Search of human proteins with 154800457

Search of human proteins with 154800457

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|154800457 centrosomal protein 68kDa [Homo sapiens]
         (757 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|154800457 centrosomal protein 68kDa [Homo sapiens]                1535   0.0  
gi|21493045 A-kinase anchor protein 6 [Homo sapiens]                   74   5e-13
gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapi...    54   7e-07
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    51   3e-06
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    49   2e-05
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...    47   5e-05
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    47   5e-05
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    44   4e-04
gi|163965366 nascent polypeptide-associated complex alpha subuni...    44   6e-04
gi|33946327 nucleoporin 214kDa [Homo sapiens]                          44   7e-04
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        42   0.003
gi|45439357 elongin A2 [Homo sapiens]                                  41   0.004
gi|237757310 synaptojanin 1 isoform a [Homo sapiens]                   40   0.006
gi|92859678 small nuclear RNA activating complex, polypeptide 4,...    40   0.008
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    40   0.010
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof...    39   0.014
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo...    39   0.014
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof...    39   0.014
gi|55769533 PRKC, apoptosis, WT1, regulator [Homo sapiens]             39   0.018
gi|46409266 coiled-coil domain containing 74B [Homo sapiens]           39   0.023
gi|239740972 PREDICTED: hypothetical protein [Homo sapiens]            38   0.030
gi|58530876 melanoma antigen family C, 1 [Homo sapiens]                38   0.030
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]    38   0.030
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              38   0.030
gi|14249150 single stranded DNA binding protein 4 isoform a [Hom...    38   0.040
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]              37   0.052
gi|237757312 synaptojanin 1 isoform c [Homo sapiens]                   37   0.068
gi|60097902 filaggrin [Homo sapiens]                                   37   0.068
gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens]      37   0.068
gi|149158690 HLA-B associated transcript-2 [Homo sapiens]              37   0.068

>gi|154800457 centrosomal protein 68kDa [Homo sapiens]
          Length = 757

 Score = 1535 bits (3973), Expect = 0.0
 Identities = 757/757 (100%), Positives = 757/757 (100%)

Query: 1   MALGEEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPRLEAEGGLISPVWGAEG 60
           MALGEEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPRLEAEGGLISPVWGAEG
Sbjct: 1   MALGEEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPRLEAEGGLISPVWGAEG 60

Query: 61  IPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQV 120
           IPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQV
Sbjct: 61  IPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQV 120

Query: 121 EKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLSCLSQ 180
           EKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLSCLSQ
Sbjct: 121 EKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLSCLSQ 180

Query: 181 WKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSVV 240
           WKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSVV
Sbjct: 181 WKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSVV 240

Query: 241 GLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYE 300
           GLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYE
Sbjct: 241 GLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYE 300

Query: 301 DLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPA 360
           DLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPA
Sbjct: 301 DLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPA 360

Query: 361 EATALPFSGPREPSLKQWPSRVPQKQGGMGLASWSQLASTPRAPGSRDARWERREPALRG 420
           EATALPFSGPREPSLKQWPSRVPQKQGGMGLASWSQLASTPRAPGSRDARWERREPALRG
Sbjct: 361 EATALPFSGPREPSLKQWPSRVPQKQGGMGLASWSQLASTPRAPGSRDARWERREPALRG 420

Query: 421 AKDRLTIGKHLDMGSPQLRTRDRGWPSPRPEREKRTSQSARRPTCTESRWKSEEEVESDD 480
           AKDRLTIGKHLDMGSPQLRTRDRGWPSPRPEREKRTSQSARRPTCTESRWKSEEEVESDD
Sbjct: 421 AKDRLTIGKHLDMGSPQLRTRDRGWPSPRPEREKRTSQSARRPTCTESRWKSEEEVESDD 480

Query: 481 EYLALPARLTQVSSLVSYLGSISTLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLP 540
           EYLALPARLTQVSSLVSYLGSISTLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLP
Sbjct: 481 EYLALPARLTQVSSLVSYLGSISTLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLP 540

Query: 541 PGAALQGSGDPEGQNPCFLRSFVRAHDSAGEGSLGSSQALGVSSGLLKTRPSLPARLDRW 600
           PGAALQGSGDPEGQNPCFLRSFVRAHDSAGEGSLGSSQALGVSSGLLKTRPSLPARLDRW
Sbjct: 541 PGAALQGSGDPEGQNPCFLRSFVRAHDSAGEGSLGSSQALGVSSGLLKTRPSLPARLDRW 600

Query: 601 PFSDPDVEGQLPRKGGEQGKESLVQCVKTFCCQLEELICWLYNVADVTDHGTAARSNLTS 660
           PFSDPDVEGQLPRKGGEQGKESLVQCVKTFCCQLEELICWLYNVADVTDHGTAARSNLTS
Sbjct: 601 PFSDPDVEGQLPRKGGEQGKESLVQCVKTFCCQLEELICWLYNVADVTDHGTAARSNLTS 660

Query: 661 LKSSLQLYRQFKKDIDEHQSLTESVLQKGEILLQCLLENTPVLEDVLGRIAKQSGELESH 720
           LKSSLQLYRQFKKDIDEHQSLTESVLQKGEILLQCLLENTPVLEDVLGRIAKQSGELESH
Sbjct: 661 LKSSLQLYRQFKKDIDEHQSLTESVLQKGEILLQCLLENTPVLEDVLGRIAKQSGELESH 720

Query: 721 ADRLYDSILASLDMLAGCTLIPDKKPMAAMEHPCEGV 757
           ADRLYDSILASLDMLAGCTLIPDKKPMAAMEHPCEGV
Sbjct: 721 ADRLYDSILASLDMLAGCTLIPDKKPMAAMEHPCEGV 757


>gi|21493045 A-kinase anchor protein 6 [Homo sapiens]
          Length = 2319

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 79/323 (24%), Positives = 136/323 (42%), Gaps = 44/323 (13%)

Query: 446 PSPRPEREKRTSQSARRPTCTESRWKSEEEVESDDEYLALPARLTQVSSLVSYLGSISTL 505
           P P   + K     A  P+      +  E     DEYLALP+ L Q   L   L +++ L
Sbjct: 594 PVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKL 653

Query: 506 VTL-PTGD-IKGQSPLEVSDSDGPASF-----------------PSSSSQSQLPPGAALQ 546
           +   P G+ I+     E+S+ +  +                   PSSSS      G +++
Sbjct: 654 LPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIE 713

Query: 547 GS------GDPEGQNPCFLRSFVRAHDSAGEGSLGSSQALGVSSGLLKTRPSLPARLDRW 600
                    D E   P  L    +  D   E +  S +    S+    T+ +L  +L + 
Sbjct: 714 SGPLSDILSDEESSMP--LAGMKKYADEKSERASSSEKNESHSA----TKSALIQKLMQ- 766

Query: 601 PFSDPDVEGQLPRKGGEQGKESLVQCVKTFCCQLEELICWLYNVADVTDHGTAARSNLTS 660
                D++ Q          E++ + ++ F  +L+E I WL    + T++ T  ++ +  
Sbjct: 767 -----DIQHQ-------DNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDD 814

Query: 661 LKSSLQLYRQFKKDIDEHQSLTESVLQKGEILLQCLLENTPVLEDVLGRIAKQSGELESH 720
           LK  L+ +  FK ++D H +L E+V ++G  LL+ +  +   L+D+L  IA Q  EL+  
Sbjct: 815 LKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQ 874

Query: 721 ADRLYDSILASLDMLAGCTLIPD 743
             R +  IL +LD +    L  D
Sbjct: 875 IKRQHSWILRALDTIKAEILATD 897


>gi|239752594 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 673

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 114/484 (23%), Positives = 164/484 (33%), Gaps = 67/484 (13%)

Query: 81  PQASDANREPVAERSEPALSGL----PPATMGSGDLLLSGESQVEKTKLSSSEEFPQTLS 136
           P+AS     P A  S    + L    PP    +G L     S+   TK+ S+    +T S
Sbjct: 225 PRASPTGSPPRASLSMMPSTALLIRTPPRASPTGML-----SRTSLTKMDSTASITRTPS 279

Query: 137 LPRTTTICSGHDADTEDDPSLADLPQALDLSQQ-PHSSGLSCLSQWKSVLSPGSAA---Q 192
            P T +        T    SL+  P    L +  P +S    LS+        +A+    
Sbjct: 280 RPSTAS-----PTGTPSRASLSMTPSTASLMRMLPRASPTGMLSRTSLTKMDSTASISRT 334

Query: 193 PSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSVVGLGPRPQWSPQP 252
           P   SI+ + + +S  G    A P G       S   P      +S+ GL      +  P
Sbjct: 335 PPRASITRTPSRASPTGKPSTASPTG-----TPSRASPTGSPSTASLTGLSS----TASP 385

Query: 253 VFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYEDLLDYTYPLRPG 312
             +   AS  G    +            SL   P R SP    ++     +D T      
Sbjct: 386 TGTPPRASPTGTPSTA------------SLTRKPPRASPTGMLSRTSITKMDSTASPTRT 433

Query: 313 PQLPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPAEATALPFSGPRE 372
           P       +   A P    S     + + S AS   SP+  SP   P+  TA P   P  
Sbjct: 434 PPRASPTGTPPRASPTGTPSRAS-PTGTQSTASPTGSPSTASPTGSPS--TASPTGSPSR 490

Query: 373 PSLKQWPSRVPQKQGGMGLASWSQLASTPRAPGSRDARWERREPALRGAKDRLTIGKHLD 432
            SL + PSR         L      AS  R P      W     +  G+         L 
Sbjct: 491 ASLTRTPSRA-------SLTKMESTASITRTPSRASPTWTPSTASPTGSPSTA-----LA 538

Query: 433 MGSPQ----LRTRDRGWPSPRPEREKRTSQSARRPTCTESRWKSEEEVESDDEYLALPAR 488
           MGSP      RT  R   +  P R   T+ S    T T S         S      +P+R
Sbjct: 539 MGSPSRAALTRTPSRASLTRTPSRASLTTPSRASLTRTPSTVLLTRMPPSASP-TGMPSR 597

Query: 489 LTQV----SSLVSYLGSISTLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLPPGAA 544
            +      S+L++ + S +++   P       SP E      P   P  +S +  PP A+
Sbjct: 598 TSPTGMPSSALLTKMDSTASITRTPPR----ASPTETPPRASPTGTPPRASPTGTPPRAS 653

