Search of human proteins with 157426885

Search of human proteins with 157426885

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157426885 organic cation transporter like 4 [Homo sapiens]
         (594 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157426885 organic cation transporter like 4 [Homo sapiens]        1187   0.0  
gi|166064021 solute carrier family 22 (organic anion transporter...   354   1e-97
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          235   1e-61
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   222   9e-58
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   221   1e-57
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       214   2e-55
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   205   8e-53
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   204   2e-52
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          202   9e-52
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   200   3e-51
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   191   2e-48
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   191   2e-48
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           188   1e-47
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          186   5e-47
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          183   3e-46
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           182   1e-45
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   174   2e-43
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]       172   8e-43
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        170   3e-42
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          166   6e-41
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       160   2e-39
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]       157   3e-38
gi|42542386 solute carrier family 22 (organic anion/cation trans...   154   3e-37
gi|153791484 putative UST1-like organic anion transporter [Homo ...   149   7e-36
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          117   4e-26
gi|170650643 solute carrier family 22, member 23 isoform a [Homo...   115   1e-25
gi|24308167 SV2 related protein [Homo sapiens]                         98   2e-20
gi|213021148 SVOP-like isoform 1 [Homo sapiens]                        98   2e-20
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...    87   3e-17
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6...    87   4e-17

>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score = 1187 bits (3070), Expect = 0.0
 Identities = 594/594 (100%), Positives = 594/594 (100%)

Query: 1   MAGEENFKEELRSQDASRNLNQHEVAGHPHSWSLEMLLRRLRAVHTKQDDKFANLLDAVG 60
           MAGEENFKEELRSQDASRNLNQHEVAGHPHSWSLEMLLRRLRAVHTKQDDKFANLLDAVG
Sbjct: 1   MAGEENFKEELRSQDASRNLNQHEVAGHPHSWSLEMLLRRLRAVHTKQDDKFANLLDAVG 60

Query: 61  EFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLSKAEQLNLTI 120
           EFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLSKAEQLNLTI
Sbjct: 61  EFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLSKAEQLNLTI 120

Query: 121 PQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDTCQDGWIYPDAKKRSLINEFDLVCGME 180
           PQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDTCQDGWIYPDAKKRSLINEFDLVCGME
Sbjct: 121 PQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDTCQDGWIYPDAKKRSLINEFDLVCGME 180

Query: 181 TKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFF 240
           TKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFF
Sbjct: 181 TKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFF 240

Query: 241 RFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIAYSLPHWQLLF 300
           RFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIAYSLPHWQLLF
Sbjct: 241 RFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIAYSLPHWQLLF 300

Query: 301 LVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDELQLPR 360
           LVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDELQLPR
Sbjct: 301 LVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDELQLPR 360

Query: 361 KKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIME 420
           KKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIME
Sbjct: 361 KKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIME 420

Query: 421 VPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMT 480
           VPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMT
Sbjct: 421 VPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMT 480

Query: 481 ILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILSLTIISQTPSLL 540
           ILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILSLTIISQTPSLL
Sbjct: 481 ILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILSLTIISQTPSLL 540

Query: 541 PIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQIRNKVKDMKTKETSSDDV 594
           PIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQIRNKVKDMKTKETSSDDV
Sbjct: 541 PIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQIRNKVKDMKTKETSSDDV 594


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  354 bits (908), Expect = 1e-97
 Identities = 192/525 (36%), Positives = 309/525 (58%), Gaps = 20/525 (3%)

Query: 51  KFANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHL 110
           +F  +L  +G+FG FQ +L+ L  + + +S F+ FA  F+   +  +C  +W+     +L
Sbjct: 3   QFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNL 62

Query: 111 SKAEQLNLTIPQAPNGSFLTCFMYLPVPWN--LDSIIQFGLNDTDTCQDGWIYPDAKKRS 168
           S AEQL L++P    G    C M+ P P N  L  I+    N+T  C  GW YP+ +  S
Sbjct: 63  SAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPS 122

Query: 169 LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGT 228
           L NEF+LVC  +  KDT Q +FMAGL +G+L+F  + D++GR   IL  LL   + G  T
Sbjct: 123 LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLAT 182

Query: 229 AFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTG 288
           AF+ SF LY+  RF ++ +V G + S+++L TEW+    R  A++L  C F++G ++L G
Sbjct: 183 AFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAG 242

Query: 289 IAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTI 348
           +AY   +W+LL + G    +    Y W LPES RWL+ +G++ EA Q++  AASVN++ +
Sbjct: 243 LAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKL 302

Query: 349 PSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVS 408
              L+++L +P K     + LD  ++ QL KVTL++ CVWF  S  Y+ LSL++ + G+ 
Sbjct: 303 SPELMNQL-VPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLD 361

Query: 409 VHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKW 468
           V+   ++   +EVPAR   IF++Q+ GRKWS   TL+   + C++++F+P          
Sbjct: 362 VYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIP---------- 411

Query: 469 PRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAIL 528
                 +L  +  ++ ++ + + AA  T+ ++Y+AEL PT+LR TG+GLV + S  G IL
Sbjct: 412 -----ADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGIL 466

Query: 529 S--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571
           +  + ++ +  + LP+ +   L IVA  L +LLPET  Q L ++L
Sbjct: 467 TPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTL 511


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  235 bits (599), Expect = 1e-61
 Identities = 162/536 (30%), Positives = 270/536 (50%), Gaps = 50/536 (9%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKP--YCNTSWILAVGPH 109
           F+ +LD VG  G FQ   VA+  +P +  A        +FTA  P  +C      + GP 
Sbjct: 3   FSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQ--IFTAATPVHHCRPPHNASTGPW 60

Query: 110 LSKAEQLNLTIPQAPNGSFLTCFMYLPVP-WNLDSIIQFGLNDTDTCQDGWIYPDAKKRS 168
           +         +P  PNG    C  ++  P  +L +  Q  +   + C DGW+Y ++ K S
Sbjct: 61  V---------LPMGPNGKPERCLRFVHPPNASLPNDTQRAM---EPCLDGWVY-NSTKDS 107

Query: 169 LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGT 228
           ++ E+DLVC     K+ AQ +FMAG+ IG L+   ++D+ GR P +  S L L   G G 
Sbjct: 108 IVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGA 167

Query: 229 AFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRA-HAIILGHCFFAVGAVLLT 287
           AF  +F +Y+ FRF     + G  +S++ L  EW+    RA  +  LG+C +  G  +L 
Sbjct: 168 AFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC-YTFGQFILP 226

Query: 288 GIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKK- 346
           G+AY++P W+ L L   I    F    W  PES RWL++ GK  +A ++L   A  N K 
Sbjct: 227 GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK 286

Query: 347 ---------TIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFT 397
                     +  NL  E+ L + K T +   D  +   L ++T  +S  WF   + Y++
Sbjct: 287 EEGERLSLEELKLNLQKEISLAKAKYTAS---DLFRIPMLRRMTFCLSLAWFATGFAYYS 343

Query: 398 LSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFL 457
           L++ + E GV+++   ++   ++VPA+   I  L  +GR  + A  LL A    L L F+
Sbjct: 344 LAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFV 403

Query: 458 PEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGL 517
           P                +L+++  ++ +  +  L+++ +  FLYT+EL PTV+R TG+G+
Sbjct: 404 P---------------LDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGV 448

Query: 518 VSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571
            +L +  G+++S  + I  +    +P  +  + A++  S +  LPET +QPL E++
Sbjct: 449 SNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETI 504


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  222 bits (565), Expect = 9e-58
 Identities = 151/546 (27%), Positives = 265/546 (48%), Gaps = 40/546 (7%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLS 111
           F +LL  VG  G FQQ  V L  +P ++ A      +F       +C          +LS
Sbjct: 3   FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPP----ADANLS 58

Query: 112 KAEQLNLTIPQAPNGSFLTCFMYLPVPWNL---DSIIQFGLNDTDTCQDGWIYPDAKKRS 168
           K   L + +P+   G   +C  +    W L   +     G   T+ C DGWIY ++   S
Sbjct: 59  KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118

