P ++ + +S SSE SD EA +
Sbjct: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDS-------------RSSSEESDSDREALAAMN 493
Query: 108 VSQVIWRRAPGKLPLPKQEDAPVVYLGSFRGVQKPAGPSTSPDGNSRCPPAYTMVGLHNL 167
+QV + GK P K P +G P G P + PA +
Sbjct: 494 AAQV---KPLGKSPQVK----PASTMG-----MGPLGKGAGPVPPGKVGPATPSAQVGKW 541
Query: 168 EPRGERNIAFHPVSFPEEKAVHKEKPSFPYQDRPSTQESFRQKLAA--FAGTTSGCHQGP 225
E E + E++ P P+ ++S L A + G Q
Sbjct: 542 EEDSESS---------SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA 592
Query: 226 GPLRESLPSE-----DDSDQRCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGRHG 280
GP+ + +E +S + S S DSE E + + P K A + +
Sbjct: 593 GPVAVQVKAEKPMDNSESSEESSDSADSE--EAPAAMTAAQAKPALKIPQTKACPKKTNT 650
Query: 281 GRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDG 340
G Q R P P + S +SE + S+
Sbjct: 651 TASAKVAPVRVG------TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES-DSEE 703
Query: 341 LSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPAH 400
G G + L+ S+ + + + P PG T + E Q +
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 763
Query: 401 PREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD 460
E A S + K + ++++A A A +G + AA R
Sbjct: 764 SSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRS 823
Query: 461 SPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQG 520
P V + T+ P S V +Q EE++ + +
Sbjct: 824 PSKVKPPVR----------NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEE 873
Query: 521 LSSRESHAHSASESKP-----KERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGS 575
S E A + ++ KP + R A+ P +P P GP + D
Sbjct: 874 ESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDD-- 931
Query: 576 SGGSSIGPQPPSQGPADPAPSCRTNGVAIS------DPSRCPQ-PAAS-----SASEQRR 623
SG SS + S G AP+ T+ I DP+R P PAA+ +AS R+
Sbjct: 932 SGSSS--EESDSDG---EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRK 986
Query: 624 PRFQAGTWSRQCRIEEEEEV--EQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQ 681
R T E+E+V + L+ PT H + SS +
Sbjct: 987 ARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGA-SSSKE 1045
Query: 682 NSKVGTGMSKSASFAFEFPKDRSGIETFSP--------------PPPPPKSRHLLKMNKS 727
+S++ G K A + + SP P P+ + K +S
Sbjct: 1046 SSRISDG-KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPES 1104
Query: 728 SSDLEKVSQGS--AESLSPSFRGVHVSFTTGSTDS--------LASDSRTCSDGGPSSEL 777
S D E S S +E +G + T G T S A++S PS L
Sbjct: 1105 SDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSL 1164
Query: 778 AH-------SPTNSGKKLFAPVPFPSGSTEDV-----SPSGPQQPPPLPQKKIVSRAASS 825
+P NS P S S P G Q+ P ++S
Sbjct: 1165 LSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGG 1224
Query: 826 PDGFFWT----QGSPKPGTASPKLNLSHSETNV 854
+ T PK G +P+ + ++N+
Sbjct: 1225 KEAASGTTPQKSRKPKKGAGNPQASTLALQSNI 1257
Score = 37.4 bits (85), Expect = 0.10
Identities = 50/197 (25%), Positives = 81/197 (41%), Gaps = 24/197 (12%)
Query: 403 EATQPEPIYAESTKRKKAAPVPS--KSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD 460
E + P A + A +PS K +AK E A + G A + A+
Sbjct: 97 ETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGK-TGNSMPHPATGKTVANLLSGK 155
Query: 461 SPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQG 520
SP + + SA T+++ EE S P A G G VS AGQ
Sbjct: 156 SPRKSAEPSANTTLVSETEEEG------SVP--AFGAAAKPGMVS-----------AGQA 196
Query: 521 LSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPS-AGGPPVSPLADLSDGSSGGS 579
SS E + S+ E+ + +P++ P K+S V + SP+ P + D++ GG
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGG- 255
Query: 580 SIGPQPPSQGPADPAPS 596
++ P ++ P + + S
Sbjct: 256 ALPPAKRAKKPEEESES 272
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 855
Score = 49.7 bits (117), Expect = 2e-05
Identities = 130/556 (23%), Positives = 184/556 (33%), Gaps = 92/556 (16%)
Query: 135 SFRGVQKPAGPSTSP---------DGNSRCPPAYTMVGLHNLEPRGERNIAFHPVS-FPE 184
S RG + P +TSP G +R P +G L E +A + P+
Sbjct: 97 SGRGERAPPAKNTSPGPVSSPGRASGTTRPGP----LGQKGLRISAEETVARGKATEAPK 152
Query: 185 EKAVHKEKPSFPYQDRPSTQESFRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQRCSP 244
A+ P T + + AGT G P P + P R S
Sbjct: 153 RSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL---PRPAPSARPRPPTEGPRKSV 209
Query: 245 SGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGRHGGRDCSP--TCWEQGKCSGP-AEQE 301
S SE SP A+ G R R S T SGP A
Sbjct: 210 SSASEHST-------TEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGT 262
Query: 302 KRGPSFPKECCSQGPTA--HPSCLGPKKLSLTSEAAISSDGLSCGSGSGSGASS-----P 354
R P+ P + +G A P P+K + + +SS L+ S S + S P
Sbjct: 263 PRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLP 322
Query: 355 FVPHLESDYCSL-----MKEPAPEK----QQDPGCPGVTPSRCLGLTGEP---------- 395
PH S C L + P+P Q P P PS+ G P
Sbjct: 323 ATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLP 382
Query: 396 QPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAAS 455
PP P P+ A + +A P P S + A Q NA A
Sbjct: 383 SPPLSPLATPPPQAPPALALPPLQAPPSPPASPP-LSPLATPSPQAP----NALAVHLLQ 437
Query: 456 GWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDS--AVGVQWPRGPVSQNSEVGEE 513
SP P+P V A + A+ P T +P S A +Q P P + + +
Sbjct: 438 A--PFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA-SPPMSPS 494
Query: 514 ETSAGQGLSSRESHAHSASESKPKERPAI--PPKLSKSSPVGS-------------PVSP 558
T Q + ++ P+ PA+ PP + SP S P+SP
Sbjct: 495 ATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 554
Query: 559 SAGGPPVSPLADLSDGSSGGSSIGPQPPS-------QGPADPAPSCRTNGVAIS---DPS 608
A PP +P ++ + P PP+ + P P P +G ++ P
Sbjct: 555 LATPPPQAPPV----LAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPG 610
Query: 609 RCPQPAASSASEQRRP 624
P P+ S +S P
Sbjct: 611 PPPPPSRSPSSTLSGP 626
Score = 46.2 bits (108), Expect = 2e-04
Identities = 80/365 (21%), Positives = 121/365 (33%), Gaps = 62/365 (16%)
Query: 261 PGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAHP 320
P PV AA + G+ G G + + G + P + GP+ S+ P + P
Sbjct: 35 PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRP 94
Query: 321 SCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGC 380
SG G +P P K PG
Sbjct: 95 PA------------------------SGRGERAP-----------------PAKNTSPG- 112
Query: 381 PGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQ 440
P +P R G T P P E E+ R KA P +S G
Sbjct: 113 PVSSPGRASGTT-RPGPLGQKGLRISAE----ETVARGKATEAPKRSALSAGARRDTSGP 167
Query: 441 GQVCTGNAWAQKAAS-----GWGRDSPD-----PTPQVSATITVMAAHPEEDHRTIYLSS 490
A A+++ + G R +P PT +++ + H +
Sbjct: 168 TPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR 227
Query: 491 PDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKSS 550
P + G+Q P S +S + A G S+R + A S+PK + + + +
Sbjct: 228 PSAGGGLQRPASR-SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVT 286
Query: 551 PVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAPSCRTNGVAISDPSRC 610
P +P+ G SPLA S +++ Q P PA P S T +A P
Sbjct: 287 PPRKDAAPALGPLSSSPLAT----PSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAP 342
Query: 611 PQPAA 615
P P+A
Sbjct: 343 PSPSA 347
Score = 43.1 bits (100), Expect = 0.002
Identities = 115/478 (24%), Positives = 174/478 (36%), Gaps = 70/478 (14%)
Query: 208 RQKLAAFAGTTSGC---HQGP--GPLRESLPSEDDSDQRCSPSGDSEGGEYCSILDCCPG 262
R+ LA AG G P GP R + S + R SG E P
Sbjct: 55 RKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPV 114
Query: 263 SPVAKAASQTA-GSRGRHGGRDCSPTCWEQGKC---------SGPAEQEKRGPS--FPKE 310
S +A+ T G G+ G R + +GK S A ++ GP+ P
Sbjct: 115 SSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSP 174
Query: 311 CCSQGPTAHPSCLGPKKLSLTSEAAISSDG----LSCGSGSGSGASSPFVPHLESDYCSL 366
++ A + +G + + ++ ++G +S S + SP S L
Sbjct: 175 AMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGL 234
Query: 367 MKEPAPEKQQDPGCPGVTPSRC-LGLTGEPQPPAHPREATQPEPIYAESTK-------RK 418
+ PA P +P+R G P+ PAHP +QP+P ++ + RK
Sbjct: 235 QR-PASRSLSSSATPLSSPARSGPSARGTPRAPAHP---SQPKPKGLQALRPPQVTPPRK 290
Query: 419 KAAP----VPSKSQAKIEHAAAAQGQG---------------QVCTGNAWAQKAASG--- 456
AAP + S A +AA Q Q Q+ T A + S
Sbjct: 291 DAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPS 350
Query: 457 -WGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEET 515
SP TP AT ++ + + H + S P S + P+ P + +
Sbjct: 351 LQTLPSPPATPPSQATTSLGSPTLQATH-SFLPSPPLSPLATPPPQAPPALALPPLQAPP 409
Query: 516 SAGQG-----LSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLAD 570
S L++ A +A + P PP S PV +P SP A PPVSP A
Sbjct: 410 SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPP---SPPVQAPFSPPAS-PPVSPSA- 464
Query: 571 LSDGSSGGSSIGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQA 628
