Search of human proteins with 157426847

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157426847 protocadherin 19 isoform a [Homo sapiens]
         (1101 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157426847 protocadherin 19 isoform a [Homo sapiens]               2191   0.0  
gi|157426845 protocadherin 19 isoform b [Homo sapiens]               2184   0.0  
gi|94538350 protocadherin 17 precursor [Homo sapiens]                 983   0.0  
gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]       720   0.0  
gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]       657   0.0  
gi|14589929 protocadherin 18 precursor [Homo sapiens]                 634   0.0  
gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precurso...   543   e-154
gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precurs...   543   e-154
gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens]   494   e-139
gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo sapi...   494   e-139
gi|14196468 protocadherin gamma subfamily A, 4 isoform 2 precurs...   492   e-139
gi|11056026 protocadherin gamma subfamily A, 4 isoform 1 precurs...   492   e-139
gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precurs...   492   e-139
gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precurs...   492   e-139
gi|14165413 protocadherin alpha 4 isoform 2 precursor [Homo sapi...   489   e-138
gi|9256588 protocadherin alpha 4 isoform 1 precursor [Homo sapiens]   489   e-138
gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo sapi...   489   e-138
gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens]   489   e-138
gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo sapi...   488   e-137
gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens]   488   e-137
gi|14165419 protocadherin alpha 7 isoform 2 precursor [Homo sapi...   486   e-137
gi|9256594 protocadherin alpha 7 isoform 1 precursor [Homo sapiens]   486   e-137
gi|11128035 protocadherin gamma subfamily B, 2 isoform 1 precurs...   486   e-137
gi|14270493 protocadherin gamma subfamily B, 2 isoform 2 precurs...   486   e-137
gi|7706113 protocadherin 12 precursor [Homo sapiens]                  485   e-137
gi|14165387 protocadherin alpha 11 isoform 2 precursor [Homo sap...   483   e-136
gi|9256576 protocadherin alpha 11 isoform 1 precursor [Homo sapi...   483   e-136
gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo sap...   483   e-136
gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo sapi...   483   e-136
gi|14277685 protocadherin gamma subfamily C, 5 isoform 2 precurs...   481   e-135

>gi|157426847 protocadherin 19 isoform a [Homo sapiens]
          Length = 1101

 Score = 2191 bits (5676), Expect = 0.0
 Identities = 1101/1101 (100%), Positives = 1101/1101 (100%)

Query: 1    MESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASA 60
            MESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASA
Sbjct: 1    MESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASA 60

Query: 61   FRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIK 120
            FRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIK
Sbjct: 61   FRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIK 120

Query: 121  DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT 180
            DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT
Sbjct: 121  DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT 180

Query: 181  RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE 240
            RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE
Sbjct: 181  RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE 240

Query: 241  STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV 300
            STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV
Sbjct: 241  STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV 300

Query: 301  TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE 360
            TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE
Sbjct: 301  TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE 360

Query: 361  SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYN 420
            SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYN
Sbjct: 361  SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYN 420

Query: 421  LTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDP 480
            LTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDP
Sbjct: 421  LTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDP 480

Query: 481  DLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGL 540
            DLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGL
Sbjct: 481  DLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGL 540

Query: 541  PSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGEN 600
            PSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGEN
Sbjct: 541  PSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGEN 600

Query: 601  GRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI 660
            GRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI
Sbjct: 601  GRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI 660

Query: 661  YLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCRIAEY 720
            YLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCRIAEY
Sbjct: 661  YLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCRIAEY 720

Query: 721  SYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRR 780
            SYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRR
Sbjct: 721  SYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRR 780

Query: 781  SESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRA 840
            SESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRA
Sbjct: 781  SESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRA 840

Query: 841  HLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMP 900
            HLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMP
Sbjct: 841  HLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMP 900

Query: 901  DHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSPEHVRNIIALSIEATAADVEAYDD 960
            DHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSPEHVRNIIALSIEATAADVEAYDD
Sbjct: 901  DHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSPEHVRNIIALSIEATAADVEAYDD 960

Query: 961  CGPTKRTFATFGKDVSDHPAEERPTLKGKRTVDVTICSPKVNSVIREAGNGCEAISPVTS 1020
            CGPTKRTFATFGKDVSDHPAEERPTLKGKRTVDVTICSPKVNSVIREAGNGCEAISPVTS
Sbjct: 961  CGPTKRTFATFGKDVSDHPAEERPTLKGKRTVDVTICSPKVNSVIREAGNGCEAISPVTS 1020

Query: 1021 PLHLKSSLPTKPSVSYTIALAPPARDLEQYVNNVNNGPTRPSEAEPRGADSEKVMHEVSP 1080
            PLHLKSSLPTKPSVSYTIALAPPARDLEQYVNNVNNGPTRPSEAEPRGADSEKVMHEVSP
Sbjct: 1021 PLHLKSSLPTKPSVSYTIALAPPARDLEQYVNNVNNGPTRPSEAEPRGADSEKVMHEVSP 1080

Query: 1081 ILKEGRNKESPGVKRLKDIVL 1101
            ILKEGRNKESPGVKRLKDIVL
Sbjct: 1081 ILKEGRNKESPGVKRLKDIVL 1101


>gi|157426845 protocadherin 19 isoform b [Homo sapiens]
          Length = 1100

 Score = 2184 bits (5660), Expect = 0.0
 Identities = 1100/1101 (99%), Positives = 1100/1101 (99%), Gaps = 1/1101 (0%)

Query: 1    MESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASA 60
            MESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASA
Sbjct: 1    MESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASA 60

Query: 61   FRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIK 120
            FRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIK
Sbjct: 61   FRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIK 120

Query: 121  DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT 180
            DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT
Sbjct: 121  DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT 180

Query: 181  RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE 240
            RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE
Sbjct: 181  RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE 240

Query: 241  STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV 300
            STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV
Sbjct: 241  STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV 300

Query: 301  TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE 360
            TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE
Sbjct: 301  TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE 360

Query: 361  SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYN 420
            SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYN
Sbjct: 361  SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYN 420

Query: 421  LTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDP 480
            LTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDP
Sbjct: 421  LTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDP 480

Query: 481  DLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGL 540
            DLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGL
Sbjct: 481  DLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGL 540

Query: 541  PSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGEN 600
            PSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGEN
Sbjct: 541  PSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGEN 600

Query: 601  GRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI 660
            GRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI
Sbjct: 601  GRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI 660

Query: 661  YLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCRIAEY 720
            YLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCRIAEY
Sbjct: 661  YLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCRIAEY 720

Query: 721  SYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRR 780
            SYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRR
Sbjct: 721  SYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRR 780

Query: 781  SESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRA 840
            SESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRA
Sbjct: 781  SESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRA 840

Query: 841  HLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMP 900
            HLIK SSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMP
Sbjct: 841  HLIK-SSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMP 899

Query: 901  DHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSPEHVRNIIALSIEATAADVEAYDD 960
            DHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSPEHVRNIIALSIEATAADVEAYDD
Sbjct: 900  DHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSPEHVRNIIALSIEATAADVEAYDD 959

Query: 961  CGPTKRTFATFGKDVSDHPAEERPTLKGKRTVDVTICSPKVNSVIREAGNGCEAISPVTS 1020
            CGPTKRTFATFGKDVSDHPAEERPTLKGKRTVDVTICSPKVNSVIREAGNGCEAISPVTS
Sbjct: 960  CGPTKRTFATFGKDVSDHPAEERPTLKGKRTVDVTICSPKVNSVIREAGNGCEAISPVTS 1019

Query: 1021 PLHLKSSLPTKPSVSYTIALAPPARDLEQYVNNVNNGPTRPSEAEPRGADSEKVMHEVSP 1080
            PLHLKSSLPTKPSVSYTIALAPPARDLEQYVNNVNNGPTRPSEAEPRGADSEKVMHEVSP
Sbjct: 1020 PLHLKSSLPTKPSVSYTIALAPPARDLEQYVNNVNNGPTRPSEAEPRGADSEKVMHEVSP 1079

Query: 1081 ILKEGRNKESPGVKRLKDIVL 1101
            ILKEGRNKESPGVKRLKDIVL
Sbjct: 1080 ILKEGRNKESPGVKRLKDIVL 1100


>gi|94538350 protocadherin 17 precursor [Homo sapiens]
          Length = 1159

 Score =  983 bits (2542), Expect = 0.0
 Identities = 542/1062 (51%), Positives = 707/1062 (66%), Gaps = 53/1062 (4%)

Query: 14   ILWTQAAALINLKYSVEEEQRAGTVIANVAKDAR-EAGFALDPR------QASAFRVVSN 66
            +LW  A  L NL YSV EEQ AGTVI N+ +DAR + G     R      ++ ++RV+ N
Sbjct: 10   LLWAPALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLEN 69

Query: 67   SAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNA 126
            SAPHL+D++  SGLL TKQ+IDR+ LCR + KC +SLEV ++  EIC+IKVEI+D+NDNA
Sbjct: 70   SAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNA 129

Query: 127  PSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNE--LFGLEIKTRGDG 184
            PSF + QIE++ISE A+PGTR PL SA+DPD+G  G++TY LT ++  LFGL++K+RGDG
Sbjct: 130  PSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDG 189

Query: 185  SRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYA 244
            ++F ELV++K+LDRE Q+H++  +TALDGG+PPR  TV +++KV DSNDN+PVF   +Y 
Sbjct: 190  TKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYL 249

Query: 245  VSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGAL 304
            V +PEN+P  T VI LNA+D DEG NG+V+YSF  YV DR RELF IDP +GL+ V G L
Sbjct: 250  VELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNL 309

Query: 305  DYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPP 364
            DYEE  + E+DVQA+DLGPN IPAHCKVTV ++D NDN P I  +SV      +SE+APP
Sbjct: 310  DYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQG--ALSEAAPP 367

Query: 365  GYVIALVRVSDRDSGLNGRVQCRLL---------------GNVPFRLQE-YESFSTILVD 408
            G VIALVRV+DRDSG NG++QCR+L               G+VPF+L+E Y++F T++ D
Sbjct: 368  GTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTD 427

Query: 409  GRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTP 468
              LDRE  D+YN+TI ARDGG P L S KSF + I DENDN P F+K  Y + V ENN P
Sbjct: 428  RPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIP 487

Query: 469  GAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKA 528
            G YL SV A+DPDLG NG+VSY I+PS + D+ ++TYVS+NP +G IYALRSFN EQTKA
Sbjct: 488  GEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKA 547

Query: 529  FEFKVLAKDGGLPS-LQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLV 587
            FEFKVLAKD G P+ L+SNATVRV +LDVNDN PVI  P L N TAE+ +PRN+G+GYLV
Sbjct: 548  FEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLV 607

Query: 588  TVVKAEDYDEGENGRVTYDMTEG-DRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHD 646
            + V+A D D GE+GR+TY++ +G D   FEID  +GE+RT   F E      EL+V   D
Sbjct: 608  STVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTD 667

Query: 647  HGKTSLSASALVLIYLSPALDAQESMGSVN-------LSLIFIIALGSIAGILFVTMIFV 699
            HGK +LSA A  LI  S +    E +  VN       +SL  I+ L +I+ IL   MI +
Sbjct: 668  HGKPTLSAVA-KLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITI 726

Query: 700  AIKCKRDNKEIRTYNCRIAEYSYGH-QKKSSKKKKISKNDIRLVPRDVEETDK---MNVV 755
            A+KCKR+NKEIRTYNCRIAEYS+        KKKKI+KNDI LV  +VEE +    MNVV
Sbjct: 727  AVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAMNVMNVV 786

Query: 756  SCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPD 815
            S  SL +S  YFDY Q  LPL   RSE  +L   + N      +   H SF  QG    +
Sbjct: 787  SSPSLATSPMYFDY-QTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQGTNASE 845

Query: 816  LIINGVPLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQ 875
                 + + +T+N+  + NY+ SR   ++SSSTFKD E  SL+DSGH +SDQ DS+ D  
Sbjct: 846  TPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTN 905

Query: 876  RSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSK 935
            +   CD +V + L    TS  SQ  + +  E  +C +ECR+LGHSDRCWMP+ P   +++
Sbjct: 906  KGSCCDMSVREALKMKTTSTKSQPLEQEPEECVNCTDECRVLGHSDRCWMPQFPAANQAE 965

Query: 936  SPEHVRNIIALSIEATAADVEAYDDCGPT-KRTFATFGKDVSDHP---AEERPTLKGKRT 991
            + ++  N+   ++EA   + E Y+   PT K+TF TFGKD  +H    A  +P LK KR 
Sbjct: 966  NADYRTNLFVPTVEAN-VETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLKAKRA 1024