Query: 545 LQGS 548
             G+
Sbjct: 654 PTGT 657



 Score = 37.0 bits (84), Expect = 0.068
 Identities = 110/526 (20%), Positives = 165/526 (31%), Gaps = 112/526 (21%)

Query: 73  GGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDL----LLSGESQVEKTKLSSS 128
           G PSRA     + +    +   S  +L+G PP     G      L+   S+   T++ SS
Sbjct: 24  GTPSRASLT-GTPSTASLMGTPSRASLTGTPPRASLKGTTSMASLMVSPSRASLTRMQSS 82

Query: 129 EEFPQTLSL-------PRTTTICSGHDADTEDDPSLADL---PQALDLSQQPHSSGLSCL 178
               +T S+       PR +   +   A     PS A L   P    L+  P  + LS  
Sbjct: 83  SLLTRTPSMASLKRMPPRASRTRTLPRASLMRRPSTASLTRSPSRASLTTTPSRASLSMT 142

Query: 179 SQWKSVLSPGSAAQ-------------PSSCSISASSTGSSLQGHQERAEPRG------- 218
               + L+  S A              PS+ S++ +   +S  G   R  P G       
Sbjct: 143 PSTAAALTMPSRASLTRTPPRASLTMTPSTASLTRTPPRASPTGMPSRTSPTGMPSTASL 202

Query: 219 ------GSLAKVSSSLEPVVPQEPSSVVGLGPRPQWSPQP-----VFSGGDASGLGRRRL 267
                  S+ +  S   P      +S  G  PR   S  P     + +   AS  G    
Sbjct: 203 TKMDSTASITRTLSRASPTGTPPRASPTGSPPRASLSMMPSTALLIRTPPRASPTGMLSR 262

Query: 268 SFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDSRVPADP 327
           +   +  +       P  P   SP   P++    +   T        L + L    P   
Sbjct: 263 TSLTKMDSTASITRTPSRPSTASPTGTPSRASLSMTPST------ASLMRMLPRASPTGM 316

Query: 328 VLQDSGVDLDS---FSVSP--ASTLKSPTNVSPNCPPAEATALPFSGPREPSLKQWPSRV 382
           + + S   +DS    S +P  AS  ++P+  SP   P+  TA P   P   S    P+  
Sbjct: 317 LSRTSLTKMDSTASISRTPPRASITRTPSRASPTGKPS--TASPTGTPSRAS----PTGS 370

Query: 383 PQKQGGMGLASWSQLASTPRAPGSRDARWERREPALRGAKDRLTIGKHLDMGSPQLRTRD 442
           P      GL+S +    TP           R  P                 G+P   +  
Sbjct: 371 PSTASLTGLSSTASPTGTP----------PRASPT----------------GTPSTASLT 404

Query: 443 RGWPSPRPEREKRTSQSARRPTCTESRWKSEEEVESDDEYLALPARLTQVSSLVSYLGSI 502
           R     +P R   T   +R          S             P R +            
Sbjct: 405 R-----KPPRASPTGMLSRTSITKMDSTASPTRTPPRASPTGTPPRAS------------ 447

Query: 503 STLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLPPGAALQGS 548
                 PTG     SP     +  P   PS++S +  P  A+  GS
Sbjct: 448 ------PTGTPSRASPTGTQSTASPTGSPSTASPTGSPSTASPTGS 487


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 113/443 (25%), Positives = 151/443 (34%), Gaps = 71/443 (16%)

Query: 4   GEEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPRLEAEGGLI------SPVWG 57
           GE    A+ +      S GR S   R    PGP+ G++  R+ AE  +       +P   
Sbjct: 100 GERAPPAKNTSPGPVSSPGRASGTTR----PGPL-GQKGLRISAEETVARGKATEAPKRS 154

Query: 58  AEGIPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGE 117
           A    A     G  PG PS A   ++  A  E    R  P+    PP T G    + S  
Sbjct: 155 ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPP-TEGPRKSVSSAS 213

Query: 118 SQVEKTKLSSSEEFPQT---LSLPRTTTICSGH---DADTEDDPSLADLPQALDLSQQPH 171
                    ++   P     L  P + ++ S      +     PS    P+A     QP 
Sbjct: 214 EHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPK 273

Query: 172 SSGLSCLSQWKSVLSPGSAAQP-----SSCSISASSTGSSLQGHQER---AEPRGGSLAK 223
             GL  L     V  P   A P     SS  ++  S  ++LQ        A P   SL  
Sbjct: 274 PKGLQALRP-PQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTC 332

Query: 224 VSSSLEPVVPQEPSSVVGLGPRPQWSPQPVFSGGDASGLGRRRL----SF---------- 269
             ++  P+ P  PS+   L   P  SP         + LG   L    SF          
Sbjct: 333 QLATPLPLAPPSPSAPPSLQTLP--SPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA 390

Query: 270 ----QAEYWACVLPDSLPPSPDRH---SPLWNPNKEYEDLLDYTY---PLRPGPQLPKHL 319
               QA     + P   PPSP      SPL  P+ +  + L       P  P P  P   
Sbjct: 391 TPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA 450

Query: 320 DSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPAEATALPFSGPREPSLKQWP 379
               PA P             VSP++T  S    S   PP +   +P S P  P +   P
Sbjct: 451 PFSPPASP------------PVSPSATPPSQAPPSLAAPPLQ---VPPSPPASPPMS--P 493

Query: 380 SRVPQKQGGMGLASWS-QLASTP 401
           S  P  Q    LA+   QLA  P
Sbjct: 494 SATPPPQAPPPLAAPPLQLAKPP 516



 Score = 30.4 bits (67), Expect = 6.4
 Identities = 66/217 (30%), Positives = 76/217 (35%), Gaps = 40/217 (18%)

Query: 193 PSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSVVGLGPRPQWSPQP 252
           P+S  +S S+T  S      +A P   SLA     + P  P  P       P PQ +P P
Sbjct: 455 PASPPVSPSATPPS------QAPP---SLAAPPLQVPPSPPASPPMSPSATPPPQ-APPP 504

Query: 253 VFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYEDLLDYTYPLR-P 311
           +     A  L   +   QA       P    PSP    P   P      L     PL  P
Sbjct: 505 LA----APPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLP--MSPLATP 558

Query: 312 GPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPAEATALPFSGPR 371
            PQ P  L     A P+LQ            P S   SPT  +P  PP        SGPR
Sbjct: 559 PPQAPPVL-----AAPLLQ-----------VPPSPPASPTLQAPRRPPTPGPDTSVSGPR 602

Query: 372 -----EPSLKQWPSRVPQKQ-GGMGLASWSQLA-STP 401
                 P     PSR P     G  LA  S  A STP
Sbjct: 603 LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTP 639


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
           sapiens]
          Length = 1560

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 87/381 (22%), Positives = 119/381 (31%), Gaps = 70/381 (18%)

Query: 73  GGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQVEKTKLSSSEEFP 132
           G P+    P +  A   P   +S+PA +G    T+  G  L      +  T        P
Sbjct: 550 GQPALFQMPVSLAAGSLPT--QSQPAPAGPAATTVLQGVTLPPSAVAMLNT--------P 599

Query: 133 QTLSLPRTTTICSGHDADTEDDPSLADLPQA----LDLSQQPHSSGLSCLSQWKSVLSPG 188
             L  P T    +G  A           P A    L L  Q   +     +      +P 
Sbjct: 600 DGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPP 659

Query: 189 SAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQE------------- 235
            A  P      ASS    + G    A P   +      SL+  +PQE             
Sbjct: 660 QATTPQPSPGLASSPEKIVLGQPPSATP---TAILTQDSLQMFLPQERSQQPLSAEGPHL 716

Query: 236 --PSSVVGLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLW 293
             P+SV+   P P   P P       +GLG +    QA       P   P  P   +PL 
Sbjct: 717 SVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQAS------PAPAPQIPAA-APLK 769

Query: 294 NPNKEYEDLLDYTYPLRPGPQLPKHLDSRVP--------------------------ADP 327
            P       L +  PL   P LP    +R P                          A P
Sbjct: 770 GPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPP 829

Query: 328 VLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPAEATALPFSGPREPSLKQWPSRVPQKQG 387
            L    V  +   V P ++  +PT   P  PP    + P  GP  P+       +P    
Sbjct: 830 TLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPA-----PHLPPSST 884

Query: 388 GMGLASWSQLASTPRAPGSRD 408
              +AS S+ +S   AP   D
Sbjct: 885 SSAVASSSETSSRLPAPTPSD 905


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
            potassium channel 4 [Homo sapiens]
          Length = 1203

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 77/305 (25%), Positives = 108/305 (35%), Gaps = 50/305 (16%)

Query: 97   PALSGLPPATMGSGDLLLSGESQVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPS 156
            PA    PP   G G+L   G  Q  +         P  L             A     PS
Sbjct: 802  PAAIFRPPPGSGLGNL---GAGQTPRHLKRLQSLIPSALG-----------SASPASSPS 847

Query: 157  LADLPQALDLSQQPHS-----SGLS-CLSQWKSVLSPGSAAQPSSCSISASSTGSSLQGH 210
              D P +     Q  +     +GLS  L    S   PG+   PS+ + SA    +++ G 
Sbjct: 848  QVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGF 907

Query: 211  QERAEPRGGSLAKVSSSLEPVVPQEPSSVVGLGPRPQWSPQPVFSGGDASGLGRRRLSFQ 270
                +  GGSL+   S L  + P +P +      +P  SP P    G   GLG       
Sbjct: 908  GHFHKALGGSLSSSDSPL--LTPLQPGARSPQAAQP--SPAP---PGARGGLG------- 953

Query: 271  AEYWACVLPDS-LPPSPDRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDSRVPADPVL 329
                   LP+  LPP P   SP  +P +  +   + +  L  GP        R P  P L
Sbjct: 954  -------LPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSL 1006

Query: 330  ---QDSGVDLDSFS----VSPASTLKSPTNVSPNCPPAEATALPFSGPREPSLKQWPSRV 382
                  G     F+    +SP      P    P+ PP  A+    S    P+    P +V
Sbjct: 1007 VAGASGGASPVGFTPRGGLSPPGHSPGPPRTFPSAPP-RASGSHGSLLLPPASSPPPPQV 1065

