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Search of human proteins with 157694487
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157694487 CMT1A duplicated region transcript 1 [Homo
sapiens]
(752 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 1541 0.0
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 1363 0.0
gi|239756740 PREDICTED: similar to CMT1A duplicated region trans... 758 0.0
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 122 1e-27
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 122 1e-27
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 122 1e-27
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 98 2e-20
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 98 2e-20
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 98 2e-20
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 95 3e-19
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 95 3e-19
gi|16554629 WD repeat domain 5 [Homo sapiens] 91 3e-18
gi|16554627 WD repeat domain 5 [Homo sapiens] 91 3e-18
gi|23199987 WD repeat domain 5B [Homo sapiens] 91 4e-18
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 90 9e-18
gi|157266266 WD repeat domain 86 [Homo sapiens] 86 1e-16
gi|21071067 TBP-associated factor 5 [Homo sapiens] 81 3e-15
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 79 1e-14
gi|19913369 transducin beta-like 3 [Homo sapiens] 77 6e-14
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 77 8e-14
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 75 2e-13
gi|18874090 WD repeat domain 48 [Homo sapiens] 74 5e-13
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 74 6e-13
gi|32189425 WD repeat domain 69 [Homo sapiens] 73 1e-12
gi|113865883 WD repeat domain 38 [Homo sapiens] 72 2e-12
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] 70 7e-12
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 70 7e-12
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 69 2e-11
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 68 3e-11
gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens] 68 4e-11
>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
Length = 752
Score = 1541 bits (3991), Expect = 0.0
Identities = 752/752 (100%), Positives = 752/752 (100%)
Query: 1 MENLESRLKNAPYFRCEKGTDSIPLCRKCETRVLAWKIFSTKEWFCRINDISQRRFLVGI 60
MENLESRLKNAPYFRCEKGTDSIPLCRKCETRVLAWKIFSTKEWFCRINDISQRRFLVGI
Sbjct: 1 MENLESRLKNAPYFRCEKGTDSIPLCRKCETRVLAWKIFSTKEWFCRINDISQRRFLVGI 60
Query: 61 LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRIDLSKKEGKVVKSSLNQMLDKTVEQKMKE 120
LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRIDLSKKEGKVVKSSLNQMLDKTVEQKMKE
Sbjct: 61 LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRIDLSKKEGKVVKSSLNQMLDKTVEQKMKE 120
Query: 121 ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS 180
ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS
Sbjct: 121 ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS 180
Query: 181 PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHFLGAASNPEEPWRNSLRCISEMNRL 240
PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHFLGAASNPEEPWRNSLRCISEMNRL
Sbjct: 181 PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHFLGAASNPEEPWRNSLRCISEMNRL 240
Query: 241 FSGKADITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK 300
FSGKADITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK
Sbjct: 241 FSGKADITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK 300
Query: 301 CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK 360
CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK
Sbjct: 301 CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK 360
Query: 361 SMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLMEERNVFCGTYNVRILSDTWDQNRVIHY 420
SMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLMEERNVFCGTYNVRILSDTWDQNRVIHY
Sbjct: 361 SMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLMEERNVFCGTYNVRILSDTWDQNRVIHY 420
Query: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW
Sbjct: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
Query: 481 DLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILAT 540
DLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILAT
Sbjct: 481 DLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILAT 540
Query: 541 RINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWS 600
RINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWS
Sbjct: 541 RINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWS 600
Query: 601 MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPV 660
MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPV
Sbjct: 601 MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPV 660
Query: 661 LSFFIQGNRISVCHISTFAKRINVGWNGIEPSATAQGGNASLTECAHVRLHIAGHLPASR 720
LSFFIQGNRISVCHISTFAKRINVGWNGIEPSATAQGGNASLTECAHVRLHIAGHLPASR
Sbjct: 661 LSFFIQGNRISVCHISTFAKRINVGWNGIEPSATAQGGNASLTECAHVRLHIAGHLPASR 720
Query: 721 LPVAAVQPMTGGMAPTTAPTHVLAMLILFSGV 752
LPVAAVQPMTGGMAPTTAPTHVLAMLILFSGV
Sbjct: 721 LPVAAVQPMTGGMAPTTAPTHVLAMLILFSGV 752
>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
Length = 1051
Score = 1363 bits (3528), Expect = 0.0
Identities = 663/672 (98%), Positives = 667/672 (99%)
Query: 1 MENLESRLKNAPYFRCEKGTDSIPLCRKCETRVLAWKIFSTKEWFCRINDISQRRFLVGI 60
MENLESRLKNAPYFRCEKGTDSIPLCRKCET VLAWKIFSTKEWFCRINDISQRRFLVGI
Sbjct: 1 MENLESRLKNAPYFRCEKGTDSIPLCRKCETCVLAWKIFSTKEWFCRINDISQRRFLVGI 60
Query: 61 LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRIDLSKKEGKVVKSSLNQMLDKTVEQKMKE 120
LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRI+LSKKEGKVVKSSLNQMLDKTVEQKMKE
Sbjct: 61 LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGKVVKSSLNQMLDKTVEQKMKE 120
Query: 121 ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS 180
ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS
Sbjct: 121 ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS 180
Query: 181 PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHFLGAASNPEEPWRNSLRCISEMNRL 240
PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEH LGAASNPEEPWRNSLRCISEMNRL
Sbjct: 181 PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHLLGAASNPEEPWRNSLRCISEMNRL 240
Query: 241 FSGKADITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK 300
FSGK DITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK
Sbjct: 241 FSGKGDITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK 300
Query: 301 CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK 360
CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK
Sbjct: 301 CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK 360
Query: 361 SMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLMEERNVFCGTYNVRILSDTWDQNRVIHY 420
SMRVKHPKWKLRTKNEYNLWTAYQNEETQQVL+EERNVFCGTYNVRILSDTWDQNRVIHY
Sbjct: 361 SMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLIEERNVFCGTYNVRILSDTWDQNRVIHY 420
Query: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW
Sbjct: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
Query: 481 DLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILAT 540
DLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILAT
Sbjct: 481 DLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILAT 540
Query: 541 RINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWS 600
RINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWS
Sbjct: 541 RINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWS 600
Query: 601 MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPV 660
MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNF NGNCMKV+KANGRGDPV
Sbjct: 601 MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGRGDPV 660
Query: 661 LSFFIQGNRISV 672
LSFFIQGNR+ V
Sbjct: 661 LSFFIQGNRMVV 672
>gi|239756740 PREDICTED: similar to CMT1A duplicated region
transcript 1 [Homo sapiens]
Length = 433
Score = 758 bits (1958), Expect = 0.0
Identities = 371/374 (99%), Positives = 372/374 (99%)
Query: 1 MENLESRLKNAPYFRCEKGTDSIPLCRKCETRVLAWKIFSTKEWFCRINDISQRRFLVGI 60
MENLESRLKNAPYFRCEKGTDS PLCRKCET VLAWKIFSTKEWFCRINDISQRRFLVGI
Sbjct: 3 MENLESRLKNAPYFRCEKGTDSNPLCRKCETCVLAWKIFSTKEWFCRINDISQRRFLVGI 62
Query: 61 LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRIDLSKKEGKVVKSSLNQMLDKTVEQKMKE 120
LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRI+LSKKEGKVVKSSLNQMLDKTVEQKMKE
Sbjct: 63 LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGKVVKSSLNQMLDKTVEQKMKE 122
Query: 121 ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS 180
ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS
Sbjct: 123 ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS 182
Query: 181 PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHFLGAASNPEEPWRNSLRCISEMNRL 240
PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHFLGAASNPEEPWRNSLRCISEMNRL
Sbjct: 183 PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHFLGAASNPEEPWRNSLRCISEMNRL 242
Query: 241 FSGKADITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK 300
FSGKADITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK
Sbjct: 243 FSGKADITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK 302
Query: 301 CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK 360
CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK
Sbjct: 303 CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK 362
Query: 361 SMRVKHPKWKLRTK 374
SMRVKHPKWKLRTK
Sbjct: 363 SMRVKHPKWKLRTK 376
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 122 bits (306), Expect = 1e-27
Identities = 90/381 (23%), Positives = 170/381 (44%), Gaps = 43/381 (11%)
Query: 275 RDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQG 334
RDFI LP L+ Y+L L+ L + A ++W +A+ + + + +
Sbjct: 160 RDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAE-------------DNLLWREK 206
Query: 335 SYTRGID-PNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLM 393
GID P + + + P + H WK ++ + T ++ E +
Sbjct: 207 CKEEGIDEPLHIKRRKVIKPGFI---------HSPWKSAYIRQHRIDTNWRRGE-----L 252
Query: 394 EERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHA 453
+ V G ++ +++ + + G +++ S + + + + K + GH
Sbjct: 253 KSPKVLKG-HDDHVIT-------CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRT-LVGHT 303
Query: 454 GSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGR 513
G V + + +N ++SGS D +++ W+ ++G C GH T+ CM L + R+VSG R
Sbjct: 304 GGVWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSR 361
Query: 514 DCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSG 572
D ++VWD++TG+CL H + + + +VS +VKVW + TL G
