Guide to the Human Genome
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Search of human proteins with 157266266

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157266266 WD repeat domain 86 [Homo sapiens]
         (376 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157266266 WD repeat domain 86 [Homo sapiens]                       783   0.0  
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   162   4e-40
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   162   4e-40
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   162   4e-40
gi|32189425 WD repeat domain 69 [Homo sapiens]                        152   4e-37
gi|113865883 WD repeat domain 38 [Homo sapiens]                       142   4e-34
gi|11968023 zinc finger protein 106 homolog [Homo sapiens]            126   4e-29
gi|4502477 beta-transducin repeat containing protein isoform 2 [...   122   4e-28
gi|16117783 beta-transducin repeat containing protein isoform 1 ...   122   4e-28
gi|48928050 F-box and WD repeat domain containing 11 isoform C [...   120   2e-27
gi|48928048 F-box and WD repeat domain containing 11 isoform A [...   120   2e-27
gi|48928046 F-box and WD repeat domain containing 11 isoform B [...   120   2e-27
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   115   5e-26
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]           115   5e-26
gi|23199987 WD repeat domain 5B [Homo sapiens]                        114   1e-25
gi|16554629 WD repeat domain 5 [Homo sapiens]                         110   2e-24
gi|16554627 WD repeat domain 5 [Homo sapiens]                         110   2e-24
gi|21071067 TBP-associated factor 5 [Homo sapiens]                    110   2e-24
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]           108   1e-23
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [...   103   3e-22
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     97   2e-20
gi|18874090 WD repeat domain 48 [Homo sapiens]                         96   7e-20
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     95   9e-20
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H...    95   1e-19
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ...    93   3e-19
gi|34996489 pleckstrin homology domain interacting protein [Homo...    90   4e-18
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...    88   1e-17
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    88   1e-17
gi|21536371 telomerase-associated protein 1 [Homo sapiens]             87   2e-17
gi|19913369 transducin beta-like 3 [Homo sapiens]                      87   2e-17

>gi|157266266 WD repeat domain 86 [Homo sapiens]
          Length = 376

 Score =  783 bits (2021), Expect = 0.0
 Identities = 376/376 (100%), Positives = 376/376 (100%)

Query: 1   MGGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV 60
           MGGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV
Sbjct: 1   MGGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV 60

Query: 61  TFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTAR 120
           TFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTAR
Sbjct: 61  TFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTAR 120

Query: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV 180
           VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV
Sbjct: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV 180

Query: 181 ASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVIC 240
           ASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVIC
Sbjct: 181 ASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVIC 240

Query: 241 LELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAF 300
           LELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAF
Sbjct: 241 LELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAF 300

Query: 301 DAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSR 360
           DAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSR
Sbjct: 301 DAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSR 360

Query: 361 LFSNKVGCAAAPLQPA 376
           LFSNKVGCAAAPLQPA
Sbjct: 361 LFSNKVGCAAAPLQPA 376


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  162 bits (411), Expect = 4e-40
 Identities = 91/286 (31%), Positives = 141/286 (49%), Gaps = 21/286 (7%)

Query: 27  GQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLT 86
           G R+++GS+D T ++WS   G+C   L GH   V   Q+ D    + S D T++ W+  T
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAET 332

Query: 87  GQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYS 146
           G+C+    GHTS V  + +   ++ S S D T RVW ++ GQ      GH   V  + Y 
Sbjct: 333 GECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 392

Query: 147 APWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGH 206
                           G  +V+G+ D   KVW   +  C  TL+GHT  V  L  D  G 
Sbjct: 393 ----------------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GI 434

Query: 207 TAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGE 266
              +GS D +IR WD+ +G  +     H+     +EL + ++ SG+AD TVK W   TG+
Sbjct: 435 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ 494

Query: 267 CVRTF---TAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRR 309
           C++T      H+  V+ L+++   + T S D   + +D ++GE  R
Sbjct: 495 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 540



 Score =  151 bits (381), Expect = 1e-36
 Identities = 85/306 (27%), Positives = 146/306 (47%), Gaps = 22/306 (7%)

Query: 42  WSTADGQCCALLQGHESYVTFC-QLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIV 100
           W   + +   +L+GH+ +V  C Q       + S D T++ W  +TG+CL+   GHT  V
Sbjct: 247 WRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 306

Query: 101 NRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEA 160
               + +N + S S DRT +VW+ + G+      GH + V  +                 
Sbjct: 307 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------------ 354

Query: 161 AAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 220
                +V+GS D T +VW + +G C   L GH  AV C+  D  G    +G+ D  ++ W
Sbjct: 355 ----RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVW 408

Query: 221 DILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSA 280
           D  +   L   + H   V  L+     V SGS D +++ W  +TG C+ T T H+   S 
Sbjct: 409 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 468

Query: 281 LKYHAGTLFTGSGDACARAFDAQSGELRRVFRG---HTFIINCIQVHGQVLYTASHDGAL 337
           ++     L +G+ D+  + +D ++G+  +  +G   H   + C+Q +   + T+S DG +
Sbjct: 469 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 528

Query: 338 RLWDVR 343
           +LWD++
Sbjct: 529 KLWDLK 534



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 50/182 (27%), Positives = 84/182 (46%), Gaps = 21/182 (11%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
           G  L V   H   +  +    DG+R+++G+ D   ++W      C   LQGH + V   Q
Sbjct: 373 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 430

Query: 65  LEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSV 124
            +     + S D +IR WDV TG C+    GH S+ + + + +N L S + D T ++W +
Sbjct: 431 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 490

Query: 125 DKGQMSREFRG---HRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181
             GQ  +  +G   H++ V  L ++                   ++T S DGT K+W + 
Sbjct: 491 KTGQCLQTLQGPNKHQSAVTCLQFNK----------------NFVITSSDDGTVKLWDLK 534

Query: 182 SG 183
           +G
Sbjct: 535 TG 536


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  162 bits (411), Expect = 4e-40
 Identities = 91/286 (31%), Positives = 141/286 (49%), Gaps = 21/286 (7%)

Query: 27  GQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLT 86
           G R+++GS+D T ++WS   G+C   L GH   V   Q+ D    + S D T++ W+  T
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAET 450

Query: 87  GQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYS 146
           G+C+    GHTS V  + +   ++ S S D T RVW ++ GQ      GH   V  + Y 
Sbjct: 451 GECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 510

Query: 147 APWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGH 206
                           G  +V+G+ D   KVW   +  C  TL+GHT  V  L  D  G 
Sbjct: 511 ----------------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GI 552

Query: 207 TAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGE 266
              +GS D +IR WD+ +G  +     H+     +EL + ++ SG+AD TVK W   TG+
Sbjct: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ 612

Query: 267 CVRTF---TAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRR 309
           C++T      H+  V+ L+++   + T S D   + +D ++GE  R
Sbjct: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 658



 Score =  151 bits (381), Expect = 1e-36
 Identities = 85/306 (27%), Positives = 146/306 (47%), Gaps = 22/306 (7%)

Query: 42  WSTADGQCCALLQGHESYVTFC-QLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIV 100
           W   + +   +L+GH+ +V  C Q       + S D T++ W  +TG+CL+   GHT  V
Sbjct: 365 WRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 424

Query: 101 NRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEA 160
               + +N + S S DRT +VW+ + G+      GH + V  +                 
Sbjct: 425 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------------ 472

Query: 161 AAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 220
                +V+GS D T +VW + +G C   L GH  AV C+  D  G    +G+ D  ++ W
Sbjct: 473 ----RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVW 526

Query: 221 DILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSA 280
           D  +   L   + H   V  L+     V SGS D +++ W  +TG C+ T T H+   S 
Sbjct: 527 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586

Query: 281 LKYHAGTLFTGSGDACARAFDAQSGELRRVFRG---HTFIINCIQVHGQVLYTASHDGAL 337
           ++     L +G+ D+  + +D ++G+  +  +G   H   + C+Q +   + T+S DG +
Sbjct: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646

Query: 338 RLWDVR 343
           +LWD++
Sbjct: 647 KLWDLK 652



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 50/182 (27%), Positives = 84/182 (46%), Gaps = 21/182 (11%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
           G  L V   H   +  +    DG+R+++G+ D   ++W      C   LQGH + V   Q
Sbjct: 491 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 548

Query: 65  LEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSV 124
            +     + S D +IR WDV TG C+    GH S+ + + + +N L S + D T ++W +
Sbjct: 549 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 608

Query: 125 DKGQMSREFRG---HRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181
             GQ  +  +G   H++ V  L ++                   ++T S DGT K+W + 
Sbjct: 609 KTGQCLQTLQGPNKHQSAVTCLQFNK----------------NFVITSSDDGTVKLWDLK 652

Query: 182 SG 183
           +G
Sbjct: 653 TG 654


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  162 bits (411), Expect = 4e-40
 Identities = 91/286 (31%), Positives = 141/286 (49%), Gaps = 21/286 (7%)

Query: 27  GQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLT 86
           G R+++GS+D T ++WS   G+C   L GH   V   Q+ D    + S D T++ W+  T
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAET 370

Query: 87  GQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYS 146
           G+C+    GHTS V  + +   ++ S S D T RVW ++ GQ      GH   V  + Y 
Sbjct: 371 GECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 430

Query: 147 APWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGH 206
                           G  +V+G+ D   KVW   +  C  TL+GHT  V  L  D  G 
Sbjct: 431 ----------------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GI 472

Query: 207 TAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGE 266
              +GS D +IR WD+ +G  +     H+     +EL + ++ SG+AD TVK W   TG+
Sbjct: 473 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ 532

Query: 267 CVRTF---TAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRR 309
           C++T      H+  V+ L+++   + T S D   + +D ++GE  R
Sbjct: 533 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 578



 Score =  151 bits (381), Expect = 1e-36
 Identities = 85/306 (27%), Positives = 146/306 (47%), Gaps = 22/306 (7%)

Query: 42  WSTADGQCCALLQGHESYVTFC-QLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIV 100
           W   + +   +L+GH+ +V  C Q       + S D T++ W  +TG+CL+   GHT  V
Sbjct: 285 WRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 344

Query: 101 NRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEA 160
               + +N + S S DRT +VW+ + G+      GH + V  +                 
Sbjct: 345 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------------ 392

Query: 161 AAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 220
                +V+GS D T +VW + +G C   L GH  AV C+  D  G    +G+ D  ++ W
Sbjct: 393 ----RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVW 446

Query: 221 DILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSA 280
           D  +   L   + H   V  L+     V SGS D +++ W  +TG C+ T T H+   S 
Sbjct: 447 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 506

Query: 281 LKYHAGTLFTGSGDACARAFDAQSGELRRVFRG---HTFIINCIQVHGQVLYTASHDGAL 337
           ++     L +G+ D+  + +D ++G+  +  +G   H   + C+Q +   + T+S DG +
Sbjct: 507 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 566

Query: 338 RLWDVR 343
           +LWD++
Sbjct: 567 KLWDLK 572



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 50/182 (27%), Positives = 84/182 (46%), Gaps = 21/182 (11%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
           G  L V   H   +  +    DG+R+++G+ D   ++W      C   LQGH + V   Q
Sbjct: 411 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 468

Query: 65  LEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSV 124
            +     + S D +IR WDV TG C+    GH S+ + + + +N L S + D T ++W +
Sbjct: 469 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 528

Query: 125 DKGQMSREFRG---HRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181
             GQ  +  +G   H++ V  L ++                   ++T S DGT K+W + 
Sbjct: 529 KTGQCLQTLQGPNKHQSAVTCLQFNK----------------NFVITSSDDGTVKLWDLK 572

Query: 182 SG 183
           +G
Sbjct: 573 TG 574


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  152 bits (385), Expect = 4e-37
 Identities = 98/332 (29%), Positives = 156/332 (46%), Gaps = 27/332 (8%)

Query: 21  LSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV---TFCQLEDEAAFTCSADC 77
           ++L+  G   +TGS D T +LW TA G+    L+GH + V    F     +   T S D 
Sbjct: 98  VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDK 157

Query: 78  TIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ---LFSSSYDRTARVWSVDKGQMSREFR 134
           T + W V TG+C   +RGHT+ +   L  N Q   + + S D TA++W +  G+     R
Sbjct: 158 TCKLWSVETGKCYHTFRGHTAEIV-CLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216

Query: 135 GHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTG 194
           GH   +++L+++               +G  ++TGS D T  VW   +G     L GH  
Sbjct: 217 GHSAEIISLSFNT--------------SGDRIITGSFDHTVVVWDADTGRKVNILIGHCA 262

Query: 195 AVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI--CLELVNRLVYSGS 252
            +     +       TGS D T + WD  +G+ +     H   ++  C +   +L+ + S
Sbjct: 263 EISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATAS 322

Query: 253 ADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFDAQSGELRRV 310
           AD T + + A T +C+     H   +S + ++     L TGS D  AR +DAQ+G+  +V
Sbjct: 323 ADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382

Query: 311 FRGHT-FIINC-IQVHGQVLYTASHDGALRLW 340
             GHT  I +C     G ++ T S D   R+W
Sbjct: 383 LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score =  117 bits (292), Expect = 2e-26
 Identities = 77/291 (26%), Positives = 124/291 (42%), Gaps = 35/291 (12%)

Query: 5   GSALRVCADHRGGINWLSLS-PDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFC 63
           G  L     HR  +  ++ + P G ++ TGS D T +LWS   G+C    +GH + +   
Sbjct: 124 GEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCL 183

Query: 64  QLEDEAAF--TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRIL--VANNQLFSSSYDRTA 119
               ++    T S D T + WD+  G+ +   RGH++ +  +    + +++ + S+D T 
Sbjct: 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTV 243

Query: 120 RVWSVDKGQMSREFRGHR----------NCVLTLAYSAP-----WDLPSTPCAEEAAA-- 162
            VW  D G+      GH           +C L L  S       WD  +  C        
Sbjct: 244 VVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHD 303

Query: 163 -----------GGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTG 211
                      G L+ T S DGTA+++  A+  C   L GH G +  +  +  G+   TG
Sbjct: 304 DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTG 363

Query: 212 STDATIRAWDILSGEQLRVFREHRGSVI--CLELVNRLVYSGSADRTVKCW 260
           S+D T R WD  +G+ L+V   H   +          +V +GS D T + W
Sbjct: 364 SSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 60/187 (32%), Positives = 86/187 (45%), Gaps = 7/187 (3%)

Query: 162 AGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTP-GHTAFTGSTDATIRAW 220
           +G   +TGS D T K+W  ASG    TL GH   V  +  + P G    TGS D T + W
Sbjct: 103 SGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162

Query: 221 DILSGEQLRVFREHRGSVICLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNV 278
            + +G+    FR H   ++CL     + LV +GS D T K W    GE V T   H   +
Sbjct: 163 SVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEI 222

Query: 279 SALKYHAG--TLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHG--QVLYTASHD 334
            +L ++     + TGS D     +DA +G    +  GH   I+    +    ++ T S D
Sbjct: 223 ISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMD 282

Query: 335 GALRLWD 341
              +LWD
Sbjct: 283 KTCKLWD 289



 Score = 85.9 bits (211), Expect = 5e-17
 Identities = 50/179 (27%), Positives = 83/179 (46%), Gaps = 18/179 (10%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV--TF 62
           G  + +   H   I+  S + D   +LTGS D T +LW   +G+C A L GH+  +  + 
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310