Query: 383  PQKQG 387
            PQ++G
Sbjct: 1066 PQRRG 1070



 Score = 33.5 bits (75), Expect = 0.75
 Identities = 32/135 (23%), Positives = 51/135 (37%), Gaps = 9/135 (6%)

Query: 315 LPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPAEATALPFS--GPRE 372
           +P  L S  PA    Q       SF +   +   +P  +SP  P + ++  P +   P  
Sbjct: 833 IPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSA 892

Query: 373 PSLKQWPSRVP-------QKQGGMGLASWSQLASTPRAPGSRDARWERREPALRGAKDRL 425
           P+     +           K  G  L+S      TP  PG+R  +  +  PA  GA+  L
Sbjct: 893 PTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGL 952

Query: 426 TIGKHLDMGSPQLRT 440
            + +H     P  R+
Sbjct: 953 GLPEHFLPPPPSSRS 967


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 136/559 (24%), Positives = 182/559 (32%), Gaps = 145/559 (25%)

Query: 4   GEEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPRLEAEGGLI------SPVWG 57
           GE    A+ +      S GR S   R    PGP+ G++  R+ AE  +       +P   
Sbjct: 100 GERAPPAKNTSPGPVSSPGRASGTTR----PGPL-GQKGLRISAEETVARGKATEAPKRS 154

Query: 58  AEGIPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGE 117
           A    A     G  PG PS A   ++  A  E    R  P+    PP T G         
Sbjct: 155 ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPP-TEG--------- 204

Query: 118 SQVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLSC 177
                               PR +   +   + TE  P+    P A    Q+P S  LS 
Sbjct: 205 --------------------PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS- 243

Query: 178 LSQWKSVLSPGSAAQPSSCSISASSTGSSLQG------HQERAEPRGGSLAKVSSSLEP- 230
                      S+A P S   S + +G S +G      H  + +P+G        +L P 
Sbjct: 244 -----------SSATPLS---SPARSGPSARGTPRAPAHPSQPKPKG------LQALRPP 283

Query: 231 -VVPQEPSSVVGLGP---RPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSP 286
            V P    +   LGP    P  +P P       SG   R +    +  A  LP +LPPSP
Sbjct: 284 QVTPPRKDAAPALGPLSSSPLATPSP-------SGTKARPVP-PPDNAATPLPATLPPSP 335

Query: 287 DRHSPLWNPNKEYEDLLDYTYPLR-PGPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPAS 345
              +PL               PL  P P  P          P LQ               
Sbjct: 336 PLATPL---------------PLAPPSPSAP----------PSLQ--------------- 355

Query: 346 TLKSPTNVSPNCPPAEATALPFSGPREPSLKQWPS-RVPQKQGGMGLASWSQLASTPRAP 404
           TL SP    P+  P   T  P   P  PSL+  P  +VP       L    Q   +P A 
Sbjct: 356 TLPSPPATPPSQAPPSMTTPPMQAP--PSLQTIPPIQVPHSLTSPSL----QAPPSPLAL 409

Query: 405 GSRDARWERREPALRGAKDRLTIGKHLDMGSPQLRTRDRGWPSPRPEREKRTSQSARRPT 464
            S  A      P L+     LT+       S    +R    P   P  +   S  A  P 
Sbjct: 410 SSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPL 469

Query: 465 CTESRWKSEEEVESDDEYLALPARLTQVSSLVSY--LGSISTLVTLPTGDIKGQSPLEVS 522
            T         V      L +   L  +SSL S+     +S+L+           PLE  
Sbjct: 470 QT----SLSPAVSPLSSPLTIHP-LQALSSLASHSPQAPLSSLI---------MPPLETQ 515

Query: 523 DSDGPASFPSSSSQSQLPP 541
            S  P S  +  +    PP
Sbjct: 516 SSLAPPSLQTPPASLTTPP 534



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 53/190 (27%), Positives = 63/190 (33%), Gaps = 28/190 (14%)

Query: 226 SSLEPVVPQEPSSVVGLGPRPQWSPQPVFSGGDASGLGRRRLSF------QAEYWACVLP 279
           S L    P+ PSS+    P PQ    P  +     GL    LS       QA     + P
Sbjct: 574 SPLTTPPPETPSSIAT--PPPQ--APPALASPPLQGLPSPPLSPLATPPPQAPPXLALPP 629

Query: 280 DSLPPSPDRHSPLWNPNKEYEDLLDYTYPLR-PGPQLPKHLDSRVPADPVLQDSGVDLDS 338
              PPSP    PL               PL  P PQ P  L   +   P        + +
Sbjct: 630 LQAPPSPPASPPL--------------SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA 675

Query: 339 FSVSPASTLKSPTNVSPNCPPAEATALPFSGPREP--SLKQWPSRVPQKQGGMGLASWSQ 396
               PAS   SP+   P+  P    A P   P  P  S    PS  P  Q    LA+   
Sbjct: 676 PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAA-PP 734

Query: 397 LASTPRAPGS 406
           L   P  P S
Sbjct: 735 LQVPPSPPAS 744



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 45/145 (31%), Positives = 50/145 (34%), Gaps = 23/145 (15%)

Query: 279 PDSLPPSPDRH---SPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDSRVP----------- 324
           P  +PPSP      SPL  P  +    L  T PL+  P  P     + P           
Sbjct: 765 PLQVPPSPPASLPMSPLAKPPPQAPPALA-TPPLQALPSPPASFPGQAPFSPSASLPMSP 823

Query: 325 -ADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPAEATALPFSGPR-----EPSLKQW 378
            A P  Q   V        P S   SPT  +P  PP        SGPR      P     
Sbjct: 824 LATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 883

Query: 379 PSRVPQKQ-GGMGLASWSQLA-STP 401
           PSR P     G  LA  S  A STP
Sbjct: 884 PSRSPSSTLSGPDLAGHSSSATSTP 908


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 104/427 (24%), Positives = 145/427 (33%), Gaps = 69/427 (16%)

Query: 4   GEEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPRLEAEGGLI------SPVWG 57
           GE    A+ +      S GR S   R    PGP+ G++  R+ AE  +       +P   
Sbjct: 91  GERAPPAKNTSPGPVSSPGRASGTTR----PGPL-GQKGLRISAEETVARGKATEAPKRS 145

Query: 58  AEGIPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGE 117
           A    A     G  PG PS A   ++  A  E    R  P+    PP T G    + S  
Sbjct: 146 ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPP-TEGPRKSVSSAS 204

Query: 118 SQVEKTKLSSSEEFPQT---LSLPRTTTICSGH---DADTEDDPSLADLPQALDLSQQPH 171
                    ++   P     L  P + ++ S      +     PS    P+A     QP 
Sbjct: 205 EHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPK 264

Query: 172 SSGLSCL---------SQWKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLA 222
             GL  L               L P S++  ++ S SA  + S+    Q    P     +
Sbjct: 265 PKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPS 324

Query: 223 KVSSSLEPVVPQEPSSVVGLGP-RPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDS 281
           + ++SL     Q   S +   P  P  +P P                 QA     + P  
Sbjct: 325 QATTSLGSPTLQATHSFLPSPPLSPLATPPP-----------------QAPPALALPPLQ 367

Query: 282 LPPSPDRH---SPLWNPNKEYEDLLD---YTYPLRPGPQLPKHLDSRVPADPVLQDSGVD 335
            PPSP      SPL  P+ +  + L       P  P P  P       PA P        
Sbjct: 368 APPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP-------- 419

Query: 336 LDSFSVSPASTLKSPTNVSPNCPPAEATALPFSGPREPSLKQWPSRVPQKQGGMGLASWS 395
                VSP++T  S    S   PP +   +P S P  P +   PS  P  Q    LA+  
Sbjct: 420 ----PVSPSATPPSQAPPSLAAPPLQ---VPPSPPASPPMS--PSATPPPQAPPPLAAPP 470

Query: 396 -QLASTP 401
            QLA  P
Sbjct: 471 LQLAKPP 477



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 97/347 (27%), Positives = 119/347 (34%), Gaps = 66/347 (19%)

Query: 81  PQASDANREPVAERSEPALSGLP--PATMGSGDLLLSGESQVEKTK-----------LSS 127
           P A+ +   P +  + P+L  LP  PAT  S      G   ++ T             + 
Sbjct: 294 PLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATP 353

Query: 128 SEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQA-----LDLSQQPHSSGLSCLSQWK 182
             + P  L+LP      S   A     P     PQA     + L Q P S   S      
Sbjct: 354 PPQAPPALALPPLQAPPSP-PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPS-----P 407

Query: 183 SVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSVVGL 242
            V +P S   P+S  +S S+T  S      +A P   SLA     + P  P  P      
Sbjct: 408 PVQAPFSP--PASPPVSPSATPPS------QAPP---SLAAPPLQVPPSPPASPPMSPSA 456

Query: 243 GPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYEDL 302
            P PQ +P P+     A  L   +   QA       P    PSP    P   P      L
Sbjct: 457 TPPPQ-APPPLA----APPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL 511

Query: 303 LDYTYPLR-PGPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPAE 361
                PL  P PQ P  L     A P+LQ            P S   SPT  +P  PP  
Sbjct: 512 P--MSPLATPPPQAPPVL-----AAPLLQ-----------VPPSPPASPTLQAPRRPPTP 553

Query: 362 ATALPFSGPR-----EPSLKQWPSRVPQKQ-GGMGLASWSQLA-STP 401
                 SGPR      P     PSR P     G  LA  S  A STP
Sbjct: 554 GPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTP 600


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 98/421 (23%), Positives = 143/421 (33%), Gaps = 70/421 (16%)

Query: 34   PGPMSGEQPPRL---EAEGGLISPVWGAEGIPAPTCWIGTDP-GGPSRAH---------- 79
            P P     PP       +GGL +P    +G P P       P GGP+ +           
Sbjct: 1258 PPPKGAPTPPAATPPSLKGGLATPPH--KGAPNPAVVTPPSPKGGPATSPPKGAPTPPAA 1315

Query: 80   ---QPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQVEKTKLSSSEEFPQTLS 136
                P+ S     P    + PA++  PP+  G+  L  +  S        SS+E P    
Sbjct: 1316 TPPSPKGSPGTPPPKGAPTPPAVT--PPSPKGTPTLPATTPSSKGGPTTPSSKEGPTP-- 1371