Query: 992  VDVTICSPKVNSVIREAGNGCEA-ISPVTSPLHLKSSLPTKP 1032
            +     SP +  V   + +  +A I P TS          KP
Sbjct: 1025 L-----SPLLQEVPSASSSPTKACIEPCTSTKGSLDGCEAKP 1061


>gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]
          Length = 1040

 Score =  720 bits (1858), Expect = 0.0
 Identities = 432/1054 (40%), Positives = 622/1054 (59%), Gaps = 103/1054 (9%)

Query: 8    VLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67
            VLLL A+LW        L Y+V+EEQ  GT + N+A+D    G  +    A  F+ V NS
Sbjct: 3    VLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDL---GLDITKLSARGFQTVPNS 59

Query: 68   APHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEV-MSSSMEICVIKVEIKDLNDNA 126
                +D+N  +G+L   +KIDR+ +C+QSP C++ LEV + + +E+  +++E+ D+NDN 
Sbjct: 60   RTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNP 119

Query: 127  PSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSR 186
            PSFP   + +EISE+A+PGTR PL+SA+DPD G+  ++ YE+TPN  F L+++T+GDG+R
Sbjct: 120  PSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNR 179

Query: 187  FAELVVEKSLDRETQSHYSFRITALDGGD----------------PP---RLGTVGLSIK 227
            FAELV+EK LDRE Q+ + + +TA+DGG                 PP   R GT  L+I+
Sbjct: 180  FAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIR 239

Query: 228  VTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRE 287
            V DSNDN P F +  Y VS+PENSPP T VI+LNA+DPDEG NG+VVYSF  +++ R RE
Sbjct: 240  VLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRARE 299

Query: 288  LFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVIN 347
            LF + P +G + V+G LDYEE  VY++ VQAKDLGPN++PAHCKV V VLD NDN P I+
Sbjct: 300  LFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEIS 359

Query: 348  LLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQ-EYESFSTIL 406
              +V      VSE A PG V+AL  V+DRDS  NG+VQC LLG+VPFRL+  ++++ TI+
Sbjct: 360  FSTVKE---AVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIV 416

Query: 407  VDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENN 466
             +  LDRE  D Y LT+ ARD G P L ++KS  V ++D NDN P FS+P Y V V ENN
Sbjct: 417  TEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENN 476

Query: 467  TPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQT 526
             PGAY+ +VSA D D G N  ++Y I+  Q++ M VFTYVSIN  +G +YALRSF++EQ 
Sbjct: 477  VPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYEQL 536

Query: 527  KAFEFKVLAKDGGLP-SLQSNATVRVIILDVNDNTPVITAP-PLINGT-AEVYIPRNSGI 583
            K F F+V A+D G P +L  NATV ++I+D NDN P I AP P  NGT A   +PR++  
Sbjct: 537  KDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEP 596

Query: 584  GYLVTVVKAEDYDEGENGRVTYDMTEG-DRGFFEIDQVNGEVRTTRTF--GESSKSSYEL 640
            GYL+T V A D D+GEN R+TY +  G +   F +D   GE+RT R        +  YEL
Sbjct: 597  GYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARRVPAKRDPQRPYEL 656

Query: 641  IVVAHDHGKTSLSASALVLIYL-SPALDAQESMG--------------------SVNLSL 679
            ++   DHG+  LS++A +++ L   A++ Q   G                    S++L+L
Sbjct: 657  VIEVRDHGQPPLSSTATLVVQLVDGAVEPQGGGGSGGGGSGEHQRPSRSGGGETSLDLTL 716

Query: 680  IFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCRIAEYSY-------------GHQK 726
            I IIALGS++ I  + MI +A++C+++ K++  Y C  ++                G Q 
Sbjct: 717  ILIIALGSVSFIFLLAMIVLAVRCQKE-KKLNIYTCLASDCCLCCCCCGGGGSTCCGRQA 775

Query: 727  KSSKKKKISKNDIRL-----VPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRS 781
            + ++KKK+SK+DI L     VP +  +          S   + NY   +Q  L     ++
Sbjct: 776  R-ARKKKLSKSDIMLVQSSNVPSNPAQVPIEESGGFGSHHHNQNY--CYQVCLTPESAKT 832

Query: 782  ESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGVPLP-ETENYSFDSNYVNSRA 840
            +  FL   + +    + ++           QQPD+I NG  L  ET++   + +Y+  R 
Sbjct: 833  DLMFLKPCSPSRSTDTEHNPCGAIVTGYTDQQPDIISNGSILSNETKHQRAELSYLVDRP 892

Query: 841  HLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMP 900
              + +SS F++ +  S KDSGH +S+Q DS+HD        +A  D+ +           
Sbjct: 893  RRV-NSSAFQEADIVSSKDSGHGDSEQGDSDHDATNR--AQSAGMDLFS----------- 938

Query: 901  DHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSPEHVRNIIALSIEATAADVEAYD- 959
                    +C EEC+ LGHSDRCWMP + +P   +     R+ + +    +  D E ++ 
Sbjct: 939  --------NCTEECKALGHSDRCWMP-SFVPSDGRQAADYRSNLHVPGMDSVPDTEVFET 989

Query: 960  -DCGP-TKRTFATFGKDVSDHPAEERPTLKGKRT 991
             +  P  +R+F+TFGK+ + H   ER  L G  T
Sbjct: 990  PEAQPGAERSFSTFGKEKALHSTLERKELDGLLT 1023


>gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]
          Length = 896

 Score =  657 bits (1695), Expect = 0.0
 Identities = 379/879 (43%), Positives = 536/879 (60%), Gaps = 76/879 (8%)

Query: 8   VLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67
           VLLL A+LW        L Y+V+EEQ  GT + N+A+D    G  +    A  F+ V NS
Sbjct: 3   VLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDL---GLDITKLSARGFQTVPNS 59

Query: 68  APHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEV-MSSSMEICVIKVEIKDLNDNA 126
               +D+N  +G+L   +KIDR+ +C+QSP C++ LEV + + +E+  +++E+ D+NDN 
Sbjct: 60  RTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNP 119

Query: 127 PSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSR 186
           PSFP   + +EISE+A+PGTR PL+SA+DPD G+  ++ YE+TPN  F L+++T+GDG+R
Sbjct: 120 PSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNR 179

Query: 187 FAELVVEKSLDRETQSHYSFRITALDGGD----------------PP---RLGTVGLSIK 227
           FAELV+EK LDRE Q+ + + +TA+DGG                 PP   R GT  L+I+
Sbjct: 180 FAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIR 239

Query: 228 VTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRE 287
           V DSNDN P F +  Y VS+PENSPP T VI+LNA+DPDEG NG+VVYSF  +++ R RE
Sbjct: 240 VLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRARE 299

Query: 288 LFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVIN 347
           LF + P +G + V+G LDYEE  VY++ VQAKDLGPN++PAHCKV V VLD NDN P I+
Sbjct: 300 LFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEIS 359

Query: 348 LLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQ-EYESFSTIL 406
             +V      VSE A PG V+AL  V+DRDS  NG+VQC LLG+VPFRL+  ++++ TI+
Sbjct: 360 FSTVKE---AVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIV 416

Query: 407 VDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENN 466
            +  LDRE  D Y LT+ ARD G P L ++KS  V ++D NDN P FS+P Y V V ENN
Sbjct: 417 TEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENN 476

Query: 467 TPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQT 526
            PGAY+ +VSA D D G N  ++Y I+  Q++ M VFTYVSIN  +G +YALRSF++EQ 
Sbjct: 477 VPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYEQL 536

Query: 527 KAFEFKVLAKDGGLP-SLQSNATVRVIILDVNDNTPVITAP-PLINGT-AEVYIPRNSGI 583
           K F F+V A+D G P +L  NATV ++I+D NDN P I AP P  NGT A   +PR++  
Sbjct: 537 KDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEP 596

Query: 584 GYLVTVVKAEDYDEGENGRVTYDMTEG-DRGFFEIDQVNGEVRTTRTF--GESSKSSYEL 640
           GYL+T V A D D+GEN R+TY +  G +   F +D   GE+RT R        +  YEL
Sbjct: 597 GYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARRVPAKRDPQRPYEL 656

Query: 641 IVVAHDHGKTSLSASALVLIYL-SPALDAQESMG--------------------SVNLSL 679
           ++   DHG+  LS++A +++ L   A++ Q   G                    S++L+L
Sbjct: 657 VIEVRDHGQPPLSSTATLVVQLVDGAVEPQGGGGSGGGGSGEHQRPSRSGGGETSLDLTL 716

Query: 680 IFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCRIAEYSY-------------GHQK 726
           I IIALGS++ I  + MI +A++C+++ K++  Y C  ++                G Q 
Sbjct: 717 ILIIALGSVSFIFLLAMIVLAVRCQKE-KKLNIYTCLASDCCLCCCCCGGGGSTCCGRQA 775

Query: 727 KSSKKKKISKNDIRL-----VPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRS 781
           + ++KKK+SK+DI L     VP +  +          S   + NY   +Q  L     ++
Sbjct: 776 R-ARKKKLSKSDIMLVQSSNVPSNPAQVPIEESGGFGSHHHNQNY--CYQVCLTPESAKT 832

Query: 782 ESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIING 820
           +  FL   + +    + ++           QQPD+I NG
Sbjct: 833 DLMFLKPCSPSRSTDTEHNPCGAIVTGYTDQQPDIISNG 871


>gi|14589929 protocadherin 18 precursor [Homo sapiens]
          Length = 1135

 Score =  634 bits (1636), Expect = 0.0
 Identities = 390/1089 (35%), Positives = 600/1089 (55%), Gaps = 68/1089 (6%)

Query: 8    VLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67
            V  LL + +       NLKY + EEQR G+VIA +++D  +    L       FR +   
Sbjct: 13   VFALLIVSFNHDVLGKNLKYRIYEEQRVGSVIARLSEDVADVLLKLPNPSTVRFRAMQRG 72

Query: 68   APHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMS---SSMEICVIKVEIKDLND 124
               L+ +N  +G +     IDR+ LC+++  C I  +V++     +++  I+VE+ D+ND
Sbjct: 73   NSPLLVVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDIND 132

Query: 125  NAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDG 184
            N+P F  + I +EISE+A+ GTRIPLDSA+DPD G   + TY L+ N+ F +E++TR DG
Sbjct: 133  NSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDG 192

Query: 185  SRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYA 244
            +++AEL+V + LDRE +S Y  ++TA D G P R G+  L I ++DSNDN+P F + +Y 
Sbjct: 193  AKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYI 252

Query: 245  VSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGAL 304
            + + ENSP  T ++ LNA+DPDEG NG++VYSF  +V+ +  E F+ID   G +T+   +
Sbjct: 253  IQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQV 312

Query: 305  DYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVS---ES 361
            DYE    YE+DVQA+DLGPNSIPAHCK+ + V+D NDN P IN+  ++    E+S   E 
Sbjct: 313  DYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEISYIFEG 372

Query: 362  APPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQE-YESFSTILVDGRLDREQHDQYN 420
             P    +ALVRV D+DSGLNG + C+L G+  F+LQ+ YE+   IL +  LDRE+  +Y+
Sbjct: 373  DPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYS 432

Query: 421  LTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDP 480
            LT+ A D G P L + K FTV I D NDN PHF +  Y+ ++ ENN+PGAY+ +V+A DP
Sbjct: 433  LTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTATDP 492

Query: 481  DLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGL 540
            DLG NG V+Y I+ S +    + TYV+I+P++G IYALR F+HE+     F V A+DGG 
Sbjct: 493  DLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGS 552

Query: 541  P-SLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGE 599
            P  L SN TV + I+D NDN PV+  P L N TAE+ IP+ +  G+ VT ++A D D G 
Sbjct: 553  PKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGV 612

Query: 600  NGRVTYDMTEG-DRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALV 658
            N  ++  +  G +   F ID  + ++ T  +      + +EL V+  D G   L    L+
Sbjct: 613  NAELSCAIVAGNEENIFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQDKGNPQLHTKVLL 672

Query: 659  --LIY-----LSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIR 711
              +I+     ++       S  S+++S+I II+LG+I  +L V M+  A +C R+ K+ R
Sbjct: 673  KCMIFEYAESVTSTAMTSVSQASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTR 732

Query: 712  TYNCRIAEYSYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQ 771
            +YNCR+AE +Y H  K    ++I K DI LVP  +  T  +     SS +SS        
Sbjct: 733  SYNCRVAESTYQHHPK-RPSRQIHKGDITLVP-TINGTLPIRSHHRSSPSSSPTL----- 785

