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Search of human proteins with 157266266
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157266266 WD repeat domain 86 [Homo sapiens]
(376 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157266266 WD repeat domain 86 [Homo sapiens] 783 0.0
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 162 4e-40
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 162 4e-40
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 162 4e-40
gi|32189425 WD repeat domain 69 [Homo sapiens] 152 4e-37
gi|113865883 WD repeat domain 38 [Homo sapiens] 142 4e-34
gi|11968023 zinc finger protein 106 homolog [Homo sapiens] 126 4e-29
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 122 4e-28
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 122 4e-28
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 120 2e-27
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 120 2e-27
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 120 2e-27
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 115 5e-26
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] 115 5e-26
gi|23199987 WD repeat domain 5B [Homo sapiens] 114 1e-25
gi|16554629 WD repeat domain 5 [Homo sapiens] 110 2e-24
gi|16554627 WD repeat domain 5 [Homo sapiens] 110 2e-24
gi|21071067 TBP-associated factor 5 [Homo sapiens] 110 2e-24
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 108 1e-23
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 103 3e-22
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 97 2e-20
gi|18874090 WD repeat domain 48 [Homo sapiens] 96 7e-20
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 95 9e-20
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 95 1e-19
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 93 3e-19
gi|34996489 pleckstrin homology domain interacting protein [Homo... 90 4e-18
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 88 1e-17
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 88 1e-17
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 87 2e-17
gi|19913369 transducin beta-like 3 [Homo sapiens] 87 2e-17
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 783 bits (2021), Expect = 0.0
Identities = 376/376 (100%), Positives = 376/376 (100%)
Query: 1 MGGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV 60
MGGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV
Sbjct: 1 MGGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV 60
Query: 61 TFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTAR 120
TFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTAR
Sbjct: 61 TFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTAR 120
Query: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV 180
VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV
Sbjct: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV 180
Query: 181 ASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVIC 240
ASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVIC
Sbjct: 181 ASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVIC 240
Query: 241 LELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAF 300
LELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAF
Sbjct: 241 LELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAF 300
Query: 301 DAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSR 360
DAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSR
Sbjct: 301 DAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSR 360
Query: 361 LFSNKVGCAAAPLQPA 376
LFSNKVGCAAAPLQPA
Sbjct: 361 LFSNKVGCAAAPLQPA 376
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 162 bits (411), Expect = 4e-40
Identities = 91/286 (31%), Positives = 141/286 (49%), Gaps = 21/286 (7%)
Query: 27 GQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLT 86
G R+++GS+D T ++WS G+C L GH V Q+ D + S D T++ W+ T
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAET 332
Query: 87 GQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYS 146
G+C+ GHTS V + + ++ S S D T RVW ++ GQ GH V + Y
Sbjct: 333 GECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 392
Query: 147 APWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGH 206
G +V+G+ D KVW + C TL+GHT V L D G
Sbjct: 393 ----------------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GI 434
Query: 207 TAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGE 266
+GS D +IR WD+ +G + H+ +EL + ++ SG+AD TVK W TG+
Sbjct: 435 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ 494
Query: 267 CVRTF---TAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRR 309
C++T H+ V+ L+++ + T S D + +D ++GE R
Sbjct: 495 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 540
Score = 151 bits (381), Expect = 1e-36
Identities = 85/306 (27%), Positives = 146/306 (47%), Gaps = 22/306 (7%)
Query: 42 WSTADGQCCALLQGHESYVTFC-QLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIV 100
W + + +L+GH+ +V C Q + S D T++ W +TG+CL+ GHT V
Sbjct: 247 WRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 306
Query: 101 NRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEA 160
+ +N + S S DRT +VW+ + G+ GH + V +
Sbjct: 307 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------------ 354
Query: 161 AAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 220
+V+GS D T +VW + +G C L GH AV C+ D G +G+ D ++ W
Sbjct: 355 ----RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVW 408
Query: 221 DILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSA 280
D + L + H V L+ V SGS D +++ W +TG C+ T T H+ S
Sbjct: 409 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 468
Query: 281 LKYHAGTLFTGSGDACARAFDAQSGELRRVFRG---HTFIINCIQVHGQVLYTASHDGAL 337
++ L +G+ D+ + +D ++G+ + +G H + C+Q + + T+S DG +
Sbjct: 469 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 528
Query: 338 RLWDVR 343
+LWD++
Sbjct: 529 KLWDLK 534
Score = 87.0 bits (214), Expect = 2e-17
Identities = 50/182 (27%), Positives = 84/182 (46%), Gaps = 21/182 (11%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
G L V H + + DG+R+++G+ D ++W C LQGH + V Q
Sbjct: 373 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 430
Query: 65 LEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSV 124
+ + S D +IR WDV TG C+ GH S+ + + + +N L S + D T ++W +
Sbjct: 431 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 490
Query: 125 DKGQMSREFRG---HRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181
GQ + +G H++ V L ++ ++T S DGT K+W +
Sbjct: 491 KTGQCLQTLQGPNKHQSAVTCLQFNK----------------NFVITSSDDGTVKLWDLK 534
Query: 182 SG 183
+G
Sbjct: 535 TG 536
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 162 bits (411), Expect = 4e-40
Identities = 91/286 (31%), Positives = 141/286 (49%), Gaps = 21/286 (7%)
Query: 27 GQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLT 86
G R+++GS+D T ++WS G+C L GH V Q+ D + S D T++ W+ T
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAET 450
Query: 87 GQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYS 146
G+C+ GHTS V + + ++ S S D T RVW ++ GQ GH V + Y
Sbjct: 451 GECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 510
Query: 147 APWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGH 206
G +V+G+ D KVW + C TL+GHT V L D G
Sbjct: 511 ----------------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GI 552
Query: 207 TAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGE 266
+GS D +IR WD+ +G + H+ +EL + ++ SG+AD TVK W TG+
Sbjct: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ 612
Query: 267 CVRTF---TAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRR 309
C++T H+ V+ L+++ + T S D + +D ++GE R
Sbjct: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 658
Score = 151 bits (381), Expect = 1e-36
Identities = 85/306 (27%), Positives = 146/306 (47%), Gaps = 22/306 (7%)
Query: 42 WSTADGQCCALLQGHESYVTFC-QLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIV 100
W + + +L+GH+ +V C Q + S D T++ W +TG+CL+ GHT V
Sbjct: 365 WRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 424
Query: 101 NRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEA 160
+ +N + S S DRT +VW+ + G+ GH + V +
Sbjct: 425 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------------ 472
Query: 161 AAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 220
+V+GS D T +VW + +G C L GH AV C+ D G +G+ D ++ W
Sbjct: 473 ----RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVW 526
Query: 221 DILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSA 280
D + L + H V L+ V SGS D +++ W +TG C+ T T H+ S
Sbjct: 527 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586
Query: 281 LKYHAGTLFTGSGDACARAFDAQSGELRRVFRG---HTFIINCIQVHGQVLYTASHDGAL 337
++ L +G+ D+ + +D ++G+ + +G H + C+Q + + T+S DG +
Sbjct: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
Query: 338 RLWDVR 343
+LWD++
Sbjct: 647 KLWDLK 652
Score = 87.0 bits (214), Expect = 2e-17
Identities = 50/182 (27%), Positives = 84/182 (46%), Gaps = 21/182 (11%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
G L V H + + DG+R+++G+ D ++W C LQGH + V Q
Sbjct: 491 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 548
Query: 65 LEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSV 124
+ + S D +IR WDV TG C+ GH S+ + + + +N L S + D T ++W +
Sbjct: 549 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 608
Query: 125 DKGQMSREFRG---HRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181
GQ + +G H++ V L ++ ++T S DGT K+W +
Sbjct: 609 KTGQCLQTLQGPNKHQSAVTCLQFNK----------------NFVITSSDDGTVKLWDLK 652
Query: 182 SG 183
+G
Sbjct: 653 TG 654
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 162 bits (411), Expect = 4e-40
Identities = 91/286 (31%), Positives = 141/286 (49%), Gaps = 21/286 (7%)
Query: 27 GQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLT 86
G R+++GS+D T ++WS G+C L GH V Q+ D + S D T++ W+ T
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAET 370
Query: 87 GQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYS 146
G+C+ GHTS V + + ++ S S D T RVW ++ GQ GH V + Y
Sbjct: 371 GECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 430
Query: 147 APWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGH 206
G +V+G+ D KVW + C TL+GHT V L D G
Sbjct: 431 ----------------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GI 472
Query: 207 TAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGE 266
+GS D +IR WD+ +G + H+ +EL + ++ SG+AD TVK W TG+
Sbjct: 473 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ 532
Query: 267 CVRTF---TAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRR 309
C++T H+ V+ L+++ + T S D + +D ++GE R
Sbjct: 533 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 578
Score = 151 bits (381), Expect = 1e-36
Identities = 85/306 (27%), Positives = 146/306 (47%), Gaps = 22/306 (7%)
Query: 42 WSTADGQCCALLQGHESYVTFC-QLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIV 100
W + + +L+GH+ +V C Q + S D T++ W +TG+CL+ GHT V
Sbjct: 285 WRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 344
Query: 101 NRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEA 160
+ +N + S S DRT +VW+ + G+ GH + V +
Sbjct: 345 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------------ 392
Query: 161 AAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 220
+V+GS D T +VW + +G C L GH AV C+ D G +G+ D ++ W
Sbjct: 393 ----RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVW 446
Query: 221 DILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSA 280
D + L + H V L+ V SGS D +++ W +TG C+ T T H+ S
Sbjct: 447 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 506
Query: 281 LKYHAGTLFTGSGDACARAFDAQSGELRRVFRG---HTFIINCIQVHGQVLYTASHDGAL 337
++ L +G+ D+ + +D ++G+ + +G H + C+Q + + T+S DG +
Sbjct: 507 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 566
Query: 338 RLWDVR 343
+LWD++
Sbjct: 567 KLWDLK 572
Score = 87.0 bits (214), Expect = 2e-17
Identities = 50/182 (27%), Positives = 84/182 (46%), Gaps = 21/182 (11%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
G L V H + + DG+R+++G+ D ++W C LQGH + V Q
Sbjct: 411 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 468
Query: 65 LEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSV 124
+ + S D +IR WDV TG C+ GH S+ + + + +N L S + D T ++W +
Sbjct: 469 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 528
Query: 125 DKGQMSREFRG---HRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181
GQ + +G H++ V L ++ ++T S DGT K+W +
Sbjct: 529 KTGQCLQTLQGPNKHQSAVTCLQFNK----------------NFVITSSDDGTVKLWDLK 572
Query: 182 SG 183
+G
Sbjct: 573 TG 574
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 152 bits (385), Expect = 4e-37
Identities = 98/332 (29%), Positives = 156/332 (46%), Gaps = 27/332 (8%)
Query: 21 LSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV---TFCQLEDEAAFTCSADC 77
++L+ G +TGS D T +LW TA G+ L+GH + V F + T S D
Sbjct: 98 VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDK 157
Query: 78 TIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ---LFSSSYDRTARVWSVDKGQMSREFR 134
T + W V TG+C +RGHT+ + L N Q + + S D TA++W + G+ R
Sbjct: 158 TCKLWSVETGKCYHTFRGHTAEIV-CLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Query: 135 GHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTG 194
GH +++L+++ +G ++TGS D T VW +G L GH
Sbjct: 217 GHSAEIISLSFNT--------------SGDRIITGSFDHTVVVWDADTGRKVNILIGHCA 262
Query: 195 AVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI--CLELVNRLVYSGS 252
+ + TGS D T + WD +G+ + H ++ C + +L+ + S
Sbjct: 263 EISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATAS 322
Query: 253 ADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFDAQSGELRRV 310
AD T + + A T +C+ H +S + ++ L TGS D AR +DAQ+G+ +V
Sbjct: 323 ADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
Query: 311 FRGHT-FIINC-IQVHGQVLYTASHDGALRLW 340
GHT I +C G ++ T S D R+W
Sbjct: 383 LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 117 bits (292), Expect = 2e-26
Identities = 77/291 (26%), Positives = 124/291 (42%), Gaps = 35/291 (12%)
Query: 5 GSALRVCADHRGGINWLSLS-PDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFC 63
G L HR + ++ + P G ++ TGS D T +LWS G+C +GH + +
Sbjct: 124 GEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCL 183
Query: 64 QLEDEAAF--TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRIL--VANNQLFSSSYDRTA 119
++ T S D T + WD+ G+ + RGH++ + + + +++ + S+D T