Query: 137  LPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLSCLSQWKSVLSPGS---AAQP 193
             P  T    G  A T   P     P        P S  +  LS  K+  +P +   AA P
Sbjct: 1372 -PAATPSHKGGPAMTPPSPKRG--PAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATP 1428

Query: 194  SSCSISASS-TGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSVVGLGPRPQWSPQP 252
            S   ++  + T  SL+     + P+GG  A  SS  +P +P    +V    P+   +P+ 
Sbjct: 1429 SKGDLTPPAVTPVSLKKAPATSAPKGGP-ATPSSKGDPTLP----AVTPPSPKEPPAPKQ 1483

Query: 253  VFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYEDLLDYTYPLRPG 312
            V +               A     V+P S    P   S   +P      LL    P    
Sbjct: 1484 VATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLA 1543

Query: 313  PQ---LPKHLD----SRVPADPVLQDSGVDLDSFSVS---------------PASTLKSP 350
            P+   +P  +      + PA P  +++     S   S               P   L  P
Sbjct: 1544 PKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPP 1603

Query: 351  TNVSPN-----CPPAEATALPFSGPREPSLKQWPSRVPQKQGGMGLASWSQLASTPRAPG 405
               SP+      PPA     P  GP  P+ K  P+  P         + S L  +P +P 
Sbjct: 1604 AVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPP--------VTPSSLKDSPTSPA 1655

Query: 406  S 406
            S
Sbjct: 1656 S 1656



 Score = 33.1 bits (74), Expect = 0.98
 Identities = 78/333 (23%), Positives = 107/333 (32%), Gaps = 40/333 (12%)

Query: 90   PVAERSEPALSGLPPATMGSGDLLLSGESQVEKTKLSSSEEFPQTLSLPRTTTICSGHDA 149
            P+   S P +S +  + +    L   G      T  S +   P+    P   T  S    
Sbjct: 820  PIGNLSSP-VSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGV 878

Query: 150  DTEDD----PSLADLPQALDLSQQPHSSGLSCLSQWKSVLSPGSAAQ-PSSCSISASSTG 204
                     PS+ +LP   +    P       LS   S      A   P     S S  G
Sbjct: 879  TLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKG 938

Query: 205  SSLQGHQERAEPRGGSLAKVSSSLEPVVPQE-PSSVVG--LGPRPQWSPQPVFSGGDASG 261
            +          P+GG  A  S    P  P   P S  G    P P+ +P P  +   +  
Sbjct: 939  APTPPAATPPSPKGGP-ATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPK 997

Query: 262  LGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDS 321
             G    S +    A   P   PPSP + SP   P  +       + P    P  PK   +
Sbjct: 998  GGPATPSPKG---APTPPAVTPPSP-KGSPAATPFPK-----GASTPPAATPPSPKGSPA 1048

Query: 322  RVPADPVLQDSGVDLDSFSVSPASTLKSPTN--VSPNC-----PPAEATALPFSGPREPS 374
              P                 +PA+TL SP     +P+      PPA     P  GP  PS
Sbjct: 1049 ATPLPK----------GAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPS 1098

Query: 375  LKQWP----SRVPQKQGGMGLASWSQLASTPRA 403
             K  P    +  P  +GG+         +TP A
Sbjct: 1099 PKGAPMPPAATPPSPKGGLATPPHKGAPTTPAA 1131



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 84/339 (24%), Positives = 123/339 (36%), Gaps = 39/339 (11%)

Query: 132  PQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLSCLSQWKSVLSPGSAA 191
            PQ    P  T + +     +   PSL   P A      P +  +  +S   S L+P  A+
Sbjct: 714  PQNTCAPLATLVLAPEIPKSVPSPSL---PPA---GTPPGTKKVDGISH-TSALAP-VAS 765

Query: 192  QPSSCSIS---ASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSVVGLGP-RPQ 247
             P  C      AS+T SS       A+    S + +  S+ P   + P+     GP  P 
Sbjct: 766  SPKECPTEDSGASATASSKGTLTYLAD----SPSPLGVSVSPQTKRPPTKKGSAGPDTPI 821

Query: 248  WSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDS-LPPSP------DRHSPLWN-----P 295
             +     S  +AS L    LSFQ    +     S  PPSP         +PL       P
Sbjct: 822  GNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLP 881

Query: 296  NKEYE--DLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNV 353
             KE     +++  +P + GP  P     + PA  +   S     + + +P     SP+  
Sbjct: 882  PKETPTPSVVNLPFP-KEGPATPA--PKQAPALSMTSSSPKKARA-TPAPKGIPASPSPK 937

Query: 354  SPNCPPAEATALPFSGPREPSLKQWP----SRVPQKQGGMGLASWSQLASTPRAPGSRDA 409
                PPA     P  GP  PS K  P    +  P  +GG    S  + A TP A      
Sbjct: 938  GAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPS-PKGAPTPPAATPPSP 996

Query: 410  RWERREPALRGAKDRLTIGKHLDMGSPQLRTRDRGWPSP 448
            +     P+ +GA     +      GSP      +G  +P
Sbjct: 997  KGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTP 1035


>gi|33946327 nucleoporin 214kDa [Homo sapiens]
          Length = 2090

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 85/347 (24%), Positives = 124/347 (35%), Gaps = 46/347 (13%)

Query: 95   SEPALSGLPPATMGSGDLLLSGESQVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDD 154
            S+P+   +P ++  SG    S  +  E    SS    P   +L  T++         E  
Sbjct: 1261 SKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSS-------KLETP 1313

Query: 155  PS-LADL--PQALDLSQQPHSSGLSCLSQWKSVLSPGSAAQPSSCSISASSTGSSLQGHQ 211
            PS L +L  P +L        SGL       S      A+  S  S   + T     G  
Sbjct: 1314 PSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFN 1373

Query: 212  ERAEPRGG-------SLAKVSSSLEPVVPQEPSSVVGLGPRPQWSPQP---VFSGGDASG 261
              A P  G       + +  ++S+ P      SS    G  P  S      +  GG +  
Sbjct: 1374 FTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLS 1433

Query: 262  LGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWN--PNKEYEDLLDY----TYPLRPGPQL 315
             G+   SF ++     +P S PP     +PL    P   +  LL      + P+  G   
Sbjct: 1434 AGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRST 1493

Query: 316  PKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVS-PNCPPAEATALPFSGPREPS 374
             +   S +P  P   DS V     S S AS L+   +   P  PP  + ++     +EP 
Sbjct: 1494 EEATSSALPEKP--GDSEV-----SASAASLLEEQQSAQLPQAPPQTSDSV----KKEPV 1542

Query: 375  LKQWPSRVPQKQGGMGLASWSQLA----STPRAPGSRDARWERREPA 417
            L Q          G   +S S +A    +TP   G  DAR E   PA
Sbjct: 1543 LAQ----PAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPA 1585



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 42/172 (24%), Positives = 70/172 (40%), Gaps = 21/172 (12%)

Query: 69  GTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQVEKTKLSSS 128
           G+ P  P+ +  PQ  DA+         P+    P AT     LL +G +    +  SSS
Sbjct: 432 GSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFS---LLPAGGAPTVFSFGSSS 488

Query: 129 EEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLSCLSQWKSVLSPG 188
            +   T+               T + PS +    +   +  P  S  S +   K+ L+P 
Sbjct: 489 LKSSATV---------------TGEPPSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPT 533

Query: 189 SAAQPSSCSISASSTGSSLQGHQERAEPRG-GSLAKVSSSLEPVVPQEPSSV 239
            AA P + S ++ S GSS  G +   E     S++  + +++P  P   S+V
Sbjct: 534 PAASPVAPSAASFSFGSS--GFKPTLESTPVPSVSAPNIAMKPSFPPSTSAV 583


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 86/406 (21%), Positives = 145/406 (35%), Gaps = 56/406 (13%)

Query: 167  SQQPHSSGLSCLSQWKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSS 226
            S QP +   +   + +S  SP    +  + S  + S+ S     +    PR GS+    +
Sbjct: 801  SSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQA 860

Query: 227  SLEPVVPQEPSSVVGLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPP-- 284
            + + V PQ  S      P P+   +   S    SG    R+             S PP  
Sbjct: 861  NEQSVTPQRRSCFES-SPDPELKSRTP-SRHSCSGSSPPRVK-----------SSTPPRQ 907

Query: 285  SPDRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPA 344
            SP R S   +P  + + ++         P+   H  S  P+   +        S SVSP 
Sbjct: 908  SPSRSS---SPQPKVKAIIS--------PRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPC 956

Query: 345  STLKS--------------PTNVSPNCPPAEATALPFSG--------PREPSLKQWPSRV 382
            S ++S               T V P  PP ++ +   S         P  PSL    S  
Sbjct: 957  SNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPC 1016

Query: 383  PQKQGGMGLA-----SWSQLASTPRAPGSRDARWERREPALRGAKDRLTIGKHLDMGSPQ 437
            PQ++    L      S S  A    +    ++ +      L+G + + +     D  SP+
Sbjct: 1017 PQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKG-QSQTSPDHRSDTSSPE 1075

Query: 438  LRTRDRGWPSPRPEREKRTSQSARRPTCTESRWKSEEEVESD-DEYLALPARLTQVSSLV 496
            +R      PS + + +        R +   +   S   +  D  E+ A P   + +S   
Sbjct: 1076 VRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQ 1135

Query: 497  S-YLGSISTLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLPP 541
            S +    S+  T+ +  + GQS LE ++S    + P     +  PP
Sbjct: 1136 SRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPP 1181



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 96/418 (22%), Positives = 143/418 (34%), Gaps = 106/418 (25%)

Query: 58   AEGIPAPTCWIGTDPGGPSRAHQPQASDANREPVAER-SEPALSGLPPATMGSGDLLLSG 116
            +E  P+P+  +G     PS++  P A D  R PV    S+ +   +   T  +G   LS 
Sbjct: 2421 SERAPSPSSRMGQ---APSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLS- 2476

Query: 117  ESQVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLS 176
             S    T  SS+ +    LS+P                     +P + D+ + P S+G  
Sbjct: 2477 -SGAVATTTSSAGDHNGMLSVPAP------------------GVPHS-DVGEPPASTGAQ 2516

Query: 177  CLSQWKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEP 236
              S   + L P    + SS S S+SS+ SS       +   G S +    S  PV P+  
Sbjct: 2517 QPSAL-AALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPE-- 2573