Query: 63  CQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTAR 120
                +   T SAD T R +   T +C+    GH   +++I      N L + S D+TAR
Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370

Query: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQ 179
           +W    GQ  +   GH + + + A++                G +++TGS D T ++W+
Sbjct: 371 IWDAQTGQCLQVLEGHTDEIFSCAFNYK--------------GNIVITGSKDNTCRIWR 415



 Score = 85.1 bits (209), Expect = 9e-17
 Identities = 51/162 (31%), Positives = 76/162 (46%), Gaps = 7/162 (4%)

Query: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR 246
           + L+ H   +  + L+  G    TGS D T + WD  SGE+L     HR  V  +   N 
Sbjct: 86  KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145

Query: 247 L---VYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFD 301
               + +GS D+T K W  +TG+C  TF  H   +  L ++  +  + TGS D  A+ +D
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205

Query: 302 AQSGELRRVFRGHT--FIINCIQVHGQVLYTASHDGALRLWD 341
            Q+GE     RGH+   I       G  + T S D  + +WD
Sbjct: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  142 bits (359), Expect = 4e-34
 Identities = 93/266 (34%), Positives = 124/266 (46%), Gaps = 24/266 (9%)

Query: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
           H G +N  + SPDGQ LLTGSEDG    W T  GQ    L GH   V FC+   +     
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79

Query: 74  SA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQM 129
           SA  DCT+R WDV   +CL+V +GH   V  +  +  + QL S  +D+   +W V  GQM
Sbjct: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139

Query: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVW---QVASGCCH 186
            R   GHR+ + +  +S     P+  C         L TGS D T  +W    V     H
Sbjct: 140 LRLLVGHRDSIQSSDFS-----PTVNC---------LATGSWDSTVHIWDLRMVTPAVSH 185

Query: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR 246
           Q L GH+  + CL     G  A +GS D TI  W   +   L   + H   V  +     
Sbjct: 186 QALEGHSANISCLCYSASGLLA-SGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244

Query: 247 LVYSGSA--DRTVKCWLADTGECVRT 270
            ++  SA   R VK W  +TG+C+ T
Sbjct: 245 ELWLASAGYSRMVKVWDCNTGKCLET 270



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 64/261 (24%), Positives = 101/261 (38%), Gaps = 24/261 (9%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
           G  L     H G + +   SPDG    + S D T RLW  A  +C  +L+GH+  V    
Sbjct: 53  GQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVS 112

Query: 65  LEDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIV--NRILVANNQLFSSSYDRTAR 120
              ++    S   D  +  WDV +GQ L++  GH   +  +      N L + S+D T  
Sbjct: 113 FSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVH 172

Query: 121 VWS---VDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKV 177
           +W    V      +   GH   +  L YS               A GLL +GS D T  +
Sbjct: 173 IWDLRMVTPAVSHQALEGHSANISCLCYS---------------ASGLLASGSWDKTIHI 217

Query: 178 WQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFRE--HR 235
           W+  +      L+GH   V  +          +      ++ WD  +G+ L   +     
Sbjct: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277

Query: 236 GSVICLELVNRLVYSGSADRT 256
                     +++ SG+AD+T
Sbjct: 278 AHTCAFTPDGKILVSGAADQT 298



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 46/158 (29%), Positives = 65/158 (41%), Gaps = 6/158 (3%)

Query: 192 HTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVY 249
           H G V        G    TGS D  +  W+  SG+ L     H G V          L  
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79

Query: 250 SGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGT--LFTGSGDACARAFDAQSGEL 307
           S S D TV+ W     +C+R    H+R+V  + +   +  L +G  D     +D QSG++
Sbjct: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139

Query: 308 RRVFRGHTFIINCIQVHGQV--LYTASHDGALRLWDVR 343
            R+  GH   I        V  L T S D  + +WD+R
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177


>gi|11968023 zinc finger protein 106 homolog [Homo sapiens]
          Length = 1883

 Score =  126 bits (316), Expect = 4e-29
 Identities = 85/293 (29%), Positives = 140/293 (47%), Gaps = 25/293 (8%)

Query: 54   QGHESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVA-----NN 108
            +GH++ V   Q+     +TCSAD T+R +++++ +C+ V+ GHTS VN +LV      N 
Sbjct: 1528 EGHQAAVNAIQIFGNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKNA 1587

Query: 109  QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVT 168
             L++ S D T R ++V            R CV  L            C    +   +L  
Sbjct: 1588 ALYTGSSDHTIRCYNVKS----------RECVEQLQLE-----DRVLCLH--SRWRILYA 1630

Query: 169  GSTDGTAKVWQVASGCCHQTLRGH-TGAVLCLVLDTPG--HTAFTGSTDATIRAWDILSG 225
            G  +GT   + + +    +    H   AV CL     G       GS D TI   D  +G
Sbjct: 1631 GLANGTVVTFNIKNNKRLEIFECHGPRAVSCLATAQEGARKLLVVGSYDCTISVRDARNG 1690

Query: 226  EQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
              LR    H  +++C+++VN LV+SGS+D++V      TGE VR +  H   V+ +    
Sbjct: 1691 LLLRTLEGHSKTILCMKVVNDLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNILG 1750

Query: 286  GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALR 338
              + T   D   R ++ QS +  +V+ GH  +I C+ +H  ++YT  +DG+++
Sbjct: 1751 KVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKSMIYTGCYDGSIQ 1803



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 26/128 (20%), Positives = 66/128 (51%), Gaps = 2/128 (1%)

Query: 18   INWLSLSPDGQR--LLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSA 75
            ++ L+ + +G R  L+ GS D T  +    +G     L+GH   +   ++ ++  F+ S+
Sbjct: 1659 VSCLATAQEGARKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVNDLVFSGSS 1718

Query: 76   DCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRG 135
            D ++   ++ TG+ +++Y+GH   V  + +    + ++  D+  RV+ +      + + G
Sbjct: 1719 DQSVHAHNIHTGELVRIYKGHNHAVTVVNILGKVMVTACLDKFVRVYELQSHDRLQVYGG 1778

Query: 136  HRNCVLTL 143
            H++ ++ +
Sbjct: 1779 HKDMIMCM 1786



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 5/79 (6%)

Query: 270  TFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQV-----H 324
            +F  H+  V+A++     L+T S D   R ++  S +   VF GHT  +NC+ V      
Sbjct: 1526 SFEGHQAAVNAIQIFGNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGK 1585

Query: 325  GQVLYTASHDGALRLWDVR 343
               LYT S D  +R ++V+
Sbjct: 1586 NAALYTGSSDHTIRCYNVK 1604


>gi|4502477 beta-transducin repeat containing protein isoform 2
           [Homo sapiens]
          Length = 569

 Score =  122 bits (307), Expect = 4e-28
 Identities = 98/344 (28%), Positives = 143/344 (41%), Gaps = 54/344 (15%)

Query: 23  LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82
           L  D Q++++G  D T ++W     +C  +L GH   V   Q ++    T S+D T+R W
Sbjct: 273 LQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVW 332

Query: 83  DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139
           DV TG+ L     H   V  +   N  + + S DR+  VW +       + R   GHR  
Sbjct: 333 DVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 392

Query: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
           V  + +   +                +V+ S D T KVW  ++    +TL GH   + C 
Sbjct: 393 VNVVDFDDKY----------------IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIAC- 435

Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259
            L        +GS+D TIR WDI  G  LRV   H   V C+   N+ + SG+ D  +K 
Sbjct: 436 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 494

Query: 260 WLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIIN 319
           W                 V+AL   A      +G  C R     SG   RVFR       
Sbjct: 495 W---------------DLVAALDPRA-----PAGTLCLRTLVEHSG---RVFR------- 524

Query: 320 CIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSRLFS 363
            +Q     + ++SHD  + +WD      A   PP  RS SR ++
Sbjct: 525 -LQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPP--RSPSRTYT 565



 Score =  108 bits (271), Expect = 6e-24
 Identities = 73/264 (27%), Positives = 114/264 (43%), Gaps = 32/264 (12%)

Query: 9   RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 68
           R+   H G +  L L  D + ++TGS D T R+W    G+    L  H   V   +  + 
Sbjct: 301 RILTGHTGSV--LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG 358

Query: 69  AAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSVD 125
              TCS D +I  WD+ +   + + R   GH + VN +   +  + S+S DRT +VW+  
Sbjct: 359 MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTS 418

Query: 126 KGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCC 185
             +  R   GH+  +  L Y                   L+V+GS+D T ++W +  G C
Sbjct: 419 TCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGAC 462

Query: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHRG 236
            + L GH   V C+  D       +G+ D  I+ WD+++            LR   EH G
Sbjct: 463 LRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSG 520

Query: 237 SVICLELVNRLVYSGSADRTVKCW 260
            V  L+     + S S D T+  W
Sbjct: 521 RVFRLQFDEFQIVSSSHDDTILIW 544



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 32/105 (30%), Positives = 55/105 (52%)

Query: 238 VICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACA 297
           V CL+  ++ + SG  D T+K W  +T EC R  T H  +V  L+Y    + TGS D+  
Sbjct: 270 VYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTV 329

Query: 298 RAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342
           R +D  +GE+      H   +  ++ +  ++ T S D ++ +WD+
Sbjct: 330 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDM 374



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 21/67 (31%), Positives = 36/67 (53%)

Query: 276 RNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDG 335
           + V  L+Y    + +G  D   + +D  + E +R+  GHT  + C+Q   +V+ T S D 
Sbjct: 268 KGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDS 327

Query: 336 ALRLWDV 342
            +R+WDV
Sbjct: 328 TVRVWDV 334


>gi|16117783 beta-transducin repeat containing protein isoform 1
           [Homo sapiens]
          Length = 605

 Score =  122 bits (307), Expect = 4e-28
 Identities = 98/344 (28%), Positives = 143/344 (41%), Gaps = 54/344 (15%)

Query: 23  LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82
           L  D Q++++G  D T ++W     +C  +L GH   V   Q ++    T S+D T+R W
Sbjct: 309 LQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVW 368

Query: 83  DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139
           DV TG+ L     H   V  +   N  + + S DR+  VW +       + R   GHR  
Sbjct: 369 DVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 428

Query: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
           V  + +   +                +V+ S D T KVW  ++    +TL GH   + C 
Sbjct: 429 VNVVDFDDKY----------------IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIAC- 471

Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259
            L        +GS+D TIR WDI  G  LRV   H   V C+   N+ + SG+ D  +K 
Sbjct: 472 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 530

Query: 260 WLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIIN 319
           W                 V+AL   A      +G  C R     SG   RVFR       
Sbjct: 531 W---------------DLVAALDPRA-----PAGTLCLRTLVEHSG---RVFR------- 560

Query: 320 CIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSRLFS 363
            +Q     + ++SHD  + +WD      A   PP  RS SR ++
Sbjct: 561 -LQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPP--RSPSRTYT 601



 Score =  108 bits (271), Expect = 6e-24
 Identities = 73/264 (27%), Positives = 114/264 (43%), Gaps = 32/264 (12%)

Query: 9   RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 68
           R+   H G +  L L  D + ++TGS D T R+W    G+    L  H   V   +  + 
Sbjct: 337 RILTGHTGSV--LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG 394

Query: 69  AAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSVD 125
              TCS D +I  WD+ +   + + R   GH + VN +   +  + S+S DRT +VW+  
Sbjct: 395 MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTS 454

Query: 126 KGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCC 185
             +  R   GH+  +  L Y                   L+V+GS+D T ++W +  G C
Sbjct: 455 TCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGAC 498

Query: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHRG 236
            + L GH   V C+  D       +G+ D  I+ WD+++            LR   EH G
Sbjct: 499 LRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSG 556

Query: 237 SVICLELVNRLVYSGSADRTVKCW 260
            V  L+     + S S D T+  W
Sbjct: 557 RVFRLQFDEFQIVSSSHDDTILIW 580



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 32/105 (30%), Positives = 55/105 (52%)

Query: 238 VICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACA 297
           V CL+  ++ + SG  D T+K W  +T EC R  T H  +V  L+Y    + TGS D+  
Sbjct: 306 VYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTV 365

Query: 298 RAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342
           R +D  +GE+      H   +  ++ +  ++ T S D ++ +WD+
Sbjct: 366 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDM 410



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 21/67 (31%), Positives = 36/67 (53%)

Query: 276 RNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDG 335
           + V  L+Y    + +G  D   + +D  + E +R+  GHT  + C+Q   +V+ T S D 
Sbjct: 304 KGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDS 363

Query: 336 ALRLWDV 342
            +R+WDV
Sbjct: 364 TVRVWDV 370


>gi|48928050 F-box and WD repeat domain containing 11 isoform C
           [Homo sapiens]
          Length = 542

 Score =  120 bits (301), Expect = 2e-27
 Identities = 73/249 (29%), Positives = 117/249 (46%), Gaps = 22/249 (8%)

Query: 107 NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLL 166
           + ++ S   D + ++W     +  +   GH   VL L Y                   ++
Sbjct: 250 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER----------------VI 293

Query: 167 VTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGE 226
           VTGS+D T +VW V +G    TL  H  AVL L          T S D +I  WD+ S  
Sbjct: 294 VTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAVWDMASAT 351

Query: 227 QL---RVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKY 283
            +   RV   HR +V  ++  ++ + S S DRT+K W   T E VRT   H+R ++ L+Y
Sbjct: 352 DITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY 411

Query: 284 HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVR 343
               + +GS D   R +D + G   RV  GH  ++ CI+   + + + ++DG +++WD++
Sbjct: 412 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQ 471

Query: 344 GLRGAPRPP 352
                PR P
Sbjct: 472 AALD-PRAP 479



 Score =  119 bits (299), Expect = 3e-27
 Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 36/313 (11%)

Query: 23  LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82
           L  D +++++G  D + ++W     +C  +L GH   V   Q ++    T S+D T+R W
Sbjct: 246 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVW 305

Query: 83  DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139
           DV TG+ L     H   V  +  +N  + + S DR+  VW +       + R   GHR  
Sbjct: 306 DVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 365

Query: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
           V  + +   +                +V+ S D T KVW  ++    +TL GH   + C 
Sbjct: 366 VNVVDFDDKY----------------IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIAC- 408

Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259
            L        +GS+D TIR WDI  G  LRV   H   V C+   N+ + SG+ D  +K 
Sbjct: 409 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 467

Query: 260 W---------LADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFD------AQS 304
           W            +  C+RT   H   V  L++    + + S D     +D      +  
Sbjct: 468 WDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQ 527

Query: 305 GELRRVFRGHTFI 317
            E R   R +T+I
Sbjct: 528 NETRSPSRTYTYI 540



 Score =  111 bits (278), Expect = 9e-25
 Identities = 75/265 (28%), Positives = 114/265 (43%), Gaps = 32/265 (12%)

Query: 8   LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 67
           L+V   H G +  L L  D + ++TGS D T R+W    G+    L  H   V   +  +
Sbjct: 273 LKVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 330

Query: 68  EAAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSV 124
               TCS D +I  WD+ +   + + R   GH + VN +   +  + S+S DRT +VWS 
Sbjct: 331 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 390

Query: 125 DKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC 184
              +  R   GH+  +  L Y                   L+V+GS+D T ++W +  G 
Sbjct: 391 STCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGA 434