Sbjct: 362 DATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG 421
Query: 573 HEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDVSLLFLRVISA 631
H V L FD H++SGS D + W + + C+ H + L ++S
Sbjct: 422 HTNRVYSLQFDGIHVVSGSLDTSIRVWDV--ETGNCIHTLTGHQSLTSGMELKDNILVSG 479
Query: 632 CADGKIRIYNFFNGNCMKVIK 652
AD ++I++ G C++ ++
Sbjct: 480 NADSTVKIWDIKTGQCLQTLQ 500
Score = 91.3 bits (225), Expect = 3e-18
Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 416 RVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDL 475
R + Y G +++ + + + + D + + +GH V +L + ++SGS D
Sbjct: 387 RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 443
Query: 476 SIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF---- 531
SIR WD+++G C GHQ + M+L N LVSG D VK+WD+ TG+CL+T
Sbjct: 444 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 503
Query: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTL----SGHEGAVKCLFFDQWHL 587
+H+ + + N ++++S + G VK+W + + ++ L SG G V W +
Sbjct: 504 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV------VWRI 557
Query: 588 LSGSTDGLVMAWSMVGKYERCLM 610
+ +T + S G E L+
Sbjct: 558 RASNTKLVCAVGSRNGTEETKLL 580
Score = 90.1 bits (222), Expect = 7e-18
Identities = 55/184 (29%), Positives = 91/184 (49%), Gaps = 8/184 (4%)
Query: 474 DLSIRYWDLKSGVCTRIFGGHQG-TITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF- 531
D + R +LKS ++ GH ITC+ C NR+VSG D +KVW TGKCL+T
Sbjct: 244 DTNWRRGELKS---PKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLV 300
Query: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGS 591
H + ++++ D I+S +KVW+ + + TL GH V+C+ + ++SGS
Sbjct: 301 GHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGS 360
Query: 592 TDGLVMAWSM-VGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKV 650
D + W + G+ LM H V V RV+S D +++++ C+
Sbjct: 361 RDATLRVWDIETGQCLHVLMG--HVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHT 418
Query: 651 IKAN 654
++ +
Sbjct: 419 LQGH 422
Score = 62.0 bits (149), Expect = 2e-09
Identities = 42/157 (26%), Positives = 74/157 (47%), Gaps = 23/157 (14%)
Query: 391 VLMEERNVFCGTYNVRILSDTWDQ-------------NRV--IHYSGGDLIAVSSNRKIH 435
V + R V G Y+ + WD NRV + + G +++ S + I
Sbjct: 389 VQYDGRRVVSGAYDFMV--KVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIR 446
Query: 436 LLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGG-- 493
+ D+ I GH + L ++N L+SG+ D +++ WD+K+G C + G
Sbjct: 447 VWDVETGNCIHT-LTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 503
Query: 494 -HQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529
HQ +TC+ KN +++ D VK+WD+ TG+ ++
Sbjct: 504 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 540
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 122 bits (306), Expect = 1e-27
Identities = 90/381 (23%), Positives = 170/381 (44%), Gaps = 43/381 (11%)
Query: 275 RDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQG 334
RDFI LP L+ Y+L L+ L + A ++W +A+ + + + +
Sbjct: 278 RDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAE-------------DNLLWREK 324
Query: 335 SYTRGID-PNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLM 393
GID P + + + P + H WK ++ + T ++ E +
Sbjct: 325 CKEEGIDEPLHIKRRKVIKPGFI---------HSPWKSAYIRQHRIDTNWRRGE-----L 370
Query: 394 EERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHA 453
+ V G ++ +++ + + G +++ S + + + + K + GH
Sbjct: 371 KSPKVLKG-HDDHVIT-------CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRT-LVGHT 421
Query: 454 GSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGR 513
G V + + +N ++SGS D +++ W+ ++G C GH T+ CM L + R+VSG R
Sbjct: 422 GGVWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSR 479
Query: 514 DCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSG 572
D ++VWD++TG+CL H + + + +VS +VKVW + TL G
Sbjct: 480 DATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG 539
Query: 573 HEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDVSLLFLRVISA 631
H V L FD H++SGS D + W + + C+ H + L ++S
Sbjct: 540 HTNRVYSLQFDGIHVVSGSLDTSIRVWDV--ETGNCIHTLTGHQSLTSGMELKDNILVSG 597
Query: 632 CADGKIRIYNFFNGNCMKVIK 652
AD ++I++ G C++ ++
Sbjct: 598 NADSTVKIWDIKTGQCLQTLQ 618
Score = 91.3 bits (225), Expect = 3e-18
Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 416 RVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDL 475
R + Y G +++ + + + + D + + +GH V +L + ++SGS D
Sbjct: 505 RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 561
Query: 476 SIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF---- 531
SIR WD+++G C GHQ + M+L N LVSG D VK+WD+ TG+CL+T
Sbjct: 562 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
Query: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTL----SGHEGAVKCLFFDQWHL 587
+H+ + + N ++++S + G VK+W + + ++ L SG G V W +
Sbjct: 622 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV------VWRI 675
Query: 588 LSGSTDGLVMAWSMVGKYERCLM 610
+ +T + S G E L+
Sbjct: 676 RASNTKLVCAVGSRNGTEETKLL 698
Score = 90.1 bits (222), Expect = 7e-18
Identities = 55/184 (29%), Positives = 91/184 (49%), Gaps = 8/184 (4%)
Query: 474 DLSIRYWDLKSGVCTRIFGGHQG-TITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF- 531
D + R +LKS ++ GH ITC+ C NR+VSG D +KVW TGKCL+T
Sbjct: 362 DTNWRRGELKS---PKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLV 418
Query: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGS 591
H + ++++ D I+S +KVW+ + + TL GH V+C+ + ++SGS
Sbjct: 419 GHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGS 478
Query: 592 TDGLVMAWSM-VGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKV 650
D + W + G+ LM H V V RV+S D +++++ C+
Sbjct: 479 RDATLRVWDIETGQCLHVLMG--HVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHT 536
Query: 651 IKAN 654
++ +
Sbjct: 537 LQGH 540
Score = 62.0 bits (149), Expect = 2e-09
Identities = 42/157 (26%), Positives = 74/157 (47%), Gaps = 23/157 (14%)
Query: 391 VLMEERNVFCGTYNVRILSDTWDQ-------------NRV--IHYSGGDLIAVSSNRKIH 435
V + R V G Y+ + WD NRV + + G +++ S + I
Sbjct: 507 VQYDGRRVVSGAYDFMV--KVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIR 564
Query: 436 LLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGG-- 493
+ D+ I GH + L ++N L+SG+ D +++ WD+K+G C + G
Sbjct: 565 VWDVETGNCIHT-LTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
Query: 494 -HQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529
HQ +TC+ KN +++ D VK+WD+ TG+ ++
Sbjct: 622 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 658
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 122 bits (306), Expect = 1e-27
Identities = 90/381 (23%), Positives = 170/381 (44%), Gaps = 43/381 (11%)
Query: 275 RDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQG 334
RDFI LP L+ Y+L L+ L + A ++W +A+ + + + +
Sbjct: 198 RDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAE-------------DNLLWREK 244
Query: 335 SYTRGID-PNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLM 393
GID P + + + P + H WK ++ + T ++ E +
Sbjct: 245 CKEEGIDEPLHIKRRKVIKPGFI---------HSPWKSAYIRQHRIDTNWRRGE-----L 290
Query: 394 EERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHA 453
+ V G ++ +++ + + G +++ S + + + + K + GH
Sbjct: 291 KSPKVLKG-HDDHVIT-------CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRT-LVGHT 341
Query: 454 GSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGR 513
G V + + +N ++SGS D +++ W+ ++G C GH T+ CM L + R+VSG R
Sbjct: 342 GGVWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSR 399
Query: 514 DCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSG 572
D ++VWD++TG+CL H + + + +VS +VKVW + TL G
Sbjct: 400 DATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG 459
Query: 573 HEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDVSLLFLRVISA 631
H V L FD H++SGS D + W + + C+ H + L ++S
Sbjct: 460 HTNRVYSLQFDGIHVVSGSLDTSIRVWDV--ETGNCIHTLTGHQSLTSGMELKDNILVSG 517
Query: 632 CADGKIRIYNFFNGNCMKVIK 652
AD ++I++ G C++ ++
Sbjct: 518 NADSTVKIWDIKTGQCLQTLQ 538
Score = 91.3 bits (225), Expect = 3e-18
Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 416 RVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDL 475
R + Y G +++ + + + + D + + +GH V +L + ++SGS D
Sbjct: 425 RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 481
Query: 476 SIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF---- 531
SIR WD+++G C GHQ + M+L N LVSG D VK+WD+ TG+CL+T
Sbjct: 482 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 541
Query: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTL----SGHEGAVKCLFFDQWHL 587
+H+ + + N ++++S + G VK+W + + ++ L SG G V W +
Sbjct: 542 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV------VWRI 595
Query: 588 LSGSTDGLVMAWSMVGKYERCLM 610
+ +T + S G E L+
Sbjct: 596 RASNTKLVCAVGSRNGTEETKLL 618
Score = 90.1 bits (222), Expect = 7e-18
Identities = 55/184 (29%), Positives = 91/184 (49%), Gaps = 8/184 (4%)
Query: 474 DLSIRYWDLKSGVCTRIFGGHQG-TITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF- 531
D + R +LKS ++ GH ITC+ C NR+VSG D +KVW TGKCL+T
Sbjct: 282 DTNWRRGELKS---PKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLV 338
Query: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGS 591
H + ++++ D I+S +KVW+ + + TL GH V+C+ + ++SGS
Sbjct: 339 GHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGS 398
Query: 592 TDGLVMAWSM-VGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKV 650
D + W + G+ LM H V V RV+S D +++++ C+
Sbjct: 399 RDATLRVWDIETGQCLHVLMG--HVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHT 456
Query: 651 IKAN 654
++ +
Sbjct: 457 LQGH 460
Score = 62.0 bits (149), Expect = 2e-09
Identities = 42/157 (26%), Positives = 74/157 (47%), Gaps = 23/157 (14%)
Query: 391 VLMEERNVFCGTYNVRILSDTWDQ-------------NRV--IHYSGGDLIAVSSNRKIH 435
V + R V G Y+ + WD NRV + + G +++ S + I
Sbjct: 427 VQYDGRRVVSGAYDFMV--KVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIR 484
Query: 436 LLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGG-- 493
+ D+ I GH + L ++N L+SG+ D +++ WD+K+G C + G
Sbjct: 485 VWDVETGNCIHT-LTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 541
Query: 494 -HQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529
HQ +TC+ KN +++ D VK+WD+ TG+ ++
Sbjct: 542 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 578
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 98.2 bits (243), Expect = 2e-20
Identities = 57/196 (29%), Positives = 103/196 (52%), Gaps = 7/196 (3%)
Query: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523
++ ++SG D SI+ WD S C ++ GH G++ C+ + +V+G D V+VWDV+
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 308