Query: 237  SSVVGLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPN 296
               V L   P  +P P     +A   GR                  PP P          
Sbjct: 2574 ---VALKRVPSPTPAPK----EAVREGR------------------PPEP---------- 2598

Query: 297  KEYEDLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPN 356
                                       PA    + S     S S S +S+  S ++ S +
Sbjct: 2599 --------------------------TPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSS 2632

Query: 357  CPPAEATALPFSGPREPSLKQWPSRVPQKQGGMGLASWSQLASTPRAPGSRDARWERREP 416
               + +++   S    PS        P K G   L   +     P  PG      ERR  
Sbjct: 2633 SSSSSSSSSSSSSSSSPS--------PAKPGPQALPKPASPKKPP--PG------ERRSR 2676

Query: 417  ALRGAKDRLTIGKHLDMGSPQLRTRDRGWPSPRPEREKRTSQSARRPTCTESRWKSEE 474
            + R   D L   + L   SP  R R    PSPR ++   + + +RR    +SR  S +
Sbjct: 2677 SPRKPIDSLRDSRSLSY-SPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHK 2733



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 43/176 (24%), Positives = 66/176 (37%), Gaps = 27/176 (15%)

Query: 380 SRVPQKQGGMGLASWSQLASTPRAPGSRDARWERREPALRGAKDRLTIGKHLDMGSPQLR 439
           SR P ++G           S  R P  R  R   R PA RG + R    +     S  L 
Sbjct: 660 SRTPARRG----------RSRSRTPARRSGRSRSRTPARRG-RSRSRTPRRGRSRSRSLV 708

Query: 440 TRDRGWPSPRPEREKRTSQSARRPTCTESRWKSEEEVESDDEYLALPARLTQVSSLVSYL 499
            R R   S  P+R  R+  S+ R   + +  +      S +       + +++SS     
Sbjct: 709 RRGRS-HSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPE------MKKSRISS----- 756

Query: 500 GSISTLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLPPGAALQGSGDPEGQN 555
              S  ++ P    K +  L  S S    S P    +SQ PP  +  GS  P+ ++
Sbjct: 757 -RRSRSLSSPRSKAKSRLSLRRSLS---GSSPCPKQKSQTPPRRSRSGSSQPKAKS 808



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 53/234 (22%), Positives = 82/234 (35%), Gaps = 37/234 (15%)

Query: 338  SFSVSPASTLKSP---TNVSPNCPPAEATALPF-----SGPREPSLKQWPSRVPQKQGGM 389
            S S  P +  ++P   +  S + PP + +  P      S    P +K   S  P +QG +
Sbjct: 799  SGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVK---SGTPPRQGSI 855

Query: 390  GLASWSQLASTPRAPGSRDARWERREPALRGAKDRLTIGKHLDMGSPQLRTRDRGWPSPR 449
                 ++ + TP+    R       +P L+      T  +H   GS   R +    P   
Sbjct: 856  TSPQANEQSVTPQR---RSCFESSPDPELKSR----TPSRHSCSGSSPPRVKSSTPPRQS 908

Query: 450  PEREKRTSQSARRPTCTESRWKSEEEVESDDEYLA--LPARLTQVSSL----------VS 497
            P R        +       R  S     S     +   P R   VS             S
Sbjct: 909  PSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYS 968

Query: 498  YLGSISTLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLPPGAALQGSGDP 551
            + GS S     P   +K ++P   S S   + +P   +Q+  PPG +L GS  P
Sbjct: 969  HSGSSS-----PDTKVKPETPPRQSHSGSISPYPKVKAQT--PPGPSLSGSKSP 1015


>gi|45439357 elongin A2 [Homo sapiens]
          Length = 753

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 47/171 (27%), Positives = 66/171 (38%), Gaps = 17/171 (9%)

Query: 310 RPGPQLPKHLDSRVPADPVLQD--SGVDLDSFSVSPASTLKSPTN--VSPNCPPAEATAL 365
           RPGPQ P+   SR      LQD          + +P S   SP +   +   PP +    
Sbjct: 84  RPGPQDPEESASRQRFGEALQDQEKAWGFPENATAPRSPSHSPEHRRTARRTPPGQQRPH 143

Query: 366 PFSGPREPSLKQWPSRVPQKQGGMGLASWSQLASTPRAPGSRDARWERREPALRGAKDRL 425
           P S  REP  ++   R+     G   AS ++ A   R P       E  EPA  G K   
Sbjct: 144 PRSHSREPRAERKCPRIAPADSGRYRASPTRTAPL-RMP-------EGPEPAAPG-KQPG 194

Query: 426 TIGKHLDMGSPQLRTRDRGWPSPRP----EREKRTSQSARRPTCTESRWKS 472
               H   G P L    +G P  +      +  ++S+  +RP C +  W S
Sbjct: 195 RGHTHAAQGGPLLCPGCQGQPQGKAVVSHSKGHKSSRQEKRPLCAQGDWHS 245


>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
          Length = 1612

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 103/416 (24%), Positives = 137/416 (32%), Gaps = 92/416 (22%)

Query: 201  SSTGSSLQGHQERAEP---RGGSLAKVSSSLEPVVPQ--EPSSVVGLGPRPQWSPQPVFS 255
            SST S+L G            G +   S+ +E ++PQ  +PSS  GLG  P  SP     
Sbjct: 1031 SSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSP----- 1085

Query: 256  GGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYEDLLDYTYPLRPGPQL 315
                                            R SP  +P            P+   P  
Sbjct: 1086 --------------------------------RTSPCQSPTISEG-------PVPSLPIR 1106

Query: 316  PKHLDSRVPADPVLQDSGVDLDSFS----VSPASTL--KSPTNVSPNCPPAEATALPFSG 369
            P    SR P  P  Q S +D    +      PA  L  K P    P  PP      P   
Sbjct: 1107 PSRAPSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPA--PPQR 1164

Query: 370  PREPSLKQWPSRVPQKQGGMGLASWSQLASTPRAPGSRDARWERREPALRGAKDRLTIGK 429
            P  PS  + P+   ++ GG+G          P +PG   AR E   P   G   +  IG+
Sbjct: 1165 PPPPSGARSPAPTRKEFGGIG---------APPSPGV--ARREMEAPKSPGTTRKDNIGR 1213

Query: 430  HLDMGSPQLRTRDRGWPSPRPEREKRTSQSARRPTCTESRWKSEEEVESDDEYLALPARL 489
                 SPQ      G   P P        S  RPT      ++           A   RL
Sbjct: 1214 --SQPSPQ-----AGLAGPGP-----AGYSTARPTIPP---RAGVISAPQSHARASAGRL 1258

Query: 490  TQVS-SLVSYLGSISTLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLPPGAALQGS 548
            T  S S  S     ST +  P   +K Q+      S  P   P+   Q  L P AA    
Sbjct: 1259 TPESQSKTSETSKGSTFLPEP---LKPQAAFPPQSSLPP---PAQRLQEPLVPVAAPMPQ 1312

Query: 549  GDPEGQNPCFLRSFVRAHDSAGEGSLGSSQALGVSSGLLKTRPSLPARLDRWPFSD 604
              P+       +   R+  S    S  SSQ    ++G+   +   P ++D  PF D
Sbjct: 1313 SGPQPNLETPPQPPPRSRSSHSLPSEASSQPQVKTNGISDGKRESPLKID--PFED 1366


>gi|92859678 small nuclear RNA activating complex, polypeptide 4,
           190kDa [Homo sapiens]
          Length = 1469

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 33/96 (34%), Positives = 44/96 (45%), Gaps = 24/96 (25%)

Query: 167 SQQPHSSGLSCLSQWKSVLSPGS-----------AAQPSSCSISASSTGSSLQGHQERAE 215
           S+ PH SG  CLS+WK ++               + + SS S S SS+GSS         
Sbjct: 481 SELPHRSGSQCLSKWKIMMGKKQGLRRRRRRARHSVRWSSTSSSGSSSGSS--------- 531

Query: 216 PRGGSLAKVSSSLEPVVPQEPSSVVGLGPRPQWSPQ 251
             GGS +  SSS E   P++  +  G G R   SPQ
Sbjct: 532 --GGSSSSSSSSSEEDEPEQAQA--GEGDRALLSPQ 563


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 39.7 bits (91), Expect = 0.010
 Identities = 116/588 (19%), Positives = 198/588 (33%), Gaps = 113/588 (19%)

Query: 2   ALGEEKAEAEASEDTKAQSYGRGSCR--ERELDIPGPM---------SGEQPPRLEAEGG 50
           A G  + +A AS      S+   S +  ER+L   GP+         S +     E E  
Sbjct: 37  ATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEE 96

Query: 51  LISPVWGAEGIPAPTCWIGTDPG-GPSRAHQPQASDANREPVAE---RSEPALSGLPPAT 106
           +  P      +PA    +G  PG   ++A +  +S+ + +   E   + +P   G+ P  
Sbjct: 97  VQGPPAKKAAVPAKR--VGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQA 154

Query: 107 MGSGDLLLSGESQVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDL 166
             +       ++  +K K S S+                  D+ +ED+P           
Sbjct: 155 KAA-------KAPPKKAKSSDSDS-----------------DSSSEDEPPK--------- 181

Query: 167 SQQPHSSGLSCLSQWKSVLSPGSAAQP--SSCSISASSTGSSLQGHQERAEPRGGSLAKV 224
           +Q+P  + ++  +Q K+   P  AA    +  + S+SS+ SS     +  E +  +  K 
Sbjct: 182 NQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKK 241

Query: 225 SSSLEPVVPQEPSSVVGLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPP 284
           +   + VV + P        R   S +   S  D     ++ +  +   ++ V P S PP
Sbjct: 242 TVPKKQVVAKAPVKAATTPTRKSSSSED--SSSDEEEEQKKPMKNKPGPYSSVPPPSAPP 299

Query: 285 SPDRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSGVDLDSFSVS-- 342
                     P K              G Q PK    +       +DS  + DS S    
Sbjct: 300 ----------PKKSL------------GTQPPKKAVEKQQPVESSEDSSDESDSSSEEEK 337