Query: 772  QTLPLGCRRSESTFLNVENQNTRNTSANHIYHH-----SFNSQGPQQPDLIINGV----- 821
            +   +G R+S ++  ++ +  T   S+NH+  +     +  +   +Q   +++ +     
Sbjct: 786  ERGQMGSRQSHNSHQSLNSLVT--ISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQY 843

Query: 822  -PLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYC 880
             P P      +  +Y              +D++  SLKDSG  +S+  DS++D+ R    
Sbjct: 844  QPRPSFRGNKYSRSY----------RYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPI 893

Query: 881  DTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSPEHV 940
            D  + +  +    + G ++P   +     C EECR+LGHSD+CWMP    P+ S S ++ 
Sbjct: 894  DRLLGEGFSDLFLTDG-RIPAAMR----LCTEECRVLGHSDQCWMP----PLPSPSSDYR 944

Query: 941  RNIIALSIEATAADVEAYD-----------DCGPTKRTFATFGKDVSDHPAEERPTLKGK 989
             N+     E      + +            D G  K++F+TFGKD S +  +   T    
Sbjct: 945  SNMFIPGEEFPTQPQQQHPHQSLEDDAQPADSGEKKKSFSTFGKD-SPNDEDTGDTSTSS 1003

Query: 990  RTVDVTICSPKVNSVIREAGNGCEAISPVTSPLHLKSSLPTKPSVSYTIALAPPARDLEQ 1049
               +++    ++     +  + C  +    S    K  LP K +V Y   +A  A     
Sbjct: 1004 LLSEMSSVFQRLLPPSLDTYSECSEVDRSNSLERRKGPLPAK-TVGYPQGVAAWAASTHF 1062

Query: 1050 YVNNVNNGP 1058
                 N GP
Sbjct: 1063 QNPTTNCGP 1071


>gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precursor
           [Homo sapiens]
          Length = 1007

 Score =  543 bits (1400), Expect = e-154
 Identities = 300/717 (41%), Positives = 443/717 (61%), Gaps = 22/717 (3%)

Query: 4   LLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRV 63
           LLLP+LLLL +L    AA   L+YSV EEQ  G ++ NVA   R  G  L        R+
Sbjct: 24  LLLPLLLLLLLLLPGPAAS-QLRYSVPEEQAPGALVGNVA---RALGLELRRLGPGCLRI 79

Query: 64  --VSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSS-MEICVIKVEIK 120
             +   +P  ++++ +SG L   ++IDR+ LC Q P+C++SLEV++ + + +  ++VEI 
Sbjct: 80  NHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEIL 139

Query: 121 DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT 180
           D+NDN+P FP    +L++SE+ +PG R  ++SA DPD G+  VQTYEL+P+E F L++K 
Sbjct: 140 DINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKP 199

Query: 181 RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE 240
             + S+  ELV+ K LDRE  + +   +TA+DGG P R GT  +S++V D+NDN+P F +
Sbjct: 200 LQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQ 259

Query: 241 STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV 300
           STY V + E+SPP T V++LNASDPDEG+NG++ YS   Y +DR R+LF ID  +G V V
Sbjct: 260 STYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVRV 319

Query: 301 TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE 360
            G LDYEE   Y++ VQA D GP  +  HCKV V ++D NDN P + L  + S    V E
Sbjct: 320 IGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYS---PVPE 376

Query: 361 SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYN 420
           +A P  ++A++ V+D+DSG N +V   L   +PFRL  + +  T++V G LDRE+   YN
Sbjct: 377 NATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYN 436

Query: 421 LTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDP 480
           +T+ A DGG+P L S ++  V I+D NDN P F +  Y + +QENN PG  L +V A DP
Sbjct: 437 ITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDP 496

Query: 481 DLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGL 540
           D   N  V+Y ++  +++ +PV +YVSIN  SG +YA+ SF++E+ + F   V A+D G 
Sbjct: 497 DEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGS 556

Query: 541 PSLQSNATVRVIILDVNDNTPVITAPPLINGTAEV-YIPRNSGIGYLVTVVKAEDYDEGE 599
           P L S  T  V ++D+ND+ P I  P   N +A    +PR +  GYLVT V A D D G+
Sbjct: 557 PPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQ 616

Query: 600 NGRVTYDMTE-GDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALV 658
           N  + Y + +  D   F+++   GE+RTTR  G+ S S++ L VV  D+G+ SLSAS  +
Sbjct: 617 NAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAI 676

Query: 659 LIYLSPAL-----DAQESMGS----VNLSLIFIIALGSIAGILFVTMIFVA-IKCKR 705
            + +   +     D Q  + S      ++L  IIAL +++ I  +T+I ++ IKC R
Sbjct: 677 TVAVVDRVSKILPDTQRHVKSPRTYSEITLYLIIALSTVSFIFLLTIIILSIIKCYR 733


>gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precursor
           [Homo sapiens]
          Length = 884

 Score =  543 bits (1400), Expect = e-154
 Identities = 300/717 (41%), Positives = 443/717 (61%), Gaps = 22/717 (3%)

Query: 4   LLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRV 63
           LLLP+LLLL +L    AA   L+YSV EEQ  G ++ NVA   R  G  L        R+
Sbjct: 24  LLLPLLLLLLLLLPGPAAS-QLRYSVPEEQAPGALVGNVA---RALGLELRRLGPGCLRI 79

Query: 64  --VSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSS-MEICVIKVEIK 120
             +   +P  ++++ +SG L   ++IDR+ LC Q P+C++SLEV++ + + +  ++VEI 
Sbjct: 80  NHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEIL 139

Query: 121 DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT 180
           D+NDN+P FP    +L++SE+ +PG R  ++SA DPD G+  VQTYEL+P+E F L++K 
Sbjct: 140 DINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKP 199

Query: 181 RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE 240
             + S+  ELV+ K LDRE  + +   +TA+DGG P R GT  +S++V D+NDN+P F +
Sbjct: 200 LQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQ 259

Query: 241 STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV 300
           STY V + E+SPP T V++LNASDPDEG+NG++ YS   Y +DR R+LF ID  +G V V
Sbjct: 260 STYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVRV 319

Query: 301 TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE 360
            G LDYEE   Y++ VQA D GP  +  HCKV V ++D NDN P + L  + S    V E
Sbjct: 320 IGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYS---PVPE 376

Query: 361 SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYN 420
           +A P  ++A++ V+D+DSG N +V   L   +PFRL  + +  T++V G LDRE+   YN
Sbjct: 377 NATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYN 436

Query: 421 LTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDP 480
           +T+ A DGG+P L S ++  V I+D NDN P F +  Y + +QENN PG  L +V A DP
Sbjct: 437 ITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDP 496

Query: 481 DLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGL 540
           D   N  V+Y ++  +++ +PV +YVSIN  SG +YA+ SF++E+ + F   V A+D G 
Sbjct: 497 DEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGS 556

Query: 541 PSLQSNATVRVIILDVNDNTPVITAPPLINGTAEV-YIPRNSGIGYLVTVVKAEDYDEGE 599
           P L S  T  V ++D+ND+ P I  P   N +A    +PR +  GYLVT V A D D G+
Sbjct: 557 PPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQ 616

Query: 600 NGRVTYDMTE-GDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALV 658
           N  + Y + +  D   F+++   GE+RTTR  G+ S S++ L VV  D+G+ SLSAS  +
Sbjct: 617 NAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAI 676

Query: 659 LIYLSPAL-----DAQESMGS----VNLSLIFIIALGSIAGILFVTMIFVA-IKCKR 705
            + +   +     D Q  + S      ++L  IIAL +++ I  +T+I ++ IKC R
Sbjct: 677 TVAVVDRVSKILPDTQRHVKSPRTYSEITLYLIIALSTVSFIFLLTIIILSIIKCYR 733


>gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens]
          Length = 936

 Score =  494 bits (1273), Expect = e-139
 Identities = 281/748 (37%), Positives = 429/748 (57%), Gaps = 34/748 (4%)

Query: 8   VLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67
           +LLL  +L    A    L YS+ EE + GT +  +A+D       L PR    FRV S  
Sbjct: 13  LLLLWLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPR---LFRVASKG 69

Query: 68  APHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIKDLNDNA 126
              L+++N  +G+L    +IDR+ LCR+  +C I LEV+    +++  ++V +KD+NDN 
Sbjct: 70  RGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNP 129

Query: 127 PSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSR 186
           P F   +  L I E+  P +R PL+ A D D G+     Y L PNE F L++KT  + + 
Sbjct: 130 PRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDLDVKTNEEETN 189

Query: 187 FAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVS 246
           F ELV+ KSLDRE    +   + A DGG P   GTV L I V D+NDN P F +S Y V 
Sbjct: 190 FLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVR 249

Query: 247 VPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDY 306
           + EN+P  T VI+LNASD DEG N ++VY F   V D  +  F I+ ++G + V G LDY
Sbjct: 250 LLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDY 309

Query: 307 EEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGY 366
           E+ + YE+++ A D     +  HCKV V +LD NDN P    +++ +  + V E AP   
Sbjct: 310 EDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPE---MAITTLFLPVKEDAPLST 366

Query: 367 VIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQYNLTIQA 425
           VIAL+ VSDRDSG NG+V C L+ +VPF+L   ++++ ++++D  LDRE    Y L + A
Sbjct: 367 VIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTA 426

Query: 426 RDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLN 485
           RDGG P L +  S +V + D NDN P F++P Y V V+ENN PG ++ +VSARD D   N
Sbjct: 427 RDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQEN 486

Query: 486 GSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQS 545
             VSY +V  +V + P+ +YVS++  SG +YAL+  +HE+ +  +F+V A+D G+P L S
Sbjct: 487 ALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGS 546

Query: 546 NATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRV 603
           N T++V +LD NDN P +  P +    G     +PR+ G G++V  V+A D D G N  +
Sbjct: 547 NVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWL 606

Query: 604 TYDMTEGD---RGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI 660
           +Y++       R  F +    GE+ TTR+  E+    + L+V+  DHG+  L+A+A VL+
Sbjct: 607 SYELQPAPGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHGEPPLTATATVLV 666

Query: 661 YL-----SPALDAQESMGS-------VNLSLIFIIALGSIAGILFVT-MIFVAIKCKRD- 706
            L     +P   ++ S G+       V++++  IIA+ +++ +L +T +++ A++C    
Sbjct: 667 SLVESGQAPKASSRASAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAQP 726

Query: 707 -------NKEIRTYNCRIAEYSYGHQKK 727
                   K     +  +  +SY  Q++
Sbjct: 727 TEAVCTRGKPTLLCSSAVGSWSYSQQRR 754


>gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo
           sapiens]
          Length = 816

 Score =  494 bits (1273), Expect = e-139
 Identities = 281/748 (37%), Positives = 429/748 (57%), Gaps = 34/748 (4%)

Query: 8   VLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67
           +LLL  +L    A    L YS+ EE + GT +  +A+D       L PR    FRV S  
Sbjct: 13  LLLLWLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPR---LFRVASKG 69

Query: 68  APHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIKDLNDNA 126
              L+++N  +G+L    +IDR+ LCR+  +C I LEV+    +++  ++V +KD+NDN 
Sbjct: 70  RGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNP 129

Query: 127 PSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSR 186
           P F   +  L I E+  P +R PL+ A D D G+     Y L PNE F L++KT  + + 
Sbjct: 130 PRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDLDVKTNEEETN 189

Query: 187 FAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVS 246
           F ELV+ KSLDRE    +   + A DGG P   GTV L I V D+NDN P F +S Y V 
Sbjct: 190 FLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVR 249

Query: 247 VPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDY 306
           + EN+P  T VI+LNASD DEG N ++VY F   V D  +  F I+ ++G + V G LDY
Sbjct: 250 LLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDY 309

Query: 307 EEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGY 366
           E+ + YE+++ A D     +  HCKV V +LD NDN P    +++ +  + V E AP   
Sbjct: 310 EDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPE---MAITTLFLPVKEDAPLST 366

Query: 367 VIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQYNLTIQA 425
           VIAL+ VSDRDSG NG+V C L+ +VPF+L   ++++ ++++D  LDRE    Y L + A
Sbjct: 367 VIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTA 426

Query: 426 RDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLN 485
           RDGG P L +  S +V + D NDN P F++P Y V V+ENN PG ++ +VSARD D   N
Sbjct: 427 RDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQEN 486

Query: 486 GSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQS 545
             VSY +V  +V + P+ +YVS++  SG +YAL+  +HE+ +  +F+V A+D G+P L S
Sbjct: 487 ALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGS 546

