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Search of human proteins with 110347455
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110347455 Brn3b POU domain transcription factor [Homo
sapiens]
(409 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110347455 Brn3b POU domain transcription factor [Homo sapiens] 832 0.0
gi|4505965 POU class 4 homeobox 3 [Homo sapiens] 451 e-127
gi|110347449 POU domain, class 4, transcription factor 1 [Homo s... 321 9e-88
gi|51702521 POU domain, class 3, transcription factor 2 [Homo sa... 188 9e-48
gi|5453936 POU class 3 homeobox 3 [Homo sapiens] 178 9e-45
gi|110624765 POU domain, class 3, transcription factor 1 [Homo s... 169 4e-42
gi|110624763 POU domain, class 3, transcription factor 4 [Homo s... 151 9e-37
gi|148664218 POU transcription factor [Homo sapiens] 145 8e-35
gi|170650730 pituitary specific transcription factor 1 isoform b... 135 7e-32
gi|4505955 pituitary specific transcription factor 1 isoform alp... 135 7e-32
gi|42476164 POU class 2 homeobox 1 [Homo sapiens] 132 6e-31
gi|4505959 POU domain, class 2, transcription factor 2 [Homo sap... 131 1e-30
gi|116235491 POU domain, class 5, transcription factor 1 isoform... 129 4e-30
gi|42560248 POU domain, class 5, transcription factor 1 isoform ... 129 4e-30
gi|227430410 POU class 5 homeobox 1B [Homo sapiens] 124 2e-28
gi|223890225 POU class 6 homeobox 1 [Homo sapiens] 113 3e-25
gi|23463326 POU domain class 5, transcription factor 2 [Homo sap... 100 4e-21
gi|157743257 POU domain, class 6, transcription factor 2 [Homo s... 98 1e-20
gi|119220564 one cut domain, family member 2 [Homo sapiens] 82 9e-16
gi|71274111 v-maf musculoaponeurotic fibrosarcoma oncogene homol... 75 1e-13
gi|84105335 mesenchyme homeobox 2 [Homo sapiens] 62 7e-10
gi|20070107 orthodenticle homeobox 1 [Homo sapiens] 62 1e-09
gi|6912752 zinc finger protein 281 [Homo sapiens] 60 3e-09
gi|239757043 PREDICTED: functional smad suppressing element 18 [... 59 6e-09
gi|239751555 PREDICTED: functional smad suppressing element 18 [... 59 6e-09
gi|239746067 PREDICTED: functional smad suppressing element 18 [... 59 6e-09
gi|4507163 SRY (sex determining region Y)-box 4 [Homo sapiens] 59 1e-08
gi|238859557 regulatory factor X1 [Homo sapiens] 57 2e-08
gi|4826734 fusion (involved in t(12;16) in malignant liposarcoma... 57 3e-08
gi|33620755 YEATS domain containing 2 [Homo sapiens] 57 3e-08
>gi|110347455 Brn3b POU domain transcription factor [Homo sapiens]
Length = 409
Score = 832 bits (2149), Expect = 0.0
Identities = 409/409 (100%), Positives = 409/409 (100%)
Query: 1 MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGG 60
MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGG
Sbjct: 1 MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGG 60
Query: 61 GGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIV 120
GGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIV
Sbjct: 61 GGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIV 120
Query: 121 SQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHH 180
SQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHH
Sbjct: 121 SQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHH 180
Query: 181 HHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHG 240
HHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHG
Sbjct: 181 HHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHG 240
Query: 241 LPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTIC 300
LPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTIC
Sbjct: 241 LPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTIC 300
Query: 301 RFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSL 360
RFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSL
Sbjct: 301 RFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSL 360
Query: 361 EAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI 409
EAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
Sbjct: 361 EAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI 409
>gi|4505965 POU class 4 homeobox 3 [Homo sapiens]
Length = 338
Score = 451 bits (1161), Expect = e-127
Identities = 237/335 (70%), Positives = 268/335 (80%), Gaps = 25/335 (7%)
Query: 78 SSGGGGSEAMRRACLPTPP--SNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSP 135
SS GSEAMRR CLP P NIFG DESLLARAEALAAVDIVS K+H P
Sbjct: 22 SSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEALAAVDIVSHGKNH--------P 73
Query: 136 FKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEH 195
FKPDATYHTM+++PCTS +SS+VPISHP+AL H HH HQ LEG+LLEH
Sbjct: 74 FKPDATYHTMSSVPCTS--TSSTVPISHPAALTS---------HPHHAVHQGLEGDLLEH 122
Query: 196 LSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMG---CMSDVD 252
+SP L++ + P+ +V+ H H+ M +HQA + M+H H + H C+SDV+
Sbjct: 123 ISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQA-MGMSHPHTVAPHSAMPACLSDVE 181
Query: 253 ADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNM 312
+DPR+LEAFAERFKQRRIKLGVTQADVG+ALANLKIPGVGSLSQSTICRFESLTLSHNNM
Sbjct: 182 SDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFESLTLSHNNM 241