Query: 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHR 235
           C + L GH   V C+  D       +G+ D  I+ WD+ +            LR   EH 
Sbjct: 435 CLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS 492

Query: 236 GSVICLELVNRLVYSGSADRTVKCW 260
           G V  L+     + S S D T+  W
Sbjct: 493 GRVFRLQFDEFQIISSSHDDTILIW 517



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 30/117 (25%), Positives = 59/117 (50%)

Query: 226 EQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
           ++++   E+   V CL+  +  + SG  D ++K W   + EC++  T H  +V  L+Y  
Sbjct: 231 QRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE 290

Query: 286 GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342
             + TGS D+  R +D  +GE+      H   +  ++    ++ T S D ++ +WD+
Sbjct: 291 RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDM 347


>gi|48928048 F-box and WD repeat domain containing 11 isoform A
           [Homo sapiens]
          Length = 508

 Score =  120 bits (301), Expect = 2e-27
 Identities = 73/249 (29%), Positives = 117/249 (46%), Gaps = 22/249 (8%)

Query: 107 NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLL 166
           + ++ S   D + ++W     +  +   GH   VL L Y                   ++
Sbjct: 216 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER----------------VI 259

Query: 167 VTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGE 226
           VTGS+D T +VW V +G    TL  H  AVL L          T S D +I  WD+ S  
Sbjct: 260 VTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAVWDMASAT 317

Query: 227 QL---RVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKY 283
            +   RV   HR +V  ++  ++ + S S DRT+K W   T E VRT   H+R ++ L+Y
Sbjct: 318 DITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY 377

Query: 284 HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVR 343
               + +GS D   R +D + G   RV  GH  ++ CI+   + + + ++DG +++WD++
Sbjct: 378 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQ 437

Query: 344 GLRGAPRPP 352
                PR P
Sbjct: 438 AALD-PRAP 445



 Score =  119 bits (299), Expect = 3e-27
 Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 36/313 (11%)

Query: 23  LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82
           L  D +++++G  D + ++W     +C  +L GH   V   Q ++    T S+D T+R W
Sbjct: 212 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVW 271

Query: 83  DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139
           DV TG+ L     H   V  +  +N  + + S DR+  VW +       + R   GHR  
Sbjct: 272 DVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 331

Query: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
           V  + +   +                +V+ S D T KVW  ++    +TL GH   + C 
Sbjct: 332 VNVVDFDDKY----------------IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIAC- 374

Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259
            L        +GS+D TIR WDI  G  LRV   H   V C+   N+ + SG+ D  +K 
Sbjct: 375 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 433

Query: 260 W---------LADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFD------AQS 304
           W            +  C+RT   H   V  L++    + + S D     +D      +  
Sbjct: 434 WDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQ 493

Query: 305 GELRRVFRGHTFI 317
            E R   R +T+I
Sbjct: 494 NETRSPSRTYTYI 506



 Score =  111 bits (278), Expect = 9e-25
 Identities = 75/265 (28%), Positives = 114/265 (43%), Gaps = 32/265 (12%)

Query: 8   LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 67
           L+V   H G +  L L  D + ++TGS D T R+W    G+    L  H   V   +  +
Sbjct: 239 LKVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 296

Query: 68  EAAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSV 124
               TCS D +I  WD+ +   + + R   GH + VN +   +  + S+S DRT +VWS 
Sbjct: 297 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 356

Query: 125 DKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC 184
              +  R   GH+  +  L Y                   L+V+GS+D T ++W +  G 
Sbjct: 357 STCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGA 400

Query: 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHR 235
           C + L GH   V C+  D       +G+ D  I+ WD+ +            LR   EH 
Sbjct: 401 CLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS 458

Query: 236 GSVICLELVNRLVYSGSADRTVKCW 260
           G V  L+     + S S D T+  W
Sbjct: 459 GRVFRLQFDEFQIISSSHDDTILIW 483



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 30/117 (25%), Positives = 59/117 (50%)

Query: 226 EQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
           ++++   E+   V CL+  +  + SG  D ++K W   + EC++  T H  +V  L+Y  
Sbjct: 197 QRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE 256

Query: 286 GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342
             + TGS D+  R +D  +GE+      H   +  ++    ++ T S D ++ +WD+
Sbjct: 257 RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDM 313


>gi|48928046 F-box and WD repeat domain containing 11 isoform B
           [Homo sapiens]
          Length = 529

 Score =  120 bits (301), Expect = 2e-27
 Identities = 73/249 (29%), Positives = 117/249 (46%), Gaps = 22/249 (8%)

Query: 107 NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLL 166
           + ++ S   D + ++W     +  +   GH   VL L Y                   ++
Sbjct: 237 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER----------------VI 280

Query: 167 VTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGE 226
           VTGS+D T +VW V +G    TL  H  AVL L          T S D +I  WD+ S  
Sbjct: 281 VTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAVWDMASAT 338

Query: 227 QL---RVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKY 283
            +   RV   HR +V  ++  ++ + S S DRT+K W   T E VRT   H+R ++ L+Y
Sbjct: 339 DITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY 398

Query: 284 HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVR 343
               + +GS D   R +D + G   RV  GH  ++ CI+   + + + ++DG +++WD++
Sbjct: 399 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQ 458

Query: 344 GLRGAPRPP 352
                PR P
Sbjct: 459 AALD-PRAP 466



 Score =  119 bits (299), Expect = 3e-27
 Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 36/313 (11%)

Query: 23  LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82
           L  D +++++G  D + ++W     +C  +L GH   V   Q ++    T S+D T+R W
Sbjct: 233 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVW 292

Query: 83  DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139
           DV TG+ L     H   V  +  +N  + + S DR+  VW +       + R   GHR  
Sbjct: 293 DVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 352

Query: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
           V  + +   +                +V+ S D T KVW  ++    +TL GH   + C 
Sbjct: 353 VNVVDFDDKY----------------IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIAC- 395

Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259
            L        +GS+D TIR WDI  G  LRV   H   V C+   N+ + SG+ D  +K 
Sbjct: 396 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 454

Query: 260 W---------LADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFD------AQS 304
           W            +  C+RT   H   V  L++    + + S D     +D      +  
Sbjct: 455 WDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQ 514

Query: 305 GELRRVFRGHTFI 317
            E R   R +T+I
Sbjct: 515 NETRSPSRTYTYI 527



 Score =  111 bits (278), Expect = 9e-25
 Identities = 75/265 (28%), Positives = 114/265 (43%), Gaps = 32/265 (12%)

Query: 8   LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 67
           L+V   H G +  L L  D + ++TGS D T R+W    G+    L  H   V   +  +
Sbjct: 260 LKVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 317

Query: 68  EAAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSV 124
               TCS D +I  WD+ +   + + R   GH + VN +   +  + S+S DRT +VWS 
Sbjct: 318 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 377

Query: 125 DKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC 184
              +  R   GH+  +  L Y                   L+V+GS+D T ++W +  G 
Sbjct: 378 STCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGA 421

Query: 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHR 235
           C + L GH   V C+  D       +G+ D  I+ WD+ +            LR   EH 
Sbjct: 422 CLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS 479

Query: 236 GSVICLELVNRLVYSGSADRTVKCW 260
           G V  L+     + S S D T+  W
Sbjct: 480 GRVFRLQFDEFQIISSSHDDTILIW 504



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 30/117 (25%), Positives = 59/117 (50%)

Query: 226 EQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
           ++++   E+   V CL+  +  + SG  D ++K W   + EC++  T H  +V  L+Y  
Sbjct: 218 QRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE 277

Query: 286 GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342
             + TGS D+  R +D  +GE+      H   +  ++    ++ T S D ++ +WD+
Sbjct: 278 RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDM 334


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  115 bits (289), Expect = 5e-26
 Identities = 77/270 (28%), Positives = 122/270 (45%), Gaps = 16/270 (5%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
           G   R    H   +  +S    G+ L + S D T +LW     +C   + GH+  V+   
Sbjct: 140 GDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVA 199

Query: 65  L--EDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ----LFSSSYDRT 118
           +    +   + S D TI+ W+V TG C++ + GH   V   +V  NQ    + S S D+T
Sbjct: 200 IMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVR--MVRPNQDGTLIASCSNDQT 257

Query: 119 ARVWSVDKGQMSREFRGHRNCVLTLA------YSAPWDLPSTPCAEEAAAGGLLVTGSTD 172
            RVW V   +   E R H + V  ++      YS+  +   +   +    G  L++GS D
Sbjct: 258 VRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317

Query: 173 GTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFR 232
            T K+W V++G C  TL GH   V  ++  + G    + + D T+R WD  +   ++   
Sbjct: 318 KTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLN 377

Query: 233 EHRGSVICLELVNRLVY--SGSADRTVKCW 260
            H   V  L+      Y  +GS D+TVK W
Sbjct: 378 AHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407



 Score =  114 bits (286), Expect = 1e-25
 Identities = 82/318 (25%), Positives = 133/318 (41%), Gaps = 42/318 (13%)

Query: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF-- 71
           HR  +  +   P    +++ SED T ++W    G     L+GH   V     +       
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166

Query: 72  TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN--QLFSSSYDRTARVWSVDKGQM 129
           +CSAD TI+ WD    +C++   GH   V+ + +  N   + S+S D+T ++W V  G  
Sbjct: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226

Query: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTL 189
            + F GHR  V  +  +                G L+ + S D T +VW VA+  C   L
Sbjct: 227 VKTFTGHREWVRMVRPNQD--------------GTLIASCSNDQTVRVWVVATKECKAEL 272

Query: 190 RGHTGAVLCL--------------------VLDTPGHTAFTGSTDATIRAWDILSGEQLR 229
           R H   V C+                        PG    +GS D TI+ WD+ +G  L 
Sbjct: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332

Query: 230 VFREHRGSV--ICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--A 285
               H   V  +      + + S + D+T++ W      C++T  AH   V++L +H  A
Sbjct: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTA 392

Query: 286 GTLFTGSGDACARAFDAQ 303
             + TGS D   + ++ +
Sbjct: 393 PYVVTGSVDQTVKVWECR 410



 Score =  107 bits (268), Expect = 1e-23
 Identities = 86/321 (26%), Positives = 130/321 (40%), Gaps = 44/321 (13%)

Query: 53  LQGHESYVTFCQLEDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANN 108
           L GH S VT        +   SA  D TI+ WD  TG   +  +GHT  V  I    +  
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163

Query: 109 QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVT 168
            L S S D T ++W     +  R   GH + V ++A      +P+         G  +V+
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAI-----MPN---------GDHIVS 209

Query: 169 GSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL 228
            S D T K+W+V +G C +T  GH   V  +  +  G    + S D T+R W + + E  
Sbjct: 210 ASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECK 269

Query: 229 RVFREHRGSVICLELVNRLVYS----------------------GSADRTVKCWLADTGE 266
              REH   V C+       YS                      GS D+T+K W   TG 
Sbjct: 270 AELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGM 329

Query: 267 CVRTFTAHRRNVSALKYHAGTLF--TGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH 324
           C+ T   H   V  + +H+G  F  + + D   R +D ++    +    H   +  +  H
Sbjct: 330 CLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFH 389

Query: 325 GQVLY--TASHDGALRLWDVR 343
               Y  T S D  +++W+ R
Sbjct: 390 KTAPYVVTGSVDQTVKVWECR 410


>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
          Length = 670

 Score =  115 bits (289), Expect = 5e-26
 Identities = 83/294 (28%), Positives = 139/294 (47%), Gaps = 27/294 (9%)

Query: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADG-QCCALLQGHESYVTFCQLEDEAAFT 72
           H+G +  L +   G  L +GS D T ++W T    +C   L+GH+  V    ++    ++
Sbjct: 395 HQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYS 454

Query: 73  CSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSV--DKGQMS 130
            SADCTI  WD+   Q +   R H + V  ++ ++N LFS S  +  +VW +   + ++ 
Sbjct: 455 GSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIKVWDIVGTELKLK 513

Query: 131 REFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLR 190
           +E  G  + V  L                 AA   L +GS   T K+W + +  C   L+
Sbjct: 514 KELTGLNHWVRAL----------------VAAQSYLYSGSYQ-TIKIWDIRTLDCIHVLQ 556

Query: 191 GHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVN----R 246
              G+V  + +    H    G+ +  I  WDI S EQ+R    H G+V  L +++     
Sbjct: 557 TSGGSVYSIAV--TNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQT 614

Query: 247 LVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAF 300
            V+S S DR+++ W  D   C +T   H+ +V+AL    G LF+G+ D+  + +
Sbjct: 615 KVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 76/302 (25%), Positives = 121/302 (40%), Gaps = 29/302 (9%)

Query: 48  QCCALLQGHESYV-TFCQLE-DEAAFTCSADCTIRRWDVLTG-QCLQVYRGHTSIVNRIL 104
           +C     GH+  V   C     +  F+ S+D TI+ WD  T  +C +   GH  IV  + 
Sbjct: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446

Query: 105 VANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGG 164
           +   +L+S S D T  VW +   Q     R H N V TL  S                  
Sbjct: 447 IQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSH----------------N 490

Query: 165 LLVTGSTDGTAKVWQVASG--CCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
           +L +GS     KVW +        + L G    V  LV        ++GS   TI+ WDI
Sbjct: 491 VLFSGSLKAI-KVWDIVGTELKLKKELTGLNHWVRALV--AAQSYLYSGSYQ-TIKIWDI 546

Query: 223 LSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALK 282
            + + + V +   GSV  + + N  +  G+ +  +  W  ++ E VRT T H   V AL 
Sbjct: 547 RTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALA 606

Query: 283 Y----HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALR 338
                    +F+ S D   R +   +    +    H   +  + V    L++ + D  ++
Sbjct: 607 VISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVK 666

Query: 339 LW 340
           +W
Sbjct: 667 VW 668



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 70/265 (26%), Positives = 114/265 (43%), Gaps = 31/265 (11%)

Query: 88  QCLQVYRGHTSIVNRILVAN--NQLFSSSYDRTARVWSV-DKGQMSREFRGHRNCVLTLA 144
           +C   + GH   V  + V +  + LFS S D+T +VW      +  +   GH   VL L 
Sbjct: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446

Query: 145 YSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTP 204
                             G  L +GS D T  VW + +     T+R H   V  LV  + 
Sbjct: 447 IQ----------------GCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLV--SS 488

Query: 205 GHTAFTGSTDATIRAWDILSGEQLRVFREHRGS---VICLELVNRLVYSGSADRTVKCWL 261
            +  F+GS  A I+ WDI+ G +L++ +E  G    V  L      +YSGS  +T+K W 
Sbjct: 489 HNVLFSGSLKA-IKVWDIV-GTELKLKKELTGLNHWVRALVAAQSYLYSGSY-QTIKIWD 545

Query: 262 ADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCI 321
             T +C+        +V ++      +  G+ +     +D +S E  R   GH   +  +
Sbjct: 546 IRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYAL 605

Query: 322 QVHGQV----LYTASHDGALRLWDV 342
            V        +++AS+D +LR+W +
Sbjct: 606 AVISTPDQTKVFSASYDRSLRVWSM 630



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 24/106 (22%), Positives = 44/106 (41%), Gaps = 4/106 (3%)