Query: 546 NATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRV 603
           N T++V +LD NDN P +  P +    G     +PR+ G G++V  V+A D D G N  +
Sbjct: 547 NVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWL 606

Query: 604 TYDMTEGD---RGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI 660
           +Y++       R  F +    GE+ TTR+  E+    + L+V+  DHG+  L+A+A VL+
Sbjct: 607 SYELQPAPGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHGEPPLTATATVLV 666

Query: 661 YL-----SPALDAQESMGS-------VNLSLIFIIALGSIAGILFVT-MIFVAIKCKRD- 706
            L     +P   ++ S G+       V++++  IIA+ +++ +L +T +++ A++C    
Sbjct: 667 SLVESGQAPKASSRASAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAQP 726

Query: 707 -------NKEIRTYNCRIAEYSYGHQKK 727
                   K     +  +  +SY  Q++
Sbjct: 727 TEAVCTRGKPTLLCSSAVGSWSYSQQRR 754


>gi|14196468 protocadherin gamma subfamily A, 4 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  492 bits (1267), Expect = e-139
 Identities = 288/723 (39%), Positives = 427/723 (59%), Gaps = 33/723 (4%)

Query: 5   LLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQAS--AFR 62
           LL + LLL +L    A  I   YSV EEQ  G+V+ N+AKD       L PR+ +    R
Sbjct: 13  LLQICLLLGVLVEIRAEQI--LYSVFEEQEEGSVVGNIAKD-----LGLAPRELAERGVR 65

Query: 63  VVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIKD 121
           +VS     L  +NP SG LVT  +IDR+ LC +SP C+ +LE++   +++I  ++VEI D
Sbjct: 66  IVSRGRTQLFALNPRSGTLVTAGRIDREELCDRSPNCVTNLEILLEDTVKILRVEVEIID 125

Query: 122 LNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTR 181
           +NDN PSF   Q E++++E  +PG R PL  A+DPD G   +Q Y+L  N  F L++++ 
Sbjct: 126 VNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYFSLDVQSG 185

Query: 182 GDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSES 241
            DG ++ ELV+E++LDRE ++ +   +TA DGGDP R GT  + I + D+NDN PVF++ 
Sbjct: 186 ADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQP 245

Query: 242 TYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVT 301
            Y VSV EN P  T ++ + A+DPDEG NG V YSF   V D+  +LFQ++  SG +T+ 
Sbjct: 246 EYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSF-RKVRDKISQLFQLNSLSGDITIL 304

Query: 302 GALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSES 361
           G LDYE+   Y++DV+A D GP  + A  KV V+VLD NDN P + + S+ S    V ES
Sbjct: 305 GGLDYEDSGFYDIDVEAHD-GP-GLRARSKVLVTVLDENDNAPEVTVTSLTS---SVQES 359

Query: 362 APPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQE-YESFSTILVDGRLDREQHDQYN 420
           + PG VIAL  V D DSG NG V C +  N+PF L++ Y ++  +L    LDRE+  +YN
Sbjct: 360 SSPGTVIALFNVHDSDSGGNGLVTCSIPDNLPFTLEKTYGNYYRLLTHRTLDREEVSEYN 419

Query: 421 LTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDP 480
           +T+ A D G P L +    ++ + D NDN P F    Y   + ENN  GA +LS++A+DP
Sbjct: 420 ITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDP 479

Query: 481 DLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGL 540
           D G N  ++Y +     +  P+ +YVSIN N+G +YAL SF++EQ +  +  + A D G 
Sbjct: 480 DSGDNARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGD 539

Query: 541 PSLQSNATVRVIILDVNDNTPVITAP--PLINGTAEVYIPRNSGIGYLVTVVKAEDYDEG 598
           P L SN ++ + +LD NDN P I  P  P    T     PR++  GYLVT V A D D G
Sbjct: 540 PPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSG 599

Query: 599 ENGRVTYDMTE-GDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASAL 657
           +N  ++Y + +  + G F +    GEVRT R   +       L+VV  DHG+  LSA+  
Sbjct: 600 QNAWLSYSLLKSSEPGLFAVGLHTGEVRTARALLDRDALKQRLVVVVQDHGQPPLSATVT 659

Query: 658 VLIYLSPAL-DAQESMGSV---------NLSLIFIIALGSIAGIL--FVTMIFVAIKCKR 705
           + + ++ ++ D    +GS+          L+L  ++A+ +++ +   FVT + +A+K +R
Sbjct: 660 LTVAVADSIPDVLADLGSLKPSADPDDSGLTLYLVVAVAAVSCVFLAFVT-VLLALKLRR 718

Query: 706 DNK 708
            +K
Sbjct: 719 WHK 721


>gi|11056026 protocadherin gamma subfamily A, 4 isoform 1 precursor
           [Homo sapiens]
          Length = 931

 Score =  492 bits (1267), Expect = e-139
 Identities = 288/723 (39%), Positives = 427/723 (59%), Gaps = 33/723 (4%)

Query: 5   LLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQAS--AFR 62
           LL + LLL +L    A  I   YSV EEQ  G+V+ N+AKD       L PR+ +    R
Sbjct: 13  LLQICLLLGVLVEIRAEQI--LYSVFEEQEEGSVVGNIAKD-----LGLAPRELAERGVR 65

Query: 63  VVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIKD 121
           +VS     L  +NP SG LVT  +IDR+ LC +SP C+ +LE++   +++I  ++VEI D
Sbjct: 66  IVSRGRTQLFALNPRSGTLVTAGRIDREELCDRSPNCVTNLEILLEDTVKILRVEVEIID 125

Query: 122 LNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTR 181
           +NDN PSF   Q E++++E  +PG R PL  A+DPD G   +Q Y+L  N  F L++++ 
Sbjct: 126 VNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYFSLDVQSG 185

Query: 182 GDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSES 241
            DG ++ ELV+E++LDRE ++ +   +TA DGGDP R GT  + I + D+NDN PVF++ 
Sbjct: 186 ADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQP 245

Query: 242 TYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVT 301
            Y VSV EN P  T ++ + A+DPDEG NG V YSF   V D+  +LFQ++  SG +T+ 
Sbjct: 246 EYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSF-RKVRDKISQLFQLNSLSGDITIL 304

Query: 302 GALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSES 361
           G LDYE+   Y++DV+A D GP  + A  KV V+VLD NDN P + + S+ S    V ES
Sbjct: 305 GGLDYEDSGFYDIDVEAHD-GP-GLRARSKVLVTVLDENDNAPEVTVTSLTS---SVQES 359

Query: 362 APPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQE-YESFSTILVDGRLDREQHDQYN 420
           + PG VIAL  V D DSG NG V C +  N+PF L++ Y ++  +L    LDRE+  +YN
Sbjct: 360 SSPGTVIALFNVHDSDSGGNGLVTCSIPDNLPFTLEKTYGNYYRLLTHRTLDREEVSEYN 419

Query: 421 LTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDP 480
           +T+ A D G P L +    ++ + D NDN P F    Y   + ENN  GA +LS++A+DP
Sbjct: 420 ITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDP 479

Query: 481 DLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGL 540
           D G N  ++Y +     +  P+ +YVSIN N+G +YAL SF++EQ +  +  + A D G 
Sbjct: 480 DSGDNARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGD 539

Query: 541 PSLQSNATVRVIILDVNDNTPVITAP--PLINGTAEVYIPRNSGIGYLVTVVKAEDYDEG 598
           P L SN ++ + +LD NDN P I  P  P    T     PR++  GYLVT V A D D G
Sbjct: 540 PPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSG 599

Query: 599 ENGRVTYDMTE-GDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASAL 657
           +N  ++Y + +  + G F +    GEVRT R   +       L+VV  DHG+  LSA+  
Sbjct: 600 QNAWLSYSLLKSSEPGLFAVGLHTGEVRTARALLDRDALKQRLVVVVQDHGQPPLSATVT 659

Query: 658 VLIYLSPAL-DAQESMGSV---------NLSLIFIIALGSIAGIL--FVTMIFVAIKCKR 705
           + + ++ ++ D    +GS+          L+L  ++A+ +++ +   FVT + +A+K +R
Sbjct: 660 LTVAVADSIPDVLADLGSLKPSADPDDSGLTLYLVVAVAAVSCVFLAFVT-VLLALKLRR 718

Query: 706 DNK 708
            +K
Sbjct: 719 WHK 721


>gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precursor
           [Homo sapiens]
          Length = 871

 Score =  492 bits (1266), Expect = e-139
 Identities = 285/698 (40%), Positives = 410/698 (58%), Gaps = 28/698 (4%)

Query: 25  LKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVS----NSAPHLVDINPSSGL 80
           ++Y V EE + GT + NVA+D     F LD    SA R+      N     VD++  SG 
Sbjct: 31  IRYPVPEESQEGTFVGNVAQD-----FLLDTDSLSARRLQVAGEVNQRHFRVDLD--SGA 83

Query: 81  LVTKQKIDRDLLCRQSPKCIISLE-VMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEIS 139
           L+ K  IDR+ LC  S  CI+ LE V    +E+   +VEI D+ND+AP FP  Q++LEI 
Sbjct: 84  LLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIG 143

Query: 140 EAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRE 199
           EAA PG R PL+ A D D GS  + +Y L+ NE F L++K R DGS   EL++EK LDRE
Sbjct: 144 EAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLLEKPLDRE 203

Query: 200 TQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIR 259
            QS Y   +TA+DGG+PPR GT  L + V D NDN P F +S+Y +SV E++P    +I+
Sbjct: 204 KQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQ 263

Query: 260 LNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAK 319
           LNASDPD G +G V + F G+  DR R LF + P +G +T+ G LD+E  + YE DV+A+
Sbjct: 264 LNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRAR 323

Query: 320 DLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSG 379
           D G  ++  HC + V +LD NDN P I   +V SEL  + ESA PG V+AL+ V D DSG
Sbjct: 324 DGGSPAMEQHCSLRVDLLDVNDNAPYI---TVTSELGTLPESAEPGTVVALISVQDPDSG 380

Query: 380 LNGRVQCRLLGNVPFRLQE-YESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKS 438
            NG V  R+  ++PF L+  + +  +++  G LDRE    Y++ + A D G P L + ++
Sbjct: 381 SNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRT 440

Query: 439 FTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVR 498
             + I+D NDN P F +  ++V V ENN PG  L S++A DPD GLN  +SY ++  + R
Sbjct: 441 IFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNR 500

Query: 499 DMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVND 558
           D+   +++S+NP +G ++A RSF++EQT+  +F+V A+D G P L S  TVR+ +LD+ND
Sbjct: 501 DVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLND 560

Query: 559 NTPVITAPPLINGT-AEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEG-DRGFFE 616
           N P +  P    G+     +P + G G+L+T V A D D G N  V+Y + E  D   F 
Sbjct: 561 NAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFA 620

Query: 617 IDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLIYLS----PAL-DAQES 671
           + +  GEVRT      +     +L++V  D G   LS S  +L+ L     P + D +ES
Sbjct: 621 VSRYAGEVRTAVPI-PADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRES 679

Query: 672 M----GSVNLSLIFIIALGSIAGILFVTMIFVAIKCKR 705
                G   L+L   ++L +I  + F + + +  KC R
Sbjct: 680 SAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLR 717


>gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precursor
           [Homo sapiens]
          Length = 938

 Score =  492 bits (1266), Expect = e-139
 Identities = 285/698 (40%), Positives = 410/698 (58%), Gaps = 28/698 (4%)

Query: 25  LKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVS----NSAPHLVDINPSSGL 80
           ++Y V EE + GT + NVA+D     F LD    SA R+      N     VD++  SG 
Sbjct: 31  IRYPVPEESQEGTFVGNVAQD-----FLLDTDSLSARRLQVAGEVNQRHFRVDLD--SGA 83

Query: 81  LVTKQKIDRDLLCRQSPKCIISLE-VMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEIS 139
           L+ K  IDR+ LC  S  CI+ LE V    +E+   +VEI D+ND+AP FP  Q++LEI 
Sbjct: 84  LLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIG 143

Query: 140 EAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRE 199
           EAA PG R PL+ A D D GS  + +Y L+ NE F L++K R DGS   EL++EK LDRE
Sbjct: 144 EAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLLEKPLDRE 203

Query: 200 TQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIR 259
            QS Y   +TA+DGG+PPR GT  L + V D NDN P F +S+Y +SV E++P    +I+
Sbjct: 204 KQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQ 263

Query: 260 LNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAK 319
           LNASDPD G +G V + F G+  DR R LF + P +G +T+ G LD+E  + YE DV+A+
Sbjct: 264 LNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRAR 323

