Guide to the Human Genome
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Search of human proteins with 148886654

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148886654 polydom [Homo sapiens]
         (3571 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148886654 polydom [Homo sapiens]                                  7698   0.0  
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi...   675   0.0  
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi...   674   0.0  
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap...   521   e-147
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap...   521   e-147
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]          505   e-142
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa...   474   e-133
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]           445   e-124
gi|54792123 complement component (3d/Epstein Barr virus) recepto...   401   e-111
gi|42544177 complement component (3d/Epstein Barr virus) recepto...   372   e-102
gi|62739186 complement factor H isoform a precursor [Homo sapiens]    318   8e-86
gi|148833508 notch1 preproprotein [Homo sapiens]                      272   5e-72
gi|24041035 notch 2 preproprotein [Homo sapiens]                      271   1e-71
gi|134244285 Notch homolog 3 [Homo sapiens]                           265   5e-70
gi|157419154 selectin P precursor [Homo sapiens]                      255   5e-67
gi|41327708 crumbs homolog 1 precursor [Homo sapiens]                 251   1e-65
gi|4557679 jagged 1 precursor [Homo sapiens]                          248   1e-64
gi|55770876 notch4 preproprotein [Homo sapiens]                       237   2e-61
gi|110735443 delta-like 1 [Homo sapiens]                              236   2e-61
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]               235   7e-61
gi|112420992 crumbs homolog 2 [Homo sapiens]                          231   1e-59
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]               225   5e-58
gi|116235485 delta-notch-like EGF repeat-containing transmembran...   224   2e-57
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]               223   2e-57
gi|4502503 complement component 4 binding protein, alpha chain p...   218   1e-55
gi|9506545 delta-like 4 protein precursor [Homo sapiens]              217   1e-55
gi|188528675 slit homolog 1 [Homo sapiens]                            211   1e-53
gi|122937283 6720455I24Rik homolog [Homo sapiens]                     204   1e-51
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ...   197   1e-49
gi|187960042 selectin E precursor [Homo sapiens]                      196   5e-49

>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score = 7698 bits (19974), Expect = 0.0
 Identities = 3571/3571 (100%), Positives = 3571/3571 (100%)

Query: 1    MWPRLAFCCWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSR 60
            MWPRLAFCCWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSR
Sbjct: 1    MWPRLAFCCWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSR 60

Query: 61   VERLGQAFRRRVRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTAT 120
            VERLGQAFRRRVRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTAT
Sbjct: 61   VERLGQAFRRRVRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTAT 120

Query: 121  RVAIVTFSSKNYVVPRVDYISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQIL 180
            RVAIVTFSSKNYVVPRVDYISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQIL
Sbjct: 121  RVAIVTFSSKNYVVPRVDYISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQIL 180

Query: 181  LHARENSTKVVFLITDGYSNGGDPRPIAASLRDSGVEIFTFGIWQGNIRELNDMASTPKE 240
            LHARENSTKVVFLITDGYSNGGDPRPIAASLRDSGVEIFTFGIWQGNIRELNDMASTPKE
Sbjct: 181  LHARENSTKVVFLITDGYSNGGDPRPIAASLRDSGVEIFTFGIWQGNIRELNDMASTPKE 240

Query: 241  EHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHT 300
            EHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHT
Sbjct: 241  EHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHT 300

Query: 301  GHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDC 360
            GHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDC
Sbjct: 301  GHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDC 360

Query: 361  VCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILC 420
            VCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILC
Sbjct: 361  VCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILC 420

Query: 421  LPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC 480
            LPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC
Sbjct: 421  LPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC 480

Query: 481  QGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKE 540
            QGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKE
Sbjct: 481  QGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKE 540

Query: 541  MLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEK 600
            MLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEK
Sbjct: 541  MLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEK 600

Query: 601  VSVHVHPAFTPPYLFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQ 660
            VSVHVHPAFTPPYLFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQ
Sbjct: 601  VSVHVHPAFTPPYLFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQ 660

Query: 661  VSEKVHAASWDEPQFSDNSGAELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHI 720
            VSEKVHAASWDEPQFSDNSGAELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHI
Sbjct: 661  VSEKVHAASWDEPQFSDNSGAELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHI 720

Query: 721  VIKGSPCEIPFTPVNGDFICTPDNTGVNCTLTCLEGYDFTEGSTDKYYCAYEDGVWKPTY 780
            VIKGSPCEIPFTPVNGDFICTPDNTGVNCTLTCLEGYDFTEGSTDKYYCAYEDGVWKPTY
Sbjct: 721  VIKGSPCEIPFTPVNGDFICTPDNTGVNCTLTCLEGYDFTEGSTDKYYCAYEDGVWKPTY 780

Query: 781  TTEWPDCAKKRFANHGFKSFEMFYKAARCDDTDLMKKFSEAFETTLGKMVPSFCSDAEDI 840
            TTEWPDCAKKRFANHGFKSFEMFYKAARCDDTDLMKKFSEAFETTLGKMVPSFCSDAEDI
Sbjct: 781  TTEWPDCAKKRFANHGFKSFEMFYKAARCDDTDLMKKFSEAFETTLGKMVPSFCSDAEDI 840

Query: 841  DCRLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSYDDFLDTVQETATSIGNAKS 900
            DCRLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSYDDFLDTVQETATSIGNAKS
Sbjct: 841  DCRLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSYDDFLDTVQETATSIGNAKS 900

Query: 901  SRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKLKRTLNKD 960
            SRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKLKRTLNKD
Sbjct: 901  SRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKLKRTLNKD 960

Query: 961  PMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRI 1020
            PMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRI
Sbjct: 961  PMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRI 1020

Query: 1021 GSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPK 1080
            GSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPK
Sbjct: 1021 GSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPK 1080

Query: 1081 FGSRSCLSCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFC 1140
            FGSRSCLSCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFC
Sbjct: 1081 FGSRSCLSCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFC 1140

Query: 1141 LACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFN 1200
            LACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFN
Sbjct: 1141 LACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFN 1200

Query: 1201 PCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSG 1260
            PCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSG
Sbjct: 1201 PCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSG 1260

Query: 1261 YTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNA 1320
            YTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNA
Sbjct: 1261 YTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNA 1320

Query: 1321 VCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHC 1380
            VCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHC
Sbjct: 1321 VCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHC 1380

Query: 1381 ELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVM 1440
            ELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVM
Sbjct: 1381 ELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVM 1440

Query: 1441 LDGMLPSLHALTCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGREKIT 1500
            LDGMLPSLHALTCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGREKIT
Sbjct: 1441 LDGMLPSLHALTCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGREKIT 1500

Query: 1501 NCPSVNDGRWHHIAITWTSANGIWKVYIDGKLSDGGAGLSVGLPIPGGGALVLGQEQDKK 1560
            NCPSVNDGRWHHIAITWTSANGIWKVYIDGKLSDGGAGLSVGLPIPGGGALVLGQEQDKK
Sbjct: 1501 NCPSVNDGRWHHIAITWTSANGIWKVYIDGKLSDGGAGLSVGLPIPGGGALVLGQEQDKK 1560

Query: 1561 GEGFSPAESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVK 1620
            GEGFSPAESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVK
Sbjct: 1561 GEGFSPAESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVK 1620

Query: 1621 IDSKSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQ 1680
            IDSKSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQ
Sbjct: 1621 IDSKSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQ 1680

Query: 1681 PLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVS 1740
            PLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVS
Sbjct: 1681 PLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVS 1740

Query: 1741 PSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHS 1800
            PSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHS
Sbjct: 1741 PSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHS 1800

Query: 1801 SGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEE 1860
            SGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEE
Sbjct: 1801 SGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEE 1860

Query: 1861 LAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSG 1920
            LAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSG
Sbjct: 1861 LAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSG 1920

Query: 1921 LTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFT 1980
            LTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFT
Sbjct: 1921 LTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFT 1980

Query: 1981 FRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFG 2040
            FRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFG
Sbjct: 1981 FRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFG 2040

Query: 2041 DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKA 2100
            DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKA
Sbjct: 2041 DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKA 2100

Query: 2101 KFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGS 2160
            KFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGS
Sbjct: 2101 KFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGS 2160

Query: 2161 NYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTG 2220
            NYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTG
Sbjct: 2161 NYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTG 2220

Query: 2221 RIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENF 2280
            RIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENF
Sbjct: 2221 RIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENF 2280

Query: 2281 EVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTT 2340
            EVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTT
Sbjct: 2281 EVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTT 2340

Query: 2341 EVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHF 2400
            EVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHF
Sbjct: 2341 EVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHF 2400

Query: 2401 GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLS 2460
            GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLS
Sbjct: 2401 GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLS 2460

Query: 2461 TALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTV 2520
            TALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTV
Sbjct: 2461 TALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTV 2520

Query: 2521 TYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIY 2580
            TYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIY
Sbjct: 2521 TYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIY 2580

Query: 2581 SCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDM 2640
            SCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDM
Sbjct: 2581 SCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDM 2640

Query: 2641 MEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQ 2700
            MEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQ
Sbjct: 2641 MEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQ 2700

Query: 2701 EDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN 2760
            EDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN
Sbjct: 2701 EDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN 2760

Query: 2761 RKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKN 2820
            RKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKN
Sbjct: 2761 RKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKN 2820

Query: 2821 WDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWS 2880
            WDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWS
Sbjct: 2821 WDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWS 2880

Query: 2881 GATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAE 2940
            GATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAE
Sbjct: 2881 GATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAE 2940

Query: 2941 IPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSP 3000
            IPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSP
Sbjct: 2941 IPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSP 3000

Query: 3001 SCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCE 3060
            SCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCE
Sbjct: 3001 SCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCE 3060

Query: 3061 HTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPL 3120
            HTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPL
Sbjct: 3061 HTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPL 3120

Query: 3121 SCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKK 3180
            SCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKK
Sbjct: 3121 SCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKK 3180

Query: 3181 CPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVS 3240
            CPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVS
Sbjct: 3181 CPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVS 3240

Query: 3241 CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCE 3300
            CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCE
Sbjct: 3241 CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCE 3300

Query: 3301 TPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVP 3360
            TPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVP
Sbjct: 3301 TPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVP 3360

Query: 3361 FVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPA 3420
            FVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPA
Sbjct: 3361 FVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPA 3420

Query: 3421 HVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGG 3480
            HVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGG
Sbjct: 3421 HVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGG 3480

Query: 3481 ICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPC 3540
            ICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPC
Sbjct: 3481 ICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPC 3540

Query: 3541 LNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF 3571
            LNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF
Sbjct: 3541 LNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF 3571


>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
          Length = 2039

 Score =  675 bits (1742), Expect = 0.0
 Identities = 551/2009 (27%), Positives = 799/2009 (39%), Gaps = 292/2009 (14%)

Query: 1651 GSKVNLFCDPGFQLVGNPVQY-CLNQGQWTQPLPHCERISCGVPPPLENGF-HSADDFYA 1708
            G+ +N  C PG+   G P    CL    WT     C R SC  PP   NG  H       
Sbjct: 66   GTYLNYECRPGYS--GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQF 123

Query: 1709 GSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSCLDVDECAVGSDCSEHASCLNVD 1765
            GS + Y C  GY L+G S   C  +G    W+  +P C   D    G             
Sbjct: 124  GSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPIC---DRIPCG------------- 167

Query: 1766 GSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEG------Y 1819
                   +PP   +G   +         N EN H        G+ VT+ C  G      +
Sbjct: 168  -------LPPTITNGDFIST--------NRENFH-------YGSVVTYRCNPGSGGRKVF 205

Query: 1820 QLMGVTKITCLES----GEWNHLIPYCKAVSCGKPAIPENGCI---EELAFTFGSKVTYR 1872
            +L+G   I C  +    G W+   P C   +   P   ENG +       F+    V +R
Sbjct: 206  ELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFR 265

Query: 1873 CNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTAS---Y 1929
            C  G+ + G +   C A + W    P C  V C  P ++ + +         S      Y
Sbjct: 266  CQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFY 324

Query: 1930 SCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGE--PPAIKDAVITGNNFTFRNTVTY 1987
            SC+ GY L+G + + CT  G W  A P C +  C +     +   V+   N      V +
Sbjct: 325  SCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDF 384

Query: 1988 TCKEGYTLAGLDTIECLADGK---WSRSDQQCLAVSCDEPPIVD---HASPETAHRLFGD 2041
             C EG+ L G     C+  G    W+ S   C  + C  PP++    H         FG 
Sbjct: 385  VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGK 444

Query: 2042 IAFYYCSD------GYSLADNSQLLCNAQ----GKWVPPEGQDMPRC-IAHFCEKPPSVS 2090
               Y C         + L   S + C +     G W  P     PRC I   C+ P    
Sbjct: 445  TVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPA----PRCGILGHCQAPDHFL 500

Query: 2091 YSILESVSKAK-FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEP 2149
            ++ L++ + A  F  G+ + ++C   +       I C+    W+ SP  + C    C  P
Sbjct: 501  FAKLKTQTNASDFPIGTSLKYECRPEYY-GRPFSITCLDNLVWS-SPKDV-CKRKSCKTP 557

Query: 2150 PSIMNGYASG-SNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQ---WSSPIPTCHPVSCG 2205
            P  +NG     ++   G+ + YSC  G  + G   + C  +G    WS+  P C  + CG
Sbjct: 558  PDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCG 617

Query: 2206 EPPKVENGFLEHTTGRIFE--SEVRYQCNPG------YKSVGSPVFVCQANRH----WHS 2253
             PP + NG    T    F   S V Y+CNPG      ++ VG P   C +N      W  
Sbjct: 618  LPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSG 677

Query: 2254 ESPLMCVPLDCGKPPPIQNGFMKGEN---FEVGSKVQFFCNEGYELVGDSSWTCQKSGKW 2310
             +P   +P  C  PP ++NG +  +N   F +   V+F C  G+ + G     CQ   KW
Sbjct: 678  PAPQCIIPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 736

Query: 2311 NKKSNPKCMPAKCPEPPLLENQLVL--KELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQ 2368
              +  P C     P P +L  +     K+  +    V +SC+ G+ L+G + ++C P   
Sbjct: 737  EPEL-PSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 795

Query: 2369 WNDSFPVCKIVLCTP--PPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDG 2426
            W+ + P C++  C      L++  V  P + L  G+ V + C  GF L+G+S + C   G
Sbjct: 796  WSPAAPTCEVKSCDDFMGQLLNGRVLFPVN-LQLGAKVDFVCDEGFQLKGSSASYCVLAG 854

Query: 2427 T---WSSPLPECVPVECPQPEEIPNGIIDVQGLAYL---STALYTCKP------GFELVG 2474
                W+S +P C  + CP P  IPNG    + L          YTC P       F+L+G
Sbjct: 855  MESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIG 914

Query: 2475 NTTTLCGE----NGHWLGGKPTCKAI-ECLKPKEILNGKF----SYTDLHYGQTVTYSCN 2525
             +T  C      NG W    P C  +  C  P   L  K     + +D   G ++ Y C 
Sbjct: 915  ESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECR 974

Query: 2526 RGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEG-ADYSYGAIIIYSCFP 2584
              +    P ++TCL+   W      C    C +P    NG V    D   G+ I YSC  
Sbjct: 975  PEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTT 1033

Query: 2585 GFQVAGHAMQTCEESG----WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDM 2640
            G ++ GH+   C  SG    WS+  P C  I CGLPP I  GD                 
Sbjct: 1034 GHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFI--------------- 1078

Query: 2641 MEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPG------YELLGN 2694
                                        +T+  NF YG++V+Y CN G      +EL+G 
Sbjct: 1079 ----------------------------STNRENFHYGSVVTYRCNLGSRGRKVFELVGE 1110

Query: 2695 PVLICQED----GTWNGSAPSCISIECDLPTAPENGFLRFTETSMGS---AVQYSCKPGH 2747
            P + C  +    G W+G AP CI      P   ENG L     S+ S    V++ C+PG 
Sbjct: 1111 PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF 1170

Query: 2748 ILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGS---NYTYLSTLYYECDPG 2804
            ++ G     C    KW    P C  + C+ P  +++G    S   N++    ++Y C+PG
Sbjct: 1171 VMKGPRRVKCQALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPG 1229

Query: 2805 YVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQ------KEIEYT 2858
            Y L G     C    +W  + P C    C        GQ+      F        ++ + 
Sbjct: 1230 YDLRGAASLHCTPQGDWSPEAPRCAVKSCDD----FLGQLPHGRVLFPLNLQLGAKVSFV 1285

Query: 2859 CNEGFLLEGARSRVCLANGS---WSGATPDCVPVRCATPPQLANGVTEGLDYG---FMKE 2912
            C+EGF L+G+    C+  G    W+ + P C  + C  PP + NG   G   G   + KE
Sbjct: 1286 CDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKE 1345

Query: 2913 VTFHCHEG------YILHGAPKLTCQSD----GNWDAEIPLC----KPVNCGPPEDLAHG 2958
            +++ C         + L G   + C SD    G W +  P C    +  +C  PE     
Sbjct: 1346 ISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFA 1405

Query: 2959 FP----NGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEY 3014
             P    N F F  G  + Y+C PGY      S  CL N  WS    +C    C  P   +
Sbjct: 1406 SPTIPINDFEFPVGTSLNYECRPGY-FGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPF 1464

Query: 3015 -GTVN-GTDFDCGKAARIQCFKGFKLLGLSEITCEADGQ---WSSGFPHCEHTSCGSLPM 3069
             G V+  TD   G      C +GF+L+G    TC   G    W    P CE  SC   P 
Sbjct: 1465 NGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPT 1524

Query: 3070 IPNAFI---SETSSWKENVITYSCRSG------YVIQGSSDLICTEK----GVWSQPYPV 3116
            I N      + TS     V+TY C +G      + + G   + CT K    GVWS P P 
Sbjct: 1525 ISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPR 1584

Query: 3117 CEPLSCGSPPSVANAV---ATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPER 3173
            C   +  + P V NA+         T    ++ RC  G+ M   + T  CQ +GRW P+ 
Sbjct: 1585 CISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVM-VGSHTVQCQTNGRWGPKL 1643

Query: 3174 ISCSPKKCPLPENI--THILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPF 3231
              CS    P PE +   H L H D+FS  ++V  SC   Y   G     C   G W P  
Sbjct: 1644 PHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSP-- 1701

Query: 3232 SDESCSPVSCGK--PESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQ---ENRQ 3286
                C+  SC     + P    ++       + + + C+ G+ L+G     C        
Sbjct: 1702 EAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKAL 1761

Query: 3287 WSGGVAICKETRCETPLEFLNGK---ADIENRTTGPNVVYSCN----RG--YSLEGPSEA 3337
            W+  V +C++  C  P   LNG+       +   G  + Y+C+    RG  ++L G S  
Sbjct: 1762 WNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSI 1821

Query: 3338 HCTE----NGTWSHPVPLCK---PNPCPVPFVIPENALLSEKE--FYVDQNVSIKCREGF 3388
             CT     NG WS P P C+   P  CP P  I     +      +     +S  C  G+
Sbjct: 1822 RCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGY 1881

Query: 3389 LLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVH----YQYGDMITYSCYS 3444
            LL G G I C     W+Q    C++++C  P  + N I++ +     Y YGD +T  C  
Sbjct: 1882 LLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFM-NGISKELEMKKVYHYGDYVTLKCED 1940

Query: 3445 GYMLEGFLRSVCLENGTWTSPPICRAVCR 3473
            GY LEG   S C  +  W  PP+ +   R
Sbjct: 1941 GYTLEGSPWSQCQADDRW-DPPLAKCTSR 1968



 Score =  590 bits (1521), Expect = e-168
 Identities = 517/1838 (28%), Positives = 744/1838 (40%), Gaps = 256/1838 (13%)

Query: 1859 EELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGK-YI 1917
            +E  F  G+ + Y C  GY+        CL NS W+ +   C    C +P +  NG  ++
Sbjct: 59   DEFEFPIGTYLNYECRPGYS-GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHV 117

Query: 1918 LSGLTYLSTASYSCDTGYSLQGPSIIECTASG---IWDRAPPACHLVFCGEPPAIK--DA 1972
            + G+ + S   YSC  GY L G S   C  SG   IWD   P C  + CG PP I   D 
Sbjct: 118  IKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDF 177

Query: 1973 VITGN-NFTFRNTVTYTCKEG------YTLAGLDTIECLAD----GKWSRSDQQCLAVSC 2021
            + T   NF + + VTY C  G      + L G  +I C ++    G WS    QC+  + 
Sbjct: 178  ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 237

Query: 2022 DEPPIVDHASPETAHR-LFG--DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRC 2078
              PP V++    + +R LF   ++  + C  G+ +    ++ C A  KW P    ++P C
Sbjct: 238  CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEP----ELPSC 293

Query: 2079 IAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMS 2138
             +  C+ PP V ++      K  F+ G  V + C  G+ L  +A + C   G W+P+  +
Sbjct: 294  -SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPT 352

Query: 2139 IQCIPVRCGE-PPSIMNGYASGS-NYSFGAMVAYSCNKGFYIKGEKKSTCEATGQ---WS 2193
              C    C +    ++NG      N   GA V + C++GF +KG   S C   G    W+
Sbjct: 353  --CEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN 410

Query: 2194 SPIPTCHPVSCGEPPKVENGFLEHTTGRI----FESEVRYQCNP------GYKSVGSPVF 2243
            S +P C  + C  PP + NG   HT   +    F   V Y C+P       +  +G    
Sbjct: 411  SSVPVCEQIFCPSPPVIPNG--RHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTI 468

Query: 2244 VC----QANRHWHSESPLMCVPLDCGKPPPIQNGFMKGE----NFEVGSKVQFFCNEGYE 2295
             C    Q N  W S +P   +   C  P       +K +    +F +G+ +++ C   Y 
Sbjct: 469  RCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY- 527

Query: 2296 LVGDSSWTCQKSGKWNKKSNPK--CMPAKCPEPPLLENQLVLKELTTEVGV-VTFSCKEG 2352
                 S TC  +  W   S+PK  C    C  PP   N +V      +VG  + +SC  G
Sbjct: 528  YGRPFSITCLDNLVW---SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTG 584

Query: 2353 HVLQGPSVLKCLPS---QQWNDSFPVCKIVLCTPPPLISFGVPIPSSA--LHFGSTVKYS 2407
            H L G S  +C+ S     W+   P+C+ + C  PP I+ G  I ++    H+GS V Y 
Sbjct: 585  HRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYR 644

Query: 2408 CVGG------FFLRGNSTTLCQPD----GTWSSPLPECV-PVECPQPEEIPNGII--DVQ 2454
            C  G      F L G  +  C  +    G WS P P+C+ P +C  P  + NGI+  D +
Sbjct: 645  CNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN-VENGILVSDNR 703

Query: 2455 GLAYLSTAL-YTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTD 2513
             L  L+  + + C+PGF + G     C     W    P+C  + C  P ++L+ + +  D
Sbjct: 704  SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRD 762

Query: 2514 ---LHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDS--PQPIENGFVE 2568
                  GQ V YSC  G+ L G +++ C   GDW   AP+C    CD    Q +    + 
Sbjct: 763  KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLF 822

Query: 2569 GADYSYGAIIIYSCFPGFQVAGHAMQTC----EESGWSSSIPTCMPIDCGLP-------- 2616
              +   GA + + C  GFQ+ G +   C     ES W+SS+P C  I C  P        
Sbjct: 823  PVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRH 882

Query: 2617 -------------------PHIDFGD-----------CTKLKDDQGYFEQEDDMMEVPYV 2646
                               PH D G            CT      G +        +   
Sbjct: 883  TGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGH 942

Query: 2647 TPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLI-CQEDGTW 2705
               P + L A  KT         T++S+F  GT + Y C P Y   G P  I C ++  W
Sbjct: 943  CQAPDHFLFAKLKT--------QTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVW 992

Query: 2706 NGSAPSCISIECDLPTAPENGFLR-FTETSMGSAVQYSCKPGHILAGSDLRLCL---ENR 2761
            +     C    C  P  P NG +   T+  +GS + YSC  GH L G     C+      
Sbjct: 993  SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTA 1052

Query: 2762 KWSGASPRCEAISCKKPNPVMNG---SIKGSNYTYLSTLYYECDPG------YVLNGTER 2812
             WS   P C+ I C  P  + NG   S    N+ Y S + Y C+ G      + L G   
Sbjct: 1053 HWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPS 1112

Query: 2813 RTCQDDKN----WDEDEPICIPVDCSSPPVSANGQVRGDE---YTFQKEIEYTCNEGFLL 2865
              C  + +    W    P CI  +  +PP   NG +  D    ++  + +E+ C  GF++
Sbjct: 1113 IYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVM 1172

Query: 2866 EGARSRVCLANGSWSGATPDCVPVRCATPPQLANG---VTEGLDYGFMKEVTFHCHEGYI 2922
            +G R   C A   W    P C  V C  PP++ +G    +   ++   +EV + C  GY 
Sbjct: 1173 KGPRRVKCQALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYD 1231

Query: 2923 LHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNG-----FSFIHGGHIQYQCFP 2977
            L GA  L C   G+W  E P C   +C   +D     P+G      +   G  + + C  
Sbjct: 1232 LRGAASLHCTPQGDWSPEAPRCAVKSC---DDFLGQLPHGRVLFPLNLQLGAKVSFVCDE 1288

Query: 2978 GYKLHGNSSRRCLSNGS---WSGSSPSCLPCRC-STPVIEYGTVNGT---DFDCGKAARI 3030
            G++L G+S   C+  G    W+ S P C    C + P I  G   GT   D   GK    
Sbjct: 1289 GFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISY 1348

Query: 3031 QC------FKGFKLLGLSEITCEAD----GQWSSGFPHCEHTSCGSLPMIPNAF------ 3074
             C         F L+G S I C +D    G WSS  P CE +        P  F      
Sbjct: 1349 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPT 1408

Query: 3075 --ISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAV 3132
              I++        + Y CR GY  +  S + C E  VWS     C   SCG PP   N +
Sbjct: 1409 IPINDFEFPVGTSLNYECRPGYFGKMFS-ISCLENLVWSSVEDNCRRKSCGPPPEPFNGM 1467

Query: 3133 ATGEAHT-YESEVKLRCLEGYTMDTDTDTFTCQKDGR---WFPERISCSPKKCPLPENIT 3188
                  T + S V   C EG+ +     T TC   G    W  +   C    C  P  I+
Sbjct: 1468 VHINTDTQFGSTVNYSCNEGFRLIGSPST-TCLVSGNNVTWDKKAPICEIISCEPPPTIS 1526

Query: 3189 HILVHGDDFSVNRQ-------VSVSCAEG------YTFEGVNISVCQLD----GTWEPPF 3231
                +GD +S NR        V+  C  G      +   G     C       G W  P 
Sbjct: 1527 ----NGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSP- 1581

Query: 3232 SDESCSPVSCGKPESPEHGFVVGSKYTFEST--IIYQCEPGYELEGNRERVCQENRQWSG 3289
                 S   C  PE      V G++  F  T  I ++C+PG+ + G+    CQ N +W  
Sbjct: 1582 PPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGP 1641

Query: 3290 GVAICKETRCETPLEFLNGKADI---ENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWS 3346
             +  C    C+ P E L+G+  +   +N + G  V YSC   Y L G +  HCT  G WS
Sbjct: 1642 KLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWS 1700

Query: 3347 HPVPLCKPNPCPVPFV--IPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC---NPD 3401
               P C    C   F+  +P   +L      +   VS  C EGF L+G     C      
Sbjct: 1701 PEAPRCTVKSCD-DFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMK 1759

Query: 3402 ETWTQTSAKCEKISCGPPAHVENAIARGVHY---QYGDMITYSCYS------GYMLEGFL 3452
              W  +   CE+I C  P  + N    G  +    YG  I+Y+C +       + L G  
Sbjct: 1760 ALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGES 1819

Query: 3453 RSVCLE----NGTWTSP-PICR----AVCRFP--CQNG 3479
               C      NG W+SP P C     A C  P   QNG
Sbjct: 1820 SIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNG 1857



 Score =  541 bits (1393), Expect = e-153
 Identities = 467/1718 (27%), Positives = 689/1718 (40%), Gaps = 247/1718 (14%)

Query: 1646 EDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCG--VPPPLENGFHSA 1703
            ++  PG +V   C+PG+ L G     C  QG W+   P CE  SC   +   L       
Sbjct: 314  DNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 373

Query: 1704 DDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSCLDVDEC----------- 1749
             +   G+ V + C+ G+ L G S  +C   G    WN   P C  +  C           
Sbjct: 374  VNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQI-FCPSPPVIPNGRH 432

Query: 1750 ------------AVGSDCSEH---ASCLNVDGSYICSCVPPYTGDG------KNCAEPIK 1788
                         V   C  H    +  ++ G     C     G+G        C     
Sbjct: 433  TGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGH 492

Query: 1789 CKAPGN----PENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKA 1844
            C+AP +         ++   + +G  + + C+  Y     + ITCL++  W+     CK 
Sbjct: 493  CQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKR 551

Query: 1845 VSCGKPAIPENGCIEELA-FTFGSKVTYRCNKGYTLAGDKESSCLANSS---WSHSPPVC 1900
             SC  P  P NG +  +     GS++ Y C  G+ L G   + C+ + +   WS  PP+C
Sbjct: 552  KSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPIC 611

Query: 1901 EPVKCSSPENINNGKYILS---GLTYLSTASYSCDTG------YSLQGPSIIECTAS--- 1948
            + + C  P  I NG +I +      Y S  +Y C+ G      + L G   I CT++   
Sbjct: 612  QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671

Query: 1949 -GIWDRAPPACHLVFCGEPPAIKDAVITGNN---FTFRNTVTYTCKEGYTLAGLDTIECL 2004
             GIW    P C +     PP +++ ++  +N   F+    V + C+ G+ + G   ++C 
Sbjct: 672  VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 731

Query: 2005 ADGKWSRSDQQCLAVSCDEPPIVDHASPETAHR---LFGDIAFYYCSDGYSLADNSQLLC 2061
            A  KW      C  V C  PP V HA      +     G   FY C  GY L   + + C
Sbjct: 732  ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC 790

Query: 2062 NAQGKWVPPEGQDMPRCIAHFCE--KPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLN 2119
              QG W P      P C    C+      ++  +L  V+      G+ V F C EGF L 
Sbjct: 791  TPQGDWSPA----APTCEVKSCDDFMGQLLNGRVLFPVN---LQLGAKVDFVCDEGFQLK 843

Query: 2120 TSAKIECMRGGQ---WNPS-PMSIQCIPVRCGEPPSIMNGYASGSN---YSFGAMVAYSC 2172
             S+   C+  G    WN S P+   C  + C  PP I NG  +G     + FG  V Y+C
Sbjct: 844  GSSASYCVLAGMESLWNSSVPV---CEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTC 900

Query: 2173 N------KGFYIKGEKKSTC----EATGQWSSPIPTCHPVS-CGEPPKVENGFLEHTTGR 2221
            +        F + GE    C    +  G WSSP P C  +  C  P       L+  T  
Sbjct: 901  DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNA 960

Query: 2222 I---FESEVRYQCNPGYKSVGSPVFV-CQANRHWHSESPLMCVPLDCGKPPPIQNGFMKG 2277
                  + ++Y+C P Y   G P  + C  N  W S    +C    C  PP   NG +  
Sbjct: 961  SDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKD-VCKRKSCKTPPDPVNGMVHV 1017

Query: 2278 -ENFEVGSKVQFFCNEGYELVGDSSWTCQKSGK---WNKKSNPKCMPAKCPEPPLLENQL 2333
              + +VGS++ + C  G+ L+G SS  C  SG    W+ K  P C    C  PP + N  
Sbjct: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKP-PICQRIPCGLPPTIANGD 1076

Query: 2334 VL---KELTTEVGVVTFSCKEG------HVLQGPSVLKCLPSQQ----WNDSFPVCKIVL 2380
             +   +E      VVT+ C  G        L G   + C  +      W+   P C I  
Sbjct: 1077 FISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN 1136

Query: 2381 CTPPPLISFGVPIPS--SALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPV 2438
               PP +  G+ +    S       V++ C  GF ++G     CQ    W   LP C  V
Sbjct: 1137 KCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1196

Query: 2439 ECPQPEEIPNGIIDVQGLAYLS---TALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKA 2495
             C  P EI +G          S      Y+C+PG++L G  +  C   G W    P C  
Sbjct: 1197 -CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAV 1255

Query: 2496 IECLK-PKEILNGKFSY-TDLHYGQTVTYSCNRGFRLEGPSALTCLETGD---WDVDAPS 2550
              C     ++ +G+  +  +L  G  V++ C+ GFRL+G S   C+  G    W+   P 
Sbjct: 1256 KSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPV 1315

Query: 2551 CNAIHCDSPQPIENGFVEG---ADYSYGAIIIYSCFP------GFQVAGHAMQTCEESG- 2600
            C  I C +P  I NG   G    D  YG  I Y+C P       F + G +   C     
Sbjct: 1316 CEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPH 1375

Query: 2601 ----WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGA 2656
                WSS  P C                 +L    G+ +  +   + P+ +P  P     
Sbjct: 1376 GNGVWSSPAPRC-----------------ELSVRAGHCKTPE---QFPFASPTIP----- 1410

Query: 2657 VAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLI-CQEDGTWNGSAPSCISI 2715
                          +   F  GT ++Y C PGY   G    I C E+  W+    +C   
Sbjct: 1411 -------------INDFEFPVGTSLNYECRPGY--FGKMFSISCLENLVWSSVEDNCRRK 1455

Query: 2716 ECDLPTAPENGFLRF-TETSMGSAVQYSCKPGHILAGSDLRLCL---ENRKWSGASPRCE 2771
             C  P  P NG +   T+T  GS V YSC  G  L GS    CL    N  W   +P CE
Sbjct: 1456 SCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE 1515

Query: 2772 AISCKKPNPVMNGSIKGSNYTYL---STLYYECDPG------YVLNGTERRTC--QDDK- 2819
             ISC+ P  + NG    +N T     + + Y+C  G      + L G     C  +DD+ 
Sbjct: 1516 IISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQV 1575

Query: 2820 -NWDEDEPICIPVD-CSSPPVSANGQVRGDE--YTFQKEIEYTCNEGFLLEGARSRVCLA 2875
              W    P CI  + C++P V    +V G+   +T  + I + C  GF++ G+ +  C  
Sbjct: 1576 GVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQT 1635

Query: 2876 NGSWSGATPDCVPVRCATPPQLANG---VTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQ 2932
            NG W    P C  V C  PP++ +G   ++   ++   +EV + C   Y L GA  L C 
Sbjct: 1636 NGRWGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCT 1694

Query: 2933 SDGNWDAEIPLCKPVNCGPPEDLAHGFPNG-----FSFIHGGHIQYQCFPGYKLHGNSSR 2987
              G+W  E P C   +C   +D     P+G      +   G  + + C  G++L G S+ 
Sbjct: 1695 PQGDWSPEAPRCTVKSC---DDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSAS 1751

Query: 2988 RCLSNGS---WSGSSPSCLPCRC-STPVIEYGTVNGT---DFDCGKAARIQC------FK 3034
             C+  G    W+ S P C    C + P I  G   GT   D   GK     C        
Sbjct: 1752 HCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGM 1811

Query: 3035 GFKLLGLSEITCEAD----GQWSSGFPHCE---HTSCGSLPMIPNAFI--SETSSWKENV 3085
             F L+G S I C +D    G WSS  P CE     +C   P I N        S +   +
Sbjct: 1812 TFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGM 1871

Query: 3086 -ITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSP---PSVANAVATGEAHTYE 3141
             I+Y C  GY++ G   + CT++G+WSQ    C+ ++C  P     ++  +   + + Y 
Sbjct: 1872 TISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYG 1931

Query: 3142 SEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPK 3179
              V L+C +GYT++  +    CQ D RW P    C+ +
Sbjct: 1932 DYVTLKCEDGYTLE-GSPWSQCQADDRWDPPLAKCTSR 1968



 Score =  417 bits (1071), Expect = e-115
 Identities = 378/1379 (27%), Positives = 544/1379 (39%), Gaps = 215/1379 (15%)

Query: 2280 FEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELT 2339
            F +G+ + + C  GY      S  C K+  W    + +C    C  PP   N +V     
Sbjct: 63   FPIGTYLNYECRPGYS-GRPFSIICLKNSVWTGAKD-RCRRKSCRNPPDPVNGMVHVIKG 120

Query: 2340 TEVGV-VTFSCKEGHVLQGPSVLKCLPSQQ---WNDSFPVCKIVLCTPPPLISFGVPIPS 2395
             + G  + +SC +G+ L G S   C+ S     W++  P+C  + C  PP I+ G  I +
Sbjct: 121  IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST 180

Query: 2396 SA--LHFGSTVKYSCVGG------FFLRGNSTTLCQPD----GTWSSPLPECV-PVECPQ 2442
            +    H+GS V Y C  G      F L G  +  C  +    G WS P P+C+ P +C  
Sbjct: 181  NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240

Query: 2443 PEEIPNGII--DVQGLAYLSTAL-YTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECL 2499
            P  + NGI+  D + L  L+  + + C+PGF + G     C     W    P+C  + C 
Sbjct: 241  PN-VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQ 298

Query: 2500 KPKEILNGKFSYTD---LHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHC 2556
             P ++L+ + +  D      GQ V YSC  G+ L G +++ C   GDW   AP+C    C
Sbjct: 299  PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSC 358

Query: 2557 DS--PQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCE----ESGWSSSIPTCMP 2610
            D    Q +    +   +   GA + + C  GFQ+ G +   C     ES W+SS+P C  
Sbjct: 359  DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQ 418

Query: 2611 IDCGLPP---------------------------HIDFGD-----------CTKLKDDQG 2632
            I C  PP                           H D G            CT      G
Sbjct: 419  IFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNG 478

Query: 2633 YFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELL 2692
             +        +      P + L A  KT         T++S+F  GT + Y C P Y   
Sbjct: 479  VWSSPAPRCGILGHCQAPDHFLFAKLKT--------QTNASDFPIGTSLKYECRPEY--Y 528

Query: 2693 GNPVLI-CQEDGTWNGSAPSCISIECDLPTAPENGFLR-FTETSMGSAVQYSCKPGHILA 2750
            G P  I C ++  W+     C    C  P  P NG +   T+  +GS + YSC  GH L 
Sbjct: 529  GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLI 588

Query: 2751 GSDLRLCLENRK---WSGASPRCEAISCKKPNPVMNG---SIKGSNYTYLSTLYYECDPG 2804
            G     C+ +     WS   P C+ I C  P  + NG   S    N+ Y S + Y C+PG
Sbjct: 589  GHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPG 648

Query: 2805 ------YVLNGTERRTCQDDKN----WDEDEPICIPVDCSSPPVSANGQVRGDE---YTF 2851
                  + L G     C  + +    W    P CI  +  +PP   NG +  D    ++ 
Sbjct: 649  SGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSL 708

Query: 2852 QKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLD---YG 2908
             + +E+ C  GF+++G R   C A   W    P C  V C  PP + +      D   + 
Sbjct: 709  NEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFS 767

Query: 2909 FMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNG-----F 2963
              +EV + C  GY L GA  + C   G+W    P C+  +C   +D      NG      
Sbjct: 768  PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSC---DDFMGQLLNGRVLFPV 824

Query: 2964 SFIHGGHIQYQCFPGYKLHGNSSRRCLSNGS---WSGSSPSCLPCRC-STPVIEYGTVNG 3019
            +   G  + + C  G++L G+S+  C+  G    W+ S P C    C S PVI  G   G
Sbjct: 825  NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 884

Query: 3020 TD---FDCGKAARIQCFK------GFKLLGLSEITCEAD----GQWSSGFPHC------- 3059
                 F  GKA    C         F L+G S I C +D    G WSS  P C       
Sbjct: 885  KPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQ 944

Query: 3060 --EHTSCGSLPMIPNA--FISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYP 3115
              +H     L    NA  F   TS      + Y CR  Y  +  S + C +  VWS P  
Sbjct: 945  APDHFLFAKLKTQTNASDFPIGTS------LKYECRPEYYGRPFS-ITCLDNLVWSSPKD 997

Query: 3116 VCEPLSCGSPPSVANAVATGEAHTYE-----SEVKLRCLEGYTM--DTDTDTFTCQKDGR 3168
            VC+  SC +PP   N    G  H        S +   C  G+ +   +  +         
Sbjct: 998  VCKRKSCKTPPDPVN----GMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAH 1053

Query: 3169 WFPERISCSPKKCPLPENITHILVHGDDFSVNRQ-------VSVSCAEG------YTFEG 3215
            W  +   C    C LP  I +    GD  S NR+       V+  C  G      +   G
Sbjct: 1054 WSTKPPICQRIPCGLPPTIAN----GDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVG 1109

Query: 3216 VNISVCQLD----GTWEPPFSDESCSPVSCGKPESPEHGFVVG---SKYTFESTIIYQCE 3268
                 C  +    G W  P + +   P  C  P + E+G +V    S ++    + ++C+
Sbjct: 1110 EPSIYCTSNDDQVGIWSGP-APQCIIPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQ 1167

Query: 3269 PGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGK---ADIENRTTGPNVVYSC 3325
            PG+ ++G R   CQ   +W   +  C    C+ P E L+G+   +  +N + G  V YSC
Sbjct: 1168 PGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSC 1226

Query: 3326 NRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFV--IPENALLSEKEFYVDQNVSIK 3383
              GY L G +  HCT  G WS   P C    C   F+  +P   +L      +   VS  
Sbjct: 1227 EPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCD-DFLGQLPHGRVLFPLNLQLGAKVSFV 1285

Query: 3384 CREGFLLQGHGIITC---NPDETWTQTSAKCEKISCGPPAHVENAIARGV---HYQYGDM 3437
            C EGF L+G  +  C        W  +   CE I C  P  + N    G       YG  
Sbjct: 1286 CDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKE 1345

Query: 3438 ITYSC------YSGYMLEGFLRSVCLE----NGTWTSP-PICRAVCRFPCQNGGICQRP 3485
            I+Y+C         + L G     C      NG W+SP P C    R      G C+ P
Sbjct: 1346 ISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVR-----AGHCKTP 1399



 Score =  295 bits (756), Expect = 4e-79
 Identities = 230/833 (27%), Positives = 342/833 (41%), Gaps = 92/833 (11%)

Query: 2719 LPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKP 2778
            LP A         E  +G+ + Y C+PG+      + +CL+N  W+GA  RC   SC+ P
Sbjct: 49   LPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTGAKDRCRRKSCRNP 107

Query: 2779 NPVMNGS---IKGSNYTYLSTLYYECDPGYVLNGTERRTC---QDDKNWDEDEPICIPVD 2832
               +NG    IKG  +   S + Y C  GY L G+   TC    D   WD + PIC  + 
Sbjct: 108  PDPVNGMVHVIKGIQFG--SQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIP 165

Query: 2833 CSSPPVSANG---QVRGDEYTFQKEIEYTCNEG------FLLEGARSRVCLAN----GSW 2879
            C  PP   NG       + + +   + Y CN G      F L G  S  C +N    G W
Sbjct: 166  CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225

Query: 2880 SGATPDCVPVRCATPPQLANGVTEGLD---YGFMKEVTFHCHEGYILHGAPKLTCQSDGN 2936
            SG  P C+     TPP + NG+    +   +   + V F C  G+++ G  ++ CQ+   
Sbjct: 226  SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 285

Query: 2937 WDAEIPLCKPVNCGPPEDLAHG---FPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNG 2993
            W+ E+P C  V C PP D+ H      +  +F  G  + Y C PGY L G +S RC   G
Sbjct: 286  WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQG 344

Query: 2994 SWSGSSPSCLPCRCST---PVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADG 3050
             WS ++P+C    C      ++    +   +   G      C +GF+L G S   C   G
Sbjct: 345  DWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAG 404

Query: 3051 Q---WSSGFPHCEHTSCGSLPMIPNAFISETSSWKE-----NVITYSC------RSGYVI 3096
                W+S  P CE   C S P+IPN     T    E       + Y+C       + + +
Sbjct: 405  MESLWNSSVPVCEQIFCPSPPVIPNG--RHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDL 462

Query: 3097 QGSSDLICTE----KGVWSQPYPVCEPLS-CGSPPSVANAVATGEAHTYE----SEVKLR 3147
             G S + CT      GVWS P P C  L  C +P     A    + +  +    + +K  
Sbjct: 463  IGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYE 522

Query: 3148 CLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHG-DDFSVNRQVSVS 3206
            C   Y       + TC  +  W   +  C  K C  P +  + +VH   D  V  +++ S
Sbjct: 523  CRPEYY--GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYS 580

Query: 3207 CAEGYTFEGVNISVCQLDGT---W--EPPFSDESCSPVSCGKPESPEHGFVVGS---KYT 3258
            C  G+   G + + C L G    W  +PP     C  + CG P +  +G  + +    + 
Sbjct: 581  CTTGHRLIGHSSAECILSGNAAHWSTKPPI----CQRIPCGLPPTIANGDFISTNRENFH 636

Query: 3259 FESTIIYQCEPG------YELEGNRERVCQENRQ----WSGGVAICKETRCETPLEFLNG 3308
            + S + Y+C PG      +EL G     C  N      WSG    C      TP    NG
Sbjct: 637  YGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENG 696

Query: 3309 KADIENR---TTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPE 3365
                +NR   +    V + C  G+ ++GP    C     W   +P C     P P V+  
Sbjct: 697  ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHA 756

Query: 3366 NALLSEKE-FYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGP--PAHV 3422
                 +K+ F   Q V   C  G+ L+G   + C P   W+  +  CE  SC       +
Sbjct: 757  ERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLL 816

Query: 3423 ENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENG---TW-TSPPICRAV 3471
               +   V+ Q G  + + C  G+ L+G   S C+  G    W +S P+C  +
Sbjct: 817  NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQI 869



 Score =  282 bits (721), Expect = 5e-75
 Identities = 249/923 (26%), Positives = 363/923 (39%), Gaps = 139/923 (15%)

Query: 2670 THSSNFLYGTMVSYTCNPGYELLGNPV-LICQEDGTWNGSAPSCISIECDLPTAPENGFL 2728
            T    F  GT ++Y C PGY   G P  +IC ++  W G+   C    C  P  P NG +
Sbjct: 58   TDEFEFPIGTYLNYECRPGYS--GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMV 115

Query: 2729 RFTE-TSMGSAVQYSCKPGHILAGSDLRLCL---ENRKWSGASPRCEAISCKKPNPVMNG 2784
               +    GS ++YSC  G+ L GS    C+   +   W   +P C+ I C  P  + NG
Sbjct: 116  HVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNG 175

Query: 2785 ---SIKGSNYTYLSTLYYECDPG------YVLNGTERRTCQDDKN----WDEDEPICIPV 2831
               S    N+ Y S + Y C+PG      + L G     C  + +    W    P CI  
Sbjct: 176  DFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 235

Query: 2832 DCSSPPVSANGQVRGDE---YTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVP 2888
            +  +PP   NG +  D    ++  + +E+ C  GF+++G R   C A   W    P C  
Sbjct: 236  NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR 295

Query: 2889 VRCATPPQLANGVTEGLD---YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCK 2945
            V C  PP + +      D   +   +EV + C  GY L GA  + C   G+W    P C+
Sbjct: 296  V-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE 354

Query: 2946 PVNCGPPEDLAHGFPNG-----FSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGS---WSG 2997
              +C   +D      NG      +   G  + + C  G++L G+S+  C+  G    W+ 
Sbjct: 355  VKSC---DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 411

Query: 2998 SSPSCLPCRC-STPVIEYGTVNGTD---FDCGKAARIQC------FKGFKLLGLSEITCE 3047
            S P C    C S PVI  G   G     F  GK     C         F L+G S I C 
Sbjct: 412  SVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCT 471

Query: 3048 AD----GQWSSGFPHC---------EHTSCGSLPMIPNA--FISETSSWKENVITYSCRS 3092
            +D    G WSS  P C         +H     L    NA  F   TS      + Y CR 
Sbjct: 472  SDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTS------LKYECRP 525

Query: 3093 GYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYE-----SEVKLR 3147
             Y  +  S + C +  VWS P  VC+  SC +PP   N    G  H        S +   
Sbjct: 526  EYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKTPPDPVN----GMVHVITDIQVGSRINYS 580

Query: 3148 CLEGYTM--DTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQ--- 3202
            C  G+ +   +  +         W  +   C    C LP  I     +GD  S NR+   
Sbjct: 581  CTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTI----ANGDFISTNRENFH 636

Query: 3203 ----VSVSCAEG------YTFEGVNISVCQLD----GTWEPPFSDESCSPVSCGKPESPE 3248
                V+  C  G      +   G     C  +    G W  P + +   P  C  P + E
Sbjct: 637  YGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP-APQCIIPNKC-TPPNVE 694

Query: 3249 HGFVVG---SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEF 3305
            +G +V    S ++    + ++C+PG+ ++G R   CQ   +W   +  C    C+ P + 
Sbjct: 695  NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDV 753

Query: 3306 LNG---KADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFV 3362
            L+    + D +N + G  V YSC  GY L G +   CT  G WS   P C+   C   F+
Sbjct: 754  LHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCD-DFM 812

Query: 3363 --IPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC---NPDETWTQTSAKCEKISCG 3417
              +    +L      +   V   C EGF L+G     C     +  W  +   CE+I C 
Sbjct: 813  GQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCP 872

Query: 3418 PPAHVENAIARGVH---YQYGDMITYSC------YSGYMLEGFLRSVCLE----NGTWTS 3464
             P  + N    G     + +G  + Y+C       + + L G     C      NG W+S
Sbjct: 873  SPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS 932

Query: 3465 P-PICRAVCRFPCQNGGICQRPN 3486
            P P C  +        G CQ P+
Sbjct: 933  PAPRCGIL--------GHCQAPD 947



 Score =  266 bits (679), Expect = 4e-70
 Identities = 210/773 (27%), Positives = 314/773 (40%), Gaps = 122/773 (15%)

Query: 1640 HLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISC----GVPPP 1695
            H  +  ++  PG +V   C+PG+ L G    +C  QG W+   P C   SC    G  P 
Sbjct: 1208 HTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPH 1267

Query: 1696 LENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSCLDV------ 1746
                F    +   G+ V++ C+ G+ L G S   C   G    WN   P C  +      
Sbjct: 1268 GRVLFPL--NLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPP 1325

Query: 1747 ------------DECAVGSDCS-------EHASCLNVDGSYICSCVPPYTGDG------K 1781
                         +   G + S       +     N+ G     C     G+G       
Sbjct: 1326 AILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAP 1385

Query: 1782 NCAEPIK---CKAP-----GNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESG 1833
             C   ++   CK P      +P    +  E + VG  + + C+ GY    +  I+CLE+ 
Sbjct: 1386 RCELSVRAGHCKTPEQFPFASPTIPINDFE-FPVGTSLNYECRPGY-FGKMFSISCLENL 1443

Query: 1834 EWNHLIPYCKAVSCGKPAIPENGCIEELAFT-FGSKVTYRCNKGYTLAGDKESSCLA--- 1889
             W+ +   C+  SCG P  P NG +     T FGS V Y CN+G+ L G   ++CL    
Sbjct: 1444 VWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGN 1503

Query: 1890 NSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYL---STASYSCDTG------YSLQGP 1940
            N +W    P+CE + C  P  I+NG +  +  T     +  +Y C TG      + L G 
Sbjct: 1504 NVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGE 1563

Query: 1941 SIIECTAS----GIWDRAPPACHLVFCGEPPAIKDAV-ITGNN--FTFRNTVTYTCKEGY 1993
              I CT+     G+W   PP C        P +++A+ + GN   FT    + + C+ G+
Sbjct: 1564 RSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGF 1623

Query: 1994 TLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHR---LFGDIAFYYCSDG 2050
             + G  T++C  +G+W      C  V C  PP + H     +H+     G   FY C   
Sbjct: 1624 VMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPS 1682

Query: 2051 YSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAK------FAA 2104
            Y L   + L C  QG W P    + PRC    C+         L  +   +         
Sbjct: 1683 YDLRGAASLHCTPQGDWSP----EAPRCTVKSCD-------DFLGQLPHGRVLLPLNLQL 1731

Query: 2105 GSVVSFKCMEGFVLNTSAKIECMRGGQ---WNPS-PMSIQCIPVRCGEPPSIMNGYASGS 2160
            G+ VSF C EGF L   +   C+  G    WN S P+   C  + C  PP+I+NG  +G+
Sbjct: 1732 GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPV---CEQIFCPNPPAILNGRHTGT 1788

Query: 2161 NYS---FGAMVAYSCN------KGFYIKGEKKSTC----EATGQWSSPIPTCH---PVSC 2204
             +    +G  ++Y+C+        F + GE    C    +  G WSSP P C    P +C
Sbjct: 1789 PFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAAC 1848

Query: 2205 GEPPKVENGFL--EHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPL 2262
              PPK++NG     H +  +    + Y C+PGY  VG     C     W S+    C  +
Sbjct: 1849 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIW-SQLDHYCKEV 1907

Query: 2263 DCGKPPPIQNGFMK----GENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWN 2311
            +C   P   NG  K     + +  G  V   C +GY L G     CQ   +W+
Sbjct: 1908 NCSF-PLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWD 1959



 Score =  159 bits (401), Expect = 6e-38
 Identities = 118/393 (30%), Positives = 164/393 (41%), Gaps = 68/393 (17%)

Query: 1658 CDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSA---DDFYAGSTVTY 1714
            C PGF +VG+    C   G+W   LPHC R+ C  PP + +G H+    D+F  G  V Y
Sbjct: 1619 CQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFY 1677

Query: 1715 QCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVP 1774
             C   Y L G + + CT  G W+  +P C  V  C        H   L            
Sbjct: 1678 SCEPSYDLRGAASLHCTPQGDWSPEAPRCT-VKSCDDFLGQLPHGRVL------------ 1724

Query: 1775 PYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGE 1834
                             P N +          +GA+V+F C EG++L G +   C+ +G 
Sbjct: 1725 ----------------LPLNLQ----------LGAKVSFVCDEGFRLKGRSASHCVLAGM 1758

Query: 1835 ---WNHLIPYCKAVSCGKPAIPENGCIEELAF---TFGSKVTYRCN----KGYT--LAGD 1882
               WN  +P C+ + C  P    NG      F    +G +++Y C+    +G T  L G+
Sbjct: 1759 KALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGE 1818

Query: 1883 KESSCLA----NSSWSHSPPVCE---PVKCSSPENINNGKYILSGLT-YLS--TASYSCD 1932
                C +    N  WS   P CE   P  C  P  I NG YI   ++ YL   T SY CD
Sbjct: 1819 SSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICD 1878

Query: 1933 TGYSLQGPSIIECTASGIWDRAPPACHLVFCGEP---PAIKDAVITGNNFTFRNTVTYTC 1989
             GY L G   I CT  GIW +    C  V C  P     I   +     + + + VT  C
Sbjct: 1879 PGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKC 1938

Query: 1990 KEGYTLAGLDTIECLADGKWSRSDQQCLAVSCD 2022
            ++GYTL G    +C AD +W     +C + + D
Sbjct: 1939 EDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHD 1971



 Score = 68.9 bits (167), Expect = 8e-11
 Identities = 48/167 (28%), Positives = 68/167 (40%), Gaps = 15/167 (8%)

Query: 405  RCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYK-TTCL 463
            RC PGF +VGS  + C  NG W     +C  R C    +  HG  + S ++         
Sbjct: 1618 RCQPGFVMVGSHTVQCQTNGRWGPKLPHCS-RVCQPPPEILHGEHTLSHQDNFSPGQEVF 1676

Query: 464  VACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTF--QMPKDVIISPHNCGKQPAKF 521
             +C+  Y L G+  L C     W    PRC  + C  F  Q+P   ++ P N      + 
Sbjct: 1677 YSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLN-----LQL 1731

Query: 522  GTICYVSCRQGFILSGVKEMLRCTTSGK---WNVGVQAAVCKDVEAP 565
            G      C +GF L G +    C  +G    WN  V   VC+ +  P
Sbjct: 1732 GAKVSFVCDEGFRLKG-RSASHCVLAGMKALWNSSV--PVCEQIFCP 1775



 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 63/225 (28%), Positives = 90/225 (40%), Gaps = 43/225 (19%)

Query: 362 CREGYRASGQT-------------------CELVHCPALKPPENGYFIQ-NTCNNHFNAA 401
           C +GYR  G +                   C+ + C       NG FI  N  N H+ + 
Sbjct: 131 CTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSV 190

Query: 402 CGVRCHPG------FDLVGSSIILCLPN----GLWSGSESYCRVRTCPHLRQPKH--GHI 449
              RC+PG      F+LVG   I C  N    G+WSG    C +   P+   P +    I
Sbjct: 191 VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII---PNKCTPPNVENGI 247

Query: 450 SCSTREMLYKTTCLVA--CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDV 507
             S    L+    +V   C  G+ ++G  ++ CQ  ++W+   P C  R C   Q P DV
Sbjct: 248 LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-SRVC---QPPPDV 303

Query: 508 IISPH-NCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
           + +      K     G   + SC  G+ L G   M RCT  G W+
Sbjct: 304 LHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM-RCTPQGDWS 347



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 58/195 (29%), Positives = 83/195 (42%), Gaps = 24/195 (12%)

Query: 373 CELVHCPALKPPENGYFIQ-NTCNNHFNAACGVRCHPG------FDLVGSSIILCLPN-- 423
           C+ + C       NG FI  N  N H+ +    RC+PG      F+LVG   I C  N  
Sbjct: 611 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 670

Query: 424 --GLWSGSESYCRVRTCPHLRQPKH--GHISCSTREMLYKTTCLVA--CDEGYRLEGSDK 477
             G+WSG    C +   P+   P +    I  S    L+    +V   C  G+ ++G  +
Sbjct: 671 QVGIWSGPAPQCII---PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 727

Query: 478 LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKFGTICYVSCRQGFILS 536
           + CQ  ++W+   P C  R C   Q P DV+ +      K     G   + SC  G+ L 
Sbjct: 728 VKCQALNKWEPELPSC-SRVC---QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 783

Query: 537 GVKEMLRCTTSGKWN 551
           G   M RCT  G W+
Sbjct: 784 GAASM-RCTPQGDWS 797



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 110/437 (25%), Positives = 161/437 (36%), Gaps = 81/437 (18%)

Query: 374  ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428
            EL  C  + +PP      ++T ++  N + G      C PG+DL G++ + C P G WS 
Sbjct: 1189 ELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSP 1248

Query: 429  SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484
                C V++C   L Q  HG +       L      V CDEG+RL+GS    C      S
Sbjct: 1249 EAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFV-CDEGFRLKGSSVSHCVLVGMRS 1307

Query: 485  QWDGPEPRCVERHCSTFQMPKDVIISPHN---CGKQP--AKFGTICYVSCRQGFILSGVK 539
             W+   P C    C     P  ++   H     G  P   +    C     +G   + + 
Sbjct: 1308 LWNNSVPVCEHIFCPN---PPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIG 1364

Query: 540  E-MLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEA---KTLEQQDSANVTWQIPTAKD 595
            E  +RCT+    N GV +       +P   C   + A   KT EQ   A+ T  I   + 
Sbjct: 1365 ESTIRCTSDPHGN-GVWS-------SPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEF 1416

Query: 596  NSGEKVSVHVHPAFTPPYLFPIGDVA-IVYTATDLSGNQASCIFHIKVIDAEPPVIDWCR 654
              G  ++    P +    +F I  +  +V+++ + +  + SC                  
Sbjct: 1417 PVGTSLNYECRPGYFGK-MFSISCLENLVWSSVEDNCRRKSC------------------ 1457

Query: 655  SPPPVQVSEKVHAAS----WDEPQFSDNSGAELVITRSHTQGDLFPQGETIVQYTATDPS 710
             PPP   +  VH  +         +S N G  L+ + S                T    S
Sbjct: 1458 GPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPS----------------TTCLVS 1501

Query: 711  GNNRTCDIHI-VIKGSPCEIPFTPVNGDFIC---TPDNTGVNCTLTCLEGYD----FTEG 762
            GNN T D    + +   CE P T  NGDF     T  + G   T  C  G D    F   
Sbjct: 1502 GNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELV 1561

Query: 763  STDKYYCAYED---GVW 776
                 YC  +D   GVW
Sbjct: 1562 GERSIYCTSKDDQVGVW 1578



 Score = 63.5 bits (153), Expect = 3e-09
 Identities = 54/195 (27%), Positives = 74/195 (37%), Gaps = 31/195 (15%)

Query: 312  YGKGLQYECTACPSG--TYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRAS 369
            YGK + Y C   P    T+   G      S I C     TS P             + + 
Sbjct: 1795 YGKEISYACDTHPDRGMTFNLIGE-----SSIRC-----TSDPQGNGV--------WSSP 1836

Query: 370  GQTCEL---VHCPALKPPENGYFIQNTCNNHF-NAACGVRCHPGFDLVGSSIILCLPNGL 425
               CEL     CP     +NG++I    + +         C PG+ LVG   I C   G+
Sbjct: 1837 APRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGI 1896

Query: 426  WSGSESYCRVRTCPHLRQPKHGHISCSTREML----YKTTCLVACDEGYRLEGSDKLTCQ 481
            WS  + YC+   C     P   +      EM     Y     + C++GY LEGS    CQ
Sbjct: 1897 WSQLDHYCKEVNCSF---PLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQ 1953

Query: 482  GNSQWDGPEPRCVER 496
             + +WD P  +C  R
Sbjct: 1954 ADDRWDPPLAKCTSR 1968



 Score = 63.2 bits (152), Expect = 5e-09
 Identities = 55/195 (28%), Positives = 81/195 (41%), Gaps = 24/195 (12%)

Query: 373  CELVHCPALKPPENGYFIQ-NTCNNHFNAACGVRCHPG------FDLVGSSIILCLPN-- 423
            C+ + C       NG FI  N  N H+ +    RC+ G      F+LVG   I C  N  
Sbjct: 1061 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDD 1120

Query: 424  --GLWSGSESYCRVRTCPHLRQPKH--GHISCSTREMLYKTTCLVA--CDEGYRLEGSDK 477
              G+WSG    C +   P+   P +    I  S    L+    +V   C  G+ ++G  +
Sbjct: 1121 QVGIWSGPAPQCII---PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1177

Query: 478  LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQP-AKFGTICYVSCRQGFILS 536
            + CQ  ++W+   P C  R C   Q P +++   H    Q     G   + SC  G+ L 
Sbjct: 1178 VKCQALNKWEPELPSC-SRVC---QPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLR 1233

Query: 537  GVKEMLRCTTSGKWN 551
            G    L CT  G W+
Sbjct: 1234 GAAS-LHCTPQGDWS 1247



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 55/226 (24%), Positives = 85/226 (37%), Gaps = 24/226 (10%)

Query: 373  CELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNG---LWSGS 429
            C    C     P NG    NT +  F +     C+ GF L+GS    CL +G    W   
Sbjct: 1452 CRRKSCGPPPEPFNGMVHINT-DTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKK 1510

Query: 430  ESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLV-ACDEG------YRLEGSDKLTCQG 482
               C + +C       +G    + R   +  T +   C  G      + L G   + C  
Sbjct: 1511 APICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTS 1570

Query: 483  NSQ----WDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGV 538
                   W  P PRC+  +  T    ++ I  P N  +       I    C+ GF++ G 
Sbjct: 1571 KDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGN--RSFFTLTEIIRFRCQPGFVMVG- 1627

Query: 539  KEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAK-TLEQQDS 583
               ++C T+G+W  G +   C  V  P    P+ +  + TL  QD+
Sbjct: 1628 SHTVQCQTNGRW--GPKLPHCSRVCQPP---PEILHGEHTLSHQDN 1668



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 72/289 (24%), Positives = 98/289 (33%), Gaps = 52/289 (17%)

Query: 307  CEKGYYGKGL-QYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGST---------S 356
            CE  Y  +G     CT  P G + PE     + SC    D     P G           +
Sbjct: 1679 CEPSYDLRGAASLHCT--PQGDWSPEAPRCTVKSC---DDFLGQLPHGRVLLPLNLQLGA 1733

Query: 357  PEDCVCREGYRASGQT-------------------CELVHCPALKPPENGY-----FIQN 392
                VC EG+R  G++                   CE + CP      NG      F   
Sbjct: 1734 KVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDI 1793

Query: 393  TCNNHFNAACGVRCHPG--FDLVGSSIILCLP----NGLWSGSESYCRVRT---CPHLRQ 443
                  + AC      G  F+L+G S I C      NG+WS     C +     CPH  +
Sbjct: 1794 PYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPK 1853

Query: 444  PKHGH-ISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQ 502
             ++GH I       L   T    CD GY L G   + C     W   +  C E +CS   
Sbjct: 1854 IQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPL 1913

Query: 503  MPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
                  IS     K+   +G    + C  G+ L G     +C    +W+
Sbjct: 1914 FMNG--ISKELEMKKVYHYGDYVTLKCEDGYTLEG-SPWSQCQADDRWD 1959



 Score = 55.5 bits (132), Expect = 1e-06
 Identities = 39/134 (29%), Positives = 59/134 (44%), Gaps = 10/134 (7%)

Query: 374  ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428
            +L HC  + +PP      ++T ++  N + G      C P +DL G++ + C P G WS 
Sbjct: 1642 KLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSP 1701

Query: 429  SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484
                C V++C   L Q  HG +       L      V CDEG+RL+G     C      +
Sbjct: 1702 EAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFV-CDEGFRLKGRSASHCVLAGMKA 1760

Query: 485  QWDGPEPRCVERHC 498
             W+   P C +  C
Sbjct: 1761 LWNSSVPVCEQIFC 1774



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 53/195 (27%), Positives = 83/195 (42%), Gaps = 23/195 (11%)

Query: 374 ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428
           EL  C  + +PP +    + T  +  N + G      C PG+DL G++ + C P G WS 
Sbjct: 289 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 348

Query: 429 SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484
           +   C V++C   + Q  +G +       L      V CDEG++L+GS    C      S
Sbjct: 349 AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV-CDEGFQLKGSSASYCVLAGMES 407

Query: 485 QWDGPEPRCVERHCSTFQMPKDVIISPHNCGK--QPAKFGTICYVSC------RQGFILS 536
            W+   P C +  C +      VI +  + GK  +   FG     +C         F L 
Sbjct: 408 LWNSSVPVCEQIFCPS----PPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463

Query: 537 GVKEMLRCTTSGKWN 551
           G +  +RCT+  + N
Sbjct: 464 G-ESTIRCTSDPQGN 477



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 53/195 (27%), Positives = 83/195 (42%), Gaps = 23/195 (11%)

Query: 374 ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428
           EL  C  + +PP +    + T  +  N + G      C PG+DL G++ + C P G WS 
Sbjct: 739 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 798

Query: 429 SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484
           +   C V++C   + Q  +G +       L      V CDEG++L+GS    C      S
Sbjct: 799 AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV-CDEGFQLKGSSASYCVLAGMES 857

Query: 485 QWDGPEPRCVERHCSTFQMPKDVIISPHNCGK--QPAKFGTICYVSC------RQGFILS 536
            W+   P C +  C +      VI +  + GK  +   FG     +C         F L 
Sbjct: 858 LWNSSVPVCEQIFCPS----PPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLI 913

Query: 537 GVKEMLRCTTSGKWN 551
           G +  +RCT+  + N
Sbjct: 914 G-ESTIRCTSDPQGN 927



 Score = 52.8 bits (125), Expect = 6e-06
 Identities = 44/177 (24%), Positives = 75/177 (42%), Gaps = 13/177 (7%)

Query: 406 CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA 465
           C PG+     SII CL N +W+G++  CR ++C +   P +G +    + + + +    +
Sbjct: 73  CRPGYSGRPFSII-CLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHV-IKGIQFGSQIKYS 130

Query: 466 CDEGYRLEGSDKLTC--QGNSQ-WDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKF 521
           C +GYRL GS   TC   G++  WD   P C    C    +P  +      +  ++   +
Sbjct: 131 CTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCG---LPPTITNGDFISTNRENFHY 187

Query: 522 GTICYVSCRQGF----ILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIE 574
           G++    C  G     +   V E     TS    VG+ +        P    P ++E
Sbjct: 188 GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVE 244



 Score = 46.2 bits (108), Expect = 6e-04
 Identities = 60/231 (25%), Positives = 78/231 (33%), Gaps = 42/231 (18%)

Query: 307 CEKGYYGKG-LQYECTACPSGTYKPEGSPGGISSCIPCPDENHTS----PPGSTSPEDCV 361
           C+ G+  KG  + +C A     ++PE  P     C P PD  H         + SP   V
Sbjct: 266 CQPGFVMKGPRRVKCQAL--NKWEPE-LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEV 322

Query: 362 ---CREGYRASGQ----------------TCELVHCPALKPPENGYFIQNTCNNHFNAAC 402
              C  GY   G                 TCE+  C           +    N    A  
Sbjct: 323 FYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKV 382

Query: 403 GVRCHPGFDLVGSSIILCLPNG---LWSGSESYCRVRTCPHLRQPKHGHISCSTREML-Y 458
              C  GF L GSS   C+  G   LW+ S   C    CP      +G  +    E+  +
Sbjct: 383 DFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPF 442

Query: 459 KTTCLVACDE------GYRLEGSDKLTC----QGNSQWDGPEPRC-VERHC 498
             T    CD        + L G   + C    QGN  W  P PRC +  HC
Sbjct: 443 GKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 493



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 61/231 (26%), Positives = 78/231 (33%), Gaps = 42/231 (18%)

Query: 307 CEKGYYGKG-LQYECTACPSGTYKPEGSPGGISSCIPCPDENHTS----PPGSTSPEDCV 361
           C+ G+  KG  + +C A     ++PE  P     C P PD  H         + SP   V
Sbjct: 716 CQPGFVMKGPRRVKCQAL--NKWEPE-LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEV 772

Query: 362 ---CREGYRASGQ----------------TCELVHCPALKPPENGYFIQNTCNNHFNAAC 402
              C  GY   G                 TCE+  C           +    N    A  
Sbjct: 773 FYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKV 832

Query: 403 GVRCHPGFDLVGSSIILCLPNG---LWSGSESYCRVRTCPHLRQPKHGHISCSTREML-- 457
              C  GF L GSS   C+  G   LW+ S   C    CP      +G  +    E+   
Sbjct: 833 DFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPF 892

Query: 458 ---YKTTCLVACDEG--YRLEGSDKLTC----QGNSQWDGPEPRC-VERHC 498
                 TC    D G  + L G   + C    QGN  W  P PRC +  HC
Sbjct: 893 GKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 943



 Score = 43.1 bits (100), Expect = 0.005
 Identities = 55/236 (23%), Positives = 77/236 (32%), Gaps = 47/236 (19%)

Query: 307  CEKGYYGKGL-QYECTACPSGTYKPEGSPGGISSCIPCPDE---NHTSPPGST---SPED 359
            CE GY  +G     CT  P G + P      + SC     +        P +    +  D
Sbjct: 776  CEPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVD 833

Query: 360  CVCREGYRASGQT-------------------CELVHCPALKPPENGYFIQNTCNNH-FN 399
             VC EG++  G +                   CE + CP+     NG           F 
Sbjct: 834  FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFG 893

Query: 400  AACGVRCHP------GFDLVGSSIILCLP----NGLWSGSESYCRVRTCPHLRQPKHGHI 449
             A    C P       FDL+G S I C      NG+WS     C +    H + P H   
Sbjct: 894  KAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI--LGHCQAPDHFLF 951

Query: 450  S-----CSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCST 500
            +      +  +    T+    C   Y       +TC  N  W  P+  C  + C T
Sbjct: 952  AKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKT 1006



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 36/165 (21%), Positives = 62/165 (37%), Gaps = 12/165 (7%)

Query: 418 ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477
           I CL N +WS  +  C+ ++C     P +G +   T ++   +    +C  G+RL G   
Sbjct: 534 ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGSRINYSCTTGHRLIGHSS 592

Query: 478 LTC--QGN-SQWDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKFGTICYVSCRQGF 533
             C   GN + W    P C    C    +P  +      +  ++   +G++    C  G 
Sbjct: 593 AECILSGNAAHWSTKPPICQRIPCG---LPPTIANGDFISTNRENFHYGSVVTYRCNPGS 649

Query: 534 ----ILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIE 574
               +   V E     TS    VG+ +        P    P ++E
Sbjct: 650 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVE 694



 Score = 36.6 bits (83), Expect = 0.46
 Identities = 23/84 (27%), Positives = 36/84 (42%), Gaps = 4/84 (4%)

Query: 418  ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477
            I CL N +WS  +  C+ ++C     P +G +   T ++   +    +C  G+RL G   
Sbjct: 984  ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGSRINYSCTTGHRLIGHSS 1042

Query: 478  LTC--QGN-SQWDGPEPRCVERHC 498
              C   GN + W    P C    C
Sbjct: 1043 AECILSGNTAHWSTKPPICQRIPC 1066


>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
          Length = 2489

 Score =  674 bits (1739), Expect = 0.0
 Identities = 550/2018 (27%), Positives = 805/2018 (39%), Gaps = 292/2018 (14%)

Query: 1642 RTASEDLKPGSKVNLFCDPGFQLVGNPVQY-CLNQGQWTQPLPHCERISCGVPPPLENGF 1700
            +T + D   G+ +   C P +   G P    CL+   W+ P   C+R SC  PP   NG 
Sbjct: 507  QTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGM 564

Query: 1701 -HSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSCLDVDECAVGSDCS 1756
             H   D   GS + Y C  G+ L+G S   C  +G+   W+   P C  +          
Sbjct: 565  VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIP--------- 615

Query: 1757 EHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQ 1816
                         C  +PP   +G   +         N EN H        G+ VT+ C 
Sbjct: 616  -------------CG-LPPTIANGDFIST--------NRENFH-------YGSVVTYRCN 646

Query: 1817 EG------YQLMGVTKITCLES----GEWNHLIPYCKAVSCGKPAIPENGCI---EELAF 1863
             G      ++L+G   I C  +    G W+   P C   +   P   ENG +       F
Sbjct: 647  PGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLF 706

Query: 1864 TFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTY 1923
            +    V +RC  G+ + G +   C A + W    P C  V C  P ++ + +        
Sbjct: 707  SLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDN 765

Query: 1924 LSTAS---YSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGE--PPAIKDAVITGNN 1978
             S      YSC+ GY L+G + + CT  G W  A P C +  C +     +   V+   N
Sbjct: 766  FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVN 825

Query: 1979 FTFRNTVTYTCKEGYTLAGLDTIECLADGK---WSRSDQQCLAVSCDEPPIVD---HASP 2032
                  V + C EG+ L G     C+  G    W+ S   C  + C  PP++    H   
Sbjct: 826  LQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGK 885

Query: 2033 ETAHRLFGDIAFYYCSD------GYSLADNSQLLCNAQ----GKWVPPEGQDMPRC-IAH 2081
                  FG    Y C         + L   S + C +     G W  P     PRC I  
Sbjct: 886  PLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPA----PRCGILG 941

Query: 2082 FCEKPPSVSYSILESVSKAK-FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQ 2140
             C+ P    ++ L++ + A  F  G+ + ++C   +       I C+    W+ SP  + 
Sbjct: 942  HCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY-GRPFSITCLDNLVWS-SPKDV- 998

Query: 2141 CIPVRCGEPPSIMNGYASG-SNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQ---WSSPI 2196
            C    C  PP  +NG     ++   G+ + YSC  G  + G   + C  +G    WS+  
Sbjct: 999  CKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKP 1058

Query: 2197 PTCHPVSCGEPPKVENGFLEHTTGRIFE--SEVRYQCNPG------YKSVGSPVFVCQAN 2248
            P C  + CG PP + NG    T    F   S V Y+CNPG      ++ VG P   C +N
Sbjct: 1059 PICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSN 1118

Query: 2249 RH----WHSESPLMCVPLDCGKPPPIQNGFMKGEN---FEVGSKVQFFCNEGYELVGDSS 2301
                  W   +P   +P  C  PP ++NG +  +N   F +   V+F C  G+ + G   
Sbjct: 1119 DDQVGIWSGPAPQCIIPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1177

Query: 2302 WTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVL--KELTTEVGVVTFSCKEGHVLQGPS 2359
              CQ   KW  +  P C     P P +L  +     K+  +    V +SC+ G+ L+G +
Sbjct: 1178 VKCQALNKWEPEL-PSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA 1236

Query: 2360 VLKCLPSQQWNDSFPVCKIVLCTP--PPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGN 2417
             ++C P   W+ + P C++  C      L++  V  P + L  G+ V + C  GF L+G+
Sbjct: 1237 SMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVN-LQLGAKVDFVCDEGFQLKGS 1295

Query: 2418 STTLCQPDGT---WSSPLPECVPVECPQPEEIPNGIIDVQGLAYL---STALYTCKP--- 2468
            S + C   G    W+S +P C  + CP P  IPNG    + L          YTC P   
Sbjct: 1296 SASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPD 1355

Query: 2469 ---GFELVGNTTTLCGE----NGHWLGGKPTCKAI-ECLKPKEILNGKF----SYTDLHY 2516
                F+L+G +T  C      NG W    P C  +  C  P   L  K     + +D   
Sbjct: 1356 RGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPI 1415

Query: 2517 GQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEG-ADYSYG 2575
            G ++ Y C   +    P ++TCL+   W      C    C +P    NG V    D   G
Sbjct: 1416 GTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVG 1474

Query: 2576 AIIIYSCFPGFQVAGHAMQTCEESG----WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQ 2631
            + I YSC  G ++ GH+   C  SG    WS+  P C  I CGLPP I  GD        
Sbjct: 1475 SRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFI------ 1528

Query: 2632 GYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPG--- 2688
                                                 +T+  NF YG++V+Y CN G   
Sbjct: 1529 -------------------------------------STNRENFHYGSVVTYRCNLGSRG 1551

Query: 2689 ---YELLGNPVLICQED----GTWNGSAPSCISIECDLPTAPENGFLRFTETSMGS---A 2738
               +EL+G P + C  +    G W+G AP CI      P   ENG L     S+ S    
Sbjct: 1552 RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEV 1611

Query: 2739 VQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGS---NYTYLS 2795
            V++ C+PG ++ G     C    KW    P C  + C+ P  +++G    S   N++   
Sbjct: 1612 VEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQ 1670

Query: 2796 TLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQ--- 2852
             ++Y C+PGY L G     C    +W  + P C    C        GQ+      F    
Sbjct: 1671 EVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDD----FLGQLPHGRVLFPLNL 1726

Query: 2853 ---KEIEYTCNEGFLLEGARSRVCLANGS---WSGATPDCVPVRCATPPQLANGVTEGLD 2906
                ++ + C+EGF L+G+    C+  G    W+ + P C  + C  PP + NG   G  
Sbjct: 1727 QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTP 1786

Query: 2907 YG---FMKEVTFHCHEG------YILHGAPKLTCQSD----GNWDAEIPLC----KPVNC 2949
             G   + KE+++ C         + L G   + C SD    G W +  P C    +  +C
Sbjct: 1787 SGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHC 1846

Query: 2950 GPPEDLAHGFP----NGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPC 3005
              PE      P    N F F  G  + Y+C PGY      S  CL N  WS    +C   
Sbjct: 1847 KTPEQFPFASPTIPINDFEFPVGTSLNYECRPGY-FGKMFSISCLENLVWSSVEDNCRRK 1905

Query: 3006 RCSTPVIEY-GTVN-GTDFDCGKAARIQCFKGFKLLGLSEITCEADGQ---WSSGFPHCE 3060
             C  P   + G V+  TD   G      C +GF+L+G    TC   G    W    P CE
Sbjct: 1906 SCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE 1965

Query: 3061 HTSCGSLPMIPNAFI---SETSSWKENVITYSCRSG------YVIQGSSDLICTEK---- 3107
              SC   P I N      + TS     V+TY C +G      + + G   + CT K    
Sbjct: 1966 IISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQV 2025

Query: 3108 GVWSQPYPVCEPLSCGSPPSVANAV---ATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQ 3164
            GVWS P P C   +  + P V NA+         T    ++ RC  G+ M   + T  CQ
Sbjct: 2026 GVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVM-VGSHTVQCQ 2084

Query: 3165 KDGRWFPERISCSPKKCPLPENI--THILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQ 3222
             +GRW P+   CS    P PE +   H L H D+FS  ++V  SC   Y   G     C 
Sbjct: 2085 TNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCT 2144

Query: 3223 LDGTWEPPFSDESCSPVSCGK--PESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERV 3280
              G W P      C+  SC     + P    ++       + + + C+ G+ L+G     
Sbjct: 2145 PQGDWSP--EAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASH 2202

Query: 3281 CQ---ENRQWSGGVAICKETRCETPLEFLNGK---ADIENRTTGPNVVYSCN----RG-- 3328
            C        W+  V +C++  C  P   LNG+       +   G  + Y+C+    RG  
Sbjct: 2203 CVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMT 2262

Query: 3329 YSLEGPSEAHCTE----NGTWSHPVPLCK---PNPCPVPFVIPENALLSEKE--FYVDQN 3379
            ++L G S   CT     NG WS P P C+   P  CP P  I     +      +     
Sbjct: 2263 FNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMT 2322

Query: 3380 VSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVH----YQYG 3435
            +S  C  G+LL G G I C     W+Q    C++++C  P  + N I++ +     Y YG
Sbjct: 2323 ISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFM-NGISKELEMKKVYHYG 2381

Query: 3436 DMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCR 3473
            D +T  C  GY LEG   S C  +  W  PP+ +   R
Sbjct: 2382 DYVTLKCEDGYTLEGSPWSQCQADDRW-DPPLAKCTSR 2418



 Score =  647 bits (1668), Expect = 0.0
 Identities = 563/2068 (27%), Positives = 844/2068 (40%), Gaps = 296/2068 (14%)

Query: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQ---WTQPLPHCERISCGVPPPLENGFH---SAD 1704
            GS++   C  G++L+G+    C+  G    W    P C+RI CG+PP + NG     + +
Sbjct: 124  GSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRE 183

Query: 1705 DFYAGSTVTYQCNNG------YYLLGDSRMFCTDN----GSWNGVSPSCLDVDECAV--- 1751
            +F+ GS VTY+CN G      + L+G+  ++CT N    G W+G +P C+  ++C     
Sbjct: 184  NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 243

Query: 1752 --GSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKA-----PGNP--------- 1795
              G   S++ S  +++      C P +   G      +KC+A     P  P         
Sbjct: 244  ENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR---RVKCQALNKWEPELPSCSRVCQPP 300

Query: 1796 ------ENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSC-- 1847
                  E      + ++ G EV +SC+ GY L G   + C   G+W+   P C+  SC  
Sbjct: 301  PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD 360

Query: 1848 -------GKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCL---ANSSWSHSP 1897
                   G+   P N          G+KV + C++G+ L G   S C+     S W+ S 
Sbjct: 361  FMGQLLNGRVLFPVN-------LQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 413

Query: 1898 PVCEPVKCSSPENINNGKYI---LSGLTYLSTASYSCD------TGYSLQGPSIIECTA- 1947
            PVCE + C SP  I NG++    L    +  T +Y+CD      T + L G S I CT+ 
Sbjct: 414  PVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 473

Query: 1948 ---SGIWDRAPPACHLV-FCGEPPAIKDAVI----TGNNFTFRNTVTYTCKEGYTLAGLD 1999
               +G+W    P C ++  C  P     A +      ++F    ++ Y C+  Y      
Sbjct: 474  PQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPF 532

Query: 2000 TIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRL-FGDIAFYYCSDGYSLADNSQ 2058
            +I CL +  WS     C   SC  PP   +        +  G    Y C+ G+ L  +S 
Sbjct: 533  SITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSS 592

Query: 2059 LLCNAQGK---W--VPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCM 2113
              C   G    W   PP  Q +P      C  PP+++     S ++  F  GSVV+++C 
Sbjct: 593  AECILSGNAAHWSTKPPICQRIP------CGLPPTIANGDFISTNRENFHYGSVVTYRCN 646

Query: 2114 EG------FVLNTSAKIECMRG----GQWN-PSPMSIQCIPVRCGEPPSIMNGYASGSN- 2161
             G      F L     I C       G W+ P+P  I  IP +C  PP++ NG     N 
Sbjct: 647  PGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI--IPNKC-TPPNVENGILVSDNR 703

Query: 2162 --YSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTT 2219
              +S   +V + C  GF +KG ++  C+A  +W   +P+C  V C  PP V +       
Sbjct: 704  SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRD 762

Query: 2220 GRIFE--SEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNG-FMK 2276
               F    EV Y C PGY   G+    C     W   +P   V         + NG  + 
Sbjct: 763  KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLF 822

Query: 2277 GENFEVGSKVQFFCNEGYELVGDSSWTCQKSGK---WNKKSNPKCMPAKCPEPPLLENQL 2333
              N ++G+KV F C+EG++L G S+  C  +G    WN  S P C    CP PP++ N  
Sbjct: 823  PVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN-SSVPVCEQIFCPSPPVIPNGR 881

Query: 2334 VL---KELTTEVGVVTFSCK------EGHVLQGPSVLKCLPSQQ----WNDSFPVCKIV- 2379
                  E+      V ++C           L G S ++C    Q    W+   P C I+ 
Sbjct: 882  HTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILG 941

Query: 2380 LCTPPPLISFG---VPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECV 2436
             C  P    F        +S    G+++KY C   ++ R  S T C  +  WSSP   C 
Sbjct: 942  HCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSIT-CLDNLVWSSPKDVCK 1000

Query: 2437 PVECPQPEEIPNGIIDV-QGLAYLSTALYTCKPGFELVGNTTTLC---GENGHWLGGKPT 2492
               C  P +  NG++ V   +   S   Y+C  G  L+G+++  C   G   HW    P 
Sbjct: 1001 RKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPI 1060

Query: 2493 CKAIECLKPKEILNGKFSYT---DLHYGQTVTYSCNRG------FRLEGPSALTCL---- 2539
            C+ I C  P  I NG F  T   + HYG  VTY CN G      F L G  ++ C     
Sbjct: 1061 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 1120

Query: 2540 ETGDWDVDAPSCNAIHCDSPQPIENGFVEGAD---YSYGAIIIYSCFPGFQVAGHAMQTC 2596
            + G W   AP C   +  +P  +ENG +   +   +S   ++ + C PGF + G     C
Sbjct: 1121 QVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1180

Query: 2597 EE-SGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLG 2655
            +  + W   +P+C  + C  PP +   + T+   D     QE       + +  P Y L 
Sbjct: 1181 QALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQE------VFYSCEPGYDLR 1233

Query: 2656 AVA--KTWENTKESPATHSS---------------------NFLYGTMVSYTCNPGYELL 2692
              A  +       SPA  +                      N   G  V + C+ G++L 
Sbjct: 1234 GAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLK 1293

Query: 2693 GNPVLICQEDG---TWNGSAPSCISIECDLPTAPENGFLRFTETSM-----GSAVQYSCK 2744
            G+    C   G    WN S P C  I C  P    NG  R T   +     G AV Y+C 
Sbjct: 1294 GSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG--RHTGKPLEVFPFGKAVNYTCD 1351

Query: 2745 PGHILAGSDLRLCLE-----------NRKWSGASPRCEAIS-CKKPNPVMNGSIK----G 2788
            P H   G+   L  E           N  WS  +PRC  +  C+ P+  +   +K     
Sbjct: 1352 P-HPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNA 1410

Query: 2789 SNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRG-D 2847
            S++   ++L YEC P Y        TC D+  W   + +C    C +PP   NG V    
Sbjct: 1411 SDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT 1469

Query: 2848 EYTFQKEIEYTCNEGFLLEGARSRVCLANGS---WSGATPDCVPVRCATPPQLANG---V 2901
            +      I Y+C  G  L G  S  C+ +G+   WS   P C  + C  PP +ANG    
Sbjct: 1470 DIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFIS 1529

Query: 2902 TEGLDYGFMKEVTFHCHEG------YILHGAPKLTCQSD----GNWDAEIPLC-KPVNCG 2950
            T   ++ +   VT+ C+ G      + L G P + C S+    G W    P C  P  C 
Sbjct: 1530 TNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCT 1589

Query: 2951 PPEDLAHGF---PNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRC 3007
            PP ++ +G     N   F     ++++C PG+ + G    +C +   W    PSC     
Sbjct: 1590 PP-NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQ 1648

Query: 3008 STPVI---EYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSC 3064
              P I   E+   +  +F  G+     C  G+ L G + + C   G WS   P C   SC
Sbjct: 1649 PPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSC 1708

Query: 3065 GS-LPMIPNAFISETSSWKENV-ITYSCRSGYVIQGSSDLICTEKG---VWSQPYPVCEP 3119
               L  +P+  +    + +    +++ C  G+ ++GSS   C   G   +W+   PVCE 
Sbjct: 1709 DDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEH 1768

Query: 3120 LSCGSPPSVANAVATGEAH---TYESEVKLRC----LEGYTMD-TDTDTFTCQKD----G 3167
            + C +PP++ N   TG       Y  E+   C      G T +     T  C  D    G
Sbjct: 1769 IFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNG 1828

Query: 3168 RWFPE----RISCSPKKCPLPENITH----ILVHGDDFSVNRQVSVSCAEGYTFEGVNIS 3219
             W        +S     C  PE        I ++  +F V   ++  C  GY  +  +IS
Sbjct: 1829 VWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSIS 1888

Query: 3220 VCQLDGTWEPPFSDESCSPVSCGKPESPEHGFV-VGSKYTFESTIIYQCEPGYELEGNRE 3278
             C  +  W     +++C   SCG P  P +G V + +   F ST+ Y C  G+ L G+  
Sbjct: 1889 -CLENLVWSS--VEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPS 1945

Query: 3279 RVC---QENRQWSGGVAICKETRCETPLEFLNGKADIENRTT---GPNVVYSCNRG---- 3328
              C     N  W     IC+   CE P    NG     NRT+   G  V Y C+ G    
Sbjct: 1946 TTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGE 2005

Query: 3329 --YSLEGPSEAHCTEN----GTWSHPVPLC-KPNPCPVPFVIPENALL---SEKEFYVDQ 3378
              + L G    +CT      G WS P P C   N C  P V  ENA+    +   F + +
Sbjct: 2006 QLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEV--ENAIRVPGNRSFFTLTE 2063

Query: 3379 NVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPP---AHVENAIARGVHYQYG 3435
             +  +C+ GF++ G   + C  +  W      C ++ C PP    H E+ ++   ++  G
Sbjct: 2064 IIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPG 2122

Query: 3436 DMITYSCYSGYMLEGFLRSVCLENGTWT 3463
              + YSC   Y L G     C   G W+
Sbjct: 2123 QEVFYSCEPSYDLRGAASLHCTPQGDWS 2150



 Score =  616 bits (1588), Expect = e-175
 Identities = 559/2068 (27%), Positives = 802/2068 (38%), Gaps = 308/2068 (14%)

Query: 1646 EDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCG--VPPPLENGFHSA 1703
            ++  PG +V   C+PG+ L G     C  QG W+   P CE  SC   +   L       
Sbjct: 314  DNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP 373

Query: 1704 DDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSCLDVDEC----------- 1749
             +   G+ V + C+ G+ L G S  +C   G    WN   P C  +  C           
Sbjct: 374  VNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQI-FCPSPPVIPNGRH 432

Query: 1750 ------------AVGSDCSEH---ASCLNVDGSYICSCVPPYTGDG------KNCAEPIK 1788
                         V   C  H    +  ++ G     C     G+G        C     
Sbjct: 433  TGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGH 492

Query: 1789 CKAPGN----PENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKA 1844
            C+AP +         ++   + +G  + + C+  Y     + ITCL++  W+     CK 
Sbjct: 493  CQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKR 551

Query: 1845 VSCGKPAIPENGCIEELA-FTFGSKVTYRCNKGYTLAGDKESSCLANSS---WSHSPPVC 1900
             SC  P  P NG +  +     GS++ Y C  G+ L G   + C+ + +   WS  PP+C
Sbjct: 552  KSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPIC 611

Query: 1901 EPVKCSSPENINNGKYILS---GLTYLSTASYSCDTG------YSLQGPSIIECTAS--- 1948
            + + C  P  I NG +I +      Y S  +Y C+ G      + L G   I CT++   
Sbjct: 612  QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671

Query: 1949 -GIWDRAPPACHLVFCGEPPAIKDAVITGNN---FTFRNTVTYTCKEGYTLAGLDTIECL 2004
             GIW    P C +     PP +++ ++  +N   F+    V + C+ G+ + G   ++C 
Sbjct: 672  VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 731

Query: 2005 ADGKWSRSDQQCLAVSCDEPPIVDHASPETAHR---LFGDIAFYYCSDGYSLADNSQLLC 2061
            A  KW      C  V C  PP V HA      +     G   FY C  GY L   + + C
Sbjct: 732  ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC 790

Query: 2062 NAQGKWVPPEGQDMPRCIAHFCE--KPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLN 2119
              QG W P      P C    C+      ++  +L  V+      G+ V F C EGF L 
Sbjct: 791  TPQGDWSPA----APTCEVKSCDDFMGQLLNGRVLFPVN---LQLGAKVDFVCDEGFQLK 843

Query: 2120 TSAKIECMRGGQ---WNPS-PMSIQCIPVRCGEPPSIMNGYASGSN---YSFGAMVAYSC 2172
             S+   C+  G    WN S P+   C  + C  PP I NG  +G     + FG  V Y+C
Sbjct: 844  GSSASYCVLAGMESLWNSSVPV---CEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTC 900

Query: 2173 N------KGFYIKGEKKSTC----EATGQWSSPIPTCHPVS-CGEPPKVENGFLEHTTGR 2221
            +        F + GE    C    +  G WSSP P C  +  C  P       L+  T  
Sbjct: 901  DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNA 960

Query: 2222 I---FESEVRYQCNPGYKSVGSPVFV-CQANRHWHSESPLMCVPLDCGKPPPIQNGFMKG 2277
                  + ++Y+C P Y   G P  + C  N  W S    +C    C  PP   NG +  
Sbjct: 961  SDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKD-VCKRKSCKTPPDPVNGMVHV 1017

Query: 2278 -ENFEVGSKVQFFCNEGYELVGDSSWTCQKSGK---WNKKSNPKCMPAKCPEPPLLENQL 2333
              + +VGS++ + C  G+ L+G SS  C  SG    W+ K  P C    C  PP + N  
Sbjct: 1018 ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKP-PICQRIPCGLPPTIANGD 1076

Query: 2334 VL---KELTTEVGVVTFSCKEG------HVLQGPSVLKCLPSQQ----WNDSFPVCKIVL 2380
             +   +E      VVT+ C  G        L G   + C  +      W+   P C I  
Sbjct: 1077 FISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN 1136

Query: 2381 CTPPPLISFGVPIPS--SALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPV 2438
               PP +  G+ +    S       V++ C  GF ++G     CQ    W   LP C  V
Sbjct: 1137 KCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV 1196

Query: 2439 ECPQPEEI--PNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAI 2496
              P P+ +       D    +      Y+C+PG++L G  +  C   G W    PTC+  
Sbjct: 1197 CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVK 1256

Query: 2497 ECLK-PKEILNGKFSY-TDLHYGQTVTYSCNRGFRLEGPSALTCLETGD---WDVDAPSC 2551
             C     ++LNG+  +  +L  G  V + C+ GF+L+G SA  C+  G    W+   P C
Sbjct: 1257 SCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 1316

Query: 2552 NAIHCDSPQPIENGFVEGAD---YSYGAIIIYSCFP------GFQVAGHAMQTCEESG-- 2600
              I C SP  I NG   G     + +G  + Y+C P       F + G +   C      
Sbjct: 1317 EQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQG 1376

Query: 2601 ---WSSSIPTCMPI-DCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGA 2656
               WSS  P C  +  C  P H  F    KLK                            
Sbjct: 1377 NGVWSSPAPRCGILGHCQAPDHFLF---AKLKTQ-------------------------- 1407

Query: 2657 VAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLI-CQEDGTWNGSAPSCISI 2715
                         T++S+F  GT + Y C P Y   G P  I C ++  W+     C   
Sbjct: 1408 -------------TNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRK 1452

Query: 2716 ECDLPTAPENGFLR-FTETSMGSAVQYSCKPGHILAGSDLRLCL---ENRKWSGASPRCE 2771
             C  P  P NG +   T+  +GS + YSC  GH L G     C+       WS   P C+
Sbjct: 1453 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1512

Query: 2772 AISCKKPNPVMNG---SIKGSNYTYLSTLYYECDPG------YVLNGTERRTCQDDKN-- 2820
             I C  P  + NG   S    N+ Y S + Y C+ G      + L G     C  + +  
Sbjct: 1513 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1572

Query: 2821 --WDEDEPICIPVDCSSPPVSANGQVRGDE---YTFQKEIEYTCNEGFLLEGARSRVCLA 2875
              W    P CI  +  +PP   NG +  D    ++  + +E+ C  GF+++G R   C A
Sbjct: 1573 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 1632

Query: 2876 NGSWSGATPDCVPVRCATPPQLANG---VTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQ 2932
               W    P C  V C  PP++ +G    +   ++   +EV + C  GY L GA  L C 
Sbjct: 1633 LNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCT 1691

Query: 2933 SDGNWDAEIPLCKPVNCGPPEDLAHGFPNG-----FSFIHGGHIQYQCFPGYKLHGNSSR 2987
              G+W  E P C   +C   +D     P+G      +   G  + + C  G++L G+S  
Sbjct: 1692 PQGDWSPEAPRCAVKSC---DDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVS 1748

Query: 2988 RCLSNGS---WSGSSPSCLPCRC-STPVIEYGTVNGT---DFDCGKAARIQC------FK 3034
             C+  G    W+ S P C    C + P I  G   GT   D   GK     C        
Sbjct: 1749 HCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGM 1808

Query: 3035 GFKLLGLSEITCEAD----GQWSSGFPHCEHTSCGSLPMIPNAF--------ISETSSWK 3082
             F L+G S I C +D    G WSS  P CE +        P  F        I++     
Sbjct: 1809 TFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPV 1868

Query: 3083 ENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHT-YE 3141
               + Y CR GY  +  S + C E  VWS     C   SCG PP   N +      T + 
Sbjct: 1869 GTSLNYECRPGYFGKMFS-ISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFG 1927

Query: 3142 SEVKLRCLEGYTMDTDTDTFTCQKDGR---WFPERISCSPKKCPLPENITHILVHGDDFS 3198
            S V   C EG+ +     T TC   G    W  +   C    C  P  I+    +GD +S
Sbjct: 1928 STVNYSCNEGFRLIGSPST-TCLVSGNNVTWDKKAPICEIISCEPPPTIS----NGDFYS 1982

Query: 3199 VNRQ-------VSVSCAEG------YTFEGVNISVCQLD----GTWEPPFSDESCSPVSC 3241
             NR        V+  C  G      +   G     C       G W  P      S   C
Sbjct: 1983 NNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSP-PPRCISTNKC 2041

Query: 3242 GKPESPEHGFVVGSK--YTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRC 3299
              PE      V G++  +T    I ++C+PG+ + G+    CQ N +W   +  C    C
Sbjct: 2042 TAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-C 2100

Query: 3300 ETPLEFLNGKADI---ENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNP 3356
            + P E L+G+  +   +N + G  V YSC   Y L G +  HCT  G WS   P C    
Sbjct: 2101 QPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKS 2160

Query: 3357 CPVPFV--IPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC---NPDETWTQTSAKC 3411
            C   F+  +P   +L      +   VS  C EGF L+G     C        W  +   C
Sbjct: 2161 CD-DFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVC 2219

Query: 3412 EKISCGPPAHVENAIARGVHY---QYGDMITYSCYS------GYMLEGFLRSVCLE---- 3458
            E+I C  P  + N    G  +    YG  I+Y+C +       + L G     C      
Sbjct: 2220 EQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQG 2279

Query: 3459 NGTWTSP-PICR----AVCRFP--CQNG 3479
            NG W+SP P C     A C  P   QNG
Sbjct: 2280 NGVWSSPAPRCELSVPAACPHPPKIQNG 2307



 Score =  613 bits (1581), Expect = e-175
 Identities = 564/2067 (27%), Positives = 799/2067 (38%), Gaps = 271/2067 (13%)

Query: 1651 GSKVNLFCDPGFQLVGNPVQY-CLNQGQWTQPLPHCERISCGVPPPLENGF-HSADDFYA 1708
            G+ +N  C PG+   G P    CL    WT     C R SC  PP   NG  H       
Sbjct: 66   GTYLNYECRPGYS--GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQF 123

Query: 1709 GSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSCLDVD------------------ 1747
            GS + Y C  GY L+G S   C  +G    W+  +P C  +                   
Sbjct: 124  GSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRE 183

Query: 1748 ----------ECAVGSDCSEHASCLNVDGSYICS---CVPPYTGDGKNCAEPIKCKAPGN 1794
                       C  GS   +    +     Y  S    V  ++G    C  P KC  P N
Sbjct: 184  NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKC-TPPN 242

Query: 1795 PENG---HSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPA 1851
             ENG     +  ++++   V F CQ G+ + G  ++ C    +W   +P C  V    P 
Sbjct: 243  VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPD 302

Query: 1852 I--PENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSS-P 1908
            +   E    ++  F+ G +V Y C  GY L G     C     WS + P CE   C    
Sbjct: 303  VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFM 362

Query: 1909 ENINNGKYILS-GLTYLSTASYSCDTGYSLQGPSIIECTASG---IWDRAPPACHLVFCG 1964
              + NG+ +    L   +   + CD G+ L+G S   C  +G   +W+ + P C  +FC 
Sbjct: 363  GQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCP 422

Query: 1965 EPPAIKDAVITGNN---FTFRNTVTYTCK------EGYTLAGLDTIECLAD----GKWSR 2011
             PP I +   TG     F F  TV YTC         + L G  TI C +D    G WS 
Sbjct: 423  SPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS 482

Query: 2012 SDQQC-LAVSCDEPPIVDHASPETAHRL----FGDIAFYYCSDGYSLADNSQLLCNAQGK 2066
               +C +   C  P     A  +T         G    Y C   Y       + C     
Sbjct: 483  PAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLV 541

Query: 2067 WVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIEC 2126
            W  P+      C    C+ PP     ++  ++  +   GS +++ C  G  L   +  EC
Sbjct: 542  WSSPKDV----CKRKSCKTPPDPVNGMVHVITDIQ--VGSRINYSCTTGHRLIGHSSAEC 595

Query: 2127 MRGG---QWNPSPMSIQCIPVRCGEPPSIMNG---YASGSNYSFGAMVAYSCNKG----- 2175
            +  G    W+  P   Q IP  CG PP+I NG     +  N+ +G++V Y CN G     
Sbjct: 596  ILSGNAAHWSTKPPICQRIP--CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRK 653

Query: 2176 -FYIKGEKKSTC----EATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIF--ESEVR 2228
             F + GE    C    +  G WS P P C   +   PP VENG L      +F     V 
Sbjct: 654  VFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVE 713

Query: 2229 YQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPI---QNGFMKGENFEVGSK 2285
            ++C PG+   G     CQA   W  E P  C  + C  PP +   +      +NF  G +
Sbjct: 714  FRCQPGFVMKGPRRVKCQALNKWEPELP-SCSRV-CQPPPDVLHAERTQRDKDNFSPGQE 771

Query: 2286 VQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPE-PPLLENQLVLKELTTEVGV 2344
            V + C  GY+L G +S  C   G W+  + P C    C +    L N  VL  +  ++G 
Sbjct: 772  VFYSCEPGYDLRGAASMRCTPQGDWSPAA-PTCEVKSCDDFMGQLLNGRVLFPVNLQLGA 830

Query: 2345 -VTFSCKEGHVLQGPSVLKCL---PSQQWNDSFPVCKIVLCTPPPLISFG--VPIPSSAL 2398
             V F C EG  L+G S   C+       WN S PVC+ + C  PP+I  G     P    
Sbjct: 831  KVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVF 890

Query: 2399 HFGSTVKYSC------VGGFFLRGNSTTLC----QPDGTWSSPLPEC-VPVECPQPEEIP 2447
             FG TV Y+C         F L G ST  C    Q +G WSSP P C +   C  P+   
Sbjct: 891  PFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFL 950

Query: 2448 NGIIDVQGLAY---LSTAL-YTCKPGFELVGNTTTL-CGENGHWLGGKPTCKAIECLKPK 2502
               +  Q  A    + T+L Y C+P  E  G   ++ C +N  W   K  CK   C  P 
Sbjct: 951  FAKLKTQTNASDFPIGTSLKYECRP--EYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPP 1008

Query: 2503 EILNGKFS-YTDLHYGQTVTYSCNRGFRLEGPSALTCLETGD---WDVDAPSCNAIHCDS 2558
            + +NG     TD+  G  + YSC  G RL G S+  C+ +G+   W    P C  I C  
Sbjct: 1009 DPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGL 1068

Query: 2559 PQPIENG---FVEGADYSYGAIIIYSCFPG------FQVAGHAMQTCEESG-----WSSS 2604
            P  I NG        ++ YG+++ Y C PG      F++ G     C  +      WS  
Sbjct: 1069 PPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP 1128

Query: 2605 IPTCMPIDCGLPPHIDFGDCTKLKDDQGYF---EQEDDMMEVPYVTPHPPYHLGAVAKTW 2661
             P C+  +   PP+++ G    + D++  F   E  +   +  +V   P          W
Sbjct: 1129 APQCIIPNKCTPPNVENG--ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 1186

Query: 2662 ENT----------------KESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTW 2705
            E                   E       NF  G  V Y+C PGY+L G   + C   G W
Sbjct: 1187 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDW 1246

Query: 2706 NGSAPSCISIEC-DLPTAPENGFLRF-TETSMGSAVQYSCKPGHILAGSDLRLCL---EN 2760
            + +AP+C    C D      NG + F     +G+ V + C  G  L GS    C+     
Sbjct: 1247 SPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 1306

Query: 2761 RKWSGASPRCEAISCKKPNPVMNGSIKGSN---YTYLSTLYYECDP------GYVLNGTE 2811
              W+ + P CE I C  P  + NG   G     + +   + Y CDP       + L G  
Sbjct: 1307 SLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGES 1366

Query: 2812 RRTCQDDKN----WDEDEPIC-IPVDCSSPP----VSANGQVRGDEYTFQKEIEYTCNEG 2862
               C  D      W    P C I   C +P          Q    ++     ++Y C   
Sbjct: 1367 TIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPE 1426

Query: 2863 FLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGL-DYGFMKEVTFHCHEGY 2921
            +      S  CL N  WS     C    C TPP   NG+   + D      + + C  G+
Sbjct: 1427 Y-YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGH 1485

Query: 2922 ILHGAPKLTCQSDGN---WDAEIPLCKPVNCGPPEDLAHG---FPNGFSFIHGGHIQYQC 2975
             L G     C   GN   W  + P+C+ + CG P  +A+G     N  +F +G  + Y+C
Sbjct: 1486 RLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRC 1545

Query: 2976 FPG------YKLHGNSSRRCLSN----GSWSGSSPSC-LPCRCSTPVIEYGTV---NGTD 3021
              G      ++L G  S  C SN    G WSG +P C +P +C+ P +E G +   N + 
Sbjct: 1546 NLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL 1605