+ S S+ PP Q P P P+ + + P + P P A+ + +P QA
Sbjct: 465 -TPPSQAPPSLAA-PPLQVPPSP-PASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA 519
Score = 38.1 bits (87), Expect = 0.060
Identities = 94/442 (21%), Positives = 146/442 (33%), Gaps = 47/442 (10%)
Query: 379 GCPGVTPS-RCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAA 437
G TP+ R GL P+PP PR P P+ + + AA + + A
Sbjct: 11 GAAARTPAARAPGLL-TPRPPGSPRP---PPPVTPAALRVLGAAGAVGRKP--LAERAGG 64
Query: 438 QGQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGV 497
G + A S G S +P + A+ A P ++ +SSP A G
Sbjct: 65 IGGATIPESAPRAGPTRSA-GTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGT 123
Query: 498 QWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVS 557
P GP+ Q G +S+ E+ A + PK R A+ + + +P +
Sbjct: 124 TRP-GPLGQK----------GLRISAEETVARGKATEAPK-RSALSAGARRDTSGPTPGT 171
Query: 558 PSAGGPPVSPLADLSDG-SSGGSSIGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAAS 616
PS S A G S P+PP++GP S + P+ +P+A
Sbjct: 172 PSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAG 231
Query: 617 SASEQRRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTT--WHRLHP 674
++ R + + + S R T P S L P
Sbjct: 232 GGLQRPASRSLSSS---------ATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRP 282
Query: 675 TDGSSGQNSKVGTGMSKSASFAFEFPKDRSGIETFSPP--PPPPKSRHLLKMNKSSSDLE 732
+ + + +S P + +++ +PP P P S L + L
Sbjct: 283 PQVTPPRKD-AAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLA 341
Query: 733 KVSQGSAESLSPSFRGVHVSFTTGSTDSLASDSRTCSDGGPSSELAHSPTNSGKKLFAPV 792
S + SL T S + T S G P+ + HS S +P+
Sbjct: 342 PPSPSAPPSLQ----------TLPSPPATPPSQATTSLGSPTLQATHSFLPSPP--LSPL 389
Query: 793 PFPSGSTEDVSPSGPQQPPPLP 814
P P Q PP P
Sbjct: 390 ATPPPQAPPALALPPLQAPPSP 411
Score = 37.7 bits (86), Expect = 0.078
Identities = 28/93 (30%), Positives = 37/93 (39%), Gaps = 4/93 (4%)
Query: 1155 TLQAG----PGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGPREKQLPRLII 1210
TLQA P P +P P APP + P PA+ P SP Q P +
Sbjct: 373 TLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALA 432
Query: 1211 SNFLKAKQKPGGTPNLQQKKSQARLAPEIVSAS 1243
+ L+A P +P +Q S P SA+
Sbjct: 433 VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT 465
Score = 34.7 bits (78), Expect = 0.66
Identities = 37/107 (34%), Positives = 45/107 (42%), Gaps = 18/107 (16%)
Query: 1148 NLLLVHCTLQAGPGPAPAP---APAPAAAAPPCS-SAAPPAGGTLS------------PA 1191
N L VH LQA P P+P AP A+PP S SA PP+ S PA
Sbjct: 429 NALAVHL-LQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA 487
Query: 1192 AGPASPEGPREKQLPRLIISNFLK-AKQKPGGTPNLQQKKSQARLAP 1237
+ P SP Q P + + L+ AK P P L QA +P
Sbjct: 488 SPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSP 534
Score = 34.7 bits (78), Expect = 0.66
Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 6/81 (7%)
Query: 1164 PAPAPAPAAAAPPCSSA-APPAG----GTLSPAAG-PASPEGPREKQLPRLIISNFLKAK 1217
P P PA A PP + +PPA SP+A P SP Q P ++ + L+
Sbjct: 515 PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVP 574
Query: 1218 QKPGGTPNLQQKKSQARLAPE 1238
P +P LQ + P+
Sbjct: 575 PSPPASPTLQAPRRPPTPGPD 595
Score = 32.7 bits (73), Expect = 2.5
Identities = 62/246 (25%), Positives = 88/246 (35%), Gaps = 46/246 (18%)
Query: 710 SPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGST--DSLASDSRT 767
SP PPPP + L++ G+A ++ G+T +S T
Sbjct: 32 SPRPPPPVTPAALRV-----------LGAAGAVGRKPLAERAGGIGGATIPESAPRAGPT 80
Query: 768 CSDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSP----SGPQQPPPLPQKKIV---- 819
S G S A P SG+ AP P + S VS SG +P PL QK +
Sbjct: 81 RSAGTSSRNPASRPPASGRGERAP-PAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAE 139
Query: 820 -----SRAASSPDGFFWTQGS------PKPGTASPKL----NLSHSETNVHDESHFSYSL 864
+A +P + G+ P PGT SP + + +E + +
Sbjct: 140 ETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPA------ 193
Query: 865 SPGNRHHPVFSSSDPLEKAFKGSGHWLPAAGLAGNRGGCGSPGLQCKGAPSASSSQLSVS 924
P R P + P + S H A R GLQ + S SSS +S
Sbjct: 194 -PSARPRP--PTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLS 250
Query: 925 SQASTG 930
S A +G
Sbjct: 251 SPARSG 256
Score = 30.8 bits (68), Expect = 9.6
Identities = 26/103 (25%), Positives = 37/103 (35%), Gaps = 16/103 (15%)
Query: 1156 LQAGPGPAPAPAPAPAAAAPPCSSAA---------------PPAGGTLSPAAGP-ASPEG 1199
LQA P P +P +P A P + A PP SP A P SP
Sbjct: 405 LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA 464
Query: 1200 PREKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSA 1242
Q P + + L+ P +P + + AP ++A
Sbjct: 465 TPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAA 507
>gi|21264565 AT rich interactive domain 1A isoform a [Homo sapiens]
Length = 2285
Score = 49.7 bits (117), Expect = 2e-05
Identities = 95/376 (25%), Positives = 136/376 (36%), Gaps = 53/376 (14%)
Query: 261 PGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAHP 320
P S + KA Q R GG + E+G+ A QE GP+ GP
Sbjct: 20 PPSELKKAEQQ---QREEAGGEAAAAAAAERGEMKAAAGQESEGPAV-------GP---- 65
Query: 321 SCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQ--QDP 378
P+ L + S+G G G+GSG P L++ + PA + P
Sbjct: 66 ----PQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLTEPP 121
Query: 379 GCPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQ 438
G G S +G P H A P P Y ++ + + A + H Q
Sbjct: 122 GGGGGGSSDGVG------APPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFH---QQ 172
Query: 439 GQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEEDH---RTIYLSSPDSAV 495
GQ G A Q + G G P PQ ++ H + R+ Y P A
Sbjct: 173 HGGQQSPGLAALQ--SGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAY-PPPAPAY 229
Query: 496 GVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSP 555
+ PRG + G + + S + A S+S S ++R S+ G
Sbjct: 230 ALSSPRGGTPGS---GAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGT 286
Query: 556 VSPSAGGPPVSPL------ADLSDGSSGGS-SIGPQP--PSQGPADPAPSCRTNGVAISD 606
P+A P ++ L A G GG S GPQ +GPAD A C A +
Sbjct: 287 PQPTA-TPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAA 345
Query: 607 PSRCPQPAASSASEQR 622
+ AAS ++QR
Sbjct: 346 AA-----AASGGAQQR 356
Score = 46.6 bits (109), Expect = 2e-04
Identities = 82/352 (23%), Positives = 136/352 (38%), Gaps = 58/352 (16%)
Query: 285 SPTCWEQGKCSGPAEQEKRGPSFPKECC-SQGPTAHPSCLGPKKLS----LTSEAAISSD 339
+P +QG SGP ++G +P + SQ P +P + + S L+ I
Sbjct: 399 NPYSQQQGPPSGP----QQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPPY 454
Query: 340 GLSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGC---PGVTPSRCLGLTGEPQ 396
G SG G +P+ + P P++QQ P P TP + Q
Sbjct: 455 GQQGPSGYGQQGQTPYYNQ---------QSPHPQQQQPPYSQQPPSQTPHAQPSY--QQQ 503
Query: 397 PPAHPREATQPEPIYAESTKR----KKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQK 452
P + P + +P Y++ + + AP PS+ +H + Q + + Q+
Sbjct: 504 PQSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQ 563
Query: 453 AASGWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQW--PRGPVSQNSEV 510
P +T++ AA+P+ + S +A Q P +SQ+S
Sbjct: 564 ----------QPQQPAPSTLSQQAAYPQPQSQ----QSQQTAYSQQRFPPPQELSQDS-F 608
Query: 511 GEEETSAGQGLSSR--ESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPL 568
G + +SA SS+ + + + +S+P P + + P+G+ A P VS
Sbjct: 609 GSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSID-DLPMGTE---GALSPGVST- 663
Query: 569 ADLSDGSSGGSSIGPQP-PSQGPADPAPSCRTNGVAISDPSRCPQPAASSAS 619
S SS G Q P+Q P P S G+ PS PA+ + S
Sbjct: 664 ------SGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQS 709
Score = 38.9 bits (89), Expect = 0.035
Identities = 125/625 (20%), Positives = 207/625 (33%), Gaps = 128/625 (20%)
Query: 375 QQDPGCPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHA 434
QQ PG + GL P + + P Y + A P P+ + A
Sbjct: 176 QQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPR 235
Query: 435 AAAQGQGQVC----------------TGNAWAQKAASGWGRDSPDP----TPQVSATITV 474
G G + +++AQ+ G P TPQ +AT T+
Sbjct: 236 GGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTL 295
Query: 475 MAAHPEEDHRTIYLSSPDSAVGVQ-WPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASE 533
L+SP SA G Q +P G S G ++ AG+G + S A+
Sbjct: 296 NQL----------LTSPSSARGYQGYPGGDYSG----GPQDGGAGKGPADMASQCWGAAA 341
Query: 534 SKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIG---PQP----- 585
+ A +S +P+SP + G PLA SS +G PQP
Sbjct: 342 AAAAAAAASGGAQQRSHH--APMSPGSSGGGGQPLARTPQPSSPMDQMGKMRPQPYGGTN 399
Query: 586 -----------PSQG---PADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRF----- 626
P QG P P S ++ R + Q+ P +
Sbjct: 400 PYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPPYGQQGP 459