Query: 22  SLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL----EDEAAFTCSADC 77
           S++     ++ G+ +    +W     +    L GH   V    +    +    F+ S D 
Sbjct: 564 SIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDR 623

Query: 78  TIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWS 123
           ++R W +    C Q    H   V  + V+  +LFS + D T +VW+
Sbjct: 624 SLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWT 669



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 23/84 (27%), Positives = 43/84 (51%), Gaps = 3/84 (3%)

Query: 266 ECVRTFTAHRRNVSALKYHA--GTLFTGSGDACARAFDA-QSGELRRVFRGHTFIINCIQ 322
           +C  TF  H+  V  L  ++    LF+GS D   + +D   + + ++   GH  I+  + 
Sbjct: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446

Query: 323 VHGQVLYTASHDGALRLWDVRGLR 346
           + G  LY+ S D  + +WD++ L+
Sbjct: 447 IQGCKLYSGSADCTIIVWDIQNLQ 470


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  114 bits (285), Expect = 1e-25
 Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 24/281 (8%)

Query: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
           H   ++ +  SP+G+ L + S D    +W   DG+    L GH   ++      +++   
Sbjct: 40  HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99

Query: 74  SA--DCTIRRWDVLTGQCLQVYRGHTSIV--NRILVANNQLFSSSYDRTARVWSVDKGQM 129
           SA  D T++ WDV +G+CL+  +GH++ V        +N + S S+D T ++W V  G+ 
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159

Query: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTL 189
            +    H + V  + ++               +G L+V+GS DG  ++W  ASG C +TL
Sbjct: 160 LKTLSAHSDPVSAVHFN--------------CSGSLIVSGSYDGLCRIWDAASGQCLKTL 205

Query: 190 RGHTGAVLCLVLDTP-GHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL-----EL 243
                  +  V  +P G    T + D T++ WD   G  L+ +  H+    C+       
Sbjct: 206 VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVT 265

Query: 244 VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH 284
             + + SGS D  V  W   T E V+    H   V +   H
Sbjct: 266 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACH 306



 Score =  108 bits (270), Expect = 8e-24
 Identities = 71/261 (27%), Positives = 120/261 (45%), Gaps = 24/261 (9%)

Query: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
           H   I+ ++ S D  RL++ S+D T +LW    G+C   L+GH +YV  C     +    
Sbjct: 82  HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLII 141

Query: 74  SA--DCTIRRWDVLTGQCLQVYRGHTSIVNRI--LVANNQLFSSSYDRTARVWSVDKGQM 129
           S   D T++ W+V TG+CL+    H+  V+ +    + + + S SYD   R+W    GQ 
Sbjct: 142 SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ- 200

Query: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTL 189
                    C+ TL      D P     + +  G  ++T + D T K+W  + G C +T 
Sbjct: 201 ---------CLKTLVDD---DNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY 248

Query: 190 RGHTGAVLCLVLD---TPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI---CLEL 243
            GH     C+  +   T G    +GS D  +  W++ + E ++  + H   VI   C   
Sbjct: 249 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPT 308

Query: 244 VNRLVYSG-SADRTVKCWLAD 263
            N +  +    D+T+K W+++
Sbjct: 309 ENLIASAALENDKTIKLWMSN 329



 Score =  104 bits (259), Expect = 1e-22
 Identities = 73/304 (24%), Positives = 134/304 (44%), Gaps = 30/304 (9%)

Query: 53  LQGHESYVTFCQLEDEAAF--TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN-- 108
           L GH   V+  +      +  + SAD  I  W    G+  +   GH   ++ +  +++  
Sbjct: 37  LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96

Query: 109 QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVT 168
           +L S+S D+T ++W V  G+  +  +GH N V    ++ P                L+++
Sbjct: 97  RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPP--------------SNLIIS 142

Query: 169 GSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL 228
           GS D T K+W+V +G C +TL  H+  V  +  +  G    +GS D   R WD  SG+ L
Sbjct: 143 GSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCL 202

Query: 229 RVFREHRG---SVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
           +   +      S +      + + + + D T+K W    G C++T+T H+     +  + 
Sbjct: 203 KTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANF 262

Query: 286 GT-----LFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTAS----HDGA 336
                  + +GS D     ++ Q+ E+ +  +GHT ++     H      AS    +D  
Sbjct: 263 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKT 322

Query: 337 LRLW 340
           ++LW
Sbjct: 323 IKLW 326



 Score =  100 bits (249), Expect = 2e-21
 Identities = 69/261 (26%), Positives = 119/261 (45%), Gaps = 26/261 (9%)

Query: 95  GHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLP 152
           GHT  V+ +  + N   L SSS DR   +W    G+  +   GH   +  +A+S+     
Sbjct: 39  GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD---- 94

Query: 153 STPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS 212
                        LV+ S D T K+W V SG C +TL+GH+  V C   + P +   +GS
Sbjct: 95  ----------SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGS 144

Query: 213 TDATIRAWDILSGEQLRVFREHRG--SVICLELVNRLVYSGSADRTVKCWLADTGECVRT 270
            D T++ W++ +G+ L+    H    S +       L+ SGS D   + W A +G+C++T
Sbjct: 145 FDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKT 204

Query: 271 FT-AHRRNVSALKY--HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--- 324
                   VS +K+  +   + T + D   + +D   G   + + GH     CI  +   
Sbjct: 205 LVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSV 264

Query: 325 --GQVLYTASHDGALRLWDVR 343
             G+ + + S D  + +W+++
Sbjct: 265 TGGKWIVSGSEDNLVYIWNLQ 285



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 43/182 (23%), Positives = 80/182 (43%), Gaps = 20/182 (10%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCC-ALLQGHESYVTFC 63
           G  L+  + H   ++ +  +  G  +++GS DG  R+W  A GQC   L+      V+F 
Sbjct: 157 GKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV 216

Query: 64  QLEDEAAF--TCSADCTIRRWDVLTGQCLQVYRGHTS-----IVNRILVANNQLFSSSYD 116
           +      +  T + D T++ WD   G+CL+ Y GH +       N  +     + S S D
Sbjct: 217 KFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 276

Query: 117 RTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAK 176
               +W++   ++ ++ +GH + V++ A     +L ++   E             D T K
Sbjct: 277 NLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALE------------NDKTIK 324

Query: 177 VW 178
           +W
Sbjct: 325 LW 326



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 51/227 (22%), Positives = 93/227 (40%), Gaps = 26/227 (11%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
           G  L+    H   +   + +P    +++GS D T ++W    G+C   L  H   V+   
Sbjct: 115 GKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVH 174

Query: 65  LEDEAAFTCSA--DCTIRRWDVLTGQCLQ-VYRGHTSIVNRILVANN--QLFSSSYDRTA 119
                +   S   D   R WD  +GQCL+ +       V+ +  + N   + +++ D T 
Sbjct: 175 FNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTL 234

Query: 120 RVWSVDKGQMSREFRGHRN---CVLTLAYSAPWDLPSTPCAEEAAAGG-LLVTGSTDGTA 175
           ++W   +G+  + + GH+N   C+                A  +  GG  +V+GS D   
Sbjct: 235 KLWDYSRGRCLKTYTGHKNEKYCIF---------------ANFSVTGGKWIVSGSEDNLV 279

Query: 176 KVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS--TDATIRAW 220
            +W + +    Q L+GHT  V+        +   + +   D TI+ W
Sbjct: 280 YIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  110 bits (276), Expect = 2e-24
 Identities = 72/283 (25%), Positives = 125/283 (44%), Gaps = 24/283 (8%)

Query: 12  ADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF 71
           A H   ++ +  SP+G+ L + S D   ++W   DG+    + GH+  ++      ++  
Sbjct: 42  AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101

Query: 72  TCSA--DCTIRRWDVLTGQCLQVYRGHTSIV--NRILVANNQLFSSSYDRTARVWSVDKG 127
             SA  D T++ WDV +G+CL+  +GH++ V        +N + S S+D + R+W V  G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161

Query: 128 QMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQ 187
           +  +    H + V  + ++                G L+V+ S DG  ++W  ASG C +
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRD--------------GSLIVSSSYDGLCRIWDTASGQCLK 207

Query: 188 TLRGHTGAVLCLVLDTP-GHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL----- 241
           TL       +  V  +P G      + D T++ WD   G+ L+ +  H+    C+     
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267

Query: 242 ELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH 284
               + + SGS D  V  W   T E V+    H   V +   H
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310



 Score =  110 bits (276), Expect = 2e-24
 Identities = 73/270 (27%), Positives = 124/270 (45%), Gaps = 24/270 (8%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
           G   +  + H+ GI+ ++ S D   L++ S+D T ++W  + G+C   L+GH +YV  C 
Sbjct: 77  GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136

Query: 65  LEDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTAR 120
              ++    S   D ++R WDV TG+CL+    H+  V+ +      + + SSSYD   R
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196

Query: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV 180
           +W    GQ          C+ TL      D P     + +  G  ++  + D T K+W  
Sbjct: 197 IWDTASGQ----------CLKTLIDD---DNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243

Query: 181 ASGCCHQTLRGHTGAVLCLVLD---TPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGS 237
           + G C +T  GH     C+  +   T G    +GS D  +  W++ + E ++  + H   
Sbjct: 244 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303

Query: 238 VI---CLELVNRLVYSG-SADRTVKCWLAD 263
           VI   C    N +  +    D+T+K W +D
Sbjct: 304 VISTACHPTENIIASAALENDKTIKLWKSD 333



 Score =  101 bits (252), Expect = 1e-21
 Identities = 72/304 (23%), Positives = 131/304 (43%), Gaps = 30/304 (9%)

Query: 53  LQGHESYVTFCQLEDEAAF--TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVAN--N 108
           L GH   V+  +      +  + SAD  I+ W    G+  +   GH   ++ +  ++  N
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 109 QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVT 168
            L S+S D+T ++W V  G+  +  +GH N V               C        L+V+
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVF--------------CCNFNPQSNLIVS 146

Query: 169 GSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL 228
           GS D + ++W V +G C +TL  H+  V  +  +  G    + S D   R WD  SG+ L
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206

Query: 229 RVFREHRG---SVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
           +   +      S +      + + + + D T+K W    G+C++T+T H+     +  + 
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266

Query: 286 GT-----LFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTAS----HDGA 336
                  + +GS D     ++ Q+ E+ +  +GHT ++     H      AS    +D  
Sbjct: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKT 326

Query: 337 LRLW 340
           ++LW
Sbjct: 327 IKLW 330



 Score = 99.0 bits (245), Expect = 6e-21
 Identities = 68/262 (25%), Positives = 122/262 (46%), Gaps = 28/262 (10%)

Query: 95  GHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLP 152
           GHT  V+ +  + N   L SSS D+  ++W    G+  +   GH+  +  +A+S+     
Sbjct: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD---- 98

Query: 153 STPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS 212
                       LLV+ S D T K+W V+SG C +TL+GH+  V C   +   +   +GS
Sbjct: 99  ----------SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148

Query: 213 TDATIRAWDILSGEQLRVFREHRGSVICLELVNR---LVYSGSADRTVKCWLADTGECVR 269
            D ++R WD+ +G+ L+    H   V  +   NR   L+ S S D   + W   +G+C++
Sbjct: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHF-NRDGSLIVSSSYDGLCRIWDTASGQCLK 207

Query: 270 T-FTAHRRNVSALKY--HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH-- 324
           T        VS +K+  +   +   + D   + +D   G+  + + GH     CI  +  
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267

Query: 325 ---GQVLYTASHDGALRLWDVR 343
              G+ + + S D  + +W+++
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQ 289



 Score = 72.0 bits (175), Expect = 8e-13
 Identities = 40/160 (25%), Positives = 77/160 (48%), Gaps = 6/160 (3%)

Query: 188 TLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV--ICLELVN 245
           TL GHT AV  +     G    + S D  I+ W    G+  +    H+  +  +     +
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99

Query: 246 RLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFDAQ 303
            L+ S S D+T+K W   +G+C++T   H   V    ++  +  + +GS D   R +D +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159

Query: 304 SGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWD 341
           +G+  +    H+  ++ +  +  G ++ ++S+DG  R+WD
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  110 bits (276), Expect = 2e-24
 Identities = 72/283 (25%), Positives = 125/283 (44%), Gaps = 24/283 (8%)

Query: 12  ADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF 71
           A H   ++ +  SP+G+ L + S D   ++W   DG+    + GH+  ++      ++  
Sbjct: 42  AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101

Query: 72  TCSA--DCTIRRWDVLTGQCLQVYRGHTSIV--NRILVANNQLFSSSYDRTARVWSVDKG 127
             SA  D T++ WDV +G+CL+  +GH++ V        +N + S S+D + R+W V  G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161

Query: 128 QMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQ 187
           +  +    H + V  + ++                G L+V+ S DG  ++W  ASG C +
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRD--------------GSLIVSSSYDGLCRIWDTASGQCLK 207

Query: 188 TLRGHTGAVLCLVLDTP-GHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL----- 241
           TL       +  V  +P G      + D T++ WD   G+ L+ +  H+    C+     
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267

Query: 242 ELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH 284
               + + SGS D  V  W   T E V+    H   V +   H
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310



 Score =  110 bits (276), Expect = 2e-24
 Identities = 73/270 (27%), Positives = 124/270 (45%), Gaps = 24/270 (8%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
           G   +  + H+ GI+ ++ S D   L++ S+D T ++W  + G+C   L+GH +YV  C 
Sbjct: 77  GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136

Query: 65  LEDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTAR 120
              ++    S   D ++R WDV TG+CL+    H+  V+ +      + + SSSYD   R
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196

Query: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV 180
           +W    GQ          C+ TL      D P     + +  G  ++  + D T K+W  
Sbjct: 197 IWDTASGQ----------CLKTLIDD---DNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243

Query: 181 ASGCCHQTLRGHTGAVLCLVLD---TPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGS 237
           + G C +T  GH     C+  +   T G    +GS D  +  W++ + E ++  + H   
Sbjct: 244 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303

Query: 238 VI---CLELVNRLVYSG-SADRTVKCWLAD 263
           VI   C    N +  +    D+T+K W +D
Sbjct: 304 VISTACHPTENIIASAALENDKTIKLWKSD 333



 Score =  101 bits (252), Expect = 1e-21
 Identities = 72/304 (23%), Positives = 131/304 (43%), Gaps = 30/304 (9%)

Query: 53  LQGHESYVTFCQLEDEAAF--TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVAN--N 108
           L GH   V+  +      +  + SAD  I+ W    G+  +   GH   ++ +  ++  N
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 109 QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVT 168
            L S+S D+T ++W V  G+  +  +GH N V               C        L+V+
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVF--------------CCNFNPQSNLIVS 146

Query: 169 GSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL 228
           GS D + ++W V +G C +TL  H+  V  +  +  G    + S D   R WD  SG+ L
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206

Query: 229 RVFREHRG---SVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
           +   +      S +      + + + + D T+K W    G+C++T+T H+     +  + 
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266

Query: 286 GT-----LFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTAS----HDGA 336
                  + +GS D     ++ Q+ E+ +  +GHT ++     H      AS    +D  
Sbjct: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKT 326

Query: 337 LRLW 340
           ++LW
Sbjct: 327 IKLW 330



 Score = 99.0 bits (245), Expect = 6e-21
 Identities = 68/262 (25%), Positives = 122/262 (46%), Gaps = 28/262 (10%)