Query: 320 DLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSG 379
           D G  ++  HC + V +LD NDN P I   +V SEL  + ESA PG V+AL+ V D DSG
Sbjct: 324 DGGSPAMEQHCSLRVDLLDVNDNAPYI---TVTSELGTLPESAEPGTVVALISVQDPDSG 380

Query: 380 LNGRVQCRLLGNVPFRLQE-YESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKS 438
            NG V  R+  ++PF L+  + +  +++  G LDRE    Y++ + A D G P L + ++
Sbjct: 381 SNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRT 440

Query: 439 FTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVR 498
             + I+D NDN P F +  ++V V ENN PG  L S++A DPD GLN  +SY ++  + R
Sbjct: 441 IFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNR 500

Query: 499 DMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVND 558
           D+   +++S+NP +G ++A RSF++EQT+  +F+V A+D G P L S  TVR+ +LD+ND
Sbjct: 501 DVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLND 560

Query: 559 NTPVITAPPLINGT-AEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEG-DRGFFE 616
           N P +  P    G+     +P + G G+L+T V A D D G N  V+Y + E  D   F 
Sbjct: 561 NAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFA 620

Query: 617 IDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLIYLS----PAL-DAQES 671
           + +  GEVRT      +     +L++V  D G   LS S  +L+ L     P + D +ES
Sbjct: 621 VSRYAGEVRTAVPI-PADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRES 679

Query: 672 M----GSVNLSLIFIIALGSIAGILFVTMIFVAIKCKR 705
                G   L+L   ++L +I  + F + + +  KC R
Sbjct: 680 SAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLR 717


>gi|14165413 protocadherin alpha 4 isoform 2 precursor [Homo
           sapiens]
          Length = 798

 Score =  489 bits (1260), Expect = e-138
 Identities = 283/754 (37%), Positives = 426/754 (56%), Gaps = 36/754 (4%)

Query: 2   ESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAF 61
           ES  L +LLLL   W        L YSV EE + GT +  +A+D       L PR    F
Sbjct: 10  ESRRLLLLLLLLAAWEAGNG--QLHYSVSEEAKHGTFVGRIAQDLGLELAELVPR---LF 64

Query: 62  RVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIK 120
           RV S     L+++N  +G+L    +IDR+ LCR+S +C I LEV+    +++  + VE++
Sbjct: 65  RVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVDVEVR 124

Query: 121 DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT 180
           D+NDN P FPA Q  L I+E+    +R PL+ A D D G   + TY L+PNE F LE   
Sbjct: 125 DINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSLEKPP 184

Query: 181 RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE 240
             +  +   L++ KSLDRE        +TA DGG P   GTV L I V D+NDN P F  
Sbjct: 185 DDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDR 244

Query: 241 STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV 300
           + Y V + EN P  T VI+LNASD DEG NG +VYSF   ++   +  F IDP +G + V
Sbjct: 245 TIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIV 304

Query: 301 TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE 360
            G +D+EE   YE+ V+  D G   +  HC+V V V D NDN P +   S++   + + E
Sbjct: 305 KGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLS---LPIRE 361

Query: 361 SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQY 419
            AP G VIAL+ VSD+D G+NG V C L  +VPF+L   ++++ ++++D  LDRE    Y
Sbjct: 362 DAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSAY 421

Query: 420 NLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARD 479
            L + ARDGG P L +  S +V + D NDN P F++P Y V V+ENN PG ++ +VSA D
Sbjct: 422 ELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWD 481

Query: 480 PDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGG 539
            D   N  VSY +V  +V +  + +YVS++  SG +YAL+  +HE+ +  +F+V A+D G
Sbjct: 482 ADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAG 541

Query: 540 LPSLQSNATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDE 597
           +P L SN T++V +LD NDN P + AP      G     +P + G+G++V  V+A D D 
Sbjct: 542 VPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADS 601

Query: 598 GENGRVTYDMTEGDRGF---FEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSA 654
           G N  ++Y++  G  G    F +    GE+ TTR   E+    + L+V+  DHG+ +L+A
Sbjct: 602 GYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALTA 661

Query: 655 SALVLIYL-----SPALDAQESMGS-------VNLSLIFIIALGSIAGILFVT-MIFVAI 701
           +A VL+ L     +P   ++  +G+       V++++  IIA+ +++ +L +T +++ A+
Sbjct: 662 TATVLVSLVESGQAPKASSRALVGAVGPDAALVDVNVYLIIAICAVSSLLVLTLLLYTAL 721

Query: 702 KCK--------RDNKEIRTYNCRIAEYSYGHQKK 727
           +C            K     +  +  +SY  Q++
Sbjct: 722 RCSALPTEGACAPGKPTLVCSSAVGSWSYSQQRR 755


>gi|9256588 protocadherin alpha 4 isoform 1 precursor [Homo sapiens]
          Length = 947

 Score =  489 bits (1260), Expect = e-138
 Identities = 283/754 (37%), Positives = 426/754 (56%), Gaps = 36/754 (4%)

Query: 2   ESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAF 61
           ES  L +LLLL   W        L YSV EE + GT +  +A+D       L PR    F
Sbjct: 10  ESRRLLLLLLLLAAWEAGNG--QLHYSVSEEAKHGTFVGRIAQDLGLELAELVPR---LF 64

Query: 62  RVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIK 120
           RV S     L+++N  +G+L    +IDR+ LCR+S +C I LEV+    +++  + VE++
Sbjct: 65  RVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVDVEVR 124

Query: 121 DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT 180
           D+NDN P FPA Q  L I+E+    +R PL+ A D D G   + TY L+PNE F LE   
Sbjct: 125 DINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSLEKPP 184

Query: 181 RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE 240
             +  +   L++ KSLDRE        +TA DGG P   GTV L I V D+NDN P F  
Sbjct: 185 DDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDR 244

Query: 241 STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV 300
           + Y V + EN P  T VI+LNASD DEG NG +VYSF   ++   +  F IDP +G + V
Sbjct: 245 TIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIV 304

Query: 301 TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE 360
            G +D+EE   YE+ V+  D G   +  HC+V V V D NDN P +   S++   + + E
Sbjct: 305 KGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLS---LPIRE 361

Query: 361 SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQY 419
            AP G VIAL+ VSD+D G+NG V C L  +VPF+L   ++++ ++++D  LDRE    Y
Sbjct: 362 DAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSAY 421

Query: 420 NLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARD 479
            L + ARDGG P L +  S +V + D NDN P F++P Y V V+ENN PG ++ +VSA D
Sbjct: 422 ELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWD 481

Query: 480 PDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGG 539
            D   N  VSY +V  +V +  + +YVS++  SG +YAL+  +HE+ +  +F+V A+D G
Sbjct: 482 ADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAG 541

Query: 540 LPSLQSNATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDE 597
           +P L SN T++V +LD NDN P + AP      G     +P + G+G++V  V+A D D 
Sbjct: 542 VPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADS 601

Query: 598 GENGRVTYDMTEGDRGF---FEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSA 654
           G N  ++Y++  G  G    F +    GE+ TTR   E+    + L+V+  DHG+ +L+A
Sbjct: 602 GYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALTA 661

Query: 655 SALVLIYL-----SPALDAQESMGS-------VNLSLIFIIALGSIAGILFVT-MIFVAI 701
           +A VL+ L     +P   ++  +G+       V++++  IIA+ +++ +L +T +++ A+
Sbjct: 662 TATVLVSLVESGQAPKASSRALVGAVGPDAALVDVNVYLIIAICAVSSLLVLTLLLYTAL 721

Query: 702 KCK--------RDNKEIRTYNCRIAEYSYGHQKK 727
           +C            K     +  +  +SY  Q++
Sbjct: 722 RCSALPTEGACAPGKPTLVCSSAVGSWSYSQQRR 755


>gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo
           sapiens]
          Length = 814

 Score =  489 bits (1258), Expect = e-138
 Identities = 279/749 (37%), Positives = 433/749 (57%), Gaps = 36/749 (4%)

Query: 6   LPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVS 65
           L +LLLL   W   +    L YSV EE + GT +  +A+D       L PR    FRV S
Sbjct: 14  LLLLLLLLAAWKVGSG--QLHYSVPEEAKHGTFVGRIAQDLGLELAELVPR---LFRVAS 68

Query: 66  NSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIKDLND 124
                L++++  +G+L    +IDR+ LC +S +C I LEV+    +++  + VE+KD+ND
Sbjct: 69  KRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVND 128

Query: 125 NAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDG 184
           N P F     +L +SE+  P +R PL+ A D D G+  V TY L+ ++ F L++ ++ D 
Sbjct: 129 NPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDE 188

Query: 185 SRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYA 244
           ++  ELV+ KSLDRE    +   +TA DGG P   GTV L + V D NDN P F +S Y 
Sbjct: 189 NKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248

Query: 245 VSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGAL 304
           V + EN+   T VI+LNASDPDEG NG + YSF   V     + F ID ++G + + G L
Sbjct: 249 VRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNL 308

Query: 305 DYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPP 364
           D+E+ ++Y++ + A D G   +  HC V V +LD NDN P I L S++   + V E A  
Sbjct: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLS---LPVREDAQF 365

Query: 365 GYVIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQYNLTI 423
           G VIAL+ V+D DSG NG+V C L+ +VPF+L   ++++ ++++D  LDRE+   Y L +
Sbjct: 366 GTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVV 425

Query: 424 QARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLG 483
            ARDGG P L +  S +V + D NDN P F++P Y V V+ENN PG ++ +VSARD D  
Sbjct: 426 TARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQ 485

Query: 484 LNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSL 543
            N  VSY +V  +V +  + +Y+S++  SG +YAL+  +HE+ +  +F+V A+D G+P L
Sbjct: 486 ENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPL 545

Query: 544 QSNATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDEGENG 601
            SN T++V +LD NDN P +  P +    G A   +PR+ G G++V  V+A D D G N 
Sbjct: 546 GSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNA 605

Query: 602 RVTYDM---TEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALV 658
            ++Y++       R  F +    GE+ TTR   E+    + L+V+  DHG+ +L+A+A V
Sbjct: 606 WLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATV 665

Query: 659 LIYL-----SPALDAQESMG-------SVNLSLIFIIALGSIAGILFVT-MIFVAIKCK- 704
           L+ L     +P   +++S G        V++++  IIA+ +++ +L +T +++ A++C  
Sbjct: 666 LVSLVESGQAPKASSRQSAGVLGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSA 725

Query: 705 -------RDNKEIRTYNCRIAEYSYGHQK 726
                  R  K     +  +  +SY  Q+
Sbjct: 726 LPTEGGCRAGKPTLVCSSAVGSWSYSQQQ 754


>gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score =  489 bits (1258), Expect = e-138
 Identities = 279/749 (37%), Positives = 433/749 (57%), Gaps = 36/749 (4%)

Query: 6   LPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVS 65
           L +LLLL   W   +    L YSV EE + GT +  +A+D       L PR    FRV S
Sbjct: 14  LLLLLLLLAAWKVGSG--QLHYSVPEEAKHGTFVGRIAQDLGLELAELVPR---LFRVAS 68

Query: 66  NSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIKDLND 124
                L++++  +G+L    +IDR+ LC +S +C I LEV+    +++  + VE+KD+ND
Sbjct: 69  KRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVND 128

Query: 125 NAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDG 184
           N P F     +L +SE+  P +R PL+ A D D G+  V TY L+ ++ F L++ ++ D 
Sbjct: 129 NPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDE 188

Query: 185 SRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYA 244
           ++  ELV+ KSLDRE    +   +TA DGG P   GTV L + V D NDN P F +S Y 
Sbjct: 189 NKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248

Query: 245 VSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGAL 304
           V + EN+   T VI+LNASDPDEG NG + YSF   V     + F ID ++G + + G L
Sbjct: 249 VRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNL 308

Query: 305 DYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPP 364
           D+E+ ++Y++ + A D G   +  HC V V +LD NDN P I L S++   + V E A  
Sbjct: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLS---LPVREDAQF 365

Query: 365 GYVIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQYNLTI 423
           G VIAL+ V+D DSG NG+V C L+ +VPF+L   ++++ ++++D  LDRE+   Y L +
Sbjct: 366 GTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVV 425

Query: 424 QARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLG 483
            ARDGG P L +  S +V + D NDN P F++P Y V V+ENN PG ++ +VSARD D  
Sbjct: 426 TARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQ 485

Query: 484 LNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSL 543
            N  VSY +V  +V +  + +Y+S++  SG +YAL+  +HE+ +  +F+V A+D G+P L
Sbjct: 486 ENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPL 545