Sbjct: 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTV 243
Query: 120 RVWSVDKGQMSREFRGHR----------NCVLTLAYSAP-----WDLPSTPCAEEAAA-- 162
VW D G+ GH +C L L S WD + C
Sbjct: 244 VVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHD 303
Query: 163 -----------GGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTG 211
G L+ T S DGTA+++ A+ C L GH G + + + G+ TG
Sbjct: 304 DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTG 363
Query: 212 STDATIRAWDILSGEQLRVFREHRGSVI--CLELVNRLVYSGSADRTVKCW 260
S+D T R WD +G+ L+V H + +V +GS D T + W
Sbjct: 364 SSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 97.8 bits (242), Expect = 1e-20
Identities = 60/187 (32%), Positives = 86/187 (45%), Gaps = 7/187 (3%)
Query: 162 AGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTP-GHTAFTGSTDATIRAW 220
+G +TGS D T K+W ASG TL GH V + + P G TGS D T + W
Sbjct: 103 SGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162
Query: 221 DILSGEQLRVFREHRGSVICLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNV 278
+ +G+ FR H ++CL + LV +GS D T K W GE V T H +
Sbjct: 163 SVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEI 222
Query: 279 SALKYHAG--TLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHG--QVLYTASHD 334
+L ++ + TGS D +DA +G + GH I+ + ++ T S D
Sbjct: 223 ISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMD 282
Query: 335 GALRLWD 341
+LWD
Sbjct: 283 KTCKLWD 289
Score = 85.9 bits (211), Expect = 5e-17
Identities = 50/179 (27%), Positives = 83/179 (46%), Gaps = 18/179 (10%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV--TF 62
G + + H I+ S + D +LTGS D T +LW +G+C A L GH+ + +
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310
Query: 63 CQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTAR 120
+ T SAD T R + T +C+ GH +++I N L + S D+TAR
Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370
Query: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQ 179
+W GQ + GH + + + A++ G +++TGS D T ++W+
Sbjct: 371 IWDAQTGQCLQVLEGHTDEIFSCAFNYK--------------GNIVITGSKDNTCRIWR 415
Score = 85.1 bits (209), Expect = 9e-17
Identities = 51/162 (31%), Positives = 76/162 (46%), Gaps = 7/162 (4%)
Query: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR 246
+ L+ H + + L+ G TGS D T + WD SGE+L HR V + N
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 247 L---VYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFD 301
+ +GS D+T K W +TG+C TF H + L ++ + + TGS D A+ +D
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Query: 302 AQSGELRRVFRGHT--FIINCIQVHGQVLYTASHDGALRLWD 341
Q+GE RGH+ I G + T S D + +WD
Sbjct: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 142 bits (359), Expect = 4e-34
Identities = 93/266 (34%), Positives = 124/266 (46%), Gaps = 24/266 (9%)
Query: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
H G +N + SPDGQ LLTGSEDG W T GQ L GH V FC+ +
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 74 SA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQM 129
SA DCT+R WDV +CL+V +GH V + + + QL S +D+ +W V GQM
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVW---QVASGCCH 186
R GHR+ + + +S P+ C L TGS D T +W V H
Sbjct: 140 LRLLVGHRDSIQSSDFS-----PTVNC---------LATGSWDSTVHIWDLRMVTPAVSH 185
Query: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR 246
Q L GH+ + CL G A +GS D TI W + L + H V +
Sbjct: 186 QALEGHSANISCLCYSASGLLA-SGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244
Query: 247 LVYSGSA--DRTVKCWLADTGECVRT 270
++ SA R VK W +TG+C+ T
Sbjct: 245 ELWLASAGYSRMVKVWDCNTGKCLET 270
Score = 80.9 bits (198), Expect = 2e-15
Identities = 64/261 (24%), Positives = 101/261 (38%), Gaps = 24/261 (9%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
G L H G + + SPDG + S D T RLW A +C +L+GH+ V
Sbjct: 53 GQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVS 112
Query: 65 LEDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIV--NRILVANNQLFSSSYDRTAR 120
++ S D + WDV +GQ L++ GH + + N L + S+D T
Sbjct: 113 FSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVH 172
Query: 121 VWS---VDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKV 177
+W V + GH + L YS A GLL +GS D T +
Sbjct: 173 IWDLRMVTPAVSHQALEGHSANISCLCYS---------------ASGLLASGSWDKTIHI 217
Query: 178 WQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFRE--HR 235
W+ + L+GH V + + ++ WD +G+ L +
Sbjct: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277
Query: 236 GSVICLELVNRLVYSGSADRT 256
+++ SG+AD+T
Sbjct: 278 AHTCAFTPDGKILVSGAADQT 298
Score = 65.9 bits (159), Expect = 6e-11
Identities = 46/158 (29%), Positives = 65/158 (41%), Gaps = 6/158 (3%)
Query: 192 HTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVY 249
H G V G TGS D + W+ SG+ L H G V L
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 250 SGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGT--LFTGSGDACARAFDAQSGEL 307
S S D TV+ W +C+R H+R+V + + + L +G D +D QSG++
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 308 RRVFRGHTFIINCIQVHGQV--LYTASHDGALRLWDVR 343
R+ GH I V L T S D + +WD+R
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177
>gi|11968023 zinc finger protein 106 homolog [Homo sapiens]
Length = 1883
Score = 126 bits (316), Expect = 4e-29
Identities = 85/293 (29%), Positives = 140/293 (47%), Gaps = 25/293 (8%)
Query: 54 QGHESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVA-----NN 108
+GH++ V Q+ +TCSAD T+R +++++ +C+ V+ GHTS VN +LV N
Sbjct: 1528 EGHQAAVNAIQIFGNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKNA 1587
Query: 109 QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVT 168
L++ S D T R ++V R CV L C + +L
Sbjct: 1588 ALYTGSSDHTIRCYNVKS----------RECVEQLQLE-----DRVLCLH--SRWRILYA 1630
Query: 169 GSTDGTAKVWQVASGCCHQTLRGH-TGAVLCLVLDTPG--HTAFTGSTDATIRAWDILSG 225
G +GT + + + + H AV CL G GS D TI D +G
Sbjct: 1631 GLANGTVVTFNIKNNKRLEIFECHGPRAVSCLATAQEGARKLLVVGSYDCTISVRDARNG 1690
Query: 226 EQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
LR H +++C+++VN LV+SGS+D++V TGE VR + H V+ +
Sbjct: 1691 LLLRTLEGHSKTILCMKVVNDLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNILG 1750
Query: 286 GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALR 338
+ T D R ++ QS + +V+ GH +I C+ +H ++YT +DG+++
Sbjct: 1751 KVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKSMIYTGCYDGSIQ 1803
Score = 54.7 bits (130), Expect = 1e-07
Identities = 26/128 (20%), Positives = 66/128 (51%), Gaps = 2/128 (1%)
Query: 18 INWLSLSPDGQR--LLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSA 75
++ L+ + +G R L+ GS D T + +G L+GH + ++ ++ F+ S+
Sbjct: 1659 VSCLATAQEGARKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVNDLVFSGSS 1718
Query: 76 DCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRG 135
D ++ ++ TG+ +++Y+GH V + + + ++ D+ RV+ + + + G
Sbjct: 1719 DQSVHAHNIHTGELVRIYKGHNHAVTVVNILGKVMVTACLDKFVRVYELQSHDRLQVYGG 1778
Query: 136 HRNCVLTL 143
H++ ++ +
Sbjct: 1779 HKDMIMCM 1786
Score = 45.8 bits (107), Expect = 6e-05
Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 5/79 (6%)
Query: 270 TFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQV-----H 324
+F H+ V+A++ L+T S D R ++ S + VF GHT +NC+ V
Sbjct: 1526 SFEGHQAAVNAIQIFGNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGK 1585
Query: 325 GQVLYTASHDGALRLWDVR 343
LYT S D +R ++V+
Sbjct: 1586 NAALYTGSSDHTIRCYNVK 1604
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 122 bits (307), Expect = 4e-28
Identities = 98/344 (28%), Positives = 143/344 (41%), Gaps = 54/344 (15%)
Query: 23 LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82
L D Q++++G D T ++W +C +L GH V Q ++ T S+D T+R W
Sbjct: 273 LQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVW 332
Query: 83 DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139
DV TG+ L H V + N + + S DR+ VW + + R GHR
Sbjct: 333 DVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 392
Query: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
V + + + +V+ S D T KVW ++ +TL GH + C
Sbjct: 393 VNVVDFDDKY----------------IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIAC- 435
Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259
L +GS+D TIR WDI G LRV H V C+ N+ + SG+ D +K
Sbjct: 436 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 494
Query: 260 WLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIIN 319
W V+AL A +G C R SG RVFR
Sbjct: 495 W---------------DLVAALDPRA-----PAGTLCLRTLVEHSG---RVFR------- 524
Query: 320 CIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSRLFS 363
+Q + ++SHD + +WD A PP RS SR ++
Sbjct: 525 -LQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPP--RSPSRTYT 565
Score = 108 bits (271), Expect = 6e-24
Identities = 73/264 (27%), Positives = 114/264 (43%), Gaps = 32/264 (12%)
Query: 9 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 68
R+ H G + L L D + ++TGS D T R+W G+ L H V + +
Sbjct: 301 RILTGHTGSV--LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG 358
Query: 69 AAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSVD 125
TCS D +I WD+ + + + R GH + VN + + + S+S DRT +VW+
Sbjct: 359 MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTS 418
Query: 126 KGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCC 185
+ R GH+ + L Y L+V+GS+D T ++W + G C
Sbjct: 419 TCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGAC 462
Query: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHRG 236
+ L GH V C+ D +G+ D I+ WD+++ LR EH G
Sbjct: 463 LRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSG 520
Query: 237 SVICLELVNRLVYSGSADRTVKCW 260
V L+ + S S D T+ W
Sbjct: 521 RVFRLQFDEFQIVSSSHDDTILIW 544
Score = 67.8 bits (164), Expect = 2e-11
Identities = 32/105 (30%), Positives = 55/105 (52%)
Query: 238 VICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACA 297
V CL+ ++ + SG D T+K W +T EC R T H +V L+Y + TGS D+
Sbjct: 270 VYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTV 329
Query: 298 RAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342
R +D +GE+ H + ++ + ++ T S D ++ +WD+
Sbjct: 330 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDM 374
Score = 45.8 bits (107), Expect = 6e-05
Identities = 21/67 (31%), Positives = 36/67 (53%)
Query: 276 RNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDG 335
+ V L+Y + +G D + +D + E +R+ GHT + C+Q +V+ T S D
Sbjct: 268 KGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDS 327
Query: 336 ALRLWDV 342
+R+WDV
Sbjct: 328 TVRVWDV 334
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 122 bits (307), Expect = 4e-28
Identities = 98/344 (28%), Positives = 143/344 (41%), Gaps = 54/344 (15%)
Query: 23 LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82
L D Q++++G D T ++W +C +L GH V Q ++ T S+D T+R W
Sbjct: 309 LQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVW 368
Query: 83 DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139
DV TG+ L H V + N + + S DR+ VW + + R GHR
Sbjct: 369 DVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 428
Query: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
V + + + +V+ S D T KVW ++ +TL GH + C
Sbjct: 429 VNVVDFDDKY----------------IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIAC- 471
Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259
L +GS+D TIR WDI G LRV H V C+ N+ + SG+ D +K
Sbjct: 472 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 530
Query: 260 WLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIIN 319
W V+AL A +G C R SG RVFR
Sbjct: 531 W---------------DLVAALDPRA-----PAGTLCLRTLVEHSG---RVFR------- 560
Query: 320 CIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSRLFS 363
+Q + ++SHD + +WD A PP RS SR ++
Sbjct: 561 -LQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPP--RSPSRTYT 601
Score = 108 bits (271), Expect = 6e-24
Identities = 73/264 (27%), Positives = 114/264 (43%), Gaps = 32/264 (12%)
Query: 9 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 68
R+ H G + L L D + ++TGS D T R+W G+ L H V + +
Sbjct: 337 RILTGHTGSV--LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG 394
Query: 69 AAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSVD 125
TCS D +I WD+ + + + R GH + VN + + + S+S DRT +VW+
Sbjct: 395 MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTS 454
Query: 126 KGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCC 185
+ R GH+ + L Y L+V+GS+D T ++W + G C
Sbjct: 455 TCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGAC 498
Query: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHRG 236
+ L GH V C+ D +G+ D I+ WD+++ LR EH G
Sbjct: 499 LRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSG 556
Query: 237 SVICLELVNRLVYSGSADRTVKCW 260
V L+ + S S D T+ W
Sbjct: 557 RVFRLQFDEFQIVSSSHDDTILIW 580
Score = 67.8 bits (164), Expect = 2e-11
Identities = 32/105 (30%), Positives = 55/105 (52%)
Query: 238 VICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACA 297
V CL+ ++ + SG D T+K W +T EC R T H +V L+Y + TGS D+
Sbjct: 306 VYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTV 365
Query: 298 RAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342
R +D +GE+ H + ++ + ++ T S D ++ +WD+
Sbjct: 366 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDM 410
Score = 45.8 bits (107), Expect = 6e-05
Identities = 21/67 (31%), Positives = 36/67 (53%)
Query: 276 RNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDG 335
+ V L+Y + +G D + +D + E +R+ GHT + C+Q +V+ T S D
Sbjct: 304 KGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDS 363
Query: 336 ALRLWDV 342
+R+WDV
Sbjct: 364 TVRVWDV 370
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 120 bits (301), Expect = 2e-27
Identities = 73/249 (29%), Positives = 117/249 (46%), Gaps = 22/249 (8%)
Query: 107 NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLL 166
+ ++ S D + ++W + + GH VL L Y ++
Sbjct: 250 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER----------------VI 293
Query: 167 VTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGE 226
VTGS+D T +VW V +G TL H AVL L T S D +I WD+ S
Sbjct: 294 VTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAVWDMASAT 351
Query: 227 QL---RVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKY 283
+ RV HR +V ++ ++ + S S DRT+K W T E VRT H+R ++ L+Y
Sbjct: 352 DITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY 411
Query: 284 HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVR 343
+ +GS D R +D + G RV GH ++ CI+ + + + ++DG +++WD++
Sbjct: 412 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQ 471
Query: 344 GLRGAPRPP 352