Query: 3022 FDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSW 3081
            F   +    +C  GF + G   + C+A  +W    P C    C   P I +     T S 
Sbjct: 1606 FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPEILHG--EHTPSH 1662

Query: 3082 KENV-----ITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSC----GSPPSVANAV 3132
            ++N      + YSC  GY ++G++ L CT +G WS   P C   SC    G  P     V
Sbjct: 1663 QDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPH--GRV 1720

Query: 3133 ATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGR--WFPERISCSPKKCPLPE---NI 3187
                     ++V   C EG+ +   + +       R  W      C    CP P    N 
Sbjct: 1721 LFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNG 1780

Query: 3188 THILVHGDDFSVNRQVSVSC----AEGYTFEGVNISV--CQLD----GTWEPPFSDESCS 3237
             H      D    +++S +C      G TF  +  S   C  D    G W  P      S
Sbjct: 1781 RHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELS 1840

Query: 3238 PVSCGKPESPEHGFVVGS--------KYTFESTIIYQCEPGYELEGNRERV-CQENRQWS 3288
             V  G  ++PE  F   S        ++   +++ Y+C PGY   G    + C EN  WS
Sbjct: 1841 -VRAGHCKTPEQ-FPFASPTIPINDFEFPVGTSLNYECRPGY--FGKMFSISCLENLVWS 1896

Query: 3289 GGVAICKETRCETPLEFLNGKADIENRTT-GPNVVYSCNRGYSLEGPSEAHCTENG---T 3344
                 C+   C  P E  NG   I   T  G  V YSCN G+ L G     C  +G   T
Sbjct: 1897 SVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVT 1956

Query: 3345 WSHPVPLCKPNPCPVPFVIPENALLSEK--EFYVDQNVSIKCREG------FLLQGHGII 3396
            W    P+C+   C  P  I      S     F+    V+ +C  G      F L G   I
Sbjct: 1957 WDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSI 2016

Query: 3397 TCNPDE----TWTQTSAKCEKISCGPPAHVENAI---ARGVHYQYGDMITYSCYSGYMLE 3449
             C   +     W+    +C   +      VENAI        +   ++I + C  G+++ 
Sbjct: 2017 YCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMV 2076

Query: 3450 GFLRSVCLENGTW-TSPPICRAVCRFP 3475
            G     C  NG W    P C  VC+ P
Sbjct: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPP 2103



 Score =  587 bits (1512), Expect = e-167
 Identities = 513/1845 (27%), Positives = 745/1845 (40%), Gaps = 272/1845 (14%)

Query: 1859 EELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGK-YI 1917
            +E  F  G+ + Y C  GY+        CL NS W+ +   C    C +P +  NG  ++
Sbjct: 59   DEFEFPIGTYLNYECRPGYS-GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHV 117

Query: 1918 LSGLTYLSTASYSCDTGYSLQGPSIIECTASG---IWDRAPPACHLVFCGEPPAIK--DA 1972
            + G+ + S   YSC  GY L G S   C  SG   IWD   P C  + CG PP I   D 
Sbjct: 118  IKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDF 177

Query: 1973 VITGN-NFTFRNTVTYTCKEG------YTLAGLDTIECLAD----GKWSRSDQQCLAVSC 2021
            + T   NF + + VTY C  G      + L G  +I C ++    G WS    QC+  + 
Sbjct: 178  ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 237

Query: 2022 DEPPIVDHASPETAHR-LFG--DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRC 2078
              PP V++    + +R LF   ++  + C  G+ +    ++ C A  KW P    ++P C
Sbjct: 238  CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEP----ELPSC 293

Query: 2079 IAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMS 2138
             +  C+ PP V ++      K  F+ G  V + C  G+ L  +A + C   G W+P+  +
Sbjct: 294  -SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPT 352

Query: 2139 IQCIPVRCGE-PPSIMNGYASGS-NYSFGAMVAYSCNKGFYIKGEKKSTCEATGQ---WS 2193
              C    C +    ++NG      N   GA V + C++GF +KG   S C   G    W+
Sbjct: 353  --CEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN 410

Query: 2194 SPIPTCHPVSCGEPPKVENGFLEHTTGRI----FESEVRYQCNP------GYKSVGSPVF 2243
            S +P C  + C  PP + NG   HT   +    F   V Y C+P       +  +G    
Sbjct: 411  SSVPVCEQIFCPSPPVIPNG--RHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTI 468

Query: 2244 VC----QANRHWHSESPLMCVPLDCGKPPPIQNGFMKGE----NFEVGSKVQFFCNEGYE 2295
             C    Q N  W S +P   +   C  P       +K +    +F +G+ +++ C   Y 
Sbjct: 469  RCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY- 527

Query: 2296 LVGDSSWTCQKSGKWNKKSNPK--CMPAKCPEPPLLENQLVLKELTTEVGV-VTFSCKEG 2352
                 S TC  +  W   S+PK  C    C  PP   N +V      +VG  + +SC  G
Sbjct: 528  YGRPFSITCLDNLVW---SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTG 584

Query: 2353 HVLQGPSVLKCLPS---QQWNDSFPVCKIVLCTPPPLISFGVPIPSSA--LHFGSTVKYS 2407
            H L G S  +C+ S     W+   P+C+ + C  PP I+ G  I ++    H+GS V Y 
Sbjct: 585  HRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYR 644

Query: 2408 CVGG------FFLRGNSTTLCQPD----GTWSSPLPECV-PVECPQPEEIPNGII--DVQ 2454
            C  G      F L G  +  C  +    G WS P P+C+ P +C  P  + NGI+  D +
Sbjct: 645  CNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN-VENGILVSDNR 703

Query: 2455 GLAYLSTAL-YTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTD 2513
             L  L+  + + C+PGF + G     C     W    P+C  + C  P ++L+ + +  D
Sbjct: 704  SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRD 762

Query: 2514 ---LHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDS--PQPIENGFVE 2568
                  GQ V YSC  G+ L G +++ C   GDW   AP+C    CD    Q +    + 
Sbjct: 763  KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLF 822

Query: 2569 GADYSYGAIIIYSCFPGFQVAGHAMQTC----EESGWSSSIPTCMPIDCGLP-------- 2616
              +   GA + + C  GFQ+ G +   C     ES W+SS+P C  I C  P        
Sbjct: 823  PVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRH 882

Query: 2617 -------------------PHIDFGD-----------CTKLKDDQGYFEQEDDMMEVPYV 2646
                               PH D G            CT      G +        +   
Sbjct: 883  TGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGH 942

Query: 2647 TPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLI-CQEDGTW 2705
               P + L A  KT         T++S+F  GT + Y C P Y   G P  I C ++  W
Sbjct: 943  CQAPDHFLFAKLKT--------QTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVW 992

Query: 2706 NGSAPSCISIECDLPTAPENGFLR-FTETSMGSAVQYSCKPGHILAGSDLRLCL---ENR 2761
            +     C    C  P  P NG +   T+  +GS + YSC  GH L G     C+      
Sbjct: 993  SSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAA 1052

Query: 2762 KWSGASPRCEAISCKKPNPVMNG---SIKGSNYTYLSTLYYECDPG------YVLNGTER 2812
             WS   P C+ I C  P  + NG   S    N+ Y S + Y C+PG      + L G   
Sbjct: 1053 HWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS 1112

Query: 2813 RTCQDDKN----WDEDEPICIPVDCSSPPVSANGQVRGDE---YTFQKEIEYTCNEGFLL 2865
              C  + +    W    P CI  +  +PP   NG +  D    ++  + +E+ C  GF++
Sbjct: 1113 IYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVM 1172

Query: 2866 EGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLD---YGFMKEVTFHCHEGYI 2922
            +G R   C A   W    P C  V C  PP + +      D   +   +EV + C  GY 
Sbjct: 1173 KGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYD 1231

Query: 2923 LHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNG-----FSFIHGGHIQYQCFP 2977
            L GA  + C   G+W    P C+  +C   +D      NG      +   G  + + C  
Sbjct: 1232 LRGAASMRCTPQGDWSPAAPTCEVKSC---DDFMGQLLNGRVLFPVNLQLGAKVDFVCDE 1288

Query: 2978 GYKLHGNSSRRCLSNGS---WSGSSPSCLPCRC-STPVIEYGTVNGTD---FDCGKAARI 3030
            G++L G+S+  C+  G    W+ S P C    C S PVI  G   G     F  GKA   
Sbjct: 1289 GFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNY 1348

Query: 3031 QC------FKGFKLLGLSEITCEAD----GQWSSGFPHC---------EHTSCGSLPMIP 3071
             C         F L+G S I C +D    G WSS  P C         +H     L    
Sbjct: 1349 TCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQT 1408

Query: 3072 NA--FISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVA 3129
            NA  F   TS      + Y CR  Y  +  S + C +  VWS P  VC+  SC +PP   
Sbjct: 1409 NASDFPIGTS------LKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKTPPDPV 1461

Query: 3130 NAVATGEAHTYE-----SEVKLRCLEGYTM--DTDTDTFTCQKDGRWFPERISCSPKKCP 3182
            N    G  H        S +   C  G+ +   +  +         W  +   C    C 
Sbjct: 1462 N----GMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCG 1517

Query: 3183 LPENITHILVHGDDFSVNRQ-------VSVSCAEG------YTFEGVNISVCQLD----G 3225
            LP  I     +GD  S NR+       V+  C  G      +   G     C  +    G
Sbjct: 1518 LPPTI----ANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1573

Query: 3226 TWEPPFSDESCSPVSCGKPESPEHGFVVG---SKYTFESTIIYQCEPGYELEGNRERVCQ 3282
             W  P + +   P  C  P + E+G +V    S ++    + ++C+PG+ ++G R   CQ
Sbjct: 1574 IWSGP-APQCIIPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQ 1631

Query: 3283 ENRQWSGGVAICKETRCETPLEFLNGK---ADIENRTTGPNVVYSCNRGYSLEGPSEAHC 3339
               +W   +  C    C+ P E L+G+   +  +N + G  V YSC  GY L G +  HC
Sbjct: 1632 ALNKWEPELPSCSRV-CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHC 1690

Query: 3340 TENGTWSHPVPLCKPNPCPVPFV--IPENALLSEKEFYVDQNVSIKCREGFLLQGHGIIT 3397
            T  G WS   P C    C   F+  +P   +L      +   VS  C EGF L+G  +  
Sbjct: 1691 TPQGDWSPEAPRCAVKSCD-DFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSH 1749

Query: 3398 C---NPDETWTQTSAKCEKISCGPPAHVENAIARGV---HYQYGDMITYSC------YSG 3445
            C        W  +   CE I C  P  + N    G       YG  I+Y+C         
Sbjct: 1750 CVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMT 1809

Query: 3446 YMLEGFLRSVCLE----NGTWTSP-PICRAVCRFPCQNGGICQRP 3485
            + L G     C      NG W+SP P C    R      G C+ P
Sbjct: 1810 FNLIGESTIRCTSDPHGNGVWSSPAPRCELSVR-----AGHCKTP 1849



 Score =  295 bits (756), Expect = 4e-79
 Identities = 230/833 (27%), Positives = 342/833 (41%), Gaps = 92/833 (11%)

Query: 2719 LPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKP 2778
            LP A         E  +G+ + Y C+PG+      + +CL+N  W+GA  RC   SC+ P
Sbjct: 49   LPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTGAKDRCRRKSCRNP 107

Query: 2779 NPVMNGS---IKGSNYTYLSTLYYECDPGYVLNGTERRTC---QDDKNWDEDEPICIPVD 2832
               +NG    IKG  +   S + Y C  GY L G+   TC    D   WD + PIC  + 
Sbjct: 108  PDPVNGMVHVIKGIQFG--SQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIP 165

Query: 2833 CSSPPVSANG---QVRGDEYTFQKEIEYTCNEG------FLLEGARSRVCLAN----GSW 2879
            C  PP   NG       + + +   + Y CN G      F L G  S  C +N    G W
Sbjct: 166  CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225

Query: 2880 SGATPDCVPVRCATPPQLANGVTEGLD---YGFMKEVTFHCHEGYILHGAPKLTCQSDGN 2936
            SG  P C+     TPP + NG+    +   +   + V F C  G+++ G  ++ CQ+   
Sbjct: 226  SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 285

Query: 2937 WDAEIPLCKPVNCGPPEDLAHG---FPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNG 2993
            W+ E+P C  V C PP D+ H      +  +F  G  + Y C PGY L G +S RC   G
Sbjct: 286  WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQG 344

Query: 2994 SWSGSSPSCLPCRCST---PVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADG 3050
             WS ++P+C    C      ++    +   +   G      C +GF+L G S   C   G
Sbjct: 345  DWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAG 404

Query: 3051 Q---WSSGFPHCEHTSCGSLPMIPNAFISETSSWKE-----NVITYSC------RSGYVI 3096
                W+S  P CE   C S P+IPN     T    E       + Y+C       + + +
Sbjct: 405  MESLWNSSVPVCEQIFCPSPPVIPNG--RHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDL 462

Query: 3097 QGSSDLICTE----KGVWSQPYPVCEPLS-CGSPPSVANAVATGEAHTYE----SEVKLR 3147
             G S + CT      GVWS P P C  L  C +P     A    + +  +    + +K  
Sbjct: 463  IGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYE 522

Query: 3148 CLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHG-DDFSVNRQVSVS 3206
            C   Y       + TC  +  W   +  C  K C  P +  + +VH   D  V  +++ S
Sbjct: 523  CRPEYY--GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYS 580

Query: 3207 CAEGYTFEGVNISVCQLDGT---W--EPPFSDESCSPVSCGKPESPEHGFVVGS---KYT 3258
            C  G+   G + + C L G    W  +PP     C  + CG P +  +G  + +    + 
Sbjct: 581  CTTGHRLIGHSSAECILSGNAAHWSTKPPI----CQRIPCGLPPTIANGDFISTNRENFH 636

Query: 3259 FESTIIYQCEPG------YELEGNRERVCQENRQ----WSGGVAICKETRCETPLEFLNG 3308
            + S + Y+C PG      +EL G     C  N      WSG    C      TP    NG
Sbjct: 637  YGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENG 696

Query: 3309 KADIENR---TTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPE 3365
                +NR   +    V + C  G+ ++GP    C     W   +P C     P P V+  
Sbjct: 697  ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHA 756

Query: 3366 NALLSEKE-FYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGP--PAHV 3422
                 +K+ F   Q V   C  G+ L+G   + C P   W+  +  CE  SC       +
Sbjct: 757  ERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLL 816

Query: 3423 ENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENG---TW-TSPPICRAV 3471
               +   V+ Q G  + + C  G+ L+G   S C+  G    W +S P+C  +
Sbjct: 817  NGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQI 869



 Score =  282 bits (721), Expect = 5e-75
 Identities = 249/923 (26%), Positives = 363/923 (39%), Gaps = 139/923 (15%)

Query: 2670 THSSNFLYGTMVSYTCNPGYELLGNPV-LICQEDGTWNGSAPSCISIECDLPTAPENGFL 2728
            T    F  GT ++Y C PGY   G P  +IC ++  W G+   C    C  P  P NG +
Sbjct: 58   TDEFEFPIGTYLNYECRPGYS--GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMV 115

Query: 2729 RFTE-TSMGSAVQYSCKPGHILAGSDLRLCL---ENRKWSGASPRCEAISCKKPNPVMNG 2784
               +    GS ++YSC  G+ L GS    C+   +   W   +P C+ I C  P  + NG
Sbjct: 116  HVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNG 175

Query: 2785 ---SIKGSNYTYLSTLYYECDPG------YVLNGTERRTCQDDKN----WDEDEPICIPV 2831
               S    N+ Y S + Y C+PG      + L G     C  + +    W    P CI  
Sbjct: 176  DFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 235

Query: 2832 DCSSPPVSANGQVRGDE---YTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVP 2888
            +  +PP   NG +  D    ++  + +E+ C  GF+++G R   C A   W    P C  
Sbjct: 236  NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR 295

Query: 2889 VRCATPPQLANGVTEGLD---YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCK 2945
            V C  PP + +      D   +   +EV + C  GY L GA  + C   G+W    P C+
Sbjct: 296  V-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE 354

Query: 2946 PVNCGPPEDLAHGFPNG-----FSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGS---WSG 2997
              +C   +D      NG      +   G  + + C  G++L G+S+  C+  G    W+ 
Sbjct: 355  VKSC---DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 411

Query: 2998 SSPSCLPCRC-STPVIEYGTVNGTD---FDCGKAARIQCFK------GFKLLGLSEITCE 3047
            S P C    C S PVI  G   G     F  GK     C         F L+G S I C 
Sbjct: 412  SVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCT 471

Query: 3048 AD----GQWSSGFPHC---------EHTSCGSLPMIPNA--FISETSSWKENVITYSCRS 3092
            +D    G WSS  P C         +H     L    NA  F   TS      + Y CR 
Sbjct: 472  SDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTS------LKYECRP 525

Query: 3093 GYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYE-----SEVKLR 3147
             Y  +  S + C +  VWS P  VC+  SC +PP   N    G  H        S +   
Sbjct: 526  EYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKTPPDPVN----GMVHVITDIQVGSRINYS 580

Query: 3148 CLEGYTM--DTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQ--- 3202
            C  G+ +   +  +         W  +   C    C LP  I +    GD  S NR+   
Sbjct: 581  CTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIAN----GDFISTNRENFH 636

Query: 3203 ----VSVSCAEG------YTFEGVNISVCQLD----GTWEPPFSDESCSPVSCGKPESPE 3248
                V+  C  G      +   G     C  +    G W  P + +   P  C  P + E
Sbjct: 637  YGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP-APQCIIPNKC-TPPNVE 694

Query: 3249 HGFVVG---SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEF 3305
            +G +V    S ++    + ++C+PG+ ++G R   CQ   +W   +  C    C+ P + 
Sbjct: 695  NGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDV 753

Query: 3306 LNGKA---DIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFV 3362
            L+ +    D +N + G  V YSC  GY L G +   CT  G WS   P C+   C   F+
Sbjct: 754  LHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCD-DFM 812

Query: 3363 --IPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC---NPDETWTQTSAKCEKISCG 3417
              +    +L      +   V   C EGF L+G     C     +  W  +   CE+I C 
Sbjct: 813  GQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCP 872

Query: 3418 PPAHVENAIARGVH---YQYGDMITYSC------YSGYMLEGFLRSVCLE----NGTWTS 3464
             P  + N    G     + +G  + Y+C       + + L G     C      NG W+S
Sbjct: 873  SPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS 932

Query: 3465 P-PICRAVCRFPCQNGGICQRPN 3486
            P P C  +        G CQ P+
Sbjct: 933  PAPRCGIL--------GHCQAPD 947



 Score =  275 bits (704), Expect = 4e-73
 Identities = 241/914 (26%), Positives = 371/914 (40%), Gaps = 145/914 (15%)

Query: 1641 LRTASEDLKPGSKVNLFCDPG------FQLVGNPVQYCLNQ----GQWTQPLPHCERISC 1690
            + T  E+   GS V   C+ G      F+LVG P  YC +     G W+ P P C   + 
Sbjct: 1528 ISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1587

Query: 1691 GVPPPLENGFHSADD---FYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDV- 1746
              PP +ENG   +D+   F     V ++C  G+ + G  R+ C     W    PSC  V 
Sbjct: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1647

Query: 1747 ---DECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGN--PENGHSS 1801
                E   G     H    +       SC P Y   G   A  + C   G+  PE    +
Sbjct: 1648 QPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRG---AASLHCTPQGDWSPEAPRCA 1704

Query: 1802 --------GEI----------YTVGAEVTFSCQEGYQLMGVTKITCLESGE---WNHLIP 1840
                    G++            +GA+V+F C EG++L G +   C+  G    WN+ +P
Sbjct: 1705 VKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVP 1764

Query: 1841 YCKAVSCGKPAIPENGCIEELA---FTFGSKVTYRCN----KGYT--LAGDKESSCLA-- 1889
             C+ + C  P    NG           +G +++Y C+    +G T  L G+    C +  
Sbjct: 1765 VCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDP 1824

Query: 1890 --NSSWSHSPPVCE----PVKCSSPEN---------INNGKYILSGLTYLSTASYSCDTG 1934
              N  WS   P CE       C +PE          IN+ ++ +      ++ +Y C  G
Sbjct: 1825 HGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVG-----TSLNYECRPG 1879

Query: 1935 YSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFT-FRNTVTYTCKEGY 1993
            Y  +  SI  C  + +W      C    CG PP   + ++  N  T F +TV Y+C EG+
Sbjct: 1880 YFGKMFSI-SCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGF 1938

Query: 1994 TLAGLDTIECLADGK---WSRSDQQCLAVSCDEPPIVDHASPETAHRLF---GDIAFYYC 2047
             L G  +  CL  G    W +    C  +SC+ PP + +    + +R     G +  Y C
Sbjct: 1939 RLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQC 1998

Query: 2048 SDG------YSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAK 2101
              G      + L     + C ++   V       PRCI+      P V  +I    +++ 
Sbjct: 1999 HTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSF 2058

Query: 2102 FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGS- 2160
            F    ++ F+C  GFV+  S  ++C   G+W P       +   C  PP I++G  + S 
Sbjct: 2059 FTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV---CQPPPEILHGEHTLSH 2115

Query: 2161 --NYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHT 2218
              N+S G  V YSC   + ++G     C   G WS   P C   SC +      G L H 
Sbjct: 2116 QDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDD----FLGQLPH- 2170

Query: 2219 TGRIF-------ESEVRYQCNPGYKSVGSPVFVCQA---NRHWHSESPLMCVPLDCGKPP 2268
             GR+         ++V + C+ G++  G     C        W+S  P+ C  + C  PP
Sbjct: 2171 -GRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPV-CEQIFCPNPP 2228

Query: 2269 PIQNGFMKGENF---EVGSKVQFFCNEG------YELVGDSSWTC----QKSGKWNKKSN 2315
             I NG   G  F     G ++ + C+        + L+G+SS  C    Q +G W+  + 
Sbjct: 2229 AILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPA- 2287

Query: 2316 PKC---MPAKCPEPPLLEN--------QLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCL 2364
            P+C   +PA CP PP ++N         L L  +T     +++ C  G++L G   + C 
Sbjct: 2288 PRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMT-----ISYICDPGYLLVGKGFIFCT 2342

Query: 2365 PSQQWNDSFPVCKIVLCTPPPLISFGVPIP---SSALHFGSTVKYSCVGGFFLRGNSTTL 2421
                W+     CK V C+ P L   G+          H+G  V   C  G+ L G+  + 
Sbjct: 2343 DQGIWSQLDHYCKEVNCSFP-LFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQ 2401

Query: 2422 CQPDGTWSSPLPEC 2435
            CQ D  W  PL +C
Sbjct: 2402 CQADDRWDPPLAKC 2415



 Score =  266 bits (679), Expect = 4e-70
 Identities = 210/773 (27%), Positives = 314/773 (40%), Gaps = 122/773 (15%)

Query: 1640 HLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISC----GVPPP 1695
            H  +  ++  PG +V   C+PG+ L G    +C  QG W+   P C   SC    G  P 
Sbjct: 1658 HTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPH 1717

Query: 1696 LENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSCLDV------ 1746
                F    +   G+ V++ C+ G+ L G S   C   G    WN   P C  +      
Sbjct: 1718 GRVLFPL--NLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPP 1775

Query: 1747 ------------DECAVGSDCS-------EHASCLNVDGSYICSCVPPYTGDG------K 1781
                         +   G + S       +     N+ G     C     G+G       
Sbjct: 1776 AILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAP 1835

Query: 1782 NCAEPIK---CKAP-----GNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESG 1833
             C   ++   CK P      +P    +  E + VG  + + C+ GY    +  I+CLE+ 
Sbjct: 1836 RCELSVRAGHCKTPEQFPFASPTIPINDFE-FPVGTSLNYECRPGY-FGKMFSISCLENL 1893

Query: 1834 EWNHLIPYCKAVSCGKPAIPENGCIEELAFT-FGSKVTYRCNKGYTLAGDKESSCLA--- 1889
             W+ +   C+  SCG P  P NG +     T FGS V Y CN+G+ L G   ++CL    
Sbjct: 1894 VWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGN 1953

Query: 1890 NSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYL---STASYSCDTG------YSLQGP 1940
            N +W    P+CE + C  P  I+NG +  +  T     +  +Y C TG      + L G 
Sbjct: 1954 NVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGE 2013

Query: 1941 SIIECTAS----GIWDRAPPACHLVFCGEPPAIKDAV-ITGNN--FTFRNTVTYTCKEGY 1993
              I CT+     G+W   PP C        P +++A+ + GN   FT    + + C+ G+
Sbjct: 2014 RSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGF 2073

Query: 1994 TLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHR---LFGDIAFYYCSDG 2050
             + G  T++C  +G+W      C  V C  PP + H     +H+     G   FY C   
Sbjct: 2074 VMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPS 2132

Query: 2051 YSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAK------FAA 2104
            Y L   + L C  QG W P    + PRC    C+         L  +   +         
Sbjct: 2133 YDLRGAASLHCTPQGDWSP----EAPRCTVKSCD-------DFLGQLPHGRVLLPLNLQL 2181

Query: 2105 GSVVSFKCMEGFVLNTSAKIECMRGGQ---WNPS-PMSIQCIPVRCGEPPSIMNGYASGS 2160
            G+ VSF C EGF L   +   C+  G    WN S P+   C  + C  PP+I+NG  +G+
Sbjct: 2182 GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPV---CEQIFCPNPPAILNGRHTGT 2238

Query: 2161 NYS---FGAMVAYSCN------KGFYIKGEKKSTC----EATGQWSSPIPTCH---PVSC 2204
             +    +G  ++Y+C+        F + GE    C    +  G WSSP P C    P +C
Sbjct: 2239 PFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAAC 2298

Query: 2205 GEPPKVENGFL--EHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPL 2262
              PPK++NG     H +  +    + Y C+PGY  VG     C     W S+    C  +
Sbjct: 2299 PHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIW-SQLDHYCKEV 2357

Query: 2263 DCGKPPPIQNGFMK----GENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWN 2311
            +C   P   NG  K     + +  G  V   C +GY L G     CQ   +W+
Sbjct: 2358 NCSF-PLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWD 2409



 Score =  159 bits (401), Expect = 6e-38
 Identities = 118/393 (30%), Positives = 164/393 (41%), Gaps = 68/393 (17%)

Query: 1658 CDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSA---DDFYAGSTVTY 1714
            C PGF +VG+    C   G+W   LPHC R+ C  PP + +G H+    D+F  G  V Y
Sbjct: 2069 CQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFY 2127

Query: 1715 QCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVP 1774
             C   Y L G + + CT  G W+  +P C  V  C        H   L            
Sbjct: 2128 SCEPSYDLRGAASLHCTPQGDWSPEAPRCT-VKSCDDFLGQLPHGRVL------------ 2174

Query: 1775 PYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGE 1834
                             P N +          +GA+V+F C EG++L G +   C+ +G 
Sbjct: 2175 ----------------LPLNLQ----------LGAKVSFVCDEGFRLKGRSASHCVLAGM 2208

Query: 1835 ---WNHLIPYCKAVSCGKPAIPENGCIEELAF---TFGSKVTYRCN----KGYT--LAGD 1882
               WN  +P C+ + C  P    NG      F    +G +++Y C+    +G T  L G+
Sbjct: 2209 KALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGE 2268

Query: 1883 KESSCLA----NSSWSHSPPVCE---PVKCSSPENINNGKYILSGLT-YLS--TASYSCD 1932
                C +    N  WS   P CE   P  C  P  I NG YI   ++ YL   T SY CD
Sbjct: 2269 SSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICD 2328

Query: 1933 TGYSLQGPSIIECTASGIWDRAPPACHLVFCGEP---PAIKDAVITGNNFTFRNTVTYTC 1989
             GY L G   I CT  GIW +    C  V C  P     I   +     + + + VT  C
Sbjct: 2329 PGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKC 2388

Query: 1990 KEGYTLAGLDTIECLADGKWSRSDQQCLAVSCD 2022
            ++GYTL G    +C AD +W     +C + + D
Sbjct: 2389 EDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHD 2421



 Score = 68.9 bits (167), Expect = 8e-11
 Identities = 48/167 (28%), Positives = 68/167 (40%), Gaps = 15/167 (8%)

Query: 405  RCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYK-TTCL 463
            RC PGF +VGS  + C  NG W     +C  R C    +  HG  + S ++         
Sbjct: 2068 RCQPGFVMVGSHTVQCQTNGRWGPKLPHCS-RVCQPPPEILHGEHTLSHQDNFSPGQEVF 2126

Query: 464  VACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTF--QMPKDVIISPHNCGKQPAKF 521
             +C+  Y L G+  L C     W    PRC  + C  F  Q+P   ++ P N      + 
Sbjct: 2127 YSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLN-----LQL 2181

Query: 522  GTICYVSCRQGFILSGVKEMLRCTTSGK---WNVGVQAAVCKDVEAP 565
            G      C +GF L G +    C  +G    WN  V   VC+ +  P
Sbjct: 2182 GAKVSFVCDEGFRLKG-RSASHCVLAGMKALWNSSV--PVCEQIFCP 2225



 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 63/225 (28%), Positives = 90/225 (40%), Gaps = 43/225 (19%)

Query: 362 CREGYRASGQT-------------------CELVHCPALKPPENGYFIQ-NTCNNHFNAA 401
           C +GYR  G +                   C+ + C       NG FI  N  N H+ + 
Sbjct: 131 CTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSV 190

Query: 402 CGVRCHPG------FDLVGSSIILCLPN----GLWSGSESYCRVRTCPHLRQPKH--GHI 449
              RC+PG      F+LVG   I C  N    G+WSG    C +   P+   P +    I
Sbjct: 191 VTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII---PNKCTPPNVENGI 247

Query: 450 SCSTREMLYKTTCLVA--CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDV 507
             S    L+    +V   C  G+ ++G  ++ CQ  ++W+   P C  R C   Q P DV
Sbjct: 248 LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC-SRVC---QPPPDV 303

Query: 508 IISPH-NCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
           + +      K     G   + SC  G+ L G   M RCT  G W+
Sbjct: 304 LHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM-RCTPQGDWS 347



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 58/195 (29%), Positives = 83/195 (42%), Gaps = 24/195 (12%)

Query: 373 CELVHCPALKPPENGYFIQ-NTCNNHFNAACGVRCHPG------FDLVGSSIILCLPN-- 423
           C+ + C       NG FI  N  N H+ +    RC+PG      F+LVG   I C  N  
Sbjct: 611 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 670

Query: 424 --GLWSGSESYCRVRTCPHLRQPKH--GHISCSTREMLYKTTCLVA--CDEGYRLEGSDK 477
             G+WSG    C +   P+   P +    I  S    L+    +V   C  G+ ++G  +
Sbjct: 671 QVGIWSGPAPQCII---PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 727

Query: 478 LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKFGTICYVSCRQGFILS 536
           + CQ  ++W+   P C  R C   Q P DV+ +      K     G   + SC  G+ L 
Sbjct: 728 VKCQALNKWEPELPSC-SRVC---QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 783

Query: 537 GVKEMLRCTTSGKWN 551
           G   M RCT  G W+
Sbjct: 784 GAASM-RCTPQGDWS 797



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 58/195 (29%), Positives = 83/195 (42%), Gaps = 24/195 (12%)

Query: 373  CELVHCPALKPPENGYFIQ-NTCNNHFNAACGVRCHPG------FDLVGSSIILCLPN-- 423
            C+ + C       NG FI  N  N H+ +    RC+PG      F+LVG   I C  N  
Sbjct: 1061 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 1120

Query: 424  --GLWSGSESYCRVRTCPHLRQPKH--GHISCSTREMLYKTTCLVA--CDEGYRLEGSDK 477
              G+WSG    C +   P+   P +    I  S    L+    +V   C  G+ ++G  +
Sbjct: 1121 QVGIWSGPAPQCII---PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1177

Query: 478  LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKFGTICYVSCRQGFILS 536
            + CQ  ++W+   P C  R C   Q P DV+ +      K     G   + SC  G+ L 
Sbjct: 1178 VKCQALNKWEPELPSC-SRVC---QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 1233

Query: 537  GVKEMLRCTTSGKWN 551
            G   M RCT  G W+
Sbjct: 1234 GAASM-RCTPQGDWS 1247



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 110/437 (25%), Positives = 161/437 (36%), Gaps = 81/437 (18%)

Query: 374  ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428
            EL  C  + +PP      ++T ++  N + G      C PG+DL G++ + C P G WS 
Sbjct: 1639 ELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSP 1698

Query: 429  SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484
                C V++C   L Q  HG +       L      V CDEG+RL+GS    C      S
Sbjct: 1699 EAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFV-CDEGFRLKGSSVSHCVLVGMRS 1757

Query: 485  QWDGPEPRCVERHCSTFQMPKDVIISPHN---CGKQP--AKFGTICYVSCRQGFILSGVK 539
             W+   P C    C     P  ++   H     G  P   +    C     +G   + + 
Sbjct: 1758 LWNNSVPVCEHIFCPN---PPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIG 1814

Query: 540  E-MLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEA---KTLEQQDSANVTWQIPTAKD 595
            E  +RCT+    N GV +       +P   C   + A   KT EQ   A+ T  I   + 
Sbjct: 1815 ESTIRCTSDPHGN-GVWS-------SPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEF 1866

Query: 596  NSGEKVSVHVHPAFTPPYLFPIGDVA-IVYTATDLSGNQASCIFHIKVIDAEPPVIDWCR 654
              G  ++    P +    +F I  +  +V+++ + +  + SC                  
Sbjct: 1867 PVGTSLNYECRPGYFGK-MFSISCLENLVWSSVEDNCRRKSC------------------ 1907

Query: 655  SPPPVQVSEKVHAAS----WDEPQFSDNSGAELVITRSHTQGDLFPQGETIVQYTATDPS 710
             PPP   +  VH  +         +S N G  L+ + S                T    S
Sbjct: 1908 GPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPS----------------TTCLVS 1951

Query: 711  GNNRTCDIHI-VIKGSPCEIPFTPVNGDFIC---TPDNTGVNCTLTCLEGYD----FTEG 762
            GNN T D    + +   CE P T  NGDF     T  + G   T  C  G D    F   
Sbjct: 1952 GNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELV 2011

Query: 763  STDKYYCAYED---GVW 776
                 YC  +D   GVW
Sbjct: 2012 GERSIYCTSKDDQVGVW 2028



 Score = 63.5 bits (153), Expect = 3e-09
 Identities = 54/195 (27%), Positives = 74/195 (37%), Gaps = 31/195 (15%)

Query: 312  YGKGLQYECTACPSG--TYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRAS 369
            YGK + Y C   P    T+   G      S I C     TS P             + + 
Sbjct: 2245 YGKEISYACDTHPDRGMTFNLIGE-----SSIRC-----TSDPQGNGV--------WSSP 2286

Query: 370  GQTCEL---VHCPALKPPENGYFIQNTCNNHF-NAACGVRCHPGFDLVGSSIILCLPNGL 425
               CEL     CP     +NG++I    + +         C PG+ LVG   I C   G+
Sbjct: 2287 APRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGI 2346

Query: 426  WSGSESYCRVRTCPHLRQPKHGHISCSTREML----YKTTCLVACDEGYRLEGSDKLTCQ 481
            WS  + YC+   C     P   +      EM     Y     + C++GY LEGS    CQ
Sbjct: 2347 WSQLDHYCKEVNCSF---PLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQ 2403

Query: 482  GNSQWDGPEPRCVER 496
             + +WD P  +C  R
Sbjct: 2404 ADDRWDPPLAKCTSR 2418



 Score = 63.2 bits (152), Expect = 5e-09
 Identities = 55/195 (28%), Positives = 81/195 (41%), Gaps = 24/195 (12%)

Query: 373  CELVHCPALKPPENGYFIQ-NTCNNHFNAACGVRCHPG------FDLVGSSIILCLPN-- 423
            C+ + C       NG FI  N  N H+ +    RC+ G      F+LVG   I C  N  
Sbjct: 1511 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDD 1570

Query: 424  --GLWSGSESYCRVRTCPHLRQPKH--GHISCSTREMLYKTTCLVA--CDEGYRLEGSDK 477
              G+WSG    C +   P+   P +    I  S    L+    +V   C  G+ ++G  +
Sbjct: 1571 QVGIWSGPAPQCII---PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1627

Query: 478  LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQP-AKFGTICYVSCRQGFILS 536
            + CQ  ++W+   P C  R C   Q P +++   H    Q     G   + SC  G+ L 
Sbjct: 1628 VKCQALNKWEPELPSC-SRVC---QPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLR 1683

Query: 537  GVKEMLRCTTSGKWN 551
            G    L CT  G W+
Sbjct: 1684 GAAS-LHCTPQGDWS 1697



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 55/226 (24%), Positives = 85/226 (37%), Gaps = 24/226 (10%)

Query: 373  CELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNG---LWSGS 429
            C    C     P NG    NT +  F +     C+ GF L+GS    CL +G    W   
Sbjct: 1902 CRRKSCGPPPEPFNGMVHINT-DTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKK 1960

Query: 430  ESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLV-ACDEG------YRLEGSDKLTCQG 482
               C + +C       +G    + R   +  T +   C  G      + L G   + C  
Sbjct: 1961 APICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTS 2020

Query: 483  NSQ----WDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGV 538
                   W  P PRC+  +  T    ++ I  P N  +       I    C+ GF++ G 
Sbjct: 2021 KDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGN--RSFFTLTEIIRFRCQPGFVMVG- 2077

Query: 539  KEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAK-TLEQQDS 583
               ++C T+G+W  G +   C  V  P    P+ +  + TL  QD+
Sbjct: 2078 SHTVQCQTNGRW--GPKLPHCSRVCQPP---PEILHGEHTLSHQDN 2118



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 72/289 (24%), Positives = 98/289 (33%), Gaps = 52/289 (17%)

Query: 307  CEKGYYGKGL-QYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGST---------S 356
            CE  Y  +G     CT  P G + PE     + SC    D     P G           +
Sbjct: 2129 CEPSYDLRGAASLHCT--PQGDWSPEAPRCTVKSC---DDFLGQLPHGRVLLPLNLQLGA 2183

Query: 357  PEDCVCREGYRASGQT-------------------CELVHCPALKPPENGY-----FIQN 392
                VC EG+R  G++                   CE + CP      NG      F   
Sbjct: 2184 KVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDI 2243

Query: 393  TCNNHFNAACGVRCHPG--FDLVGSSIILCLP----NGLWSGSESYCRVRT---CPHLRQ 443
                  + AC      G  F+L+G S I C      NG+WS     C +     CPH  +
Sbjct: 2244 PYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPK 2303

Query: 444  PKHGH-ISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQ 502
             ++GH I       L   T    CD GY L G   + C     W   +  C E +CS   
Sbjct: 2304 IQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPL 2363

Query: 503  MPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
                  IS     K+   +G    + C  G+ L G     +C    +W+
Sbjct: 2364 FMNG--ISKELEMKKVYHYGDYVTLKCEDGYTLEG-SPWSQCQADDRWD 2409



 Score = 55.5 bits (132), Expect = 1e-06
 Identities = 39/134 (29%), Positives = 59/134 (44%), Gaps = 10/134 (7%)

Query: 374  ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428
            +L HC  + +PP      ++T ++  N + G      C P +DL G++ + C P G WS 
Sbjct: 2092 KLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSP 2151

Query: 429  SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484
                C V++C   L Q  HG +       L      V CDEG+RL+G     C      +
Sbjct: 2152 EAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFV-CDEGFRLKGRSASHCVLAGMKA 2210

Query: 485  QWDGPEPRCVERHC 498
             W+   P C +  C
Sbjct: 2211 LWNSSVPVCEQIFC 2224



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 53/195 (27%), Positives = 83/195 (42%), Gaps = 23/195 (11%)

Query: 374 ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428
           EL  C  + +PP +    + T  +  N + G      C PG+DL G++ + C P G WS 
Sbjct: 289 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 348

Query: 429 SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484
           +   C V++C   + Q  +G +       L      V CDEG++L+GS    C      S
Sbjct: 349 AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV-CDEGFQLKGSSASYCVLAGMES 407

Query: 485 QWDGPEPRCVERHCSTFQMPKDVIISPHNCGK--QPAKFGTICYVSC------RQGFILS 536
            W+   P C +  C +      VI +  + GK  +   FG     +C         F L 
Sbjct: 408 LWNSSVPVCEQIFCPS----PPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463

Query: 537 GVKEMLRCTTSGKWN 551
           G +  +RCT+  + N
Sbjct: 464 G-ESTIRCTSDPQGN 477



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 53/195 (27%), Positives = 83/195 (42%), Gaps = 23/195 (11%)

Query: 374 ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428
           EL  C  + +PP +    + T  +  N + G      C PG+DL G++ + C P G WS 
Sbjct: 739 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 798

Query: 429 SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484
           +   C V++C   + Q  +G +       L      V CDEG++L+GS    C      S
Sbjct: 799 AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV-CDEGFQLKGSSASYCVLAGMES 857

Query: 485 QWDGPEPRCVERHCSTFQMPKDVIISPHNCGK--QPAKFGTICYVSC------RQGFILS 536
            W+   P C +  C +      VI +  + GK  +   FG     +C         F L 
Sbjct: 858 LWNSSVPVCEQIFCPS----PPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 913

Query: 537 GVKEMLRCTTSGKWN 551
           G +  +RCT+  + N
Sbjct: 914 G-ESTIRCTSDPQGN 927



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 53/195 (27%), Positives = 83/195 (42%), Gaps = 23/195 (11%)

Query: 374  ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428
            EL  C  + +PP +    + T  +  N + G      C PG+DL G++ + C P G WS 
Sbjct: 1189 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 1248

Query: 429  SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484
            +   C V++C   + Q  +G +       L      V CDEG++L+GS    C      S
Sbjct: 1249 AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFV-CDEGFQLKGSSASYCVLAGMES 1307

Query: 485  QWDGPEPRCVERHCSTFQMPKDVIISPHNCGK--QPAKFGTICYVSC------RQGFILS 536
             W+   P C +  C +      VI +  + GK  +   FG     +C         F L 
Sbjct: 1308 LWNSSVPVCEQIFCPS----PPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLI 1363

Query: 537  GVKEMLRCTTSGKWN 551
            G +  +RCT+  + N
Sbjct: 1364 G-ESTIRCTSDPQGN 1377



 Score = 52.8 bits (125), Expect = 6e-06
 Identities = 44/177 (24%), Positives = 75/177 (42%), Gaps = 13/177 (7%)

Query: 406 CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA 465
           C PG+     SII CL N +W+G++  CR ++C +   P +G +    + + + +    +
Sbjct: 73  CRPGYSGRPFSII-CLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHV-IKGIQFGSQIKYS 130

Query: 466 CDEGYRLEGSDKLTC--QGNSQ-WDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKF 521
           C +GYRL GS   TC   G++  WD   P C    C    +P  +      +  ++   +
Sbjct: 131 CTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCG---LPPTITNGDFISTNRENFHY 187

Query: 522 GTICYVSCRQGF----ILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIE 574
           G++    C  G     +   V E     TS    VG+ +        P    P ++E
Sbjct: 188 GSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVE 244



 Score = 46.2 bits (108), Expect = 6e-04
 Identities = 60/231 (25%), Positives = 78/231 (33%), Gaps = 42/231 (18%)

Query: 307 CEKGYYGKG-LQYECTACPSGTYKPEGSPGGISSCIPCPDENHTS----PPGSTSPEDCV 361
           C+ G+  KG  + +C A     ++PE  P     C P PD  H         + SP   V
Sbjct: 266 CQPGFVMKGPRRVKCQAL--NKWEPE-LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEV 322

Query: 362 ---CREGYRASGQ----------------TCELVHCPALKPPENGYFIQNTCNNHFNAAC 402
              C  GY   G                 TCE+  C           +    N    A  
Sbjct: 323 FYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKV 382

Query: 403 GVRCHPGFDLVGSSIILCLPNG---LWSGSESYCRVRTCPHLRQPKHGHISCSTREML-Y 458
              C  GF L GSS   C+  G   LW+ S   C    CP      +G  +    E+  +
Sbjct: 383 DFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPF 442

Query: 459 KTTCLVACDE------GYRLEGSDKLTC----QGNSQWDGPEPRC-VERHC 498
             T    CD        + L G   + C    QGN  W  P PRC +  HC
Sbjct: 443 GKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 493



 Score = 46.2 bits (108), Expect = 6e-04
 Identities = 60/231 (25%), Positives = 78/231 (33%), Gaps = 42/231 (18%)

Query: 307 CEKGYYGKG-LQYECTACPSGTYKPEGSPGGISSCIPCPDENHTS----PPGSTSPEDCV 361
           C+ G+  KG  + +C A     ++PE  P     C P PD  H         + SP   V
Sbjct: 716 CQPGFVMKGPRRVKCQAL--NKWEPE-LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEV 772

Query: 362 ---CREGYRASGQ----------------TCELVHCPALKPPENGYFIQNTCNNHFNAAC 402
              C  GY   G                 TCE+  C           +    N    A  
Sbjct: 773 FYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKV 832

Query: 403 GVRCHPGFDLVGSSIILCLPNG---LWSGSESYCRVRTCPHLRQPKHGHISCSTREML-Y 458
              C  GF L GSS   C+  G   LW+ S   C    CP      +G  +    E+  +
Sbjct: 833 DFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPF 892

Query: 459 KTTCLVACDE------GYRLEGSDKLTC----QGNSQWDGPEPRC-VERHC 498
             T    CD        + L G   + C    QGN  W  P PRC +  HC
Sbjct: 893 GKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 943



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 61/231 (26%), Positives = 78/231 (33%), Gaps = 42/231 (18%)

Query: 307  CEKGYYGKG-LQYECTACPSGTYKPEGSPGGISSCIPCPDENHTS----PPGSTSPEDCV 361
            C+ G+  KG  + +C A     ++PE  P     C P PD  H         + SP   V
Sbjct: 1166 CQPGFVMKGPRRVKCQAL--NKWEPE-LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEV 1222

Query: 362  ---CREGYRASGQ----------------TCELVHCPALKPPENGYFIQNTCNNHFNAAC 402
               C  GY   G                 TCE+  C           +    N    A  
Sbjct: 1223 FYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKV 1282

Query: 403  GVRCHPGFDLVGSSIILCLPNG---LWSGSESYCRVRTCPHLRQPKHGHISCSTREML-- 457
               C  GF L GSS   C+  G   LW+ S   C    CP      +G  +    E+   
Sbjct: 1283 DFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPF 1342

Query: 458  ---YKTTCLVACDEG--YRLEGSDKLTC----QGNSQWDGPEPRC-VERHC 498
                  TC    D G  + L G   + C    QGN  W  P PRC +  HC
Sbjct: 1343 GKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHC 1393



 Score = 43.1 bits (100), Expect = 0.005
 Identities = 55/236 (23%), Positives = 77/236 (32%), Gaps = 47/236 (19%)

Query: 307  CEKGYYGKGL-QYECTACPSGTYKPEGSPGGISSCIPCPDE---NHTSPPGST---SPED 359
            CE GY  +G     CT  P G + P      + SC     +        P +    +  D
Sbjct: 1226 CEPGYDLRGAASMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVD 1283

Query: 360  CVCREGYRASGQT-------------------CELVHCPALKPPENGYFIQNTCNNH-FN 399
             VC EG++  G +                   CE + CP+     NG           F 
Sbjct: 1284 FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFG 1343

Query: 400  AACGVRCHP------GFDLVGSSIILCLP----NGLWSGSESYCRVRTCPHLRQPKHGHI 449
             A    C P       FDL+G S I C      NG+WS     C +    H + P H   
Sbjct: 1344 KAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI--LGHCQAPDHFLF 1401

Query: 450  S-----CSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCST 500
            +      +  +    T+    C   Y       +TC  N  W  P+  C  + C T
Sbjct: 1402 AKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCKT 1456



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 36/165 (21%), Positives = 62/165 (37%), Gaps = 12/165 (7%)

Query: 418 ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477
           I CL N +WS  +  C+ ++C     P +G +   T ++   +    +C  G+RL G   
Sbjct: 534 ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGSRINYSCTTGHRLIGHSS 592

Query: 478 LTC--QGN-SQWDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKFGTICYVSCRQGF 533
             C   GN + W    P C    C    +P  +      +  ++   +G++    C  G 
Sbjct: 593 AECILSGNAAHWSTKPPICQRIPCG---LPPTIANGDFISTNRENFHYGSVVTYRCNPGS 649

Query: 534 ----ILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIE 574
               +   V E     TS    VG+ +        P    P ++E
Sbjct: 650 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVE 694



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 36/165 (21%), Positives = 62/165 (37%), Gaps = 12/165 (7%)

Query: 418  ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477
            I CL N +WS  +  C+ ++C     P +G +   T ++   +    +C  G+RL G   
Sbjct: 984  ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGSRINYSCTTGHRLIGHSS 1042

Query: 478  LTC--QGN-SQWDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKFGTICYVSCRQGF 533
              C   GN + W    P C    C    +P  +      +  ++   +G++    C  G 
Sbjct: 1043 AECILSGNAAHWSTKPPICQRIPCG---LPPTIANGDFISTNRENFHYGSVVTYRCNPGS 1099

Query: 534  ----ILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIE 574
                +   V E     TS    VG+ +        P    P ++E
Sbjct: 1100 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVE 1144



 Score = 36.6 bits (83), Expect = 0.46
 Identities = 23/84 (27%), Positives = 36/84 (42%), Gaps = 4/84 (4%)

Query: 418  ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477
            I CL N +WS  +  C+ ++C     P +G +   T ++   +    +C  G+RL G   
Sbjct: 1434 ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGSRINYSCTTGHRLIGHSS 1492

Query: 478  LTC--QGN-SQWDGPEPRCVERHC 498
              C   GN + W    P C    C
Sbjct: 1493 AECILSGNTAHWSTKPPICQRIPC 1516


>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
          Length = 3667

 Score =  521 bits (1341), Expect = e-147
 Identities = 391/1329 (29%), Positives = 559/1329 (42%), Gaps = 142/1329 (10%)

Query: 1789 CKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLE--SGEWNHLIPYCKAVS 1846
            C  P    NG   G  +TVG  ++F C  GY L+G + +TCL   S  WNH +P C+A+ 
Sbjct: 2184 CPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL- 2242

Query: 1847 CGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKC- 1905
            CG      NG I    +         C   + +     +    N +   + P+ + +   
Sbjct: 2243 CGGNITAMNGTIYSPGYPDEYPNFQDC--FWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2300

Query: 1906 SSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGE 1965
              P+  +      SG T L +  YS      ++  S  + T SG +  +  A  L  C  
Sbjct: 2301 DGPDQNSPQIGQFSGNTALESV-YSTSNQILIKFHS--DFTTSGFFVLSYHAYQLRVCQP 2357

Query: 1966 PPAIKDAVI--TGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDE 2023
            PP + +A I    + F   + + Y C  G+TL G   + C   G+  + D          
Sbjct: 2358 PPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRL-GERLQMD--------GA 2408

Query: 2024 PPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKW--VPPEGQDMPRCIAH 2081
            PP+     P    RL  D      S GY  +  +  +C     W     +G ++   +  
Sbjct: 2409 PPVCQVLCPANELRL--DSTGVILSPGYPDSYPNLQMC----AWSISVEKGYNITMFVEF 2462

Query: 2082 F-CEKP---------PSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQ 2131
            F  EK          P++   +L S+S    +A ++ S    E F+             Q
Sbjct: 2463 FQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITS-NGHEVFL-------------Q 2508

Query: 2132 W------NPSPMSIQCIPVRCGEPPSIMNGY-ASGSNYSFGAMVAYSCNKGFYIKGEKKS 2184
            W      N     I+ I   C  P S  +GY  S +     ++V ++C++GF + G+  +
Sbjct: 2509 WSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSA 2568

Query: 2185 TCEATG----QWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYK--SV 2238
             C  +      W +P+P C  +SCG P    NG +  TT  +  + V Y CN GY+  S 
Sbjct: 2569 VCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGI-LTTDYLVGTRVTYFCNDGYRLSSK 2627

Query: 2239 GSPVFVCQANRHW--HSESPLMCVPLDCGKPPPIQNGF---------MKGENFEVGSKVQ 2287
                 VCQ++  W  H+++P  CV + C    P  N F         + G ++E  +KV 
Sbjct: 2628 ELTTAVCQSDGTWSNHNKTP-RCVVVTC----PSINSFILEHGRWRIVNGSHYEYKTKVV 2682

Query: 2288 FFCNEGYELVGDSSWTCQKSGKWN-KKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVT 2346
            F C+ GY  +G +S  C  +G W+ +   P C    C E P   N   +   T+      
Sbjct: 2683 FSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAI 2742

Query: 2347 FSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKY 2406
            F+C  G +L G +V +CL S  W++S   C    C  P LI  G  I  +   +  TV Y
Sbjct: 2743 FTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGEN-YGYRDTVVY 2801

Query: 2407 SCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTC 2466
             C  GF L G+S  +CQ D  WS  LP CVPV C  P     G     G  +     ++C
Sbjct: 2802 QCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSC 2861

Query: 2467 KPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILN----GKFSYTDLHYGQTVTY 2522
              G+ + G T   C  N  W    P CK + C  P    N     K  + +  YG  V Y
Sbjct: 2862 NIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFY 2921

Query: 2523 SCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSC 2582
             CN G+ L G S L C   G WD   P C  I C  P    N  + G  Y++G+ + YSC
Sbjct: 2922 DCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSC 2981

Query: 2583 FPGFQVAGHAMQTCEESG-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMM 2641
                 + G + +TC+ +G WS S P C             GD T    D G         
Sbjct: 2982 TGKRSLLGQSSRTCQLNGHWSGSQPHCS------------GDATGTCGDPG--------- 3020

Query: 2642 EVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQE 2701
                                  T    +   SNF   + V Y C+ GY L G+    C  
Sbjct: 3021 ----------------------TPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLA 3058

Query: 2702 DGTWNGSAPSCISIECDLPTAPENG-FLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN 2760
            +G+W G  P C +++C  P    NG   R   T+  S+V YSC  G+IL+G  +R C  N
Sbjct: 3059 NGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTAN 3118

Query: 2761 RKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYV--LNGTERRTCQDD 2818
              WSG  P C  ISC  P    NG   G +Y     + Y C PGY   LNG+  RTC  +
Sbjct: 3119 GTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN 3178

Query: 2819 KNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGS 2878
              W    P C  V C +PP  +NG++ G  + +   I Y C+ G+ L       C+ NG+
Sbjct: 3179 GTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT 3238

Query: 2879 WSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWD 2938
            WSG  P C+P  C  P   A G  EG  + +  EV+F C+  +IL G+    CQ+DG W 
Sbjct: 3239 WSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWS 3298

Query: 2939 AEIPLC---KPVNCGPPEDLAHGFPNG-FSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGS 2994
               P C      +C  P    HG  N  F F  G  +Q+ C  G+ L G+++R CL + +
Sbjct: 3299 GSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLT 3358

Query: 2995 WSGSSPSCLPCRCSTP-VIEYGTVNGTDFDC-GKAARIQCFKGFKLLGLSE-ITCEADGQ 3051
            WSG  P C+P  C  P    +  V G D    G      C  GF L G +E   C +D  
Sbjct: 3359 WSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT 3418

Query: 3052 WSSGFPHCE 3060
            W+   P CE
Sbjct: 3419 WTGKVPICE 3427



 Score =  494 bits (1271), Expect = e-139
 Identities = 335/1075 (31%), Positives = 480/1075 (44%), Gaps = 119/1075 (11%)

Query: 2204 CGEPPKVENGFL-----EHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSE-SPL 2257
            C  PP V N  +     E   G I    +RYQC PG+  VG+ +  C+       + +P 
Sbjct: 2355 CQPPPPVPNAEILTEDDEFEIGDI----IRYQCLPGFTLVGNAILTCRLGERLQMDGAPP 2410

Query: 2258 MC---------------VPLDCGKPPPIQNGFMKG------ENFEVGSKVQFFCNEG--- 2293
            +C               V L  G P    N  M        + + +   V+FF  E    
Sbjct: 2411 VCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFD 2470

Query: 2294 ---------------YELVGD--SSWTCQKSG-----KW------NKKS-NPKCMPAKCP 2324
                             L GD  S++    +G     +W      NKK    + +   C 
Sbjct: 2471 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2530

Query: 2325 EPPLLENQLVLKELTTEVG-VVTFSCKEGHVLQGPSVLKCLPSQQ----WNDSFPVCKIV 2379
             P    +  ++ +   ++  VV ++C  G  L G S   C  S      W+   P C+ +
Sbjct: 2531 TPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAI 2590

Query: 2380 LCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGN--STTLCQPDGTWSS--PLPEC 2435
             C  P   + G  + +  L  G+ V Y C  G+ L     +T +CQ DGTWS+    P C
Sbjct: 2591 SCGIPKAPTNGGILTTDYL-VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRC 2649

Query: 2436 VPVECPQPEE--IPNG---IIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENG--HWLG 2488
            V V CP      + +G   I++     Y +  +++C PG+  +G  +  C  NG   W  
Sbjct: 2650 VVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRN 2709

Query: 2489 GKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDA 2548
             +P C+ I C +     NG    T   YG T  ++C+ GF L G +   CL +G W    
Sbjct: 2710 ERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESE 2769

Query: 2549 PSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEES-GWSSSIPT 2607
              C A HC  P+ I NG V G +Y Y   ++Y C PGF++ G +++ C++   WS  +P+
Sbjct: 2770 TRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPS 2829

Query: 2608 CMPIDCGLPPH----------IDFGDCTKLKDDQGYFEQEDD--MMEVPYVTPHPPYHLG 2655
            C+P+ CG P             +F D      + GY  Q       +      HPP    
Sbjct: 2830 CVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK 2889

Query: 2656 AVAKTWE----NTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPS 2711
             V  +      N+K        NF YGT+V Y CNPGY L G+ VLICQ +G W+   P 
Sbjct: 2890 VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPE 2949

Query: 2712 CISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCE 2771
            CI I+C  P  P N  L   + + GS V YSC     L G   R C  N  WSG+ P C 
Sbjct: 2950 CIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCS 3009

Query: 2772 AI---SCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPIC 2828
                 +C  P    +GS + SN+   ST+ Y CD GY+L+G+E RTC  + +W   +P C
Sbjct: 3010 GDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC 3069

Query: 2829 IPVDCSSPPVSANGQV-RGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCV 2887
              V C +P  +ANG+V R D  TF   + Y+C EG++L G   R C ANG+WSG  P+C 
Sbjct: 3070 KAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3129

Query: 2888 PVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYI--LHGAPKLTCQSDGNWDAEIPLCK 2945
             + C  P   ANG+  G DY   + V++ C  GY   L+G+   TC  +G W   +P C+
Sbjct: 3130 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR 3189

Query: 2946 PVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPC 3005
             V C  P  +++G   G +F  G  I Y C PGY+L   +   C+ NG+WSG  P CLP 
Sbjct: 3190 AVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPK 3249

Query: 3006 RCSTPVI-EYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHC---EH 3061
             C  P I   G   G  F         C   F L+G S   C+ADG WS   PHC     
Sbjct: 3250 FCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQ 3309

Query: 3062 TSCGSLPMIP------NAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYP 3115
            TSC + P +P      N F  +  S    V+ + C+ G+++QGS+   C     WS   P
Sbjct: 3310 TSCEN-PGVPRHGSQNNTFGFQVGS----VVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP 3364

Query: 3116 VCEPLSCGSPPSVANAVATG-EAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRW 3169
             C P SC  P + A+A   G +  ++   +   C  G+ +   T+   C+ D  W
Sbjct: 3365 ECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTW 3419



 Score =  458 bits (1178), Expect = e-128
 Identities = 327/1164 (28%), Positives = 486/1164 (41%), Gaps = 146/1164 (12%)

Query: 2372 SFPVCKIVLCTPPPLISFGVPIPSSAL-------HFGSTVKYSCVGGFFLRGNSTTLC-- 2422
            S+   ++ +C PPP      P+P++ +         G  ++Y C+ GF L GN+   C  
Sbjct: 2346 SYHAYQLRVCQPPP------PVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRL 2399

Query: 2423 ----QPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTT 2478
                Q DG      P    V CP  E              L +      PG+        
Sbjct: 2400 GERLQMDGA-----PPVCQVLCPANE------------LRLDSTGVILSPGYPDSYPNLQ 2442

Query: 2479 LCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTC 2538
            +C  +     G      +E  + ++    +F    ++ G  +          +  SA   
Sbjct: 2443 MCAWSISVEKGYNITMFVEFFQTEK----EFDVLQVYDGPNIQSPVLISLSGDYSSAFNI 2498

Query: 2539 LETG-----DWDVDAPSCN--------AIHCDSPQPIENGFV-EGADYSYGAIIIYSCFP 2584
               G      W  D  +          A +C +P+   +G++         +++ ++C  
Sbjct: 2499 TSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDR 2558

Query: 2585 GFQVAGHAMQTCEESG-----WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDD 2639
            GF++ G +   C +S      W + +P C  I CG+P                       
Sbjct: 2559 GFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPK---------------------- 2596

Query: 2640 MMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVL-- 2697
                       P + G +              ++++L GT V+Y CN GY L    +   
Sbjct: 2597 ----------APTNGGIL--------------TTDYLVGTRVTYFCNDGYRLSSKELTTA 2632

Query: 2698 ICQEDGTWNG--SAPSCISIECDLPTA--PENGFLRFTETS---MGSAVQYSCKPGHILA 2750
            +CQ DGTW+     P C+ + C    +   E+G  R    S     + V +SC PG+   
Sbjct: 2633 VCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGL 2692

Query: 2751 GSDLRLCLENRKWSGAS--PRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLN 2808
            G     CL N  WS  +  P C+ ISC +     NG+  G+  +Y ST  + CD G++L 
Sbjct: 2693 GPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLV 2752

Query: 2809 GTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGA 2868
            G+  R C     W E E  C+   C  P +  NGQV G+ Y ++  + Y CN GF L G+
Sbjct: 2753 GSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGS 2812

Query: 2869 RSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPK 2928
              R+C  + +WSG  P CVPV C  P     G T G  + F   VTF C+ GY++ G  K
Sbjct: 2813 SVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTK 2872

Query: 2929 LTCQSDGNWDAEIPLCKPVNCGPP---------EDLAHGFPNGFSFIHGGHIQYQCFPGY 2979
              CQ++  W    P+CK VNC  P           + HG     +F +G  + Y C PGY
Sbjct: 2873 AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHG-----NFTYGTVVFYDCNPGY 2927

Query: 2980 KLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTV-NGTDFDCGKAARIQCFKGFKL 3038
             L G+S   C  NG W    P C+   C  P +    V +G  +  G      C     L
Sbjct: 2928 FLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL 2987

Query: 3039 LGLSEITCEADGQWSSGFPHCEHTSCGSL--PMIPNAFISETSSWK-ENVITYSCRSGYV 3095
            LG S  TC+ +G WS   PHC   + G+   P  P     + S+++ ++ + Y+C +GY+
Sbjct: 2988 LGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYI 3047

Query: 3096 IQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANA-VATGEAHTYESEVKLRCLEGYTM 3154
            + GS +  C   G W+   P C+ + CG+P + AN  V   +  T+ S V   C+EGY +
Sbjct: 3048 LHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYIL 3107

Query: 3155 DTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFE 3214
             +      C  +G W     +C+   C  P    + L +GDD+ V + VS  C  GYT E
Sbjct: 3108 -SGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTME 3166

Query: 3215 --GVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYE 3272
              G  I  C ++GTW       +C  V+C  P    +G + G+ + +  +I Y C PGYE
Sbjct: 3167 LNGSRIRTCTINGTWSGVMP--TCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYE 3224

Query: 3273 LEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLE 3332
            L       C  N  WSG V  C    C  P     GK + ++      V +SCN  + L 
Sbjct: 3225 LSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILV 3284

Query: 3333 GPSEAHCTENGTWSHPVPLC---KPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFL 3389
            G S   C  +GTWS   P C       C  P V    +  +   F V   V   C++G L
Sbjct: 3285 GSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHL 3344

Query: 3390 LQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHY-QYGDMITYSCYSGYML 3448
            LQG    TC PD TW+    +C   SC  P    +A   G+    +G  + Y+C  G+ L
Sbjct: 3345 LQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFL 3404

Query: 3449 EGFL-RSVCLENGTWTSP-PICRA 3470
             G     VC  + TWT   PIC A
Sbjct: 3405 AGGTEHRVCRSDNTWTGKVPICEA 3428



 Score =  454 bits (1168), Expect = e-127
 Identities = 318/1171 (27%), Positives = 486/1171 (41%), Gaps = 162/1171 (13%)

Query: 1690 CGVPPPLENG--FHSADDFYAGSTVTYQCNNGYYLLGDSRMFCT--DNGSWNGVSPSC-- 1743
            C  PPP+ N       D+F  G  + YQC  G+ L+G++ + C   +    +G  P C  
Sbjct: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2414

Query: 1744 ------LDVDECAV---------GSDCSEHASCLNVDGSYICSCVPPY-----------T 1777
                  L +D   V           +    A  ++V+  Y  +    +            
Sbjct: 2415 LCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQV 2474

Query: 1778 GDGKNCAEPIKCKAPGN-------PENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCL 1830
             DG N   P+     G+         NGH   E++   +    + ++G+++  +      
Sbjct: 2475 YDGPNIQSPVLISLSGDYSSAFNITSNGH---EVFLQWSADHGNNKKGFRIRYI------ 2525

Query: 1831 ESGEWNHLIPYCKAVSCGKPAIPENG-CIEELAFTFGSKVTYRCNKGYTLAGDKESSCLA 1889
                         A  C  P  P +G  I +      S V + C++G+ L G   + C  
Sbjct: 2526 -------------AFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRK 2572

Query: 1890 NS----SWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIE- 1944
            +S    +W    P C+ + C  P+   NG  + +     +  +Y C+ GY L    +   
Sbjct: 2573 SSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTA 2632

Query: 1945 -CTASGIWD--RAPPACHLVFCGEPPAIKD--------AVITGNNFTFRNTVTYTCKEGY 1993
             C + G W      P C +V C   P+I           ++ G+++ ++  V ++C  GY
Sbjct: 2633 VCQSDGTWSNHNKTPRCVVVTC---PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGY 2689

Query: 1994 TLAGLDTIECLADGKWSRSDQQ--CLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGY 2051
               G  +IECL +G WS  +++  C  +SC E P   + +       +G  A + C  G+
Sbjct: 2690 HGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGF 2749

Query: 2052 SLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFK 2111
             L  ++   C + G W   E     RC+A  C  P  +   +   V    +     V ++
Sbjct: 2750 MLVGSAVRECLSSGLWSESE----TRCLAGHCGIPELI---VNGQVIGENYGYRDTVVYQ 2802

Query: 2112 CMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYS 2171
            C  GF L  S+   C +   W+    S  C+PV CG P S + G  SG+ ++F  +V +S
Sbjct: 2803 CNPGFRLIGSSVRICQQDHNWSGQLPS--CVPVSCGHPGSPIYGRTSGNGFNFNDVVTFS 2860

Query: 2172 CNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEP---------PKVENGFLEHTTGRI 2222
            CN G+ ++G  K+ C+A  QWS P P C  V+C +P          K+E+G   + T   
Sbjct: 2861 CNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGT--- 2917

Query: 2223 FESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEV 2282
                V Y CNPGY   GS V +CQ N  W    P  C+ +DCG P    N  + GE +  
Sbjct: 2918 ---VVFYDCNPGYFLFGSSVLICQPNGQWDKPLP-ECIMIDCGHPGVPPNAVLSGEKYTF 2973

Query: 2283 GSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKC---MPAKCPEPPLLENQLVLKELT 2339
            GS V + C     L+G SS TCQ +G W+  S P C       C +P    +    +   
Sbjct: 2974 GSTVHYSCTGKRSLLGQSSRTCQLNGHWS-GSQPHCSGDATGTCGDPGTPGHGSRQESNF 3032

Query: 2340 TEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALH 2399
                 V ++C  G++L G     CL +  W    P CK V C  P   + G         
Sbjct: 3033 RTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTT 3092

Query: 2400 FGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYL 2459
            F S+V YSC+ G+ L G S   C  +GTWS  LP C  + C  P    NG+         
Sbjct: 3093 FSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVG 3152

Query: 2460 STALYTCKPGF--ELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYG 2517
                Y C+PG+  EL G+    C  NG W G  PTC+A+ C  P +I NG+   T+  +G
Sbjct: 3153 QNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWG 3212

Query: 2518 QTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAI 2577
             +++Y C+ G+ L  P+ LTC+  G W  + P C    C  P     G  EG  + Y + 
Sbjct: 3213 FSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSE 3272

Query: 2578 IIYSCFPGFQVAGHAMQTCEESG-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQ 2636
            + +SC   F + G + + C+  G WS S P C+                         E 
Sbjct: 3273 VSFSCNFPFILVGSSTRICQADGTWSGSSPHCI-------------------------EP 3307

Query: 2637 EDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPV 2696
                 E P V  H                     ++  F  G++V + C  G+ L G+  
Sbjct: 3308 TQTSCENPGVPRH-----------------GSQNNTFGFQVGSVVQFHCKKGHLLQGSTT 3350

Query: 2697 LICQEDGTWNGSAPSCISIECDLPTAPEN-GFLRFTETSMGSAVQYSCKPGHILA-GSDL 2754
              C  D TW+G  P CI   C  P  P +   +     S G  + Y+C+PG  LA G++ 
Sbjct: 3351 RTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEH 3410

Query: 2755 RLCLENRKWSGASPRCEA---ISCKKPNPVM 2782
            R+C  +  W+G  P CEA   I  K P P +
Sbjct: 3411 RVCRSDNTWTGKVPICEAGSKILVKDPRPAL 3441



 Score =  437 bits (1123), Expect = e-121
 Identities = 285/926 (30%), Positives = 402/926 (43%), Gaps = 71/926 (7%)

Query: 1652 SKVNLFCDPGFQLVGNPVQYCLNQGQ----WTQPLPHCERISCGVPPPLENGFHSADDFY 1707
            S V   CD GF+LVG     C         W  P+P C+ ISCG+P    NG     D+ 
Sbjct: 2550 SVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYL 2609

Query: 1708 AGSTVTYQCNNGYYLLGD--SRMFCTDNGSWNG--VSPSCLDVDECAVGSDCSEHASCLN 1763
             G+ VTY CN+GY L     +   C  +G+W+    +P C+ V   ++ S   EH     
Sbjct: 2610 VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRI 2669

Query: 1764 VDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMG 1823
            V+GS+                                    Y    +V FSC  GY  +G
Sbjct: 2670 VNGSH------------------------------------YEYKTKVVFSCDPGYHGLG 2693

Query: 1824 VTKITCLESGEWN--HLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAG 1881
               I CL +G W+  +  PYC+ +SCG+   P NG       ++GS   + C+ G+ L G
Sbjct: 2694 PASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVG 2753

Query: 1882 DKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPS 1941
                 CL++  WS S   C    C  PE I NG+ I     Y  T  Y C+ G+ L G S
Sbjct: 2754 SAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSS 2813

Query: 1942 IIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTI 2001
            +  C     W    P+C  V CG P +      +GN F F + VT++C  GY + G    
Sbjct: 2814 VRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKA 2873

Query: 2002 ECLADGKWSRSDQQCLAVSCDEPPIVDHASPET----AHRLFGDIAFYYCSDGYSLADNS 2057
            +C A+ +WS     C  V+C +P I  ++  E+     +  +G + FY C+ GY L  +S
Sbjct: 2874 QCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSS 2933

Query: 2058 QLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFV 2117
             L+C   G+W  P    +P CI   C  P     ++L   S  K+  GS V + C     
Sbjct: 2934 VLICQPNGQWDKP----LPECIMIDCGHPGVPPNAVL---SGEKYTFGSTVHYSCTGKRS 2986

Query: 2118 LNTSAKIECMRGGQWNPS-PMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGF 2176
            L   +   C   G W+ S P         CG+P +  +G    SN+   + V Y+C+ G+
Sbjct: 2987 LLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGY 3046

Query: 2177 YIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYK 2236
             + G ++ TC A G W+   P C  V CG P    NG +    G  F S V Y C  GY 
Sbjct: 3047 ILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYI 3106

Query: 2237 SVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGY-- 2294
              G  V  C AN  W    P  C  + CG P    NG   G+++ VG  V + C  GY  
Sbjct: 3107 LSGPSVRQCTANGTWSGTLP-NCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTM 3165

Query: 2295 ELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGV-VTFSCKEGH 2353
            EL G    TC  +G W+    P C    CP PP + N   L+    + G  +++ C  G+
Sbjct: 3166 ELNGSRIRTCTINGTWSGVM-PTCRAVTCPTPPQISNGR-LEGTNFDWGFSISYICSPGY 3223

Query: 2354 VLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFF 2413
             L  P+VL C+ +  W+   P C    C  P + + G     S + + S V +SC   F 
Sbjct: 3224 ELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFI-YQSEVSFSCNFPFI 3282

Query: 2414 LRGNSTTLCQPDGTWSSPLPECV---PVECPQPEEIPNGI-IDVQGLAYLSTALYTCKPG 2469
            L G+ST +CQ DGTWS   P C+      C  P    +G   +  G    S   + CK G
Sbjct: 3283 LVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKG 3342

Query: 2470 FELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDL-HYGQTVTYSCNRGF 2528
              L G+TT  C  +  W G +P C    C +P+   +      DL  +G T+ Y+C  GF
Sbjct: 3343 HLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGF 3402

Query: 2529 RLEGPSA-LTCLETGDWDVDAPSCNA 2553
             L G +    C     W    P C A
Sbjct: 3403 FLAGGTEHRVCRSDNTWTGKVPICEA 3428



 Score =  379 bits (974), Expect = e-104
 Identities = 333/1226 (27%), Positives = 494/1226 (40%), Gaps = 154/1226 (12%)

Query: 2401 GSTVKYSCVGGFFLRGNSTTLCQP--DGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAY 2458
            G T+ + C  G+ L GNS   C       W+ PLP C  + C       NG I   G   
Sbjct: 2203 GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-CGGNITAMNGTIYSPGYPD 2261

Query: 2459 LSTALYTC------KPGFELVGNTTTLCGENGH-----WLGGKPTCKAIECLKPKEILNG 2507
                   C       PG  +  N T L  E  +     W G       I          G
Sbjct: 2262 EYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQI----------G 2311

Query: 2508 KFSYTDLHYGQTV---TYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIEN 2564
            +FS      G T     YS +    ++  S  T   +G + +   +     C  P P+ N
Sbjct: 2312 QFS------GNTALESVYSTSNQILIKFHSDFTT--SGFFVLSYHAYQLRVCQPPPPVPN 2363

Query: 2565 GFV--EGADYSYGAIIIYSCFPGFQVAGHAMQTC---EESGWSSSIPTCMPIDCGLPPHI 2619
              +  E  ++  G II Y C PGF + G+A+ TC   E      + P C  +    P + 
Sbjct: 2364 AEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVL---CPANE 2420

Query: 2620 DFGDCTKLKDDQGYFEQEDDMMEVPY-VTPHPPYHLGAVAKTWENTKESPATHSSNFLYG 2678
               D T +    GY +   ++    + ++    Y++    + ++  KE          + 
Sbjct: 2421 LRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----------FD 2470

Query: 2679 TMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSA 2738
             +  Y                  DG  N  +P  IS+  D  +A       F  TS G  
Sbjct: 2471 VLQVY------------------DGP-NIQSPVLISLSGDYSSA-------FNITSNGHE 2504

Query: 2739 V--QYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYL-S 2795
            V  Q+S   G+            N+K  G   R  A  C  P    +G I       L S
Sbjct: 2505 VFLQWSADHGN------------NKK--GFRIRYIAFYCSTPESPPHGYIISQTGGQLNS 2550

Query: 2796 TLYYECDPGYVLNGTERRTCQDDKN----WDEDEPICIPVDCSSPPVSANGQVRGDEYTF 2851
             + + CD G+ L G     C+        WD   P C  + C  P    NG +   +Y  
Sbjct: 2551 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLV 2610

Query: 2852 QKEIEYTCNEGFLLEGAR--SRVCLANGSWSG--ATPDCVPVRCATPPQ--LANG---VT 2902
               + Y CN+G+ L      + VC ++G+WS    TP CV V C +     L +G   + 
Sbjct: 2611 GTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIV 2670

Query: 2903 EGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWD--AEIPLCKPVNCGPPEDLAHGFP 2960
             G  Y +  +V F C  GY   G   + C  +G W    E P C+ ++CG      +G  
Sbjct: 2671 NGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNK 2730

Query: 2961 NGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTP-VIEYGTVNG 3019
             G    +G    + C  G+ L G++ R CLS+G WS S   CL   C  P +I  G V G
Sbjct: 2731 IGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIG 2790

Query: 3020 TDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETS 3079
             ++        QC  GF+L+G S   C+ D  WS   P C   SCG  P  P    +  +
Sbjct: 2791 ENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGH-PGSPIYGRTSGN 2849

Query: 3080 SWKEN-VITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAH 3138
             +  N V+T+SC  GY++QG +   C     WS P P+C+ ++C  P   AN+    +  
Sbjct: 2850 GFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIE 2909

Query: 3139 ----TYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHG 3194
                TY + V   C  GY +   +    CQ +G+W      C    C  P    + ++ G
Sbjct: 2910 HGNFTYGTVVFYDCNPGYFL-FGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSG 2968

Query: 3195 DDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTW---EPPFSDESCSPVSCGKPESPEHGF 3251
            + ++    V  SC    +  G +   CQL+G W   +P  S ++    +CG P +P HG 
Sbjct: 2969 EKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATG--TCGDPGTPGHGS 3026

Query: 3252 VVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKA- 3310
               S +  +ST+ Y C+ GY L G+ ER C  N  W+G    CK  +C  P    NGK  
Sbjct: 3027 RQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVF 3086

Query: 3311 DIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLS 3370
             I+  T   +V+YSC  GY L GPS   CT NGTWS  +P C    C  P  IP N L  
Sbjct: 3087 RIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPG-IPANGLRY 3145

Query: 3371 EKEFYVDQNVSIKCREGFLLQGHG--IITCNPDETWTQTSAKCEKISCGPPAHVENAIAR 3428
              ++ V QNVS  C+ G+ ++ +G  I TC  + TW+     C  ++C  P  + N    
Sbjct: 3146 GDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLE 3205

Query: 3429 GVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGI---CQRP 3485
            G ++ +G  I+Y C  GY L       C+ NGTW S  + + + +F C + GI    +R 
Sbjct: 3206 GTNFDWGFSISYICSPGYELSFPAVLTCVGNGTW-SGEVPQCLPKF-CGDPGIPAQGKRE 3263

Query: 3486 NACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGK 3545
                  +  +   C  P  ++         +   C     W+GS  H             
Sbjct: 3264 GKSFIYQSEVSFSCNFPFILVGS-------STRICQADGTWSGSSPH------------- 3303

Query: 3546 CVRPNRCHCLSSWTGHNCSRKRRTGF 3571
            C+ P +  C +     + S+    GF
Sbjct: 3304 CIEPTQTSCENPGVPRHGSQNNTFGF 3329



 Score =  330 bits (846), Expect = 2e-89
 Identities = 210/695 (30%), Positives = 297/695 (42%), Gaps = 42/695 (6%)

Query: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAGS 1710
            GS     CD GF LVG+ V+ CL+ G W++    C    CG+P  + NG    +++    
Sbjct: 2738 GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRD 2797

Query: 1711 TVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHAS--CLNVDGSY 1768
            TV YQCN G+ L+G S   C  + +W+G  PSC+ V     GS      S    N +   
Sbjct: 2798 TVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVV 2857

Query: 1769 ICSCVPPYTGDGKNCAE---------------PIKCKAPGNPENGHSSGEI----YTVGA 1809
              SC   Y   G   A+                + C  PG P N     +I    +T G 
Sbjct: 2858 TFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGT 2917

Query: 1810 EVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKV 1869
             V + C  GY L G + + C  +G+W+  +P C  + CG P +P N  +    +TFGS V
Sbjct: 2918 VVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTV 2977

Query: 1870 TYRCNKGYTLAGDKESSCLANSSWSHSPPVCE---PVKCSSPENINNGKYILSGLTYLST 1926
             Y C    +L G    +C  N  WS S P C       C  P    +G    S     ST
Sbjct: 2978 HYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKST 3037

Query: 1927 ASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDA-VITGNNFTFRNTV 1985
              Y+CDTGY L G     C A+G W    P C  V CG P    +  V   +  TF ++V
Sbjct: 3038 VRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSV 3097

Query: 1986 TYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFY 2045
             Y+C EGY L+G    +C A+G WS +   C  +SC +P I  +        + G    Y
Sbjct: 3098 IYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSY 3157

Query: 2046 YCSDGYSLADNSQLL--CNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFA 2103
             C  GY++  N   +  C   G W       MP C A  C  PP +S   LE  +   F 
Sbjct: 3158 MCQPGYTMELNGSRIRTCTINGTW----SGVMPTCRAVTCPTPPQISNGRLEGTN---FD 3210

Query: 2104 AGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYS 2163
             G  +S+ C  G+ L+  A + C+  G W  S    QC+P  CG+P     G   G ++ 
Sbjct: 3211 WGFSISYICSPGYELSFPAVLTCVGNGTW--SGEVPQCLPKFCGDPGIPAQGKREGKSFI 3268

Query: 2164 FGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTC---HPVSCGEPPKVENGFLEHTTG 2220
            + + V++SCN  F + G     C+A G WS   P C      SC  P    +G   +T G
Sbjct: 3269 YQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG 3328

Query: 2221 RIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENF 2280
                S V++ C  G+   GS    C  +  W    P  C+P  C +P    +  + G + 
Sbjct: 3329 FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP-ECIPHSCKQPETPAHANVVGMDL 3387

Query: 2281 -EVGSKVQFFCNEGYELVGDSSW-TCQKSGKWNKK 2313
               G  + + C  G+ L G +    C+    W  K
Sbjct: 3388 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGK 3422



 Score =  301 bits (772), Expect = 6e-81
 Identities = 193/638 (30%), Positives = 279/638 (43%), Gaps = 67/638 (10%)

Query: 1636 GSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPP 1695
            GS  + RT+         V   C+ G+ + G     C    QW+ P P C+ ++C  P  
Sbjct: 2839 GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGI 2898

Query: 1696 LENGFHSA----DDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAV 1751
              N    +     +F  G+ V Y CN GY+L G S + C  NG W+   P C+ +D    
Sbjct: 2899 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMID---- 2954

Query: 1752 GSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEV 1811
                                                 C  PG P N   SGE YT G+ V
Sbjct: 2955 -------------------------------------CGHPGVPPNAVLSGEKYTFGSTV 2977

Query: 1812 TFSCQEGYQLMGVTKITCLESGEWNHLIPYCK---AVSCGKPAIPENGCIEELAFTFGSK 1868
             +SC     L+G +  TC  +G W+   P+C      +CG P  P +G  +E  F   S 
Sbjct: 2978 HYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKST 3037

Query: 1869 VTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGK-YILSGLTYLSTA 1927
            V Y C+ GY L G +E +CLAN SW+   P C+ V+C +P    NGK + + G T+ S+ 
Sbjct: 3038 VRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSV 3097

Query: 1928 SYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTY 1987
             YSC  GY L GPS+ +CTA+G W    P C ++ CG+P    + +  G+++     V+Y
Sbjct: 3098 IYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSY 3157

Query: 1988 TCKEGYT--LAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFY 2045
             C+ GYT  L G     C  +G WS     C AV+C  PP + +   E  +  +G    Y
Sbjct: 3158 MCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISY 3217

Query: 2046 YCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAG 2105
             CS GY L+  + L C   G W      ++P+C+  FC  P   +    E  S   F   
Sbjct: 3218 ICSPGYELSFPAVLTCVGNGTW----SGEVPQCLPKFCGDPGIPAQGKREGKS---FIYQ 3270

Query: 2106 SVVSFKCMEGFVLNTSAKIECMRGGQWN-PSPMSIQCIPVRCGEPPSIMNGYASGS-NYS 2163
            S VSF C   F+L  S+   C   G W+  SP  I+     C  P    +G  + +  + 
Sbjct: 3271 SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQ 3330

Query: 2164 FGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIF 2223
             G++V + C KG  ++G    TC     WS   P C P SC +P   E     +  G   
Sbjct: 3331 VGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQP---ETPAHANVVGMDL 3387

Query: 2224 ESE---VRYQCNPGYKSVGSPVF-VCQANRHWHSESPL 2257
             S    + Y C PG+   G     VC+++  W  + P+
Sbjct: 3388 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPI 3425



 Score =  108 bits (269), Expect = 1e-22
 Identities = 312/1535 (20%), Positives = 502/1535 (32%), Gaps = 353/1535 (22%)

Query: 2102 FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWN-PSPMSIQCIPVRCGE---------PPS 2151
            F+ GS VSF C  G+ L+    + C +   W+ P P    C  +  G+          P 
Sbjct: 986  FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPT---CDALCGGDVRGPSGTILSPG 1042

Query: 2152 IMNGYASGSNYSFGAMVAYSCNKGF----YIKGEKKSTCEATGQWSSPIPTCHPVSCGEP 2207
                Y +  N ++   V +     F    +   +       T   S   P         P
Sbjct: 1043 YPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLP 1102

Query: 2208 PKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKP 2267
            P +  G   +     F +++R+  +      G  +   + N               C  P
Sbjct: 1103 PTINAGLYGN-----FRAQLRFISDFSISYEGFNITFSEYNLE------------PCEDP 1145

Query: 2268 PPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGK--WNKKSNPKCMPAKC-- 2323
               Q G   G NF +G  + F C+ GY L G S   C   G+  W+    P+C+ A+C  
Sbjct: 1146 GIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPL-PRCV-AECGA 1203

Query: 2324 -----------PEPPLL--ENQLVLKELTTEVGV-VTFSCKEGHVLQGPSV--------- 2360
                       P  PL    N   +  +  + G  +  S +  H+ QG  +         
Sbjct: 1204 SATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKT 1263

Query: 2361 ----------------LKCLPSQQW----------NDSFPVC----KIVLCTPPPLISFG 2390
                            L    +Q W          ++ F +     ++  C  P +  FG
Sbjct: 1264 THLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFG 1323

Query: 2391 VPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDG--TWSSPLPECVPVECPQPEEIPN 2448
              I       GST+ Y C  G+ L G+S   C       W  PLP C+     + +   +
Sbjct: 1324 YKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESS 1383

Query: 2449 GIIDVQGLAYLSTALYTCKPGFEL-VGNTTTLC-----GENGH-----WLGGKPTCKAIE 2497
            G I   G  +       C    E+  GN  +L       E  H     W G       ++
Sbjct: 1384 GRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLK 1443

Query: 2498 CLKPKEILNGKFSYTDLHYGQTVT--YSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIH 2555
             +    I  G  S  ++   Q  T  Y    GF ++  S++                A  
Sbjct: 1444 EISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSV----------------ATA 1487

Query: 2556 CDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG----WSSSIPTCMPI 2611
            C  P    NG   G     G  +++ C PG+++ G    TC +      W  S P C+  
Sbjct: 1488 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA- 1546

Query: 2612 DCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATH 2671
             CG            L    G+    +         PHP  H       W  T  +    
Sbjct: 1547 PCG----------GNLTGSSGFILSPN--------FPHPYPHSRDC--DWTITVNADYVI 1586

Query: 2672 SSNFLYGTMVSYTCNPGYELL--------GNPV---------------------LICQED 2702
            S  F     +S++  P Y+ L         +P+                     L  + D
Sbjct: 1587 SLAF-----ISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSD 1641

Query: 2703 GTWNGSA-----PSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLC 2757
            G+ + +       + +   C  P    NG     +  +GS V Y C  G++L G     C
Sbjct: 1642 GSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTC 1701

Query: 2758 LENRK----WSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYEC------DPGYVL 2807
            +        W+ A P C A  C   +    G++   NY    ++ + C         +V+
Sbjct: 1702 IMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVV 1760

Query: 2808 NGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTF----QKEIEYTCNEGF 2863
             G  +         D  E    P   SS   S +G   G+        Q  I +T     
Sbjct: 1761 FG--QFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPI 1818

Query: 2864 LLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYIL 2923
              +G              A P     +C++ P+   G   G ++     V F C+ GYIL
Sbjct: 1819 TAKGFHFVY--------QAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYIL 1870

Query: 2924 HGAPKLTCQSDGN----WDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGY 2979
            HG+  + C++  N    W+  +P C  V CG           G      G I     PGY
Sbjct: 1871 HGSIAIRCETVPNSLAQWNDSLPTC-IVPCG-----------GILTKRKGTI---LSPGY 1915

Query: 2980 KLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTD----FDCG--KAARIQCF 3033
                +++  C+    W  + P          V+ + T +  D    +D G   A R+  +
Sbjct: 1916 PEPYDNNLNCV----WKITVPE--GAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSY 1969

Query: 3034 KGFKLLGLSEITC-------EADGQWSSGFPHCEHTSCG----SLPMIPNAFISETSSWK 3082
             G  +  L   T        ++D   S+   H E+T+ G      P  P++ I     + 
Sbjct: 1970 SGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYM 2029

Query: 3083 -ENVITYSCRSGYVIQGSSDLICTEKGV--WSQPYPVCEPLSCGSPPSVANAVATGEAHT 3139
              +V+++ C  GY +QG S + C    V  W+ P P+C    CG   S  + V       
Sbjct: 2030 VGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC-LAQCGGAMSDFSGVILSPGFP 2088

Query: 3140 YESEVKLRC---------------------------LEGYTMDTDTDTFTCQKDGRWFPE 3172
                  L C                           LE  +  ++T T   +  G   P 
Sbjct: 2089 GNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPS 2148

Query: 3173 RISCSP---------------------------KKCPLPENITHILVHGDDFSVNRQVSV 3205
             +  +                            + CP P    +  V G+DF+V + +S 
Sbjct: 2149 SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISF 2208

Query: 3206 SCAEGYTFEGVNISVC--QLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTI 3263
             C  GYT  G +   C   +   W  P     C  + CG   +  +G +    Y  E   
Sbjct: 2209 ECFPGYTLIGNSALTCLHGVSRNWNHPL--PRCEAL-CGGNITAMNGTIYSPGYPDEYPN 2265

Query: 3264 IYQC------EPGYELEGN-----RERVCQENRQWSGGVAICKETRCETPLEFLNGKADI 3312
               C       PG  +  N      E +      W G        +    +   +G   +
Sbjct: 2266 FQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDG------PDQNSPQIGQFSGNTAL 2319

Query: 3313 ENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTW-----SHPVPLCKPNPCPVPFVIPENA 3367
            E+       VYS +    ++  S+   T +G +     ++ + +C+P P PVP       
Sbjct: 2320 ES-------VYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLRVCQPPP-PVP---NAEI 2366

Query: 3368 LLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDE 3402
            L  + EF +   +  +C  GF L G+ I+TC   E
Sbjct: 2367 LTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGE 2401



 Score =  107 bits (268), Expect = 2e-22
 Identities = 296/1393 (21%), Positives = 465/1393 (33%), Gaps = 236/1393 (16%)

Query: 1620 KIDSKSIFCSDCPRLGGSVP-HLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQW 1678
            KI  +S+  +    L   +P H R    D   GS V+  CD G++L       C     W
Sbjct: 957  KIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWW 1016

Query: 1679 TQPLPHCERISCG--VPPP----LENGFHSADDFYAGS-------TVTY----QCNNGYY 1721
            + PLP C+ + CG  V  P    L  G+    +FY  S        VT+    Q N   +
Sbjct: 1017 SHPLPTCDAL-CGGDVRGPSGTILSPGY---PEFYPNSLNCTWTVDVTHGKGVQFNFHTF 1072

Query: 1722 LLGDSR--MFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASC-----LNVDGSYICSCVP 1774
             L D    +  T+NGS+               GSD     +            +I     
Sbjct: 1073 HLEDHHDYLLITENGSFTQPLAR-------LTGSDLPPTINAGLYGNFRAQLRFISDFSI 1125

Query: 1775 PYTGDGKNCAE--PIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLES 1832
             Y G     +E     C+ PG P+ G   G  + +G  +TFSC  GY+L G ++I CL  
Sbjct: 1126 SYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGG 1185

Query: 1833 GE--WNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLAN 1890
            G   W+  +P C A  CG  A    G +    +    +  + C     +   K  +  A 
Sbjct: 1186 GRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISAR 1244

Query: 1891 SSWSHSPPVCEPVKCSSPENINNGKYI---LSGLTYLSTASYSCDTGYSLQGPSIIECTA 1947
            +       V +            G +    + GLT  ST++        L+  S  E T 
Sbjct: 1245 TFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQ-----LWLEFNSDTEGTD 1299

Query: 1948 SGIWDRAPPACHLVFCGEP--PAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLA 2005
             G +     +  L  C +P  P     +    +F   +T+ Y C  GYTL G   ++C+ 
Sbjct: 1300 EG-FQLVYTSFELSHCEDPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMT 1357

Query: 2006 DGK--WSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNA 2063
              +  W      C+A              E   R  G+ +    S GY    ++ L C  
Sbjct: 1358 GERRAWDYPLPSCIA--------------ECGGRFKGESSGRILSPGYPFPYDNNLRCMW 1403

Query: 2064 QGKWVPPEGQDMPRCIAHFCEKPPSVSYSIL-------ESVSKAKFAAGSVVSFKCMEGF 2116
              +  P     +      F       S+ IL       E+    K  +GS++     EG 
Sbjct: 1404 MIEVDPGNIVSL-----QFLAFDTEASHDILRVWDGPPENDMLLKEISGSLIP----EGI 1454

Query: 2117 --VLNTSAKIECMRGGQWNPSPMSIQ---CIPVRCGEPPSIMNGYASGSNYSFGAMVAYS 2171
               LN    I+       + S  +IQ    +   C +P   MNG  +G     G  V + 
Sbjct: 1455 HSTLNI-VTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQ 1513

Query: 2172 CNKGFYIKGEKKSTC---EATGQWSSPIPTCHPVSCGEPPKVENGFL-----EHTTGRIF 2223
            C+ G+ ++GE++ TC   E    W    P C    CG      +GF+      H      
Sbjct: 1514 CDPGYELQGEERITCIQVENRYFWQPSPPVC-IAPCGGNLTGSSGFILSPNFPHPYPHSR 1572

Query: 2224 ESEVRYQCNPGYK-SVGSPVFVCQANRHW-------HSESPLMCVPLDCGKPPPIQNGFM 2275
            + +     N  Y  S+    F  + N  +        S SPL+    D   P        
Sbjct: 1573 DCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLP-------- 1624

Query: 2276 KGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVL 2335
              E  E  S            V  + +  +   K         +   C +P  + N   L
Sbjct: 1625 --ERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK---------LRESCFDPGNIMNGTRL 1673

Query: 2336 KELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQ----WNDSFPVC-------------KI 2378
                     VT+ C  G+VLQG S L C+        WN + P C              +
Sbjct: 1674 GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTV 1733

Query: 2379 VLCTPPPLISFG------VPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDG-TWSSP 2431
            +    P   S G      + +P   + FG  V       FF       +   DG T  S 
Sbjct: 1734 LSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFV-------FFQTSLHDVVEVYDGPTQQSS 1786

Query: 2432 LPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKP 2491
            L   +       E +P    +   + + S    T K GF  V                 P
Sbjct: 1787 LLSSLS-GSHSGESLPLSSGNQITIRFTSVGPITAK-GFHFVYQAV-------------P 1831

Query: 2492 TCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLET-----GDWDV 2546
               + +C    E   G+    +   G +V + CN G+ L G  A+ C ET       W+ 
Sbjct: 1832 RTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRC-ETVPNSLAQWND 1890

Query: 2547 DAPSCNAIHCD------SPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG 2600
              P+C  + C           +  G+ E  D +   +   +   G  +    +    E  
Sbjct: 1891 SLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN 1949

Query: 2601 WSS---------SIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPP 2651
            W S         + P          PH+       L     Y   + D+           
Sbjct: 1950 WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNL-----YLNFQSDIS-----VSAAG 1999

Query: 2652 YHLGAVAKTWENTKESPATHSS------NFLYGTMVSYTCNPGYELLGNPVLICQEDGT- 2704
            +HL   A   ++  E P T SS       ++ G +VS+ C+ GY L G+  + C      
Sbjct: 2000 FHLEYTAIGLDSCPE-PQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVR 2058

Query: 2705 -WNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCK-PGHILAGSDLRLCLENRK 2762
             WN   P C++ +C    +  +G +              C    ++  G  + L   N  
Sbjct: 2059 RWNYPIPICLA-QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFS 2117

Query: 2763 WSGASPRCEAISCKKPNPVMNGSIKGS-------NYTYLSTLYYECDPGYVLNGTERRTC 2815
                    E  S       + G + G        + T+ ++LY+  D             
Sbjct: 2118 TETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSD-----------YS 2166

Query: 2816 QDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCL- 2874
            Q+ + +           C  P    NG V G+++T  + I + C  G+ L G  +  CL 
Sbjct: 2167 QNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLH 2226

Query: 2875 -ANGSWSGATPDC 2886
              + +W+   P C
Sbjct: 2227 GVSRNWNHPLPRC 2239



 Score =  105 bits (261), Expect = 1e-21
 Identities = 253/1208 (20%), Positives = 414/1208 (34%), Gaps = 286/1208 (23%)

Query: 2264 CGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGK----WNKKSNPKCM 2319
            C  P   +NG   G +F +GS VQF C+E Y L G  S TCQ+  +    W+    P C 
Sbjct: 446  CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWS-DHRPVCK 504

Query: 2320 PAKC-------------PEPPLLEN------------------QLVLKELTTEVGVVTFS 2348
               C             P  P   +                  Q+  +E   E+G  T +
Sbjct: 505  VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564

Query: 2349 CKEG----------HVLQG---PSVLKCLPSQQW--------------NDSFPVCKIVLC 2381
              +G           VL G   P ++  + SQ W                ++   +   C
Sbjct: 565  IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624

Query: 2382 TPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECP 2441
              P    +G+            +++ C  GF L G  + +CQ +  WS+ +P C+   C 
Sbjct: 625  GDPGTPLYGIR-EGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICI-FPCL 682

Query: 2442 QPEEIPNGII----DVQGLAYLSTALYT--CKPG---------FELVGNTTTLCGENGHW 2486
                 P G +      +G       ++T    PG         F+L      L  ++G  
Sbjct: 683  SNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD- 741

Query: 2487 LGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDV 2546
                          P+  + G F+  ++    T   S +   RLE  +  +    G +++
Sbjct: 742  -------------SPESPILGTFTGAEVPSHLT---SNSHILRLEFQADHSMSGRG-FNI 784

Query: 2547 DAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGF-QVAGHAMQTC----EESGW 2601
               +     C  P    N    G ++  G+ I   C  GF +  G    TC     +  W
Sbjct: 785  TYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMW 844

Query: 2602 SSSIPTC-------------------------MPIDCGLPPHIDFGDCTKLKDDQGYFEQ 2636
            S  IP C                           ++C      + G   K+  ++   E 
Sbjct: 845  SGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTEL 904

Query: 2637 EDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHS-SNFLY--GTMVSYTCNPGYELLG 2693
              D++EV       P  L  +  ++  T+      S SNF+Y   T  +   N G+++  
Sbjct: 905  NYDVLEV----HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHY 960

Query: 2694 NPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSD 2753
              V +         +  SC+      P  P +G     + S+GS V +SC  G+ L+  +
Sbjct: 961  ESVTV---------NTYSCLD-----PGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEE 1006

Query: 2754 LRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPG-----YVLN 2808
              LC +N  WS   P C+A+          G ++G + T LS  Y E  P      + ++
Sbjct: 1007 PLLCEKNHWWSHPLPTCDAL--------CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVD 1058

Query: 2809 GTERRTCQDD----------------KNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQ 2852
             T  +  Q +                +N    +P+        PP + N  + G+   F+
Sbjct: 1059 VTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPP-TINAGLYGN---FR 1114

Query: 2853 KEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKE 2912
             ++ +  +     EG        N              C  P     G   G ++G    
Sbjct: 1115 AQLRFISDFSISYEGFNITFSEYNLE-----------PCEDPGIPQYGSRIGFNFGIGDT 1163

Query: 2913 VTFHCHEGYILHGAPKLTCQSDGN--WDAEIPLCKPVNCGPPED------LAHGFPNGFS 2964
            +TF C  GY L G  ++ C   G   W A +P C    CG          L+  +P  + 
Sbjct: 1164 LTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC-VAECGASATNNEGILLSPNYPLNYE 1222

Query: 2965 FIHG--GHIQYQCFPG---------------YKLHGNSSRRCLSNGSWSGSSPSCLPCRC 3007
              H     IQ Q   G                K++    +     G+++G+S   L    
Sbjct: 1223 NNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSS 1282

Query: 3008 STPV--IEYGT-VNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSC 3064
            ++    +E+ +   GTD            +GF+L+             S    HCE    
Sbjct: 1283 TSNQLWLEFNSDTEGTD------------EGFQLV-----------YTSFELSHCED--- 1316

Query: 3065 GSLPMIP--NAFISETSSWKENVITYSCRSGYVIQGSSDLICT--EKGVWSQPYPVCEPL 3120
               P IP     IS+   +  + I Y C  GY + GSS L C   E+  W  P P C   
Sbjct: 1317 ---PGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE 1373

Query: 3121 SCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPE------RI 3174
              G     ++       + +  +  LRC+  + ++ D       +   +  E      R+
Sbjct: 1374 CGGRFKGESSGRILSPGYPFPYDNNLRCM--WMIEVDPGNIVSLQFLAFDTEASHDILRV 1431

Query: 3175 SCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTW---EPPF 3231
               P     PEN   +          +++S S         +NI   Q D  +   +  F
Sbjct: 1432 WDGP-----PENDMLL----------KEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGF 1476

Query: 3232 SDESCSPV--SCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVC--QENRQ- 3286
            + +  S V  +C  P  P +G   G       T+++QC+PGYEL+G     C   ENR  
Sbjct: 1477 AIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYF 1536

Query: 3287 WSGGVAIC 3294
            W     +C
Sbjct: 1537 WQPSPPVC 1544



 Score = 89.7 bits (221), Expect = 5e-17
 Identities = 73/289 (25%), Positives = 117/289 (40%), Gaps = 41/289 (14%)

Query: 307  CEKGYYGKG-LQYECTACPSGTYKPEGSPGGISSC--IPCPDENHT----SPPGSTS--- 356
            C+ GY+G G    EC    + +++ E     I SC  +P P   +     +  GST+   
Sbjct: 2685 CDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFT 2744

Query: 357  -----------PEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVR 405
                         +C+    +  S   C   HC   +   NG  I    N  +      +
Sbjct: 2745 CDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGE--NYGYRDTVVYQ 2802

Query: 406  CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA 465
            C+PGF L+GSS+ +C  +  WSG    C   +C H   P +G    S     +      +
Sbjct: 2803 CNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGR--TSGNGFNFNDVVTFS 2860

Query: 466  CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAK----- 520
            C+ GY ++G  K  CQ N QW  P P C   +CS   +P +         K+ +K     
Sbjct: 2861 CNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPAN--------SKRESKIEHGN 2912

Query: 521  --FGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQI 567
              +GT+ +  C  G+ L G   +L C  +G+W+  +   +  D   P +
Sbjct: 2913 FTYGTVVFYDCNPGYFLFG-SSVLICQPNGQWDKPLPECIMIDCGHPGV 2960



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 139/641 (21%), Positives = 224/641 (34%), Gaps = 119/641 (18%)

Query: 1698 NGFHSADDFYAGSTVTYQCNNGYYLL-GDSRMFCT---DNGSWNGVSPSCLDVDECAVGS 1753
            N     D+F  GS+++  C  G+    G   + C        W+G+ P C        G+
Sbjct: 802  NARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC--------GA 853

Query: 1754 DCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNP----------ENGHSSGE 1803
             C  H S  +  G  +    P Y  D  NC   I+ + PG+           E  +   E
Sbjct: 854  PCGGHFSAPS--GVILSPGWPGYYKDSLNCEWVIEAE-PGHSIKITFERFQTELNYDVLE 910

Query: 1804 IY---------------TVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYC-KAVSC 1847
            ++               T   +  FS      L+  T  +   +G   H         SC
Sbjct: 911  VHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 970

Query: 1848 GKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSS 1907
              P IP +G      F+ GS V++ C+ GY L+ ++   C  N  WSH  P C+ + C  
Sbjct: 971  LDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL-CGG 1029

Query: 1908 PENINNGKYILSG----------------LTYLSTASYSCDTGYSLQGPSIIECTASGIW 1951
                 +G  +  G                +T+     ++  T +       +  T +G +
Sbjct: 1030 DVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSF 1089

Query: 1952 DRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSR 2011
             +  P   L     PP I +A + GN   FR  + +      +  G +            
Sbjct: 1090 TQ--PLARLTGSDLPPTI-NAGLYGN---FRAQLRFISDFSISYEGFNI----------- 1132

Query: 2012 SDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGK--WVP 2069
            +  +     C++P I  + S    +   GD   + CS GY L   S+++C   G+  W  
Sbjct: 1133 TFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSA 1192

Query: 2070 PEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRG 2129
            P    +PRC+A  C    + +  IL S                   + LN     EC+  
Sbjct: 1193 P----LPRCVAE-CGASATNNEGILLS-----------------PNYPLNYENNHECIYS 1230

Query: 2130 GQWNPSP---MSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKG------ 2180
             Q        +S +   +  G+   I +G    + +  GA    S  +G  +        
Sbjct: 1231 IQVQAGKGINISARTFHLAQGDVLKIYDG-KDKTTHLLGAFTGASM-RGLTLSSTSNQLW 1288

Query: 2181 -EKKSTCEATGQWSSPIPTCHPVS-CGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSV 2238
             E  S  E T +    + T   +S C +P   + G+     G    S + Y CNPGY   
Sbjct: 1289 LEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLH 1348

Query: 2239 GSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGEN 2279
            GS +  C        + PL     +CG       G  KGE+
Sbjct: 1349 GSSLLKCMTGERRAWDYPLPSCIAECG-------GRFKGES 1382



 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 252/1237 (20%), Positives = 409/1237 (33%), Gaps = 316/1237 (25%)

Query: 2203 SCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPL----- 2257
            SCG+P     G  E   G      +R++C  G++ +G    VCQ N  W +  P+     
Sbjct: 623  SCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 681

Query: 2258 ---MCVPLDCGKPPPIQNGFMKGEN------FEVGSKVQFFCNEGYELVGDSSWTCQKSG 2308
                  P+     P    G+    N       + GS++    N+ ++L     +   K G
Sbjct: 682  LSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFND-FDLESQFDFLAVKDG 740

Query: 2309 KWNKKSNPKCMPAKCPEPPLL---ENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLP 2365
                           PE P+L       V   LT+   ++    +  H + G        
Sbjct: 741  -------------DSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSG-------- 779

Query: 2366 SQQWNDSFPVCKIVLCTPPPLISFGVPIPS----SALHFGSTVKYSCVGGFF-LRGNSTT 2420
             + +N ++       C  P     G+PI +         GS++   C  GF   +G  T 
Sbjct: 780  -RGFNITYNTFGHNECPDP-----GIPINARRFGDNFQLGSSISVICEEGFIKTQGTETI 833