Query: 169 -LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFG 227
            ++ E+DLVC     +  AQ ++M G+ +G+++F  + D++GR   ++L+ L   + G  
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 228 TAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLT 287
            AF  +F +Y  FR     ++ G +++ ++L  EW+    RA    L    +++G  LL 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 288 GIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKK- 346
           G+AY++PHW+ L L+       F  Y W   ES RW    G++    + L   A +N K 
Sbjct: 239 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR 298

Query: 347 ---------TIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFT 397
                     + ++L  EL + +    +AS ++  +   L  + L +S +WF  S+ Y+ 
Sbjct: 299 EEGAKLSMEVLRASLQKELTMGK---GQASAMELLRCPTLRHLFLCLSMLWFATSFAYYG 355

Query: 398 LSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFL 457
           L + ++  GVS++   V+   +++PA+L    ++  +GR+ +    LL A I  LL   +
Sbjct: 356 LVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVI 415

Query: 458 PEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGL 517
           P+ +  +R                 + +L +  LAA+    FLYT EL PT++R TG+G+
Sbjct: 416 PQDQSIVRTS---------------LAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGM 460

Query: 518 VSLASVAGAILSLTIISQTPSL---LPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHS 574
            S  +  G+I+S  ++S T  L   +P+F+   + + A +++ LLPET  QPL +++   
Sbjct: 461 GSTMARVGSIVS-PLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDL 519

Query: 575 SQIRNK 580
              + K
Sbjct: 520 ESRKGK 525


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  221 bits (564), Expect = 1e-57
 Identities = 150/537 (27%), Positives = 263/537 (48%), Gaps = 40/537 (7%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLS 111
           F +LL  VG  G FQQ  V L  +P ++ A      +F       +C          +LS
Sbjct: 3   FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPP----ADANLS 58

Query: 112 KAEQLNLTIPQAPNGSFLTCFMYLPVPWNL---DSIIQFGLNDTDTCQDGWIYPDAKKRS 168
           K   L + +P+   G   +C  +    W L   +     G   T+ C DGWIY ++   S
Sbjct: 59  KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118

Query: 169 -LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFG 227
            ++ E+DLVC     +  AQ ++M G+ +G+++F  + D++GR   ++L+ L   + G  
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 228 TAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLT 287
            AF  +F +Y  FR     ++ G +++ ++L  EW+    RA    L    +++G  LL 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 288 GIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKK- 346
           G+AY++PHW+ L L+       F  Y W   ES RW    G++    + L   A +N K 
Sbjct: 239 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR 298

Query: 347 ---------TIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFT 397
                     + ++L  EL + +    +AS ++  +   L  + L +S +WF  S+ Y+ 
Sbjct: 299 EEGAKLSMEVLRASLQKELTMGK---GQASAMELLRCPTLRHLFLCLSMLWFATSFAYYG 355

Query: 398 LSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFL 457
           L + ++  GVS++   V+   +++PA+L    ++  +GR+ +    LL A I  LL   +
Sbjct: 356 LVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVI 415

Query: 458 PEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGL 517
           P+ +  +R                 + +L +  LAA+    FLYT EL PT++R TG+G+
Sbjct: 416 PQDQSIVRTS---------------LAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGM 460

Query: 518 VSLASVAGAILSLTIISQTPSL---LPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571
            S  +  G+I+S  ++S T  L   +P+F+   + + A +++ LLPET  QPL +++
Sbjct: 461 GSTMARVGSIVS-PLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTV 516


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  214 bits (544), Expect = 2e-55
 Identities = 159/553 (28%), Positives = 264/553 (47%), Gaps = 39/553 (7%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLS 111
           F +LLDA+G  G FQ    AL  +P  + A   F  +F       +C             
Sbjct: 3   FTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEASTND 62

Query: 112 KAEQLNLTIPQAPNGSFLTCFMYLPVPWNL---DSIIQFGLNDTDTCQDGWIYPDAKKRS 168
               L  TIP    G+   C  +    W L   +S I      T+ C+DGW+Y  +   S
Sbjct: 63  SGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAA--TEGCKDGWVYNRSVFPS 120

Query: 169 -LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFG 227
            ++ E+DLVC   T +D AQ ++MAG+ +G+ +F  + D++G    ++ S L L   G  
Sbjct: 121 TIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAA 180

Query: 228 TAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLT 287
           TA+ +SF  Y  FRF +  +  G  ++S+SL  EW+    R  A IL    F +G ++L 
Sbjct: 181 TAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILA 240

Query: 288 GIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVN--- 344
           G+AY +  W+ L        + F  Y W LPES RWL++ GK + A Q L   A++N   
Sbjct: 241 GVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRK 300

Query: 345 -------KKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFT 397
                  K+ + S +  E        T  S+LD  +   + KVT  +  +WF+ S  Y+ 
Sbjct: 301 EEGERLTKEVMSSYIQSEF---ASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYG 357

Query: 398 LSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFL 457
           L++ +++ G+S++    +  I+  PA L     +  +GR+ ++A  L+ A +  +  +F+
Sbjct: 358 LAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFV 417

Query: 458 PEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGL 517
           PEG   L      C A            L +  LA++    +L+T EL PT +R  G+G 
Sbjct: 418 PEGTQIL------CTAQ---------AALGKGCLASSFICVYLFTGELYPTEIRQMGMGF 462

Query: 518 VSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSS 575
            S+ +  G + +  +T + +  ++LP       AI+A     +L ETR+ PL E++   +
Sbjct: 463 ASVHARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETI---A 519

Query: 576 QIRNKVKDMKTKE 588
            +  +VK+  +K+
Sbjct: 520 AMERRVKEGSSKK 532


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  205 bits (522), Expect = 8e-53
 Identities = 157/539 (29%), Positives = 260/539 (48%), Gaps = 38/539 (7%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLS 111
           F  LL+ VG FG FQ R VAL  +P ++         F+       C      A   H  
Sbjct: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH-- 60

Query: 112 KAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSII-------QFGLND---TDTCQDGWIY 161
           +   L   +P+ P+G+  +C  +   P  L +         +  L D   T  C  GW Y
Sbjct: 61  QDVWLEAHLPREPDGTLSSCLRFA-YPQALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119

Query: 162 PDAKKRSLI-NEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLG 220
             ++  S I  E+DLVC  +     A   F AG+ +G++ F  ++D+ GR   +L++ + 
Sbjct: 120 DHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVS 179

Query: 221 LIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFA 280
            ++ G  +A   S+ ++   R     ++ G+ I  + L  EWL  EHR  A +L   F+ 
Sbjct: 180 TLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWT 239

Query: 281 VGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYA 340
            G +LL  + Y +  W+ L L   +   P I  +W +PES RWL+ +G VKEA + L + 
Sbjct: 240 GGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHC 299

Query: 341 ASVNKKTI-----PSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTY 395
           A +N + +         + ++    + V R S LD  +  +L  ++L    VWF V+++Y
Sbjct: 300 ARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSY 359

Query: 396 FTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLL 455
           + LSL +  LG++V+   ++   +E+P++L     ++  GR+ + A TLL   +      
Sbjct: 360 YGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTAL------ 413

Query: 456 FLPEGEDGLRLKWPRCPATELKS-MTILVLMLREFSLAATVTVFFLYTAELLPTVLRATG 514
                  G RL      ++++KS  T+L +M + FS AA  T  +L+T+EL PTVLR TG
Sbjct: 414 -----AFGTRL----LVSSDMKSWSTVLAVMGKAFSEAAFTTA-YLFTSELYPTVLRQTG 463

Query: 515 LGLVSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571
           +GL +L    G  L+    ++      LP      +A++A   + LLPETR   L E++
Sbjct: 464 MGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETI 522


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  204 bits (518), Expect = 2e-52
 Identities = 156/541 (28%), Positives = 261/541 (48%), Gaps = 40/541 (7%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLS 111
           F  LL+ VG FG FQ R VAL  +P ++         F+       C      A   H  
Sbjct: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH-- 60