Query: 627 -------QAGTWSRQCRIEEEEE-----------------VEQELLSHSWGRETKNGPTD 662
Q +++Q ++++ +Q+ S ++ P
Sbjct: 460 SGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQSSQPPYS 519
Query: 663 HSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAFEFPKDRSGIETFSPPPPPPKSRHLL 722
S H+ P S Q++ T + + P+ +S + P P P +
Sbjct: 520 QQPSQPPHQQSPAPYPSQQST---TQQHPQSQPPYSQPQAQSPYQQQQPQQPAPST---- 572
Query: 723 KMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGSTDSLASDSRTCSDGGPSSELAHSPT 782
+++ ++ + SQ S + T + + S S+ + +P+
Sbjct: 573 -LSQQAAYPQPQSQQSQQ--------------TAYSQQRFPPPQELSQDSFGSQASSAPS 617
Query: 783 NSGKKLFAPVPFPSGSTEDVSPSGPQQPPPLPQKKIVSRAASSPDGFFWTQGSPKPGTAS 842
+ K G ED++ S +P LP + S D T+G+ PG ++
Sbjct: 618 MTSSK---------GGQEDMNLSLQSRPSSLP-----DLSGSIDDLPMGTEGALSPGVST 663
Query: 843 PKLNLSHSETNVHDESHFSYSLS---PGNRHHPVFSSSDPLEKAFKGSGHWLPAAGLAGN 899
++ S E + +S FS S PG R P A SG PAA + GN
Sbjct: 664 SGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAA-VPGN 722
Query: 900 RGGCGSPGLQCKGAPSASSSQLSVS 924
+ P Q S +Q S++
Sbjct: 723 QMPPRPPSGQSDSIMHPSMNQSSIA 747
Score = 32.7 bits (73), Expect = 2.5
Identities = 54/250 (21%), Positives = 90/250 (36%), Gaps = 50/250 (20%)
Query: 393 GEPQ----PPAHPREATQPE---PIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCT 445
G+PQ PPA P+ A+Q + P + + P+ + A E A Q Q
Sbjct: 1398 GQPQQQQLPPAQPQPASQQQAAQPSPQQDVYNQYGNAYPATATAATERRPAGGPQNQF-- 1455
Query: 446 GNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWP-RGPV 504
+GRD P +A + P+ I S+ + G W R +
Sbjct: 1456 --------PFQFGRDRVSAPPGTNAQQNMP---PQMMGGPIQASAEVAQQGTMWQGRNDM 1504
Query: 505 SQNSEVGEEETSAGQG-----LSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPS 559
+ N + SA QG ++ + H+ + + + P ++ P G PS
Sbjct: 1505 TYNYANRQSTGSAPQGPAYHGVNRTDEMLHT--DQRANHEGSWPSHGTRQPPYG----PS 1558
Query: 560 AGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAASSAS 619
A PP++ PPS P PS + + +S P+ P+P + S
Sbjct: 1559 APVPPMTR----------------PPPSN--YQPPPSMQNHIPQVSSPAPLPRPMENRTS 1600
Query: 620 EQRRPRFQAG 629
+ P +G
Sbjct: 1601 PSKSPFLHSG 1610
Score = 30.8 bits (68), Expect = 9.6
Identities = 32/115 (27%), Positives = 42/115 (36%), Gaps = 13/115 (11%)
Query: 504 VSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKL------SKSSPVGSPVS 557
++ N VG +SA L + A E K + PP + KS P P S
Sbjct: 1076 LATNLNVGTS-SSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPS 1134
Query: 558 PSAGGPPVSPLADLSDGSS--GGSSIGPQPPSQGPADPAP----SCRTNGVAISD 606
P+ G P S SS G + P P+ P P R+N V I D
Sbjct: 1135 PAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQD 1189
>gi|21264575 AT rich interactive domain 1A isoform b [Homo sapiens]
Length = 2068
Score = 49.7 bits (117), Expect = 2e-05
Identities = 95/376 (25%), Positives = 136/376 (36%), Gaps = 53/376 (14%)
Query: 261 PGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAHP 320
P S + KA Q R GG + E+G+ A QE GP+ GP
Sbjct: 20 PPSELKKAEQQ---QREEAGGEAAAAAAAERGEMKAAAGQESEGPAV-------GP---- 65
Query: 321 SCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQ--QDP 378
P+ L + S+G G G+GSG P L++ + PA + P
Sbjct: 66 ----PQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLTEPP 121
Query: 379 GCPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQ 438
G G S +G P H A P P Y ++ + + A + H Q
Sbjct: 122 GGGGGGSSDGVG------APPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFH---QQ 172
Query: 439 GQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEEDH---RTIYLSSPDSAV 495
GQ G A Q + G G P PQ ++ H + R+ Y P A
Sbjct: 173 HGGQQSPGLAALQ--SGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAY-PPPAPAY 229
Query: 496 GVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSP 555
+ PRG + G + + S + A S+S S ++R S+ G
Sbjct: 230 ALSSPRGGTPGS---GAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGT 286
Query: 556 VSPSAGGPPVSPL------ADLSDGSSGGS-SIGPQP--PSQGPADPAPSCRTNGVAISD 606
P+A P ++ L A G GG S GPQ +GPAD A C A +
Sbjct: 287 PQPTA-TPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAA 345
Query: 607 PSRCPQPAASSASEQR 622
+ AAS ++QR
Sbjct: 346 AA-----AASGGAQQR 356
Score = 46.6 bits (109), Expect = 2e-04
Identities = 82/352 (23%), Positives = 136/352 (38%), Gaps = 58/352 (16%)
Query: 285 SPTCWEQGKCSGPAEQEKRGPSFPKECC-SQGPTAHPSCLGPKKLS----LTSEAAISSD 339
+P +QG SGP ++G +P + SQ P +P + + S L+ I
Sbjct: 399 NPYSQQQGPPSGP----QQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPPY 454
Query: 340 GLSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGC---PGVTPSRCLGLTGEPQ 396
G SG G +P+ + P P++QQ P P TP + Q
Sbjct: 455 GQQGPSGYGQQGQTPYYNQ---------QSPHPQQQQPPYSQQPPSQTPHAQPSY--QQQ 503
Query: 397 PPAHPREATQPEPIYAESTKR----KKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQK 452
P + P + +P Y++ + + AP PS+ +H + Q + + Q+
Sbjct: 504 PQSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQ 563
Query: 453 AASGWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQW--PRGPVSQNSEV 510
P +T++ AA+P+ + S +A Q P +SQ+S
Sbjct: 564 ----------QPQQPAPSTLSQQAAYPQPQSQ----QSQQTAYSQQRFPPPQELSQDS-F 608
Query: 511 GEEETSAGQGLSSR--ESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPL 568
G + +SA SS+ + + + +S+P P + + P+G+ A P VS
Sbjct: 609 GSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSID-DLPMGTE---GALSPGVST- 663
Query: 569 ADLSDGSSGGSSIGPQP-PSQGPADPAPSCRTNGVAISDPSRCPQPAASSAS 619
S SS G Q P+Q P P S G+ PS PA+ + S
Sbjct: 664 ------SGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQS 709
Score = 38.9 bits (89), Expect = 0.035
Identities = 125/625 (20%), Positives = 207/625 (33%), Gaps = 128/625 (20%)
Query: 375 QQDPGCPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHA 434
QQ PG + GL P + + P Y + A P P+ + A
Sbjct: 176 QQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPR 235
Query: 435 AAAQGQGQVC----------------TGNAWAQKAASGWGRDSPDP----TPQVSATITV 474
G G + +++AQ+ G P TPQ +AT T+
Sbjct: 236 GGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTL 295
Query: 475 MAAHPEEDHRTIYLSSPDSAVGVQ-WPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASE 533
L+SP SA G Q +P G S G ++ AG+G + S A+
Sbjct: 296 NQL----------LTSPSSARGYQGYPGGDYSG----GPQDGGAGKGPADMASQCWGAAA 341
Query: 534 SKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIG---PQP----- 585
+ A +S +P+SP + G PLA SS +G PQP
Sbjct: 342 AAAAAAAASGGAQQRSHH--APMSPGSSGGGGQPLARTPQPSSPMDQMGKMRPQPYGGTN 399
Query: 586 -----------PSQG---PADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRF----- 626
P QG P P S ++ R + Q+ P +
Sbjct: 400 PYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPPYGQQGP 459
Query: 627 -------QAGTWSRQCRIEEEEE-----------------VEQELLSHSWGRETKNGPTD 662
Q +++Q ++++ +Q+ S ++ P
Sbjct: 460 SGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQSSQPPYS 519
Query: 663 HSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAFEFPKDRSGIETFSPPPPPPKSRHLL 722
S H+ P S Q++ T + + P+ +S + P P P +
Sbjct: 520 QQPSQPPHQQSPAPYPSQQST---TQQHPQSQPPYSQPQAQSPYQQQQPQQPAPST---- 572
Query: 723 KMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGSTDSLASDSRTCSDGGPSSELAHSPT 782
+++ ++ + SQ S + T + + S S+ + +P+
Sbjct: 573 -LSQQAAYPQPQSQQSQQ--------------TAYSQQRFPPPQELSQDSFGSQASSAPS 617
Query: 783 NSGKKLFAPVPFPSGSTEDVSPSGPQQPPPLPQKKIVSRAASSPDGFFWTQGSPKPGTAS 842
+ K G ED++ S +P LP + S D T+G+ PG ++
Sbjct: 618 MTSSK---------GGQEDMNLSLQSRPSSLP-----DLSGSIDDLPMGTEGALSPGVST 663
Query: 843 PKLNLSHSETNVHDESHFSYSLS---PGNRHHPVFSSSDPLEKAFKGSGHWLPAAGLAGN 899
++ S E + +S FS S PG R P A SG PAA + GN
Sbjct: 664 SGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAA-VPGN 722
Query: 900 RGGCGSPGLQCKGAPSASSSQLSVS 924
+ P Q S +Q S++
Sbjct: 723 QMPPRPPSGQSDSIMHPSMNQSSIA 747
Score = 30.8 bits (68), Expect = 9.6
Identities = 32/115 (27%), Positives = 42/115 (36%), Gaps = 13/115 (11%)
Query: 504 VSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKL------SKSSPVGSPVS 557
++ N VG +SA L + A E K + PP + KS P P S
Sbjct: 1076 LATNLNVGTS-SSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPS 1134
Query: 558 PSAGGPPVSPLADLSDGSS--GGSSIGPQPPSQGPADPAP----SCRTNGVAISD 606
P+ G P S SS G + P P+ P P R+N V I D
Sbjct: 1135 PAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQD 1189
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
Length = 816
Score = 49.3 bits (116), Expect = 3e-05
Identities = 106/451 (23%), Positives = 167/451 (37%), Gaps = 55/451 (12%)
Query: 208 RQKLAAFAGTTSGC---HQGP--GPLRESLPSEDDSDQRCSPSGDSEGGEYCSILDCCPG 262
R+ LA AG G P GP R S P +R P+ ++ G