Query: 2421 LC-QPDG--TWSSPLPECVPVECPQPEEIPNGIIDVQGL-AYLSTAL-----YTCKPG-- 2469
             C   DG   WS  +P+C    C      P+G+I   G   Y   +L        +PG  
Sbjct: 834  TCILMDGKVMWSGLIPKC-GAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHS 892

Query: 2470 -------FELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTY 2522
                   F+   N   L   +G  L   P   +    +  + L    ++  L +  T   
Sbjct: 893  IKITFERFQTELNYDVLEVHDGPNL-LSPLLGSYNGTQVPQFLFSSSNFIYLLF-TTDNS 950

Query: 2523 SCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSC 2582
              N GF++                ++ + N   C  P    +G   G D+S G+ + +SC
Sbjct: 951  RSNNGFKIH--------------YESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSC 996

Query: 2583 FPGFQVAGHAMQTCEES-GWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMM 2641
              G++++      CE++  WS  +PTC  + CG       GD   ++   G         
Sbjct: 997  DSGYRLSHEEPLLCEKNHWWSHPLPTCDAL-CG-------GD---VRGPSG--------- 1036

Query: 2642 EVPYVTP-HPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQ 2700
                ++P +P ++  ++  TW          + +  +G  V +  +  +    +  L+  
Sbjct: 1037 --TILSPGYPEFYPNSLNCTW----------TVDVTHGKGVQFNFHTFHLEDHHDYLLIT 1084

Query: 2701 EDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN 2760
            E+G++  + P       DLP     G              Y      +   SD  +  E 
Sbjct: 1085 ENGSF--TQPLARLTGSDLPPTINAGL-------------YGNFRAQLRFISDFSISYEG 1129

Query: 2761 RKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDD-- 2818
               + +    E   C+ P     GS  G N+    TL + C  GY L GT    C     
Sbjct: 1130 FNITFSEYNLE--PCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGR 1187

Query: 2819 KNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTC------------------- 2859
            + W    P C+  +C +   +  G +    Y    E  + C                   
Sbjct: 1188 RVWSAPLPRCV-AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTF 1246

Query: 2860 --NEGFLLE--GARSRVCLANGSWSGATPDCVPVRCATPPQL---ANGVTEGLDYGFMKE 2912
               +G +L+    + +     G+++GA+   + +  +T  QL    N  TEG D GF   
Sbjct: 1247 HLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTL-SSTSNQLWLEFNSDTEGTDEGFQLV 1305

Query: 2913 VT----FHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHG 2968
             T     HC +  I     K++ Q                         G   G + I+G
Sbjct: 1306 YTSFELSHCEDPGIPQFGYKISDQ-------------------------GHFAGSTIIYG 1340

Query: 2969 GHIQYQCFPGYKLHGNSSRRCLS--NGSWSGSSPSCL-PC----------RCSTPVIEYG 3015
                  C PGY LHG+S  +C++    +W    PSC+  C          R  +P   + 
Sbjct: 1341 ------CNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFP 1394

Query: 3016 TVNG------TDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPM 3069
              N        + D G    +Q F  F      +I    DG   +            L  
Sbjct: 1395 YDNNLRCMWMIEVDPGNIVSLQ-FLAFDTEASHDILRVWDGPPENDM---------LLKE 1444

Query: 3070 IPNAFISETSSWKENVIT-------YSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSC 3122
            I  + I E      N++T       Y  +SG+ IQ SS +                  +C
Sbjct: 1445 ISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSV----------------ATAC 1488

Query: 3123 GSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCP 3182
              P    N    G+       V  +C  GY +  +      Q + R+F +    SP  C 
Sbjct: 1489 RDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQP---SPPVCI 1545

Query: 3183 LP--------------ENITHILVHGDD----FSVNRQVSVSCA-----------EGYTF 3213
             P               N  H   H  D     +VN    +S A             Y +
Sbjct: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1605

Query: 3214 EGVNISVCQLDGTWEP---PFSDESCSPV--------------------------SCGKP 3244
            +G + S   L G+++    P   ES S                            SC  P
Sbjct: 1606 DGPD-SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP 1664

Query: 3245 ESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVC 3281
             +  +G  +G  Y   ST+ Y C+ GY L+G     C
Sbjct: 1665 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTC 1701



 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 107/435 (24%), Positives = 159/435 (36%), Gaps = 83/435 (19%)

Query: 1632 PRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCL----NQGQWTQPLPHC-- 1685
            PR G      R    +   GS V   C+PG+ L G+    C     +  QW   LP C  
Sbjct: 1844 PRFG------RRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIV 1897

Query: 1686 -----------ERISCGVPPPLENGFHSADDFYA--GSTVTYQCNN----------GYYL 1722
                         +S G P P +N  +         G+ +  Q  +           +Y 
Sbjct: 1898 PCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYD 1957

Query: 1723 LGDSRMFCTDNGSWNGVS-PSCLDVDECAV----GSDCSEHASCLNVDGSYICSCVPPYT 1777
             GD+       GS++G + P  L+     +     SD S  A+  +++          YT
Sbjct: 1958 GGDNN--APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLE----------YT 2005

Query: 1778 GDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLES--GEW 1835
              G +      C  P  P +G   G+ Y VG  V+F C +GY L G + ITC+      W
Sbjct: 2006 AIGLD-----SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 2060

Query: 1836 NHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTL-AGDKESSCLANSSWS 1894
            N+ IP C A  CG      +G I    F      +  C     L  G        N S  
Sbjct: 2061 NYPIPICLA-QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE 2119

Query: 1895 HSPPVCEPVKCSSPENIN-----NGKYILSGL---TYLSTASYSCDTGYSLQGPSIIECT 1946
                  E V+  S E        +G  I S L   T+ ++  +  D   + QG  I+   
Sbjct: 2120 TIHDYLE-VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVY-- 2176

Query: 1947 ASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECL-- 2004
                      A  L  C +P   ++  + GN+FT   T+++ C  GYTL G   + CL  
Sbjct: 2177 ---------QAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHG 2227

Query: 2005 ADGKWSRSDQQCLAV 2019
                W+    +C A+
Sbjct: 2228 VSRNWNHPLPRCEAL 2242



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 49/157 (31%), Positives = 65/157 (41%), Gaps = 10/157 (6%)

Query: 398  FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCR---VRTCPHLRQPKHGHISCSTR 454
            F +     C     L+G S   C  NG WSGS+ +C      TC     P HG  S    
Sbjct: 2973 FGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG--SRQES 3030

Query: 455  EMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNC 514
                K+T   ACD GY L GS++ TC  N  W G +P C    C           +    
Sbjct: 3031 NFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGN----PGTTANGKVF 3086

Query: 515  GKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
                  F +    SC +G+ILSG   + +CT +G W+
Sbjct: 3087 RIDGTTFSSSVIYSCMEGYILSG-PSVRQCTANGTWS 3122



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 66/251 (26%), Positives = 95/251 (37%), Gaps = 30/251 (11%)

Query: 315  GLQYECTACPSGT---------YKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREG 365
            G Q EC A   G          ++ +G+    S    C +    S P   S   C     
Sbjct: 3064 GRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGP---SVRQCTANGT 3120

Query: 366  YRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGF--DLVGSSIILCLPN 423
            +  +   C ++ C     P NG    +      N +    C PG+  +L GS I  C  N
Sbjct: 3121 WSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVS--YMCQPGYTMELNGSRIRTCTIN 3178

Query: 424  GLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGN 483
            G WSG    CR  TCP   Q  +G +  +  +  +  + +  C  GY L     LTC GN
Sbjct: 3179 GTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYI--CSPGYELSFPAVLTCVGN 3236

Query: 484  SQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAK---FGTICYVSCRQGFILSGVKE 540
              W G  P+C+ + C    +P          GK+  K   + +    SC   FIL G   
Sbjct: 3237 GTWSGEVPQCLPKFCGDPGIPAQ--------GKREGKSFIYQSEVSFSCNFPFILVGSST 3288

Query: 541  MLRCTTSGKWN 551
             + C   G W+
Sbjct: 3289 RI-CQADGTWS 3298



 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 101/450 (22%), Positives = 169/450 (37%), Gaps = 67/450 (14%)

Query: 1785 EPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKA 1844
            E   C  PG P  G   G+ ++    + F CQ G++L+G   I C E+ +W+  IP C  
Sbjct: 620  EKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF 679

Query: 1845 VSCGK----------PAIPEN-----GCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLA 1889
                           P  PE       CI  +    GS++    N  + L    +   + 
Sbjct: 680  PCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFND-FDLESQFDFLAVK 738

Query: 1890 NSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASG 1949
            +     SP +        P ++ +  +IL          +  D   S +G +I   T   
Sbjct: 739  DGDSPESPILGTFTGAEVPSHLTSNSHILR-------LEFQADHSMSGRGFNITYNTFGH 791

Query: 1950 IWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLA-GLDTIEC-LADG 2007
                         C +P    +A   G+NF   ++++  C+EG+    G +TI C L DG
Sbjct: 792  NE-----------CPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDG 840

Query: 2008 K--WSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQG 2065
            K  WS    +C A      P   H S  +   L      YY            L C    
Sbjct: 841  KVMWSGLIPKCGA------PCGGHFSAPSGVILSPGWPGYY---------KDSLNC---- 881

Query: 2066 KWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCME--GFVLNTSAK 2123
            +WV  E +        F      ++Y +LE        +  + S+   +   F+ ++S  
Sbjct: 882  EWVI-EAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNF 940

Query: 2124 IECM----RGGQWNPSPMSIQCIPVR---CGEPPSIMNGYASGSNYSFGAMVAYSCNKGF 2176
            I  +         N   +  + + V    C +P   ++G   G ++S G+ V++SC+ G+
Sbjct: 941  IYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGY 1000

Query: 2177 YIKGEKKSTCEATGQWSSPIPTCHPVSCGE 2206
             +  E+   CE    WS P+PTC  +  G+
Sbjct: 1001 RLSHEEPLLCEKNHWWSHPLPTCDALCGGD 1030



 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 68/245 (27%), Positives = 97/245 (39%), Gaps = 36/245 (14%)

Query: 335  GGISSCIPCPDENHTSPP-GSTSPE-----DCV---CREGYRASGQT------------- 372
            G + SC+P    +  SP  G TS       D V   C  GY   G T             
Sbjct: 2825 GQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHP 2884

Query: 373  ---CELVHCPALKPPENGYFIQNTCNNHFNAACGV--RCHPGFDLVGSSIILCLPNGLWS 427
               C++V+C     P N        + +F     V   C+PG+ L GSS+++C PNG W 
Sbjct: 2885 PPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWD 2944

Query: 428  GSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWD 487
                 C +  C H   P +  +S    +  + +T   +C     L G    TCQ N  W 
Sbjct: 2945 KPLPECIMIDCGHPGVPPNAVLS--GEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWS 3002

Query: 488  GPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYV--SCRQGFILSGVKEMLRCT 545
            G +P C      T   P     +P +  +Q + F T   V  +C  G+IL G +E   C 
Sbjct: 3003 GSQPHCSGDATGTCGDPG----TPGHGSRQESNFRTKSTVRYACDTGYILHGSEER-TCL 3057

Query: 546  TSGKW 550
             +G W
Sbjct: 3058 ANGSW 3062



 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 54/195 (27%), Positives = 77/195 (39%), Gaps = 12/195 (6%)

Query: 361  VCREGYRASGQ--TCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSII 418
            +C++ +  SGQ  +C  V C     P  G    N  N  FN      C+ G+ + G +  
Sbjct: 2816 ICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFN--FNDVVTFSCNIGYLMQGPTKA 2873

Query: 419  LCLPNGLWSGSESYCRVRTC--PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSD 476
             C  N  WS     C+V  C  P +                Y T     C+ GY L GS 
Sbjct: 2874 QCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSS 2933

Query: 477  KLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILS 536
             L CQ N QWD P P C+   C    +P + ++S      +   FG+  + SC     L 
Sbjct: 2934 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLS-----GEKYTFGSTVHYSCTGKRSLL 2988

Query: 537  GVKEMLRCTTSGKWN 551
            G +    C  +G W+
Sbjct: 2989 G-QSSRTCQLNGHWS 3002



 Score = 70.5 bits (171), Expect = 3e-11
 Identities = 184/848 (21%), Positives = 291/848 (34%), Gaps = 158/848 (18%)

Query: 2337 ELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCK-------IVLCTPPPLISF 2389
            E T E+ VVT   K+    +     K  P +  ++ F +           LC  P     
Sbjct: 396  ERTKELAVVTHRVKKAIDFKSRG-FKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPEN 454

Query: 2390 GVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQ----PDGTWSSPLPECVPVECPQPEE 2445
            G  I S     GSTV++SC   + L+G  +  CQ        WS   P C    C    +
Sbjct: 455  GKRIGSD-FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQ 513

Query: 2446 IPNGIIDVQGL----------AYLSTALYTCK------PGFEL-VGNTTTLCGENGHWLG 2488
             P+G                  ++ TA+ T K        F+L +G  T   G+ G  +G
Sbjct: 514  GPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGE-VG 572

Query: 2489 GKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDA 2548
               T          ++L G F   DL     V+ S      L+   ++  +    + V+ 
Sbjct: 573  DPRTV--------LQVLTGSF-VPDL----IVSMSSQMWLHLQTDESVGSV---GFKVNY 616

Query: 2549 PSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPT 2607
                   C  P     G  EG  +S   ++ + C  GF++ G     C+E+  WS++IP 
Sbjct: 617  KEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPI 676

Query: 2608 CM---------PIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVA 2658
            C+         P+   L P    G    L             + + +           +A
Sbjct: 677  CIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLA 736

Query: 2659 KTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCI----- 2713
                ++ ESP      F    + S+  +  + L     L  Q D + +G   +       
Sbjct: 737  VKDGDSPESPIL--GTFTGAEVPSHLTSNSHILR----LEFQADHSMSGRGFNITYNTFG 790

Query: 2714 SIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHI-LAGSDLRLCL---ENRKWSGASPR 2769
              EC  P  P N         +GS++   C+ G I   G++   C+       WSG  P+
Sbjct: 791  HNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPK 850

Query: 2770 CEAISCKKPNPVMNGSIKGSNYT--YLSTL----YYECDPGYVLNGTERRTCQDDKNWDE 2823
            C A  C       +G I    +   Y  +L      E +PG+ +  T  R  Q + N+D 
Sbjct: 851  CGA-PCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFER-FQTELNYDV 908

Query: 2824 DEPICIPVDCSSPPVSANGQVRGDEYTF-QKEIEYTCNEGFLLEGARSRVCLANG---SW 2879
             E    P +  SP + +    +  ++ F      Y     F  + +RS     NG    +
Sbjct: 909  LEVHDGP-NLLSPLLGSYNGTQVPQFLFSSSNFIYLL---FTTDNSRSN----NGFKIHY 960

Query: 2880 SGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDA 2939
               T +     C  P    +G   G D+     V+F C  GY L     L C+ +  W  
Sbjct: 961  ESVTVN--TYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSH 1018

Query: 2940 EIPLC-------------------------KPVNCGPPEDLAHGFPNGFSFIHGGHIQYQ 2974
             +P C                           +NC    D+ HG    F+F H  H++  
Sbjct: 1019 PLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNF-HTFHLEDH 1077

Query: 2975 ------------CFPGYKLHGNSSRRCLSNG-----------------SWSG-----SSP 3000
                          P  +L G+     ++ G                 S+ G     S  
Sbjct: 1078 HDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEY 1137

Query: 3001 SCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQ--WSSGFPH 3058
            +  PC     + +YG+  G +F  G      C  G++L G SEI C   G+  WS+  P 
Sbjct: 1138 NLEPCE-DPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPR 1196

Query: 3059 CEHTSCGS 3066
            C    CG+
Sbjct: 1197 CV-AECGA 1203



 Score = 70.1 bits (170), Expect = 4e-11
 Identities = 51/200 (25%), Positives = 82/200 (41%), Gaps = 15/200 (7%)

Query: 372  TCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSES 431
            TC  V CP      NG  ++ T N  +  +    C PG++L   +++ C+ NG WSG   
Sbjct: 3187 TCRAVTCPTPPQISNGR-LEGT-NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVP 3244

Query: 432  YCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEP 491
             C  + C     P  G      +  +Y++    +C+  + L GS    CQ +  W G  P
Sbjct: 3245 QCLPKFCGDPGIPAQG--KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSP 3302

Query: 492  RCVERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQGFILSGVKEMLRCTTSGK 549
             C+E   ++ + P    +  H        F  G++    C++G +L G      C     
Sbjct: 3303 HCIEPTQTSCENPG---VPRHGSQNNTFGFQVGSVVQFHCKKGHLLQG-STTRTCLPDLT 3358

Query: 550  WNVGVQAAV----CKDVEAP 565
            W+ G+Q       CK  E P
Sbjct: 3359 WS-GIQPECIPHSCKQPETP 3377



 Score = 70.1 bits (170), Expect = 4e-11
 Identities = 52/195 (26%), Positives = 81/195 (41%), Gaps = 20/195 (10%)

Query: 406  CHPGFDLVGSSIILCLPNGLWSGSESYCRVRT---CPHLRQPKHGHISCSTREMLYKTTC 462
            C+  F LVGSS  +C  +G WSGS  +C   T   C +   P+HG  + +T      +  
Sbjct: 3277 CNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVV 3335

Query: 463  LVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFG 522
               C +G+ L+GS   TC  +  W G +P C+   C   + P    +     G      G
Sbjct: 3336 QFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANV----VGMDLPSHG 3391

Query: 523  TICYVSCRQGFILSGVKEMLRCTTSGKWNVGV------QAAVCKD------VEAPQINCP 570
                 +C+ GF L+G  E   C +   W   V         + KD        +P+++ P
Sbjct: 3392 YTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTPSPKLSVP 3451

Query: 571  KDIEAKTLEQQDSAN 585
             D+ A+    + S N
Sbjct: 3452 DDVFAQNYIWKGSYN 3466



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 156/783 (19%), Positives = 276/783 (35%), Gaps = 108/783 (13%)

Query: 2680 MVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAV 2739
            ++ + C  G+EL+G   ++CQE+  W+ + P CI       TAP  G +   +   G   
Sbjct: 645  VLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPM-GTVLSPDYPEGYGN 703

Query: 2740 QYSCKPGHIL-AGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNY------- 2791
              +C    I   GS + L   +                 P   + G+  G+         
Sbjct: 704  NLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSN 763

Query: 2792 TYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTF 2851
            +++  L ++ D  + ++G       +    +E         C  P +  N +  GD +  
Sbjct: 764  SHILRLEFQAD--HSMSGRGFNITYNTFGHNE---------CPDPGIPINARRFGDNFQL 812

Query: 2852 QKEIEYTCNEGFL-LEGARSRVC-LANGS--WSGATPDCVPVRCATPPQLANGVTEGLDY 2907
               I   C EGF+  +G  +  C L +G   WSG  P C    C       +GV     +
Sbjct: 813  GSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC-GAPCGGHFSAPSGVILSPGW 871

Query: 2908 -GFMKEVTFHCHEGYILHGAP----KLTC---QSDGNWDAEIPLCKPVNCGPPEDLAHGF 2959
             G+ K+ + +C   +++   P    K+T    Q++ N+D       P    P     +G 
Sbjct: 872  PGYYKD-SLNCE--WVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGT 928

Query: 2960 PNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNG 3019
                      +  Y  F       N+  + +   S + ++ SCL      PV  +G   G
Sbjct: 929  QVPQFLFSSSNFIYLLFTTDNSRSNNGFK-IHYESVTVNTYSCLDP--GIPV--HGRRYG 983

Query: 3020 TDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFI---- 3075
             DF  G      C  G++L     + CE +  WS   P C+   CG     P+  I    
Sbjct: 984  HDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCD-ALCGGDVRGPSGTILSPG 1042

Query: 3076 -------SETSSWKENV-----ITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCG 3123
                   S   +W  +V     + ++  + ++      L+ TE G ++QP      L+  
Sbjct: 1043 YPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQP---LARLTGS 1099

Query: 3124 SPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCP- 3182
              P   NA   G         +LR +  +++  +    T  +         +  P + P 
Sbjct: 1100 DLPPTINAGLYG-----NFRAQLRFISDFSISYEGFNITFSE--------YNLEPCEDPG 1146

Query: 3183 LPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDG--TWEPPFSDESCSPVS 3240
            +P+  + I   G +F +   ++ SC+ GY  EG +  +C   G   W  P          
Sbjct: 1147 IPQYGSRI---GFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPR---CVAE 1200

Query: 3241 CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKET--- 3297
            CG   +   G ++   Y                E N E +     Q   G+ I   T   
Sbjct: 1201 CGASATNNEGILLSPNYPL------------NYENNHECIYSIQVQAGKGINISARTFHL 1248

Query: 3298 RCETPLEFLNGK---ADIENRTTGPNV----VYSCNRGYSLEGPSEAHCTENGTWSHPVP 3350
                 L+  +GK     +    TG ++    + S +    LE  S+   T+ G +     
Sbjct: 1249 AQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEG-FQLVYT 1307

Query: 3351 LCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDE--TWTQTS 3408
              + + C  P +      +S++  +    +   C  G+ L G  ++ C   E   W    
Sbjct: 1308 SFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPL 1367

Query: 3409 AKC 3411
              C
Sbjct: 1368 PSC 1370



 Score = 65.5 bits (158), Expect = 9e-10
 Identities = 68/272 (25%), Positives = 106/272 (38%), Gaps = 49/272 (18%)

Query: 3240 SCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRC 3299
            SC  P  P HG   G  ++  ST+ + C+ GY L      +C++N  WS  +  C +  C
Sbjct: 969  SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC-DALC 1027

Query: 3300 ETPL-------------EFLNGKADIE---NRTTGPNVVYSCNRGYSLEGPSEAHCTENG 3343
               +             EF     +     + T G  V ++ +  +  +       TENG
Sbjct: 1028 GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENG 1087

Query: 3344 TWSHPVPLCKPNPCPVPFVIPENALL-----SEKEFYVDQNVSIKCREGFLLQGHGIITC 3398
            +++ P+     +  P       NA L     ++  F  D ++S    EGF +        
Sbjct: 1088 SFTQPLARLTGSDLPPTI----NAGLYGNFRAQLRFISDFSISY---EGFNI-------- 1132

Query: 3399 NPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLE 3458
                    T ++     C  P   +     G ++  GD +T+SC SGY LEG    +CL 
Sbjct: 1133 --------TFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLG 1184

Query: 3459 NG--TWTSP-PICRAVCRFPCQNG-GICQRPN 3486
             G   W++P P C A C     N  GI   PN
Sbjct: 1185 GGRRVWSAPLPRCVAECGASATNNEGILLSPN 1216



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 75/307 (24%), Positives = 110/307 (35%), Gaps = 43/307 (14%)

Query: 307  CEKGYYGKGLQYECTACPSGTYKPEGSPGGIS---------SCIPCPDENHTSPPGSTSP 357
            C+   +  G Q  C+   +GT    G+PG  S         S +    +      GS   
Sbjct: 2995 CQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGS-EE 3053

Query: 358  EDCVCREGYRASGQTCELVHCPALKPPENG--YFIQNTCNNHFNAACGVRCHPGFDLVGS 415
              C+    +      C+ V C       NG  + I  T    F+++    C  G+ L G 
Sbjct: 3054 RTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTT---FSSSVIYSCMEGYILSGP 3110

Query: 416  SIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA------CDEG 469
            S+  C  NG WSG+   C + +C     P +G        + Y    +V       C  G
Sbjct: 3111 SVRQCTANGTWSGTLPNCTIISCGDPGIPANG--------LRYGDDYVVGQNVSYMCQPG 3162

Query: 470  YRLE--GSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFG---TI 524
            Y +E  GS   TC  N  W G  P C    C T   P  +     N   +   F    +I
Sbjct: 3163 YTMELNGSRIRTCTINGTWSGVMPTCRAVTCPT---PPQI----SNGRLEGTNFDWGFSI 3215

Query: 525  CYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSA 584
             Y+ C  G+ LS    +L C  +G W+  V   + K    P I      E K+   Q   
Sbjct: 3216 SYI-CSPGYELS-FPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEV 3273

Query: 585  NVTWQIP 591
            + +   P
Sbjct: 3274 SFSCNFP 3280



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 31/89 (34%), Positives = 39/89 (43%), Gaps = 4/89 (4%)

Query: 1789 CKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGE----WNHLIPYCKA 1844
            C  PG PENG   G  +++G+ V FSC E Y L G   ITC    E    W+   P CK 
Sbjct: 446  CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505

Query: 1845 VSCGKPAIPENGCIEELAFTFGSKVTYRC 1873
             +CG      +G      F F      +C
Sbjct: 506  KTCGSNLQGPSGTFTSPNFPFQYDSNAQC 534



 Score = 57.4 bits (137), Expect = 3e-07
 Identities = 56/208 (26%), Positives = 82/208 (39%), Gaps = 27/208 (12%)

Query: 361  VCRE---GYRASGQ---TCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVG 414
            VCR+   GY A       C+ + C   K P NG  +  T +          C+ G+ L  
Sbjct: 2569 VCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGIL--TTDYLVGTRVTYFCNDGYRLSS 2626

Query: 415  SSII--LCLPNGLWSGSESY--CRVRTCPHLRQ--PKHGH---ISCSTREMLYKTTCLVA 465
              +   +C  +G WS       C V TCP +     +HG    ++ S  E  YKT  + +
Sbjct: 2627 KELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYE--YKTKVVFS 2684

Query: 466  CDEGYRLEGSDKLTC--QGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGT 523
            CD GY   G   + C   G   W    P C    C     P     + +  G Q   +G+
Sbjct: 2685 CDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPP----NGNKIGTQ-TSYGS 2739

Query: 524  ICYVSCRQGFILSGVKEMLRCTTSGKWN 551
                +C  GF+L G   +  C +SG W+
Sbjct: 2740 TAIFTCDLGFMLVG-SAVRECLSSGLWS 2766



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 94/421 (22%), Positives = 147/421 (34%), Gaps = 52/421 (12%)

Query: 1905 CSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIEC----TASGIWDRAPPACHL 1960
            C  P    NGK I S  +  ST  +SCD  Y LQG   I C         W    P C +
Sbjct: 446  CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505

Query: 1961 VFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVS 2020
              CG          T  NF F+      C   + +  ++T + +        ++  L + 
Sbjct: 506  KTCGSNLQGPSGTFTSPNFPFQYDSNAQCV--WVITAVNTNKVIQ----INFEEFDLEIG 559

Query: 2021 CDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQ-GKWVPPEG--QDMPR 2077
             D   I D         +   +   +  D   ++ +SQ+  + Q  + V   G   +   
Sbjct: 560  YDTLTIGDGGEVGDPRTVLQVLTGSFVPD-LIVSMSSQMWLHLQTDESVGSVGFKVNYKE 618

Query: 2078 CIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPS-P 2136
                 C  P +  Y I E      F+   V+ F+C  GF L     I C    QW+ + P
Sbjct: 619  IEKESCGDPGTPLYGIREGDG---FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIP 675

Query: 2137 MSI-QCI-----PVRCGEPPSIMNGYASGSNYSF------GAMVAYSCNKGFYIKGEKKS 2184
            + I  C+     P+     P    GY +  N  +      G+ +  S N  F ++ +   
Sbjct: 676  ICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDF 734

Query: 2185 TCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFV 2244
                 G  S   P     +  E P        H T       + +Q +      G   F 
Sbjct: 735  LAVKDGD-SPESPILGTFTGAEVP-------SHLTSNSHILRLEFQADHSMSGRG---FN 783

Query: 2245 CQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGY-ELVGDSSWT 2303
               N   H+E P   +P+         N    G+NF++GS +   C EG+ +  G  + T
Sbjct: 784  ITYNTFGHNECPDPGIPI---------NARRFGDNFQLGSSISVICEEGFIKTQGTETIT 834

Query: 2304 C 2304
            C
Sbjct: 835  C 835



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 58/255 (22%), Positives = 94/255 (36%), Gaps = 38/255 (14%)

Query: 3241 CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQ----WSGGVAICKE 3296
            C  P  PE+G  +GS ++  ST+ + C+  Y L+G +   CQ   +    WS    +CK 
Sbjct: 446  CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505

Query: 3297 TRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNP 3356
              C + L+  +G        T PN        +  +  S A C    T  +   + + N 
Sbjct: 506  KTCGSNLQGPSG------TFTSPN--------FPFQYDSNAQCVWVITAVNTNKVIQINF 551

Query: 3357 CPVPFVIPENAL-LSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSA------ 3409
                  I  + L + +     D    ++   G  +    +I     + W           
Sbjct: 552  EEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVP--DLIVSMSSQMWLHLQTDESVGS 609

Query: 3410 --------KCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGT 3461
                    + EK SCG P      I  G  +   D++ + C  G+ L G    VC EN  
Sbjct: 610  VGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ 669

Query: 3462 WTSPPICRAVCRFPC 3476
            W++      +C FPC
Sbjct: 670  WSAN---IPICIFPC 681



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 23/59 (38%), Positives = 30/59 (50%), Gaps = 4/59 (6%)

Query: 1846 SCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANS----SWSHSPPVC 1900
            SCG P +P  G +    F  G K+ Y C  GY L G  + +C+ANS    SW    P+C
Sbjct: 137  SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 43/139 (30%), Positives = 55/139 (39%), Gaps = 17/139 (12%)

Query: 438  CPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQ----GNSQWDGPEPRC 493
            C     P HG+I   T   L  +    ACD G+RL G     C+    G   WD P P C
Sbjct: 2529 CSTPESPPHGYIISQTGGQL-NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2587

Query: 494  VERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQGFILSGVKEMLR--CTTSGK 549
                C    +PK    +P N G     +  GT     C  G+ LS  KE+    C + G 
Sbjct: 2588 QAISCG---IPK----APTNGGILTTDYLVGTRVTYFCNDGYRLSS-KELTTAVCQSDGT 2639

Query: 550  WNVGVQAAVCKDVEAPQIN 568
            W+   +   C  V  P IN
Sbjct: 2640 WSNHNKTPRCVVVTCPSIN 2658



 Score = 48.9 bits (115), Expect = 9e-05
 Identities = 24/61 (39%), Positives = 32/61 (52%), Gaps = 5/61 (8%)

Query: 3415 SCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLEN----GTWTSP-PICR 3469
            SCG P      +  G  +  GD I YSC +GY+L+G  +  C+ N     +W  P PICR
Sbjct: 137  SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196

Query: 3470 A 3470
            A
Sbjct: 197  A 197



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 54/251 (21%), Positives = 82/251 (32%), Gaps = 59/251 (23%)

Query: 1690 CGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTD----NGSWNGVSPSCLD 1745
            C  P   ENG     DF  GSTV + C+  Y L G   + C        +W+   P C  
Sbjct: 446  CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC-K 504

Query: 1746 VDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIY 1805
            V  C         ++     G++     P        C   I            ++ ++ 
Sbjct: 505  VKTCG--------SNLQGPSGTFTSPNFPFQYDSNAQCVWVI---------TAVNTNKVI 547

Query: 1806 TVGAEVTFSCQEGYQLMGV----------------------TKITCLESGEWNHL----- 1838
             +  E  F  + GY  + +                        I  + S  W HL     
Sbjct: 548  QINFE-EFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDES 606

Query: 1839 -------IPY--CKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLA 1889
                   + Y   +  SCG P  P  G  E   F+    + + C  G+ L G+K   C  
Sbjct: 607  VGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQE 666

Query: 1890 NSSWSHSPPVC 1900
            N+ WS + P+C
Sbjct: 667  NNQWSANIPIC 677



 Score = 45.8 bits (107), Expect = 8e-04
 Identities = 29/104 (27%), Positives = 43/104 (41%), Gaps = 6/104 (5%)

Query: 395  NNHFNAACG----VRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHIS 450
            NN F    G      C  G  L GS+   CLP+  WSG +  C   +C     P H ++ 
Sbjct: 3324 NNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANV- 3382

Query: 451  CSTREMLYKTTCLVACDEGYRLE-GSDKLTCQGNSQWDGPEPRC 493
                   +  T +  C  G+ L  G++   C+ ++ W G  P C
Sbjct: 3383 VGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3426



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 5/80 (6%)

Query: 1789 CKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCL----ESGEWNHLIPYCKA 1844
            C  PG P  G   G  + VG ++ +SC  GY L G  ++TC+     +  W+  +P C+A
Sbjct: 138  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197

Query: 1845 V-SCGKPAIPENGCIEELAF 1863
              +CG      +G I   +F
Sbjct: 198  EDACGGTMRGSSGIISSPSF 217



 Score = 43.9 bits (102), Expect = 0.003
 Identities = 26/90 (28%), Positives = 41/90 (45%), Gaps = 5/90 (5%)

Query: 2891 CATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSD----GNWDAEIPLCKP 2946
            C  P     GV  G  +    ++ + C  GYIL G P+LTC ++     +WD  +P+C+ 
Sbjct: 138  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197

Query: 2947 VN-CGPPEDLAHGFPNGFSFIHGGHIQYQC 2975
             + CG     + G  +  SF +  H    C
Sbjct: 198  EDACGGTMRGSSGIISSPSFPNEYHNNADC 227



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 22/75 (29%), Positives = 33/75 (44%), Gaps = 5/75 (6%)

Query: 2146 CGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEA----TGQWSSPIPTCHP 2201
            CG P     G   G+ +  G  + YSC  G+ + G  + TC A    T  W  P+P C  
Sbjct: 138  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197

Query: 2202 V-SCGEPPKVENGFL 2215
              +CG   +  +G +
Sbjct: 198  EDACGGTMRGSSGII 212



 Score = 42.7 bits (99), Expect = 0.006
 Identities = 23/65 (35%), Positives = 31/65 (47%), Gaps = 4/65 (6%)

Query: 1847 CGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCL----ANSSWSHSPPVCEP 1902
            C  P  PENG      F+ GS V + C++ Y L G K  +C       ++WS   PVC+ 
Sbjct: 446  CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505

Query: 1903 VKCSS 1907
              C S
Sbjct: 506  KTCGS 510



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 17/59 (28%), Positives = 28/59 (47%)

Query: 1686 ERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCL 1744
            E+ SCG P     G    D F     + ++C  G+ L+G+  + C +N  W+   P C+
Sbjct: 620  EKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICI 678



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 5/63 (7%)

Query: 3415 SCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCL-----ENGTWTSPPICR 3469
            SC  P ++ N    G+ Y+ G  +TY C +GY+L+G+    C+       G   + P C 
Sbjct: 1660 SCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH 1719

Query: 3470 AVC 3472
            A C
Sbjct: 1720 APC 1722



 Score = 41.6 bits (96), Expect = 0.014
 Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 2/54 (3%)

Query: 461  TCLVACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCVERHCSTFQMPKDVIISPH 512
            T   +C  GYRLEG+ ++ C G  +  W  P PRCV    ++    + +++SP+
Sbjct: 1163 TLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPN 1216



 Score = 41.2 bits (95), Expect = 0.019
 Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 3/61 (4%)

Query: 3415 SCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGT--WTSP-PICRAV 3471
            SC  P    + I  G  Y  GD++++ C  GY L+G     C+      W  P PIC A 
Sbjct: 2011 SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQ 2070

Query: 3472 C 3472
            C
Sbjct: 2071 C 2071



 Score = 40.8 bits (94), Expect = 0.024
 Identities = 21/66 (31%), Positives = 29/66 (43%), Gaps = 4/66 (6%)

Query: 3234 ESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQEN----RQWSG 3289
            E     SCG P  P  G + G+++     I Y C  GY L+G+ +  C  N      W  
Sbjct: 131  EELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190

Query: 3290 GVAICK 3295
             V IC+
Sbjct: 191  PVPICR 196



 Score = 39.3 bits (90), Expect = 0.071
 Identities = 18/47 (38%), Positives = 24/47 (51%), Gaps = 3/47 (6%)

Query: 1647 DLKPGSKVNLFCDPGFQLVGNPVQYCLN--QGQWTQPLPHCERISCG 1691
            D   G  ++  C PG+ L+GN    CL+     W  PLP CE + CG
Sbjct: 2199 DFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-CG 2244



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 24/86 (27%), Positives = 37/86 (43%), Gaps = 5/86 (5%)

Query: 3036 FKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYV 3095
            F L   S+    A G +   +   + +SCG+  + P   +  T     + I YSC +GY+
Sbjct: 111  FSLRLTSDFAVSAHG-FKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYI 169

Query: 3096 IQGSSDLICTEKGV----WSQPYPVC 3117
            + G   L C    V    W  P P+C
Sbjct: 170  LDGHPQLTCIANSVNTASWDFPVPIC 195



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 24/81 (29%), Positives = 33/81 (40%), Gaps = 10/81 (12%)

Query: 2714 SIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN----RKWSGASPR 2769
            S  C  P  P  G L  T   +G  ++YSC  G+IL G     C+ N      W    P 
Sbjct: 135  SSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194

Query: 2770 CEAISCKKPNPVMNGSIKGSN 2790
            C A           G+++GS+
Sbjct: 195  CRA------EDACGGTMRGSS 209



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 16/46 (34%), Positives = 22/46 (47%)

Query: 466 CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
           C  G+ L G   + CQ N+QW    P C+    S F  P   ++SP
Sbjct: 650 CQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSP 695



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 18/52 (34%), Positives = 24/52 (46%)

Query: 460  TTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
            +T   +CD GYRL   + L C+ N  W  P P C        + P   I+SP
Sbjct: 990  STVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSP 1041



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 4/99 (4%)

Query: 437  TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGN--SQWDGPEPRCV 494
            +CP  + P  G I    R M+        CD+GY L+G   +TC      +W+ P P C+
Sbjct: 2011 SCPEPQTPSSG-IKIGDRYMVGDVVSF-QCDQGYSLQGHSHITCMPGPVRRWNYPIPICL 2068

Query: 495  ERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGF 533
             +          VI+SP   G  P+       ++   GF
Sbjct: 2069 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGF 2107



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 18/58 (31%), Positives = 27/58 (46%), Gaps = 4/58 (6%)

Query: 2833 CSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLAN----GSWSGATPDC 2886
            C +P V   G + G  +    +I Y+C  G++L+G     C+AN     SW    P C
Sbjct: 138  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 21/57 (36%), Positives = 26/57 (45%), Gaps = 8/57 (14%)

Query: 2501 PKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCL----ETGDWDVDAPSCNA 2553
            PK +L G    T    G  + YSC  G+ L+G   LTC+     T  WD   P C A
Sbjct: 145  PKGVLYG----TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197



 Score = 37.4 bits (85), Expect = 0.27
 Identities = 24/80 (30%), Positives = 37/80 (46%), Gaps = 7/80 (8%)

Query: 438 CPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQ----WDGPEPRC 493
           CP   +P++G    S  +    +T   +CDE Y L+G+  +TCQ  ++    W    P C
Sbjct: 446 CPDPGEPENGKRIGS--DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503

Query: 494 VERHC-STFQMPKDVIISPH 512
             + C S  Q P     SP+
Sbjct: 504 KVKTCGSNLQGPSGTFTSPN 523



 Score = 37.4 bits (85), Expect = 0.27
 Identities = 18/59 (30%), Positives = 28/59 (47%), Gaps = 2/59 (3%)

Query: 363  REGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCL 421
            ++G+    Q  +L  CP  +P  NG+ I N             C PG+ L+G+S + CL
Sbjct: 2169 KQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFT--VGQTISFECFPGYTLIGNSALTCL 2225



 Score = 37.4 bits (85), Expect = 0.27
 Identities = 20/61 (32%), Positives = 26/61 (42%), Gaps = 3/61 (4%)

Query: 3415 SCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLE--NGTWTSP-PICRAV 3471
            SC  P    N    G  +  G  I++ C+ GY L G     CL   +  W  P P C A+
Sbjct: 2183 SCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL 2242

Query: 3472 C 3472
            C
Sbjct: 2243 C 2243



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 22/80 (27%), Positives = 35/80 (43%), Gaps = 10/80 (12%)

Query: 2771 EAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTC----QDDKNWDEDEP 2826
            ++ SC  P     G + G+ +     + Y C  GY+L+G  + TC     +  +WD   P
Sbjct: 134  QSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVP 193

Query: 2827 ICIPVDCSSPPVSANGQVRG 2846
            IC   D      +  G +RG
Sbjct: 194  ICRAED------ACGGTMRG 207



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 16/41 (39%), Positives = 21/41 (51%)

Query: 2264 CGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTC 2304
            CG P     G + G  F+VG K+++ C  GY L G    TC
Sbjct: 138  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTC 178



 Score = 36.2 bits (82), Expect = 0.60
 Identities = 20/65 (30%), Positives = 27/65 (41%), Gaps = 6/65 (9%)

Query: 2556 CDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTC-----EESGWSSSIPTCMP 2610
            C +P     G + G  +  G  I YSC  G+ + GH   TC       + W   +P C  
Sbjct: 138  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197

Query: 2611 ID-CG 2614
             D CG
Sbjct: 198  EDACG 202



 Score = 35.8 bits (81), Expect = 0.78
 Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 4/62 (6%)

Query: 3415 SCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCL--ENGTW--TSPPICRA 3470
            +C  P    N    G   + GD + + C  GY L+G  R  C+  EN  +   SPP+C A
Sbjct: 1487 ACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1546

Query: 3471 VC 3472
             C
Sbjct: 1547 PC 1548



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 4/65 (6%)

Query: 1689 SCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDN----GSWNGVSPSCL 1744
            SCG P     G      F  G  + Y C  GY L G  ++ C  N     SW+   P C 
Sbjct: 137  SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196

Query: 1745 DVDEC 1749
              D C
Sbjct: 197  AEDAC 201



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 15/40 (37%), Positives = 21/40 (52%), Gaps = 4/40 (10%)

Query: 3318 GPNVVYSCNRGYSLEGPSEAHCTEN----GTWSHPVPLCK 3353
            G  + YSC  GY L+G  +  C  N     +W  PVP+C+
Sbjct: 157  GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 18/52 (34%), Positives = 27/52 (51%), Gaps = 4/52 (7%)

Query: 464 VACDEGY-RLEGSDKLTC---QGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
           V C+EG+ + +G++ +TC    G   W G  P+C       F  P  VI+SP
Sbjct: 818 VICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSP 869



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 20/59 (33%), Positives = 25/59 (42%), Gaps = 4/59 (6%)

Query: 2948 NCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSN----GSWSGSSPSC 3002
            +CG P     G   G  F  G  I+Y C  GY L G+    C++N     SW    P C
Sbjct: 137  SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 25/79 (31%), Positives = 32/79 (40%), Gaps = 6/79 (7%)

Query: 3007 CSTP-VIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEAD----GQWSSGFPHCE- 3060
            C  P V   G + GT FD G   R  C  G+ L G  ++TC A+      W    P C  
Sbjct: 138  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197

Query: 3061 HTSCGSLPMIPNAFISETS 3079
              +CG      +  IS  S
Sbjct: 198  EDACGGTMRGSSGIISSPS 216



 Score = 34.7 bits (78), Expect = 1.7
 Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%)

Query: 364  EGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVR-CHPGFDLVGSSIILCL 421
            EG++    + EL HC     P+ GY I +    HF  +  +  C+PG+ L GSS++ C+
Sbjct: 1300 EGFQLVYTSFELSHCEDPGIPQFGYKISD--QGHFAGSTIIYGCNPGYTLHGSSLLKCM 1356



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 32/105 (30%), Positives = 41/105 (39%), Gaps = 15/105 (14%)

Query: 2203 SCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQAN----RHWHSESPLM 2258
            SCG P     G L  T   + + ++RY C  GY   G P   C AN      W    P+ 
Sbjct: 137  SCGNPGVPPKGVLYGTRFDVGD-KIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195

Query: 2259 CVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWT 2303
                 CG       G M+G +  + S    F NE Y    D +WT
Sbjct: 196  RAEDACG-------GTMRGSSGIISS--PSFPNE-YHNNADCTWT 230



 Score = 33.5 bits (75), Expect = 3.9
 Identities = 14/44 (31%), Positives = 21/44 (47%)

Query: 1963 CGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLAD 2006
            CG P      V+ G  F   + + Y+C  GY L G   + C+A+
Sbjct: 138  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIAN 181



 Score = 33.1 bits (74), Expect = 5.1
 Identities = 21/67 (31%), Positives = 28/67 (41%), Gaps = 5/67 (7%)

Query: 3355 NPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC----NPDETWTQTSAK 3410
            N CP P   PEN      +F +   V   C E ++LQG   ITC         W+     
Sbjct: 444  NLCPDPGE-PENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 502

Query: 3411 CEKISCG 3417
            C+  +CG
Sbjct: 503  CKVKTCG 509



 Score = 32.7 bits (73), Expect = 6.6
 Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 2/37 (5%)

Query: 460  TTCLVACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCV 494
            +T +  C+ GY L GS  L C    +  WD P P C+
Sbjct: 1335 STIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCI 1371



 Score = 32.3 bits (72), Expect = 8.6
 Identities = 26/104 (25%), Positives = 35/104 (33%), Gaps = 5/104 (4%)

Query: 1929 YSCDTGYSLQGPSIIECTASGI----WDRAPPACHLV-FCGEPPAIKDAVITGNNFTFRN 1983
            YSC TGY L G   + C A+ +    WD   P C     CG        +I+  +F    
Sbjct: 162  YSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEY 221

Query: 1984 TVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIV 2027
                 C         DTI  +            L +   EPP +
Sbjct: 222  HNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTI 265



 Score = 32.3 bits (72), Expect = 8.6
 Identities = 21/53 (39%), Positives = 26/53 (49%), Gaps = 6/53 (11%)

Query: 465 ACDEGYRLEGSDKLTCQGNS----QWDGPEPRC-VERHC-STFQMPKDVIISP 511
           +C  GY L+G  +LTC  NS     WD P P C  E  C  T +    +I SP
Sbjct: 163 SCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSP 215


>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
          Length = 3707

 Score =  521 bits (1341), Expect = e-147
 Identities = 391/1329 (29%), Positives = 559/1329 (42%), Gaps = 142/1329 (10%)

Query: 1789 CKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLE--SGEWNHLIPYCKAVS 1846
            C  P    NG   G  +TVG  ++F C  GY L+G + +TCL   S  WNH +P C+A+ 
Sbjct: 2224 CPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL- 2282

Query: 1847 CGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKC- 1905
            CG      NG I    +         C   + +     +    N +   + P+ + +   
Sbjct: 2283 CGGNITAMNGTIYSPGYPDEYPNFQDC--FWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2340

Query: 1906 SSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGE 1965
              P+  +      SG T L +  YS      ++  S  + T SG +  +  A  L  C  
Sbjct: 2341 DGPDQNSPQIGQFSGNTALESV-YSTSNQILIKFHS--DFTTSGFFVLSYHAYQLRVCQP 2397

Query: 1966 PPAIKDAVI--TGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDE 2023
            PP + +A I    + F   + + Y C  G+TL G   + C   G+  + D          
Sbjct: 2398 PPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRL-GERLQMD--------GA 2448

Query: 2024 PPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKW--VPPEGQDMPRCIAH 2081
            PP+     P    RL  D      S GY  +  +  +C     W     +G ++   +  
Sbjct: 2449 PPVCQVLCPANELRL--DSTGVILSPGYPDSYPNLQMC----AWSISVEKGYNITMFVEF 2502

Query: 2082 F-CEKP---------PSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQ 2131
            F  EK          P++   +L S+S    +A ++ S    E F+             Q
Sbjct: 2503 FQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITS-NGHEVFL-------------Q 2548

Query: 2132 W------NPSPMSIQCIPVRCGEPPSIMNGY-ASGSNYSFGAMVAYSCNKGFYIKGEKKS 2184
            W      N     I+ I   C  P S  +GY  S +     ++V ++C++GF + G+  +
Sbjct: 2549 WSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSA 2608

Query: 2185 TCEATG----QWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYK--SV 2238
             C  +      W +P+P C  +SCG P    NG +  TT  +  + V Y CN GY+  S 
Sbjct: 2609 VCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGI-LTTDYLVGTRVTYFCNDGYRLSSK 2667

Query: 2239 GSPVFVCQANRHW--HSESPLMCVPLDCGKPPPIQNGF---------MKGENFEVGSKVQ 2287
                 VCQ++  W  H+++P  CV + C    P  N F         + G ++E  +KV 
Sbjct: 2668 ELTTAVCQSDGTWSNHNKTP-RCVVVTC----PSINSFILEHGRWRIVNGSHYEYKTKVV 2722

Query: 2288 FFCNEGYELVGDSSWTCQKSGKWN-KKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVT 2346
            F C+ GY  +G +S  C  +G W+ +   P C    C E P   N   +   T+      
Sbjct: 2723 FSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAI 2782

Query: 2347 FSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKY 2406
            F+C  G +L G +V +CL S  W++S   C    C  P LI  G  I  +   +  TV Y
Sbjct: 2783 FTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGEN-YGYRDTVVY 2841

Query: 2407 SCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTC 2466
             C  GF L G+S  +CQ D  WS  LP CVPV C  P     G     G  +     ++C
Sbjct: 2842 QCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSC 2901

Query: 2467 KPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILN----GKFSYTDLHYGQTVTY 2522
              G+ + G T   C  N  W    P CK + C  P    N     K  + +  YG  V Y
Sbjct: 2902 NIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFY 2961

Query: 2523 SCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSC 2582
             CN G+ L G S L C   G WD   P C  I C  P    N  + G  Y++G+ + YSC
Sbjct: 2962 DCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSC 3021

Query: 2583 FPGFQVAGHAMQTCEESG-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMM 2641
                 + G + +TC+ +G WS S P C             GD T    D G         
Sbjct: 3022 TGKRSLLGQSSRTCQLNGHWSGSQPHCS------------GDATGTCGDPG--------- 3060

Query: 2642 EVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQE 2701
                                  T    +   SNF   + V Y C+ GY L G+    C  
Sbjct: 3061 ----------------------TPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLA 3098

Query: 2702 DGTWNGSAPSCISIECDLPTAPENG-FLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN 2760
            +G+W G  P C +++C  P    NG   R   T+  S+V YSC  G+IL+G  +R C  N
Sbjct: 3099 NGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTAN 3158

Query: 2761 RKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYV--LNGTERRTCQDD 2818
              WSG  P C  ISC  P    NG   G +Y     + Y C PGY   LNG+  RTC  +
Sbjct: 3159 GTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN 3218

Query: 2819 KNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGS 2878
              W    P C  V C +PP  +NG++ G  + +   I Y C+ G+ L       C+ NG+
Sbjct: 3219 GTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT 3278

Query: 2879 WSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWD 2938
            WSG  P C+P  C  P   A G  EG  + +  EV+F C+  +IL G+    CQ+DG W 
Sbjct: 3279 WSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWS 3338

Query: 2939 AEIPLC---KPVNCGPPEDLAHGFPNG-FSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGS 2994
               P C      +C  P    HG  N  F F  G  +Q+ C  G+ L G+++R CL + +
Sbjct: 3339 GSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLT 3398

Query: 2995 WSGSSPSCLPCRCSTP-VIEYGTVNGTDFDC-GKAARIQCFKGFKLLGLSE-ITCEADGQ 3051
            WSG  P C+P  C  P    +  V G D    G      C  GF L G +E   C +D  
Sbjct: 3399 WSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT 3458

Query: 3052 WSSGFPHCE 3060
            W+   P CE
Sbjct: 3459 WTGKVPICE 3467



 Score =  494 bits (1271), Expect = e-139
 Identities = 335/1075 (31%), Positives = 480/1075 (44%), Gaps = 119/1075 (11%)

Query: 2204 CGEPPKVENGFL-----EHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSE-SPL 2257
            C  PP V N  +     E   G I    +RYQC PG+  VG+ +  C+       + +P 
Sbjct: 2395 CQPPPPVPNAEILTEDDEFEIGDI----IRYQCLPGFTLVGNAILTCRLGERLQMDGAPP 2450

Query: 2258 MC---------------VPLDCGKPPPIQNGFMKG------ENFEVGSKVQFFCNEG--- 2293
            +C               V L  G P    N  M        + + +   V+FF  E    
Sbjct: 2451 VCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFD 2510

Query: 2294 ---------------YELVGD--SSWTCQKSG-----KW------NKKS-NPKCMPAKCP 2324
                             L GD  S++    +G     +W      NKK    + +   C 
Sbjct: 2511 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2570

Query: 2325 EPPLLENQLVLKELTTEVG-VVTFSCKEGHVLQGPSVLKCLPSQQ----WNDSFPVCKIV 2379
             P    +  ++ +   ++  VV ++C  G  L G S   C  S      W+   P C+ +
Sbjct: 2571 TPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAI 2630

Query: 2380 LCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGN--STTLCQPDGTWSS--PLPEC 2435
             C  P   + G  + +  L  G+ V Y C  G+ L     +T +CQ DGTWS+    P C
Sbjct: 2631 SCGIPKAPTNGGILTTDYL-VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRC 2689

Query: 2436 VPVECPQPEE--IPNG---IIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENG--HWLG 2488
            V V CP      + +G   I++     Y +  +++C PG+  +G  +  C  NG   W  
Sbjct: 2690 VVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRN 2749

Query: 2489 GKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDA 2548
             +P C+ I C +     NG    T   YG T  ++C+ GF L G +   CL +G W    
Sbjct: 2750 ERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESE 2809

Query: 2549 PSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEES-GWSSSIPT 2607
              C A HC  P+ I NG V G +Y Y   ++Y C PGF++ G +++ C++   WS  +P+
Sbjct: 2810 TRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPS 2869

Query: 2608 CMPIDCGLPPH----------IDFGDCTKLKDDQGYFEQEDD--MMEVPYVTPHPPYHLG 2655
            C+P+ CG P             +F D      + GY  Q       +      HPP    
Sbjct: 2870 CVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK 2929

Query: 2656 AVAKTWE----NTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPS 2711
             V  +      N+K        NF YGT+V Y CNPGY L G+ VLICQ +G W+   P 
Sbjct: 2930 VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPE 2989

Query: 2712 CISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCE 2771
            CI I+C  P  P N  L   + + GS V YSC     L G   R C  N  WSG+ P C 
Sbjct: 2990 CIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCS 3049

Query: 2772 AI---SCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPIC 2828
                 +C  P    +GS + SN+   ST+ Y CD GY+L+G+E RTC  + +W   +P C
Sbjct: 3050 GDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC 3109

Query: 2829 IPVDCSSPPVSANGQV-RGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCV 2887
              V C +P  +ANG+V R D  TF   + Y+C EG++L G   R C ANG+WSG  P+C 
Sbjct: 3110 KAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3169

Query: 2888 PVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYI--LHGAPKLTCQSDGNWDAEIPLCK 2945
             + C  P   ANG+  G DY   + V++ C  GY   L+G+   TC  +G W   +P C+
Sbjct: 3170 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR 3229

Query: 2946 PVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPC 3005
             V C  P  +++G   G +F  G  I Y C PGY+L   +   C+ NG+WSG  P CLP 
Sbjct: 3230 AVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPK 3289

Query: 3006 RCSTPVI-EYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHC---EH 3061
             C  P I   G   G  F         C   F L+G S   C+ADG WS   PHC     
Sbjct: 3290 FCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQ 3349

Query: 3062 TSCGSLPMIP------NAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYP 3115
            TSC + P +P      N F  +  S    V+ + C+ G+++QGS+   C     WS   P
Sbjct: 3350 TSCEN-PGVPRHGSQNNTFGFQVGS----VVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP 3404

Query: 3116 VCEPLSCGSPPSVANAVATG-EAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRW 3169
             C P SC  P + A+A   G +  ++   +   C  G+ +   T+   C+ D  W
Sbjct: 3405 ECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTW 3459



 Score =  458 bits (1178), Expect = e-128
 Identities = 327/1164 (28%), Positives = 486/1164 (41%), Gaps = 146/1164 (12%)

Query: 2372 SFPVCKIVLCTPPPLISFGVPIPSSAL-------HFGSTVKYSCVGGFFLRGNSTTLC-- 2422
            S+   ++ +C PPP      P+P++ +         G  ++Y C+ GF L GN+   C  
Sbjct: 2386 SYHAYQLRVCQPPP------PVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRL 2439

Query: 2423 ----QPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTT 2478
                Q DG      P    V CP  E              L +      PG+        
Sbjct: 2440 GERLQMDGA-----PPVCQVLCPANE------------LRLDSTGVILSPGYPDSYPNLQ 2482

Query: 2479 LCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTC 2538
            +C  +     G      +E  + ++    +F    ++ G  +          +  SA   
Sbjct: 2483 MCAWSISVEKGYNITMFVEFFQTEK----EFDVLQVYDGPNIQSPVLISLSGDYSSAFNI 2538

Query: 2539 LETG-----DWDVDAPSCN--------AIHCDSPQPIENGFV-EGADYSYGAIIIYSCFP 2584
               G      W  D  +          A +C +P+   +G++         +++ ++C  
Sbjct: 2539 TSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDR 2598

Query: 2585 GFQVAGHAMQTCEESG-----WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDD 2639
            GF++ G +   C +S      W + +P C  I CG+P                       
Sbjct: 2599 GFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPK---------------------- 2636

Query: 2640 MMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVL-- 2697
                       P + G +              ++++L GT V+Y CN GY L    +   
Sbjct: 2637 ----------APTNGGIL--------------TTDYLVGTRVTYFCNDGYRLSSKELTTA 2672

Query: 2698 ICQEDGTWNG--SAPSCISIECDLPTA--PENGFLRFTETS---MGSAVQYSCKPGHILA 2750
            +CQ DGTW+     P C+ + C    +   E+G  R    S     + V +SC PG+   
Sbjct: 2673 VCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGL 2732

Query: 2751 GSDLRLCLENRKWSGAS--PRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLN 2808
            G     CL N  WS  +  P C+ ISC +     NG+  G+  +Y ST  + CD G++L 
Sbjct: 2733 GPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLV 2792

Query: 2809 GTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGA 2868
            G+  R C     W E E  C+   C  P +  NGQV G+ Y ++  + Y CN GF L G+
Sbjct: 2793 GSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGS 2852

Query: 2869 RSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPK 2928
              R+C  + +WSG  P CVPV C  P     G T G  + F   VTF C+ GY++ G  K
Sbjct: 2853 SVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTK 2912

Query: 2929 LTCQSDGNWDAEIPLCKPVNCGPP---------EDLAHGFPNGFSFIHGGHIQYQCFPGY 2979
              CQ++  W    P+CK VNC  P           + HG     +F +G  + Y C PGY
Sbjct: 2913 AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHG-----NFTYGTVVFYDCNPGY 2967

Query: 2980 KLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTV-NGTDFDCGKAARIQCFKGFKL 3038
             L G+S   C  NG W    P C+   C  P +    V +G  +  G      C     L
Sbjct: 2968 FLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL 3027

Query: 3039 LGLSEITCEADGQWSSGFPHCEHTSCGSL--PMIPNAFISETSSWK-ENVITYSCRSGYV 3095
            LG S  TC+ +G WS   PHC   + G+   P  P     + S+++ ++ + Y+C +GY+
Sbjct: 3028 LGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYI 3087

Query: 3096 IQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANA-VATGEAHTYESEVKLRCLEGYTM 3154
            + GS +  C   G W+   P C+ + CG+P + AN  V   +  T+ S V   C+EGY +
Sbjct: 3088 LHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYIL 3147

Query: 3155 DTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFE 3214
             +      C  +G W     +C+   C  P    + L +GDD+ V + VS  C  GYT E
Sbjct: 3148 -SGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTME 3206

Query: 3215 --GVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYE 3272
              G  I  C ++GTW       +C  V+C  P    +G + G+ + +  +I Y C PGYE
Sbjct: 3207 LNGSRIRTCTINGTWSGVMP--TCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYE 3264

Query: 3273 LEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLE 3332
            L       C  N  WSG V  C    C  P     GK + ++      V +SCN  + L 
Sbjct: 3265 LSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILV 3324

Query: 3333 GPSEAHCTENGTWSHPVPLC---KPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFL 3389
            G S   C  +GTWS   P C       C  P V    +  +   F V   V   C++G L
Sbjct: 3325 GSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHL 3384

Query: 3390 LQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHY-QYGDMITYSCYSGYML 3448
            LQG    TC PD TW+    +C   SC  P    +A   G+    +G  + Y+C  G+ L
Sbjct: 3385 LQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFL 3444

Query: 3449 EGFL-RSVCLENGTWTSP-PICRA 3470
             G     VC  + TWT   PIC A
Sbjct: 3445 AGGTEHRVCRSDNTWTGKVPICEA 3468



 Score =  454 bits (1168), Expect = e-127
 Identities = 318/1171 (27%), Positives = 486/1171 (41%), Gaps = 162/1171 (13%)

Query: 1690 CGVPPPLENG--FHSADDFYAGSTVTYQCNNGYYLLGDSRMFCT--DNGSWNGVSPSC-- 1743
            C  PPP+ N       D+F  G  + YQC  G+ L+G++ + C   +    +G  P C  
Sbjct: 2395 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2454

Query: 1744 ------LDVDECAV---------GSDCSEHASCLNVDGSYICSCVPPY-----------T 1777
                  L +D   V           +    A  ++V+  Y  +    +            
Sbjct: 2455 LCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQV 2514

Query: 1778 GDGKNCAEPIKCKAPGN-------PENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCL 1830
             DG N   P+     G+         NGH   E++   +    + ++G+++  +      
Sbjct: 2515 YDGPNIQSPVLISLSGDYSSAFNITSNGH---EVFLQWSADHGNNKKGFRIRYI------ 2565

Query: 1831 ESGEWNHLIPYCKAVSCGKPAIPENG-CIEELAFTFGSKVTYRCNKGYTLAGDKESSCLA 1889
                         A  C  P  P +G  I +      S V + C++G+ L G   + C  
Sbjct: 2566 -------------AFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRK 2612

Query: 1890 NS----SWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIE- 1944
            +S    +W    P C+ + C  P+   NG  + +     +  +Y C+ GY L    +   
Sbjct: 2613 SSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTA 2672

Query: 1945 -CTASGIWD--RAPPACHLVFCGEPPAIKD--------AVITGNNFTFRNTVTYTCKEGY 1993
             C + G W      P C +V C   P+I           ++ G+++ ++  V ++C  GY
Sbjct: 2673 VCQSDGTWSNHNKTPRCVVVTC---PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGY 2729

Query: 1994 TLAGLDTIECLADGKWSRSDQQ--CLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGY 2051
               G  +IECL +G WS  +++  C  +SC E P   + +       +G  A + C  G+
Sbjct: 2730 HGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGF 2789

Query: 2052 SLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFK 2111
             L  ++   C + G W   E     RC+A  C  P  +   +   V    +     V ++
Sbjct: 2790 MLVGSAVRECLSSGLWSESE----TRCLAGHCGIPELI---VNGQVIGENYGYRDTVVYQ 2842

Query: 2112 CMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYS 2171
            C  GF L  S+   C +   W+    S  C+PV CG P S + G  SG+ ++F  +V +S
Sbjct: 2843 CNPGFRLIGSSVRICQQDHNWSGQLPS--CVPVSCGHPGSPIYGRTSGNGFNFNDVVTFS 2900

Query: 2172 CNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEP---------PKVENGFLEHTTGRI 2222
            CN G+ ++G  K+ C+A  QWS P P C  V+C +P          K+E+G   + T   
Sbjct: 2901 CNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGT--- 2957

Query: 2223 FESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEV 2282
                V Y CNPGY   GS V +CQ N  W    P  C+ +DCG P    N  + GE +  
Sbjct: 2958 ---VVFYDCNPGYFLFGSSVLICQPNGQWDKPLP-ECIMIDCGHPGVPPNAVLSGEKYTF 3013

Query: 2283 GSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKC---MPAKCPEPPLLENQLVLKELT 2339
            GS V + C     L+G SS TCQ +G W+  S P C       C +P    +    +   
Sbjct: 3014 GSTVHYSCTGKRSLLGQSSRTCQLNGHWS-GSQPHCSGDATGTCGDPGTPGHGSRQESNF 3072

Query: 2340 TEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALH 2399
                 V ++C  G++L G     CL +  W    P CK V C  P   + G         
Sbjct: 3073 RTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTT 3132

Query: 2400 FGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYL 2459
            F S+V YSC+ G+ L G S   C  +GTWS  LP C  + C  P    NG+         
Sbjct: 3133 FSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVG 3192

Query: 2460 STALYTCKPGF--ELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYG 2517
                Y C+PG+  EL G+    C  NG W G  PTC+A+ C  P +I NG+   T+  +G
Sbjct: 3193 QNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWG 3252

Query: 2518 QTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAI 2577
             +++Y C+ G+ L  P+ LTC+  G W  + P C    C  P     G  EG  + Y + 
Sbjct: 3253 FSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSE 3312

Query: 2578 IIYSCFPGFQVAGHAMQTCEESG-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQ 2636
            + +SC   F + G + + C+  G WS S P C+                         E 
Sbjct: 3313 VSFSCNFPFILVGSSTRICQADGTWSGSSPHCI-------------------------EP 3347

Query: 2637 EDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPV 2696
                 E P V  H                     ++  F  G++V + C  G+ L G+  
Sbjct: 3348 TQTSCENPGVPRH-----------------GSQNNTFGFQVGSVVQFHCKKGHLLQGSTT 3390

Query: 2697 LICQEDGTWNGSAPSCISIECDLPTAPEN-GFLRFTETSMGSAVQYSCKPGHILA-GSDL 2754
              C  D TW+G  P CI   C  P  P +   +     S G  + Y+C+PG  LA G++ 
Sbjct: 3391 RTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEH 3450

Query: 2755 RLCLENRKWSGASPRCEA---ISCKKPNPVM 2782
            R+C  +  W+G  P CEA   I  K P P +
Sbjct: 3451 RVCRSDNTWTGKVPICEAGSKILVKDPRPAL 3481



 Score =  437 bits (1123), Expect = e-121
 Identities = 285/926 (30%), Positives = 402/926 (43%), Gaps = 71/926 (7%)

Query: 1652 SKVNLFCDPGFQLVGNPVQYCLNQGQ----WTQPLPHCERISCGVPPPLENGFHSADDFY 1707
            S V   CD GF+LVG     C         W  P+P C+ ISCG+P    NG     D+ 
Sbjct: 2590 SVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYL 2649

Query: 1708 AGSTVTYQCNNGYYLLGD--SRMFCTDNGSWNG--VSPSCLDVDECAVGSDCSEHASCLN 1763
             G+ VTY CN+GY L     +   C  +G+W+    +P C+ V   ++ S   EH     
Sbjct: 2650 VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRI 2709

Query: 1764 VDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMG 1823
            V+GS+                                    Y    +V FSC  GY  +G
Sbjct: 2710 VNGSH------------------------------------YEYKTKVVFSCDPGYHGLG 2733

Query: 1824 VTKITCLESGEWN--HLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAG 1881
               I CL +G W+  +  PYC+ +SCG+   P NG       ++GS   + C+ G+ L G
Sbjct: 2734 PASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVG 2793

Query: 1882 DKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPS 1941
                 CL++  WS S   C    C  PE I NG+ I     Y  T  Y C+ G+ L G S
Sbjct: 2794 SAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSS 2853

Query: 1942 IIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTI 2001
            +  C     W    P+C  V CG P +      +GN F F + VT++C  GY + G    
Sbjct: 2854 VRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKA 2913

Query: 2002 ECLADGKWSRSDQQCLAVSCDEPPIVDHASPET----AHRLFGDIAFYYCSDGYSLADNS 2057
            +C A+ +WS     C  V+C +P I  ++  E+     +  +G + FY C+ GY L  +S
Sbjct: 2914 QCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSS 2973

Query: 2058 QLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFV 2117
             L+C   G+W  P    +P CI   C  P     ++L   S  K+  GS V + C     
Sbjct: 2974 VLICQPNGQWDKP----LPECIMIDCGHPGVPPNAVL---SGEKYTFGSTVHYSCTGKRS 3026

Query: 2118 LNTSAKIECMRGGQWNPS-PMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGF 2176
            L   +   C   G W+ S P         CG+P +  +G    SN+   + V Y+C+ G+
Sbjct: 3027 LLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGY 3086

Query: 2177 YIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYK 2236
             + G ++ TC A G W+   P C  V CG P    NG +    G  F S V Y C  GY 
Sbjct: 3087 ILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYI 3146

Query: 2237 SVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGY-- 2294
              G  V  C AN  W    P  C  + CG P    NG   G+++ VG  V + C  GY  
Sbjct: 3147 LSGPSVRQCTANGTWSGTLP-NCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTM 3205

Query: 2295 ELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGV-VTFSCKEGH 2353
            EL G    TC  +G W+    P C    CP PP + N   L+    + G  +++ C  G+
Sbjct: 3206 ELNGSRIRTCTINGTWSGVM-PTCRAVTCPTPPQISNGR-LEGTNFDWGFSISYICSPGY 3263

Query: 2354 VLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFF 2413
             L  P+VL C+ +  W+   P C    C  P + + G     S + + S V +SC   F 
Sbjct: 3264 ELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFI-YQSEVSFSCNFPFI 3322

Query: 2414 LRGNSTTLCQPDGTWSSPLPECV---PVECPQPEEIPNGI-IDVQGLAYLSTALYTCKPG 2469
            L G+ST +CQ DGTWS   P C+      C  P    +G   +  G    S   + CK G
Sbjct: 3323 LVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKG 3382

Query: 2470 FELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDL-HYGQTVTYSCNRGF 2528
              L G+TT  C  +  W G +P C    C +P+   +      DL  +G T+ Y+C  GF
Sbjct: 3383 HLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGF 3442

Query: 2529 RLEGPSA-LTCLETGDWDVDAPSCNA 2553
             L G +    C     W    P C A
Sbjct: 3443 FLAGGTEHRVCRSDNTWTGKVPICEA 3468



 Score =  379 bits (974), Expect = e-104
 Identities = 333/1226 (27%), Positives = 494/1226 (40%), Gaps = 154/1226 (12%)

Query: 2401 GSTVKYSCVGGFFLRGNSTTLCQP--DGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAY 2458
            G T+ + C  G+ L GNS   C       W+ PLP C  + C       NG I   G   
Sbjct: 2243 GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-CGGNITAMNGTIYSPGYPD 2301

Query: 2459 LSTALYTC------KPGFELVGNTTTLCGENGH-----WLGGKPTCKAIECLKPKEILNG 2507
                   C       PG  +  N T L  E  +     W G       I          G
Sbjct: 2302 EYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQI----------G 2351

Query: 2508 KFSYTDLHYGQTV---TYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIEN 2564
            +FS      G T     YS +    ++  S  T   +G + +   +     C  P P+ N
Sbjct: 2352 QFS------GNTALESVYSTSNQILIKFHSDFTT--SGFFVLSYHAYQLRVCQPPPPVPN 2403

Query: 2565 GFV--EGADYSYGAIIIYSCFPGFQVAGHAMQTC---EESGWSSSIPTCMPIDCGLPPHI 2619
              +  E  ++  G II Y C PGF + G+A+ TC   E      + P C  +    P + 
Sbjct: 2404 AEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVL---CPANE 2460

Query: 2620 DFGDCTKLKDDQGYFEQEDDMMEVPY-VTPHPPYHLGAVAKTWENTKESPATHSSNFLYG 2678
               D T +    GY +   ++    + ++    Y++    + ++  KE          + 
Sbjct: 2461 LRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----------FD 2510

Query: 2679 TMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSA 2738
             +  Y                  DG  N  +P  IS+  D  +A       F  TS G  
Sbjct: 2511 VLQVY------------------DGP-NIQSPVLISLSGDYSSA-------FNITSNGHE 2544

Query: 2739 V--QYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYL-S 2795
            V  Q+S   G+            N+K  G   R  A  C  P    +G I       L S
Sbjct: 2545 VFLQWSADHGN------------NKK--GFRIRYIAFYCSTPESPPHGYIISQTGGQLNS 2590

Query: 2796 TLYYECDPGYVLNGTERRTCQDDKN----WDEDEPICIPVDCSSPPVSANGQVRGDEYTF 2851
             + + CD G+ L G     C+        WD   P C  + C  P    NG +   +Y  
Sbjct: 2591 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLV 2650

Query: 2852 QKEIEYTCNEGFLLEGAR--SRVCLANGSWSG--ATPDCVPVRCATPPQ--LANG---VT 2902
               + Y CN+G+ L      + VC ++G+WS    TP CV V C +     L +G   + 
Sbjct: 2651 GTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIV 2710

Query: 2903 EGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWD--AEIPLCKPVNCGPPEDLAHGFP 2960
             G  Y +  +V F C  GY   G   + C  +G W    E P C+ ++CG      +G  
Sbjct: 2711 NGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNK 2770

Query: 2961 NGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTP-VIEYGTVNG 3019
             G    +G    + C  G+ L G++ R CLS+G WS S   CL   C  P +I  G V G
Sbjct: 2771 IGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIG 2830

Query: 3020 TDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETS 3079
             ++        QC  GF+L+G S   C+ D  WS   P C   SCG  P  P    +  +
Sbjct: 2831 ENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGH-PGSPIYGRTSGN 2889

Query: 3080 SWKEN-VITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAH 3138
             +  N V+T+SC  GY++QG +   C     WS P P+C+ ++C  P   AN+    +  
Sbjct: 2890 GFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIE 2949

Query: 3139 ----TYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHG 3194
                TY + V   C  GY +   +    CQ +G+W      C    C  P    + ++ G
Sbjct: 2950 HGNFTYGTVVFYDCNPGYFL-FGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSG 3008

Query: 3195 DDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTW---EPPFSDESCSPVSCGKPESPEHGF 3251
            + ++    V  SC    +  G +   CQL+G W   +P  S ++    +CG P +P HG 
Sbjct: 3009 EKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATG--TCGDPGTPGHGS 3066

Query: 3252 VVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKA- 3310
               S +  +ST+ Y C+ GY L G+ ER C  N  W+G    CK  +C  P    NGK  
Sbjct: 3067 RQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVF 3126

Query: 3311 DIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLS 3370
             I+  T   +V+YSC  GY L GPS   CT NGTWS  +P C    C  P  IP N L  
Sbjct: 3127 RIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPG-IPANGLRY 3185

Query: 3371 EKEFYVDQNVSIKCREGFLLQGHG--IITCNPDETWTQTSAKCEKISCGPPAHVENAIAR 3428
              ++ V QNVS  C+ G+ ++ +G  I TC  + TW+     C  ++C  P  + N    
Sbjct: 3186 GDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLE 3245

Query: 3429 GVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGI---CQRP 3485
            G ++ +G  I+Y C  GY L       C+ NGTW S  + + + +F C + GI    +R 
Sbjct: 3246 GTNFDWGFSISYICSPGYELSFPAVLTCVGNGTW-SGEVPQCLPKF-CGDPGIPAQGKRE 3303

Query: 3486 NACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGK 3545
                  +  +   C  P  ++         +   C     W+GS  H             
Sbjct: 3304 GKSFIYQSEVSFSCNFPFILVGS-------STRICQADGTWSGSSPH------------- 3343

Query: 3546 CVRPNRCHCLSSWTGHNCSRKRRTGF 3571
            C+ P +  C +     + S+    GF
Sbjct: 3344 CIEPTQTSCENPGVPRHGSQNNTFGF 3369



 Score =  330 bits (846), Expect = 2e-89
 Identities = 210/695 (30%), Positives = 297/695 (42%), Gaps = 42/695 (6%)

Query: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAGS 1710
            GS     CD GF LVG+ V+ CL+ G W++    C    CG+P  + NG    +++    
Sbjct: 2778 GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRD 2837

Query: 1711 TVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHAS--CLNVDGSY 1768
            TV YQCN G+ L+G S   C  + +W+G  PSC+ V     GS      S    N +   
Sbjct: 2838 TVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVV 2897

Query: 1769 ICSCVPPYTGDGKNCAE---------------PIKCKAPGNPENGHSSGEI----YTVGA 1809
              SC   Y   G   A+                + C  PG P N     +I    +T G 
Sbjct: 2898 TFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGT 2957

Query: 1810 EVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKV 1869
             V + C  GY L G + + C  +G+W+  +P C  + CG P +P N  +    +TFGS V
Sbjct: 2958 VVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTV 3017

Query: 1870 TYRCNKGYTLAGDKESSCLANSSWSHSPPVCE---PVKCSSPENINNGKYILSGLTYLST 1926
             Y C    +L G    +C  N  WS S P C       C  P    +G    S     ST
Sbjct: 3018 HYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKST 3077

Query: 1927 ASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDA-VITGNNFTFRNTV 1985
              Y+CDTGY L G     C A+G W    P C  V CG P    +  V   +  TF ++V
Sbjct: 3078 VRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSV 3137

Query: 1986 TYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFY 2045
             Y+C EGY L+G    +C A+G WS +   C  +SC +P I  +        + G    Y
Sbjct: 3138 IYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSY 3197

Query: 2046 YCSDGYSLADNSQLL--CNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFA 2103
             C  GY++  N   +  C   G W       MP C A  C  PP +S   LE  +   F 
Sbjct: 3198 MCQPGYTMELNGSRIRTCTINGTW----SGVMPTCRAVTCPTPPQISNGRLEGTN---FD 3250

Query: 2104 AGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYS 2163
             G  +S+ C  G+ L+  A + C+  G W  S    QC+P  CG+P     G   G ++ 
Sbjct: 3251 WGFSISYICSPGYELSFPAVLTCVGNGTW--SGEVPQCLPKFCGDPGIPAQGKREGKSFI 3308

Query: 2164 FGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTC---HPVSCGEPPKVENGFLEHTTG 2220
            + + V++SCN  F + G     C+A G WS   P C      SC  P    +G   +T G
Sbjct: 3309 YQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG 3368

Query: 2221 RIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENF 2280
                S V++ C  G+   GS    C  +  W    P  C+P  C +P    +  + G + 
Sbjct: 3369 FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP-ECIPHSCKQPETPAHANVVGMDL 3427

Query: 2281 -EVGSKVQFFCNEGYELVGDSSW-TCQKSGKWNKK 2313
               G  + + C  G+ L G +    C+    W  K
Sbjct: 3428 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGK 3462



 Score =  301 bits (772), Expect = 6e-81
 Identities = 193/638 (30%), Positives = 279/638 (43%), Gaps = 67/638 (10%)

Query: 1636 GSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPP 1695
            GS  + RT+         V   C+ G+ + G     C    QW+ P P C+ ++C  P  
Sbjct: 2879 GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGI 2938

Query: 1696 LENGFHSA----DDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAV 1751
              N    +     +F  G+ V Y CN GY+L G S + C  NG W+   P C+ +D    
Sbjct: 2939 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMID---- 2994

Query: 1752 GSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEV 1811
                                                 C  PG P N   SGE YT G+ V
Sbjct: 2995 -------------------------------------CGHPGVPPNAVLSGEKYTFGSTV 3017

Query: 1812 TFSCQEGYQLMGVTKITCLESGEWNHLIPYCK---AVSCGKPAIPENGCIEELAFTFGSK 1868
             +SC     L+G +  TC  +G W+   P+C      +CG P  P +G  +E  F   S 
Sbjct: 3018 HYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKST 3077

Query: 1869 VTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGK-YILSGLTYLSTA 1927
            V Y C+ GY L G +E +CLAN SW+   P C+ V+C +P    NGK + + G T+ S+ 
Sbjct: 3078 VRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSV 3137

Query: 1928 SYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTY 1987
             YSC  GY L GPS+ +CTA+G W    P C ++ CG+P    + +  G+++     V+Y
Sbjct: 3138 IYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSY 3197

Query: 1988 TCKEGYT--LAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFY 2045
             C+ GYT  L G     C  +G WS     C AV+C  PP + +   E  +  +G    Y
Sbjct: 3198 MCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISY 3257

Query: 2046 YCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAG 2105
             CS GY L+  + L C   G W      ++P+C+  FC  P   +    E  S   F   
Sbjct: 3258 ICSPGYELSFPAVLTCVGNGTW----SGEVPQCLPKFCGDPGIPAQGKREGKS---FIYQ 3310

Query: 2106 SVVSFKCMEGFVLNTSAKIECMRGGQWN-PSPMSIQCIPVRCGEPPSIMNGYASGS-NYS 2163
            S VSF C   F+L  S+   C   G W+  SP  I+     C  P    +G  + +  + 
Sbjct: 3311 SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQ 3370

Query: 2164 FGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIF 2223
             G++V + C KG  ++G    TC     WS   P C P SC +P   E     +  G   
Sbjct: 3371 VGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQP---ETPAHANVVGMDL 3427

Query: 2224 ESE---VRYQCNPGYKSVGSPVF-VCQANRHWHSESPL 2257
             S    + Y C PG+   G     VC+++  W  + P+
Sbjct: 3428 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPI 3465



 Score =  108 bits (269), Expect = 1e-22
 Identities = 312/1535 (20%), Positives = 502/1535 (32%), Gaps = 353/1535 (22%)

Query: 2102 FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWN-PSPMSIQCIPVRCGE---------PPS 2151
            F+ GS VSF C  G+ L+    + C +   W+ P P    C  +  G+          P 
Sbjct: 1026 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPT---CDALCGGDVRGPSGTILSPG 1082

Query: 2152 IMNGYASGSNYSFGAMVAYSCNKGF----YIKGEKKSTCEATGQWSSPIPTCHPVSCGEP 2207
                Y +  N ++   V +     F    +   +       T   S   P         P
Sbjct: 1083 YPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLP 1142

Query: 2208 PKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKP 2267
            P +  G   +     F +++R+  +      G  +   + N               C  P
Sbjct: 1143 PTINAGLYGN-----FRAQLRFISDFSISYEGFNITFSEYNLE------------PCEDP 1185

Query: 2268 PPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGK--WNKKSNPKCMPAKC-- 2323
               Q G   G NF +G  + F C+ GY L G S   C   G+  W+    P+C+ A+C  
Sbjct: 1186 GIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPL-PRCV-AECGA 1243

Query: 2324 -----------PEPPLL--ENQLVLKELTTEVGV-VTFSCKEGHVLQGPSV--------- 2360
                       P  PL    N   +  +  + G  +  S +  H+ QG  +         
Sbjct: 1244 SATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKT 1303

Query: 2361 ----------------LKCLPSQQW----------NDSFPVC----KIVLCTPPPLISFG 2390
                            L    +Q W          ++ F +     ++  C  P +  FG
Sbjct: 1304 THLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFG 1363

Query: 2391 VPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDG--TWSSPLPECVPVECPQPEEIPN 2448
              I       GST+ Y C  G+ L G+S   C       W  PLP C+     + +   +
Sbjct: 1364 YKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESS 1423

Query: 2449 GIIDVQGLAYLSTALYTCKPGFEL-VGNTTTLC-----GENGH-----WLGGKPTCKAIE 2497
            G I   G  +       C    E+  GN  +L       E  H     W G       ++
Sbjct: 1424 GRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLK 1483

Query: 2498 CLKPKEILNGKFSYTDLHYGQTVT--YSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIH 2555
             +    I  G  S  ++   Q  T  Y    GF ++  S++                A  
Sbjct: 1484 EISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSV----------------ATA 1527

Query: 2556 CDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG----WSSSIPTCMPI 2611
            C  P    NG   G     G  +++ C PG+++ G    TC +      W  S P C+  
Sbjct: 1528 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA- 1586

Query: 2612 DCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATH 2671
             CG            L    G+    +         PHP  H       W  T  +    
Sbjct: 1587 PCG----------GNLTGSSGFILSPN--------FPHPYPHSRDC--DWTITVNADYVI 1626

Query: 2672 SSNFLYGTMVSYTCNPGYELL--------GNPV---------------------LICQED 2702
            S  F     +S++  P Y+ L         +P+                     L  + D
Sbjct: 1627 SLAF-----ISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSD 1681

Query: 2703 GTWNGSA-----PSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLC 2757
            G+ + +       + +   C  P    NG     +  +GS V Y C  G++L G     C
Sbjct: 1682 GSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTC 1741

Query: 2758 LENRK----WSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYEC------DPGYVL 2807
            +        W+ A P C A  C   +    G++   NY    ++ + C         +V+
Sbjct: 1742 IMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVV 1800

Query: 2808 NGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTF----QKEIEYTCNEGF 2863
             G  +         D  E    P   SS   S +G   G+        Q  I +T     
Sbjct: 1801 FG--QFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPI 1858

Query: 2864 LLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYIL 2923
              +G              A P     +C++ P+   G   G ++     V F C+ GYIL
Sbjct: 1859 TAKGFHFVY--------QAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYIL 1910

Query: 2924 HGAPKLTCQSDGN----WDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGY 2979
            HG+  + C++  N    W+  +P C  V CG           G      G I     PGY
Sbjct: 1911 HGSIAIRCETVPNSLAQWNDSLPTC-IVPCG-----------GILTKRKGTI---LSPGY 1955

Query: 2980 KLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTD----FDCG--KAARIQCF 3033
                +++  C+    W  + P          V+ + T +  D    +D G   A R+  +
Sbjct: 1956 PEPYDNNLNCV----WKITVPE--GAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSY 2009

Query: 3034 KGFKLLGLSEITC-------EADGQWSSGFPHCEHTSCG----SLPMIPNAFISETSSWK 3082
             G  +  L   T        ++D   S+   H E+T+ G      P  P++ I     + 
Sbjct: 2010 SGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYM 2069

Query: 3083 -ENVITYSCRSGYVIQGSSDLICTEKGV--WSQPYPVCEPLSCGSPPSVANAVATGEAHT 3139
              +V+++ C  GY +QG S + C    V  W+ P P+C    CG   S  + V       
Sbjct: 2070 VGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC-LAQCGGAMSDFSGVILSPGFP 2128

Query: 3140 YESEVKLRC---------------------------LEGYTMDTDTDTFTCQKDGRWFPE 3172
                  L C                           LE  +  ++T T   +  G   P 
Sbjct: 2129 GNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPS 2188

Query: 3173 RISCSP---------------------------KKCPLPENITHILVHGDDFSVNRQVSV 3205
             +  +                            + CP P    +  V G+DF+V + +S 
Sbjct: 2189 SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISF 2248

Query: 3206 SCAEGYTFEGVNISVC--QLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTI 3263
             C  GYT  G +   C   +   W  P     C  + CG   +  +G +    Y  E   
Sbjct: 2249 ECFPGYTLIGNSALTCLHGVSRNWNHPL--PRCEAL-CGGNITAMNGTIYSPGYPDEYPN 2305

Query: 3264 IYQC------EPGYELEGN-----RERVCQENRQWSGGVAICKETRCETPLEFLNGKADI 3312
               C       PG  +  N      E +      W G        +    +   +G   +
Sbjct: 2306 FQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDG------PDQNSPQIGQFSGNTAL 2359

Query: 3313 ENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTW-----SHPVPLCKPNPCPVPFVIPENA 3367
            E+       VYS +    ++  S+   T +G +     ++ + +C+P P PVP       
Sbjct: 2360 ES-------VYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLRVCQPPP-PVP---NAEI 2406

Query: 3368 LLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDE 3402
            L  + EF +   +  +C  GF L G+ I+TC   E
Sbjct: 2407 LTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGE 2441



 Score =  107 bits (268), Expect = 2e-22
 Identities = 296/1393 (21%), Positives = 465/1393 (33%), Gaps = 236/1393 (16%)

Query: 1620 KIDSKSIFCSDCPRLGGSVP-HLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQW 1678
            KI  +S+  +    L   +P H R    D   GS V+  CD G++L       C     W
Sbjct: 997  KIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWW 1056

Query: 1679 TQPLPHCERISCG--VPPP----LENGFHSADDFYAGS-------TVTY----QCNNGYY 1721
            + PLP C+ + CG  V  P    L  G+    +FY  S        VT+    Q N   +
Sbjct: 1057 SHPLPTCDAL-CGGDVRGPSGTILSPGY---PEFYPNSLNCTWTVDVTHGKGVQFNFHTF 1112

Query: 1722 LLGDSR--MFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASC-----LNVDGSYICSCVP 1774
             L D    +  T+NGS+               GSD     +            +I     
Sbjct: 1113 HLEDHHDYLLITENGSFTQPLAR-------LTGSDLPPTINAGLYGNFRAQLRFISDFSI 1165

Query: 1775 PYTGDGKNCAE--PIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLES 1832
             Y G     +E     C+ PG P+ G   G  + +G  +TFSC  GY+L G ++I CL  
Sbjct: 1166 SYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGG 1225

Query: 1833 GE--WNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLAN 1890
            G   W+  +P C A  CG  A    G +    +    +  + C     +   K  +  A 
Sbjct: 1226 GRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISAR 1284

Query: 1891 SSWSHSPPVCEPVKCSSPENINNGKYI---LSGLTYLSTASYSCDTGYSLQGPSIIECTA 1947
            +       V +            G +    + GLT  ST++        L+  S  E T 
Sbjct: 1285 TFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQ-----LWLEFNSDTEGTD 1339

Query: 1948 SGIWDRAPPACHLVFCGEP--PAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLA 2005
             G +     +  L  C +P  P     +    +F   +T+ Y C  GYTL G   ++C+ 
Sbjct: 1340 EG-FQLVYTSFELSHCEDPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMT 1397

Query: 2006 DGK--WSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNA 2063
              +  W      C+A              E   R  G+ +    S GY    ++ L C  
Sbjct: 1398 GERRAWDYPLPSCIA--------------ECGGRFKGESSGRILSPGYPFPYDNNLRCMW 1443

Query: 2064 QGKWVPPEGQDMPRCIAHFCEKPPSVSYSIL-------ESVSKAKFAAGSVVSFKCMEGF 2116
              +  P     +      F       S+ IL       E+    K  +GS++     EG 
Sbjct: 1444 MIEVDPGNIVSL-----QFLAFDTEASHDILRVWDGPPENDMLLKEISGSLIP----EGI 1494

Query: 2117 --VLNTSAKIECMRGGQWNPSPMSIQ---CIPVRCGEPPSIMNGYASGSNYSFGAMVAYS 2171
               LN    I+       + S  +IQ    +   C +P   MNG  +G     G  V + 
Sbjct: 1495 HSTLNI-VTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQ 1553

Query: 2172 CNKGFYIKGEKKSTC---EATGQWSSPIPTCHPVSCGEPPKVENGFL-----EHTTGRIF 2223
            C+ G+ ++GE++ TC   E    W    P C    CG      +GF+      H      
Sbjct: 1554 CDPGYELQGEERITCIQVENRYFWQPSPPVC-IAPCGGNLTGSSGFILSPNFPHPYPHSR 1612

Query: 2224 ESEVRYQCNPGYK-SVGSPVFVCQANRHW-------HSESPLMCVPLDCGKPPPIQNGFM 2275
            + +     N  Y  S+    F  + N  +        S SPL+    D   P        
Sbjct: 1613 DCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLP-------- 1664

Query: 2276 KGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVL 2335
              E  E  S            V  + +  +   K         +   C +P  + N   L
Sbjct: 1665 --ERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK---------LRESCFDPGNIMNGTRL 1713

Query: 2336 KELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQ----WNDSFPVC-------------KI 2378
                     VT+ C  G+VLQG S L C+        WN + P C              +
Sbjct: 1714 GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTV 1773

Query: 2379 VLCTPPPLISFG------VPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDG-TWSSP 2431
            +    P   S G      + +P   + FG  V       FF       +   DG T  S 
Sbjct: 1774 LSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFV-------FFQTSLHDVVEVYDGPTQQSS 1826

Query: 2432 LPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKP 2491
            L   +       E +P    +   + + S    T K GF  V                 P
Sbjct: 1827 LLSSLS-GSHSGESLPLSSGNQITIRFTSVGPITAK-GFHFVYQAV-------------P 1871

Query: 2492 TCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLET-----GDWDV 2546
               + +C    E   G+    +   G +V + CN G+ L G  A+ C ET       W+ 
Sbjct: 1872 RTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRC-ETVPNSLAQWND 1930

Query: 2547 DAPSCNAIHCD------SPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG 2600
              P+C  + C           +  G+ E  D +   +   +   G  +    +    E  
Sbjct: 1931 SLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN 1989

Query: 2601 WSS---------SIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPP 2651
            W S         + P          PH+       L     Y   + D+           
Sbjct: 1990 WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNL-----YLNFQSDIS-----VSAAG 2039

Query: 2652 YHLGAVAKTWENTKESPATHSS------NFLYGTMVSYTCNPGYELLGNPVLICQEDGT- 2704
            +HL   A   ++  E P T SS       ++ G +VS+ C+ GY L G+  + C      
Sbjct: 2040 FHLEYTAIGLDSCPE-PQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVR 2098

Query: 2705 -WNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCK-PGHILAGSDLRLCLENRK 2762
             WN   P C++ +C    +  +G +              C    ++  G  + L   N  
Sbjct: 2099 RWNYPIPICLA-QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFS 2157

Query: 2763 WSGASPRCEAISCKKPNPVMNGSIKGS-------NYTYLSTLYYECDPGYVLNGTERRTC 2815
                    E  S       + G + G        + T+ ++LY+  D             
Sbjct: 2158 TETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSD-----------YS 2206

Query: 2816 QDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCL- 2874
            Q+ + +           C  P    NG V G+++T  + I + C  G+ L G  +  CL 
Sbjct: 2207 QNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLH 2266

Query: 2875 -ANGSWSGATPDC 2886
              + +W+   P C
Sbjct: 2267 GVSRNWNHPLPRC 2279



 Score =  105 bits (261), Expect = 1e-21
 Identities = 253/1208 (20%), Positives = 414/1208 (34%), Gaps = 286/1208 (23%)

Query: 2264 CGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGK----WNKKSNPKCM 2319
            C  P   +NG   G +F +GS VQF C+E Y L G  S TCQ+  +    W+    P C 
Sbjct: 486  CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWS-DHRPVCK 544

Query: 2320 PAKC-------------PEPPLLEN------------------QLVLKELTTEVGVVTFS 2348
               C             P  P   +                  Q+  +E   E+G  T +
Sbjct: 545  VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 604

Query: 2349 CKEG----------HVLQG---PSVLKCLPSQQW--------------NDSFPVCKIVLC 2381
              +G           VL G   P ++  + SQ W                ++   +   C
Sbjct: 605  IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 664

Query: 2382 TPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECP 2441
              P    +G+            +++ C  GF L G  + +CQ +  WS+ +P C+   C 
Sbjct: 665  GDPGTPLYGIR-EGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICI-FPCL 722

Query: 2442 QPEEIPNGII----DVQGLAYLSTALYT--CKPG---------FELVGNTTTLCGENGHW 2486
                 P G +      +G       ++T    PG         F+L      L  ++G  
Sbjct: 723  SNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD- 781

Query: 2487 LGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDV 2546
                          P+  + G F+  ++    T   S +   RLE  +  +    G +++
Sbjct: 782  -------------SPESPILGTFTGAEVPSHLT---SNSHILRLEFQADHSMSGRG-FNI 824

Query: 2547 DAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGF-QVAGHAMQTC----EESGW 2601
               +     C  P    N    G ++  G+ I   C  GF +  G    TC     +  W
Sbjct: 825  TYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMW 884

Query: 2602 SSSIPTC-------------------------MPIDCGLPPHIDFGDCTKLKDDQGYFEQ 2636
            S  IP C                           ++C      + G   K+  ++   E 
Sbjct: 885  SGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTEL 944

Query: 2637 EDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHS-SNFLY--GTMVSYTCNPGYELLG 2693
              D++EV       P  L  +  ++  T+      S SNF+Y   T  +   N G+++  
Sbjct: 945  NYDVLEV----HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHY 1000

Query: 2694 NPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSD 2753
              V +         +  SC+      P  P +G     + S+GS V +SC  G+ L+  +
Sbjct: 1001 ESVTV---------NTYSCLD-----PGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEE 1046

Query: 2754 LRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPG-----YVLN 2808
              LC +N  WS   P C+A+          G ++G + T LS  Y E  P      + ++
Sbjct: 1047 PLLCEKNHWWSHPLPTCDAL--------CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVD 1098

Query: 2809 GTERRTCQDD----------------KNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQ 2852
             T  +  Q +                +N    +P+        PP + N  + G+   F+
Sbjct: 1099 VTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPP-TINAGLYGN---FR 1154

Query: 2853 KEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKE 2912
             ++ +  +     EG        N              C  P     G   G ++G    
Sbjct: 1155 AQLRFISDFSISYEGFNITFSEYNLE-----------PCEDPGIPQYGSRIGFNFGIGDT 1203

Query: 2913 VTFHCHEGYILHGAPKLTCQSDGN--WDAEIPLCKPVNCGPPED------LAHGFPNGFS 2964
            +TF C  GY L G  ++ C   G   W A +P C    CG          L+  +P  + 
Sbjct: 1204 LTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC-VAECGASATNNEGILLSPNYPLNYE 1262

Query: 2965 FIHG--GHIQYQCFPG---------------YKLHGNSSRRCLSNGSWSGSSPSCLPCRC 3007
              H     IQ Q   G                K++    +     G+++G+S   L    
Sbjct: 1263 NNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSS 1322

Query: 3008 STPV--IEYGT-VNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSC 3064
            ++    +E+ +   GTD            +GF+L+             S    HCE    
Sbjct: 1323 TSNQLWLEFNSDTEGTD------------EGFQLV-----------YTSFELSHCED--- 1356

Query: 3065 GSLPMIP--NAFISETSSWKENVITYSCRSGYVIQGSSDLICT--EKGVWSQPYPVCEPL 3120
               P IP     IS+   +  + I Y C  GY + GSS L C   E+  W  P P C   
Sbjct: 1357 ---PGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE 1413

Query: 3121 SCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPE------RI 3174
              G     ++       + +  +  LRC+  + ++ D       +   +  E      R+
Sbjct: 1414 CGGRFKGESSGRILSPGYPFPYDNNLRCM--WMIEVDPGNIVSLQFLAFDTEASHDILRV 1471

Query: 3175 SCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTW---EPPF 3231
               P     PEN   +          +++S S         +NI   Q D  +   +  F
Sbjct: 1472 WDGP-----PENDMLL----------KEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGF 1516

Query: 3232 SDESCSPV--SCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVC--QENRQ- 3286
            + +  S V  +C  P  P +G   G       T+++QC+PGYEL+G     C   ENR  
Sbjct: 1517 AIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYF 1576

Query: 3287 WSGGVAIC 3294
            W     +C
Sbjct: 1577 WQPSPPVC 1584



 Score = 89.7 bits (221), Expect = 5e-17
 Identities = 73/289 (25%), Positives = 117/289 (40%), Gaps = 41/289 (14%)

Query: 307  CEKGYYGKG-LQYECTACPSGTYKPEGSPGGISSC--IPCPDENHT----SPPGSTS--- 356
            C+ GY+G G    EC    + +++ E     I SC  +P P   +     +  GST+   
Sbjct: 2725 CDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFT 2784

Query: 357  -----------PEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVR 405
                         +C+    +  S   C   HC   +   NG  I    N  +      +
Sbjct: 2785 CDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGE--NYGYRDTVVYQ 2842

Query: 406  CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA 465
            C+PGF L+GSS+ +C  +  WSG    C   +C H   P +G    S     +      +
Sbjct: 2843 CNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGR--TSGNGFNFNDVVTFS 2900

Query: 466  CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAK----- 520
            C+ GY ++G  K  CQ N QW  P P C   +CS   +P +         K+ +K     
Sbjct: 2901 CNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPAN--------SKRESKIEHGN 2952

Query: 521  --FGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQI 567
              +GT+ +  C  G+ L G   +L C  +G+W+  +   +  D   P +
Sbjct: 2953 FTYGTVVFYDCNPGYFLFG-SSVLICQPNGQWDKPLPECIMIDCGHPGV 3000



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 139/641 (21%), Positives = 224/641 (34%), Gaps = 119/641 (18%)

Query: 1698 NGFHSADDFYAGSTVTYQCNNGYYLL-GDSRMFCT---DNGSWNGVSPSCLDVDECAVGS 1753
            N     D+F  GS+++  C  G+    G   + C        W+G+ P C        G+
Sbjct: 842  NARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC--------GA 893

Query: 1754 DCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNP----------ENGHSSGE 1803
             C  H S  +  G  +    P Y  D  NC   I+ + PG+           E  +   E
Sbjct: 894  PCGGHFSAPS--GVILSPGWPGYYKDSLNCEWVIEAE-PGHSIKITFERFQTELNYDVLE 950

Query: 1804 IY---------------TVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYC-KAVSC 1847
            ++               T   +  FS      L+  T  +   +G   H         SC
Sbjct: 951  VHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 1010

Query: 1848 GKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSS 1907
              P IP +G      F+ GS V++ C+ GY L+ ++   C  N  WSH  P C+ + C  
Sbjct: 1011 LDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL-CGG 1069

Query: 1908 PENINNGKYILSG----------------LTYLSTASYSCDTGYSLQGPSIIECTASGIW 1951
                 +G  +  G                +T+     ++  T +       +  T +G +
Sbjct: 1070 DVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSF 1129

Query: 1952 DRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSR 2011
             +  P   L     PP I +A + GN   FR  + +      +  G +            
Sbjct: 1130 TQ--PLARLTGSDLPPTI-NAGLYGN---FRAQLRFISDFSISYEGFNI----------- 1172

Query: 2012 SDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGK--WVP 2069
            +  +     C++P I  + S    +   GD   + CS GY L   S+++C   G+  W  
Sbjct: 1173 TFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSA 1232

Query: 2070 PEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRG 2129
            P    +PRC+A  C    + +  IL S                   + LN     EC+  
Sbjct: 1233 P----LPRCVAE-CGASATNNEGILLS-----------------PNYPLNYENNHECIYS 1270

Query: 2130 GQWNPSP---MSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKG------ 2180
             Q        +S +   +  G+   I +G    + +  GA    S  +G  +        
Sbjct: 1271 IQVQAGKGINISARTFHLAQGDVLKIYDG-KDKTTHLLGAFTGASM-RGLTLSSTSNQLW 1328

Query: 2181 -EKKSTCEATGQWSSPIPTCHPVS-CGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSV 2238
             E  S  E T +    + T   +S C +P   + G+     G    S + Y CNPGY   
Sbjct: 1329 LEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLH 1388

Query: 2239 GSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGEN 2279
            GS +  C        + PL     +CG       G  KGE+
Sbjct: 1389 GSSLLKCMTGERRAWDYPLPSCIAECG-------GRFKGES 1422



 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 252/1237 (20%), Positives = 409/1237 (33%), Gaps = 316/1237 (25%)

Query: 2203 SCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPL----- 2257
            SCG+P     G  E   G      +R++C  G++ +G    VCQ N  W +  P+     
Sbjct: 663  SCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 721

Query: 2258 ---MCVPLDCGKPPPIQNGFMKGEN------FEVGSKVQFFCNEGYELVGDSSWTCQKSG 2308
                  P+     P    G+    N       + GS++    N+ ++L     +   K G
Sbjct: 722  LSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFND-FDLESQFDFLAVKDG 780

Query: 2309 KWNKKSNPKCMPAKCPEPPLL---ENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLP 2365
                           PE P+L       V   LT+   ++    +  H + G        
Sbjct: 781  -------------DSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSG-------- 819

Query: 2366 SQQWNDSFPVCKIVLCTPPPLISFGVPIPS----SALHFGSTVKYSCVGGFF-LRGNSTT 2420
             + +N ++       C  P     G+PI +         GS++   C  GF   +G  T 
Sbjct: 820  -RGFNITYNTFGHNECPDP-----GIPINARRFGDNFQLGSSISVICEEGFIKTQGTETI 873

Query: 2421 LC-QPDG--TWSSPLPECVPVECPQPEEIPNGIIDVQGL-AYLSTAL-----YTCKPG-- 2469
             C   DG   WS  +P+C    C      P+G+I   G   Y   +L        +PG  
Sbjct: 874  TCILMDGKVMWSGLIPKC-GAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHS 932

Query: 2470 -------FELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTY 2522
                   F+   N   L   +G  L   P   +    +  + L    ++  L +  T   
Sbjct: 933  IKITFERFQTELNYDVLEVHDGPNL-LSPLLGSYNGTQVPQFLFSSSNFIYLLF-TTDNS 990

Query: 2523 SCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSC 2582
              N GF++                ++ + N   C  P    +G   G D+S G+ + +SC
Sbjct: 991  RSNNGFKIH--------------YESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSC 1036

Query: 2583 FPGFQVAGHAMQTCEES-GWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMM 2641
              G++++      CE++  WS  +PTC  + CG       GD   ++   G         
Sbjct: 1037 DSGYRLSHEEPLLCEKNHWWSHPLPTCDAL-CG-------GD---VRGPSG--------- 1076

Query: 2642 EVPYVTP-HPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQ 2700
                ++P +P ++  ++  TW          + +  +G  V +  +  +    +  L+  
Sbjct: 1077 --TILSPGYPEFYPNSLNCTW----------TVDVTHGKGVQFNFHTFHLEDHHDYLLIT 1124

Query: 2701 EDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN 2760
            E+G++  + P       DLP     G              Y      +   SD  +  E 
Sbjct: 1125 ENGSF--TQPLARLTGSDLPPTINAGL-------------YGNFRAQLRFISDFSISYEG 1169

Query: 2761 RKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDD-- 2818
               + +    E   C+ P     GS  G N+    TL + C  GY L GT    C     
Sbjct: 1170 FNITFSEYNLE--PCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGR 1227

Query: 2819 KNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTC------------------- 2859
            + W    P C+  +C +   +  G +    Y    E  + C                   
Sbjct: 1228 RVWSAPLPRCV-AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTF 1286

Query: 2860 --NEGFLLE--GARSRVCLANGSWSGATPDCVPVRCATPPQL---ANGVTEGLDYGFMKE 2912
               +G +L+    + +     G+++GA+   + +  +T  QL    N  TEG D GF   
Sbjct: 1287 HLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTL-SSTSNQLWLEFNSDTEGTDEGFQLV 1345

Query: 2913 VT----FHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHG 2968
             T     HC +  I     K++ Q                         G   G + I+G
Sbjct: 1346 YTSFELSHCEDPGIPQFGYKISDQ-------------------------GHFAGSTIIYG 1380

Query: 2969 GHIQYQCFPGYKLHGNSSRRCLS--NGSWSGSSPSCL-PC----------RCSTPVIEYG 3015
                  C PGY LHG+S  +C++    +W    PSC+  C          R  +P   + 
Sbjct: 1381 ------CNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFP 1434

Query: 3016 TVNG------TDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPM 3069
              N        + D G    +Q F  F      +I    DG   +            L  
Sbjct: 1435 YDNNLRCMWMIEVDPGNIVSLQ-FLAFDTEASHDILRVWDGPPENDM---------LLKE 1484

Query: 3070 IPNAFISETSSWKENVIT-------YSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSC 3122
            I  + I E      N++T       Y  +SG+ IQ SS +                  +C
Sbjct: 1485 ISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSV----------------ATAC 1528

Query: 3123 GSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCP 3182
              P    N    G+       V  +C  GY +  +      Q + R+F +    SP  C 
Sbjct: 1529 RDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQP---SPPVCI 1585

Query: 3183 LP--------------ENITHILVHGDD----FSVNRQVSVSCA-----------EGYTF 3213
             P               N  H   H  D     +VN    +S A             Y +
Sbjct: 1586 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1645

Query: 3214 EGVNISVCQLDGTWEP---PFSDESCSPV--------------------------SCGKP 3244
            +G + S   L G+++    P   ES S                            SC  P
Sbjct: 1646 DGPD-SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP 1704

Query: 3245 ESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVC 3281
             +  +G  +G  Y   ST+ Y C+ GY L+G     C
Sbjct: 1705 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTC 1741