Query: 343 --PASTLKSPTNVSPNCPPAEATALPFSGPREPSLKQWPSRVPQKQGGMGLASWSQLAST 400
             P   + S     P  PPA+  A   S   +    +     P K  G    S ++ A T
Sbjct: 338 KPPTKAVVSKATTKP--PPAKKAAESSSDSSDSDSSE-DDEAPSKPAGTTKNSSNKPAVT 394

Query: 401 PRAPGSRDARWERREPALRGAK------DRLTIGKHLDMGSPQLRTRDRGWPSPRPEREK 454
            ++P  + A    ++P   G K      D  +  +       +   +      P+   + 
Sbjct: 395 TKSPAVKPAA-APKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKA 453

Query: 455 RTSQSAR------RPTCTESRWKSEEEVESDDEYLALPARLTQVSSLVSYLGSISTLVTL 508
             S  A+      R + ++S   S EE E      A+  +  +V+               
Sbjct: 454 ALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVA--------------- 498

Query: 509 PTGDIKGQSPLEVSDSDGPASFPSSSSQSQLPPGAALQGSGDPEGQNP 556
             G      P         +S  SSS  S       L+G G P  Q P
Sbjct: 499 --GGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAP 544


>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
            [Homo sapiens]
          Length = 3321

 Score = 39.3 bits (90), Expect = 0.014
 Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 4/86 (4%)

Query: 636  ELICWLYNVADV----TDHGTAARSNLTSLKSSLQLYRQFKKDIDEHQSLTESVLQKGEI 691
            +LI WL +  D     T         L  ++  L  + +F K++D   SL  SVL  G  
Sbjct: 1330 DLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQ 1389

Query: 692  LLQCLLENTPVLEDVLGRIAKQSGEL 717
            LL+    +T  L   L RI  Q  +L
Sbjct: 1390 LLRLKKVDTATLRSELSRIDSQWTDL 1415


>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
            [Homo sapiens]
          Length = 8749

 Score = 39.3 bits (90), Expect = 0.014
 Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 4/86 (4%)

Query: 636  ELICWLYNVADV----TDHGTAARSNLTSLKSSLQLYRQFKKDIDEHQSLTESVLQKGEI 691
            +LI WL +  D     T         L  ++  L  + +F K++D   SL  SVL  G  
Sbjct: 6735 DLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQ 6794

Query: 692  LLQCLLENTPVLEDVLGRIAKQSGEL 717
            LL+    +T  L   L RI  Q  +L
Sbjct: 6795 LLRLKKVDTATLRSELSRIDSQWTDL 6820



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 21/77 (27%), Positives = 35/77 (45%), Gaps = 2/77 (2%)

Query: 616  GEQGKESLVQCVKTFCCQLEELICWLYNVADVTDHGTAARSNLTSLKSSLQLYRQFKKDI 675
            G Q KE ++Q  + F     +   WL N    T        N++ + +SLQ  ++F  + 
Sbjct: 3064 GCQNKEQILQ--QRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSES 3121

Query: 676  DEHQSLTESVLQKGEIL 692
            +  Q     +L KGE+L
Sbjct: 3122 ENGQHKLNMMLSKGELL 3138


>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
            [Homo sapiens]
          Length = 8797

 Score = 39.3 bits (90), Expect = 0.014
 Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 4/86 (4%)

Query: 636  ELICWLYNVADV----TDHGTAARSNLTSLKSSLQLYRQFKKDIDEHQSLTESVLQKGEI 691
            +LI WL +  D     T         L  ++  L  + +F K++D   SL  SVL  G  
Sbjct: 6806 DLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQ 6865

Query: 692  LLQCLLENTPVLEDVLGRIAKQSGEL 717
            LL+    +T  L   L RI  Q  +L
Sbjct: 6866 LLRLKKVDTATLRSELSRIDSQWTDL 6891



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 21/77 (27%), Positives = 35/77 (45%), Gaps = 2/77 (2%)

Query: 616  GEQGKESLVQCVKTFCCQLEELICWLYNVADVTDHGTAARSNLTSLKSSLQLYRQFKKDI 675
            G Q KE ++Q  + F     +   WL N    T        N++ + +SLQ  ++F  + 
Sbjct: 3057 GCQNKEQILQ--QRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSES 3114

Query: 676  DEHQSLTESVLQKGEIL 692
            +  Q     +L KGE+L
Sbjct: 3115 ENGQHKLNMMLSKGELL 3131


>gi|55769533 PRKC, apoptosis, WT1, regulator [Homo sapiens]
          Length = 340

 Score = 38.9 bits (89), Expect = 0.018
 Identities = 42/185 (22%), Positives = 62/185 (33%), Gaps = 16/185 (8%)

Query: 58  AEGIPAP---TCWIGTD------PGGPSRAHQPQASDANREPVAERSEPALSGLPPATMG 108
           A  +P P    C +G+       PG      +P A+ A+  P  +R E    G+P     
Sbjct: 80  APAVPGPGGVNCAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKS 139

Query: 109 SGDLLLSGESQVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQ 168
           SG     G+ Q+EK KL         +++P     C     D E          A+    
Sbjct: 140 SGPSARKGKGQIEKRKLREKRRSTGVVNIPAAE--CLDEYEDDEAGQKERKREDAITQQN 197

Query: 169 QPHSSGLSCLSQWKSVL-----SPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAK 223
              +  ++ L    S L        S    S+ S+S     S          PR    A 
Sbjct: 198 TIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDAN 257

Query: 224 VSSSL 228
           VS +L
Sbjct: 258 VSGTL 262


>gi|46409266 coiled-coil domain containing 74B [Homo sapiens]
          Length = 380

 Score = 38.5 bits (88), Expect = 0.023
 Identities = 41/168 (24%), Positives = 63/168 (37%), Gaps = 27/168 (16%)

Query: 57  GAEGIPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSG 116
           GA  +     W+  +PGGPS A   + S     P  +    A  G         D L + 
Sbjct: 114 GARWVCINGVWV--EPGGPSPARLKEGSSRTHRPGGKHGRLA-GGSADTVRSPADSLSTS 170

Query: 117 ESQVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQP--HSSG 174
             Q  K+  +S +  PQ  S  +                S AD+PQ  DL ++P  H+S 
Sbjct: 171 SFQSVKSISNSGKARPQPGSFNK--------------QDSKADVPQKADLEEEPLLHNSK 216

Query: 175 LSCLSQWKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLA 222
           L  +        PG   Q       AS+ G++  G+ +    + G+ A
Sbjct: 217 LDKV--------PGVQGQARKEKAEASNAGAACMGNSQHQGRQMGAAA 256


>gi|239740972 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 389

 Score = 38.1 bits (87), Expect = 0.030
 Identities = 85/337 (25%), Positives = 122/337 (36%), Gaps = 66/337 (19%)

Query: 62  PAPTCW--IGTDPGGPSRAHQPQASDANREPVAERSEPALSGL--PPATMGSGDLLLSGE 117
           PAP  W  +   P  P   + P          A+ S PA + L  P A + +   LL  +
Sbjct: 96  PAPASWWPLQAQPLPPVSLYSPNVC-----LTADSSRPASTSLWTPQAKLPTFQQLLHTQ 150

Query: 118 SQVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLSC 177
                     S  F  T + P  T +           PSLA   + L +SQQP  +    
Sbjct: 151 LLPPSGLFRPSSCF--TRAFPGPTFVSW--------QPSLA---RFLPVSQQPRQA---- 193

Query: 178 LSQWKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEP--RGGSLAKVSSSLEPVVPQE 235
                 VL     +  S C   AS   + + GH  RA+   +  SL   ++S  P+  Q 
Sbjct: 194 -----QVLPHTGLSTSSLCLTVASPRPTPVPGHHLRAQNLLKSDSLVPTAASWWPMKAQN 248

Query: 236 PSSVVGLGPRP----QWSPQPVFSGGDASGLGRRRLSFQAE-------YWACVLPDSLPP 284
              +   GP P    +   QP+  GG +       L  QA+       +W    P S P 
Sbjct: 249 LLKLTCPGPAPASCQRLQAQPLPHGGFSRPTSSSWLGLQAQLLPHNSLFW----PSSCPA 304

Query: 285 SPDRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDSRVP-ADPVLQDSGV----DLDSF 339
           +  +  P  + ++  +  L     L PG       D R   A P L   G+     L S+
Sbjct: 305 NGGQCRPKTSSSQTLQAHL-----LLPGGINRPSFDLRTASAGPALASQGLFPGPALASW 359

Query: 340 SVSPASTLKSPTNVSPNCP-PAEATALPFSGPREPSL 375
            +  A  L       P C  P +A  LP SGP  P+L
Sbjct: 360 QLPQAKFL-------PACQQPQQAQLLPHSGPFRPNL 389


>gi|58530876 melanoma antigen family C, 1 [Homo sapiens]
          Length = 1142

 Score = 38.1 bits (87), Expect = 0.030
 Identities = 127/489 (25%), Positives = 183/489 (37%), Gaps = 88/489 (17%)

Query: 102 LPPATMGSGDLLLSGESQVEKTKLSSSEEFPQT-LSLPRTTTICSGHDADTEDDPSLAD- 159
           +P +   S  LL   +S  E+T  S+ E FPQ+ L +P T++  S   +  +  P  A  
Sbjct: 375 IPGSPSFSSTLLSLFQSSPERTH-STFEGFPQSPLQIPMTSSFSSTLLSILQSSPESAQS 433

Query: 160 ----LPQALDLSQQPHSSGLS--CLSQWKSVLSP--------GSAAQPSSCSISASSTGS 205
                PQ+    Q P SS  S   LS ++S  SP        G    P    +S+SS+ S
Sbjct: 434 AFEGFPQSP--LQIPVSSSFSYTLLSLFQS--SPERTHSTFEGFPQSPLQIPVSSSSSSS 489

Query: 206 SLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSVVGLGPRPQWSPQPVFSGGDASGLGRR 265
           +L    +       S  + + S     PQ P  +    P  + +  P+        L   
Sbjct: 490 TLLSLFQ-------SSPECTQSTFEGFPQSPLQIPQSPPEGENTHSPLQI---VPSLPEW 539

Query: 266 RLSFQAEYWACVLPDSLPPSPDRHSPLWNPNK--EYEDLLDYTYPLRPGPQLPKHLDSRV 323
             S    Y+    P S P   D  SP + P    + ED L   Y     PQ P+  DS  
Sbjct: 540 EDSLSPHYF----PQSPPQGEDSLSPHYFPQSPPQGEDSLSPHY----FPQSPQGEDSLS 591