Sbjct: 55 RKPLAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPV--------S 106
Query: 263 SPVAKAASQTAGSRGRHGGRDCSPTCWEQGKC---------SGPAEQEKRGPS--FPKEC 311
SP + + G G+ G R + +GK S A ++ GP+ P
Sbjct: 107 SPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPA 166
Query: 312 CSQGPTAHPSCLGPKKLSLTSEAAISSDG----LSCGSGSGSGASSPFVPHLESDYCSLM 367
++ A + +G + + ++ ++G +S S + SP S L
Sbjct: 167 MARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ 226
Query: 368 KEPAPEKQQDPGCPGVTPSRC-LGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSK 426
+ PA P +P+R G P+ PAHP +QP+P ++ + + P P K
Sbjct: 227 R-PASRSLSSSATPLSSPARSGPSARGTPRAPAHP---SQPKPKGLQALRPPQVTP-PRK 281
Query: 427 SQAKIEHAAAAQGQGQVCTGNAWAQKAASG----WGRDSPDPTPQVSATITVMAAHPEED 482
A A + T + A + S SP TP AT ++ + +
Sbjct: 282 DAAP---ALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQAT 338
Query: 483 HRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQG-----LSSRESHAHSASESKPK 537
H + S P S + P+ P + + S L++ A +A
Sbjct: 339 H-SFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLL 397
Query: 538 ERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAPSC 597
+ P PP S PV +P SP A PPVSP A + S S+ PP Q P P P+
Sbjct: 398 QAPFSPPP---SPPVQAPFSPPAS-PPVSPSA--TPPSQAPPSLAA-PPLQVPPSP-PAS 449
Query: 598 RTNGVAISDPSRCPQPAASSASEQRRPRFQA 628
+ + P + P P A+ + +P QA
Sbjct: 450 PPMSPSATPPPQAPPPLAAPPLQLAKPPPQA 480
Score = 44.7 bits (104), Expect = 6e-04
Identities = 125/542 (23%), Positives = 177/542 (32%), Gaps = 94/542 (17%)
Query: 135 SFRGVQKPAGPSTSP---------DGNSRCPPAYTMVGLHNLEPRGERNIAFHPVS-FPE 184
S RG + P +TSP G +R P +G L E +A + P+
Sbjct: 88 SGRGERAPPAKNTSPGPVSSPGRASGTTRPGP----LGQKGLRISAEETVARGKATEAPK 143
Query: 185 EKAVHKEKPSFPYQDRPSTQESFRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQRCSP 244
A+ P T + + AGT G P P + P R S
Sbjct: 144 RSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL---PRPAPSARPRPPTEGPRKSV 200
Query: 245 SGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGRHGGRDCSP--TCWEQGKCSGP-AEQE 301
S SE SP A+ G R R S T SGP A
Sbjct: 201 SSASEHST-------TEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGT 253
Query: 302 KRGPSFPKECCSQGPTA--HPSCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHL 359
R P+ P + +G A P P+K + + +SS L+ + S S SP P
Sbjct: 254 PRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA--TPSPSAPPSPSAP-- 309
Query: 360 ESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEP----------QPPAHPREATQPEP 409
P Q P P PS+ G P PP P P+
Sbjct: 310 ------------PSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 357
Query: 410 IYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRDSPDPTPQVS 469
A + +A P P S + A Q NA A SP P+P V
Sbjct: 358 PPALALPPLQAPPSPPASPP-LSPLATPSPQAP----NALAVHLLQA--PFSPPPSPPVQ 410
Query: 470 ATITVMAAHPEEDHRTIYLSSPDS--AVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESH 527
A + A+ P T +P S A +Q P P + + + T Q +
Sbjct: 411 APFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA-SPPMSPSATPPPQAPPPLAAP 469
Query: 528 AHSASESKPKERPAI--PPKLSKSSPVGS-------------PVSPSAGGPPVSPLADLS 572
++ P+ PA+ PP + SP S P+SP A PP +P
Sbjct: 470 PLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV--- 526
Query: 573 DGSSGGSSIGPQPPS-------QGPADPAPSCRTNGVAIS---DPSRCPQPAASSASEQR 622
++ + P PP+ + P P P +G ++ P P P+ S +S
Sbjct: 527 -LAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLS 585
Query: 623 RP 624
P
Sbjct: 586 GP 587
Score = 44.3 bits (103), Expect = 8e-04
Identities = 92/415 (22%), Positives = 139/415 (33%), Gaps = 71/415 (17%)
Query: 261 PGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQEKRGPSF------------- 307
P PV AA + G+ G G + + G + P + GP+
Sbjct: 35 PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERA 94
Query: 308 -PKECCSQGP---------TAHPSCLGPKKLSLTSEAAIS---------SDGLSCG---- 344
P + S GP T P LG K L +++E ++ LS G
Sbjct: 95 PPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRD 154
Query: 345 -SGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLG-----LTGEPQPP 398
SG G SP + + + P P P P P + + T EP P
Sbjct: 155 TSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPA 214
Query: 399 AHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWG 458
A R + + +++ ++ P S A+ +A+G + + K
Sbjct: 215 AR-RRPSAGGGLQRPASRSLSSSATPLSSPAR--SGPSARGTPR-APAHPSQPKPKGLQA 270
Query: 459 RDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAG 518
P TP + T S+P S P P S + T
Sbjct: 271 LRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPS------PSAPPSLQTLPSPPATPPS 324
Query: 519 QGLSSRES----HAHSASESKPKERPAIPPKLSKSS----PVGSPVSPSAGGPPVSPLAD 570
Q +S S HS S P A PP + + P+ +P SP A PP+SPLA
Sbjct: 325 QATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPA-SPPLSPLAT 383
Query: 571 LSDGSSGGSSI---------GPQPPSQGPADPAPSCRTNGVAISDPSRCPQPAAS 616
S + ++ P PP Q P P P+ + + PS+ P A+
Sbjct: 384 PSPQAPNALAVHLLQAPFSPPPSPPVQAPFSP-PASPPVSPSATPPSQAPPSLAA 437
Score = 42.7 bits (99), Expect = 0.002
Identities = 102/485 (21%), Positives = 160/485 (32%), Gaps = 78/485 (16%)
Query: 379 GCPGVTPS-RCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAA 437
G TP+ R GL P+PP PR P P+ + + ++ AA A
Sbjct: 11 GAAARTPAARAPGLL-TPRPPGSPRP---PPPV--------------TPAALRVLGAAGA 52
Query: 438 QGQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMA--------AHPEEDHRTIYLS 489
G+ + A++A G P+ P+ T T A P ++ +S
Sbjct: 53 VGRKPL------AERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVS 106
Query: 490 SPDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKS 549
SP A G P GP+ Q G +S+ E+ A + PK R A+ +
Sbjct: 107 SPGRASGTTRP-GPLGQK----------GLRISAEETVARGKATEAPK-RSALSAGARRD 154
Query: 550 SPVGSPVSPSAGGPPVSPLADLSDG-SSGGSSIGPQPPSQGPADPAPSCRTNGVAISDPS 608
+ +P +PS S A G S P+PP++GP S + P+
Sbjct: 155 TSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPA 214
Query: 609 RCPQPAASSASEQRRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTT 668
+P+A ++ R + + + ++GP+ + T
Sbjct: 215 ARRRPSAGGGLQRPASRSLSSS------------------ATPLSSPARSGPS--ARGTP 254
Query: 669 WHRLHPTD----GSSGQNSKVGTGMSKSASFAFEFPKDRSGIETFSPPPPPPKSRHLLKM 724
HP+ G T K A+ A P S + T SP PP S
Sbjct: 255 RAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG-PLSSSPLATPSPSAPPSPSAPPSLQ 313
Query: 725 NKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGSTDSLASDSRTCSDGGPSSELAHSPTNS 784
S SQ + SP+ + H + LA+ L P+
Sbjct: 314 TLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPP 373
Query: 785 GKKLFAPVPFPSGSTEDVSP----SGPQQPPPLPQKKIVSRAASSPDGFFWTQGSPKPGT 840
+P+ PS + P PPP P + +SP + + P
Sbjct: 374 ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP---VSPSATPPSQ 430
Query: 841 ASPKL 845
A P L
Sbjct: 431 APPSL 435
Score = 37.7 bits (86), Expect = 0.078
Identities = 28/93 (30%), Positives = 37/93 (39%), Gaps = 4/93 (4%)
Query: 1155 TLQAG----PGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGPREKQLPRLII 1210
TLQA P P +P P APP + P PA+ P SP Q P +
Sbjct: 334 TLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALA 393
Query: 1211 SNFLKAKQKPGGTPNLQQKKSQARLAPEIVSAS 1243
+ L+A P +P +Q S P SA+
Sbjct: 394 VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT 426
Score = 34.7 bits (78), Expect = 0.66
Identities = 37/107 (34%), Positives = 45/107 (42%), Gaps = 18/107 (16%)
Query: 1148 NLLLVHCTLQAGPGPAPAP---APAPAAAAPPCS-SAAPPAGGTLS------------PA 1191
N L VH LQA P P+P AP A+PP S SA PP+ S PA
Sbjct: 390 NALAVHL-LQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA 448
Query: 1192 AGPASPEGPREKQLPRLIISNFLK-AKQKPGGTPNLQQKKSQARLAP 1237
+ P SP Q P + + L+ AK P P L QA +P
Sbjct: 449 SPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSP 495
Score = 34.7 bits (78), Expect = 0.66
Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 6/81 (7%)
Query: 1164 PAPAPAPAAAAPPCSSA-APPAG----GTLSPAAG-PASPEGPREKQLPRLIISNFLKAK 1217
P P PA A PP + +PPA SP+A P SP Q P ++ + L+
Sbjct: 476 PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVP 535
Query: 1218 QKPGGTPNLQQKKSQARLAPE 1238
P +P LQ + P+
Sbjct: 536 PSPPASPTLQAPRRPPTPGPD 556
Score = 30.8 bits (68), Expect = 9.6
Identities = 26/103 (25%), Positives = 37/103 (35%), Gaps = 16/103 (15%)
Query: 1156 LQAGPGPAPAPAPAPAAAAPPCSSAA---------------PPAGGTLSPAAGP-ASPEG 1199
LQA P P +P +P A P + A PP SP A P SP
Sbjct: 366 LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA 425
Query: 1200 PREKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSA 1242
Q P + + L+ P +P + + AP ++A
Sbjct: 426 TPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAA 468