Query: 313 IALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSS 372
IALKP+LQAWLEEAE ++REK +KPELFNG+E+KRKRTSIAAPEKRSLEAYFAIQPRPSS
Sbjct: 242 IALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPSS 301
Query: 373 EKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSA 407
EKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSA
Sbjct: 302 EKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSA 336
>gi|110347449 POU domain, class 4, transcription factor 1 [Homo
sapiens]
Length = 419
Score = 321 bits (822), Expect = 9e-88
Identities = 199/387 (51%), Positives = 219/387 (56%), Gaps = 88/387 (22%)
Query: 21 HVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSG 80
H+ AL + + G+ A + G GGGGG GGG GGG G G
Sbjct: 119 HISSPSLALMAGAGGAGAAAGGGGAHDGPGGGGGPGGGGGPGGGPGGG-----GGGGPGG 173
Query: 81 GGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDA 140
GGG P + GG S H HP HS
Sbjct: 174 GGGG----------PGGGLLGG----------------------SAHPHPHMHS------ 195
Query: 141 TYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGL 200
H + P +AA + + HP +A HH G
Sbjct: 196 LGHLSH--PAAAAAMNMPSGLPHPGLVAAAAHH-------------------------GA 228
Query: 201 ALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEA 260
A A A G V + AA ++ A GL S + D D DPR+LEA
Sbjct: 229 AAAAAAAAAGQVAAA--------------SAAAAVVGAAGLAS----ICDSDTDPRELEA 270
Query: 261 FAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQ 320
FAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQ
Sbjct: 271 FAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQ 330
Query: 321 AWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAE 380
AWLEEAE + REK+ KPELFNG EKKRKRTSIAAPEKRSLEAYFA+QPRPSSEKIAAIAE
Sbjct: 331 AWLEEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAE 390
Query: 381 KLDLKKNVVRVWFCNQRQKQKRMKYSA 407
KLDLKKNVVRVWFCNQRQKQKRMK+SA
Sbjct: 391 KLDLKKNVVRVWFCNQRQKQKRMKFSA 417
Score = 137 bits (344), Expect = 2e-32
Identities = 83/133 (62%), Positives = 95/133 (71%), Gaps = 30/133 (22%)
Query: 84 SEAMRRACLPTPP--SNIFGGLDESLLARAEALAAVDI-VSQSKSHHHHPPHHSPFKPDA 140
SEA+RRACLPTPP SN+F LDE+LLARAEALAAVDI VSQ KSH PFKPDA
Sbjct: 29 SEAIRRACLPTPPLQSNLFASLDETLLARAEALAAVDIAVSQGKSH--------PFKPDA 80
Query: 141 TYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALE-GELLEHL-SP 198
TYHTMN++PCT S+S+VP++H HHHHHHH HQALE G+LL+H+ SP
Sbjct: 81 TYHTMNSVPCT---STSTVPLAH-------HHHHHHH-------HQALEPGDLLDHISSP 123
Query: 199 GLALGAMAGPDGA 211
LAL A AG GA
Sbjct: 124 SLALMAGAGGAGA 136
>gi|51702521 POU domain, class 3, transcription factor 2 [Homo
sapiens]
Length = 443
Score = 188 bits (477), Expect = 9e-48
Identities = 145/418 (34%), Positives = 189/418 (45%), Gaps = 72/418 (17%)
Query: 22 VEPKYSALHSTS-PGSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSG--- 77
V+ Y AL S P S A +A S GGGGGGGGGGGGGGG S S+S
Sbjct: 41 VQGDYGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQ 100
Query: 78 ---------SSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHH 128
GG G E L P G L + + + Q +
Sbjct: 101 PDIKPSVVVQQGGRGDE------LHGP-----GALQQQHQQQQQQQQQQQQQQQQQQQQQ 149
Query: 129 HPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQAL 188
PPH +H N P A S++ P ++ ++
Sbjct: 150 RPPH-------LVHHAANHHPGPGAWRSAAAAAHLPPSMGASN----------------- 185
Query: 189 EGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAH--------- 239
G LL + P + M G G H A P H H+H
Sbjct: 186 -GGLL-YSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPP 243
Query: 240 ---GLPSHMGCMSDVDADPR-----DLEAFAERFKQRRIKLGVTQADVGSALANLKIPGV 291
G P H G D +D DLE FA++FKQRRIKLG TQADVG AL L
Sbjct: 244 PPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTL----Y 299
Query: 292 GSL-SQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRT 350
G++ SQ+TICRFE+L LS NM LKP+L WLEEA+ S + ++ K++KRT
Sbjct: 300 GNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRT 359
Query: 351 SIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAG 408
SI K +LE++F P+PS+++I ++A+ L L+K VVRVWFCN+RQK+KRM G
Sbjct: 360 SIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGG 417
>gi|5453936 POU class 3 homeobox 3 [Homo sapiens]
Length = 500
Score = 178 bits (451), Expect = 9e-45
Identities = 136/417 (32%), Positives = 182/417 (43%), Gaps = 58/417 (13%)
Query: 3 MMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGGGG 62
M+S + ++PH + +A+ ++SP S + + A SP G
Sbjct: 90 MLSHAHQWVTALPHAAAAAAAAAAAAVEASSPWSGSAVG-MAGSPQQPPQPPPPPPQGPD 148
Query: 63 GGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVS- 121
GG GR + + G P P GG + A A A AA
Sbjct: 149 VKGGAGRDDLHAGTALHHRGPPHLGPPP--PPPHQGHPGGWGAAAAAAAAAAAAAAAAHL 206
Query: 122 QSKSHHHHPPHHSPFKPDATYHTMNTIPCT--------SAASSSSVPISHPSALAGT--- 170
S + PP S T+N + A + + HP + G
Sbjct: 207 PSMAGGQQPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPE 266
Query: 171 ---HHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNP 227
HHHHHHHH H H PH PH A P
Sbjct: 267 LAEHHHHHHHHAHPHPPH----------------------------------PHHA-QGP 291
Query: 228 MHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLK 287
H GL SH + DLE FA++FKQRRIKLG TQADVG AL L
Sbjct: 292 PHHGGGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTL- 350