PR P
Sbjct: 472 AALD-PRAP 479
Score = 119 bits (299), Expect = 3e-27
Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 36/313 (11%)
Query: 23 LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82
L D +++++G D + ++W +C +L GH V Q ++ T S+D T+R W
Sbjct: 246 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVW 305
Query: 83 DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139
DV TG+ L H V + +N + + S DR+ VW + + R GHR
Sbjct: 306 DVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 365
Query: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
V + + + +V+ S D T KVW ++ +TL GH + C
Sbjct: 366 VNVVDFDDKY----------------IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIAC- 408
Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259
L +GS+D TIR WDI G LRV H V C+ N+ + SG+ D +K
Sbjct: 409 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 467
Query: 260 W---------LADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFD------AQS 304
W + C+RT H V L++ + + S D +D +
Sbjct: 468 WDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQ 527
Query: 305 GELRRVFRGHTFI 317
E R R +T+I
Sbjct: 528 NETRSPSRTYTYI 540
Score = 111 bits (278), Expect = 9e-25
Identities = 75/265 (28%), Positives = 114/265 (43%), Gaps = 32/265 (12%)
Query: 8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 67
L+V H G + L L D + ++TGS D T R+W G+ L H V + +
Sbjct: 273 LKVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 330
Query: 68 EAAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSV 124
TCS D +I WD+ + + + R GH + VN + + + S+S DRT +VWS
Sbjct: 331 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 390
Query: 125 DKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC 184
+ R GH+ + L Y L+V+GS+D T ++W + G
Sbjct: 391 STCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGA 434
Query: 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHR 235
C + L GH V C+ D +G+ D I+ WD+ + LR EH
Sbjct: 435 CLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS 492
Query: 236 GSVICLELVNRLVYSGSADRTVKCW 260
G V L+ + S S D T+ W
Sbjct: 493 GRVFRLQFDEFQIISSSHDDTILIW 517
Score = 64.3 bits (155), Expect = 2e-10
Identities = 30/117 (25%), Positives = 59/117 (50%)
Query: 226 EQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
++++ E+ V CL+ + + SG D ++K W + EC++ T H +V L+Y
Sbjct: 231 QRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE 290
Query: 286 GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342
+ TGS D+ R +D +GE+ H + ++ ++ T S D ++ +WD+
Sbjct: 291 RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDM 347
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 120 bits (301), Expect = 2e-27
Identities = 73/249 (29%), Positives = 117/249 (46%), Gaps = 22/249 (8%)
Query: 107 NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLL 166
+ ++ S D + ++W + + GH VL L Y ++
Sbjct: 216 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER----------------VI 259
Query: 167 VTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGE 226
VTGS+D T +VW V +G TL H AVL L T S D +I WD+ S
Sbjct: 260 VTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAVWDMASAT 317
Query: 227 QL---RVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKY 283
+ RV HR +V ++ ++ + S S DRT+K W T E VRT H+R ++ L+Y
Sbjct: 318 DITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY 377
Query: 284 HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVR 343
+ +GS D R +D + G RV GH ++ CI+ + + + ++DG +++WD++
Sbjct: 378 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQ 437
Query: 344 GLRGAPRPP 352
PR P
Sbjct: 438 AALD-PRAP 445
Score = 119 bits (299), Expect = 3e-27
Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 36/313 (11%)
Query: 23 LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82
L D +++++G D + ++W +C +L GH V Q ++ T S+D T+R W
Sbjct: 212 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVW 271
Query: 83 DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139
DV TG+ L H V + +N + + S DR+ VW + + R GHR
Sbjct: 272 DVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 331
Query: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
V + + + +V+ S D T KVW ++ +TL GH + C
Sbjct: 332 VNVVDFDDKY----------------IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIAC- 374
Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259
L +GS+D TIR WDI G LRV H V C+ N+ + SG+ D +K
Sbjct: 375 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 433
Query: 260 W---------LADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFD------AQS 304
W + C+RT H V L++ + + S D +D +
Sbjct: 434 WDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQ 493
Query: 305 GELRRVFRGHTFI 317
E R R +T+I
Sbjct: 494 NETRSPSRTYTYI 506
Score = 111 bits (278), Expect = 9e-25
Identities = 75/265 (28%), Positives = 114/265 (43%), Gaps = 32/265 (12%)
Query: 8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 67
L+V H G + L L D + ++TGS D T R+W G+ L H V + +
Sbjct: 239 LKVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 296
Query: 68 EAAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSV 124
TCS D +I WD+ + + + R GH + VN + + + S+S DRT +VWS
Sbjct: 297 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 356
Query: 125 DKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC 184
+ R GH+ + L Y L+V+GS+D T ++W + G
Sbjct: 357 STCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGA 400
Query: 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHR 235
C + L GH V C+ D +G+ D I+ WD+ + LR EH
Sbjct: 401 CLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS 458
Query: 236 GSVICLELVNRLVYSGSADRTVKCW 260
G V L+ + S S D T+ W
Sbjct: 459 GRVFRLQFDEFQIISSSHDDTILIW 483
Score = 64.3 bits (155), Expect = 2e-10
Identities = 30/117 (25%), Positives = 59/117 (50%)
Query: 226 EQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
++++ E+ V CL+ + + SG D ++K W + EC++ T H +V L+Y
Sbjct: 197 QRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE 256
Query: 286 GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342
+ TGS D+ R +D +GE+ H + ++ ++ T S D ++ +WD+
Sbjct: 257 RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDM 313
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 120 bits (301), Expect = 2e-27
Identities = 73/249 (29%), Positives = 117/249 (46%), Gaps = 22/249 (8%)
Query: 107 NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLL 166
+ ++ S D + ++W + + GH VL L Y ++
Sbjct: 237 DEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER----------------VI 280
Query: 167 VTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGE 226
VTGS+D T +VW V +G TL H AVL L T S D +I WD+ S
Sbjct: 281 VTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAVWDMASAT 338
Query: 227 QL---RVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKY 283
+ RV HR +V ++ ++ + S S DRT+K W T E VRT H+R ++ L+Y
Sbjct: 339 DITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY 398
Query: 284 HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVR 343
+ +GS D R +D + G RV GH ++ CI+ + + + ++DG +++WD++
Sbjct: 399 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQ 458
Query: 344 GLRGAPRPP 352
PR P
Sbjct: 459 AALD-PRAP 466
Score = 119 bits (299), Expect = 3e-27
Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 36/313 (11%)
Query: 23 LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82
L D +++++G D + ++W +C +L GH V Q ++ T S+D T+R W
Sbjct: 233 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVW 292
Query: 83 DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139
DV TG+ L H V + +N + + S DR+ VW + + R GHR
Sbjct: 293 DVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 352
Query: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
V + + + +V+ S D T KVW ++ +TL GH + C
Sbjct: 353 VNVVDFDDKY----------------IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIAC- 395
Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259
L +GS+D TIR WDI G LRV H V C+ N+ + SG+ D +K
Sbjct: 396 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 454
Query: 260 W---------LADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFD------AQS 304
W + C+RT H V L++ + + S D +D +
Sbjct: 455 WDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQ 514
Query: 305 GELRRVFRGHTFI 317
E R R +T+I
Sbjct: 515 NETRSPSRTYTYI 527
Score = 111 bits (278), Expect = 9e-25
Identities = 75/265 (28%), Positives = 114/265 (43%), Gaps = 32/265 (12%)
Query: 8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 67
L+V H G + L L D + ++TGS D T R+W G+ L H V + +
Sbjct: 260 LKVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 317
Query: 68 EAAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSV 124
TCS D +I WD+ + + + R GH + VN + + + S+S DRT +VWS
Sbjct: 318 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 377
Query: 125 DKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC 184
+ R GH+ + L Y L+V+GS+D T ++W + G
Sbjct: 378 STCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGA 421
Query: 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHR 235
C + L GH V C+ D +G+ D I+ WD+ + LR EH
Sbjct: 422 CLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS 479
Query: 236 GSVICLELVNRLVYSGSADRTVKCW 260
G V L+ + S S D T+ W
Sbjct: 480 GRVFRLQFDEFQIISSSHDDTILIW 504
Score = 64.3 bits (155), Expect = 2e-10
Identities = 30/117 (25%), Positives = 59/117 (50%)
Query: 226 EQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
++++ E+ V CL+ + + SG D ++K W + EC++ T H +V L+Y
Sbjct: 218 QRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE 277
Query: 286 GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342
+ TGS D+ R +D +GE+ H + ++ ++ T S D ++ +WD+
Sbjct: 278 RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDM 334
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 115 bits (289), Expect = 5e-26
Identities = 77/270 (28%), Positives = 122/270 (45%), Gaps = 16/270 (5%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
G R H + +S G+ L + S D T +LW +C + GH+ V+
Sbjct: 140 GDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVA 199
Query: 65 L--EDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ----LFSSSYDRT 118
+ + + S D TI+ W+V TG C++ + GH V +V NQ + S S D+T
Sbjct: 200 IMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVR--MVRPNQDGTLIASCSNDQT 257
Query: 119 ARVWSVDKGQMSREFRGHRNCVLTLA------YSAPWDLPSTPCAEEAAAGGLLVTGSTD 172
RVW V + E R H + V ++ YS+ + + + G L++GS D
Sbjct: 258 VRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317
Query: 173 GTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFR 232
T K+W V++G C TL GH V ++ + G + + D T+R WD + ++
Sbjct: 318 KTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLN 377
Query: 233 EHRGSVICLELVNRLVY--SGSADRTVKCW 260
H V L+ Y +GS D+TVK W
Sbjct: 378 AHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 114 bits (286), Expect = 1e-25
Identities = 82/318 (25%), Positives = 133/318 (41%), Gaps = 42/318 (13%)
Query: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF-- 71
HR + + P +++ SED T ++W G L+GH V +
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
Query: 72 TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN--QLFSSSYDRTARVWSVDKGQM 129
+CSAD TI+ WD +C++ GH V+ + + N + S+S D+T ++W V G
Sbjct: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226
Query: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTL 189
+ F GHR V + + G L+ + S D T +VW VA+ C L
Sbjct: 227 VKTFTGHREWVRMVRPNQD--------------GTLIASCSNDQTVRVWVVATKECKAEL 272
Query: 190 RGHTGAVLCL--------------------VLDTPGHTAFTGSTDATIRAWDILSGEQLR 229
R H V C+ PG +GS D TI+ WD+ +G L
Sbjct: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332
Query: 230 VFREHRGSV--ICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--A 285
H V + + + S + D+T++ W C++T AH V++L +H A
Sbjct: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTA 392
Query: 286 GTLFTGSGDACARAFDAQ 303
+ TGS D + ++ +
Sbjct: 393 PYVVTGSVDQTVKVWECR 410
Score = 107 bits (268), Expect = 1e-23
Identities = 86/321 (26%), Positives = 130/321 (40%), Gaps = 44/321 (13%)
Query: 53 LQGHESYVTFCQLEDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANN 108
L GH S VT + SA D TI+ WD TG + +GHT V I +
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 109 QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVT 168
L S S D T ++W + R GH + V ++A +P+ G +V+
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAI-----MPN---------GDHIVS 209
Query: 169 GSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL 228
S D T K+W+V +G C +T GH V + + G + S D T+R W + + E
Sbjct: 210 ASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECK 269
Query: 229 RVFREHRGSVICLELVNRLVYS----------------------GSADRTVKCWLADTGE 266
REH V C+ YS GS D+T+K W TG
Sbjct: 270 AELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGM 329
Query: 267 CVRTFTAHRRNVSALKYHAGTLF--TGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH 324
C+ T H V + +H+G F + + D R +D ++ + H + + H
Sbjct: 330 CLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFH 389
Query: 325 GQVLY--TASHDGALRLWDVR 343
Y T S D +++W+ R
Sbjct: 390 KTAPYVVTGSVDQTVKVWECR 410
>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
Length = 670
Score = 115 bits (289), Expect = 5e-26
Identities = 83/294 (28%), Positives = 139/294 (47%), Gaps = 27/294 (9%)
Query: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADG-QCCALLQGHESYVTFCQLEDEAAFT 72
H+G + L + G L +GS D T ++W T +C L+GH+ V ++ ++
Sbjct: 395 HQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYS 454
Query: 73 CSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSV--DKGQMS 130
SADCTI WD+ Q + R H + V ++ ++N LFS S + +VW + + ++
Sbjct: 455 GSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIKVWDIVGTELKLK 513
Query: 131 REFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLR 190
+E G + V L AA L +GS T K+W + + C L+
Sbjct: 514 KELTGLNHWVRAL----------------VAAQSYLYSGSYQ-TIKIWDIRTLDCIHVLQ 556
Query: 191 GHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVN----R 246
G+V + + H G+ + I WDI S EQ+R H G+V L +++
Sbjct: 557 TSGGSVYSIAV--TNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQT 614
Query: 247 LVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAF 300
V+S S DR+++ W D C +T H+ +V+AL G LF+G+ D+ + +
Sbjct: 615 KVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
Score = 76.6 bits (187), Expect = 3e-14
Identities = 76/302 (25%), Positives = 121/302 (40%), Gaps = 29/302 (9%)