Query: 95  GHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLP 152
           GHT  V+ +  + N   L SSS D+  ++W    G+  +   GH+  +  +A+S+     
Sbjct: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD---- 98

Query: 153 STPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS 212
                       LLV+ S D T K+W V+SG C +TL+GH+  V C   +   +   +GS
Sbjct: 99  ----------SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148

Query: 213 TDATIRAWDILSGEQLRVFREHRGSVICLELVNR---LVYSGSADRTVKCWLADTGECVR 269
            D ++R WD+ +G+ L+    H   V  +   NR   L+ S S D   + W   +G+C++
Sbjct: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHF-NRDGSLIVSSSYDGLCRIWDTASGQCLK 207

Query: 270 T-FTAHRRNVSALKY--HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH-- 324
           T        VS +K+  +   +   + D   + +D   G+  + + GH     CI  +  
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267

Query: 325 ---GQVLYTASHDGALRLWDVR 343
              G+ + + S D  + +W+++
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQ 289



 Score = 72.0 bits (175), Expect = 8e-13
 Identities = 40/160 (25%), Positives = 77/160 (48%), Gaps = 6/160 (3%)

Query: 188 TLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV--ICLELVN 245
           TL GHT AV  +     G    + S D  I+ W    G+  +    H+  +  +     +
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99

Query: 246 RLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFDAQ 303
            L+ S S D+T+K W   +G+C++T   H   V    ++  +  + +GS D   R +D +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159

Query: 304 SGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWD 341
           +G+  +    H+  ++ +  +  G ++ ++S+DG  R+WD
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score =  110 bits (276), Expect = 2e-24
 Identities = 73/222 (32%), Positives = 98/222 (44%), Gaps = 18/222 (8%)

Query: 6   SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL 65
           S L++   H G +   S SPD   LL+ SEDGT RLWS     C    +GH   V   Q 
Sbjct: 534 SELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQF 593

Query: 66  EDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARV 121
                +  S   D   R W     Q L+++ GH + VN  R    +N + + S DRT R+
Sbjct: 594 SPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRL 653

Query: 122 WSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181
           W V  G   R F GH+  + +L +S                G  L TG+TDG   +W + 
Sbjct: 654 WDVLNGNCVRIFTGHKGPIHSLTFSPN--------------GRFLATGATDGRVLLWDIG 699

Query: 182 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDIL 223
            G     L+GHT  V  L     G    +GS D T+R WD +
Sbjct: 700 HGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741



 Score = 92.8 bits (229), Expect = 4e-19
 Identities = 65/233 (27%), Positives = 92/233 (39%), Gaps = 20/233 (8%)

Query: 34  SEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSA--DCTIRRWDVLTGQCLQ 91
           S+D   R+          +L GH   V       +  +  S+  D T+R W + T  CL 
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 579

Query: 92  VYRGHTSIV--NRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPW 149
            Y+GH   V   +         S  +DR AR+W+ D  Q  R F GH             
Sbjct: 580 GYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGH------------- 626

Query: 150 DLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAF 209
            L    C         + TGS D T ++W V +G C +   GH G +  L     G    
Sbjct: 627 -LADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLA 685

Query: 210 TGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCW 260
           TG+TD  +  WDI  G  +   + H  +V  L       ++ SGS D TV+ W
Sbjct: 686 TGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 55/182 (30%), Positives = 84/182 (46%), Gaps = 6/182 (3%)

Query: 166 LVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSG 225
           L++ S DGT ++W + +  C    +GH   V        G+   +G  D   R W     
Sbjct: 558 LLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHY 617

Query: 226 EQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKY 283
           + LR+F  H   V C      +  V +GSADRTV+ W    G CVR FT H+  + +L +
Sbjct: 618 QPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTF 677

Query: 284 HAGTLF--TGSGDACARAFDAQSGELRRVFRGHTFIINCIQV--HGQVLYTASHDGALRL 339
                F  TG+ D     +D   G +    +GHT  +  ++    G++L + S D  +RL
Sbjct: 678 SPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRL 737

Query: 340 WD 341
           WD
Sbjct: 738 WD 739



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 64/260 (24%), Positives = 107/260 (41%), Gaps = 35/260 (13%)

Query: 90  LQVYRGHTSIVNRILVANNQLFSSSY-DRTARVWSVDKGQMSREFRGHRNCVLTLAYSAP 148
           L  Y+G T++    +  ++ L +  + D T RVWSV                       P
Sbjct: 467 LNAYQGLTAVD---VTDDSSLIAGGFADSTVRVWSV----------------------TP 501

Query: 149 WDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTA 208
             L S   A + +   L+   S D   ++    +    + L GH+G V         +  
Sbjct: 502 KKLRSVKQASDLS---LIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYL 558

Query: 209 FTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVY--SGSADRTVKCWLADTGE 266
            + S D T+R W + +   L  ++ H   V   +      Y  SG  DR  + W  D  +
Sbjct: 559 LSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQ 618

Query: 267 CVRTFTAHRRNVSALKYHAGTLF--TGSGDACARAFDAQSGELRRVFRGHTFIINCIQV- 323
            +R F  H  +V+  ++H  + +  TGS D   R +D  +G   R+F GH   I+ +   
Sbjct: 619 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 678

Query: 324 -HGQVLYTASHDGALRLWDV 342
            +G+ L T + DG + LWD+
Sbjct: 679 PNGRFLATGATDGRVLLWDI 698



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 30/85 (35%), Positives = 44/85 (51%), Gaps = 6/85 (7%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
           G+ +R+   H+G I+ L+ SP+G+ L TG+ DG   LW    G     L+GH    T C 
Sbjct: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD--TVCS 716

Query: 65  L----EDEAAFTCSADCTIRRWDVL 85
           L    + E   + S D T+R WD +
Sbjct: 717 LRFSRDGEILASGSMDNTVRLWDAI 741


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score =  108 bits (269), Expect = 1e-23
 Identities = 93/331 (28%), Positives = 141/331 (42%), Gaps = 44/331 (13%)

Query: 11  CADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADG-QCCALLQGHESYVTFCQLE--- 66
           C  HR  +  +S SPDG++L +G ++G   LW  + G Q    L GH  ++T    E   
Sbjct: 152 CKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLH 211

Query: 67  --DEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVNRI-LVANNQLFSSSYDRTARV 121
              E  +  S+  D ++R WD   G+C ++  GHT  V  +    +  L+S+S DRT +V
Sbjct: 212 ANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKV 271

Query: 122 WSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAA--------GGL-------- 165
           W    G + R  +GH + V T+A S  + L  T   E A A        G L        
Sbjct: 272 WRAHDGVLCRTLQGHGHWVNTMALSTDYAL-RTGAFEPAEASVNPQDLQGSLQELKERAL 330

Query: 166 -------------LVTGSTDGTAKVWQVASGCCHQT-LRGHTGAVLCLVLDTPGHTAFTG 211
                        LV+GS D T  +W  A      T + GH   +  ++         + 
Sbjct: 331 SRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASA 390

Query: 212 STDATIRAWDILSGEQLRVFREHRGSV--ICLELVNRLVYSGSADRTVKCWLADTGECVR 269
           S D +I+ WD  +G+ L   R H  +V  I     +RL+ SGS+D T+K W     +   
Sbjct: 391 SFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAM 450

Query: 270 TFTAHRRNVSALKY--HAGTLFTGSGDACAR 298
               H   V A+ +      + +G  D C R
Sbjct: 451 DLPGHADEVYAVDWSPDGQRVASGGKDKCLR 481



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 89/349 (25%), Positives = 149/349 (42%), Gaps = 36/349 (10%)

Query: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
           H   +  ++ SP G+ L +GS D T R W  +        +GH  +V       +     
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172

Query: 74  SA--DCTIRRWDVLTG-QCLQVYRGHTSIVNRI----LVANNQ---LFSSSYDRTARVWS 123
           S   +  I  WD  TG Q  +   GH+  +  +    L AN +   + SSS D + R+W 
Sbjct: 173 SGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232

Query: 124 VDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASG 183
              G+  R   GH   V  L +                  GLL + S D T KVW+   G
Sbjct: 233 TTAGRCERILTGHTQSVTCLRW---------------GGDGLLYSASQDRTIKVWRAHDG 277

Query: 184 CCHQTLRGHTGAVLCLVLDTPGHTAFTGS---TDATIRAWDIL-SGEQLRVFREHRGSVI 239
              +TL+GH   V  + L T  +   TG+    +A++   D+  S ++L+     R +++
Sbjct: 278 VLCRTLQGHGHWVNTMALST-DYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLV 336

Query: 240 CLELVNRLVYSGSADRTVKCWL-ADTGECVRTFTAHRRNVSALKYHAGTLFTGSG--DAC 296
             +   RLV SGS D T+  W  A+  + +   T H+  ++ + +   +    S   D  
Sbjct: 337 RGQGPERLV-SGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKS 395

Query: 297 ARAFDAQSGELRRVFRGHTFIINCI--QVHGQVLYTASHDGALRLWDVR 343
            + +D ++G+     RGH   +  I      ++L + S D  L++WDV+
Sbjct: 396 IKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 444



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 67/251 (26%), Positives = 102/251 (40%), Gaps = 33/251 (13%)

Query: 120 RVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQ 179
           RV +V +   S E  GH   V+++A+S                G  L +GS D T + W 
Sbjct: 99  RVRAVTRCTSSLE--GHSEAVISVAFSP--------------TGKYLASGSGDTTVRFWD 142

Query: 180 VASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL-RVFREHRGSV 238
           +++   H T +GH   VL +     G    +G  +  I  WD  +G+Q+ R    H   +
Sbjct: 143 LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWI 202

Query: 239 ICLELVN-------RLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA-GTLFT 290
             L           R V S S D +V+ W    G C R  T H ++V+ L++   G L++
Sbjct: 203 TGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYS 262

Query: 291 GSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPR 350
            S D   + + A  G L R  +GH   +N + +        S D ALR         +  
Sbjct: 263 ASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMAL--------STDYALRTGAFEPAEASVN 314

Query: 351 PPPPMRSLSRL 361
           P     SL  L
Sbjct: 315 PQDLQGSLQEL 325



 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 65/295 (22%), Positives = 117/295 (39%), Gaps = 66/295 (22%)

Query: 17  GINW--LSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLE-DEAAFTC 73
           G++W  L  +P+ + + + S+DG+ R+W T  G+C  +L GH   VT  +   D   ++ 
Sbjct: 204 GLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSA 263

Query: 74  SADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN------------------------- 108
           S D TI+ W    G   +  +GH   VN + ++ +                         
Sbjct: 264 SQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQ 323

Query: 109 -------------------QLFSSSYDRTARVWSV--DKGQMSREFRGHRNCVLTLAYSA 147
                              +L S S D T  +WS   DK  ++R   GH+  +  + +S 
Sbjct: 324 ELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTR-MTGHQALINQVLFSP 382

Query: 148 PWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHT 207
                            ++ + S D + K+W   +G    +LRGH  AV  +        
Sbjct: 383 D--------------SRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRL 428

Query: 208 AFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCW 260
             +GS+D+T++ WD+ + +       H   V  ++     + V SG  D+ ++ W
Sbjct: 429 LVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 30.4 bits (67), Expect = 2.7
 Identities = 20/83 (24%), Positives = 33/83 (39%), Gaps = 2/83 (2%)

Query: 2   GGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGH--ESY 59
           G  G  L     H   +  ++ S D + L++GS D T ++W     +    L GH  E Y
Sbjct: 401 GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVY 460

Query: 60  VTFCQLEDEAAFTCSADCTIRRW 82
                 + +   +   D  +R W
Sbjct: 461 AVDWSPDGQRVASGGKDKCLRIW 483


>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
           [Homo sapiens]
          Length = 514

 Score =  103 bits (256), Expect = 3e-22
 Identities = 74/261 (28%), Positives = 120/261 (45%), Gaps = 22/261 (8%)

Query: 52  LLQGHESYVTFCQLE--DEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ 109
           ++ GH  +V    +E  ++   T SAD TI+ WD+ +G+      GH S V  ++V+   
Sbjct: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRS 258

Query: 110 --LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLV 167
             LFS   D+  + W ++  ++ R + GH + V  L      D+              LV
Sbjct: 259 PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDV--------------LV 304

Query: 168 TGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ 227
           T S D TA++W V +     TL GHT AV  +          TGS D TIR WD+++G+ 
Sbjct: 305 TCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKT 364

Query: 228 LRVFREHRGSVICLELVNR--LVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
                 H+ SV  + L  R     SGS D  +K W    G  ++  + H   ++ L  ++
Sbjct: 365 RVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNS 423

Query: 286 -GTLFTGSGDACARAFDAQSG 305
            G L +G+ +     +D ++G
Sbjct: 424 DGVLVSGADNGTMHLWDWRTG 444



 Score = 98.6 bits (244), Expect = 8e-21
 Identities = 71/262 (27%), Positives = 113/262 (43%), Gaps = 20/262 (7%)

Query: 9   RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV--TFCQLE 66
           RV + H G +  +++ P  Q  +TGS D T ++W  A G+    L GH S V        
Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257

Query: 67  DEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTARVWSV 124
               F+C  D  ++ WD+   + ++ Y GH S V  + +    + L + S D TAR+W V
Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317

Query: 125 DKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC 184
                     GH N V T+                 AA   ++TGS D T ++W + +G 
Sbjct: 318 RTKASVHTLSGHTNAVATVRCQ--------------AAEPQIITGSHDTTIRLWDLVAGK 363

Query: 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEL- 243
              TL  H  +V  +VL  P H  F   +   I+ W    G  ++    H   +  L + 
Sbjct: 364 TRVTLTNHKKSVRAVVLH-PRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVN 422

Query: 244 VNRLVYSGSADRTVKCWLADTG 265
            + ++ SG+ + T+  W   TG
Sbjct: 423 SDGVLVSGADNGTMHLWDWRTG 444



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 48/164 (29%), Positives = 77/164 (46%), Gaps = 8/164 (4%)

Query: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV--ICLEL 243
           ++ + GH G V C+ ++       TGS D TI+ WD+ SG+       H  +V  + +  
Sbjct: 197 YRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVST 256

Query: 244 VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFD 301
            +  ++S   D+ VKCW  +  + +R +  H   V  L  H     L T S D+ AR +D
Sbjct: 257 RSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316

Query: 302 AQSGELRRVFRGHT---FIINCIQVHGQVLYTASHDGALRLWDV 342
            ++        GHT     + C     Q++ T SHD  +RLWD+
Sbjct: 317 VRTKASVHTLSGHTNAVATVRCQAAEPQII-TGSHDTTIRLWDL 359



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 38/121 (31%), Positives = 58/121 (47%), Gaps = 6/121 (4%)

Query: 229 RVFREHRGSVICL--ELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSAL--KYH 284
           RV   H G V C+  E  N+   +GSADRT+K W   +G+   + T H   V  +     
Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257

Query: 285 AGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHG--QVLYTASHDGALRLWDV 342
           +  LF+   D   + +D +  ++ R + GH   +  + +H    VL T S D   R+WDV
Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317

Query: 343 R 343
           R
Sbjct: 318 R 318



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 43/180 (23%), Positives = 71/180 (39%), Gaps = 16/180 (8%)