Query: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAMA---QLVKTLSGHEGAVKC 579
TG+ L T H + +L R ++ +V+ + + VW +A A L + L GH AV
Sbjct: 309 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 368
Query: 580 LFFDQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638
+ FD +++S S D + WS ++ R L H + + + V+S +D IR
Sbjct: 369 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 426
Query: 639 IYNFFNGNCMKVIKAN 654
+++ G C++V++ +
Sbjct: 427 LWDIECGACLRVLEGH 442
Score = 95.1 bits (235), Expect = 2e-19
Identities = 64/261 (24%), Positives = 125/261 (47%), Gaps = 13/261 (4%)
Query: 389 QQVLMEERNVFCGTYNVRILSDTWDQNRVIH---YSGGDLIAVSSNRKIHLLDIIQVKAI 445
Q + E N CG +N++ + + ++ ++ Y +I+ + I + D ++ +
Sbjct: 214 QDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECL 273
Query: 446 PVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK 505
V GH GSV L L +E +++GS D ++R WD+ +G H + +
Sbjct: 274 KV-LTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 330
Query: 506 NRLVSGGRDCQVKVWDVDTGKCLKTFR----HKDPILATRINDTYIVSSCERGLVKVWHI 561
+V+ +D + VWD+ + + R H+ + +D YIVS+ +KVW
Sbjct: 331 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 390
Query: 562 AMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLD 620
+ + V+TL+GH+ + CL + ++SGS+D + W + + CL + H + V
Sbjct: 391 STCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI--ECGACLRVLEGHEELVRC 448
Query: 621 VSLLFLRVISACADGKIRIYN 641
+ R++S DGKI++++
Sbjct: 449 IRFDNKRIVSGAYDGKIKVWD 469
Score = 67.0 bits (162), Expect = 6e-11
Identities = 45/186 (24%), Positives = 78/186 (41%), Gaps = 33/186 (17%)
Query: 417 VIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLS 476
V+ + +++ S +R I + + + GH + L + ++SGS D +
Sbjct: 368 VVDFDDKYIVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQY--RDRLVVSGSSDNT 424
Query: 477 IRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDP 536
IR WD++ G C R+ GH+ + C+ R+VSG D ++KVWD+ DP
Sbjct: 425 IRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAA--------LDP 476
Query: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596
A ++TL H G V L FD++ ++S S D +
Sbjct: 477 RAP----------------------ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTI 514
Query: 597 MAWSMV 602
+ W +
Sbjct: 515 LIWDFL 520
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 98.2 bits (243), Expect = 2e-20
Identities = 57/196 (29%), Positives = 103/196 (52%), Gaps = 7/196 (3%)
Query: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523
++ ++SG D SI+ WD S C ++ GH G++ C+ + +V+G D V+VWDV+
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 274
Query: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAMA---QLVKTLSGHEGAVKC 579
TG+ L T H + +L R ++ +V+ + + VW +A A L + L GH AV
Sbjct: 275 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 334
Query: 580 LFFDQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638
+ FD +++S S D + WS ++ R L H + + + V+S +D IR
Sbjct: 335 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 392
Query: 639 IYNFFNGNCMKVIKAN 654
+++ G C++V++ +
Sbjct: 393 LWDIECGACLRVLEGH 408
Score = 95.1 bits (235), Expect = 2e-19
Identities = 64/261 (24%), Positives = 125/261 (47%), Gaps = 13/261 (4%)
Query: 389 QQVLMEERNVFCGTYNVRILSDTWDQNRVIH---YSGGDLIAVSSNRKIHLLDIIQVKAI 445
Q + E N CG +N++ + + ++ ++ Y +I+ + I + D ++ +
Sbjct: 180 QDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECL 239
Query: 446 PVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK 505
V GH GSV L L +E +++GS D ++R WD+ +G H + +
Sbjct: 240 KV-LTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 296
Query: 506 NRLVSGGRDCQVKVWDVDTGKCLKTFR----HKDPILATRINDTYIVSSCERGLVKVWHI 561
+V+ +D + VWD+ + + R H+ + +D YIVS+ +KVW
Sbjct: 297 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 356
Query: 562 AMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLD 620
+ + V+TL+GH+ + CL + ++SGS+D + W + + CL + H + V
Sbjct: 357 STCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI--ECGACLRVLEGHEELVRC 414
Query: 621 VSLLFLRVISACADGKIRIYN 641
+ R++S DGKI++++
Sbjct: 415 IRFDNKRIVSGAYDGKIKVWD 435
Score = 67.0 bits (162), Expect = 6e-11
Identities = 45/186 (24%), Positives = 78/186 (41%), Gaps = 33/186 (17%)
Query: 417 VIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLS 476
V+ + +++ S +R I + + + GH + L + ++SGS D +
Sbjct: 334 VVDFDDKYIVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQY--RDRLVVSGSSDNT 390
Query: 477 IRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDP 536
IR WD++ G C R+ GH+ + C+ R+VSG D ++KVWD+ DP
Sbjct: 391 IRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAA--------LDP 442
Query: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596
A ++TL H G V L FD++ ++S S D +
Sbjct: 443 RAP----------------------ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTI 480
Query: 597 MAWSMV 602
+ W +
Sbjct: 481 LIWDFL 486
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 98.2 bits (243), Expect = 2e-20
Identities = 57/196 (29%), Positives = 103/196 (52%), Gaps = 7/196 (3%)
Query: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523
++ ++SG D SI+ WD S C ++ GH G++ C+ + +V+G D V+VWDV+
Sbjct: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 295
Query: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAMA---QLVKTLSGHEGAVKC 579
TG+ L T H + +L R ++ +V+ + + VW +A A L + L GH AV
Sbjct: 296 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 355
Query: 580 LFFDQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638
+ FD +++S S D + WS ++ R L H + + + V+S +D IR
Sbjct: 356 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 413
Query: 639 IYNFFNGNCMKVIKAN 654
+++ G C++V++ +
Sbjct: 414 LWDIECGACLRVLEGH 429
Score = 95.1 bits (235), Expect = 2e-19
Identities = 64/261 (24%), Positives = 125/261 (47%), Gaps = 13/261 (4%)
Query: 389 QQVLMEERNVFCGTYNVRILSDTWDQNRVIH---YSGGDLIAVSSNRKIHLLDIIQVKAI 445
Q + E N CG +N++ + + ++ ++ Y +I+ + I + D ++ +
Sbjct: 201 QDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECL 260
Query: 446 PVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK 505
V GH GSV L L +E +++GS D ++R WD+ +G H + +
Sbjct: 261 KV-LTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 317
Query: 506 NRLVSGGRDCQVKVWDVDTGKCLKTFR----HKDPILATRINDTYIVSSCERGLVKVWHI 561
+V+ +D + VWD+ + + R H+ + +D YIVS+ +KVW
Sbjct: 318 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 377
Query: 562 AMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLD 620
+ + V+TL+GH+ + CL + ++SGS+D + W + + CL + H + V
Sbjct: 378 STCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI--ECGACLRVLEGHEELVRC 435
Query: 621 VSLLFLRVISACADGKIRIYN 641
+ R++S DGKI++++
Sbjct: 436 IRFDNKRIVSGAYDGKIKVWD 456
Score = 67.0 bits (162), Expect = 6e-11
Identities = 45/186 (24%), Positives = 78/186 (41%), Gaps = 33/186 (17%)
Query: 417 VIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLS 476
V+ + +++ S +R I + + + GH + L + ++SGS D +
Sbjct: 355 VVDFDDKYIVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQY--RDRLVVSGSSDNT 411
Query: 477 IRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDP 536
IR WD++ G C R+ GH+ + C+ R+VSG D ++KVWD+ DP
Sbjct: 412 IRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAA--------LDP 463
Query: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596
A ++TL H G V L FD++ ++S S D +
Sbjct: 464 RAP----------------------ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTI 501
Query: 597 MAWSMV 602
+ W +
Sbjct: 502 LIWDFL 507
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 94.7 bits (234), Expect = 3e-19
Identities = 55/196 (28%), Positives = 102/196 (52%), Gaps = 7/196 (3%)
Query: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523
++ ++SG D +I+ WD + C RI GH G++ C+ + +++G D V+VWDV+
Sbjct: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVN 335
Query: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAM---AQLVKTLSGHEGAVKC 579
TG+ L T H + +L R N+ +V+ + + VW +A L + L GH AV
Sbjct: 336 TGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 395
Query: 580 LFFDQWHLLSGSTDGLVMAW-SMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638
+ FD +++S S D + W + ++ R L H + + + V+S +D IR
Sbjct: 396 VDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 453
Query: 639 IYNFFNGNCMKVIKAN 654
+++ G C++V++ +
Sbjct: 454 LWDIECGACLRVLEGH 469
Score = 89.4 bits (220), Expect = 1e-17
Identities = 97/424 (22%), Positives = 167/424 (39%), Gaps = 71/424 (16%)
Query: 275 RDFIRYLPI----HLSKYILRMLDRHTLNKCASVSQHWAAMA-----------QQVKMDL 319
RDFI LP H+++ IL LD +L V + W + + V+ D
Sbjct: 142 RDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDS 201
Query: 320 SAHGFIQN----QITFLQGSYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKN 375
G + Q F PN + P K++ D +++ W+
Sbjct: 202 LWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYP--KIIQDIETIE---SNWRC---G 253
Query: 376 EYNLWTAYQNEETQQVLMEERNVFCGTYN----VRILSDT----WDQNRV---------- 417
++L + ET + V+C Y+ V L D WD+N +
Sbjct: 254 RHSLQRIHCRSETS------KGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHT 307
Query: 418 -----IHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGS 472
+ Y +I SS+ + + D+ + + H +V L L +++ S
Sbjct: 308 GSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIH-HCEAV--LHLRFNNGMMVTCS 364
Query: 473 YDLSIRYWDLKSGV---CTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529
D SI WD+ S R+ GH+ + +D +VS D +KVW+ T + ++
Sbjct: 365 KDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVR 424
Query: 530 TFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLL 588
T HK I + D +VS +++W I ++ L GHE V+C+ FD ++
Sbjct: 425 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV 484
Query: 589 SGSTDGLVMAWSMVGKYE-------RCLMAF-KHPKEVLDVSLLFLRVISACADGKIRIY 640
SG+ DG + W +V + CL +H V + +++S+ D I I+
Sbjct: 485 SGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIW 544
Query: 641 NFFN 644
+F N
Sbjct: 545 DFLN 548
Score = 64.3 bits (155), Expect = 4e-10
Identities = 40/171 (23%), Positives = 80/171 (46%), Gaps = 7/171 (4%)
Query: 498 ITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLV 556
+ C+ ++VSG RD +K+WD +T +C + H +L + ++ I++ V
Sbjct: 270 VYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTV 329
Query: 557 KVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYE----RCLMAF 612
+VW + +++ TL H AV L F+ +++ S D + W M + R L+
Sbjct: 330 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGH 389
Query: 613 KHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPVLSF 663
+ V+D + ++SA D I+++N ++ + + RG L +