 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 107/435 (24%), Positives = 159/435 (36%), Gaps = 83/435 (19%)

Query: 1632 PRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCL----NQGQWTQPLPHC-- 1685
            PR G      R    +   GS V   C+PG+ L G+    C     +  QW   LP C  
Sbjct: 1884 PRFG------RRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIV 1937

Query: 1686 -----------ERISCGVPPPLENGFHSADDFYA--GSTVTYQCNN----------GYYL 1722
                         +S G P P +N  +         G+ +  Q  +           +Y 
Sbjct: 1938 PCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYD 1997

Query: 1723 LGDSRMFCTDNGSWNGVS-PSCLDVDECAV----GSDCSEHASCLNVDGSYICSCVPPYT 1777
             GD+       GS++G + P  L+     +     SD S  A+  +++          YT
Sbjct: 1998 GGDNN--APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLE----------YT 2045

Query: 1778 GDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLES--GEW 1835
              G +      C  P  P +G   G+ Y VG  V+F C +GY L G + ITC+      W
Sbjct: 2046 AIGLD-----SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 2100

Query: 1836 NHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTL-AGDKESSCLANSSWS 1894
            N+ IP C A  CG      +G I    F      +  C     L  G        N S  
Sbjct: 2101 NYPIPICLA-QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE 2159

Query: 1895 HSPPVCEPVKCSSPENIN-----NGKYILSGL---TYLSTASYSCDTGYSLQGPSIIECT 1946
                  E V+  S E        +G  I S L   T+ ++  +  D   + QG  I+   
Sbjct: 2160 TIHDYLE-VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVY-- 2216

Query: 1947 ASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECL-- 2004
                      A  L  C +P   ++  + GN+FT   T+++ C  GYTL G   + CL  
Sbjct: 2217 ---------QAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHG 2267

Query: 2005 ADGKWSRSDQQCLAV 2019
                W+    +C A+
Sbjct: 2268 VSRNWNHPLPRCEAL 2282



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 49/157 (31%), Positives = 65/157 (41%), Gaps = 10/157 (6%)

Query: 398  FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCR---VRTCPHLRQPKHGHISCSTR 454
            F +     C     L+G S   C  NG WSGS+ +C      TC     P HG  S    
Sbjct: 3013 FGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG--SRQES 3070

Query: 455  EMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNC 514
                K+T   ACD GY L GS++ TC  N  W G +P C    C           +    
Sbjct: 3071 NFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGN----PGTTANGKVF 3126

Query: 515  GKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
                  F +    SC +G+ILSG   + +CT +G W+
Sbjct: 3127 RIDGTTFSSSVIYSCMEGYILSG-PSVRQCTANGTWS 3162



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 66/251 (26%), Positives = 95/251 (37%), Gaps = 30/251 (11%)

Query: 315  GLQYECTACPSGT---------YKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREG 365
            G Q EC A   G          ++ +G+    S    C +    S P   S   C     
Sbjct: 3104 GRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGP---SVRQCTANGT 3160

Query: 366  YRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGF--DLVGSSIILCLPN 423
            +  +   C ++ C     P NG    +      N +    C PG+  +L GS I  C  N
Sbjct: 3161 WSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVS--YMCQPGYTMELNGSRIRTCTIN 3218

Query: 424  GLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGN 483
            G WSG    CR  TCP   Q  +G +  +  +  +  + +  C  GY L     LTC GN
Sbjct: 3219 GTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYI--CSPGYELSFPAVLTCVGN 3276

Query: 484  SQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAK---FGTICYVSCRQGFILSGVKE 540
              W G  P+C+ + C    +P          GK+  K   + +    SC   FIL G   
Sbjct: 3277 GTWSGEVPQCLPKFCGDPGIPAQ--------GKREGKSFIYQSEVSFSCNFPFILVGSST 3328

Query: 541  MLRCTTSGKWN 551
             + C   G W+
Sbjct: 3329 RI-CQADGTWS 3338



 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 101/450 (22%), Positives = 169/450 (37%), Gaps = 67/450 (14%)

Query: 1785 EPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKA 1844
            E   C  PG P  G   G+ ++    + F CQ G++L+G   I C E+ +W+  IP C  
Sbjct: 660  EKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF 719

Query: 1845 VSCGK----------PAIPEN-----GCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLA 1889
                           P  PE       CI  +    GS++    N  + L    +   + 
Sbjct: 720  PCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFND-FDLESQFDFLAVK 778

Query: 1890 NSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASG 1949
            +     SP +        P ++ +  +IL          +  D   S +G +I   T   
Sbjct: 779  DGDSPESPILGTFTGAEVPSHLTSNSHILR-------LEFQADHSMSGRGFNITYNTFGH 831

Query: 1950 IWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLA-GLDTIEC-LADG 2007
                         C +P    +A   G+NF   ++++  C+EG+    G +TI C L DG
Sbjct: 832  NE-----------CPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDG 880

Query: 2008 K--WSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQG 2065
            K  WS    +C A      P   H S  +   L      YY            L C    
Sbjct: 881  KVMWSGLIPKCGA------PCGGHFSAPSGVILSPGWPGYY---------KDSLNC---- 921

Query: 2066 KWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCME--GFVLNTSAK 2123
            +WV  E +        F      ++Y +LE        +  + S+   +   F+ ++S  
Sbjct: 922  EWVI-EAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNF 980

Query: 2124 IECM----RGGQWNPSPMSIQCIPVR---CGEPPSIMNGYASGSNYSFGAMVAYSCNKGF 2176
            I  +         N   +  + + V    C +P   ++G   G ++S G+ V++SC+ G+
Sbjct: 981  IYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGY 1040

Query: 2177 YIKGEKKSTCEATGQWSSPIPTCHPVSCGE 2206
             +  E+   CE    WS P+PTC  +  G+
Sbjct: 1041 RLSHEEPLLCEKNHWWSHPLPTCDALCGGD 1070



 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 68/245 (27%), Positives = 97/245 (39%), Gaps = 36/245 (14%)

Query: 335  GGISSCIPCPDENHTSPP-GSTSPE-----DCV---CREGYRASGQT------------- 372
            G + SC+P    +  SP  G TS       D V   C  GY   G T             
Sbjct: 2865 GQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHP 2924

Query: 373  ---CELVHCPALKPPENGYFIQNTCNNHFNAACGV--RCHPGFDLVGSSIILCLPNGLWS 427
               C++V+C     P N        + +F     V   C+PG+ L GSS+++C PNG W 
Sbjct: 2925 PPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWD 2984

Query: 428  GSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWD 487
                 C +  C H   P +  +S    +  + +T   +C     L G    TCQ N  W 
Sbjct: 2985 KPLPECIMIDCGHPGVPPNAVLS--GEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWS 3042

Query: 488  GPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYV--SCRQGFILSGVKEMLRCT 545
            G +P C      T   P     +P +  +Q + F T   V  +C  G+IL G +E   C 
Sbjct: 3043 GSQPHCSGDATGTCGDPG----TPGHGSRQESNFRTKSTVRYACDTGYILHGSEER-TCL 3097

Query: 546  TSGKW 550
             +G W
Sbjct: 3098 ANGSW 3102



 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 54/195 (27%), Positives = 77/195 (39%), Gaps = 12/195 (6%)

Query: 361  VCREGYRASGQ--TCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSII 418
            +C++ +  SGQ  +C  V C     P  G    N  N  FN      C+ G+ + G +  
Sbjct: 2856 ICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFN--FNDVVTFSCNIGYLMQGPTKA 2913

Query: 419  LCLPNGLWSGSESYCRVRTC--PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSD 476
             C  N  WS     C+V  C  P +                Y T     C+ GY L GS 
Sbjct: 2914 QCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSS 2973

Query: 477  KLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILS 536
             L CQ N QWD P P C+   C    +P + ++S      +   FG+  + SC     L 
Sbjct: 2974 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLS-----GEKYTFGSTVHYSCTGKRSLL 3028

Query: 537  GVKEMLRCTTSGKWN 551
            G +    C  +G W+
Sbjct: 3029 G-QSSRTCQLNGHWS 3042



 Score = 70.5 bits (171), Expect = 3e-11
 Identities = 184/848 (21%), Positives = 291/848 (34%), Gaps = 158/848 (18%)

Query: 2337 ELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCK-------IVLCTPPPLISF 2389
            E T E+ VVT   K+    +     K  P +  ++ F +           LC  P     
Sbjct: 436  ERTKELAVVTHRVKKAIDFKSRG-FKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPEN 494

Query: 2390 GVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQ----PDGTWSSPLPECVPVECPQPEE 2445
            G  I S     GSTV++SC   + L+G  +  CQ        WS   P C    C    +
Sbjct: 495  GKRIGSD-FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQ 553

Query: 2446 IPNGIIDVQGL----------AYLSTALYTCK------PGFEL-VGNTTTLCGENGHWLG 2488
             P+G                  ++ TA+ T K        F+L +G  T   G+ G  +G
Sbjct: 554  GPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGE-VG 612

Query: 2489 GKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDA 2548
               T          ++L G F   DL     V+ S      L+   ++  +    + V+ 
Sbjct: 613  DPRTV--------LQVLTGSF-VPDL----IVSMSSQMWLHLQTDESVGSV---GFKVNY 656

Query: 2549 PSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPT 2607
                   C  P     G  EG  +S   ++ + C  GF++ G     C+E+  WS++IP 
Sbjct: 657  KEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPI 716

Query: 2608 CM---------PIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVA 2658
            C+         P+   L P    G    L             + + +           +A
Sbjct: 717  CIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLA 776

Query: 2659 KTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCI----- 2713
                ++ ESP      F    + S+  +  + L     L  Q D + +G   +       
Sbjct: 777  VKDGDSPESPIL--GTFTGAEVPSHLTSNSHILR----LEFQADHSMSGRGFNITYNTFG 830

Query: 2714 SIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHI-LAGSDLRLCL---ENRKWSGASPR 2769
              EC  P  P N         +GS++   C+ G I   G++   C+       WSG  P+
Sbjct: 831  HNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPK 890

Query: 2770 CEAISCKKPNPVMNGSIKGSNYT--YLSTL----YYECDPGYVLNGTERRTCQDDKNWDE 2823
            C A  C       +G I    +   Y  +L      E +PG+ +  T  R  Q + N+D 
Sbjct: 891  CGA-PCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFER-FQTELNYDV 948

Query: 2824 DEPICIPVDCSSPPVSANGQVRGDEYTF-QKEIEYTCNEGFLLEGARSRVCLANG---SW 2879
             E    P +  SP + +    +  ++ F      Y     F  + +RS     NG    +
Sbjct: 949  LEVHDGP-NLLSPLLGSYNGTQVPQFLFSSSNFIYLL---FTTDNSRSN----NGFKIHY 1000

Query: 2880 SGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDA 2939
               T +     C  P    +G   G D+     V+F C  GY L     L C+ +  W  
Sbjct: 1001 ESVTVN--TYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSH 1058

Query: 2940 EIPLC-------------------------KPVNCGPPEDLAHGFPNGFSFIHGGHIQYQ 2974
             +P C                           +NC    D+ HG    F+F H  H++  
Sbjct: 1059 PLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNF-HTFHLEDH 1117

Query: 2975 ------------CFPGYKLHGNSSRRCLSNG-----------------SWSG-----SSP 3000
                          P  +L G+     ++ G                 S+ G     S  
Sbjct: 1118 HDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEY 1177

Query: 3001 SCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQ--WSSGFPH 3058
            +  PC     + +YG+  G +F  G      C  G++L G SEI C   G+  WS+  P 
Sbjct: 1178 NLEPCE-DPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPR 1236

Query: 3059 CEHTSCGS 3066
            C    CG+
Sbjct: 1237 CV-AECGA 1243



 Score = 70.1 bits (170), Expect = 4e-11
 Identities = 51/200 (25%), Positives = 82/200 (41%), Gaps = 15/200 (7%)

Query: 372  TCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSES 431
            TC  V CP      NG  ++ T N  +  +    C PG++L   +++ C+ NG WSG   
Sbjct: 3227 TCRAVTCPTPPQISNGR-LEGT-NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVP 3284

Query: 432  YCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEP 491
             C  + C     P  G      +  +Y++    +C+  + L GS    CQ +  W G  P
Sbjct: 3285 QCLPKFCGDPGIPAQG--KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSP 3342

Query: 492  RCVERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQGFILSGVKEMLRCTTSGK 549
             C+E   ++ + P    +  H        F  G++    C++G +L G      C     
Sbjct: 3343 HCIEPTQTSCENPG---VPRHGSQNNTFGFQVGSVVQFHCKKGHLLQG-STTRTCLPDLT 3398

Query: 550  WNVGVQAAV----CKDVEAP 565
            W+ G+Q       CK  E P
Sbjct: 3399 WS-GIQPECIPHSCKQPETP 3417



 Score = 70.1 bits (170), Expect = 4e-11
 Identities = 52/195 (26%), Positives = 81/195 (41%), Gaps = 20/195 (10%)

Query: 406  CHPGFDLVGSSIILCLPNGLWSGSESYCRVRT---CPHLRQPKHGHISCSTREMLYKTTC 462
            C+  F LVGSS  +C  +G WSGS  +C   T   C +   P+HG  + +T      +  
Sbjct: 3317 CNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVV 3375

Query: 463  LVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFG 522
               C +G+ L+GS   TC  +  W G +P C+   C   + P    +     G      G
Sbjct: 3376 QFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANV----VGMDLPSHG 3431

Query: 523  TICYVSCRQGFILSGVKEMLRCTTSGKWNVGV------QAAVCKD------VEAPQINCP 570
                 +C+ GF L+G  E   C +   W   V         + KD        +P+++ P
Sbjct: 3432 YTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTPSPKLSVP 3491

Query: 571  KDIEAKTLEQQDSAN 585
             D+ A+    + S N
Sbjct: 3492 DDVFAQNYIWKGSYN 3506



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 156/783 (19%), Positives = 276/783 (35%), Gaps = 108/783 (13%)

Query: 2680 MVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAV 2739
            ++ + C  G+EL+G   ++CQE+  W+ + P CI       TAP  G +   +   G   
Sbjct: 685  VLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPM-GTVLSPDYPEGYGN 743

Query: 2740 QYSCKPGHIL-AGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNY------- 2791
              +C    I   GS + L   +                 P   + G+  G+         
Sbjct: 744  NLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSN 803

Query: 2792 TYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTF 2851
            +++  L ++ D  + ++G       +    +E         C  P +  N +  GD +  
Sbjct: 804  SHILRLEFQAD--HSMSGRGFNITYNTFGHNE---------CPDPGIPINARRFGDNFQL 852

Query: 2852 QKEIEYTCNEGFL-LEGARSRVC-LANGS--WSGATPDCVPVRCATPPQLANGVTEGLDY 2907
               I   C EGF+  +G  +  C L +G   WSG  P C    C       +GV     +
Sbjct: 853  GSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC-GAPCGGHFSAPSGVILSPGW 911

Query: 2908 -GFMKEVTFHCHEGYILHGAP----KLTC---QSDGNWDAEIPLCKPVNCGPPEDLAHGF 2959
             G+ K+ + +C   +++   P    K+T    Q++ N+D       P    P     +G 
Sbjct: 912  PGYYKD-SLNCE--WVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGT 968

Query: 2960 PNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNG 3019
                      +  Y  F       N+  + +   S + ++ SCL      PV  +G   G
Sbjct: 969  QVPQFLFSSSNFIYLLFTTDNSRSNNGFK-IHYESVTVNTYSCLDP--GIPV--HGRRYG 1023

Query: 3020 TDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFI---- 3075
             DF  G      C  G++L     + CE +  WS   P C+   CG     P+  I    
Sbjct: 1024 HDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCD-ALCGGDVRGPSGTILSPG 1082

Query: 3076 -------SETSSWKENV-----ITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCG 3123
                   S   +W  +V     + ++  + ++      L+ TE G ++QP      L+  
Sbjct: 1083 YPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQP---LARLTGS 1139

Query: 3124 SPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCP- 3182
              P   NA   G         +LR +  +++  +    T  +         +  P + P 
Sbjct: 1140 DLPPTINAGLYG-----NFRAQLRFISDFSISYEGFNITFSE--------YNLEPCEDPG 1186

Query: 3183 LPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDG--TWEPPFSDESCSPVS 3240
            +P+  + I   G +F +   ++ SC+ GY  EG +  +C   G   W  P          
Sbjct: 1187 IPQYGSRI---GFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPR---CVAE 1240

Query: 3241 CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKET--- 3297
            CG   +   G ++   Y                E N E +     Q   G+ I   T   
Sbjct: 1241 CGASATNNEGILLSPNYPL------------NYENNHECIYSIQVQAGKGINISARTFHL 1288

Query: 3298 RCETPLEFLNGK---ADIENRTTGPNV----VYSCNRGYSLEGPSEAHCTENGTWSHPVP 3350
                 L+  +GK     +    TG ++    + S +    LE  S+   T+ G +     
Sbjct: 1289 AQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEG-FQLVYT 1347

Query: 3351 LCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDE--TWTQTS 3408
              + + C  P +      +S++  +    +   C  G+ L G  ++ C   E   W    
Sbjct: 1348 SFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPL 1407

Query: 3409 AKC 3411
              C
Sbjct: 1408 PSC 1410



 Score = 65.5 bits (158), Expect = 9e-10
 Identities = 68/272 (25%), Positives = 106/272 (38%), Gaps = 49/272 (18%)

Query: 3240 SCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRC 3299
            SC  P  P HG   G  ++  ST+ + C+ GY L      +C++N  WS  +  C +  C
Sbjct: 1009 SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC-DALC 1067

Query: 3300 ETPL-------------EFLNGKADIE---NRTTGPNVVYSCNRGYSLEGPSEAHCTENG 3343
               +             EF     +     + T G  V ++ +  +  +       TENG
Sbjct: 1068 GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENG 1127

Query: 3344 TWSHPVPLCKPNPCPVPFVIPENALL-----SEKEFYVDQNVSIKCREGFLLQGHGIITC 3398
            +++ P+     +  P       NA L     ++  F  D ++S    EGF +        
Sbjct: 1128 SFTQPLARLTGSDLPPTI----NAGLYGNFRAQLRFISDFSISY---EGFNI-------- 1172

Query: 3399 NPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLE 3458
                    T ++     C  P   +     G ++  GD +T+SC SGY LEG    +CL 
Sbjct: 1173 --------TFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLG 1224

Query: 3459 NG--TWTSP-PICRAVCRFPCQNG-GICQRPN 3486
             G   W++P P C A C     N  GI   PN
Sbjct: 1225 GGRRVWSAPLPRCVAECGASATNNEGILLSPN 1256



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 75/307 (24%), Positives = 110/307 (35%), Gaps = 43/307 (14%)

Query: 307  CEKGYYGKGLQYECTACPSGTYKPEGSPGGIS---------SCIPCPDENHTSPPGSTSP 357
            C+   +  G Q  C+   +GT    G+PG  S         S +    +      GS   
Sbjct: 3035 CQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGS-EE 3093

Query: 358  EDCVCREGYRASGQTCELVHCPALKPPENG--YFIQNTCNNHFNAACGVRCHPGFDLVGS 415
              C+    +      C+ V C       NG  + I  T    F+++    C  G+ L G 
Sbjct: 3094 RTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTT---FSSSVIYSCMEGYILSGP 3150

Query: 416  SIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA------CDEG 469
            S+  C  NG WSG+   C + +C     P +G        + Y    +V       C  G
Sbjct: 3151 SVRQCTANGTWSGTLPNCTIISCGDPGIPANG--------LRYGDDYVVGQNVSYMCQPG 3202

Query: 470  YRLE--GSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFG---TI 524
            Y +E  GS   TC  N  W G  P C    C T   P  +     N   +   F    +I
Sbjct: 3203 YTMELNGSRIRTCTINGTWSGVMPTCRAVTCPT---PPQI----SNGRLEGTNFDWGFSI 3255

Query: 525  CYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSA 584
             Y+ C  G+ LS    +L C  +G W+  V   + K    P I      E K+   Q   
Sbjct: 3256 SYI-CSPGYELS-FPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEV 3313

Query: 585  NVTWQIP 591
            + +   P
Sbjct: 3314 SFSCNFP 3320



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 31/89 (34%), Positives = 39/89 (43%), Gaps = 4/89 (4%)

Query: 1789 CKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGE----WNHLIPYCKA 1844
            C  PG PENG   G  +++G+ V FSC E Y L G   ITC    E    W+   P CK 
Sbjct: 486  CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 545

Query: 1845 VSCGKPAIPENGCIEELAFTFGSKVTYRC 1873
             +CG      +G      F F      +C
Sbjct: 546  KTCGSNLQGPSGTFTSPNFPFQYDSNAQC 574



 Score = 57.4 bits (137), Expect = 3e-07
 Identities = 56/208 (26%), Positives = 82/208 (39%), Gaps = 27/208 (12%)

Query: 361  VCRE---GYRASGQ---TCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVG 414
            VCR+   GY A       C+ + C   K P NG  +  T +          C+ G+ L  
Sbjct: 2609 VCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGIL--TTDYLVGTRVTYFCNDGYRLSS 2666

Query: 415  SSII--LCLPNGLWSGSESY--CRVRTCPHLRQ--PKHGH---ISCSTREMLYKTTCLVA 465
              +   +C  +G WS       C V TCP +     +HG    ++ S  E  YKT  + +
Sbjct: 2667 KELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYE--YKTKVVFS 2724

Query: 466  CDEGYRLEGSDKLTC--QGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGT 523
            CD GY   G   + C   G   W    P C    C     P     + +  G Q   +G+
Sbjct: 2725 CDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPP----NGNKIGTQ-TSYGS 2779

Query: 524  ICYVSCRQGFILSGVKEMLRCTTSGKWN 551
                +C  GF+L G   +  C +SG W+
Sbjct: 2780 TAIFTCDLGFMLVG-SAVRECLSSGLWS 2806



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 94/421 (22%), Positives = 147/421 (34%), Gaps = 52/421 (12%)

Query: 1905 CSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIEC----TASGIWDRAPPACHL 1960
            C  P    NGK I S  +  ST  +SCD  Y LQG   I C         W    P C +
Sbjct: 486  CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 545

Query: 1961 VFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVS 2020
              CG          T  NF F+      C   + +  ++T + +        ++  L + 
Sbjct: 546  KTCGSNLQGPSGTFTSPNFPFQYDSNAQCV--WVITAVNTNKVIQ----INFEEFDLEIG 599

Query: 2021 CDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQ-GKWVPPEG--QDMPR 2077
             D   I D         +   +   +  D   ++ +SQ+  + Q  + V   G   +   
Sbjct: 600  YDTLTIGDGGEVGDPRTVLQVLTGSFVPD-LIVSMSSQMWLHLQTDESVGSVGFKVNYKE 658

Query: 2078 CIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPS-P 2136
                 C  P +  Y I E      F+   V+ F+C  GF L     I C    QW+ + P
Sbjct: 659  IEKESCGDPGTPLYGIREGDG---FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIP 715

Query: 2137 MSI-QCI-----PVRCGEPPSIMNGYASGSNYSF------GAMVAYSCNKGFYIKGEKKS 2184
            + I  C+     P+     P    GY +  N  +      G+ +  S N  F ++ +   
Sbjct: 716  ICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDF 774

Query: 2185 TCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFV 2244
                 G  S   P     +  E P        H T       + +Q +      G   F 
Sbjct: 775  LAVKDGD-SPESPILGTFTGAEVP-------SHLTSNSHILRLEFQADHSMSGRG---FN 823

Query: 2245 CQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGY-ELVGDSSWT 2303
               N   H+E P   +P+         N    G+NF++GS +   C EG+ +  G  + T
Sbjct: 824  ITYNTFGHNECPDPGIPI---------NARRFGDNFQLGSSISVICEEGFIKTQGTETIT 874

Query: 2304 C 2304
            C
Sbjct: 875  C 875



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 58/255 (22%), Positives = 94/255 (36%), Gaps = 38/255 (14%)

Query: 3241 CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQ----WSGGVAICKE 3296
            C  P  PE+G  +GS ++  ST+ + C+  Y L+G +   CQ   +    WS    +CK 
Sbjct: 486  CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 545

Query: 3297 TRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNP 3356
              C + L+  +G        T PN        +  +  S A C    T  +   + + N 
Sbjct: 546  KTCGSNLQGPSG------TFTSPN--------FPFQYDSNAQCVWVITAVNTNKVIQINF 591

Query: 3357 CPVPFVIPENAL-LSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSA------ 3409
                  I  + L + +     D    ++   G  +    +I     + W           
Sbjct: 592  EEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVP--DLIVSMSSQMWLHLQTDESVGS 649

Query: 3410 --------KCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGT 3461
                    + EK SCG P      I  G  +   D++ + C  G+ L G    VC EN  
Sbjct: 650  VGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ 709

Query: 3462 WTSPPICRAVCRFPC 3476
            W++      +C FPC
Sbjct: 710  WSAN---IPICIFPC 721



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 23/59 (38%), Positives = 30/59 (50%), Gaps = 4/59 (6%)

Query: 1846 SCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANS----SWSHSPPVC 1900
            SCG P +P  G +    F  G K+ Y C  GY L G  + +C+ANS    SW    P+C
Sbjct: 177  SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 43/139 (30%), Positives = 55/139 (39%), Gaps = 17/139 (12%)

Query: 438  CPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQ----GNSQWDGPEPRC 493
            C     P HG+I   T   L  +    ACD G+RL G     C+    G   WD P P C
Sbjct: 2569 CSTPESPPHGYIISQTGGQL-NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2627

Query: 494  VERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQGFILSGVKEMLR--CTTSGK 549
                C    +PK    +P N G     +  GT     C  G+ LS  KE+    C + G 
Sbjct: 2628 QAISCG---IPK----APTNGGILTTDYLVGTRVTYFCNDGYRLSS-KELTTAVCQSDGT 2679

Query: 550  WNVGVQAAVCKDVEAPQIN 568
            W+   +   C  V  P IN
Sbjct: 2680 WSNHNKTPRCVVVTCPSIN 2698



 Score = 48.9 bits (115), Expect = 9e-05
 Identities = 24/61 (39%), Positives = 32/61 (52%), Gaps = 5/61 (8%)

Query: 3415 SCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLEN----GTWTSP-PICR 3469
            SCG P      +  G  +  GD I YSC +GY+L+G  +  C+ N     +W  P PICR
Sbjct: 177  SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 236

Query: 3470 A 3470
            A
Sbjct: 237  A 237



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 54/251 (21%), Positives = 82/251 (32%), Gaps = 59/251 (23%)

Query: 1690 CGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTD----NGSWNGVSPSCLD 1745
            C  P   ENG     DF  GSTV + C+  Y L G   + C        +W+   P C  
Sbjct: 486  CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC-K 544

Query: 1746 VDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIY 1805
            V  C         ++     G++     P        C   I            ++ ++ 
Sbjct: 545  VKTCG--------SNLQGPSGTFTSPNFPFQYDSNAQCVWVI---------TAVNTNKVI 587

Query: 1806 TVGAEVTFSCQEGYQLMGV----------------------TKITCLESGEWNHL----- 1838
             +  E  F  + GY  + +                        I  + S  W HL     
Sbjct: 588  QINFE-EFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDES 646

Query: 1839 -------IPY--CKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLA 1889
                   + Y   +  SCG P  P  G  E   F+    + + C  G+ L G+K   C  
Sbjct: 647  VGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQE 706

Query: 1890 NSSWSHSPPVC 1900
            N+ WS + P+C
Sbjct: 707  NNQWSANIPIC 717



 Score = 45.8 bits (107), Expect = 8e-04
 Identities = 29/104 (27%), Positives = 43/104 (41%), Gaps = 6/104 (5%)

Query: 395  NNHFNAACG----VRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHIS 450
            NN F    G      C  G  L GS+   CLP+  WSG +  C   +C     P H ++ 
Sbjct: 3364 NNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANV- 3422

Query: 451  CSTREMLYKTTCLVACDEGYRLE-GSDKLTCQGNSQWDGPEPRC 493
                   +  T +  C  G+ L  G++   C+ ++ W G  P C
Sbjct: 3423 VGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3466



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 5/80 (6%)

Query: 1789 CKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCL----ESGEWNHLIPYCKA 1844
            C  PG P  G   G  + VG ++ +SC  GY L G  ++TC+     +  W+  +P C+A
Sbjct: 178  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237

Query: 1845 V-SCGKPAIPENGCIEELAF 1863
              +CG      +G I   +F
Sbjct: 238  EDACGGTMRGSSGIISSPSF 257



 Score = 43.9 bits (102), Expect = 0.003
 Identities = 26/90 (28%), Positives = 41/90 (45%), Gaps = 5/90 (5%)

Query: 2891 CATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSD----GNWDAEIPLCKP 2946
            C  P     GV  G  +    ++ + C  GYIL G P+LTC ++     +WD  +P+C+ 
Sbjct: 178  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237

Query: 2947 VN-CGPPEDLAHGFPNGFSFIHGGHIQYQC 2975
             + CG     + G  +  SF +  H    C
Sbjct: 238  EDACGGTMRGSSGIISSPSFPNEYHNNADC 267



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 22/75 (29%), Positives = 33/75 (44%), Gaps = 5/75 (6%)

Query: 2146 CGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEA----TGQWSSPIPTCHP 2201
            CG P     G   G+ +  G  + YSC  G+ + G  + TC A    T  W  P+P C  
Sbjct: 178  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237

Query: 2202 V-SCGEPPKVENGFL 2215
              +CG   +  +G +
Sbjct: 238  EDACGGTMRGSSGII 252



 Score = 42.7 bits (99), Expect = 0.006
 Identities = 23/65 (35%), Positives = 31/65 (47%), Gaps = 4/65 (6%)

Query: 1847 CGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCL----ANSSWSHSPPVCEP 1902
            C  P  PENG      F+ GS V + C++ Y L G K  +C       ++WS   PVC+ 
Sbjct: 486  CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 545

Query: 1903 VKCSS 1907
              C S
Sbjct: 546  KTCGS 550



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 17/59 (28%), Positives = 28/59 (47%)

Query: 1686 ERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCL 1744
            E+ SCG P     G    D F     + ++C  G+ L+G+  + C +N  W+   P C+
Sbjct: 660  EKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICI 718



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 5/63 (7%)

Query: 3415 SCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCL-----ENGTWTSPPICR 3469
            SC  P ++ N    G+ Y+ G  +TY C +GY+L+G+    C+       G   + P C 
Sbjct: 1700 SCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH 1759

Query: 3470 AVC 3472
            A C
Sbjct: 1760 APC 1762



 Score = 41.6 bits (96), Expect = 0.014
 Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 2/54 (3%)

Query: 461  TCLVACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCVERHCSTFQMPKDVIISPH 512
            T   +C  GYRLEG+ ++ C G  +  W  P PRCV    ++    + +++SP+
Sbjct: 1203 TLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPN 1256



 Score = 41.2 bits (95), Expect = 0.019
 Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 3/61 (4%)

Query: 3415 SCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGT--WTSP-PICRAV 3471
            SC  P    + I  G  Y  GD++++ C  GY L+G     C+      W  P PIC A 
Sbjct: 2051 SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQ 2110

Query: 3472 C 3472
            C
Sbjct: 2111 C 2111



 Score = 40.8 bits (94), Expect = 0.024
 Identities = 21/66 (31%), Positives = 29/66 (43%), Gaps = 4/66 (6%)

Query: 3234 ESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQEN----RQWSG 3289
            E     SCG P  P  G + G+++     I Y C  GY L+G+ +  C  N      W  
Sbjct: 171  EELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 230

Query: 3290 GVAICK 3295
             V IC+
Sbjct: 231  PVPICR 236



 Score = 39.3 bits (90), Expect = 0.071
 Identities = 18/47 (38%), Positives = 24/47 (51%), Gaps = 3/47 (6%)

Query: 1647 DLKPGSKVNLFCDPGFQLVGNPVQYCLN--QGQWTQPLPHCERISCG 1691
            D   G  ++  C PG+ L+GN    CL+     W  PLP CE + CG
Sbjct: 2239 DFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-CG 2284



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 24/86 (27%), Positives = 37/86 (43%), Gaps = 5/86 (5%)

Query: 3036 FKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYV 3095
            F L   S+    A G +   +   + +SCG+  + P   +  T     + I YSC +GY+
Sbjct: 151  FSLRLTSDFAVSAHG-FKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYI 209

Query: 3096 IQGSSDLICTEKGV----WSQPYPVC 3117
            + G   L C    V    W  P P+C
Sbjct: 210  LDGHPQLTCIANSVNTASWDFPVPIC 235



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 24/81 (29%), Positives = 33/81 (40%), Gaps = 10/81 (12%)

Query: 2714 SIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN----RKWSGASPR 2769
            S  C  P  P  G L  T   +G  ++YSC  G+IL G     C+ N      W    P 
Sbjct: 175  SSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 234

Query: 2770 CEAISCKKPNPVMNGSIKGSN 2790
            C A           G+++GS+
Sbjct: 235  CRA------EDACGGTMRGSS 249



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 16/46 (34%), Positives = 22/46 (47%)

Query: 466 CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
           C  G+ L G   + CQ N+QW    P C+    S F  P   ++SP
Sbjct: 690 CQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSP 735



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 18/52 (34%), Positives = 24/52 (46%)

Query: 460  TTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
            +T   +CD GYRL   + L C+ N  W  P P C        + P   I+SP
Sbjct: 1030 STVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSP 1081



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 4/99 (4%)

Query: 437  TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGN--SQWDGPEPRCV 494
            +CP  + P  G I    R M+        CD+GY L+G   +TC      +W+ P P C+
Sbjct: 2051 SCPEPQTPSSG-IKIGDRYMVGDVVSF-QCDQGYSLQGHSHITCMPGPVRRWNYPIPICL 2108

Query: 495  ERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGF 533
             +          VI+SP   G  P+       ++   GF
Sbjct: 2109 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGF 2147



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 18/58 (31%), Positives = 27/58 (46%), Gaps = 4/58 (6%)

Query: 2833 CSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLAN----GSWSGATPDC 2886
            C +P V   G + G  +    +I Y+C  G++L+G     C+AN     SW    P C
Sbjct: 178  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 21/57 (36%), Positives = 26/57 (45%), Gaps = 8/57 (14%)

Query: 2501 PKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCL----ETGDWDVDAPSCNA 2553
            PK +L G    T    G  + YSC  G+ L+G   LTC+     T  WD   P C A
Sbjct: 185  PKGVLYG----TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237



 Score = 37.4 bits (85), Expect = 0.27
 Identities = 24/80 (30%), Positives = 37/80 (46%), Gaps = 7/80 (8%)

Query: 438 CPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQ----WDGPEPRC 493
           CP   +P++G    S  +    +T   +CDE Y L+G+  +TCQ  ++    W    P C
Sbjct: 486 CPDPGEPENGKRIGS--DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543

Query: 494 VERHC-STFQMPKDVIISPH 512
             + C S  Q P     SP+
Sbjct: 544 KVKTCGSNLQGPSGTFTSPN 563



 Score = 37.4 bits (85), Expect = 0.27
 Identities = 18/59 (30%), Positives = 28/59 (47%), Gaps = 2/59 (3%)

Query: 363  REGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCL 421
            ++G+    Q  +L  CP  +P  NG+ I N             C PG+ L+G+S + CL
Sbjct: 2209 KQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFT--VGQTISFECFPGYTLIGNSALTCL 2265



 Score = 37.4 bits (85), Expect = 0.27
 Identities = 20/61 (32%), Positives = 26/61 (42%), Gaps = 3/61 (4%)

Query: 3415 SCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLE--NGTWTSP-PICRAV 3471
            SC  P    N    G  +  G  I++ C+ GY L G     CL   +  W  P P C A+
Sbjct: 2223 SCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL 2282

Query: 3472 C 3472
            C
Sbjct: 2283 C 2283



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 22/80 (27%), Positives = 35/80 (43%), Gaps = 10/80 (12%)

Query: 2771 EAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTC----QDDKNWDEDEP 2826
            ++ SC  P     G + G+ +     + Y C  GY+L+G  + TC     +  +WD   P
Sbjct: 174  QSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVP 233

Query: 2827 ICIPVDCSSPPVSANGQVRG 2846
            IC   D      +  G +RG
Sbjct: 234  ICRAED------ACGGTMRG 247



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 16/41 (39%), Positives = 21/41 (51%)

Query: 2264 CGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTC 2304
            CG P     G + G  F+VG K+++ C  GY L G    TC
Sbjct: 178  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTC 218



 Score = 36.2 bits (82), Expect = 0.60
 Identities = 20/65 (30%), Positives = 27/65 (41%), Gaps = 6/65 (9%)

Query: 2556 CDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTC-----EESGWSSSIPTCMP 2610
            C +P     G + G  +  G  I YSC  G+ + GH   TC       + W   +P C  
Sbjct: 178  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237

Query: 2611 ID-CG 2614
             D CG
Sbjct: 238  EDACG 242



 Score = 35.8 bits (81), Expect = 0.78
 Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 4/62 (6%)

Query: 3415 SCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCL--ENGTW--TSPPICRA 3470
            +C  P    N    G   + GD + + C  GY L+G  R  C+  EN  +   SPP+C A
Sbjct: 1527 ACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1586

Query: 3471 VC 3472
             C
Sbjct: 1587 PC 1588



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 4/65 (6%)

Query: 1689 SCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDN----GSWNGVSPSCL 1744
            SCG P     G      F  G  + Y C  GY L G  ++ C  N     SW+   P C 
Sbjct: 177  SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 236

Query: 1745 DVDEC 1749
              D C
Sbjct: 237  AEDAC 241



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 15/40 (37%), Positives = 21/40 (52%), Gaps = 4/40 (10%)

Query: 3318 GPNVVYSCNRGYSLEGPSEAHCTEN----GTWSHPVPLCK 3353
            G  + YSC  GY L+G  +  C  N     +W  PVP+C+
Sbjct: 197  GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 236



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 18/52 (34%), Positives = 27/52 (51%), Gaps = 4/52 (7%)

Query: 464 VACDEGY-RLEGSDKLTC---QGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
           V C+EG+ + +G++ +TC    G   W G  P+C       F  P  VI+SP
Sbjct: 858 VICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSP 909



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 20/59 (33%), Positives = 25/59 (42%), Gaps = 4/59 (6%)

Query: 2948 NCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSN----GSWSGSSPSC 3002
            +CG P     G   G  F  G  I+Y C  GY L G+    C++N     SW    P C
Sbjct: 177  SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 25/79 (31%), Positives = 32/79 (40%), Gaps = 6/79 (7%)

Query: 3007 CSTP-VIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEAD----GQWSSGFPHCE- 3060
            C  P V   G + GT FD G   R  C  G+ L G  ++TC A+      W    P C  
Sbjct: 178  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237

Query: 3061 HTSCGSLPMIPNAFISETS 3079
              +CG      +  IS  S
Sbjct: 238  EDACGGTMRGSSGIISSPS 256



 Score = 34.7 bits (78), Expect = 1.7
 Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%)

Query: 364  EGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVR-CHPGFDLVGSSIILCL 421
            EG++    + EL HC     P+ GY I +    HF  +  +  C+PG+ L GSS++ C+
Sbjct: 1340 EGFQLVYTSFELSHCEDPGIPQFGYKISD--QGHFAGSTIIYGCNPGYTLHGSSLLKCM 1396



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 32/105 (30%), Positives = 41/105 (39%), Gaps = 15/105 (14%)

Query: 2203 SCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQAN----RHWHSESPLM 2258
            SCG P     G L  T   + + ++RY C  GY   G P   C AN      W    P+ 
Sbjct: 177  SCGNPGVPPKGVLYGTRFDVGD-KIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235

Query: 2259 CVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWT 2303
                 CG       G M+G +  + S    F NE Y    D +WT
Sbjct: 236  RAEDACG-------GTMRGSSGIISS--PSFPNE-YHNNADCTWT 270



 Score = 33.5 bits (75), Expect = 3.9
 Identities = 14/44 (31%), Positives = 21/44 (47%)

Query: 1963 CGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLAD 2006
            CG P      V+ G  F   + + Y+C  GY L G   + C+A+
Sbjct: 178  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIAN 221



 Score = 33.1 bits (74), Expect = 5.1
 Identities = 21/67 (31%), Positives = 28/67 (41%), Gaps = 5/67 (7%)

Query: 3355 NPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC----NPDETWTQTSAK 3410
            N CP P   PEN      +F +   V   C E ++LQG   ITC         W+     
Sbjct: 484  NLCPDPGE-PENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 542

Query: 3411 CEKISCG 3417
            C+  +CG
Sbjct: 543  CKVKTCG 549



 Score = 32.7 bits (73), Expect = 6.6
 Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 2/37 (5%)

Query: 460  TTCLVACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCV 494
            +T +  C+ GY L GS  L C    +  WD P P C+
Sbjct: 1375 STIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCI 1411



 Score = 32.3 bits (72), Expect = 8.6
 Identities = 26/104 (25%), Positives = 35/104 (33%), Gaps = 5/104 (4%)

Query: 1929 YSCDTGYSLQGPSIIECTASGI----WDRAPPACHLV-FCGEPPAIKDAVITGNNFTFRN 1983
            YSC TGY L G   + C A+ +    WD   P C     CG        +I+  +F    
Sbjct: 202  YSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEY 261

Query: 1984 TVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIV 2027
                 C         DTI  +            L +   EPP +
Sbjct: 262  HNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTI 305



 Score = 32.3 bits (72), Expect = 8.6
 Identities = 21/53 (39%), Positives = 26/53 (49%), Gaps = 6/53 (11%)

Query: 465 ACDEGYRLEGSDKLTCQGNS----QWDGPEPRC-VERHC-STFQMPKDVIISP 511
           +C  GY L+G  +LTC  NS     WD P P C  E  C  T +    +I SP
Sbjct: 203 SCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSP 255


>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
          Length = 3565

 Score =  505 bits (1300), Expect = e-142
 Identities = 345/1145 (30%), Positives = 490/1145 (42%), Gaps = 124/1145 (10%)

Query: 2322 KCPEPPLL-ENQLVLKELTTEVG-VVTFSCKEGHVLQGPSVLKC-LPSQ-QWNDSFPVCK 2377
            KC  PP + + +++ ++   E+G  V + C  G+ L G  +L C L SQ Q+  S P C+
Sbjct: 2258 KCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCE 2317

Query: 2378 IVLCTPPPLISFGVPIPSSALHFGST---VKYSCVGGFFLRGNSTTLCQPDGTWSSPLPE 2434
                            P++ +  GS+   +     G +F   NS T      +WS  +  
Sbjct: 2318 -------------AQCPANEVRTGSSGVILSPGYPGNYF---NSQTC-----SWSIKVEP 2356

Query: 2435 ----CVPVECPQPE------EIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENG 2484
                 + V+  Q E      E+ +G      L  + +  +T +  F    N   L     
Sbjct: 2357 NYNITIFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTD 2416

Query: 2485 HWLGGK--------PTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSAL 2536
            H    K        P C     LK   ILN     T    G  V Y C  G+R+ G S  
Sbjct: 2417 HATSKKGFKIRYAAPYCSLTHPLKNGGILNR----TAGAVGSKVHYFCKPGYRMVGHSNA 2472

Query: 2537 TC----LETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHA 2592
            TC    L    WD   P C A+ C  P+   NG   G +++  + ++Y C  GF++    
Sbjct: 2473 TCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTGNEFTLDSKVVYECHEGFKLESSQ 2532

Query: 2593 MQT--CEESG-WSSS--IPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVT 2647
              T  C+E G WS+    PTC P+ C   P I+                         ++
Sbjct: 2533 QATAVCQEDGLWSNKGKPPTCKPVAC---PSIE-----------------------AQLS 2566

Query: 2648 PHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWN- 2706
             H  + L                  S   YG  V  +C+PGY L G  +L CQ +GTWN 
Sbjct: 2567 EHVIWRL---------------VSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNI 2611

Query: 2707 -GSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSG 2765
                PSC  I C   + P NG    T T  G+   ++C  G+ L GS +R CL N  WSG
Sbjct: 2612 GDERPSCRVISCGSLSFPPNGNKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSG 2671

Query: 2766 ASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDE 2825
            +  RC A  C  P+P++NG I G  ++Y  T+ Y+C+PG+ L GT  R C  D  W    
Sbjct: 2672 SETRCLAGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQT 2731

Query: 2826 PICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPD 2885
            P+C+P+ C  P   A+G   G E+     + +TCN G+LL+G     C +NG WS   P 
Sbjct: 2732 PVCVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPT 2791

Query: 2886 CVPVRCATPPQLANGVTEG-------LDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWD 2938
            C  V C+ P  + N +  G        +YG    + +HC +G+ L G+  LTC ++G WD
Sbjct: 2792 CRVVNCSDPGFVENAIRHGQQNFPESFEYGM--SILYHCKKGFYLLGSSALTCMANGLWD 2849

Query: 2939 AEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGS 2998
              +P C  ++CG P   A+    G  F +G  + Y C     L GN +R C  +  WSG+
Sbjct: 2850 RSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGA 2909

Query: 2999 SPSCL---PCRCSTP-VIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSS 3054
             P C    P  C  P    +G+  G DF      R  C  G +L G  E TC  +G WS 
Sbjct: 2910 LPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSG 2969

Query: 3055 GFPHCEHTSCGSLPMIPNAFI-SETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQP 3113
              P CE  SCG+     N  I S       + + Y+C  GY   G     CT  G W+  
Sbjct: 2970 LQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGT 3029

Query: 3114 YPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTD-TFTCQKDGRWFPE 3172
             P C  +SCG P ++AN +  G   T+   V  +C  GY M+  T  T  C KDGRW P 
Sbjct: 3030 APDCTIISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPS 3089

Query: 3173 RISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFS 3232
            +  C    CP P  + +  V G DF     +S SC +GY      I  C+  G W+    
Sbjct: 3090 KPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEI- 3148

Query: 3233 DESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVA 3292
               C PV CG P  P  G + G  +T++S + +QC+  + L G+  RVCQ +  WSG   
Sbjct: 3149 -PQCLPVFCGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQP 3207

Query: 3293 ICKETRCETPLEFLNGKADIENRT----TGPNVVYSCNRGYSLEGPSEAHCTENGTWSHP 3348
             C +    T  +       I+N +     G  V + C +GY ++G +   C  N TWS  
Sbjct: 3208 TCIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGI 3267

Query: 3349 VPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHG-IITCNPDETWTQT 3407
               C P+ C  P       + +         +   C  GF L G     TC  D  WT  
Sbjct: 3268 QTECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGK 3327

Query: 3408 SAKCE 3412
            S  C+
Sbjct: 3328 SPVCK 3332



 Score =  496 bits (1276), Expect = e-139
 Identities = 445/1685 (26%), Positives = 659/1685 (39%), Gaps = 206/1685 (12%)

Query: 1642 RTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQ----GQWTQPLPHC------------ 1685
            R    +   GS V   C+PG+ L G+   +C +      QW   +P C            
Sbjct: 1752 RRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVVPCSGNFTQRR 1811

Query: 1686 -ERISCGVPPPLENGFH----------SADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNG 1734
               +S G P P  N  +          S       S  T Q  +   +     +     G
Sbjct: 1812 GTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIHDGGDVTAPRLG 1871

Query: 1735 SWNGVS-PSCLDVDECAV----GSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKC 1789
            S++G + P+ L+     +     SD S  A+  +++   +                   C
Sbjct: 1872 SFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAA---------------C 1916

Query: 1790 KAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESG--EWNHLIPYCKAVSC 1847
            + P  P N    G+ Y V   ++F C+ GY L G + I+C+      WN+  P C A +C
Sbjct: 1917 QEPALPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIA-TC 1975

Query: 1848 GKPAIPENGCIEELAFTFGSKVTYRCNKGYTLA-GDKESSCLANSSWSHSPPVCEPVKCS 1906
            G       G I    F         C    +L  G        N S   +    E     
Sbjct: 1976 GGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLE----- 2030

Query: 1907 SPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDR-----APPACHLV 1961
                I NG Y  S +    + +       S    ++I   +    +R     A  A  L 
Sbjct: 2031 ----IQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQ 2086

Query: 1962 FCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECL--ADGKWSRSDQQCLA- 2018
             C +PP  ++  +  ++++   +V++ C  GY L G   + C    +  W+    +C A 
Sbjct: 2087 NCPDPPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAP 2146

Query: 2019 ----VSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQ-----GKWVP 2069
                V+     I     P+    L   I       G+ +  N  LL           W  
Sbjct: 2147 CGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAVWDG 2206

Query: 2070 PEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRG 2129
            P+ Q+ P+            +YS    V     +  S   F     FVLN  A       
Sbjct: 2207 PD-QNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGF-----FVLNFHA------- 2253

Query: 2130 GQWNPSPMSIQCIPVRCGEPPSIMNG--YASGSNYSFGAMVAYSCNKGFYIKGEKKSTCE 2187
                     ++    +C  PP++          ++  G  V Y C+ G+ + G    TC+
Sbjct: 2254 -------FQLK----KCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCK 2302

Query: 2188 ATGQ--WSSPIPTCHP-VSCGEPPKVENGFLEHT--TGRIFESEV---RYQCNPGYKSVG 2239
             + Q  +   +PTC       E     +G +      G  F S+      +  P Y ++ 
Sbjct: 2303 LSSQLQFEGSLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNY-NIT 2361

Query: 2240 SPVFVCQANRHWHS---------ESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFC 2290
              V   Q+ + + +         +SPL+ V         +     +  NF   S      
Sbjct: 2362 IFVDTFQSEKQFDALEVFDGSSGQSPLLVV---------LSGNHTEQSNFTSRS------ 2406

Query: 2291 NEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGV-VTFSC 2349
            N+ Y L   +     K G   + + P C       P  L+N  +L      VG  V + C
Sbjct: 2407 NQLY-LRWSTDHATSKKGFKIRYAAPYC---SLTHP--LKNGGILNRTAGAVGSKVHYFC 2460

Query: 2350 KEGHVLQGPSVLKC----LPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVK 2405
            K G+ + G S   C    L   QW+   P+C+ V C  P     G     +     S V 
Sbjct: 2461 KPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNG-SFTGNEFTLDSKVV 2519

Query: 2406 YSCVGGFFLRGN--STTLCQPDGTWSSP--LPECVPVECPQ-----PEEIPNGIIDVQGL 2456
            Y C  GF L  +  +T +CQ DG WS+    P C PV CP       E +   ++     
Sbjct: 2520 YECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLN 2579

Query: 2457 AYLSTALYTCKPGFELVGNTTTLCGENGHWLGG--KPTCKAIECLKPKEILNGKFSYTDL 2514
             Y +  L +C PG+ L G     C  NG W  G  +P+C+ I C       NG    T  
Sbjct: 2580 EYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTLT 2639

Query: 2515 HYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSY 2574
             YG T  ++CN G+ L G     CL  G W      C A HC SP PI NG + G  +SY
Sbjct: 2640 VYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNGHISGDGFSY 2699

Query: 2575 GAIIIYSCFPGFQVAGHAMQTC-EESGWSSSIPTCMPIDCGLPPH----------IDFGD 2623
               ++Y C PGF++ G +++ C ++  WS   P C+PI CG P +           +  D
Sbjct: 2700 RDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNLND 2759

Query: 2624 CTKLKDDQGYFEQ--------EDDMMEVPYVT------PHPPYHLGAVAKTWENTKESPA 2669
                  + GY  Q         +     P  T        P +   A+    +N  ES  
Sbjct: 2760 VVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPES-- 2817

Query: 2670 THSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLR 2729
                 F YG  + Y C  G+ LLG+  L C  +G W+ S P C++I C  P  P N  L 
Sbjct: 2818 -----FEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLT 2872

Query: 2730 FTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAIS---CKKPNPVMNGSI 2786
                + G+ V YSC+    L G+D R+C E+  WSGA P C   +   C  P    +GS 
Sbjct: 2873 GELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSR 2932

Query: 2787 KGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQ-VR 2845
             G ++   S L + C+ G+ L G+  RTC  + +W   +P+C  V C +P    NG  V 
Sbjct: 2933 LGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVS 2992

Query: 2846 GDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGL 2905
             D   F   + Y C EG+   G  +R C ANG+W+G  PDC  + C  P  LANG+  G 
Sbjct: 2993 SDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANGIQFGT 3052

Query: 2906 DYGFMKEVTFHCHEGYILHGAPKLT--CQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGF 2963
            D+ F K V++ C+ GY++      T  C  DG W+   P+CK V C  P  + +G   G 
Sbjct: 3053 DFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGS 3112

Query: 2964 SFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVI-EYGTVNGTDF 3022
             F  G  I Y C  GY+L  ++   C   G W G  P CLP  C  P I   G ++G  F
Sbjct: 3113 DFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLSGKSF 3172

Query: 3023 DCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHC---EHTSCGSLPMIPNAFISETS 3079
                    QC   F L+G S   C+ADG WS   P C    H +C   P  P+  I  +S
Sbjct: 3173 TYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPD-PGTPHFGIQNSS 3231

Query: 3080 SWKE--NVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANA-VATGE 3136
               E  + + + CR GY IQGS+   C     WS     C P +C  P + A+A V   +
Sbjct: 3232 RGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAID 3291

Query: 3137 AHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKC-PLPENITHILVHGD 3195
              T+   +   C  G+ +   ++  TC+ D +W  +   C  K    + E +T   V  D
Sbjct: 3292 LPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKSKGVREVNETVTKTPVPSD 3351

Query: 3196 DFSVN 3200
             F VN
Sbjct: 3352 VFFVN 3356



 Score =  486 bits (1251), Expect = e-136
 Identities = 484/1940 (24%), Positives = 729/1940 (37%), Gaps = 324/1940 (16%)

Query: 1687 RISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDV 1746
            R +C  P  + NG     DF  GST+TYQC++GY +L  S +                  
Sbjct: 1562 REACFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSI------------------ 1603

Query: 1747 DECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEI-- 1804
              C +G+D     S   V  S    C   YTG       P       N  + +++G+I  
Sbjct: 1604 -TCVIGADGKP--SWDQVLPSCNAPCGGQYTGSEGVVLSP-------NYPHNYTAGQICL 1653

Query: 1805 --YTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELA 1862
               TV  E     Q  Y    +  +  L  G       + +A      +   +G  E L 
Sbjct: 1654 YSITVPKEFVVFGQFAYFQTALNDLAELFDGT------HAQARLLSSLSGSHSG--ETLP 1705

Query: 1863 FTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLT 1922
                +++  R       +    +S         + P     +CSS      G+ I S  +
Sbjct: 1706 LATSNQILLR------FSAKSGASARGFHFVYQAVPRTSDTQCSSVPEPRYGRRIGSEFS 1759

Query: 1923 YLSTASYSCDTGYSLQGPSIIEC----TASGIWDRAPPACHLVFCGEPPAIKDAVIT--- 1975
              S   + C+ GY LQG + + C     A   W+   P+C +   G     +  +++   
Sbjct: 1760 AGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVVPCSGNFTQRRGTILSPGY 1819

Query: 1976 ----GNNFTFRNTVTYTCKEGYTLAGL--------DTIECLADGKWSRSDQQCLAVSCDE 2023
                GNN      +  T   G  +  +        D++E + DG    + +         
Sbjct: 1820 PEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLE-IHDGGDVTAPRLGSFSGTTV 1878

Query: 2024 PPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFC 2083
            P +++  S +       DI+    + G+ L   +  L                      C
Sbjct: 1879 PALLNSTSNQLYLHFQSDISV--AAAGFHLEYKTVGLAA--------------------C 1916

Query: 2084 EKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGG--QWN-PSPMSIQ 2140
            ++P   S SI       ++    V+SF+C  G+ L   + I CM G   +WN PSP+ I 
Sbjct: 1917 QEPALPSNSIKIG---DRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCI- 1972

Query: 2141 CIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPT-C 2199
                 CG   S + G      +                 G   +  + T + S PI    
Sbjct: 1973 ---ATCGGTLSTLGGVILSPGFP----------------GSYPNNLDCTWRISLPIGYGA 2013

Query: 2200 HPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANR----HWHSES 2255
            H        +  + FLE   G    S +  Q    +     P  +         H++S+ 
Sbjct: 2014 HIQFLNFSTEANHDFLEIQNGPYHTSPMIGQ----FSGTDLPAALLSTTHETLIHFYSDH 2069

Query: 2256 P---------LMCVPL-DCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQ 2305
                           L +C  PPP QNG+M   ++ VG  V F C  GY L+G    TCQ
Sbjct: 2070 SQNRQGFKLAYQAYELQNCPDPPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQ 2129

Query: 2306 K--SGKWNKKSNPKC----------------MPAKCPEPPLLENQLVLKELTTEVGV-VT 2346
               +  WN    P+C                 P    E P+L++ + L  +    GV + 
Sbjct: 2130 HGINRNWNYPF-PRCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYIN 2188

Query: 2347 FSCKEGH-------VLQGPS------------------------VLKCLPSQQWNDSFPV 2375
            F+  +         V  GP                         VL    S   N  F V
Sbjct: 2189 FTLLQTEAVNDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFV 2248

Query: 2376 C-----KIVLCTPPPLISFGVPIPSSA-LHFGSTVKYSCVGGFFLRGNSTTLCQPDGT-- 2427
                  ++  C PPP +     +        G  VKY C  G+ L G     C+      
Sbjct: 2249 LNFHAFQLKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQ 2308

Query: 2428 WSSPLPECVPVECPQPEEIP--NGIIDVQGLAYLSTALYTC------KPGFELVGNTTTL 2479
            +   LP C   +CP  E     +G+I   G         TC      +P + +     T 
Sbjct: 2309 FEGSLPTC-EAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTF 2367

Query: 2480 CGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCL 2539
              E           K  + L   E+ +G    + L     V  S N   +    S    L
Sbjct: 2368 QSE-----------KQFDAL---EVFDGSSGQSPL----LVVLSGNHTEQSNFTSRSNQL 2409

Query: 2540 ETGDWDVDAPSCN--------AIHCDSPQPIENG-FVEGADYSYGAIIIYSCFPGFQVAG 2590
                W  D  +          A +C    P++NG  +     + G+ + Y C PG+++ G
Sbjct: 2410 YLR-WSTDHATSKKGFKIRYAAPYCSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVG 2468

Query: 2591 HAMQTCEESG-----WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPY 2645
            H+  TC  +      W S  P C  + CG+P                             
Sbjct: 2469 HSNATCRRNPLGMYQWDSLTPLCQAVSCGIP----------------------------- 2499

Query: 2646 VTPHPPYHLGAVAKTWENTKESPATHS---SNFLYGTMVSYTCNPGYELLGNP--VLICQ 2700
                                ESP   S   + F   + V Y C+ G++L  +     +CQ
Sbjct: 2500 --------------------ESPGNGSFTGNEFTLDSKVVYECHEGFKLESSQQATAVCQ 2539

Query: 2701 EDGTWN--GSAPSCISIECDLPTAP--ENGFLRFTETSM---GSAVQYSCKPGHILAGSD 2753
            EDG W+  G  P+C  + C    A   E+   R    S+   G+ V  SC PG+ L G  
Sbjct: 2540 EDGLWSNKGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWR 2599

Query: 2754 LRLCLENRKWS--GASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTE 2811
            L  C  N  W+     P C  ISC   +   NG+  G+   Y +T  + C+ GY L G+ 
Sbjct: 2600 LLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTLTVYGATAIFTCNTGYTLVGSH 2659

Query: 2812 RRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSR 2871
             R C  +  W   E  C+   C SP    NG + GD ++++  + Y CN GF L G   R
Sbjct: 2660 VRECLANGLWSGSETRCLAGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVR 2719

Query: 2872 VCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTC 2931
            +CL +  WSG TP CVP+ C  P   A+G T G ++     V F C+ GY+L G  +  C
Sbjct: 2720 ICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQC 2779

Query: 2932 QSDGNWDAEIPLCKPVNCGPP----EDLAHG---FPNGFSFIHGGHIQYQCFPGYKLHGN 2984
            +S+G W + +P C+ VNC  P      + HG   FP  F +  G  I Y C  G+ L G+
Sbjct: 2780 RSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEY--GMSILYHCKKGFYLLGS 2837

Query: 2985 SSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTV-NGTDFDCGKAARIQCFKGFKLLGLSE 3043
            S+  C++NG W  S P CL   C  P +    V  G  F  G      C     L+G   
Sbjct: 2838 SALTCMANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDT 2897

Query: 3044 ITCEADGQWSSGFPHCEHTS---CGSLPMIPNAFISETSSWK-ENVITYSCRSGYVIQGS 3099
              C+ D  WS   PHC   +   CG  P  P         +K ++++ +SC  G+ ++GS
Sbjct: 2898 RVCQEDSHWSGALPHCTGNNPGFCGD-PGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGS 2956

Query: 3100 SDLICTEKGVWSQPYPVCEPLSCGSPPSVANA-VATGEAHTYESEVKLRCLEGYTMDTDT 3158
             +  C   G WS   PVCE +SCG+P +  N  + + +   + S V   C EGY   +  
Sbjct: 2957 PERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKT-SGL 3015

Query: 3159 DTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNI 3218
             T  C  +G W      C+   C  P  + + +  G DF+ N+ VS  C  GY  E V  
Sbjct: 3016 MTRHCTANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTS 3075

Query: 3219 SV--CQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGN 3276
            +   C  DG W P  S   C  V C +P   ++G V GS + + S+I Y C  GY+L  +
Sbjct: 3076 ATIRCTKDGRWNP--SKPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHS 3133

Query: 3277 RERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSE 3336
                C+    W G +  C    C  P     G+   ++ T    V + C   + L G S 
Sbjct: 3134 AILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSR 3193

Query: 3337 AHCTENGTWSHPVPLC---KPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGH 3393
              C  +GTWS   P C     N CP P         S + + V   V  +CR+G+ +QG 
Sbjct: 3194 RVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGS 3253

Query: 3394 GIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHY-QYGDMITYSCYSGYMLE-GF 3451
               TC  + TW+    +C   +C  P    +A  R +    +G  + Y+C+ G+ L  G 
Sbjct: 3254 TTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGS 3313

Query: 3452 LRSVCLENGTWT-SPPICRA 3470
                C  +  WT   P+C++
Sbjct: 3314 EHRTCKADMKWTGKSPVCKS 3333



 Score =  459 bits (1182), Expect = e-128
 Identities = 323/1140 (28%), Positives = 471/1140 (41%), Gaps = 137/1140 (12%)

Query: 2227 VRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKV 2286
            V+YQC+PGY  VG+ +  C+ +     E  L      C                  GS  
Sbjct: 2283 VKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEAQC-----------PANEVRTGSS- 2330

Query: 2287 QFFCNEGYELVGDSSWTCQKSGKWNKKSNP--------------------KCMPAKCPEP 2326
                + GY     +S TC     W+ K  P                    +       + 
Sbjct: 2331 GVILSPGYPGNYFNSQTCS----WSIKVEPNYNITIFVDTFQSEKQFDALEVFDGSSGQS 2386

Query: 2327 PLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPL 2386
            PLL   +VL    TE    T    + ++             +   + P C +      PL
Sbjct: 2387 PLL---VVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYCSLT----HPL 2439

Query: 2387 ISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQ--PDGT--WSSPLPECVPVECPQ 2442
             + G+ +  +A   GS V Y C  G+ + G+S   C+  P G   W S  P C  V C  
Sbjct: 2440 KNGGI-LNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGI 2498

Query: 2443 PEEIPNGIIDVQGLAYLSTALYTCKPGFELVGN--TTTLCGENGHWL--GGKPTCKAIEC 2498
            PE   NG          S  +Y C  GF+L  +   T +C E+G W   G  PTCK + C
Sbjct: 2499 PESPGNGSFTGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVAC 2558

Query: 2499 LKPKEILNGKFSYTDL-----HYGQTVTYSCNRGFRLEGPSALTCLETGDWDV--DAPSC 2551
               +  L+    +  +      YG  V  SC+ G+ LEG   L C   G W++  + PSC
Sbjct: 2559 PSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSC 2618

Query: 2552 NAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPTCMP 2610
              I C S     NG   G    YGA  I++C  G+ + G  ++ C  +G WS S   C+ 
Sbjct: 2619 RVISCGSLSFPPNGNKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLA 2678

Query: 2611 IDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPAT 2670
              CG P                           P V  H                     
Sbjct: 2679 GHCGSPD--------------------------PIVNGH--------------------I 2692

Query: 2671 HSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRF 2730
                F Y   V Y CNPG+ L+G  V IC +D  W+G  P C+ I C  P  P +GF   
Sbjct: 2693 SGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNG 2752

Query: 2731 TETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKG-- 2788
            +E ++   V ++C  G++L G     C  N +WS   P C  ++C  P  V N    G  
Sbjct: 2753 SEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQ 2812

Query: 2789 ---SNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVR 2845
                ++ Y  ++ Y C  G+ L G+   TC  +  WD   P C+ + C  P V AN  + 
Sbjct: 2813 NFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLT 2872

Query: 2846 GDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCV---PVRCATPPQLANGVT 2902
            G+ +T+   + Y+C     L G  +RVC  +  WSGA P C    P  C  P   A+G  
Sbjct: 2873 GELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSR 2932

Query: 2903 EGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHG-FPN 2961
             G D+     + F C  G+ L G+P+ TC  +G+W    P+C+ V+CG P    +G   +
Sbjct: 2933 LGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVS 2992

Query: 2962 GFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTP-VIEYGTVNGT 3020
                +    + Y C+ GYK  G  +R C +NG+W+G++P C    C  P  +  G   GT
Sbjct: 2993 SDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANGIQFGT 3052

Query: 3021 DFDCGKAARIQCFKGFKLLGLSEIT--CEADGQWSSGFPHCEHTSCGSLPMIPNAFISET 3078
            DF   K    QC  G+ +  ++  T  C  DG+W+   P C+   C   P + N  +  +
Sbjct: 3053 DFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGS 3112

Query: 3079 SSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAH 3138
                 + I+YSC  GY +  S+ L C  +GVW    P C P+ CG P   A    +G++ 
Sbjct: 3113 DFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLSGKSF 3172

Query: 3139 TYESEVKLRCLEGYTMDTDTDTFTCQKDGRWF---PERISCSPKKCPLPENITHILVHGD 3195
            TY+SEV  +C   + +   +    CQ DG W    P  I  +   CP P    H  +   
Sbjct: 3173 TYKSEVFFQCKSPFIL-VGSSRRVCQADGTWSGIQPTCIDPAHNTCPDP-GTPHFGIQNS 3230

Query: 3196 D--FSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVV 3253
               + V   V   C +GY  +G     C  + TW        C P +C +PE+P H  V 
Sbjct: 3231 SRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSG--IQTECIPHACRQPETPAHADVR 3288

Query: 3254 GSKY-TFESTIIYQCEPGYELEGNRE-RVCQENRQWSGGVAICK--------ETRCETPL 3303
                 TF  T++Y C PG+ L G  E R C+ + +W+G   +CK        ET  +TP+
Sbjct: 3289 AIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKSKGVREVNETVTKTPV 3348



 Score =  454 bits (1169), Expect = e-127
 Identities = 467/1937 (24%), Positives = 712/1937 (36%), Gaps = 251/1937 (12%)

Query: 1689 SCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSCLD 1745
            +C  P   +NG    D   AG TVT+QC+ GY L G +++ C    +   W    P+C+ 
Sbjct: 1391 TCNDPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCI- 1449

Query: 1746 VDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPG---------NPE 1796
                A G + +  A      G  +    P     GK C   +K              N E
Sbjct: 1450 ---AACGGNLTGPA------GVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNME 1500

Query: 1797 NGHSSGEIYT--------VGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYC------ 1842
              +    IY         +G+       E  +  G +      S     L  +       
Sbjct: 1501 PSYDFLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEK 1560

Query: 1843 KAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANS----SWSHSPP 1898
               +C  P    NG      F  GS +TY+C+ GY +      +C+  +    SW    P
Sbjct: 1561 PREACFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLP 1620

Query: 1899 VCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASG--------- 1949
             C    C      + G  +     +  TA   C   YS+  P   E    G         
Sbjct: 1621 SCN-APCGGQYTGSEGVVLSPNYPHNYTAGQICL--YSITVPK--EFVVFGQFAYFQTAL 1675

Query: 1950 -----IWDRAPPACHLV--FCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIE 2002
                 ++D       L+    G        + T N    R    ++ K G +  G   + 
Sbjct: 1676 NDLAELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLR----FSAKSGASARGFHFVY 1731

Query: 2003 CLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLC- 2061
                     SD QC +V   EP        E +    G I  + C+ GY L  ++ L C 
Sbjct: 1732 QAVP---RTSDTQCSSVP--EPRYGRRIGSEFSA---GSIVRFECNPGYLLQGSTALHCQ 1783

Query: 2062 ---NAQGKWVPPEGQDMPRCIAHFCEKP--------PSVSYSILESVSKAKFAAGSVVSF 2110
               NA  +W       +  C  +F ++         P    + L  + K     GS +  
Sbjct: 1784 SVPNALAQWNDTIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQI 1843

Query: 2111 KCMEGFVLNTSAKIECMRGGQWN-PSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVA 2169
            + +          +E   GG    P   S     V     P+++N  ++     F + ++
Sbjct: 1844 QVISFATEQNWDSLEIHDGGDVTAPRLGSFSGTTV-----PALLNSTSNQLYLHFQSDIS 1898

Query: 2170 YSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRY 2229
             +   GF+++ +                T    +C EP    N  ++     +    + +
Sbjct: 1899 VAA-AGFHLEYK----------------TVGLAACQEPALPSNS-IKIGDRYMVNDVLSF 1940

Query: 2230 QCNPGYKSVGSPVFVCQAN--RHWHSESPLMCVPLDCGKPPPIQNGFMKGENFE------ 2281
            QC PGY   G     C     R W+  SPL C+   CG       G +    F       
Sbjct: 1941 QCEPGYTLQGRSHISCMPGTVRRWNYPSPL-CIAT-CGGTLSTLGGVILSPGFPGSYPNN 1998

Query: 2282 ------------VGSKVQF--FCNEG----YELVGDSSWTCQKSGKWNKKSNPKCMPAKC 2323
                         G+ +QF  F  E      E+      T    G+++    P  + +  
Sbjct: 1999 LDCTWRISLPIGYGAHIQFLNFSTEANHDFLEIQNGPYHTSPMIGQFSGTDLPAALLS-- 2056

Query: 2324 PEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTP 2383
                           TT   ++ F        QG  +           ++   ++  C  
Sbjct: 2057 ---------------TTHETLIHFYSDHSQNRQGFKL-----------AYQAYELQNCPD 2090

Query: 2384 PPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQP--DGTWSSPLPECVPVECP 2441
            PP    G  I +S    G +V + C  G+ L G+    CQ   +  W+ P P C    C 
Sbjct: 2091 PPPFQNGYMI-NSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRC-DAPCG 2148

Query: 2442 QPEEIPNGIIDVQGLAYLSTALYTC------KPGFELVGNTTTLCGENGH-----WLGGK 2490
                  NG I   G       L  C       PG  +  N T L  E  +     W G  
Sbjct: 2149 YNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAVWDGPD 2208

Query: 2491 PTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPS 2550
                 +        L   +S T+    +  +   N GF +    A    +          
Sbjct: 2209 QNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQLKK---------- 2258

Query: 2551 CNAIHCDSPQPIENG--FVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG---WSSSI 2605
                 C  P  +       E  D+  G  + Y C PG+ + G  + TC+ S    +  S+
Sbjct: 2259 -----CQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSL 2313

Query: 2606 PTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPY-VTPHPPYHLGAVAKTWENT 2664
            PTC   +   P +      + +    GY     +     + +   P Y++     T+++ 
Sbjct: 2314 PTC---EAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSE 2370

Query: 2665 KESPATH-------SSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIE- 2716
            K+  A          S  L     ++T    +    N + +     T + ++     I  
Sbjct: 2371 KQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYL--RWSTDHATSKKGFKIRY 2428

Query: 2717 ----CDLPTAPENG-FLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENR----KWSGAS 2767
                C L    +NG  L  T  ++GS V Y CKPG+ + G     C  N     +W   +
Sbjct: 2429 AAPYCSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLT 2488

Query: 2768 PRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRT--CQDDKNWDED- 2824
            P C+A+SC  P    NGS  G+ +T  S + YEC  G+ L  +++ T  CQ+D  W    
Sbjct: 2489 PLCQAVSCGIPESPGNGSFTGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKG 2548

Query: 2825 -EPICIPVDCSSPPVSANGQV-----RGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGS 2878
              P C PV C S     +  V      G    +  ++  +C+ G+ LEG R   C ANG+
Sbjct: 2549 KPPTCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGT 2608

Query: 2879 WS--GATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGN 2936
            W+     P C  + C +     NG   G    +     F C+ GY L G+    C ++G 
Sbjct: 2609 WNIGDERPSCRVISCGSLSFPPNGNKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGL 2668

Query: 2937 WDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWS 2996
            W      C   +CG P+ + +G  +G  F +   + YQC PG++L G S R CL +  WS
Sbjct: 2669 WSGSETRCLAGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWS 2728

Query: 2997 GSSPSCLPCRCSTPVIE-YGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSG 3055
            G +P C+P  C  P    +G  NG++F+        C  G+ L G+S   C ++GQWSS 
Sbjct: 2729 GQTPVCVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSP 2788

Query: 3056 FPHCEHTSCGSLPMIPNAFISETSSWKENV-----ITYSCRSGYVIQGSSDLICTEKGVW 3110
             P C   +C     + NA      ++ E+      I Y C+ G+ + GSS L C   G+W
Sbjct: 2789 LPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLW 2848

Query: 3111 SQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRW- 3169
             +  P C  +SCG P   ANAV TGE  TY + V   C  G       DT  CQ+D  W 
Sbjct: 2849 DRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSC-RGSESLIGNDTRVCQEDSHWS 2907

Query: 3170 --FPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTW 3227
               P     +P  C  P    H    GDDF     +  SC  G+   G     C L+G+W
Sbjct: 2908 GALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSW 2967

Query: 3228 EPPFSDESCSPVSCGKPESPEHGFVVGSK-YTFESTIIYQCEPGYELEGNRERVCQENRQ 3286
                    C  VSCG P +P +G +V S    F S++IY C  GY+  G   R C  N  
Sbjct: 2968 SG--LQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGT 3025

Query: 3287 WSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEA--HCTENGT 3344
            W+G    C    C  P    NG     + T    V Y CN GY +E  + A   CT++G 
Sbjct: 3026 WTGTAPDCTIISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGR 3085

Query: 3345 WSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETW 3404
            W+   P+CK   CP P  + +N  +   +F    ++S  C +G+ L    I++C     W
Sbjct: 3086 WNPSKPVCKAVLCPQPPPV-QNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVW 3144

Query: 3405 TQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTS 3464
                 +C  + CG P         G  + Y   + + C S ++L G  R VC  +GTW+ 
Sbjct: 3145 KGEIPQCLPVFCGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSG 3204

Query: 3465 -PPICRAVCRFPCQNGG 3480
              P C       C + G
Sbjct: 3205 IQPTCIDPAHNTCPDPG 3221



 Score =  440 bits (1132), Expect = e-122
 Identities = 335/1176 (28%), Positives = 488/1176 (41%), Gaps = 135/1176 (11%)

Query: 1690 CGVPP--PLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFC--TDNGSWNGVSPSCLD 1745
            C  PP  P        DDF  G  V YQC+ GY L+G   + C  +    + G  P+C  
Sbjct: 2259 CQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTC-- 2316

Query: 1746 VDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIY 1805
                   + C  +       G  +    P    + + C+  IK +      N + +  + 
Sbjct: 2317 ------EAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEP-----NYNITIFVD 2365

Query: 1806 TVGAEVTFSCQEGYQ-LMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFT 1864
            T  +E  F   E +    G + +  + SG  NH                          T
Sbjct: 2366 TFQSEKQFDALEVFDGSSGQSPLLVVLSG--NH--------------------------T 2397

Query: 1865 FGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCE---PVKCSSPENINNGKYILSGL 1921
              S  T R N+ Y       ++        ++ P C    P+K       N G    +  
Sbjct: 2398 EQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYCSLTHPLK-------NGGILNRTAG 2450

Query: 1922 TYLSTASYSCDTGYSLQGPSIIECTASGI----WDRAPPACHLVFCGEPPAIKDAVITGN 1977
               S   Y C  GY + G S   C  + +    WD   P C  V CG P +  +   TGN
Sbjct: 2451 AVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTGN 2510

Query: 1978 NFTFRNTVTYTCKEGYTLAGLD--TIECLADGKWSRSDQQ--CLAVSCDEPPIVDHASPE 2033
             FT  + V Y C EG+ L      T  C  DG WS   +   C  V+C  P I    S  
Sbjct: 2511 EFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVAC--PSIEAQLSEH 2568

Query: 2034 TAHRL-------FGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKP 2086
               RL       +G      CS GY L     L C A G W    G + P C    C   
Sbjct: 2569 VIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTW--NIGDERPSCRVISCG-- 2624

Query: 2087 PSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRC 2146
             S+S+    +        G+   F C  G+ L  S   EC+  G W+ S    +C+   C
Sbjct: 2625 -SLSFPPNGNKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGS--ETRCLAGHC 2681

Query: 2147 GEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGE 2206
            G P  I+NG+ SG  +S+   V Y CN GF + G     C    +WS   P C P++CG 
Sbjct: 2682 GSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGH 2741

Query: 2207 PPKVENGFLEHTTGRIFESE--VRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDC 2264
            P    +GF   T G  F     V + CN GY   G     C++N  W S  P  C  ++C
Sbjct: 2742 PGNPAHGF---TNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPT-CRVVNC 2797

Query: 2265 GKPPPIQNGFMKG-----ENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCM 2319
              P  ++N    G     E+FE G  + + C +G+ L+G S+ TC  +G W++ S PKC+
Sbjct: 2798 SDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDR-SLPKCL 2856

Query: 2320 PAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVC--- 2376
               C  P +  N ++  EL T   VV +SC+    L G     C     W+ + P C   
Sbjct: 2857 AISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGN 2916

Query: 2377 KIVLCTPPPLISFGVPIPSSAL----HFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPL 2432
                C  P     G P   S L       S +++SC  G  LRG+    C  +G+WS   
Sbjct: 2917 NPGFCGDP-----GTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQ 2971

Query: 2433 PECVPVECPQPEEIPNG-IIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKP 2491
            P C  V C  P    NG I+   G+ + S+ +Y C  G++  G  T  C  NG W G  P
Sbjct: 2972 PVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAP 3031

Query: 2492 TCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALT--CLETGDWDVDAP 2549
             C  I C  P  + NG    TD  + +TV+Y CN G+ +E  ++ T  C + G W+   P
Sbjct: 3032 DCTIISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKP 3091

Query: 2550 SCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPTC 2608
             C A+ C  P P++NG VEG+D+ +G+ I YSC  G+Q++  A+ +CE  G W   IP C
Sbjct: 3092 VCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQC 3151

Query: 2609 MPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMM-EVPYVTPHPPYHLGAVAKTWE----- 2662
            +P+ CG P     G   +L      ++ E     + P++       +     TW      
Sbjct: 3152 LPVFCGDPGIPAEG---RLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPT 3208

Query: 2663 ------NTKESPAT-------HSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSA 2709
                  NT   P T        S  +  G+ V + C  GY + G+    C  + TW+G  
Sbjct: 3209 CIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQ 3268

Query: 2710 PSCISIECDLPTAPENGFLRFTET-SMGSAVQYSCKPGHILAG-SDLRLCLENRKWSGAS 2767
              CI   C  P  P +  +R  +  + G  + Y+C PG  LAG S+ R C  + KW+G S
Sbjct: 3269 TECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKS 3328

Query: 2768 PRCEAISCKKPNPVMNGSIKGSNYTYLSTL---YYE 2800
            P C++   ++ N  +  +   S+  ++++L   YYE
Sbjct: 3329 PVCKSKGVREVNETVTKTPVPSDVFFVNSLWKGYYE 3364



 Score =  353 bits (907), Expect = 1e-96
 Identities = 371/1620 (22%), Positives = 571/1620 (35%), Gaps = 232/1620 (14%)

Query: 2020 SCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCI 2079
            +C +P  + + +        G    Y C  GY + D S + C       P   Q +P C 
Sbjct: 1564 ACFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCN 1623

Query: 2080 AHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSI 2139
            A    +       +L       + AG +  +        + +   E +  GQ+     ++
Sbjct: 1624 APCGGQYTGSEGVVLSPNYPHNYTAGQICLY--------SITVPKEFVVFGQFAYFQTAL 1675

Query: 2140 QCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWS--SPIP 2197
              +        +     +S S    G  +  + +    ++   KS   A G       +P
Sbjct: 1676 NDLAELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVP 1735

Query: 2198 TCHPVSCGEPPKVENGFL---EHTTGRIFESEVRYQCNPGYKSVGSPVFVCQ----ANRH 2250
                  C   P+   G     E + G I    VR++CNPGY   GS    CQ    A   
Sbjct: 1736 RTSDTQCSSVPEPRYGRRIGSEFSAGSI----VRFECNPGYLLQGSTALHCQSVPNALAQ 1791

Query: 2251 WHSESPLMCVP------------LDCGKPPPIQNGF------MKGENFEVGSKVQFFCNE 2292
            W+   P   VP            L  G P P  N        +  E   +  +V  F  E
Sbjct: 1792 WNDTIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATE 1851

Query: 2293 ----GYELVGDSSWTCQKSGKWNKKSNPKCMP---------------------------- 2320
                  E+      T  + G ++  + P  +                             
Sbjct: 1852 QNWDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTV 1911

Query: 2321 --AKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPS--QQWNDSFPVC 2376
              A C EP L  N + + +      V++F C+ G+ LQG S + C+P   ++WN   P+C
Sbjct: 1912 GLAACQEPALPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLC 1971

Query: 2377 KIVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGN--STTLCQPDGTWSSPLPE 2434
             I  C                   G T+  S +GG  L      +     D TW   LP 
Sbjct: 1972 -IATC-------------------GGTL--STLGGVILSPGFPGSYPNNLDCTWRISLPI 2009

Query: 2435 CVPVECPQ---PEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGE--------- 2482
                         E  +  +++Q   Y ++ +     G +L     +   E         
Sbjct: 2010 GYGAHIQFLNFSTEANHDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDH 2069

Query: 2483 NGHWLGGKPTCKAIE---CLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCL 2539
            + +  G K   +A E   C  P    NG    +D   GQ+V++ C  G+ L G   LTC 
Sbjct: 2070 SQNRQGFKLAYQAYELQNCPDPPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQ 2129

Query: 2540 E--TGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCF------PGF----- 2586
                 +W+   P C+A  C      +NG +    +     I+  C       PG      
Sbjct: 2130 HGINRNWNYPFPRCDA-PCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYIN 2188

Query: 2587 ------------------------QVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFG 2622
                                    Q+   +  T  E+ +SS+    +        H DF 
Sbjct: 2189 FTLLQTEAVNDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKF------HSDFS 2242

Query: 2623 DCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVS 2682
            +        G+F       ++    P P              +    T   +F  G  V 
Sbjct: 2243 N-------GGFFVLNFHAFQLKKCQPPPAV-----------PQAEMLTEDDDFEIGDFVK 2284

Query: 2683 YTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYS 2742
            Y C+PGY L+G  +L C+          S +  E  LPT           T     +   
Sbjct: 2285 YQCHPGYTLVGTDILTCK--------LSSQLQFEGSLPTCEAQCPANEVRTGSSGVILSP 2336

Query: 2743 CKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNP---VMNGS--------IKGSNY 2791
              PG+          ++       +   +    +K      V +GS        +   N+
Sbjct: 2337 GYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNH 2396

Query: 2792 TYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTF 2851
            T  S      +  Y+   T+  T +         P C      + P+   G +       
Sbjct: 2397 TEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYC----SLTHPLKNGGILNRTAGAV 2452

Query: 2852 QKEIEYTCNEGFLLEGARSRVCLANG----SWSGATPDCVPVRCATPPQLANGVTEGLDY 2907
              ++ Y C  G+ + G  +  C  N      W   TP C  V C  P    NG   G ++
Sbjct: 2453 GSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTGNEF 2512

Query: 2908 GFMKEVTFHCHEGYILHGAPKLT--CQSDGNWD--AEIPLCKPVNCGP-----PEDLAHG 2958
                +V + CHEG+ L  + + T  CQ DG W    + P CKPV C        E +   
Sbjct: 2513 TLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSEHVIWR 2572

Query: 2959 FPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWS--GSSPSCLPCRC-STPVIEYG 3015
              +G    +G  +   C PGY L G    RC +NG+W+     PSC    C S      G
Sbjct: 2573 LVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNG 2632

Query: 3016 TVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFI 3075
               GT    G  A   C  G+ L+G     C A+G WS     C    CGS   I N  I
Sbjct: 2633 NKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNGHI 2692

Query: 3076 SETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATG 3135
            S       + + Y C  G+ + G+S  IC +   WS   PVC P++CG P + A+    G
Sbjct: 2693 SGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNG 2752

Query: 3136 EAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHG- 3194
                    V   C  GY +        C+ +G+W     +C    C  P  + + + HG 
Sbjct: 2753 SEFNLNDVVNFTCNTGYLLQ-GVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQ 2811

Query: 3195 ----DDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHG 3250
                + F     +   C +G+   G +   C  +G W+   S   C  +SCG P  P + 
Sbjct: 2812 QNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDR--SLPKCLAISCGHPGVPANA 2869

Query: 3251 FVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETR---CETPLEFLN 3307
             + G  +T+ + + Y C     L GN  RVCQE+  WSG +  C       C  P    +
Sbjct: 2870 VLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAH 2929

Query: 3308 GKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENA 3367
            G    ++  T   + +SC  G+ L G  E  C  NG+WS   P+C+   C  P       
Sbjct: 2930 GSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGM 2989

Query: 3368 LLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIA 3427
            ++S        +V   C EG+   G     C  + TWT T+  C  ISCG P  + N I 
Sbjct: 2990 IVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANGIQ 3049

Query: 3428 RGVHYQYGDMITYSCYSGYMLEGFLRSV--CLENGTWT-SPPICRAVC---RFPCQNGGI 3481
             G  + +   ++Y C  GY++E    +   C ++G W  S P+C+AV      P QNG +
Sbjct: 3050 FGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTV 3109



 Score =  300 bits (767), Expect = 2e-80
 Identities = 176/597 (29%), Positives = 272/597 (45%), Gaps = 41/597 (6%)

Query: 1636 GSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPP 1695
            G+  H  T   +      VN  C+ G+ L G     C + GQW+ PLP C  ++C  P  
Sbjct: 2743 GNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGF 2802

Query: 1696 LENGFHSA-----DDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECA 1750
            +EN          + F  G ++ Y C  G+YLLG S + C  NG W+   P CL +    
Sbjct: 2803 VENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGH 2862

Query: 1751 VGSDCSE-------------HASC-----LNVDGSYICSCVPPYTGDGKNCA--EPIKCK 1790
             G   +              H SC     L  + + +C     ++G   +C    P  C 
Sbjct: 2863 PGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCG 2922

Query: 1791 APGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKP 1850
             PG P +G   G+ +   + + FSC+ G+QL G  + TCL +G W+ L P C+AVSCG P
Sbjct: 2923 DPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNP 2982

Query: 1851 AIPENGCI-EELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPE 1909
              P NG I       F S V Y C +GY  +G     C AN +W+ + P C  + C  P 
Sbjct: 2983 GTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPG 3042

Query: 1910 NINNGKYILSGLTYLSTASYSCDTGYSLQG--PSIIECTASGIWDRAPPACHLVFCGEPP 1967
             + NG    +  T+  T SY C+ GY ++    + I CT  G W+ + P C  V C +PP
Sbjct: 3043 TLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPP 3102

Query: 1968 AIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIV 2027
             +++  + G++F + ++++Y+C +GY L+    + C   G W     QCL V C +P I 
Sbjct: 3103 PVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIP 3162

Query: 2028 DHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCI--AH-FCE 2084
                       +    F+ C   + L  +S+ +C A G W        P CI  AH  C 
Sbjct: 3163 AEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTW----SGIQPTCIDPAHNTCP 3218

Query: 2085 KPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPV 2144
             P +  + I    S   +  GS V F+C +G+ +  S    C+    W  S +  +CIP 
Sbjct: 3219 DPGTPHFGIQN--SSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTW--SGIQTECIPH 3274

Query: 2145 RCGEPPSIMNGYASGSNY-SFGAMVAYSCNKGFYIK-GEKKSTCEATGQWSSPIPTC 2199
             C +P +  +      +  +FG  + Y+C+ GF++  G +  TC+A  +W+   P C
Sbjct: 3275 ACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVC 3331



 Score =  203 bits (516), Expect = 3e-51
 Identities = 136/451 (30%), Positives = 180/451 (39%), Gaps = 56/451 (12%)

Query: 1627 FCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCE 1686
            FC D     G+  H     +D K  S +   C+ G QL G+P + CL  G W+   P CE
Sbjct: 2920 FCGD----PGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCE 2975

Query: 1687 RISCGVPPPLENG-FHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLD 1745
             +SCG P    NG   S+D     S+V Y C  GY   G     CT NG+W G +P C  
Sbjct: 2976 AVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDC-- 3033

Query: 1746 VDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIY 1805
                                                     I C  PG   NG   G  +
Sbjct: 3034 ---------------------------------------TIISCGDPGTLANGIQFGTDF 3054

Query: 1806 TVGAEVTFSCQEGYQLMGVTKIT--CLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAF 1863
            T    V++ C  GY +  VT  T  C + G WN   P CKAV C +P   +NG +E   F
Sbjct: 3055 TFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDF 3114

Query: 1864 TFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTY 1923
             +GS ++Y C  GY L+     SC     W    P C PV C  P     G+      TY
Sbjct: 3115 RWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLSGKSFTY 3174

Query: 1924 LSTASYSCDTGYSLQGPSIIECTASGIWDRAPPAC----HLVFCGEPPAIKDAV-ITGNN 1978
             S   + C + + L G S   C A G W    P C    H   C +P      +  +   
Sbjct: 3175 KSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNT-CPDPGTPHFGIQNSSRG 3233

Query: 1979 FTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAH-R 2037
            +   +TV + C++GY + G  T  CLA+  WS    +C+  +C +P    HA        
Sbjct: 3234 YEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLP 3293

Query: 2038 LFGDIAFYYCSDGYSLADNSQ-LLCNAQGKW 2067
             FG    Y C  G+ LA  S+   C A  KW
Sbjct: 3294 TFGYTLVYTCHPGFFLAGGSEHRTCKADMKW 3324



 Score =  169 bits (429), Expect = 3e-41
 Identities = 112/397 (28%), Positives = 160/397 (40%), Gaps = 55/397 (13%)

Query: 1631 CPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISC 1690
            C   G     +  +S+ +   S V   C  G++  G   ++C   G WT   P C  ISC
Sbjct: 2979 CGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISC 3038

Query: 1691 GVPPPLENGFHSADDFYAGSTVTYQCNNGYYL--LGDSRMFCTDNGSWNGVSPSCLDVDE 1748
            G P  L NG     DF    TV+YQCN GY +  +  + + CT +G WN   P C     
Sbjct: 3039 GDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVC----- 3093

Query: 1749 CAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVG 1808
                                                + + C  P   +NG   G  +  G
Sbjct: 3094 ------------------------------------KAVLCPQPPPVQNGTVEGSDFRWG 3117

Query: 1809 AEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSK 1868
            + +++SC +GYQL     ++C   G W   IP C  V CG P IP  G +   +FT+ S+
Sbjct: 3118 SSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLSGKSFTYKSE 3177

Query: 1869 VTYRCNKGYTLAGDKESSCLANSSWSHSPPVC-EPVKCSSPE------NINNGKYILSGL 1921
            V ++C   + L G     C A+ +WS   P C +P   + P+       I N      G 
Sbjct: 3178 VFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSS---RGY 3234

Query: 1922 TYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNF-T 1980
               ST  + C  GY +QG +   C A+  W      C    C +P     A +   +  T
Sbjct: 3235 EVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPT 3294

Query: 1981 FRNTVTYTCKEGYTLA-GLDTIECLADGKWSRSDQQC 2016
            F  T+ YTC  G+ LA G +   C AD KW+     C
Sbjct: 3295 FGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVC 3331



 Score =  125 bits (314), Expect = 7e-28
 Identities = 78/281 (27%), Positives = 121/281 (43%), Gaps = 45/281 (16%)

Query: 1624 KSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLP 1683
            K++ C   P     V +      D + GS ++  C  G+QL  + +  C  +G W   +P
Sbjct: 3094 KAVLCPQPP----PVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIP 3149

Query: 1684 HCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSC 1743
             C  + CG P     G  S   F   S V +QC + + L+G SR  C  +G+W+G+ P+C
Sbjct: 3150 QCLPVFCGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTC 3209

Query: 1744 LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENG-HSSG 1802
            +D                            P +            C  PG P  G  +S 
Sbjct: 3210 ID----------------------------PAHN----------TCPDPGTPHFGIQNSS 3231

Query: 1803 EIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELA 1862
              Y VG+ V F C++GY + G T  TCL +  W+ +   C   +C +P  P +  +  + 
Sbjct: 3232 RGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAID 3291

Query: 1863 F-TFGSKVTYRCNKGYTLAGDKE-SSCLANSSWSHSPPVCE 1901
              TFG  + Y C+ G+ LAG  E  +C A+  W+   PVC+
Sbjct: 3292 LPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCK 3332



 Score = 98.6 bits (244), Expect = 1e-19
 Identities = 292/1425 (20%), Positives = 488/1425 (34%), Gaps = 271/1425 (19%)

Query: 2203 SCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQAN----RHWHSESPLM 2258
            +CG P ++  G L  T   I + ++RY C PGY   G  +  C  +      W   +P  
Sbjct: 144  TCGNPGEILKGVLHGTRFNIGD-KIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFC 202

Query: 2259 CVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTC-------------- 2304
                 CG       G ++G +  + S    F +E YE   D +WT               
Sbjct: 203  RAEGACG-------GTLRGTSSSISSP--HFPSE-YENNADCTWTILAEPGDTIALVFTD 252

Query: 2305 ---QKSGKWNKKSNPKCMPA-----KCPEPPLLENQLVLKELTTEVGV------VTFSCK 2350
               ++   + + S  +           P P +     +    T++           F  K
Sbjct: 253  FQLEEGYDFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVK 312

Query: 2351 EGHVLQGPSVLKCLPSQQWNDSFPVCK-------IVLCTPPPLISFGVPIPSSALHFGST 2403
            +   L+   V K LPS+  +    V           +C  P +   G    S     G+ 
Sbjct: 313  KAIELKSRGV-KMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGAN 371

Query: 2404 VKYSCVGGFFLRGNSTTLCQPD----GTWSSPLPECVPVECPQPEEIPNGII-------D 2452
            V++SC   + L+G+ +  CQ        WS   P C    C      P+G+I        
Sbjct: 372  VQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQ 431

Query: 2453 VQGLAYLSTALYTCKPG---------FELV-GNTTTLCGENGHWLGGKPTCKAIECLKPK 2502
             +  A+    + T  P          FEL  G  T   G+ G         K  +     
Sbjct: 432  YEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAG---------KVGDTRSVL 482

Query: 2503 EILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIH------- 2555
             +L G  S  DL     V+ S      L+           D  + +P   A++       
Sbjct: 483  YVLTGS-SVPDL----IVSMSNQMWLHLQS----------DDSIGSPGFKAVYQEIEKGG 527

Query: 2556 CDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPTCMPIDCG 2614
            C  P     G   G+ + +G  + + C   F++ G  + TC+++  WS + P+     C 
Sbjct: 528  CGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPS-----CV 582

Query: 2615 LPPHIDFGDCTKLKDDQGYFEQEDDMMEVPY-VTPHPPYHLGAVAKTWENTKE------- 2666
                 +F   + +     Y E+  + M   + +   P   +  +   ++   +       
Sbjct: 583  FSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVK 642

Query: 2667 ----SPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISI-----EC 2717
                S  T    F    + S   + G+ +     L  Q D +  G   +         EC
Sbjct: 643  DDGISDITVLGTFSGNEVPSQLASSGHIVR----LEFQSDHSTTGRGFNITYTTFGQNEC 698

Query: 2718 DLPTAPENGFLRFTETSMGSAVQYSCKPGHILA-GSDLRLCL---ENRKWSGASPRCEAI 2773
              P  P NG        +GS+V + C  G +   GS+   C+    N  WS   PRCEA 
Sbjct: 699  HDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEA- 757

Query: 2774 SCKKPNPVMNGSIKGSNYT--YLSTLY----YECDPGYVLNGTERRTCQDDKNWDEDEPI 2827
             C       +G I    +   Y  +L+     E  PG+ +  T  R  Q + N+D  E  
Sbjct: 758  PCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRF-QTEVNYDTLEVR 816

Query: 2828 CIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLL---EGARSRVCLANGSWSGATP 2884
              P   SSP +      +  ++        T N  +LL   + +RS +      +   T 
Sbjct: 817  DGPAS-SSPLIGEYHGTQAPQFLIS-----TGNFMYLLFTTDNSRSSIGFLI-HYESVTL 869

Query: 2885 DCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLC 2944
            +     C  P    NG   G D+G    VTF C  GY L     L C+ +  W+  +P C
Sbjct: 870  ESDS--CLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSC 927

Query: 2945 KPVNCGPPED-----LAHGFPNGF----------SFIHGGHIQYQCFPGYKLHGNSSRRC 2989
              +  G  +      L+ GFP+ +             HG  +Q   F  + L  +     
Sbjct: 928  DALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQ-MIFHTFHLESSHDYLL 986

Query: 2990 LS-NGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEA 3048
            ++ +GS+S       P    T  +   T+    F    A         +L  +S+ +   
Sbjct: 987  ITEDGSFSE------PVARLTGSVLPHTIKAGLFGNFTA---------QLRFISDFSISY 1031

Query: 3049 DGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENV---ITYSCRSGYVIQGSSDLICT 3105
            +G ++  F   +   C   P +P AF S    +   V   +T+SC  GY ++G++ L C 
Sbjct: 1032 EG-FNITFSEYDLEPCDD-PGVP-AF-SRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCL 1087

Query: 3106 EKG--VWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTC 3163
              G  VWS P P C    CG+                  +    C+  Y ++T+      
Sbjct: 1088 GGGRRVWSAPLPRCVA-ECGASVKGNEGTLLSPNFPSNYDNNHECI--YKIETEAG---- 1140

Query: 3164 QKDGRWFPERISCSPKKCPLPENITHILVHGDD--------FSVNRQVSV--SCAEGYTF 3213
                    + I    +   L E  T  +  G D        F+ N  + +  +    + +
Sbjct: 1141 --------KGIHLRTRSFQLFEGDTLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLW 1192

Query: 3214 EGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTII-YQCEPGYE 3272
               N +    D  ++  ++  S   V C  P  P +G+ +  +  F  T++ Y C PGY 
Sbjct: 1193 LEFNTNGSDTDQGFQLTYT--SFDLVKCEDPGIPNYGYRIRDEGHFTDTVVLYSCNPGYA 1250

Query: 3273 LEGNRERVC--QENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYS 3330
            + G+    C   + R W   +  C    C   +      A    R   P        GY 
Sbjct: 1251 MHGSNTLTCLSGDRRVWDKPLPSC-IAECGGQIH-----AATSGRILSP--------GYP 1296

Query: 3331 LEGPSEAHCT-----------------ENGTWSHPVPLCKPNPCPVPFVIPE--NALLSE 3371
                +  HCT                  +   +H +      P     ++ E   + L E
Sbjct: 1297 APYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPE 1356

Query: 3372 KEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVH 3431
                   +++++    F +   G       +  T  +A     +C  P   +N    G  
Sbjct: 1357 DIHSTFNSLTLQFDSDFFISKSGFSI----QFSTSIAA-----TCNDPGMPQNGTRYGDS 1407

Query: 3432 YQYGDMITYSCYSGYMLEGFLRSVCLENGT---W-TSPPICRAVC 3472
             + GD +T+ C  GY L+G  +  C++      W   PP C A C
Sbjct: 1408 REAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAAC 1452



 Score = 92.4 bits (228), Expect = 7e-18
 Identities = 141/607 (23%), Positives = 222/607 (36%), Gaps = 117/607 (19%)

Query: 1658 CDPGFQLVGNPVQYCLNQGQ--WTQPLPHC--------------ERISCGVPPPLENGFH 1701
            C+PG+ + G+    CL+  +  W +PLP C                +S G P P +N  H
Sbjct: 1245 CNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAECGGQIHAATSGRILSPGYPAPYDNNLH 1304

Query: 1702 SADDFYA--GSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSE-- 1757
                  A  G T++      ++++ D+ M       W+G   S + + E + GS   E  
Sbjct: 1305 CTWIIEADPGKTISL-----HFIVFDTEMAHDILKVWDGPVDSDILLKEWS-GSALPEDI 1358

Query: 1758 ----HASCLNVDGSYICSCVPPYTGDGKNCAEPIK--CKAPGNPENGHSSGEIYTVGAEV 1811
                ++  L  D  +  S     +G     +  I   C  PG P+NG   G+    G  V
Sbjct: 1359 HSTFNSLTLQFDSDFFIS----KSGFSIQFSTSIAATCNDPGMPQNGTRYGDSREAGDTV 1414

Query: 1812 TFSCQEGYQLMGVTKITCLESGE---WNHLIPYCKAVSCGKPAIPENGCI----EELAFT 1864
            TF C  GYQL G  KITC++      W    P C A +CG       G I        + 
Sbjct: 1415 TFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIA-ACGGNLTGPAGVILSPNYPQPYP 1473

Query: 1865 FGSKVTYRCN-----------KGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINN 1913
             G +  +R             K + +    +   +     S+SP +       +PE I +
Sbjct: 1474 PGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPLIGSYQGSQAPERIES 1533

Query: 1914 GKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAV 1973
                L  L + S AS    +G++++            +   P       C +P  I +  
Sbjct: 1534 SGNSLF-LAFRSDASVGL-SGFAIE------------FKEKPREA----CFDPGNIMNGT 1575

Query: 1974 ITGNNFTFRNTVTYTCKEGYTLAGLDTIECL--ADGK--WSRSDQQCLAVSCDEPPIVDH 2029
              G +F   +T+TY C  GY +    +I C+  ADGK  W +     +  SC+ P    +
Sbjct: 1576 RVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQ-----VLPSCNAPCGGQY 1630

Query: 2030 A-------SPETAHR-LFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAH 2081
                    SP   H    G I        YS+    + +   Q  +      D+      
Sbjct: 1631 TGSEGVVLSPNYPHNYTAGQICL------YSITVPKEFVVFGQFAYFQTALNDLAELF-- 1682

Query: 2082 FCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGG-----QWNPSP 2136
                       +L S+S +   +G  +        +L  SAK      G     Q  P  
Sbjct: 1683 ---DGTHAQARLLSSLSGSH--SGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRT 1737

Query: 2137 MSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCE----ATGQW 2192
               QC  V     P    G   GS +S G++V + CN G+ ++G     C+    A  QW
Sbjct: 1738 SDTQCSSV-----PEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQW 1792

Query: 2193 SSPIPTC 2199
            +  IP+C
Sbjct: 1793 NDTIPSC 1799



 Score = 92.0 bits (227), Expect = 9e-18
 Identities = 55/193 (28%), Positives = 84/193 (43%), Gaps = 5/193 (2%)

Query: 359  DCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSII 418
            +C+    +  S   C   HC +  P  NG+   +  +  +      +C+PGF LVG+S+ 
Sbjct: 2662 ECLANGLWSGSETRCLAGHCGSPDPIVNGHISGDGFS--YRDTVVYQCNPGFRLVGTSVR 2719

Query: 419  LCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKL 478
            +CL +  WSG    C   TC H   P HG  + S  E          C+ GY L+G  + 
Sbjct: 2720 ICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGS--EFNLNDVVNFTCNTGYLLQGVSRA 2777

Query: 479  TCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGV 538
             C+ N QW  P P C   +CS     ++ I        +  ++G      C++GF L G 
Sbjct: 2778 QCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLG- 2836

Query: 539  KEMLRCTTSGKWN 551
               L C  +G W+
Sbjct: 2837 SSALTCMANGLWD 2849



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 53/180 (29%), Positives = 80/180 (44%), Gaps = 10/180 (5%)

Query: 372  TCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSES 431
            +C ++ C +L  P NG  I       + A     C+ G+ LVGS +  CL NGLWSGSE+
Sbjct: 2617 SCRVISCGSLSFPPNGNKIGTL--TVYGATAIFTCNTGYTLVGSHVRECLANGLWSGSET 2674

Query: 432  YCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEP 491
             C    C       +GHIS       Y+ T +  C+ G+RL G+    C  + +W G  P
Sbjct: 2675 RCLAGHCGSPDPIVNGHISGD--GFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTP 2732

Query: 492  RCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
             CV   C     P     +             +   +C  G++L GV    +C ++G+W+
Sbjct: 2733 VCVPITCGHPGNPAHGFTN-----GSEFNLNDVVNFTCNTGYLLQGVSR-AQCRSNGQWS 2786



 Score = 83.2 bits (204), Expect = 4e-15
 Identities = 118/518 (22%), Positives = 176/518 (33%), Gaps = 99/518 (19%)

Query: 2534 SALTCLETGDWDVDAPSCNAIH-------CDSPQPIENGFVEGADYSYGAIIIYSCFPGF 2586
            S LT   T D+ V A    A++       C +P  I  G + G  ++ G  I YSC PG+
Sbjct: 116  SILTLWFTTDFAVSAQGFKALYEVLPSHTCGNPGEILKGVLHGTRFNIGDKIRYSCLPGY 175

Query: 2587 QVAGHAMQTCEES-----GWSSSIPTCMPID-CGLPPHIDFGDCTKLKDDQGYFEQEDDM 2640
             + GHA+ TC  S      W    P C     CG                 G        
Sbjct: 176  ILEGHAILTCIVSPGNGASWDFPAPFCRAEGACG-----------------GTLRGTSSS 218

Query: 2641 MEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQ 2700
            +  P+    P  +      TW    E   T +  F       +    GY+ L       +
Sbjct: 219  ISSPHF---PSEYENNADCTWTILAEPGDTIALVF-----TDFQLEEGYDFL-------E 263

Query: 2701 EDGTWNGSAPSCISIECDLPTA--PENGFLRFTETS------MGSAVQYSCKPGHILAGS 2752
              GT    APS      +LP+       +LR   TS       G   Q+  K    L   
Sbjct: 264  ISGT---EAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKSR 320

Query: 2753 DLRLCL------ENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYL-STLYYECDPGY 2805
             +++        +N   S       +  C  P    NG   GS+++ + + + + C+  Y
Sbjct: 321  GVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCEDNY 380

Query: 2806 VLNGTERRTCQDDKN----WDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCN- 2860
            VL G++  TCQ        W +  PIC    C S     +G +    Y  Q E    C  
Sbjct: 381  VLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVW 440

Query: 2861 ---------------EGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGL 2905
                           E F LE     + + +    G T   + V       L       L
Sbjct: 441  VITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYV-------LTGSSVPDL 493

Query: 2906 DYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSF 2965
                  ++  H      + G+P         + A     +   CG P   A+G   G SF
Sbjct: 494  IVSMSNQMWLHLQSDDSI-GSP--------GFKAVYQEIEKGGCGDPGIPAYGKRTGSSF 544