Query: 288 IPGVGSL-SQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKK 346
G++ SQ+TICRFE+L LS NM LKP+L WLEEA+ S + ++ K+
Sbjct: 351 ---YGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKR 407
Query: 347 RKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRM 403
+KRTSI K +LE++F P+PS+++I +A+ L L+K VVRVWFCN+RQK+KRM
Sbjct: 408 KKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRM 464
Score = 47.8 bits (112), Expect = 2e-05
Identities = 29/69 (42%), Positives = 38/69 (55%), Gaps = 12/69 (17%)
Query: 34 PGSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGG---GSEAMRRA 90
PG+S +A + S ++ AGGGGGGGGGGGGGG +G GGG GS A+
Sbjct: 11 PGNSL-LAAGSIVHSDAAGAGGGGGGGGGGGGGG--------AGGGGGGMQPGSAAVTSG 61
Query: 91 CLPTPPSNI 99
PS++
Sbjct: 62 AYRGDPSSV 70
>gi|110624765 POU domain, class 3, transcription factor 1 [Homo
sapiens]
Length = 451
Score = 169 bits (428), Expect = 4e-42
Identities = 146/411 (35%), Positives = 190/411 (46%), Gaps = 67/411 (16%)
Query: 16 HGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGGGGG---------GGG 66
H G+ + E + +H G+ A + P GGGGG GG GGG
Sbjct: 41 HAGAAYREVQ-KLMHHEWLGAGAGHPVGLAHPQWLPTGGGGGGDWAGGPHLEHGKAGGGG 99
Query: 67 GGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSH 126
GR+ GGGG GG L+ + A A +Q +
Sbjct: 100 TGRADD-------GGGG-----------------GGFHARLVHQGAAHAGA-AWAQGSTA 134
Query: 127 HHHPPHHSPFKPDATYHTMNTIPCTSAAS---SSSVPISHPSALAGTHHHHHHHHHHHHQ 183
HH P SP + H + + A+ ++ A G HH H
Sbjct: 135 HHLGPAMSPSPGASGGHQPQPLGLYAQAAYPGGGGGGLAGMLAAGGGGAGPGLHHALHED 194
Query: 184 PHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAH---- 239
H+A LE SP LGA HA A +H AA AH H
Sbjct: 195 GHEAQ----LEP-SPPPHLGAHG-----------HAHGHAHAGGLHAAA---AHLHPGAG 235
Query: 240 GLPSHMGCMSDVDADPRD-LEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSL-SQS 297
G S +G SD DA D LE FA++FKQRRIKLG TQADVG AL L G++ SQ+
Sbjct: 236 GGGSSVGEHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTL----YGNVFSQT 291
Query: 298 TICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEK 357
TICRFE+L LS NM LKP+L WLEE + S ++ K++KRTSI K
Sbjct: 292 TICRFEALQLSFKNMCKLKPLLNKWLEETDSSSGSPTNLDKIAAQGRKRKKRTSIEVGVK 351
Query: 358 RSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAG 408
+LE++F P+PS+ +I +A+ L L+K VVRVWFCN+RQK+KRM +AG
Sbjct: 352 GALESHFLKCPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRMTPAAG 402
Score = 31.6 bits (70), Expect = 1.4
Identities = 30/111 (27%), Positives = 38/111 (34%), Gaps = 4/111 (3%)
Query: 68 GRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHH 127
GR +S G G+ P P ++ GL +SL E + + K
Sbjct: 337 GRKRKKRTSIEVGVKGALESHFLKCPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKR 396
Query: 128 HHPPHHSPFKP-DATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHH 177
P + P D Y P AS S P P A HHHHHH
Sbjct: 397 MTPAAGAGHPPMDDVYAPGELGPGGGGASPPSAPPPPPPAAL---HHHHHH 444
>gi|110624763 POU domain, class 3, transcription factor 4 [Homo
sapiens]
Length = 361
Score = 151 bits (382), Expect = 9e-37
Identities = 103/274 (37%), Positives = 138/274 (50%), Gaps = 31/274 (11%)
Query: 151 TSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQ----------------ALEGELLE 194
TS V G HH H HH PH G+ L
Sbjct: 73 TSPLDQQDVKPGREDLQLGAIIHHRSPHVAHHSPHTNHPNAWGASPAPNPSITSSGQPLN 132
Query: 195 HLS-PGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDA 253
S PG + M G ++ P A +++P+ L HG C D
Sbjct: 133 VYSQPGFTVSGMLEHGG--LTPPPAAASAQSLHPV----LREPPDHGELGSHHCQDHSDE 186
Query: 254 DPR---DLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSL-SQSTICRFESLTLSH 309
+ +LE FA++FKQRRIKLG TQADVG AL L G++ SQ+TICRFE L LS
Sbjct: 187 ETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTL----YGNVFSQTTICRFEGLQLSF 242
Query: 310 NNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPR 369
NM LKP+L WLEEA+ S + ++ K++KRTSI K LE +F P+
Sbjct: 243 KNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGVLETHFLKCPK 302
Query: 370 PSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRM 403
P++++I+++A+ L L+K VVRVWFCN+RQK+KRM
Sbjct: 303 PAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRM 336
>gi|148664218 POU transcription factor [Homo sapiens]
Length = 436
Score = 145 bits (365), Expect = 8e-35
Identities = 94/224 (41%), Positives = 127/224 (56%), Gaps = 21/224 (9%)
Query: 186 QALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHM 245
Q G LL PGLA A P P +++ P +A+ + LPS
Sbjct: 131 QQQSGLLLPQTGPGLASQAFGHP-----GLPG-----SSLEPHLEASQHLPVPKHLPSSG 180
Query: 246 GCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESL 305
G +D +D +LE FA+ FKQRRIKLG TQ DVG A+ L SQ+TI RFE+L
Sbjct: 181 G--ADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLY---GNDFSQTTISRFEAL 235
Query: 306 TLSHNNMIALKPILQAWLEEAEKSHRE-KLTKPELFNG-----AEKKRKRTSIAAPEKRS 359
LS NM LKP+L+ WL +AE S + ++ P + K++KRTSI + +
Sbjct: 236 NLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRKKRTSIETNIRLT 295
Query: 360 LEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRM 403
LE F P+PSSE+I+ IAE+L ++K VVRVWFCN+RQK+KR+
Sbjct: 296 LEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRI 339