>gi|239508976 PREDICTED: mucin 12, cell surface associated [Homo
sapiens]
Length = 2036
Score = 49.3 bits (116), Expect = 3e-05
Identities = 115/506 (22%), Positives = 177/506 (34%), Gaps = 74/506 (14%)
Query: 458 GRDSPDPTPQVSATITVMAAHPEE----DHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEE 513
G +P P S T + + + T + SSP S P S S V EE
Sbjct: 93 GDSTPSPISSGSMETTALPGSTTKPGLSEKSTTFYSSPRSPDTTHLPASMTS--SGVSEE 150
Query: 514 ETSAGQGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSD 573
T++ S + A S + P LS+ S S S+ GP + L S
Sbjct: 151 STTSHSRPGSTHTTAFPGSTTMPG--------LSQESTA----SHSSPGPTDTTL---SP 195
Query: 574 GSSGGSSIGPQPPS--QGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTW 631
GS+ SS+GP+ + P + + S P SS AG+
Sbjct: 196 GSTTASSLGPEYTTFHSRPGSTETTLLPDNTTASGLLEASMPVHSSTRSPHTTLSPAGST 255
Query: 632 SRQCRIEEEEEVEQELLSHSW--GRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGM 689
+RQ + HSW ++T+ P +TT + P+ S G S + T
Sbjct: 256 TRQ---------GESTTFHSWPSSKDTRPAPP----TTTSAFVEPSTTSHGSPSSIPTTH 302
Query: 690 SKSASFAFEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAE-----SLSP 744
+ S ++ + T+ P ++ H + + +S E+ + + S +P
Sbjct: 303 ISARSTTSGLVEEST---TYHSSPGSTQTMHFPESDTTSGRGEESTTSHSSTTHTISSAP 359
Query: 745 SFRGVHVSFTTGSTDSLAS-------DSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSG 797
S V T S S DS T S S +HS ++ + P +
Sbjct: 360 STTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTS 419
Query: 798 -----STEDVSPSGPQQPPPLPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSET 852
ST SG + LP + F + SP T SP S + +
Sbjct: 420 VLLGESTTSPISSGSMETTALPGSTTTPGLSERSTTFHSSPRSPAT-TLSP---ASTTSS 475
Query: 853 NVHDESHFSYSLSPGNRHHPVF--SSSDPLEKAFKGSGHWLPAAGLAGNRGGCGSPGLQC 910
V +ES S S PG+ H F S++ P + H P G L
Sbjct: 476 GVSEESTTSRS-RPGSTHTTAFPDSTTTPGLSRHSTTSHSSP---------GSTDTTLLP 525
Query: 911 KGAPSASSSQLSVSSQASTGSTQLQL 936
++ SQ S +S +S+GST L
Sbjct: 526 ASTTTSGPSQESTTSHSSSGSTDTAL 551
Score = 43.9 bits (102), Expect = 0.001
Identities = 132/544 (24%), Positives = 191/544 (35%), Gaps = 96/544 (17%)
Query: 459 RDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAG 518
R P T + + E+ T+Y SS S +P + S GEE T+
Sbjct: 763 RSQPGSTHSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFPHSTTT--SVHGEEPTT-- 818
Query: 519 QGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGS--- 575
SR + H+ ++ + + S + P GSP S G P ADL + S
Sbjct: 819 --FHSRPASTHTTLFTEDSTTSGLTEE-STAFP-GSPASTQTGLPATLTTADLGEESTTF 874
Query: 576 -SGGSSIGPQPPSQGPADPAPSCRTNGVAISDPSRCP-----------QPAASSASEQ-- 621
S S G + PA S + V S PSR P S SE+
Sbjct: 875 PSSSGSTGTK------LSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKST 928
Query: 622 ---RRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGS 678
PR T S E+ SHS T S +T+ PT
Sbjct: 929 TFYTSPRSPDATLS-PATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSDLSQEPTTSH 987
Query: 679 SGQNSKVGT---GMSKSASFAFE---------------FPKD--RSG-IETFSPPPPPPK 717
S Q S T G + ++S + P D SG +E +P
Sbjct: 988 SSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTG 1047
Query: 718 SRH--LLKMNKSSSDLEKVSQ-----GSAESLSPSFRG-----VHVSFTTGS------TD 759
S H L + +S+ L++ S S+ +PS G V VS T S T
Sbjct: 1048 SLHTTLTPASSTSAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTT 1107
Query: 760 SLASDSRTCSDGGPSSELAHSPTNSGKKLF-----APVPFPSGSTEDVSPSGPQQPPPLP 814
++ S T S+ + SP +G LF V +T +S SG + LP
Sbjct: 1108 HFSASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPIS-SGSTETTALP 1166
Query: 815 QKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHHPVF 874
+ + F+ + SP T SP S + + V +ES S+S PG+ H F
Sbjct: 1167 GSTTTAGLSEKSTTFYSSPRSPDT-TLSP---ASTTSSGVSEESTTSHS-RPGSTHTTAF 1221
Query: 875 SSSDPLEKAFKGS--GHWLPAAGLAGNRGGCGSPGLQCKGAPSASSSQLSVSSQASTGST 932
S + + S H P G+ SPG ++S S + +S GST
Sbjct: 1222 PGSTTMPGVSQESTASHSSP-----GSTDTTLSPG----STTASSLGPESTTFHSSPGST 1272
Query: 933 QLQL 936
+ L
Sbjct: 1273 ETTL 1276
Score = 38.9 bits (89), Expect = 0.035
Identities = 154/725 (21%), Positives = 251/725 (34%), Gaps = 121/725 (16%)
Query: 201 PSTQESFRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQRCSPSGDSEGGEYCSILDCC 260
PS+ S KL+ TTSG P R S S + + SP+ S E +
Sbjct: 875 PSSSGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLS-EKSTTFYTS 933
Query: 261 PGSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQEKRGPSFPKECC----SQGP 316
P SP A + T S G E+ S +FP SQ P
Sbjct: 934 PRSPDATLSPATTTSSGVS----------EESSTSHSQPGSTHTTAFPDSTTTSDLSQEP 983
Query: 317 TAHPSCLGPKKLSL----TSEAAISSDGLSCGSGSG-------------SG---ASSPFV 356
T S G + +L T+ +++ + S G SG AS+P
Sbjct: 984 TTSHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTH 1043
Query: 357 PHLESDYCSL---------MKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPA---HPREA 404
S + +L ++E + Q P TPS G T P + H R +
Sbjct: 1044 SSTGSLHTTLTPASSTSAGLQEESTTFQSWPSSSDTTPSPP-GTTAAPVEVSTTYHSRPS 1102
Query: 405 TQPEPIYAEST----KRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD 460
+ P ++ S+ + +++ V S A + V G +SG
Sbjct: 1103 STPTTHFSASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSG---- 1158
Query: 461 SPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQG 520
S + T +T T + + T + SSP S P S S V EE T++
Sbjct: 1159 STETTALPGSTTTAGLS----EKSTTFYSSPRSPDTTLSPASTTS--SGVSEESTTS--- 1209
Query: 521 LSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSS 580
SR H+ A P S + P S S ++ P S LS GS+ SS
Sbjct: 1210 -HSRPGSTHTT---------AFPG--STTMPGVSQESTASHSSPGSTDTTLSPGSTTASS 1257
Query: 581 IGPQPPS--QGPADPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCRIE 638
+GP+ + P + + S P SS AG+ +RQ
Sbjct: 1258 LGPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQ---- 1313
Query: 639 EEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAFE 698
+ SW P + ++ + L T S G S T ++S
Sbjct: 1314 -----GESTTFQSWPSSKDTMPAPPTTTSAFVELSTT--SHGSPSSTPTTHFSASSTTLG 1366
Query: 699 FPKDRSGIET----FSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSP-SFRGVHVSF 753
++ + + + + P P +S ++S L V + +A SP S + +H F
Sbjct: 1367 RSEESTTVHSSPVATATTPSPARS--------TTSGL--VEESTAYHSSPGSTQTMH--F 1414
Query: 754 TTGSTDSLASDSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGPQQPPPL 813
ST S S+ S + ++ P+ + + P + S + P+
Sbjct: 1415 PESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSIATTHFPESSTTS 1474
Query: 814 PQKKIVSRAASSPDGFFWTQG-SPKPGTASPKLNLSHSETNVHDESHFSYSLSPGNRHHP 872
+ + + + SSPD T G +P P +H T+ ++ +SPG+
Sbjct: 1475 GRSEESTASHSSPD----TNGITPLP---------AHFTTSGRIAESTTFYISPGSMETT 1521
Query: 873 VFSSS 877
+ S++
Sbjct: 1522 LASTA 1526
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 48.9 bits (115), Expect = 3e-05
Identities = 77/277 (27%), Positives = 109/277 (39%), Gaps = 51/277 (18%)
Query: 381 PGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQ 440
P P L TG+ PP H A A ST +PVP+ AA +G
Sbjct: 1080 PSEEPDLDLAGTGDRTPPPHSHPA-------APST----GSPVPATEPP----AAKEEGV 1124
Query: 441 GQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSPD-------- 492
+ + W +A GR P P+ Q + PEED + +PD
Sbjct: 1125 LGPWSPSPWPSQA----GRSPPPPSEQTPGNPLINFL-PEEDTP---IGAPDLGLPSLSW 1176
Query: 493 ---SAVGVQWPRGPVSQNS-EVGEEETSAGQGLSSRESHAHSASESKPKER--PAIPPKL 546
S G+Q P P SQN VG++ S ++ + +PK R P +PP+
Sbjct: 1177 PRVSTDGLQTPATPESQNDFPVGKDSQSQLPPPWRDRTNEVFKDDEEPKGRGAPHLPPRP 1236
Query: 547 SKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAPS--CRTNGVA- 603
S + P SPV G SP D+++ +GG ++ +P +G P S T GVA
Sbjct: 1237 SSTLPPLSPV----GSTHSSPSPDVAELWTGG-TVAWEPALEGGLGPVDSELWPTVGVAS 1291
Query: 604 ISDPSRCPQP---AASSASEQRRPRFQA---GTWSRQ 634
+ P P P S+ E P F G+W Q
Sbjct: 1292 LLPPPIAPLPEMKVRDSSLEPGTPSFPTPGPGSWDLQ 1328
Score = 33.1 bits (74), Expect = 1.9
Identities = 28/82 (34%), Positives = 35/82 (42%), Gaps = 14/82 (17%)
Query: 1158 AGPG---PAPAPAPAPAAAAPPCSSAAPPAG------GTLSPAAGPA----SPEGPREKQ 1204
AG G P P PA + P + PPA G SP+ P+ SP P E Q
Sbjct: 1089 AGTGDRTPPPHSHPAAPSTGSPVPATEPPAAKEEGVLGPWSPSPWPSQAGRSPPPPSE-Q 1147
Query: 1205 LPRLIISNFLKAKQKPGGTPNL 1226
P + NFL + P G P+L
Sbjct: 1148 TPGNPLINFLPEEDTPIGAPDL 1169
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 48.9 bits (115), Expect = 3e-05
Identities = 98/405 (24%), Positives = 144/405 (35%), Gaps = 76/405 (18%)
Query: 524 RESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPS---AGGPPVSPLADLSDGSSGGSS 580
+ +H+ ++SK R PP S+S + S S A P P S +S ++
Sbjct: 575 KTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNN 634
Query: 581 IGPQPPSQGPADPAPSCRTNGVAISD---PSRCPQPAASSASEQRRPRFQAGTWSRQCRI 637
+ P S +DP+P + + D PSR + SS S+ P WSR