Sbjct: 390 RAAVNVVDFDDKY--IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQY 438
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 94.7 bits (234), Expect = 3e-19
Identities = 55/196 (28%), Positives = 102/196 (52%), Gaps = 7/196 (3%)
Query: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523
++ ++SG D +I+ WD + C RI GH G++ C+ + +++G D V+VWDV+
Sbjct: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVN 371
Query: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAM---AQLVKTLSGHEGAVKC 579
TG+ L T H + +L R N+ +V+ + + VW +A L + L GH AV
Sbjct: 372 TGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 431
Query: 580 LFFDQWHLLSGSTDGLVMAW-SMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638
+ FD +++S S D + W + ++ R L H + + + V+S +D IR
Sbjct: 432 VDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 489
Query: 639 IYNFFNGNCMKVIKAN 654
+++ G C++V++ +
Sbjct: 490 LWDIECGACLRVLEGH 505
Score = 89.4 bits (220), Expect = 1e-17
Identities = 97/424 (22%), Positives = 167/424 (39%), Gaps = 71/424 (16%)
Query: 275 RDFIRYLPI----HLSKYILRMLDRHTLNKCASVSQHWAAMA-----------QQVKMDL 319
RDFI LP H+++ IL LD +L V + W + + V+ D
Sbjct: 178 RDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDS 237
Query: 320 SAHGFIQN----QITFLQGSYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKN 375
G + Q F PN + P K++ D +++ W+
Sbjct: 238 LWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYP--KIIQDIETIE---SNWRC---G 289
Query: 376 EYNLWTAYQNEETQQVLMEERNVFCGTYN----VRILSDT----WDQNRV---------- 417
++L + ET + V+C Y+ V L D WD+N +
Sbjct: 290 RHSLQRIHCRSETS------KGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHT 343
Query: 418 -----IHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGS 472
+ Y +I SS+ + + D+ + + H +V L L +++ S
Sbjct: 344 GSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIH-HCEAV--LHLRFNNGMMVTCS 400
Query: 473 YDLSIRYWDLKSGV---CTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529
D SI WD+ S R+ GH+ + +D +VS D +KVW+ T + ++
Sbjct: 401 KDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVR 460
Query: 530 TFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLL 588
T HK I + D +VS +++W I ++ L GHE V+C+ FD ++
Sbjct: 461 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV 520
Query: 589 SGSTDGLVMAWSMVGKYE-------RCLMAF-KHPKEVLDVSLLFLRVISACADGKIRIY 640
SG+ DG + W +V + CL +H V + +++S+ D I I+
Sbjct: 521 SGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIW 580
Query: 641 NFFN 644
+F N
Sbjct: 581 DFLN 584
Score = 64.3 bits (155), Expect = 4e-10
Identities = 40/171 (23%), Positives = 80/171 (46%), Gaps = 7/171 (4%)
Query: 498 ITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLV 556
+ C+ ++VSG RD +K+WD +T +C + H +L + ++ I++ V
Sbjct: 306 VYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTV 365
Query: 557 KVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYE----RCLMAF 612
+VW + +++ TL H AV L F+ +++ S D + W M + R L+
Sbjct: 366 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGH 425
Query: 613 KHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPVLSF 663
+ V+D + ++SA D I+++N ++ + + RG L +
Sbjct: 426 RAAVNVVDFDDKY--IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQY 474
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 91.3 bits (225), Expect = 3e-18
Identities = 52/192 (27%), Positives = 99/192 (51%), Gaps = 14/192 (7%)
Query: 425 LIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKS 484
L++ S ++ + + D+ K + +GH+ V + N ++SGS+D S+R WD+K+
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKT-LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 485 GVCTRIFGGHQGTITCMDLCK--NRLVSGGRDCQVKVWDVDTGKCLKTFRHKD--PILAT 540
G C + H ++ + + + +VS D ++WD +G+CLKT D P+
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 541 RI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFD------QWHLLSGST 592
+ N YI+++ +K+W + + +KT +GH+ C+F + +W ++SGS
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW-IVSGSE 279
Query: 593 DGLVMAWSMVGK 604
D LV W++ K
Sbjct: 280 DNLVYIWNLQTK 291
Score = 90.1 bits (222), Expect = 7e-18
Identities = 66/224 (29%), Positives = 104/224 (46%), Gaps = 14/224 (6%)
Query: 451 GHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDL--CKNRL 508
GH + + + N L+S S D +++ WD+ SG C + GH + C + N +
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144
Query: 509 VSGGRDCQVKVWDVDTGKCLKTF-RHKDPILATRIN--DTYIVSSCERGLVKVWHIAMAQ 565
VSG D V++WDV TGKCLKT H DP+ A N + IVSS GL ++W A Q
Sbjct: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Query: 566 LVKTLSGHEG-AVKCLFF--DQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDV 621
+KTL + V + F + ++L+ + D + W GK + K+ K +
Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFA 264
Query: 622 SLLFLR---VISACADGKIRIYNFFNGNCMKVIKANGRGDPVLS 662
+ ++S D + I+N ++ K G D V+S
Sbjct: 265 NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ--KLQGHTDVVIS 306
Score = 79.3 bits (194), Expect = 1e-14
Identities = 58/217 (26%), Positives = 93/217 (42%), Gaps = 13/217 (5%)
Query: 444 AIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTIT--CM 501
A+ GH +V ++ +L S S D I+ W G + GH+ I+
Sbjct: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95
Query: 502 DLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRIN--DTYIVSSCERGLVKV 558
N LVS D +K+WDV +GKCLKT + H + + N IVS V++
Sbjct: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 559 WHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKYERCLMAF---- 612
W + + +KTL H V + F D ++S S DGL W +CL
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS--GQCLKTLIDDD 213
Query: 613 KHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMK 649
P + S +++A D ++++++ G C+K
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK 250
Score = 43.1 bits (100), Expect = 0.001
Identities = 41/173 (23%), Positives = 67/173 (38%), Gaps = 46/173 (26%)
Query: 493 GHQGTITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPI--LATRINDTYI 547
GH ++ + N L S D +K+W GK KT HK I +A + +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 548 VSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYER 607
VS+ + +K+W ++ + +KTL GH V C F+
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN------------------------ 138
Query: 608 CLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPV 660
P+ L ++S D +RI++ G C+K + A+ DPV
Sbjct: 139 -------PQSNL--------IVSGSFDESVRIWDVKTGKCLKTLPAH--SDPV 174
Score = 39.3 bits (90), Expect = 0.014
Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 5/106 (4%)
Query: 569 TLSGHEGAVKCLFFD---QWHLLSGSTDGLVMAWSMV-GKYERCLMAFKHPKEVLDVSLL 624
TL+GH AV + F +W L S S D L+ W GK+E+ + K + S
Sbjct: 40 TLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 625 FLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPVLSFFIQGNRI 670
++SA D ++I++ +G C+K +K + +F Q N I
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 91.3 bits (225), Expect = 3e-18
Identities = 52/192 (27%), Positives = 99/192 (51%), Gaps = 14/192 (7%)
Query: 425 LIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKS 484
L++ S ++ + + D+ K + +GH+ V + N ++SGS+D S+R WD+K+
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKT-LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 485 GVCTRIFGGHQGTITCMDLCK--NRLVSGGRDCQVKVWDVDTGKCLKTFRHKD--PILAT 540
G C + H ++ + + + +VS D ++WD +G+CLKT D P+
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 541 RI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFD------QWHLLSGST 592
+ N YI+++ +K+W + + +KT +GH+ C+F + +W ++SGS
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW-IVSGSE 279
Query: 593 DGLVMAWSMVGK 604
D LV W++ K
Sbjct: 280 DNLVYIWNLQTK 291
Score = 90.1 bits (222), Expect = 7e-18
Identities = 66/224 (29%), Positives = 104/224 (46%), Gaps = 14/224 (6%)
Query: 451 GHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDL--CKNRL 508
GH + + + N L+S S D +++ WD+ SG C + GH + C + N +
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144
Query: 509 VSGGRDCQVKVWDVDTGKCLKTF-RHKDPILATRIN--DTYIVSSCERGLVKVWHIAMAQ 565
VSG D V++WDV TGKCLKT H DP+ A N + IVSS GL ++W A Q
Sbjct: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Query: 566 LVKTLSGHEG-AVKCLFF--DQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDV 621
+KTL + V + F + ++L+ + D + W GK + K+ K +
Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFA 264
Query: 622 SLLFLR---VISACADGKIRIYNFFNGNCMKVIKANGRGDPVLS 662
+ ++S D + I+N ++ K G D V+S
Sbjct: 265 NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ--KLQGHTDVVIS 306
Score = 79.3 bits (194), Expect = 1e-14
Identities = 58/217 (26%), Positives = 93/217 (42%), Gaps = 13/217 (5%)
Query: 444 AIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTIT--CM 501
A+ GH +V ++ +L S S D I+ W G + GH+ I+
Sbjct: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95
Query: 502 DLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRIN--DTYIVSSCERGLVKV 558
N LVS D +K+WDV +GKCLKT + H + + N IVS V++
Sbjct: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 559 WHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKYERCLMAF---- 612
W + + +KTL H V + F D ++S S DGL W +CL
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS--GQCLKTLIDDD 213
Query: 613 KHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMK 649
P + S +++A D ++++++ G C+K
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK 250
Score = 43.1 bits (100), Expect = 0.001
Identities = 41/173 (23%), Positives = 67/173 (38%), Gaps = 46/173 (26%)
Query: 493 GHQGTITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPI--LATRINDTYI 547
GH ++ + N L S D +K+W GK KT HK I +A + +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 548 VSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYER 607
VS+ + +K+W ++ + +KTL GH V C F+
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN------------------------ 138
Query: 608 CLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPV 660
P+ L ++S D +RI++ G C+K + A+ DPV
Sbjct: 139 -------PQSNL--------IVSGSFDESVRIWDVKTGKCLKTLPAH--SDPV 174
Score = 39.3 bits (90), Expect = 0.014
Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 5/106 (4%)
Query: 569 TLSGHEGAVKCLFFD---QWHLLSGSTDGLVMAWSMV-GKYERCLMAFKHPKEVLDVSLL 624
TL+GH AV + F +W L S S D L+ W GK+E+ + K + S
Sbjct: 40 TLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 625 FLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPVLSFFIQGNRI 670
++SA D ++I++ +G C+K +K + +F Q N I
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 90.9 bits (224), Expect = 4e-18
Identities = 56/214 (26%), Positives = 104/214 (48%), Gaps = 20/214 (9%)