>gi|170650730 pituitary specific transcription factor 1 isoform beta
[Homo sapiens]
Length = 317
Score = 135 bits (340), Expect = 7e-32
Identities = 81/162 (50%), Positives = 110/162 (67%), Gaps = 14/162 (8%)
Query: 250 DVDA-DPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGS-LSQSTICRFESLTL 307
D+D+ + R+LE FA FK RRIKLG TQ +VG ALA + GS SQ+TICRFE+L L
Sbjct: 149 DMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVH----GSEFSQTTICRFENLQL 204
Query: 308 SHNNMIALKPILQAWLEEAEKS---HREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYF 364
S N LK IL WLEEAE+ + EK+ E K+++RT+I+ K +LE +F
Sbjct: 205 SFKNACKLKAILSKWLEEAEQVGALYNEKVGANE-----RKRKRRTTISIAAKDALERHF 259
Query: 365 AIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYS 406
Q +PSS++I +AE+L+L+K VVRVWFCN+RQ++KR+K S
Sbjct: 260 GEQNKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTS 301
>gi|4505955 pituitary specific transcription factor 1 isoform alpha
[Homo sapiens]
Length = 291
Score = 135 bits (340), Expect = 7e-32
Identities = 81/162 (50%), Positives = 110/162 (67%), Gaps = 14/162 (8%)
Query: 250 DVDA-DPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGS-LSQSTICRFESLTL 307
D+D+ + R+LE FA FK RRIKLG TQ +VG ALA + GS SQ+TICRFE+L L
Sbjct: 123 DMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVH----GSEFSQTTICRFENLQL 178
Query: 308 SHNNMIALKPILQAWLEEAEKS---HREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYF 364
S N LK IL WLEEAE+ + EK+ E K+++RT+I+ K +LE +F
Sbjct: 179 SFKNACKLKAILSKWLEEAEQVGALYNEKVGANE-----RKRKRRTTISIAAKDALERHF 233
Query: 365 AIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYS 406
Q +PSS++I +AE+L+L+K VVRVWFCN+RQ++KR+K S
Sbjct: 234 GEQNKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTS 275
>gi|42476164 POU class 2 homeobox 1 [Homo sapiens]
Length = 743
Score = 132 bits (332), Expect = 6e-31
Identities = 80/204 (39%), Positives = 115/204 (56%), Gaps = 15/204 (7%)
Query: 208 PDGAVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMS-DVDADPRDLEAFAERFK 266
P + S PA P+ ++ + P + S + +D +LE FA+ FK
Sbjct: 241 PSITLTSQPATPTRTIAATPIQ----TLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFK 296
Query: 267 QRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEA 326
QRRIKLG TQ DVG A+ L SQ+TI RFE+L LS NM LKP+L+ WL +A
Sbjct: 297 QRRIKLGFTQGDVGLAMGKLY---GNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDA 353
Query: 327 EK-SHREKLTKPELFNG------AEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIA 379
E S L+ P N + +++KRTSI + +LE F +P+SE+I IA
Sbjct: 354 ENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIA 413
Query: 380 EKLDLKKNVVRVWFCNQRQKQKRM 403
++L+++K V+RVWFCN+RQK+KR+
Sbjct: 414 DQLNMEKEVIRVWFCNRRQKEKRI 437
>gi|4505959 POU domain, class 2, transcription factor 2 [Homo
sapiens]
Length = 463
Score = 131 bits (329), Expect = 1e-30
Identities = 79/172 (45%), Positives = 107/172 (62%), Gaps = 17/172 (9%)
Query: 242 PSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICR 301
PSH SD++ +LE FA FKQRRIKLG TQ DVG A+ L SQ+TI R
Sbjct: 175 PSHPEEPSDLE----ELEQFARTFKQRRIKLGFTQGDVGLAMGKLY---GNDFSQTTISR 227
Query: 302 FESLTLSHNNMIALKPILQAWLEEAEKSHRE-------KLTKPEL-FNG--AEKKRKRTS 351
FE+L LS NM LKP+L+ WL +AE + +L+ P L F+G +++KRTS
Sbjct: 228 FEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTS 287
Query: 352 IAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRM 403
I + +LE F +P+SE+I IAE+L ++K V+RVWFCN+RQK+KR+
Sbjct: 288 IETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRI 339
>gi|116235491 POU domain, class 5, transcription factor 1 isoform 2
[Homo sapiens]
Length = 265
Score = 129 bits (325), Expect = 4e-30
Identities = 76/155 (49%), Positives = 105/155 (67%), Gaps = 7/155 (4%)
Query: 250 DVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSL-SQSTICRFESLTLS 308
D+ A ++LE FA+ KQ+RI LG TQADVG L L G + SQ+TICRFE+L LS
Sbjct: 43 DIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVL----FGKVFSQTTICRFEALQLS 98
Query: 309 HNNMIALKPILQAWLEEAEKSHR-EKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQ 367
NM L+P+LQ W+EEA+ + +++ K E A +KRKRTSI + +LE F
Sbjct: 99 FKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQA-RKRKRTSIENRVRGNLENLFLQC 157
Query: 368 PRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKR 402
P+P+ ++I+ IA++L L+K+VVRVWFCN+RQK KR
Sbjct: 158 PKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKR 192
>gi|42560248 POU domain, class 5, transcription factor 1 isoform 1
[Homo sapiens]
Length = 360
Score = 129 bits (325), Expect = 4e-30
Identities = 76/155 (49%), Positives = 105/155 (67%), Gaps = 7/155 (4%)
Query: 250 DVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSL-SQSTICRFESLTLS 308
D+ A ++LE FA+ KQ+RI LG TQADVG L L G + SQ+TICRFE+L LS
Sbjct: 138 DIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVL----FGKVFSQTTICRFEALQLS 193
Query: 309 HNNMIALKPILQAWLEEAEKSHR-EKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQ 367
NM L+P+LQ W+EEA+ + +++ K E A +KRKRTSI + +LE F
Sbjct: 194 FKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQA-RKRKRTSIENRVRGNLENLFLQC 252
Query: 368 PRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKR 402
P+P+ ++I+ IA++L L+K+VVRVWFCN+RQK KR