Query: 2966 IHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCL 3003
            +HG  + ++C   ++L G     C  N  WSG+ PSC+
Sbjct: 545  LHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCV 582



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 67/233 (28%), Positives = 94/233 (40%), Gaps = 29/233 (12%)

Query: 361  VCREGYRASGQTCELVHCPALKP--------PENGYFIQNTCNNHFNAACGVR--CHPGF 410
            VC+E    SG    L HC    P        P +G    +   + F     +R  C  G 
Sbjct: 2899 VCQEDSHWSGA---LPHCTGNNPGFCGDPGTPAHG----SRLGDDFKTKSLLRFSCEMGH 2951

Query: 411  DLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGY 470
             L GS    CL NG WSG +  C   +C +   P +G I  S+  +L+ ++ + AC EGY
Sbjct: 2952 QLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMI-VSSDGILFSSSVIYACWEGY 3010

Query: 471  RLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCR 530
            +  G     C  N  W G  P C    C         + +    G       T+ Y  C 
Sbjct: 3011 KTSGLMTRHCTANGTWTGTAPDCTIISCG----DPGTLANGIQFGTDFTFNKTVSY-QCN 3065

Query: 531  QGFILSGV-KEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQD 582
             G+++  V    +RCT  G+WN      VCK V  PQ   P  ++  T+E  D
Sbjct: 3066 PGYVMEAVTSATIRCTKDGRWN--PSKPVCKAVLCPQ---PPPVQNGTVEGSD 3113



 Score = 76.3 bits (186), Expect = 5e-13
 Identities = 50/167 (29%), Positives = 70/167 (41%), Gaps = 10/167 (5%)

Query: 405  RCHPGFDLVGSSIILCLPNGLWSGSESYC---RVRTCPHLRQPKHGHISCSTREMLYKTT 461
            +C   F LVGSS  +C  +G WSG +  C      TCP    P  G I  S+R     +T
Sbjct: 3181 QCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFG-IQNSSRGYEVGST 3239

Query: 462  CLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKF 521
                C +GY ++GS   TC  N  W G +  C+   C   + P    +   +       F
Sbjct: 3240 VFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDL----PTF 3295

Query: 522  GTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQIN 568
            G     +C  GF L+G  E   C    KW    ++ VCK     ++N
Sbjct: 3296 GYTLVYTCHPGFFLAGGSEHRTCKADMKWT--GKSPVCKSKGVREVN 3340



 Score = 73.9 bits (180), Expect = 3e-12
 Identities = 56/212 (26%), Positives = 93/212 (43%), Gaps = 29/212 (13%)

Query: 362  CREGYRASG----------------QTCELVHCPALKPPENGYFIQNTCNNHFNAACGVR 405
            C EGY+ SG                  C ++ C       NG  IQ   +  FN     +
Sbjct: 3006 CWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANG--IQFGTDFTFNKTVSYQ 3063

Query: 406  CHPGF--DLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCL 463
            C+PG+  + V S+ I C  +G W+ S+  C+   CP     ++G +  S  +  + ++  
Sbjct: 3064 CNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGS--DFRWGSSIS 3121

Query: 464  VACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGT 523
             +C +GY+L  S  L+C+G   W G  P+C+   C    +P +  +S    GK    + +
Sbjct: 3122 YSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLS----GKS-FTYKS 3176

Query: 524  ICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQ 555
              +  C+  FIL G    + C   G W+ G+Q
Sbjct: 3177 EVFFQCKSPFILVGSSRRV-CQADGTWS-GIQ 3206



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 148/701 (21%), Positives = 242/701 (34%), Gaps = 167/701 (23%)

Query: 1680 QPLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTD----NGS 1735
            Q +P      C   P    G     +F AGS V ++CN GY L G + + C         
Sbjct: 1732 QAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQ 1791

Query: 1736 WNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCA-EPIKCKAPG- 1793
            WN   PSC+          CS   +     G+ +    P   G+  NC  + I  +  G 
Sbjct: 1792 WNDTIPSCV--------VPCS--GNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGI 1841

Query: 1794 -------NPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKA-- 1844
                     E    S EI+  G +VT      +     T +  L +   N L  + ++  
Sbjct: 1842 QIQVISFATEQNWDSLEIHD-GGDVTAPRLGSF---SGTTVPALLNSTSNQLYLHFQSDI 1897

Query: 1845 ----------------VSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCL 1888
                             +C +PA+P N       +     ++++C  GYTL G    SC+
Sbjct: 1898 SVAAAGFHLEYKTVGLAACQEPALPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCM 1957

Query: 1889 ANS--SWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECT 1946
              +   W++  P+C                   G T  +        G+    P+ ++CT
Sbjct: 1958 PGTVRRWNYPSPLC---------------IATCGGTLSTLGGVILSPGFPGSYPNNLDCT 2002

Query: 1947 ASGIWDRAPP---ACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIEC 2003
                W  + P     H+ F               NF+             T A  D +E 
Sbjct: 2003 ----WRISLPIGYGAHIQFL--------------NFS-------------TEANHDFLE- 2030

Query: 2004 LADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNA 2063
            + +G +  S         D P  +   + ET       I FY        +D+SQ   N 
Sbjct: 2031 IQNGPYHTSPMIGQFSGTDLPAALLSTTHETL------IHFY--------SDHSQ---NR 2073

Query: 2064 QGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAK 2123
            QG  +  +  ++  C     + PP  +  ++ S     ++ G  VSF+C  G++L     
Sbjct: 2074 QGFKLAYQAYELQNC----PDPPPFQNGYMINS----DYSVGQSVSFECYPGYILIGHPV 2125

Query: 2124 IECMRG--GQWN-PSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNK------ 2174
            + C  G    WN P P        RC  P        +G+ YS G    Y   K      
Sbjct: 2126 LTCQHGINRNWNYPFP--------RCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLI 2177

Query: 2175 ------GFYIKG---EKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFES 2225
                  G YI     + ++  +    W  P      +       V +G     T     +
Sbjct: 2178 TVPPGHGVYINFTLLQTEAVNDYIAVWDGPDQNSPQLG------VFSGNTALETAYSSTN 2231

Query: 2226 EVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFM--KGENFEVG 2283
            +V  + +  + + G  V       ++H+     C P     PP +    M  + ++FE+G
Sbjct: 2232 QVLLKFHSDFSNGGFFVL------NFHAFQLKKCQP-----PPAVPQAEMLTEDDDFEIG 2280

Query: 2284 SKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCP 2324
              V++ C+ GY LVG    TC+ S +   + +     A+CP
Sbjct: 2281 DFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEAQCP 2321



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 55/225 (24%), Positives = 91/225 (40%), Gaps = 19/225 (8%)

Query: 356  SPEDCVCREGY--RASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLV 413
            S +    ++G+  R +   C L H     P +NG  +  T      +     C PG+ +V
Sbjct: 2414 STDHATSKKGFKIRYAAPYCSLTH-----PLKNGGILNRTAGA-VGSKVHYFCKPGYRMV 2467

Query: 414  GSSIILCLPNGL----WSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEG 469
            G S   C  N L    W      C+  +C     P +G  S +  E    +  +  C EG
Sbjct: 2468 GHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNG--SFTGNEFTLDSKVVYECHEG 2525

Query: 470  YRLEGSDKLT--CQGNSQWD--GPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTIC 525
            ++LE S + T  CQ +  W   G  P C    C + +      +          ++G   
Sbjct: 2526 FKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQV 2585

Query: 526  YVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCP 570
             +SC  G+ L G + +LRC  +G WN+G +   C+ +    ++ P
Sbjct: 2586 LLSCSPGYYLEGWR-LLRCQANGTWNIGDERPSCRVISCGSLSFP 2629



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 134/589 (22%), Positives = 199/589 (33%), Gaps = 122/589 (20%)

Query: 1652 SKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGV-----PPPLENGFHSADDF 1706
            S V   CDPG+ L  +    C    QW   LP C+ +  G         L  GF    DF
Sbjct: 894  STVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCGGYIQGKSGTVLSPGF---PDF 950

Query: 1707 YAGS---TVTYQCNNG----------YYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGS 1753
            Y  S   T T + ++G          +       +  T++GS++   P           +
Sbjct: 951  YPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFS--EPVARLTGSVLPHT 1008

Query: 1754 DCSEHASCLNVDGSYICSCVPPYTGDGKNCAE--PIKCKAPGNPENGHSSGEIYTVGAEV 1811
              +           +I      Y G     +E     C  PG P      G  + VG  +
Sbjct: 1009 IKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLEPCDDPGVPAFSRRIGFHFGVGDSL 1068

Query: 1812 TFSCQEGYQLMGVTKITCLESGE--WNHLIPYCKAVSCG-----------KPAIPEN--- 1855
            TFSC  GY+L G TK+TCL  G   W+  +P C A  CG            P  P N   
Sbjct: 1069 TFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVA-ECGASVKGNEGTLLSPNFPSNYDN 1127

Query: 1856 --GCIEELAFTFGSKVTYRCNKGYTLAGD-------KESS--------------CLANSS 1892
               CI ++    G  +  R        GD       K+SS               + NS+
Sbjct: 1128 NHECIYKIETEAGKGIHLRTRSFQLFEGDTLKVYDGKDSSSRPLGTFTKNELLGLILNST 1187

Query: 1893 WSH------------------SPPVCEPVKCSSPENINNGKYILSGLTYLST-ASYSCDT 1933
             +H                  +    + VKC  P   N G  I     +  T   YSC+ 
Sbjct: 1188 SNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCEDPGIPNYGYRIRDEGHFTDTVVLYSCNP 1247

Query: 1934 GYSLQGPSIIECTASG--IWDRAPPACHLVFCGEPPAIKDAVITGNNF--TFRNTVTYT- 1988
            GY++ G + + C +    +WD+  P+C     G+  A     I    +   + N +  T 
Sbjct: 1248 GYAMHGSNTLTCLSGDRRVWDKPLPSCIAECGGQIHAATSGRILSPGYPAPYDNNLHCTW 1307

Query: 1989 ---CKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDH----ASPETAHRLFGD 2041
                  G T++ L  I  + D + +    +      D   ++      A PE  H  F  
Sbjct: 1308 IIEADPGKTIS-LHFI--VFDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTFNS 1364

Query: 2042 IAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAK 2101
            +   + SD +       +                   IA  C  P           S+  
Sbjct: 1365 LTLQFDSDFFISKSGFSI--------------QFSTSIAATCNDPGMPQNGTRYGDSR-- 1408

Query: 2102 FAAGSVVSFKCMEGFVLNTSAKIECMRGGQ---WNPSPMSIQCIPVRCG 2147
              AG  V+F+C  G+ L   AKI C++      W P P +  CI   CG
Sbjct: 1409 -EAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPT--CI-AACG 1453



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 66/284 (23%), Positives = 108/284 (38%), Gaps = 32/284 (11%)

Query: 307  CEKGYYGKGLQYE-CTA-------CPSGTYKPEGSPGGISSCIPCPDE-------NHTSP 351
            C +GY   GL    CTA        P  T    G PG +++ I    +       ++   
Sbjct: 3006 CWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTFNKTVSYQCN 3065

Query: 352  PG------STSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVR 405
            PG      +++   C     +  S   C+ V CP   P +NG       +  + ++    
Sbjct: 3066 PGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTV--EGSDFRWGSSISYS 3123

Query: 406  CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA 465
            C  G+ L  S+I+ C   G+W G    C    C     P  G +S   +   YK+     
Sbjct: 3124 CMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLS--GKSFTYKSEVFFQ 3181

Query: 466  CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTIC 525
            C   + L GS +  CQ +  W G +P C++   +T   P        N   +  + G+  
Sbjct: 3182 CKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQN-SSRGYEVGSTV 3240

Query: 526  YVSCRQGFILSGVKEMLRCTTSGKWNVGVQAA----VCKDVEAP 565
            +  CR+G+ + G      C  +  W+ G+Q       C+  E P
Sbjct: 3241 FFRCRKGYHIQG-STTRTCLANLTWS-GIQTECIPHACRQPETP 3282



 Score = 69.7 bits (169), Expect = 5e-11
 Identities = 53/196 (27%), Positives = 81/196 (41%), Gaps = 13/196 (6%)

Query: 361  VCREGYRASGQT--CELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSII 418
            +C + ++ SGQT  C  + C     P +G+   N    + N      C+ G+ L G S  
Sbjct: 2720 ICLQDHKWSGQTPVCVPITCGHPGNPAHGF--TNGSEFNLNDVVNFTCNTGYLLQGVSRA 2777

Query: 419  LCLPNGLWSGSESYCRVRTC--PHLRQPKHGHISCSTREML-YKTTCLVACDEGYRLEGS 475
             C  NG WS     CRV  C  P   +    H   +  E   Y  + L  C +G+ L GS
Sbjct: 2778 QCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGS 2837

Query: 476  DKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFIL 535
              LTC  N  WD   P+C+   C    +P + +++      +   +G + + SCR    L
Sbjct: 2838 SALTCMANGLWDRSLPKCLAISCGHPGVPANAVLT-----GELFTYGAVVHYSCRGSESL 2892

Query: 536  SGVKEMLRCTTSGKWN 551
             G  +   C     W+
Sbjct: 2893 IG-NDTRVCQEDSHWS 2907



 Score = 69.3 bits (168), Expect = 6e-11
 Identities = 128/620 (20%), Positives = 205/620 (33%), Gaps = 136/620 (21%)

Query: 1686 ERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLD 1745
            E  SC  P    NG     DF   STVT+ C+ GY L  D  + C  N  WN   PSC  
Sbjct: 870  ESDSCLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSC-- 927

Query: 1746 VDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPE------NGH 1799
                    D           G+ +    P +  +  NC   I+       +      +  
Sbjct: 928  --------DALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLE 979

Query: 1800 SSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVS------------- 1846
            SS +   +  + +FS +   +L G      +++G + +     + +S             
Sbjct: 980  SSHDYLLITEDGSFS-EPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITF 1038

Query: 1847 -------CGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSS--WSHSP 1897
                   C  P +P         F  G  +T+ C  GY L G  + +CL      WS   
Sbjct: 1039 SEYDLEPCDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPL 1098

Query: 1898 PVCEPVKCSS--------------PENINNGKYILSGL-------TYLSTASYSCDTGYS 1936
            P C   +C +              P N +N    +  +        +L T S+    G +
Sbjct: 1099 PRC-VAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDT 1157

Query: 1937 LQGPS--------------------IIECTASGIW--------------DRAPPACHLVF 1962
            L+                       I+  T++ +W                   +  LV 
Sbjct: 1158 LKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVK 1217

Query: 1963 CGEP--PAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGK--WSRSDQQCLA 2018
            C +P  P     +    +FT    V Y+C  GY + G +T+ CL+  +  W +    C+A
Sbjct: 1218 CEDPGIPNYGYRIRDEGHFT-DTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIA 1276

Query: 2019 VSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRC 2078
                          E   ++    +    S GY    ++ L C     W+  E       
Sbjct: 1277 --------------ECGGQIHAATSGRILSPGYPAPYDNNLHCT----WI-IEADPGKTI 1317

Query: 2079 IAHFCEKPPSVSYSIL-------ESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQ 2131
              HF      +++ IL       +S    K  +GS +       F    S  ++      
Sbjct: 1318 SLHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTF---NSLTLQFDSDFF 1374

Query: 2132 WNPSPMSIQ---CIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEA 2188
             + S  SIQ    I   C +P    NG   G +   G  V + C+ G+ ++G+ K TC  
Sbjct: 1375 ISKSGFSIQFSTSIAATCNDPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQ 1434

Query: 2189 TGQ---WSSPIPTCHPVSCG 2205
                  W    PTC   +CG
Sbjct: 1435 LNNRFFWQPDPPTC-IAACG 1453



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 143/635 (22%), Positives = 219/635 (34%), Gaps = 128/635 (20%)

Query: 1698 NGFHSADDFYAGSTVTYQCNNGYYLL-GDSRMFCT---DNGSWNGVSPSCLDVDECAVGS 1753
            NG    D F  GS+V++ C++G+    G   + C     N  W+   P C         +
Sbjct: 706  NGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRC--------EA 757

Query: 1754 DCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNP------------------ 1795
             C  H +  +  G  +    P Y  D  +C   I+ K PG+                   
Sbjct: 758  PCGGHLTASS--GVILPPGWPGYYKDSLHCEWIIEAK-PGHSIKITFDRFQTEVNYDTLE 814

Query: 1796 -ENGHSS-----GEIY-TVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPY----CKA 1844
              +G +S     GE + T   +   S      L+  T  +    G    LI Y     ++
Sbjct: 815  VRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIG---FLIHYESVTLES 871

Query: 1845 VSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVK 1904
             SC  P IP NG      F   S VT+ C+ GYTL+ D+   C  N  W+H+ P C+ + 
Sbjct: 872  DSCLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDAL- 930

Query: 1905 CSSPENINNGKYILSGLTYLSTASYSCD----------------TGYSLQGPSIIECTAS 1948
            C       +G  +  G       S +C                 T +       +  T  
Sbjct: 931  CGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITED 990

Query: 1949 GIWDRAPPACHLVFCGEPPAIKDAVITGN-----NFTFRNTVTYTCKEGYTLAGLDTIEC 2003
            G +    P   L     P  IK A + GN      F    +++Y   EG+ +        
Sbjct: 991  GSFSE--PVARLTGSVLPHTIK-AGLFGNFTAQLRFISDFSISY---EGFNIT------- 1037

Query: 2004 LADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNA 2063
                 +S  D +     CD+P +   +     H   GD   + C  GY L   ++L C  
Sbjct: 1038 -----FSEYDLE----PCDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLG 1088

Query: 2064 QGK--WVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTS 2121
             G+  W  P    +PRC+A              E  +  K   G+++S      +  N  
Sbjct: 1089 GGRRVWSAP----LPRCVA--------------ECGASVKGNEGTLLSPNFPSNYDNNHE 1130

Query: 2122 A--KIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGS--------NYSFGAMVAYS 2171
               KIE   G   +    S Q      G+   + +G  S S        N   G ++  +
Sbjct: 1131 CIYKIETEAGKGIHLRTRSFQLFE---GDTLKVYDGKDSSSRPLGTFTKNELLGLILNST 1187

Query: 2172 CNKGFYIKGEKKSTCEATGQWSSPIPTCHP-VSCGEPPKVENGFLEHTTGRIFESEVRYQ 2230
             N   ++  E  +    T Q      T    V C +P     G+     G   ++ V Y 
Sbjct: 1188 SN---HLWLEFNTNGSDTDQGFQLTYTSFDLVKCEDPGIPNYGYRIRDEGHFTDTVVLYS 1244

Query: 2231 CNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCG 2265
            CNPGY   GS    C +      + PL     +CG
Sbjct: 1245 CNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAECG 1279



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 68/280 (24%), Positives = 106/280 (37%), Gaps = 65/280 (23%)

Query: 3240 SCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAIC----- 3294
            SC  P  P +G   G  +   ST+ + C+PGY L  +   VC+ N QW+  +  C     
Sbjct: 873  SCLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCG 932

Query: 3295 --------------------KETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGP 3334
                                    C   +E  +GK        G  +++     + LE  
Sbjct: 933  GYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGK--------GVQMIFHT---FHLESS 981

Query: 3335 SE-AHCTENGTWSHPVPLCKPNPCPVPFVIPENAL---LSEKEFYVDQNVSIKCREGFLL 3390
             +    TE+G++S PV   +     +P  I         ++  F  D ++S    EGF +
Sbjct: 982  HDYLLITEDGSFSEPV--ARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISY---EGFNI 1036

Query: 3391 QGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEG 3450
                            T ++ +   C  P     +   G H+  GD +T+SC+ GY LEG
Sbjct: 1037 ----------------TFSEYDLEPCDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEG 1080

Query: 3451 FLRSVCLENG--TWTSP-PICRAVCRFPCQ-NGGICQRPN 3486
              +  CL  G   W++P P C A C    + N G    PN
Sbjct: 1081 ATKLTCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPN 1120



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 60/221 (27%), Positives = 83/221 (37%), Gaps = 41/221 (18%)

Query: 362  CREGYRASGQT--------------------CELVHCPALKPPENGYFIQNTCNNHFNAA 401
            C+ GYR  G +                    C+ V C   + P NG F  N      ++ 
Sbjct: 2460 CKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTGNEFT--LDSK 2517

Query: 402  CGVRCHPGFDLVGS--SIILCLPNGLWS--GSESYCRVRTCPHLRQPKHGHI-----SCS 452
                CH GF L  S  +  +C  +GLWS  G    C+   CP +      H+     S S
Sbjct: 2518 VVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSEHVIWRLVSGS 2577

Query: 453  TREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWD-GPE-PRCVERHCSTFQMPKDVIIS 510
              E  Y    L++C  GY LEG   L CQ N  W+ G E P C    C +   P +    
Sbjct: 2578 LNE--YGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPN---- 2631

Query: 511  PHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
              N       +G     +C  G+ L G   +  C  +G W+
Sbjct: 2632 -GNKIGTLTVYGATAIFTCNTGYTLVG-SHVRECLANGLWS 2670



 Score = 65.5 bits (158), Expect = 9e-10
 Identities = 107/474 (22%), Positives = 182/474 (38%), Gaps = 81/474 (17%)

Query: 1776 YTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGY-QLMGVTKITC-LESG 1833
            YT  G+N     +C  PG P NG   G+ + +G+ V+F C +G+ +  G   ITC L+ G
Sbjct: 690  YTTFGQN-----ECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDG 744

Query: 1834 E--WNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCN------KGYTLA----- 1880
               W+  +P C+A  CG      +G I    +    K +  C        G+++      
Sbjct: 745  NVVWSSTVPRCEA-PCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDR 803

Query: 1881 ----GDKESSCLANSSWSHSPPVCEPVKCSSPE---NINNGKYILSGLTYLSTASYSCDT 1933
                 + ++  + +   S SP + E     +P+   +  N  Y+L      +T +     
Sbjct: 804  FQTEVNYDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLL-----FTTDNSRSSI 858

Query: 1934 GYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGY 1993
            G+ +   S+   + S              C +P    +    G +F  R+TVT++C  GY
Sbjct: 859  GFLIHYESVTLESDS--------------CLDPGIPVNGHRHGGDFGIRSTVTFSCDPGY 904

Query: 1994 TLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDI---AFYYCSDG 2050
            TL+  + + C  + +W+                  HA P       G I   +    S G
Sbjct: 905  TLSDDEPLVCERNHQWN------------------HALPSCDALCGGYIQGKSGTVLSPG 946

Query: 2051 YSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSIL-ESVSKAKFAA---GS 2106
            +     + L C    +    +G  M   I H      S  Y ++ E  S ++  A   GS
Sbjct: 947  FPDFYPNSLNCTWTIEVSHGKGVQM---IFHTFHLESSHDYLLITEDGSFSEPVARLTGS 1003

Query: 2107 VVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVR---CGEPPSIMNGYASGSNYS 2163
            V+      G   N +A++  +     +    +I         C +P         G ++ 
Sbjct: 1004 VLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLEPCDDPGVPAFSRRIGFHFG 1063

Query: 2164 FGAMVAYSCNKGFYIKGEKKSTCEATGQ--WSSPIPTCHPVSCGEPPKVENGFL 2215
             G  + +SC  G+ ++G  K TC   G+  WS+P+P C    CG   K   G L
Sbjct: 1064 VGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRC-VAECGASVKGNEGTL 1116



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 217/1035 (20%), Positives = 345/1035 (33%), Gaps = 224/1035 (21%)

Query: 2345 VTFSCKEGHV-LQGPSVLKCLPSQQ---WNDSFPVCKIVLCTPPPLISFGVPIP------ 2394
            V+F C +G V  QG   + C+       W+ + P C+   C      S GV +P      
Sbjct: 720  VSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAP-CGGHLTASSGVILPPGWPGY 778

Query: 2395 -SSALHF--------GSTVKYSCVGGFFLRGNSTTLCQPDG-TWSSPLPECVPVECPQPE 2444
               +LH         G ++K +    F    N  TL   DG   SSPL     +      
Sbjct: 779  YKDSLHCEWIIEAKPGHSIKIT-FDRFQTEVNYDTLEVRDGPASSSPL-----IGEYHGT 832

Query: 2445 EIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEI 2504
            + P  +I      YL   L+T         N+ +  G   H+     T ++  CL P   
Sbjct: 833  QAPQFLISTGNFMYL---LFT-------TDNSRSSIGFLIHY--ESVTLESDSCLDPGIP 880

Query: 2505 LNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNA-----IHCDSP 2559
            +NG     D     TVT+SC+ G+ L     L C     W+   PSC+A     I   S 
Sbjct: 881  VNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCGGYIQGKSG 940

Query: 2560 QPIENGFVE------------GADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPT 2607
              +  GF +               +  G  +I+  F     + H      E G S S P 
Sbjct: 941  TVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTF--HLESSHDYLLITEDG-SFSEPV 997

Query: 2608 CMPIDCGLPPHID---FGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENT 2664
                   LP  I    FG+ T     Q  F  +  +    +      Y L    +  ++ 
Sbjct: 998  ARLTGSVLPHTIKAGLFGNFTA----QLRFISDFSISYEGFNITFSEYDL----EPCDDP 1049

Query: 2665 KESPATHSSNFLYGTMVSYT--CNPGYELLGNPVLICQEDG--TWNGSAPSCISIECDL- 2719
                 +    F +G   S T  C  GY L G   L C   G   W+   P C++ EC   
Sbjct: 1050 GVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVA-ECGAS 1108

Query: 2720 ----------PTAPEN-----GFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWS 2764
                      P  P N       +   ET  G  +    +   +  G  L+  + + K S
Sbjct: 1109 VKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTLK--VYDGKDS 1166

Query: 2765 GASPRCEAISCKKPNPVMNGSIKGSNYTYL--STLYYECDPGYVLNGTERRTCQDDKNWD 2822
             + P       +    ++N +   SN+ +L  +T   + D G+ L  T         ++D
Sbjct: 1167 SSRPLGTFTKNELLGLILNST---SNHLWLEFNTNGSDTDQGFQLTYT---------SFD 1214

Query: 2823 EDEPICIPVDCSSPPVSANG-QVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGS--W 2879
                    V C  P +   G ++R + +     + Y+CN G+ + G+ +  CL+     W
Sbjct: 1215 -------LVKCEDPGIPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVW 1267

Query: 2880 SGATPDCVPVRCATPPQLANGVTEG--LDYGFMKEVTFHCHEGYILHGAPKLTCQS---- 2933
                P C+   C       +  T G  L  G+      + H  +I+   P  T       
Sbjct: 1268 DKPLPSCI-AECGGQ---IHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIV 1323

Query: 2934 -------------DGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYK 2980
                         DG  D++I L +      PED+ H   N  +      +Q+       
Sbjct: 1324 FDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDI-HSTFNSLT------LQF------- 1369

Query: 2981 LHGNSSRRCLSNGSWSGSSPSCLPCRCSTP-VIEYGTVNGTDFDCGKAARIQCFKGFKLL 3039
                 S   +S   +S    + +   C+ P + + GT  G   + G     QC  G++L 
Sbjct: 1370 ----DSDFFISKSGFSIQFSTSIAATCNDPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQ 1425

Query: 3040 GLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGS 3099
            G ++ITC                       + N F      W+ +  T     G  + G 
Sbjct: 1426 GQAKITC---------------------VQLNNRFF-----WQPDPPTCIAACGGNLTGP 1459

Query: 3100 SDLICTEKGVWSQPYP---VCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDT 3156
            + +I +    + QPYP    C+     +P  V   +      ++  E     L  Y  + 
Sbjct: 1460 AGVILSPN--YPQPYPPGKECDWRVKVNPDFVIALI----FKSFNMEPSYDFLHIYEGED 1513

Query: 3157 DTDTFTCQKDGRWFPERISCS--------------------------PKK-CPLPENITH 3189
                      G   PERI  S                          P++ C  P NI +
Sbjct: 1514 SNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDPGNIMN 1573

Query: 3190 ILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSD--ESCSPVSCGKPESP 3247
                G DF +   ++  C  GY     +   C +    +P +     SC+   CG   + 
Sbjct: 1574 GTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCN-APCGGQYTG 1632

Query: 3248 EHGFVVGSKYTFEST 3262
              G V+   Y    T
Sbjct: 1633 SEGVVLSPNYPHNYT 1647



 Score = 61.2 bits (147), Expect = 2e-08
 Identities = 102/446 (22%), Positives = 152/446 (34%), Gaps = 91/446 (20%)

Query: 1686 ERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLD 1745
            E+  CG P     G  +   F  G T+T++C   + L+G+  + C  N  W+G  PSC  
Sbjct: 524  EKGGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC-- 581

Query: 1746 VDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIY 1805
            V  C      S         G  +    P   G+  NC   I    PG+    H     +
Sbjct: 582  VFSCFFNFTAS--------SGIILSPNYPEEYGNNMNCVWLI-ISEPGS--RIHLIFNDF 630

Query: 1806 TVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVS------------------- 1846
             V  +  F   +     G++ IT L +   N  +P   A S                   
Sbjct: 631  DVEPQFDFLAVKD---DGISDITVLGTFSGNE-VPSQLASSGHIVRLEFQSDHSTTGRGF 686

Query: 1847 -----------CGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKES-SCL---ANS 1891
                       C  P IP NG      F  GS V++ C+ G+      ES +C+    N 
Sbjct: 687  NITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNV 746

Query: 1892 SWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCD------TGYSLQ---GPSI 1942
             WS + P CE   C      ++G  +  G       S  C+       G+S++       
Sbjct: 747  VWSSTVPRCE-APCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQ 805

Query: 1943 IECTASGIWDRAPPACHLVFCGE---PPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLD 1999
             E     +  R  PA      GE     A +  + TGN      T   +      L   +
Sbjct: 806  TEVNYDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYE 865

Query: 2000 TIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAF-----YYCSDGYSLA 2054
            ++   +D             SC +P I     P   HR  GD        + C  GY+L+
Sbjct: 866  SVTLESD-------------SCLDPGI-----PVNGHRHGGDFGIRSTVTFSCDPGYTLS 907

Query: 2055 DNSQLLCNAQGKWVPPEGQDMPRCIA 2080
            D+  L+C    +W       +P C A
Sbjct: 908  DDEPLVCERNHQW----NHALPSCDA 929



 Score = 59.7 bits (143), Expect = 5e-08
 Identities = 58/233 (24%), Positives = 80/233 (34%), Gaps = 63/233 (27%)

Query: 1789 CKAPGNPENGHSSGEIYT-VGAEVTFSCQEGYQLMGVTKITCLESGE----WNHLIPYCK 1843
            C  PG PENG  +G  ++ VGA V FSC++ Y L G   ITC    E    W+   P C+
Sbjct: 349  CPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR 408

Query: 1844 AVSCGKPAIPENG----------------CIEELAFTFGSKV------TYRCNKGYTL-- 1879
            A +CG      +G                C+  +  T   KV       +   +GY    
Sbjct: 409  ARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLT 468

Query: 1880 ------AGDKES--------------SCLANSSWSH--------SP------PVCEPVKC 1905
                   GD  S                ++N  W H        SP         E   C
Sbjct: 469  VGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGC 528

Query: 1906 SSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPAC 1958
              P     GK   S   +  T ++ C   + L G  +I C  +  W    P+C
Sbjct: 529  GDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC 581



 Score = 59.3 bits (142), Expect = 7e-08
 Identities = 60/264 (22%), Positives = 91/264 (34%), Gaps = 85/264 (32%)

Query: 361  VCREGYRASGQ------TCELVHCPALKPPENGYFIQNTCNN---------HFNAACGVR 405
            V R   R++GQ      TC +V+C       +  F++N   +          +  +    
Sbjct: 2774 VSRAQCRSNGQWSSPLPTCRVVNC------SDPGFVENAIRHGQQNFPESFEYGMSILYH 2827

Query: 406  CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHG-------------HISCS 452
            C  GF L+GSS + C+ NGLW  S   C   +C H   P +              H SC 
Sbjct: 2828 CKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCR 2887

Query: 453  TREML--------------------------------------------YKTTCLV--AC 466
              E L                                            +KT  L+  +C
Sbjct: 2888 GSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSC 2947

Query: 467  DEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICY 526
            + G++L GS + TC  N  W G +P C    C     P + +I           F +   
Sbjct: 2948 EMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMI----VSSDGILFSSSVI 3003

Query: 527  VSCRQGFILSGVKEMLRCTTSGKW 550
             +C +G+  SG+     CT +G W
Sbjct: 3004 YACWEGYKTSGLMTR-HCTANGTW 3026



 Score = 55.5 bits (132), Expect = 1e-06
 Identities = 62/275 (22%), Positives = 101/275 (36%), Gaps = 46/275 (16%)

Query: 2146 CGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEAT----GQWSSPIPTCHP 2201
            CG P  I+ G   G+ ++ G  + YSC  G+ ++G    TC  +      W  P P C  
Sbjct: 145  CGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRA 204

Query: 2202 V-SCGEPPKVENGFLEHTTGRI----FESEVRYQCNPGYKSVGSP-VFVCQANRHWHSES 2255
              +CG       G L  T+  I    F SE     +  +  +  P   +      +  E 
Sbjct: 205  EGACG-------GTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEE 257

Query: 2256 PLMCVPLDCGKPPPIQNGFMKGENFEVGSK----VQFFCNEGYELVGDSSWTCQKSGKWN 2311
                + +   + P I    M   +  + SK    + F  +  +   G ++    K     
Sbjct: 258  GYDFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIEL 317

Query: 2312 KKSNPKCMPAK--------------------CPEPPLLENQLVLKELTTEVGV-VTFSCK 2350
            K    K +P+K                    CP+P + EN        + VG  V FSC+
Sbjct: 318  KSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCE 377

Query: 2351 EGHVLQGPSVLKCLPSQQ----WNDSFPVCKIVLC 2381
            + +VLQG   + C    +    W+D  P+C+   C
Sbjct: 378  DNYVLQGSKSITCQRVTETLAAWSDHRPICRARTC 412



 Score = 53.9 bits (128), Expect = 3e-06
 Identities = 99/455 (21%), Positives = 160/455 (35%), Gaps = 112/455 (24%)

Query: 2080 AHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECM----RGGQWN-P 2134
            +H C  P  +   +L      +F  G  + + C+ G++L   A + C+     G  W+ P
Sbjct: 142  SHTCGNPGEILKGVLHGT---RFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFP 198

Query: 2135 SPMSIQCIPVRCG----------EPPSIMNGYASGSNYSF------GAMVA-----YSCN 2173
            +P         CG            P   + Y + ++ ++      G  +A     +   
Sbjct: 199  APFCRA--EGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLE 256

Query: 2174 KGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTG------RIFESEV 2227
            +G+     + S  EA   W + +    PV   +     N    H T       + F ++ 
Sbjct: 257  EGYDFL--EISGTEAPSIWLTGMNLPSPVISSK-----NWLRLHFTSDSNHRRKGFNAQF 309

Query: 2228 RYQCNPGYKSVGSPVFVCQANRHWHS---ESPLMCVPLDCGKPPPIQNGFMKGENFE-VG 2283
            + +     KS G  +   +   H +S   +  +  V   C  P   +NG   G +F  VG
Sbjct: 310  QVKKAIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVG 369

Query: 2284 SKVQFFCNEGYELVGDSSWTCQKSGK----WNKKSNPKCMPAKC-------------PEP 2326
            + VQF C + Y L G  S TCQ+  +    W+    P C    C             P  
Sbjct: 370  ANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDH-RPICRARTCGSNLRGPSGVITSPNY 428

Query: 2327 PLLEN------------------QLVLKELTTEVGVVTFSCKEG----------HVLQG- 2357
            P+                     +L  +E   E G  T +  +           +VL G 
Sbjct: 429  PVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGS 488

Query: 2358 --PSVLKCLPSQQW-----NDSF--PVCKIVL-------CTPPPLISFGVPIPSSALHFG 2401
              P ++  + +Q W     +DS   P  K V        C  P + ++G    SS LH G
Sbjct: 489  SVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSFLH-G 547

Query: 2402 STVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECV 2436
             T+ + C   F L G     CQ +  WS   P CV
Sbjct: 548  DTLTFECPAAFELVGERVITCQQNNQWSGNKPSCV 582



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 185/905 (20%), Positives = 279/905 (30%), Gaps = 215/905 (23%)

Query: 1689 SCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCT----DNGSWNGVSPSCL 1744
            +CG P  +  G      F  G  + Y C  GY L G + + C     +  SW+  +P C 
Sbjct: 144  TCGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCR 203

Query: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEI 1804
                C            L    S I S  P +  + +N A+   C      E G +   +
Sbjct: 204  AEGAC---------GGTLRGTSSSISS--PHFPSEYENNAD---CTWTILAEPGDTIALV 249

Query: 1805 YTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFT 1864
            +T      F  +EGY  + +       SG     I +   ++   P I     +  L FT
Sbjct: 250  FT-----DFQLEEGYDFLEI-------SGTEAPSI-WLTGMNLPSPVISSKNWL-RLHFT 295

Query: 1865 FGS--------------KVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPEN 1910
              S              K     ++G  +   K+ S   NS  S          C  P  
Sbjct: 296  SDSNHRRKGFNAQFQVKKAIELKSRGVKMLPSKDGS-HKNSVLSQGGVALVSDMCPDPGI 354

Query: 1911 INNGKYILSGLTYL-STASYSCDTGYSLQGPSIIEC----TASGIWDRAPPACHLVFCGE 1965
              NG+   S  + + +   +SC+  Y LQG   I C         W    P C    CG 
Sbjct: 355  PENGRRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGS 414

Query: 1966 PPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPP 2025
                   VIT  N+  +      C    T    D +  LA  ++       L    D   
Sbjct: 415  NLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFE------LERGYDTLT 468

Query: 2026 IVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQD---MPRCIAHF 2082
            + D      A ++    +  Y   G S+ D    + N    W+  +  D    P   A +
Sbjct: 469  VGD------AGKVGDTRSVLYVLTGSSVPDLIVSMSNQM--WLHLQSDDSIGSPGFKAVY 520

Query: 2083 -------CEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPS 2135
                   C  P   +Y      + + F  G  ++F+C   F L     I C +  QW+ +
Sbjct: 521  QEIEKGGCGDPGIPAYG---KRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGN 577

Query: 2136 PMS----------------------------IQCIPVRCGEPPS----IMNGYASGSNYS 2163
              S                            + C+ +   EP S    I N +     + 
Sbjct: 578  KPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFD 637

Query: 2164 FGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIF 2223
            F A           +K +  S     G +S         S G   ++E      TTGR F
Sbjct: 638  FLA-----------VKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGF 686

Query: 2224 ESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVG 2283
                    N  Y + G                       +C  P    NG   G+ F +G
Sbjct: 687  --------NITYTTFGQN---------------------ECHDPGIPINGRRFGDRFLLG 717

Query: 2284 SKVQFFCNEGY-ELVGDSSWTC--QKSGKWNKKSNPKC---------------MPAKCP- 2324
            S V F C++G+ +  G  S TC  Q        + P+C               +P   P 
Sbjct: 718  SSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPG 777

Query: 2325 -------------EPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWND 2371
                           P    ++      TEV   T   ++G     P + +   +Q    
Sbjct: 778  YYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDGPASSSPLIGEYHGTQ---- 833

Query: 2372 SFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSP 2431
                       P  LIS G       L F +    S + GF +   S TL + D      
Sbjct: 834  ----------APQFLISTG---NFMYLLFTTDNSRSSI-GFLIHYESVTL-ESD------ 872

Query: 2432 LPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKP 2491
                    C  P    NG          ST  ++C PG+ L  +   +C  N  W    P
Sbjct: 873  -------SCLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALP 925

Query: 2492 TCKAI 2496
            +C A+
Sbjct: 926  SCDAL 930



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 106/486 (21%), Positives = 167/486 (34%), Gaps = 91/486 (18%)

Query: 3063 SCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEK----GVWSQPYPVCE 3118
            +CG+   I    +  T     + I YSC  GY+++G + L C         W  P P C 
Sbjct: 144  TCGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCR 203

Query: 3119 PL-SCGSPPSVANAVATGEAHTYESEVKLRC---LEGYTMDTDTDTFTC--QKDGRWFPE 3172
               +CG      ++  +      E E    C   +     DT    FT    ++G  F E
Sbjct: 204  AEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFLE 263

Query: 3173 -------RISCSPKKCPLP----ENITHILVHGDDF----SVNRQVSVSCAEGYTFEGVN 3217
                    I  +    P P    +N   +    D        N Q  V  A      GV 
Sbjct: 264  ISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKSRGVK 323

Query: 3218 ISVCQLDGTWEPPFSDESCSPVS--CGKPESPEHGFVVGSKYT-FESTIIYQCEPGYELE 3274
            +   +         S    + VS  C  P  PE+G   GS ++   + + + CE  Y L+
Sbjct: 324  MLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQ 383

Query: 3275 GNRERVCQENRQ----WSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYS 3330
            G++   CQ   +    WS    IC+   C + L   +G        T PN        Y 
Sbjct: 384  GSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGV------ITSPN--------YP 429

Query: 3331 LEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQ-----NVSIKCR 3385
            ++    AHC    T + P  + K               L+ +EF +++      V    +
Sbjct: 430  VQYEDNAHCVWVITTTDPDKVIK---------------LAFEEFELERGYDTLTVGDAGK 474

Query: 3386 EG------FLLQGHGI---ITCNPDETWTQTSA--------------KCEKISCGPPAHV 3422
             G      ++L G  +   I    ++ W    +              + EK  CG P   
Sbjct: 475  VGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIP 534

Query: 3423 ENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWT-SPPICRAVCRFP-CQNGG 3480
                  G  + +GD +T+ C + + L G     C +N  W+ + P C   C F    + G
Sbjct: 535  AYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSG 594

Query: 3481 ICQRPN 3486
            I   PN
Sbjct: 595  IILSPN 600



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 54/251 (21%), Positives = 93/251 (37%), Gaps = 43/251 (17%)

Query: 2146 CGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCG 2205
            C +P   +NG+  G ++   + V +SC+ G+ +  ++   CE   QW+  +P+C  + CG
Sbjct: 874  CLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDAL-CG 932

Query: 2206 EPPKVENGFLEHTTGRIFESEVRYQCNPGYK---------------SVGSPVFVCQANRH 2250
                   G+++  +G +         +PG+                S G  V +     H
Sbjct: 933  -------GYIQGKSGTVL--------SPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFH 977

Query: 2251 WHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKW 2310
              S    + +  D     P+    + G       K   F N   +L   S ++    G  
Sbjct: 978  LESSHDYLLITEDGSFSEPVAR--LTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFN 1035

Query: 2311 NKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGV---VTFSCKEGHVLQGPSVLKCLPS- 2366
               S     P   P  P        + +    GV   +TFSC  G+ L+G + L CL   
Sbjct: 1036 ITFSEYDLEPCDDPGVPAFS-----RRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGG 1090

Query: 2367 -QQWNDSFPVC 2376
             + W+   P C
Sbjct: 1091 RRVWSAPLPRC 1101



 Score = 42.4 bits (98), Expect = 0.008
 Identities = 20/50 (40%), Positives = 30/50 (60%), Gaps = 2/50 (4%)

Query: 465  ACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCVERHCSTFQMPKDVIISPH 512
            +C  GYRLEG+ KLTC G  +  W  P PRCV    ++ +  +  ++SP+
Sbjct: 1071 SCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPN 1120



 Score = 41.6 bits (96), Expect = 0.014
 Identities = 19/56 (33%), Positives = 27/56 (48%)

Query: 457 LYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPH 512
           L+  T    C   + L G   +TCQ N+QW G +P CV      F     +I+SP+
Sbjct: 545 LHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILSPN 600



 Score = 41.2 bits (95), Expect = 0.019
 Identities = 18/58 (31%), Positives = 32/58 (55%), Gaps = 2/58 (3%)

Query: 363  REGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILC 420
            R+G++ + Q  EL +CP   P +NGY I +  +     +    C+PG+ L+G  ++ C
Sbjct: 2073 RQGFKLAYQAYELQNCPDPPPFQNGYMINS--DYSVGQSVSFECYPGYILIGHPVLTC 2128



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 26/79 (32%), Positives = 37/79 (46%), Gaps = 5/79 (6%)

Query: 437  TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC-QGNSQ--WDGPEPRC 493
            TC     P++G     +RE     T    CD GY+L+G  K+TC Q N++  W    P C
Sbjct: 1391 TCNDPGMPQNGTRYGDSREA--GDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTC 1448

Query: 494  VERHCSTFQMPKDVIISPH 512
            +         P  VI+SP+
Sbjct: 1449 IAACGGNLTGPAGVILSPN 1467



 Score = 36.2 bits (82), Expect = 0.60
 Identities = 16/53 (30%), Positives = 24/53 (45%)

Query: 459 KTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
           ++T   +CD GY L   + L C+ N QW+   P C        Q     ++SP
Sbjct: 893 RSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCGGYIQGKSGTVLSP 945



 Score = 36.2 bits (82), Expect = 0.60
 Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 2/37 (5%)

Query: 460  TTCLVACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCV 494
            T  L +C+ GY + GS+ LTC    +  WD P P C+
Sbjct: 1239 TVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCI 1275



 Score = 35.8 bits (81), Expect = 0.78
 Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 5/53 (9%)

Query: 465 ACDEGYRLEGSDKLTCQGNSQ----WDGPEPRCVERHC-STFQMPKDVIISPH 512
           +C++ Y L+GS  +TCQ  ++    W    P C  R C S  + P  VI SP+
Sbjct: 375 SCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPN 427



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 19/70 (27%), Positives = 30/70 (42%), Gaps = 2/70 (2%)

Query: 466  CDEGYRLEGSDKLTCQGNS--QWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGT 523
            C+ GY L+G   ++C   +  +W+ P P C+     T      VI+SP   G  P     
Sbjct: 1942 CEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATCGGTLSTLGGVILSPGFPGSYPNNLDC 2001

Query: 524  ICYVSCRQGF 533
               +S   G+
Sbjct: 2002 TWRISLPIGY 2011



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 23/78 (29%), Positives = 34/78 (43%), Gaps = 6/78 (7%)

Query: 438  CPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQ----GNSQWDGPEPRC 493
            C  + +P++G    S  E    +     C+ GY L+GS  L CQ      +QW+   P C
Sbjct: 1742 CSSVPEPRYGRRIGS--EFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799

Query: 494  VERHCSTFQMPKDVIISP 511
            V      F   +  I+SP
Sbjct: 1800 VVPCSGNFTQRRGTILSP 1817



 Score = 32.3 bits (72), Expect = 8.6
 Identities = 12/28 (42%), Positives = 16/28 (57%)

Query: 406 CHPGFDLVGSSIILCLPNGLWSGSESYC 433
           C   F+LVG  +I C  N  WSG++  C
Sbjct: 554 CPAAFELVGERVITCQQNNQWSGNKPSC 581


>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
            sapiens]
          Length = 3538

 Score =  474 bits (1219), Expect = e-133
 Identities = 279/831 (33%), Positives = 389/831 (46%), Gaps = 47/831 (5%)

Query: 2381 CTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDG----TWSSPLPECV 2436
            C+ P     G  I  +     S V+++C  GF L G S+ +C+        W +P+P C 
Sbjct: 2465 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2524

Query: 2437 PVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGN--TTTLCGENGHWLGGK--PT 2492
             + C  P+   NG I        +   Y C  G+ L     TT +C  +G W      P 
Sbjct: 2525 AISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPR 2584

Query: 2493 CKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCN 2552
            C  I C +     NG    T   YG T  ++C+ GF L G +   CL +G W      C 
Sbjct: 2585 CVVISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCL 2644

Query: 2553 AIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEES-GWSSSIPTCMPI 2611
            A HC  P+ I NG V G +Y Y   ++Y C PGF++ G +++ C++   WS  +P+C+P+
Sbjct: 2645 AGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV 2704

Query: 2612 DCGLPPH----------IDFGDCTKLKDDQGYFEQEDD--MMEVPYVTPHPPYHLGAVAK 2659
             CG P             +F D      + GY  Q       +      HPP     V  
Sbjct: 2705 SCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNC 2764

Query: 2660 TWE----NTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISI 2715
            +      N+K        NF YGT+V Y CNPGY L G+ VLICQ +G W+   P CI I
Sbjct: 2765 SDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMI 2824

Query: 2716 ECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAI-- 2773
            +C  P  P N  L   + + GS V YSC     L G   R C  N  WSG+ P C     
Sbjct: 2825 DCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDAT 2884

Query: 2774 -SCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVD 2832
             +C  P    +GS + SN+   ST+ Y CD GY+L+G+E RTC  + +W   +P C  V 
Sbjct: 2885 GTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQ 2944

Query: 2833 CSSPPVSANGQV-RGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRC 2891
            C +P  +ANG+V R D  TF   + Y+C EG++L G   R C ANG+WSG  P+C  + C
Sbjct: 2945 CGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISC 3004

Query: 2892 ATPPQLANGVTEGLDYGFMKEVTFHCHEGYI--LHGAPKLTCQSDGNWDAEIPLCKPVNC 2949
              P   ANG+  G DY   + V++ C  GY   L+G+   TC  +G W   +P C+ V C
Sbjct: 3005 GDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTC 3064

Query: 2950 GPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCST 3009
              P  +++G   G +F  G  I Y C PGY+L   +   C+ NG+WSG  P CLP  C  
Sbjct: 3065 PTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGD 3124

Query: 3010 PVI-EYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHC---EHTSCG 3065
            P I   G   G  F         C   F L+G S   C+ADG WS   PHC     TSC 
Sbjct: 3125 PGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCE 3184

Query: 3066 SLPMIP------NAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEP 3119
            + P +P      N F  +  S    V+ + C+ G+++QGS+   C     WS   P C P
Sbjct: 3185 N-PGVPRHGSQNNTFGFQVGS----VVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIP 3239

Query: 3120 LSCGSPPSVANAVATG-EAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRW 3169
             SC  P + A+A   G +  ++   +   C  G+ +   T+   C+ D  W
Sbjct: 3240 HSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTW 3290



 Score =  445 bits (1145), Expect = e-124
 Identities = 308/1099 (28%), Positives = 460/1099 (41%), Gaps = 140/1099 (12%)

Query: 2372 SFPVCKIVLCTPPPLISFGVPIPSSAL-------HFGSTVKYSCVGGFFLRGNSTTLC-- 2422
            S+   ++ +C PPP      P+P++ +         G  ++Y C+ GF L GN+   C  
Sbjct: 2282 SYHAYQLRVCQPPP------PVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRL 2335

Query: 2423 ----QPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTT 2478
                Q DG      P    V CP  E              L +      PG+        
Sbjct: 2336 GERLQMDGA-----PPVCQVLCPANE------------LRLDSTGVILSPGYPDSYPNLQ 2378

Query: 2479 LCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTC 2538
            +C  +     G      +E  + ++    +F    ++ G  +          +  SA   
Sbjct: 2379 MCAWSISVEKGYNITMFVEFFQTEK----EFDVLQVYDGPNIQSPVLISLSGDYSSAFNI 2434

Query: 2539 LETG-----DWDVDAPSCN--------AIHCDSPQPIENGFV-EGADYSYGAIIIYSCFP 2584
               G      W  D  +          A +C +P+   +G++         +++ ++C  
Sbjct: 2435 TSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDR 2494

Query: 2585 GFQVAGHAMQTCEESG-----WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDD 2639
            GF++ G +   C +S      W + +P C  I CG+P                       
Sbjct: 2495 GFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPK---------------------- 2532

Query: 2640 MMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVL-- 2697
                       P + G +              ++++L GT V+Y CN GY L    +   
Sbjct: 2533 ----------APTNGGIL--------------TTDYLVGTRVTYFCNDGYRLSSKELTTA 2568

Query: 2698 ICQEDGTWNG--SAPSCISIEC-DLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDL 2754
            +CQ DGTW+     P C+ I C +LPT P NG    T+TS GS   ++C  G +L GS +
Sbjct: 2569 VCQSDGTWSNHNKTPRCVVISCGELPTPP-NGNKIGTQTSYGSTAIFTCDLGFMLVGSAV 2627

Query: 2755 RLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRT 2814
            R CL +  WS +  RC A  C  P  ++NG + G NY Y  T+ Y+C+PG+ L G+  R 
Sbjct: 2628 RECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRI 2687

Query: 2815 CQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCL 2874
            CQ D NW    P C+PV C  P     G+  G+ + F   + ++CN G+L++G     C 
Sbjct: 2688 CQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQ 2747

Query: 2875 ANGSWSGATPDCVPVRCATPPQLANGVTEG-LDYG---FMKEVTFHCHEGYILHGAPKLT 2930
            AN  WS   P C  V C+ P   AN   E  +++G   +   V + C+ GY L G+  L 
Sbjct: 2748 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLI 2807

Query: 2931 CQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCL 2990
            CQ +G WD  +P C  ++CG P    +   +G  +  G  + Y C     L G SSR C 
Sbjct: 2808 CQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQ 2867

Query: 2991 SNGSWSGSSPSC---LPCRCSTP-VIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITC 3046
             NG WSGS P C       C  P    +G+   ++F      R  C  G+ L G  E TC
Sbjct: 2868 LNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTC 2927

Query: 3047 EADGQWSSGFPHCEHTSCGSLPMIPN--AFISETSSWKENVITYSCRSGYVIQGSSDLIC 3104
             A+G W+   P C+   CG+     N   F  + +++  +VI YSC  GY++ G S   C
Sbjct: 2928 LANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVI-YSCMEGYILSGPSVRQC 2986

Query: 3105 TEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTF-TC 3163
            T  G WS   P C  +SCG P   AN +  G+ +     V   C  GYTM+ +     TC
Sbjct: 2987 TANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTC 3046

Query: 3164 QKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQL 3223
              +G W     +C    CP P  I++  + G +F     +S  C+ GY      +  C  
Sbjct: 3047 TINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVG 3106

Query: 3224 DGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQE 3283
            +GTW        C P  CG P  P  G   G  + ++S + + C   + L G+  R+CQ 
Sbjct: 3107 NGTWSGEV--PQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQA 3164

Query: 3284 NRQWSGGVAICKE---TRCETPLEFLNGKADIENRT----TGPNVVYSCNRGYSLEGPSE 3336
            +  WSG    C E   T CE P    +G    +N T     G  V + C +G+ L+G + 
Sbjct: 3165 DGTWSGSSPHCIEPTQTSCENPGVPRHGS---QNNTFGFQVGSVVQFHCKKGHLLQGSTT 3221

Query: 3337 AHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQG---H 3393
              C  + TWS   P C P+ C  P       ++          +   C+ GF L G   H
Sbjct: 3222 RTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEH 3281

Query: 3394 GIITCNPDETWTQTSAKCE 3412
             +  C  D TWT     CE
Sbjct: 3282 RV--CRSDNTWTGKVPICE 3298



 Score =  444 bits (1141), Expect = e-123
 Identities = 265/822 (32%), Positives = 384/822 (46%), Gaps = 38/822 (4%)

Query: 2679 TMVSYTCNPGYELLGNPVLICQEDG----TWNGSAPSCISIECDLPTAPENGFLRFTETS 2734
            ++V + C+ G+ L+G    +C++       W+   P+C +I C +P AP NG +  T+  
Sbjct: 2486 SVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYL 2545

Query: 2735 MGSAVQYSCKPGHILAGSDLR--LCLENRKWSG--ASPRCEAISCKKPNPVMNGSIKGSN 2790
            +G+ V Y C  G+ L+  +L   +C  +  WS    +PRC  ISC +     NG+  G+ 
Sbjct: 2546 VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGNKIGTQ 2605

Query: 2791 YTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYT 2850
             +Y ST  + CD G++L G+  R C     W E E  C+   C  P +  NGQV G+ Y 
Sbjct: 2606 TSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYG 2665

Query: 2851 FQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFM 2910
            ++  + Y CN GF L G+  R+C  + +WSG  P CVPV C  P     G T G  + F 
Sbjct: 2666 YRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFN 2725

Query: 2911 KEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPP---------EDLAHGFPN 2961
              VTF C+ GY++ G  K  CQ++  W    P+CK VNC  P           + HG   
Sbjct: 2726 DVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHG--- 2782

Query: 2962 GFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTV-NGT 3020
              +F +G  + Y C PGY L G+S   C  NG W    P C+   C  P +    V +G 
Sbjct: 2783 --NFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGE 2840

Query: 3021 DFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSL--PMIPNAFISET 3078
             +  G      C     LLG S  TC+ +G WS   PHC   + G+   P  P     + 
Sbjct: 2841 KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQE 2900

Query: 3079 SSWK-ENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANA-VATGE 3136
            S+++ ++ + Y+C +GY++ GS +  C   G W+   P C+ + CG+P + AN  V   +
Sbjct: 2901 SNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRID 2960

Query: 3137 AHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDD 3196
              T+ S V   C+EGY + +      C  +G W     +C+   C  P    + L +GDD
Sbjct: 2961 GTTFSSSVIYSCMEGYIL-SGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDD 3019

Query: 3197 FSVNRQVSVSCAEGYTFE--GVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVG 3254
            + V + VS  C  GYT E  G  I  C ++GTW       +C  V+C  P    +G + G
Sbjct: 3020 YVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMP--TCRAVTCPTPPQISNGRLEG 3077

Query: 3255 SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIEN 3314
            + + +  +I Y C PGYEL       C  N  WSG V  C    C  P     GK + ++
Sbjct: 3078 TNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKS 3137

Query: 3315 RTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLC---KPNPCPVPFVIPENALLSE 3371
                  V +SCN  + L G S   C  +GTWS   P C       C  P V    +  + 
Sbjct: 3138 FIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNT 3197

Query: 3372 KEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVH 3431
              F V   V   C++G LLQG    TC PD TW+    +C   SC  P    +A   G+ 
Sbjct: 3198 FGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMD 3257

Query: 3432 Y-QYGDMITYSCYSGYMLEGFL-RSVCLENGTWTSP-PICRA 3470
               +G  + Y+C  G+ L G     VC  + TWT   PIC A
Sbjct: 3258 LPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEA 3299



 Score =  416 bits (1068), Expect = e-115
 Identities = 267/841 (31%), Positives = 384/841 (45%), Gaps = 65/841 (7%)

Query: 1652 SKVNLFCDPGFQLVGNPVQYCLNQGQ----WTQPLPHCERISCGVPPPLENGFHSADDFY 1707
            S V   CD GF+LVG     C         W  P+P C+ ISCG+P    NG     D+ 
Sbjct: 2486 SVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYL 2545

Query: 1708 AGSTVTYQCNNGYYLLGD--SRMFCTDNGSW--NGVSPSCLDVDECA----------VGS 1753
             G+ VTY CN+GY L     +   C  +G+W  +  +P C+ V  C           +G+
Sbjct: 2546 VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCV-VISCGELPTPPNGNKIGT 2604

Query: 1754 DCSEHASCL---NVDGSYICSCVPPYTGDGKNCAEPIKCKAP--GNPE---NGHSSGEIY 1805
              S  ++ +   ++    + S V      G       +C A   G PE   NG   GE Y
Sbjct: 2605 QTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENY 2664

Query: 1806 TVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTF 1865
                 V + C  G++L+G +   C +   W+  +P C  VSCG P  P  G      F F
Sbjct: 2665 GYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNF 2724

Query: 1866 GSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSP----ENINNGKYILSGL 1921
               VT+ CN GY + G  ++ C AN  WSH PP+C+ V CS P     +    K      
Sbjct: 2725 NDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNF 2784

Query: 1922 TYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTF 1981
            TY +   Y C+ GY L G S++ C  +G WD+  P C ++ CG P    +AV++G  +TF
Sbjct: 2785 TYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTF 2844

Query: 1982 RNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQC---LAVSCDEPPIVDHASPETAHRL 2038
             +TV Y+C    +L G  +  C  +G WS S   C      +C +P    H S + ++  
Sbjct: 2845 GSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFR 2904

Query: 2039 FGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVS 2098
                  Y C  GY L  + +  C A G W   +    P C A  C  P + +   +  + 
Sbjct: 2905 TKSTVRYACDTGYILHGSEERTCLANGSWTGRQ----PECKAVQCGNPGTTANGKVFRID 2960

Query: 2099 KAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYAS 2158
               F+  S V + CMEG++L+  +  +C   G W  S     C  + CG+P    NG   
Sbjct: 2961 GTTFS--SSVIYSCMEGYILSGPSVRQCTANGTW--SGTLPNCTIISCGDPGIPANGLRY 3016

Query: 2159 GSNYSFGAMVAYSCNKGF--YIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLE 2216
            G +Y  G  V+Y C  G+   + G +  TC   G WS  +PTC  V+C  PP++ NG LE
Sbjct: 3017 GDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLE 3076

Query: 2217 HTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMK 2276
             T    +   + Y C+PGY+     V  C  N  W  E P  C+P  CG P     G  +
Sbjct: 3077 GTNFD-WGFSISYICSPGYELSFPAVLTCVGNGTWSGEVP-QCLPKFCGDPGIPAQGKRE 3134

Query: 2277 GENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCM---PAKCPEPPLLENQL 2333
            G++F   S+V F CN  + LVG S+  CQ  G W+  S+P C+      C  P +  +  
Sbjct: 3135 GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWS-GSSPHCIEPTQTSCENPGVPRHGS 3193

Query: 2334 VLKELTTEVG-VVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLC----TPPPLIS 2388
                   +VG VV F CK+GH+LQG +   CLP   W+   P C    C    TP     
Sbjct: 3194 QNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANV 3253

Query: 2389 FGVPIPSSALHFGSTVKYSCVGGFFLRGNST-TLCQPDGTWSSPLPEC-----VPVECPQ 2442
             G+ +PS     G T+ Y+C  GFFL G +   +C+ D TW+  +P C     + V+ P+
Sbjct: 3254 VGMDLPS----HGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPR 3309

Query: 2443 P 2443
            P
Sbjct: 3310 P 3310



 Score =  415 bits (1067), Expect = e-115
 Identities = 501/2108 (23%), Positives = 767/2108 (36%), Gaps = 337/2108 (15%)

Query: 1659 DPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSADD-FYAGSTVTYQCN 1717
            D GFQLV    +           L HCE    G+P   + G+  +D   +AGST+ Y CN
Sbjct: 1235 DEGFQLVYTSFE-----------LSHCE--DPGIP---QFGYKISDQGHFAGSTIIYGCN 1278

Query: 1718 NGYYLLGDSRMFCT--DNGSWNGVSPSCLDVDECA---VGSDCSEHAS------------ 1760
             GY L G S + C   +  +W+   PSC  + EC     G       S            
Sbjct: 1279 PGYTLHGSSLLKCMTGERRAWDYPLPSC--IAECGGRFKGESSGRILSPGYPFPYDNNLR 1336

Query: 1761 ---CLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQE 1817
                + VD   I S    +       +  I     G PEN     EI   G+ +      
Sbjct: 1337 CMWMIEVDPGNIVSL--QFLAFDTEASHDILRVWDGPPENDMLLKEIS--GSLIPEGIHS 1392

Query: 1818 GYQLMGVTKITCLESGEWNHLIPYCKAVS--CGKPAIPENGCIEELAFTFGSKVTYRCNK 1875
               ++ +   T     +    I +  +V+  C  P +P NG         G  V ++C+ 
Sbjct: 1393 TLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDP 1452

Query: 1876 GYTLAGDKESSCLANSS---WSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCD 1932
            GY L G++  +C+   +   W  SPPVC    C      ++G  +     +    S  CD
Sbjct: 1453 GYELQGEERITCIQVENRYFWQPSPPVCI-APCGGNLTGSSGFILSPNFPHPYPHSRDCD 1511

Query: 1933 TGYSLQGPSIIECTASG-----------IWDRAPPACHLVFCGEPPAIKDAVITGNN--- 1978
               ++    +I                 I+D       L+   +   + + + + +N   
Sbjct: 1512 WTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMH 1571

Query: 1979 --FTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAH 2036
              F    +V+YT   G+ L                  +  L  SC +P  + + +     
Sbjct: 1572 LAFRSDGSVSYT---GFHL----------------EYKAKLRESCFDPGNIMNGTRLGMD 1612

Query: 2037 RLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILES 2096
               G    YYC  GY L   S L C       P   + +P C A    +      ++L  
Sbjct: 1613 YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSP 1672

Query: 2097 VSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGY 2156
                 ++ G           V + +   E +  GQ+     S+  +      P    +  
Sbjct: 1673 NYPKNYSVG--------HNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLL 1724

Query: 2157 ASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWS--SPIPTCHPVSCGEPPKVENGF 2214
            +S S    G  +  S      I+        A G       +P      C   P+   G 
Sbjct: 1725 SSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFG- 1783

Query: 2215 LEHTTGRIFE--SEVRYQCNPGYKSVGSPVFVCQ----ANRHWHSESPLMCVP------- 2261
                 G  F   S V + CNPGY   GS    C+    +   W+   P   VP       
Sbjct: 1784 --RRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTK 1841

Query: 2262 -----LDCGKPPPIQNGFM--------KGENFEVGSKVQFFCNEGYELV-----GDSSWT 2303
                 L  G P P  N           +G   +V   V F     ++ +     GD++  
Sbjct: 1842 RKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQV-QVVSFATEHNWDSLDFYDGGDNN-- 1898

Query: 2304 CQKSGKWNKKSNPKCMPA------------------------------KCPEPPLLENQL 2333
              + G ++  + P  + +                               CPEP    + +
Sbjct: 1899 APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGI 1958

Query: 2334 VLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPS--QQWNDSFPVCKIVLCTPPP------ 2385
             + +      VV+F C +G+ LQG S + C+P   ++WN   P+C +  C          
Sbjct: 1959 KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC-LAQCGGAMSDFSGV 2017

Query: 2386 LISFGVP--IPSSALHFGSTVKYSCVGGF-----FLRGNSTTLCQPDGTWSSPLPECVPV 2438
            ++S G P   PSS      T   +   GF     F+  ++ T+       S        +
Sbjct: 2018 ILSPGFPGNYPSS---LDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVI 2074

Query: 2439 ECPQPEEIPNGIIDV--QGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAI 2496
                  +IP+ +     +   Y  +     K GF +V     L                 
Sbjct: 2075 GRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS--------------- 2119

Query: 2497 ECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLE--TGDWDVDAPSCNAI 2554
             C  P+   NG     D   GQT+++ C  G+ L G SALTCL   + +W+   P C A+
Sbjct: 2120 -CPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL 2178

Query: 2555 HCDSPQPIENGFVEGADYSYGAIIIYSCF------PGF---------------------- 2586
             C       NG +    Y         CF      PG                       
Sbjct: 2179 -CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWD 2237

Query: 2587 -------QVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDD 2639
                   Q+   +  T  ES +S+S    +        H DF          G+F     
Sbjct: 2238 GPDQNSPQIGQFSGNTALESVYSTSNQILIKF------HSDF-------TTSGFFVLSYH 2284

Query: 2640 MMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLIC 2699
              ++    P PP     +            T    F  G ++ Y C PG+ L+GN +L C
Sbjct: 2285 AYQLRVCQPPPPVPNAEIL-----------TEDDEFEIGDIIRYQCLPGFTLVGNAILTC 2333

Query: 2700 Q--EDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLC 2757
            +  E    +G+ P C  + C     P N  LR   T +         PG+  +  +L++C
Sbjct: 2334 RLGERLQMDGAPPVC-QVLC-----PANE-LRLDSTGV------ILSPGYPDSYPNLQMC 2380

Query: 2758 ---LENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTER-- 2812
               +   K    +   E    +K   V+     G N      +    D     N T    
Sbjct: 2381 AWSISVEKGYNITMFVEFFQTEKEFDVLQ-VYDGPNIQSPVLISLSGDYSSAFNITSNGH 2439

Query: 2813 ----RTCQDDKNWDEDEPI-CIPVDCSSPPVSANGQVRGDEY-TFQKEIEYTCNEGFLLE 2866
                +   D  N  +   I  I   CS+P    +G +           + + C+ GF L 
Sbjct: 2440 EVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLV 2499

Query: 2867 GARSRVCLANG----SWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYI 2922
            G  S VC  +     +W    P C  + C  P    NG     DY     VT+ C++GY 
Sbjct: 2500 GKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYR 2559

Query: 2923 LHGAPKLT--CQSDGNWDA--EIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPG 2978
            L      T  CQSDG W    + P C  ++CG      +G   G    +G    + C  G
Sbjct: 2560 LSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGNKIGTQTSYGSTAIFTCDLG 2619

Query: 2979 YKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTP-VIEYGTVNGTDFDCGKAARIQCFKGFK 3037
            + L G++ R CLS+G WS S   CL   C  P +I  G V G ++        QC  GF+
Sbjct: 2620 FMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFR 2679

Query: 3038 LLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKEN-VITYSCRSGYVI 3096
            L+G S   C+ D  WS   P C   SCG  P  P    +  + +  N V+T+SC  GY++
Sbjct: 2680 LIGSSVRICQQDHNWSGQLPSCVPVSCGH-PGSPIYGRTSGNGFNFNDVVTFSCNIGYLM 2738

Query: 3097 QGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAH----TYESEVKLRCLEGY 3152
            QG +   C     WS P P+C+ ++C  P   AN+    +      TY + V   C  GY
Sbjct: 2739 QGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGY 2798

Query: 3153 TMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYT 3212
             +   +    CQ +G+W      C    C  P    + ++ G+ ++    V  SC    +
Sbjct: 2799 FL-FGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRS 2857

Query: 3213 FEGVNISVCQLDGTW---EPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEP 3269
              G +   CQL+G W   +P  S ++    +CG P +P HG    S +  +ST+ Y C+ 
Sbjct: 2858 LLGQSSRTCQLNGHWSGSQPHCSGDATG--TCGDPGTPGHGSRQESNFRTKSTVRYACDT 2915

Query: 3270 GYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKA-DIENRTTGPNVVYSCNRG 3328
            GY L G+ ER C  N  W+G    CK  +C  P    NGK   I+  T   +V+YSC  G
Sbjct: 2916 GYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEG 2975

Query: 3329 YSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGF 3388
            Y L GPS   CT NGTWS  +P C    C  P  IP N L    ++ V QNVS  C+ G+
Sbjct: 2976 YILSGPSVRQCTANGTWSGTLPNCTIISCGDPG-IPANGLRYGDDYVVGQNVSYMCQPGY 3034

Query: 3389 LLQGHG--IITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGY 3446
             ++ +G  I TC  + TW+     C  ++C  P  + N    G ++ +G  I+Y C  GY
Sbjct: 3035 TMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGY 3094

Query: 3447 MLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGI---CQRPNACSCPEGWMGRLCEEPI 3503
             L       C+ NGTW S  + + + +F C + GI    +R       +  +   C  P 
Sbjct: 3095 ELSFPAVLTCVGNGTW-SGEVPQCLPKF-CGDPGIPAQGKREGKSFIYQSEVSFSCNFPF 3152

Query: 3504 CILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRPNRCHCLSSWTGHNC 3563
             ++         +   C     W+GS  H             C+ P +  C +     + 
Sbjct: 3153 ILVGS-------STRICQADGTWSGSSPH-------------CIEPTQTSCENPGVPRHG 3192

Query: 3564 SRKRRTGF 3571
            S+    GF
Sbjct: 3193 SQNNTFGF 3200



 Score =  412 bits (1060), Expect = e-114
 Identities = 261/849 (30%), Positives = 392/849 (46%), Gaps = 45/849 (5%)

Query: 1789 CKAPGNPENGH----SSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESG----EWNHLIP 1840
            C  P +P +G+    + G++ +V   V ++C  G++L+G +   C +S      W+  +P
Sbjct: 2465 CSTPESPPHGYIISQTGGQLNSV---VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVP 2521

Query: 1841 YCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESS--CLANSSWS--HS 1896
             C+A+SCG P  P NG I    +  G++VTY CN GY L+  + ++  C ++ +WS  + 
Sbjct: 2522 ACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNK 2581

Query: 1897 PPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPP 1956
             P C  + C       NG  I +  +Y STA ++CD G+ L G ++ EC +SG+W  +  
Sbjct: 2582 TPRCVVISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESET 2641

Query: 1957 ACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQC 2016
             C    CG P  I +  + G N+ +R+TV Y C  G+ L G     C  D  WS     C
Sbjct: 2642 RCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSC 2701

Query: 2017 LAVSCDEP--PIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQD 2074
            + VSC  P  PI    S    +  F D+  + C+ GY +   ++  C A  +W  P    
Sbjct: 2702 VPVSCGHPGSPIYGRTSGNGFN--FNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPP--- 2756

Query: 2075 MPRCIAHFCEKPPSVSYSILES-VSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWN 2133
             P C    C  P   + S  ES +    F  G+VV + C  G+ L  S+ + C   GQW+
Sbjct: 2757 -PMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWD 2815

Query: 2134 -PSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQW 2192
             P P   +CI + CG P    N   SG  Y+FG+ V YSC     + G+   TC+  G W
Sbjct: 2816 KPLP---ECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHW 2872

Query: 2193 SSPIPTCH---PVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANR 2249
            S   P C      +CG+P    +G  + +  R  +S VRY C+ GY   GS    C AN 
Sbjct: 2873 SGSQPHCSGDATGTCGDPGTPGHGSRQESNFRT-KSTVRYACDTGYILHGSEERTCLANG 2931

Query: 2250 HWHSESPLMCVPLDCGKPPPIQNG-FMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSG 2308
             W    P  C  + CG P    NG   + +     S V + C EGY L G S   C  +G
Sbjct: 2932 SWTGRQP-ECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANG 2990

Query: 2309 KWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHV--LQGPSVLKCLPS 2366
             W+  + P C    C +P +  N L   +       V++ C+ G+   L G  +  C  +
Sbjct: 2991 TWS-GTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN 3049

Query: 2367 QQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDG 2426
              W+   P C+ V C  PP IS G  +  +   +G ++ Y C  G+ L   +   C  +G
Sbjct: 3050 GTWSGVMPTCRAVTCPTPPQISNG-RLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNG 3108

Query: 2427 TWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHW 2486
            TWS  +P+C+P  C  P     G  + +   Y S   ++C   F LVG++T +C  +G W
Sbjct: 3109 TWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTW 3168

Query: 2487 LGGKPTC---KAIECLKPKEILNGKFSYT-DLHYGQTVTYSCNRGFRLEGPSALTCLETG 2542
             G  P C       C  P    +G  + T     G  V + C +G  L+G +  TCL   
Sbjct: 3169 SGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL 3228

Query: 2543 DWDVDAPSCNAIHCDSPQPIENGFVEGADY-SYGAIIIYSCFPGFQVAGHA-MQTC-EES 2599
             W    P C    C  P+   +  V G D  S+G  +IY+C PGF +AG    + C  ++
Sbjct: 3229 TWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN 3288

Query: 2600 GWSSSIPTC 2608
             W+  +P C
Sbjct: 3289 TWTGKVPIC 3297



 Score =  391 bits (1005), Expect = e-108
 Identities = 264/887 (29%), Positives = 373/887 (42%), Gaps = 75/887 (8%)

Query: 1690 CGVPPPLENGFH-SADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNG----SWNGVSPSCL 1744
            C  P    +G+  S       S V + C+ G+ L+G S   C  +     +W+   P+C 
Sbjct: 2465 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC- 2523

Query: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEI 1804
                                                    + I C  P  P NG      
Sbjct: 2524 ----------------------------------------QAISCGIPKAPTNGGILTTD 2543

Query: 1805 YTVGAEVTFSCQEGYQLMG--VTKITCLESGEW-NH-LIPYCKAVSCGKPAIPENGCIEE 1860
            Y VG  VT+ C +GY+L    +T   C   G W NH   P C  +SCG+   P NG    
Sbjct: 2544 YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGNKIG 2603

Query: 1861 LAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSG 1920
               ++GS   + C+ G+ L G     CL++  WS S   C    C  PE I NG+ I   
Sbjct: 2604 TQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGEN 2663

Query: 1921 LTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFT 1980
              Y  T  Y C+ G+ L G S+  C     W    P+C  V CG P +      +GN F 
Sbjct: 2664 YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFN 2723

Query: 1981 FRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPET----AH 2036
            F + VT++C  GY + G    +C A+ +WS     C  V+C +P I  ++  E+     +
Sbjct: 2724 FNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGN 2783

Query: 2037 RLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILES 2096
              +G + FY C+ GY L  +S L+C   G+W  P    +P CI   C  P     ++L  
Sbjct: 2784 FTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKP----LPECIMIDCGHPGVPPNAVL-- 2837

Query: 2097 VSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPS-PMSIQCIPVRCGEPPSIMNG 2155
             S  K+  GS V + C     L   +   C   G W+ S P         CG+P +  +G
Sbjct: 2838 -SGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG 2896

Query: 2156 YASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFL 2215
                SN+   + V Y+C+ G+ + G ++ TC A G W+   P C  V CG P    NG +
Sbjct: 2897 SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKV 2956

Query: 2216 EHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFM 2275
                G  F S V Y C  GY   G  V  C AN  W    P  C  + CG P    NG  
Sbjct: 2957 FRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLP-NCTIISCGDPGIPANGLR 3015

Query: 2276 KGENFEVGSKVQFFCNEGY--ELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQL 2333
             G+++ VG  V + C  GY  EL G    TC  +G W+    P C    CP PP + N  
Sbjct: 3016 YGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVM-PTCRAVTCPTPPQISNGR 3074

Query: 2334 VLKELTTEVGV-VTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVP 2392
             L+    + G  +++ C  G+ L  P+VL C+ +  W+   P C    C  P + + G  
Sbjct: 3075 -LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKR 3133

Query: 2393 IPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECV---PVECPQPEEIPNG 2449
               S + + S V +SC   F L G+ST +CQ DGTWS   P C+      C  P    +G
Sbjct: 3134 EGKSFI-YQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHG 3192

Query: 2450 I-IDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGK 2508
               +  G    S   + CK G  L G+TT  C  +  W G +P C    C +P+   +  
Sbjct: 3193 SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHAN 3252

Query: 2509 FSYTDL-HYGQTVTYSCNRGFRLEGPSA-LTCLETGDWDVDAPSCNA 2553
                DL  +G T+ Y+C  GF L G +    C     W    P C A
Sbjct: 3253 VVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEA 3299



 Score =  330 bits (846), Expect = 2e-89
 Identities = 210/695 (30%), Positives = 297/695 (42%), Gaps = 42/695 (6%)

Query: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAGS 1710
            GS     CD GF LVG+ V+ CL+ G W++    C    CG+P  + NG    +++    
Sbjct: 2609 GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRD 2668

Query: 1711 TVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHAS--CLNVDGSY 1768
            TV YQCN G+ L+G S   C  + +W+G  PSC+ V     GS      S    N +   
Sbjct: 2669 TVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVV 2728

Query: 1769 ICSCVPPYTGDGKNCAE---------------PIKCKAPGNPENGHSSGEI----YTVGA 1809
              SC   Y   G   A+                + C  PG P N     +I    +T G 
Sbjct: 2729 TFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGT 2788

Query: 1810 EVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKV 1869
             V + C  GY L G + + C  +G+W+  +P C  + CG P +P N  +    +TFGS V
Sbjct: 2789 VVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTV 2848

Query: 1870 TYRCNKGYTLAGDKESSCLANSSWSHSPPVCE---PVKCSSPENINNGKYILSGLTYLST 1926
             Y C    +L G    +C  N  WS S P C       C  P    +G    S     ST
Sbjct: 2849 HYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKST 2908

Query: 1927 ASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDA-VITGNNFTFRNTV 1985
              Y+CDTGY L G     C A+G W    P C  V CG P    +  V   +  TF ++V
Sbjct: 2909 VRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSV 2968

Query: 1986 TYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFY 2045
             Y+C EGY L+G    +C A+G WS +   C  +SC +P I  +        + G    Y
Sbjct: 2969 IYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSY 3028

Query: 2046 YCSDGYSLADNSQLL--CNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFA 2103
             C  GY++  N   +  C   G W       MP C A  C  PP +S   LE  +   F 
Sbjct: 3029 MCQPGYTMELNGSRIRTCTINGTW----SGVMPTCRAVTCPTPPQISNGRLEGTN---FD 3081

Query: 2104 AGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYS 2163
             G  +S+ C  G+ L+  A + C+  G W  S    QC+P  CG+P     G   G ++ 
Sbjct: 3082 WGFSISYICSPGYELSFPAVLTCVGNGTW--SGEVPQCLPKFCGDPGIPAQGKREGKSFI 3139

Query: 2164 FGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTC---HPVSCGEPPKVENGFLEHTTG 2220
            + + V++SCN  F + G     C+A G WS   P C      SC  P    +G   +T G
Sbjct: 3140 YQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG 3199

Query: 2221 RIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENF 2280
                S V++ C  G+   GS    C  +  W    P  C+P  C +P    +  + G + 
Sbjct: 3200 FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP-ECIPHSCKQPETPAHANVVGMDL 3258

Query: 2281 -EVGSKVQFFCNEGYELVGDSSW-TCQKSGKWNKK 2313
               G  + + C  G+ L G +    C+    W  K
Sbjct: 3259 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGK 3293



 Score =  303 bits (777), Expect = 2e-81
 Identities = 236/868 (27%), Positives = 348/868 (40%), Gaps = 128/868 (14%)

Query: 1436 YGYVMLDGMLPSLHALTCTFWMKSSD------DMNYGTPISYAVDNGSDNTLLLTDYNGW 1489
            YGY   D  +P+  A++C      ++      D   GT ++Y  ++G             
Sbjct: 2511 YGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDG------------- 2557

Query: 1490 VLYVNGREKITNCPSVNDGRWHHIAITWTSANGIWKVYID--GKLSDGGAGLSVGLPIPG 1547
              Y    +++T     +DG       TW++ N   +  +   G+L     G  +G     
Sbjct: 2558 --YRLSSKELTTAVCQSDG-------TWSNHNKTPRCVVISCGELPTPPNGNKIGTQTSY 2608

Query: 1548 GGALVLGQEQDKKGEGFSPAESFVGSISQLNLWDYVLSPQQVKSLATSC--PEELSKGNV 1605
            G   +   +      GF    S V       LW    S  + + LA  C  PE +  G V
Sbjct: 2609 GSTAIFTCDL-----GFMLVGSAVRECLSSGLW----SESETRCLAGHCGIPELIVNGQV 2659

Query: 1606 LAWPDFLSGIV------GKVKIDSKSIFCSDCPRLGGSVPHL--------------RTAS 1645
            +         V      G   I S    C       G +P                RT+ 
Sbjct: 2660 IGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG 2719

Query: 1646 EDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSA-- 1703
                    V   C+ G+ + G     C    QW+ P P C+ ++C  P    N    +  
Sbjct: 2720 NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKI 2779

Query: 1704 --DDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASC 1761
               +F  G+ V Y CN GY+L G S + C  NG W+   P C+ +D              
Sbjct: 2780 EHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMID-------------- 2825

Query: 1762 LNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQL 1821
                                       C  PG P N   SGE YT G+ V +SC     L
Sbjct: 2826 ---------------------------CGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL 2858

Query: 1822 MGVTKITCLESGEWNHLIPYCK---AVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYT 1878
            +G +  TC  +G W+   P+C      +CG P  P +G  +E  F   S V Y C+ GY 
Sbjct: 2859 LGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYI 2918

Query: 1879 LAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGK-YILSGLTYLSTASYSCDTGYSL 1937
            L G +E +CLAN SW+   P C+ V+C +P    NGK + + G T+ S+  YSC  GY L
Sbjct: 2919 LHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYIL 2978

Query: 1938 QGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYT--L 1995
             GPS+ +CTA+G W    P C ++ CG+P    + +  G+++     V+Y C+ GYT  L
Sbjct: 2979 SGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMEL 3038

Query: 1996 AGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLAD 2055
             G     C  +G WS     C AV+C  PP + +   E  +  +G    Y CS GY L+ 
Sbjct: 3039 NGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSF 3098

Query: 2056 NSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEG 2115
             + L C   G W      ++P+C+  FC  P   +    E  S   F   S VSF C   
Sbjct: 3099 PAVLTCVGNGTW----SGEVPQCLPKFCGDPGIPAQGKREGKS---FIYQSEVSFSCNFP 3151

Query: 2116 FVLNTSAKIECMRGGQWN-PSPMSIQCIPVRCGEPPSIMNGYASGS-NYSFGAMVAYSCN 2173
            F+L  S+   C   G W+  SP  I+     C  P    +G  + +  +  G++V + C 
Sbjct: 3152 FILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCK 3211

Query: 2174 KGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESE---VRYQ 2230
            KG  ++G    TC     WS   P C P SC +P   E     +  G    S    + Y 
Sbjct: 3212 KGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQP---ETPAHANVVGMDLPSHGYTLIYT 3268

Query: 2231 CNPGYKSVGSPVF-VCQANRHWHSESPL 2257
            C PG+   G     VC+++  W  + P+
Sbjct: 3269 CQPGFFLAGGTEHRVCRSDNTWTGKVPI 3296



 Score =  107 bits (268), Expect = 2e-22
 Identities = 289/1400 (20%), Positives = 477/1400 (34%), Gaps = 318/1400 (22%)

Query: 2101 KFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPS---PMSIQCIPVRCG---------- 2147
            +F  G  + + C+ G++L+   ++ C+       S   P+ I      CG          
Sbjct: 193  RFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGII 252

Query: 2148 EPPSIMNGYASGSNYSFGAMV----AYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVS 2203
              PS  N Y + ++ ++  +       S     +   EK    E  G   S  PT     
Sbjct: 253  SSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEG---SEPPTIWLSG 309

Query: 2204 CGEPPKVENG-------FLEHTTGRIFESEVRYQCNPG--YKSVGSPVFVCQANRHWHS- 2253
               PP + +        F+  +  R       YQ      +KS G  +F  + N +  S 
Sbjct: 310  MNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSRGFKLFPGKDNSNKFSI 369

Query: 2254 --ESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGK-- 2309
              E  +      C  P   +NG   G +F +GS VQF C+E Y L G  S TCQ+  +  
Sbjct: 370  LNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVF 429

Query: 2310 --WNKKSNPKCMPAKC-------------PEPPLLEN------------------QLVLK 2336
              W+    P C    C             P  P   +                  Q+  +
Sbjct: 430  AAWS-DHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFE 488

Query: 2337 ELTTEVGVVTFSCKEG----------HVLQG---PSVLKCLPSQQW-------------- 2369
            E   E+G  T +  +G           VL G   P ++  + SQ W              
Sbjct: 489  EFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGF 548

Query: 2370 NDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWS 2429
              ++   +   C  P    +G+            +++ C  GF L G  + +CQ +  WS
Sbjct: 549  KVNYKEIEKESCGDPGTPLYGIR-EGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWS 607

Query: 2430 SPLPECVPVECPQPEEIPNGII----DVQGLAYLSTALYT--CKPG---------FELVG 2474
            + +P C+   C      P G +      +G       ++T    PG         F+L  
Sbjct: 608  ANIPICI-FPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES 666

Query: 2475 NTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPS 2534
                L  ++G                P+  + G F+  ++    T   S +   RLE  +
Sbjct: 667  QFDFLAVKDGD--------------SPESPILGTFTGAEVPSHLT---SNSHILRLEFQA 709

Query: 2535 ALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGF-QVAGHAM 2593
              +    G +++   +     C  P    N    G ++  G+ I   C  GF +  G   
Sbjct: 710  DHSMSGRG-FNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTET 768

Query: 2594 QTC----EESGWSSSIPTC-------------------------MPIDCGLPPHIDFGDC 2624
             TC     +  WS  IP C                           ++C      + G  
Sbjct: 769  ITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHS 828

Query: 2625 TKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHS-SNFLY--GTMV 2681
             K+  ++   E   D++EV       P  L  +  ++  T+      S SNF+Y   T  
Sbjct: 829  IKITFERFQTELNYDVLEV----HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTD 884

Query: 2682 SYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQY 2741
            +   N G+++    V +         +  SC+      P  P +G     + S+GS V +
Sbjct: 885  NSRSNNGFKIHYESVTV---------NTYSCLD-----PGIPVHGRRYGHDFSIGSTVSF 930

Query: 2742 SCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYEC 2801
            SC  G+ L+  +  LC +N  WS   P C+A+          G ++G + T LS  Y E 
Sbjct: 931  SCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--------CGGDVRGPSGTILSPGYPEF 982

Query: 2802 DPG-----YVLNGTERRTCQDD----------------KNWDEDEPICIPVDCSSPPVSA 2840
             P      + ++ T  +  Q +                +N    +P+        PP + 
Sbjct: 983  YPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPP-TI 1041

Query: 2841 NGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANG 2900
            N  + G+   F+ ++ +  +     EG        N              C  P     G
Sbjct: 1042 NAGLYGN---FRAQLRFISDFSISYEGFNITFSEYNLE-----------PCEDPGIPQYG 1087

Query: 2901 VTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGN--WDAEIPLCKPVNCGPPED---- 2954
               G ++G    +TF C  GY L G  ++ C   G   W A +P C    CG        
Sbjct: 1088 SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC-VAECGASATNNEG 1146

Query: 2955 --LAHGFPNGFSFIHG--GHIQYQCFPG---------------YKLHGNSSRRCLSNGSW 2995
              L+  +P  +   H     IQ Q   G                K++    +     G++
Sbjct: 1147 ILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAF 1206

Query: 2996 SGSSPSCLPCRCSTPV--IEYGT-VNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQW 3052
            +G+S   L    ++    +E+ +   GTD            +GF+L+             
Sbjct: 1207 TGASMRGLTLSSTSNQLWLEFNSDTEGTD------------EGFQLV-----------YT 1243

Query: 3053 SSGFPHCEHTSCGSLPMIP--NAFISETSSWKENVITYSCRSGYVIQGSSDLICT--EKG 3108
            S    HCE       P IP     IS+   +  + I Y C  GY + GSS L C   E+ 
Sbjct: 1244 SFELSHCED------PGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERR 1297

Query: 3109 VWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGR 3168
             W  P P C     G     ++       + +  +  LRC+  + ++ D       +   
Sbjct: 1298 AWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCM--WMIEVDPGNIVSLQFLA 1355

Query: 3169 WFPE------RISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQ 3222
            +  E      R+   P     PEN   +          +++S S         +NI   Q
Sbjct: 1356 FDTEASHDILRVWDGP-----PENDMLL----------KEISGSLIPEGIHSTLNIVTIQ 1400

Query: 3223 LDGTW---EPPFSDESCSPV--SCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNR 3277
             D  +   +  F+ +  S V  +C  P  P +G   G       T+++QC+PGYEL+G  
Sbjct: 1401 FDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEE 1460

Query: 3278 ERVC--QENRQ-WSGGVAIC 3294
               C   ENR  W     +C
Sbjct: 1461 RITCIQVENRYFWQPSPPVC 1480



 Score =  107 bits (268), Expect = 2e-22
 Identities = 296/1393 (21%), Positives = 465/1393 (33%), Gaps = 236/1393 (16%)

Query: 1620 KIDSKSIFCSDCPRLGGSVP-HLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQW 1678
            KI  +S+  +    L   +P H R    D   GS V+  CD G++L       C     W
Sbjct: 893  KIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWW 952

Query: 1679 TQPLPHCERISCG--VPPP----LENGFHSADDFYAGS-------TVTY----QCNNGYY 1721
            + PLP C+ + CG  V  P    L  G+    +FY  S        VT+    Q N   +
Sbjct: 953  SHPLPTCDAL-CGGDVRGPSGTILSPGY---PEFYPNSLNCTWTVDVTHGKGVQFNFHTF 1008

Query: 1722 LLGDSR--MFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASC-----LNVDGSYICSCVP 1774
             L D    +  T+NGS+               GSD     +            +I     
Sbjct: 1009 HLEDHHDYLLITENGSFTQPLAR-------LTGSDLPPTINAGLYGNFRAQLRFISDFSI 1061

Query: 1775 PYTGDGKNCAE--PIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLES 1832
             Y G     +E     C+ PG P+ G   G  + +G  +TFSC  GY+L G ++I CL  
Sbjct: 1062 SYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGG 1121

Query: 1833 GE--WNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLAN 1890
            G   W+  +P C A  CG  A    G +    +    +  + C     +   K  +  A 
Sbjct: 1122 GRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISAR 1180

Query: 1891 SSWSHSPPVCEPVKCSSPENINNGKYI---LSGLTYLSTASYSCDTGYSLQGPSIIECTA 1947
            +       V +            G +    + GLT  ST++        L+  S  E T 
Sbjct: 1181 TFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQ-----LWLEFNSDTEGTD 1235

Query: 1948 SGIWDRAPPACHLVFCGEP--PAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLA 2005
             G +     +  L  C +P  P     +    +F   +T+ Y C  GYTL G   ++C+ 
Sbjct: 1236 EG-FQLVYTSFELSHCEDPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCMT 1293

Query: 2006 DGK--WSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNA 2063
              +  W      C+A              E   R  G+ +    S GY    ++ L C  
Sbjct: 1294 GERRAWDYPLPSCIA--------------ECGGRFKGESSGRILSPGYPFPYDNNLRCMW 1339

Query: 2064 QGKWVPPEGQDMPRCIAHFCEKPPSVSYSIL-------ESVSKAKFAAGSVVSFKCMEGF 2116
              +  P     +      F       S+ IL       E+    K  +GS++     EG 
Sbjct: 1340 MIEVDPGNIVSL-----QFLAFDTEASHDILRVWDGPPENDMLLKEISGSLIP----EGI 1390

Query: 2117 --VLNTSAKIECMRGGQWNPSPMSIQ---CIPVRCGEPPSIMNGYASGSNYSFGAMVAYS 2171
               LN    I+       + S  +IQ    +   C +P   MNG  +G     G  V + 
Sbjct: 1391 HSTLNI-VTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQ 1449

Query: 2172 CNKGFYIKGEKKSTC---EATGQWSSPIPTCHPVSCGEPPKVENGFL-----EHTTGRIF 2223
            C+ G+ ++GE++ TC   E    W    P C    CG      +GF+      H      
Sbjct: 1450 CDPGYELQGEERITCIQVENRYFWQPSPPVC-IAPCGGNLTGSSGFILSPNFPHPYPHSR 1508

Query: 2224 ESEVRYQCNPGYK-SVGSPVFVCQANRHW-------HSESPLMCVPLDCGKPPPIQNGFM 2275
            + +     N  Y  S+    F  + N  +        S SPL+    D   P        
Sbjct: 1509 DCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLP-------- 1560

Query: 2276 KGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVL 2335
              E  E  S            V  + +  +   K         +   C +P  + N   L
Sbjct: 1561 --ERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK---------LRESCFDPGNIMNGTRL 1609

Query: 2336 KELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQ----WNDSFPVC-------------KI 2378
                     VT+ C  G+VLQG S L C+        WN + P C              +
Sbjct: 1610 GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTV 1669

Query: 2379 VLCTPPPLISFG------VPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDG-TWSSP 2431
            +    P   S G      + +P   + FG  V       FF       +   DG T  S 
Sbjct: 1670 LSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFV-------FFQTSLHDVVEVYDGPTQQSS 1722

Query: 2432 LPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKP 2491
            L   +       E +P    +   + + S    T K GF  V                 P
Sbjct: 1723 LLSSLS-GSHSGESLPLSSGNQITIRFTSVGPITAK-GFHFVYQAV-------------P 1767

Query: 2492 TCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLET-----GDWDV 2546
               + +C    E   G+    +   G +V + CN G+ L G  A+ C ET       W+ 
Sbjct: 1768 RTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRC-ETVPNSLAQWND 1826

Query: 2547 DAPSCNAIHCD------SPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG 2600
              P+C  + C           +  G+ E  D +   +   +   G  +    +    E  
Sbjct: 1827 SLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN 1885

Query: 2601 WSS---------SIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPP 2651
            W S         + P          PH+       L     Y   + D+           
Sbjct: 1886 WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNL-----YLNFQSDIS-----VSAAG 1935

Query: 2652 YHLGAVAKTWENTKESPATHSS------NFLYGTMVSYTCNPGYELLGNPVLICQEDGT- 2704
            +HL   A   ++  E P T SS       ++ G +VS+ C+ GY L G+  + C      
Sbjct: 1936 FHLEYTAIGLDSCPE-PQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVR 1994

Query: 2705 -WNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCK-PGHILAGSDLRLCLENRK 2762
             WN   P C++ +C    +  +G +              C    ++  G  + L   N  
Sbjct: 1995 RWNYPIPICLA-QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFS 2053

Query: 2763 WSGASPRCEAISCKKPNPVMNGSIKGS-------NYTYLSTLYYECDPGYVLNGTERRTC 2815
                    E  S       + G + G        + T+ ++LY+  D             
Sbjct: 2054 TETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSD-----------YS 2102

Query: 2816 QDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCL- 2874
            Q+ + +           C  P    NG V G+++T  + I + C  G+ L G  +  CL 
Sbjct: 2103 QNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLH 2162

Query: 2875 -ANGSWSGATPDC 2886
              + +W+   P C
Sbjct: 2163 GVSRNWNHPLPRC 2175



 Score = 85.5 bits (210), Expect = 9e-16
 Identities = 57/216 (26%), Positives = 91/216 (42%), Gaps = 20/216 (9%)

Query: 359  DCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSII 418
            +C+    +  S   C   HC   +   NG  I    N  +      +C+PGF L+GSS+ 
Sbjct: 2629 ECLSSGLWSESETRCLAGHCGIPELIVNGQVIGE--NYGYRDTVVYQCNPGFRLIGSSVR 2686

Query: 419  LCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKL 478
            +C  +  WSG    C   +C H   P +G    S     +      +C+ GY ++G  K 
Sbjct: 2687 ICQQDHNWSGQLPSCVPVSCGHPGSPIYGR--TSGNGFNFNDVVTFSCNIGYLMQGPTKA 2744

Query: 479  TCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAK-------FGTICYVSCRQ 531
             CQ N QW  P P C   +CS   +P +         K+ +K       +GT+ +  C  
Sbjct: 2745 QCQANRQWSHPPPMCKVVNCSDPGIPAN--------SKRESKIEHGNFTYGTVVFYDCNP 2796

Query: 532  GFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQI 567
            G+ L G   +L C  +G+W+  +   +  D   P +
Sbjct: 2797 GYFLFG-SSVLICQPNGQWDKPLPECIMIDCGHPGV 2831



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 139/641 (21%), Positives = 224/641 (34%), Gaps = 119/641 (18%)

Query: 1698 NGFHSADDFYAGSTVTYQCNNGYYLL-GDSRMFCT---DNGSWNGVSPSCLDVDECAVGS 1753
            N     D+F  GS+++  C  G+    G   + C        W+G+ P C        G+
Sbjct: 738  NARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC--------GA 789

Query: 1754 DCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNP----------ENGHSSGE 1803
             C  H S  +  G  +    P Y  D  NC   I+ + PG+           E  +   E
Sbjct: 790  PCGGHFSAPS--GVILSPGWPGYYKDSLNCEWVIEAE-PGHSIKITFERFQTELNYDVLE 846

Query: 1804 IY---------------TVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYC-KAVSC 1847
            ++               T   +  FS      L+  T  +   +G   H         SC
Sbjct: 847  VHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 906

Query: 1848 GKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSS 1907
              P IP +G      F+ GS V++ C+ GY L+ ++   C  N  WSH  P C+ + C  
Sbjct: 907  LDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL-CGG 965

Query: 1908 PENINNGKYILSG----------------LTYLSTASYSCDTGYSLQGPSIIECTASGIW 1951
                 +G  +  G                +T+     ++  T +       +  T +G +
Sbjct: 966  DVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSF 1025

Query: 1952 DRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSR 2011
             +  P   L     PP I +A + GN   FR  + +      +  G +            
Sbjct: 1026 TQ--PLARLTGSDLPPTI-NAGLYGN---FRAQLRFISDFSISYEGFNI----------- 1068

Query: 2012 SDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGK--WVP 2069
            +  +     C++P I  + S    +   GD   + CS GY L   S+++C   G+  W  
Sbjct: 1069 TFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSA 1128

Query: 2070 PEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRG 2129
            P    +PRC+A  C    + +  IL S                   + LN     EC+  
Sbjct: 1129 P----LPRCVAE-CGASATNNEGILLS-----------------PNYPLNYENNHECIYS 1166

Query: 2130 GQWNPSP---MSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKG------ 2180
             Q        +S +   +  G+   I +G    + +  GA    S  +G  +        
Sbjct: 1167 IQVQAGKGINISARTFHLAQGDVLKIYDG-KDKTTHLLGAFTGASM-RGLTLSSTSNQLW 1224

Query: 2181 -EKKSTCEATGQWSSPIPTCHPVS-CGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSV 2238
             E  S  E T +    + T   +S C +P   + G+     G    S + Y CNPGY   
Sbjct: 1225 LEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLH 1284

Query: 2239 GSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGEN 2279
            GS +  C        + PL     +CG       G  KGE+
Sbjct: 1285 GSSLLKCMTGERRAWDYPLPSCIAECG-------GRFKGES 1318



 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 252/1237 (20%), Positives = 409/1237 (33%), Gaps = 316/1237 (25%)

Query: 2203 SCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPL----- 2257
            SCG+P     G  E   G      +R++C  G++ +G    VCQ N  W +  P+     
Sbjct: 559  SCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 617

Query: 2258 ---MCVPLDCGKPPPIQNGFMKGEN------FEVGSKVQFFCNEGYELVGDSSWTCQKSG 2308
                  P+     P    G+    N       + GS++    N+ ++L     +   K G
Sbjct: 618  LSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFND-FDLESQFDFLAVKDG 676

Query: 2309 KWNKKSNPKCMPAKCPEPPLL---ENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLP 2365
                           PE P+L       V   LT+   ++    +  H + G        
Sbjct: 677  -------------DSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSG-------- 715

Query: 2366 SQQWNDSFPVCKIVLCTPPPLISFGVPIPS----SALHFGSTVKYSCVGGFF-LRGNSTT 2420
             + +N ++       C  P     G+PI +         GS++   C  GF   +G  T 
Sbjct: 716  -RGFNITYNTFGHNECPDP-----GIPINARRFGDNFQLGSSISVICEEGFIKTQGTETI 769

Query: 2421 LC-QPDG--TWSSPLPECVPVECPQPEEIPNGIIDVQGL-AYLSTAL-----YTCKPG-- 2469
             C   DG   WS  +P+C    C      P+G+I   G   Y   +L        +PG  
Sbjct: 770  TCILMDGKVMWSGLIPKC-GAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHS 828

Query: 2470 -------FELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTY 2522
                   F+   N   L   +G  L   P   +    +  + L    ++  L +  T   
Sbjct: 829  IKITFERFQTELNYDVLEVHDGPNL-LSPLLGSYNGTQVPQFLFSSSNFIYLLF-TTDNS 886

Query: 2523 SCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSC 2582
              N GF++                ++ + N   C  P    +G   G D+S G+ + +SC
Sbjct: 887  RSNNGFKIH--------------YESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSC 932

Query: 2583 FPGFQVAGHAMQTCEES-GWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMM 2641
              G++++      CE++  WS  +PTC  + CG       GD   ++   G         
Sbjct: 933  DSGYRLSHEEPLLCEKNHWWSHPLPTCDAL-CG-------GD---VRGPSG--------- 972

Query: 2642 EVPYVTP-HPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQ 2700
                ++P +P ++  ++  TW          + +  +G  V +  +  +    +  L+  
Sbjct: 973  --TILSPGYPEFYPNSLNCTW----------TVDVTHGKGVQFNFHTFHLEDHHDYLLIT 1020

Query: 2701 EDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN 2760
            E+G++  + P       DLP     G              Y      +   SD  +  E 
Sbjct: 1021 ENGSF--TQPLARLTGSDLPPTINAGL-------------YGNFRAQLRFISDFSISYEG 1065

Query: 2761 RKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDD-- 2818
               + +    E   C+ P     GS  G N+    TL + C  GY L GT    C     
Sbjct: 1066 FNITFSEYNLE--PCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGR 1123

Query: 2819 KNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTC------------------- 2859
            + W    P C+  +C +   +  G +    Y    E  + C                   
Sbjct: 1124 RVWSAPLPRCV-AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTF 1182

Query: 2860 --NEGFLLE--GARSRVCLANGSWSGATPDCVPVRCATPPQL---ANGVTEGLDYGFMKE 2912
               +G +L+    + +     G+++GA+   + +  +T  QL    N  TEG D GF   
Sbjct: 1183 HLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTL-SSTSNQLWLEFNSDTEGTDEGFQLV 1241

Query: 2913 VT----FHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHG 2968
             T     HC +  I     K++ Q                         G   G + I+G
Sbjct: 1242 YTSFELSHCEDPGIPQFGYKISDQ-------------------------GHFAGSTIIYG 1276

Query: 2969 GHIQYQCFPGYKLHGNSSRRCLS--NGSWSGSSPSCL-PC----------RCSTPVIEYG 3015
                  C PGY LHG+S  +C++    +W    PSC+  C          R  +P   + 
Sbjct: 1277 ------CNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFP 1330

Query: 3016 TVNG------TDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPM 3069
              N        + D G    +Q F  F      +I    DG   +            L  
Sbjct: 1331 YDNNLRCMWMIEVDPGNIVSLQ-FLAFDTEASHDILRVWDGPPENDM---------LLKE 1380

Query: 3070 IPNAFISETSSWKENVIT-------YSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSC 3122
            I  + I E      N++T       Y  +SG+ IQ SS +                  +C
Sbjct: 1381 ISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSV----------------ATAC 1424

Query: 3123 GSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCP 3182
              P    N    G+       V  +C  GY +  +      Q + R+F +    SP  C 
Sbjct: 1425 RDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQP---SPPVCI 1481

Query: 3183 LP--------------ENITHILVHGDD----FSVNRQVSVSCA-----------EGYTF 3213
             P               N  H   H  D     +VN    +S A             Y +
Sbjct: 1482 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1541

Query: 3214 EGVNISVCQLDGTWEP---PFSDESCSPV--------------------------SCGKP 3244
            +G + S   L G+++    P   ES S                            SC  P
Sbjct: 1542 DGPD-SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP 1600

Query: 3245 ESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVC 3281
             +  +G  +G  Y   ST+ Y C+ GY L+G     C
Sbjct: 1601 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTC 1637



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 49/157 (31%), Positives = 65/157 (41%), Gaps = 10/157 (6%)

Query: 398  FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCR---VRTCPHLRQPKHGHISCSTR 454
            F +     C     L+G S   C  NG WSGS+ +C      TC     P HG  S    
Sbjct: 2844 FGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG--SRQES 2901

Query: 455  EMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNC 514
                K+T   ACD GY L GS++ TC  N  W G +P C    C           +    
Sbjct: 2902 NFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGN----PGTTANGKVF 2957

Query: 515  GKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
                  F +    SC +G+ILSG   + +CT +G W+
Sbjct: 2958 RIDGTTFSSSVIYSCMEGYILSG-PSVRQCTANGTWS 2993



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 66/251 (26%), Positives = 95/251 (37%), Gaps = 30/251 (11%)

Query: 315  GLQYECTACPSGT---------YKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREG 365
            G Q EC A   G          ++ +G+    S    C +    S P   S   C     
Sbjct: 2935 GRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGP---SVRQCTANGT 2991