Query: 403 YNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLC 462
+N+ I W + L++ S ++ + L D+ K + +GH+ V
Sbjct: 82 HNLEISDVAWSSD------SSRLVSASDDKTLKLWDVRSGKCLKT-LKGHSNYVFCCNFN 134
Query: 463 EEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDL-CKNRL-VSGGRDCQVKVW 520
N ++SGS+D +++ W++K+G C + H ++ + C L VSG D ++W
Sbjct: 135 PPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Query: 521 DVDTGKCLKTFRHKD--PILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGA 576
D +G+CLKT D P+ + N YI+++ +K+W + + +KT +GH+
Sbjct: 195 DAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNE 254
Query: 577 VKCLFFD------QWHLLSGSTDGLVMAWSMVGK 604
C+F + +W ++SGS D LV W++ K
Sbjct: 255 KYCIFANFSVTGGKW-IVSGSEDNLVYIWNLQTK 287
Score = 85.1 bits (209), Expect = 2e-16
Identities = 65/226 (28%), Positives = 104/226 (46%), Gaps = 18/226 (7%)
Query: 451 GHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDL--CKNRL 508
GH + + + + L+S S D +++ WD++SG C + GH + C + N +
Sbjct: 81 GHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLI 140
Query: 509 VSGGRDCQVKVWDVDTGKCLKTF-RHKDPILATRIN--DTYIVSSCERGLVKVWHIAMAQ 565
+SG D VK+W+V TGKCLKT H DP+ A N + IVS GL ++W A Q
Sbjct: 141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ 200
Query: 566 LVKTLSGHEG-AVKCLFF--DQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDV 621
+KTL + V + F + ++L+ + D + W RCL + H E +
Sbjct: 201 CLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDY--SRGRCLKTYTGHKNEKYCI 258
Query: 622 SLLF-----LRVISACADGKIRIYNFFNGNCMKVIKANGRGDPVLS 662
F ++S D + I+N ++ K G D V+S
Sbjct: 259 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ--KLQGHTDVVIS 302
Score = 37.4 bits (85), Expect = 0.052
Identities = 44/202 (21%), Positives = 74/202 (36%), Gaps = 56/202 (27%)
Query: 487 CTRIFGGHQGTITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKT-FRHKDPI--LATR 541
CT + GH ++ + N L S D + +W GK KT + H I +A
Sbjct: 35 CTLV--GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 542 INDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSM 601
+ + +VS+ + +K+W + + +KTL GH V C F+
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP----------------- 135
Query: 602 VGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPVL 661
P + +IS D ++I+ G C+K + A+ DPV
Sbjct: 136 -------------PSNL---------IISGSFDETVKIWEVKTGKCLKTLSAH--SDPVS 171
Query: 662 --------SFFIQGNRISVCHI 675
S + G+ +C I
Sbjct: 172 AVHFNCSGSLIVSGSYDGLCRI 193
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 89.7 bits (221), Expect = 9e-18
Identities = 71/240 (29%), Positives = 109/240 (45%), Gaps = 42/240 (17%)
Query: 450 RGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKN--R 507
+GH SV+ + L S S D++I+ WD + C R GH ++ + + N
Sbjct: 147 KGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDH 206
Query: 508 LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRIN-DTYIVSSCERG-LVKVWHIAMA 564
+VS RD +K+W+V TG C+KTF H++ + R N D +++SC V+VW +A
Sbjct: 207 IVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATK 266
Query: 565 QLVKTLSGHEGAVKCLFFDQW-------------------------HLLSGSTDGLVMAW 599
+ L HE V+C+ W LLSGS D + W
Sbjct: 267 ECKAELREHEHVVECI---SWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW 323
Query: 600 SMVGKYERCLMAF-KHPKEVLDVSLLFL---RVISACADGK-IRIYNFFNGNCMKVIKAN 654
+ CLM H V V LF + I +CAD K +R++++ N CMK + A+
Sbjct: 324 DV--STGMCLMTLVGHDNWVRGV--LFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAH 379
Score = 63.2 bits (152), Expect = 9e-10
Identities = 49/206 (23%), Positives = 87/206 (42%), Gaps = 28/206 (13%)
Query: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
+G +++ S ++ I + ++ Q F GH VR + ++ + S S D ++R W
Sbjct: 203 NGDHIVSASRDKTIKMWEV-QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
Query: 481 DLKSGVCTRIFGGHQGTITCMDLCKNR----------------------LVSGGRDCQVK 518
+ + C H+ + C+ L+SG RD +K
Sbjct: 262 VVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIK 321
Query: 519 VWDVDTGKCLKTFRHKDPILATRI---NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEG 575
+WDV TG CL T D + + +I+S + ++VW + +KTL+ HE
Sbjct: 322 MWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEH 381
Query: 576 AVKCLFFDQW--HLLSGSTDGLVMAW 599
V L F + ++++GS D V W
Sbjct: 382 FVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 59.3 bits (142), Expect = 1e-08
Identities = 54/251 (21%), Positives = 108/251 (43%), Gaps = 33/251 (13%)
Query: 420 YSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRY 479
+SG L + S++ I L D + I GH +V ++ + + ++S S D +I+
Sbjct: 160 HSGKLLASCSADMTIKLWDFQGFECIRT-MHGHDHNVSSVAIMPNGDHIVSASRDKTIKM 218
Query: 480 WDLKSGVCTRIFGGHQGTITCM--DLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPI 537
W++++G C + F GH+ + + + + S D V+VW V T +C R + +
Sbjct: 219 WEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHV 278
Query: 538 LA----------TRINDT-------------YIVSSCERGLVKVWHIAMAQLVKTLSGHE 574
+ + I++ +++S +K+W ++ + TL GH+
Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD 338
Query: 575 GAVKCLFFDQW--HLLSGSTDGLVMAWSMVGKYERC---LMAFKHPKEVLDVSLLFLRVI 629
V+ + F +LS + D + W K +RC L A +H LD V+
Sbjct: 339 NWVRGVLFHSGGKFILSCADDKTLRVWDY--KNKRCMKTLNAHEHFVTSLDFHKTAPYVV 396
Query: 630 SACADGKIRIY 640
+ D ++++
Sbjct: 397 TGSVDQTVKVW 407
Score = 46.2 bits (108), Expect = 1e-04
Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 3/102 (2%)
Query: 422 GGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 481
G L++ S ++ I + D+ + + GH VR + F+LS + D ++R WD
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCL-MTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWD 366
Query: 482 LKSGVCTRIFGGHQGTITCMDLCKNR--LVSGGRDCQVKVWD 521
K+ C + H+ +T +D K +V+G D VKVW+
Sbjct: 367 YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 43.1 bits (100), Expect = 0.001
Identities = 32/123 (26%), Positives = 54/123 (43%), Gaps = 7/123 (5%)
Query: 533 HKDPILATRINDTY--IVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWH--LL 588
H+ P+ + + +VS+ E +KVW +TL GH +V+ + FD L
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
Query: 589 SGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLL--FLRVISACADGKIRIYNFFNGN 646
S S D + W G +E H V V+++ ++SA D I+++ G
Sbjct: 167 SCSADMTIKLWDFQG-FECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGY 225
Query: 647 CMK 649
C+K
Sbjct: 226 CVK 228
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 86.3 bits (212), Expect = 1e-16
Identities = 46/155 (29%), Positives = 76/155 (49%), Gaps = 1/155 (0%)
Query: 450 RGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLV 509
RGH G+V L L + +GS D +IR WD+ SG R+F H+G++ C++L +
Sbjct: 190 RGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVY 249
Query: 510 SGGRDCQVKVWDVDTGKCLKTF-RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVK 568
SG D VK W DTG+C++TF H+ + A + + + + + + +L +
Sbjct: 250 SGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRR 309
Query: 569 TLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVG 603
GH + C+ L + S DG + W + G
Sbjct: 310 VFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRG 344
Score = 75.1 bits (183), Expect = 2e-13
Identities = 53/219 (24%), Positives = 87/219 (39%), Gaps = 18/219 (8%)
Query: 452 HAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSG 511
H G + L L + LL+GS D + R W G C + GH+ +T L +
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
Query: 512 GRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTL 570
DC ++ WDV TG+CL+ +R H + + + + SS +VW + Q+ +
Sbjct: 74 SADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREF 133
Query: 571 SGHEGAVKCLFFD-QWH---------------LLSGSTDGLVMAWSMV-GKYERCLMAFK 613
GH V L + W L++GSTDG W + G + L
Sbjct: 134 RGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHT 193
Query: 614 HPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIK 652
L + + D IR ++ +G ++V +
Sbjct: 194 GAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFR 232
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 81.3 bits (199), Expect = 3e-15
Identities = 80/319 (25%), Positives = 137/319 (42%), Gaps = 36/319 (11%)
Query: 334 GSYTRGIDPNYANKVSIPVPKMVDDGKS---MRVKHPKWKLRTKNE-------YNLWTAY 383
GS ++ DPN + IP+P++ D K M +K ++R + Y AY
Sbjct: 411 GSKSKKQDPNAPPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAY 470
Query: 384 QNEETQQVLMEERNVFCGTY---NVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDII 440
Q V ++ ++ G + VR+ S T + R + + +++ +L+ I
Sbjct: 471 QGLTAVDVT-DDSSLIAGGFADSTVRVWSVTPKKLRSVKQASD--LSLIDKESDDVLERI 527
Query: 441 QVKAIPVEFR---GHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGT 497
+ E + GH+G V + N+LLS S D ++R W L++ C + GH
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYP 587
Query: 498 I--TCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCE 552
+ T VSGG D ++W D + L+ F H + TR N Y+ +
Sbjct: 588 VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 647
Query: 553 RGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWS-----MVGKY 605
V++W + V+ +GH+G + L F + L +G+TDG V+ W MVG+
Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707
Query: 606 ER-----CLMAFKHPKEVL 619
+ C + F E+L
Sbjct: 708 KGHTDTVCSLRFSRDGEIL 726
Score = 60.1 bits (144), Expect = 7e-09
Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 5/116 (4%)
Query: 449 FRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNR- 507
F GH V N++ +GS D ++R WD+ +G C RIF GH+G I + N
Sbjct: 623 FAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR 682
Query: 508 -LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVW 559
L +G D +V +WD+ G + + H D + + R + + S V++W
Sbjct: 683 FLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 45.1 bits (105), Expect = 2e-04
Identities = 45/202 (22%), Positives = 74/202 (36%), Gaps = 46/202 (22%)
Query: 472 SYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLC--KNRLVSGGRDCQVKVWDVDTGKCLK 529
S D+ R D K+ +I GH G + +N L+S D V++W + T CL
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 579
Query: 530 TFR-HKDPILATRINDT--YIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWH 586
++ H P+ T+ + Y VS + ++W Q ++ +GH V C F
Sbjct: 580 GYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF---- 635
Query: 587 LLSGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGN 646
HP V + AD +R+++ NGN
Sbjct: 636 ---------------------------HPNSNY--------VATGSADRTVRLWDVLNGN 660
Query: 647 CMKVIKANGRGDPVLSFFIQGN 668
C+++ G P+ S N
Sbjct: 661 CVRIF--TGHKGPIHSLTFSPN 680
Score = 30.4 bits (67), Expect = 6.3
Identities = 13/34 (38%), Positives = 19/34 (55%)