Sbjct: 635 VSPVSRSHSFSDPSPKFAHHHLRSQDPCPPSRSEVLSQSSDSKSEAPDPTQKAWSR---- 690
Query: 638 EEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAF 697
+ +EV + R T P R P GS QNS+ G S S+
Sbjct: 691 SDSDEVPPRVPV----RTTSRSP------VLSRRDSPLQGSGQQNSQAGQRNSTSSI--- 737
Query: 698 EFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGS 757
+ R E P P S S S S S G H +GS
Sbjct: 738 ---EPRLLWERVEKLVPRPGS----------------GSSSGSSNSGSQPGSHPGSQSGS 778
Query: 758 TDSLASDSRTCSDGGPSSEL--AHSPTNSGKKLFAPVPFPSG------------STEDVS 803
+ S + S+G PS L A K++F P+ P+G + EDV
Sbjct: 779 GERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLK-PAGEVDLTALAKELRAVEDVR 837
Query: 804 PSGPQQPPPLPQKKIVSRAASSPDGFFWTQGS------PKPGTASPKLNLSHSETN---- 853
P P + S D +G+ P+ A+ LNLS+ ET
Sbjct: 838 P--PHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKT 895
Query: 854 --VHDESHFSYSLSPGNRHHPVF----SSSDPLEKAFKGSGHWLP 892
VHD+ +++P + S+S L+K K S + P
Sbjct: 896 MIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQK-HKSSSSFTP 939
Score = 39.3 bits (90), Expect = 0.027
Identities = 87/443 (19%), Positives = 147/443 (33%), Gaps = 67/443 (15%)
Query: 354 PFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAE 413
P VP + + E Q P P V S L P + + P P +A
Sbjct: 594 PPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAH 653
Query: 414 STKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATIT 473
R + PS+S+ + ++ ++ + T AW++ DS + P+V T
Sbjct: 654 HHLRSQDPCPPSRSEV-LSQSSDSKSEAPDPTQKAWSRS-------DSDEVPPRVPVRTT 705
Query: 474 VMAAHPEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASE 533
R+ LS DS + +G QNS+ G+ +S S
Sbjct: 706 ---------SRSPVLSRRDSPL-----QGSGQQNSQAGQR---------------NSTSS 736
Query: 534 SKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADP 593
+P+ + ++ K P P S S+ G S+ GS G P SQ +
Sbjct: 737 IEPR---LLWERVEKLVP--RPGSGSSSG-----------SSNSGSQPGSHPGSQSGSGE 780
Query: 594 APSCRTNGVAISDPSRCPQPAASSASEQR---RPRFQAGTWSRQCRIEEEEEVEQELLSH 650
R++ + PS+ + A +++ RP AG +E VE H
Sbjct: 781 RFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPH 840
Query: 651 SWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFAFEFPKDRSGIETF- 709
+ T + + TT + S G +++AS + ++T
Sbjct: 841 ---KVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMI 897
Query: 710 -------SPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGSTDSLA 762
P P K L+ S+ S+ S +P + + S ++
Sbjct: 898 VHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVT 957
Query: 763 SDSRTCSDGGPSSELAHSPTNSG 785
S DG + PT G
Sbjct: 958 SVVGFSCDGMRPEAIRQDPTRKG 980
Score = 30.8 bits (68), Expect = 9.6
Identities = 12/32 (37%), Positives = 21/32 (65%)
Query: 1120 VCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 1151
+ ++ ++ GL HL H +IHRD+ +N+LL
Sbjct: 130 IAYISREILRGLAHLHIHHVIHRDIKGQNVLL 161
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 48.5 bits (114), Expect = 4e-05
Identities = 95/390 (24%), Positives = 129/390 (33%), Gaps = 74/390 (18%)
Query: 290 EQGKCSG---PAEQEKRGPSFPKECCSQGPTAHPSCLG--PKKLSLTSEAAISSDGLSCG 344
EQGK G P Q++ PK+ QGP P PK +S I S G
Sbjct: 199 EQGKPEGIIKPPLQQQPPKPIPKQ---QGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTG 255
Query: 345 SGSGSGASSPFVPH----LESDYCSLMKE--------------PAPEK----QQDPGCPG 382
+P H L+ D + P+P K Q PG P
Sbjct: 256 KPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPP 315
Query: 383 VT-PSRCLGLTGEPQPPAHPREATQP---------EPIYAESTKRKKAAPV-PSKSQAKI 431
P G +PPA P T+P P+ T + A P+ P+K A
Sbjct: 316 AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPA-- 373
Query: 432 EHAAAAQGQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSP 491
+ + + + A AQ G +P P + T P+ + L SP
Sbjct: 374 QQTGSEKPSSEQPGPKALAQPPGVG---KTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSP 430
Query: 492 DSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKER---PAIPPKLSK 548
A G + PV Q AG G +S A +KP + PA PP
Sbjct: 431 AKAPGPT--KTPVQQPGPGKIPAQQAGPGKTS----AQQTGPTKPPSQLPGPAKPPPQQP 484
Query: 549 SSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAPS--------CRTN 600
P P + PP S S P P GPA P+P +
Sbjct: 485 GPAKPPPQQPGSAKPP----------SQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQP 534
Query: 601 GVAISDPSRCPQPAASSASEQRRPRFQAGT 630
G A ++ P PA SA + +P Q G+
Sbjct: 535 GSA-KPSAQQPSPAKPSAQQSTKPVSQTGS 563
Score = 41.6 bits (96), Expect = 0.005
Identities = 85/369 (23%), Positives = 125/369 (33%), Gaps = 47/369 (12%)
Query: 578 GSSIGPQPPSQGPA-DPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCR 636
G + P P S P AP T+ V+ S P QP +S + P+ +
Sbjct: 647 GGDLAPVPSSPQPKLKTAPVTTTSAVSKSSP----QPQQTSPKKDAAPKQDLSKAPEPKK 702
Query: 637 IEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFA 696
V+Q L S + K P S S P+ S + V K
Sbjct: 703 --PPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMV 760
Query: 697 FEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVS-FTT 755
S + P P K++ L+ S ++S P+ G VS F +
Sbjct: 761 KPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPT--GEKVSPFDS 818
Query: 756 GSTDSLASDSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGPQQPPPLPQ 815
+ ASDS+ S GPSSE + G+K PV ++ + P P
Sbjct: 819 KAIPRPASDSKIISHPGPSSE------SKGQKQVDPV-----QKKEEPKKAQTKMSPKPD 867
Query: 816 KKIVSRAASSPDGFFWTQG--------SPKPGTASPKLNLSHSETNVHDESHFSYSLSPG 867
K + + + +P G T G SPKP S + +L+ S++
Sbjct: 868 AKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLG------------SITDA 915
Query: 868 NRHHPVFSSSDPLEKAFK-GSGHWLPAAGLAGNRGGCG-----SPGLQCKGAPSASSSQL 921
+ P K F G+ + A+ L G G PG K AP+ S
Sbjct: 916 PKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPT 975
Query: 922 SVSSQASTG 930
S STG
Sbjct: 976 SQGPPKSTG 984
Score = 34.7 bits (78), Expect = 0.66
Identities = 97/438 (22%), Positives = 142/438 (32%), Gaps = 92/438 (21%)
Query: 30 CKNCFCLRS---DHQLVAGPPQPR------------AGSLPPPPRLPPRPENCRLEDEGV 74
C NC R+ D V PQP+ + S P P + P+ + +D
Sbjct: 637 CLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSK 696
Query: 75 NSSPYSKPTIAVKPTMMSSEASDVWTEANLSAEVSQVIWRRAPGKLPLPKQED-APVVYL 133
P P + +PT+ S ++ +A E + P + +P ++D APV
Sbjct: 697 APEPKKPPPLVKQPTLHGSPSA----KAKQPPEADSLSKPAPPKEPSVPSEQDKAPV--- 749
Query: 134 GSFRGVQKPAGPSTSPDGNSRCPPAYTMVGLHNLEPRGERNIAFHPVSFPEEKAVHKEKP 193
KP P P +V + + + P S + +A K P
Sbjct: 750 ----ADDKPKQP-------KMVKPTTDLVSSSSATTKPD-----IPSSKVQSQAEEKTTP 793
Query: 194 SF------PYQDRPSTQES---FRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQRCSP 244
P Q P T E F K + S PGP ES + +
Sbjct: 794 PLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKE 853
Query: 245 SGDSEGGEYCSILDCCP---GSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQE 301
+ D P GSP TAG PT + K P EQ
Sbjct: 854 EPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAG--------QTVPTPQQSPK---PQEQS 902
Query: 302 KRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLES 361
+R S + P + P+ T + ++ G G GAS + S
Sbjct: 903 RRF-SLNLGSITDAPKSQPT---------TPQETVT------GKLFGFGAS---IFSQAS 943
Query: 362 DYCSLMKEPAPEKQQDPGCP---GVTPSRCLGLTGEPQPPAHPREATQPEPIYAES--TK 416
+ S +P P Q PG P PS+ P P+ Q P A+S K
Sbjct: 944 NLISTAGQPGPHSQSGPGAPMKQAPAPSQ------PPTSQGPPKSTGQAPPAPAKSIPVK 997
Query: 417 RKKAAPVPSKSQAKIEHA 434
++ AP K + K E A
Sbjct: 998 KETKAPAAEKLEPKAEQA 1015
Score = 32.7 bits (73), Expect = 2.5
Identities = 63/247 (25%), Positives = 82/247 (33%), Gaps = 41/247 (16%)
Query: 34 FCLRSDHQLVAGPPQPRAGSLPPPPRLPPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSS 93
F S + A PP P PPPP PP P P P + KPT++
Sbjct: 2393 FFRSSSLDISAQPPPPPPPPPPPPPPPPPPP------------PPPLPPPTSPKPTILPK 2440
Query: 94 E----ASDVWTEANLSAEVSQVIWRRAPGKLPLPKQEDAPVVYLGSFRGVQKPAGPSTSP 149
+ AS V T L V+ + + + PV + + P PS+ P
Sbjct: 2441 KKLTVASPVTTATPLFDAVTTL------ETTAVLRSNGLPVTRICTTAPPPVPPKPSSIP 2494
Query: 150 DGNSRCPPAYTMVGLHNLEPRGERNIAFHPVSFPEEKAVHKEKPSFPYQDRPSTQESFRQ 209
G +V H EP + IA PV K P S S
Sbjct: 2495 SG---------LVFTHRPEP-SKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTL 2544
Query: 210 KLAAFAGTTSGCHQGPGPLRESLPSEDDSDQRCSPSGDSEGGEYCSI-LDCCPGSPVAKA 268
L TS ++ P P P + S R S S Y I L PG+P +
Sbjct: 2545 NL-----VTSADYKLPSPTSPLSPHSNKSSPRFSKSLTE---TYVVITLPSEPGTPTDSS 2596
Query: 269 ASQTAGS 275
ASQ S
Sbjct: 2597 ASQAITS 2603
Score = 31.6 bits (70), Expect = 5.6
Identities = 29/85 (34%), Positives = 35/85 (41%), Gaps = 20/85 (23%)
Query: 1160 PGPAPAPAPAPAAAAPP---CSSAAPPA---GGTLSP--AAGPA--SPEGPREKQLPRLI 1209
PGPA P P A PP SA PP+ G T P GPA SP+ P + P
Sbjct: 474 PGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPP--- 530