Query: 366  YRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGF--DLVGSSIILCLPN 423
            +  +   C ++ C     P NG    +      N +    C PG+  +L GS I  C  N
Sbjct: 2992 WSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVS--YMCQPGYTMELNGSRIRTCTIN 3049

Query: 424  GLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGN 483
            G WSG    CR  TCP   Q  +G +  +  +  +  + +  C  GY L     LTC GN
Sbjct: 3050 GTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYI--CSPGYELSFPAVLTCVGN 3107

Query: 484  SQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAK---FGTICYVSCRQGFILSGVKE 540
              W G  P+C+ + C    +P          GK+  K   + +    SC   FIL G   
Sbjct: 3108 GTWSGEVPQCLPKFCGDPGIPAQ--------GKREGKSFIYQSEVSFSCNFPFILVGSST 3159

Query: 541  MLRCTTSGKWN 551
             + C   G W+
Sbjct: 3160 RI-CQADGTWS 3169



 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 101/450 (22%), Positives = 169/450 (37%), Gaps = 67/450 (14%)

Query: 1785 EPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKA 1844
            E   C  PG P  G   G+ ++    + F CQ G++L+G   I C E+ +W+  IP C  
Sbjct: 556  EKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF 615

Query: 1845 VSCGK----------PAIPEN-----GCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLA 1889
                           P  PE       CI  +    GS++    N  + L    +   + 
Sbjct: 616  PCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFND-FDLESQFDFLAVK 674

Query: 1890 NSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASG 1949
            +     SP +        P ++ +  +IL          +  D   S +G +I   T   
Sbjct: 675  DGDSPESPILGTFTGAEVPSHLTSNSHILR-------LEFQADHSMSGRGFNITYNTFGH 727

Query: 1950 IWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLA-GLDTIEC-LADG 2007
                         C +P    +A   G+NF   ++++  C+EG+    G +TI C L DG
Sbjct: 728  NE-----------CPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDG 776

Query: 2008 K--WSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQG 2065
            K  WS    +C A      P   H S  +   L      YY            L C    
Sbjct: 777  KVMWSGLIPKCGA------PCGGHFSAPSGVILSPGWPGYY---------KDSLNC---- 817

Query: 2066 KWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCME--GFVLNTSAK 2123
            +WV  E +        F      ++Y +LE        +  + S+   +   F+ ++S  
Sbjct: 818  EWVI-EAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNF 876

Query: 2124 IECM----RGGQWNPSPMSIQCIPVR---CGEPPSIMNGYASGSNYSFGAMVAYSCNKGF 2176
            I  +         N   +  + + V    C +P   ++G   G ++S G+ V++SC+ G+
Sbjct: 877  IYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGY 936

Query: 2177 YIKGEKKSTCEATGQWSSPIPTCHPVSCGE 2206
             +  E+   CE    WS P+PTC  +  G+
Sbjct: 937  RLSHEEPLLCEKNHWWSHPLPTCDALCGGD 966



 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 68/245 (27%), Positives = 97/245 (39%), Gaps = 36/245 (14%)

Query: 335  GGISSCIPCPDENHTSPP-GSTSPE-----DCV---CREGYRASGQT------------- 372
            G + SC+P    +  SP  G TS       D V   C  GY   G T             
Sbjct: 2696 GQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHP 2755

Query: 373  ---CELVHCPALKPPENGYFIQNTCNNHFNAACGV--RCHPGFDLVGSSIILCLPNGLWS 427
               C++V+C     P N        + +F     V   C+PG+ L GSS+++C PNG W 
Sbjct: 2756 PPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWD 2815

Query: 428  GSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWD 487
                 C +  C H   P +  +S    +  + +T   +C     L G    TCQ N  W 
Sbjct: 2816 KPLPECIMIDCGHPGVPPNAVLS--GEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWS 2873

Query: 488  GPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYV--SCRQGFILSGVKEMLRCT 545
            G +P C      T   P     +P +  +Q + F T   V  +C  G+IL G +E   C 
Sbjct: 2874 GSQPHCSGDATGTCGDPG----TPGHGSRQESNFRTKSTVRYACDTGYILHGSEER-TCL 2928

Query: 546  TSGKW 550
             +G W
Sbjct: 2929 ANGSW 2933



 Score = 72.4 bits (176), Expect = 8e-12
 Identities = 56/210 (26%), Positives = 83/210 (39%), Gaps = 30/210 (14%)

Query: 362  CREGYRASGQT--------------------CELVHCPALKPPENGYFIQNTCNNHFNAA 401
            C +GYR S +                     C ++ C  L  P NG  I    +  + + 
Sbjct: 2554 CNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGNKIGTQTS--YGST 2611

Query: 402  CGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTT 461
                C  GF LVGS++  CL +GLWS SE+ C    C       +G +        Y+ T
Sbjct: 2612 AIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQV--IGENYGYRDT 2669

Query: 462  CLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKF 521
             +  C+ G+RL GS    CQ +  W G  P CV   C     P    I     G     F
Sbjct: 2670 VVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSP----IYGRTSG-NGFNF 2724

Query: 522  GTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
              +   SC  G+++ G  +  +C  + +W+
Sbjct: 2725 NDVVTFSCNIGYLMQGPTK-AQCQANRQWS 2753



 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 54/195 (27%), Positives = 77/195 (39%), Gaps = 12/195 (6%)

Query: 361  VCREGYRASGQ--TCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSII 418
            +C++ +  SGQ  +C  V C     P  G    N  N  FN      C+ G+ + G +  
Sbjct: 2687 ICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFN--FNDVVTFSCNIGYLMQGPTKA 2744

Query: 419  LCLPNGLWSGSESYCRVRTC--PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSD 476
             C  N  WS     C+V  C  P +                Y T     C+ GY L GS 
Sbjct: 2745 QCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSS 2804

Query: 477  KLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILS 536
             L CQ N QWD P P C+   C    +P + ++S      +   FG+  + SC     L 
Sbjct: 2805 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLS-----GEKYTFGSTVHYSCTGKRSLL 2859

Query: 537  GVKEMLRCTTSGKWN 551
            G +    C  +G W+
Sbjct: 2860 G-QSSRTCQLNGHWS 2873



 Score = 70.1 bits (170), Expect = 4e-11
 Identities = 51/200 (25%), Positives = 82/200 (41%), Gaps = 15/200 (7%)

Query: 372  TCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSES 431
            TC  V CP      NG  ++ T N  +  +    C PG++L   +++ C+ NG WSG   
Sbjct: 3058 TCRAVTCPTPPQISNGR-LEGT-NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVP 3115

Query: 432  YCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEP 491
             C  + C     P  G      +  +Y++    +C+  + L GS    CQ +  W G  P
Sbjct: 3116 QCLPKFCGDPGIPAQG--KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSP 3173

Query: 492  RCVERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQGFILSGVKEMLRCTTSGK 549
             C+E   ++ + P    +  H        F  G++    C++G +L G      C     
Sbjct: 3174 HCIEPTQTSCENPG---VPRHGSQNNTFGFQVGSVVQFHCKKGHLLQG-STTRTCLPDLT 3229

Query: 550  WNVGVQAAV----CKDVEAP 565
            W+ G+Q       CK  E P
Sbjct: 3230 WS-GIQPECIPHSCKQPETP 3248



 Score = 70.1 bits (170), Expect = 4e-11
 Identities = 52/195 (26%), Positives = 81/195 (41%), Gaps = 20/195 (10%)

Query: 406  CHPGFDLVGSSIILCLPNGLWSGSESYCRVRT---CPHLRQPKHGHISCSTREMLYKTTC 462
            C+  F LVGSS  +C  +G WSGS  +C   T   C +   P+HG  + +T      +  
Sbjct: 3148 CNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVV 3206

Query: 463  LVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFG 522
               C +G+ L+GS   TC  +  W G +P C+   C   + P    +     G      G
Sbjct: 3207 QFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANV----VGMDLPSHG 3262

Query: 523  TICYVSCRQGFILSGVKEMLRCTTSGKWNVGV------QAAVCKD------VEAPQINCP 570
                 +C+ GF L+G  E   C +   W   V         + KD        +P+++ P
Sbjct: 3263 YTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTPSPKLSVP 3322

Query: 571  KDIEAKTLEQQDSAN 585
             D+ A+    + S N
Sbjct: 3323 DDVFAQNYIWKGSYN 3337



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 156/783 (19%), Positives = 276/783 (35%), Gaps = 108/783 (13%)

Query: 2680 MVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAV 2739
            ++ + C  G+EL+G   ++CQE+  W+ + P CI       TAP  G +   +   G   
Sbjct: 581  VLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPM-GTVLSPDYPEGYGN 639

Query: 2740 QYSCKPGHIL-AGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNY------- 2791
              +C    I   GS + L   +                 P   + G+  G+         
Sbjct: 640  NLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSN 699

Query: 2792 TYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTF 2851
            +++  L ++ D  + ++G       +    +E         C  P +  N +  GD +  
Sbjct: 700  SHILRLEFQAD--HSMSGRGFNITYNTFGHNE---------CPDPGIPINARRFGDNFQL 748

Query: 2852 QKEIEYTCNEGFL-LEGARSRVC-LANGS--WSGATPDCVPVRCATPPQLANGVTEGLDY 2907
               I   C EGF+  +G  +  C L +G   WSG  P C    C       +GV     +
Sbjct: 749  GSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC-GAPCGGHFSAPSGVILSPGW 807

Query: 2908 -GFMKEVTFHCHEGYILHGAP----KLTC---QSDGNWDAEIPLCKPVNCGPPEDLAHGF 2959
             G+ K+ + +C   +++   P    K+T    Q++ N+D       P    P     +G 
Sbjct: 808  PGYYKD-SLNCE--WVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGT 864

Query: 2960 PNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNG 3019
                      +  Y  F       N+  + +   S + ++ SCL      PV  +G   G
Sbjct: 865  QVPQFLFSSSNFIYLLFTTDNSRSNNGFK-IHYESVTVNTYSCLDP--GIPV--HGRRYG 919

Query: 3020 TDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFI---- 3075
             DF  G      C  G++L     + CE +  WS   P C+   CG     P+  I    
Sbjct: 920  HDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCD-ALCGGDVRGPSGTILSPG 978

Query: 3076 -------SETSSWKENV-----ITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCG 3123
                   S   +W  +V     + ++  + ++      L+ TE G ++QP      L+  
Sbjct: 979  YPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQP---LARLTGS 1035

Query: 3124 SPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCP- 3182
              P   NA   G         +LR +  +++  +    T  +         +  P + P 
Sbjct: 1036 DLPPTINAGLYG-----NFRAQLRFISDFSISYEGFNITFSE--------YNLEPCEDPG 1082

Query: 3183 LPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDG--TWEPPFSDESCSPVS 3240
            +P+  + I   G +F +   ++ SC+ GY  EG +  +C   G   W  P          
Sbjct: 1083 IPQYGSRI---GFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPR---CVAE 1136

Query: 3241 CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKET--- 3297
            CG   +   G ++   Y                E N E +     Q   G+ I   T   
Sbjct: 1137 CGASATNNEGILLSPNYPL------------NYENNHECIYSIQVQAGKGINISARTFHL 1184

Query: 3298 RCETPLEFLNGK---ADIENRTTGPNV----VYSCNRGYSLEGPSEAHCTENGTWSHPVP 3350
                 L+  +GK     +    TG ++    + S +    LE  S+   T+ G +     
Sbjct: 1185 AQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEG-FQLVYT 1243

Query: 3351 LCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDE--TWTQTS 3408
              + + C  P +      +S++  +    +   C  G+ L G  ++ C   E   W    
Sbjct: 1244 SFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPL 1303

Query: 3409 AKC 3411
              C
Sbjct: 1304 PSC 1306



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 102/487 (20%), Positives = 170/487 (34%), Gaps = 66/487 (13%)

Query: 3036 FKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYV 3095
            F L   S+    A G +   +   + +SCG+  + P   +  T     + I YSC +GY+
Sbjct: 151  FSLRLTSDFAVSAHG-FKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYI 209

Query: 3096 IQGSSDLICTEKGV----WSQPYPVCEPL-SCGSPPSVANAVATGEAHTYESEVKLRCL- 3149
            + G   L C    V    W  P P+C    +CG     ++ + +  +   E      C  
Sbjct: 210  LDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTW 269

Query: 3150 -----EGYTMDTDTDTFTCQKDGRWF------PERISCSPKKCPLP--ENITHILVHGDD 3196
                  G T+      F  ++   +       P  I  S    P P   N   + +H   
Sbjct: 270  TIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVT 329

Query: 3197 FSVNRQVSVSC------AEGYTFEGVNISVCQLDGTWEPPFSDESCSPVS--CGKPESPE 3248
             S +R    S       A  +   G  +   + +       ++      S  C  P  PE
Sbjct: 330  DSNHRYRGFSAPYQVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPE 389

Query: 3249 HGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQ----WSGGVAICKETRCETPLE 3304
            +G  +GS ++  ST+ + C+  Y L+G +   CQ   +    WS    +CK   C + L+
Sbjct: 390  NGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQ 449

Query: 3305 FLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIP 3364
              +G        T PN        +  +  S A C    T  +   + + N       I 
Sbjct: 450  GPSG------TFTSPN--------FPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIG 495

Query: 3365 ENAL-LSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSA-------------- 3409
             + L + +     D    ++   G  +    +I     + W                   
Sbjct: 496  YDTLTIGDGGEVGDPRTVLQVLTGSFVP--DLIVSMSSQMWLHLQTDESVGSVGFKVNYK 553

Query: 3410 KCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICR 3469
            + EK SCG P      I  G  +   D++ + C  G+ L G    VC EN  W++     
Sbjct: 554  EIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSAN---I 610

Query: 3470 AVCRFPC 3476
             +C FPC
Sbjct: 611  PICIFPC 617



 Score = 65.5 bits (158), Expect = 9e-10
 Identities = 68/272 (25%), Positives = 106/272 (38%), Gaps = 49/272 (18%)

Query: 3240 SCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRC 3299
            SC  P  P HG   G  ++  ST+ + C+ GY L      +C++N  WS  +  C +  C
Sbjct: 905  SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC-DALC 963

Query: 3300 ETPL-------------EFLNGKADIE---NRTTGPNVVYSCNRGYSLEGPSEAHCTENG 3343
               +             EF     +     + T G  V ++ +  +  +       TENG
Sbjct: 964  GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENG 1023

Query: 3344 TWSHPVPLCKPNPCPVPFVIPENALL-----SEKEFYVDQNVSIKCREGFLLQGHGIITC 3398
            +++ P+     +  P       NA L     ++  F  D ++S    EGF +        
Sbjct: 1024 SFTQPLARLTGSDLPPTI----NAGLYGNFRAQLRFISDFSISY---EGFNI-------- 1068

Query: 3399 NPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLE 3458
                    T ++     C  P   +     G ++  GD +T+SC SGY LEG    +CL 
Sbjct: 1069 --------TFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLG 1120

Query: 3459 NG--TWTSP-PICRAVCRFPCQNG-GICQRPN 3486
             G   W++P P C A C     N  GI   PN
Sbjct: 1121 GGRRVWSAPLPRCVAECGASATNNEGILLSPN 1152



 Score = 60.5 bits (145), Expect = 3e-08
 Identities = 141/655 (21%), Positives = 220/655 (33%), Gaps = 99/655 (15%)

Query: 1689 SCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNG----SWNGVSPSCL 1744
            SCG P     G      F  G  + Y C  GY L G  ++ C  N     SW+   P C 
Sbjct: 177  SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 236

Query: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEI 1804
                       +E A    + GS      P +  +  N A+   C      E G +   I
Sbjct: 237  -----------AEDACGGTMRGSSGIISSPSFPNEYHNNAD---CTWTIVAEPGDTISLI 282

Query: 1805 YTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFT 1864
            +T      F  +E Y  + +      E  E   +  +   ++   P I     +  L F 
Sbjct: 283  FT-----DFQMEEKYDYLEI------EGSEPPTI--WLSGMNIPPPIISNKNWLR-LHFV 328

Query: 1865 FGSKVTYRC--------------NKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPEN 1910
              S   YR               ++G+ L   K++S   +            + C  P  
Sbjct: 329  TDSNHRYRGFSAPYQVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNL-CPDPGE 387

Query: 1911 INNGKYILSGLTYLSTASYSCDTGYSLQGPSIIEC----TASGIWDRAPPACHLVFCGEP 1966
              NGK I S  +  ST  +SCD  Y LQG   I C         W    P C +  CG  
Sbjct: 388  PENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSN 447

Query: 1967 PAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPI 2026
                    T  NF F+      C   + +  ++T + +        ++  L +  D   I
Sbjct: 448  LQGPSGTFTSPNFPFQYDSNAQCV--WVITAVNTNKVIQ----INFEEFDLEIGYDTLTI 501

Query: 2027 VDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQ-GKWVPPEG--QDMPRCIAHFC 2083
             D         +   +   +  D   ++ +SQ+  + Q  + V   G   +        C
Sbjct: 502  GDGGEVGDPRTVLQVLTGSFVPD-LIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 560

Query: 2084 EKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPS-PMSI-QC 2141
              P +  Y I E      F+   V+ F+C  GF L     I C    QW+ + P+ I  C
Sbjct: 561  GDPGTPLYGIREGDG---FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 617

Query: 2142 I-----PVRCGEPPSIMNGYASGSNYSF------GAMVAYSCNKGFYIKGEKKSTCEATG 2190
            +     P+     P    GY +  N  +      G+ +  S N  F ++ +        G
Sbjct: 618  LSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN-DFDLESQFDFLAVKDG 676

Query: 2191 QWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRH 2250
              S   P     +  E P        H T       + +Q +      G   F    N  
Sbjct: 677  D-SPESPILGTFTGAEVP-------SHLTSNSHILRLEFQADHSMSGRG---FNITYNTF 725

Query: 2251 WHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGY-ELVGDSSWTC 2304
             H+E P   +P+         N    G+NF++GS +   C EG+ +  G  + TC
Sbjct: 726  GHNECPDPGIPI---------NARRFGDNFQLGSSISVICEEGFIKTQGTETITC 771



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 75/307 (24%), Positives = 110/307 (35%), Gaps = 43/307 (14%)

Query: 307  CEKGYYGKGLQYECTACPSGTYKPEGSPGGIS---------SCIPCPDENHTSPPGSTSP 357
            C+   +  G Q  C+   +GT    G+PG  S         S +    +      GS   
Sbjct: 2866 CQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGS-EE 2924

Query: 358  EDCVCREGYRASGQTCELVHCPALKPPENG--YFIQNTCNNHFNAACGVRCHPGFDLVGS 415
              C+    +      C+ V C       NG  + I  T    F+++    C  G+ L G 
Sbjct: 2925 RTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTT---FSSSVIYSCMEGYILSGP 2981

Query: 416  SIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA------CDEG 469
            S+  C  NG WSG+   C + +C     P +G        + Y    +V       C  G
Sbjct: 2982 SVRQCTANGTWSGTLPNCTIISCGDPGIPANG--------LRYGDDYVVGQNVSYMCQPG 3033

Query: 470  YRLE--GSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFG---TI 524
            Y +E  GS   TC  N  W G  P C    C T   P  +     N   +   F    +I
Sbjct: 3034 YTMELNGSRIRTCTINGTWSGVMPTCRAVTCPT---PPQI----SNGRLEGTNFDWGFSI 3086

Query: 525  CYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSA 584
             Y+ C  G+ LS    +L C  +G W+  V   + K    P I      E K+   Q   
Sbjct: 3087 SYI-CSPGYELS-FPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEV 3144

Query: 585  NVTWQIP 591
            + +   P
Sbjct: 3145 SFSCNFP 3151



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 69/283 (24%), Positives = 99/283 (34%), Gaps = 58/283 (20%)

Query: 2714 SIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN----RKWSGASPR 2769
            S  C  P  P  G L  T   +G  ++YSC  G+IL G     C+ N      W    P 
Sbjct: 175  SSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 234

Query: 2770 CEAISCKKPNPVMNGSIKGSNYTYLS-------------TLYYECDPG----YVLNGTER 2812
            C A           G+++GS+    S             T     +PG     +    + 
Sbjct: 235  CRA------EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQM 288

Query: 2813 RTCQDDKNWDEDEPICIPVDCSS--PPV-------------SANGQVRG--DEYTFQKEI 2855
                D    +  EP  I +   +  PP+              +N + RG    Y  +K I
Sbjct: 289  EEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAI 348

Query: 2856 EYTCNEGFLL----EGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMK 2911
            ++  + GF L    + +     L  G    A+       C  P +  NG   G D+    
Sbjct: 349  DFK-SRGFKLFPGKDNSNKFSILNEGGIKTASN-----LCPDPGEPENGKRIGSDFSLGS 402

Query: 2912 EVTFHCHEGYILHGAPKLTCQSDGN----WDAEIPLCKPVNCG 2950
             V F C E Y+L GA  +TCQ        W    P+CK   CG
Sbjct: 403  TVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCG 445



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 88/446 (19%), Positives = 142/446 (31%), Gaps = 105/446 (23%)

Query: 2771 EAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTC----QDDKNWDEDEP 2826
            ++ SC  P     G + G+ +     + Y C  GY+L+G  + TC     +  +WD   P
Sbjct: 174  QSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVP 233

Query: 2827 ICIPVD-CSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPD 2885
            IC   D C      ++G +    +  +      C    + E   +   +          D
Sbjct: 234  ICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYD 293

Query: 2886 CVPVRCATPPQL-------------------ANGVTE--------GLDYGFMKEVTFHCH 2918
             + +  + PP +                    + VT+           Y   K + F   
Sbjct: 294  YLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSR 353

Query: 2919 EGYILHG---APKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQC 2975
               +  G   + K +  ++G       LC   + G PE   +G   G  F  G  +Q+ C
Sbjct: 354  GFKLFPGKDNSNKFSILNEGGIKTASNLCP--DPGEPE---NGKRIGSDFSLGSTVQFSC 408

Query: 2976 FPGYKLHGNSSRRCLS----NGSWSGSSPSCLPCRCSTPVI-EYGTVNGTDFDCGKAARI 3030
               Y L G  S  C        +WS   P C    C + +    GT    +F     +  
Sbjct: 409  DEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNA 468

Query: 3031 QC----------------FKGFKL-LGLSEITCEADGQ---------------------- 3051
            QC                F+ F L +G   +T    G+                      
Sbjct: 469  QCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVS 528

Query: 3052 -----W----------SSGF----PHCEHTSCGSLPMIPNAFISETSSW-KENVITYSCR 3091
                 W          S GF       E  SCG  P  P   I E   +   +V+ + C+
Sbjct: 529  MSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGD-PGTPLYGIREGDGFSNRDVLRFECQ 587

Query: 3092 SGYVIQGSSDLICTEKGVWSQPYPVC 3117
             G+ + G   ++C E   WS   P+C
Sbjct: 588  FGFELIGEKSIVCQENNQWSANIPIC 613



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 40/141 (28%), Positives = 55/141 (39%), Gaps = 17/141 (12%)

Query: 438  CPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQ----GNSQWDGPEPRC 493
            C     P HG+I   T   L  +    ACD G+RL G     C+    G   WD P P C
Sbjct: 2465 CSTPESPPHGYIISQTGGQL-NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2523

Query: 494  VERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQGFILSGVKEMLR--CTTSGK 549
                C    +PK    +P N G     +  GT     C  G+ LS  KE+    C + G 
Sbjct: 2524 QAISCG---IPK----APTNGGILTTDYLVGTRVTYFCNDGYRLSS-KELTTAVCQSDGT 2575

Query: 550  WNVGVQAAVCKDVEAPQINCP 570
            W+   +   C  +   ++  P
Sbjct: 2576 WSNHNKTPRCVVISCGELPTP 2596



 Score = 45.8 bits (107), Expect = 8e-04
 Identities = 29/104 (27%), Positives = 43/104 (41%), Gaps = 6/104 (5%)

Query: 395  NNHFNAACG----VRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHIS 450
            NN F    G      C  G  L GS+   CLP+  WSG +  C   +C     P H ++ 
Sbjct: 3195 NNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANV- 3253

Query: 451  CSTREMLYKTTCLVACDEGYRLE-GSDKLTCQGNSQWDGPEPRC 493
                   +  T +  C  G+ L  G++   C+ ++ W G  P C
Sbjct: 3254 VGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3297



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 17/59 (28%), Positives = 28/59 (47%)

Query: 1686 ERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCL 1744
            E+ SCG P     G    D F     + ++C  G+ L+G+  + C +N  W+   P C+
Sbjct: 556  EKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICI 614



 Score = 41.6 bits (96), Expect = 0.014
 Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 2/54 (3%)

Query: 461  TCLVACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCVERHCSTFQMPKDVIISPH 512
            T   +C  GYRLEG+ ++ C G  +  W  P PRCV    ++    + +++SP+
Sbjct: 1099 TLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPN 1152



 Score = 39.3 bits (90), Expect = 0.071
 Identities = 18/47 (38%), Positives = 24/47 (51%), Gaps = 3/47 (6%)

Query: 1647 DLKPGSKVNLFCDPGFQLVGNPVQYCLN--QGQWTQPLPHCERISCG 1691
            D   G  ++  C PG+ L+GN    CL+     W  PLP CE + CG
Sbjct: 2135 DFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-CG 2180



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 16/46 (34%), Positives = 22/46 (47%)

Query: 466 CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
           C  G+ L G   + CQ N+QW    P C+    S F  P   ++SP
Sbjct: 586 CQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSP 631



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 18/52 (34%), Positives = 24/52 (46%)

Query: 460 TTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
           +T   +CD GYRL   + L C+ N  W  P P C        + P   I+SP
Sbjct: 926 STVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSP 977



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 4/99 (4%)

Query: 437  TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGN--SQWDGPEPRCV 494
            +CP  + P  G I    R M+        CD+GY L+G   +TC      +W+ P P C+
Sbjct: 1947 SCPEPQTPSSG-IKIGDRYMVGDVVSF-QCDQGYSLQGHSHITCMPGPVRRWNYPIPICL 2004

Query: 495  ERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGF 533
             +          VI+SP   G  P+       ++   GF
Sbjct: 2005 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGF 2043



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 21/57 (36%), Positives = 26/57 (45%), Gaps = 8/57 (14%)

Query: 2501 PKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCL----ETGDWDVDAPSCNA 2553
            PK +L G    T    G  + YSC  G+ L+G   LTC+     T  WD   P C A
Sbjct: 185  PKGVLYG----TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237



 Score = 37.4 bits (85), Expect = 0.27
 Identities = 24/80 (30%), Positives = 37/80 (46%), Gaps = 7/80 (8%)

Query: 438 CPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQ----WDGPEPRC 493
           CP   +P++G    S  +    +T   +CDE Y L+G+  +TCQ  ++    W    P C
Sbjct: 382 CPDPGEPENGKRIGS--DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 439

Query: 494 VERHC-STFQMPKDVIISPH 512
             + C S  Q P     SP+
Sbjct: 440 KVKTCGSNLQGPSGTFTSPN 459



 Score = 37.4 bits (85), Expect = 0.27
 Identities = 18/59 (30%), Positives = 28/59 (47%), Gaps = 2/59 (3%)

Query: 363  REGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCL 421
            ++G+    Q  +L  CP  +P  NG+ I N             C PG+ L+G+S + CL
Sbjct: 2105 KQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFT--VGQTISFECFPGYTLIGNSALTCL 2161



 Score = 36.2 bits (82), Expect = 0.60
 Identities = 20/65 (30%), Positives = 27/65 (41%), Gaps = 6/65 (9%)

Query: 2556 CDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTC-----EESGWSSSIPTCMP 2610
            C +P     G + G  +  G  I YSC  G+ + GH   TC       + W   +P C  
Sbjct: 178  CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237

Query: 2611 ID-CG 2614
             D CG
Sbjct: 238  EDACG 242



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 18/52 (34%), Positives = 27/52 (51%), Gaps = 4/52 (7%)

Query: 464 VACDEGY-RLEGSDKLTC---QGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
           V C+EG+ + +G++ +TC    G   W G  P+C       F  P  VI+SP
Sbjct: 754 VICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSP 805



 Score = 34.7 bits (78), Expect = 1.7
 Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%)

Query: 364  EGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVR-CHPGFDLVGSSIILCL 421
            EG++    + EL HC     P+ GY I +    HF  +  +  C+PG+ L GSS++ C+
Sbjct: 1236 EGFQLVYTSFELSHCEDPGIPQFGYKISD--QGHFAGSTIIYGCNPGYTLHGSSLLKCM 1292



 Score = 32.7 bits (73), Expect = 6.6
 Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 2/37 (5%)

Query: 460  TTCLVACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCV 494
            +T +  C+ GY L GS  L C    +  WD P P C+
Sbjct: 1271 STIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCI 1307



 Score = 32.3 bits (72), Expect = 8.6
 Identities = 21/53 (39%), Positives = 26/53 (49%), Gaps = 6/53 (11%)

Query: 465 ACDEGYRLEGSDKLTCQGNS----QWDGPEPRC-VERHC-STFQMPKDVIISP 511
           +C  GY L+G  +LTC  NS     WD P P C  E  C  T +    +I SP
Sbjct: 203 SCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSP 255


>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
          Length = 3487

 Score =  445 bits (1144), Expect = e-124
 Identities = 503/2060 (24%), Positives = 779/2060 (37%), Gaps = 347/2060 (16%)

Query: 1651 GSKVNLFCDPGFQLVGNPVQYCLN--QGQWTQPLPHC--------------ERISCGVPP 1694
            GS V+  CDPG+ L G+    CL+  +  W +PLP C              + +S G P 
Sbjct: 1231 GSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECGGTVRGEVSGQVLSPGYPA 1290

Query: 1695 PLENGFHS--ADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVG 1752
            P E+  +     +  AG T+       ++L+ D+         W+G   S + + E +  
Sbjct: 1291 PYEHNLNCIWTIEAEAGCTIGL-----HFLVFDTEEVHDVLRIWDGPVESGVLLKELSGP 1345

Query: 1753 SDCSEHASCLNVDGSYICSCVPPYTGD----------GKNCAEPIKCKAPGNPENGHSSG 1802
            +   +  S  N       S V  ++ D            + +    C  PG P+NG  SG
Sbjct: 1346 ALPKDLHSTFN-------SVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRSG 1398

Query: 1803 EIYTVGAEVTFSCQEGYQLMGVTKITCLESGE---WNHLIPYCKAVSCGKPAIPENGCIE 1859
            + +  G    F C  GY L G  +I+C++      W    P C A  CG      +G I 
Sbjct: 1399 DSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIA-PCGGDLTGPSGVIL 1457

Query: 1860 ELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILS 1919
               +         C+   T++ D   + + N                   N+  G   L 
Sbjct: 1458 SPNYPEPYPPGKECDWKVTVSPDYVIALVFNIF-----------------NLEPGYDFLH 1500

Query: 1920 GLTYLSTASYSCDTGYSLQGPSIIECTASGIW-----DRAPPACHLVF---------CGE 1965
                  + S    + Y  Q P  IE +++ ++     D +      V          C +
Sbjct: 1501 IYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFD 1560

Query: 1966 PPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECL--ADGK--WSRSDQQCLA--- 2018
            P +IK+    G++    ++VTY C  GY + G  T+ C+   DGK  W+     C A   
Sbjct: 1561 PGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCG 1620

Query: 2019 ----------VSCDEPP-------IVDHASPETAHRLFGDIAFYYCS--------DGYS- 2052
                      +S + P         +   +    + +FG  AF++ +        DG+S 
Sbjct: 1621 GQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQ 1680

Query: 2053 ------------------LADNSQLLCNAQGKWVPPEG------QDMPRCIAHFCEKPPS 2088
                              LA ++Q+L     K + P        Q +PR  A  C   P 
Sbjct: 1681 HSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPE 1740

Query: 2089 VSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECM----RGGQWNPSPMSIQCIPV 2144
              Y        + F+ G++V F+C  G+ L  S +IEC+       QWN S  +  C+ V
Sbjct: 1741 PRYG---KRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPT--CV-V 1794

Query: 2145 RCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSC 2204
             CG   +   G      +    + + +C     +        +     +        V  
Sbjct: 1795 PCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFD 1854

Query: 2205 GEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDC 2264
            G    V    L   +G    + +    N  Y    S + V  A  H   ++  +     C
Sbjct: 1855 GADNTVT--MLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLS---SC 1909

Query: 2265 GKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKS--GKWNKKSNPKCMPAK 2322
             +P    NG   GE + V   V F C  GY L G +  +C      +WN    P C+ A+
Sbjct: 1910 PEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPP-PLCI-AQ 1967

Query: 2323 CPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCT 2382
            C           ++E+    GV+      G+    PS + C     W  + PV       
Sbjct: 1968 CGG--------TVEEME---GVILSPGFPGNY---PSNMDC----SWKIALPV------- 2002

Query: 2383 PPPLISFGVPIPSSALHFGSTVKYSCV---GGFF----LRGNSTTLCQPDGTWSSPLPEC 2435
                  FG  I    L+F +   +  +    G +    + G  +    P    S+     
Sbjct: 2003 -----GFGAHI--QFLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETT 2055

Query: 2436 VPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELV----GNTTTLCGENGHWLGGKP 2491
            V       +  P   ++ Q L Y S  + +   GF+L      N+T     +  W    P
Sbjct: 2056 VYFHSDHSQNRPGFKLEYQDLTY-SHQISSFLRGFDLSELERTNSTPPVAASYVW-DLDP 2113

Query: 2492 TCKAI---ECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLE--TGDWDV 2546
             C+A    EC  P+   NG       + GQ+VT+ C  G++L G   LTC      +WD 
Sbjct: 2114 GCEAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDH 2173

Query: 2547 DAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIP 2606
              P C  + C       NG V    YS          PGF     + Q C    W  ++P
Sbjct: 2174 PLPKCE-VPCGGNITSSNGTV----YS----------PGFPSPYSSSQDCV---WLITVP 2215

Query: 2607 T--CMPIDCGLPPHIDFGDCTKLKDDQ-------GYF---------EQEDDMMEVPYVTP 2648
                + ++  L      GD   + D         G F         +   + + + +   
Sbjct: 2216 IGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRD 2275

Query: 2649 HPPYHLGAVA-KTWENTKESP---------ATHSSNFLYGTMVSYTCNPGYELLGNPVLI 2698
                 + A+A   +  TK  P          T +  F  G +V Y C PG+ L+GN +L 
Sbjct: 2276 AATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILT 2335

Query: 2699 CQEDGTW---NGSAPSCISIECDLPT---APENGFLRFTETSMGSAVQYSCKPGHILAGS 2752
            C+  GT+    G  P C   E   PT     ++  +  +++  GS  Q+      +    
Sbjct: 2336 CKL-GTYLQFEGPPPIC---EVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEP 2391

Query: 2753 DLRLCLENRKW---------------SGASPRCEAIS----------------------- 2774
            D  + L    +               SG SP  +A+S                       
Sbjct: 2392 DYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSD 2451

Query: 2775 ----------------CKKPNPVMNGSIKGSNYTYL-STLYYECDPGYVLNGTERRTC-- 2815
                            C  P   ++G I G   T    ++++ C+ GY L G     C  
Sbjct: 2452 HAYNRKGFKIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTR 2511

Query: 2816 --QDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLE-GARSRV 2872
              Q    W E  P+C  + C  P    NG V G EYT   +  Y+C+EG+ L+ GA +  
Sbjct: 2512 HPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATA 2571

Query: 2873 -CLANGSWS--GATPDCVPVRCATPPQLANGVTEG-------LDYGFMKEVTFHCHEGYI 2922
             CL  G WS     P CVPV C  P   +  V  G         Y F  ++   C  GY 
Sbjct: 2572 ECLDTGLWSNRNVPPQCVPVTC--PDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYY 2629

Query: 2923 LHGAPKLTCQSDGNWDA--EIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYK 2980
              G   + CQ++G W      P C+ ++CG      +G   G   ++G    + C  GY 
Sbjct: 2630 YTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYT 2689

Query: 2981 LHGNSSRRCLSNGSWSGSSPSCLPCRCSTP-VIEYGTVNGTDFDCGKAARIQCFKGFKLL 3039
            L G+  R C++NG WSGS   CL   C TP  I  G +NG ++    +   QC  GF+L+
Sbjct: 2690 LVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLI 2749

Query: 3040 GLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGS 3099
            G+S   C+ D  WS   P C   SCG     P++ +S  S     V+ YSC     + G+
Sbjct: 2750 GMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGN 2809

Query: 3100 SDLICTEKGVWSQPYPVCEPLS---CGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDT 3156
            S  +C   G W+   P C   S   CG P   A+ +  G++    + ++  C  G+ +  
Sbjct: 2810 STRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRG 2869

Query: 3157 DTDTFTCQKDGRWFPERISCSPKKCPLPENITHI-LVHGDDFSVNRQVSVSCAEGYTFEG 3215
             ++  TCQ +G W   +  C    C  P   ++  +V  D    +  +   C EGY   G
Sbjct: 2870 SSER-TCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATG 2928

Query: 3216 VNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEG 3275
            +    C ++GTW    SD  C  ++CG P  P +G  +G+ + +  T+ YQC PGY +E 
Sbjct: 2929 LLSRHCSVNGTWTG--SDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMES 2986

Query: 3276 NRERV--CQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEG 3333
            +R  V  C ++R W+G   +CK   C+ P    NGK    +   G +V Y+C  GY L  
Sbjct: 2987 HRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQLSL 3046

Query: 3334 PSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGH 3393
            P+   C  NG+W+  +P C P  C  P V P      ++ F    +VS  C    +L G 
Sbjct: 3047 PAVFTCEGNGSWTGELPQCFPVFCGDPGV-PSRGRREDRGFSYRSSVSFSCHPPLVLVGS 3105

Query: 3394 GIITCNPDETWTQTSAKC---EKISCGPPAHVENAIARGVH-YQYGDMITYSCYSGYMLE 3449
                C  D TW+ T   C      +C  P   +  I      YQ G  + + C  GY+L+
Sbjct: 3106 PRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQ 3165

Query: 3450 GFLRSVCLENGTWT-SPPIC 3468
            G     CL N TW+ +PP C
Sbjct: 3166 GSTTRTCLPNLTWSGTPPDC 3185



 Score =  436 bits (1120), Expect = e-121
 Identities = 339/1216 (27%), Positives = 511/1216 (42%), Gaps = 131/1216 (10%)

Query: 1683 PHCERIS---CGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGV 1739
            P CE      C  P P  NG      +  G +VT++C  GY L G   + C    + N  
Sbjct: 2113 PGCEAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWD 2172

Query: 1740 SPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGH 1799
             P    + +C V   C  + +  N  G+      P      ++C   I            
Sbjct: 2173 HP----LPKCEV--PCGGNITSSN--GTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNL 2224

Query: 1800 S------SGEIYTV--GAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVS----- 1846
            S      SG+  T+  G + T + + G     + K T   S     L  +  A +     
Sbjct: 2225 SLLQTEPSGDFITIWDGPQQT-APRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFA 2283

Query: 1847 ----------CGKPAIPENGCI--EELAFTFGSKVTYRCNKGYTLAGDKESSCLANS--S 1892
                      C  P I  N  +  E   F  G  V YRC  G+TL G++  +C   +   
Sbjct: 2284 IAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQ 2343

Query: 1893 WSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASY----SCDTGYSLQGPSIIECTAS 1948
            +   PP+CE V C + E + +   ++   +Y    SY    +C     ++    I  T  
Sbjct: 2344 FEGPPPICE-VHCPTNELLTDSTGVILSQSY--PGSYPQFQTCSWLVRVEPDYNISLTVE 2400

Query: 1949 GIWDRAPPACHLVF---CGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLA 2005
                        +F    G+ P +K       N++    VT +    Y     D      
Sbjct: 2401 YFLSEKQYDEFEIFDGPSGQSPLLK---ALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRK 2457

Query: 2006 DGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQG 2065
              K   S   C   S    P+      +T+ +  G I F  C+ GY L  +S  +C    
Sbjct: 2458 GFKIRYSAPYC---SLPRAPLHGFILGQTSTQPGGSIHFG-CNAGYRLVGHSMAICTRHP 2513

Query: 2066 KWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKI- 2124
            +      + +P C A  C  P +    +   V   ++  G+   + C EG+ L   A+  
Sbjct: 2514 QGYHLWSEAIPLCQALSCGLPEAPKNGM---VFGKEYTVGTKAMYSCSEGYHLQAGAEAT 2570

Query: 2125 -ECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASG-----SNYSFGAMVAYSCNKGFYI 2178
             EC+  G W+   +  QC+PV C +  SI   +        + Y F A +   C+ G+Y 
Sbjct: 2571 AECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYY 2630

Query: 2179 KGEKKSTCEATGQWS--SPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYK 2236
             G++   C+A G+WS     PTC  +SCGE P   NG    T   ++ +   + CN GY 
Sbjct: 2631 TGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLS-VYGATAIFSCNSGYT 2689

Query: 2237 SVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYEL 2296
             VGS V  C AN  W S S + C+   CG P PI NG + GEN+     V + CN G+ L
Sbjct: 2690 LVGSRVRECMANGLW-SGSEVRCLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRL 2748

Query: 2297 VGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQ 2356
            +G S   CQ+   W+ K+ P C+   C  P    +  +  +  T   VV +SC     L 
Sbjct: 2749 IGMSVRICQQDHHWSGKT-PFCVLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLV 2807

Query: 2357 GPSVLKCLPSQQWNDSFPVCK---IVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFF 2413
            G S   C     W  S P C    + +C  P + + G+ +  S    G+ +++SC  G  
Sbjct: 2808 GNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDS-FDPGTVMRFSCEAGHV 2866

Query: 2414 LRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNG-IIDVQGLAYLSTALYTCKPGFEL 2472
            LRG+S   CQ +G+WS   PEC  + C  P    N  ++   GL + S+ +Y C+ G+  
Sbjct: 2867 LRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYA 2926

Query: 2473 VGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEG 2532
             G  +  C  NG W G  P C  I C  P    NG     D  Y +TVTY C  G+ +E 
Sbjct: 2927 TGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMES 2986

Query: 2533 P--SALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAG 2590
               S L+C +   W+   P C A+ C  P  I NG V G+D+ +G+ + Y+C  G+Q++ 
Sbjct: 2987 HRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQLSL 3046

Query: 2591 HAMQTCEESG-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPH 2649
             A+ TCE +G W+  +P C P+ CG P     G     ++D+G                 
Sbjct: 3047 PAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRG----RREDRG----------------- 3085

Query: 2650 PPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSA 2709
                                     F Y + VS++C+P   L+G+P   CQ DGTW+G+ 
Sbjct: 3086 -------------------------FSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQ 3120

Query: 2710 PSCIS---IECDLPTAPENGFLRFTE-TSMGSAVQYSCKPGHILAGSDLRLCLENRKWSG 2765
            PSCI      C  P  P+ G    ++   +GS V + C+ G++L GS  R CL N  WSG
Sbjct: 3121 PSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSG 3180

Query: 2766 ASPRCEAISCKKPNPVMNGSIKGSNYTYLS-TLYYECDPGYVL-NGTERRTCQDDKNWDE 2823
              P C    C++P    + ++   +   +  TL Y C  G+ L  G+E RTC+ D +W  
Sbjct: 3181 TPPDCVPHHCRQPETPTHANVGALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTG 3240

Query: 2824 DEPICIPVDCSSPPVS 2839
              PIC+ V  S  P++
Sbjct: 3241 KPPICLEVRPSGRPIN 3256



 Score =  411 bits (1056), Expect = e-114
 Identities = 421/1801 (23%), Positives = 654/1801 (36%), Gaps = 322/1801 (17%)

Query: 1636 GSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCL----NQGQWTQPLPHCERISCG 1691
            GS+ +      DLK GS V  +C  G+++ G     C+     +  W  P P C    CG
Sbjct: 1562 GSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTA-PCG 1620

Query: 1692 VPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAV 1751
                  +G   + ++    T    C     +  D  +F    G +     +  DV E   
Sbjct: 1621 GQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVF----GQFAFFHTALNDVVEVHD 1676

Query: 1752 GSDCSEHASCLN-VDGSYICSCVPPYTGD-------GKNCA---------------EPIK 1788
            G   S+H+  L+ + GS+    +P  T +        K  A                  +
Sbjct: 1677 GH--SQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQ 1734

Query: 1789 CKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLES----GEWNHLIPYCKA 1844
            C +   P  G   G  ++VGA V F C  GY L G  +I CL       +WN   P C  
Sbjct: 1735 CSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTC-V 1793

Query: 1845 VSCG-----------KPAIPEN-----GCIEELAFTFGSKVTYRCNKGYTL--------- 1879
            V CG            P  PE       C+ ++    G+ +  +     T          
Sbjct: 1794 VPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVF 1853

Query: 1880 -AGDKESSCLANSSWSHSPPVCEPVK-----------------------------CSSPE 1909
               D   + L + S +  P +                                  C  P 
Sbjct: 1854 DGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPA 1913

Query: 1910 NINNGKYILSGLTYL--STASYSCDTGYSLQGPSIIECTASGI--WDRAPPACHLVFCGE 1965
              +NG  + +G  YL     S+ C+ GY+LQG + I C    +  W+  PP C +  CG 
Sbjct: 1914 VPSNG--VKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLC-IAQCGG 1970

Query: 1966 PPAIKDAVITGNNFTFRNTVTYTCKEGYTLA----------------GLDTIECLAD--- 2006
                 + VI    F         C     L                   D IE       
Sbjct: 1971 TVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYE 2030

Query: 2007 -----GKWSRSDQQCLAVSCDEPPIV----DHASPETAHRL-FGDIAFYYCSDGYSLA-D 2055
                 G++S S+     +S      V    DH+      +L + D+ + +    +    D
Sbjct: 2031 TSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQISSFLRGFD 2090

Query: 2056 NSQLLCNAQGKWVPPEGQDM-----PRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSF 2110
             S+L    +    PP          P C A+  ++ P         V  A +  G  V+F
Sbjct: 2091 LSEL---ERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRGAGYNVGQSVTF 2147

Query: 2111 KCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAY 2170
            +C+ G+ L     + C  G   N      +C  V CG   +  NG      YS G    Y
Sbjct: 2148 ECLPGYQLTGHPVLTCQHGTNRNWDHPLPKC-EVPCGGNITSSNGTV----YSPGFPSPY 2202

Query: 2171 SCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCG------EPPKVENGFLEHTTGRIFE 2224
            S ++                 W   +P  H V         EP      F+    G    
Sbjct: 2203 SSSQDCV--------------WLITVPIGHGVRLNLSLLQTEP---SGDFITIWDG---P 2242

Query: 2225 SEVRYQCNPGYKSVGSPVFVCQANR---HWHSESP--------LMCVPLDCGKPP---PI 2270
             +   +     +S+        +N+    +H ++             PL    PP   P 
Sbjct: 2243 QQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPN 2302

Query: 2271 QNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLE 2330
                 + E F +G  V++ C  G+ LVG+   TC+       +  P      CP   LL 
Sbjct: 2303 AEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLT 2362

Query: 2331 NQ--LVLKE-------------------------LTTEVGVVTFSCKEGHVLQGPS---- 2359
            +   ++L +                         LT E  +      E  +  GPS    
Sbjct: 2363 DSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSP 2422

Query: 2360 VLKCLPSQ----------------QWNDSFPVCK--------IVLCTPPPLISFGVPIPS 2395
            +LK L                   +W+      +           C+ P     G  +  
Sbjct: 2423 LLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPRAPLHGFILGQ 2482

Query: 2396 SALHFGSTVKYSCVGGFFLRGNSTTLC--QPDG--TWSSPLPECVPVECPQPEEIPNGII 2451
            ++   G ++ + C  G+ L G+S  +C   P G   WS  +P C  + C  PE   NG++
Sbjct: 2483 TSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMV 2542

Query: 2452 DVQGLAYLSTALYTCKPGFELVGNT--TTLCGENGHWLGGK--PTCKAIEC--LKPKEIL 2505
              +     + A+Y+C  G+ L      T  C + G W      P C  + C  +    + 
Sbjct: 2543 FGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVE 2602

Query: 2506 NGKFSY---TDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDV--DAPSCNAIHCDSPQ 2560
            +G++     T   +   +   C+ G+   G   + C   G W +    P+C  I C    
Sbjct: 2603 HGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELP 2662

Query: 2561 PIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPTCMPIDCGLPPHI 2619
               NG   G    YGA  I+SC  G+ + G  ++ C  +G WS S   C+   CG P   
Sbjct: 2663 IPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPE-- 2720

Query: 2620 DFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGT 2679
                                    P V  H                     +  N+ Y  
Sbjct: 2721 ------------------------PIVNGH--------------------INGENYSYRG 2736

Query: 2680 MVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAV 2739
             V Y CN G+ L+G  V ICQ+D  W+G  P C+ + C  P +P +  +     ++G+ V
Sbjct: 2737 SVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGDSYTVGAVV 2796

Query: 2740 QYSCKPGHILAGSDLRLCLENRKWSGASPRCEAIS---CKKPNPVMNGSIKGSNYTYLST 2796
            +YSC     L G+  R+C  +  W+G+ P C   S   C  P    +G   G ++   + 
Sbjct: 2797 RYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTV 2856

Query: 2797 LYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQ-VRGDEYTFQKEI 2855
            + + C+ G+VL G+  RTCQ + +W   +P C  + C +P   +N + V  D   F   I
Sbjct: 2857 MRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSI 2916

Query: 2856 EYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTF 2915
             Y C EG+   G  SR C  NG+W+G+ P+C+ + C  P   ANG+  G D+ + K VT+
Sbjct: 2917 VYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTY 2976

Query: 2916 HCHEGYIL--HGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQY 2973
             C  GY++  H    L+C  D  W+   P+CK + C PP  + +G   G  F+ G  + Y
Sbjct: 2977 QCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTY 3036

Query: 2974 QCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTP-VIEYGTVNGTDFDCGKAARIQC 3032
             C  GY+L   +   C  NGSW+G  P C P  C  P V   G      F    +    C
Sbjct: 3037 ACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSYRSSVSFSC 3096

Query: 3033 FKGFKLLGLSEITCEADGQWSSGFPHC---EHTSCGSLPMIPNAFISETSSWKE--NVIT 3087
                 L+G     C++DG WS   P C     T+C   P +P   I   S   +  + + 
Sbjct: 3097 HPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCAD-PGVPQFGIQNNSQGYQVGSTVL 3155

Query: 3088 YSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANA-VATGEAHTYESEVKL 3146
            + C+ GY++QGS+   C     WS   P C P  C  P +  +A V   +  +    +  
Sbjct: 3156 FRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYTLIY 3215

Query: 3147 RCLEGYTMDTDTDTFTCQKDGRW-------FPERISCSPKKCPLPENITHILVHGDDFSV 3199
             C EG+++   ++  TC+ DG W          R S  P        +T  L+ GD F+ 
Sbjct: 3216 SCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPSGRPINTAREPPLTQALIPGDVFAK 3275

Query: 3200 N 3200
            N
Sbjct: 3276 N 3276



 Score =  395 bits (1016), Expect = e-109
 Identities = 363/1367 (26%), Positives = 544/1367 (39%), Gaps = 124/1367 (9%)

Query: 2203 SCGEPPKVENGFLEHTTGR--IFESEVRYQCNPGYKSVGSPVFVCQAN--RHWHSESPLM 2258
            SC EP    NG     TG   +    V +QC PGY   G     C     R W+   PL 
Sbjct: 1908 SCPEPAVPSNGV---KTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPL- 1963

Query: 2259 CVPLDCGKPPPIQNGFMKGENFE------------------VGSKVQFFC-----NEGYE 2295
            C+   CG       G +    F                    G+ +QF       N  Y 
Sbjct: 1964 CIA-QCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYI 2022

Query: 2296 LVGDSSW-TCQKSGKWNKKSNPKCMPAKCPEPPLL---ENQLVLKELTTEVGVVTFSCKE 2351
             + +  + T +  G+++    P  + +   E  +    ++         E   +T+S + 
Sbjct: 2023 EIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQI 2082

Query: 2352 GHVLQG---------PSVLKCLPSQQWNDSFPVCK---IVLCTPPPLISFGVPIPSSALH 2399
               L+G          S      S  W D  P C+   +  C  P   + G+ +  +  +
Sbjct: 2083 SSFLRGFDLSELERTNSTPPVAASYVW-DLDPGCEAYELQECPDPEPFANGI-VRGAGYN 2140

Query: 2400 FGSTVKYSCVGGFFLRGNSTTLCQ--PDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLA 2457
             G +V + C+ G+ L G+    CQ   +  W  PLP+C  V C       NG +   G  
Sbjct: 2141 VGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKC-EVPCGGNITSSNGTVYSPGFP 2199

Query: 2458 YLSTALYTCKPGFEL-VGNTTTLCGENGHWLGGKPTCKAIECLK-PKEILNGKFSYTDLH 2515
               ++   C     + +G+   L   N   L  +P+   I     P++       +T   
Sbjct: 2200 SPYSSSQDCVWLITVPIGHGVRL---NLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSM 2256

Query: 2516 YGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFV--EGADYS 2573
              +TV  S N+        A T    G + +   +     C  P  + N  V  E  +++
Sbjct: 2257 AKKTVQSSSNQVLLKFHRDAAT---GGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFN 2313

Query: 2574 YGAIIIYSCFPGFQVAGHAMQTCEESGWSS--SIPTCMPIDCGLPPHIDFGDCTKLKDDQ 2631
             G I+ Y C PGF + G+ + TC+   +      P    + C  P +    D T +   Q
Sbjct: 2314 IGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHC--PTNELLTDSTGVILSQ 2371

Query: 2632 GYFEQEDDMMEVPY-VTPHPPYHLGAVAKTWENTKE-------------SPATH--SSNF 2675
             Y           + V   P Y++    + + + K+             SP     S N+
Sbjct: 2372 SYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNY 2431

Query: 2676 LYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGF-LRFTETS 2734
                +V+ + N  Y    +     ++      SAP C      LP AP +GF L  T T 
Sbjct: 2432 SAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYC-----SLPRAPLHGFILGQTSTQ 2486

Query: 2735 MGSAVQYSCKPGHILAGSDLRLCLENRK----WSGASPRCEAISCKKPNPVMNGSIKGSN 2790
             G ++ + C  G+ L G  + +C  + +    WS A P C+A+SC  P    NG + G  
Sbjct: 2487 PGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGKE 2546

Query: 2791 YTYLSTLYYECDPGYVLNGTERRT--CQDDKNWDEDE--PICIPVDCSSPPVSANGQVRG 2846
            YT  +   Y C  GY L      T  C D   W      P C+PV C  P VS+     G
Sbjct: 2547 YTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTC--PDVSSISVEHG 2604

Query: 2847 -------DEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWS--GATPDCVPVRCATPPQL 2897
                    +Y FQ ++   C+ G+   G R   C ANG WS   +TP C  + C   P  
Sbjct: 2605 RWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIP 2664

Query: 2898 ANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAH 2957
             NG   G    +     F C+ GY L G+    C ++G W      C   +CG PE + +
Sbjct: 2665 PNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVN 2724

Query: 2958 GFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIE-YGT 3016
            G  NG ++ + G + YQC  G++L G S R C  +  WSG +P C+   C  P    +  
Sbjct: 2725 GHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQ 2784

Query: 3017 VNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSL--PMIPNAF 3074
            ++G  +  G   R  C     L+G S   C  DG W+   PHC  TS G    P IP   
Sbjct: 2785 MSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHG 2844

Query: 3075 ISETSSWKEN-VITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANA-V 3132
            I    S+    V+ +SC +G+V++GSS+  C   G WS   P C  +SCG+P + +NA V
Sbjct: 2845 IRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARV 2904

Query: 3133 ATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILV 3192
               +   + S +   C EGY   T   +  C  +G W      C    C  P    + L 
Sbjct: 2905 VFSDGLVFSSSIVYECREGYYA-TGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLR 2963

Query: 3193 HGDDFSVNRQVSVSCAEGYTFEGVNISV--CQLDGTWEPPFSDESCSPVSCGKPESPEHG 3250
             G+DF  N+ V+  C  GY  E   +SV  C  D TW    +   C  + C  P    +G
Sbjct: 2964 LGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNG--TKPVCKALMCKPPPLIPNG 3021

Query: 3251 FVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKA 3310
             VVGS + + S++ Y C  GY+L       C+ N  W+G +  C    C  P     G+ 
Sbjct: 3022 KVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRR 3081

Query: 3311 DIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLC---KPNPCPVPFVIPENA 3367
            +    +   +V +SC+    L G     C  +GTWS   P C       C  P V     
Sbjct: 3082 EDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGI 3141

Query: 3368 LLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIA 3427
              + + + V   V  +C++G+LLQG    TC P+ TW+ T   C    C  P    +A  
Sbjct: 3142 QNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANV 3201

Query: 3428 RGVHY-QYGDMITYSCYSGYMLE-GFLRSVCLENGTWT-SPPICRAV 3471
              +     G  + YSC  G+ L+ G     C  +G+WT  PPIC  V
Sbjct: 3202 GALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEV 3248



 Score =  392 bits (1007), Expect = e-108
 Identities = 284/1013 (28%), Positives = 422/1013 (41%), Gaps = 92/1013 (9%)

Query: 2322 KCPEPPLLEN-QLVLKELTTEVG-VVTFSCKEGHVLQGPSVLKCLPSQ--QWNDSFPVCK 2377
            KCP P +L N ++V +     +G +V + C  G  L G  +L C      Q+    P+C+
Sbjct: 2293 KCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICE 2352

Query: 2378 IVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVP 2437
             V C    L++    +  S  + GS  ++                +PD   S  +   + 
Sbjct: 2353 -VHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWL-------VRVEPDYNISLTVEYFLS 2404

Query: 2438 VECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWL---GGKPTCK 2494
             +     EI +G      L    +  Y+         N+  L   + H     G K    
Sbjct: 2405 EKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYS 2464

Query: 2495 AIECLKPKEILNGKF-SYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGD----WDVDAP 2549
            A  C  P+  L+G     T    G ++ + CN G+RL G S   C         W    P
Sbjct: 2465 APYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIP 2524

Query: 2550 SCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGF--QVAGHAMQTCEESG-WSSSI- 2605
             C A+ C  P+  +NG V G +Y+ G   +YSC  G+  Q    A   C ++G WS+   
Sbjct: 2525 LCQALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNV 2584

Query: 2606 -PTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENT 2664
             P C+P+ C         D + +  + G                            W   
Sbjct: 2585 PPQCVPVTCP--------DVSSISVEHG---------------------------RWRLI 2609

Query: 2665 KESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWN--GSAPSCISIECDLPTA 2722
             E+       + +   +   C+PGY   G  V+ CQ +G W+   S P+C  I C     
Sbjct: 2610 FET------QYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPI 2663

Query: 2723 PENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVM 2782
            P NG    T +  G+   +SC  G+ L GS +R C+ N  WSG+  RC A  C  P P++
Sbjct: 2664 PPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIV 2723

Query: 2783 NGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANG 2842
            NG I G NY+Y  ++ Y+C+ G+ L G   R CQ D +W    P C+ V C  P    + 
Sbjct: 2724 NGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHS 2783

Query: 2843 QVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVR---CATPPQLAN 2899
            Q+ GD YT    + Y+C     L G  +R+C  +G W+G+ P C       C  P   A+
Sbjct: 2784 QMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAH 2843

Query: 2900 GVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHG- 2958
            G+  G  +     + F C  G++L G+ + TCQ++G+W    P C  ++CG P   ++  
Sbjct: 2844 GIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNAR 2903

Query: 2959 --FPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVI-EYG 3015
              F +G  F     I Y+C  GY   G  SR C  NG+W+GS P CL   C  P I   G
Sbjct: 2904 VVFSDGLVF--SSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANG 2961

Query: 3016 TVNGTDFDCGKAARIQCFKGFKLLG--LSEITCEADGQWSSGFPHCEHTSCGSLPMIPNA 3073
               G DF   K    QC  G+ +    +S ++C  D  W+   P C+   C   P+IPN 
Sbjct: 2962 LRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNG 3021

Query: 3074 FISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVA 3133
             +  +     + +TY+C  GY +   +   C   G W+   P C P+ CG P   +    
Sbjct: 3022 KVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRR 3081

Query: 3134 TGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISC---SPKKCPLPENITH- 3189
                 +Y S V   C     +      F CQ DG W   + SC   +   C  P      
Sbjct: 3082 EDRGFSYRSSVSFSCHPPLVLVGSPRRF-CQSDGTWSGTQPSCIDPTLTTCADPGVPQFG 3140

Query: 3190 ILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWE--PPFSDESCSPVSCGKPESP 3247
            I  +   + V   V   C +GY  +G     C  + TW   PP     C P  C +PE+P
Sbjct: 3141 IQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPP----DCVPHHCRQPETP 3196

Query: 3248 EHGFVVGSKY-TFESTIIYQCEPGYELEGNRE-RVCQENRQWSGGVAICKETR 3298
             H  V      +   T+IY C+ G+ L+G  E R C+ +  W+G   IC E R
Sbjct: 3197 THANVGALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVR 3249



 Score =  292 bits (748), Expect = 4e-78
 Identities = 190/669 (28%), Positives = 283/669 (42%), Gaps = 45/669 (6%)

Query: 1652 SKVNLFCDPGFQLVGNPVQYCLNQGQWT--QPLPHCERISCGVPPPLENGFHSADDFYAG 1709
            +++ L CDPG+   G  V  C   G+W+     P C  ISCG  P   NG         G
Sbjct: 2618 AQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYG 2677

Query: 1710 STVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAV----------GSDCSEHA 1759
            +T  + CN+GY L+G     C  NG W+G    CL    C            G + S   
Sbjct: 2678 ATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCL-AGHCGTPEPIVNGHINGENYSYRG 2736

Query: 1760 SCL-------NVDGSYICSCVPPYTGDGKN-CAEPIKCKAPGNPENGHSSGEIYTVGAEV 1811
            S +        + G  +  C   +   GK      + C  PG+P +   SG+ YTVGA V
Sbjct: 2737 SVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGDSYTVGAVV 2796

Query: 1812 TFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVS---CGKPAIPENGCIEELAFTFGSK 1868
             +SC     L+G +   C   G W   +P+C   S   CG P IP +G     +F  G+ 
Sbjct: 2797 RYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTV 2856

Query: 1869 VTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILS-GLTYLSTA 1927
            + + C  G+ L G  E +C AN SWS S P C  + C +P   +N + + S GL + S+ 
Sbjct: 2857 MRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSI 2916

Query: 1928 SYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTY 1987
             Y C  GY   G     C+ +G W  + P C ++ CG+P    + +  GN+F +  TVTY
Sbjct: 2917 VYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTY 2976

Query: 1988 TCKEGYTLAG--LDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFY 2045
             C  GY +    +  + C  D  W+ +   C A+ C  PP++ +     +  ++G    Y
Sbjct: 2977 QCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTY 3036

Query: 2046 YCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAG 2105
             C +GY L+  +   C   G W      ++P+C   FC  P   S    E      F+  
Sbjct: 3037 ACLEGYQLSLPAVFTCEGNGSWT----GELPQCFPVFCGDPGVPSRGRRED---RGFSYR 3089

Query: 2106 SVVSFKCMEGFVLNTSAKIECMRGGQWN-PSPMSIQCIPVRCGEPPSIMNGYASGS-NYS 2163
            S VSF C    VL  S +  C   G W+   P  I      C +P     G  + S  Y 
Sbjct: 3090 SSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQ 3149

Query: 2164 FGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIF 2223
             G+ V + C KG+ ++G    TC     WS   P C P  C +P    +  +        
Sbjct: 3150 VGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSM 3209

Query: 2224 ESEVRYQCNPGYK-SVGSPVFVCQANRHWHSESPLMCV-------PLDCGKPPPIQNGFM 2275
               + Y C  G+    GS    C+A+  W  + P+ C+       P++  + PP+    +
Sbjct: 3210 GYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPI-CLEVRPSGRPINTAREPPLTQALI 3268

Query: 2276 KGENFEVGS 2284
             G+ F   S
Sbjct: 3269 PGDVFAKNS 3277



 Score =  236 bits (603), Expect = 2e-61
 Identities = 299/1257 (23%), Positives = 462/1257 (36%), Gaps = 235/1257 (18%)

Query: 2344 VVTFSCKEGHVLQGPSVLKCLPSQ----QWNDSFPVCKIVLCTPPPLISFGVPIPSSALH 2399
            +V F C  G+ LQG   ++CLP      QWN S P C +V C                  
Sbjct: 1756 IVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTC-VVPC------------------ 1796

Query: 2400 FGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGI-IDVQGLAY 2458
                      GG       T L         P P    + C     +P G  I +Q +++
Sbjct: 1797 ----------GGNLTERRGTILSP-----GFPEPYLNSLNCVWKIVVPEGAGIQIQVVSF 1841

Query: 2459 LSTALYTCKPGFELVGNTTTLCGE-----------------------------NGHWLGG 2489
            ++   +     F+   NT T+ G                               G  L  
Sbjct: 1842 VTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEY 1901

Query: 2490 KPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLE--TGDWDVD 2547
            K T     C +P    NG  +         V++ C  G+ L+G + ++C+      W+  
Sbjct: 1902 K-TVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYP 1960

Query: 2548 APSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPT 2607
             P C A  C        G VE  +     +I+   FPG   +        +  W  ++P 
Sbjct: 1961 PPLCIA-QC-------GGTVEEME----GVILSPGFPGNYPSNM------DCSWKIALPV 2002

Query: 2608 CMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEV---PYVTPHPPYHLGA-------V 2657
                  G   HI F + +         E   D +E+   PY T                +
Sbjct: 2003 ------GFGAHIQFLNFST--------EPNHDYIEIRNGPYETSRMMGRFSGSELPSSLL 2048

Query: 2658 AKTWENTKESPATHSSN----------FLYGTMVSYTCNPGYELLG----NPVLICQEDG 2703
            + + E T    + HS N            Y   +S     G++L      N         
Sbjct: 2049 STSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQISSFLR-GFDLSELERTNSTPPVAASY 2107

Query: 2704 TWNGSAPSCISIE---CDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLE- 2759
             W+   P C + E   C  P    NG +R    ++G +V + C PG+ L G  +  C   
Sbjct: 2108 VWDLD-PGCEAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHG 2166

Query: 2760 -NRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDD 2818
             NR W    P+CE + C        G+I  SN T  S       PG+    +  + C   
Sbjct: 2167 TNRNWDHPLPKCE-VPC-------GGNITSSNGTVYS-------PGFPSPYSSSQDCV-- 2209

Query: 2819 KNWDEDEPIC--IPVDCSSPPVSANGQV----RGDEYTFQKEIEYTCNEGF-LLEGARSR 2871
              W    PI   + ++ S      +G       G + T  +   +T +     ++ + ++
Sbjct: 2210 --WLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQ 2267

Query: 2872 VCL------ANGSWSGATPDCVPVRCATPPQL---ANGVTEGLDYGFMKEVTFHCHEGYI 2922
            V L      A G          P+    PP +   A  VTE  ++     V + C  G+ 
Sbjct: 2268 VLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFT 2327

Query: 2923 LHGAPKLTCQSDG--NWDAEIPLCKPVNCGPPE--------DLAHGFPNGFSFIHGGHIQ 2972
            L G   LTC+      ++   P+C+ V+C   E         L+  +P  +         
Sbjct: 2328 LVGNEILTCKLGTYLQFEGPPPICE-VHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWL 2386

Query: 2973 YQCFPGYKLHGNSSRRCLSNGSW---------SGSSP--SCLPCRCSTPVIEYGTVNGTD 3021
             +  P Y +   +    LS   +         SG SP    L    S P+I   + N   
Sbjct: 2387 VRVEPDYNI-SLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSV- 2444

Query: 3022 FDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIP--NAFISETS 3079
            +    +      KGFK+            ++S+  P+C      SLP  P     + +TS
Sbjct: 2445 YLRWSSDHAYNRKGFKI------------RYSA--PYC------SLPRAPLHGFILGQTS 2484

Query: 3080 SWKENVITYSCRSGYVIQGSSDLICTEKG----VWSQPYPVCEPLSCGSPPSVANAVATG 3135
            +     I + C +GY + G S  ICT       +WS+  P+C+ LSCG P +  N +  G
Sbjct: 2485 TQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFG 2544

Query: 3136 EAHTYESEVKLRCLEGYTMDTDTD-TFTCQKDGRWFPERI--SCSPKKCPLPENIT---- 3188
            + +T  ++    C EGY +    + T  C   G W    +   C P  CP   +I+    
Sbjct: 2545 KEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHG 2604

Query: 3189 -HILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESP 3247
               L+    +    Q+ + C  GY + G  +  CQ +G W    S  +C  +SCG+   P
Sbjct: 2605 RWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIP 2664

Query: 3248 EHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLN 3307
             +G  +G+   + +T I+ C  GY L G+R R C  N  WSG    C    C TP   +N
Sbjct: 2665 PNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVN 2724

Query: 3308 GKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENA 3367
            G  + EN +   +VVY CN G+ L G S   C ++  WS   P C    C  P   P ++
Sbjct: 2725 GHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHP-GSPPHS 2783

Query: 3368 LLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKIS---CGPPAHVEN 3424
             +S   + V   V   C     L G+    C  D  WT +   C   S   CG P    +
Sbjct: 2784 QMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAH 2843

Query: 3425 AIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWT-SPPICRAVCRFPCQNGG 3480
             I  G  +  G ++ +SC +G++L G     C  NG+W+ S P C  +    C N G
Sbjct: 2844 GIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVI---SCGNPG 2897



 Score =  235 bits (599), Expect = 7e-61
 Identities = 176/621 (28%), Positives = 255/621 (41%), Gaps = 45/621 (7%)

Query: 2949 CGPPEDLAHGFPNGFSFIH-GGHIQYQCFPGYKLHGNSSRRCLSNGS----WSGSSPSCL 3003
            C  P    HGF  G +    GG I + C  GY+L G+S   C  +      WS + P C 
Sbjct: 2468 CSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQ 2527

Query: 3004 PCRCSTPVI-EYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEA--DGQWSSGF--PH 3058
               C  P   + G V G ++  G  A   C +G+ L   +E T E    G WS+    P 
Sbjct: 2528 ALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQ 2587

Query: 3059 CEHTSCGSLPMIPNA-----FISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWS-- 3111
            C   +C  +  I         I ET    +  +   C  GY   G   + C   G WS  
Sbjct: 2588 CVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLG 2647

Query: 3112 QPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFP 3171
               P C  +SCG  P   N    G    Y +     C  GYT+   +    C  +G W  
Sbjct: 2648 DSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTL-VGSRVRECMANGLWSG 2706

Query: 3172 ERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTW--EP 3229
              + C    C  PE I +  ++G+++S    V   C  G+   G+++ +CQ D  W  + 
Sbjct: 2707 SEVRCLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKT 2766

Query: 3230 PFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSG 3289
            PF    C  VSCG P SP H  + G  YT  + + Y C     L GN  R+C  +  W+G
Sbjct: 2767 PF----CVLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTG 2822

Query: 3290 GVAICKETR---CETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWS 3346
             +  C  T    C  P    +G    ++   G  + +SC  G+ L G SE  C  NG+WS
Sbjct: 2823 SLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWS 2882

Query: 3347 HPVPLCKPNPCPVPFVIPENALLSEKEFYV-DQNVSIKCREGFLLQGHGIITCNPDETWT 3405
               P C    C  P   P NA +   +  V   ++  +CREG+   G     C+ + TWT
Sbjct: 2883 GSQPECGVISCGNPGT-PSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWT 2941

Query: 3406 QTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSV--CLENGTWT 3463
             +  +C  I+CG P    N +  G  ++Y   +TY C  GYM+E    SV  C ++ TW 
Sbjct: 2942 GSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWN 3001

Query: 3464 -SPPICRAVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAP--YQC 3520
             + P+C+A+    C+   +            W   +         CL G +   P  + C
Sbjct: 3002 GTKPVCKALM---CKPPPLIPNGKVVGSDFMWGSSV------TYACLEGYQLSLPAVFTC 3052

Query: 3521 DCPPGWTGS--RCHTAVCQSP 3539
            +    WTG   +C    C  P
Sbjct: 3053 EGNGSWTGELPQCFPVFCGDP 3073



 Score =  130 bits (328), Expect = 2e-29
 Identities = 85/286 (29%), Positives = 122/286 (42%), Gaps = 45/286 (15%)

Query: 1624 KSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLP 1683
            K++ C   P     +P+ +    D   GS V   C  G+QL    V  C   G WT  LP
Sbjct: 3008 KALMCKPPPL----IPNGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELP 3063

Query: 1684 HCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSC 1743
             C  + CG P     G      F   S+V++ C+    L+G  R FC  +G+W+G  PSC
Sbjct: 3064 QCFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSC 3123

Query: 1744 LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENG-HSSG 1802
            +D                            P  T           C  PG P+ G  ++ 
Sbjct: 3124 ID----------------------------PTLT----------TCADPGVPQFGIQNNS 3145

Query: 1803 EIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELA 1862
            + Y VG+ V F CQ+GY L G T  TCL +  W+   P C    C +P  P +  +  L 
Sbjct: 3146 QGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALD 3205

Query: 1863 F-TFGSKVTYRCNKGYTLAGDKE-SSCLANSSWSHSPPVCEPVKCS 1906
              + G  + Y C +G++L G  E  +C A+ SW+  PP+C  V+ S
Sbjct: 3206 LPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPS 3251



 Score =  122 bits (307), Expect = 5e-27
 Identities = 287/1400 (20%), Positives = 457/1400 (32%), Gaps = 367/1400 (26%)

Query: 2146 CGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEA----TGQWSSPIPTCH- 2200
            CG P  + NG   GS ++ G  V YSCN GF+++G    TC A    +  W  P+P+C  
Sbjct: 139  CGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRA 198

Query: 2201 PVSCGEPPKVENGF-----------------------LEHTTGRIFESEVRYQCNPGYKS 2237
              +CG   + ++G                        L  T   +F   + +Q   GY  
Sbjct: 199  DDACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVF---IDFQLEDGYDF 255

Query: 2238 VGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELV 2297
            +   V   + +  W + + L         P P+    +  +N+    ++ F  +  +   
Sbjct: 256  L--EVTGTEGSSLWFTGASL---------PAPV----ISSKNW---LRLHFTSDGNHRQR 297

Query: 2298 GDSSWTCQKSGKWNKKSNPKCMPAK--------------------CPEPPLLENQLVLKE 2337
            G S+    K     K    K MP+K                    CP+P + E    L  
Sbjct: 298  GFSAQYQVKKQIELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGS 357

Query: 2338 LTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQ----WNDSFPVCKIVLCT-----PPPLI- 2387
                   V F+C EG+ LQG   + C+        W+D  PVC+  +C      P  +I 
Sbjct: 358  DFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIIT 417

Query: 2388 SFGVPIP----------SSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVP 2437
            S   PI            +AL+    +K +    F L     TL   DG         + 
Sbjct: 418  SPNFPIQYDNNAHCVWIITALNPSKVIKLA-FEEFDLERGYDTLTVGDGGQDGDQKTVLY 476

Query: 2438 VECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIE 2497
            +       +P+ I+      +L          F+  G        +G  LG K + + IE
Sbjct: 477  I--LTGTSVPDLIVSTNHQMWLL---------FQTDG--------SGSSLGFKASYEEIE 517

Query: 2498 ---CLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAI 2554
               C  P     G+   +  H+G T+ + C   F L G  A+TC +   W    P C   
Sbjct: 518  QGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGC--- 574

Query: 2555 HCDSPQPIENGFVEGADYSYGAIIIYSCFPGF-QVAGHAMQTCEESGWSSSIPTCMPIDC 2613
                                    ++SCF  F   +G  +       + + +  C+ +  
Sbjct: 575  ------------------------VFSCFFNFTSPSGVVLSPNYPEDYGNHL-HCVWLIL 609

Query: 2614 GLPP---HIDFGDCTKLKDDQGYFEQEDDMMEVPYV-------TPHPPYHLGAVAKTWEN 2663
              P    H+ F D            ++    E P +        P      G VA+    
Sbjct: 610  ARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQ 669

Query: 2664 TKESPATHSSNFLYGTMVSYTC-NPGYEL----------LGNPV-LICQED--GTWNGSA 2709
            T  S      N  + T     C +PG  +          LG+ +  +C E   GT     
Sbjct: 670  TDHSTGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSET 729

Query: 2710 PSCI-----------SIECDLP-----TAPEN-----GFLRFTETSMGSAVQYSCKPGHI 2748
             +C+            + C+ P     T+P       G+  F + ++  A     +PG+ 
Sbjct: 730  ITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYP 789

Query: 2749 LAGSDLRL-------CLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYL--STLYY 2799
            +  +  R         LE R   G +     I       V    I  SNY YL  ST   
Sbjct: 790  IKITFDRFKTEVNYDTLEVR--DGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKS 847

Query: 2800 ECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTC 2859
              D G+ L   E  T Q D              C  P +  NGQ  G+++     + ++C
Sbjct: 848  HSDIGFQLR-YETITLQSD-------------HCLDPGIPVNGQRHGNDFYVGALVTFSC 893

Query: 2860 NEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGV----------------TE 2903
            + G+ L       C  N  WS A P C  + C    Q ++G                 T 
Sbjct: 894  DSGYTLSDGEPLECEPNFQWSRALPSCEAL-CGGFIQGSSGTILSPGFPDFYPNNLNCTW 952

Query: 2904 GLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEI------PLCKPVNCG------- 2950
             ++    K V F  H  ++  G   L    +G++   +       L  P++ G       
Sbjct: 953  IIETSHGKGVFFTFHTFHLESGHDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTA 1012

Query: 2951 ----------------------------PPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLH 2982
                                         PE  A+    G  F  G  + + CFPGY+L 
Sbjct: 1013 QVRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLE 1072

Query: 2983 GNSSRRCLSNGS--WSGSSPSCLPCRCSTPVI-EYGTVNGTDF--------DCGKAARIQ 3031
            G +   CL      WS   P C+   C   V    GT+   +F        +C  + + Q
Sbjct: 1073 GTARITCLGGRRRLWSSPLPRCV-AECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQ 1131

Query: 3032 CFKGFKL----LGLSE-----------------------------ITCEADGQWSSGFPH 3058
              KG +L      LSE                             +   +   W      
Sbjct: 1132 PGKGIQLKARAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITD 1191

Query: 3059 CEHTSCG------SLPMIP---------NAFISETSSWKENVITYSCRSGYVIQGSSDLI 3103
             E+TS G      S  +I             + +   +  + +++SC  GY ++GS +L+
Sbjct: 1192 AENTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELL 1251

Query: 3104 CT--EKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCL------EGYTMD 3155
            C   E+  W +P P C     G+     +       +    E  L C+       G T+ 
Sbjct: 1252 CLSGERRTWDRPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIG 1311

Query: 3156 TDTDTFTCQK--------DGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSC 3207
                 F  ++        DG      +        LP+++     H    SV  Q S   
Sbjct: 1312 LHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKDL-----HSTFNSVVLQFSTDF 1366

Query: 3208 AEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQC 3267
                    +  SV                +  SC  P  P++G   G  +    + ++QC
Sbjct: 1367 FTSKQGFAIQFSV---------------STATSCNDPGIPQNGSRSGDSWEAGDSTVFQC 1411

Query: 3268 EPGYELEGNRERVCQ--ENR 3285
            +PGY L+G+ E  C   ENR
Sbjct: 1412 DPGYALQGSAEISCVKIENR 1431



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 50/156 (32%), Positives = 71/156 (45%), Gaps = 8/156 (5%)

Query: 398  FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYC---RVRTCPHLRQPKHGHISCSTR 454
            + ++    CHP   LVGS    C  +G WSG++  C    + TC     P+ G I  +++
Sbjct: 3088 YRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFG-IQNNSQ 3146

Query: 455  EMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNC 514
                 +T L  C +GY L+GS   TC  N  W G  P CV  HC   + P    +   + 
Sbjct: 3147 GYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDL 3206

Query: 515  GKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKW 550
               P+   T+ Y SC++GF L G  E   C   G W
Sbjct: 3207 ---PSMGYTLIY-SCQEGFSLKGGSEHRTCKADGSW 3238



 Score = 82.4 bits (202), Expect = 7e-15
 Identities = 50/156 (32%), Positives = 73/156 (46%), Gaps = 10/156 (6%)

Query: 398  FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESY--CRVRTCPHLRQPKHGHISCSTRE 455
            F A   + C PG+   G  +I C  NG WS  +S   CR+ +C  L  P +GH   +   
Sbjct: 2616 FQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLS- 2674

Query: 456  MLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCG 515
             +Y  T + +C+ GY L GS    C  N  W G E RC+  HC T     + I++ H  G
Sbjct: 2675 -VYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGT----PEPIVNGHING 2729

Query: 516  KQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
            +  +  G++ Y  C  GF L G+   + C     W+
Sbjct: 2730 ENYSYRGSVVY-QCNAGFRLIGMSVRI-CQQDHHWS 2763



 Score = 79.7 bits (195), Expect = 5e-14
 Identities = 188/856 (21%), Positives = 293/856 (34%), Gaps = 130/856 (15%)

Query: 2716 ECDLPTAPENGFLRFTETSMGSAVQYSCKPGHI-LAGSDLRLCLENRK---WSGASPRCE 2771
            EC  P  P NG        +GS++ + C  G +   GS+   C+       W+ A  RCE
Sbjct: 690  ECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAVLRCE 749

Query: 2772 AISCKKPNPVMNGSIKGSNYT--YLSTL----YYECDPGYVLNGTERRTCQDDKNWDEDE 2825
            A  C       +G+I    +   Y   L      E  PGY +  T  R  + + N+D  E
Sbjct: 750  A-PCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRF-KTEVNYDTLE 807

Query: 2826 PICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPD 2885
             +      S+P +      +  ++        T N  +LL                 T  
Sbjct: 808  -VRDGRTYSAPLIGVYHGTQVPQFLIS-----TSNYLYLLFSTDKSHSDIGFQLRYETIT 861

Query: 2886 CVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCK 2945
                 C  P    NG   G D+     VTF C  GY L     L C+ +  W   +P C+
Sbjct: 862  LQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCE 921

Query: 2946 PVNCG------PPEDLAHGFPNGFS-------FIHGGHIQYQCFPGYKLHGNSSRRCL-- 2990
             + CG          L+ GFP+ +         I   H +   F  +  H  S    L  
Sbjct: 922  AL-CGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLI 980

Query: 2991 -SNGSWSGSSPSCLPCRCSTPVIE--YGTVNG-----TDFDCGKAARIQCFKGFKLLGLS 3042
              NGS++         R   P+    YG         +DF          ++GF +   S
Sbjct: 981  TENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMS-------YEGFNIT-FS 1032

Query: 3043 EITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKE-NVITYSCRSGYVIQGSSD 3101
            E   E           CE       P +P   I +   +   + +T+SC  GY ++G++ 
Sbjct: 1033 EYDLEP----------CEE------PEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTAR 1076

Query: 3102 LICT--EKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTD 3159
            + C    + +WS P P C    CG+  +                    C+  Y++ T   
Sbjct: 1077 ITCLGGRRRLWSSPLPRCVA-ECGNSVTGTQGTLLSPNFPVNYNNNHECI--YSIQTQPG 1133

Query: 3160 TFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAE--GYTFEGVN 3217
                        + I    +   L E     +  G++ S       S +E  G T    +
Sbjct: 1134 ------------KGIQLKARAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTS 1181

Query: 3218 IS-----VCQLDGT---WEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFE-STIIYQCE 3268
             S     +   + T   +E  FS  S   + C  P +P+ G+ V  +  F  S++ + C+
Sbjct: 1182 SSLWLDFITDAENTSKGFELHFS--SFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCD 1239

Query: 3269 PGYELEGNRERVCQ--ENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCN 3326
            PGY L G+ E +C   E R W   +  C      T    + G+   +  + G    Y  N
Sbjct: 1240 PGYSLRGSEELLCLSGERRTWDRPLPTCVAECGGT----VRGEVSGQVLSPGYPAPYEHN 1295

Query: 3327 RGYSLEGPSEAHCTENGTWS-------HPVPLCKPNPCPVPFVIPE--NALLSEKEFYVD 3377
                    +EA CT    +        H V      P     ++ E     L +      
Sbjct: 1296 LNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKDLHSTF 1355

Query: 3378 QNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDM 3437
             +V ++    F     G        T T         SC  P   +N    G  ++ GD 
Sbjct: 1356 NSVVLQFSTDFFTSKQGFAIQFSVSTAT---------SCNDPGIPQNGSRSGDSWEAGDS 1406

Query: 3438 ITYSCYSGYMLEGFLRSVC--LENGTW--TSPPICRAVCRFPCQN-GGICQRPNACSCPE 3492
              + C  GY L+G     C  +EN  +   SPP C A C        G+   PN    PE
Sbjct: 1407 TVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPN---YPE 1463

Query: 3493 GW-MGRLCEEPICILP 3507
             +  G+ C+  + + P
Sbjct: 1464 PYPPGKECDWKVTVSP 1479



 Score = 73.2 bits (178), Expect = 4e-12
 Identities = 102/465 (21%), Positives = 167/465 (35%), Gaps = 83/465 (17%)

Query: 2882 ATPDCVPVR-CATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTC----QSDGN 2936
            AT + +P   C  P +L NG+ +G  +    +V + C+ G+ L G   LTC    ++   
Sbjct: 129  ATYEVLPSHTCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSAT 188

Query: 2937 WDAEIPLCKPVN-CGPPEDLAHGFPNGFSFIHGGHIQYQC---------------FPGYK 2980
            WD  +P C+  + CG       G  +   F    H    C               F  ++
Sbjct: 189  WDFPLPSCRADDACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQ 248

Query: 2981 LHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIE-------YGTVNGTDFDCGKAARIQCF 3033
            L        L      GSS          PVI        + T +G     G +A+ Q  
Sbjct: 249  LEDGYD--FLEVTGTEGSSLWFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVK 306

Query: 3034 KGFKLL--GLSEITCEADGQWSSGFPHCE----HTSCGSLPMIPNAFISETSSWK-ENVI 3086
            K  +L   G+  +  + + Q +S          H  C   P IP       S ++  + +
Sbjct: 307  KQIELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPD-PGIPERGKRLGSDFRLGSSV 365

Query: 3087 TYSCRSGYVIQGSSDLICTEKG----VWSQPYPVCEPLSCGSPPSVANAVATGEAHTYES 3142
             ++C  GY +QGS  + C +       WS   PVC    C +     + + T      + 
Sbjct: 366  QFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQY 425

Query: 3143 EVKLRCL----------------EGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPEN 3186
            +    C+                E + ++   DT T    G+   ++         +   
Sbjct: 426  DNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKT--------VLYI 477

Query: 3187 ITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEP---PFSDESCSPVSCGK 3243
            +T   V     S N Q+ +              + Q DG+        S E     SCG 
Sbjct: 478  LTGTSVPDLIVSTNHQMWL--------------LFQTDGSGSSLGFKASYEEIEQGSCGD 523

Query: 3244 PESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWS 3288
            P  P +G   GS++    T+ ++C+P +EL G +   CQ+N QWS
Sbjct: 524  PGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWS 568



 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 120/603 (19%), Positives = 205/603 (33%), Gaps = 98/603 (16%)

Query: 1789 CKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGE----WNHLIPYCKA 1844
            C  PG PE G   G  + +G+ V F+C EGY L G  +ITC++  +    W+   P C+A
Sbjct: 343  CPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRA 402

Query: 1845 VSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVK 1904
              C       +G I    F         C    T     +   LA   +       + + 
Sbjct: 403  RMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGY-DTLT 461

Query: 1905 CSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAP-PACHLVFC 1963
                    + K +L  LT  S       T + +      + + S +  +A         C
Sbjct: 462  VGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSC 521

Query: 1964 GEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDE 2023
            G+P         G+ F   +T+ + C+  + L G   I C  + +WS     C+  SC  
Sbjct: 522  GDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCV-FSC-- 578

Query: 2024 PPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKW-VPPEGQDMPRCIAHF 2082
                +  SP               S  Y     + L C     W +    +       + 
Sbjct: 579  --FFNFTSPSGV----------VLSPNYPEDYGNHLHC----VWLILARPESRIHLAFND 622

Query: 2083 CEKPPSVSYSILESVSKAK------FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSP 2136
             +  P   + +++  + A+      F+   + S     G V    A++E           
Sbjct: 623  IDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHV----ARLEFQTDHSTGKRG 678

Query: 2137 MSIQCIPVR---CGEPPSIMNGYASGSNYSFGAMVAYSCNKGFY-IKGEKKSTC---EAT 2189
             +I     R   C +P   +NG   G +   G+ +++ C++GF   +G +  TC   E +
Sbjct: 679  FNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGS 738

Query: 2190 GQWSSPIPTCH-------------------------PVSCGEPPKVENGFLEHTTGRIFE 2224
              W+S +  C                           +SC    + + G+    T   F+
Sbjct: 739  VVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFK 798

Query: 2225 SEVRY---QCNPG----------YKSVGSPVFVCQANRHW---------HSE-------S 2255
            +EV Y   +   G          Y     P F+   + +          HS+        
Sbjct: 799  TEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYE 858

Query: 2256 PLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSN 2315
             +      C  P    NG   G +F VG+ V F C+ GY L       C+ + +W+ ++ 
Sbjct: 859  TITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWS-RAL 917

Query: 2316 PKC 2318
            P C
Sbjct: 918  PSC 920



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 121/504 (24%), Positives = 183/504 (36%), Gaps = 113/504 (22%)

Query: 2527 GFRLEGP--SALTCLET---GDWDVDAPSCNAIH-------CDSPQPIENGFVEGADYSY 2574
            GF+L     SA T L      D+ V A   +A +       C +P  + NG  +G+ ++ 
Sbjct: 98   GFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCGNPGRLPNGIQQGSTFNL 157

Query: 2575 GAIIIYSCFPGFQVAGHAMQTC-----EESGWSSSIPTCMPID-CG----------LPPH 2618
            G  + YSC  GF + GHA+ TC       + W   +P+C   D CG            PH
Sbjct: 158  GDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRGQSGIISSPH 217

Query: 2619 I-----DFGDCT-----KLKDDQGY----FEQED--DMMEVPYVTPHPPYHLGAVAKTWE 2662
                  +  DCT     +L D        F+ ED  D +EV        +  GA      
Sbjct: 218  FPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFLEVTGTEGSSLWFTGA------ 271

Query: 2663 NTKESPATHSSNFL------------YGTMVSYTCNPGYELLGNPV-LICQEDGTWNGSA 2709
             +  +P   S N+L             G    Y      EL    V L+  +D +   S 
Sbjct: 272  -SLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKSRGVKLMPSKDNSQKTSV 330

Query: 2710 PSCISIE-----CDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLE----N 2760
             + + +      C  P  PE G    ++  +GS+VQ++C  G+ L GS    C++     
Sbjct: 331  LTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMF 390

Query: 2761 RKWSGASPRCEAISC----KKPNPVM---NGSIKGSNYTYLSTLYYECDPGYVL------ 2807
              WS   P C A  C    + P+ ++   N  I+  N  +   +    +P  V+      
Sbjct: 391  AAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEE 450

Query: 2808 ----NGTERRTCQDDKNWDEDEPICIPVDCSSPP---VSANGQVRGDEYTFQKEIEYTCN 2860
                 G +  T  D     + + +   +  +S P   VS N Q+      FQ     T  
Sbjct: 451  FDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQM---WLLFQ-----TDG 502

Query: 2861 EGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEG 2920
             G  L    S   +  GS            C  P   A G  EG  +     + F C   
Sbjct: 503  SGSSLGFKASYEEIEQGS------------CGDPGIPAYGRREGSRFHHGDTLKFECQPA 550

Query: 2921 YILHGAPKLTCQSDGNWDAEIPLC 2944
            + L G   +TCQ +  W A+ P C
Sbjct: 551  FELVGQKAITCQKNNQWSAKKPGC 574



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 126/612 (20%), Positives = 202/612 (33%), Gaps = 163/612 (26%)

Query: 1788 KCKAPGNPENGHSSGEIYTVGAEVTFSCQEGY-QLMGVTKITC-LESGE--WNHLIPYCK 1843
            +C  PG P NG   G+   +G+ ++F C EG+    G   ITC L+ G   WN  +  C+
Sbjct: 690  ECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAVLRCE 749

Query: 1844 AVSCGKPAIPENGCIEELAFTFGSKVTYRC------NKGYTL--------AGDKESSCLA 1889
            A  CG      +G I    +    K    C        GY +              +   
Sbjct: 750  A-PCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEV 808

Query: 1890 NSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYL----STASYSCDTGYSLQGPSIIEC 1945
                ++S P+               ++++S   YL    ST     D G+ L+  +I   
Sbjct: 809  RDGRTYSAPL-----IGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETI--- 860

Query: 1946 TASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLA 2005
                             C +P    +    GN+F     VT++C  GYTL+  + +EC  
Sbjct: 861  -----------TLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEP 909

Query: 2006 DGKWSRSDQQCLA-----VSCDEPPIVDHASP-------------ETAHRLFGDIAFYYC 2047
            + +WSR+   C A     +      I+    P             ET+H   G   F+  
Sbjct: 910  NFQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSH---GKGVFFTF 966

Query: 2048 SDGYSLADNSQLLCNAQGKWVPP----EGQDMP---------------RCIAHF------ 2082
               +  + +  LL    G +  P     G  +P               R I+ F      
Sbjct: 967  HTFHLESGHDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEG 1026

Query: 2083 ------------CEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGG 2130
                        CE+P   +YSI + +   +F  G  ++F C  G+ L  +A+I C+ G 
Sbjct: 1027 FNITFSEYDLEPCEEPEVPAYSIRKGL---QFGVGDTLTFSCFPGYRLEGTARITCLGGR 1083

Query: 2131 Q--WNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSC--------NKGFYIKG 2180
            +  W+ SP+  +C+   CG   +   G     N+       + C         KG  +K 
Sbjct: 1084 RRLWS-SPLP-RCV-AECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKA 1140

Query: 2181 EKKSTCE---------------------------------ATGQWSSPIPTCHPVS---- 2203
                  E                                 ++  W   I      S    
Sbjct: 1141 RAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFE 1200

Query: 2204 ----------CGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHS 2253
                      C +P   + G+  H  G    S V + C+PGY   GS   +C +      
Sbjct: 1201 LHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTW 1260

Query: 2254 ESPLMCVPLDCG 2265
            + PL     +CG
Sbjct: 1261 DRPLPTCVAECG 1272



 Score = 69.7 bits (169), Expect = 5e-11
 Identities = 170/820 (20%), Positives = 274/820 (33%), Gaps = 197/820 (24%)

Query: 1684 HCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSC 1743
            HC  +  G+P    NG    +DFY G+ VT+ C++GY L     + C  N  W+   PSC
Sbjct: 866  HC--LDPGIPV---NGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSC 920

Query: 1744 LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGE 1803
                E   G             G+ +    P +  +  NC   I        E  H  G 
Sbjct: 921  ----EALCGGFIQ------GSSGTILSPGFPDFYPNNLNCTWII--------ETSHGKGV 962

Query: 1804 IYTVGAEVTFSCQEGY----------------QLMGVTKITCLESGEWNHLIPYCKAVS- 1846
             +T     TF  + G+                QL G      + +G + +     + +S 
Sbjct: 963  FFTFH---TFHLESGHDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISD 1019

Query: 1847 -------------------CGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSC 1887
                               C +P +P     + L F  G  +T+ C  GY L G    +C
Sbjct: 1020 FSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITC 1079

Query: 1888 LANSS--WSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIEC 1945
            L      WS   P C   +C +      G  +          ++ C   YS+Q       
Sbjct: 1080 LGGRRRLWSSPLPRC-VAECGNSVTGTQGTLLSPNFPVNYNNNHECI--YSIQTQ----- 1131

Query: 1946 TASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKE--GYTLAGLDT--- 2000
               GI  +A          E   +K  V  GNN + R    ++  E  G TL    +   
Sbjct: 1132 PGKGIQLKA----RAFELSEGDVLK--VYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLW 1185

Query: 2001 IECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLF------GDIAFYYCSDGYSLA 2054
            ++ + D + +    +    S +     D  +P+  +++       G    + C  GYSL 
Sbjct: 1186 LDFITDAENTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLR 1245

Query: 2055 DNSQLLC--NAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKC 2112
             + +LLC    +  W  P    +P C+A           ++   VS    + G    ++ 
Sbjct: 1246 GSEELLCLSGERRTWDRP----LPTCVA-------ECGGTVRGEVSGQVLSPGYPAPYEH 1294

Query: 2113 MEGFVLNTSAKIECMRG-------GQWNPSPMSIQCIPVRCGEPPSIMNGYA--SGSNYS 2163
                +    A+  C  G        +     + I   PV  G     ++G A     + +
Sbjct: 1295 NLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKDLHST 1354

Query: 2164 FGAMVA------YSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEH 2217
            F ++V       ++  +GF I            Q+S    T    SC +P   +NG    
Sbjct: 1355 FNSVVLQFSTDFFTSKQGFAI------------QFSVSTAT----SCNDPGIPQNGSRSG 1398

Query: 2218 TTGRIFESEVRYQCNPGYKSVGSPVFVCQ--ANRHWHSESPLMCVPLDCGKPPPIQNGFM 2275
             +    +S V +QC+PGY   GS    C    NR +   SP  C+   CG      +G +
Sbjct: 1399 DSWEAGDSTV-FQCDPGYALQGSAEISCVKIENRFFWQPSPPTCI-APCGGDLTGPSGVI 1456

Query: 2276 KGENF--------EVGSKVQ-------------FFCNEGYE-------------LVGDSS 2301
               N+        E   KV              F    GY+             L+G S 
Sbjct: 1457 LSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPLIG-SF 1515

Query: 2302 WTCQKSGKWNKKSNPKCMPAK---------------------CPEPPLLENQLVLKELTT 2340
            +  Q  G+    SN   +  +                     C +P  ++N   +     
Sbjct: 1516 YGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLK 1575

Query: 2341 EVGVVTFSCKEGHVLQGPSVLKCLPSQQ----WNDSFPVC 2376
                VT+ C  G+ ++G S L C+        WN+  PVC
Sbjct: 1576 LGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVC 1615



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 67/270 (24%), Positives = 103/270 (38%), Gaps = 34/270 (12%)

Query: 306  ICEKGYYGKGLQY-ECTACPSGTYKPEGSPGGISSC--IPCPDENHT----SPPGSTS-- 356
            IC+ GYY  G +   C A    +         I SC  +P P   H     S  G+T+  
Sbjct: 2623 ICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIF 2682

Query: 357  ------------PEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGV 404
                          +C+    +  S   C   HC   +P  NG+   N  N  +  +   
Sbjct: 2683 SCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHI--NGENYSYRGSVVY 2740

Query: 405  RCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLV 464
            +C+ GF L+G S+ +C  +  WSG   +C + +C H   P H  +S  +    Y    +V
Sbjct: 2741 QCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGDS----YTVGAVV 2796

Query: 465  --ACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPA-KF 521
              +C     L G+    C  +  W G  P C     ++  +  D  I  H      +   
Sbjct: 2797 RYSCIGKRTLVGNSTRMCGLDGHWTGSLPHC---SGTSVGVCGDPGIPAHGIRLGDSFDP 2853

Query: 522  GTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
            GT+   SC  G +L G  E   C  +G W+
Sbjct: 2854 GTVMRFSCEAGHVLRGSSER-TCQANGSWS 2882



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 67/298 (22%), Positives = 109/298 (36%), Gaps = 58/298 (19%)

Query: 307  CEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCV----- 361
            CE G+  +G   E T   +G++       G+ SC           PG+ S    V     
Sbjct: 2861 CEAGHVLRGSS-ERTCQANGSWSGSQPECGVISC---------GNPGTPSNARVVFSDGL 2910

Query: 362  ---------CREGYRASG----------------QTCELVHCPALKPPENGYFIQNTCNN 396
                     CREGY A+G                  C +++C     P NG  + N  + 
Sbjct: 2911 VFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGN--DF 2968

Query: 397  HFNAACGVRCHPGFDLVGS--SIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTR 454
             +N     +C PG+ +     S++ C  +  W+G++  C+   C       +G +  S  
Sbjct: 2969 RYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGS-- 3026

Query: 455  EMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNC 514
            + ++ ++   AC EGY+L      TC+GN  W G  P+C    C    +P     S    
Sbjct: 3027 DFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVP-----SRGRR 3081

Query: 515  GKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN------VGVQAAVCKDVEAPQ 566
              +   + +    SC    +L G      C + G W+      +      C D   PQ
Sbjct: 3082 EDRGFSYRSSVSFSCHPPLVLVGSPRRF-CQSDGTWSGTQPSCIDPTLTTCADPGVPQ 3138



 Score = 64.7 bits (156), Expect = 2e-09
 Identities = 55/214 (25%), Positives = 84/214 (39%), Gaps = 21/214 (9%)

Query: 361  VCREGYRASGQT--CELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSII 418
            +C++ +  SG+T  C LV C     P +     ++      A     C     LVG+S  
Sbjct: 2755 ICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGDSYT--VGAVVRYSCIGKRTLVGNSTR 2812

Query: 419  LCLPNGLWSGSESYCR---VRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGS 475
            +C  +G W+GS  +C    V  C     P HG     + +    T    +C+ G+ L GS
Sbjct: 2813 MCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDP--GTVMRFSCEAGHVLRGS 2870

Query: 476  DKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFIL 535
             + TCQ N  W G +P C    C     P +  +           F +     CR+G+  
Sbjct: 2871 SERTCQANGSWSGSQPECGVISCGNPGTPSNARV----VFSDGLVFSSSIVYECREGYYA 2926

Query: 536  SGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINC 569
            +G+     C+ +G W          D E   INC
Sbjct: 2927 TGLLSR-HCSVNGTW-------TGSDPECLVINC 2952



 Score = 63.2 bits (152), Expect = 5e-09
 Identities = 60/260 (23%), Positives = 105/260 (40%), Gaps = 35/260 (13%)

Query: 334  PGGISSCIPCPDENHTSPPGSTSPEDCVC----------REGYRASGQTCELVHCPALKP 383
            P G S  +     N+++P   TS  + V           R+G++         +C   + 
Sbjct: 2417 PSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSA---PYCSLPRA 2473

Query: 384  PENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCL--PNG--LWSGSESYCRVRTCP 439
            P +G+ +  T       +    C+ G+ LVG S+ +C   P G  LWS +   C+  +C 
Sbjct: 2474 PLHGFILGQTSTQP-GGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCG 2532

Query: 440  HLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLT--CQGNSQWDGPE--PRCVE 495
                PK+G +    +E    T  + +C EGY L+   + T  C     W      P+CV 
Sbjct: 2533 LPEAPKNGMVF--GKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVP 2590

Query: 496  RHCSTFQMPKDVIISPHN-----CGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKW 550
              C     P    IS  +       +   +F     + C  G+  +G + ++RC  +GKW
Sbjct: 2591 VTC-----PDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTG-QRVIRCQANGKW 2644

Query: 551  NVGVQAAVCKDVEAPQINCP 570
            ++G     C+ +   ++  P
Sbjct: 2645 SLGDSTPTCRIISCGELPIP 2664



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 33/93 (35%), Positives = 46/93 (49%), Gaps = 4/93 (4%)

Query: 405  RCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISC-STREMLYKTTCL 463
            RC  G+ L GS+   CLPN  WSG+   C    C     P H ++       M Y  T +
Sbjct: 3157 RCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGY--TLI 3214

Query: 464  VACDEGYRLEG-SDKLTCQGNSQWDGPEPRCVE 495
             +C EG+ L+G S+  TC+ +  W G  P C+E
Sbjct: 3215 YSCQEGFSLKGGSEHRTCKADGSWTGKPPICLE 3247



 Score = 56.2 bits (134), Expect = 6e-07
 Identities = 103/484 (21%), Positives = 154/484 (31%), Gaps = 92/484 (19%)

Query: 1689 SCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFC----TDNGSWNGVSPSCL 1744
            +CG P  L NG      F  G  V Y CN G++L G + + C     ++ +W+   PSC 
Sbjct: 138  TCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCR 197

Query: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEI 1804
              D C            L      I S  P +  +  N A+   C      E G +   +
Sbjct: 198  ADDAC---------GGTLRGQSGIISS--PHFPSEYHNNAD---CTWTILAELGDTIALV 243

Query: 1805 YTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFT 1864
            +     + F  ++GY  + VT        E + L  +    S   P I     +  L FT
Sbjct: 244  F-----IDFQLEDGYDFLEVT------GTEGSSL--WFTGASLPAPVISSKNWL-RLHFT 289

Query: 1865 F-------GSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPV-------KCSSPEN 1910
                    G    Y+  K   L   +    + +   S    V   V        C  P  
Sbjct: 290  SDGNHRQRGFSAQYQVKKQIELK-SRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGI 348

Query: 1911 INNGKYILSGLTYLSTASYSCDTGYSLQGPSIIEC----TASGIWDRAPPACHLVFCGEP 1966
               GK + S     S+  ++C+ GY LQG   I C         W    P C    C   
Sbjct: 349  PERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAH 408

Query: 1967 PAIKDAVITGNNFTFR-----------------NTVTYTCKEGYTLAGLDTIECLADGKW 2009
                  +IT  NF  +                   +    +E     G DT+  + DG  
Sbjct: 409  LRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTL-TVGDGGQ 467

Query: 2010 SRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVP 2069
                +  L +       V      T H+++  + F     G SL   +      QG    
Sbjct: 468  DGDQKTVLYILTGTS--VPDLIVSTNHQMW--LLFQTDGSGSSLGFKASYEEIEQGS--- 520

Query: 2070 PEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRG 2129
                         C  P   +Y   E    ++F  G  + F+C   F L     I C + 
Sbjct: 521  -------------CGDPGIPAYGRREG---SRFHHGDTLKFECQPAFELVGQKAITCQKN 564

Query: 2130 GQWN 2133
             QW+
Sbjct: 565  NQWS 568



 Score = 53.5 bits (127), Expect = 4e-06
 Identities = 61/280 (21%), Positives = 105/280 (37%), Gaps = 63/280 (22%)

Query: 3241 CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQ----WSGGVAICKE 3296
            C  P  PE G  +GS +   S++ + C  GY+L+G++   C +       WS    +C+ 
Sbjct: 343  CPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRA 402

Query: 3297 TRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNP 3356
              C+     L G + I    T PN        + ++  + AHC    T  +P  + K   
Sbjct: 403  RMCDA---HLRGPSGI---ITSPN--------FPIQYDNNAHCVWIITALNPSKVIK--- 445

Query: 3357 CPVPFVIPENALLSEKEFYVDQNV-SIKCREG----------FLLQGHGI---ITCNPDE 3402
                        L+ +EF +++   ++   +G          ++L G  +   I     +
Sbjct: 446  ------------LAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQ 493

Query: 3403 TWT--QTSA------------KCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYML 3448
             W   QT              + E+ SCG P         G  + +GD + + C   + L
Sbjct: 494  MWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFEL 553

Query: 3449 EGFLRSVCLENGTWTS-PPICRAVCRFPCQN-GGICQRPN 3486
             G     C +N  W++  P C   C F   +  G+   PN
Sbjct: 554  VGQKAITCQKNNQWSAKKPGCVFSCFFNFTSPSGVVLSPN 593