Query: 48 QCCALLQGHESYV-TFCQLE-DEAAFTCSADCTIRRWDVLTG-QCLQVYRGHTSIVNRIL 104
+C GH+ V C + F+ S+D TI+ WD T +C + GH IV +
Sbjct: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
Query: 105 VANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGG 164
+ +L+S S D T VW + Q R H N V TL S
Sbjct: 447 IQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSH----------------N 490
Query: 165 LLVTGSTDGTAKVWQVASG--CCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
+L +GS KVW + + L G V LV ++GS TI+ WDI
Sbjct: 491 VLFSGSLKAI-KVWDIVGTELKLKKELTGLNHWVRALV--AAQSYLYSGSYQ-TIKIWDI 546
Query: 223 LSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALK 282
+ + + V + GSV + + N + G+ + + W ++ E VRT T H V AL
Sbjct: 547 RTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALA 606
Query: 283 Y----HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALR 338
+F+ S D R + + + H + + V L++ + D ++
Sbjct: 607 VISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVK 666
Query: 339 LW 340
+W
Sbjct: 667 VW 668
Score = 71.6 bits (174), Expect = 1e-12
Identities = 70/265 (26%), Positives = 114/265 (43%), Gaps = 31/265 (11%)
Query: 88 QCLQVYRGHTSIVNRILVAN--NQLFSSSYDRTARVWSV-DKGQMSREFRGHRNCVLTLA 144
+C + GH V + V + + LFS S D+T +VW + + GH VL L
Sbjct: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
Query: 145 YSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTP 204
G L +GS D T VW + + T+R H V LV +
Sbjct: 447 IQ----------------GCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLV--SS 488
Query: 205 GHTAFTGSTDATIRAWDILSGEQLRVFREHRGS---VICLELVNRLVYSGSADRTVKCWL 261
+ F+GS A I+ WDI+ G +L++ +E G V L +YSGS +T+K W
Sbjct: 489 HNVLFSGSLKA-IKVWDIV-GTELKLKKELTGLNHWVRALVAAQSYLYSGSY-QTIKIWD 545
Query: 262 ADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCI 321
T +C+ +V ++ + G+ + +D +S E R GH + +
Sbjct: 546 IRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYAL 605
Query: 322 QVHGQV----LYTASHDGALRLWDV 342
V +++AS+D +LR+W +
Sbjct: 606 AVISTPDQTKVFSASYDRSLRVWSM 630
Score = 41.6 bits (96), Expect = 0.001
Identities = 24/106 (22%), Positives = 44/106 (41%), Gaps = 4/106 (3%)
Query: 22 SLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL----EDEAAFTCSADC 77
S++ ++ G+ + +W + L GH V + + F+ S D
Sbjct: 564 SIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDR 623
Query: 78 TIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWS 123
++R W + C Q H V + V+ +LFS + D T +VW+
Sbjct: 624 SLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWT 669
Score = 40.0 bits (92), Expect = 0.003
Identities = 23/84 (27%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 266 ECVRTFTAHRRNVSALKYHA--GTLFTGSGDACARAFDA-QSGELRRVFRGHTFIINCIQ 322
+C TF H+ V L ++ LF+GS D + +D + + ++ GH I+ +
Sbjct: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
Query: 323 VHGQVLYTASHDGALRLWDVRGLR 346
+ G LY+ S D + +WD++ L+
Sbjct: 447 IQGCKLYSGSADCTIIVWDIQNLQ 470
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 114 bits (285), Expect = 1e-25
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 24/281 (8%)
Query: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
H ++ + SP+G+ L + S D +W DG+ L GH ++ +++
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 74 SA--DCTIRRWDVLTGQCLQVYRGHTSIV--NRILVANNQLFSSSYDRTARVWSVDKGQM 129
SA D T++ WDV +G+CL+ +GH++ V +N + S S+D T ++W V G+
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159
Query: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTL 189
+ H + V + ++ +G L+V+GS DG ++W ASG C +TL
Sbjct: 160 LKTLSAHSDPVSAVHFN--------------CSGSLIVSGSYDGLCRIWDAASGQCLKTL 205
Query: 190 RGHTGAVLCLVLDTP-GHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL-----EL 243
+ V +P G T + D T++ WD G L+ + H+ C+
Sbjct: 206 VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVT 265
Query: 244 VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH 284
+ + SGS D V W T E V+ H V + H
Sbjct: 266 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACH 306
Score = 108 bits (270), Expect = 8e-24
Identities = 71/261 (27%), Positives = 120/261 (45%), Gaps = 24/261 (9%)
Query: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
H I+ ++ S D RL++ S+D T +LW G+C L+GH +YV C +
Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLII 141
Query: 74 SA--DCTIRRWDVLTGQCLQVYRGHTSIVNRI--LVANNQLFSSSYDRTARVWSVDKGQM 129
S D T++ W+V TG+CL+ H+ V+ + + + + S SYD R+W GQ
Sbjct: 142 SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ- 200
Query: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTL 189
C+ TL D P + + G ++T + D T K+W + G C +T
Sbjct: 201 ---------CLKTLVDD---DNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY 248
Query: 190 RGHTGAVLCLVLD---TPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI---CLEL 243
GH C+ + T G +GS D + W++ + E ++ + H VI C
Sbjct: 249 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPT 308
Query: 244 VNRLVYSG-SADRTVKCWLAD 263
N + + D+T+K W+++
Sbjct: 309 ENLIASAALENDKTIKLWMSN 329
Score = 104 bits (259), Expect = 1e-22
Identities = 73/304 (24%), Positives = 134/304 (44%), Gaps = 30/304 (9%)
Query: 53 LQGHESYVTFCQLEDEAAF--TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN-- 108
L GH V+ + + + SAD I W G+ + GH ++ + +++
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 109 QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVT 168
+L S+S D+T ++W V G+ + +GH N V ++ P L+++
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPP--------------SNLIIS 142
Query: 169 GSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL 228
GS D T K+W+V +G C +TL H+ V + + G +GS D R WD SG+ L
Sbjct: 143 GSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCL 202
Query: 229 RVFREHRG---SVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
+ + S + + + + + D T+K W G C++T+T H+ + +
Sbjct: 203 KTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANF 262
Query: 286 GT-----LFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTAS----HDGA 336
+ +GS D ++ Q+ E+ + +GHT ++ H AS +D
Sbjct: 263 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKT 322
Query: 337 LRLW 340
++LW
Sbjct: 323 IKLW 326
Score = 100 bits (249), Expect = 2e-21
Identities = 69/261 (26%), Positives = 119/261 (45%), Gaps = 26/261 (9%)
Query: 95 GHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLP 152
GHT V+ + + N L SSS DR +W G+ + GH + +A+S+
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD---- 94
Query: 153 STPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS 212
LV+ S D T K+W V SG C +TL+GH+ V C + P + +GS
Sbjct: 95 ----------SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGS 144
Query: 213 TDATIRAWDILSGEQLRVFREHRG--SVICLELVNRLVYSGSADRTVKCWLADTGECVRT 270
D T++ W++ +G+ L+ H S + L+ SGS D + W A +G+C++T
Sbjct: 145 FDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKT 204
Query: 271 FT-AHRRNVSALKY--HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--- 324
VS +K+ + + T + D + +D G + + GH CI +
Sbjct: 205 LVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSV 264
Query: 325 --GQVLYTASHDGALRLWDVR 343
G+ + + S D + +W+++
Sbjct: 265 TGGKWIVSGSEDNLVYIWNLQ 285
Score = 70.5 bits (171), Expect = 2e-12
Identities = 43/182 (23%), Positives = 80/182 (43%), Gaps = 20/182 (10%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCC-ALLQGHESYVTFC 63
G L+ + H ++ + + G +++GS DG R+W A GQC L+ V+F
Sbjct: 157 GKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV 216
Query: 64 QLEDEAAF--TCSADCTIRRWDVLTGQCLQVYRGHTS-----IVNRILVANNQLFSSSYD 116
+ + T + D T++ WD G+CL+ Y GH + N + + S S D
Sbjct: 217 KFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 276
Query: 117 RTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAK 176
+W++ ++ ++ +GH + V++ A +L ++ E D T K
Sbjct: 277 NLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALE------------NDKTIK 324
Query: 177 VW 178
+W
Sbjct: 325 LW 326
Score = 70.1 bits (170), Expect = 3e-12
Identities = 51/227 (22%), Positives = 93/227 (40%), Gaps = 26/227 (11%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
G L+ H + + +P +++GS D T ++W G+C L H V+
Sbjct: 115 GKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVH 174
Query: 65 LEDEAAFTCSA--DCTIRRWDVLTGQCLQ-VYRGHTSIVNRILVANN--QLFSSSYDRTA 119
+ S D R WD +GQCL+ + V+ + + N + +++ D T
Sbjct: 175 FNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTL 234
Query: 120 RVWSVDKGQMSREFRGHRN---CVLTLAYSAPWDLPSTPCAEEAAAGG-LLVTGSTDGTA 175
++W +G+ + + GH+N C+ A + GG +V+GS D
Sbjct: 235 KLWDYSRGRCLKTYTGHKNEKYCIF---------------ANFSVTGGKWIVSGSEDNLV 279
Query: 176 KVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS--TDATIRAW 220
+W + + Q L+GHT V+ + + + D TI+ W
Sbjct: 280 YIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 110 bits (276), Expect = 2e-24
Identities = 72/283 (25%), Positives = 125/283 (44%), Gaps = 24/283 (8%)
Query: 12 ADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF 71
A H ++ + SP+G+ L + S D ++W DG+ + GH+ ++ ++
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 72 TCSA--DCTIRRWDVLTGQCLQVYRGHTSIV--NRILVANNQLFSSSYDRTARVWSVDKG 127
SA D T++ WDV +G+CL+ +GH++ V +N + S S+D + R+W V G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 128 QMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQ 187
+ + H + V + ++ G L+V+ S DG ++W ASG C +
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRD--------------GSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 188 TLRGHTGAVLCLVLDTP-GHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL----- 241
TL + V +P G + D T++ WD G+ L+ + H+ C+
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267
Query: 242 ELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH 284
+ + SGS D V W T E V+ H V + H
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310
Score = 110 bits (276), Expect = 2e-24
Identities = 73/270 (27%), Positives = 124/270 (45%), Gaps = 24/270 (8%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
G + + H+ GI+ ++ S D L++ S+D T ++W + G+C L+GH +YV C
Sbjct: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136
Query: 65 LEDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTAR 120
++ S D ++R WDV TG+CL+ H+ V+ + + + SSSYD R
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV 180
+W GQ C+ TL D P + + G ++ + D T K+W
Sbjct: 197 IWDTASGQ----------CLKTLIDD---DNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243
Query: 181 ASGCCHQTLRGHTGAVLCLVLD---TPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGS 237
+ G C +T GH C+ + T G +GS D + W++ + E ++ + H
Sbjct: 244 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303
Query: 238 VI---CLELVNRLVYSG-SADRTVKCWLAD 263
VI C N + + D+T+K W +D
Sbjct: 304 VISTACHPTENIIASAALENDKTIKLWKSD 333
Score = 101 bits (252), Expect = 1e-21
Identities = 72/304 (23%), Positives = 131/304 (43%), Gaps = 30/304 (9%)
Query: 53 LQGHESYVTFCQLEDEAAF--TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVAN--N 108
L GH V+ + + + SAD I+ W G+ + GH ++ + ++ N
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 109 QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVT 168
L S+S D+T ++W V G+ + +GH N V C L+V+
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVF--------------CCNFNPQSNLIVS 146
Query: 169 GSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL 228
GS D + ++W V +G C +TL H+ V + + G + S D R WD SG+ L
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206
Query: 229 RVFREHRG---SVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
+ + S + + + + + D T+K W G+C++T+T H+ + +
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 286 GT-----LFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTAS----HDGA 336
+ +GS D ++ Q+ E+ + +GHT ++ H AS +D
Sbjct: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKT 326
Query: 337 LRLW 340
++LW
Sbjct: 327 IKLW 330
Score = 99.0 bits (245), Expect = 6e-21
Identities = 68/262 (25%), Positives = 122/262 (46%), Gaps = 28/262 (10%)
Query: 95 GHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLP 152
GHT V+ + + N L SSS D+ ++W G+ + GH+ + +A+S+
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD---- 98
Query: 153 STPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS 212
LLV+ S D T K+W V+SG C +TL+GH+ V C + + +GS
Sbjct: 99 ----------SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148
Query: 213 TDATIRAWDILSGEQLRVFREHRGSVICLELVNR---LVYSGSADRTVKCWLADTGECVR 269
D ++R WD+ +G+ L+ H V + NR L+ S S D + W +G+C++
Sbjct: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHF-NRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 270 T-FTAHRRNVSALKY--HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH-- 324
T VS +K+ + + + D + +D G+ + + GH CI +
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267
Query: 325 ---GQVLYTASHDGALRLWDVR 343
G+ + + S D + +W+++
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQ 289
Score = 72.0 bits (175), Expect = 8e-13
Identities = 40/160 (25%), Positives = 77/160 (48%), Gaps = 6/160 (3%)
Query: 188 TLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV--ICLELVN 245
TL GHT AV + G + S D I+ W G+ + H+ + + +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 246 RLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFDAQ 303
L+ S S D+T+K W +G+C++T H V ++ + + +GS D R +D +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 304 SGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWD 341
+G+ + H+ ++ + + G ++ ++S+DG R+WD
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 110 bits (276), Expect = 2e-24
Identities = 72/283 (25%), Positives = 125/283 (44%), Gaps = 24/283 (8%)
Query: 12 ADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF 71
A H ++ + SP+G+ L + S D ++W DG+ + GH+ ++ ++
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 72 TCSA--DCTIRRWDVLTGQCLQVYRGHTSIV--NRILVANNQLFSSSYDRTARVWSVDKG 127
SA D T++ WDV +G+CL+ +GH++ V +N + S S+D + R+W V G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 128 QMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQ 187
+ + H + V + ++ G L+V+ S DG ++W ASG C +
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRD--------------GSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 188 TLRGHTGAVLCLVLDTP-GHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL----- 241
TL + V +P G + D T++ WD G+ L+ + H+ C+
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267
Query: 242 ELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH 284
+ + SGS D V W T E V+ H V + H
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310
Score = 110 bits (276), Expect = 2e-24