Query: 6   SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL 65
           +++   + H   +  +       +++TGS D T RLW    G+    L  H+  V    L
Sbjct: 321 ASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVL 380

Query: 66  ED-EAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDR-TARVWS 123
                 F   +   I++W    G  +Q   GH +I+N + V ++ +  S  D  T  +W 
Sbjct: 381 HPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLW- 439

Query: 124 VDKGQMSREFRGHRNCVLTLAYSAPWDLPST----PCAEEAAAGGLLVTGSTDGTAKVWQ 179
                   ++R   N     A   P  L S      CA + +   LL T   D T KV++
Sbjct: 440 --------DWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLL-TAEADKTIKVYR 490


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 80/325 (24%), Positives = 125/325 (38%), Gaps = 63/325 (19%)

Query: 18  INWLSLSPDGQRLLTGSEDGTARLWSTAD------------------------------- 46
           +N   +SPD + L  G ++   +LWS                                  
Sbjct: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDN 330

Query: 47  -GQCCALLQGH--ESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRI 103
            G    +L+GH    Y T    +     +CS D +IR WD+ +     +Y+GH   V  +
Sbjct: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL 390

Query: 104 LVANNQLF--SSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAA 161
            ++   L+  S S+DRTAR+WS D+    R + GH              L    C +   
Sbjct: 391 DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGH--------------LADVDCVKFHP 436

Query: 162 AGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 221
               L TGSTD T ++W    G   +   GH G VL L     G    +   D  ++ WD
Sbjct: 437 NSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD 496

Query: 222 ILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCW-----------LADTGECV 268
           + SG   +  R H  ++  L     + L+ S S D +V+ W              + E V
Sbjct: 497 LASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELV 556

Query: 269 RTFTAHRRNVSALKYHAGTLFTGSG 293
             +T    NV ++++ A  L   +G
Sbjct: 557 GVYTGQMSNVLSVQFMACNLLLVTG 581



 Score = 95.1 bits (235), Expect = 9e-20
 Identities = 65/222 (29%), Positives = 96/222 (43%), Gaps = 18/222 (8%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
           G+ +++   H G +       D   LL+ SED + R W         L QGH   V    
Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLD 391

Query: 65  LEDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTAR 120
           +   + +  S   D T R W       L++Y GH + V+  +    +N L + S D+T R
Sbjct: 392 ISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVR 451

Query: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV 180
           +WS  +G   R F GHR  VL+LA+S                G  L +   D   K+W +
Sbjct: 452 LWSAQQGNSVRLFTGHRGPVLSLAFS--------------PNGKYLASAGEDQRLKLWDL 497

Query: 181 ASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
           ASG  ++ LRGHT  +  L          + S D ++R WDI
Sbjct: 498 ASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 55/184 (29%), Positives = 84/184 (45%), Gaps = 6/184 (3%)

Query: 166 LVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSG 225
           L++ S D + + W + S       +GH   V  L +        +GS D T R W     
Sbjct: 357 LLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRT 416

Query: 226 EQLRVFREHRGSVICLELVNRLVY--SGSADRTVKCWLADTGECVRTFTAHRRNVSALKY 283
             LR++  H   V C++      Y  +GS D+TV+ W A  G  VR FT HR  V +L +
Sbjct: 417 YPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAF 476

Query: 284 HAGTLFTGSG--DACARAFDAQSGELRRVFRGHTFIINCIQVHGQ--VLYTASHDGALRL 339
                +  S   D   + +D  SG L +  RGHT  I  +       ++ +AS D ++R+
Sbjct: 477 SPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRV 536

Query: 340 WDVR 343
           WD+R
Sbjct: 537 WDIR 540



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 51/160 (31%), Positives = 75/160 (46%), Gaps = 6/160 (3%)

Query: 189 LRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLV 248
           LRGH G V             + S D +IR WD+ S     +++ H   V  L++    +
Sbjct: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSL 397

Query: 249 Y--SGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGT--LFTGSGDACARAFDAQS 304
           Y  SGS DRT + W  D    +R +  H  +V  +K+H  +  L TGS D   R + AQ 
Sbjct: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457

Query: 305 GELRRVFRGH--TFIINCIQVHGQVLYTASHDGALRLWDV 342
           G   R+F GH    +      +G+ L +A  D  L+LWD+
Sbjct: 458 GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDL 497



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 2/96 (2%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
           G+++R+   HRG +  L+ SP+G+ L +  ED   +LW  A G     L+GH   +T   
Sbjct: 458 GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLT 517

Query: 65  LEDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTS 98
              ++    SA  D ++R WD+    C     G +S
Sbjct: 518 FSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSS 553


>gi|18874090 WD repeat domain 48 [Homo sapiens]
          Length = 677

 Score = 95.5 bits (236), Expect = 7e-20
 Identities = 70/255 (27%), Positives = 112/255 (43%), Gaps = 14/255 (5%)

Query: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQ---CCALLQGHESYVTFCQL--EDE 68
           +R G+N L L P   RL T   D   R+WS    +     A ++ H  +V    L    +
Sbjct: 29  NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88

Query: 69  AAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWSVDK 126
              + S+D T++ W+   G C+   R H   V  +  A ++  + S+  DR   +W V+ 
Sbjct: 89  TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148

Query: 127 GQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCH 186
                      N V T + S   D   +    +   G ++V+GST+   +VW   +    
Sbjct: 149 ---LTALTASNNTVTTSSLSGNKDSIYSLAMNQL--GTIIVSGSTEKVLRVWDPRTCAKL 203

Query: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR 246
             L+GHT  V  L+L+  G    +GS+D TIR W +     +  +R H   V  L++ + 
Sbjct: 204 MKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDA 263

Query: 247 L--VYSGSADRTVKC 259
              VYSG  DR + C
Sbjct: 264 FTHVYSGGRDRKIYC 278



 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 83/348 (23%), Positives = 132/348 (37%), Gaps = 51/348 (14%)

Query: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
           H   +N + L  +G+ L++ S D T ++W+   G C + L+ H+ YV       +     
Sbjct: 74  HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVA 133

Query: 74  SA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILVAN---------NQL----FSSSYDRT 118
           SA  D  I  WDV T   L     + ++    L  N         NQL     S S ++ 
Sbjct: 134 SAGLDRQIFLWDVNTLTALTA--SNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKV 191

Query: 119 ARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVW 178
            RVW         + +GH + V  L  +       T C          ++GS+DGT ++W
Sbjct: 192 LRVWDPRTCAKLMKLKGHTDNVKALLLNRD----GTQC----------LSGSSDGTIRLW 237

Query: 179 QVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV 238
            +    C  T R H   V  L ++      ++G  D  I   D+ + +   +  E +  V
Sbjct: 238 SLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPV 297

Query: 239 ICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGD---A 295
           + +EL        SAD     W+A T   V  +T    +           F  SGD    
Sbjct: 298 LKMEL------DRSADPPPAIWVATTKSTVNKWTLKGIH----------NFRASGDYDND 341

Query: 296 CARAFDAQSGELRRVFRGHTFIINC-IQVHGQVLYTASHDGALRLWDV 342
           C         +  +V +G   II C I    + + T   +  +  WDV
Sbjct: 342 CTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDV 389


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 95.1 bits (235), Expect = 9e-20
 Identities = 64/217 (29%), Positives = 100/217 (46%), Gaps = 12/217 (5%)

Query: 161 AAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 220
           A+G LL TG  D    +W +    C  +L GHT  V  + L+TP      GS   +IR W
Sbjct: 31  ASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVW 90

Query: 221 DILSGEQLRVFREHRGSVICLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNV 278
           D+ + + LR    H+ ++  L+       V SGS D  +K W      CV  +  H + V
Sbjct: 91  DLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAV 150

Query: 279 SALKY--HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQ--VLYTASHD 334
             L++      L + + D   + +D  +G++   F GHT  +N ++ H    +L + S D
Sbjct: 151 RCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSD 210

Query: 335 GALRLWDVRGLRGA---PRPPPPMRSLSRLFSNKVGC 368
             +R WD+   +        P P+RS+  LF N  GC
Sbjct: 211 RTIRFWDLEKFQVVSCIEGEPGPVRSV--LF-NPDGC 244



 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 59/214 (27%), Positives = 87/214 (40%), Gaps = 19/214 (8%)

Query: 14  HRGGINWLSLSPDGQRLL-TGSEDGTARLWSTADGQCCALLQGHESYVTFCQLE--DEAA 70
           H   ++ L L     RLL TG +D    LWS     C   L GH S V   +L   +E  
Sbjct: 19  HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78

Query: 71  FTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLF--SSSYDRTARVWSVDKGQ 128
              S   +IR WD+   + L+   GH + +  +       F  S S D   ++W + +  
Sbjct: 79  VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138

Query: 129 MSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQT 188
               +RGH   V  L +S                G  L + + D T K+W + +G     
Sbjct: 139 CVFRYRGHSQAVRCLRFSPD--------------GKWLASAADDHTVKLWDLTAGKMMSE 184

Query: 189 LRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
             GHTG V  +      +   +GS+D TIR WD+
Sbjct: 185 FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218



 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 62/267 (23%), Positives = 108/267 (40%), Gaps = 20/267 (7%)

Query: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
           H   +  + L+   + ++ GS+ G+ R+W     +    L GH++ +          F  
Sbjct: 62  HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVA 121

Query: 74  SA--DCTIRRWDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARVWSVDKGQM 129
           S   D  I+ WD+    C+  YRGH+  V   R       L S++ D T ++W +  G+M
Sbjct: 122 SGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKM 181

Query: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTL 189
             EF GH   V  + +      P+           LL +GS+D T + W +        +
Sbjct: 182 MSEFPGHTGPVNVVEFH-----PNEY---------LLASGSSDRTIRFWDLEKFQVVSCI 227

Query: 190 RGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVN-RLV 248
            G  G V  ++ +  G   ++G  D ++R +         V   + G V  L + N +L+
Sbjct: 228 EGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERCFDVVLVNWGKVADLAICNDQLI 286

Query: 249 YSGSADRTVKCWLADTGECVRTFTAHR 275
               +   V  ++ D     RT T  R
Sbjct: 287 GVAFSQSNVSSYVVDLTRVTRTGTVAR 313



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 41/143 (28%), Positives = 66/143 (46%), Gaps = 4/143 (2%)

Query: 8   LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 67
           LR    H+  I  L   P G+ + +GS+D   +LW      C    +GH   V   +   
Sbjct: 98  LRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSP 157

Query: 68  EAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWS 123
           +  +  SA  D T++ WD+  G+ +  + GHT  VN +    N+  L S S DRT R W 
Sbjct: 158 DGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217

Query: 124 VDKGQMSREFRGHRNCVLTLAYS 146
           ++K Q+     G    V ++ ++
Sbjct: 218 LEKFQVVSCIEGEPGPVRSVLFN 240



 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 30/132 (22%), Positives = 60/132 (45%), Gaps = 7/132 (5%)

Query: 216 TIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHR 275
           T  AW +   +++     +  S++  +   RL+ +G  D  V  W  +   C+ + T H 
Sbjct: 7   TKTAWKL---QEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHT 63

Query: 276 RNVSALKYHA--GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTA 331
             V +++ +     +  GS     R +D ++ ++ R   GH   I  +  H  G+ + + 
Sbjct: 64  SPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASG 123

Query: 332 SHDGALRLWDVR 343
           S D  ++LWD+R
Sbjct: 124 SQDTNIKLWDIR 135


>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
           sapiens]
          Length = 340

 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 77/304 (25%), Positives = 124/304 (40%), Gaps = 35/304 (11%)

Query: 9   RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 68
           R    H   I  +  + D + L++ S+DG   +W +        +    S+V  C     
Sbjct: 49  RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108

Query: 69  AAFTCSAD----CTI-----RRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTA 119
             F         C+I     R  +V   + L  + G+ S      + +N + +SS D T 
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCR--FLDDNNIVTSSGDTTC 166

Query: 120 RVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQ 179
            +W ++ GQ    F GH    ++LA S  ++L               ++G+ D +AK+W 
Sbjct: 167 ALWDIETGQQKTVFVGHTGDCMSLAVSPDFNL--------------FISGACDASAKLWD 212

Query: 180 VASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
           V  G C QT  GH   +  +     G    TGS DA+ R +D+ + ++L  F     S+I
Sbjct: 213 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHE--SII 270

Query: 240 C------LELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAG--TLFTG 291
           C        L  RL+++G  D     W +   E V   + H   VS L   A    + TG
Sbjct: 271 CGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATG 330

Query: 292 SGDA 295
           S D+
Sbjct: 331 SWDS 334



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 73/312 (23%), Positives = 114/312 (36%), Gaps = 77/312 (24%)

Query: 85  LTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLA 144
           L G   ++Y  H +  +++LV      S+S D    VW               + V+T A
Sbjct: 51  LRGHLAKIYAMHWATDSKLLV------SASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCA 104

Query: 145 YSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASG----CCHQTLRGHTGAVLCL- 199
           Y              A +G  +  G  D    ++ + S        + L  HTG + C  
Sbjct: 105 Y--------------APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCR 150

Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVN--RLVYSGSADRTV 257
            LD   +   T S D T   WDI +G+Q  VF  H G  + L +     L  SG+ D + 
Sbjct: 151 FLDD--NNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASA 208

Query: 258 KCWLADTGECVRTFTAHRRNVSALKY--HAGTLFTGSGDACARAFDAQS----------- 304
           K W    G C +TFT H  +++A+ +  +   + TGS DA  R FD ++           
Sbjct: 209 KLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHES 268

Query: 305 ---------------------------------GELRRVFRGHTFIINCIQV--HGQVLY 329
                                             E   +  GH   ++C+ V   G  + 
Sbjct: 269 IICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVA 328

Query: 330 TASHDGALRLWD 341
           T S D  L++W+
Sbjct: 329 TGSWDSFLKIWN 340



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 50/202 (24%), Positives = 77/202 (38%), Gaps = 33/202 (16%)

Query: 53  LQGHESYVTFCQ-LEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVAN--NQ 109
           L  H  Y++ C+ L+D    T S D T   WD+ TGQ   V+ GHT     + V+   N 
Sbjct: 139 LSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNL 198

Query: 110 LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAA-------- 161
             S + D +A++W V +G   + F GH + +  + +    +   T   + +         
Sbjct: 199 FISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRAD 258

Query: 162 ----------------------AGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
                                 +G LL  G  D    VW          L GH   V CL
Sbjct: 259 QELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCL 318

Query: 200 VLDTPGHTAFTGSTDATIRAWD 221
            +   G    TGS D+ ++ W+
Sbjct: 319 GVTADGMAVATGSWDSFLKIWN 340



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 52/181 (28%), Positives = 73/181 (40%), Gaps = 22/181 (12%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV-TFC 63
           G    V   H G    L++SPD    ++G+ D +A+LW   +G C     GHES +   C
Sbjct: 174 GQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAIC 233

Query: 64  QLED-EAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRIL-----VANNQLFSSSYDR 117
              + EA  T S D + R +D+   Q L  +  H SI+  I      ++   LF+   D 
Sbjct: 234 FFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICGITSVAFSLSGRLLFAGYDDF 292