Query: 112 KAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSII-------QFGLND---TDTCQDGWIY 161
           +   L   +P+ P+G+  +C  +   P  L +         +  L D   T  C  GW Y
Sbjct: 61  QDVWLEAHLPREPDGTLSSCLRFA-YPQALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119

Query: 162 PDAKKRSLI---NEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSL 218
             ++  S I   +++DLVC  +     A   F AG+ +G++ F  ++D+ GR   +L++ 
Sbjct: 120 DHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAY 179

Query: 219 LGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCF 278
           +  ++ G  +A   S+ ++   R     ++ G+ I  + L  EWL  EHR  A +L   F
Sbjct: 180 VSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTF 239

Query: 279 FAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLC 338
           +  G +LL  + Y +  W+ L L   +   P I  +W +PES RWL+ +G VKEA + L 
Sbjct: 240 WTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLL 299

Query: 339 YAASVNKKTI-----PSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSY 393
           + A +N + +         + ++    + V R S LD  +  +L  ++L    VWF V++
Sbjct: 300 HCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNF 359

Query: 394 TYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLL 453
           +Y+ LSL +  LG++V+   ++   +E+P++L     ++  GR+ + A TLL   +    
Sbjct: 360 SYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTAL---- 415

Query: 454 LLFLPEGEDGLRLKWPRCPATELKS-MTILVLMLREFSLAATVTVFFLYTAELLPTVLRA 512
                    G RL      ++++KS  T+L +M + FS AA  T  +L+T+EL PTVLR 
Sbjct: 416 -------AFGTRL----LVSSDMKSWSTVLAVMGKAFSEAAFTTA-YLFTSELYPTVLRQ 463

Query: 513 TGLGLVSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSES 570
           TG+GL +L    G  L+    ++      LP      +A++A   + LLPETR   L E+
Sbjct: 464 TGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPET 523

Query: 571 L 571
           +
Sbjct: 524 I 524


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  202 bits (513), Expect = 9e-52
 Identities = 154/544 (28%), Positives = 250/544 (45%), Gaps = 40/544 (7%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPY-CNTSWILAVGPHL 110
           F   L  VGEFG FQ+R+  L  +  +  AF      F+ T    Y C      A+    
Sbjct: 4   FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERC 63

Query: 111 --SKAEQLNLTIPQA----PNGSFLTCFMYLPVPWNLDSIIQFGLNDTDT---------- 154
             S  E+ N T P +    P      C  YL    N  +     L+  D           
Sbjct: 64  GWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAP 123

Query: 155 ---CQDGWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRY 211
              C+ GW Y  A   ++++EFDLVC      D  Q +   G   G+       D+ GR 
Sbjct: 124 LVPCRGGWRYAQAHS-TIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRI 182

Query: 212 PAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHA 271
              LLS LG+ + G   AF  +F +++ FRF       G  ++   + TE +  + R   
Sbjct: 183 VIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIV 242

Query: 272 IILGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVK 331
            I+   FF +G ++L GIAY +P+WQ + L   +    F+ Y W++PESPRWL+ + K  
Sbjct: 243 GIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGD 302

Query: 332 EAKQVLCYAASVNKKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTV 391
           +A Q+L   A  N K + SN   E+ +  ++V+  S LD  +  Q+ K TL++   WFT 
Sbjct: 303 KALQILRRIAKCNGKYLSSN-YSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTS 361

Query: 392 SYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWC 451
           +  Y  L +R+  +G +++    +  ++E+P  L  +  ++++GR+   A + + A + C
Sbjct: 362 AVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVAC 421

Query: 452 LLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLR 511
           L+  FLPEG     + W R            V  L    +     + +L  +EL PT LR
Sbjct: 422 LVTAFLPEG-----IAWLR----------TTVATLGRLGITMAFEIVYLVNSELYPTTLR 466

Query: 512 ATGLGLVSLASVAGAILSLTIISQTPSL---LPIFLCCVLAIVAFSLSSLLPETRDQPLS 568
             G+ L S     G I++  ++ +  ++   LP+ +  +LA +   L  LLPET+   L 
Sbjct: 467 NFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALP 526

Query: 569 ESLN 572
           E+++
Sbjct: 527 ETVD 530


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  200 bits (509), Expect = 3e-51
 Identities = 153/549 (27%), Positives = 259/549 (47%), Gaps = 38/549 (6%)

Query: 54  NLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKP--YCNTSWILAVGPHL- 110
           ++L+ VGE G FQ++  A   +  + +AF       VF    P  +C +  +  +     
Sbjct: 6   DILEQVGESGWFQKQ--AFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCG 63

Query: 111 -SKAEQLNLTIPQ-APNG-SFLTCFMYLPVPWN------LDSIIQFGLNDTDT----CQD 157
            S AE+LN T+P   P G +FL       V WN      +D +     N +      CQD
Sbjct: 64  WSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQD 123

Query: 158 GWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLS 217
           GW+Y D    S++ EF+LVC    K D  Q    AG   GSL      D+ GR   +L +
Sbjct: 124 GWVY-DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGT 182

Query: 218 LLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHC 277
           +L   + G   AF  ++   L FR        G  ++  +L TE++    R    I+   
Sbjct: 183 VLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQM 242

Query: 278 FFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVL 337
            F VG V LTG+AY+LPHW+ L L   +    F+ Y W +PESPRWL+ + +  EA +++
Sbjct: 243 AFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIM 302

Query: 338 CYAASVNKKTIPSNL-LDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYF 396
            + A  N K  P++L +  L+    +    S  D  +  +L K T ++  +WFT S  Y 
Sbjct: 303 DHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQ 362

Query: 397 TLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLF 456
            L L M     +++   +  +++E+P     +  + ++GR + +A++ L A   CL+++F
Sbjct: 363 GLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIF 422

Query: 457 LPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLG 516
           +               + +L  + I+++ +    +   + +  L  AEL PT +R  G+ 
Sbjct: 423 I---------------SPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVM 467

Query: 517 LVSLASVAGAILSLTIISQTPSL---LPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNH 573
           + S     G I++  I+ +   +   LP+ L  VL ++A  ++ LLPET+   L E++  
Sbjct: 468 VCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKD 527

Query: 574 SSQIRNKVK 582
           +  +  K K
Sbjct: 528 AENLGRKAK 536


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  191 bits (484), Expect = 2e-48
 Identities = 130/475 (27%), Positives = 225/475 (47%), Gaps = 36/475 (7%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLS 111
           F +LL  VG  G FQQ  V L  +P ++ A      +F       +C          +LS
Sbjct: 3   FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPP----ADANLS 58

Query: 112 KAEQLNLTIPQAPNGSFLTCFMYLPVPWNL---DSIIQFGLNDTDTCQDGWIYPDAKKRS 168
           K   L + +P+   G   +C  +    W L   +     G   T+ C DGWIY ++   S
Sbjct: 59  KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118

Query: 169 -LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFG 227
            ++ E+DLVC     +  AQ ++M G+ +G+++F  + D++GR   ++L+ L   + G  
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 228 TAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLT 287
            AF  +F +Y  FR     ++ G +++ ++L  EW+    RA    L    +++G  LL 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 288 GIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKK- 346
           G+AY++PHW+ L L+       F  Y W   ES RW    G++    + L   A +N K 
Sbjct: 239 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR 298

Query: 347 ---------TIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFT 397
                     + ++L  EL + +    +AS ++  +   L  + L +S +WF  S+ Y+ 
Sbjct: 299 EEGAKLSMEVLRASLQKELTMGK---GQASAMELLRCPTLRHLFLCLSMLWFATSFAYYG 355

Query: 398 LSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFL 457
           L + ++  GVS++   V+   +++PA+L    ++  +GR+ +    LL A I  LL   +
Sbjct: 356 LVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVI 415

Query: 458 PEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRA 512
           P+ +  +R                 + +L +  LAA+    FLYT EL PT++RA
Sbjct: 416 PQDQSIVRTS---------------LAVLGKGCLAASFNCIFLYTGELYPTMIRA 455


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  191 bits (484), Expect = 2e-48
 Identities = 130/475 (27%), Positives = 225/475 (47%), Gaps = 36/475 (7%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLS 111
           F +LL  VG  G FQQ  V L  +P ++ A      +F       +C          +LS
Sbjct: 3   FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPP----ADANLS 58