Identities = 73/270 (27%), Positives = 124/270 (45%), Gaps = 24/270 (8%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
G + + H+ GI+ ++ S D L++ S+D T ++W + G+C L+GH +YV C
Sbjct: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136
Query: 65 LEDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTAR 120
++ S D ++R WDV TG+CL+ H+ V+ + + + SSSYD R
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV 180
+W GQ C+ TL D P + + G ++ + D T K+W
Sbjct: 197 IWDTASGQ----------CLKTLIDD---DNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243
Query: 181 ASGCCHQTLRGHTGAVLCLVLD---TPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGS 237
+ G C +T GH C+ + T G +GS D + W++ + E ++ + H
Sbjct: 244 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303
Query: 238 VI---CLELVNRLVYSG-SADRTVKCWLAD 263
VI C N + + D+T+K W +D
Sbjct: 304 VISTACHPTENIIASAALENDKTIKLWKSD 333
Score = 101 bits (252), Expect = 1e-21
Identities = 72/304 (23%), Positives = 131/304 (43%), Gaps = 30/304 (9%)
Query: 53 LQGHESYVTFCQLEDEAAF--TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVAN--N 108
L GH V+ + + + SAD I+ W G+ + GH ++ + ++ N
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 109 QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVT 168
L S+S D+T ++W V G+ + +GH N V C L+V+
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVF--------------CCNFNPQSNLIVS 146
Query: 169 GSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL 228
GS D + ++W V +G C +TL H+ V + + G + S D R WD SG+ L
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206
Query: 229 RVFREHRG---SVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
+ + S + + + + + D T+K W G+C++T+T H+ + +
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 286 GT-----LFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTAS----HDGA 336
+ +GS D ++ Q+ E+ + +GHT ++ H AS +D
Sbjct: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKT 326
Query: 337 LRLW 340
++LW
Sbjct: 327 IKLW 330
Score = 99.0 bits (245), Expect = 6e-21
Identities = 68/262 (25%), Positives = 122/262 (46%), Gaps = 28/262 (10%)
Query: 95 GHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLP 152
GHT V+ + + N L SSS D+ ++W G+ + GH+ + +A+S+
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD---- 98
Query: 153 STPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS 212
LLV+ S D T K+W V+SG C +TL+GH+ V C + + +GS
Sbjct: 99 ----------SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148
Query: 213 TDATIRAWDILSGEQLRVFREHRGSVICLELVNR---LVYSGSADRTVKCWLADTGECVR 269
D ++R WD+ +G+ L+ H V + NR L+ S S D + W +G+C++
Sbjct: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHF-NRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 270 T-FTAHRRNVSALKY--HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH-- 324
T VS +K+ + + + D + +D G+ + + GH CI +
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267
Query: 325 ---GQVLYTASHDGALRLWDVR 343
G+ + + S D + +W+++
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQ 289
Score = 72.0 bits (175), Expect = 8e-13
Identities = 40/160 (25%), Positives = 77/160 (48%), Gaps = 6/160 (3%)
Query: 188 TLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV--ICLELVN 245
TL GHT AV + G + S D I+ W G+ + H+ + + +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 246 RLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFDAQ 303
L+ S S D+T+K W +G+C++T H V ++ + + +GS D R +D +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 304 SGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWD 341
+G+ + H+ ++ + + G ++ ++S+DG R+WD
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 110 bits (276), Expect = 2e-24
Identities = 73/222 (32%), Positives = 98/222 (44%), Gaps = 18/222 (8%)
Query: 6 SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL 65
S L++ H G + S SPD LL+ SEDGT RLWS C +GH V Q
Sbjct: 534 SELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQF 593
Query: 66 EDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARV 121
+ S D R W Q L+++ GH + VN R +N + + S DRT R+
Sbjct: 594 SPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRL 653
Query: 122 WSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181
W V G R F GH+ + +L +S G L TG+TDG +W +
Sbjct: 654 WDVLNGNCVRIFTGHKGPIHSLTFSPN--------------GRFLATGATDGRVLLWDIG 699
Query: 182 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDIL 223
G L+GHT V L G +GS D T+R WD +
Sbjct: 700 HGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741
Score = 92.8 bits (229), Expect = 4e-19
Identities = 65/233 (27%), Positives = 92/233 (39%), Gaps = 20/233 (8%)
Query: 34 SEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSA--DCTIRRWDVLTGQCLQ 91
S+D R+ +L GH V + + S+ D T+R W + T CL
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 579
Query: 92 VYRGHTSIV--NRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPW 149
Y+GH V + S +DR AR+W+ D Q R F GH
Sbjct: 580 GYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGH------------- 626
Query: 150 DLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAF 209
L C + TGS D T ++W V +G C + GH G + L G
Sbjct: 627 -LADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLA 685
Query: 210 TGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCW 260
TG+TD + WDI G + + H +V L ++ SGS D TV+ W
Sbjct: 686 TGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 87.0 bits (214), Expect = 2e-17
Identities = 55/182 (30%), Positives = 84/182 (46%), Gaps = 6/182 (3%)
Query: 166 LVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSG 225
L++ S DGT ++W + + C +GH V G+ +G D R W
Sbjct: 558 LLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHY 617
Query: 226 EQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKY 283
+ LR+F H V C + V +GSADRTV+ W G CVR FT H+ + +L +
Sbjct: 618 QPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTF 677
Query: 284 HAGTLF--TGSGDACARAFDAQSGELRRVFRGHTFIINCIQV--HGQVLYTASHDGALRL 339
F TG+ D +D G + +GHT + ++ G++L + S D +RL
Sbjct: 678 SPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRL 737
Query: 340 WD 341
WD
Sbjct: 738 WD 739
Score = 70.5 bits (171), Expect = 2e-12
Identities = 64/260 (24%), Positives = 107/260 (41%), Gaps = 35/260 (13%)
Query: 90 LQVYRGHTSIVNRILVANNQLFSSSY-DRTARVWSVDKGQMSREFRGHRNCVLTLAYSAP 148
L Y+G T++ + ++ L + + D T RVWSV P
Sbjct: 467 LNAYQGLTAVD---VTDDSSLIAGGFADSTVRVWSV----------------------TP 501
Query: 149 WDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTA 208
L S A + + L+ S D ++ + + L GH+G V +
Sbjct: 502 KKLRSVKQASDLS---LIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYL 558
Query: 209 FTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVY--SGSADRTVKCWLADTGE 266
+ S D T+R W + + L ++ H V + Y SG DR + W D +
Sbjct: 559 LSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQ 618
Query: 267 CVRTFTAHRRNVSALKYHAGTLF--TGSGDACARAFDAQSGELRRVFRGHTFIINCIQV- 323
+R F H +V+ ++H + + TGS D R +D +G R+F GH I+ +
Sbjct: 619 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 678
Query: 324 -HGQVLYTASHDGALRLWDV 342
+G+ L T + DG + LWD+
Sbjct: 679 PNGRFLATGATDGRVLLWDI 698
Score = 53.9 bits (128), Expect = 2e-07
Identities = 30/85 (35%), Positives = 44/85 (51%), Gaps = 6/85 (7%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
G+ +R+ H+G I+ L+ SP+G+ L TG+ DG LW G L+GH T C
Sbjct: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD--TVCS 716
Query: 65 L----EDEAAFTCSADCTIRRWDVL 85
L + E + S D T+R WD +
Sbjct: 717 LRFSRDGEILASGSMDNTVRLWDAI 741
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 108 bits (269), Expect = 1e-23
Identities = 93/331 (28%), Positives = 141/331 (42%), Gaps = 44/331 (13%)
Query: 11 CADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADG-QCCALLQGHESYVTFCQLE--- 66
C HR + +S SPDG++L +G ++G LW + G Q L GH ++T E
Sbjct: 152 CKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLH 211
Query: 67 --DEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVNRI-LVANNQLFSSSYDRTARV 121
E + S+ D ++R WD G+C ++ GHT V + + L+S+S DRT +V
Sbjct: 212 ANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKV 271
Query: 122 WSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAA--------GGL-------- 165
W G + R +GH + V T+A S + L T E A A G L
Sbjct: 272 WRAHDGVLCRTLQGHGHWVNTMALSTDYAL-RTGAFEPAEASVNPQDLQGSLQELKERAL 330
Query: 166 -------------LVTGSTDGTAKVWQVASGCCHQT-LRGHTGAVLCLVLDTPGHTAFTG 211
LV+GS D T +W A T + GH + ++ +
Sbjct: 331 SRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASA 390
Query: 212 STDATIRAWDILSGEQLRVFREHRGSV--ICLELVNRLVYSGSADRTVKCWLADTGECVR 269
S D +I+ WD +G+ L R H +V I +RL+ SGS+D T+K W +
Sbjct: 391 SFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAM 450
Query: 270 TFTAHRRNVSALKY--HAGTLFTGSGDACAR 298
H V A+ + + +G D C R
Sbjct: 451 DLPGHADEVYAVDWSPDGQRVASGGKDKCLR 481
Score = 86.3 bits (212), Expect = 4e-17
Identities = 89/349 (25%), Positives = 149/349 (42%), Gaps = 36/349 (10%)
Query: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
H + ++ SP G+ L +GS D T R W + +GH +V +
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172
Query: 74 SA--DCTIRRWDVLTG-QCLQVYRGHTSIVNRI----LVANNQ---LFSSSYDRTARVWS 123
S + I WD TG Q + GH+ + + L AN + + SSS D + R+W
Sbjct: 173 SGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232
Query: 124 VDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASG 183
G+ R GH V L + GLL + S D T KVW+ G
Sbjct: 233 TTAGRCERILTGHTQSVTCLRW---------------GGDGLLYSASQDRTIKVWRAHDG 277
Query: 184 CCHQTLRGHTGAVLCLVLDTPGHTAFTGS---TDATIRAWDIL-SGEQLRVFREHRGSVI 239
+TL+GH V + L T + TG+ +A++ D+ S ++L+ R +++
Sbjct: 278 VLCRTLQGHGHWVNTMALST-DYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLV 336
Query: 240 CLELVNRLVYSGSADRTVKCWL-ADTGECVRTFTAHRRNVSALKYHAGTLFTGSG--DAC 296
+ RLV SGS D T+ W A+ + + T H+ ++ + + + S D
Sbjct: 337 RGQGPERLV-SGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKS 395
Query: 297 ARAFDAQSGELRRVFRGHTFIINCI--QVHGQVLYTASHDGALRLWDVR 343
+ +D ++G+ RGH + I ++L + S D L++WDV+
Sbjct: 396 IKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 444
Score = 73.6 bits (179), Expect = 3e-13
Identities = 67/251 (26%), Positives = 102/251 (40%), Gaps = 33/251 (13%)
Query: 120 RVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQ 179
RV +V + S E GH V+++A+S G L +GS D T + W
Sbjct: 99 RVRAVTRCTSSLE--GHSEAVISVAFSP--------------TGKYLASGSGDTTVRFWD 142
Query: 180 VASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL-RVFREHRGSV 238
+++ H T +GH VL + G +G + I WD +G+Q+ R H +
Sbjct: 143 LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWI 202
Query: 239 ICLELVN-------RLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA-GTLFT 290
L R V S S D +V+ W G C R T H ++V+ L++ G L++
Sbjct: 203 TGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYS 262
Query: 291 GSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPR 350
S D + + A G L R +GH +N + + S D ALR +
Sbjct: 263 ASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMAL--------STDYALRTGAFEPAEASVN 314
Query: 351 PPPPMRSLSRL 361
P SL L
Sbjct: 315 PQDLQGSLQEL 325
Score = 72.8 bits (177), Expect = 5e-13
Identities = 65/295 (22%), Positives = 117/295 (39%), Gaps = 66/295 (22%)
Query: 17 GINW--LSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLE-DEAAFTC 73
G++W L +P+ + + + S+DG+ R+W T G+C +L GH VT + D ++
Sbjct: 204 GLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSA 263
Query: 74 SADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN------------------------- 108
S D TI+ W G + +GH VN + ++ +
Sbjct: 264 SQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQ 323
Query: 109 -------------------QLFSSSYDRTARVWSV--DKGQMSREFRGHRNCVLTLAYSA 147
+L S S D T +WS DK ++R GH+ + + +S
Sbjct: 324 ELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTR-MTGHQALINQVLFSP 382
Query: 148 PWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHT 207
++ + S D + K+W +G +LRGH AV +
Sbjct: 383 D--------------SRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRL 428
Query: 208 AFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCW 260
+GS+D+T++ WD+ + + H V ++ + V SG D+ ++ W
Sbjct: 429 LVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 30.4 bits (67), Expect = 2.7
Identities = 20/83 (24%), Positives = 33/83 (39%), Gaps = 2/83 (2%)
Query: 2 GGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGH--ESY 59
G G L H + ++ S D + L++GS D T ++W + L GH E Y
Sbjct: 401 GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVY 460
Query: 60 VTFCQLEDEAAFTCSADCTIRRW 82
+ + + D +R W
Sbjct: 461 AVDWSPDGQRVASGGKDKCLRIW 483
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 103 bits (256), Expect = 3e-22
Identities = 74/261 (28%), Positives = 120/261 (45%), Gaps = 22/261 (8%)
Query: 52 LLQGHESYVTFCQLE--DEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ 109
++ GH +V +E ++ T SAD TI+ WD+ +G+ GH S V ++V+
Sbjct: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRS 258
Query: 110 --LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLV 167
LFS D+ + W ++ ++ R + GH + V L D+ LV
Sbjct: 259 PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDV--------------LV 304
Query: 168 TGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ 227
T S D TA++W V + TL GHT AV + TGS D TIR WD+++G+
Sbjct: 305 TCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKT 364
Query: 228 LRVFREHRGSVICLELVNR--LVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
H+ SV + L R SGS D +K W G ++ + H ++ L ++
Sbjct: 365 RVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNS 423
Query: 286 -GTLFTGSGDACARAFDAQSG 305
G L +G+ + +D ++G
Sbjct: 424 DGVLVSGADNGTMHLWDWRTG 444
Score = 98.6 bits (244), Expect = 8e-21
Identities = 71/262 (27%), Positives = 113/262 (43%), Gaps = 20/262 (7%)
Query: 9 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV--TFCQLE 66
RV + H G + +++ P Q +TGS D T ++W A G+ L GH S V
Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
Query: 67 DEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTARVWSV 124
F+C D ++ WD+ + ++ Y GH S V + + + L + S D TAR+W V
Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
Query: 125 DKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC 184
GH N V T+ AA ++TGS D T ++W + +G
Sbjct: 318 RTKASVHTLSGHTNAVATVRCQ--------------AAEPQIITGSHDTTIRLWDLVAGK 363
Query: 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEL- 243
TL H +V +VL P H F + I+ W G ++ H + L +
Sbjct: 364 TRVTLTNHKKSVRAVVLH-PRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVN 422