Query: 544 QSNATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDEGENG 601
            SN T++V +LD NDN P +  P +    G A   +PR+ G G++V  V+A D D G N 
Sbjct: 546 GSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNA 605

Query: 602 RVTYDM---TEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALV 658
            ++Y++       R  F +    GE+ TTR   E+    + L+V+  DHG+ +L+A+A V
Sbjct: 606 WLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATV 665

Query: 659 LIYL-----SPALDAQESMG-------SVNLSLIFIIALGSIAGILFVT-MIFVAIKCK- 704
           L+ L     +P   +++S G        V++++  IIA+ +++ +L +T +++ A++C  
Sbjct: 666 LVSLVESGQAPKASSRQSAGVLGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSA 725

Query: 705 -------RDNKEIRTYNCRIAEYSYGHQK 726
                  R  K     +  +  +SY  Q+
Sbjct: 726 LPTEGGCRAGKPTLVCSSAVGSWSYSQQQ 754


>gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo
           sapiens]
          Length = 803

 Score =  488 bits (1255), Expect = e-137
 Identities = 280/754 (37%), Positives = 436/754 (57%), Gaps = 38/754 (5%)

Query: 2   ESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAF 61
           + LLLP+LLL A  W   +    L YSV EE + GT +  +A+D       L PR    F
Sbjct: 12  QCLLLPLLLLAA--WKVGSG--QLHYSVPEEAKHGTFVGRIAQDLGLELAELVPR---LF 64

Query: 62  RVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIK 120
           R+ S     L+++N  +G+L    +IDR+ LC +S +C I LEV+    +++  + VE++
Sbjct: 65  RMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVR 124

Query: 121 DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT 180
           D+NDN P FP  +  + I E+  P +  PL+ A D D GS  + TY+L+ +E FGL++K 
Sbjct: 125 DINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKI 184

Query: 181 RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE 240
             D ++   L+++KSLDRE    ++  +TA DGG P   GTV L + V D NDN P F +
Sbjct: 185 NSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQ 244

Query: 241 STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV 300
           S Y V + EN+   T VIRLNASD DEG NG + YSF   V     + F ID ++G + +
Sbjct: 245 SEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVI 304

Query: 301 TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE 360
            G LD+E+ ++Y++ + A D G   +  HC V V +LD NDN P I L S++   + V E
Sbjct: 305 RGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLS---LPVRE 361

Query: 361 SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQY 419
            A  G VIAL+ V+D DSG NG+V C L  +VPF+L   ++++ ++++D  LDRE    Y
Sbjct: 362 DAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAY 421

Query: 420 NLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARD 479
            L + ARDGG P L +  S +V + D NDN P F++P Y V V+ENN PG ++ +VSARD
Sbjct: 422 ELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARD 481

Query: 480 PDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGG 539
            D   N  VSY +V  +V +  + +Y+S++  SG +YAL+  +HE+ +  +F+V A+D G
Sbjct: 482 ADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQVSARDAG 541

Query: 540 LPSLQSNATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDE 597
           +P L SN T++V +LD NDN P + AP +    G     +PR+ G G +V  V+A D D 
Sbjct: 542 VPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADS 601

Query: 598 GENGRVTYDM---TEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSA 654
           G N  ++Y++       R  F +    GE+ TTR   E+    + L+V+  DHG+ +L+A
Sbjct: 602 GYNAWLSYELQPPASSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTA 661

Query: 655 SALVLIYL-----SPALDAQESMGS-------VNLSLIFIIALGSIAGILFVT-MIFVAI 701
           +A VL+ L     +P   ++ S+G+       V++++  IIA+ +++ +L +T +++ A+
Sbjct: 662 TATVLVSLVESGQAPKASSRASVGAAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTAL 721

Query: 702 KCKRD--------NKEIRTYNCRIAEYSYGHQKK 727
           +C           +K     +  +  +SY  Q++
Sbjct: 722 RCSAPPTEGACTADKPTLVCSSAVGSWSYSQQRR 755


>gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score =  488 bits (1255), Expect = e-137
 Identities = 280/754 (37%), Positives = 436/754 (57%), Gaps = 38/754 (5%)

Query: 2   ESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAF 61
           + LLLP+LLL A  W   +    L YSV EE + GT +  +A+D       L PR    F
Sbjct: 12  QCLLLPLLLLAA--WKVGSG--QLHYSVPEEAKHGTFVGRIAQDLGLELAELVPR---LF 64

Query: 62  RVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIK 120
           R+ S     L+++N  +G+L    +IDR+ LC +S +C I LEV+    +++  + VE++
Sbjct: 65  RMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVR 124

Query: 121 DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT 180
           D+NDN P FP  +  + I E+  P +  PL+ A D D GS  + TY+L+ +E FGL++K 
Sbjct: 125 DINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKI 184

Query: 181 RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE 240
             D ++   L+++KSLDRE    ++  +TA DGG P   GTV L + V D NDN P F +
Sbjct: 185 NSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQ 244

Query: 241 STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV 300
           S Y V + EN+   T VIRLNASD DEG NG + YSF   V     + F ID ++G + +
Sbjct: 245 SEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVI 304

Query: 301 TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE 360
            G LD+E+ ++Y++ + A D G   +  HC V V +LD NDN P I L S++   + V E
Sbjct: 305 RGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLS---LPVRE 361

Query: 361 SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQY 419
            A  G VIAL+ V+D DSG NG+V C L  +VPF+L   ++++ ++++D  LDRE    Y
Sbjct: 362 DAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAY 421

Query: 420 NLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARD 479
            L + ARDGG P L +  S +V + D NDN P F++P Y V V+ENN PG ++ +VSARD
Sbjct: 422 ELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARD 481

Query: 480 PDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGG 539
            D   N  VSY +V  +V +  + +Y+S++  SG +YAL+  +HE+ +  +F+V A+D G
Sbjct: 482 ADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQVSARDAG 541

Query: 540 LPSLQSNATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDE 597
           +P L SN T++V +LD NDN P + AP +    G     +PR+ G G +V  V+A D D 
Sbjct: 542 VPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADS 601

Query: 598 GENGRVTYDM---TEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSA 654
           G N  ++Y++       R  F +    GE+ TTR   E+    + L+V+  DHG+ +L+A
Sbjct: 602 GYNAWLSYELQPPASSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTA 661

Query: 655 SALVLIYL-----SPALDAQESMGS-------VNLSLIFIIALGSIAGILFVT-MIFVAI 701
           +A VL+ L     +P   ++ S+G+       V++++  IIA+ +++ +L +T +++ A+
Sbjct: 662 TATVLVSLVESGQAPKASSRASVGAAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTAL 721

Query: 702 KCKRD--------NKEIRTYNCRIAEYSYGHQKK 727
           +C           +K     +  +  +SY  Q++
Sbjct: 722 RCSAPPTEGACTADKPTLVCSSAVGSWSYSQQRR 755


>gi|14165419 protocadherin alpha 7 isoform 2 precursor [Homo
           sapiens]
          Length = 789

 Score =  486 bits (1250), Expect = e-137
 Identities = 277/722 (38%), Positives = 414/722 (57%), Gaps = 26/722 (3%)

Query: 8   VLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67
           +LL + IL    A    L YSV EE + G  +  +A+D       L PR    FR V   
Sbjct: 14  LLLFIIILAAWEAGRGQLHYSVPEEAKHGNFVGRIAQDLGLELAELVPR---LFRAVCKF 70

Query: 68  APHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIKDLNDNA 126
              L+++N  +G+L    +IDR+ LC +S +C I LEV+    +++  + VE+KD+NDN 
Sbjct: 71  RGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDNP 130

Query: 127 PSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSR 186
           P FPA Q  L I+E+    +R PL+ A D D G   + TY L+PNE F L++ T     +
Sbjct: 131 PVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVK 190

Query: 187 FAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVS 246
              LV+ K LDRE        +TA DGG P   GTV L I V D+NDN PVF  + Y V 
Sbjct: 191 PLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVK 250

Query: 247 VPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDY 306
           +PEN    T VI  NASD DEG NG ++YSF   V+   +  F +DP SG +TV G +D+
Sbjct: 251 LPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDF 310

Query: 307 EEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGY 366
           EE   +++ V+A D G   +  HC V V V+D NDN P + L S++   + + E A PG 
Sbjct: 311 EESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLS---LPIPEDAQPGT 367

Query: 367 VIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQYNLTIQA 425
           VI L+ V DRD G+NG+V C L   VPF+L   ++++ ++++D  LDRE    Y L + A
Sbjct: 368 VITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTA 427

Query: 426 RDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLN 485
           RDGG P L +  S +V + D NDN P F++P Y V V+ENN PG ++ +VSA D D   N
Sbjct: 428 RDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKN 487

Query: 486 GSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQS 545
             VSY +V  +V +  + +YVS++  SG +YAL+  +HE+ +  +F+V A+D G+P L S
Sbjct: 488 ALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGS 547

Query: 546 NATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRV 603
           N T++V +LD NDN P + AP +    G     +PR+ G G++V  V+A D D G N  +
Sbjct: 548 NVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWL 607

Query: 604 TYDMTEGDRGF---FEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI 660
           +Y++     G    F +    GE+ TTR   E+    + L+V+  DHG+ SL+A+A VL+
Sbjct: 608 SYELQPVAAGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPSLTATATVLV 667

Query: 661 YL-----SPALDAQESMG-------SVNLSLIFIIALGSIAGILFVT-MIFVAIKCKRDN 707
            L     +P   ++ S+G        V++++  IIA+ +++ +L +T +++ A++C   +
Sbjct: 668 SLVESGQAPKASSRASLGIAGPETELVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPS 727

Query: 708 KE 709
            E
Sbjct: 728 SE 729


>gi|9256594 protocadherin alpha 7 isoform 1 precursor [Homo sapiens]
          Length = 937

 Score =  486 bits (1250), Expect = e-137
 Identities = 277/722 (38%), Positives = 414/722 (57%), Gaps = 26/722 (3%)

Query: 8   VLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67
           +LL + IL    A    L YSV EE + G  +  +A+D       L PR    FR V   
Sbjct: 14  LLLFIIILAAWEAGRGQLHYSVPEEAKHGNFVGRIAQDLGLELAELVPR---LFRAVCKF 70

Query: 68  APHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIKDLNDNA 126
              L+++N  +G+L    +IDR+ LC +S +C I LEV+    +++  + VE+KD+NDN 
Sbjct: 71  RGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDNP 130

Query: 127 PSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSR 186
           P FPA Q  L I+E+    +R PL+ A D D G   + TY L+PNE F L++ T     +
Sbjct: 131 PVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVK 190

Query: 187 FAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVS 246
              LV+ K LDRE        +TA DGG P   GTV L I V D+NDN PVF  + Y V 
Sbjct: 191 PLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVK 250

Query: 247 VPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDY 306
           +PEN    T VI  NASD DEG NG ++YSF   V+   +  F +DP SG +TV G +D+
Sbjct: 251 LPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDF 310

Query: 307 EEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGY 366
           EE   +++ V+A D G   +  HC V V V+D NDN P + L S++   + + E A PG 
Sbjct: 311 EESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLS---LPIPEDAQPGT 367

Query: 367 VIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQYNLTIQA 425
           VI L+ V DRD G+NG+V C L   VPF+L   ++++ ++++D  LDRE    Y L + A
Sbjct: 368 VITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTA 427

Query: 426 RDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLN 485
           RDGG P L +  S +V + D NDN P F++P Y V V+ENN PG ++ +VSA D D   N
Sbjct: 428 RDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKN 487

Query: 486 GSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQS 545
             VSY +V  +V +  + +YVS++  SG +YAL+  +HE+ +  +F+V A+D G+P L S
Sbjct: 488 ALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGS 547

Query: 546 NATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRV 603
           N T++V +LD NDN P + AP +    G     +PR+ G G++V  V+A D D G N  +
Sbjct: 548 NVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWL 607

Query: 604 TYDMTEGDRGF---FEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI 660
           +Y++     G    F +    GE+ TTR   E+    + L+V+  DHG+ SL+A+A VL+
Sbjct: 608 SYELQPVAAGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPSLTATATVLV 667

Query: 661 YL-----SPALDAQESMG-------SVNLSLIFIIALGSIAGILFVT-MIFVAIKCKRDN 707
            L     +P   ++ S+G        V++++  IIA+ +++ +L +T +++ A++C   +
Sbjct: 668 SLVESGQAPKASSRASLGIAGPETELVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPS 727

Query: 708 KE 709
            E
Sbjct: 728 SE 729


>gi|11128035 protocadherin gamma subfamily B, 2 isoform 1 precursor
           [Homo sapiens]
          Length = 931