Query: 112 KAEQLNLTIPQAPNGSFLTCFMYLPVPWNL---DSIIQFGLNDTDTCQDGWIYPDAKKRS 168
           K   L + +P+   G   +C  +    W L   +     G   T+ C DGWIY ++   S
Sbjct: 59  KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118

Query: 169 -LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFG 227
            ++ E+DLVC     +  AQ ++M G+ +G+++F  + D++GR   ++L+ L   + G  
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 228 TAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLT 287
            AF  +F +Y  FR     ++ G +++ ++L  EW+    RA    L    +++G  LL 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 288 GIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKK- 346
           G+AY++PHW+ L L+       F  Y W   ES RW    G++    + L   A +N K 
Sbjct: 239 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR 298

Query: 347 ---------TIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFT 397
                     + ++L  EL + +    +AS ++  +   L  + L +S +WF  S+ Y+ 
Sbjct: 299 EEGAKLSMEVLRASLQKELTMGK---GQASAMELLRCPTLRHLFLCLSMLWFATSFAYYG 355

Query: 398 LSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFL 457
           L + ++  GVS++   V+   +++PA+L    ++  +GR+ +    LL A I  LL   +
Sbjct: 356 LVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVI 415

Query: 458 PEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRA 512
           P+ +  +R                 + +L +  LAA+    FLYT EL PT++RA
Sbjct: 416 PQDQSIVRTS---------------LAVLGKGCLAASFNCIFLYTGELYPTMIRA 455


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  188 bits (477), Expect = 1e-47
 Identities = 155/552 (28%), Positives = 258/552 (46%), Gaps = 42/552 (7%)

Query: 54  NLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWI--LAVGPHLS 111
           ++L+  GEF  FQ+++  L  + S   A       F+       C +  +  L++    S
Sbjct: 7   DVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWS 66

Query: 112 KAEQLNLTIP---QAPNGSFLTCFMYLPVPWN---LDSIIQFGLNDTDT-------CQDG 158
            AE+LN T+P    A   S   C  Y  V WN    D +      DT+        C+DG
Sbjct: 67  PAEELNYTVPGPGPAGEASPRQCRRY-EVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDG 125

Query: 159 WIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSL 218
           W+Y +    S++ EF+LVC      D  Q     G  IGS+    I D+ GR   +L ++
Sbjct: 126 WVY-ETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTV 184

Query: 219 LGLIIFGFGTAFMNSFHLYLFFRF--GISQSVVGYAISSISLATEWLVGEHRAHAIILGH 276
           L     G   A   ++   L FR   G+  S  G+ I  I L TE++   +R    I   
Sbjct: 185 LINAAAGVLMAISPTYTWMLIFRLIQGLV-SKAGWLIGYI-LITEFVGRRYRRTVGIFYQ 242

Query: 277 CFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQV 336
             + VG ++L G+AY+LPHW+ L     +    F+ Y W +PESPRWL+ + K  EA ++
Sbjct: 243 VAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRI 302

Query: 337 LCYAASVNKKTIPSNLLDELQLPRK--KVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYT 394
           + + A  N K++P++ L  L+L  +  K    S LD  +  Q+ K T+++   WFT S  
Sbjct: 303 IKHIAKKNGKSLPAS-LQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVL 361

Query: 395 YFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLL 454
           Y  L + M   G +++      +++E PA    I  + +IGR++  A + + A   CL  
Sbjct: 362 YQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLAS 421

Query: 455 LFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATG 514
           +F+P                +L+ + I++  L    +     +  L  AEL PT +R  G
Sbjct: 422 VFIP---------------GDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLG 466

Query: 515 LGLVSLASVAGAILSLTIISQTPSL---LPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571
           + + S     G I++  ++ +  ++   LP+ +  VL +VA  L  LLPET+ + L E++
Sbjct: 467 VHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETI 526

Query: 572 NHSSQIRNKVKD 583
             +  ++   K+
Sbjct: 527 EEAENMQRPRKN 538


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  186 bits (472), Expect = 5e-47
 Identities = 145/563 (25%), Positives = 258/563 (45%), Gaps = 38/563 (6%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYC------NTSWILA 105
           F+ LLD VG  G FQ        +  +        ++F        C      N++   +
Sbjct: 3   FSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQAS 62

Query: 106 VGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNL----DSIIQFGLNDTDTCQDGWIY 161
           +   LS    L ++IP  PN     C  +    W L     +   +   DT+ C DGW+Y
Sbjct: 63  ILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVY 122

Query: 162 PDAKKRS-LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLG 220
             +   S ++ +++LVC     K  AQ +++AG+ +G+      +D+ GR   +  S L 
Sbjct: 123 DRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQ 182

Query: 221 LIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFA 280
           + + G   AF  +F +Y  FRF ++ +V G  +++ +L  EW     R   + L    F+
Sbjct: 183 MAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFS 242

Query: 281 VGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYA 340
            G  L   +AY +  W LL LV  +       Y W L ES RWL+  G++    Q L   
Sbjct: 243 FGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRV 302

Query: 341 ASVN-KKTIPSNLLDELQLP--RKKVTR----ASVLDFCKNRQLCKVTLVMSCVWFTVSY 393
           A++N K  +   L  E+ L   R++++     AS+    +   L   T + +  WF   +
Sbjct: 303 AAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGF 362

Query: 394 TYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLL 453
           T+F L+L ++ LG ++    +   ++++PA++  + LL  +GR+ +LA +LL A +  L 
Sbjct: 363 TFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILA 422

Query: 454 LLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRAT 513
              +P                E+ ++   + +L    + A  T   +Y++EL PTVLR T
Sbjct: 423 NTLVPH---------------EMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMT 467

Query: 514 GLGLVSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571
            +GL  +A+  GAIL   + ++      LP+ +   + +++   + LLPET+  PL +++
Sbjct: 468 AVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTI 527

Query: 572 NHSSQIRNKVKDMKTKETSSDDV 594
                ++N+     T  T  + V
Sbjct: 528 ---QDVQNQAVKKATHGTLGNSV 547


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  183 bits (465), Expect = 3e-46
 Identities = 149/538 (27%), Positives = 245/538 (45%), Gaps = 34/538 (6%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWI---LAVGP 108
           F+ LL+  G  G FQ   V    +P +M    M  ++F        C T  +    AV  
Sbjct: 3   FSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVST 62

Query: 109 HLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNL----DSIIQFGLNDTDTCQDGWIYPDA 164
           +++    L ++IP  PN     C  +    W L     +   +   DT+ C DGW+Y  +
Sbjct: 63  NMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRS 122

Query: 165 KKRS-LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLII 223
              S ++ ++DLVC  +  K  +Q +FM+G+ +GS I+ L++ + GR P +    L L +
Sbjct: 123 VFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAV 182

Query: 224 FGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGA 283
            G  T F  +F +Y   RF  +  + G  +SS++L  EW     RA  + +  C F+ G 
Sbjct: 183 AGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQ 242

Query: 284 VLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASV 343
             L G+A++L  W+ L L   +         W LPES RWL++KGK  +A Q L   A +
Sbjct: 243 AALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARI 302

Query: 344 NKKTIPSNLLDELQLPRKKVTRA------SVLDFCKNRQLCKVTLVMSCVWFTVSYTYFT 397
           N      NL  E+ +   K   A      SVLD      L   +  M  V F++  +Y+ 
Sbjct: 303 NGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYG 362

Query: 398 LSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFL 457
           L   ++ LG  +     +   ++   R     LL  +GR+   A +   A +  L  + +
Sbjct: 363 LVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLV 422

Query: 458 PEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGL 517
           P+               +L+++ ++  +L +     ++T   +Y AEL PT +R T  G+
Sbjct: 423 PQ---------------DLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGI 467

Query: 518 VSLASVAGAILSLTII--SQTPSLLPIFLCCVLAIVAFSLSSL--LPETRDQPLSESL 571
           +      GA++   I+   Q   LLP  L  V++I A SL  L  LPET+  PL +++
Sbjct: 468 LHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISI-ASSLVVLFFLPETQGLPLPDTI 524