Query: 244 VNRLVYSGSADRTVKCWLADTG 265
+ ++ SG+ + T+ W TG
Sbjct: 423 SDGVLVSGADNGTMHLWDWRTG 444
Score = 77.4 bits (189), Expect = 2e-14
Identities = 48/164 (29%), Positives = 77/164 (46%), Gaps = 8/164 (4%)
Query: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV--ICLEL 243
++ + GH G V C+ ++ TGS D TI+ WD+ SG+ H +V + +
Sbjct: 197 YRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVST 256
Query: 244 VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH--AGTLFTGSGDACARAFD 301
+ ++S D+ VKCW + + +R + H V L H L T S D+ AR +D
Sbjct: 257 RSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316
Query: 302 AQSGELRRVFRGHT---FIINCIQVHGQVLYTASHDGALRLWDV 342
++ GHT + C Q++ T SHD +RLWD+
Sbjct: 317 VRTKASVHTLSGHTNAVATVRCQAAEPQII-TGSHDTTIRLWDL 359
Score = 56.6 bits (135), Expect = 4e-08
Identities = 38/121 (31%), Positives = 58/121 (47%), Gaps = 6/121 (4%)
Query: 229 RVFREHRGSVICL--ELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSAL--KYH 284
RV H G V C+ E N+ +GSADRT+K W +G+ + T H V +
Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
Query: 285 AGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHG--QVLYTASHDGALRLWDV 342
+ LF+ D + +D + ++ R + GH + + +H VL T S D R+WDV
Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
Query: 343 R 343
R
Sbjct: 318 R 318
Score = 46.6 bits (109), Expect = 4e-05
Identities = 43/180 (23%), Positives = 71/180 (39%), Gaps = 16/180 (8%)
Query: 6 SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL 65
+++ + H + + +++TGS D T RLW G+ L H+ V L
Sbjct: 321 ASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVL 380
Query: 66 ED-EAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDR-TARVWS 123
F + I++W G +Q GH +I+N + V ++ + S D T +W
Sbjct: 381 HPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLW- 439
Query: 124 VDKGQMSREFRGHRNCVLTLAYSAPWDLPST----PCAEEAAAGGLLVTGSTDGTAKVWQ 179
++R N A P L S CA + + LL T D T KV++
Sbjct: 440 --------DWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLL-TAEADKTIKVYR 490
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 97.4 bits (241), Expect = 2e-20
Identities = 80/325 (24%), Positives = 125/325 (38%), Gaps = 63/325 (19%)
Query: 18 INWLSLSPDGQRLLTGSEDGTARLWSTAD------------------------------- 46
+N +SPD + L G ++ +LWS
Sbjct: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDN 330
Query: 47 -GQCCALLQGH--ESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRI 103
G +L+GH Y T + +CS D +IR WD+ + +Y+GH V +
Sbjct: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL 390
Query: 104 LVANNQLF--SSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAA 161
++ L+ S S+DRTAR+WS D+ R + GH L C +
Sbjct: 391 DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGH--------------LADVDCVKFHP 436
Query: 162 AGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 221
L TGSTD T ++W G + GH G VL L G + D ++ WD
Sbjct: 437 NSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD 496
Query: 222 ILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCW-----------LADTGECV 268
+ SG + R H ++ L + L+ S S D +V+ W + E V
Sbjct: 497 LASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELV 556
Query: 269 RTFTAHRRNVSALKYHAGTLFTGSG 293
+T NV ++++ A L +G
Sbjct: 557 GVYTGQMSNVLSVQFMACNLLLVTG 581
Score = 95.1 bits (235), Expect = 9e-20
Identities = 65/222 (29%), Positives = 96/222 (43%), Gaps = 18/222 (8%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
G+ +++ H G + D LL+ SED + R W L QGH V
Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLD 391
Query: 65 LEDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTAR 120
+ + + S D T R W L++Y GH + V+ + +N L + S D+T R
Sbjct: 392 ISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVR 451
Query: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV 180
+WS +G R F GHR VL+LA+S G L + D K+W +
Sbjct: 452 LWSAQQGNSVRLFTGHRGPVLSLAFS--------------PNGKYLASAGEDQRLKLWDL 497
Query: 181 ASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
ASG ++ LRGHT + L + S D ++R WDI
Sbjct: 498 ASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 77.8 bits (190), Expect = 1e-14
Identities = 55/184 (29%), Positives = 84/184 (45%), Gaps = 6/184 (3%)
Query: 166 LVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSG 225
L++ S D + + W + S +GH V L + +GS D T R W
Sbjct: 357 LLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRT 416
Query: 226 EQLRVFREHRGSVICLELVNRLVY--SGSADRTVKCWLADTGECVRTFTAHRRNVSALKY 283
LR++ H V C++ Y +GS D+TV+ W A G VR FT HR V +L +
Sbjct: 417 YPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAF 476
Query: 284 HAGTLFTGSG--DACARAFDAQSGELRRVFRGHTFIINCIQVHGQ--VLYTASHDGALRL 339
+ S D + +D SG L + RGHT I + ++ +AS D ++R+
Sbjct: 477 SPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRV 536
Query: 340 WDVR 343
WD+R
Sbjct: 537 WDIR 540
Score = 73.9 bits (180), Expect = 2e-13
Identities = 51/160 (31%), Positives = 75/160 (46%), Gaps = 6/160 (3%)
Query: 189 LRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLV 248
LRGH G V + S D +IR WD+ S +++ H V L++ +
Sbjct: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSL 397
Query: 249 Y--SGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGT--LFTGSGDACARAFDAQS 304
Y SGS DRT + W D +R + H +V +K+H + L TGS D R + AQ
Sbjct: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457
Query: 305 GELRRVFRGH--TFIINCIQVHGQVLYTASHDGALRLWDV 342
G R+F GH + +G+ L +A D L+LWD+
Sbjct: 458 GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDL 497
Score = 53.5 bits (127), Expect = 3e-07
Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 2/96 (2%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
G+++R+ HRG + L+ SP+G+ L + ED +LW A G L+GH +T
Sbjct: 458 GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLT 517
Query: 65 LEDEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTS 98
++ SA D ++R WD+ C G +S
Sbjct: 518 FSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSS 553
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 95.5 bits (236), Expect = 7e-20
Identities = 70/255 (27%), Positives = 112/255 (43%), Gaps = 14/255 (5%)
Query: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQ---CCALLQGHESYVTFCQL--EDE 68
+R G+N L L P RL T D R+WS + A ++ H +V L +
Sbjct: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88
Query: 69 AAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWSVDK 126
+ S+D T++ W+ G C+ R H V + A ++ + S+ DR +W V+
Sbjct: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148
Query: 127 GQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCH 186
N V T + S D + + G ++V+GST+ +VW +
Sbjct: 149 ---LTALTASNNTVTTSSLSGNKDSIYSLAMNQL--GTIIVSGSTEKVLRVWDPRTCAKL 203
Query: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR 246
L+GHT V L+L+ G +GS+D TIR W + + +R H V L++ +
Sbjct: 204 MKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDA 263
Query: 247 L--VYSGSADRTVKC 259
VYSG DR + C
Sbjct: 264 FTHVYSGGRDRKIYC 278
Score = 72.4 bits (176), Expect = 6e-13
Identities = 83/348 (23%), Positives = 132/348 (37%), Gaps = 51/348 (14%)
Query: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
H +N + L +G+ L++ S D T ++W+ G C + L+ H+ YV +
Sbjct: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVA 133
Query: 74 SA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILVAN---------NQL----FSSSYDRT 118
SA D I WDV T L + ++ L N NQL S S ++
Sbjct: 134 SAGLDRQIFLWDVNTLTALTA--SNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKV 191
Query: 119 ARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVW 178
RVW + +GH + V L + T C ++GS+DGT ++W
Sbjct: 192 LRVWDPRTCAKLMKLKGHTDNVKALLLNRD----GTQC----------LSGSSDGTIRLW 237
Query: 179 QVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV 238
+ C T R H V L ++ ++G D I D+ + + + E + V
Sbjct: 238 SLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPV 297
Query: 239 ICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGD---A 295
+ +EL SAD W+A T V +T + F SGD
Sbjct: 298 LKMEL------DRSADPPPAIWVATTKSTVNKWTLKGIH----------NFRASGDYDND 341
Query: 296 CARAFDAQSGELRRVFRGHTFIINC-IQVHGQVLYTASHDGALRLWDV 342
C + +V +G II C I + + T + + WDV
Sbjct: 342 CTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDV 389
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 95.1 bits (235), Expect = 9e-20
Identities = 64/217 (29%), Positives = 100/217 (46%), Gaps = 12/217 (5%)
Query: 161 AAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 220
A+G LL TG D +W + C +L GHT V + L+TP GS +IR W
Sbjct: 31 ASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVW 90
Query: 221 DILSGEQLRVFREHRGSVICLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNV 278
D+ + + LR H+ ++ L+ V SGS D +K W CV + H + V
Sbjct: 91 DLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAV 150
Query: 279 SALKY--HAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQ--VLYTASHD 334
L++ L + + D + +D +G++ F GHT +N ++ H +L + S D
Sbjct: 151 RCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSD 210
Query: 335 GALRLWDVRGLRGA---PRPPPPMRSLSRLFSNKVGC 368
+R WD+ + P P+RS+ LF N GC
Sbjct: 211 RTIRFWDLEKFQVVSCIEGEPGPVRSV--LF-NPDGC 244
Score = 75.9 bits (185), Expect = 6e-14
Identities = 59/214 (27%), Positives = 87/214 (40%), Gaps = 19/214 (8%)
Query: 14 HRGGINWLSLSPDGQRLL-TGSEDGTARLWSTADGQCCALLQGHESYVTFCQLE--DEAA 70
H ++ L L RLL TG +D LWS C L GH S V +L +E
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 71 FTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLF--SSSYDRTARVWSVDKGQ 128
S +IR WD+ + L+ GH + + + F S S D ++W + +
Sbjct: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138
Query: 129 MSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQT 188
+RGH V L +S G L + + D T K+W + +G
Sbjct: 139 CVFRYRGHSQAVRCLRFSPD--------------GKWLASAADDHTVKLWDLTAGKMMSE 184
Query: 189 LRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
GHTG V + + +GS+D TIR WD+
Sbjct: 185 FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218
Score = 74.7 bits (182), Expect = 1e-13
Identities = 62/267 (23%), Positives = 108/267 (40%), Gaps = 20/267 (7%)
Query: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
H + + L+ + ++ GS+ G+ R+W + L GH++ + F
Sbjct: 62 HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVA 121
Query: 74 SA--DCTIRRWDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARVWSVDKGQM 129
S D I+ WD+ C+ YRGH+ V R L S++ D T ++W + G+M
Sbjct: 122 SGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKM 181
Query: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTL 189
EF GH V + + P+ LL +GS+D T + W + +
Sbjct: 182 MSEFPGHTGPVNVVEFH-----PNEY---------LLASGSSDRTIRFWDLEKFQVVSCI 227
Query: 190 RGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVN-RLV 248
G G V ++ + G ++G D ++R + V + G V L + N +L+
Sbjct: 228 EGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERCFDVVLVNWGKVADLAICNDQLI 286
Query: 249 YSGSADRTVKCWLADTGECVRTFTAHR 275
+ V ++ D RT T R
Sbjct: 287 GVAFSQSNVSSYVVDLTRVTRTGTVAR 313
Score = 66.6 bits (161), Expect = 3e-11
Identities = 41/143 (28%), Positives = 66/143 (46%), Gaps = 4/143 (2%)
Query: 8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 67
LR H+ I L P G+ + +GS+D +LW C +GH V +
Sbjct: 98 LRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSP 157
Query: 68 EAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWS 123
+ + SA D T++ WD+ G+ + + GHT VN + N+ L S S DRT R W
Sbjct: 158 DGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
Query: 124 VDKGQMSREFRGHRNCVLTLAYS 146
++K Q+ G V ++ ++
Sbjct: 218 LEKFQVVSCIEGEPGPVRSVLFN 240
Score = 49.3 bits (116), Expect = 6e-06
Identities = 30/132 (22%), Positives = 60/132 (45%), Gaps = 7/132 (5%)
Query: 216 TIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHR 275
T AW + +++ + S++ + RL+ +G D V W + C+ + T H
Sbjct: 7 TKTAWKL---QEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHT 63
Query: 276 RNVSALKYHA--GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTA 331
V +++ + + GS R +D ++ ++ R GH I + H G+ + +
Sbjct: 64 SPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASG 123
Query: 332 SHDGALRLWDVR 343
S D ++LWD+R
Sbjct: 124 SQDTNIKLWDIR 135
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 94.7 bits (234), Expect = 1e-19
Identities = 77/304 (25%), Positives = 124/304 (40%), Gaps = 35/304 (11%)
Query: 9 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 68
R H I + + D + L++ S+DG +W + + S+V C
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 69 AAFTCSAD----CTI-----RRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTA 119
F C+I R +V + L + G+ S + +N + +SS D T
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCR--FLDDNNIVTSSGDTTC 166
Query: 120 RVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQ 179
+W ++ GQ F GH ++LA S ++L ++G+ D +AK+W
Sbjct: 167 ALWDIETGQQKTVFVGHTGDCMSLAVSPDFNL--------------FISGACDASAKLWD 212
Query: 180 VASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
V G C QT GH + + G TGS DA+ R +D+ + ++L F S+I
Sbjct: 213 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHE--SII 270
Query: 240 C------LELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAG--TLFTG 291
C L RL+++G D W + E V + H VS L A + TG
Sbjct: 271 CGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATG 330
Query: 292 SGDA 295
S D+
Sbjct: 331 SWDS 334
Score = 68.2 bits (165), Expect = 1e-11
Identities = 73/312 (23%), Positives = 114/312 (36%), Gaps = 77/312 (24%)
Query: 85 LTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLA 144
L G ++Y H + +++LV S+S D VW + V+T A
Sbjct: 51 LRGHLAKIYAMHWATDSKLLV------SASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCA 104
Query: 145 YSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASG----CCHQTLRGHTGAVLCL- 199
Y A +G + G D ++ + S + L HTG + C
Sbjct: 105 Y--------------APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCR 150
Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVN--RLVYSGSADRTV 257
LD + T S D T WDI +G+Q VF H G + L + L SG+ D +
Sbjct: 151 FLDD--NNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASA 208
Query: 258 KCWLADTGECVRTFTAHRRNVSALKY--HAGTLFTGSGDACARAFDAQS----------- 304
K W G C +TFT H +++A+ + + + TGS DA R FD ++
Sbjct: 209 KLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHES 268
Query: 305 ---------------------------------GELRRVFRGHTFIINCIQV--HGQVLY 329
E + GH ++C+ V G +
Sbjct: 269 IICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVA 328
Query: 330 TASHDGALRLWD 341
T S D L++W+
Sbjct: 329 TGSWDSFLKIWN 340