Sbjct: 253 PKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKR 287
>gi|227430410 POU class 5 homeobox 1B [Homo sapiens]
Length = 359
Score = 124 bits (311), Expect = 2e-28
Identities = 76/155 (49%), Positives = 103/155 (66%), Gaps = 8/155 (5%)
Query: 250 DVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSL-SQSTICRFESLTLS 308
D+ A ++LE FA+ KQ+RI LG TQADVG L L G + SQ TICRFE+L LS
Sbjct: 138 DIKALQKELEQFAKLLKQKRITLGYTQADVGLILGVL----FGKVFSQKTICRFEALQLS 193
Query: 309 HNNMIALKPILQAWLEEAEKSHR-EKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQ 367
NM L+P+LQ W+EEA+ + +++ K E A +KRKRTSI + +LE F
Sbjct: 194 FKNMCKLRPLLQKWVEEADNNENLQEICKAETLMQA-RKRKRTSIENRVRGNLENLFLQC 252
Query: 368 PRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKR 402
P+P+ + I+ IA++L L+K+VVRVWFCN+RQK KR
Sbjct: 253 PKPTLQ-ISHIAQQLGLEKDVVRVWFCNRRQKGKR 286
>gi|223890225 POU class 6 homeobox 1 [Homo sapiens]
Length = 301
Score = 113 bits (283), Expect = 3e-25
Identities = 70/195 (35%), Positives = 104/195 (53%), Gaps = 8/195 (4%)
Query: 212 VVSTPAHAPHMATMNPMHQAALSMAHAHGLPS--HMGCMSDVDADPRDLEAFAERFKQRR 269
V+++PA A + P+ L S H + + + ++ FA+ FK RR
Sbjct: 99 VIASPAPAAKPSASAPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRR 158
Query: 270 IKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKS 329
+ LG+TQ VG AL + P + SQS ICRFE L ++ + LKP+L+ WL EAE
Sbjct: 159 LSLGLTQTQVGQALTATEGP---AYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELR 215
Query: 330 HREKLTKPELFNGAE---KKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKK 386
++E F G E K+++RTS +L AYF P P+ ++I IA++L+ +
Sbjct: 216 NQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDR 275
Query: 387 NVVRVWFCNQRQKQK 401
VVRVWFCN+RQ K
Sbjct: 276 EVVRVWFCNRRQTLK 290
>gi|23463326 POU domain class 5, transcription factor 2 [Homo
sapiens]
Length = 328
Score = 99.8 bits (247), Expect = 4e-21
Identities = 61/155 (39%), Positives = 91/155 (58%), Gaps = 7/155 (4%)
Query: 250 DVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANL--KIPGVGSLSQSTICRFESLTL 307
D+ ++L+ A+ +Q+R+ LG +QADVG A+ L K+ LSQ+TICRFE+ L
Sbjct: 118 DISGILKELQQLAKELRQKRLSLGYSQADVGIAVGALFGKV-----LSQTTICRFEAQQL 172
Query: 308 SHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQ 367
S NM L+P+L+ WL+E E + L K E+ K +R S SLE +F
Sbjct: 173 SVANMWKLRPLLKKWLKEVEAENLLGLCKMEMILQQSGKWRRASRERRIGNSLEKFFQRC 232
Query: 368 PRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKR 402
P+P+ ++I+ IA L L+K+VVRVWF N+ + R
Sbjct: 233 PKPTPQQISHIAGCLQLQKDVVRVWFYNRSKMGSR 267
>gi|157743257 POU domain, class 6, transcription factor 2 [Homo
sapiens]
Length = 691
Score = 98.2 bits (243), Expect = 1e-20
Identities = 77/260 (29%), Positives = 116/260 (44%), Gaps = 49/260 (18%)
Query: 182 HQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHGL 241
HQP Q G+ S G L +A ++ +P ++ + +ALS+
Sbjct: 413 HQPSQTSVGQAA---SQGNLLH-LAHSQASMSQSPVRQASSSSSSSSSSSALSVGQLVSN 468
Query: 242 PSHMGCMSDVDA-DPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTIC 300
P +VD + ++ FA+ FK RR+ LG+TQ VG AL+ + P + SQS IC
Sbjct: 469 PQTAA--GEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGP---AYSQSAIC 523
Query: 301 R------------------------------------FESLTLSHNNMIALKPILQAWLE 324
R FE L ++ + +KP+L+ W+
Sbjct: 524 RHTILRSHFFLPQEAQENTIASSLTAKLNPGLLYPARFEKLDITPKSAQKIKPVLERWMA 583
Query: 325 EAEKSHREKLTKPELFNGAE---KKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEK 381
EAE HR + F G+E K+++RTS L A+F PS +++ IAEK
Sbjct: 584 EAEARHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEK 643
Query: 382 LDLKKNVVRVWFCNQRQKQK 401
L+ + VVRVWFCN+RQ K
Sbjct: 644 LNYDREVVRVWFCNKRQALK 663
>gi|119220564 one cut domain, family member 2 [Homo sapiens]
Length = 504
Score = 82.0 bits (201), Expect = 9e-16
Identities = 113/454 (24%), Positives = 160/454 (35%), Gaps = 109/454 (24%)
Query: 47 PSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDES 106
P+ + GGGGGGGGGGGGG G +S S G A P PP L +
Sbjct: 35 PAGGGSGGGGGGGGGGGGGGPGHEQELLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTA 94
Query: 107 LLARAEALAAVDIVSQS--------KSHHHHPPHH--------SP--FKPDATYHTMNTI 148
A A A + + S + + P HH SP TY T+ +
Sbjct: 95 AAAAAAASRSAMVTSMASILDGGDYRPELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPL 154
Query: 149 PCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQ------------------------- 183
S+ S HP HHH HHHHHHHHQ
Sbjct: 155 QPLPPISTVSDKFHHPH----PHHHPHHHHHHHHQRLSGNVSGSFTLMRDERGLPAMNNL 210
Query: 184 --PHQALEGELLEHLSP------GLALGAM---------AGPDG----AVVSTPAHAPHM 222
P++ + G + + LSP G LG + GP G + AH M
Sbjct: 211 YSPYKEMPG-MSQSLSPLAATPLGNGLGGLHNAQQSLPNYGPPGHDKMLSPNFDAHHTAM 269
Query: 223 ATMNPMHQA-------ALSMAHAHGL--PSHMGCMSDVDADPRDLEAFAERFKQ------ 267
T H + A M+H +GL P H V A R+ + Q
Sbjct: 270 LTRGEQHLSRGLGTPPAAMMSHLNGLHHPGHTQSHGPVLAPSRERPPSSSSGSQVATSGQ 329
Query: 268 -RRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKP--------- 317
I + + L IP +Q +CR + TLS + + KP
Sbjct: 330 LEEINTKEVAQRITAELKRYSIP-QAIFAQRVLCRSQG-TLS-DLLRNPKPWSKLKSGRE 386
Query: 318 ---ILQAWLEEAE---------KSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFA 365