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  182 bits (461), Expect = 1e-45
 Identities = 148/555 (26%), Positives = 263/555 (47%), Gaps = 50/555 (9%)

Query: 59  VGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLSKAEQLNL 118
           +GE+G FQ+ +  L     I + F   +  F+    +  C     +    +LS A + N 
Sbjct: 11  LGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCR----VPDAANLSSAWR-NH 65

Query: 119 TIP-------QAPNGSFLTCFMY-LPVPWNLDSI-------IQFGLNDTDTCQDGWIYP- 162
           T+P       + P+    +C  Y L    N  ++       +  G  + ++C DGW +  
Sbjct: 66  TVPLRLRDGREVPH----SCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQ 121

Query: 163 DAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLI 222
           D    +++ E++LVC  + K      +F  G+ +GS I   ++D+ GR   + +++    
Sbjct: 122 DVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQT 181

Query: 223 IFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHC-FFAV 281
            F F   F  +F +++     +    +   +++  L TE L    R     LG C F+A 
Sbjct: 182 GFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAF 241

Query: 282 GAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAA 341
           G ++L   AY +  W++L +   +  +  ++  W +PESPRWL+ +G+ +EA+ ++  AA
Sbjct: 242 GYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAA 301

Query: 342 SVNKKTIPSNLLD--ELQ-LPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTL 398
             N   +PS + D  ELQ L  KK    ++LD  +   +  VT++   +W T+S  YF L
Sbjct: 302 KANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGL 361

Query: 399 SLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLP 458
           SL    L   +     + +++EVPA +    LLQ + R++S+A  L       L +  +P
Sbjct: 362 SLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVP 421

Query: 459 EGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLV 518
                           +L  +  +++M+ +F + A  ++ ++YTAEL PTV+R  G+G+ 
Sbjct: 422 ---------------PDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVS 466

Query: 519 SLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQ 576
           S AS  G+ILS     +      LP  L   L I+   L+  LPE+   PL ++++    
Sbjct: 467 STASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQML- 525

Query: 577 IRNKVKDMKTKETSS 591
              +VK MK ++T S
Sbjct: 526 ---RVKGMKHRKTPS 537


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  174 bits (442), Expect = 2e-43
 Identities = 133/478 (27%), Positives = 222/478 (46%), Gaps = 35/478 (7%)

Query: 54  NLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKP--YCNTSWILAVGPHL- 110
           ++L+ VGE G FQ++  A   +  + +AF       VF    P  +C +  +  +     
Sbjct: 6   DILEQVGESGWFQKQ--AFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCG 63

Query: 111 -SKAEQLNLTIPQ-APNG-SFLTCFMYLPVPWN------LDSIIQFGLNDTDT----CQD 157
            S AE+LN T+P   P G +FL       V WN      +D +     N +      CQD
Sbjct: 64  WSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQD 123

Query: 158 GWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLS 217
           GW+Y D    S++ EF+LVC    K D  Q    AG   GSL      D+ GR   +L +
Sbjct: 124 GWVY-DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGT 182

Query: 218 LLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHC 277
           +L   + G   AF  ++   L FR        G  ++  +L TE++    R    I+   
Sbjct: 183 VLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQM 242

Query: 278 FFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVL 337
            F VG V LTG+AY+LPHW+ L L   +    F+ Y W +PESPRWL+ + +  EA +++
Sbjct: 243 AFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIM 302

Query: 338 CYAASVNKKTIPSNL-LDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYF 396
            + A  N K  P++L +  L+    +    S  D  +  +L K T ++  +WFT S  Y 
Sbjct: 303 DHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQ 362

Query: 397 TLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLF 456
            L L M     +++   +  +++E+P     +  + ++GR + +A++ L A   CL+++F
Sbjct: 363 GLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIF 422

Query: 457 LPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATG 514
           +               + +L  + I+++ +    +   + +  L  AEL PT +   G
Sbjct: 423 I---------------SPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVG 465


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score =  172 bits (436), Expect = 8e-43
 Identities = 147/562 (26%), Positives = 259/562 (46%), Gaps = 44/562 (7%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPH-- 109
           F  LLD VG  G FQ  L+A   I +I+    +  ++F        C   W+  +     
Sbjct: 3   FDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRC---WVPLLDNDTV 59

Query: 110 -------LSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLN----DTDTCQDG 158
                  LSK + L ++IP   N     C  ++   W L  +     N    DT+ C DG
Sbjct: 60  SDNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDG 119

Query: 159 WIYPDAKKRS-LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLS 217
           W+Y  +   S ++ E+DLVC  ++ K   Q +FMAG  +G LI+  ++D++GR     L 
Sbjct: 120 WVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLC 179

Query: 218 LLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHC 277
            L L I     AF  +F +Y   RF    S +    ++  L+ EW +   R+  I++  C
Sbjct: 180 FLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLC 239

Query: 278 FFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVL 337
            ++VG +LL G+A+++  W +L L     +I      W + ES RWL++  ++ E  + L
Sbjct: 240 SYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKEL 299

Query: 338 CYAASVN-KKTIPSNLLDELQLPRKKV------TRASVLDFCKNRQLCKVTLVMSCVWFT 390
              A +N KK     L  EL     K        + S+    +  +L      +  V F 
Sbjct: 300 RRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFA 359

Query: 391 VSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIW 450
           ++  ++ L L ++ LG +V    ++   +   AR   +  L  +GR+ S  +      ++
Sbjct: 360 ITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLF 419

Query: 451 CLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVL 510
            L+  FLP+               E++ + +++  L   S++A      ++  EL+PT+L
Sbjct: 420 ILVNTFLPQ---------------EMQILRVVLATLGIGSVSAASNSASVHHNELVPTIL 464

Query: 511 RATGLGLVSLASVAGAILS---LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPL 567
           R+T  G+ +++   GA L+   +T+++ +P  LP     V  I+A  +  LLPETRD PL
Sbjct: 465 RSTVAGINAVSGRTGAALAPLLMTLMAYSPH-LPWISYGVFPILAVPVILLLPETRDLPL 523

Query: 568 SESLNHSSQIRNKVKDMKTKET 589
             ++      ++  +++K ++T
Sbjct: 524 PNTIQDVENEKDS-RNIKQEDT 544


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  170 bits (431), Expect = 3e-42
 Identities = 131/572 (22%), Positives = 258/572 (45%), Gaps = 61/572 (10%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYC------------- 98
           F  + D VG FG FQ+ L  +    +I       A  F+       C             
Sbjct: 6   FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65

Query: 99  NTSWILAVGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDT---- 154
           +++W L     L  + Q +    Q  NG            W L    +    +T +    
Sbjct: 66  HSNWSLEDTGALLSSGQKDYVTVQLQNGEI----------WELSRCSRNKRENTSSLGYE 115

Query: 155 ---------CQDGWIYP-DAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLI 204
                    C DG+IY  +  K + + +++LVC  +      Q +FM G+ +GS+ F   
Sbjct: 116 YTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYF 175

Query: 205 TDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLV 264
           +D++GR   +  +   + +FG   AF   ++ ++  RF ++    GY +       E++ 
Sbjct: 176 SDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIG 235

Query: 265 GEHRAHAIILGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWL 324
            + R  A +  H FFAVG +L+    Y +  W L  ++   + +PFI   W+LPE+P WL
Sbjct: 236 MKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWL 295

Query: 325 MMKGKVKEAKQVLCYAASVNKKT---IPSNLLDELQLP----RKKVTRASVLDFCKNRQL 377
           + +G+ +EA++++   A  N+ +   +   L  +LQ P      +V + ++     N  +
Sbjct: 296 LSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSI 355

Query: 378 CKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRK 437
            K TL +  +WFT S  +++ SL    LG + +    +  ++E+PA       + ++GR+
Sbjct: 356 TKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRR 415

Query: 438 WSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTV 497
             LA +L  + + C +++ +P+               +   + ++  M+ +F++ A   +
Sbjct: 416 TVLAYSLFCSALACGVVMVIPQ---------------KHYILGVVTAMVGKFAIGAAFGL 460