Query: 448 EFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 481
E +GH +V +L + L SGS D ++R WD
Sbjct: 706 ELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 79.3 bits (194), Expect = 1e-14
Identities = 64/250 (25%), Positives = 115/250 (46%), Gaps = 17/250 (6%)
Query: 417 VIHYSGGDLIAVSSNR-KIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDL 475
V+ + G L+A + +++L I + I + GH V ++ L E +++GS
Sbjct: 27 VLGKASGRLLATGGDDCRVNLWSINKPNCI-MSLTGHTSPVESVRLNTPEELIVAGSQSG 85
Query: 476 SIRYWDLKSGVCTRIFGGHQGTITCMDL--CKNRLVSGGRDCQVKVWDVDTGKCLKTFR- 532
SIR WDL++ R GH+ I +D + SG +D +K+WD+ C+ +R
Sbjct: 86 SIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG 145
Query: 533 HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLL 588
H + R + ++ S+ + VK+W + +++ GH G V + F +++ L
Sbjct: 146 HSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLA 205
Query: 589 SGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLF----LRVISACADGKIRIYNFFN 644
SGS+D + W + K++ P V S+LF + S C D +R+Y +
Sbjct: 206 SGSSDRTIRFWDL-EKFQVVSCIEGEPGPVR--SVLFNPDGCCLYSGCQD-SLRVYGWEP 261
Query: 645 GNCMKVIKAN 654
C V+ N
Sbjct: 262 ERCFDVVLVN 271
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 77.0 bits (188), Expect = 6e-14
Identities = 67/258 (25%), Positives = 115/258 (44%), Gaps = 32/258 (12%)
Query: 426 IAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDL-KS 484
+ V+SN + +Q A + GH V AL + + S + D S+R W + K+
Sbjct: 350 VVVASNSPCLKVFELQTSACQI-LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKA 408
Query: 485 G--VCTRIFGGHQ---GTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK-TFRHKDPIL 538
G +C GH GT+ C L ++ LV+G +DC VK+W + K T PIL
Sbjct: 409 GQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPIL 468
Query: 539 -----------------ATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLF 581
A ND + + + K+W + QL+ SGH + C+
Sbjct: 469 LQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQ 528
Query: 582 FDQWH--LLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDVSLLF--LRVISACADGK 636
F L + S DG + W++ + CL F+ H VL V+ + +++S+ +DG
Sbjct: 529 FSPMDQVLATASADGTIKLWAL--QDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGL 586
Query: 637 IRIYNFFNGNCMKVIKAN 654
++++ N C++ + A+
Sbjct: 587 VKLWTIKNNECVRTLDAH 604
Score = 71.6 bits (174), Expect = 2e-12
Identities = 49/178 (27%), Positives = 81/178 (45%), Gaps = 9/178 (5%)
Query: 450 RGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK--NR 507
R H + ++ + + L +GS D + + W L +F GH+ + C+
Sbjct: 476 RCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQV 535
Query: 508 LVSGGRDCQVKVWDVDTGKCLKTFRHKDPIL---ATRINDTYIVSSCERGLVKVWHIAMA 564
L + D +K+W + CLKTF D + A T ++SS GLVK+W I
Sbjct: 536 LATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNN 595
Query: 565 QLVKTLSGHEGAV---KCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFKHPKEVL 619
+ V+TL HE V C D H L+G++D V+ W V + E+ + ++V+
Sbjct: 596 ECVRTLDAHEDKVWGLHCSRLDD-HALTGASDSRVILWKDVTEAEQAEEQARQEEQVV 652
Score = 50.8 bits (120), Expect = 5e-06
Identities = 57/255 (22%), Positives = 98/255 (38%), Gaps = 34/255 (13%)
Query: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
+G L V R +++L++ + + + A L + L++ S L + W
Sbjct: 35 TGQHLFCVCGTR-VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQW 93
Query: 481 DLKSGVCTRIFGG-HQGTITCM--DLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR----- 532
+ G TR++ H + M D L +GG D V+VWD+ FR
Sbjct: 94 AWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGV 153
Query: 533 ------HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQ 584
H DP TR+ + SS ++VW + + L+ H AV L F D
Sbjct: 154 VHLVAFHPDP---TRL---LLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADG 207
Query: 585 WHLLSGSTDGLVMAWSMVG-----------KYERCLMAFKHPKEVLDVSLLFLRVISACA 633
+LS D + + W + E ++ + P L V L ++A
Sbjct: 208 HTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGD 267
Query: 634 DGKIRIYNFFNGNCM 648
G +R++ +G C+
Sbjct: 268 QGTLRVWEAASGQCV 282
Score = 34.7 bits (78), Expect = 0.33
Identities = 18/74 (24%), Positives = 32/74 (43%), Gaps = 2/74 (2%)
Query: 449 FRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK--N 506
F GH SV + LLS D ++ W +K+ C R H+ + + + +
Sbjct: 559 FEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDD 618
Query: 507 RLVSGGRDCQVKVW 520
++G D +V +W
Sbjct: 619 HALTGASDSRVILW 632
Score = 33.1 bits (74), Expect = 0.97
Identities = 45/191 (23%), Positives = 83/191 (43%), Gaps = 32/191 (16%)
Query: 516 QVKVWDVDTGKCLKTFRHKDPILATRIN---DTYIVSSCERGLVKV---WHI-AMAQLVK 568
+V + +V +G L++ +D T + D ++ + R L+ W ++ +L K
Sbjct: 46 RVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWK 105
Query: 569 TLSGHEGAVKCLFFDQWHLL--SGSTDGLVMAWSMVGKYERC----------LMAFKHPK 616
+ H V + FD L +G DG V W +V Y L+AF HP
Sbjct: 106 AI--HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAF-HP- 161
Query: 617 EVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPVLSFFIQGNRISVCHIS 676
D + L L S+ D IR+++ + +C+ V+ A+ L+F G+ + +S
Sbjct: 162 ---DPTRLLL--FSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTM----LS 212
Query: 677 TFAKRINVGWN 687
+ +I + W+
Sbjct: 213 SGRDKICIIWD 223
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 76.6 bits (187), Expect = 8e-14
Identities = 59/214 (27%), Positives = 91/214 (42%), Gaps = 20/214 (9%)
Query: 400 CG-TYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRA 458
CG Y+ R L+D+ L++ S + I D+ V ++GHA V
Sbjct: 342 CGPVYSTRFLADS-----------SGLLSCSEDMSIRYWDLGSFTNT-VLYQGHAYPVWD 389
Query: 459 LFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDL--CKNRLVSGGRDCQ 516
L + + SGS+D + R W RI+ GH + C+ N L +G D
Sbjct: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
Query: 517 VKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGH 573
V++W G ++ F H+ P+L+ N Y+ S+ E +K+W +A L K L GH
Sbjct: 450 VRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGH 509
Query: 574 EGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKY 605
+ L F D + S S D V W + Y
Sbjct: 510 TDNITSLTFSPDSGLIASASMDNSVRVWDIRNTY 543
Score = 36.6 bits (83), Expect = 0.088
Identities = 17/68 (25%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
+G L + ++++ L D+ + E RGH ++ +L + + S S D S+R W
Sbjct: 479 NGKYLASAGEDQRLKLWDLAS-GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
Query: 481 DLKSGVCT 488
D+++ C+
Sbjct: 538 DIRNTYCS 545
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 75.1 bits (183), Expect = 2e-13
Identities = 62/245 (25%), Positives = 108/245 (44%), Gaps = 13/245 (5%)
Query: 382 AYQNEETQQVLMEERNVFCGTYNVRILSDTWDQNRV----IHYSGGDLIAVSSNRKIHLL 437
A Q + T L++ C + I+ + + V H +G L + +R I L
Sbjct: 34 AGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLW 93
Query: 438 DIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGT 497
++ +GH+G+V L + + L S S D ++ WD ++G + GH
Sbjct: 94 NVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSF 153
Query: 498 I-TCMDLCK--NRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDT--YIVSSCE 552
+ +C + + +G D VK+WD+ ++TF++ +LA NDT I+S
Sbjct: 154 VNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGI 213
Query: 553 RGLVKVWHIAMAQLVKTLSGHEGAVK--CLFFDQWHLLSGSTDGLVMAWSM--VGKYERC 608
+KVW + +L T+ GH +V L + +LLS + D V W + ERC
Sbjct: 214 DNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC 273
Query: 609 LMAFK 613
+ F+
Sbjct: 274 VKIFQ 278
Score = 49.7 bits (117), Expect = 1e-05
Identities = 48/187 (25%), Positives = 84/187 (44%), Gaps = 16/187 (8%)
Query: 422 GGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 481
G L+ S+ L I+ KA F+ + V A+ + + ++SG D I+ WD
Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWD 221
Query: 482 LKSGVCTRIFGGHQGTITCMDLCK--NRLVSGGRDCQVKVWDV----DTGKCLKTFR--- 532
L+ T GH ++T + L + L+S D V+VWDV +C+K F+
Sbjct: 222 LRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNV 281
Query: 533 ---HKDPILATRIND-TYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWH 586
K+ + + D + I + V VW +++ L GH G++ + F D+
Sbjct: 282 HNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341
Query: 587 LLSGSTD 593
++S S+D
Sbjct: 342 IISASSD 348
Score = 46.2 bits (108), Expect = 1e-04
Identities = 46/158 (29%), Positives = 73/158 (46%), Gaps = 27/158 (17%)
Query: 399 FCGTYNVRILS--DTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSV 456
F TY V ++ DT DQ +I+ + I + D+ Q K + RGHA SV
Sbjct: 190 FQNTYQVLAVTFNDTSDQ----------IISGGIDNDIKVWDLRQNK-LTYTMRGHADSV 238
Query: 457 RALFLCEEENFLLSGSYDLSIRYWDLKSGV----CTRIFGGH-----QGTITC-MDLCKN 506
L L E ++LLS + D ++R WD++ C +IF G+ + + C +
Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGS 298
Query: 507 RLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRIND 544
++ +G D V VWD + + L +K P A IN+
Sbjct: 299 KIAAGSADRFVYVWDTTSRRIL----YKLPGHAGSINE 332
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 73.9 bits (180), Expect = 5e-13
Identities = 58/205 (28%), Positives = 88/205 (42%), Gaps = 21/205 (10%)
Query: 452 HAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNR--LV 509
H V + LC L+S S D +++ W+ G C H+ + + K++ +
Sbjct: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVA 133
Query: 510 SGGRDCQVKVWDVDTGKCLKTFR----------HKDPILATRIND--TYIVSSCERGLVK 557
S G D Q+ +WDV+T L +KD I + +N T IVS +++
Sbjct: 134 SAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLR 193
Query: 558 VWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKYERCLMAFKHP 615
VW + L GH VK L D LSGS+DG + WS+ +RC+ ++
Sbjct: 194 VWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL--GQQRCIATYRVH 251
Query: 616 KE---VLDVSLLFLRVISACADGKI 637
E L V+ F V S D KI
Sbjct: 252 DEGVWALQVNDAFTHVYSGGRDRKI 276
Score = 40.4 bits (93), Expect = 0.006
Identities = 28/102 (27%), Positives = 47/102 (46%), Gaps = 2/102 (1%)
Query: 423 GDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDL 482
G +I S K+ + + A ++ +GH +V+AL L + LSGS D +IR W L
Sbjct: 180 GTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL 239
Query: 483 KSGVCTRIFGGHQGTITCMDL--CKNRLVSGGRDCQVKVWDV 522
C + H + + + + SGGRD ++ D+
Sbjct: 240 GQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDL 281
Score = 39.7 bits (91), Expect = 0.010
Identities = 30/116 (25%), Positives = 51/116 (43%), Gaps = 22/116 (18%)
Query: 501 MDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATR------INDTY-------I 547
+D NRL + GRD +++W V+ K +DP +A+ +ND +
Sbjct: 38 LDPALNRLFTAGRDSIIRIWSVNQHK-------QDPYIASMEHHTDWVNDIVLCCNGKTL 90
Query: 548 VSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSM 601
+S+ VKVW+ + TL H+ VK L + D+ + S D + W +