+ WL+E E + + K +P +K+ R ++R+L A F
Sbjct: 387 TFRRMWKWLQEPEFQRMSALRLAACKRKEQEPNKDRNNSQKKSRLVFTDLQRRTLFAIFK 446
Query: 366 IQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQK 399
RPS E I+++L L+ V +F N R++
Sbjct: 447 ENKRPSKEMQITISQQLGLELTTVSNFFMNARRR 480
>gi|71274111 v-maf musculoaponeurotic fibrosarcoma oncogene homolog
A [Homo sapiens]
Length = 353
Score = 75.1 bits (183), Expect = 1e-13
Identities = 52/170 (30%), Positives = 60/170 (35%), Gaps = 9/170 (5%)
Query: 30 HSTSPGS------SAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGG 83
H PGS S P + SSPS + + G GGGGG GGGGG + + SGG G
Sbjct: 43 HRLPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGGGGGAGGGGGSSQAGGAPGPPSGGPG 102
Query: 84 SEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDAT-- 141
+ G L A L D V HH HH P A
Sbjct: 103 AVGGTSGKPALEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHGAHHGAHHPAAAAA 162
Query: 142 YHTMNTIPCTSAASSSSVPISHP-SALAGTHHHHHHHHHHHHQPHQALEG 190
Y + + H A HHHH HHHHHH H G
Sbjct: 163 YEAFRGPGFAGGGGADDMGAGHHHGAHHAAHHHHAAHHHHHHHHHHGGAG 212
>gi|84105335 mesenchyme homeobox 2 [Homo sapiens]
Length = 304
Score = 62.4 bits (150), Expect = 7e-10
Identities = 65/266 (24%), Positives = 98/266 (36%), Gaps = 68/266 (25%)
Query: 149 PCTSAASSSSVPISHPSALA--------GTHHHHHHHHHHHH--QPHQALEGELLEHLSP 198
P S +SSS + +P+ G HHHHHHHHHHHH Q HQAL+
Sbjct: 39 PELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHHQQQQHQALQ--------- 89
Query: 199 GLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDL 258
T H P M++ + +L + G P +G V
Sbjct: 90 ----------------TNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPV------- 126
Query: 259 EAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPI 318
L + +GS+ G + + E+ S
Sbjct: 127 -------------LCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAEKRSGGKR------ 167
Query: 319 LQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAI 378
+ +E K E+ ++ +++RT+ + R LEA FA + + I
Sbjct: 168 -----KSDSSDSQEGNYKSEV--NSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEI 220
Query: 379 AEKLDLKKNVVRVWFCNQRQKQKRMK 404
A LDL + V+VWF N+R K KR+K
Sbjct: 221 AVNLDLTERQVKVWFQNRRMKWKRVK 246
>gi|20070107 orthodenticle homeobox 1 [Homo sapiens]
Length = 354
Score = 61.6 bits (148), Expect = 1e-09
Identities = 52/180 (28%), Positives = 68/180 (37%), Gaps = 34/180 (18%)
Query: 31 STSPGSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRA 90
S SPGS AP + S P ++ + G +S S G G G
Sbjct: 181 SISPGS-APASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQG----- 234
Query: 91 CLPTPPSNIFGGLD-ESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIP 149
PTP S+ FGG+D S LA + HHHP SP P + + P
Sbjct: 235 -YPTPSSSYFGGVDCSSYLAPMHS-------------HHHPHQLSPMAPSSMAGHHHHHP 280
Query: 150 CTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQAL---EGELLEHLSPGLALGAMA 206
HP + + HHHHHHHHHH L + L++ PG A + A
Sbjct: 281 HAH----------HPLSQSSGHHHHHHHHHHQGYGGSGLAFNSADCLDYKEPGAAAASSA 330
Score = 36.2 bits (82), Expect = 0.055
Identities = 20/63 (31%), Positives = 36/63 (57%)
Query: 344 EKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRM 403
+++R+RT+ + LEA FA P +A K++L ++ V+VWF N+R K ++
Sbjct: 37 KQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQ 96
Query: 404 KYS 406
+ S
Sbjct: 97 QQS 99
>gi|6912752 zinc finger protein 281 [Homo sapiens]
Length = 895
Score = 60.5 bits (145), Expect = 3e-09
Identities = 57/206 (27%), Positives = 66/206 (32%), Gaps = 25/206 (12%)
Query: 59 GGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDE----SLLARAEAL 114
GGGG G GG S SG GGGGS R PT P + + R
Sbjct: 10 GGGGTGSSGGSGSGGGGSGGGGGGGSSGRRAEMEPTFPQGMVMFNHRLPPVTSFTRPAGS 69
Query: 115 AAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAAS-----------SSSVPISH 163
AA S P P P A T P SAA+ S V I
Sbjct: 70 AAPPPQCVLSSSTSAAPAAEPPPPPAPDMTFKKEPAASAAAFPSQRTSWGFLQSLVSIKQ 129
Query: 164 PSALAGTHHHHHHHHHHHHQPHQALEGELL---EHLSPGLALGAMAGPDGAVVSTPAHAP 220
HHHHHHHH G L E SPGL G G G +
Sbjct: 130 EKPADPEEQQSHHHHHHHHY------GGLFAGAEERSPGLG-GGEGGSHGVIQDLSILHQ 182
Query: 221 HMATMNPMHQAALSMAHAHGLPSHMG 246
H+ H + ++ + H G
Sbjct: 183 HVQQQPAQHHRDVLLSSSSRTDDHHG 208
>gi|239757043 PREDICTED: functional smad suppressing element 18
[Homo sapiens]
Length = 996
Score = 59.3 bits (142), Expect = 6e-09
Identities = 59/214 (27%), Positives = 74/214 (34%), Gaps = 30/214 (14%)
Query: 35 GSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPT 94
GS+ P P +N G G GG G + S G SGG S T
Sbjct: 521 GSAEAAPPPGQPPQVVANGPGSGPPPPAGGAGSRDALFESPPGGSGGDCSAGS------T 574
Query: 95 PPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPH--------------HSPFKPDA 140
PP+ D A A A AA + S+ H PH S F+P
Sbjct: 575 PPA------DSVAAAGAGAAAAGSGPAGSRVPAPHHPHLLEGRKAGGGSYHHSSAFRPVG 628
Query: 141 TYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGL 200
++ AS+ + H + HHHH HHHHHHH P Q LL P
Sbjct: 629 GKDDAESLAKLHGASAGA---PHSAQTHPHHHHHPHHHHHHHHPPQPPSPLLLLPPQPDE 685
Query: 201 ALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALS 234
P P P +A +P H+ LS
Sbjct: 686 PGSERHHPAPPPPPPPPPPPPLA-QHPHHRGLLS 718
Score = 51.6 bits (122), Expect = 1e-06