Query: 498 FFLYTAELLPTVLRATGLGLVSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSL 555
            +LYTAEL PT++R+  +G  S+     +IL+     +S     +P      +A+++  L
Sbjct: 461 IYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVL 520

Query: 556 SSLLPETRDQPLSESLNHSSQIRNKVKDMKTK 587
           +  LPET  + L+ +   ++++ ++ +   +K
Sbjct: 521 TLKLPETLGKRLATTWEEAAKLESENESKSSK 552


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  166 bits (420), Expect = 6e-41
 Identities = 120/455 (26%), Positives = 223/455 (49%), Gaps = 30/455 (6%)

Query: 145 IQFGLNDTDTCQDGWIYP-DAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRL 203
           +  G  + ++C DGW +  D    +++ E++LVC    K      +F  G+ +GS +   
Sbjct: 103 VDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQ 162

Query: 204 ITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLY--LFFRFGISQSVVGYAISSISLATE 261
           ++D+ GR   +  ++     F F   F  S+ ++  LF   G+ Q +  Y ++ I L TE
Sbjct: 163 LSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQ-ISNYVVAFI-LGTE 220

Query: 262 WLVGEHRAHAIILGHC-FFAVGAVLLTGIAYSLPHWQLLFL---VGGILVIPFISYIWIL 317
            L    R     LG C FFAVG +LL   AY +  W++L L   V G+L +P     W +
Sbjct: 221 ILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLW---WFI 277

Query: 318 PESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDEL-QLPRKKVTRASVLDFCKNRQ 376
           PESPRWL+ + + +EA+ ++  AA +N   +P+ + D + +L   K  +A +LD  + R 
Sbjct: 278 PESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRN 337

Query: 377 LCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGR 436
           +  +T++   +W   S  YF LSL    L    +    + +++E+PA +    LL+ + R
Sbjct: 338 IAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPR 397

Query: 437 KWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVT 496
           ++ +A  L       L +  +P                +   ++I ++ML +F + +  +
Sbjct: 398 RYIIAAVLFWGGGVLLFIQLVP---------------VDYYFLSIGLVMLGKFGITSAFS 442

Query: 497 VFFLYTAELLPTVLRATGLGLVSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFS 554
           + +++TAEL PT++R   +G+ S AS  G+I++     +     +LP  +   L ++   
Sbjct: 443 MLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGI 502

Query: 555 LSSLLPETRDQPLSESLNHSSQIRNKVKDMKTKET 589
           L+   PE+    L E+L    +++      KT+++
Sbjct: 503 LTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDS 537


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  160 bits (406), Expect = 2e-39
 Identities = 117/415 (28%), Positives = 196/415 (47%), Gaps = 26/415 (6%)

Query: 168 SLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFG 227
           S+ +E+ L+     K   A   F +G+ +G + F  ++D+ GR    L      I+F   
Sbjct: 96  SIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIA 155

Query: 228 TAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLT 287
             F  S+  +   RF +     G ++ +  L  E +   + A A  +G  FFAVG     
Sbjct: 156 NGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYA 215

Query: 288 GIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKT 347
            + Y +  W+ L ++  +           +PESPRWL  +G++ EA++ L   A  N+K 
Sbjct: 216 LLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKL 275

Query: 348 IPSNLLDELQLPRKKVTR--ASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMREL 405
                   L  P  +  R   S LD  + R L   TL++  +WF  S  Y+ L+L   +L
Sbjct: 276 ---KCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDL 332

Query: 406 GVSVHFRHVVPSIMEVPARLCCIFLLQQ--IGRKWSLAVTLLQAIIWCLLLLFLPEGEDG 463
           G S++    +  ++E+P+   CI+L+ Q   GRK +L+  L    + CL+++FLPE +D 
Sbjct: 333 GGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKD- 391

Query: 464 LRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASV 523
                           +  + +L + +++A   + ++YT+EL PTV+R  GLG  S+ S 
Sbjct: 392 --------TGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSR 443

Query: 524 AGAILSLTIISQTPSL------LPIFLCCVLAIVAFSLSSLLPETRDQPLSESLN 572
            G I++  I    PSL      LP  +     + +  LS LLPET + PL E+ +
Sbjct: 444 VGGIIAPFI----PSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFS 494


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score =  157 bits (396), Expect = 3e-38
 Identities = 144/567 (25%), Positives = 257/567 (45%), Gaps = 60/567 (10%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFI-PSIMSAF-FMFADHFVFTAQKPYCNTSWILAVGPH 109
           F  LL  VG  G FQ  ++ L FI PS+M     +  ++F        C   W+  +  +
Sbjct: 3   FEELLSQVGGLGRFQ--MLHLVFILPSLMLLIPHILLENFAAAIPGHRC---WVHMLDNN 57

Query: 110 ---------LSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNL----DSIIQFGLNDTDTCQ 156
                    LS+   L ++IP   N     C  ++   W L     +I      DT+ C 
Sbjct: 58  TGSGNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCV 117

Query: 157 DGWIYPDAKKRS-LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAIL 215
           DGW+Y  +   S ++ ++DLVC  ++ K   Q + + G+ +G +I   ++D+ GR   + 
Sbjct: 118 DGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILR 177

Query: 216 LSLLGLIIFGFGTAFMNSFHLYLFFRF--GISQSVVGYAISSISLA-TEWLVGEHRAHAI 272
             LL L I     AF  +F +Y   RF  G S  ++   IS+ SL  TEW+    +A  +
Sbjct: 178 WCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMII---ISNNSLPITEWIRPNSKALVV 234

Query: 273 ILGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKE 332
           IL     ++G ++L G+AY    WQ L +V  +    F      L ES RWL++  K+ E
Sbjct: 235 ILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDE 294

Query: 333 AKQVLCYAA----------SVNKKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTL 382
             + L   A          ++N + + S + +EL   + K T   V D  +N  + K   
Sbjct: 295 GLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTT---VCDLFRNPSMRKRIC 351

Query: 383 VMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAV 442
           ++  + F  +  ++   + ++ +G ++    V+   + +  R   +  L  +GR+ S  +
Sbjct: 352 ILVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQIL 411

Query: 443 TLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYT 502
            +    +  L   F+P+               E++++ + +  L     AAT +   ++ 
Sbjct: 412 FMFLVGLSILANTFVPK---------------EMQTLRVALACLGIGCSAATFSSVAVHF 456

Query: 503 AELLPTVLRATGLGLVSLASVAGAILSLTIISQTP--SLLPIFLCCVLAIVAFSLSSLLP 560
            EL+PTVLRA   G+   AS  GA L+  +++ T   + LP  +  +  I+   +  LLP
Sbjct: 457 IELIPTVLRARASGIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLP 516

Query: 561 ETRDQPLSESLNHSSQIRNKVKDMKTK 587
           ET++ PL +++     + N+ K++K K
Sbjct: 517 ETKNLPLPDTI---KDVENQKKNLKEK 540


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score =  154 bits (388), Expect = 3e-37
 Identities = 124/497 (24%), Positives = 233/497 (46%), Gaps = 36/497 (7%)

Query: 110 LSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDT----CQDGWIYPDAK 165
           LS+   L ++IP   N     C  ++   W L  +     N +D     C DGW+Y    
Sbjct: 67  LSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGWVYDRIS 126

Query: 166 KRS-LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIF 224
             S ++ E+DLVC  ++    A+ +FMAG+ +G ++   ++D+ GR   +    L + I 
Sbjct: 127 FSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIV 186

Query: 225 GFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAV 284
           G   A   +F +Y   RF    + +    ++I L  EW     +A  I LG C   +  +
Sbjct: 187 GTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFM 246

Query: 285 LLTGIAYSLPHWQLLFLVGGI-LVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAA-- 341
            L G+A+++  W +L LV  +   + F++  W+L ES RWL++  K +E  + L  AA  
Sbjct: 247 TLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLL-ESARWLIINNKPEEGLKELRKAAHR 305

Query: 342 --------SVNKKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSY 393
                   ++  + + S +  EL+  +KK  + S+ +      +CK   ++S   F    
Sbjct: 306 SGMKNARDTLTLEILKSTMKKELEAAQKK--KPSLCEMLHMPNICKRISLLSFTRFANFM 363