Query: 118 TARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKV 177
              VW   K +      GH N V               C    A G  + TGS D   K+
Sbjct: 293 NCNVWDSMKSERVGILSGHDNRV--------------SCLGVTADGMAVATGSWDSFLKI 338

Query: 178 W 178
           W
Sbjct: 339 W 339



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 37/166 (22%), Positives = 64/166 (38%), Gaps = 9/166 (5%)

Query: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV-- 244
           +TLRGH   +  +   T      + S D  +  WD  +  ++         V+       
Sbjct: 49  RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108

Query: 245 NRLVYSGSADRTVKCWLADTGE----CVRTFTAHRRNVSALKY-HAGTLFTGSGDACARA 299
              V  G  D     +   + E      R  +AH   +S  ++     + T SGD     
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCAL 168

Query: 300 FDAQSGELRRVFRGHTFIINCIQVHG--QVLYTASHDGALRLWDVR 343
           +D ++G+ + VF GHT     + V     +  + + D + +LWDVR
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214


>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
           sapiens]
          Length = 513

 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 72/288 (25%), Positives = 130/288 (45%), Gaps = 44/288 (15%)

Query: 24  SPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC---------- 73
           SPDGQ L+TGS DG   +W+   G+    L+ +++   F  ++D     C          
Sbjct: 223 SPDGQYLVTGSVDGFIEVWNFTTGKIRKDLK-YQAQDNFMMMDDAVLCMCFSRDTEMLAT 281

Query: 74  -SADCTIRRWDVLTGQCLQVY-RGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQM 129
            + D  I+ W + +GQCL+ + R H+  V  +  +  ++Q+ S+S+D+T R+  +  G+ 
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341

Query: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTL 189
            +EFRGH + V    ++                G  +++ S+DGT K+W + +  C  T 
Sbjct: 342 LKEFRGHSSFVNEATFTQD--------------GHYIISASSDGTVKIWNMKTTECSNTF 387

Query: 190 R--GHTGAV------LCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVF---REHRGSV 238
           +  G T         + L+   P H      ++  +     + G+ +R F   +   G  
Sbjct: 388 KSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIM--NMQGQIVRSFSSGKREGGDF 445

Query: 239 ICLELVNR--LVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH 284
           +C  L  R   +Y    D  + C+   TG+  RT T H ++V  + +H
Sbjct: 446 VCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHH 493



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 40/168 (23%), Positives = 74/168 (44%), Gaps = 15/168 (8%)

Query: 191 GHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLR----------VFREHRGSVIC 240
           G    V C      G    TGS D  I  W+  +G+  +          +  +     +C
Sbjct: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271

Query: 241 LELVNRLVYSGSADRTVKCWLADTGECVRTFT-AHRRNVSALKYH--AGTLFTGSGDACA 297
                 ++ +G+ D  +K W   +G+C+R F  AH + V+ L +   +  + + S D   
Sbjct: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331

Query: 298 RAFDAQSGELRRVFRGHTFIIN--CIQVHGQVLYTASHDGALRLWDVR 343
           R    +SG+  + FRGH+  +N       G  + +AS DG +++W+++
Sbjct: 332 RIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMK 379



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 27/98 (27%), Positives = 47/98 (47%), Gaps = 4/98 (4%)

Query: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV---TFCQLEDEAA 70
           H  G+  LS S D  ++L+ S D T R+     G+     +GH S+V   TF Q +    
Sbjct: 306 HSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQ-DGHYI 364

Query: 71  FTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN 108
            + S+D T++ W++ T +C   ++   S     +  N+
Sbjct: 365 ISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNS 402



 Score = 33.1 bits (74), Expect = 0.42
 Identities = 12/45 (26%), Positives = 23/45 (51%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQC 49
           G  L+    H   +N  + + DG  +++ S DGT ++W+    +C
Sbjct: 339 GKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTEC 383


>gi|34996489 pleckstrin homology domain interacting protein [Homo
           sapiens]
          Length = 1821

 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 85/350 (24%), Positives = 143/350 (40%), Gaps = 47/350 (13%)

Query: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
           H   +  ++    G+R+ TGS+D   ++W+T DG+  A L+GH + ++   +  E     
Sbjct: 182 HLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIA 241

Query: 74  SADCT--IRRWDVLTGQCLQVYRGHTSIVNRILVA------NNQLFSSSYDRTARVWSVD 125
           +  C   IR W + T   L V +GH++ +  +  +         L S+  D T   W  D
Sbjct: 242 AGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWD 301

Query: 126 KGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCC 185
            G +    R  +          P       C+  +A G  L TGSTD   +V+   SG  
Sbjct: 302 AGTLKINPRPAKFT------ERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQP 355

Query: 186 HQT--LRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEL 243
            +   L  HT  V  +      +   +GS D T R W          F+      I L++
Sbjct: 356 EKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQ---------FKRREWKSILLDM 406

Query: 244 VNRLV---YSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAF 300
             R       G  D+  K  +        T  A  R       H  T+ T   +   + +
Sbjct: 407 ATRPAGQNLQGIEDKITKMKV--------TMVAWDR-------HDNTVITAVNNMTLKVW 451

Query: 301 DAQSGELRRVFRGHTFIINCIQVHG---QVLYTASHDGALRLWDV-RGLR 346
           ++ +G+L  V  GH   +  ++ H    +VL++A HDG + +WD+ RG++
Sbjct: 452 NSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVK 501



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 41/175 (23%), Positives = 72/175 (41%), Gaps = 22/175 (12%)

Query: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV--ICLEL 243
           H+ + GH  +V C+  D  G   FTGS D  ++ W    G  L   R H   +  + +  
Sbjct: 176 HKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNY 235

Query: 244 VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGS----------G 293
            N ++ +GS D+ ++ W   T   +     H  ++++L++    L +GS          G
Sbjct: 236 ENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQF--SPLCSGSKRYLSSTGADG 293

Query: 294 DACARAFDAQSGEL--------RRVFRGHTFIINCIQVHGQVLYTASHDGALRLW 340
             C   +DA + ++         R   G   I +     G  L T S D  +R++
Sbjct: 294 TICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVY 348



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 68/305 (22%), Positives = 109/305 (35%), Gaps = 52/305 (17%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVT--- 61
           G  L     H   I+ ++++ +   +  GS D   R+W        A+LQGH + +T   
Sbjct: 215 GRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQ 274

Query: 62  ---FCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYR----------GHTSIVNRILVANN 108
               C        +  AD TI  W    G      R          G   I +       
Sbjct: 275 FSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGM 334

Query: 109 QLFSSSYDRTARVWSVDKGQMSR--EFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLL 166
            L + S D   RV+    GQ  +  E   H + V ++ +S                    
Sbjct: 335 FLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFS--------------NTSNRF 380

Query: 167 VTGSTDGTAKVWQ------------VASGCCHQTLRGHTG-----AVLCLVLDTPGHTAF 209
           V+GS DGTA++WQ            +A+    Q L+G         V  +  D   +T  
Sbjct: 381 VSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVI 440

Query: 210 TGSTDATIRAWDILSGEQLRVFREHRGSVICLE---LVNRLVYSGSADRTVKCWLADTGE 266
           T   + T++ W+  +G+ + V   H   V  LE      R+++S   D  V  W    G 
Sbjct: 441 TAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGV 500

Query: 267 CVRTF 271
            +R++
Sbjct: 501 KIRSY 505


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 72/287 (25%), Positives = 117/287 (40%), Gaps = 31/287 (10%)

Query: 9   RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 68
           R    H   I  +    D + L++ S+DG   +W +        +    S+V  C     
Sbjct: 49  RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108

Query: 69  AAFTCSAD----CTIRRWDVLTGQCLQVYR---GHTSIVNRI-LVANNQLFSSSYDRTAR 120
             +         C+I       G  ++V R   GHT  ++    + +NQ+ +SS D T  
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGN-VRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA 167

Query: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV 180
           +W ++ GQ +  F GH   V++L+ +     P T          L V+G+ D +AK+W V
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLA-----PDTR---------LFVSGACDASAKLWDV 213

Query: 181 ASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVIC 240
             G C QT  GH   +  +     G+   TGS DAT R +D+ + ++L  +     ++IC
Sbjct: 214 REGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY--SHDNIIC 271

Query: 241 ------LELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSAL 281
                      RL+ +G  D     W A   +       H   VS L
Sbjct: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCL 318



 Score = 82.0 bits (201), Expect = 8e-16
 Identities = 73/270 (27%), Positives = 108/270 (40%), Gaps = 35/270 (12%)

Query: 85  LTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLA 144
           L G   ++Y  H    +R+LV      S+S D    +W               + V+T A
Sbjct: 51  LRGHLAKIYAMHWGTDSRLLV------SASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCA 104

Query: 145 YSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASG----CCHQTLRGHTGAVLCL- 199
           Y+        P     A GGL      D    ++ + +        + L GHTG + C  
Sbjct: 105 YA--------PSGNYVACGGL------DNICSIYNLKTREGNVRVSRELAGHTGYLSCCR 150

Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTV 257
            LD   +   T S D T   WDI +G+Q   F  H G V+ L L    RL  SG+ D + 
Sbjct: 151 FLDD--NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASA 208

Query: 258 KCWLADTGECVRTFTAHRRNVSALKY--HAGTLFTGSGDACARAFDAQSGELRRVFRGHT 315
           K W    G C +TFT H  +++A+ +  +     TGS DA  R FD ++ +    +    
Sbjct: 209 KLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDN 268

Query: 316 FIINCIQV----HGQVLYTASHDGALRLWD 341
            I     V     G++L     D    +WD
Sbjct: 269 IICGITSVSFSKSGRLLLAGYDDFNCNVWD 298



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 60/235 (25%), Positives = 95/235 (40%), Gaps = 37/235 (15%)

Query: 24  SPDGQRLLTGSEDGTARLWS--TADG--QCCALLQGHESYVTFCQ-LEDEAAFTCSADCT 78
           +P G  +  G  D    +++  T +G  +    L GH  Y++ C+ L+D    T S D T
Sbjct: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT 165

Query: 79  IRRWDVLTGQCLQVYRGHTS-IVNRILVANNQLF-SSSYDRTARVWSVDKGQMSREFRGH 136
              WD+ TGQ    + GHT  +++  L  + +LF S + D +A++W V +G   + F GH
Sbjct: 166 CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH 225

Query: 137 RN----------------------CVL--------TLAYSAPWDLPSTPCAEEAAAGGLL 166
            +                      C L         + YS    +        + +G LL
Sbjct: 226 ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLL 285

Query: 167 VTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 221
           + G  D    VW          L GH   V CL +   G    TGS D+ ++ W+
Sbjct: 286 LAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 61/222 (27%), Positives = 92/222 (41%), Gaps = 23/222 (10%)

Query: 131 REFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLR 190
           R  RGH    L   Y+  W   S           LLV+ S DG   +W   +      + 
Sbjct: 49  RTLRGH----LAKIYAMHWGTDSR----------LLVSASQDGKLIIWDSYTTNKVHAIP 94

Query: 191 GHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGE-QLRVFRE---HRGSVICLELVN- 245
             +  V+       G+    G  D     +++ + E  +RV RE   H G + C   ++ 
Sbjct: 95  LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD 154

Query: 246 RLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGT--LFTGSGDACARAFDAQ 303
             + + S D T   W  +TG+   TFT H  +V +L     T    +G+ DA A+ +D +
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214

Query: 304 SGELRRVFRGHTFIIN--CIQVHGQVLYTASHDGALRLWDVR 343
            G  R+ F GH   IN  C   +G    T S D   RL+D+R
Sbjct: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 256



 Score = 34.7 bits (78), Expect = 0.14
 Identities = 30/131 (22%), Positives = 49/131 (37%), Gaps = 18/131 (13%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS----------TADGQCCALLQ 54
           G   +    H   IN +   P+G    TGS+D T RL+           + D   C +  
Sbjct: 216 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITS 275

Query: 55  GHESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN--QLFS 112
              S      L     F C+       WD L      V  GH + V+ + V ++   + +
Sbjct: 276 VSFSKSGRLLLAGYDDFNCNV------WDALKADRAGVLAGHDNRVSCLGVTDDGMAVAT 329

Query: 113 SSYDRTARVWS 123
            S+D   ++W+
Sbjct: 330 GSWDSFLKIWN 340


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 65/279 (23%), Positives = 112/279 (40%), Gaps = 29/279 (10%)

Query: 18  INWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV----------TFCQLED 67
           I++   SP+ + L T    G  +LWS  D      L+GH + V               +D
Sbjct: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293

Query: 68  EAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRIL--VANNQLFSSSYDRTARVWSVD 125
               +C+AD +++ W + + + +    GHT  V R++   +   L ++ YDR+ R+W ++
Sbjct: 294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353

Query: 126 KGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCC 185
             +      GH   V  +A+                 G L  TG  D   +VW + +G C
Sbjct: 354 AQEEILHQEGHSMGVYDIAFHQD--------------GSLAGTGGLDAFGRVWDLRTGRC 399

Query: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLE--- 242
              L GH   +  +     G+   TGS D T + WD+     +     H+  V  ++   
Sbjct: 400 IMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEP 459

Query: 243 LVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSAL 281
           +    + +G+ D T K W       ++T   H   V  L
Sbjct: 460 IHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGL 498



 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 55/200 (27%), Positives = 82/200 (41%), Gaps = 17/200 (8%)

Query: 25  PDGQRLLTGSEDGTARLWSTADGQCCALLQGHES--YVTFCQLEDEAAFTCSADCTIRRW 82
           P G+ L T   D + RLW     +     +GH    Y      +   A T   D   R W
Sbjct: 333 PSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVW 392

Query: 83  DVLTGQCLQVYRGHTSIVNRILVANN--QLFSSSYDRTARVWSVDKGQMSREFRGHRNCV 140
           D+ TG+C+    GH   +  I  + N   + + S D T +VW + + +       H+N V
Sbjct: 393 DLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLV 452

Query: 141 LTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLV 200
             + +             E   G  L+TG+ D TAK+W        +TL GH G V+ L 
Sbjct: 453 TGVKF-------------EPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLD 499

Query: 201 LDTPGHTAFTGSTDATIRAW 220
           + + G    T S D T + W
Sbjct: 500 ISSDGQLIATCSYDRTFKLW 519



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 45/170 (26%), Positives = 69/170 (40%), Gaps = 19/170 (11%)

Query: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGH--ESYVTFCQLEDEAAF 71
           H  G+  ++   DG    TG  D   R+W    G+C   L+GH  E Y            
Sbjct: 364 HSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIA 423

Query: 72  TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRIL---VANNQLFSSSYDRTARVWSVDKGQ 128
           T S D T + WD+   +C+     H ++V  +    +  N L + +YD TA++W+     
Sbjct: 424 TGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWS 483

Query: 129 MSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVW 178
             +   GH   V+ L  S+               G L+ T S D T K+W
Sbjct: 484 PLKTLAGHEGKVMGLDISSD--------------GQLIATCSYDRTFKLW 519



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 48/196 (24%), Positives = 77/196 (39%), Gaps = 14/196 (7%)

Query: 165 LLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLV--------LDTPGHTAFTGSTDAT 216
           +L T    G  K+W V       TLRGH   V  +V        LD       + + D +
Sbjct: 245 MLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGS 304