Identities = 46/168 (27%), Positives = 53/168 (31%), Gaps = 54/168 (32%)
Query: 28 ALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSS-----SGSSGGG 82
AL + PG S + S+P + S A G G G G G + G GG
Sbjct: 556 ALFESPPGGSGGDCSAGSTPPADSVAAAGAGAAAAGSGPAGSRVPAPHHPHLLEGRKAGG 615
Query: 83 GSEAMRRACLPTPPSNIFGGLD--ESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDA 140
GS A P GG D ESL A A +Q+ HHHH PH
Sbjct: 616 GSYHHSSAFRPV------GGKDDAESLAKLHGASAGAPHSAQTHPHHHHHPH-------- 661
Query: 141 TYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQAL 188
HHHHHHH QP L
Sbjct: 662 ---------------------------------HHHHHHHPPQPPSPL 676
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 6/89 (6%)
Query: 21 HVEPKYS----ALHSTSPGSSAPIAPSASSPSSSSNAGGGG--GGGGGGGGGGGRSSSSS 74
H P++ +L + ++A ++ +A+S S ++ +GG G GGG GGG G +
Sbjct: 306 HKRPRFDDDDDSLQEAAVVAAASLSAAAASLSVAAASGGAGTGGGGAGGGCVAGVGVGAG 365
Query: 75 SSGSSGGGGSEAMRRACLPTPPSNIFGGL 103
+ +G G +P P FGG+
Sbjct: 366 AGAGAGAGAKGPRSYPVIPVPSKGSFGGV 394
>gi|239751555 PREDICTED: functional smad suppressing element 18
[Homo sapiens]
Length = 1252
Score = 59.3 bits (142), Expect = 6e-09
Identities = 59/214 (27%), Positives = 74/214 (34%), Gaps = 30/214 (14%)
Query: 35 GSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPT 94
GS+ P P +N G G GG G + S G SGG S T
Sbjct: 521 GSAEAAPPPGQPPQVVANGPGSGPPPPAGGAGSRDALFESPPGGSGGDCSAGS------T 574
Query: 95 PPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPH--------------HSPFKPDA 140
PP+ D A A A AA + S+ H PH S F+P
Sbjct: 575 PPA------DSVAAAGAGAAAAGSGPAGSRVPAPHHPHLLEGRKAGGGSYHHSSAFRPVG 628
Query: 141 TYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGL 200
++ AS+ + H + HHHH HHHHHHH P Q LL P
Sbjct: 629 GKDDAESLAKLHGASAGA---PHSAQTHPHHHHHPHHHHHHHHPPQPPSPLLLLPPQPDE 685
Query: 201 ALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALS 234
P P P +A +P H+ LS
Sbjct: 686 PGSERHHPAPPPPPPPPPPPPLA-QHPHHRGLLS 718
Score = 51.6 bits (122), Expect = 1e-06
Identities = 46/168 (27%), Positives = 53/168 (31%), Gaps = 54/168 (32%)
Query: 28 ALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSS-----SGSSGGG 82
AL + PG S + S+P + S A G G G G G + G GG
Sbjct: 556 ALFESPPGGSGGDCSAGSTPPADSVAAAGAGAAAAGSGPAGSRVPAPHHPHLLEGRKAGG 615
Query: 83 GSEAMRRACLPTPPSNIFGGLD--ESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDA 140
GS A P GG D ESL A A +Q+ HHHH PH
Sbjct: 616 GSYHHSSAFRPV------GGKDDAESLAKLHGASAGAPHSAQTHPHHHHHPH-------- 661
Query: 141 TYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQAL 188
HHHHHHH QP L
Sbjct: 662 ---------------------------------HHHHHHHPPQPPSPL 676
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 6/89 (6%)
Query: 21 HVEPKYS----ALHSTSPGSSAPIAPSASSPSSSSNAGGGG--GGGGGGGGGGGRSSSSS 74
H P++ +L + ++A ++ +A+S S ++ +GG G GGG GGG G +
Sbjct: 306 HKRPRFDDDDDSLQEAAVVAAASLSAAAASLSVAAASGGAGTGGGGAGGGCVAGVGVGAG 365
Query: 75 SSGSSGGGGSEAMRRACLPTPPSNIFGGL 103
+ +G G +P P FGG+
Sbjct: 366 AGAGAGAGAKGPRSYPVIPVPSKGSFGGV 394
>gi|239746067 PREDICTED: functional smad suppressing element 18
[Homo sapiens]
Length = 1252
Score = 59.3 bits (142), Expect = 6e-09
Identities = 59/214 (27%), Positives = 74/214 (34%), Gaps = 30/214 (14%)
Query: 35 GSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPT 94
GS+ P P +N G G GG G + S G SGG S T
Sbjct: 521 GSAEAAPPPGQPPQVVANGPGSGPPPPAGGAGSRDALFESPPGGSGGDCSAGS------T 574
Query: 95 PPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPH--------------HSPFKPDA 140
PP+ D A A A AA + S+ H PH S F+P
Sbjct: 575 PPA------DSVAAAGAGAAAAGSGPAGSRVPAPHHPHLLEGRKAGGGSYHHSSAFRPVG 628
Query: 141 TYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGL 200
++ AS+ + H + HHHH HHHHHHH P Q LL P
Sbjct: 629 GKDDAESLAKLHGASAGA---PHSAQTHPHHHHHPHHHHHHHHPPQPPSPLLLLPPQPDE 685
Query: 201 ALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALS 234
P P P +A +P H+ LS
Sbjct: 686 PGSERHHPAPPPPPPPPPPPPLA-QHPHHRGLLS 718
Score = 51.6 bits (122), Expect = 1e-06
Identities = 46/168 (27%), Positives = 53/168 (31%), Gaps = 54/168 (32%)
Query: 28 ALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSS-----SGSSGGG 82
AL + PG S + S+P + S A G G G G G + G GG
Sbjct: 556 ALFESPPGGSGGDCSAGSTPPADSVAAAGAGAAAAGSGPAGSRVPAPHHPHLLEGRKAGG 615
Query: 83 GSEAMRRACLPTPPSNIFGGLD--ESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDA 140
GS A P GG D ESL A A +Q+ HHHH PH
Sbjct: 616 GSYHHSSAFRPV------GGKDDAESLAKLHGASAGAPHSAQTHPHHHHHPH-------- 661
Query: 141 TYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQAL 188
HHHHHHH QP L
Sbjct: 662 ---------------------------------HHHHHHHPPQPPSPL 676
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 6/89 (6%)
Query: 21 HVEPKYS----ALHSTSPGSSAPIAPSASSPSSSSNAGGGG--GGGGGGGGGGGRSSSSS 74
H P++ +L + ++A ++ +A+S S ++ +GG G GGG GGG G +
Sbjct: 306 HKRPRFDDDDDSLQEAAVVAAASLSAAAASLSVAAASGGAGTGGGGAGGGCVAGVGVGAG 365
Query: 75 SSGSSGGGGSEAMRRACLPTPPSNIFGGL 103
+ +G G +P P FGG+
Sbjct: 366 AGAGAGAGAKGPRSYPVIPVPSKGSFGGV 394
>gi|4507163 SRY (sex determining region Y)-box 4 [Homo sapiens]
Length = 474
Score = 58.5 bits (140), Expect = 1e-08
Identities = 45/156 (28%), Positives = 68/156 (43%), Gaps = 17/156 (10%)