 Score = 44.7 bits (104), Expect = 0.002
 Identities = 23/61 (37%), Positives = 30/61 (49%), Gaps = 5/61 (8%)

Query: 3415 SCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVC----LENGTWTSP-PICR 3469
            +CG P  + N I +G  +  GD + YSC  G+ LEG     C      + TW  P P CR
Sbjct: 138  TCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCR 197

Query: 3470 A 3470
            A
Sbjct: 198  A 198



 Score = 42.7 bits (99), Expect = 0.006
 Identities = 81/444 (18%), Positives = 148/444 (33%), Gaps = 87/444 (19%)

Query: 1686 ERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLD 1745
            E+ SCG P     G      F+ G T+ ++C   + L+G   + C  N  W+   P C  
Sbjct: 517  EQGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGC-- 574

Query: 1746 VDECAVG--------------SDCSEHASCL---------NVDGSYICSCVPP-----YT 1777
            V  C                  D   H  C+          +  ++    V P       
Sbjct: 575  VFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVI 634

Query: 1778 GDGKNCAEPIKCKAPGN--PENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEW 1835
             DG     P+     GN  P +  SSG +  +  +   S   G +   +T  T   +   
Sbjct: 635  KDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHS--TGKRGFNITFTTFRHN--- 689

Query: 1836 NHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYT-LAGDKESSCLANSS-- 1892
                       C  P +P NG     +   GS +++ C++G+    G +  +C+      
Sbjct: 690  ----------ECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSV 739

Query: 1893 -WSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSC------DTGYSL-----QGP 1940
             W+ +   CE   C       +G  +  G       + SC        GY +     +  
Sbjct: 740  VWNSAVLRCE-APCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFK 798

Query: 1941 SIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGL-- 1998
            + +      + D    +  L+       +   +I+ +N+ +   + ++  + ++  G   
Sbjct: 799  TEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLY---LLFSTDKSHSDIGFQL 855

Query: 1999 --DTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADN 2056
              +TI   +D              C +P I  +          G +  + C  GY+L+D 
Sbjct: 856  RYETITLQSD-------------HCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDG 902

Query: 2057 SQLLCNAQGKWVPPEGQDMPRCIA 2080
              L C    +W     + +P C A
Sbjct: 903  EPLECEPNFQW----SRALPSCEA 922



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 17/47 (36%), Positives = 24/47 (51%)

Query: 466 CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPH 512
           C   + L G   +TCQ N+QW   +P CV      F  P  V++SP+
Sbjct: 547 CQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFNFTSPSGVVLSPN 593



 Score = 41.6 bits (96), Expect = 0.014
 Identities = 23/74 (31%), Positives = 35/74 (47%), Gaps = 5/74 (6%)

Query: 2366 SQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLC--- 2422
            +Q ++ ++ V     C  P  +  G+    S  + G  V+YSC  GFFL G++   C   
Sbjct: 124  AQGFHATYEVLPSHTCGNPGRLPNGIQ-QGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAG 182

Query: 2423 -QPDGTWSSPLPEC 2435
             +   TW  PLP C
Sbjct: 183  SENSATWDFPLPSC 196



 Score = 40.8 bits (94), Expect = 0.024
 Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 2/54 (3%)

Query: 461  TCLVACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCVERHCSTFQMPKDVIISPH 512
            T   +C  GYRLEG+ ++TC G  +  W  P PRCV    ++    +  ++SP+
Sbjct: 1060 TLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPN 1113



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 55/251 (21%), Positives = 90/251 (35%), Gaps = 39/251 (15%)

Query: 3181 CPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQL----DGTWEPPF----S 3232
            C  P  + + +  G  F++  +V  SC  G+  EG  +  C        TW+ P     +
Sbjct: 139  CGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRA 198

Query: 3233 DESCSPVSCGKP---ESPEHGFVVGSKYTFESTII-------------YQCEPGY---EL 3273
            D++C     G+     SP       +      TI+             +Q E GY   E+
Sbjct: 199  DDACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFLEV 258

Query: 3274 EGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEG 3333
             G      + +  W  G ++            L+  +D  +R  G +  Y   +   L+ 
Sbjct: 259  TGT-----EGSSLWFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKS 313

Query: 3334 ------PSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREG 3387
                  PS+ +  +    +        N CP P  IPE       +F +  +V   C EG
Sbjct: 314  RGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPG-IPERGKRLGSDFRLGSSVQFTCNEG 372

Query: 3388 FLLQGHGIITC 3398
            + LQG   ITC
Sbjct: 373  YDLQGSKRITC 383



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 20/63 (31%), Positives = 29/63 (46%), Gaps = 5/63 (7%)

Query: 3415 SCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCL----ENGTWTSP-PICR 3469
            SC  P  ++N    G   + G  +TY C+ GY +EG     C+        W +P P+C 
Sbjct: 1557 SCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCT 1616

Query: 3470 AVC 3472
            A C
Sbjct: 1617 APC 1619



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 24/99 (24%), Positives = 44/99 (44%), Gaps = 4/99 (4%)

Query: 437  TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNS--QWDGPEPRCV 494
            +CP    P +G +    R ++        C+ GY L+G   ++C   +  +W+ P P C+
Sbjct: 1908 SCPEPAVPSNG-VKTGERYLVNDVVSF-QCEPGYALQGHAHISCMPGTVRRWNYPPPLCI 1965

Query: 495  ERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGF 533
             +   T +  + VI+SP   G  P+       ++   GF
Sbjct: 1966 AQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGF 2004



 Score = 36.2 bits (82), Expect = 0.60
 Identities = 19/52 (36%), Positives = 26/52 (50%), Gaps = 5/52 (9%)

Query: 466 CDEGYRLEGSDKLTCQGNSQ----WDGPEPRCVERHCST-FQMPKDVIISPH 512
           C+EGY L+GS ++TC   S     W    P C  R C    + P  +I SP+
Sbjct: 369 CNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPN 420



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 19/48 (39%), Positives = 23/48 (47%), Gaps = 2/48 (4%)

Query: 465 ACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTF-QMPKDVIISP 511
           +CD GY L   + L C+ N QW    P C E  C  F Q     I+SP
Sbjct: 892 SCDSGYTLSDGEPLECEPNFQWSRALPSC-EALCGGFIQGSSGTILSP 938



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 15/32 (46%), Positives = 19/32 (59%), Gaps = 2/32 (6%)

Query: 465  ACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCV 494
            +CD GY L GS++L C    +  WD P P CV
Sbjct: 1237 SCDPGYSLRGSEELLCLSGERRTWDRPLPTCV 1268



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 25/74 (33%), Positives = 30/74 (40%), Gaps = 11/74 (14%)

Query: 378 CPALKPPENGYFIQNTCNNHFNAACGVR--CHPGFDLVGSSIILCLP----NGLWSGSES 431
           CP    PE G        + F     V+  C+ G+DL GS  I C+        WS    
Sbjct: 343 CPDPGIPERG----KRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRP 398

Query: 432 YCRVRTC-PHLRQP 444
            CR R C  HLR P
Sbjct: 399 VCRARMCDAHLRGP 412



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 21/81 (25%), Positives = 32/81 (39%), Gaps = 6/81 (7%)

Query: 3357 CPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNP----DETWTQTSAKCE 3412
            C  P  +P N +     F +   V   C  GF L+GH ++TC+       TW      C 
Sbjct: 139  CGNPGRLP-NGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCR 197

Query: 3413 -KISCGPPAHVENAIARGVHY 3432
               +CG     ++ I    H+
Sbjct: 198  ADDACGGTLRGQSGIISSPHF 218



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 20/69 (28%), Positives = 26/69 (37%), Gaps = 2/69 (2%)

Query: 365 GYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNG 424
           G++AS +  E   C    P    Y  +     H        C P F+LVG   I C  N 
Sbjct: 508 GFKASYEEIEQGSCG--DPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNN 565

Query: 425 LWSGSESYC 433
            WS  +  C
Sbjct: 566 QWSAKKPGC 574



 Score = 33.5 bits (75), Expect = 3.9
 Identities = 16/50 (32%), Positives = 24/50 (48%), Gaps = 3/50 (6%)

Query: 466  CDEGYRLEGSDKLTC---QGNSQWDGPEPRCVERHCSTFQMPKDVIISPH 512
            CD GY L+GS +++C   +    W    P C+         P  VI+SP+
Sbjct: 1411 CDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPN 1460



 Score = 33.1 bits (74), Expect = 5.1
 Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 6/54 (11%)

Query: 465 ACDEGYRLEGSDKLTCQGNSQ----WDGPEPRC-VERHC-STFQMPKDVIISPH 512
           +C+ G+ LEG   LTC   S+    WD P P C  +  C  T +    +I SPH
Sbjct: 164 SCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRGQSGIISSPH 217



 Score = 33.1 bits (74), Expect = 5.1
 Identities = 21/78 (26%), Positives = 35/78 (44%), Gaps = 8/78 (10%)

Query: 466  CDEGYRLEGSDKLTC----QGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKF 521
            C  GY +EG+  L+C     G   W+ P P C       +     V++SP+    Q    
Sbjct: 1584 CHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNY--PQNYTS 1641

Query: 522  GTIC--YVSCRQGFILSG 537
            G IC  +V+  + +++ G
Sbjct: 1642 GQICLYFVTVPKDYVVFG 1659



 Score = 32.7 bits (73), Expect = 6.6
 Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 3/59 (5%)

Query: 364  EGYRASGQTCELVHCPALKPPENGYFIQNTCNNHF-NAACGVRCHPGFDLVGSSIILCL 421
            +G+     + EL+ C     P+ GY + +    HF  ++    C PG+ L GS  +LCL
Sbjct: 1197 KGFELHFSSFELIKCEDPGTPKFGYKVHD--EGHFAGSSVSFSCDPGYSLRGSEELLCL 1253



 Score = 32.7 bits (73), Expect = 6.6
 Identities = 15/30 (50%), Positives = 17/30 (56%), Gaps = 2/30 (6%)

Query: 466  CDEGYRLEGSDKLTCQ--GNSQWDGPEPRC 493
            C  GY+L G   LTCQ   N  WD P P+C
Sbjct: 2149 CLPGYQLTGHPVLTCQHGTNRNWDHPLPKC 2178


>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
            isoform 1 [Homo sapiens]
          Length = 1092

 Score =  401 bits (1030), Expect = e-111
 Identities = 308/1079 (28%), Positives = 464/1079 (43%), Gaps = 162/1079 (15%)

Query: 1632 PRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQ----GQWTQPLPHCER 1687
            P L G + +  T    +  G+ +   C   F+L+G     C+ +    G W +P P CE 
Sbjct: 28   PILNGRISYYSTP---IAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEY 84

Query: 1688 IS--CGVPPPLENG---FHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVS-P 1741
             +     P P+  G      +  +  G +VT+ C   + + G+  ++C  N  W     P
Sbjct: 85   FNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLP 144

Query: 1742 SCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSS 1801
            +C+ V                                       P++C A     NGH +
Sbjct: 145  TCVSV--------------------------------------FPLECPALPMIHNGHHT 166

Query: 1802 GE---IYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCI 1858
             E       G  VT+SC+ GY L+G   I CL SG+W+ + P C+   C       NG +
Sbjct: 167  SENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKV 226

Query: 1859 EE-LAFTFGSKVTYRCNKGYTLAGDKESSCL---ANSSWSHSPPVCEPVKCSSPENINNG 1914
            +E      G    + C++GY L G   S C+      +W+   PVCE + C SP  I NG
Sbjct: 227  KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNG 285

Query: 1915 KYI---LSGLTYLSTASYSCD------TGYSLQGPSIIECTA----SGIWDRAPPACHL- 1960
            ++I   L+ ++Y S  +Y+CD        + L G S + CT     +G W    P C L 
Sbjct: 286  RHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELS 345

Query: 1961 ---VFCGEPPAIKDAVITG--NNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQ 2015
               V C  P  ++  +++G  + +T+ +TV + C  G+TL G   I C A G W  S   
Sbjct: 346  TSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPV 405

Query: 2016 CLAVSCDEPPIVDHASPETAHRLF---GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEG 2072
            C    C  PP + +   E  H +    G    Y C+ GY L     + C ++G W PP  
Sbjct: 406  C-EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPP-- 462

Query: 2073 QDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQW 2132
              +P+C    CE     +   L +  + +F    V S  C EG+ L+ S   EC     W
Sbjct: 463  --VPQCKVAACE----ATGRQLLTKPQHQFVRPDVNS-SCGEGYKLSGSVYQECQGTIPW 515

Query: 2133 NPSPMSIQ-CIPVRCGEPPSIMNGYASGS---NYSFGAMVAYSCNKG------FYIKGEK 2182
                M I+ C  + C  PP I NG  +GS   ++ +G  V Y+CN G      F + GE 
Sbjct: 516  F---MEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGES 572

Query: 2183 KSTC----EATGQWSSPIPTCH----PVSCGEPPKVENGFLEHTTGR----IFESEVRYQ 2230
               C    +  G WS P P C      V C     + NG+    +G+     +   V ++
Sbjct: 573  TIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH-VHIANGY--KISGKEAPYFYNDTVTFK 629

Query: 2231 CNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGEN---FEVGSKVQ 2287
            C  G+   GS    C+A+  W  E P+      C  PP + +G   G N   F  G  V 
Sbjct: 630  CYSGFTLKGSSQIRCKADNTWDPEIPV--CEKGCQSPPGLHHGRHTGGNTVFFVSGMTVD 687

Query: 2288 FFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELT--TEVGVV 2345
            + C+ GY LVG+ S  C  SG W+  S P+C      E      +  L+EL   + V +V
Sbjct: 688  YTCDPGYLLVGNKSIHCMPSGNWS-PSAPRC------EETCQHVRQSLQELPAGSRVELV 740

Query: 2346 TFSCKEGHVLQGPSVLKCLPSQQ--WNDSFPVCKIVLCTPPPLISFGVPIPSSALHF--G 2401
              SC++G+ L G +   C  ++   W    P+CK++ C PPP+I  G      A +F  G
Sbjct: 741  NTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYG 800

Query: 2402 STVKYSCVGGFFLRGNSTTLCQPD----GTWSSPLPECV---PV-ECPQPEEIPNGIIDV 2453
            + V Y C  GF+L G     C+ D    G+WS P P+C+   PV  CP PE      ++ 
Sbjct: 801  NEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNK 860

Query: 2454 QGLAYLSTAL--YTCKPGFELVGNTTTLCGENGHWLGGKPTC--KA-IECLKPKEILNGK 2508
               AY    +    C PGF + G+    C  +  W+ G PTC  KA I C  P +  NG 
Sbjct: 861  THSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGN 920

Query: 2509 FSYTDL---HYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSP---QPI 2562
             +  ++     G ++ YSC++G+ L G + L C   G W   AP C  ++C SP     I
Sbjct: 921  HTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGI 980

Query: 2563 ENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCE-ESGWSSSIPTC-----MPIDCGL 2615
            + G      Y YGA++   C  G+ + G     C+ +  W+  +  C      P+ CG+
Sbjct: 981  QKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCGI 1039



 Score =  381 bits (979), Expect = e-105
 Identities = 298/1024 (29%), Positives = 439/1024 (42%), Gaps = 126/1024 (12%)

Query: 2262 LDCGKPPPIQNGFMK--GENFEVGSKVQFFCNEGYELVGDSSWTC----QKSGKWNKKSN 2315
            + CG PPPI NG +        VG+ +++ C+  + L+G+ S  C    +  G W+K + 
Sbjct: 21   ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPA- 79

Query: 2316 PKC----MPAKCPEPPLLENQLVLKELTTEVG-VVTFSCKEGHVLQGPSVLKCLPSQQWN 2370
            PKC      + CPEP +     +        G  VTF+CK    + G   + C  +  W 
Sbjct: 80   PKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWG 139

Query: 2371 DS-FPVCKIVL---CTPPPLISFGVPIPSS--ALHFGSTVKYSCVGGFFLRGNSTTLCQP 2424
             +  P C  V    C   P+I  G     +  ++  G +V YSC  G+ L G     C  
Sbjct: 140  PTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLS 199

Query: 2425 DGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLS-TALYTCKPGFELVGNTTTLC--- 2480
             G WS+  P C    C      PNG +    +  +  TA + C  G+ L G  ++ C   
Sbjct: 200  SGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIA 259

Query: 2481 GENGHWLGGKPTCKAIECLKPKEILNGKF---SYTDLHYGQTVTYSCNR------GFRLE 2531
            G+   W    P C+ I C  P  ILNG+    S  ++ YG  VTY+C+        F L 
Sbjct: 260  GQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILI 318

Query: 2532 GPSALTCL----ETGDWDVDAPSC----NAIHCDSPQPIENGFVEGAD--YSYGAIIIYS 2581
            G S L C     +TG W   AP C    +A+ C  PQ +    V G    Y+Y   +I++
Sbjct: 319  GESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFA 378

Query: 2582 CFPGFQVAGHAMQTCEESG-WSSSIPTCMPIDCGLPPHI-------------DFGDCTKL 2627
            C  GF + G     C   G W  S P C   +C  PP+I             D G   K 
Sbjct: 379  CMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKEDRHMVRFDPGTSIKY 437

Query: 2628 KDDQGYFEQEDDMMEVP----YVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSY 2683
              + GY    ++ ++      +  P P   + A     E T     T   +      V+ 
Sbjct: 438  SCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAAC----EATGRQLLTKPQHQFVRPDVNS 493

Query: 2684 TCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSM-----GSA 2738
            +C  GY+L G+    CQ    W      C  I C  P    NG    T +S+     G+ 
Sbjct: 494  SCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNG--AHTGSSLEDFPYGTT 551

Query: 2739 VQYSCKPG------HILAGSDLRLCLENRK----WSGASPRCE----AISCKKPNPVMNG 2784
            V Y+C PG        L G     C  N +    WSG +P C+    A+ C   + + NG
Sbjct: 552  VTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVH-IANG 610

Query: 2785 ---SIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSAN 2841
               S K + Y Y  T+ ++C  G+ L G+ +  C+ D  WD + P+C    C SPP   +
Sbjct: 611  YKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVC-EKGCQSPPGLHH 669

Query: 2842 GQVRGDEYTF---QKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLA 2898
            G+  G    F      ++YTC+ G+LL G +S  C+ +G+WS + P     RC    Q  
Sbjct: 670  GRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAP-----RCEETCQHV 724

Query: 2899 NGVTEGLDYGFMKE-VTFHCHEGYILHGAPKLTCQS--DGNWDAEIPLCKPVNCGPPEDL 2955
                + L  G   E V   C +GY L G     CQ   +G W  +IPLCK ++C PP  +
Sbjct: 725  RQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVI 784

Query: 2956 AHGFPNGF---SFIHGGHIQYQCFPGYKLHGNSSRRCLSN----GSWSGSSPSCLPC--- 3005
             +G   G    +F++G  + Y+C  G+ L G    +C S+    GSWSG SP CL     
Sbjct: 785  VNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPV 844

Query: 3006 -RCSTPVIEYG-TVNGTD--FDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHC-- 3059
             RC  P +++G  +N T   +       + C  GF + G   I C  D  W  G P C  
Sbjct: 845  TRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIK 904

Query: 3060 -EHTSCGSLPMIPNAFISETSSWKENV---ITYSCRSGYVIQGSSDLICTEKGVWSQPYP 3115
                 C   P  PN   +  +  + +    I YSC  GY++ G + L+CT +G WSQP P
Sbjct: 905  KAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAP 964

Query: 3116 VCEPLSCGSP---PSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPE 3172
             C+ ++C SP     +   +   + + Y + V L C +GY ++    +  CQ D +W P 
Sbjct: 965  HCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQS-QCQSDHQWNPP 1023

Query: 3173 RISC 3176
               C
Sbjct: 1024 LAVC 1027



 Score =  360 bits (924), Expect = 1e-98
 Identities = 301/1040 (28%), Positives = 436/1040 (41%), Gaps = 133/1040 (12%)

Query: 2491 PTCKAIECLKPKEILNGKFSY--TDLHYGQTVTYSCNRGFRLEGPSALTCLET----GDW 2544
            P    I C  P  ILNG+ SY  T +  G  + YSC+  FRL G  +L C+      G W
Sbjct: 16   PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75

Query: 2545 DVDAPSCNAI--HCDSPQPIENGFVE---GADYSYGAIIIYSCFPGFQVAGHAMQTCEES 2599
            D  AP C     +   P+PI  G  +      Y +G  + ++C   F + G+    C+ +
Sbjct: 76   DKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135

Query: 2600 G-WSSS-IPTCM---PIDCGLPPHIDFGDCTK-------------LKDDQGYF---EQED 2638
              W  + +PTC+   P++C   P I  G  T                 + GY    E+  
Sbjct: 136  NMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKII 195

Query: 2639 DMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLI 2698
            + +     +  PP    A  K+                 G   ++ C+ GY L G P   
Sbjct: 196  NCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSR 255

Query: 2699 CQEDG---TWNGSAPSCISIECDLPTAPENGFL---RFTETSMGSAVQYSCKP------G 2746
            C   G    W    P C  I C  P    NG          S GS V Y+C P       
Sbjct: 256  CVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314

Query: 2747 HILAG-SDLRLCLENRK---WSGASPRCE----AISCKKPNPVMNGSIKGSN--YTYLST 2796
             IL G S LR  ++++K   WSG +PRCE    A+ C  P  +    + G    YTY  T
Sbjct: 315  FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDT 374

Query: 2797 LYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQ------VRGDEYT 2850
            + + C  G+ L G+++  C     W+   P+C   +C +PP   NGQ      VR D  T
Sbjct: 375  VIFACMFGFTLKGSKQIRCNAQGTWEPSAPVC-EKECQAPPNILNGQKEDRHMVRFDPGT 433

Query: 2851 FQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRC-ATPPQLANGVTEGLDYGF 2909
                I+Y+CN G++L G  S  C + G W+   P C    C AT  QL   +T+      
Sbjct: 434  ---SIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQL---LTKPQHQFV 487

Query: 2910 MKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFS---FI 2966
              +V   C EGY L G+    CQ    W  EI LCK + C PP  + +G   G S   F 
Sbjct: 488  RPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFP 547

Query: 2967 HGGHIQYQCFPG------YKLHGNSSRRCLSN----GSWSGSSPSC----LPCRCSTPVI 3012
            +G  + Y C PG      + L G S+ RC SN    G+WSG +P C    L  +CS   I
Sbjct: 548  YGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHI 607

Query: 3013 EYG-TVNGTD--FDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPM 3069
              G  ++G +  +        +C+ GF L G S+I C+AD  W    P CE   C S P 
Sbjct: 608  ANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEK-GCQSPPG 666

Query: 3070 IPNA---------FISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPL 3120
            + +          F+S  +      + Y+C  GY++ G+  + C   G WS   P CE  
Sbjct: 667  LHHGRHTGGNTVFFVSGMT------VDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEE- 719

Query: 3121 SCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQ--KDGRWFPERISCSP 3178
            +C     V  ++    A +    V   C +GY + T      CQ  ++G WF +   C  
Sbjct: 720  TC---QHVRQSLQELPAGSRVELVNTSCQDGYQL-TGHAYQMCQDAENGIWFKKIPLCKV 775

Query: 3179 KKC---PLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLD----GTWEPPF 3231
              C   P+  N  H  +  ++F    +VS  C +G+   G     C+ D    G+W  P 
Sbjct: 776  IHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS 835

Query: 3232 SDESCSP--VSCGKPESPEHGFVVG---SKYTFESTIIYQCEPGYELEGNRERVCQENRQ 3286
                 SP    C  PE  +HG+ +    S Y+    +   C PG+ + G+R   C  +  
Sbjct: 836  PQCLRSPPVTRCPNPEV-KHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT 894

Query: 3287 WSGGVAICKETR---CETPLEFLNGK---ADIENRTTGPNVVYSCNRGYSLEGPSEAHCT 3340
            W  GV  C +     C  P +  NG     +I   + G +++YSC++GY L G +   CT
Sbjct: 895  WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCT 954

Query: 3341 ENGTWSHPVPLCKPNPCPVPFVIP--ENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC 3398
              GTWS P P CK   C  P  +   +  L   K +     V+++C +G++L+G     C
Sbjct: 955  HEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQC 1014

Query: 3399 NPDETWTQTSAKCEKISCGP 3418
              D  W    A C   S  P
Sbjct: 1015 QSDHQWNPPLAVCRSRSLAP 1034



 Score =  356 bits (913), Expect = 3e-97
 Identities = 283/1040 (27%), Positives = 420/1040 (40%), Gaps = 143/1040 (13%)

Query: 1787 IKCKAPGNPENGHSS--GEIYTVGAEVTFSCQEGYQLMGVTKITCLES----GEWNHLIP 1840
            I C +P    NG  S       VG  + +SC   ++L+G   + C+      G W+   P
Sbjct: 21   ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80

Query: 1841 YC----KAVSCGKPAIPENGCIE-ELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSH 1895
             C    K  SC +P +P    I     +  G  VT+ C   +++ G+K   C AN+ W  
Sbjct: 81   KCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140

Query: 1896 SP-PVCE---PVKCSSPENINNGKYILSGLTYLS---TASYSCDTGYSLQGPSIIECTAS 1948
            +  P C    P++C +   I+NG +    +  ++   + +YSC++GY L G  II C +S
Sbjct: 141  TRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSS 200

Query: 1949 GIWDRAPPACHLVFCG-----------EPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAG 1997
            G W   PP C    C            EPP ++  V          T  + C EGY L G
Sbjct: 201  GKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGV----------TANFFCDEGYRLQG 250

Query: 1998 LDTIECLADGK---WSRSDQQCLAVSCDEPPIV---DHASPETAHRLFGDIAFYYCSD-- 2049
              +  C+  G+   W++    C  + C  PP +    H     A+  +G I  Y C    
Sbjct: 251  PPSSRCVIAGQGVAWTKMPV-CEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDP 309

Query: 2050 ----GYSLADNSQLLCNAQGKWVPPEGQDMPRC----IAHFCEKPPSVSYSILESVSKAK 2101
                 + L   S L C    +         PRC     A  C  P  +    + S  K +
Sbjct: 310  EEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHP-QILRGRMVSGQKDR 368

Query: 2102 FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSN 2161
            +     V F CM GF L  S +I C   G W PS    +     C  PP+I+NG     +
Sbjct: 369  YTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE---KECQAPPNILNGQKEDRH 425

Query: 2162 ---YSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHT 2218
               +  G  + YSCN G+ + GE+   C + G W+ P+P C   +C    +     L   
Sbjct: 426  MVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQ---LLTKP 482

Query: 2219 TGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKG- 2277
              +    +V   C  GYK  GS    CQ    W  E  L C  + C  PP I NG   G 
Sbjct: 483  QHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRL-CKEITCPPPPVIYNGAHTGS 541

Query: 2278 --ENFEVGSKVQFFCNEG------YELVGDSSWTC----QKSGKWNKKSNPKC----MPA 2321
              E+F  G+ V + CN G      + L+G+S+  C    Q+ G W+  + P C    +  
Sbjct: 542  SLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPA-PLCKLSLLAV 600

Query: 2322 KCPEPPLLENQLVLKELTTEV--GVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIV 2379
            +C    +     +  +         VTF C  G  L+G S ++C     W+   PVC+  
Sbjct: 601  QCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKG 660

Query: 2380 LCTPPPLISFGVPIPSSALHF--GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVP 2437
             C  PP +  G     + + F  G TV Y+C  G+ L GN +  C P G WS   P C  
Sbjct: 661  -CQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEE 719

Query: 2438 VECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLC--GENGHWLGGKPTCKA 2495
              C   + +   + ++   + +     +C+ G++L G+   +C   ENG W    P CK 
Sbjct: 720  T-C---QHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKV 775

Query: 2496 IECLKPKEILNGKFS---YTDLHYGQTVTYSCNRGFRLEGPSALTCLET----GDWDVDA 2548
            I C  P  I+NGK +     +  YG  V+Y C++GF L G   L C       G W   +
Sbjct: 776  IHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS 835

Query: 2549 PSC----NAIHCDSPQPIENGFVEG---ADYSYGAIIIYSCFPGFQVAGHAMQTCE-ESG 2600
            P C        C +P+ +++G+      + YS+  I+   C PGF + G  +  C  ++ 
Sbjct: 836  PQCLRSPPVTRCPNPE-VKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT 894

Query: 2601 WSSSIPTCMP---IDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAV 2657
            W   +PTC+    I C  PP    G+ T      G   +    M + Y        +G  
Sbjct: 895  WVPGVPTCIKKAFIGCPPPPKTPNGNHTG-----GNIARFSPGMSILYSCDQGYLLVGEA 949

Query: 2658 AK--TWENTKESPATHSSN---------------------FLYGTMVSYTCNPGYELLGN 2694
                T E T   PA H                        + YG +V+  C  GY L G+
Sbjct: 950  LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGS 1009

Query: 2695 PVLICQEDGTWNGSAPSCIS 2714
            P   CQ D  WN     C S
Sbjct: 1010 PQSQCQSDHQWNPPLAVCRS 1029



 Score =  336 bits (862), Expect = 2e-91
 Identities = 286/1025 (27%), Positives = 409/1025 (39%), Gaps = 150/1025 (14%)

Query: 2548 APSCNAIHCDSPQPIENGFVE--GADYSYGAIIIYSCFPGFQVAGHAMQTC-----EESG 2600
            AP    I C SP PI NG +       + G +I YSC   F++ G     C      +  
Sbjct: 15   APGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGT 74

Query: 2601 WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKT 2660
            W    P C   +        +  C +     GY                           
Sbjct: 75   WDKPAPKCEYFN-------KYSSCPEPIVPGGY--------------------------- 100

Query: 2661 WENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGS-APSCISI---E 2716
                       S+ + +G  V++ C   + + GN  + CQ +  W  +  P+C+S+   E
Sbjct: 101  -------KIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLE 153

Query: 2717 CDLPTAPENGFLRFTETSMGS-----AVQYSCKPGHILAGSDLRLCLENRKWSGASPRCE 2771
            C       NG    T  ++GS     +V YSC+ G++L G  +  CL + KWS   P CE
Sbjct: 154  CPALPMIHNG--HHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCE 211

Query: 2772 AISCKKPNPVMNGSIKGSNYTYLS-TLYYECDPGYVLNGTERRTC---QDDKNWDEDEPI 2827
               CK      NG +K      +  T  + CD GY L G     C        W +  P+
Sbjct: 212  EARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK-MPV 270

Query: 2828 CIPVDCSSPPVSANGQVRGD---EYTFQKEIEYTCN----EG--FLLEGARSRVCLAN-- 2876
            C  + C SPP   NG+  G+     ++   + YTC+    EG  F+L G  +  C  +  
Sbjct: 271  CEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQ 330

Query: 2877 --GSWSGATPDC----VPVRCATPPQLANGVTEGLD--YGFMKEVTFHCHEGYILHGAPK 2928
              G+WSG  P C      V+C  P  L   +  G    Y +   V F C  G+ L G+ +
Sbjct: 331  KTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQ 390

Query: 2929 LTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNG---FSFIHGGHIQYQCFPGYKLHGNS 2985
            + C + G W+   P+C+   C  P ++ +G         F  G  I+Y C PGY L G  
Sbjct: 391  IRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEE 449

Query: 2986 SRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEIT 3045
            S +C S G W+   P C    C     +  T     F         C +G+KL G     
Sbjct: 450  SIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQF-VRPDVNSSCGEGYKLSGSVYQE 508

Query: 3046 CEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKEN-----VITYSCRSG------Y 3094
            C+    W      C+  +C   P+I N   + T S  E+      +TY+C  G      +
Sbjct: 509  CQGTIPWFMEIRLCKEITCPPPPVIYNG--AHTGSSLEDFPYGTTVTYTCNPGPERGVEF 566

Query: 3095 VIQGSSDLICT----EKGVWSQPYPVCE----PLSCGSPPSVANA--VATGEA-HTYESE 3143
             + G S + CT    E+G WS P P+C+     + C S   +AN   ++  EA + Y   
Sbjct: 567  SLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQC-SHVHIANGYKISGKEAPYFYNDT 625

Query: 3144 VKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDD---FSVN 3200
            V  +C  G+T+   +    C+ D  W PE   C  K C  P  + H    G +   F   
Sbjct: 626  VTFKCYSGFTL-KGSSQIRCKADNTWDPEIPVCE-KGCQSPPGLHHGRHTGGNTVFFVSG 683

Query: 3201 RQVSVSCAEGYTFEGVNISVCQLDGTWEP--PFSDESCSPVSCGKPESPEHGFVVGSKYT 3258
              V  +C  GY   G     C   G W P  P  +E+C  V     E P      GS+  
Sbjct: 684  MTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEETCQHVRQSLQELP-----AGSRVE 738

Query: 3259 FESTIIYQCEPGYELEGNRERVCQ--ENRQWSGGVAICKETRCETPLEFLNGKAD---IE 3313
              +T    C+ GY+L G+  ++CQ  EN  W   + +CK   C  P   +NGK      E
Sbjct: 739  LVNT---SCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAE 795

Query: 3314 NRTTGPNVVYSCNRGYSLEGPSEAHCTE----NGTWSHPVPLCKPNP----CPVPFVIPE 3365
            N   G  V Y C++G+ L G  +  C      +G+WS P P C  +P    CP P V   
Sbjct: 796  NFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHG 855

Query: 3366 NALLSEKEFYVDQN-VSIKCREGFLLQGHGIITCNPDETWTQTSAKCEK---ISCGPPAH 3421
              L      Y   + V + C  GF++ G  +I C+ D TW      C K   I C PP  
Sbjct: 856  YKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPK 915

Query: 3422 VENAIARG---VHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSP-PICRAV-CRFPC 3476
              N    G     +  G  I YSC  GY+L G    +C   GTW+ P P C+ V C  P 
Sbjct: 916  TPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPA 975

Query: 3477 QNGGI 3481
               GI
Sbjct: 976  DMDGI 980



 Score =  327 bits (838), Expect = 1e-88
 Identities = 259/966 (26%), Positives = 397/966 (41%), Gaps = 124/966 (12%)

Query: 1629 SDCP--------RLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQ 1680
            S CP        ++ GS P+        + G  V   C   F + GN   +C     W  
Sbjct: 89   SSCPEPIVPGGYKIRGSTPY--------RHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140

Query: 1681 P-LPHCERI---SCGVPPPLENGFHSADDFYA---GSTVTYQCNNGYYLLGDSRMFCTDN 1733
              LP C  +    C   P + NG H++++  +   G +VTY C +GY L+G+  + C  +
Sbjct: 141  TRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSS 200

Query: 1734 GSWNGVSPSCLDVDECAVGSDCSEHAS-----CLNVDGSYICS------------CVPPY 1776
            G W+ V P+C +    ++G   +          + V  ++ C             CV   
Sbjct: 201  GKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCV--I 258

Query: 1777 TGDG-----KNCAEPIKCKAPGNPENGHSSGEI---YTVGAEVTFSC----QEG--YQLM 1822
             G G         E I C +P    NG   G      + G+ VT++C    +EG  + L+
Sbjct: 259  AGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILI 318

Query: 1823 GVTKITCL----ESGEWNHLIPYCK----AVSCGKPAIPENGCI--EELAFTFGSKVTYR 1872
            G + + C     ++G W+   P C+    AV C  P I     +  ++  +T+   V + 
Sbjct: 319  GESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFA 378

Query: 1873 CNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYL---STASY 1929
            C  G+TL G K+  C A  +W  S PVCE  +C +P NI NG+     +      ++  Y
Sbjct: 379  CMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKEDRHMVRFDPGTSIKY 437

Query: 1930 SCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTF-RNTVTYT 1988
            SC+ GY L G   I+CT+ G+W    P C +  C    A    ++T     F R  V  +
Sbjct: 438  SCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAAC---EATGRQLLTKPQHQFVRPDVNSS 494

Query: 1989 CKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIV---DHASPETAHRLFGDIAFY 2045
            C EGY L+G    EC     W    + C  ++C  PP++    H         +G    Y
Sbjct: 495  CGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTY 554

Query: 2046 YCSDG------YSLADNSQLLCNA----QGKWVPPEGQDMPRCIAHFCEKPPSVSYSILE 2095
             C+ G      +SL   S + C +    +G W  P        +A  C     ++     
Sbjct: 555  TCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH-VHIANGYKI 613

Query: 2096 SVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNG 2155
            S  +A +     V+FKC  GF L  S++I C     W+P    I      C  PP + +G
Sbjct: 614  SGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDP---EIPVCEKGCQSPPGLHHG 670

Query: 2156 YASGSNYSF---GAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVEN 2212
              +G N  F   G  V Y+C+ G+ + G K   C  +G WS   P C          V  
Sbjct: 671  RHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEETC----QHVRQ 726

Query: 2213 GFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQ--ANRHWHSESPLMCVPLDCGKPPPI 2270
               E   G   E  V   C  GY+  G    +CQ   N  W  + PL C  + C  PP I
Sbjct: 727  SLQELPAGSRVEL-VNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPL-CKVIHCHPPPVI 784

Query: 2271 QNG---FMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKS----GKWNKKSNPKCMPA-- 2321
             NG    M  ENF  G++V + C++G+ L+G+    C+      G W+  S P+C+ +  
Sbjct: 785  VNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS-PQCLRSPP 843

Query: 2322 --KCPEPPLLENQLVLK--ELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVC- 2376
              +CP P +     + K     +   +V   C  G ++ G  V++C     W    P C 
Sbjct: 844  VTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCI 903

Query: 2377 --KIVLCTPPPLISFGVPIPSSALHF--GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPL 2432
                + C PPP    G     +   F  G ++ YSC  G+ L G +  LC  +GTWS P 
Sbjct: 904  KKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPA 963

Query: 2433 PECVPVECPQPEE---IPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGG 2489
            P C  V C  P +   I  G+   +   Y +     C+ G+ L G+  + C  +  W   
Sbjct: 964  PHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPP 1023

Query: 2490 KPTCKA 2495
               C++
Sbjct: 1024 LAVCRS 1029



 Score =  283 bits (725), Expect = 2e-75
 Identities = 235/895 (26%), Positives = 355/895 (39%), Gaps = 156/895 (17%)

Query: 1625 SIFCSDCPRLG--GSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPL 1682
            S+F  +CP L    +  H       + PG  V   C+ G+ LVG  +  CL+ G+W+   
Sbjct: 148  SVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVP 207

Query: 1683 PHCERISCGVPPPLENG-FHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNG---SWNG 1738
            P CE   C       NG          G T  + C+ GY L G     C   G   +W  
Sbjct: 208  PTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK 267

Query: 1739 VSPSCLDV------------------DECAVGS--------DCSEHASCLNVDGSYICSC 1772
            + P C ++                     + GS        D  E  + + +  S +   
Sbjct: 268  M-PVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCT 326

Query: 1773 VP-----PYTGDGKNC---AEPIKCKAPGNPENGHSSG--EIYTVGAEVTFSCQEGYQLM 1822
            V       ++G    C      ++C  P        SG  + YT    V F+C  G+ L 
Sbjct: 327  VDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLK 386

Query: 1823 GVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEE---LAFTFGSKVTYRCNKGYTL 1879
            G  +I C   G W    P C+   C  P    NG  E+   + F  G+ + Y CN GY L
Sbjct: 387  GSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVL 445

Query: 1880 AGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTY---LSTASYSCDTGYS 1936
             G++   C +   W+   P C+   C +      G+ +L+   +       + SC  GY 
Sbjct: 446  VGEESIQCTSEGVWTPPVPQCKVAACEA-----TGRQLLTKPQHQFVRPDVNSSCGEGYK 500

Query: 1937 LQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGN---NFTFRNTVTYTCKEG- 1992
            L G    EC  +  W      C  + C  PP I +   TG+   +F +  TVTYTC  G 
Sbjct: 501  LSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGP 560

Query: 1993 -----YTLAGLDTIECLAD----GKWSRSDQQC----LAVSCDEPPIVD--HASPETAHR 2037
                 ++L G  TI C ++    G WS     C    LAV C    I +    S + A  
Sbjct: 561  ERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPY 620

Query: 2038 LFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESV 2097
             + D   + C  G++L  +SQ+ C A   W P    ++P C    C+ PP + +      
Sbjct: 621  FYNDTVTFKCYSGFTLKGSSQIRCKADNTWDP----EIPVC-EKGCQSPPGLHHGRHTGG 675

Query: 2098 SKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSP-----------MSIQCIP--- 2143
            +   F +G  V + C  G++L  +  I CM  G W+PS             S+Q +P   
Sbjct: 676  NTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEETCQHVRQSLQELPAGS 735

Query: 2144 ----------------------------------------VRCGEPPSIMNGYASG---S 2160
                                                    + C  PP I+NG  +G    
Sbjct: 736  RVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAE 795

Query: 2161 NYSFGAMVAYSCNKGFYIKGEKKSTCEAT----GQWSSPIPTC---HPVSCGEPPKVENG 2213
            N+ +G  V+Y C++GFY+ GEKK  C +     G WS P P C    PV+    P+V++G
Sbjct: 796  NFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHG 855

Query: 2214 F-LEHTTGRIFESEVRY-QCNPGYKSVGSPVFVCQANRHWHSESPLMCVP---LDCGKPP 2268
            + L  T      +++ Y  CNPG+   GS V  C  +  W    P  C+    + C  PP
Sbjct: 856  YKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVP-TCIKKAFIGCPPPP 914

Query: 2269 PIQNGFMKGEN---FEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPE 2325
               NG   G N   F  G  + + C++GY LVG++   C   G W++ + P C    C  
Sbjct: 915  KTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPA-PHCKEVNCSS 973

Query: 2326 P---PLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCK 2377
            P     ++  L  +++     VVT  C++G++L+G    +C    QWN    VC+
Sbjct: 974  PADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCR 1028



 Score = 80.9 bits (198), Expect = 2e-14
 Identities = 66/237 (27%), Positives = 98/237 (41%), Gaps = 44/237 (18%)

Query: 362 CREGYRASGQ------------------TCELVHCPALKPPENGYFIQNTCNN-HFNAAC 402
           C EGYR  G                    CE + CP+  P  NG  I N+  N  + +  
Sbjct: 242 CDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIV 301

Query: 403 GVRCHP------GFDLVGSSIILCLPN----GLWSGSESYCRVRT----CPHLRQPKHGH 448
              C P       F L+G S + C  +    G WSG    C + T    CPH +  +   
Sbjct: 302 TYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRM 361

Query: 449 ISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVI 508
           +S       Y  T + AC  G+ L+GS ++ C     W+   P C E+ C   Q P + I
Sbjct: 362 VSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVC-EKEC---QAPPN-I 416

Query: 509 ISPHNCGKQPAKF--GTICYVSCRQGFILSGVKEMLRCTTSGKWNVGV---QAAVCK 560
           ++     +   +F  GT    SC  G++L G +E ++CT+ G W   V   + A C+
Sbjct: 417 LNGQKEDRHMVRFDPGTSIKYSCNPGYVLVG-EESIQCTSEGVWTPPVPQCKVAACE 472



 Score = 75.9 bits (185), Expect = 7e-13
 Identities = 77/301 (25%), Positives = 110/301 (36%), Gaps = 56/301 (18%)

Query: 307 CEKGYYGKGL-QYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPG------------ 353
           C  G+  KG  Q  C A    T+ PE         IP  ++   SPPG            
Sbjct: 630 CYSGFTLKGSSQIRCKA--DNTWDPE---------IPVCEKGCQSPPGLHHGRHTGGNTV 678

Query: 354 ---STSPEDCVCREGYRASGQTCELVHC-PALKPPENGYFIQNTCNNHFNAA-------- 401
              S    D  C  GY   G   + +HC P+     +    + TC +   +         
Sbjct: 679 FFVSGMTVDYTCDPGYLLVGN--KSIHCMPSGNWSPSAPRCEETCQHVRQSLQELPAGSR 736

Query: 402 ---CGVRCHPGFDLVGSSIILC--LPNGLWSGSESYCRVRTCPHLRQPKHG-HISCSTRE 455
                  C  G+ L G +  +C    NG+W      C+V  C       +G H       
Sbjct: 737 VELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAEN 796

Query: 456 MLYKTTCLVACDEGYRLEGSDKLTC----QGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
            LY       CD+G+ L G  KL C    +G+  W GP P+C+ R     + P   +   
Sbjct: 797 FLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL-RSPPVTRCPNPEVKHG 855

Query: 512 HNCGKQPAKF--GTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINC 569
           +   K  + +    I YV C  GFI++G   ++RC T   W  GV   + K      I C
Sbjct: 856 YKLNKTHSAYSHNDIVYVDCNPGFIMNG-SRVIRCHTDNTWVPGVPTCIKKAF----IGC 910

Query: 570 P 570
           P
Sbjct: 911 P 911



 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 72/286 (25%), Positives = 107/286 (37%), Gaps = 54/286 (18%)

Query: 307 CEKGYYGKGLQ-YECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDC--VCR 363
           C  GY   G +  +CT+   G + P      +++C     +  T P       D    C 
Sbjct: 439 CNPGYVLVGEESIQCTS--EGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCG 496

Query: 364 EGYRASGQT----------------CELVHCPALKPPENGYFIQNTCNNH-FNAACGVRC 406
           EGY+ SG                  C+ + CP      NG    ++  +  +       C
Sbjct: 497 EGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTC 556

Query: 407 HPG------FDLVGSSIILCLPN----GLWSGSESYCRVRT----CPHLRQPKHGHISCS 452
           +PG      F L+G S I C  N    G WSG    C++      C H+       IS  
Sbjct: 557 NPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGK 616

Query: 453 TREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPH 512
                Y  T    C  G+ L+GS ++ C+ ++ WD   P C E+ C   Q P  +    H
Sbjct: 617 EAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVC-EKGC---QSPPGLHHGRH 672

Query: 513 NCGKQPAKFGTICYVS-------CRQGFILSGVKEMLRCTTSGKWN 551
             G       T+ +VS       C  G++L G K  + C  SG W+
Sbjct: 673 TGG------NTVFFVSGMTVDYTCDPGYLLVGNKS-IHCMPSGNWS 711



 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 74/292 (25%), Positives = 108/292 (36%), Gaps = 60/292 (20%)

Query: 297  GTHTGHFECICEKGYYGKGLQYECTA-----------CPSGTYKPEGSPGGIS-SCIPCP 344
            G HTG    + E   YG  + YEC             C S + K  GS  G S  C+   
Sbjct: 787  GKHTG---MMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDS-KGHGSWSGPSPQCL--- 839

Query: 345  DENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGV 404
                 SPP +  P   V + GY+ +       H                     N    V
Sbjct: 840  ----RSPPVTRCPNPEV-KHGYKLNKTHSAYSH---------------------NDIVYV 873

Query: 405  RCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTC----PHLRQPKHGHISCSTREMLYKT 460
             C+PGF + GS +I C  +  W      C  +      P  + P   H   +        
Sbjct: 874  DCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGM 933

Query: 461  TCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAK 520
            + L +CD+GY L G   L C     W  P P C E +CS+   P D  +     G +P K
Sbjct: 934  SILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSS---PAD--MDGIQKGLEPRK 988

Query: 521  ---FGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINC 569
               +G +  + C  G++L G  +  +C +  +WN  +  AVC+      + C
Sbjct: 989  MYQYGAVVTLECEDGYMLEGSPQS-QCQSDHQWNPPL--AVCRSRSLAPVLC 1037



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 57/194 (29%), Positives = 80/194 (41%), Gaps = 27/194 (13%)

Query: 376 VHCPALKPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSGSES 431
           + CPAL    NG+   +T  N  + A G+     C  G+ LVG  II CL +G WS    
Sbjct: 152 LECPALPMIHNGH---HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPP 208

Query: 432 YCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEG--SDKLTCQGNSQWDGP 489
            C    C  L +  +G +      +    T    CDEGYRL+G  S +    G       
Sbjct: 209 TCEEARCKSLGRFPNGKVK-EPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK 267

Query: 490 EPRCVERHCSTFQMPKDVIISPHNCGKQPA--KFGTICYVSCRQ------GFILSGVKEM 541
            P C E  C +       I++  + G   A   +G+I   +C         FIL G +  
Sbjct: 268 MPVCEEIFCPS----PPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIG-EST 322

Query: 542 LRCTT----SGKWN 551
           LRCT     +G W+
Sbjct: 323 LRCTVDSQKTGTWS 336



 Score = 55.5 bits (132), Expect = 1e-06
 Identities = 45/195 (23%), Positives = 74/195 (37%), Gaps = 15/195 (7%)

Query: 378 CPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRT 437
           CP    P  GY I+ +       +    C   F + G+  + C  N +W  +     V  
Sbjct: 91  CPEPIVP-GGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSV 149

Query: 438 ----CPHLRQPKHG-HISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPR 492
               CP L    +G H S +   +    +   +C+ GY L G   + C  + +W    P 
Sbjct: 150 FPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT 209

Query: 493 CVERHCSTFQMPKDVIISPHNCGKQP--AKFGTICYVSCRQGFILSGVKEMLRCTTSGKW 550
           C E  C      K +   P+   K+P   + G      C +G+ L G     RC  +G+ 
Sbjct: 210 CEEARC------KSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSS-RCVIAGQG 262

Query: 551 NVGVQAAVCKDVEAP 565
               +  VC+++  P
Sbjct: 263 VAWTKMPVCEEIFCP 277



 Score = 52.4 bits (124), Expect = 8e-06
 Identities = 44/161 (27%), Positives = 66/161 (40%), Gaps = 22/161 (13%)

Query: 406 CHPGFDLVGSSIILCLP----NGLWSGSESYC----RVRTCPHLRQPKHGHISCSTREML 457
           C   F L+G   +LC+     +G W      C    +  +CP    P    I  ST    
Sbjct: 51  CSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGST-PYR 109

Query: 458 YKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPE--PRCVERHCSTFQMPKDVIISPHNCG 515
           +  +   AC   + + G+  + CQ N+ W GP   P CV    S F +    +   HN  
Sbjct: 110 HGDSVTFACKTNFSMNGNKSVWCQANNMW-GPTRLPTCV----SVFPLECPALPMIHNGH 164

Query: 516 KQPAKFGTIC-----YVSCRQGFILSGVKEMLRCTTSGKWN 551
                 G+I        SC  G++L G K ++ C +SGKW+
Sbjct: 165 HTSENVGSIAPGLSVTYSCESGYLLVGEK-IINCLSSGKWS 204



 Score = 36.6 bits (83), Expect = 0.46
 Identities = 26/110 (23%), Positives = 45/110 (40%), Gaps = 7/110 (6%)

Query: 446 HGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC----QGNSQWDGPEPRCVERHCSTF 501
           +G IS  +  +   T    +C   +RL G   L C    + +  WD P P+C E      
Sbjct: 31  NGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC-EYFNKYS 89

Query: 502 QMPKDVIISPHNC-GKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKW 550
             P+ ++   +   G  P + G     +C+  F ++G K +  C  +  W
Sbjct: 90  SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVW-CQANNMW 138


>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
            isoform 2 [Homo sapiens]
          Length = 1033

 Score =  372 bits (954), Expect = e-102
 Identities = 290/1015 (28%), Positives = 428/1015 (42%), Gaps = 142/1015 (13%)

Query: 1688 ISCGVPPPLENGFHS--ADDFYAGSTVTYQCNNGYYLLGDSRMFCTD----NGSWNGVSP 1741
            ISCG PPP+ NG  S  +     G+ + Y C+  + L+G+  + C      +G+W+  +P
Sbjct: 21   ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80

Query: 1742 SCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSS 1801
             C                                Y     +C EPI    PG  +   S+
Sbjct: 81   KC-------------------------------EYFNKYSSCPEPI---VPGGYKIRGST 106

Query: 1802 GEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHL-IPYCKAV---SCGKPAIP--EN 1855
               Y  G  VTF+C+  + + G   + C  +  W    +P C +V    C  PA+P   N
Sbjct: 107  P--YRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLEC--PALPMIHN 162

Query: 1856 G--CIEEL-AFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENIN 1912
            G    E + +   G  VTY C  GY L G+K  +CL++  WS  PP CE  +C S     
Sbjct: 163  GHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFP 222

Query: 1913 NGKYILSGLTYLS-TASYSCDTGYSLQGPSIIECTASG---IWDRAPPACHLVFCGEPPA 1968
            NGK     +  +  TA++ CD GY LQGP    C  +G    W +  P C  +FC  PP 
Sbjct: 223  NGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKM-PVCEEIFCPSPPP 281

Query: 1969 IKDAVITGN---NFTFRNTVTYTC----KEG--YTLAGLDTIECLAD----GKWSRSDQQ 2015
            I +    GN   N ++ + VTYTC    +EG  + L G  T+ C  D    G WS    +
Sbjct: 282  ILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPR 341

Query: 2016 C----LAVSCDEPPIV--DHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVP 2069
            C     AV C  P I+     S +     + D   + C  G++L  + Q+ CNAQG W P
Sbjct: 342  CELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEP 401

Query: 2070 PEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRG 2129
                  P C    C+ PP++     E     +F  G+ + + C  G+VL     I+C   
Sbjct: 402  ----SAPVCEKE-CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSE 456

Query: 2130 GQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEAT 2189
            G W P P+  QC    C      +       +      V  SC +G+ + G     C+ T
Sbjct: 457  GVWTP-PVP-QCKVAACEATGRQL--LTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGT 512

Query: 2190 GQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRI----FESEVRYQCNPG------YKSVG 2239
              W   I  C  ++C  PP + NG   HT   +    + + V Y CNPG      +  +G
Sbjct: 513  IPWFMEIRLCKEITCPPPPVIYNG--AHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIG 570

Query: 2240 SPVFVCQANRH----WHSESPLMCVPL---DCGKPPPIQNGFM---KGENFEVGSKVQFF 2289
                 C +N      W   +PL  + L    C     I NG+    K   +     V F 
Sbjct: 571  ESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH-VHIANGYKISGKEAPYFYNDTVTFK 629

Query: 2290 CNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSC 2349
            C  G+ L G S   C+    W+ +  P C    C     +   L      + V +V  SC
Sbjct: 630  CYSGFTLKGSSQIRCKADNTWDPEI-PVCEKETCQH---VRQSLQELPAGSRVELVNTSC 685

Query: 2350 KEGHVLQGPSVLKCLPSQQ--WNDSFPVCKIVLCTPPPLISFGVPIPSSALHF--GSTVK 2405
            ++G+ L G +   C  ++   W    P+CK++ C PPP+I  G      A +F  G+ V 
Sbjct: 686  QDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVS 745

Query: 2406 YSCVGGFFLRGNSTTLCQPD----GTWSSPLPECV---PV-ECPQPEEIPNGIIDVQGLA 2457
            Y C  GF+L G     C+ D    G+WS P P+C+   PV  CP PE      ++    A
Sbjct: 746  YECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSA 805

Query: 2458 YLSTAL--YTCKPGFELVGNTTTLCGENGHWLGGKPTC--KA-IECLKPKEILNGKFSYT 2512
            Y    +    C PGF + G+    C  +  W+ G PTC  KA I C  P +  NG  +  
Sbjct: 806  YSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGG 865

Query: 2513 DL---HYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSP---QPIENGF 2566
            ++     G ++ YSC++G+ L G + L C   G W   AP C  ++C SP     I+ G 
Sbjct: 866  NIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGL 925

Query: 2567 VEGADYSYGAIIIYSCFPGFQVAGHAMQTCE-ESGWSSSIPTC-----MPIDCGL 2615
                 Y YGA++   C  G+ + G     C+ +  W+  +  C      P+ CG+
Sbjct: 926  EPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCGI 980



 Score =  342 bits (877), Expect = 4e-93
 Identities = 276/1010 (27%), Positives = 411/1010 (40%), Gaps = 155/1010 (15%)

Query: 1632 PRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQ----GQWTQPLPHCER 1687
            P L G + +  T    +  G+ +   C   F+L+G     C+ +    G W +P P CE 
Sbjct: 28   PILNGRISYYSTP---IAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEY 84

Query: 1688 IS--CGVPPPLENG---FHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVS-P 1741
             +     P P+  G      +  +  G +VT+ C   + + G+  ++C  N  W     P
Sbjct: 85   FNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLP 144

Query: 1742 SCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSS 1801
            +C+ V                                       P++C A     NGH +
Sbjct: 145  TCVSV--------------------------------------FPLECPALPMIHNGHHT 166

Query: 1802 GE---IYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCI 1858
             E       G  VT+SC+ GY L+G   I CL SG+W+ + P C+   C       NG +
Sbjct: 167  SENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKV 226

Query: 1859 EE-LAFTFGSKVTYRCNKGYTLAGDKESSCL---ANSSWSHSPPVCEPVKCSSPENINNG 1914
            +E      G    + C++GY L G   S C+      +W+   PVCE + C SP  I NG
Sbjct: 227  KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNG 285

Query: 1915 KYI---LSGLTYLSTASYSCD------TGYSLQGPSIIECTA----SGIWDRAPPACHL- 1960
            ++I   L+ ++Y S  +Y+CD        + L G S + CT     +G W    P C L 
Sbjct: 286  RHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELS 345

Query: 1961 ---VFCGEPPAIKDAVITG--NNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQ 2015
               V C  P  ++  +++G  + +T+ +TV + C  G+TL G   I C A G W  S   
Sbjct: 346  TSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPV 405

Query: 2016 CLAVSCDEPPIVDHASPETAHRLF---GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEG 2072
            C    C  PP + +   E  H +    G    Y C+ GY L     + C ++G W PP  
Sbjct: 406  C-EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPP-- 462

Query: 2073 QDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQW 2132
              +P+C    CE     +   L +  + +F    V S  C EG+ L+ S   EC     W
Sbjct: 463  --VPQCKVAACE----ATGRQLLTKPQHQFVRPDVNS-SCGEGYKLSGSVYQECQGTIPW 515

Query: 2133 NPSPMSIQ-CIPVRCGEPPSIMNGYASGS---NYSFGAMVAYSCNKG------FYIKGEK 2182
                M I+ C  + C  PP I NG  +GS   ++ +G  V Y+CN G      F + GE 
Sbjct: 516  F---MEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGES 572

Query: 2183 KSTC----EATGQWSSPIPTCH----PVSCGEPPKVENGFLEHTTGR----IFESEVRYQ 2230
               C    +  G WS P P C      V C     + NG+    +G+     +   V ++
Sbjct: 573  TIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH-VHIANGY--KISGKEAPYFYNDTVTFK 629

Query: 2231 CNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFF- 2289
            C  G+   GS    C+A+  W  E P +C    C      Q+     +    GS+V+   
Sbjct: 630  CYSGFTLKGSSQIRCKADNTWDPEIP-VCEKETC------QHVRQSLQELPAGSRVELVN 682

Query: 2290 --CNEGYELVGDSSWTCQ--KSGKWNKKSNPKCMPAKCPEPPLLENQL---VLKELTTEV 2342
              C +GY+L G +   CQ  ++G W KK  P C    C  PP++ N     ++ E     
Sbjct: 683  TSCQDGYQLTGHAYQMCQDAENGIWFKKI-PLCKVIHCHPPPVIVNGKHTGMMAENFLYG 741

Query: 2343 GVVTFSCKEGHVLQGPSVLKCLPSQQ----WNDSFPVC----KIVLCTPPPLISFGVPI- 2393
              V++ C +G  L G   L+C    +    W+   P C     +  C P P +  G  + 
Sbjct: 742  NEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRC-PNPEVKHGYKLN 800

Query: 2394 -PSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVP---VECPQPEEIPNG 2449
               SA      V   C  GF + G+    C  D TW   +P C+    + CP P + PNG
Sbjct: 801  KTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNG 860

Query: 2450 IIDVQGLAYLS---TALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKE--- 2503
                  +A  S   + LY+C  G+ LVG    LC   G W    P CK + C  P +   
Sbjct: 861  NHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDG 920

Query: 2504 ILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNA 2553
            I  G        YG  VT  C  G+ LEG     C     W+     C +
Sbjct: 921  IQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRS 970



 Score =  334 bits (856), Expect = 1e-90
 Identities = 272/1014 (26%), Positives = 405/1014 (39%), Gaps = 140/1014 (13%)

Query: 2491 PTCKAIECLKPKEILNGKFSY--TDLHYGQTVTYSCNRGFRLEGPSALTCLET----GDW 2544
            P    I C  P  ILNG+ SY  T +  G  + YSC+  FRL G  +L C+      G W
Sbjct: 16   PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75

Query: 2545 DVDAPSCNAI--HCDSPQPIENGFVE---GADYSYGAIIIYSCFPGFQVAGHAMQTCEES 2599
            D  AP C     +   P+PI  G  +      Y +G  + ++C   F + G+    C+ +
Sbjct: 76   DKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135

Query: 2600 G-WSSS-IPTCM---PIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHL 2654
              W  + +PTC+   P++C   P I  G                          H   ++
Sbjct: 136  NMWGPTRLPTCVSVFPLECPALPMIHNGH-------------------------HTSENV 170

Query: 2655 GAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCIS 2714
            G++A                   G  V+Y+C  GY L+G  ++ C   G W+   P+C  
Sbjct: 171  GSIAP------------------GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEE 212

Query: 2715 IECDLPTAPENGFLRFTET-SMGSAVQYSCKPGHILAGSDLRLCL---ENRKWSGASPRC 2770
              C       NG ++      +G    + C  G+ L G     C+   +   W+   P C
Sbjct: 213  ARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVC 271

Query: 2771 EAISCKKPNPVMNGSIKGS---NYTYLSTLYYECDP------GYVLNGTERRTCQDDKN- 2820
            E I C  P P++NG   G+   N +Y S + Y CDP       ++L G     C  D   
Sbjct: 272  EEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQK 331

Query: 2821 ---WDEDEPIC----IPVDCSSPPVSANGQVRG--DEYTFQKEIEYTCNEGFLLEGARSR 2871
               W    P C      V C  P +     V G  D YT+   + + C  GF L+G++  
Sbjct: 332  TGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQI 391

Query: 2872 VCLANGSWSGATPDCVPVRCATPPQLANGVTEG-----LDYGFMKEVTFHCHEGYILHGA 2926
             C A G+W  + P C    C  PP + NG  E       D G    + + C+ GY+L G 
Sbjct: 392  RCNAQGTWEPSAPVCEK-ECQAPPNILNGQKEDRHMVRFDPG--TSIKYSCNPGYVLVGE 448

Query: 2927 PKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSS 2986
              + C S+G W   +P CK   C          P    F+    +   C  GYKL G+  
Sbjct: 449  ESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQ-HQFVRPD-VNSSCGEGYKLSGSVY 506

Query: 2987 RRCLSNGSWSGSSPSCLPCRCSTPVIEY-GTVNGT---DFDCGKAARIQCFKG------F 3036
            + C     W      C    C  P + Y G   G+   DF  G      C  G      F
Sbjct: 507  QECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEF 566

Query: 3037 KLLGLSEITCEAD----GQWSSGFPHCEHT----SCGSLPMIPNAFIS--ETSSWKENVI 3086
             L+G S I C ++    G WS   P C+ +     C  + +     IS  E   +  + +
Sbjct: 567  SLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTV 626

Query: 3087 TYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKL 3146
            T+ C SG+ ++GSS + C     W    PVCE  +C     V  ++    A +    V  
Sbjct: 627  TFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETC---QHVRQSLQELPAGSRVELVNT 683

Query: 3147 RCLEGYTMDTDTDTFTCQ--KDGRWFPERISCSPKKC---PLPENITHILVHGDDFSVNR 3201
             C +GY + T      CQ  ++G WF +   C    C   P+  N  H  +  ++F    
Sbjct: 684  SCQDGYQL-TGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGN 742

Query: 3202 QVSVSCAEGYTFEGVNISVCQLD----GTWEPPFSDESCSP--VSCGKPESPEHGFVVG- 3254
            +VS  C +G+   G     C+ D    G+W  P      SP    C  PE  +HG+ +  
Sbjct: 743  EVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEV-KHGYKLNK 801

Query: 3255 --SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETR---CETPLEFLNGK 3309
              S Y+    +   C PG+ + G+R   C  +  W  GV  C +     C  P +  NG 
Sbjct: 802  THSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGN 861

Query: 3310 ---ADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIP-- 3364
                +I   + G +++YSC++GY L G +   CT  GTWS P P CK   C  P  +   
Sbjct: 862  HTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGI 921

Query: 3365 ENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGP 3418
            +  L   K +     V+++C +G++L+G     C  D  W    A C   S  P
Sbjct: 922  QKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAP 975



 Score =  331 bits (849), Expect = 7e-90
 Identities = 265/972 (27%), Positives = 400/972 (41%), Gaps = 123/972 (12%)

Query: 2262 LDCGKPPPIQNGFMK--GENFEVGSKVQFFCNEGYELVGDSSWTC----QKSGKWNKKSN 2315
            + CG PPPI NG +        VG+ +++ C+  + L+G+ S  C    +  G W+K + 
Sbjct: 21   ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPA- 79

Query: 2316 PKC----MPAKCPEPPLLENQLVLKELTTEVG-VVTFSCKEGHVLQGPSVLKCLPSQQWN 2370
            PKC      + CPEP +     +        G  VTF+CK    + G   + C  +  W 
Sbjct: 80   PKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWG 139

Query: 2371 DS-FPVCKIVL---CTPPPLISFGVPIPSS--ALHFGSTVKYSCVGGFFLRGNSTTLCQP 2424
             +  P C  V    C   P+I  G     +  ++  G +V YSC  G+ L G     C  
Sbjct: 140  PTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLS 199

Query: 2425 DGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLS-TALYTCKPGFELVGNTTTLC--- 2480
             G WS+  P C    C      PNG +    +  +  TA + C  G+ L G  ++ C   
Sbjct: 200  SGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIA 259

Query: 2481 GENGHWLGGKPTCKAIECLKPKEILNGKF---SYTDLHYGQTVTYSCNR------GFRLE 2531
            G+   W    P C+ I C  P  ILNG+    S  ++ YG  VTY+C+        F L 
Sbjct: 260  GQGVAWTK-MPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILI 318

Query: 2532 GPSALTCL----ETGDWDVDAPSC----NAIHCDSPQPIENGFVEGAD--YSYGAIIIYS 2581
            G S L C     +TG W   AP C    +A+ C  PQ +    V G    Y+Y   +I++
Sbjct: 319  GESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFA 378

Query: 2582 CFPGFQVAGHAMQTCEESG-WSSSIPTCMPIDCGLPPHI-------------DFGDCTKL 2627
            C  GF + G     C   G W  S P C   +C  PP+I             D G   K 
Sbjct: 379  CMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKEDRHMVRFDPGTSIKY 437

Query: 2628 KDDQGYFEQEDDMMEVP----YVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSY 2683
              + GY    ++ ++      +  P P   + A     E T     T   +      V+ 
Sbjct: 438  SCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAAC----EATGRQLLTKPQHQFVRPDVNS 493

Query: 2684 TCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSM-----GSA 2738
            +C  GY+L G+    CQ    W      C  I C  P    NG    T +S+     G+ 
Sbjct: 494  SCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNG--AHTGSSLEDFPYGTT 551

Query: 2739 VQYSCKPG------HILAGSDLRLCLENRK----WSGASPRCE----AISCKKPNPVMNG 2784
            V Y+C PG        L G     C  N +    WSG +P C+    A+ C   + + NG
Sbjct: 552  VTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVH-IANG 610

Query: 2785 ---SIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSAN 2841
               S K + Y Y  T+ ++C  G+ L G+ +  C+ D  WD + P+C    C     S  
Sbjct: 611  YKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQ 670

Query: 2842 GQVRGDEYTFQKEIEYTCNEGFLLEGARSRVC--LANGSWSGATPDCVPVRCATPPQLAN 2899
                G        +  +C +G+ L G   ++C    NG W    P C  + C  PP + N
Sbjct: 671  ELPAGSRVEL---VNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVN 727

Query: 2900 GVTEGL---DYGFMKEVTFHCHEGYILHGAPKLTCQSD----GNWDAEIPLC---KPVNC 2949
            G   G+   ++ +  EV++ C +G+ L G  KL C+SD    G+W    P C    PV  
Sbjct: 728  GKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTR 787

Query: 2950 GPPEDLAHGFP---NGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCL--- 3003
             P  ++ HG+       ++ H   +   C PG+ ++G+   RC ++ +W    P+C+   
Sbjct: 788  CPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKA 847

Query: 3004 ----PCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHC 3059
                P    TP   +   N   F  G +    C +G+ L+G + + C  +G WS   PHC
Sbjct: 848  FIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHC 907

Query: 3060 EHTSCGS---LPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPV 3116
            +  +C S   +  I              V+T  C  GY+++GS    C     W+ P  V
Sbjct: 908  KEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAV 967

Query: 3117 CE-----PLSCG 3123
            C      P+ CG
Sbjct: 968  CRSRSLAPVLCG 979



 Score =  318 bits (816), Expect = 5e-86
 Identities = 269/1014 (26%), Positives = 411/1014 (40%), Gaps = 147/1014 (14%)

Query: 2548 APSCNAIHCDSPQPIENGFVE--GADYSYGAIIIYSCFPGFQVAGHAMQTC-----EESG 2600
            AP    I C SP PI NG +       + G +I YSC   F++ G     C      +  
Sbjct: 15   APGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGT 74

Query: 2601 WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKT 2660
            W    P C   +        +  C +     GY                           
Sbjct: 75   WDKPAPKCEYFN-------KYSSCPEPIVPGGY--------------------------- 100

Query: 2661 WENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSA-PSCISI---E 2716
                       S+ + +G  V++ C   + + GN  + CQ +  W  +  P+C+S+   E
Sbjct: 101  -------KIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLE 153

Query: 2717 CDLPTAPENGFLRFTETSMGS-----AVQYSCKPGHILAGSDLRLCLENRKWSGASPRCE 2771
            C       NG    T  ++GS     +V YSC+ G++L G  +  CL + KWS   P CE
Sbjct: 154  CPALPMIHNG--HHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCE 211

Query: 2772 AISCKKPNPVMNGSIKGSNYTYLS-TLYYECDPGYVLNGTERRTC---QDDKNWDEDEPI 2827
               CK      NG +K      +  T  + CD GY L G     C        W +  P+
Sbjct: 212  EARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK-MPV 270

Query: 2828 CIPVDCSSPPVSANGQVRGD---EYTFQKEIEYTCN----EG--FLLEGARSRVCLAN-- 2876
            C  + C SPP   NG+  G+     ++   + YTC+    EG  F+L G  +  C  +  
Sbjct: 271  CEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQ 330

Query: 2877 --GSWSGATPDC----VPVRCATPPQLANGVTEGLD--YGFMKEVTFHCHEGYILHGAPK 2928
              G+WSG  P C      V+C  P  L   +  G    Y +   V F C  G+ L G+ +
Sbjct: 331  KTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQ 390

Query: 2929 LTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNG---FSFIHGGHIQYQCFPGYKLHGNS 2985
            + C + G W+   P+C+   C  P ++ +G         F  G  I+Y C PGY L G  
Sbjct: 391  IRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEE 449

Query: 2986 SRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEIT 3045
            S +C S G W+   P C    C     +  T     F         C +G+KL G     
Sbjct: 450  SIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQF-VRPDVNSSCGEGYKLSGSVYQE 508

Query: 3046 CEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKEN-----VITYSCRSG------Y 3094
            C+    W      C+  +C   P+I N   + T S  E+      +TY+C  G      +
Sbjct: 509  CQGTIPWFMEIRLCKEITCPPPPVIYNG--AHTGSSLEDFPYGTTVTYTCNPGPERGVEF 566

Query: 3095 VIQGSSDLICT----EKGVWSQPYPVCE----PLSCGSPPSVANA--VATGEA-HTYESE 3143
             + G S + CT    E+G WS P P+C+     + C S   +AN   ++  EA + Y   
Sbjct: 567  SLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQC-SHVHIANGYKISGKEAPYFYNDT 625

Query: 3144 VKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQV 3203
            V  +C  G+T+   +    C+ D  W PE   C  + C         L  G    +   V
Sbjct: 626  VTFKCYSGFTL-KGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVEL---V 681

Query: 3204 SVSCAEGYTFEGVNISVCQ--LDGTWEPPFSDESCSPVSCGKPE---SPEHGFVVGSKYT 3258
            + SC +GY   G    +CQ   +G W        C  + C  P    + +H  ++   + 
Sbjct: 682  NTSCQDGYQLTGHAYQMCQDAENGIWFKKI--PLCKVIHCHPPPVIVNGKHTGMMAENFL 739

Query: 3259 FESTIIYQCEPGYELEGNRERVCQENRQ----WSGGVAICKE----TRCETPLEFLNGKA 3310
            + + + Y+C+ G+ L G ++  C+ + +    WSG    C      TRC  P      K 
Sbjct: 740  YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKL 799

Query: 3311 DIENRTTGPN-VVY-SCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNP---CPVPFVIPE 3365
            +  +     N +VY  CN G+ + G     C  + TW   VP C       CP P   P 
Sbjct: 800  NKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPN 859

Query: 3366 NALLSEK--EFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVE 3423
                      F    ++   C +G+LL G  ++ C  + TW+Q +  C++++C  PA ++
Sbjct: 860  GNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMD 919

Query: 3424 NAIARGVH----YQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCR 3473
              I +G+     YQYG ++T  C  GYMLEG  +S C  +  W +PP+  AVCR
Sbjct: 920  -GIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQW-NPPL--AVCR 969



 Score =  313 bits (802), Expect = 2e-84
 Identities = 265/983 (26%), Positives = 396/983 (40%), Gaps = 136/983 (13%)

Query: 1840 PYCKAVSCGKPAIPENGCIEELA--FTFGSKVTYRCNKGYTLAGDKESSCLA----NSSW 1893
            P    +SCG P    NG I   +     G+ + Y C+  + L G+K   C+     + +W
Sbjct: 16   PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75

Query: 1894 SHSPPVCEPVK--CSSPENINNGKYILSGLT---YLSTASYSCDTGYSLQGPSIIECTAS 1948
                P CE      S PE I  G Y + G T   +  + +++C T +S+ G   + C A+
Sbjct: 76   DKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135

Query: 1949 GIWDRAP-PACHLVFCGEPPAIKDAVITGNNFTFRN--------TVTYTCKEGYTLAGLD 1999
             +W     P C  VF  E PA+   +I   + T  N        +VTY+C+ GY L G  
Sbjct: 136  NMWGPTRLPTCVSVFPLECPALP--MIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEK 193

Query: 2000 TIECLADGKWSRSDQQCLAVSCD-----------EPPIVDHASPETAHRLFGDIAFYYCS 2048
             I CL+ GKWS     C    C            EPPI+            G  A ++C 
Sbjct: 194  IINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILR----------VGVTANFFCD 243

Query: 2049 DGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVV 2108
            +GY L       C   G+ V      MP C   FC  PP +        S A  + GS+V
Sbjct: 244  EGYRLQGPPSSRCVIAGQGVA--WTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIV 301

Query: 2109 SFKC----MEG--FVLNTSAKIEC----MRGGQWN-PSPM-SIQCIPVRCGEPPSIMNGY 2156
            ++ C     EG  F+L   + + C     + G W+ P+P   +    V+C  P  +    
Sbjct: 302  TYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRM 361

Query: 2157 ASGSN--YSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGF 2214
             SG    Y++   V ++C  GF +KG K+  C A G W    P C    C  PP + NG 
Sbjct: 362  VSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQ 420

Query: 2215 LEHTTGRIFE--SEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQN 2272
             E      F+  + ++Y CNPGY  VG     C +   W    P  C    C      + 
Sbjct: 421  KEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVP-QCKVAACEATG--RQ 477

Query: 2273 GFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQ 2332
               K ++  V   V   C EGY+L G     CQ +  W  +    C    CP PP++ N 
Sbjct: 478  LLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIR-LCKEITCPPPPVIYNG 536

Query: 2333 LVLKELTTEVG---VVTFSCKEG------HVLQGPSVLKCLPSQQ----WNDSFPVCKIV 2379
                    +      VT++C  G        L G S ++C  + Q    W+   P+CK+ 
Sbjct: 537  AHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLS 596

Query: 2380 L----CTPPPLIS-FGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPE 2434
            L    C+   + + + +    +   +  TV + C  GF L+G+S   C+ D TW   +P 
Sbjct: 597  LLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPV 656

Query: 2435 CVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLC--GENGHWLGGKPT 2492
            C    C   + +   + ++   + +     +C+ G++L G+   +C   ENG W    P 
Sbjct: 657  CEKETC---QHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPL 713

Query: 2493 CKAIECLKPKEILNGKFS---YTDLHYGQTVTYSCNRGFRLEGPSALTCLET----GDWD 2545
            CK I C  P  I+NGK +     +  YG  V+Y C++GF L G   L C       G W 
Sbjct: 714  CKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWS 773

Query: 2546 VDAPSC----NAIHCDSPQPIENGFVEG---ADYSYGAIIIYSCFPGFQVAGHAMQTCE- 2597
              +P C        C +P+ +++G+      + YS+  I+   C PGF + G  +  C  
Sbjct: 774  GPSPQCLRSPPVTRCPNPE-VKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHT 832

Query: 2598 ESGWSSSIPTCMP---IDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHL 2654
            ++ W   +PTC+    I C  PP    G+ T      G   +    M + Y        +
Sbjct: 833  DNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTG-----GNIARFSPGMSILYSCDQGYLLV 887

Query: 2655 GAVAK--TWENTKESPATHSSN---------------------FLYGTMVSYTCNPGYEL 2691
            G      T E T   PA H                        + YG +V+  C  GY L
Sbjct: 888  GEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYML 947

Query: 2692 LGNPVLICQEDGTWNGSAPSCIS 2714
             G+P   CQ D  WN     C S
Sbjct: 948  EGSPQSQCQSDHQWNPPLAVCRS 970



 Score =  285 bits (729), Expect = 6e-76
 Identities = 236/898 (26%), Positives = 367/898 (40%), Gaps = 166/898 (18%)

Query: 1629 SDCP--------RLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQ 1680
            S CP        ++ GS P+        + G  V   C   F + GN   +C     W  
Sbjct: 89   SSCPEPIVPGGYKIRGSTPY--------RHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140

Query: 1681 P-LPHCERI---SCGVPPPLENGFHSADDFYA---GSTVTYQCNNGYYLLGDSRMFCTDN 1733
              LP C  +    C   P + NG H++++  +   G +VTY C +GY L+G+  + C  +
Sbjct: 141  TRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSS 200

Query: 1734 GSWNGVSPSCLDVDECAVGSDCSEHAS-----CLNVDGSYICS------------CVPPY 1776
            G W+ V P+C +    ++G   +          + V  ++ C             CV   
Sbjct: 201  GKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCV--I 258

Query: 1777 TGDG-----KNCAEPIKCKAPGNPENGHSSGEI---YTVGAEVTFSC----QEG--YQLM 1822
             G G         E I C +P    NG   G      + G+ VT++C    +EG  + L+
Sbjct: 259  AGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILI 318

Query: 1823 GVTKITCL----ESGEWNHLIPYCK----AVSCGKPAIPENGCI--EELAFTFGSKVTYR 1872
            G + + C     ++G W+   P C+    AV C  P I     +  ++  +T+   V + 
Sbjct: 319  GESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFA 378

Query: 1873 CNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYL---STASY 1929
            C  G+TL G K+  C A  +W  S PVCE  +C +P NI NG+     +      ++  Y
Sbjct: 379  CMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAPPNILNGQKEDRHMVRFDPGTSIKY 437

Query: 1930 SCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTF-RNTVTYT 1988
            SC+ GY L G   I+CT+ G+W    P C +  C    A    ++T     F R  V  +
Sbjct: 438  SCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAAC---EATGRQLLTKPQHQFVRPDVNSS 494

Query: 1989 CKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIV---DHASPETAHRLFGDIAFY 2045
            C EGY L+G    EC     W    + C  ++C  PP++    H         +G    Y
Sbjct: 495  CGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTY 554

Query: 2046 YCSDG------YSLADNSQLLCNA----QGKWVPPEGQDMPRCIAHFCEKPPSVSYSILE 2095
             C+ G      +SL   S + C +    +G W  P        +A  C     ++     
Sbjct: 555  TCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH-VHIANGYKI 613

Query: 2096 SVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPS------------PMSIQCIP 2143
            S  +A +     V+FKC  GF L  S++I C     W+P               S+Q +P
Sbjct: 614  SGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELP 673

Query: 2144 -------------------------------------------VRCGEPPSIMNGYASG- 2159
                                                       + C  PP I+NG  +G 
Sbjct: 674  AGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGM 733

Query: 2160 --SNYSFGAMVAYSCNKGFYIKGEKKSTCEAT----GQWSSPIPTC---HPVSCGEPPKV 2210
               N+ +G  V+Y C++GFY+ GEKK  C +     G WS P P C    PV+    P+V
Sbjct: 734  MAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEV 793

Query: 2211 ENGF-LEHTTGRIFESEVRY-QCNPGYKSVGSPVFVCQANRHWHSESPLMCVP---LDCG 2265
            ++G+ L  T      +++ Y  CNPG+   GS V  C  +  W    P  C+    + C 
Sbjct: 794  KHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVP-TCIKKAFIGCP 852

Query: 2266 KPPPIQNGFMKGEN---FEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAK 2322
             PP   NG   G N   F  G  + + C++GY LVG++   C   G W++ + P C    
Sbjct: 853  PPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPA-PHCKEVN 911

Query: 2323 CPEP---PLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCK 2377
            C  P     ++  L  +++     VVT  C++G++L+G    +C    QWN    VC+
Sbjct: 912  CSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCR 969



 Score = 80.9 bits (198), Expect = 2e-14
 Identities = 66/237 (27%), Positives = 98/237 (41%), Gaps = 44/237 (18%)

Query: 362 CREGYRASGQ------------------TCELVHCPALKPPENGYFIQNTCNN-HFNAAC 402
           C EGYR  G                    CE + CP+  P  NG  I N+  N  + +  
Sbjct: 242 CDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIV 301

Query: 403 GVRCHP------GFDLVGSSIILCLPN----GLWSGSESYCRVRT----CPHLRQPKHGH 448
              C P       F L+G S + C  +    G WSG    C + T    CPH +  +   
Sbjct: 302 TYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRM 361

Query: 449 ISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVI 508
           +S       Y  T + AC  G+ L+GS ++ C     W+   P C E+ C   Q P + I
Sbjct: 362 VSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVC-EKEC---QAPPN-I 416

Query: 509 ISPHNCGKQPAKF--GTICYVSCRQGFILSGVKEMLRCTTSGKWNVGV---QAAVCK 560
           ++     +   +F  GT    SC  G++L G +E ++CT+ G W   V   + A C+
Sbjct: 417 LNGQKEDRHMVRFDPGTSIKYSCNPGYVLVG-EESIQCTSEGVWTPPVPQCKVAACE 472



 Score = 73.2 bits (178), Expect = 4e-12
 Identities = 50/174 (28%), Positives = 72/174 (41%), Gaps = 15/174 (8%)

Query: 406 CHPGFDLVGSSIILC--LPNGLWSGSESYCRVRTCPHLRQPKHG-HISCSTREMLYKTTC 462
           C  G+ L G +  +C    NG+W      C+V  C       +G H        LY    
Sbjct: 685 CQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEV 744

Query: 463 LVACDEGYRLEGSDKLTC----QGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQP 518
              CD+G+ L G  KL C    +G+  W GP P+C+ R     + P   +   +   K  
Sbjct: 745 SYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL-RSPPVTRCPNPEVKHGYKLNKTH 803

Query: 519 AKF--GTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCP 570
           + +    I YV C  GFI++G   ++RC T   W  GV   + K      I CP
Sbjct: 804 SAYSHNDIVYVDCNPGFIMNG-SRVIRCHTDNTWVPGVPTCIKKAF----IGCP 852



 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 74/292 (25%), Positives = 108/292 (36%), Gaps = 60/292 (20%)

Query: 297 GTHTGHFECICEKGYYGKGLQYECTA-----------CPSGTYKPEGSPGGIS-SCIPCP 344
           G HTG    + E   YG  + YEC             C S + K  GS  G S  C+   
Sbjct: 728 GKHTG---MMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDS-KGHGSWSGPSPQCL--- 780

Query: 345 DENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGV 404
                SPP +  P   V + GY+ +       H                     N    V
Sbjct: 781 ----RSPPVTRCPNPEV-KHGYKLNKTHSAYSH---------------------NDIVYV 814

Query: 405 RCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTC----PHLRQPKHGHISCSTREMLYKT 460
            C+PGF + GS +I C  +  W      C  +      P  + P   H   +        
Sbjct: 815 DCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGM 874

Query: 461 TCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAK 520
           + L +CD+GY L G   L C     W  P P C E +CS+   P D  +     G +P K
Sbjct: 875 SILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSS---PAD--MDGIQKGLEPRK 929

Query: 521 ---FGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINC 569
              +G +  + C  G++L G  +  +C +  +WN  +  AVC+      + C
Sbjct: 930 MYQYGAVVTLECEDGYMLEGSPQS-QCQSDHQWNPPL--AVCRSRSLAPVLC 978



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 71/287 (24%), Positives = 102/287 (35%), Gaps = 61/287 (21%)

Query: 3299 CETPLEFLNGKADIENR--TTGPNVVYSCNRGYSLEGPSEAHCTE----NGTWSHPVPLC 3352
            C +P   LNG+    +     G  + YSC+  + L G     C      +GTW  P P C
Sbjct: 23   CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82

Query: 3353 ----KPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETW---- 3404
                K + CP P V     +     +    +V+  C+  F + G+  + C  +  W    
Sbjct: 83   EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTR 142

Query: 3405 TQTSAKCEKISCG--PPAHVENAIARGV-HYQYGDMITYSCYSGYMLEGFLRSVCLENGT 3461
              T      + C   P  H  +  +  V     G  +TYSC SGY+L G     CL +G 
Sbjct: 143  LPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK 202

Query: 3462 WTSPP------ICRAVCRFP-------------------CQNGGICQRPNACSCPEGWMG 3496
            W++ P       C+++ RFP                   C  G   Q P +  C     G
Sbjct: 203  WSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQG 262

Query: 3497 ------RLCEEPICIL--PCLNGGR-----------CVAPYQCDCPP 3524
                   +CEE  C    P LNG              +  Y CD  P
Sbjct: 263  VAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDP 309



 Score = 68.9 bits (167), Expect = 8e-11
 Identities = 77/258 (29%), Positives = 98/258 (37%), Gaps = 31/258 (12%)

Query: 297 GTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTS 356
           G HTG      E   YG  + Y C   P      E S  G  S I C   +     G+ S
Sbjct: 536 GAHTGSS---LEDFPYGTTVTYTCNPGPERGV--EFSLIG-ESTIRCTSNDQER--GTWS 587

Query: 357 PEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHF-NAACGVRCHPGFDLVGS 415
               +C+    A    C  VH        NGY I      +F N     +C+ GF L GS
Sbjct: 588 GPAPLCKLSLLAV--QCSHVHIA------NGYKISGKEAPYFYNDTVTFKCYSGFTLKGS 639

Query: 416 SIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGS 475
           S I C  +  W      C   TC H+RQ     +   +R  L  T    +C +GY+L G 
Sbjct: 640 SQIRCKADNTWDPEIPVCEKETCQHVRQSLQ-ELPAGSRVELVNT----SCQDGYQLTGH 694

Query: 476 DKLTCQG--NSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQ 531
               CQ   N  W    P C   HC     P  VI++  + G     F  G      C Q
Sbjct: 695 AYQMCQDAENGIWFKKIPLCKVIHCH----PPPVIVNGKHTGMMAENFLYGNEVSYECDQ 750

Query: 532 GFILSGVKEMLRCTTSGK 549
           GF L G K+ L+C +  K
Sbjct: 751 GFYLLGEKK-LQCRSDSK 767



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 49/172 (28%), Positives = 70/172 (40%), Gaps = 33/172 (19%)

Query: 406 CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPH-----LRQPKHGHISCSTREMLYKT 460
           C+PG+ LVG   I C   G+W+     C+V  C       L +P+H  +           
Sbjct: 439 CNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNS----- 493

Query: 461 TCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGK--QP 518
               +C EGY+L GS    CQG   W      C E  C     P  VI +  + G   + 
Sbjct: 494 ----SCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCP----PPPVIYNGAHTGSSLED 545

Query: 519 AKFGTICYVSCRQG------FILSGVKEMLRCTTS----GKWNVGVQAAVCK 560
             +GT    +C  G      F L G +  +RCT++    G W+    A +CK
Sbjct: 546 FPYGTTVTYTCNPGPERGVEFSLIG-ESTIRCTSNDQERGTWS--GPAPLCK 594



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 57/194 (29%), Positives = 80/194 (41%), Gaps = 27/194 (13%)

Query: 376 VHCPALKPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSGSES 431
           + CPAL    NG+   +T  N  + A G+     C  G+ LVG  II CL +G WS    
Sbjct: 152 LECPALPMIHNGH---HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPP 208

Query: 432 YCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEG--SDKLTCQGNSQWDGP 489
            C    C  L +  +G +      +    T    CDEGYRL+G  S +    G       
Sbjct: 209 TCEEARCKSLGRFPNGKVK-EPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK 267

Query: 490 EPRCVERHCSTFQMPKDVIISPHNCGKQPA--KFGTICYVSCRQ------GFILSGVKEM 541
            P C E  C +       I++  + G   A   +G+I   +C         FIL G +  
Sbjct: 268 MPVCEEIFCPS----PPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIG-EST 322

Query: 542 LRCTT----SGKWN 551
           LRCT     +G W+
Sbjct: 323 LRCTVDSQKTGTWS 336



 Score = 55.5 bits (132), Expect = 1e-06
 Identities = 45/195 (23%), Positives = 74/195 (37%), Gaps = 15/195 (7%)

Query: 378 CPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRT 437
           CP    P  GY I+ +       +    C   F + G+  + C  N +W  +     V  
Sbjct: 91  CPEPIVP-GGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSV 149

Query: 438 ----CPHLRQPKHG-HISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPR 492
               CP L    +G H S +   +    +   +C+ GY L G   + C  + +W    P 
Sbjct: 150 FPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPT 209

Query: 493 CVERHCSTFQMPKDVIISPHNCGKQP--AKFGTICYVSCRQGFILSGVKEMLRCTTSGKW 550
           C E  C      K +   P+   K+P   + G      C +G+ L G     RC  +G+ 
Sbjct: 210 CEEARC------KSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSS-RCVIAGQG 262

Query: 551 NVGVQAAVCKDVEAP 565
               +  VC+++  P
Sbjct: 263 VAWTKMPVCEEIFCP 277



 Score = 52.4 bits (124), Expect = 8e-06
 Identities = 44/161 (27%), Positives = 66/161 (40%), Gaps = 22/161 (13%)

Query: 406 CHPGFDLVGSSIILCLP----NGLWSGSESYC----RVRTCPHLRQPKHGHISCSTREML 457
           C   F L+G   +LC+     +G W      C    +  +CP    P    I  ST    
Sbjct: 51  CSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGST-PYR 109

Query: 458 YKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPE--PRCVERHCSTFQMPKDVIISPHNCG 515
           +  +   AC   + + G+  + CQ N+ W GP   P CV    S F +    +   HN  
Sbjct: 110 HGDSVTFACKTNFSMNGNKSVWCQANNMW-GPTRLPTCV----SVFPLECPALPMIHNGH 164

Query: 516 KQPAKFGTIC-----YVSCRQGFILSGVKEMLRCTTSGKWN 551
                 G+I        SC  G++L G K ++ C +SGKW+
Sbjct: 165 HTSENVGSIAPGLSVTYSCESGYLLVGEK-IINCLSSGKWS 204



 Score = 36.6 bits (83), Expect = 0.46
 Identities = 26/110 (23%), Positives = 45/110 (40%), Gaps = 7/110 (6%)

Query: 446 HGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC----QGNSQWDGPEPRCVERHCSTF 501
           +G IS  +  +   T    +C   +RL G   L C    + +  WD P P+C E      
Sbjct: 31  NGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC-EYFNKYS 89

Query: 502 QMPKDVIISPHNC-GKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKW 550
             P+ ++   +   G  P + G     +C+  F ++G K +  C  +  W
Sbjct: 90  SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVW-CQANNMW 138


>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  318 bits (814), Expect = 8e-86
 Identities = 336/1300 (25%), Positives = 538/1300 (41%), Gaps = 190/1300 (14%)

Query: 2258 MCVPLDCGKPPPIQN-----GFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNK 2312
            +CV  DC + PP +N     G    + +  G++  + C  GY  +G+    C+K G+W  
Sbjct: 15   ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-GEW-V 72

Query: 2313 KSNP--KCMPAKCPEPPLLENQLVLKELTT----EVGV-VTFSCKEGHVLQGPSVLKCLP 2365
              NP  KC    C  P   +       LT     E GV   ++C EG+ L G    +   
Sbjct: 73   ALNPLRKCQKRPCGHPG--DTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECD 130

Query: 2366 SQQWNDSFPVCKIVLCTPPPLISFGVPI-----PSSALHFGSTVKYSCVGGFFLRGNSTT 2420
            +  W +  P+C++V C P      G  +     P    HFG  V++ C  G+ + G+   
Sbjct: 131  TDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEM 190

Query: 2421 LCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTA--LYTCKPGFELVGNTTT 2478
             C  DG WS   P+CV + C  P+ I NG    Q + Y       Y C  G+E       
Sbjct: 191  HCSDDGFWSKEKPKCVEISCKSPDVI-NGSPISQKIIYKENERFQYKCNMGYEYSERGDA 249

Query: 2479 LCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHY--GQTVTYSCNRGF--RLEGPS 2534
            +C E+G W    P+C+   C  P  I NG +S   + +  G  +TY C  GF     G +
Sbjct: 250  VCTESG-W-RPLPSCEEKSCDNP-YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNT 306

Query: 2535 ALTCLETGDWDVDAPSCNAIHCDSPQPIENG-FVEGADYSY-----GAIIIYSCFPGFQV 2588
            A  C  TG W + AP C    CD P     G + E     Y     G    Y C   F+ 
Sbjct: 307  A-KCTSTG-W-IPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFET 363

Query: 2589 AGHAMQT---CEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPY 2645
               +      C + GWS ++P                 C +    + YF         PY
Sbjct: 364  PSGSYWDHIHCTQDGWSPAVP-----------------CLR----KCYF---------PY 393

Query: 2646 VTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYEL-LGNPVLICQEDGT 2704
            +               EN       H   F+ G  +   C+PGY L      + C E+G 
Sbjct: 394  L---------------ENGYNQ--NHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG- 435

Query: 2705 WNGSAPSCISIE-CDLPTAP-ENGFLRFTE--TSMGSAVQYSCKPGHILAGSDLRLCLEN 2760
            W+   P CI ++ C   +   ENGF+  ++   ++    +Y CK G++ A  +    +  
Sbjct: 436  WS-PTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITC 494

Query: 2761 RK--WSGASPRCEAISCKKPNPVMNGSIKGSNYTYL---STLYYECDPGYVLN-GTERRT 2814
             K  WS A P C   SC  P   MN   K +++T+     TL YEC  GY  N G+   +
Sbjct: 495  GKDGWS-AQPTC-IKSCDIP-VFMNARTK-NDFTWFKLNDTLDYECHDGYESNTGSTTGS 550

Query: 2815 CQDDKNWDEDEPICIPVDCSSPPVSAN--GQVRGDEYTFQKEIEYTCNEGFLLEGARSRV 2872
                 N   D PIC   +C  P +  +     + D+Y   + ++++C  GF + G  S  
Sbjct: 551  IVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQ 610

Query: 2873 CLANGSWSGATPDCVPV------RCATPPQLANGVTEGL---DYGFMKEVTFHCHEGYIL 2923
            C       G +PD +P+       C  PP+L NG  +     +YG  + V ++C+  +++
Sbjct: 611  CY----HFGLSPD-LPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLM 665

Query: 2924 HGAPKLTCQSDGNWDAEIPLC--KPVNCGPPEDLAHGFPNGFS--FIHGGHIQYQCFPGY 2979
             G  K+ C  DG W   +P+C  +   CG   +L HG+    S  + +G  +++ C   +
Sbjct: 666  KGPNKIQC-VDGEW-TTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESF 723

Query: 2980 KLHGNSSRRCLSNGSWSGSSPSCL------PCRCSTPVI-EYGTVNGTDFDCGKAARIQC 3032
             + G+ S  C+ +G W+   P C+       C+ S  +I E    N  +FD     R +C
Sbjct: 724  TMIGHRSITCI-HGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRC 781

Query: 3033 FKGFKLLGLSEITCEADGQWSSGFPHCEHTS---CGSLPMIPNAF-ISETSSWKE-NVIT 3087
             +G +  G     C  +G+W     +C       C   P IPN+  ++ T ++++   ++
Sbjct: 782  -RGKE--GWIHTVC-INGRWDPEV-NCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVS 836

Query: 3088 YSCRSGYVIQGSSDLICTEKGVWSQPYPVC-EPLSCGSPPSVANAV-----ATGEAHTYE 3141
              C+  Y+IQ   ++ C + G W Q  P+C E + C  PP + +       ++ E++ + 
Sbjct: 837  VLCQENYLIQEGEEITCKD-GRW-QSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHG 894

Query: 3142 SEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITH-ILVH-GDDFSV 3199
            +++   C  G+ +  + +T TC   G+W      C    C  P  I+H ++ H  D +  
Sbjct: 895  TKLSYTCEGGFRISEENET-TCYM-GKW-SSPPQCEGLPCKSPPEISHGVVAHMSDSYQY 951

Query: 3200 NRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSK--- 3256
              +V+  C EG+  +G  I+ C L   W  P    SC    C    S E+   +G K   
Sbjct: 952  GEEVTYKCFEGFGIDGPAIAKC-LGEKWSHP---PSCIKTDCLSLPSFENAIPMGEKKDV 1007

Query: 3257 YTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNG---KADIE 3313
            Y     + Y C   Y+++G     C  N +W+G    C++T C  P    N       + 
Sbjct: 1008 YKAGEQVTYTCATYYKMDGASNVTC-INSRWTGR-PTCRDTSCVNPPTVQNAYIVSRQMS 1065

Query: 3314 NRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPN--PCPVPFVIPENALLS- 3370
               +G  V Y C   Y + G  E  C  NG W+ P P CK +   C  P  I    + S 
Sbjct: 1066 KYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWTEP-PQCKDSTGKCGPPPPIDNGDITSF 1123

Query: 3371 -EKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVEN----- 3424
                +    +V  +C+  + L+G+  ITC   + W++   KC          +EN     
Sbjct: 1124 PLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQ-WSE-PPKCLHPCVISREIMENYNIAL 1181

Query: 3425 --AIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTW 3462
                 + ++ + G+ + + C  GY L    RS  L    W
Sbjct: 1182 RWTAKQKLYSRTGESVEFVCKRGYRLSS--RSHTLRTTCW 1219



 Score =  311 bits (797), Expect = 7e-84
 Identities = 332/1290 (25%), Positives = 520/1290 (40%), Gaps = 177/1290 (13%)

Query: 1685 CERISCGVPPPLEN-----GFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGV 1739
            C    C   PP  N     G  S   +  G+   Y+C  GY  LG+  M C   G W  +
Sbjct: 16   CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVAL 74

Query: 1740 SPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGH 1799
            +P                                       + C +   C  PG+   G 
Sbjct: 75   NPL--------------------------------------RKCQKR-PCGHPGDTPFGT 95

Query: 1800 ---SSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENG 1856
               + G ++  G +  ++C EGYQL+G       ++  W + IP C+ V C     PENG
Sbjct: 96   FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENG 155

Query: 1857 CIEELA------FTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPEN 1910
             I   A      + FG  V + CN GY + GD+E  C  +  WS   P C  + C SP+ 
Sbjct: 156  KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDV 215

Query: 1911 INNGKYILSGLTYLSTA--SYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPA 1968
            I NG  I   + Y       Y C+ GY         CT SG W R  P+C    C + P 
Sbjct: 216  I-NGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSC-DNPY 271

Query: 1969 IKDAVITGNNFTFR--NTVTYTCKEG-YTLAGLDTIECLADGKWSRSDQQCLAVSCDEPP 2025
            I +   +      R  + +TY C+ G Y     +T +C + G W  +  +C    CD P 
Sbjct: 272  IPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIPA-PRCTLKPCDYPD 329

Query: 2026 IVDHAS--PETAHRLFGDIAF-----YYCSDGYSLADNS---QLLCNAQGKWVPPEGQDM 2075
            I  H     E   R +  +A      YYC + +     S    + C   G W  P    +
Sbjct: 330  I-KHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-W-SPAVPCL 386

Query: 2076 PRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVL-NTSAKIECMRGGQWNP 2134
             +C   + E   + ++         KF  G  +   C  G+ L      + CM  G W+P
Sbjct: 387  RKCYFPYLENGYNQNHG-------RKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WSP 438

Query: 2135 SPMSIQCIPVRCGEPPS--IMNGYASGSNYSFG--AMVAYSCNKGFYIKGEKKS---TCE 2187
            +P   +CI V+     S  I NG+ S S Y++       Y C  G+     + S   TC 
Sbjct: 439  TP---RCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCG 495

Query: 2188 ATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKS-VGSPVFVCQ 2246
              G WS+  PTC   SC  P  +        T       + Y+C+ GY+S  GS      
Sbjct: 496  KDG-WSAQ-PTCIK-SCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIV 552

Query: 2247 ANRHWHSESPLMCVPLDCGKPPPIQNGFM---KGENFEVGSKVQFFCNEGYELVGDSSWT 2303
               +  S+ P+ C   +C + P I    +   K + ++VG  ++F C  G+ +VG +S  
Sbjct: 553  CGYNGWSDLPI-CYEREC-ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQ 610

Query: 2304 CQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVG---VVTFSCKEGHVLQGPSV 2360
            C   G        K     C  PP L N  V ++   E G   VV + C    +++GP+ 
Sbjct: 611  CYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNK 670

Query: 2361 LKCLPSQQWNDSFPVCKI--VLCTPPPLISFG-VPIPSSALHFGSTVKYSCVGGFFLRGN 2417
            ++C+   +W  + PVC +    C   P +  G   + S   ++G +V+++C   F + G+
Sbjct: 671  IQCVDG-EWT-TLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGH 728

Query: 2418 STTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLA------YLSTALYTCKPGFE 2471
             +  C   G W+  LP+CV ++  +  +  N II  + L       + S   Y C+ G E
Sbjct: 729  RSITC-IHGVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCR-GKE 785

Query: 2472 LVGNTTTLCGENGHWLGGKPTCKAIE---CLKPKEILNGKFSYTDLHY--GQTVTYSCNR 2526
              G   T+C  NG W   +  C   +   C  P +I N     T L+Y  G+ V+  C  
Sbjct: 786  --GWIHTVC-INGRW-DPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQE 841

Query: 2527 GFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGA-----DYSYGAIIIYS 2581
             + ++    +TC + G W         I C  P  IE+G +  +      Y++G  + Y+
Sbjct: 842  NYLIQEGEEITC-KDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYT 900

Query: 2582 CFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQ----- 2636
            C  GF+++     TC    WSS  P C  + C  PP I  G    + D   Y E+     
Sbjct: 901  CEGGFRISEENETTCYMGKWSSP-PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKC 959

Query: 2637 -EDDMMEVPYVT-------PHPPYHLGAVAKTWENTKESPATHSSNFLY--GTMVSYTCN 2686
             E   ++ P +         HPP  +     +  + + +        +Y  G  V+YTC 
Sbjct: 960  FEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCA 1019

Query: 2687 PGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFL---RFTETSMGSAVQYSC 2743
              Y++ G   + C  +  W G  P+C    C  P   +N ++   + ++   G  V+Y C
Sbjct: 1020 TYYKMDGASNVTC-INSRWTG-RPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQC 1077

Query: 2744 KPGHILAGSDLRLCLENRKWSGASPRCEAIS--CKKPNPVMNGSIKG---SNYTYLSTLY 2798
            +  + + G +  +CL N  W+   P+C+  +  C  P P+ NG I     S Y   S++ 
Sbjct: 1078 RSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVE 1135

Query: 2799 YECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQK----- 2853
            Y+C   Y L G +R TC++ + W E  P C+     S  +  N  +       QK     
Sbjct: 1136 YQCQNLYQLEGNKRITCRNGQ-WSE-PPKCLHPCVISREIMENYNIALRWTAKQKLYSRT 1193

Query: 2854 --EIEYTCNEGFLLEGARSRVCLANGSWSG 2881
               +E+ C  G+ L  +RS   L    W G
Sbjct: 1194 GESVEFVCKRGYRL-SSRSHT-LRTTCWDG 1221



 Score =  295 bits (754), Expect = 7e-79
 Identities = 322/1281 (25%), Positives = 490/1281 (38%), Gaps = 163/1281 (12%)

Query: 1798 GHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPY--CKAVSCGKPAIPEN 1855
            G  S + Y  G +  + C+ GY+ +G   + C   GEW  L P   C+   CG P     
Sbjct: 35   GSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPF 93

Query: 1856 GCIEEL---AFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENIN 1912
            G         F +G K  Y CN+GY L G+          W++  P+CE VKC       
Sbjct: 94   GTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPE 153

Query: 1913 NGKYILSGLT------YLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEP 1966
            NGK + S +       +     + C++GY ++G   + C+  G W +  P C  + C  P
Sbjct: 154  NGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSP 213

Query: 1967 PAIKDAVITGNNFTFRN-TVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEP- 2024
              I  + I+       N    Y C  GY  +      C   G W R    C   SCD P 
Sbjct: 214  DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSCDNPY 271

Query: 2025 -PIVDHASPETAHRLFGDIAFYYCSDG-YSLADNSQLLCNAQGKWVPPEGQDMPRCIAHF 2082
             P  D++     HR  GD   Y C +G Y     +   C + G W+P      PRC    
Sbjct: 272  IPNGDYSPLRIKHRT-GDEITYQCRNGFYPATRGNTAKCTSTG-WIP-----APRCTLKP 324

Query: 2083 CEKPPSVSYSIL--ESVSKAKF--AAGSVVSFKCMEGFVLNTSA---KIECMRGGQWNPS 2135
            C+  P + +  L  E++ +  F  A G   S+ C E F   + +    I C + G W+P 
Sbjct: 325  CDY-PDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSP- 381

Query: 2136 PMSIQCIPVRCGEPPSIMNGYAS--GSNYSFGAMVAYSCNKGFYI-KGEKKSTCEATGQW 2192
              ++ C+  R    P + NGY    G  +  G  +  +C+ G+ + K +   TC   G W
Sbjct: 382  --AVPCL--RKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-W 436

Query: 2193 SSPIPTCHPV-SCGEPP-KVENGFL-EHTTGRIFESEVRYQCNPGYKSV-GSPVFVCQAN 2248
             SP P C  V +C +    +ENGF+ E       + + +YQC  GY +  G         
Sbjct: 437  -SPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCG 495

Query: 2249 RHWHSESPLMCVPLDCGKPPPIQNGFMKGEN--FEVGSKVQFFCNEGYELVGDSSWTCQK 2306
            +   S  P      D    P   N   K +   F++   + + C++GYE    S+     
Sbjct: 496  KDGWSAQPTCIKSCDI---PVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIV 552

Query: 2307 SGKWNKKSNPKCMPAKCPEPPLLENQLV--LKELTTEVG-VVTFSCKEGHVLQGPSVLKC 2363
             G       P C   +C E P ++  LV   K+   +VG V+ FSCK G  + GP+ ++C
Sbjct: 553  CGYNGWSDLPICYEREC-ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQC 611