Query: 394 TYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLL 453
            YF L+L ++ LG +V     +   + + A     + L+ + R+ S  + +    I  L 
Sbjct: 364 AYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLA 423

Query: 454 LLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRAT 513
           ++F+P+               E++++  ++  L   + A   T+ F +  E++PT++RA 
Sbjct: 424 IIFVPQ---------------EMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRAR 468

Query: 514 GLGL-VSLASVAGAILSL-TIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571
            +G+  + A++AGA+  L  I+S     LP  +  V   ++     LLPETR++PL +++
Sbjct: 469 AMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTI 528

Query: 572 NHSSQIRNKVKDMKTKE 588
                 R   ++ K ++
Sbjct: 529 QDEKNERKDPREPKQED 545


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  149 bits (376), Expect = 7e-36
 Identities = 132/546 (24%), Positives = 244/546 (44%), Gaps = 47/546 (8%)

Query: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPH-- 109
           F +LLD VG  G FQ   +    + +++       ++F        C   W+  +     
Sbjct: 3   FQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRC---WVHILDNDTI 59

Query: 110 -------LSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLN----DTDTCQDG 158
                  LS+   L ++IP   N     C  ++   W L  +     N    DT+ C DG
Sbjct: 60  PDNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDG 119

Query: 159 WIYPDAKKRS-LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLS 217
           W+Y  +   S ++ ++DLVC  +     A+ +FMAG+ +G  ++  ++D+ GR   +  S
Sbjct: 120 WVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWS 179

Query: 218 LLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHC 277
            L L I G   AF  +  +Y   RF    +     ++++ L  EW+  +  A A+ L  C
Sbjct: 180 YLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLC 239

Query: 278 FFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVL 337
             ++G + L  +A+ +    +L LV       F  +   L ES RWL++  K +E  + L
Sbjct: 240 AASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKEL 299

Query: 338 CYAASVN----------KKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCV 387
             AA  N           + + S +  EL+  +KK    S+ +  +   +CK    +S V
Sbjct: 300 RKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKK---HSLCELLRIPNICKRICFLSFV 356

Query: 388 WFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQA 447
            F  +  ++ L+L ++ LG +V     +   + + A     + L  + R+ S  + +   
Sbjct: 357 RFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLL 416

Query: 448 IIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLP 507
               L ++F+P+               E++++ +++  L   + +  +T       EL+P
Sbjct: 417 ATCLLAIIFVPQ---------------EMQTLRVVLATLGVGAASLGITCSTAQENELIP 461

Query: 508 TVLRATGLGLV-SLASVAGAILSLTIISQTPSL-LPIFLCCVLAIVAFSLSSLLPETRDQ 565
           +++R    G+  + A++ GA+ SL +I    S  LP  +  V AI++  +  LLPETR+Q
Sbjct: 462 SIIRGRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQ 521

Query: 566 PLSESL 571
           PL +S+
Sbjct: 522 PLLDSI 527


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  117 bits (292), Expect = 4e-26
 Identities = 90/343 (26%), Positives = 161/343 (46%), Gaps = 27/343 (7%)

Query: 261 EWLVGEHRAHAIILGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPES 320
           EW     R   + L    F+ G  L   +AY +  W LL LV  +       Y W L ES
Sbjct: 2   EWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAES 61

Query: 321 PRWLMMKGKVKEAKQVLCYAASVNKK-TIPSNLLDELQLP--RKKVTR----ASVLDFCK 373
            RWL+  G++    Q L   A++N K  +   L  E+ L   R++++     AS+    +
Sbjct: 62  ARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLR 121

Query: 374 NRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQ 433
              L   T + +  WF   +T+F L+L ++ LG ++    +   ++++PA++  + LL  
Sbjct: 122 MPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSH 181

Query: 434 IGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAA 493
           +GR+ +LA +LL A +  L    +P                E+ ++   + +L    + A
Sbjct: 182 LGRRPTLAASLLLAGLCILANTLVPH---------------EMGALRSALAVLGLGGVGA 226

Query: 494 TVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIV 551
             T   +Y++EL PTVLR T +GL  +A+  GAIL   + ++      LP+ +   + ++
Sbjct: 227 AFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVL 286

Query: 552 AFSLSSLLPETRDQPLSESLNHSSQIRNKVKDMKTKETSSDDV 594
           +   + LLPET+  PL +++     ++N+     T  T  + V
Sbjct: 287 SGLAALLLPETQSLPLPDTI---QDVQNQAVKKATHGTLGNSV 326


>gi|170650643 solute carrier family 22, member 23 isoform a [Homo
           sapiens]
          Length = 686

 Score =  115 bits (288), Expect = 1e-25
 Identities = 145/559 (25%), Positives = 238/559 (42%), Gaps = 67/559 (11%)

Query: 63  GTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLSKAEQLNLTIPQ 122
           G +Q+ LV LT+IP++   F  F+D F+      +C  +     G  L+           
Sbjct: 93  GGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGA---GKGTELAGVTTTGRGGDM 149

Query: 123 APNGSFLTCFMYLPVPWN------------------LDSIIQFGLNDTDTCQDGWIYP-- 162
             N + L    +   PW                   L S    G N ++     W Y   
Sbjct: 150 G-NWTSLPTTPFATAPWEAAGNRSNSSGADGGDTPPLPSPPDKGDNASNCDCRAWDYGIR 208

Query: 163 DAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLI 222
               +++++++DLVC    K   A+   + GL  G LI   I D +GR P +L S++ ++
Sbjct: 209 AGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFIL 268

Query: 223 IFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVG 282
           IFG   A   +  ++   RF     + G  ++  +L  E      R    ++       G
Sbjct: 269 IFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAG 328

Query: 283 AVLLTGIAYSLPHWQLLFLVGGILVIPF---ISYIWILPESPRWLMMKGKVKEAKQVLCY 339
             L+ G+A     WQ+L     +++ PF   + Y  I PES RWLM   + + AK+++ +
Sbjct: 329 QFLMPGLAALCRDWQVL---QALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILH 385

Query: 340 AASVNK-------KTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVS 392
               N+       K +   L  EL    KKV    V+     R L K  +V+ CV     
Sbjct: 386 FTQKNRMNPEGDIKGVIPELEKELSRRPKKVCIVKVVG---TRNLWK-NIVVLCVNSLTG 441

Query: 393 YTY---FTLSLRMRELGVSV--HF---RHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTL 444
           Y     F  S+   E+ V +  +F    +   SI  V     C+ +++ +GR+  L + +
Sbjct: 442 YGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCV-VVRFLGRRGGLLLFM 500

Query: 445 LQAIIWCLLLLFLPEGEDGLRLKWPRCPATELK-----SMTILVLMLREFSLAATVTVFF 499
           +   +  LL L    G   L  K+ + P + +        +I   ++  F+  A  ++  
Sbjct: 501 ILTALASLLQL----GLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSV 556

Query: 500 LYTAELLPTVLRATGLGLVSLASVAGAILSLTII---SQTPSLLP--IFLCCVLAIVAFS 554
            + AE+ PTV+R  GLGLV LAS    +L+  II   +Q    L   IF CC L  +   
Sbjct: 557 FFCAEITPTVIRCGGLGLV-LASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICI 615

Query: 555 LSSLLPETRDQPLSESLNH 573
           L  LLPE+RDQ L E++++
Sbjct: 616 L--LLPESRDQNLPENISN 632


>gi|24308167 SV2 related protein [Homo sapiens]
          Length = 548

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 107/416 (25%), Positives = 194/416 (46%), Gaps = 65/416 (15%)

Query: 193 GLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYA 252
           G+   S ++  I+D+ GR   + +S+L  + +G  +AF   +   L  R G+    +G  
Sbjct: 132 GMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLR-GLVGFGIGGV 190

Query: 253 ISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIA-YSLPH--WQLLFLVGGILVIP 309
             S++L  E+L  + RA  I+L   F+A+G V    +A + +P   W+ L ++  + ++ 
Sbjct: 191 PQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLILSAVPLLL 250