Query: 31 STSPGSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSE---AM 87
S + SS+ A S+ GG GGGG GGGGGGG S++ G + GGG+ A
Sbjct: 136 SGNANSSSSAAASSKPGEKGDKVGGSGGGGHGGGGGGGSSNAGGGGGGASGGGANSKPAQ 195
Query: 88 RRACLPTPPSNIFGGLDES----LLA------RAEALAAVDIVSQSKSHHHHPPHHSPFK 137
+++C GG+ + +LA +A A AA ++ P
Sbjct: 196 KKSCGSKVAGGAGGGVSKPHAKLILAGGGGGGKAAAAAAASFAAEQAG----AAALLPLG 251
Query: 138 PDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHH 173
A +H++ SA++S+S S +ALA H
Sbjct: 252 AAADHHSLYKARTPSASASASSAASASAALAAPGKH 287
Score = 30.8 bits (68), Expect = 2.3
Identities = 39/135 (28%), Positives = 55/135 (40%), Gaps = 24/135 (17%)
Query: 4 MSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGGGGG 63
+S S A S G S Y++L + SP S+ APS +S S+SS+
Sbjct: 339 LSGRSSAASSPAAGRSPADHRGYASLRAASPAPSS--APSHASSSASSH----------- 385
Query: 64 GGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEAL---AAVDIV 120
SSSSSSSGSS + L PS+ F + + + AL +
Sbjct: 386 ------SSSSSSSGSS--SSDDEFEDDLLDLNPSSNFESMSLGSFSSSSALDRDLDFNFE 437
Query: 121 SQSKSHHHHPPHHSP 135
S SH P + +P
Sbjct: 438 PGSGSHFEFPDYCTP 452
>gi|238859557 regulatory factor X1 [Homo sapiens]
Length = 979
Score = 57.4 bits (137), Expect = 2e-08
Identities = 28/50 (56%), Positives = 34/50 (68%), Gaps = 2/50 (4%)
Query: 37 SAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEA 86
S +A S S+ + +SN+ GGGG GGGGGGGGG SGS+GGGGS A
Sbjct: 363 SQVVASSTSTGAGASNSSGGGGSGGGGGGGGG--GGGGGSGSTGGGGSGA 410
Score = 55.5 bits (132), Expect = 9e-08
Identities = 31/75 (41%), Positives = 38/75 (50%), Gaps = 9/75 (12%)
Query: 8 SKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGG 67
+ QA + ++V STS G+ A S+SS GG GGGGGGGGGGG
Sbjct: 346 TSQAVASSGSMPMYVSGSQVVASSTSTGAGA---------SNSSGGGGSGGGGGGGGGGG 396
Query: 68 GRSSSSSSSGSSGGG 82
G S S+ G SG G
Sbjct: 397 GGGSGSTGGGGSGAG 411
>gi|4826734 fusion (involved in t(12;16) in malignant liposarcoma)
[Homo sapiens]
Length = 526
Score = 57.0 bits (136), Expect = 3e-08
Identities = 27/79 (34%), Positives = 36/79 (45%)
Query: 5 SLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGGGGGG 64
S + ++ P GS +P Y + + P + N+ GGGGGGGGG
Sbjct: 115 SSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGG 174
Query: 65 GGGGRSSSSSSSGSSGGGG 83
G G+ SS SSG GGG
Sbjct: 175 GNYGQDQSSMSSGGGSGGG 193
Score = 43.1 bits (100), Expect = 5e-04
Identities = 29/89 (32%), Positives = 36/89 (40%), Gaps = 10/89 (11%)
Query: 5 SLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGG----GG 60
S +Q+++ P G + S+ G SS SS +GGG G G
Sbjct: 142 SYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSG 201
Query: 61 GGGGGG------GGRSSSSSSSGSSGGGG 83
GGG GG GGR S G GGGG
Sbjct: 202 GGGSGGYGQQDRGGRGRGGSGGGGGGGGG 230
Score = 40.8 bits (94), Expect = 0.002
Identities = 19/35 (54%), Positives = 20/35 (57%)
Query: 54 GGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMR 88
G GG GGGGGGGGGG + SS G GG R
Sbjct: 217 GRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGR 251
Score = 39.7 bits (91), Expect = 0.005
Identities = 27/74 (36%), Positives = 31/74 (41%), Gaps = 16/74 (21%)
Query: 36 SSAPIAPSASSPSSSSNAGGG--------------GGGGGGGGGGGGRSSSSSSSGSSGG 81
S PI S ++ + N GGG GG GGGG GGGGR SG GG
Sbjct: 360 SGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGR--GGFPSGGGGG 417
Query: 82 GGSEAMRRACLPTP 95
GG + P P
Sbjct: 418 GGQQRAGDWKCPNP 431
Score = 34.7 bits (78), Expect = 0.16
Identities = 20/41 (48%), Positives = 20/41 (48%), Gaps = 9/41 (21%)
Query: 51 SNAGGGGGGGG-----GG----GGGGGRSSSSSSSGSSGGG 82
S GGGGGGGG GG G GGGR GS GG
Sbjct: 221 SGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGG 261
Score = 30.0 bits (66), Expect = 4.0
Identities = 18/47 (38%), Positives = 19/47 (40%), Gaps = 13/47 (27%)
Query: 50 SSNAGGGGGGG-------------GGGGGGGGRSSSSSSSGSSGGGG 83
S GGGGGGG GGG GG G S G + GG
Sbjct: 221 SGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGG 267
>gi|33620755 YEATS domain containing 2 [Homo sapiens]
Length = 1422
Score = 57.0 bits (136), Expect = 3e-08
Identities = 33/86 (38%), Positives = 48/86 (55%), Gaps = 9/86 (10%)
Query: 2 MMMSLNSKQAFSMPHG-GSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGG 60
+ ++ NSK P G G L + P+ + L +T+ + S S+ S S AGGGGGGG
Sbjct: 759 LYLTTNSKN----PSGKGKLLLIPQGAILRATNNAN----LQSGSAASGGSGAGGGGGGG 810
Query: 61 GGGGGGGGRSSSSSSSGSSGGGGSEA 86
GGGG G G S+ G + GGG+++
Sbjct: 811 GGGGSGSGGGGSTGGGGGTAGGGTQS 836
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.127 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,698,640
Number of Sequences: 37866
Number of extensions: 953967
Number of successful extensions: 37345
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1045
Number of HSP's successfully gapped in prelim test: 340
Number of HSP's that attempted gapping in prelim test: 11896
Number of HSP's gapped (non-prelim): 11185
length of query: 409
length of database: 18,247,518
effective HSP length: 105
effective length of query: 304
effective length of database: 14,271,588
effective search space: 4338562752
effective search space used: 4338562752
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.