Sbjct: 91 ISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDV 146
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 73.6 bits (179), Expect = 6e-13
Identities = 52/163 (31%), Positives = 79/163 (48%), Gaps = 12/163 (7%)
Query: 450 RGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKN--R 507
RGH+ V + + + F LSGS+D ++R WDL +G TR F GH + + + +
Sbjct: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119
Query: 508 LVSGGRDCQVKVWDVDTGKCLKTFR---HKDPILATRI----NDTYIVSSCERGLVKVWH 560
+VSG RD +K+W+ G C T + H + + R ++ IVS LVKVW+
Sbjct: 120 IVSGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178
Query: 561 IAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSM 601
+A +L GH G + + D SG DG M W +
Sbjct: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221
Score = 44.3 bits (103), Expect = 4e-04
Identities = 50/218 (22%), Positives = 90/218 (41%), Gaps = 17/218 (7%)
Query: 401 GTYNVRILSDTWDQNRVIHYSGG-DLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRAL 459
GT R + T D V S +++ S ++ I L + + V V+ H+ V +
Sbjct: 95 GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCV 154
Query: 460 FLCEEEN--FLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLV--SGGRDC 515
+ ++S +D ++ W+L + GH G + + + + + SGG+D
Sbjct: 155 RFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDG 214
Query: 516 QVKVWDVDTGKCLKTFRHKDPILATRIN-DTYIVSSCERGLVKVWHI-------AMAQLV 567
Q +WD++ GK L T D I A + + Y + + +K+W + + Q V
Sbjct: 215 QAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEV 274
Query: 568 KTLSGHEGAVKCLFF----DQWHLLSGSTDGLVMAWSM 601
+ S +C D L +G TD LV W +
Sbjct: 275 ISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
Score = 30.8 bits (68), Expect = 4.8
Identities = 24/124 (19%), Positives = 49/124 (39%), Gaps = 13/124 (10%)
Query: 493 GHQGTITCMDLCK---NRLVSGGRDCQVKVWDVDTG--------KCLKTFRHKDPILATR 541
GH G +T + + ++S RD + +W + + L+ H +
Sbjct: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72
Query: 542 INDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAW 599
+ + +S G +++W + + GH V + F D ++SGS D + W
Sbjct: 73 SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132
Query: 600 SMVG 603
+ +G
Sbjct: 133 NTLG 136
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 72.8 bits (177), Expect = 1e-12
Identities = 58/244 (23%), Positives = 106/244 (43%), Gaps = 24/244 (9%)
Query: 429 SSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCT 488
+SN +L +++ +P+ + L + + ++GSYD + + WD SG
Sbjct: 77 NSNHTFYLFKVLKAHILPLT---------NVALNKSGSCFITGSYDRTCKLWDTASGEEL 127
Query: 489 RIFGGHQGTITCMDLCK---NRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRIN- 543
GH+ + + +++ +G D K+W V+TGKC TFR H I+ N
Sbjct: 128 NTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNP 187
Query: 544 -DTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQW--HLLSGSTDGLVMAWS 600
T + + K+W I + V TL GH + L F+ +++GS D V+ W
Sbjct: 188 QSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Query: 601 M-VGKYERCLMAFKHPKEVLDVSLLF--LRVISACADGKIRIYNFFNGNCMKVIKANGRG 657
G+ L+ H E+ S + +++ D ++++ NG C+ + G
Sbjct: 248 ADTGRKVNILIG--HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATL--TGHD 303
Query: 658 DPVL 661
D +L
Sbjct: 304 DEIL 307
Score = 72.0 bits (175), Expect = 2e-12
Identities = 64/271 (23%), Positives = 116/271 (42%), Gaps = 22/271 (8%)
Query: 423 GDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDL 482
GD IA S K L ++ FRGH + L + + +GS D + + WD+
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
Query: 483 KSGVCTRIFGGHQGTITCM--DLCKNRLVSGGRDCQVKVWDVDTGKCLK-TFRHKDPILA 539
++G GH I + + +R+++G D V VWD DTG+ + H I +
Sbjct: 207 QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266
Query: 540 TRIN--DTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAV--KCLFFDQWHLLSGSTDGL 595
N + I++ K+W + V TL+GH+ + C + + + S DG
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 326
Query: 596 VMAWSMVGKYERCLMAFK-HPKEVLDVSL--LFLRVISACADGKIRIYNFFNGNCMKVIK 652
+S + +C+ + H E+ +S +++ +D RI++ G C++V++
Sbjct: 327 ARIFSAATR--KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLE 384
Query: 653 ANGRGDPVLS--------FFIQGNRISVCHI 675
G D + S I G++ + C I
Sbjct: 385 --GHTDEIFSCAFNYKGNIVITGSKDNTCRI 413
Score = 48.1 bits (113), Expect = 3e-05
Identities = 28/103 (27%), Positives = 50/103 (48%), Gaps = 3/103 (2%)
Query: 420 YSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRY 479
Y+G + S++ + K I + GH G + + + N LL+GS D + R
Sbjct: 313 YTGKLIATASADGTARIFSAATRKCI-AKLEGHEGEISKISFNPQGNHLLTGSSDKTARI 371
Query: 480 WDLKSGVCTRIFGGHQGTI-TCMDLCK-NRLVSGGRDCQVKVW 520
WD ++G C ++ GH I +C K N +++G +D ++W
Sbjct: 372 WDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 71.6 bits (174), Expect = 2e-12
Identities = 46/158 (29%), Positives = 74/158 (46%), Gaps = 9/158 (5%)
Query: 451 GHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLC--KNRL 508
GH G V+ + + S S D ++R WD+ C R+ GHQ ++ + +L
Sbjct: 61 GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQL 120
Query: 509 VSGGRDCQVKVWDVDTGKCLKTF-RHKDPILATRINDTY--IVSSCERGLVKVWHIAM-- 563
SGG D +V +WDV +G+ L+ H+D I ++ + T + + V +W + M
Sbjct: 121 ASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVT 180
Query: 564 -AQLVKTLSGHEGAVKCLFFDQWHLL-SGSTDGLVMAW 599
A + L GH + CL + LL SGS D + W
Sbjct: 181 PAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIW 218
Score = 59.3 bits (142), Expect = 1e-08
Identities = 42/163 (25%), Positives = 71/163 (43%), Gaps = 13/163 (7%)
Query: 449 FRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK--- 505
F H G V + + LL+GS D + W+ +SG GGH G + C+
Sbjct: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPV---KFCRFSP 73
Query: 506 --NRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPI--LATRINDTYIVSSCERGLVKVWH 560
+ S DC V++WDV KCL+ + H+ + ++ + + S V +W
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 561 IAMAQLVKTLSGHEGAVKCLFFDQW--HLLSGSTDGLVMAWSM 601
+ Q+++ L GH +++ F L +GS D V W +
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Score = 58.5 bits (140), Expect = 2e-08
Identities = 56/223 (25%), Positives = 92/223 (41%), Gaps = 21/223 (9%)
Query: 427 AVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGV 486
+ S + + L D+ + K + V +GH SV + + L SG +D + WD++SG
Sbjct: 80 SASCDCTVRLWDVARAKCLRV-LKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
Query: 487 CTRIFGGHQGTITCMDLCK--NRLVSGGRDCQVKVWDVD------TGKCLKTFRHKDPIL 538
R+ GH+ +I D N L +G D V +WD+ + + L+ L
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
Query: 539 ATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLV 596
+ S ++ + +W + L+ L GH VK + F D+ L S +V
Sbjct: 199 CYSASGLLASGSWDK-TIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMV 257
Query: 597 MAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRI 639
W +CL K VLDV+ + DGKI +
Sbjct: 258 KVWDC--NTGKCLETL---KGVLDVA----HTCAFTPDGKILV 291
Score = 32.7 bits (73), Expect = 1.3
Identities = 29/100 (29%), Positives = 42/100 (42%), Gaps = 3/100 (3%)
Query: 567 VKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAW-SMVGKYERCLMAFKHPKEVLDVSL 623
VK H G V F D LL+GS DG V W + G+ L P + S
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
Query: 624 LFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPVLSF 663
SA D +R+++ C++V+K + R +SF
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSF 113
>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
Length = 670
Score = 70.1 bits (170), Expect = 7e-12
Identities = 46/146 (31%), Positives = 70/146 (47%), Gaps = 3/146 (2%)
Query: 449 FRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGV-CTRIFGGHQGTITCMDLCKNR 507
F GH G V L + + L SGS D +I+ WD + C + GH G + + + +
Sbjct: 392 FVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCK 451
Query: 508 LVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVSSCERGLVKVWHIAMAQ-- 565
L SG DC + VWD+ + + T R D + T ++ ++ S +KVW I +
Sbjct: 452 LYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDIVGTELK 511
Query: 566 LVKTLSGHEGAVKCLFFDQWHLLSGS 591
L K L+G V+ L Q +L SGS
Sbjct: 512 LKKELTGLNHWVRALVAAQSYLYSGS 537
Score = 64.3 bits (155), Expect = 4e-10
Identities = 45/150 (30%), Positives = 76/150 (50%), Gaps = 15/150 (10%)
Query: 385 NEETQQVLMEERNVFCGTYNVRILSD--TWDQNRVIHYSGGDL--IAVSSNR-------- 432
N + ++ + ++ G+Y + D T D V+ SGG + IAV+++
Sbjct: 520 NHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYEN 579
Query: 433 KIHLLDIIQVKAIPVEFRGHAGSVRALFLCE--EENFLLSGSYDLSIRYWDLKSGVCTRI 490
IH+ DI + + GH G+V AL + ++ + S SYD S+R W + + +CT+
Sbjct: 580 LIHVWDIESKEQVRT-LTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQT 638
Query: 491 FGGHQGTITCMDLCKNRLVSGGRDCQVKVW 520
HQG++T + + + RL SG D VKVW
Sbjct: 639 LLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
Score = 61.6 bits (148), Expect = 3e-09
Identities = 45/186 (24%), Positives = 90/186 (48%), Gaps = 9/186 (4%)
Query: 421 SGGDLIAVSSNRKIHLLDIIQVKA-IPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRY 479
S +++ S + I + DI+ + + E G VRAL + ++L SGSY +I+
Sbjct: 487 SSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQ--SYLYSGSYQ-TIKI 543
Query: 480 WDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPIL 538
WD+++ C + G++ + + + +V G + + VWD+++ + ++T H +
Sbjct: 544 WDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVY 603
Query: 539 ATRI----NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDG 594
A + + T + S+ ++VW + +TL H+G+V L + L SG+ D
Sbjct: 604 ALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDS 663
Query: 595 LVMAWS 600
V W+
Sbjct: 664 TVKVWT 669
Score = 40.0 bits (92), Expect = 0.008
Identities = 33/117 (28%), Positives = 43/117 (36%), Gaps = 40/117 (34%)
Query: 487 CTRIFGGHQGTITCMDLCK--NRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRIND 544
C F GHQG + C+ + + L SG D +KVWD T
Sbjct: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCT-------------------- 427
Query: 545 TYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSM 601
TY C+ KTL GH+G V L L SGS D ++ W +
Sbjct: 428 TY---KCQ---------------KTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDI 466
Score = 31.6 bits (70), Expect = 2.8
Identities = 25/88 (28%), Positives = 40/88 (45%), Gaps = 2/88 (2%)
Query: 569 TLSGHEGAVKCL-FFDQWHLL-SGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFL 626
T GH+G V CL + LL SGS+D + W Y+ H VL + +
Sbjct: 391 TFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGC 450
Query: 627 RVISACADGKIRIYNFFNGNCMKVIKAN 654
++ S AD I +++ N + I+A+
Sbjct: 451 KLYSGSADCTIIVWDIQNLQKVNTIRAH 478
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 70.1 bits (170), Expect = 7e-12