Query: 324 P-----ADPVLQDSGVDLDSFSVSPA------STLKSPTNVSPNCPPA-------EATAL 365
           P     + P  +DS   L  F  SP       S+L+SP ++  +  P+       E++  
Sbjct: 592 PHYFPQSPPQGEDSMSPL-YFPQSPLQGEEFQSSLQSPVSICSSSTPSSLPQSFPESSQS 650

Query: 366 PFSGPREPSLKQWPSRVPQKQGGMGLASWSQLASTPRAPGSRDARWERREPALRGAKDRL 425
           P  GP +  L   P   P+     G+ S S L S   AP   D+    + P      +  
Sbjct: 651 PPEGPVQSPLHS-PQSPPE-----GMHSQSPLQSPESAPEGEDSLSPLQIPQSPLEGEDS 704

Query: 426 TIGKHLDMGSPQLRTRDRGWPSPR-PEREKRTSQSARRPT--CTESRWKS-----EEEVE 477
               H     P+          P+ P + +    S + P   C+ S   S      E  +
Sbjct: 705 LSSLHFPQSPPEWEDSLSPLHFPQFPPQGEDFQSSLQSPVSICSSSTSLSLPQSFPESPQ 764

Query: 478 SDDEYLALPARLTQVSSLVSYLGSISTLVTL-------PTGDIKG--QSPLEVSDSDGPA 528
           S  E  A       VSS  SY     TL +L       P    +G  QSPL+   S  P+
Sbjct: 765 SPPEGPAQSPLQRPVSSFFSY-----TLASLLQSSHESPQSPPEGPAQSPLQSPVSSFPS 819

Query: 529 SFPSSSSQS 537
           S  SS SQS
Sbjct: 820 STSSSLSQS 828



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 31/102 (30%), Positives = 46/102 (45%), Gaps = 12/102 (11%)

Query: 516 QSPLEVSDSDGPASFPSS-SSQSQLPPGAALQG-----SGDPEGQNPCFLRSFVRAHDSA 569
           QSP+ +  S  P+S P S    SQ PP   +Q         PEG +    +S +++ +SA
Sbjct: 626 QSPVSICSSSTPSSLPQSFPESSQSPPEGPVQSPLHSPQSPPEGMHS---QSPLQSPESA 682

Query: 570 GEGSLGSSQALGVSSGLLKTRPSLPARLDRWPFSDPDVEGQL 611
            EG   S   L +    L+   SL +    +P S P+ E  L
Sbjct: 683 PEGE-DSLSPLQIPQSPLEGEDSLSSL--HFPQSPPEWEDSL 721


>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
          Length = 1597

 Score = 38.1 bits (87), Expect = 0.030
 Identities = 96/452 (21%), Positives = 151/452 (33%), Gaps = 75/452 (16%)

Query: 3   LGEEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPRLEAEG---GLISPVWGAE 59
           LGEE+   + +++       +G  ++++  +   M G Q  R+   G   GL    W  E
Sbjct: 256 LGEEQMIEQVNDE-------KGEQKQKQEQVQDVMLGRQGERMGLTGEPEGLNDGEWEQE 308

Query: 60  GIPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQ 119
            +       G    G  R  + Q  + NR    +       G      G  +     E  
Sbjct: 309 DMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQEDHGIKEKG 368

Query: 120 VEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLSCLS 179
           V  +   + E  P++    R   +      + E++     +P  +     PH        
Sbjct: 369 VPVSGQEAKE--PESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCD------ 420

Query: 180 QWKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPV-VPQEPSS 238
                L PG           AS   + + G Q  +     S A +S SLEP+    +P S
Sbjct: 421 -----LFPG-----------ASYLMTQIPGTQTESRAEELSPAALSPSLEPIRCSHQPIS 464

Query: 239 VVGLGPRPQWSPQPVFSG----------GDASGLGRRRLSFQAEYWACVLPDSLPPSPDR 288
           ++G     +   + +             G  S  G   +   A       PDS PPSP  
Sbjct: 465 LLGSFLTEESPDKEIDQNSQQEESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAE 524

Query: 289 HSPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDS---RVP---ADPVLQDSGVDLDSFSVS 342
             P          +   +   RP    P+   S   R P   + P+  D      +  + 
Sbjct: 525 AYP----------ITPASVSARPPVAFPRRETSCAARAPETASAPLSMDDPSPCGTSEMC 574

Query: 343 PASTLKSP-TNVSPNCPPAEATAL-----PFSGPREPSLKQWPSRVPQKQGGMGLA-SWS 395
           PA+    P T  SP  PPA +T         S P     +Q P  V     GM L+ S S
Sbjct: 575 PAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLV-----GMLLSYSHS 629

Query: 396 QLASTPRAPGSRDARWERREPALRGAKDRLTI 427
           +L   P  P    +   RR+   R  +D  T+
Sbjct: 630 ELPQRPPKPAIYSSVTPRRD--RRSGRDYSTV 659


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 38.1 bits (87), Expect = 0.030
 Identities = 93/386 (24%), Positives = 137/386 (35%), Gaps = 56/386 (14%)

Query: 25  SCRERELDIP-GPMSGEQPPRLEAEGGLISP--VWGAEGIPAPTC-------WI-GTDPG 73
           S  +R L +P GP+     P  + +  L  P    G+EG  A  C       W+ G  PG
Sbjct: 506 SLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPG 565

Query: 74  GPSRAHQPQASDANREPVAE-RSEPALSGLPPATMGSGDLLLSGESQVEKTKLSSSEEFP 132
           G  R   P++ +    P +   S+     LPP  + +G     G++Q  K +  +S   P
Sbjct: 566 GSRRP--PRSPERTLSPSSGYSSQSGTPTLPPKGL-AGPPASPGKAQPPKPERVTSLRSP 622

Query: 133 QTLSLPRTTTICSGHDADTEDDPSLADLPQALD-----LSQQPHSSGLSCLSQWKSV-LS 186
                   T++CS   + ++  PS    PQ L          PH    +  S   S   S
Sbjct: 623 GASVSSSLTSLCS---SSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRS 679

Query: 187 PGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVV------PQEPSSVV 240
           P  AA   +         S+     +       +L  +  S  PV+      P  P    
Sbjct: 680 PNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQES--PVISKDQSPPPSPPPSY 737

Query: 241 GLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYE 300
              P P   P+ V     AS      L  Q   W    P   PP+P           E +
Sbjct: 738 HPPPPPTKKPEVVVEAPSASETAEEPL--QDPNW----PPPPPPAP-----------EEQ 780

Query: 301 DLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPA 360
           DL    +P  P  +    + S  PA P      V   + S S A+ L+     SP+ PPA
Sbjct: 781 DLSMADFP--PPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPA 838

Query: 361 EATALPFSGPREPSLKQWPSRVPQKQ 386
                P S     S     +++PQK+
Sbjct: 839 PPAPAPAS-----SAPGHVAKLPQKE 859


>gi|14249150 single stranded DNA binding protein 4 isoform a [Homo
           sapiens]
          Length = 385

 Score = 37.7 bits (86), Expect = 0.040
 Identities = 50/179 (27%), Positives = 64/179 (35%), Gaps = 30/179 (16%)

Query: 274 WACVLPDSLPPSPDRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSG 333
           W CV  D    +PDR     +   E +   DY+    P P +     S  P D +   +G
Sbjct: 63  WWCVFWDLYCAAPDRREACEHSG-EAKAFQDYSAAAAPSPVM----GSMAPGDTMA--AG 115

Query: 334 VDLDSFSVSPASTLKSPTNVSPNCPPAEATALPFSGPREPSLKQWPSRVPQKQGGMGLAS 393
                F   P  +  SP N  PN P       PF  PR P   +   R+P  Q   GL  
Sbjct: 116 SMAAGFFQGPPGSQPSPHN--PNAPMMGPHGQPFMSPRFPGGPRPTLRMP-SQPPAGLP- 171

Query: 394 WSQLASTPRAPGSRDARWERREPALRGAKDRLTIGKHLDMGSPQLR-TRDRGWPSPRPE 451
                S P  PG+ +       P  +G         H  MG P  R T  RG  S  P+
Sbjct: 172 ----GSQPLLPGAMEP-----SPRAQG---------HPSMGGPMQRVTPPRGMASVGPQ 212


>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
          Length = 727

 Score = 37.4 bits (85), Expect = 0.052
 Identities = 60/241 (24%), Positives = 87/241 (36%), Gaps = 29/241 (12%)

Query: 162 QALDLSQQPHSSGLSCLSQWKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSL 221
           +AL  S  P      C SQ  + L P SA  P++ S SA+S   +       A     + 
Sbjct: 293 EALRRSSTPIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAA-AHTAIASASTT 351

Query: 222 AKVSSSLEPVVPQEPSSVVGLGPRPQWSPQPVFSGGDASGLGRRRL----SFQAEYWACV 277
           A  SS  +   PQ  S    +      +    +S G A+   + R+    S +   +  V
Sbjct: 352 APASSPADSPRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPV 411

Query: 278 LPDSLPPSPDRH----------SPLWNPN--KEYEDLLDYTYPLRPGP-----------Q 314
              +  PSP  +          +P + P+    Y      TY   P P            
Sbjct: 412 PASTYSPSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNP 471

Query: 315 LPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPAEATALPFSGPREPS 374
            P    S  PA+P  +   V  DSFS   A   KS T++S    P    A   +GP+ P 
Sbjct: 472 APSVAYSGGPAEPASRPPWVTDDSFSQKFAPG-KSTTSISKQTLPRGGPAYTPAGPQVPP 530

Query: 375 L 375
           L
Sbjct: 531 L 531


>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
          Length = 1295

 Score = 37.0 bits (84), Expect = 0.068
 Identities = 81/359 (22%), Positives = 115/359 (32%), Gaps = 72/359 (20%)

Query: 201  SSTGSSLQGHQERAEP---RGGSLAKVSSSLEPVVPQ--EPSSVVGLGPRPQWSPQPVFS 255
            SST S+L G            G +   S+ +E ++PQ  +PSS  GLG  P  SP     
Sbjct: 992  SSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSP----- 1046

Query: 256  GGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYEDLLDYTYPLRPGPQL 315
                                            R SP  +P            P+   P  
Sbjct: 1047 --------------------------------RTSPCQSPTISEG-------PVPSLPIR 1067