Query: 1210 ISNFLKAKQKPGGTPNLQQKKSQAR 1234
Q+PG Q+ S A+
Sbjct: 531 -------SQQPGSAKPSAQQPSPAK 548
Score = 31.2 bits (69), Expect = 7.3
Identities = 29/95 (30%), Positives = 41/95 (43%), Gaps = 22/95 (23%)
Query: 1157 QAGPGP----APAPAPAPAAAAPPCSSA-APPAGG--------TLSPAAGPASPEGPR-- 1201
Q+GPG APAP+ P + PP S+ APPA T +PAA P+ +
Sbjct: 957 QSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP 1016
Query: 1202 -------EKQLPRLIISNFLKAKQKPGGTPNLQQK 1229
EK+ P + S L A+ + P +K
Sbjct: 1017 TVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEK 1051
Score = 30.8 bits (68), Expect = 9.6
Identities = 31/100 (31%), Positives = 41/100 (41%), Gaps = 15/100 (15%)
Query: 1157 QAGPGPAPAPAPAPAAAAP--PCSSAAPP--AGGTLSPAAGPASPEGPREKQLPRLIISN 1212
Q GP P+ P PA P P + PP G P+ P S + P ++ P
Sbjct: 463 QTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPA----- 517
Query: 1213 FLKAKQKPGGT-PNLQQ----KKSQARLAPEIVSASQYRK 1247
+ Q+PG T P QQ K S + +P SA Q K
Sbjct: 518 -KPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTK 556
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 48.5 bits (114), Expect = 4e-05
Identities = 95/390 (24%), Positives = 129/390 (33%), Gaps = 74/390 (18%)
Query: 290 EQGKCSG---PAEQEKRGPSFPKECCSQGPTAHPSCLG--PKKLSLTSEAAISSDGLSCG 344
EQGK G P Q++ PK+ QGP P PK +S I S G
Sbjct: 199 EQGKPEGIIKPPLQQQPPKPIPKQ---QGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTG 255
Query: 345 SGSGSGASSPFVPH----LESDYCSLMKE--------------PAPEK----QQDPGCPG 382
+P H L+ D + P+P K Q PG P
Sbjct: 256 KPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPP 315
Query: 383 VT-PSRCLGLTGEPQPPAHPREATQP---------EPIYAESTKRKKAAPV-PSKSQAKI 431
P G +PPA P T+P P+ T + A P+ P+K A
Sbjct: 316 AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPA-- 373
Query: 432 EHAAAAQGQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSP 491
+ + + + A AQ G +P P + T P+ + L SP
Sbjct: 374 QQTGSEKPSSEQPGPKALAQPPGVG---KTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSP 430
Query: 492 DSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKER---PAIPPKLSK 548
A G + PV Q AG G +S A +KP + PA PP
Sbjct: 431 AKAPGPT--KTPVQQPGPGKIPAQQAGPGKTS----AQQTGPTKPPSQLPGPAKPPPQQP 484
Query: 549 SSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGPADPAPS--------CRTN 600
P P + PP S S P P GPA P+P +
Sbjct: 485 GPAKPPPQQPGSAKPP----------SQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQP 534
Query: 601 GVAISDPSRCPQPAASSASEQRRPRFQAGT 630
G A ++ P PA SA + +P Q G+
Sbjct: 535 GSA-KPSAQQPSPAKPSAQQSTKPVSQTGS 563
Score = 41.6 bits (96), Expect = 0.005
Identities = 85/369 (23%), Positives = 125/369 (33%), Gaps = 47/369 (12%)
Query: 578 GSSIGPQPPSQGPA-DPAPSCRTNGVAISDPSRCPQPAASSASEQRRPRFQAGTWSRQCR 636
G + P P S P AP T+ V+ S P QP +S + P+ +
Sbjct: 647 GGDLAPVPSSPQPKLKTAPVTTTSAVSKSSP----QPQQTSPKKDAAPKQDLSKAPEPKK 702
Query: 637 IEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFA 696
V+Q L S + K P S S P+ S + V K
Sbjct: 703 --PPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMV 760
Query: 697 FEFPKDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVS-FTT 755
S + P P K++ L+ S ++S P+ G VS F +
Sbjct: 761 KPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPT--GEKVSPFDS 818
Query: 756 GSTDSLASDSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVSPSGPQQPPPLPQ 815
+ ASDS+ S GPSSE + G+K PV ++ + P P
Sbjct: 819 KAIPRPASDSKIISHPGPSSE------SKGQKQVDPV-----QKKEEPKKAQTKMSPKPD 867
Query: 816 KKIVSRAASSPDGFFWTQG--------SPKPGTASPKLNLSHSETNVHDESHFSYSLSPG 867
K + + + +P G T G SPKP S + +L+ S++
Sbjct: 868 AKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLG------------SITDA 915
Query: 868 NRHHPVFSSSDPLEKAFK-GSGHWLPAAGLAGNRGGCG-----SPGLQCKGAPSASSSQL 921
+ P K F G+ + A+ L G G PG K AP+ S
Sbjct: 916 PKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPT 975
Query: 922 SVSSQASTG 930
S STG
Sbjct: 976 SQGPPKSTG 984
Score = 34.7 bits (78), Expect = 0.66
Identities = 97/438 (22%), Positives = 142/438 (32%), Gaps = 92/438 (21%)
Query: 30 CKNCFCLRS---DHQLVAGPPQPR------------AGSLPPPPRLPPRPENCRLEDEGV 74
C NC R+ D V PQP+ + S P P + P+ + +D
Sbjct: 637 CLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSK 696
Query: 75 NSSPYSKPTIAVKPTMMSSEASDVWTEANLSAEVSQVIWRRAPGKLPLPKQED-APVVYL 133
P P + +PT+ S ++ +A E + P + +P ++D APV
Sbjct: 697 APEPKKPPPLVKQPTLHGSPSA----KAKQPPEADSLSKPAPPKEPSVPSEQDKAPV--- 749
Query: 134 GSFRGVQKPAGPSTSPDGNSRCPPAYTMVGLHNLEPRGERNIAFHPVSFPEEKAVHKEKP 193
KP P P +V + + + P S + +A K P
Sbjct: 750 ----ADDKPKQP-------KMVKPTTDLVSSSSATTKPD-----IPSSKVQSQAEEKTTP 793
Query: 194 SF------PYQDRPSTQES---FRQKLAAFAGTTSGCHQGPGPLRESLPSEDDSDQRCSP 244
P Q P T E F K + S PGP ES + +
Sbjct: 794 PLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKE 853
Query: 245 SGDSEGGEYCSILDCCP---GSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQE 301
+ D P GSP TAG PT + K P EQ
Sbjct: 854 EPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAG--------QTVPTPQQSPK---PQEQS 902
Query: 302 KRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLES 361
+R S + P + P+ T + ++ G G GAS + S
Sbjct: 903 RRF-SLNLGSITDAPKSQPT---------TPQETVT------GKLFGFGAS---IFSQAS 943
Query: 362 DYCSLMKEPAPEKQQDPGCP---GVTPSRCLGLTGEPQPPAHPREATQPEPIYAES--TK 416
+ S +P P Q PG P PS+ P P+ Q P A+S K
Sbjct: 944 NLISTAGQPGPHSQSGPGAPMKQAPAPSQ------PPTSQGPPKSTGQAPPAPAKSIPVK 997
Query: 417 RKKAAPVPSKSQAKIEHA 434
++ AP K + K E A
Sbjct: 998 KETKAPAAEKLEPKAEQA 1015
Score = 32.7 bits (73), Expect = 2.5
Identities = 63/247 (25%), Positives = 82/247 (33%), Gaps = 41/247 (16%)
Query: 34 FCLRSDHQLVAGPPQPRAGSLPPPPRLPPRPENCRLEDEGVNSSPYSKPTIAVKPTMMSS 93
F S + A PP P PPPP PP P P P + KPT++
Sbjct: 2393 FFRSSSLDISAQPPPPPPPPPPPPPPPPPPP------------PPPLPPPTSPKPTILPK 2440
Query: 94 E----ASDVWTEANLSAEVSQVIWRRAPGKLPLPKQEDAPVVYLGSFRGVQKPAGPSTSP 149
+ AS V T L V+ + + + PV + + P PS+ P
Sbjct: 2441 KKLTVASPVTTATPLFDAVTTL------ETTAVLRSNGLPVTRICTTAPPPVPPKPSSIP 2494
Query: 150 DGNSRCPPAYTMVGLHNLEPRGERNIAFHPVSFPEEKAVHKEKPSFPYQDRPSTQESFRQ 209
G +V H EP + IA PV K P S S
Sbjct: 2495 SG---------LVFTHRPEP-SKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTL 2544
Query: 210 KLAAFAGTTSGCHQGPGPLRESLPSEDDSDQRCSPSGDSEGGEYCSI-LDCCPGSPVAKA 268
L TS ++ P P P + S R S S Y I L PG+P +
Sbjct: 2545 NL-----VTSADYKLPSPTSPLSPHSNKSSPRFSKSLTE---TYVVITLPSEPGTPTDSS 2596
Query: 269 ASQTAGS 275
ASQ S
Sbjct: 2597 ASQAITS 2603
Score = 31.6 bits (70), Expect = 5.6
Identities = 29/85 (34%), Positives = 35/85 (41%), Gaps = 20/85 (23%)
Query: 1160 PGPAPAPAPAPAAAAPP---CSSAAPPA---GGTLSP--AAGPA--SPEGPREKQLPRLI 1209
PGPA P P A PP SA PP+ G T P GPA SP+ P + P
Sbjct: 474 PGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPP--- 530
Query: 1210 ISNFLKAKQKPGGTPNLQQKKSQAR 1234
Q+PG Q+ S A+
Sbjct: 531 -------SQQPGSAKPSAQQPSPAK 548
Score = 31.2 bits (69), Expect = 7.3
Identities = 29/95 (30%), Positives = 41/95 (43%), Gaps = 22/95 (23%)
Query: 1157 QAGPGP----APAPAPAPAAAAPPCSSA-APPAGG--------TLSPAAGPASPEGPR-- 1201
Q+GPG APAP+ P + PP S+ APPA T +PAA P+ +
Sbjct: 957 QSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP 1016
Query: 1202 -------EKQLPRLIISNFLKAKQKPGGTPNLQQK 1229
EK+ P + S L A+ + P +K
Sbjct: 1017 TVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEK 1051
Score = 30.8 bits (68), Expect = 9.6
Identities = 31/100 (31%), Positives = 41/100 (41%), Gaps = 15/100 (15%)
Query: 1157 QAGPGPAPAPAPAPAAAAP--PCSSAAPP--AGGTLSPAAGPASPEGPREKQLPRLIISN 1212
Q GP P+ P PA P P + PP G P+ P S + P ++ P
Sbjct: 463 QTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPA----- 517
Query: 1213 FLKAKQKPGGT-PNLQQ----KKSQARLAPEIVSASQYRK 1247
+ Q+PG T P QQ K S + +P SA Q K
Sbjct: 518 -KPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTK 556
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 48.5 bits (114), Expect = 4e-05
Identities = 124/561 (22%), Positives = 191/561 (34%), Gaps = 117/561 (20%)
Query: 369 EPAPEK---QQDPGCPGVTPSRCLGLTGEPQPPAHPREATQPEPIYAESTKRKKAAPVPS 425
EP PE ++ PG+ + L+ P A +PE + + P P
Sbjct: 1891 EPKPEALLARRSLQPPGIESEKSEKLSSFPS--LQKDGAKEPERKEQPLQRHPSSIPPPP 1948
Query: 426 KSQAKIEHAAAAQ--GQGQVCTGNAWAQKAASGWGRDSPDPTPQVSATITVMAAH---PE 480
+ + AA Q +G K ++ SP P+ A + ++H P
Sbjct: 1949 LTAKDLSSPAARQHCSSPSHASGREPGAKPSTAEPSSSPQDPPKPVAAHSESSSHKPRPG 2008
Query: 481 EDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKERP 540
D PD ++ Q P S + G+E + G SSRE H S+S P P
Sbjct: 2009 PDPGPPKTKHPDRSLSSQKP----SVGATKGKEPATQSLGGSSREGKGH--SKSGPDVFP 2062
Query: 541 AIPPKLSKSSPVGSPVSPSAGGPPV------SPLADLSDGSSGGSSIG--------PQPP 586