Query: 217 IRAWDILSGEQLRVFREH--RGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAH 274
           ++ W + S E +     H  R + +      R + +   DR+ + W  +  E +     H
Sbjct: 305 VKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGH 364

Query: 275 RRNVSALKYHAGTLFTGSG--DACARAFDAQSGELRRVFRGHTFIINCIQV--HGQVLYT 330
              V  + +H      G+G  DA  R +D ++G       GH   I  I    +G  + T
Sbjct: 365 SMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIAT 424

Query: 331 ASHDGALRLWDVRGLR 346
            S D   ++WD+R  R
Sbjct: 425 GSGDNTCKVWDLRQRR 440



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 32/126 (25%), Positives = 57/126 (45%), Gaps = 5/126 (3%)

Query: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVT--- 61
           G  +     H   I  ++ SP+G  + TGS D T ++W     +C   +  H++ VT   
Sbjct: 397 GRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVK 456

Query: 62  FCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHT-SIVNRILVANNQLFSS-SYDRTA 119
           F  +      T + D T + W       L+   GH   ++   + ++ QL ++ SYDRT 
Sbjct: 457 FEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTF 516

Query: 120 RVWSVD 125
           ++W  +
Sbjct: 517 KLWMAE 522



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 17/39 (43%), Positives = 22/39 (56%)

Query: 4   GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLW 42
           G S L+  A H G +  L +S DGQ + T S D T +LW
Sbjct: 481 GWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519


>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
          Length = 2627

 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 60/220 (27%), Positives = 88/220 (40%), Gaps = 23/220 (10%)

Query: 14   HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQG----HESYVTFCQ-LEDE 68
            H G ++  S S DG  L TG  D +   W     +   L+      H  +VT C   +D 
Sbjct: 2060 HEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDN 2119

Query: 69   AAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQ 128
               +CS+D ++  WD  +GQ L  + GH S V+ +      + S S D T +VW      
Sbjct: 2120 LLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWD----- 2174

Query: 129  MSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGG------LLVTGSTDGTAKVWQVAS 182
                   H+   LT   +    +     A E  A G      L+VT   DG  ++W    
Sbjct: 2175 -------HQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLL 2227

Query: 183  GCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
             C   TL GH+G V    +        T S D ++R W +
Sbjct: 2228 VCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQV 2267



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 90/389 (23%), Positives = 141/389 (36%), Gaps = 76/389 (19%)

Query: 18   INWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTF-------CQLEDEAA 70
            I  L+ +  G  +  G  D    LW+  +G   A    H  +V         CQL     
Sbjct: 1845 IRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQL----- 1899

Query: 71   FTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTA--------RVW 122
             T   D  ++ W    G+     RGH   ++ +  A +   S   DR A        R++
Sbjct: 1900 LTAGEDGKVQVWSGSLGRP----RGHLGSLS-LSPALSVALSPDGDRVAVGYRADGIRIY 1954

Query: 123  SVDKGQMSREFRGHRNCVLTLAYSAP--------------WDLPST-------------P 155
             +  G    + +     V  LA+ +P              W L                P
Sbjct: 1955 KISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKP 2014

Query: 156  CAEEAAAGGLLVTGSTDGTAKVW---------QVASGCCHQTLRGHTGAVLCLVLDTPGH 206
                A +  LL + S D T ++W         +     C   LRGH G V C    T G 
Sbjct: 2015 VLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGG 2074

Query: 207  TAFTGSTDATIRAWDILSGEQLRVFRE----HRGSVI-CLELVNRLVYSGSADRTVKCWL 261
            +  TG  D ++  WD+ + +   +       HR  V  C    + L+ S S+D +V  W 
Sbjct: 2075 SLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWD 2134

Query: 262  ADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCI 321
             ++G+ +  F  H+  VSA+      + + S D   + +D Q  EL  +      I +C 
Sbjct: 2135 PESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCA 2194

Query: 322  -----QVHGQ-----VLYTASHDGALRLW 340
                 +  GQ     ++ T   DGA RLW
Sbjct: 2195 AAMEPRAAGQPGSELLVVTVGLDGATRLW 2223



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 70/338 (20%), Positives = 125/338 (36%), Gaps = 36/338 (10%)

Query: 21   LSLSPDGQRLLTGSEDGTARLWSTADGQC-CALLQGHESYVTFCQLEDEAAFTCSADCTI 79
            ++ S +GQR   G+ +GT  L      Q   +++ G +       L D+  F  + D  +
Sbjct: 1682 VAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLL 1741

Query: 80   RRWDVLTG-QCLQVYRGHTSIVNRILVANNQLFSS-SYDRTARVWSVDKGQMSREFRGHR 137
              WD+  G + LQ       I    L  + +L ++       ++W   +GQ         
Sbjct: 1742 ELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ--------- 1792

Query: 138  NCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVL 197
               L   ++ P    S  C      G ++ TGS  G+   +QV      + L     ++ 
Sbjct: 1793 ---LAFQHTYP---KSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIR 1846

Query: 198  CLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV---ICLELVNRLVYSGSAD 254
             L  + PG     G  D+ +  W    G +L  F  H G V   + L    +L+ +G  D
Sbjct: 1847 TLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGE-D 1905

Query: 255  RTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRG- 313
              V+ W    G        H  ++S L        +  GD  A  + A    + ++  G 
Sbjct: 1906 GKVQVWSGSLGRP----RGHLGSLS-LSPALSVALSPDGDRVAVGYRADGIRIYKISSGS 1960

Query: 314  --------HTFIINCIQVHGQVLYTASHDGALRLWDVR 343
                       +     +  +VL + + DG+L+ W ++
Sbjct: 1961 QGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALK 1998



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 46/180 (25%), Positives = 75/180 (41%), Gaps = 10/180 (5%)

Query: 199  LVLDTPGHTAFTGSTDATIRAWDILSG-EQLRVFREHRGSVICLELVNRLVYSGSADRTV 257
            +   T G  A  G+ + T+   D+ +  E+  V     G   CL L +  ++  + D  +
Sbjct: 1682 VAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLL 1741

Query: 258  KCWLADTGECVRTFTAHRRNVSA--LKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHT 315
            + W    G  V    AH+  ++   L      L T     C + +D   G+L   F+ HT
Sbjct: 1742 ELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQL--AFQ-HT 1798

Query: 316  F--IINCIQVH--GQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSRLFSNKVGCAAA 371
            +   +NC+  H  GQV+ T S  G++  + V GL+       P  S+  L  N  G   A
Sbjct: 1799 YPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVA 1858


>gi|19913369 transducin beta-like 3 [Homo sapiens]
          Length = 808

 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 89/377 (23%), Positives = 146/377 (38%), Gaps = 56/377 (14%)

Query: 6   SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL 65
           S L V   H   +  L+ S DG  +L+   D    +W     Q    +   ES      L
Sbjct: 186 SCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLL 245

Query: 66  EDEAA------------FTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQ- 109
            +E               T     T+R W+  +GQC+       G    +    +A+   
Sbjct: 246 PEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAG 305

Query: 110 -LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVT 168
            + +++ D    ++     ++ ++F G+   VL + +  P D               +V 
Sbjct: 306 VVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPED-------------SHVVV 352

Query: 169 GSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL 228
            S     KV+++ +  C Q L GHT  VL L +   G    + + D ++R W +    Q+
Sbjct: 353 ASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQV 411

Query: 229 RVFREHR------GSVICLELVNRLVYSGSADRTVKCW-----------LADTG----EC 267
               +        G+V C  L    + +GS D TVK W             D G    + 
Sbjct: 412 MCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQA 471

Query: 268 VRTFTAHRRNVS--ALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH- 324
             T   H ++++  A+  +   L TGS D  A+ +     +L  VF GH   + C+Q   
Sbjct: 472 QTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSP 531

Query: 325 -GQVLYTASHDGALRLW 340
             QVL TAS DG ++LW
Sbjct: 532 MDQVLATASADGTIKLW 548



 Score = 85.1 bits (209), Expect = 9e-17
 Identities = 80/293 (27%), Positives = 120/293 (40%), Gaps = 28/293 (9%)

Query: 23  LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF--TCSADCTIR 80
           L P+   ++  S     +++       C +L GH   V    +  +     +C+ D ++R
Sbjct: 343 LGPEDSHVVVASNSPCLKVFELQTS-ACQILHGHTDIVLALDVFRKGWLFASCAKDQSVR 401

Query: 81  RWDV-LTGQ--CLQVYRGHTSIVNRILVANNQ---LFSSSYDRTARVWSVDKGQMSREFR 134
            W +   GQ  C+    GHT  V  +  +  +   L + S D T ++W + K  +S+   
Sbjct: 402 IWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTA 461

Query: 135 GHRNCVLTLAYSAPW----DLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLR 190
                +L  A +       D+ S   A       LL TGS D TAK+W +          
Sbjct: 462 PDNGPILLQAQTTQRCHDKDINSVAIAPNDK---LLATGSQDRTAKLWALPQCQLLGVFS 518

Query: 191 GHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR---L 247
           GH   + C+          T S D TI+ W +     L+ F  H  SV+ +  V+R   L
Sbjct: 519 GHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQL 578

Query: 248 VYSGSADRTVKCWLADTGECVRTFTAHRRNV-----SALKYHAGTLFTGSGDA 295
           + SGS D  VK W     ECVRT  AH   V     S L  HA    TG+ D+
Sbjct: 579 LSSGS-DGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHA---LTGASDS 627



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 69/280 (24%), Positives = 116/280 (41%), Gaps = 39/280 (13%)

Query: 6   SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLW---STADGQCCALLQGHESYV-T 61
           SA ++   H   +  L +   G    + ++D + R+W         C A   GH   V T
Sbjct: 367 SACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGT 426

Query: 62  FC--QLEDEAAFTCSADCTIRRWDV---------------LTGQCLQVYRGHTSIVNRIL 104
            C  +L++    T S DCT++ W +               +  Q     R H   +N + 
Sbjct: 427 VCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVA 486

Query: 105 VANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAA 162
           +A N   L + S DRTA++W++ + Q+   F GHR  +        W      C + +  
Sbjct: 487 IAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGL--------W------CVQFSPM 532

Query: 163 GGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
             +L T S DGT K+W +    C +T  GH  +VL +   + G    +  +D  ++ W I
Sbjct: 533 DQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTI 592

Query: 223 LSGEQLRVFREHRGSVICLEL--VNRLVYSGSADRTVKCW 260
            + E +R    H   V  L    ++    +G++D  V  W
Sbjct: 593 KNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 91/398 (22%), Positives = 150/398 (37%), Gaps = 90/398 (22%)

Query: 18  INWLSLSPDGQRLLTGSEDGTARLWSTADGQCC---ALLQGHESYVTFCQL--------- 65
           ++ L +   G   LT  + GT R+W  A GQC    A   G    +T C L         
Sbjct: 250 VSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLT 309

Query: 66  ------------------------------------EDEAAFTCSADCTIRRWDVLTGQC 89
                                               ED      S    ++ +++ T  C
Sbjct: 310 ATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC 369

Query: 90  LQVYRGHTSIVNRI-LVANNQLFSS-SYDRTARVWSVDK-GQMS--REFRGHRNCVLTLA 144
            Q+  GHT IV  + +     LF+S + D++ R+W ++K GQ+    +  GH + V T+ 
Sbjct: 370 -QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVC 428

Query: 145 YSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC---------------CHQTL 189
            S                   LVTGS D T K+W +                      T 
Sbjct: 429 CS-------------RLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQ 475

Query: 190 RGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEL--VNRL 247
           R H   +  + +        TGS D T + W +   + L VF  HR  + C++   ++++
Sbjct: 476 RCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQV 535

Query: 248 VYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKY-HAGTLFTGSG-DACARAFDAQSG 305
           + + SAD T+K W      C++TF  H  +V  + +   GT    SG D   + +  ++ 
Sbjct: 536 LATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNN 595

Query: 306 ELRRVFRGH---TFIINCIQVHGQVLYTASHDGALRLW 340
           E  R    H    + ++C ++    L T + D  + LW
Sbjct: 596 ECVRTLDAHEDKVWGLHCSRLDDHAL-TGASDSRVILW 632



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 86/362 (23%), Positives = 136/362 (37%), Gaps = 36/362 (9%)

Query: 5   GSALRVC-ADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFC 63
           GS  R+  A H   +  ++  P    L TG  DG  R+W           +G    V   
Sbjct: 98  GSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLV 157

Query: 64  QLEDEAA----FTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDR 117
               +      F+ + D  IR W +    CL V   H S V  +  +   + + SS  D+
Sbjct: 158 AFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDK 217

Query: 118 TARVWSVDKGQMSRE---FRGHRNCVLTLAYSAPWDLPSTPCAE--EAAAGGLLVTGSTD 172
              +W +   Q +R    F      VL         LP  P ++    + G   +T    
Sbjct: 218 ICIIWDLQSCQATRTVPVFESVEAAVL---------LPEEPVSQLGVKSPGLYFLTAGDQ 268

Query: 173 GTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTA---FTGSTDATIRAWDILSGEQLR 229
           GT +VW+ ASG C  T     G    L   T  HTA    T + D  +  ++  S    +
Sbjct: 269 GTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQK 328

Query: 230 VFREHRGSVICLELV---NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALK-YHA 285
            F  +   V+ +  +   +  V   S    +K +   T  C +    H   V AL  +  
Sbjct: 329 QFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRK 387

Query: 286 GTLFTG-SGDACARAFDA-QSGELRRVFR--GHTFIIN---CIQVHGQVLYTASHDGALR 338
           G LF   + D   R +   ++G++  V +  GHT  +    C ++    L T S D  ++
Sbjct: 388 GWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVK 447

Query: 339 LW 340
           LW
Sbjct: 448 LW 449



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 63/271 (23%), Positives = 106/271 (39%), Gaps = 34/271 (12%)

Query: 66  EDEAAFTCSADCTIRRWDVLTGQCLQVYRG-HTSIVNRILV--ANNQLFSSSYDRTARVW 122
           ++E   T S    + +W    G   ++++  HT+ V  +     +  L +   D   RVW
Sbjct: 77  DNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVW 136

Query: 123 SVDKGQMSREFRGHRNCVLTLAYSA-PWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181
            + +   +  FRG    V  +A+   P  L             LL + +TD   +VW + 
Sbjct: 137 DIVRHYGTHHFRGSPGVVHLVAFHPDPTRL-------------LLFSSATDAAIRVWSLQ 183

Query: 182 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLR---VFREHRGSV 238
              C   L  H  AV  L     GHT  +   D     WD+ S +  R   VF     +V
Sbjct: 184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAV 243

Query: 239 IC-LELVNRL--------VYSGSADRTVKCWLADTGECVRTFT-----AHRRNVSALKYH 284
           +   E V++L          +     T++ W A +G+CV T               L + 
Sbjct: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303

Query: 285 AGTLFTGSGDACARAFDAQSGELRRVFRGHT 315
           AG + T + D     ++A+S  L++ F G++
Sbjct: 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYS 334


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.135    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,281,250
Number of Sequences: 37866
Number of extensions: 773447
Number of successful extensions: 6064
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 228
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 2182
Number of HSP's gapped (non-prelim): 1697
length of query: 376
length of database: 18,247,518
effective HSP length: 104
effective length of query: 272
effective length of database: 14,309,454
effective search space: 3892171488
effective search space used: 3892171488
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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