Identities = 52/181 (28%), Positives = 83/181 (45%), Gaps = 10/181 (5%)
Query: 451 GHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTI--TCMDLCKNRL 508
GH G VR + + + ++GS D +I+ WDL SG GH T+ + L
Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261
Query: 509 VSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTY-IVSSCER-GLVKVWHIAMAQ 565
S G D QVK WD++ K ++ + H + ++ T ++ +C R ++W +
Sbjct: 262 FSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKA 321
Query: 566 LVKTLSGHEGA---VKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVS 622
V TLSGH A V+C + +++GS D + W +V R + H K V V
Sbjct: 322 SVHTLSGHTNAVATVRCQAAEP-QIITGSHDTTIRLWDLVAGKTRVTLT-NHKKSVRAVV 379
Query: 623 L 623
L
Sbjct: 380 L 380
Score = 61.6 bits (148), Expect = 3e-09
Identities = 52/230 (22%), Positives = 100/230 (43%), Gaps = 15/230 (6%)
Query: 425 LIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKS 484
L + ++++ D+ K I + GH +V L L + L++ S D + R WD+++
Sbjct: 261 LFSCGEDKQVKCWDLEYNKVIR-HYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRT 319
Query: 485 GVCTRIFGGHQGTITCM--DLCKNRLVSGGRDCQVKVWDVDTGKCLKTF-RHKDPILATR 541
GH + + + ++++G D +++WD+ GK T HK + A
Sbjct: 320 KASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVV 379
Query: 542 INDT-YIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFD-QWHLLSGSTDGLVMAW 599
++ Y +S +K W ++ LSGH + L + L+SG+ +G + W
Sbjct: 380 LHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLW 439
Query: 600 SMVGKYE-RCLMAFKHPKEVLDVSLLFL--------RVISACADGKIRIY 640
Y + + A P + S +F R+++A AD I++Y
Sbjct: 440 DWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
Score = 61.2 bits (147), Expect = 3e-09
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 8/174 (4%)
Query: 429 SSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCT 488
S++R I + D+ K + + GH +VR + + +L S D ++ WDL+
Sbjct: 223 SADRTIKIWDLASGK-LKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVI 281
Query: 489 RIFGGHQGTITCMDL--CKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRIN-- 543
R + GH + +DL + LV+ RD ++WDV T + T H + + R
Sbjct: 282 RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAA 341
Query: 544 DTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWH--LLSGSTDGL 595
+ I++ +++W + + TL+ H+ +V+ + H SGS D +
Sbjct: 342 EPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNI 395
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 68.9 bits (167), Expect = 2e-11
Identities = 48/197 (24%), Positives = 84/197 (42%), Gaps = 18/197 (9%)
Query: 413 DQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGS 472
D N+++ SG A+ I+ F GH G V +L L + +SG+
Sbjct: 153 DDNQIVTSSGDTTCALWD---------IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGA 203
Query: 473 YDLSIRYWDLKSGVCTRIFGGHQGTIT--CMDLCKNRLVSGGRDCQVKVWDVDTGKCLKT 530
D S + WD++ G+C + F GH+ I C N +G D +++D+ + L T
Sbjct: 204 CDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMT 263
Query: 531 FRHKDPI-----LATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--D 583
+ H + I ++ + +++ + VW A L+GH+ V CL D
Sbjct: 264 YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDD 323
Query: 584 QWHLLSGSTDGLVMAWS 600
+ +GS D + W+
Sbjct: 324 GMAVATGSWDSFLKIWN 340
Score = 54.7 bits (130), Expect = 3e-07
Identities = 57/249 (22%), Positives = 108/249 (43%), Gaps = 28/249 (11%)
Query: 425 LIAVSSNRKIHLLDII---QVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 481
L++ S + K+ + D +V AIP+ + V N++ G D ++
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLR----SSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Query: 482 LKSGV----CTRIFGGHQGTITCMD-LCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKD 535
LK+ +R GH G ++C L N++V+ D +WD++TG+ TF H
Sbjct: 126 LKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTG 185
Query: 536 PILATRI-NDT--YIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVK--CLFFDQWHLLSG 590
+++ + DT ++ +C+ K+W + +T +GHE + C F + +G
Sbjct: 186 DVMSLSLAPDTRLFVSGACDAS-AKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATG 244
Query: 591 STDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRI--YNFFNGNCM 648
S D + + E LM + H + ++ +S G++ + Y+ FN N
Sbjct: 245 SDDATCRLFDLRADQE--LMTYSHDNIICGIT-----SVSFSKSGRLLLAGYDDFNCNVW 297
Query: 649 KVIKANGRG 657
+KA+ G
Sbjct: 298 DALKADRAG 306
Score = 33.9 bits (76), Expect = 0.57
Identities = 39/201 (19%), Positives = 80/201 (39%), Gaps = 31/201 (15%)
Query: 485 GVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRI-- 542
G +I+ H GT + + LVS +D ++ +WD T + H P+ ++ +
Sbjct: 53 GHLAKIYAMHWGTDSRL------LVSASQDGKLIIWDSYTTNKV----HAIPLRSSWVMT 102
Query: 543 -----NDTYIVSSCERGLVKVWHIAMAQ----LVKTLSGHEGAVKCL-FFDQWHLLSGST 592
+ Y+ + ++++ + + + L+GH G + C F D +++ S
Sbjct: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG 162
Query: 593 DGLVMAWSMVGKYERCLMAFKHPKEVLDVSL-----LFLRVISACADGKIRIYNFFNGNC 647
D W + + H +V+ +SL LF +S D ++++ G C
Sbjct: 163 DTTCALWDIETGQQTTTFT-GHTGDVMSLSLAPDTRLF---VSGACDASAKLWDVREGMC 218
Query: 648 MKVIKANGRGDPVLSFFIQGN 668
+ + + FF GN
Sbjct: 219 RQTFTGHESDINAICFFPNGN 239
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 68.2 bits (165), Expect = 3e-11
Identities = 49/197 (24%), Positives = 87/197 (44%), Gaps = 18/197 (9%)
Query: 413 DQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGS 472
D N ++ SG A+ ++ Q K + F GH G +L + + N +SG+
Sbjct: 153 DDNNIVTSSGDTTCALWD------IETGQQKTV---FVGHTGDCMSLAVSPDFNLFISGA 203
Query: 473 YDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKN--RLVSGGRDCQVKVWDVDTGKCLKT 530
D S + WD++ G C + F GH+ I + N + +G D +++D+ + L
Sbjct: 204 CDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELIC 263
Query: 531 FRHKDPI-----LATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCL--FFD 583
F H+ I +A ++ + + + VW ++ V LSGH+ V CL D
Sbjct: 264 FSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTAD 323
Query: 584 QWHLLSGSTDGLVMAWS 600
+ +GS D + W+
Sbjct: 324 GMAVATGSWDSFLKIWN 340
Score = 47.0 bits (110), Expect = 7e-05
Identities = 50/237 (21%), Positives = 98/237 (41%), Gaps = 26/237 (10%)
Query: 425 LIAVSSNRKIHLLDII---QVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 481
L++ S + K+ + D +V AIP+ + V NF+ G D ++
Sbjct: 70 LVSASQDGKLIVWDSYTTNKVHAIPLR----SSWVMTCAYAPSGNFVACGGLDNMCSIYN 125
Query: 482 LKSGV----CTRIFGGHQGTITCMD-LCKNRLVSGGRDCQVKVWDVDTGKCLKTF-RHKD 535
LKS +R H G ++C L N +V+ D +WD++TG+ F H
Sbjct: 126 LKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTG 185
Query: 536 PILATRIN---DTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVK--CLFFDQWHLLSG 590
++ ++ + +I +C+ K+W + +T +GHE + C F + + +G
Sbjct: 186 DCMSLAVSPDFNLFISGACDAS-AKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTG 244
Query: 591 STDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNC 647
S D + + E L+ F H + ++ ++ G++ + + NC
Sbjct: 245 SDDASCRLFDLRADQE--LICFSHESIICGIT-----SVAFSLSGRLLFAGYDDFNC 294
Score = 33.1 bits (74), Expect = 0.97
Identities = 39/197 (19%), Positives = 75/197 (38%), Gaps = 19/197 (9%)
Query: 489 RIFGGHQGTITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRI---- 542
R GH I M + LVS +D ++ VWD T + H P+ ++ +
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKV----HAIPLRSSWVMTCA 104
Query: 543 ---NDTYIVSSCERGLVKVWHIAMAQ----LVKTLSGHEGAVKCL-FFDQWHLLSGSTDG 594
+ ++ + ++++ + + + LS H G + C F D ++++ S D
Sbjct: 105 YAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDT 164
Query: 595 LVMAWSM-VGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKA 653
W + G+ + + L VS F IS D ++++ G C +
Sbjct: 165 TCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTG 224
Query: 654 NGRGDPVLSFFIQGNRI 670
+ + FF G I
Sbjct: 225 HESDINAICFFPNGEAI 241
>gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens]
Length = 454
Score = 67.8 bits (164), Expect = 4e-11
Identities = 89/371 (23%), Positives = 145/371 (39%), Gaps = 73/371 (19%)
Query: 275 RDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQG 334
RDF++ LP+ LS Y+L+ LD TL C VS+ W N++
Sbjct: 54 RDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQW------------------NKVI---- 91
Query: 335 SYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLME 394
S + + + V D + + K LR K + ++ ET ++
Sbjct: 92 SACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLED----HEAFETSSLIGH 147
Query: 395 ERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAG 454
V+ ++Y G L S + L D+ + + G
Sbjct: 148 SARVY-----------------ALYYKDGLLCTGSDDLSAKLWDVSTGQCV----YGIQT 186
Query: 455 SVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK--NRLVSGG 512
A +E+ + +GS+D ++ W+ SG T+ F GH G + +D + LVSG
Sbjct: 187 HTCAAVKFDEQKLV-TGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGS 245
Query: 513 RDCQVKVWDVDTGKCLKTFR-HKDPILATRIN-----------DTYIVSSCERGLVKVWH 560
D VKVW + G CL T H + + + YI+ S ++ +K+W
Sbjct: 246 ADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWP 305
Query: 561 IAM---AQLVKTLSGHEGAVKC----LFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK 613
I + +KTLS E C L FD +++ S GL W Y+ L K
Sbjct: 306 IGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQ-WDF-ASYD-ILRVIK 362
Query: 614 HPKEVLDVSLL 624
P E+ +++LL
Sbjct: 363 TP-EIANLALL 372
Score = 56.6 bits (135), Expect = 8e-08
Identities = 48/183 (26%), Positives = 80/183 (43%), Gaps = 31/183 (16%)
Query: 449 FRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRL 508
FRGH G+V ++ +E + L+SGS D +++ W L +G C GH +T + L K ++
Sbjct: 222 FRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKV 281
Query: 509 VS-----------GGRDCQVKVWDVD---TGKCLKTF---RHKDPILATRI--NDTYIVS 549
S ++K+W + KCLKT + L R+ + YIV
Sbjct: 282 KSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVC 341
Query: 550 SCERGLVKVWHIAMAQLVKTLSGHE---------GAVKCLFFDQWHL--LSGSTDGLVMA 598
S GL + W A +++ + E G + L FD +L + T+ L+
Sbjct: 342 SSALGLYQ-WDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISR 400
Query: 599 WSM 601
W +
Sbjct: 401 WPL 403
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,925,192
Number of Sequences: 37866
Number of extensions: 1214013
Number of successful extensions: 4697
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 167
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 2919
Number of HSP's gapped (non-prelim): 1038
length of query: 752
length of database: 18,247,518
effective HSP length: 110
effective length of query: 642
effective length of database: 14,082,258
effective search space: 9040809636
effective search space used: 9040809636
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.