A P +K+S + GGP V +PL +SGG + P+P
Sbjct: 2063 ATPGSQNKAS---DGIGQGEGGPSVPLHTDRAPLDAKPQPTSGGRPLEVLEKPVHLPRPG 2119
Query: 587 SQGPADPA--------------PSCRTNGVAISDPSRCPQ---------PAASSASEQRR 623
GP++PA P P+ C Q P+ +A+ RR
Sbjct: 2120 HPGPSEPADQKLSAVGEKQTLSPKHPKPSTVKDCPTLCKQTDNRQTDKSPSQPAANTDRR 2179
Query: 624 PRFQAGTWSRQCRIEEEEEVEQELLSHSWGR-----------------ETKNGPTDHSNS 666
+ T + E ++ HS R GP
Sbjct: 2180 AEGKKCTEALYAPAEGDKLEAGLSFVHSENRLKGAERPAAGVGKGFPEARGKGPGPQKPP 2239
Query: 667 TTWHR---LHPTDGSSGQNSKVGTGM-SKSASFAFEFPKDRSGIETFSPPPPPPKSRHLL 722
T + + + ++GQ+S T + KS S + FP+ R+G+ S
Sbjct: 2240 TEADKPNGMKRSPSATGQSSFRSTALPEKSLSCSSSFPETRAGVREASAA---------- 2289
Query: 723 KMNKSSSDLEKVSQGSAESLSPSFRGVHVSFTTGSTDSLASDSRTCSDGGPSSELAHSPT 782
S + K + G E +PS R + G T SD PS ++ P
Sbjct: 2290 ---SSDTSSAKAAGGMLELPAPSNRDHRKAQPAGE----GRTHMTKSDSLPSFRVSTLPL 2342
Query: 783 N------------SGKKLFAPVPFPSGSTEDVSPSGPQQPPPLPQKKIVSRAASSPDGFF 830
S + V G T+ P+ P QPPP +K+ V R + P
Sbjct: 2343 ESHHPDPNTMGGASHRDRALSVTATVGETKGKDPA-PAQPPP-ARKQNVGRDVTKP---- 2396
Query: 831 WTQGSPKPGTASPKLNLSHSE 851
SP P T P ++LS+ +
Sbjct: 2397 ----SPAPNTDRP-ISLSNEK 2412
>gi|7657387 CCR4-NOT transcription complex, subunit 3 [Homo sapiens]
Length = 753
Score = 48.5 bits (114), Expect = 4e-05
Identities = 88/410 (21%), Positives = 143/410 (34%), Gaps = 61/410 (14%)
Query: 460 DSPDPTPQVSATITVMAAHPEEDHRTIYLSSPDSAVGVQ-WPRGPVSQNSEVGEEETSAG 518
D D + AT +H E++ S+P S P P + +E E++ G
Sbjct: 230 DLEDIPQALVATSPPSHSHMEDEIFNQSSSTPTSTTSSSPIPPSPANCTTENSEDDKKRG 289
Query: 519 QGLSSRESHAHSASESKPKERPAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGG 578
+ S S + + + SKP P SP P PS G PP + + G++G
Sbjct: 290 RSTDSEVSQSPAKNGSKPVHSNQHP-----QSPAVPPTYPS-GPPPAASALSTTPGNNGV 343
Query: 579 SSIGPQPPSQGP-ADPAPSCRTNGVA-ISDPSRCPQPAASSASEQRRPRFQAGTWSRQCR 636
+ P + GP A PAPS + A + P P+ S ++ R P Q
Sbjct: 344 PAPAAPPSALGPKASPAPSHNSGTPAPYAQAVAPPAPSGPSTTQPRPPSVQPS------- 396
Query: 637 IEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHPTDGSSGQNSKVGTGMSKSASFA 696
G G + SNS+ +G++ +S V ++ A
Sbjct: 397 ------------GGGGGGSGGGGSSSSSNSSAGGGAGKQNGATSYSSVVADSPAEVA--L 442
Query: 697 FEFPKDRSGIETFSPPP----PPPKSRHLLKMNKSSSDLEKVSQGSAESLSPSFRGVHVS 752
+ + + PP PPP + +K S G S + G
Sbjct: 443 SSSGGNNASSQALGPPSGPHNPPPST------SKEPSAAAPTGAGGVAPGSGNNSGGPSL 496
Query: 753 FTTGSTDSLASDSRTCSDGGPSSELAHSPTNSGKKLFAPVPFPSGSTEDVS-----PSGP 807
+ +S + + SD + L + P P P S + ++ SG
Sbjct: 497 LVPLPVNPPSSPTPSFSDAKAAGALLNGPPQFSTAPEIKAPEPLSSLKSMAERAAISSGI 556
Query: 808 QQPPP---LPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNV 854
+ P P L ++ I+ + S+P P +A P L L SE N+
Sbjct: 557 EDPVPTLHLTERDIILSSTSAP-----------PASAQPPLQL--SEVNI 593
Score = 33.9 bits (76), Expect = 1.1
Identities = 55/217 (25%), Positives = 78/217 (35%), Gaps = 38/217 (17%)
Query: 225 PGPLRESL----PSEDDSDQRCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAGSRGRHG 280
P P +++ PS + Q PS GG GS ++S + S G
Sbjct: 368 PAPYAQAVAPPAPSGPSTTQPRPPSVQPSGGGG-------GGSGGGGSSSSSNSSAGGGA 420
Query: 281 GRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQ--GPTAHPSCLGPKKLSLTSEAA-IS 337
G+ T + PAE S SQ GP + P P S AA
Sbjct: 421 GKQNGATSYSSVVADSPAEVALSS-SGGNNASSQALGPPSGPHNPPPSTSKEPSAAAPTG 479
Query: 338 SDGLSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLG--LTGEP 395
+ G++ GSG+ SG S V P P P + ++ G L G P
Sbjct: 480 AGGVAPGSGNNSGGPSLLV-------------PLPVNPPSSPTPSFSDAKAAGALLNGPP 526
Query: 396 QPPAHPREATQPEPIYAESTKRKKAA-------PVPS 425
Q P E PEP+ + + ++AA PVP+
Sbjct: 527 QFSTAP-EIKAPEPLSSLKSMAERAAISSGIEDPVPT 562
Score = 33.5 bits (75), Expect = 1.5
Identities = 19/49 (38%), Positives = 22/49 (44%), Gaps = 3/49 (6%)
Query: 1159 GPGPAPAPAPAPAAAAPPCSSAAPPAGGTLSP---AAGPASPEGPREKQ 1204
G PAPA P+A P S A GT +P A P +P GP Q
Sbjct: 339 GNNGVPAPAAPPSALGPKASPAPSHNSGTPAPYAQAVAPPAPSGPSTTQ 387
>gi|150378545 POM121 membrane glycoprotein (rat)-like [Homo sapiens]
Length = 987
Score = 48.1 bits (113), Expect = 6e-05
Identities = 152/696 (21%), Positives = 232/696 (33%), Gaps = 130/696 (18%)
Query: 225 PGPLRESLPSEDDSD----QRCSPSGDSEGGEYCSILDCCPGSPVAKAASQTAG--SRGR 278
PG L+ L S+ D + S S S G Y S + + + + S T G +
Sbjct: 104 PGSLKRGLNSQSSDDHLNKRSRSSSMSSLTGAYTSGIPSSSRNAITSSYSSTRGISQLWK 163
Query: 279 HGGRDCSPTCWEQGKCSGPAEQEKRGPSFPKECCSQGPTAHPSCLGPKKLSLTSEAAISS 338
G SP S PA + P P + + H S +S +++
Sbjct: 164 RNGPSSSPF-------SSPASSRSQTPERPAKKIREEELCHHS---------SSSTPLAA 207
Query: 339 DGLSCGSGSGSGASSPFVPHLESDYCSLMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPP 398
D S G + ++P K+ Q PG G + L P
Sbjct: 208 DKES--QGEKAADTTP------------RKKQNSNSQSTPGSSGQRKRKVQLL-----PS 248
Query: 399 AHPREATQPEP------IYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQK 452
+ T P P I AE +K A + +QA + +
Sbjct: 249 RRGEQLTLPPPPQLGYSITAEDLDLEKKASLQWFNQALEDKS-----------------D 291
Query: 453 AASGWGRDSPDPTPQVSATITVMAAHPEEDHRTIYLSSP----DSAVGVQWPRGPVSQNS 508
AAS ++P PT Q S T T+ AA ++ S +S +Q P
Sbjct: 292 AASNSVTETP-PTTQPSFTFTLPAAATASPPTSLLAPSTNPLLESLKKMQTPPSLPPCPE 350
Query: 509 EVGEEETSAGQGLSSRESHAHSASESKPKERPAIPPK-LSKSSPVGSPVSPSAGGPPVSP 567
G T A S PK +PP LS+S P G SPS P +
Sbjct: 351 SAGAATTEA---------------LSPPKTPSLLPPLGLSQSGPPGLLPSPSFDSKPPTT 395
Query: 568 LADLSDGSSGGSSIGPQPPS----------QGPADPAPSCRTN---GVAISDPSRCPQPA 614
L L S + + P Q + P+P+ + + G + PS PA
Sbjct: 396 LLGLIPAPSMVPATDTKAPPTLQAETATKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPA 455
Query: 615 ASSASEQRRPRFQAGTWSRQCRIEEEEEVEQELLSHSWGRETKNGPTDHSNSTTWHRLHP 674
ASSAS +P F A S E+E + T P+ S TT P
Sbjct: 456 ASSASPMFKPIFTAPPKS-----------EKEGPTPPGPSVTATAPSSSSLPTTTSTTAP 504
Query: 675 TDGSSGQNSKVGTGMSKSASFAFEFP-KDRSGIETFSPPPPPPKSRHLLKMNKSSSDLEK 733
T V + M AS P ++ +P P L + + +
Sbjct: 505 T------FQPVFSSMGPPASVPLPAPFFKQTTTPATAPTTTAPLFTGLASATSAVAPITS 558
Query: 734 VSQGSAESLSPSFRGVHVSFTTGSTDSLASDSRTCSD-----GGPSSELAHSPTNSGKKL 788
S + + P+F G ++ + S+ S + + T + G P + A G
Sbjct: 559 ASPSTDSASKPAF-GFGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIF 617
Query: 789 FAPVPFPSGSTEDVSPSGPQQPPPLPQKKIVSRAASSPDGFFWTQGSPKPGTAS-PKLNL 847
P +T V+ P +P S +A+ GF T + P T+S P L
Sbjct: 618 QFGKPPALPTTTTVTTFSQSLPTAVP--TATSSSAADFSGFGSTLATSAPATSSQPTLTF 675
Query: 848 SHSETNVHDESHFSYSLS-----PGNRHHPVFSSSD 878
S++ T + S + S PG P F +++
Sbjct: 676 SNTSTPTFNIPFGSSAKSPLPSYPGANPQPAFGAAE 711
>gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]
Length = 1796
Score = 47.8 bits (112), Expect = 8e-05
Identities = 99/377 (26%), Positives = 132/377 (35%), Gaps = 67/377 (17%)
Query: 258 DCCPGSPVAKAASQT----AGSRGRHGGRDCSPTCWEQGKCSGPAEQEKRGPSFPK-ECC 312
+ CP P + + S+T G G GG +QG+ GP +GP P+ E
Sbjct: 1442 ESCPDLPHSCSCSETNEVALGPAGPPGGPGLRGPKGQQGE-PGP-----KGPDGPRGEIG 1495
Query: 313 SQGPTAHPSCLGPKKLSLTSEAAISSD-------GLSCGSGSGSGASSPFVPHLESDYCS 365
GP P GP LS+ + + GL G G SP S
Sbjct: 1496 LPGPQGPPGPQGPSGLSIQGMPGMPGEKGEKGDTGLPGPQGIPGGVGSP------GRDGS 1549
Query: 366 LMKEPAPEKQQDPGCPGVTPSRCLGLTGEPQPPA-----HPREATQPEPIYAESTKRKKA 420
+ P K G PG P +G+ G P P P+ A P + +R +
Sbjct: 1550 PGQRGLPGKDGSSGPPG--PPGPIGIPGTPGVPGITGSMGPQGALGPPGVPGAKGERGER 1607
Query: 421 APVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRDSP--DPTPQVSATITVMAAH 478
+ +SQA + A QVC Q S R + + P S++I +
Sbjct: 1608 GDL--QSQAMVRSVAR-----QVCE-----QLIQSHMARYTAILNQIPSHSSSIRTVQGP 1655
Query: 479 PEEDHRTIYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAGQGLSSRESHAHSASESKPKE 538
P E R SP A G Q P G G T +GL+ + +
Sbjct: 1656 PGEPGRP---GSP-GAPGEQGPPGTPGFPGNAGVPGTPGERGLTGIKGEKGNPGVGTQGP 1711
Query: 539 R----PAIPPKLSKSSPVGSPVSPSAGGPPVSPLADLSDGSSGGSSIGPQPPSQGP--AD 592
R PA P S+ G P SP GPP G G GPQ PS P D
Sbjct: 1712 RGPPGPAGPSGESRPGSPGPPGSPGPRGPP---------GHLGVP--GPQGPSGQPGYCD 1760
Query: 593 PAPSCRTNGVAISDPSR 609
P+ SC GV P +
Sbjct: 1761 PS-SCSAYGVRAPHPDQ 1776
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,246,139
Number of Sequences: 37866
Number of extensions: 4743520
Number of successful extensions: 45967
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 449
Number of HSP's successfully gapped in prelim test: 1159
Number of HSP's that attempted gapping in prelim test: 29312
Number of HSP's gapped (non-prelim): 16042
length of query: 1402
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1287
effective length of database: 13,892,928
effective search space: 17880198336
effective search space used: 17880198336
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.