Query: 310 FISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDELQLPRKKVTRASVL 369
           F    + LPES R+ ++ G  ++A   L   A+ N   +P   L +L + R++  R  + 
Sbjct: 251 FAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMP---LGKLIISRQE-DRGKMR 306

Query: 370 DFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMREL-------GVSVHFRHVV------- 415
           D          TL++  +WF+ +++Y+ L L   EL       G+S   + V        
Sbjct: 307 DLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAVEAKCSLAC 365

Query: 416 -------------PSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGED 462
                         ++ E P  L  ++++ ++GRK ++A+  +    +C LLLF+  G +
Sbjct: 366 EYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFV-IFSFCSLLLFICVGRN 424

Query: 463 GLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLAS 522
            L               T+L+ + R F ++      ++YT E+ PT  RA GLG  S  +
Sbjct: 425 VL---------------TLLLFIARAF-ISGGFQAAYVYTPEVYPTATRALGLGTCSGMA 468

Query: 523 VAGAILSLTIISQTPSLLPIFL-------CCVLAIVAFSLSSLLP-ETRDQPLSES 570
             GA+++   I+Q      ++L       CC+LA +A   S  LP ET+ + L ES
Sbjct: 469 RVGALIT-PFIAQVMLESSVYLTLAVYSGCCLLAALA---SCFLPIETKGRGLQES 520


>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
          Length = 492

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 99/411 (24%), Positives = 176/411 (42%), Gaps = 67/411 (16%)

Query: 189 MFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSV 248
           M   G  + S++F L+ D+ GR+  +L+S L    F   T+F  S+  ++F R  +   V
Sbjct: 92  MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGV 151

Query: 249 VGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIAYSL---PHWQLLFLVGGI 305
            G++   + + TE+L  ++R + + L   F+  G++L+ G+A  +     W+ L  V  I
Sbjct: 152 SGHS-QGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASI 210

Query: 306 LVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDELQLPRKKVTR 365
             I  I     +PES R+ +  G  + A   L   A +N+  +P   L E  L  K+   
Sbjct: 211 PGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL-EKRGRF 269

Query: 366 ASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMREL-------------------- 405
           A +LD     +  + TL +  +W  +S+ Y+ + L   EL                    
Sbjct: 270 ADLLD----AKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGG 325

Query: 406 --------------GVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWC 451
                           S +   ++ +I E+      I  +  +GR+ SL++T+    ++ 
Sbjct: 326 DSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFF 385

Query: 452 LLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLR 511
           LLL                   T    +   + MLR   +AA     ++YTAE+ PT +R
Sbjct: 386 LLLNI----------------CTSSAGLIGFLFMLRAL-VAANFNTVYIYTAEVYPTTMR 428

Query: 512 ATGLGLVSLASVAGAILS--LTIISQTPSLLPIF-----LCCVLAIVAFSL 555
           A G+G        GA+++  ++ +  + S+L        +C V AI AF+L
Sbjct: 429 ALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTL 479


>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 126/562 (22%), Positives = 215/562 (38%), Gaps = 76/562 (13%)

Query: 53  ANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCN------------- 99
           A +L A G FG  ++ L + +++P I+    + ++  +     P+C              
Sbjct: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRAL 64

Query: 100 ------TSWILAVGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTD 153
                  + I  +GP  + AE L +  P     S+L      P P           +   
Sbjct: 65  RGPALLDAAIPRLGPTRAPAEALGVLSP-----SYLAPLTRAPRP-----------SSWA 108

Query: 154 TCQDGWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPA 213
           +C      P          ++LVCG   K    Q+  + G  +G +I     D+ GR   
Sbjct: 109 SCSGAAAGP---------TWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAV 159

Query: 214 ILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAII 273
            + SL+     G   A   SF   L  R     ++ G  ++      E     HR    +
Sbjct: 160 FVASLVLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSM 219

Query: 274 LGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGI---LVIPFISYIWILPESPRWLMMKGKV 330
               F  VG +LL G+A  +  W+LL  +G +   L++ F  +  + PESP WL+  G+V
Sbjct: 220 GAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQV 279

Query: 331 KEAKQVLCYAASVNKKTIPSNLLDELQL-PRKKVTRASV----------LDFCKNRQLCK 379
             A+++L   A  +      + L+E  L    ++T  S           L   + R   +
Sbjct: 280 ARARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWR 339

Query: 380 VTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWS 439
             L++            +    +     + +  + + + +E  A +  +      GR+  
Sbjct: 340 NGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRR-- 397

Query: 440 LAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVL-MLREFSLAATVTVF 498
             V LL  ++  L  L L  G            A  L   T+L L +L   +  A   + 
Sbjct: 398 -PVLLLGTMVTGLASLLLLAG------------AQYLPGWTVLFLSVLGLLASRAVSALS 444

Query: 499 FLYTAELLPTVLRATGLGLVSLASVAGAILSL--TIISQTPSLLPIFLCCVLAIVAFSLS 556
            L+ AE+ PTV+R  GLGLV  A   G       T+  +    L   +   LA++A    
Sbjct: 445 SLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCV 504

Query: 557 SLLPETRDQPLSESLNHSSQIR 578
            LLPE+R + L +SL  + ++R
Sbjct: 505 LLLPESRSRGLPQSLQDADRLR 526


>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
           [Homo sapiens]
          Length = 560

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 128/559 (22%), Positives = 216/559 (38%), Gaps = 68/559 (12%)

Query: 53  ANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAV------ 106
           A +L A G FG  ++ L + +++P I+    + ++  +     P+C     L        
Sbjct: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRAL 64

Query: 107 -GPHLSKA--EQLNLTIPQAP-------NGSFLTCFMYLPVPWNLDSIIQFGLNDTDTCQ 156
            GP L  A   +L  T   +P       + S+L      P P           +   +C 
Sbjct: 65  RGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRP-----------SSWASCS 113

Query: 157 DGWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILL 216
                P          ++LVCG   K    Q+  + G  +G +I     D+ GR    + 
Sbjct: 114 GAAAGP---------TWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVA 164

Query: 217 SLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGH 276
           SL+     G   A   SF   L  R     ++ G  ++      E     HR    +   
Sbjct: 165 SLVLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAG 224

Query: 277 CFFAVGAVLLTGIAYSLPHWQLLFLVGGI---LVIPFISYIWILPESPRWLMMKGKVKEA 333
            F  VG +LL G+A  +  W+LL  +G +   L++ F  +  + PESP WL+  G+V  A
Sbjct: 225 LFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARA 284

Query: 334 KQVLCYAASVNKKTIPSNLLDELQL-PRKKVTRASV----------LDFCKNRQLCKVTL 382
           +++L   A  +      + L+E  L    ++T  S           L   + R   +  L
Sbjct: 285 RKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGL 344

Query: 383 VMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAV 442
           ++            +    +     + +  + + + +E  A +  +      GR+    V
Sbjct: 345 ILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRR---PV 401

Query: 443 TLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVL-MLREFSLAATVTVFFLY 501
            LL  ++  L  L L  G            A  L   T+L L +L   +  A   +  L+
Sbjct: 402 LLLGTMVTGLASLLLLAG------------AQYLPGWTVLFLSVLGLLASRAVSALSSLF 449

Query: 502 TAELLPTVLRATGLGLVSLASVAGAILSL--TIISQTPSLLPIFLCCVLAIVAFSLSSLL 559
            AE+ PTV+R  GLGLV  A   G    L  T+  +    L   +   LA++A     LL
Sbjct: 450 AAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLL 509

Query: 560 PETRDQPLSESLNHSSQIR 578
           PE+R + L +SL  + ++R
Sbjct: 510 PESRSRGLPQSLQDADRLR 528


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.139    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,453,247
Number of Sequences: 37866
Number of extensions: 850326
Number of successful extensions: 2739
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2527
Number of HSP's gapped (non-prelim): 91
length of query: 594
length of database: 18,247,518
effective HSP length: 108
effective length of query: 486
effective length of database: 14,157,990
effective search space: 6880783140
effective search space used: 6880783140
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.