Query: 316  PKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPAEATALPFSGPREPSL 375
            P    SR P  P  Q S +D       PA+ L       P  P       P + P  P+ 
Sbjct: 1068 PSRAPSRTPGPPSAQSSPID-----AQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAP 1122

Query: 376  KQWPSRVPQKQGGMGLASWSQLASTPRAPG-SRDARWERREPALRG----------AKDR 424
               P R P   G    A   +    P++PG +R     R +P+ +           +  R
Sbjct: 1123 ---PQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTAR 1179

Query: 425  LTIGKHLD-MGSPQLRTRDRGWPSPRPEREKRTSQSARRPTCTESRWKSEEEVESDDEYL 483
             TI      + +PQ   R        PE + +TS++++  T      K +         L
Sbjct: 1180 PTIPPRAGVISAPQSHARASA-GRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSS-L 1237

Query: 484  ALPARLTQVSSLVSYLGSISTLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLPPG 542
              PA+  Q   LV     +      P  +   Q P     S    S  SS  Q + P G
Sbjct: 1238 PPPAQRLQ-EPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPSG 1295


>gi|60097902 filaggrin [Homo sapiens]
          Length = 4061

 Score = 37.0 bits (84), Expect = 0.068
 Identities = 52/228 (22%), Positives = 83/228 (36%), Gaps = 11/228 (4%)

Query: 4    GEEKAEAEA-SEDTKAQSYG-RGSCRERELDIPGPMSGEQPPRLEAEGGLISPVWGAEGI 61
            G + +++E  SED+  QS    G     +        G    R    G  +  V   E  
Sbjct: 2365 GSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQS 2424

Query: 62   PAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQVE 121
             +     GT  GG   +H  QA D++R   ++  +  + G P ++  SG    S   Q+ 
Sbjct: 2425 ESAHGRTGTSTGGRQGSHHKQARDSSRHSTSQEGQDTIHGHPGSS--SGGRQGSHYEQLV 2482

Query: 122  KTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQ----QPHSSGLSC 177
                 S      T S  R+     GH           +  Q+ D S+    + H +    
Sbjct: 2483 DRSGHSGSHHSHTTSQGRSDA-SHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRA 2541

Query: 178  LSQWKSVLSPGSAAQPSSCSI--SASSTGSSLQGHQERAEPRGGSLAK 223
             S   S +  G +  P +     S+ S  S  QGH E +E   GS ++
Sbjct: 2542 DSSGHSQVGQGQSEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSASR 2589



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 52/228 (22%), Positives = 84/228 (36%), Gaps = 11/228 (4%)

Query: 4   GEEKAEAEA-SEDTKAQSY-GRGSCRERELDIPGPMSGEQPPRLEAEGGLISPVWGAEGI 61
           G + +++E  SE++  QS  G G    R+        G    R    G  +  V   E  
Sbjct: 419 GSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQP 478

Query: 62  PAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQVE 121
            +     GT  GG   +H  QA D++R   ++  +  + G P ++ G G      E  V 
Sbjct: 479 DSAHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRG-GRQGSHHEQSVN 537

Query: 122 KTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALD----LSQQPHSSGLSC 177
           ++  S S     T S  R+     G            +  Q+ D       + H +    
Sbjct: 538 RSGHSGSHH-SHTTSQGRSDA-SHGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQA 595

Query: 178 LSQWKSVLSPGSAAQPSSCSISASSTG--SSLQGHQERAEPRGGSLAK 223
            S   S +  G ++ P +     SS    S  QGH E +E   GS ++
Sbjct: 596 DSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASR 643



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 53/231 (22%), Positives = 87/231 (37%), Gaps = 17/231 (7%)

Query: 4    GEEKAEAEA-SEDTKAQSYGR----GSCRERELDIPGPMSGEQPPRLEAEGGLISPVWGA 58
            G + +++E  SED+  QS       G  ++   +     SGE   R    G  +  V   
Sbjct: 2041 GSQASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQSGESSGR---SGSFLYQVSTH 2097

Query: 59   EGIPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGES 118
            E   +         GG   +H  QA D++R   ++  +  + G P  + G G      E 
Sbjct: 2098 EQSESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGHPGPSRG-GRQGSHQEQ 2156

Query: 119  QVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQP----HSSG 174
             V+++  S S     T S  R+     G            D  Q+ D S+      H + 
Sbjct: 2157 SVDRSGHSGSHH-SHTTSQGRSDA-SRGQSGSRSASRKTYDKEQSGDGSRHSGSHHHEAS 2214

Query: 175  LSCLSQWKSVLSPGSAAQPSSCSISASSTG--SSLQGHQERAEPRGGSLAK 223
                S   S++  G ++ P +     SS    S  +GH E +E R GS ++
Sbjct: 2215 SWADSSRHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSERRSGSASR 2265


>gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens]
          Length = 2382

 Score = 37.0 bits (84), Expect = 0.068
 Identities = 98/443 (22%), Positives = 157/443 (35%), Gaps = 93/443 (20%)

Query: 4   GEEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPRLEAEGGLISPV-------W 56
           G+ K  A+A +D       R S  +R+ +    +  EQ  + + E  L   V        
Sbjct: 549 GDHKTMAKAIKD-------RVSLIKRKREQRQLVREEQEKKKQEESSLKQQVEQSSASQT 601

Query: 57  GAEGIPAPTCWI---GTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLL 113
           G + +P+ +  I    T     S   +P+  +A++    +  +P++S L   T+ SG   
Sbjct: 602 GIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQ-- 659

Query: 114 LSGESQVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSS 173
             G S   ++++SS +          T +  S H+           +P  +    QPH  
Sbjct: 660 --GSSVFTESRVSSQQ----------TVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHG- 706

Query: 174 GLSCLSQWKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVP 233
                     V  P S AQ                  Q + +P   SL  VSSS     P
Sbjct: 707 ----------VYPPSSVAQG-----------------QSQGQPSSSSLTGVSSSQPIQHP 739

Query: 234 QEPSSVVGLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPD-----SLPPS--- 285
           Q+   +    P PQ + Q   S    S                VLP       LP S   
Sbjct: 740 QQQQGIQQTAP-PQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPV 798

Query: 286 ---------PDRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDSRVP-ADPVLQDSGVD 335
                    P    P   P       L    PL P P LP++  S++P + P +  +   
Sbjct: 799 PTIQGEPQIPVATQPSVVPVHSGAHFLPVGQPL-PTPLLPQYPVSQIPISTPHVSTAQTG 857

Query: 336 LDSFSVSPASTLKSP-----TNVSPNCPPAEATALPFSGPR--EPSLKQWPSRV-PQ--- 384
             S  ++ A+ +  P     ++ +    P  +T +P   P   +P + Q PS+V PQ   
Sbjct: 858 FSSLPITMAAGITQPLLTLASSATTAAIPGVSTVVPSQLPTLLQP-VTQLPSQVHPQLLQ 916

Query: 385 -KQGGMGL-ASWSQLASTPRAPG 405
                MG+ A+  Q A  P + G
Sbjct: 917 PAVQSMGIPANLGQAAEVPLSSG 939


>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
          Length = 2157

 Score = 37.0 bits (84), Expect = 0.068
 Identities = 59/252 (23%), Positives = 79/252 (31%), Gaps = 21/252 (8%)

Query: 5   EEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPRLEAEGGLISPVWGAEGIPAP 64
           E        E+ + Q   R +C E+ L       G    RL+AE         A   PAP
Sbjct: 465 ERARRRREEEERRMQEERRAACAEK-LKRLDEKFGAPDKRLKAEPAAPP---AAPSTPAP 520

Query: 65  TCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQVEKTK 124
              +  +   P       A     EP      P     P   + +   L+SG      T 
Sbjct: 521 PPAVPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTS 580

Query: 125 LSSSEEFPQTLSLPRTTTICSGHDA---DTEDDPSLADLPQALDLSQQPHSSGLSCLSQW 181
             S E  P    LP         +     T   P +      +  ++QP S GL      
Sbjct: 581 SGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQ 640

Query: 182 KSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSV-V 240
           KS L P    Q     +         Q HQ +   +G      S+   PV P  P  V +
Sbjct: 641 KS-LPPRFQRQQQEQLLKQQ------QQHQWQQHQQG------SAPPTPVPPSPPQPVTL 687

Query: 241 GLGPRPQWSPQP 252
           G  P PQ  P P
Sbjct: 688 GAVPAPQAPPPP 699



 Score = 33.5 bits (75), Expect = 0.75
 Identities = 49/208 (23%), Positives = 73/208 (35%), Gaps = 40/208 (19%)

Query: 354 SPNCPP-------AEATALPFSGPREPSLKQWPSRVPQKQGGMGLASWSQLAS------- 399
           SPN  P       AE +  P + P  P+ K  P   P  +G  G  +W            
Sbjct: 380 SPNSEPPTPKTAWAETSRPPETEPGPPAPK--PPLPPPHRGPAG--NWGPPGDYPDRGGP 435

Query: 400 --TPRAPGSRDARWERREPALRGAKDRLTIGKHLDMGSPQLRTRDRGWPSPRPEREKRTS 457
              P AP   D  W +R         R      + +   + R R         E E+R  
Sbjct: 436 PCKPPAPEDEDEAWRQR---------RKQSSSEISLAVERARRRR--------EEEERRM 478

Query: 458 QSARRPTCTESRWKSEEEVESDDEYL-ALPARLTQVSSLVSYLGSISTLVTLPTGDIKGQ 516
           Q  RR  C E   + +E+  + D+ L A PA      S  +   ++   +  P       
Sbjct: 479 QEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPAS 538

Query: 517 SPLEVSDSDGPASFPSSSSQSQLPPGAA 544
           +P   ++ + PA  P   +QS   PG A
Sbjct: 539 APTPETEPEEPAQAP--PAQSTPTPGVA 564


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.129    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,848,787
Number of Sequences: 37866
Number of extensions: 2074830
Number of successful extensions: 8363
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 250
Number of HSP's that attempted gapping in prelim test: 7835
Number of HSP's gapped (non-prelim): 834
length of query: 757
length of database: 18,247,518
effective HSP length: 110
effective length of query: 647
effective length of database: 14,082,258
effective search space: 9111220926
effective search space used: 9111220926
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.