Score = 66.2 bits (160), Expect = 4e-11
Identities = 50/202 (24%), Positives = 77/202 (38%), Gaps = 33/202 (16%)
Query: 53 LQGHESYVTFCQ-LEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVAN--NQ 109
L H Y++ C+ L+D T S D T WD+ TGQ V+ GHT + V+ N
Sbjct: 139 LSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNL 198
Query: 110 LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAA-------- 161
S + D +A++W V +G + F GH + + + + + T + +
Sbjct: 199 FISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRAD 258
Query: 162 ----------------------AGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
+G LL G D VW L GH V CL
Sbjct: 259 QELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCL 318
Query: 200 VLDTPGHTAFTGSTDATIRAWD 221
+ G TGS D+ ++ W+
Sbjct: 319 GVTADGMAVATGSWDSFLKIWN 340
Score = 60.5 bits (145), Expect = 2e-09
Identities = 52/181 (28%), Positives = 73/181 (40%), Gaps = 22/181 (12%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV-TFC 63
G V H G L++SPD ++G+ D +A+LW +G C GHES + C
Sbjct: 174 GQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAIC 233
Query: 64 QLED-EAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRIL-----VANNQLFSSSYDR 117
+ EA T S D + R +D+ Q L + H SI+ I ++ LF+ D
Sbjct: 234 FFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICGITSVAFSLSGRLLFAGYDDF 292
Query: 118 TARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKV 177
VW K + GH N V C A G + TGS D K+
Sbjct: 293 NCNVWDSMKSERVGILSGHDNRV--------------SCLGVTADGMAVATGSWDSFLKI 338
Query: 178 W 178
W
Sbjct: 339 W 339
Score = 43.5 bits (101), Expect = 3e-04
Identities = 37/166 (22%), Positives = 64/166 (38%), Gaps = 9/166 (5%)
Query: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV-- 244
+TLRGH + + T + S D + WD + ++ V+
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 245 NRLVYSGSADRTVKCWLADTGE----CVRTFTAHRRNVSALKY-HAGTLFTGSGDACARA 299
V G D + + E R +AH +S ++ + T SGD
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCAL 168
Query: 300 FDAQSGELRRVFRGHTFIINCIQVHG--QVLYTASHDGALRLWDVR 343
+D ++G+ + VF GHT + V + + + D + +LWDVR
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 93.2 bits (230), Expect = 3e-19
Identities = 72/288 (25%), Positives = 130/288 (45%), Gaps = 44/288 (15%)
Query: 24 SPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC---------- 73
SPDGQ L+TGS DG +W+ G+ L+ +++ F ++D C
Sbjct: 223 SPDGQYLVTGSVDGFIEVWNFTTGKIRKDLK-YQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 74 -SADCTIRRWDVLTGQCLQVY-RGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQM 129
+ D I+ W + +GQCL+ + R H+ V + + ++Q+ S+S+D+T R+ + G+
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTL 189
+EFRGH + V ++ G +++ S+DGT K+W + + C T
Sbjct: 342 LKEFRGHSSFVNEATFTQD--------------GHYIISASSDGTVKIWNMKTTECSNTF 387
Query: 190 R--GHTGAV------LCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVF---REHRGSV 238
+ G T + L+ P H ++ + + G+ +R F + G
Sbjct: 388 KSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIM--NMQGQIVRSFSSGKREGGDF 445
Query: 239 ICLELVNR--LVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH 284
+C L R +Y D + C+ TG+ RT T H ++V + +H
Sbjct: 446 VCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHH 493
Score = 65.1 bits (157), Expect = 1e-10
Identities = 40/168 (23%), Positives = 74/168 (44%), Gaps = 15/168 (8%)
Query: 191 GHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLR----------VFREHRGSVIC 240
G V C G TGS D I W+ +G+ + + + +C
Sbjct: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
Query: 241 LELVNRLVYSGSADRTVKCWLADTGECVRTFT-AHRRNVSALKYH--AGTLFTGSGDACA 297
++ +G+ D +K W +G+C+R F AH + V+ L + + + + S D
Sbjct: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
Query: 298 RAFDAQSGELRRVFRGHTFIIN--CIQVHGQVLYTASHDGALRLWDVR 343
R +SG+ + FRGH+ +N G + +AS DG +++W+++
Sbjct: 332 RIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMK 379
Score = 47.0 bits (110), Expect = 3e-05
Identities = 27/98 (27%), Positives = 47/98 (47%), Gaps = 4/98 (4%)
Query: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV---TFCQLEDEAA 70
H G+ LS S D ++L+ S D T R+ G+ +GH S+V TF Q +
Sbjct: 306 HSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQ-DGHYI 364
Query: 71 FTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN 108
+ S+D T++ W++ T +C ++ S + N+
Sbjct: 365 ISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNS 402
Score = 33.1 bits (74), Expect = 0.42
Identities = 12/45 (26%), Positives = 23/45 (51%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQC 49
G L+ H +N + + DG +++ S DGT ++W+ +C
Sbjct: 339 GKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTEC 383
>gi|34996489 pleckstrin homology domain interacting protein [Homo
sapiens]
Length = 1821
Score = 89.7 bits (221), Expect = 4e-18
Identities = 85/350 (24%), Positives = 143/350 (40%), Gaps = 47/350 (13%)
Query: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
H + ++ G+R+ TGS+D ++W+T DG+ A L+GH + ++ + E
Sbjct: 182 HLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIA 241
Query: 74 SADCT--IRRWDVLTGQCLQVYRGHTSIVNRILVA------NNQLFSSSYDRTARVWSVD 125
+ C IR W + T L V +GH++ + + + L S+ D T W D
Sbjct: 242 AGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWD 301
Query: 126 KGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCC 185
G + R + P C+ +A G L TGSTD +V+ SG
Sbjct: 302 AGTLKINPRPAKFT------ERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQP 355
Query: 186 HQT--LRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEL 243
+ L HT V + + +GS D T R W F+ I L++
Sbjct: 356 EKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQ---------FKRREWKSILLDM 406
Query: 244 VNRLV---YSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAF 300
R G D+ K + T A R H T+ T + + +
Sbjct: 407 ATRPAGQNLQGIEDKITKMKV--------TMVAWDR-------HDNTVITAVNNMTLKVW 451
Query: 301 DAQSGELRRVFRGHTFIINCIQVHG---QVLYTASHDGALRLWDV-RGLR 346
++ +G+L V GH + ++ H +VL++A HDG + +WD+ RG++
Sbjct: 452 NSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVK 501
Score = 58.2 bits (139), Expect = 1e-08
Identities = 41/175 (23%), Positives = 72/175 (41%), Gaps = 22/175 (12%)
Query: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV--ICLEL 243
H+ + GH +V C+ D G FTGS D ++ W G L R H + + +
Sbjct: 176 HKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNY 235
Query: 244 VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGS----------G 293
N ++ +GS D+ ++ W T + H ++++L++ L +GS G
Sbjct: 236 ENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQF--SPLCSGSKRYLSSTGADG 293
Query: 294 DACARAFDAQSGEL--------RRVFRGHTFIINCIQVHGQVLYTASHDGALRLW 340
C +DA + ++ R G I + G L T S D +R++
Sbjct: 294 TICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVY 348
Score = 53.1 bits (126), Expect = 4e-07
Identities = 68/305 (22%), Positives = 109/305 (35%), Gaps = 52/305 (17%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVT--- 61
G L H I+ ++++ + + GS D R+W A+LQGH + +T
Sbjct: 215 GRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQ 274
Query: 62 ---FCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYR----------GHTSIVNRILVANN 108
C + AD TI W G R G I +
Sbjct: 275 FSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGM 334
Query: 109 QLFSSSYDRTARVWSVDKGQMSR--EFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLL 166
L + S D RV+ GQ + E H + V ++ +S
Sbjct: 335 FLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFS--------------NTSNRF 380
Query: 167 VTGSTDGTAKVWQ------------VASGCCHQTLRGHTG-----AVLCLVLDTPGHTAF 209
V+GS DGTA++WQ +A+ Q L+G V + D +T
Sbjct: 381 VSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVI 440
Query: 210 TGSTDATIRAWDILSGEQLRVFREHRGSVICLE---LVNRLVYSGSADRTVKCWLADTGE 266
T + T++ W+ +G+ + V H V LE R+++S D V W G
Sbjct: 441 TAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGV 500
Query: 267 CVRTF 271
+R++
Sbjct: 501 KIRSY 505
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 88.2 bits (217), Expect = 1e-17
Identities = 72/287 (25%), Positives = 117/287 (40%), Gaps = 31/287 (10%)
Query: 9 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 68
R H I + D + L++ S+DG +W + + S+V C
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 69 AAFTCSAD----CTIRRWDVLTGQCLQVYR---GHTSIVNRI-LVANNQLFSSSYDRTAR 120
+ C+I G ++V R GHT ++ + +NQ+ +SS D T
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGN-VRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA 167
Query: 121 VWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV 180
+W ++ GQ + F GH V++L+ + P T L V+G+ D +AK+W V
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLA-----PDTR---------LFVSGACDASAKLWDV 213
Query: 181 ASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVIC 240
G C QT GH + + G+ TGS DAT R +D+ + ++L + ++IC
Sbjct: 214 REGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY--SHDNIIC 271
Query: 241 ------LELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSAL 281
RL+ +G D W A + H VS L
Sbjct: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCL 318
Score = 82.0 bits (201), Expect = 8e-16
Identities = 73/270 (27%), Positives = 108/270 (40%), Gaps = 35/270 (12%)
Query: 85 LTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLA 144
L G ++Y H +R+LV S+S D +W + V+T A
Sbjct: 51 LRGHLAKIYAMHWGTDSRLLV------SASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCA 104
Query: 145 YSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASG----CCHQTLRGHTGAVLCL- 199
Y+ P A GGL D ++ + + + L GHTG + C
Sbjct: 105 YA--------PSGNYVACGGL------DNICSIYNLKTREGNVRVSRELAGHTGYLSCCR 150
Query: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTV 257
LD + T S D T WDI +G+Q F H G V+ L L RL SG+ D +
Sbjct: 151 FLDD--NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASA 208
Query: 258 KCWLADTGECVRTFTAHRRNVSALKY--HAGTLFTGSGDACARAFDAQSGELRRVFRGHT 315
K W G C +TFT H +++A+ + + TGS DA R FD ++ + +
Sbjct: 209 KLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDN 268
Query: 316 FIINCIQV----HGQVLYTASHDGALRLWD 341
I V G++L D +WD
Sbjct: 269 IICGITSVSFSKSGRLLLAGYDDFNCNVWD 298
Score = 73.9 bits (180), Expect = 2e-13
Identities = 60/235 (25%), Positives = 95/235 (40%), Gaps = 37/235 (15%)
Query: 24 SPDGQRLLTGSEDGTARLWS--TADG--QCCALLQGHESYVTFCQ-LEDEAAFTCSADCT 78
+P G + G D +++ T +G + L GH Y++ C+ L+D T S D T
Sbjct: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT 165
Query: 79 IRRWDVLTGQCLQVYRGHTS-IVNRILVANNQLF-SSSYDRTARVWSVDKGQMSREFRGH 136
WD+ TGQ + GHT +++ L + +LF S + D +A++W V +G + F GH
Sbjct: 166 CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH 225
Query: 137 RN----------------------CVL--------TLAYSAPWDLPSTPCAEEAAAGGLL 166
+ C L + YS + + +G LL
Sbjct: 226 ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLL 285
Query: 167 VTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 221
+ G D VW L GH V CL + G TGS D+ ++ W+
Sbjct: 286 LAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 69.7 bits (169), Expect = 4e-12
Identities = 61/222 (27%), Positives = 92/222 (41%), Gaps = 23/222 (10%)
Query: 131 REFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLR 190
R RGH L Y+ W S LLV+ S DG +W + +
Sbjct: 49 RTLRGH----LAKIYAMHWGTDSR----------LLVSASQDGKLIIWDSYTTNKVHAIP 94
Query: 191 GHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGE-QLRVFRE---HRGSVICLELVN- 245
+ V+ G+ G D +++ + E +RV RE H G + C ++
Sbjct: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD 154
Query: 246 RLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGT--LFTGSGDACARAFDAQ 303
+ + S D T W +TG+ TFT H +V +L T +G+ DA A+ +D +
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214
Query: 304 SGELRRVFRGHTFIIN--CIQVHGQVLYTASHDGALRLWDVR 343
G R+ F GH IN C +G T S D RL+D+R
Sbjct: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 256
Score = 34.7 bits (78), Expect = 0.14
Identities = 30/131 (22%), Positives = 49/131 (37%), Gaps = 18/131 (13%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS----------TADGQCCALLQ 54
G + H IN + P+G TGS+D T RL+ + D C +
Sbjct: 216 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITS 275
Query: 55 GHESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN--QLFS 112
S L F C+ WD L V GH + V+ + V ++ + +
Sbjct: 276 VSFSKSGRLLLAGYDDFNCNV------WDALKADRAGVLAGHDNRVSCLGVTDDGMAVAT 329
Query: 113 SSYDRTARVWS 123
S+D ++W+
Sbjct: 330 GSWDSFLKIWN 340
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 87.8 bits (216), Expect = 1e-17
Identities = 65/279 (23%), Positives = 112/279 (40%), Gaps = 29/279 (10%)
Query: 18 INWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV----------TFCQLED 67
I++ SP+ + L T G +LWS D L+GH + V +D
Sbjct: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293
Query: 68 EAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRIL--VANNQLFSSSYDRTARVWSVD 125
+C+AD +++ W + + + + GHT V R++ + L ++ YDR+ R+W ++
Sbjct: 294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353
Query: 126 KGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCC 185
+ GH V +A+ G L TG D +VW + +G C
Sbjct: 354 AQEEILHQEGHSMGVYDIAFHQD--------------GSLAGTGGLDAFGRVWDLRTGRC 399
Query: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLE--- 242
L GH + + G+ TGS D T + WD+ + H+ V ++
Sbjct: 400 IMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEP 459
Query: 243 LVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSAL 281
+ + +G+ D T K W ++T H V L
Sbjct: 460 IHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGL 498
Score = 72.8 bits (177), Expect = 5e-13
Identities = 55/200 (27%), Positives = 82/200 (41%), Gaps = 17/200 (8%)
Query: 25 PDGQRLLTGSEDGTARLWSTADGQCCALLQGHES--YVTFCQLEDEAAFTCSADCTIRRW 82
P G+ L T D + RLW + +GH Y + A T D R W
Sbjct: 333 PSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVW 392
Query: 83 DVLTGQCLQVYRGHTSIVNRILVANN--QLFSSSYDRTARVWSVDKGQMSREFRGHRNCV 140
D+ TG+C+ GH + I + N + + S D T +VW + + + H+N V
Sbjct: 393 DLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLV 452
Query: 141 LTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLV 200
+ + E G L+TG+ D TAK+W +TL GH G V+ L
Sbjct: 453 TGVKF-------------EPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLD 499
Query: 201 LDTPGHTAFTGSTDATIRAW 220
+ + G T S D T + W
Sbjct: 500 ISSDGQLIATCSYDRTFKLW 519
Score = 62.8 bits (151), Expect = 5e-10
Identities = 45/170 (26%), Positives = 69/170 (40%), Gaps = 19/170 (11%)
Query: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGH--ESYVTFCQLEDEAAF 71
H G+ ++ DG TG D R+W G+C L+GH E Y