 Score =  486 bits (1250), Expect = e-137
 Identities = 272/708 (38%), Positives = 412/708 (58%), Gaps = 29/708 (4%)

Query: 4   LLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRV 63
           +LLP LL L       A  + ++YS+ EE    +V+ N+AKD       L  R   A ++
Sbjct: 16  VLLPFLLSLF----PGALPVQIRYSIPEELAKNSVVGNLAKD-----LGLSVRDLPARKL 66

Query: 64  VSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSS-MEICVIKVEIKDL 122
             ++      +NP SG L+   +IDR+ +C + P C++  + ++ + + I  I V ++D+
Sbjct: 67  RVSAEKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDI 126

Query: 123 NDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRG 182
           NDN P F   +I L+I E+  PGT  PLD A D D G   +Q Y L  NE F L  K   
Sbjct: 127 NDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTP 186

Query: 183 DGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSEST 242
           DG ++ EL+++ SLDRE  S +   +TA+DGGDPP+ GT  + IKVTD+NDN PVFS+  
Sbjct: 187 DGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDV 246

Query: 243 YAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTG 302
           Y V++ E+ PP   V+++ A+D DEG N ++ YSF+  V+++ +  F ++  +G +T   
Sbjct: 247 YRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHN-VDEQVKHFFNLNEKTGEITTKD 305

Query: 303 ALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESA 362
            LD+E    Y L ++AKD  P  + AHC + V +LD ND  P + + SV++ L    E +
Sbjct: 306 DLDFEIASSYTLSIEAKD--PGDLAAHCSIQVEILDDNDCAPEVIVTSVSTPL---PEDS 360

Query: 363 PPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQ-EYESFSTILVDGRLDREQHDQYNL 421
           PPG VIAL++  DRDSG NG V C++LGN  F L+   +++  ++ DG LDRE+  +YNL
Sbjct: 361 PPGTVIALIKTRDRDSGENGEVYCQVLGNAKFILKSSSKNYYKLVTDGALDREEIPEYNL 420

Query: 422 TIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPD 481
           TI A DGG P L S+   T+ I+D NDN P F +  Y V V ENN PGA +  +SA DPD
Sbjct: 421 TITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPD 480

Query: 482 LGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLP 541
           LG +G VSY IV S ++   + +YVS++  SG ++A R+F+HEQ +AFE  + A+D G P
Sbjct: 481 LGPSGQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSP 540

Query: 542 SLQSNATVRVIILDVNDNTPVITAPPLINGTAEVY--IPRNSGIGYLVTVVKAEDYDEGE 599
           +L +N ++RV++ D+NDN P +  P L    + ++  +PR +  GYLVT V A D D G 
Sbjct: 541 ALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGH 600

Query: 600 NGRVTYDMTE-GDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALV 658
           N  ++Y + +  + G F +    GEVRT R  G+   +   L+V   D G+  LSA+A +
Sbjct: 601 NAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATL 660

Query: 659 LIYLSPALD---------AQESMGSVNLSLIFIIALGSIAGILFVTMI 697
            +  + +L           + S     L    ++AL  I+ + F+ +I
Sbjct: 661 HLIFADSLQEVLPDLSDRREPSDPQAKLQFYLVVALALISVLFFLAVI 708


>gi|14270493 protocadherin gamma subfamily B, 2 isoform 2 precursor
           [Homo sapiens]
          Length = 811

 Score =  486 bits (1250), Expect = e-137
 Identities = 272/708 (38%), Positives = 412/708 (58%), Gaps = 29/708 (4%)

Query: 4   LLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRV 63
           +LLP LL L       A  + ++YS+ EE    +V+ N+AKD       L  R   A ++
Sbjct: 16  VLLPFLLSLF----PGALPVQIRYSIPEELAKNSVVGNLAKD-----LGLSVRDLPARKL 66

Query: 64  VSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSS-MEICVIKVEIKDL 122
             ++      +NP SG L+   +IDR+ +C + P C++  + ++ + + I  I V ++D+
Sbjct: 67  RVSAEKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDI 126

Query: 123 NDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRG 182
           NDN P F   +I L+I E+  PGT  PLD A D D G   +Q Y L  NE F L  K   
Sbjct: 127 NDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTP 186

Query: 183 DGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSEST 242
           DG ++ EL+++ SLDRE  S +   +TA+DGGDPP+ GT  + IKVTD+NDN PVFS+  
Sbjct: 187 DGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDV 246

Query: 243 YAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTG 302
           Y V++ E+ PP   V+++ A+D DEG N ++ YSF+  V+++ +  F ++  +G +T   
Sbjct: 247 YRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHN-VDEQVKHFFNLNEKTGEITTKD 305

Query: 303 ALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESA 362
            LD+E    Y L ++AKD  P  + AHC + V +LD ND  P + + SV++ L    E +
Sbjct: 306 DLDFEIASSYTLSIEAKD--PGDLAAHCSIQVEILDDNDCAPEVIVTSVSTPL---PEDS 360

Query: 363 PPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQ-EYESFSTILVDGRLDREQHDQYNL 421
           PPG VIAL++  DRDSG NG V C++LGN  F L+   +++  ++ DG LDRE+  +YNL
Sbjct: 361 PPGTVIALIKTRDRDSGENGEVYCQVLGNAKFILKSSSKNYYKLVTDGALDREEIPEYNL 420

Query: 422 TIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPD 481
           TI A DGG P L S+   T+ I+D NDN P F +  Y V V ENN PGA +  +SA DPD
Sbjct: 421 TITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPD 480

Query: 482 LGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLP 541
           LG +G VSY IV S ++   + +YVS++  SG ++A R+F+HEQ +AFE  + A+D G P
Sbjct: 481 LGPSGQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSP 540

Query: 542 SLQSNATVRVIILDVNDNTPVITAPPLINGTAEVY--IPRNSGIGYLVTVVKAEDYDEGE 599
           +L +N ++RV++ D+NDN P +  P L    + ++  +PR +  GYLVT V A D D G 
Sbjct: 541 ALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGH 600

Query: 600 NGRVTYDMTE-GDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALV 658
           N  ++Y + +  + G F +    GEVRT R  G+   +   L+V   D G+  LSA+A +
Sbjct: 601 NAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATL 660

Query: 659 LIYLSPALD---------AQESMGSVNLSLIFIIALGSIAGILFVTMI 697
            +  + +L           + S     L    ++AL  I+ + F+ +I
Sbjct: 661 HLIFADSLQEVLPDLSDRREPSDPQAKLQFYLVVALALISVLFFLAVI 708


>gi|7706113 protocadherin 12 precursor [Homo sapiens]
          Length = 1184

 Score =  485 bits (1249), Expect = e-137
 Identities = 293/768 (38%), Positives = 436/768 (56%), Gaps = 55/768 (7%)

Query: 18  QAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQA-SAFRVVSNSAPHLVDINP 76
           Q    + +KY V EE  +GTVI  +++   E G     RQA +AF+V+       + ++ 
Sbjct: 25  QEVTTLTVKYQVSEEVPSGTVIGKLSQ---ELGREERRRQAGAAFQVLQLPQALPIQVDS 81

Query: 77  SSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIK--DLNDNAPSFPAAQI 134
             GLL T +++DR+ LCRQ   C++S +V+++  ++ +I VEI+  D+ND+ P FP  + 
Sbjct: 82  EEGLLSTGRRLDREQLCRQWDPCLVSFDVLATG-DLALIHVEIQVLDINDHQPRFPKGEQ 140

Query: 135 ELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEK 194
           ELEISE+AS  TRIPLD A DPD+G   + TY L+P+E F L++    D ++ AEL+V K
Sbjct: 141 ELEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELIVVK 200

Query: 195 SLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPN 254
            LDRE  S +   +TA D G+PP+ GT  + + V DSNDN+P F+ES+ A+ + E++ P 
Sbjct: 201 ELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPG 260

Query: 255 TPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYEL 314
           T +I+L A+DPD+G NG+V +    ++     + F ID  +G V +   LDYE+   YE+
Sbjct: 261 TLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLDYEKNPAYEV 320

Query: 315 DVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVS 374
           DVQA+DLGPN IPAHCKV + VLD NDN P I++   +   + VSE+ P    IALV   
Sbjct: 321 DVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSL-VSEALPKDSFIALVMAD 379

Query: 375 DRDSGLNGRVQCRL---LGNVPFRLQEYESFS-TILVDGRLDREQHDQYNLTIQARDGGV 430
           D DSG NG V C L   LG+  FRL+     +  +L +  LDREQ  +Y LT+ A+D G+
Sbjct: 380 DLDSGHNGLVHCWLSQELGH--FRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQGL 437

Query: 431 PMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSY 490
             L + K  ++ I+D NDN P F K  Y+V  +ENN P  +L+++ A D DLG+NG VSY
Sbjct: 438 QPLSAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSLHLITIKAHDADLGINGKVSY 497

Query: 491 QIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVR 550
           +I     +D PV   V+I+ N+G++ A RS N+E+   FEF+V+A+D G P L S+ +V 
Sbjct: 498 RI-----QDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSVW 552

Query: 551 VIILDVNDNTPVITAPPLINGTAEVYIPRNSGIG-------------------------- 584
           V +LD NDN P +  P L +G A + +  N+  G                          
Sbjct: 553 VSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLGPAGTDTPPLATHS 612

Query: 585 ---YLVTVVKAEDYDEGENGRVTYDMTEGDRG-FFEIDQVNGEVRTTRTFGESS-KSSYE 639
              +L+T + A D D G NG   Y +  G+    F ++   G++    T   S   S +E
Sbjct: 613 SRPFLLTTIVARDADSGANGEPLYSIRSGNEAHLFILNPHTGQLFVNVTNASSLIGSEWE 672

Query: 640 LIVVAHDHGKTSLSASALVLIYLSPALD----AQESMGSVNLSLIFIIALGSIAGILFVT 695
           L +V  D G   L   AL+ +    ++D    +    G++++S++ +I L  + GI  + 
Sbjct: 673 LEIVVEDQGSPPLQTRALLRVMFVTSVDHLRDSARKPGALSMSMLTVICLAVLLGIFGLI 732

Query: 696 MIFVAIKCKRDNKEIRTYNCRIAEYSYGHQKKSSKKKKISKNDIRLVP 743
           +      C+ + K+ R YNCR AE +Y  Q K   +K I K DI LVP
Sbjct: 733 LALFMSICRTEKKDNRAYNCREAESTYRQQPK-RPQKHIQKADIHLVP 779


>gi|14165387 protocadherin alpha 11 isoform 2 precursor [Homo
           sapiens]
          Length = 810

 Score =  483 bits (1243), Expect = e-136
 Identities = 274/711 (38%), Positives = 413/711 (58%), Gaps = 28/711 (3%)

Query: 6   LPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVS 65
           L + LLL   W   +    L YSV EE + GT +  +A+D    G  L       FRV S
Sbjct: 14  LQLWLLLLEFWEVGSG--QLHYSVSEEAKHGTFVGRIAQDL---GLELAELVQRLFRVAS 68

Query: 66  NSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIKDLND 124
            +   L+++N  +G+L    +IDR+ LC QS +C I LEV+    +++  + VE+KD+ND
Sbjct: 69  KTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVKDIND 128

Query: 125 NAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDG 184
           N P F   + +L I+E+    +R PL+ A D D     + TY L+ NE F L+  T G  
Sbjct: 129 NPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSLDSPTNGKQ 188

Query: 185 SRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYA 244
            +   L+++KSLDRE     +  +TA DGG P   GTV L ++V D NDN+P F +S Y 
Sbjct: 189 IKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKSEYK 248

Query: 245 VSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGAL 304
           VS+ EN+   T V++LNA+D DEG NG+V YS    +    R LF +D ++G V V G L
Sbjct: 249 VSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNNGEVRVNGTL 307

Query: 305 DYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPP 364
           DYEE   Y+++VQA D G   +  HC V V +LDTNDN P + + S++   + V E A P
Sbjct: 308 DYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLS---LPVREDAQP 364

Query: 365 GYVIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQYNLTI 423
             VIAL+ VSDRDSG+NG+V C L  +VPF+L   ++++ ++++D  LDRE    Y L +
Sbjct: 365 STVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAYELVV 424

Query: 424 QARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLG 483
            ARDGG P L +    +V + D NDN P F++P Y V V+ENN PG ++ +VSARD D  
Sbjct: 425 TARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQ 484

Query: 484 LNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSL 543
            N  VSY +V  ++ D  + +YVS++  SG +YAL+  +HE+ +  +F+V A+D G+P L
Sbjct: 485 ENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPL 544