Sbjct: 364 HSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIA 423
Query: 72 TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRIL---VANNQLFSSSYDRTARVWSVDKGQ 128
T S D T + WD+ +C+ H ++V + + N L + +YD TA++W+
Sbjct: 424 TGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWS 483
Query: 129 MSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVW 178
+ GH V+ L S+ G L+ T S D T K+W
Sbjct: 484 PLKTLAGHEGKVMGLDISSD--------------GQLIATCSYDRTFKLW 519
Score = 53.9 bits (128), Expect = 2e-07
Identities = 48/196 (24%), Positives = 77/196 (39%), Gaps = 14/196 (7%)
Query: 165 LLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLV--------LDTPGHTAFTGSTDAT 216
+L T G K+W V TLRGH V +V LD + + D +
Sbjct: 245 MLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGS 304
Query: 217 IRAWDILSGEQLRVFREH--RGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAH 274
++ W + S E + H R + + R + + DR+ + W + E + H
Sbjct: 305 VKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGH 364
Query: 275 RRNVSALKYHAGTLFTGSG--DACARAFDAQSGELRRVFRGHTFIINCIQV--HGQVLYT 330
V + +H G+G DA R +D ++G GH I I +G + T
Sbjct: 365 SMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIAT 424
Query: 331 ASHDGALRLWDVRGLR 346
S D ++WD+R R
Sbjct: 425 GSGDNTCKVWDLRQRR 440
Score = 50.1 bits (118), Expect = 3e-06
Identities = 32/126 (25%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVT--- 61
G + H I ++ SP+G + TGS D T ++W +C + H++ VT
Sbjct: 397 GRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVK 456
Query: 62 FCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHT-SIVNRILVANNQLFSS-SYDRTA 119
F + T + D T + W L+ GH ++ + ++ QL ++ SYDRT
Sbjct: 457 FEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTF 516
Query: 120 RVWSVD 125
++W +
Sbjct: 517 KLWMAE 522
Score = 35.0 bits (79), Expect = 0.11
Identities = 17/39 (43%), Positives = 22/39 (56%)
Query: 4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLW 42
G S L+ A H G + L +S DGQ + T S D T +LW
Sbjct: 481 GWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 87.0 bits (214), Expect = 2e-17
Identities = 60/220 (27%), Positives = 88/220 (40%), Gaps = 23/220 (10%)
Query: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQG----HESYVTFCQ-LEDE 68
H G ++ S S DG L TG D + W + L+ H +VT C +D
Sbjct: 2060 HEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDN 2119
Query: 69 AAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQ 128
+CS+D ++ WD +GQ L + GH S V+ + + S S D T +VW
Sbjct: 2120 LLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWD----- 2174
Query: 129 MSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGG------LLVTGSTDGTAKVWQVAS 182
H+ LT + + A E A G L+VT DG ++W
Sbjct: 2175 -------HQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLL 2227
Query: 183 GCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
C TL GH+G V + T S D ++R W +
Sbjct: 2228 VCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQV 2267
Score = 68.2 bits (165), Expect = 1e-11
Identities = 90/389 (23%), Positives = 141/389 (36%), Gaps = 76/389 (19%)
Query: 18 INWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTF-------CQLEDEAA 70
I L+ + G + G D LW+ +G A H +V CQL
Sbjct: 1845 IRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQL----- 1899
Query: 71 FTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTA--------RVW 122
T D ++ W G+ RGH ++ + A + S DR A R++
Sbjct: 1900 LTAGEDGKVQVWSGSLGRP----RGHLGSLS-LSPALSVALSPDGDRVAVGYRADGIRIY 1954
Query: 123 SVDKGQMSREFRGHRNCVLTLAYSAP--------------WDLPST-------------P 155
+ G + + V LA+ +P W L P
Sbjct: 1955 KISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKP 2014
Query: 156 CAEEAAAGGLLVTGSTDGTAKVW---------QVASGCCHQTLRGHTGAVLCLVLDTPGH 206
A + LL + S D T ++W + C LRGH G V C T G
Sbjct: 2015 VLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGG 2074
Query: 207 TAFTGSTDATIRAWDILSGEQLRVFRE----HRGSVI-CLELVNRLVYSGSADRTVKCWL 261
+ TG D ++ WD+ + + + HR V C + L+ S S+D +V W
Sbjct: 2075 SLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWD 2134
Query: 262 ADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCI 321
++G+ + F H+ VSA+ + + S D + +D Q EL + I +C
Sbjct: 2135 PESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCA 2194
Query: 322 -----QVHGQ-----VLYTASHDGALRLW 340
+ GQ ++ T DGA RLW
Sbjct: 2195 AAMEPRAAGQPGSELLVVTVGLDGATRLW 2223
Score = 47.8 bits (112), Expect = 2e-05
Identities = 70/338 (20%), Positives = 125/338 (36%), Gaps = 36/338 (10%)
Query: 21 LSLSPDGQRLLTGSEDGTARLWSTADGQC-CALLQGHESYVTFCQLEDEAAFTCSADCTI 79
++ S +GQR G+ +GT L Q +++ G + L D+ F + D +
Sbjct: 1682 VAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLL 1741
Query: 80 RRWDVLTG-QCLQVYRGHTSIVNRILVANNQLFSS-SYDRTARVWSVDKGQMSREFRGHR 137
WD+ G + LQ I L + +L ++ ++W +GQ
Sbjct: 1742 ELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ--------- 1792
Query: 138 NCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVL 197
L ++ P S C G ++ TGS G+ +QV + L ++
Sbjct: 1793 ---LAFQHTYP---KSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIR 1846
Query: 198 CLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSV---ICLELVNRLVYSGSAD 254
L + PG G D+ + W G +L F H G V + L +L+ +G D
Sbjct: 1847 TLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGE-D 1905
Query: 255 RTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRG- 313
V+ W G H ++S L + GD A + A + ++ G
Sbjct: 1906 GKVQVWSGSLGRP----RGHLGSLS-LSPALSVALSPDGDRVAVGYRADGIRIYKISSGS 1960
Query: 314 --------HTFIINCIQVHGQVLYTASHDGALRLWDVR 343
+ + +VL + + DG+L+ W ++
Sbjct: 1961 QGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALK 1998
Score = 40.8 bits (94), Expect = 0.002
Identities = 46/180 (25%), Positives = 75/180 (41%), Gaps = 10/180 (5%)
Query: 199 LVLDTPGHTAFTGSTDATIRAWDILSG-EQLRVFREHRGSVICLELVNRLVYSGSADRTV 257
+ T G A G+ + T+ D+ + E+ V G CL L + ++ + D +
Sbjct: 1682 VAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLL 1741
Query: 258 KCWLADTGECVRTFTAHRRNVSA--LKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHT 315
+ W G V AH+ ++ L L T C + +D G+L F+ HT
Sbjct: 1742 ELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQL--AFQ-HT 1798
Query: 316 F--IINCIQVH--GQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSRLFSNKVGCAAA 371
+ +NC+ H GQV+ T S G++ + V GL+ P S+ L N G A
Sbjct: 1799 YPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVA 1858
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 87.0 bits (214), Expect = 2e-17
Identities = 89/377 (23%), Positives = 146/377 (38%), Gaps = 56/377 (14%)
Query: 6 SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL 65
S L V H + L+ S DG +L+ D +W Q + ES L
Sbjct: 186 SCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLL 245
Query: 66 EDEAA------------FTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQ- 109
+E T T+R W+ +GQC+ G + +A+
Sbjct: 246 PEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAG 305
Query: 110 -LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVT 168
+ +++ D ++ ++ ++F G+ VL + + P D +V
Sbjct: 306 VVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPED-------------SHVVV 352
Query: 169 GSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL 228
S KV+++ + C Q L GHT VL L + G + + D ++R W + Q+
Sbjct: 353 ASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQV 411
Query: 229 RVFREHR------GSVICLELVNRLVYSGSADRTVKCW-----------LADTG----EC 267
+ G+V C L + +GS D TVK W D G +
Sbjct: 412 MCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQA 471
Query: 268 VRTFTAHRRNVS--ALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH- 324
T H ++++ A+ + L TGS D A+ + +L VF GH + C+Q
Sbjct: 472 QTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSP 531
Query: 325 -GQVLYTASHDGALRLW 340
QVL TAS DG ++LW
Sbjct: 532 MDQVLATASADGTIKLW 548
Score = 85.1 bits (209), Expect = 9e-17
Identities = 80/293 (27%), Positives = 120/293 (40%), Gaps = 28/293 (9%)
Query: 23 LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF--TCSADCTIR 80
L P+ ++ S +++ C +L GH V + + +C+ D ++R
Sbjct: 343 LGPEDSHVVVASNSPCLKVFELQTS-ACQILHGHTDIVLALDVFRKGWLFASCAKDQSVR 401
Query: 81 RWDV-LTGQ--CLQVYRGHTSIVNRILVANNQ---LFSSSYDRTARVWSVDKGQMSREFR 134
W + GQ C+ GHT V + + + L + S D T ++W + K +S+
Sbjct: 402 IWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTA 461
Query: 135 GHRNCVLTLAYSAPW----DLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLR 190
+L A + D+ S A LL TGS D TAK+W +
Sbjct: 462 PDNGPILLQAQTTQRCHDKDINSVAIAPNDK---LLATGSQDRTAKLWALPQCQLLGVFS 518
Query: 191 GHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR---L 247
GH + C+ T S D TI+ W + L+ F H SV+ + V+R L
Sbjct: 519 GHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQL 578
Query: 248 VYSGSADRTVKCWLADTGECVRTFTAHRRNV-----SALKYHAGTLFTGSGDA 295
+ SGS D VK W ECVRT AH V S L HA TG+ D+
Sbjct: 579 LSSGS-DGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHA---LTGASDS 627
Score = 84.3 bits (207), Expect = 2e-16
Identities = 69/280 (24%), Positives = 116/280 (41%), Gaps = 39/280 (13%)
Query: 6 SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLW---STADGQCCALLQGHESYV-T 61
SA ++ H + L + G + ++D + R+W C A GH V T
Sbjct: 367 SACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGT 426
Query: 62 FC--QLEDEAAFTCSADCTIRRWDV---------------LTGQCLQVYRGHTSIVNRIL 104
C +L++ T S DCT++ W + + Q R H +N +
Sbjct: 427 VCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVA 486
Query: 105 VANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAA 162
+A N L + S DRTA++W++ + Q+ F GHR + W C + +
Sbjct: 487 IAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGL--------W------CVQFSPM 532
Query: 163 GGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
+L T S DGT K+W + C +T GH +VL + + G + +D ++ W I
Sbjct: 533 DQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTI 592
Query: 223 LSGEQLRVFREHRGSVICLEL--VNRLVYSGSADRTVKCW 260
+ E +R H V L ++ +G++D V W
Sbjct: 593 KNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Score = 80.5 bits (197), Expect = 2e-15
Identities = 91/398 (22%), Positives = 150/398 (37%), Gaps = 90/398 (22%)
Query: 18 INWLSLSPDGQRLLTGSEDGTARLWSTADGQCC---ALLQGHESYVTFCQL--------- 65
++ L + G LT + GT R+W A GQC A G +T C L
Sbjct: 250 VSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLT 309
Query: 66 ------------------------------------EDEAAFTCSADCTIRRWDVLTGQC 89
ED S ++ +++ T C
Sbjct: 310 ATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC 369
Query: 90 LQVYRGHTSIVNRI-LVANNQLFSS-SYDRTARVWSVDK-GQMS--REFRGHRNCVLTLA 144
Q+ GHT IV + + LF+S + D++ R+W ++K GQ+ + GH + V T+
Sbjct: 370 -QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVC 428
Query: 145 YSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC---------------CHQTL 189
S LVTGS D T K+W + T
Sbjct: 429 CS-------------RLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQ 475
Query: 190 RGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEL--VNRL 247
R H + + + TGS D T + W + + L VF HR + C++ ++++
Sbjct: 476 RCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQV 535
Query: 248 VYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKY-HAGTLFTGSG-DACARAFDAQSG 305
+ + SAD T+K W C++TF H +V + + GT SG D + + ++
Sbjct: 536 LATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNN 595
Query: 306 ELRRVFRGH---TFIINCIQVHGQVLYTASHDGALRLW 340
E R H + ++C ++ L T + D + LW
Sbjct: 596 ECVRTLDAHEDKVWGLHCSRLDDHAL-TGASDSRVILW 632
Score = 64.7 bits (156), Expect = 1e-10
Identities = 86/362 (23%), Positives = 136/362 (37%), Gaps = 36/362 (9%)
Query: 5 GSALRVC-ADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFC 63
GS R+ A H + ++ P L TG DG R+W +G V
Sbjct: 98 GSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLV 157
Query: 64 QLEDEAA----FTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDR 117
+ F+ + D IR W + CL V H S V + + + + SS D+
Sbjct: 158 AFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDK 217
Query: 118 TARVWSVDKGQMSRE---FRGHRNCVLTLAYSAPWDLPSTPCAE--EAAAGGLLVTGSTD 172
+W + Q +R F VL LP P ++ + G +T
Sbjct: 218 ICIIWDLQSCQATRTVPVFESVEAAVL---------LPEEPVSQLGVKSPGLYFLTAGDQ 268
Query: 173 GTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTA---FTGSTDATIRAWDILSGEQLR 229
GT +VW+ ASG C T G L T HTA T + D + ++ S +
Sbjct: 269 GTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQK 328
Query: 230 VFREHRGSVICLELV---NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALK-YHA 285
F + V+ + + + V S +K + T C + H V AL +
Sbjct: 329 QFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRK 387
Query: 286 GTLFTG-SGDACARAFDA-QSGELRRVFR--GHTFIIN---CIQVHGQVLYTASHDGALR 338
G LF + D R + ++G++ V + GHT + C ++ L T S D ++
Sbjct: 388 GWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVK 447
Query: 339 LW 340
LW
Sbjct: 448 LW 449
Score = 63.5 bits (153), Expect = 3e-10
Identities = 63/271 (23%), Positives = 106/271 (39%), Gaps = 34/271 (12%)
Query: 66 EDEAAFTCSADCTIRRWDVLTGQCLQVYRG-HTSIVNRILV--ANNQLFSSSYDRTARVW 122
++E T S + +W G ++++ HT+ V + + L + D RVW
Sbjct: 77 DNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVW 136
Query: 123 SVDKGQMSREFRGHRNCVLTLAYSA-PWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181
+ + + FRG V +A+ P L LL + +TD +VW +
Sbjct: 137 DIVRHYGTHHFRGSPGVVHLVAFHPDPTRL-------------LLFSSATDAAIRVWSLQ 183
Query: 182 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLR---VFREHRGSV 238
C L H AV L GHT + D WD+ S + R VF +V
Sbjct: 184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAV 243
Query: 239 IC-LELVNRL--------VYSGSADRTVKCWLADTGECVRTFT-----AHRRNVSALKYH 284
+ E V++L + T++ W A +G+CV T L +
Sbjct: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
Query: 285 AGTLFTGSGDACARAFDAQSGELRRVFRGHT 315
AG + T + D ++A+S L++ F G++
Sbjct: 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYS 334
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.135 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,281,250
Number of Sequences: 37866
Number of extensions: 773447
Number of successful extensions: 6064
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 228
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 2182
Number of HSP's gapped (non-prelim): 1697
length of query: 376
length of database: 18,247,518
effective HSP length: 104
effective length of query: 272
effective length of database: 14,309,454
effective search space: 3892171488
effective search space used: 3892171488
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.