Query: 544 QSNATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDEGENG 601
            SN T++V +LD NDN P + A       G     +PR+ G G++V  V+A D D G N 
Sbjct: 545 SSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDADSGYNA 604

Query: 602 RVTYDM---TEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALV 658
            ++Y++     G R  F +    GE+ TTR   E+    + L+V+  DHG+ +L+A+A V
Sbjct: 605 WLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTATATV 664

Query: 659 LIYL-----SPALDAQESMGS-------VNLSLIFIIALGSIAGILFVTMI 697
           L+ L     +P   ++   G+       V++++  IIA+  ++ +L +T++
Sbjct: 665 LVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLL 715


>gi|9256576 protocadherin alpha 11 isoform 1 precursor [Homo
           sapiens]
          Length = 949

 Score =  483 bits (1243), Expect = e-136
 Identities = 274/711 (38%), Positives = 413/711 (58%), Gaps = 28/711 (3%)

Query: 6   LPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVS 65
           L + LLL   W   +    L YSV EE + GT +  +A+D    G  L       FRV S
Sbjct: 14  LQLWLLLLEFWEVGSG--QLHYSVSEEAKHGTFVGRIAQDL---GLELAELVQRLFRVAS 68

Query: 66  NSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIKDLND 124
            +   L+++N  +G+L    +IDR+ LC QS +C I LEV+    +++  + VE+KD+ND
Sbjct: 69  KTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVKDIND 128

Query: 125 NAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDG 184
           N P F   + +L I+E+    +R PL+ A D D     + TY L+ NE F L+  T G  
Sbjct: 129 NPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSLDSPTNGKQ 188

Query: 185 SRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYA 244
            +   L+++KSLDRE     +  +TA DGG P   GTV L ++V D NDN+P F +S Y 
Sbjct: 189 IKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKSEYK 248

Query: 245 VSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGAL 304
           VS+ EN+   T V++LNA+D DEG NG+V YS    +    R LF +D ++G V V G L
Sbjct: 249 VSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNNGEVRVNGTL 307

Query: 305 DYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPP 364
           DYEE   Y+++VQA D G   +  HC V V +LDTNDN P + + S++   + V E A P
Sbjct: 308 DYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLS---LPVREDAQP 364

Query: 365 GYVIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQYNLTI 423
             VIAL+ VSDRDSG+NG+V C L  +VPF+L   ++++ ++++D  LDRE    Y L +
Sbjct: 365 STVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAYELVV 424

Query: 424 QARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLG 483
            ARDGG P L +    +V + D NDN P F++P Y V V+ENN PG ++ +VSARD D  
Sbjct: 425 TARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQ 484

Query: 484 LNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSL 543
            N  VSY +V  ++ D  + +YVS++  SG +YAL+  +HE+ +  +F+V A+D G+P L
Sbjct: 485 ENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPL 544

Query: 544 QSNATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDEGENG 601
            SN T++V +LD NDN P + A       G     +PR+ G G++V  V+A D D G N 
Sbjct: 545 SSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDADSGYNA 604

Query: 602 RVTYDM---TEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALV 658
            ++Y++     G R  F +    GE+ TTR   E+    + L+V+  DHG+ +L+A+A V
Sbjct: 605 WLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTATATV 664

Query: 659 LIYL-----SPALDAQESMGS-------VNLSLIFIIALGSIAGILFVTMI 697
           L+ L     +P   ++   G+       V++++  IIA+  ++ +L +T++
Sbjct: 665 LVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLL 715


>gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo
           sapiens]
          Length = 807

 Score =  483 bits (1243), Expect = e-136
 Identities = 276/716 (38%), Positives = 418/716 (58%), Gaps = 26/716 (3%)

Query: 8   VLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67
           +LL L IL         L YSV EE + GT +  +A+D       L PR    FRV S  
Sbjct: 14  LLLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPR---LFRVASKR 70

Query: 68  APHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIKDLNDNA 126
              L+++N  +G+L    +IDR+ LC +S +C I LEV+    +++  ++V+++D+NDN 
Sbjct: 71  HGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNP 130

Query: 127 PSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSR 186
           P FP ++  + I+E+  P TR PLD A D D G     TY L PN+ F L+ +   +   
Sbjct: 131 PIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMS 190

Query: 187 FAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVS 246
              LV+ K+LDRE    +S  +TA DGG P   GTV L I + D NDN P F +S Y V+
Sbjct: 191 SLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVT 250

Query: 247 VPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDY 306
           V EN+   T VI+LNA+DPD+GTNG +VYSF   V       F I+P++G +   G LD+
Sbjct: 251 VLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDF 310

Query: 307 EEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGY 366
           EE  +YE+ V+A D G   +  HC + V VLD NDN P + + S++   + + E   P  
Sbjct: 311 EEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLS---LPIREDTQPSA 367

Query: 367 VIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQYNLTIQA 425
           +IAL+ VSDRDSG NG+V C L  +VPF+L   Y+++ ++++D  LDRE    Y L + A
Sbjct: 368 IIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTA 427

Query: 426 RDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLN 485
           RDGG P L +  S +V + D NDN P F++P Y V V+ENN PG ++ +VSA+D D   N
Sbjct: 428 RDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQEN 487

Query: 486 GSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQS 545
             VSY +V  +V +  + +YVS++  SG +YAL+  +HE+ +  +F+V A+D G+P L S
Sbjct: 488 ALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGS 547

Query: 546 NATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRV 603
           N T++V +LD NDN P +  P      GT    +PR+ G G++V  V+A D D G N  +
Sbjct: 548 NVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWL 607

Query: 604 TYDM---TEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI 660
           +Y++     G R  F +    GE+ TTR   E     + L+V+  DHG+ +L+A+A VL+
Sbjct: 608 SYELQLAAVGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLL 667

Query: 661 YL-----SPALDAQESMGS-------VNLSLIFIIALGSIAGILFVT-MIFVAIKC 703
            L     +P   ++ S G+       V++++  IIA+ +++ +L +T +++ A++C
Sbjct: 668 SLVESGQAPQASSRASAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRC 723


>gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo
           sapiens]
          Length = 950

 Score =  483 bits (1243), Expect = e-136
 Identities = 276/716 (38%), Positives = 418/716 (58%), Gaps = 26/716 (3%)

Query: 8   VLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67
           +LL L IL         L YSV EE + GT +  +A+D       L PR    FRV S  
Sbjct: 14  LLLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPR---LFRVASKR 70

Query: 68  APHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVM-SSSMEICVIKVEIKDLNDNA 126
              L+++N  +G+L    +IDR+ LC +S +C I LEV+    +++  ++V+++D+NDN 
Sbjct: 71  HGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNP 130

Query: 127 PSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSR 186
           P FP ++  + I+E+  P TR PLD A D D G     TY L PN+ F L+ +   +   
Sbjct: 131 PIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMS 190

Query: 187 FAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVS 246
              LV+ K+LDRE    +S  +TA DGG P   GTV L I + D NDN P F +S Y V+
Sbjct: 191 SLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVT 250

Query: 247 VPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDY 306
           V EN+   T VI+LNA+DPD+GTNG +VYSF   V       F I+P++G +   G LD+
Sbjct: 251 VLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDF 310

Query: 307 EEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGY 366
           EE  +YE+ V+A D G   +  HC + V VLD NDN P + + S++   + + E   P  
Sbjct: 311 EEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLS---LPIREDTQPSA 367

Query: 367 VIALVRVSDRDSGLNGRVQCRLLGNVPFRL-QEYESFSTILVDGRLDREQHDQYNLTIQA 425
           +IAL+ VSDRDSG NG+V C L  +VPF+L   Y+++ ++++D  LDRE    Y L + A
Sbjct: 368 IIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTA 427

Query: 426 RDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLN 485
           RDGG P L +  S +V + D NDN P F++P Y V V+ENN PG ++ +VSA+D D   N
Sbjct: 428 RDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQEN 487

Query: 486 GSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQS 545
             VSY +V  +V +  + +YVS++  SG +YAL+  +HE+ +  +F+V A+D G+P L S
Sbjct: 488 ALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGS 547

Query: 546 NATVRVIILDVNDNTPVITAPPL--INGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRV 603
           N T++V +LD NDN P +  P      GT    +PR+ G G++V  V+A D D G N  +
Sbjct: 548 NVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWL 607

Query: 604 TYDM---TEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI 660
           +Y++     G R  F +    GE+ TTR   E     + L+V+  DHG+ +L+A+A VL+
Sbjct: 608 SYELQLAAVGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLL 667

Query: 661 YL-----SPALDAQESMGS-------VNLSLIFIIALGSIAGILFVT-MIFVAIKC 703
            L     +P   ++ S G+       V++++  IIA+ +++ +L +T +++ A++C
Sbjct: 668 SLVESGQAPQASSRASAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRC 723


>gi|14277685 protocadherin gamma subfamily C, 5 isoform 2 precursor
           [Homo sapiens]
          Length = 878

 Score =  481 bits (1238), Expect = e-135
 Identities = 271/699 (38%), Positives = 399/699 (57%), Gaps = 21/699 (3%)

Query: 25  LKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTK 84
           L+YSV EE   GT++ NVA+D    G  +    +   ++ S        ++  SG L   
Sbjct: 31  LRYSVVEESEPGTLVGNVAQDL---GLKMTDLLSRRLQLGSEENGRYFSLSLMSGALAVN 87

Query: 85  QKIDRDLLCRQSPKCIISLEVMSSS-MEICVIKVEIKDLNDNAPSFPAAQIELEISEAAS 143
           QKIDR+ LC  S  C++ ++V++   +E+  ++VEI DLNDN+PSF   + E+ ISE+A+
Sbjct: 88  QKIDRESLCGASTSCLLPVQVVTEHPLELIRVEVEILDLNDNSPSFATPEREMRISESAA 147

Query: 144 PGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSH 203
            G R PLDSA DPD G+  V  Y L+PN  F L +KT  DG  F ELV+E+ LDRE Q+ 
Sbjct: 148 SGARFPLDSAQDPDVGTNTVSFYTLSPNSHFSLNVKTLKDGKPFPELVLEQQLDREAQAR 207

Query: 204 YSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNAS 263
           +   +TA+DGG P R GT  +S+ V D NDN P F  S   V +PEN+P  T ++RLNA+
Sbjct: 208 HQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPIGTLLLRLNAT 267

Query: 264 DPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGP 323
           DPDEGTNGQ+ YSF  + ++  R LF +DP SG + V G +D+EE   YE+  +A+D G 
Sbjct: 268 DPDEGTNGQLDYSFGDHTSEAVRNLFGLDPSSGAIHVLGPIDFEESRFYEIHARARDQGQ 327

Query: 324 NSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGR 383
            ++  HC + V V D NDN P + L S+ +    V ES P G V+ L  V DRDSG NG 
Sbjct: 328 PAMEGHCVIQVDVGDVNDNAPEVLLASLAN---PVLESTPVGTVVGLFNVRDRDSGRNGE 384

Query: 384 VQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLI 443
           V   +  ++PF+++  E+  ++L    LDRE    Y + + A D G P L    +  + I
Sbjct: 385 VSLDISPDLPFQIKPSENHYSLLTSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNI 444

Query: 444 TDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVF 503
           +D NDN P F++  Y   + EN  PG+ L +V+A DPD G N  ++Y IV +QV+  P  
Sbjct: 445 SDVNDNAPRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPAS 504

Query: 504 TYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVI 563
           ++V +NP  G I+A R+F++E  +  +  V  +D G P L +N ++ V +LD NDN P +
Sbjct: 505 SFVYVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPLHANTSLHVFVLDENDNAPAV 564

Query: 564 TAP-PLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGDR--GFFEIDQV 620
             P P    +A   +PR++  G LVT V A D D G N  ++Y +       G F +   
Sbjct: 565 LHPRPDWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSTH 624

Query: 621 NGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLIYLSPALDAQESMGS------ 674
            GEVRT R   E    + +++V+  D+G  SLS++A VL+ L    D +E   S      
Sbjct: 625 TGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDE-DPEEMPKSSDFLIH 683

Query: 675 ----VNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKE 709
                +L+L  I+AL +++ +  VT  F++ KC + N +
Sbjct: 684 PPERSDLTLYLIVALATVSLLSLVTFTFLSAKCLQGNAD 722


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,379,428
Number of Sequences: 37866
Number of extensions: 1964878
Number of successful extensions: 11835
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 3820
Number of HSP's gapped (non-prelim): 750
length of query: 1101
length of database: 18,247,518
effective HSP length: 113
effective length of query: 988
effective length of database: 13,968,660
effective search space: 13801036080
effective search space used: 13801036080
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.