Query: 2364 LPSQQWNDSFPVCK--IVLCTPPPLISFGVPIPSSALHFG--STVKYSCVGGFFLRGNST 2419
                   D  P+CK  +  C PPP +  G     +   +G    V+Y C   F ++G + 
Sbjct: 612  YHFGLSPD-LPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNK 670

Query: 2420 TLCQPDGTWSSPLPECVPVE--CPQPEEIPNGIIDVQGLAYL--STALYTCKPGFELVGN 2475
              C  DG W++ LP C+  E  C    E+ +G   +    Y    +  + C   F ++G+
Sbjct: 671  IQC-VDGEWTT-LPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGH 728

Query: 2476 TTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSA 2535
             +  C  +G W    P C AI+ LK  +  N       L   +   ++ N  +R  G   
Sbjct: 729  RSITC-IHGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEG 786

Query: 2536 L--TCLETGDWD--VDAPSCNAIHCDSPQPIEN--GFVEGADYSYGAIIIYSCFPGFQVA 2589
               T    G WD  V+        C  P  I N        +Y  G  +   C   + + 
Sbjct: 787  WIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQ 846

Query: 2590 GHAMQTCEESGWSSSIPTCM-PIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTP 2648
                 TC++  W  SIP C+  I C  PP I+ G                          
Sbjct: 847  EGEEITCKDGRW-QSIPLCVEKIPCSQPPQIEHG-------------------------- 879

Query: 2649 HPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGS 2708
                           T  S  +   ++ +GT +SYTC  G+ +       C   G W+ S
Sbjct: 880  ---------------TINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM-GKWS-S 922

Query: 2709 APSCISIECDLPTAPENGFLRFTETS--MGSAVQYSCKPGHILAGSDLRLCLENRKWSGA 2766
             P C  + C  P    +G +     S   G  V Y C  G  + G  +  CL   KWS  
Sbjct: 923  PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCL-GEKWS-H 980

Query: 2767 SPRCEAISCKKPNPVMNGSIKGSN---YTYLSTLYYECDPGYVLNGTERRTCQDDKNWDE 2823
             P C    C       N    G     Y     + Y C   Y ++G    TC + + W  
Sbjct: 981  PPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSR-W-T 1038

Query: 2824 DEPICIPVDCSSPPVSANGQV---RGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWS 2880
              P C    C +PP   N  +   +  +Y   + + Y C   + + G    +CL NG+W+
Sbjct: 1039 GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWT 1097

Query: 2881 GATPDCVPV--RCATPPQLANGVTEGLD---YGFMKEVTFHCHEGYILHGAPKLTCQSDG 2935
               P C     +C  PP + NG         Y     V + C   Y L G  ++TC+ +G
Sbjct: 1098 -EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NG 1155

Query: 2936 NWDAEIPLCKPVNCGPPEDLAHGFPNGFSFI------------HGGHIQYQCFPGYKLHG 2983
             W       +P  C  P  ++      ++               G  +++ C  GY+L  
Sbjct: 1156 QWS------EPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRL-- 1207

Query: 2984 NSSRRCLSNGSWSG--SSPSC 3002
            +S    L    W G    P+C
Sbjct: 1208 SSRSHTLRTTCWDGKLEYPTC 1228



 Score =  293 bits (750), Expect = 2e-78
 Identities = 321/1228 (26%), Positives = 497/1228 (40%), Gaps = 169/1228 (13%)

Query: 2229 YQCNPGYKSVGSPVFVCQANRHWHSESPLM-CVPLDCGKP--PPIQNGFMKGEN-FEVGS 2284
            Y+C PGY+S+G+ + VC+    W + +PL  C    CG P   P     + G N FE G 
Sbjct: 50   YKCRPGYRSLGNVIMVCRKGE-WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGV 108

Query: 2285 KVQFFCNEGYELVGDSSWTCQKSGKWNKK----SNPKCMPAKCPEPPLLENQLVLKELTT 2340
            K  + CNEGY+L+G+ ++    +  W          KC+P   PE   + +  +  +   
Sbjct: 109  KAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREY 168

Query: 2341 EVG-VVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALH 2399
              G  V F C  G+ ++G   + C     W+   P C  + C  P +I+ G PI    ++
Sbjct: 169  HFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVIN-GSPISQKIIY 227

Query: 2400 F-GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAY 2458
                  +Y C  G+        +C   G W  PLP C    C  P  IPNG      + +
Sbjct: 228  KENERFQYKCNMGYEYSERGDAVCTESG-WR-PLPSCEEKSCDNPY-IPNGDYSPLRIKH 284

Query: 2459 LS--TALYTCKPGF-ELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFS----- 2510
             +     Y C+ GF       T  C   G W+   P C    C  P     G +      
Sbjct: 285  RTGDEITYQCRNGFYPATRGNTAKCTSTG-WIPA-PRCTLKPCDYPDIKHGGLYHENMRR 342

Query: 2511 -YTDLHYGQTVTYSCNRGFRLEGPSA-----LTCLETGDWDVDAPSCNAIHCDSPQPIEN 2564
             Y  +  G+  +Y C+  F  E PS      + C + G W    P      C  P  +EN
Sbjct: 343  PYFPVAVGKYYSYYCDEHF--ETPSGSYWDHIHCTQDG-WSPAVPCLRK--CYFPY-LEN 396

Query: 2565 GFVE--GADYSYGAIIIYSCFPGFQVA-GHAMQTCEESGWSSSIPTCMPIDCGLPPHIDF 2621
            G+ +  G  +  G  I  +C PG+ +       TC E+GWS + P C+ +       ID 
Sbjct: 397  GYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPT-PRCIRVKTCSKSSIDI 455

Query: 2622 --GDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSN----- 2674
              G  ++ +      E+     ++ YVT       G++    +     P    S      
Sbjct: 456  ENGFISESQYTYALKEKAKYQCKLGYVTADGETS-GSITCGKDGWSAQPTCIKSCDIPVF 514

Query: 2675 -----------FLYGTMVSYTCNPGYELLGNPV---LICQEDGTWNGSAPSCISIECDLP 2720
                       F     + Y C+ GYE         ++C  +G W+   P C   EC+LP
Sbjct: 515  MNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPICYERECELP 572

Query: 2721 T-----APENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASP-----RC 2770
                   P+    +  +  +G  +++SCKPG  + G +   C       G SP     + 
Sbjct: 573  KIDVHLVPDR---KKDQYKVGEVLKFSCKPGFTIVGPNSVQCYH----FGLSPDLPICKE 625

Query: 2771 EAISCKKPNPVMNGSIKGSN---YTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPI 2827
            +  SC  P  ++NG++K      Y +   + Y C+P +++ G  +  C D + W    P+
Sbjct: 626  QVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGE-WTT-LPV 683

Query: 2828 CIPVD--CSSPPVSANG--QVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGAT 2883
            CI  +  C   P   +G  Q+    Y +   +E+ C+E F + G RS  C+ +G W+   
Sbjct: 684  CIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI-HGVWT-QL 741

Query: 2884 PDCVPV----RCATPPQ--LANGVTEGLDYGFMKEVTFHCH--EGYILHGAPKLTCQSDG 2935
            P CV +    +C +     L   +    ++     + + C   EG+I       T   +G
Sbjct: 742  PQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIH------TVCING 795

Query: 2936 NWDAEI--PLCKPVNCGPPEDL--AHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLS 2991
             WD E+   + +   C PP  +  +H      ++  G  +   C   Y +       C  
Sbjct: 796  RWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITC-K 854

Query: 2992 NGSWSGSSPSC---LPCRCSTPVIEYGTVNGT-----DFDCGKAARIQCFKGFKLLGLSE 3043
            +G W  S P C   +PC    P IE+GT+N +      +  G      C  GF++   +E
Sbjct: 855  DGRWQ-SIPLCVEKIPCS-QPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENE 912

Query: 3044 ITCEADGQWSSGFPHCEHTSCGSLPMIPN---AFISETSSWKENVITYSCRSGYVIQGSS 3100
             TC   G+WSS  P CE   C S P I +   A +S++  + E V TY C  G+ I G +
Sbjct: 913  TTCYM-GKWSSP-PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEV-TYKCFEGFGIDGPA 969

Query: 3101 DLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGE---AHTYESEVKLRCLEGYTMDTD 3157
               C  +  WS P P C    C S PS  NA+  GE    +    +V   C   Y MD  
Sbjct: 970  IAKCLGEK-WSHP-PSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGA 1027

Query: 3158 TDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSV---NRQVSVSCAEGYTFE 3214
            ++  TC  + RW   R +C    C  P  + +  +     S      +V   C   Y   
Sbjct: 1028 SNV-TCI-NSRW-TGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMF 1084

Query: 3215 GVNISVCQLDGTW-EPPFSDESCSPVSCGKPESPEHGFVVG---SKYTFESTIIYQCEPG 3270
            G    +C L+G W EPP   +S     CG P   ++G +     S Y   S++ YQC+  
Sbjct: 1085 GDEEVMC-LNGNWTEPPQCKDSTG--KCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 1141

Query: 3271 YELEGNRERVCQENRQWSGGVAICKETRCETP-------LEFLN------GKADIENRTT 3317
            Y+LEGN+   C+ N QWS      +  +C  P       +E  N       K  + +R T
Sbjct: 1142 YQLEGNKRITCR-NGQWS------EPPKCLHPCVISREIMENYNIALRWTAKQKLYSR-T 1193

Query: 3318 GPNVVYSCNRGYSLEGPSEAHCTENGTW 3345
            G +V + C RGY L   S +H      W
Sbjct: 1194 GESVEFVCKRGYRLS--SRSHTLRTTCW 1219



 Score =  284 bits (727), Expect = 1e-75
 Identities = 302/1219 (24%), Positives = 480/1219 (39%), Gaps = 187/1219 (15%)

Query: 1651 GSKVNLFCDPGFQLVGNPVQY--CLNQGQWTQPLPHCERISCGVPPPLENG------FHS 1702
            G K    C+ G+QL+G  + Y  C   G WT  +P CE + C      ENG         
Sbjct: 107  GVKAVYTCNEGYQLLGE-INYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEP 164

Query: 1703 ADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVD----ECAVGSDCSEH 1758
              +++ G  V + CN+GY + GD  M C+D+G W+   P C+++     +   GS  S+ 
Sbjct: 165  DREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQK 224

Query: 1759 ASCL-NVDGSYICSCVPPYTGDG------------KNCAEPIKCKAPGNPENGHSSGEI- 1804
                 N    Y C+    Y+  G             +C E   C  P  P   +S   I 
Sbjct: 225  IIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEK-SCDNPYIPNGDYSPLRIK 283

Query: 1805 YTVGAEVTFSCQEG-YQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEE--- 1860
            +  G E+T+ C+ G Y         C  +G W    P C    C  P I   G   E   
Sbjct: 284  HRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIP-APRCTLKPCDYPDIKHGGLYHENMR 341

Query: 1861 ---LAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSH--------SPPVCEPVKCSSP- 1908
                    G   +Y C        D+     + S W H        SP V    KC  P 
Sbjct: 342  RPYFPVAVGKYYSYYC--------DEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPY 393

Query: 1909 ----ENINNGKYILSGLTYLSTASYSCDTGYSL-QGPSIIECTASGIWDRAPPACHLVFC 1963
                 N N+G+  + G     +   +C  GY+L +  + + C  +G W   P    +  C
Sbjct: 394  LENGYNQNHGRKFVQG----KSIDVACHPGYALPKAQTTVTCMENG-WSPTPRCIRVKTC 448

Query: 1964 GEPPA-IKDAVITGNNFTF--RNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVS 2020
             +    I++  I+ + +T+  +    Y CK GY  A  +T   +  GK   S Q     S
Sbjct: 449  SKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCIKS 508

Query: 2021 CDEPPIVD-HASPETAHRLFGDIAFYYCSDGYSLADNS---QLLCNAQGKWVPPEGQDMP 2076
            CD P  ++     +       D   Y C DGY     S    ++C   G W      D+P
Sbjct: 509  CDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-W-----SDLP 562

Query: 2077 RCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSP 2136
             C    CE  P +   ++    K ++  G V+ F C  GF +     ++C   G     P
Sbjct: 563  ICYERECEL-PKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLP 621

Query: 2137 MSIQCIPVRCGEPPSIMNGYA---SGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWS 2193
            +  + +   CG PP ++NG     +   Y    +V Y CN  F +KG  K  C   G+W+
Sbjct: 622  ICKEQVQ-SCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEWT 679

Query: 2194 S-PIPTCHPVSCGEPPKVENGFLEHTTGRIFESE-VRYQCNPGYKSVGSPVFVCQANRHW 2251
            + P+      +CG+ P++E+G+ + ++   +  + V + C+  +  +G     C  +  W
Sbjct: 680  TLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVW 738

Query: 2252 HSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSW--TCQKSGK 2309
             ++ P  CV +D  K     N  +  E+ +   +     N  Y   G   W  T   +G+
Sbjct: 739  -TQLP-QCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGR 796

Query: 2310 WNKKSNPKCMPAK---CPEPPLLENQLVLKELTTEVGV-----VTFSCKEGHVLQGPSVL 2361
            W+ + N  C  A+   CP PP + N      +TT +       V+  C+E +++Q    +
Sbjct: 797  WDPEVN--CSMAQIQLCPPPPQIPNS---HNMTTTLNYRDGEKVSVLCQENYLIQEGEEI 851

Query: 2362 KCLPSQQWNDSFPVC-KIVLCTPPPLISFGVPIPS----SALHFGSTVKYSCVGGFFLRG 2416
             C    +W  S P+C + + C+ PP I  G    S     +   G+ + Y+C GGF +  
Sbjct: 852  TC-KDGRW-QSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISE 909

Query: 2417 NSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIID--VQGLAYLSTALYTCKPGFELVG 2474
             + T C   G WSSP P+C  + C  P EI +G++        Y     Y C  GF + G
Sbjct: 910  ENETTCYM-GKWSSP-PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDG 967

Query: 2475 NTTTLCGENGHWLGGKPTCKAIECLKPKEILNG--KFSYTDLH-YGQTVTYSCNRGFRLE 2531
                 C   G      P+C   +CL      N        D++  G+ VTY+C   ++++
Sbjct: 968  PAIAKC--LGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMD 1025

Query: 2532 GPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFV---EGADYSYGAIIIYSCFPGFQV 2588
            G S +TC+ +  W    P+C    C +P  ++N ++   + + Y  G  + Y C   +++
Sbjct: 1026 GASNVTCINS-RW-TGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEM 1083

Query: 2589 AGHAMQTCEESGWSSSIPTCMPI--DCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYV 2646
             G     C    W+   P C      CG PP ID GD T                     
Sbjct: 1084 FGDEEVMCLNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSF------------------- 1123

Query: 2647 TPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWN 2706
                P  + A A +                    V Y C   Y+L GN  + C+ +G W+
Sbjct: 1124 ----PLSVYAPASS--------------------VEYQCQNLYQLEGNKRITCR-NGQWS 1158

Query: 2707 GSAPSCISIECDLPTAPENGF---LRFTE-----TSMGSAVQYSCKPGHILAGSDLRLCL 2758
               P C+   C +       +   LR+T      +  G +V++ CK G+ L  S     L
Sbjct: 1159 -EPPKCLH-PCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRL--SSRSHTL 1214

Query: 2759 ENRKWSGASPRCEAISCKK 2777
                W G   + E  +C K
Sbjct: 1215 RTTCWDG---KLEYPTCAK 1230



 Score =  283 bits (725), Expect = 2e-75
 Identities = 294/1166 (25%), Positives = 467/1166 (40%), Gaps = 137/1166 (11%)

Query: 2401 GSTVKYSCVGGFFLRGNSTTLCQPDGTWSS--PLPECVPVECPQPEEIPNGIIDVQG--- 2455
            G+   Y C  G+   GN   +C+  G W +  PL +C    C  P + P G   + G   
Sbjct: 45   GTQAIYKCRPGYRSLGNVIMVCRK-GEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103

Query: 2456 LAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYT--- 2512
              Y   A+YTC  G++L+G       +   W    P C+ ++CL      NGK   +   
Sbjct: 104  FEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAME 163

Query: 2513 ---DLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFV-E 2568
               + H+GQ V + CN G+++EG   + C + G W  + P C  I C SP  I    + +
Sbjct: 164  PDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQ 223

Query: 2569 GADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLK 2628
               Y       Y C  G++ +      C ESGW   +P+C    C   P+I  GD + L+
Sbjct: 224  KIIYKENERFQYKCNMGYEYSERGDAVCTESGWRP-LPSCEEKSCD-NPYIPNGDYSPLR 281

Query: 2629 DDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKT-----------------WENTKESPATH 2671
                   +  D +         P   G  AK                  + + K     H
Sbjct: 282  IKH----RTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYH 337

Query: 2672 SSN------FLYGTMVSYTCNPGYELLGNPV---LICQEDGTWNGSAPSCISIECDLPTA 2722
             +          G   SY C+  +E         + C +DG W+ + P C+  +C  P  
Sbjct: 338  ENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLR-KCYFPYL 394

Query: 2723 PENGFLRF--TETSMGSAVQYSCKPGHILAGSDLRL-CLENRKWSGASPRCEAI-SCKKP 2778
             ENG+ +    +   G ++  +C PG+ L  +   + C+EN  WS  +PRC  + +C K 
Sbjct: 395  -ENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WS-PTPRCIRVKTCSKS 451

Query: 2779 N-PVMNGSIKGSNYTYL--STLYYECDPGYVLNGTERR---TCQDDKNWDEDEPICIPVD 2832
            +  + NG I  S YTY       Y+C  GYV    E     TC  D  W   +P CI   
Sbjct: 452  SIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKD-GWSA-QPTCIK-S 508

Query: 2833 CSSPPVSANGQVRGDEYTFQKE--IEYTCNEGFLLEGAR---SRVCLANGSWSGATPDCV 2887
            C  P V  N + + D   F+    ++Y C++G+         S VC  NG WS   P C 
Sbjct: 509  CDIP-VFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WSDL-PICY 565

Query: 2888 PVRCATPPQLANGVTEGL--DYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCK 2945
               C  P    + V +     Y   + + F C  G+ + G   + C   G    ++P+CK
Sbjct: 566  ERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG-LSPDLPICK 624

Query: 2946 PV--NCGPPEDLAHGFPNGFSFIHGGH---IQYQCFPGYKLHGNSSRRCLSNGSWSGSSP 3000
                +CGPP +L +G     +    GH   ++Y C P + + G +  +C+ +G W+ + P
Sbjct: 625  EQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWT-TLP 682

Query: 3001 SCL--PCRCST-PVIEYG--TVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSG 3055
             C+     C   P +E+G   ++   +  G +    C + F ++G   ITC   G W+  
Sbjct: 683  VCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWTQ- 740

Query: 3056 FPHC------EHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGV 3109
             P C      +     +L ++     ++      + I Y CR     +G    +C   G 
Sbjct: 741  LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGK---EGWIHTVCIN-GR 796

Query: 3110 WSQPYPVCEPLS---CGSPPSVANAVATGEAHTYES--EVKLRCLEGYTMDTDTDTFTCQ 3164
            W  P   C       C  PP + N+        Y    +V + C E Y +  + +  TC 
Sbjct: 797  WD-PEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQ-EGEEITC- 853

Query: 3165 KDGRWFPERISCSPKKCPLPENITHILVHG-----DDFSVNRQVSVSCAEGYTFEGVNIS 3219
            KDGRW    +      C  P  I H  ++      + ++   ++S +C  G+     N +
Sbjct: 854  KDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENET 913

Query: 3220 VCQLDGTWEPPFSDESCSPVSCGKPESPEHGFV--VGSKYTFESTIIYQCEPGYELEGNR 3277
             C + G W  P     C  + C  P    HG V  +   Y +   + Y+C  G+ ++G  
Sbjct: 914  TCYM-GKWSSP---PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPA 969

Query: 3278 ERVCQENRQWSGGVAICKETRCETPLEFLNG-----KADIENRTTGPNVVYSCNRGYSLE 3332
               C    +WS   + C +T C +   F N      K D+     G  V Y+C   Y ++
Sbjct: 970  IAKCL-GEKWSHPPS-CIKTDCLSLPSFENAIPMGEKKDVYK--AGEQVTYTCATYYKMD 1025

Query: 3333 GPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEK--EFYVDQNVSIKCREGFLL 3390
            G S   C  N  W+   P C+   C  P  +    ++S +  ++   + V  +CR  + +
Sbjct: 1026 GASNVTCI-NSRWTGR-PTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEM 1083

Query: 3391 QGHGIITCNPDETWTQT-SAKCEKISCGPPAHVENAIARGVH---YQYGDMITYSCYSGY 3446
             G   + C  +  WT+    K     CGPP  ++N          Y     + Y C + Y
Sbjct: 1084 FGDEEVMCL-NGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY 1142

Query: 3447 MLEGFLRSVCLENGTWTSPPICRAVC 3472
             LEG  R  C  NG W+ PP C   C
Sbjct: 1143 QLEGNKRITC-RNGQWSEPPKCLHPC 1167



 Score =  271 bits (694), Expect = 6e-72
 Identities = 322/1277 (25%), Positives = 497/1277 (38%), Gaps = 207/1277 (16%)

Query: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWT--QPLPHCERISCGVPPPLENGFHS---ADD 1705
            G++    C PG++ +GN +  C  +G+W    PL  C++  CG P     G  +    + 
Sbjct: 45   GTQAIYKCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103

Query: 1706 FYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDEC---AVGSDCSEHASCL 1762
            F  G    Y CN GY LLG+      D   W    P C +V +C       +    +S +
Sbjct: 104  FEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPIC-EVVKCLPVTAPENGKIVSSAM 162

Query: 1763 NVDGSY--------ICSCVPPYTGDGK-NCAE------------PIKCKAP----GNPEN 1797
              D  Y        +C+      GD + +C++             I CK+P    G+P  
Sbjct: 163  EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSP-- 220

Query: 1798 GHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGC 1857
              S   IY       + C  GY+        C ESG W  L P C+  SC  P IP NG 
Sbjct: 221  -ISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPL-PSCEEKSCDNPYIP-NGD 276

Query: 1858 IEELAFTF--GSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGK 1915
               L      G ++TY+C  G+  A    ++   ++ W  +P  C    C  P+  + G 
Sbjct: 277  YSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPR-CTLKPCDYPDIKHGGL 335

Query: 1916 Y----------ILSGLTYLSTASYSCDTGYSLQGPSI---IECTASGIWDRAPPACHLVF 1962
            Y          +  G  Y    SY CD  +     S    I CT  G W  A P     +
Sbjct: 336  YHENMRRPYFPVAVGKYY----SYYCDEHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCY 390

Query: 1963 CGEPPAIKDAVIT--GNNFTFRNTVTYTCKEGYTL-AGLDTIECLADGKWSRSDQQCLAV 2019
                P +++      G  F    ++   C  GY L     T+ C+ +G WS + +     
Sbjct: 391  F---PYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPTPRCIRVK 446

Query: 2020 SCDEPPI-VDHASPETAHRLFG--DIAFYYCSDGYSLAD---NSQLLCNAQGKWVPPEGQ 2073
            +C +  I +++     +   +   + A Y C  GY  AD   +  + C   G W      
Sbjct: 447  TCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDG-W-----S 500

Query: 2074 DMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLN---TSAKIECMRGG 2130
              P CI   C+ P  V  +         F     + ++C +G+  N   T+  I C   G
Sbjct: 501  AQPTCIKS-CDIP--VFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG 557

Query: 2131 QWNPSPMSIQCIPVRCGEPPSI---MNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCE 2187
             W+  P+   C    C E P I   +        Y  G ++ +SC  GF I G     C 
Sbjct: 558  -WSDLPI---CYEREC-ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCY 612

Query: 2188 ATGQWSSPIPTC--HPVSCGEPPKVENGFLEHTTGRIF--ESEVRYQCNPGYKSVGSPVF 2243
              G  S  +P C     SCG PP++ NG ++  T   +     V Y CNP +   G    
Sbjct: 613  HFG-LSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKI 671

Query: 2244 VCQANRHWHSESPLMCVPLDCGKPPPIQNGF--MKGENFEVGSKVQFFCNEGYELVGDSS 2301
             C  +  W +    +     CG  P +++G+  +    +  G  V+F C+E + ++G  S
Sbjct: 672  QC-VDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRS 730

Query: 2302 WTCQKSGKWNKKSNPKCMP----AKCPEPPL--LENQLVLKELTTEVGVVTFSC--KEGH 2353
             TC   G W +   P+C+      KC    L  LE  L  K+       + + C  KEG 
Sbjct: 731  ITC-IHGVWTQL--PQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGW 787

Query: 2354 VLQGPSVLKCLPSQQWND--SFPVCKIVLCTPPPLISFGVPIPSSALHF--GSTVKYSCV 2409
            +        C+ + +W+   +  + +I LC PPP I     + ++ L++  G  V   C 
Sbjct: 788  I-----HTVCI-NGRWDPEVNCSMAQIQLCPPPPQIPNSHNM-TTTLNYRDGEKVSVLCQ 840

Query: 2410 GGFFLRGNSTTLCQPDGTWSSPLPECV-PVECPQPEEIPNGIID-----VQGLAYLSTAL 2463
              + ++      C+ DG W S +P CV  + C QP +I +G I+      +  A+ +   
Sbjct: 841  ENYLIQEGEEITCK-DGRWQS-IPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLS 898

Query: 2464 YTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSY--TDLHYGQTVT 2521
            YTC+ GF +     T C   G W    P C+ + C  P EI +G  ++      YG+ VT
Sbjct: 899  YTCEGGFRISEENETTC-YMGKW-SSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVT 956

Query: 2522 YSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGAD---YSYGAII 2578
            Y C  GF ++GP+   CL  G+     PSC    C S    EN    G     Y  G  +
Sbjct: 957  YKCFEGFGIDGPAIAKCL--GEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQV 1014

Query: 2579 IYSCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQED 2638
             Y+C   +++ G +  TC  S W+   PTC    C  PP +                   
Sbjct: 1015 TYTCATYYKMDGASNVTCINSRWTGR-PTCRDTSCVNPPTV------------------- 1054

Query: 2639 DMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLI 2698
               +  Y+                      +   S +  G  V Y C   YE+ G+  ++
Sbjct: 1055 ---QNAYIV---------------------SRQMSKYPSGERVRYQCRSPYEMFGDEEVM 1090

Query: 2699 CQEDGTWNGSAPSC--ISIECDLPTAPENGFLRFTETSM---GSAVQYSCKPGHILAGSD 2753
            C  +G W    P C   + +C  P   +NG +     S+    S+V+Y C+  + L G+ 
Sbjct: 1091 CL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNK 1148

Query: 2754 LRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLY--------YECDPGY 2805
             R+   N +WS   P+C    C     +M        +T    LY        + C  GY
Sbjct: 1149 -RITCRNGQWS-EPPKC-LHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGY 1205

Query: 2806 VLNG---TERRTCQDDK 2819
             L+    T R TC D K
Sbjct: 1206 RLSSRSHTLRTTCWDGK 1222



 Score =  264 bits (674), Expect = 1e-69
 Identities = 296/1176 (25%), Positives = 451/1176 (38%), Gaps = 163/1176 (13%)

Query: 2435 CVPVECPQ-----PEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGG 2489
            CV  +C +       EI  G    Q     + A+Y C+PG+  +GN   +C   G W+  
Sbjct: 16   CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74

Query: 2490 KPT--CKAIECLKPKEILNGKFSYTD---LHYGQTVTYSCNRGFRLEGPSALTCLETGDW 2544
             P   C+   C  P +   G F+ T      YG    Y+CN G++L G       +T  W
Sbjct: 75   NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGW 134

Query: 2545 DVDAPSCNAIHCDSPQPIENGFVEGA------DYSYGAIIIYSCFPGFQVAGHAMQTCEE 2598
              D P C  + C      ENG +  +      +Y +G  + + C  G+++ G     C +
Sbjct: 135  TNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSD 194

Query: 2599 SG-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAV 2657
             G WS   P C+ I C  P  I+                                     
Sbjct: 195  DGFWSKEKPKCVEISCKSPDVIN------------------------------------- 217

Query: 2658 AKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIEC 2717
                     SP +    +       Y CN GYE       +C E G W    PSC    C
Sbjct: 218  --------GSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WR-PLPSCEEKSC 267

Query: 2718 DLPTAPENGF--LRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISC 2775
            D P  P   +  LR    + G  + Y C+ G   A         +  W  A PRC    C
Sbjct: 268  DNPYIPNGDYSPLRIKHRT-GDEITYQCRNGFYPATRGNTAKCTSTGWIPA-PRCTLKPC 325

Query: 2776 KKPNPVMNGSIKGSN-------------YTYLSTLYYECDPGYVLNGTERRTCQDDKNWD 2822
              P+ + +G +   N             Y+Y    ++E   G   +      C  D  W 
Sbjct: 326  DYPD-IKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIH---CTQD-GWS 380

Query: 2823 EDEPICIPVDCSSPPVSANG--QVRGDEYTFQKEIEYTCNEGFLLEGARSRV-CLANGSW 2879
               P C+   C  P +  NG  Q  G ++   K I+  C+ G+ L  A++ V C+ NG W
Sbjct: 381  PAVP-CLR-KCYFPYLE-NGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-W 436

Query: 2880 SGATPDCVPVRCATPPQL--ANG-VTEG-LDYGFMKEVTFHCHEGYIL---HGAPKLTCQ 2932
            S  TP C+ V+  +   +   NG ++E    Y   ++  + C  GY+      +  +TC 
Sbjct: 437  S-PTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCG 495

Query: 2933 SDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIH-GGHIQYQCFPGYKLHGNSSRRCLS 2991
             DG W A+ P C   +C  P  +     N F++      + Y+C  GY+ +  S+   + 
Sbjct: 496  KDG-WSAQ-PTCIK-SCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIV 552

Query: 2992 NG--SWSGSSPSCLPCRCSTPVIEYGTV---NGTDFDCGKAARIQCFKGFKLLGLSEITC 3046
             G   WS   P C    C  P I+   V       +  G+  +  C  GF ++G + + C
Sbjct: 553  CGYNGWS-DLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQC 611

Query: 3047 EADGQWSSGFPHCEHT--SCGSLPMIPNAFISETSSWK---ENVITYSCRSGYVIQGSSD 3101
               G  S   P C+    SCG  P + N  + E +  +     V+ Y C   ++++G + 
Sbjct: 612  YHFGL-SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNK 670

Query: 3102 LICTEKGVWSQPYPVC--EPLSCGSPPSVANAVA--TGEAHTYESEVKLRCLEGYTMDTD 3157
            + C + G W+   PVC  E  +CG  P + +  A  +   + Y   V+  C E +TM   
Sbjct: 671  IQCVD-GEWTT-LPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTM-IG 727

Query: 3158 TDTFTCQKDGRW--FPERISCSP-KKCPLPENIT--HILVHGDDFSVNRQVSVSCAEGYT 3212
              + TC   G W   P+ ++    KKC     I     L +  +F  N  +   C     
Sbjct: 728  HRSITCIH-GVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGK-- 784

Query: 3213 FEGVNISVCQLDGTWEPPFSDESCSPVSCGKPES--PEHGFVVGSKYTFESTIIYQCEPG 3270
             EG   +VC ++G W+P  +        C  P      H       Y     +   C+  
Sbjct: 785  -EGWIHTVC-INGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQEN 842

Query: 3271 YELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNG-----KADIENRTTGPNVVYSC 3325
            Y ++   E  C++ R W       ++  C  P +  +G     ++  E+   G  + Y+C
Sbjct: 843  YLIQEGEEITCKDGR-WQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTC 901

Query: 3326 NRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFY-VDQNVSIKC 3384
              G+ +   +E  C   G WS P P C+  PC  P  I    +    + Y   + V+ KC
Sbjct: 902  EGGFRISEENETTCYM-GKWSSP-PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKC 959

Query: 3385 REGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVH---YQYGDMITYS 3441
             EGF + G  I  C   E W+   + C K  C      ENAI  G     Y+ G+ +TY+
Sbjct: 960  FEGFGIDGPAIAKCL-GEKWSHPPS-CIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYT 1017

Query: 3442 CYSGYMLEGFLRSVCLENGTWTSPPICR-AVCRFP--CQNGGICQRPNACSCPEGWMGRL 3498
            C + Y ++G     C+ N  WT  P CR   C  P   QN  I  R      P G   R 
Sbjct: 1018 CATYYKMDGASNVTCI-NSRWTGRPTCRDTSCVNPPTVQNAYIVSR-QMSKYPSGERVRY 1075

Query: 3499 -CEEPICI-----LPCLNGGRCVAPYQCDCPPGWTG 3528
             C  P  +     + CLN G    P QC    G  G
Sbjct: 1076 QCRSPYEMFGDEEVMCLN-GNWTEPPQCKDSTGKCG 1110



 Score =  182 bits (461), Expect = 7e-45
 Identities = 180/700 (25%), Positives = 269/700 (38%), Gaps = 126/700 (18%)

Query: 1646 EDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCER--ISCGVPPPLENG---F 1700
            +  K G  +   C PGF +VG     C + G  +  LP C+    SCG PP L NG    
Sbjct: 585  DQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG-LSPDLPICKEQVQSCGPPPELLNGNVKE 643

Query: 1701 HSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHAS 1760
             + +++     V Y CN  + + G +++ C D G W  + P C+            E ++
Sbjct: 644  KTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVD-GEWTTL-PVCI-----------VEEST 690

Query: 1761 CLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEI----YTVGAEVTFSCQ 1816
            C ++                              PE  H   ++    Y  G  V F+C 
Sbjct: 691  CGDI------------------------------PELEHGWAQLSSPPYYYGDSVEFNCS 720

Query: 1817 EGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEE------LAFTFGSKVT 1870
            E + ++G   ITC+  G W  L P C A+   K     N  I E        F   S + 
Sbjct: 721  ESFTMIGHRSITCIH-GVWTQL-PQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIR 778

Query: 1871 YRCNKGYTLAGDKESSCLANSSWSHSPPV-CEPVK---CSSPENINNGKYILSGLTYL-- 1924
            YRC       G   + C+ N  W   P V C   +   C  P  I N   + + L Y   
Sbjct: 779  YRCR---GKEGWIHTVCI-NGRW--DPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDG 832

Query: 1925 STASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGN-----NF 1979
               S  C   Y +Q    I C   G W   P     + C +PP I+   I  +     ++
Sbjct: 833  EKVSVLCQENYLIQEGEEITC-KDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESY 891

Query: 1980 TFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHR-- 2037
                 ++YTC+ G+ ++  +   C   GKWS S  QC  + C  PP + H     AH   
Sbjct: 892  AHGTKLSYTCEGGFRISEENETTCYM-GKWS-SPPQCEGLPCKSPPEISHG--VVAHMSD 947

Query: 2038 --LFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILE 2095
               +G+   Y C +G+ +   +   C  + KW  P     P CI   C   PS   +I  
Sbjct: 948  SYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWSHP-----PSCIKTDCLSLPSFENAIPM 1001

Query: 2096 SVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNG 2155
               K  + AG  V++ C   + ++ ++ + C+   +W   P    C    C  PP++ N 
Sbjct: 1002 GEKKDVYKAGEQVTYTCATYYKMDGASNVTCI-NSRWTGRP---TCRDTSCVNPPTVQNA 1057

Query: 2156 YASG---SNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVS--CGEPPKV 2210
            Y      S Y  G  V Y C   + + G+++  C   G W+ P P C   +  CG PP +
Sbjct: 1058 YIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGNWTEP-PQCKDSTGKCGPPPPI 1115

Query: 2211 ENGFLEHTTGRIF--ESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPP 2268
            +NG +      ++   S V YQC   Y+  G+    C+ N  W SE P       C  P 
Sbjct: 1116 DNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQW-SEPP------KCLHPC 1167

Query: 2269 PIQNGFMKGENF------------EVGSKVQFFCNEGYEL 2296
             I    M+  N               G  V+F C  GY L
Sbjct: 1168 VISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRL 1207



 Score =  134 bits (336), Expect = 2e-30
 Identities = 107/399 (26%), Positives = 165/399 (41%), Gaps = 82/399 (20%)

Query: 1624 KSIFCSDCPRLG-GSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPL 1682
            + I CS  P++  G++   R++ E    G+K++  C+ GF++       C   G+W+ P 
Sbjct: 866  EKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCY-MGKWSSP- 923

Query: 1683 PHCERISCGVPPPLENGF--HSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVS 1740
            P CE + C  PP + +G   H +D +  G  VTY+C  G+ + G +   C          
Sbjct: 924  PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC---------- 973

Query: 1741 PSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHS 1800
                      +G   S   SC+  D    C  +P +                   EN   
Sbjct: 974  ----------LGEKWSHPPSCIKTD----CLSLPSF-------------------ENAIP 1000

Query: 1801 SGE---IYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGC 1857
             GE   +Y  G +VT++C   Y++ G + +TC+ S  W    P C+  SC  P   +N  
Sbjct: 1001 MGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINS-RWTGR-PTCRDTSCVNPPTVQNAY 1058

Query: 1858 I---EELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPV--KCSSPENIN 1912
            I   +   +  G +V Y+C   Y + GD+E  CL N +W+  PP C+    KC  P  I+
Sbjct: 1059 IVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPID 1116

Query: 1913 NG---KYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAI 1969
            NG    + LS     S+  Y C   Y L+G   I C  +G W   P   H      P  I
Sbjct: 1117 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEPPKCLH------PCVI 1169

Query: 1970 KDAVITGNNFTFR------------NTVTYTCKEGYTLA 1996
               ++   N   R             +V + CK GY L+
Sbjct: 1170 SREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLS 1208



 Score = 55.5 bits (132), Expect = 1e-06
 Identities = 52/209 (24%), Positives = 79/209 (37%), Gaps = 27/209 (12%)

Query: 362 CREGYRASGQT---CELVHCPALKP-----------PENGYFIQNTCNNHFNAACGVR-- 405
           CR GYR+ G     C      AL P           P +  F   T         GV+  
Sbjct: 52  CRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAV 111

Query: 406 --CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCST----REMLYK 459
             C+ G+ L+G           W+     C V  C  +  P++G I  S     RE  + 
Sbjct: 112 YTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFG 171

Query: 460 TTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPA 519
                 C+ GY++EG +++ C  +  W   +P+CVE  C +  +     IS     K+  
Sbjct: 172 QAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENE 231

Query: 520 KFGTICYVSCRQGFILSGVKEMLRCTTSG 548
           +F       C  G+  S   + + CT SG
Sbjct: 232 RF----QYKCNMGYEYSERGDAV-CTESG 255



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 70/288 (24%), Positives = 108/288 (37%), Gaps = 29/288 (10%)

Query: 278  SYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGI 337
            +YL  EG++      +CK G       C+ EK    +  Q E     S     E    G 
Sbjct: 842  NYLIQEGEEI-----TCKDGRWQSIPLCV-EKIPCSQPPQIEHGTINSSRSSQESYAHGT 895

Query: 338  SSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPE--NGYFIQNTCN 395
                 C      S    T+     C  G  +S   CE + C +  PPE  +G     + +
Sbjct: 896  KLSYTCEGGFRISEENETT-----CYMGKWSSPPQCEGLPCKS--PPEISHGVVAHMSDS 948

Query: 396  NHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTRE 455
              +      +C  GF + G +I  CL    WS   S C    C  L   ++  I    ++
Sbjct: 949  YQYGEEVTYKCFEGFGIDGPAIAKCL-GEKWSHPPS-CIKTDCLSLPSFENA-IPMGEKK 1005

Query: 456  MLYKT--TCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHN 513
             +YK        C   Y+++G+  +TC  NS+W G  P C +  C      ++  I    
Sbjct: 1006 DVYKAGEQVTYTCATYYKMDGASNVTCI-NSRWTG-RPTCRDTSCVNPPTVQNAYIVSRQ 1063

Query: 514  CGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKD 561
              K P+  G      CR  + + G +E++    +G W    Q   CKD
Sbjct: 1064 MSKYPS--GERVRYQCRSPYEMFGDEEVM--CLNGNWTEPPQ---CKD 1104



 Score = 48.1 bits (113), Expect = 2e-04
 Identities = 41/182 (22%), Positives = 70/182 (38%), Gaps = 6/182 (3%)

Query: 405 RCHPGFDLVGSSIILCLPNGLWSGSESY--CRVRTCPHLRQPKHGHISCSTREML-YKTT 461
           +C PG+  +G+ I++C   G W        C+ R C H      G  + +   +  Y   
Sbjct: 51  KCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVK 109

Query: 462 CLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKD-VIISPHNCGKQPAK 520
            +  C+EGY+L G           W    P C    C     P++  I+S      +   
Sbjct: 110 AVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYH 169

Query: 521 FGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQ 580
           FG      C  G+ + G +EM  C+  G W+      V    ++P +     I  K + +
Sbjct: 170 FGQAVRFVCNSGYKIEGDEEM-HCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYK 228

Query: 581 QD 582
           ++
Sbjct: 229 EN 230



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 43/156 (27%), Positives = 64/156 (41%), Gaps = 11/156 (7%)

Query: 345 DENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGV 404
           DE+  +P GS        ++G+  +       + P L   ENGY   +        +  V
Sbjct: 358 DEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYL---ENGYNQNHGRKFVQGKSIDV 414

Query: 405 RCHPGFDL-VGSSIILCLPNGLWSGSESYCRVRTCPHLR-QPKHGHISCSTREMLYKTTC 462
            CHPG+ L    + + C+ NG WS +    RV+TC       ++G IS S      K   
Sbjct: 415 ACHPGYALPKAQTTVTCMENG-WSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKA 473

Query: 463 LVACDEGYRL---EGSDKLTCQGNSQWDGPEPRCVE 495
              C  GY     E S  +TC G   W   +P C++
Sbjct: 474 KYQCKLGYVTADGETSGSITC-GKDGWSA-QPTCIK 507



 Score = 43.9 bits (102), Expect = 0.003
 Identities = 43/194 (22%), Positives = 82/194 (42%), Gaps = 13/194 (6%)

Query: 372  TCELVHCPALKPPENGYFIQNTCNNHFNAA-CGVRCHPGFDLVGSSIILCLPNGLWSGSE 430
            TC    C      +N Y +    + + +      +C   +++ G   ++CL NG W+   
Sbjct: 1042 TCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWT-EP 1099

Query: 431  SYCRVRT--CPHLRQPKHGHISCSTREMLYKTTCL-VACDEGYRLEGSDKLTCQGNSQWD 487
              C+  T  C       +G I+     +    + +   C   Y+LEG+ ++TC+ N QW 
Sbjct: 1100 PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS 1158

Query: 488  GPEPRCVERHCSTFQMPKDVIISPHNCGKQP--AKFGTICYVSCRQGFILSGVKEMLRCT 545
             P P+C+     + ++ ++  I+     KQ   ++ G      C++G+ LS     LR T
Sbjct: 1159 EP-PKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTT 1217

Query: 546  TSGKWNVGVQAAVC 559
                W+  ++   C
Sbjct: 1218 C---WDGKLEYPTC 1228



 Score = 39.3 bits (90), Expect = 0.071
 Identities = 36/149 (24%), Positives = 60/149 (40%), Gaps = 7/149 (4%)

Query: 423 NGLWSGSE--SYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC 480
           NG W      S  +++ CP   Q  + H   +T          V C E Y ++  +++TC
Sbjct: 794 NGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITC 853

Query: 481 QGNSQWDGPEPRCVER-HCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVK 539
           + + +W    P CVE+  CS     +   I+     ++    GT    +C  GF +S  +
Sbjct: 854 K-DGRWQS-IPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRIS--E 909

Query: 540 EMLRCTTSGKWNVGVQAAVCKDVEAPQIN 568
           E       GKW+   Q         P+I+
Sbjct: 910 ENETTCYMGKWSSPPQCEGLPCKSPPEIS 938



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 57/256 (22%), Positives = 102/256 (39%), Gaps = 43/256 (16%)

Query: 356 SPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGS 415
           SP+  +C+E  ++ G   EL++    +  +  Y        +        C+P F + G 
Sbjct: 617 SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYY--------CNPRFLMKGP 668

Query: 416 SIILCLPNGLWSGSESYCRVR--TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLE 473
           + I C+ +G W+ +   C V   TC  + + +HG    S+    Y  +    C E + + 
Sbjct: 669 NKIQCV-DGEWT-TLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMI 726

Query: 474 GSDKLTCQGNSQWDGPEPRCVE----RHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSC 529
           G   +TC  +  W    P+CV     + C +  +   +I+  H   K+     +     C
Sbjct: 727 GHRSITCI-HGVWT-QLPQCVAIDKLKKCKSSNL---IILEEHLKNKKEFDHNSNIRYRC 781

Query: 530 R--QGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVT 587
           R  +G+I +          +G+W+  V  ++ +    P    P  I        +S N+T
Sbjct: 782 RGKEGWIHT-------VCINGRWDPEVNCSMAQIQLCPP---PPQI-------PNSHNMT 824

Query: 588 WQIPTAKDNSGEKVSV 603
               T     GEKVSV
Sbjct: 825 ---TTLNYRDGEKVSV 837


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  272 bits (695), Expect = 5e-72
 Identities = 149/408 (36%), Positives = 216/408 (52%), Gaps = 52/408 (12%)

Query: 1021 GSYQDEEGQLECKLCPSGMYTEYIHSRNISDC-KAQCKQGTYSYSGLET--CESCPLGTY 1077
            G+  +  G   C +C +G +T    S NI DC  A C  G   +  + +  CE CP G  
Sbjct: 310  GTCHNTHGGYNC-VCVNG-WTGEDCSENIDDCASAACFHGATCHDRVASFYCE-CPHG-- 364

Query: 1078 QPKFGSRSCLSCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGK 1137
                  R+ L C  N + +            PC EG    +              P  GK
Sbjct: 365  ------RTGLLCHLNDACISN----------PCNEGSNCDTN-------------PVNGK 395

Query: 1138 AFCLACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASL------GHIKKRHEISS 1191
            A C  CP   T P A S+ + ECS  ++    A + +    S       G+   R EI  
Sbjct: 396  AIC-TCPSGYTGP-ACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEID- 452

Query: 1192 QVFHECFFNPCHNSGTC-QQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLV 1250
               +EC  NPC N  TC  Q+G  + C+C  GY G+ CE + DEC+  PCL+NG C D +
Sbjct: 453  --VNECVSNPCQNDATCLDQIGE-FQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKI 509

Query: 1251 GEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNE 1310
             EF CECP+G+TG  C+ +++EC+S+PC N   C+DG   Y C C +G+ G HCE +++E
Sbjct: 510  NEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDE 569

Query: 1311 CQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCL 1370
            C  +PC +   C+D V  F C C PG+ G  C  N++EC SQPC++G TC+D  N++ C 
Sbjct: 570  CDPDPC-HYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCF 628

Query: 1371 CAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
            C  G TG +CE+N+++C S+PC +  TC+D+++ Y C C+PG++G  C
Sbjct: 629  CLKGTTGPNCEINLDDCASSPC-DSGTCLDKIDGYECACEPGYTGSMC 675



 Score =  254 bits (648), Expect = 1e-66
 Identities = 104/228 (45%), Positives = 147/228 (64%), Gaps = 5/228 (2%)

Query: 1197 CFFNPCHNSGTCQQ--LGRGYVCLCPLGYTGLKCETDIDECS--PLPCLNNGVCKDLVGE 1252
            C  NPC+    C    +    +C CP GYTG  C  D+DECS    PC + G C + +G 
Sbjct: 376  CISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGS 435

Query: 1253 FICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQ 1312
            F C+C  GYTG RCE ++NEC S+PC N   C+D +  ++C C+ G+ G+HCE   +EC 
Sbjct: 436  FECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECA 495

Query: 1313 SNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCA 1372
            S+PCL+N  C D++  F C+CP GF G  C  +VDEC S PCKNGA C DG N++ C+C 
Sbjct: 496  SSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCT 555

Query: 1373 AGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCET 1420
             G+TG+HCE++I+EC  +PC +  +C D + +++C C+PG++G  CET
Sbjct: 556  EGYTGTHCEVDIDECDPDPC-HYGSCKDGVATFTCLCRPGYTGHHCET 602



 Score =  252 bits (643), Expect = 5e-66
 Identities = 158/517 (30%), Positives = 222/517 (42%), Gaps = 134/517 (25%)

Query: 998  MCVNCPLGTYYNLEHFTCES--CRIGSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQ 1055
            +C     GT+  ++   C+   C  GS +D      C LC  G YT +    NI++C +Q
Sbjct: 553  VCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTC-LCRPG-YTGHHCETNINECSSQ 610

Query: 1056 ------------------CKQGTYSYS---GLETCES--CPLGTYQPKFGSRSCLSCPEN 1092
                              C +GT   +    L+ C S  C  GT   K     C   P  
Sbjct: 611  PCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGY 670

Query: 1093 TSTVKRGAVNISAC-GVPCPEGKFSRSGL--MPCHPCPRDYYQPNAGKAFCLACPFYGTT 1149
            T ++    +NI  C G PC  G     G+    C  CP  Y+ P      CL+       
Sbjct: 671  TGSMCN--INIDECAGNPCHNGGTCEDGINGFTCR-CPEGYHDPT-----CLS------- 715

Query: 1150 PFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQ 1209
                   + EC+S                                     NPC + G C+
Sbjct: 716  ------EVNECNS-------------------------------------NPCVH-GACR 731

Query: 1210 QLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEEN 1269
                GY C C  G++G  C+ + +EC   PC+N G CKD+   ++C C  G++G  C+ N
Sbjct: 732  DSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTN 791

Query: 1270 INECSSSPCLNKGICVDGVAGYRCTCV--------------------------------- 1296
            INEC+S+PCLN+G C+D VAGY+C C+                                 
Sbjct: 792  INECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYE 851

Query: 1297 -------KGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDEC 1349
                    G+ G  CE ++NEC  +PC + A C++  GG+ C C  G+ G  C  ++D+C
Sbjct: 852  SFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDC 911

Query: 1350 LSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKC 1409
               PC NG +C DG N+  C C  GF G+ CE +INEC S+PCRN A C D ++SY+C C
Sbjct: 912  RPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTC 971

Query: 1410 QPGFSGKRCETE-----QSTGFNLDFEVSGIYGYVML 1441
              GFSG  CE       +S+ FN    V GI  +  L
Sbjct: 972  PAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCL 1008



 Score =  252 bits (643), Expect = 5e-66
 Identities = 151/475 (31%), Positives = 210/475 (44%), Gaps = 58/475 (12%)

Query: 994  LRGRMCVNCPLGTYYNLEHFTCESCRIGSYQDEEGQLECKLCPSGMYTEYIHSRNISDCK 1053
            L+G    NC +    NL+      C  G+  D+    EC   P   YT  + + NI +C 
Sbjct: 630  LKGTTGPNCEI----NLDDCASSPCDSGTCLDKIDGYECACEPG--YTGSMCNINIDECA 683

Query: 1054 AQ-CKQGTYSYSGLE--TCESCPLGTYQP-------KFGSRSCL--SCPENTSTVKRGA- 1100
               C  G     G+   TC  CP G + P       +  S  C+  +C ++ +  K    
Sbjct: 684  GNPCHNGGTCEDGINGFTCR-CPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCD 742

Query: 1101 ---------VNISAC-GVPCPEG---KFSRSGLMPCHPCPRDYYQPNAGKAF--CLACPF 1145
                     +N + C   PC  G   K   SG + C  C   +  PN       C + P 
Sbjct: 743  PGWSGTNCDINNNECESNPCVNGGTCKDMTSGYV-C-TCREGFSGPNCQTNINECASNPC 800

Query: 1146 YGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQV------------ 1193
                      +  +C+       A  E V+ P +    +   E                 
Sbjct: 801  LNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTG 860

Query: 1194 ---------FHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNG 1244
                      +EC  +PC +  +CQ    GY C C  GY+G  CETDID+C P PC N G
Sbjct: 861  WQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGG 920

Query: 1245 VCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHC 1304
             C D +    C+C  G+ G  CEE+INEC+S PC N   C D V  Y CTC  GF G+HC
Sbjct: 921  SCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHC 980

Query: 1305 ETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGA 1364
            E    +C  + C N   C D +  F C CPPGF G+ C  +V+EC SQPC +G TC+DG 
Sbjct: 981  ENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGC 1040

Query: 1365 NSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
             S+RC C  G+TG +C+  ++ C S+PC+N   C      Y C+C  G++G  C+
Sbjct: 1041 GSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCD 1095



 Score =  246 bits (627), Expect = 4e-64
 Identities = 108/224 (48%), Positives = 131/224 (58%), Gaps = 3/224 (1%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            EC   PC N   C      Y C+C  GYTG  CE DIDEC P PC + G CKD V  F C
Sbjct: 531  ECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPC-HYGSCKDGVATFTC 589

Query: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP 1315
             C  GYTG  CE NINECSS PC + G C D    Y C C+KG  G +CE  +++C S+P
Sbjct: 590  LCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSP 649

Query: 1316 CLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGF 1375
            C ++  C D++ G+ C C PG+ G+ C  N+DEC   PC NG TC+DG N F C C  G+
Sbjct: 650  C-DSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGY 708

Query: 1376 TGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
                C   +NEC SNPC + A C D LN Y C C PG+SG  C+
Sbjct: 709  HDPTCLSEVNECNSNPCVHGA-CRDSLNGYKCDCDPGWSGTNCD 751



 Score =  235 bits (600), Expect = 5e-61
 Identities = 152/461 (32%), Positives = 206/461 (44%), Gaps = 68/461 (14%)

Query: 988  CRPGSVLRGRMCVNCPLGTY-----YNLEHFTCESCRIG-SYQDEEGQLECKLCPSGMYT 1041
            CR         CV CP G        ++       CR G S Q+  G   C  C +G Y+
Sbjct: 844  CRQSEDYESFSCV-CPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCH-CQAG-YS 900

Query: 1042 EYIHSRNISDCKAQ-CKQGTYSYSGLET--CESCP--LGTYQPKFGSRSCLSCPENTSTV 1096
                  +I DC+   C  G     G+ T  C+  P   GT+  +     C S P      
Sbjct: 901  GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEE-DINECASDPCRNGAN 959

Query: 1097 KRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRS 1156
                V+   C   CP G    SG+     C  +   P+  ++ C    F G T   G  S
Sbjct: 960  CTDCVDSYTC--TCPAGF---SGIH----CENN--TPDCTESSC----FNGGTCVDGINS 1004

Query: 1157 ITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYV 1216
             T               + PP   G   + H+++     EC   PC + GTCQ     Y 
Sbjct: 1005 FT--------------CLCPPGFTGSYCQ-HDVN-----ECDSQPCLHGGTCQDGCGSYR 1044

Query: 1217 CLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSS 1276
            C CP GYTG  C+  +  C   PC N G C     ++ CECPSG+TG  C+     C  +
Sbjct: 1045 CTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVA 1104

Query: 1277 P----------CLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQV 1326
                       C + G+CVD    + C C  G+ G +CE  V+EC  +PC N A C D +
Sbjct: 1105 AQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYL 1164

Query: 1327 GGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINE 1386
            GG+ CKC  G+ G  C + +DECLS PC+NG TC D  N+++C C  G  G HCE+N+++
Sbjct: 1165 GGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDD 1224

Query: 1387 C--------QSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
            C        +S  C N  TCVD++  YSC C PGF G+RCE
Sbjct: 1225 CNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCE 1265



 Score =  234 bits (598), Expect = 9e-61
 Identities = 152/455 (33%), Positives = 198/455 (43%), Gaps = 54/455 (11%)

Query: 988  CRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIGSYQDEEGQLECKLCPSGMYTEYIH-S 1046
            C PG   RG  C         ++     + CR G+   +        CP+G     IH  
Sbjct: 933  CLPG--FRGTFCEE-------DINECASDPCRNGANCTDCVDSYTCTCPAGF--SGIHCE 981

Query: 1047 RNISDC-KAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSCPENTSTVKRGAVNISA 1105
             N  DC ++ C  G               GT      S +CL  P  T +  +  VN   
Sbjct: 982  NNTPDCTESSCFNG---------------GTCVDGINSFTCLCPPGFTGSYCQHDVN-EC 1025

Query: 1106 CGVPCPEGKFSRSGLMPCH-PCPRDYYQPNAGKA--FCLACPFYGTTPFAGSRSITECSS 1162
               PC  G   + G       CP+ Y  PN      +C + P         + +   C  
Sbjct: 1026 DSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCEC 1085

Query: 1163 FSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLG 1222
             S       +  VP  S        E+++Q         C + G C   G  + C C  G
Sbjct: 1086 PSGWTGLYCD--VPSVSC-------EVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAG 1136

Query: 1223 YTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKG 1282
            YTG  CE  +DECSP PC N   C D +G + C+C +GY G  C E I+EC S PC N G
Sbjct: 1137 YTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGG 1196

Query: 1283 ICVDGVAGYRCTCVKGFVGLHCETEVNEC--------QSNPCLNNAVCEDQVGGFLCKCP 1334
             C+D    Y+C+C +G  G+HCE  V++C        +S  C NN  C DQVGG+ C CP
Sbjct: 1197 TCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCP 1256

Query: 1335 PGFLGTRCGKNVDECLSQPCKNGAT--CKDGANSFRCLCAAGFTGSHCELNINECQSNPC 1392
            PGF+G RC  +V+ECLS PC    T  C    N F C C AG TG  CE  IN C+  PC
Sbjct: 1257 PGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPC 1316

Query: 1393 RNQATCVDELNS---YSCKCQPGFSGKRCETEQST 1424
            +N  TC    N+   + CKC  GF G  CE +  T
Sbjct: 1317 KNGGTCAVASNTARGFICKCPAGFEGATCENDART 1351



 Score =  231 bits (588), Expect = 1e-59
 Identities = 101/263 (38%), Positives = 138/263 (52%), Gaps = 41/263 (15%)

Query: 1200 NPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECP- 1258
            N C N GTC     GY C+C  G+TG  C  +ID+C+   C +   C D V  F CECP 
Sbjct: 304  NACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPH 363

Query: 1259 --------------------------------------SGYTGQRCEENINECS--SSPC 1278
                                                  SGYTG  C ++++ECS  ++PC
Sbjct: 364  GRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPC 423

Query: 1279 LNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFL 1338
             + G C++ +  + C C++G+ G  CE +VNEC SNPC N+A C DQ+G F C C PG+ 
Sbjct: 424  EHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYE 483

Query: 1339 GTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATC 1398
            G  C  N DEC S PC +   C D  N F+C C  GFTG  C+ +++EC S PC+N A C
Sbjct: 484  GVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKC 543

Query: 1399 VDELNSYSCKCQPGFSGKRCETE 1421
            +D  N+Y+C C  G++G  CE +
Sbjct: 544  LDGPNTYTCVCTEGYTGTHCEVD 566



 Score =  210 bits (535), Expect = 2e-53
 Identities = 151/484 (31%), Positives = 197/484 (40%), Gaps = 70/484 (14%)

Query: 974  ADSNSLETKKASPFCRPGSVLRGRMCVN--------CP---LGTYYNLEHFTCES---CR 1019
            A  + +  +  +P C   S   G  CV+        CP    G+Y   +   C+S     
Sbjct: 973  AGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLH 1032

Query: 1020 IGSYQDEEGQLECKLCPSGMYT-----EYIHSRNISDCK--AQCKQGTYSYSGLETCESC 1072
             G+ QD  G   C  CP G YT       +H  + S CK   +C Q    Y     CE C
Sbjct: 1033 GGTCQDGCGSYRCT-CPQG-YTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYR----CE-C 1085

Query: 1073 PLGTYQPKFGSRSCLSCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQ 1132
            P G +   +     +SC                      E    R G+     C      
Sbjct: 1086 PSG-WTGLYCDVPSVSC----------------------EVAAQRQGVDVARLCQHGGLC 1122

Query: 1133 PNAGKAFCLACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEIS-S 1191
             +AG      C   G T       + ECS       A     +   S   +   H ++ S
Sbjct: 1123 VDAGNTHHCRCQA-GYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCS 1181

Query: 1192 QVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPL--------PCLNN 1243
            +   EC  +PC N GTC  L   Y C CP G  G+ CE ++D+C+P          C NN
Sbjct: 1182 EEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNN 1241

Query: 1244 GVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGI--CVDGVAGYRCTCVKGFVG 1301
            G C D VG + C CP G+ G+RCE ++NEC S+PC  +G   CV  V  + C C  G  G
Sbjct: 1242 GTCVDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTG 1301

Query: 1302 LHCETEVNECQSNPCLNNAVC---EDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGA 1358
              CE+ +N C+  PC N   C    +   GF+CKCP GF G  C  +   C S  C NG 
Sbjct: 1302 RRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGG 1361

Query: 1359 TCKDGANSFRCLCAAGFTGSHCELNINE--CQSNPCRNQATC--VDELNSYSCKCQPGFS 1414
            TC  G  S  CLC   FTG  C+   +      NPC NQ TC    E   Y C C   F+
Sbjct: 1362 TCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFN 1421

Query: 1415 GKRC 1418
            G  C
Sbjct: 1422 GLLC 1425



 Score =  197 bits (502), Expect = 1e-49
 Identities = 90/234 (38%), Positives = 122/234 (52%), Gaps = 5/234 (2%)

Query: 1190 SSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLP--CLNNGVCK 1247
            S Q    C  NPC N G C      Y+C CP  + G  C  D++EC   P  C + G C 
Sbjct: 137  SCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCH 196

Query: 1248 DLVGEFICECPSGYTGQRCEENINECSSSPCLNKGIC-VDGVAGYRCTCVKGFVGLHCET 1306
            + VG + C C + +TG  CE     CS SPC N G C   G   + C C+ GF G +CE 
Sbjct: 197  NEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEE 256

Query: 1307 EVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQP--CKNGATCKDGA 1364
             +++C  N C N   C D V  + C+CPP + G  C ++VDEC   P  C+NG TC +  
Sbjct: 257  NIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTH 316

Query: 1365 NSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
              + C+C  G+TG  C  NI++C S  C + ATC D + S+ C+C  G +G  C
Sbjct: 317  GGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLC 370



 Score =  192 bits (489), Expect = 4e-48
 Identities = 98/278 (35%), Positives = 133/278 (47%), Gaps = 50/278 (17%)

Query: 1192 QVFHECFFNP--CHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCK-- 1247
            Q  +EC   P  C + GTC      Y C+C   +TG  CE     CSP PC N G C+  
Sbjct: 177  QDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPT 236

Query: 1248 -DLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCET 1306
             D+  E  C C  G+TGQ CEENI++C  + C N G CVDGV  Y C C   + G +C  
Sbjct: 237  GDVTHE--CACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTE 294

Query: 1307 EVNECQ--SNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGA 1364
            +V+ECQ   N C N   C +  GG+ C C  G+ G  C +N+D+C S  C +GATC D  
Sbjct: 295  DVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRV 354

Query: 1365 NSFR---------------------------------------CLCAAGFTGSHCELNIN 1385
             SF                                        C C +G+TG  C  +++
Sbjct: 355  ASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVD 414

Query: 1386 ECQ--SNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
            EC   +NPC +   C++ L S+ C+C  G++G RCE +
Sbjct: 415  ECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEID 452



 Score =  192 bits (488), Expect = 5e-48
 Identities = 90/231 (38%), Positives = 126/231 (54%), Gaps = 10/231 (4%)

Query: 1197 CFFNPCHNSGTCQQLGR----GYVCLCPLGYTGLKCETDIDE-CSPLPCLNNGVCKDL-V 1250
            C   PC N+GTC  + R     Y C C LG++G  C T +D  C   PC N G C  L +
Sbjct: 63   CLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTL 122

Query: 1251 GEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNE 1310
             E+ C CP G++G+ C++  + C+S+PC N G C+   A Y C C   F G  C  +VNE
Sbjct: 123  TEYKCRCPPGWSGKSCQQ-ADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNE 181

Query: 1311 CQSNP--CLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCK-DGANSF 1367
            C   P  C +   C ++VG + C C     G  C +    C   PC+NG TC+  G  + 
Sbjct: 182  CGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTH 241

Query: 1368 RCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
             C C  GFTG +CE NI++C  N C+N   CVD +N+Y+C+C P ++G+ C
Sbjct: 242  ECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYC 292



 Score =  189 bits (481), Expect = 3e-47
 Identities = 87/229 (37%), Positives = 116/229 (50%), Gaps = 9/229 (3%)

Query: 1197 CFFNPCHNSGTCQQLG-RGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            C  NPC N GTC  L    Y C CP G++G  C+   D C+  PC N G C      +IC
Sbjct: 106  CLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQ-QADPCASNPCANGGQCLPFEASYIC 164

Query: 1256 ECPSGYTGQRCEENINECSSSP--CLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQS 1313
             CP  + G  C +++NEC   P  C + G C + V  YRC C     G +CE     C  
Sbjct: 165  HCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSP 224

Query: 1314 NPCLNNAVCEDQVGGFL--CKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLC 1371
            +PC N   C    G     C C PGF G  C +N+D+C    CKNG  C DG N++ C C
Sbjct: 225  SPCQNGGTCR-PTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRC 283

Query: 1372 AAGFTGSHCELNINECQ--SNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
               +TG +C  +++ECQ   N C+N  TC +    Y+C C  G++G+ C
Sbjct: 284  PPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDC 332



 Score =  146 bits (369), Expect = 3e-34
 Identities = 76/188 (40%), Positives = 98/188 (52%), Gaps = 10/188 (5%)

Query: 1240 CLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGIC--VD--GVAGYRCTC 1295
            CLN G C+   G   C C   + G RC++  N C S+PC N G C  VD  GVA Y C+C
Sbjct: 31   CLNGGKCEAANGTEACVCGGAFVGPRCQDP-NPCLSTPCKNAGTCHVVDRRGVADYACSC 89

Query: 1296 VKGFVGLHCETEV-NECQSNPCLNNAVCE-DQVGGFLCKCPPGFLGTRCGKNVDECLSQP 1353
              GF G  C T + N C +NPC N   C+   +  + C+CPPG+ G  C +  D C S P
Sbjct: 90   ALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSC-QQADPCASNP 148

Query: 1354 CKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNP--CRNQATCVDELNSYSCKCQP 1411
            C NG  C     S+ C C   F G  C  ++NEC   P  CR+  TC +E+ SY C C+ 
Sbjct: 149  CANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRA 208

Query: 1412 GFSGKRCE 1419
              +G  CE
Sbjct: 209  THTGPNCE 216



 Score =  102 bits (254), Expect = 7e-21
 Identities = 57/165 (34%), Positives = 72/165 (43%), Gaps = 13/165 (7%)

Query: 1263 GQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVC 1322
            G RC +         CLN G C        C C   FVG  C+ + N C S PC N   C
Sbjct: 21   GPRCSQ-----PGETCLNGGKCEAANGTEACVCGGAFVGPRCQ-DPNPCLSTPCKNAGTC 74

Query: 1323 E----DQVGGFLCKCPPGFLGTRCGKNVDE-CLSQPCKNGATCKD-GANSFRCLCAAGFT 1376
                   V  + C C  GF G  C   +D  CL+ PC+NG TC       ++C C  G++
Sbjct: 75   HVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWS 134

Query: 1377 GSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
            G  C+   + C SNPC N   C+    SY C C P F G  C  +
Sbjct: 135  GKSCQ-QADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQD 178



 Score = 82.4 bits (202), Expect = 7e-15
 Identities = 48/109 (44%), Positives = 56/109 (51%), Gaps = 20/109 (18%)

Query: 3475 PCQNGGICQRPNA-----CSCPEGWMGRLCEEPICILP---CLNGGRCVA---PYQCDCP 3523
            PCQNGG C RP       C+C  G+ G+ CEE I   P   C NGG CV     Y C CP
Sbjct: 226  PCQNGGTC-RPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCP 284

Query: 3524 PGWTGSRCHTAV--CQ---SPCLNGGKCVRPN---RCHCLSSWTGHNCS 3564
            P WTG  C   V  CQ   + C NGG C   +    C C++ WTG +CS
Sbjct: 285  PEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCS 333



 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 51/133 (38%), Positives = 63/133 (47%), Gaps = 24/133 (18%)

Query: 3450 GFLRSVCLENGTWTSPPICRAVCRFPCQNGGICQ----RPNACSCPEGWMGRLCEE--PI 3503
            GF   +CL        P+  A    PC+NGG C         C CP GW G+ C++  P 
Sbjct: 92   GFSGPLCLT-------PLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPC 144

Query: 3504 CILPCLNGGRCV---APYQCDCPPGWTGSRCHTAV--C-QSP--CLNGGKC---VRPNRC 3552
               PC NGG+C+   A Y C CPP + G  C   V  C Q P  C +GG C   V   RC
Sbjct: 145  ASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRC 204

Query: 3553 HCLSSWTGHNCSR 3565
             C ++ TG NC R
Sbjct: 205  VCRATHTGPNCER 217



 Score = 79.7 bits (195), Expect = 5e-14
 Identities = 43/109 (39%), Positives = 55/109 (50%), Gaps = 20/109 (18%)

Query: 3475 PCQNGGICQRPN-------ACSCPEGWMGRLCEEPI---CIL-PCLNGGRC----VAPYQ 3519
            PC+N G C   +       ACSC  G+ G LC  P+   C+  PC NGG C    +  Y+
Sbjct: 67   PCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYK 126

Query: 3520 CDCPPGWTGSRCHTA--VCQSPCLNGGKCV---RPNRCHCLSSWTGHNC 3563
            C CPPGW+G  C  A     +PC NGG+C+       CHC  S+ G  C
Sbjct: 127  CRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTC 175



 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 236/1033 (22%), Positives = 316/1033 (30%), Gaps = 255/1033 (24%)

Query: 2681 VSYTCNPGYELLGNPV---LICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGS 2737
            +S  CN G     NPV    IC     + G A S    EC L   P     +   T +GS
Sbjct: 377  ISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINT-LGS 435

Query: 2738 AVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEA-ISCKKPNPVMNGSIKGSNYTYLST 2796
               + C+            CL+        PRCE  ++    NP  N +   +    +  
Sbjct: 436  ---FECQ------------CLQGY----TGPRCEIDVNECVSNPCQNDA---TCLDQIGE 473

Query: 2797 LYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIE 2856
                C PGY     E   C+   N DE         C+S P   NG+       FQ E  
Sbjct: 474  FQCICMPGY-----EGVHCE--VNTDE---------CASSPCLHNGRCLDKINEFQCE-- 515

Query: 2857 YTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGV-TEGLDYGFMKEVTF 2915
              C  GF        +C  +     +TP     +C   P     V TEG   G   EV  
Sbjct: 516  --CPTGFT-----GHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYT-GTHCEVDI 567

Query: 2916 H------CHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGG 2969
                   CH G    G    TC           LC+P   G   +      +     HGG
Sbjct: 568  DECDPDPCHYGSCKDGVATFTC-----------LCRPGYTGHHCETNINECSSQPCRHGG 616

Query: 2970 HIQ-----YQCFPGYKLHGNSSRRCLSNGSWSGSSP----SCLP------CRCSTPVIEY 3014
              Q     Y CF    L G +   C  N     SSP    +CL       C C       
Sbjct: 617  TCQDRDNAYLCFC---LKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYT-- 671

Query: 3015 GTVNGTDFDCGKAARIQCFKGFKLL-GLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNA 3073
            G++   + D  + A   C  G     G++  TC     +       E   C S P +  A
Sbjct: 672  GSMCNINID--ECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGA 729

Query: 3074 FISETSSWKEN-----------VITYSCRSGYVIQG------SSDLICTEKGVWSQPYPV 3116
                 + +K +           +    C S   + G      +S  +CT +  +S P   
Sbjct: 730  CRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQ 789

Query: 3117 CEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDT-------------------- 3156
                 C S P +       +   Y    K  CL  YT  T                    
Sbjct: 790  TNINECASNPCLNQGTCIDDVAGY----KCNCLLPYTGATCEVVLAPCAPSPCRNGGECR 845

Query: 3157 ---DTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDF-SVNRQVSVSCAEGYT 3212
               D ++F+C     W  +       +C L         HG    + +      C  GY+
Sbjct: 846  QSEDYESFSCVCPTGWQGQTCEVDINECVLSP-----CRHGASCQNTHGGYRCHCQAGYS 900

Query: 3213 FEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYE 3272
              G N   C+ D         + C P  C    S   G          +T    C PG+ 
Sbjct: 901  --GRN---CETD--------IDDCRPNPCHNGGSCTDGI---------NTAFCDCLPGF- 937

Query: 3273 LEGNRERVCQEN---------RQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVY 3323
                R   C+E+         R  +          C  P  F       EN T       
Sbjct: 938  ----RGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSG--IHCENNTPDCTESS 991

Query: 3324 SCNRGYSLEGPSEAHCT-----ENGTWSHPVPLCKPNPC-----------PVPFVIPENA 3367
              N G  ++G +   C            H V  C   PC                 P+  
Sbjct: 992  CFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGY 1051

Query: 3368 LLSEKEFYVDQNVSIKCREGFLL-QGHGIITCNPDETWTQTSAKCEKISCGPPAHVENA- 3425
                 +  V    S  C+ G    Q H    C     WT        +SC   A  +   
Sbjct: 1052 TGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVD 1111

Query: 3426 IAR-----GVHYQYGDMITYSCYSGY-------MLEGFLRSVCLENGTWTS---PPICRA 3470
            +AR     G+    G+     C +GY       +++    S C    T T       C+ 
Sbjct: 1112 VARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKC 1171

Query: 3471 VCRF---------------PCQNGGIC-QRPNA--CSCPEGWMGRLCE----------EP 3502
            V  +               PCQNGG C   PN   CSCP G  G  CE          +P
Sbjct: 1172 VAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDP 1231

Query: 3503 ICILP-CLNGGRCV---APYQCDCPPGWTGSRCHTAV---CQSPCLNGG--KCV-RPN-- 3550
            +   P C N G CV     Y C CPPG+ G RC   V     +PC   G   CV R N  
Sbjct: 1232 VSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDF 1291

Query: 3551 RCHCLSSWTGHNC 3563
             C C +  TG  C
Sbjct: 1292 HCECRAGHTGRRC 1304



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 39/117 (33%), Positives = 52/117 (44%), Gaps = 25/117 (21%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPICILP-------------CLNGGRCVAP- 3517
            PC+NGG C + +    C CP GW G  C+ P                  C +GG CV   
Sbjct: 1067 PCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAG 1126

Query: 3518 --YQCDCPPGWTGSRCHTAVCQ---SPCLNGGKC---VRPNRCHCLSSWTGHNCSRK 3566
              + C C  G+TGS C   V +   SPC NG  C   +    C C++ + G NCS +
Sbjct: 1127 NTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEE 1183



 Score = 66.6 bits (161), Expect = 4e-10
 Identities = 40/106 (37%), Positives = 47/106 (44%), Gaps = 16/106 (15%)

Query: 3476 CQNGGICQRPNA---CSCPEGWMGRLCEEPI---CILPCLNGGRC---VAPYQCDCPPGW 3526
            CQNGG C   +    C C  GW G  C E I       C +G  C   VA + C+CP G 
Sbjct: 306  CQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGR 365

Query: 3527 TGSRCH--TAVCQSPCLNGGKC-VRPNR----CHCLSSWTGHNCSR 3565
            TG  CH   A   +PC  G  C   P      C C S +TG  CS+
Sbjct: 366  TGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQ 411



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 35/101 (34%), Positives = 42/101 (41%), Gaps = 13/101 (12%)

Query: 3475 PCQNGGICQ------RPNACSCPEGWMGRLCEEPICI---LPCLNGGRCVAPYQ---CDC 3522
            PC+NGG C       R   C CP G+ G  CE        L CLNGG C++  +   C C
Sbjct: 1315 PCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLC 1374

Query: 3523 PPGWTGSRCHTAVCQSPCLNGGKCVRPNRCHCLSSWTGHNC 3563
               +TG  C      SPCL G  C     C   S    + C
Sbjct: 1375 LGPFTGPECQFPA-SSPCLGGNPCYNQGTCEPTSESPFYRC 1414



 Score = 41.6 bits (96), Expect = 0.014
 Identities = 47/179 (26%), Positives = 64/179 (35%), Gaps = 21/179 (11%)

Query: 1712 VTYQCNNGYY--LLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYI 1769
            +T  C NG    LL  +   C     W+G   SC   D CA  + C+    CL  + SYI
Sbjct: 107  LTNPCRNGGTCDLLTLTEYKCRCPPGWSG--KSCQQADPCA-SNPCANGGQCLPFEASYI 163

Query: 1770 CSCVPPYTG-----DGKNCAE-PIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMG 1823
            C C P + G     D   C + P  C+  G   N   S            +C+  Y    
Sbjct: 164  CHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCS 223

Query: 1824 VTKI----TCLESGEWNH---LIPYCKAVSCGK--PAIPENGCIEELAFTFGSKVTYRC 1873
             +      TC  +G+  H    +P     +C +     P N C    A   G   TY C
Sbjct: 224  PSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVN-TYNC 281



 Score = 41.6 bits (96), Expect = 0.014
 Identities = 30/92 (32%), Positives = 39/92 (42%), Gaps = 9/92 (9%)

Query: 1730 CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKC 1789
            C     W G +   +D++EC + S C   ASC N  G Y C C   Y+  G+NC   I  
Sbjct: 855  CVCPTGWQGQTCE-VDINECVL-SPCRHGASCQNTHGGYRCHCQAGYS--GRNCETDIDD 910

Query: 1790 KAPGNPENGHSSGEIYTVGAEVTF-SCQEGYQ 1820
              P    NG S     T G    F  C  G++
Sbjct: 911  CRPNPCHNGGSC----TDGINTAFCDCLPGFR 938



 Score = 39.7 bits (91), Expect = 0.054
 Identities = 30/119 (25%), Positives = 39/119 (32%), Gaps = 55/119 (46%)

Query: 3502 PICILP---CLNGGRC-------------------------------------------- 3514
            P C  P   CLNGG+C                                            
Sbjct: 22   PRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRG 81

Query: 3515 VAPYQCDCPPGWTGSRCHT----AVCQSPCLNGGKC----VRPNRCHCLSSWTGHNCSR 3565
            VA Y C C  G++G  C T    A   +PC NGG C    +   +C C   W+G +C +
Sbjct: 82   VADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQ 140



 Score = 39.7 bits (91), Expect = 0.054
 Identities = 58/245 (23%), Positives = 87/245 (35%), Gaps = 53/245 (21%)

Query: 267 GSFIQDDMVHCSY---LCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTAC 323
           G   + D+  C     LC  G  C + +GS +C     H    CE+ Y        C+  
Sbjct: 172 GPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPY------VPCSPS 225

Query: 324 P---SGTYKPEGSPGGISSCIP------CPDENHTSPPGSTSPEDCVCREGYRA------ 368
           P    GT +P G      +C+P      C +EN    PG+       C +G         
Sbjct: 226 PCQNGGTCRPTGDVTHECACLPGFTGQNC-EENIDDCPGNNCKNGGACVDGVNTYNCRCP 284

Query: 369 ---SGQTC--ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLP 422
              +GQ C  ++  C  +    +NG    NT +  +N  C V    G D    +I  C  
Sbjct: 285 PEWTGQYCTEDVDECQLMPNACQNGGTCHNT-HGGYNCVC-VNGWTGED-CSENIDDCAS 341

Query: 423 NGLWSGSESYCRVRT----CPH-------------LRQPKHGHISCSTREMLYKTTCLVA 465
              + G+  + RV +    CPH             +  P +   +C T  +  K  C   
Sbjct: 342 AACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAIC--T 399

Query: 466 CDEGY 470
           C  GY
Sbjct: 400 CPSGY 404



 Score = 39.7 bits (91), Expect = 0.054
 Identities = 96/448 (21%), Positives = 140/448 (31%), Gaps = 69/448 (15%)

Query: 1628 CSDCPRLGGSVPHLRTASEDLK-PGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCE 1686
            C+      G+  H R AS   + P  +  L C      + NP     N+G      P   
Sbjct: 339  CASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPC----NEGSNCDTNPVNG 394

Query: 1687 RISCGVPPPLENGFHS--ADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSC- 1743
            +  C  P        S   D+   G+            LG     C    +     P C 
Sbjct: 395  KAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYT----GPRCE 450

Query: 1744 LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNC-AEPIKCKAPGNPENGHSSG 1802
            +DV+EC V + C   A+CL+  G + C C+P Y  +G +C     +C +     NG    
Sbjct: 451  IDVNEC-VSNPCQNDATCLDQIGEFQCICMPGY--EGVHCEVNTDECASSPCLHNGRCLD 507

Query: 1803 EI-----------------YTVGAEVTFSCQEGYQ-LMGVTKITCLESGEWNHLIPYCKA 1844
            +I                 Y V    +  C+ G + L G    TC+ +  +         
Sbjct: 508  KINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDI 567

Query: 1845 VSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVK 1904
              C         C + +A TF    T  C  GYT        C  N +   S P      
Sbjct: 568  DECDPDPCHYGSCKDGVA-TF----TCLCRPGYT-----GHHCETNINECSSQPCRHGGT 617

Query: 1905 CSSPENINNGKYILSGLT-------YLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPA 1957
            C   +N     + L G T           AS  CD+G  L      EC     +  +   
Sbjct: 618  CQDRDNAYL-CFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCN 676

Query: 1958 CHLVFCGEPPAIKDAVITG--NNFTFRNTVTY---------------TCKEGYTLAGLDT 2000
             ++  C   P           N FT R    Y                C  G     L+ 
Sbjct: 677  INIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNG 736

Query: 2001 IECLADGKWSRSDQQCLAVSCDEPPIVD 2028
             +C  D  WS ++       C+  P V+
Sbjct: 737  YKCDCDPGWSGTNCDINNNECESNPCVN 764



 Score = 39.3 bits (90), Expect = 0.071
 Identities = 63/301 (20%), Positives = 96/301 (31%), Gaps = 76/301 (25%)

Query: 230 ELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYLCDE-GKDCC 288
           ++N+  S P +     L    EF+ +                 + VHC    DE     C
Sbjct: 452 DVNECVSNPCQNDATCLDQIGEFQCICMPGY------------EGVHCEVNTDECASSPC 499

Query: 289 DRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENH 348
              G  +C      F+C C  G+ G   QY+                 +  C   P +N 
Sbjct: 500 LHNG--RCLDKINEFQCECPTGFTGHLCQYD-----------------VDECASTPCKNG 540

Query: 349 TSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHP 408
                  +   CVC EGY  +G  CE+        P                     CH 
Sbjct: 541 AKCLDGPNTYTCVCTEGY--TGTHCEVDIDECDPDP---------------------CHY 577

Query: 409 GFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQP-KHGHISCSTREMLYKTTCLVACD 467
           G    G +   CL    ++G      +  C    QP +HG  +C  R+  Y   C     
Sbjct: 578 GSCKDGVATFTCLCRPGYTGHHCETNINECS--SQPCRHGG-TCQDRDNAYLCFC----- 629

Query: 468 EGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYV 527
               L+G+    C+ N   D     C    C    + K   I  + C  +P   G++C +
Sbjct: 630 ----LKGTTGPNCEINLD-DCASSPCDSGTC----LDK---IDGYECACEPGYTGSMCNI 677

Query: 528 S 528
           +
Sbjct: 678 N 678



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 39/144 (27%), Positives = 53/144 (36%), Gaps = 35/144 (24%)

Query: 288 CDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGS-------------- 333
           C   G+CK    T  + C C +G+ G   Q     C S     +G+              
Sbjct: 762 CVNGGTCK--DMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLL 819

Query: 334 --PGG-----ISSCIPCPDENHTSPPGSTSPE--DCVCREGYRASGQTCEL-VHCPALKP 383
              G      ++ C P P  N      S   E   CVC  G++  GQTCE+ ++   L P
Sbjct: 820 PYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQ--GQTCEVDINECVLSP 877

Query: 384 PENGYFIQNTCNNHFNAACGVRCH 407
             +G   QNT         G RCH
Sbjct: 878 CRHGASCQNTHG-------GYRCH 894



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 37/145 (25%), Positives = 55/145 (37%), Gaps = 33/145 (22%)

Query: 1683 PHCER--ISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVS 1740
            P+CER  + C  P P +NG            VT++C     L G +   C +N       
Sbjct: 213  PNCERPYVPCS-PSPCQNGGTCRPT----GDVTHECA---CLPGFTGQNCEEN------- 257

Query: 1741 PSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAE--------PIKCKAP 1792
                 +D+C  G++C    +C++   +Y C C P +T  G+ C E        P  C+  
Sbjct: 258  -----IDDCP-GNNCKNGGACVDGVNTYNCRCPPEWT--GQYCTEDVDECQLMPNACQNG 309

Query: 1793 GNPENGHSSGEIYTVGAEVTFSCQE 1817
            G   N H       V       C E
Sbjct: 310  GTCHNTHGGYNCVCVNGWTGEDCSE 334



 Score = 37.4 bits (85), Expect = 0.27
 Identities = 27/87 (31%), Positives = 41/87 (47%), Gaps = 9/87 (10%)

Query: 1730 CTDNGSWNGVSPSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIK 1788
            CT    ++G  P+C  +++ECA  + C    +C++    Y C+C+ PYT  G  C   + 
Sbjct: 777  CTCREGFSG--PNCQTNINECA-SNPCLNQGTCIDDVAGYKCNCLLPYT--GATCEVVLA 831

Query: 1789 CKAPGNPENGHSSGEIYTVGAEVTFSC 1815
              AP    NG   GE        +FSC
Sbjct: 832  PCAPSPCRNG---GECRQSEDYESFSC 855



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 24/95 (25%), Positives = 36/95 (37%), Gaps = 21/95 (22%)

Query: 281 CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSC 340
           C  G + C+  G  KC    G FEC C +GY G   + +                 ++ C
Sbjct: 416 CSLGANPCEHAG--KCINTLGSFECQCLQGYTGPRCEID-----------------VNEC 456

Query: 341 IPCPDENHTSPPGSTSPEDCVCREGYRASGQTCEL 375
           +  P +N  +         C+C  GY   G  CE+
Sbjct: 457 VSNPCQNDATCLDQIGEFQCICMPGY--EGVHCEV 489



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 27/80 (33%), Positives = 35/80 (43%), Gaps = 20/80 (25%)

Query: 1708 AGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGS 1767
            AG+T   +C  GY     +  +C D             VDEC+  S C   A+C +  G 
Sbjct: 1125 AGNTHHCRCQAGY-----TGSYCEDL------------VDECSP-SPCQNGATCTDYLGG 1166

Query: 1768 YICSCVPPYTGDGKNCAEPI 1787
            Y C CV  Y   G NC+E I
Sbjct: 1167 YSCKCVAGY--HGVNCSEEI 1184



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 24/70 (34%), Positives = 29/70 (41%), Gaps = 13/70 (18%)

Query: 3476 CQNGGIC---QRPNACSCPEGWMGRLCEEPI---CI--LPCLNGGRCVAP-----YQCDC 3522
            C NGG C    R   C C   + G  C+ P    C+   PC N G C        Y+C C
Sbjct: 1357 CLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLC 1416

Query: 3523 PPGWTGSRCH 3532
            P  + G  CH
Sbjct: 1417 PAKFNGLLCH 1426



 Score = 35.8 bits (81), Expect = 0.78
 Identities = 63/277 (22%), Positives = 83/277 (29%), Gaps = 78/277 (28%)

Query: 288 CDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDEN 347
           C+   +C      G   C C  GY G     +   C  G    E +      CI      
Sbjct: 381 CNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHA----GKCI------ 430

Query: 348 HTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNN---------HF 398
                 +    +C C +GY  +G  CE+         +    + N C N          F
Sbjct: 431 -----NTLGSFECQCLQGY--TGPRCEI---------DVNECVSNPCQNDATCLDQIGEF 474

Query: 399 NAAC-----GVRCHPGFDLVGSSIILCLPNG--LWSGSESYCRVRT--CPHLRQPKHGHI 449
              C     GV C    D   SS   CL NG  L   +E  C   T    HL Q  +   
Sbjct: 475 QCICMPGYEGVHCEVNTDECASS--PCLHNGRCLDKINEFQCECPTGFTGHLCQ--YDVD 530

Query: 450 SCSTREMLYKTTCL-------VACDEGYR-------LEGSDKLTCQGNSQWDGP------ 489
            C++        CL         C EGY        ++  D   C   S  DG       
Sbjct: 531 ECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCL 590

Query: 490 -EPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTIC 525
             P     HC T         + + C  QP + G  C
Sbjct: 591 CRPGYTGHHCET---------NINECSSQPCRHGGTC 618



 Score = 35.8 bits (81), Expect = 0.78
 Identities = 55/259 (21%), Positives = 81/259 (31%), Gaps = 67/259 (25%)

Query: 288  CDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTAC-------------PSGTYKPEGSP 334
            C   G C+       F C+C  G+ G+  + +   C               G Y+     
Sbjct: 838  CRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQA 897

Query: 335  G--------GISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPEN 386
            G         I  C P P  N  S     +   C C  G+R +    ++  C A  P  N
Sbjct: 898  GYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINEC-ASDPCRN 956

Query: 387  GYFIQNTCNNHFNAAC-----GVRCHPG---------------FDLVGSSIILCLPNGLW 426
            G    + C + +   C     G+ C                   D + S   LC P   +
Sbjct: 957  GANCTD-CVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPG--F 1013

Query: 427  SGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRL---EGSDKLTCQGN 483
            +G  SYC           +H    C ++  L+  TC   C   YR    +G     CQ  
Sbjct: 1014 TG--SYC-----------QHDVNECDSQPCLHGGTCQDGCG-SYRCTCPQGYTGPNCQNL 1059

Query: 484  SQWDGPEP-----RCVERH 497
              W    P     +C + H
Sbjct: 1060 VHWCDSSPCKNGGKCWQTH 1078



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 70/316 (22%), Positives = 104/316 (32%), Gaps = 63/316 (19%)

Query: 288 CDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGT------------YKPEGSPG 335
           C   G+C+ G +   F C C +GY+      E   C S              YK +  PG
Sbjct: 687 CHNGGTCEDGING--FTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPG 744

Query: 336 --------GISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCE--LVHCPALKPPE 385
                     + C   P  N  +    TS   C CREG+  SG  C+  +  C +     
Sbjct: 745 WSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGF--SGPNCQTNINECAS----- 797

Query: 386 NGYFIQNTCNNHFNAACGVRCHPGFDLVGSS--IIL--CLPNGLWSGSESYCRVRTCPHL 441
           N    Q TC    +   G +C+      G++  ++L  C P+   +G E  CR       
Sbjct: 798 NPCLNQGTC---IDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGE--CR------- 845

Query: 442 RQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTF 501
           +   +   SC         TC V  +E          +CQ          RC   HC   
Sbjct: 846 QSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTH----GGYRC---HCQAG 898

Query: 502 QMPKDVIISPHNCGKQPAKFGTIC-------YVSCRQGFILSGVKEMLRCTTSGKWNVGV 554
              ++      +C   P   G  C       +  C  GF  +  +E +    S     G 
Sbjct: 899 YSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGA 958

Query: 555 QAAVCKDVEAPQINCP 570
               C  V++    CP
Sbjct: 959 NCTDC--VDSYTCTCP 972



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 108/522 (20%), Positives = 168/522 (32%), Gaps = 123/522 (23%)

Query: 1638 VPHLRTASEDLKPGSKVNLFCDPGFQLV--GNPVQYCLNQGQWTQPLPHCERI--SCGVP 1693
            VP +       + G  V   C  G   V  GN   +C  Q  +T    +CE +   C  P
Sbjct: 1096 VPSVSCEVAAQRQGVDVARLCQHGGLCVDAGN-THHCRCQAGYTGS--YCEDLVDECS-P 1151

Query: 1694 PPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMF-------CTDNGSW----NGVSPS 1742
             P +NG    D  Y G   + +C  GY+ +  S          C + G+     N    S
Sbjct: 1152 SPCQNGATCTD--YLGG-YSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCS 1208

Query: 1743 C----------LDVDECAVGSD-------CSEHASCLNVDGSYICSCVPPYTGDGKNCAE 1785
            C          ++VD+C    D       C  + +C++  G Y C+C P + G+   C  
Sbjct: 1209 CPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGE--RCEG 1266

Query: 1786 PIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQ-------LMGVTKITCLESGEWNHL 1838
             +  +   NP +   +        +    C+ G+        + G     C   G     
Sbjct: 1267 DVN-ECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVA 1325

Query: 1839 IPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRC-NKGYTLAGDKESSCLANSSWS--- 1894
                +   C  PA  E    E  A T GS    RC N G  ++G +  +CL    ++   
Sbjct: 1326 SNTARGFICKCPAGFEGATCENDARTCGS---LRCLNGGTCISGPRSPTCLCLGPFTGPE 1382

Query: 1895 ---------------HSPPVCEPV------KCSSPENINNGKYILSGLTYLSTASYSCDT 1933
                           ++   CEP       +C  P   N        L ++   S+    
Sbjct: 1383 CQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFN------GLLCHILDYSFGGGA 1436

Query: 1934 GYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFR----------N 1983
            G  +  P I E            AC L  C E    K   +  NN              N
Sbjct: 1437 GRDIPPPLIEE------------ACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFN 1484

Query: 1984 TVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIA 2043
                 C +        +++C         D QC +  C    + D    + A      + 
Sbjct: 1485 DPWKNCTQ--------SLQCWKYFSDGHCDSQCNSAGC----LFDGFDCQRAEGQCNPLY 1532

Query: 2044 FYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEK 2085
              YC D +S     Q   +A+ +W   +G D   C  H  E+
Sbjct: 1533 DQYCKDHFSDGHCDQGCNSAECEW---DGLD---CAEHVPER 1568



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 45/178 (25%), Positives = 58/178 (32%), Gaps = 48/178 (26%)

Query: 266  SGSFIQDDMVHCSYL-CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACP 324
            +GS+ +D +  CS   C  G  C D +G          + C C  GY+G     E   C 
Sbjct: 1138 TGSYCEDLVDECSPSPCQNGATCTDYLGG---------YSCKCVAGYHGVNCSEEIDECL 1188

Query: 325  S-------------GTYK---PEGSPG-----GISSCIPCPDENHTSPP--------GST 355
            S              TYK   P G+ G      +  C P  D    SP            
Sbjct: 1189 SHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQV 1248

Query: 356  SPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCN--NHFNAAC-----GVRC 406
                C C  G+   G+ CE      L  P +    QN     N F+  C     G RC
Sbjct: 1249 GGYSCTCPPGF--VGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRC 1304



 Score = 33.1 bits (74), Expect = 5.1
 Identities = 33/140 (23%), Positives = 46/140 (32%), Gaps = 27/140 (19%)

Query: 740 CTPDNTGVNCTLT--------CLEGYDFTEGSTDKYYCAYEDGVWKPTYTTEWPDCAKKR 791
           C P  +G NC +         C+ G    +  T  Y C   +G   P   T   +CA   
Sbjct: 741 CDPGWSGTNCDINNNECESNPCVNG-GTCKDMTSGYVCTCREGFSGPNCQTNINECASNP 799

Query: 792 FANHGFKSFEMFYKAARCDDTDLMKKFSEAFETTLGKMVPSFCSDAEDIDCRLEENLTKK 851
             N G    ++      C    L+       E  L    PS C +    +CR  E     
Sbjct: 800 CLNQGTCIDDVAGYKCNC----LLPYTGATCEVVLAPCAPSPCRNGG--ECRQSE----- 848

Query: 852 YCLEYNYDYENGFAIGPGGW 871
                  DYE+   + P GW
Sbjct: 849 -------DYESFSCVCPTGW 861



 Score = 33.1 bits (74), Expect = 5.1
 Identities = 52/233 (22%), Positives = 74/233 (31%), Gaps = 48/233 (20%)

Query: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG----------------DGKNCAEPI- 1787
            D+D+C   + C    SC +   +  C C+P + G                +G NC + + 
Sbjct: 907  DIDDCRP-NPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVD 965

Query: 1788 --KCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCL-----ESGEWNHLIP 1840
               C  P      H   E  T     +     G  + G+   TCL           H + 
Sbjct: 966  SYTCTCPAGFSGIHC--ENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVN 1023

Query: 1841 YCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCN--KGYTLAGDKESSCLANSSWSHSPP 1898
             C +  C      ++GC        GS   YRC   +GYT       +C     W  S P
Sbjct: 1024 ECDSQPCLHGGTCQDGC--------GS---YRCTCPQGYT-----GPNCQNLVHWCDSSP 1067

Query: 1899 VCEPVKCSSPENINNGKYILSGLT--YLSTASYSCDTGYSLQGPSIIECTASG 1949
                 KC         +   SG T  Y    S SC+     QG  +      G
Sbjct: 1068 CKNGGKCWQTHTQYRCE-CPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHG 1119


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score =  271 bits (692), Expect = 1e-71
 Identities = 154/454 (33%), Positives = 210/454 (46%), Gaps = 45/454 (9%)

Query: 988  CRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIGSYQDEEGQLECKLCPSGMYTEYIHSR 1047
            C+PG+       VNC +    N +      C  G   D   +  C   P   +T    + 
Sbjct: 633  CQPGT-----SGVNCEI----NFDDCASNPCIHGICMDGINRYSCVCSPG--FTGQRCNI 681

Query: 1048 NISDCKAQ-CKQGTYSYSGLETCES-CPLGTYQPKFGSR--SCLSCPENTSTVKRGAVNI 1103
            +I +C +  C++G    +G+      CP G + P   S+   CLS P        G    
Sbjct: 682  DIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGY 741

Query: 1104 SAC------GVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSI 1157
                     G+ C   K         +PC       N    +   C   G   +    +I
Sbjct: 742  KCLCDAGWVGINCEVDKNECLS----NPCQNGGTCDNLVNGYRCTCK-KGFKGYNCQVNI 796

Query: 1158 TECSS---------FSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTC 1208
             EC+S         F          V+P                V   C  NPC N+  C
Sbjct: 797  DECASNPCLNQGTCFDDISGYTCHCVLPYTGKN--------CQTVLAPCSPNPCENAAVC 848

Query: 1209 QQLGR--GYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRC 1266
            ++      Y CLC  G+ G +C  DIDEC   PC+N+G+C +  G ++CECP G++G  C
Sbjct: 849  KESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDC 908

Query: 1267 EENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQV 1326
            EE+I++C ++PC N G C+DGV  + C C+ GF G  C+T++NEC S PC N   C D V
Sbjct: 909  EEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYV 968

Query: 1327 GGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINE 1386
              + CKC  GF G  C  N++EC    C NG TC DG NSF CLC  GFTGS C   INE
Sbjct: 969  NSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINE 1028

Query: 1387 CQSNPCRNQATCVDELNSYSCKCQPGFSGKRCET 1420
            C S+PC N+ TCVD L +Y C C  G++GK C+T
Sbjct: 1029 CSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQT 1062



 Score =  264 bits (675), Expect = 1e-69
 Identities = 160/452 (35%), Positives = 207/452 (45%), Gaps = 53/452 (11%)

Query: 990  PGSVLRGRMCVNCPLGTYYNLEHFTCESCRIGSYQDEEGQLECKLCPSGMYTEYIHSRNI 1049
            PG    G  C+N P                 GSYQ +        CP G   +Y  S  +
Sbjct: 189  PGHCQHGGTCLNLP-----------------GSYQCQ--------CPQGFTGQYCDSLYV 223

Query: 1050 SDCKAQCKQG-TYSYSGLETCESCPLGTYQPKFGSRSCLSCPEN---TSTVKRGAVNISA 1105
                + C  G T   +G  T E   L  ++     R+   CP +      V    VN   
Sbjct: 224  PCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYN 283

Query: 1106 CGVPCPE--GKFSRSGLMPCHPCPRDYYQPNA---GKAFCLACPFYGTTPFAG------S 1154
            C  P P+  G+F    +  C        QPNA   G         YG     G      S
Sbjct: 284  CRCP-PQWTGQFCTEDVDEC------LLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCS 336

Query: 1155 RSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQ--LG 1212
             +I +C+  S T  +     V   S    + +  +   +   C  NPCH    C    L 
Sbjct: 337  ENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLN 396

Query: 1213 RGYVCLCPLGYTGLKCETDIDECSPL---PCLNNGVCKDLVGEFICECPSGYTGQRCEEN 1269
              Y+C CP GY G  C  D+DEC+     PC + G C +  G F CEC  GY G RCE +
Sbjct: 397  GQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMD 456

Query: 1270 INECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGF 1329
            INEC S PC N   C+D + G+ C C+ GF G+HCE E+NECQSNPC+NN  C D+V  F
Sbjct: 457  INECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRF 516

Query: 1330 LCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQS 1389
             C CPPGF G  C  ++D+C S PC NGA C D  N + C CA GFTG  CE NI+ C  
Sbjct: 517  QCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDP 576

Query: 1390 NPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
            +PC +   C D ++SY+C C PG+ G  C  +
Sbjct: 577  DPC-HHGQCQDGIDSYTCICNPGYMGAICSDQ 607



 Score =  244 bits (623), Expect = 1e-63
 Identities = 119/296 (40%), Positives = 158/296 (53%), Gaps = 47/296 (15%)

Query: 1191 SQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLV 1250
            SQV +EC  NPC + G C     GY CLC  G+ G+ CE D +EC   PC N G C +LV
Sbjct: 719  SQV-NECLSNPCIH-GNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLV 776

Query: 1251 GEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNE 1310
              + C C  G+ G  C+ NI+EC+S+PCLN+G C D ++GY C CV  + G +C+T +  
Sbjct: 777  NGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAP 836

Query: 1311 CQSNPCLNNAVCEDQVG--GFLCKCPPGFLGTRCGKNVDECLSQ---------------- 1352
            C  NPC N AVC++      + C C PG+ G RC  ++DEC+S+                
Sbjct: 837  CSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYM 896

Query: 1353 ----------------------PCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSN 1390
                                  PC+NG +C DG N+F CLC  GFTG  C+ ++NEC S 
Sbjct: 897  CECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSE 956

Query: 1391 PCRNQATCVDELNSYSCKCQPGFSGKRCETE-----QSTGFNLDFEVSGIYGYVML 1441
            PC+N  TC D +NSY+CKCQ GF G  CE       +S+ FN    V GI  +  L
Sbjct: 957  PCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCL 1012



 Score =  241 bits (616), Expect = 7e-63
 Identities = 101/232 (43%), Positives = 146/232 (62%), Gaps = 2/232 (0%)

Query: 1189 ISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKD 1248
            I S    EC+ +PC N G C  L  GY C C  G +G+ CE + D+C+  PC++ G+C D
Sbjct: 603  ICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIH-GICMD 661

Query: 1249 LVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEV 1308
             +  + C C  G+TGQRC  +I+EC+S+PC     C++GV G+RC C +G     C ++V
Sbjct: 662  GINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQV 721

Query: 1309 NECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFR 1368
            NEC SNPC++   C   + G+ C C  G++G  C  + +ECLS PC+NG TC +  N +R
Sbjct: 722  NECLSNPCIHGN-CTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYR 780

Query: 1369 CLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCET 1420
            C C  GF G +C++NI+EC SNPC NQ TC D+++ Y+C C   ++GK C+T
Sbjct: 781  CTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQT 832



 Score =  241 bits (615), Expect = 9e-63
 Identities = 98/224 (43%), Positives = 128/224 (57%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            EC   PC N G C      Y+C CP G++G+ CE DID+C   PC N G C D V  F C
Sbjct: 876  ECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSC 935

Query: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP 1315
             C  G+TG +C+ ++NEC S PC N G C D V  Y C C  GF G+HCE  +NEC  + 
Sbjct: 936  LCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESS 995

Query: 1316 CLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGF 1375
            C N   C D +  F C CP GF G+ C   ++EC S PC N  TC DG  ++RC C  G+
Sbjct: 996  CFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGY 1055

Query: 1376 TGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
            TG +C+  +N C  +PC+N+ TCV +     C C  G++G  C+
Sbjct: 1056 TGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCD 1099



 Score =  234 bits (598), Expect = 9e-61
 Identities = 138/439 (31%), Positives = 184/439 (41%), Gaps = 93/439 (21%)

Query: 1049 ISDCKAQCKQGTYSYS---GLETCESCPLGTYQPKFGSRSCLSCPENTSTVKRGAVNISA 1105
            ++  +  CK+G   Y+    ++ C S P       F   S  +C                
Sbjct: 776  VNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCH--------------- 820

Query: 1106 CGVPCPEGKFSRSGLMPCHPCPRDYY-----QPNAGKAFCLACPFYGTTPFAGSR---SI 1157
            C +P   GK  ++ L PC P P +        PN     CL  P +      G R    I
Sbjct: 821  CVLPYT-GKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGW-----QGQRCTIDI 874

Query: 1158 TECSS-------FSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQ 1210
             EC S              +     PP   G          +   +C  NPC N G+C  
Sbjct: 875  DECISKPCMNHGLCHNTQGSYMCECPPGFSGMD------CEEDIDDCLANPCQNGGSCMD 928

Query: 1211 LGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENI 1270
                + CLC  G+TG KC+TD++EC   PC N G C D V  + C+C +G+ G  CE NI
Sbjct: 929  GVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNI 988

Query: 1271 NECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFL 1330
            NEC+ S C N G CVDG+  + C C  GF G  C  E+NEC S+PCLN   C D +G + 
Sbjct: 989  NECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYR 1048

Query: 1331 CKCPPGFLGTRCGKNVDECLSQPCKNGATCK----------------------------- 1361
            C CP G+ G  C   V+ C   PCKN  TC                              
Sbjct: 1049 CSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIA 1108

Query: 1362 -------------------DGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDEL 1402
                               +  N+  C C  G+TGS+CE  ++EC SNPC++ ATC D +
Sbjct: 1109 ASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFI 1168

Query: 1403 NSYSCKCQPGFSGKRCETE 1421
              Y C+C PG+ G  CE E
Sbjct: 1169 GGYRCECVPGYQGVNCEYE 1187



 Score =  234 bits (598), Expect = 9e-61
 Identities = 132/404 (32%), Positives = 179/404 (44%), Gaps = 75/404 (18%)

Query: 1069 CESCPLGTYQPKFGSRSCLSCPENTSTVKRGAVNISAC-GVPCPEGKFSRS--GLMPCHP 1125
            CE+  +    P F S +CL  P      +R  ++I  C   PC       +  G   C  
Sbjct: 842  CENAAVCKESPNFESYTCLCAPGWQG--QRCTIDIDECISKPCMNHGLCHNTQGSYMCE- 898

Query: 1126 CPRDYYQPNAGKAF--CLACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHI 1183
            CP  +   +  +    CLA P        GS     C    +TFS     +  P   G  
Sbjct: 899  CPPGFSGMDCEEDIDDCLANPCQN----GGS-----CMDGVNTFSC----LCLPGFTG-- 943

Query: 1184 KKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNN 1243
                +      +EC   PC N GTC      Y C C  G+ G+ CE +I+EC+   C N 
Sbjct: 944  ----DKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNG 999

Query: 1244 GVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLH 1303
            G C D +  F C CP G+TG  C   INECSS PCLN+G CVDG+  YRC+C  G+ G +
Sbjct: 1000 GTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKN 1059

Query: 1304 CETEVNECQSNPCLNNAVCEDQ------------VGGF---------------------- 1329
            C+T VN C  +PC N   C  +             G +                      
Sbjct: 1060 CQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHL 1119

Query: 1330 --------------LCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGF 1375
                           C+CP G+ G+ C + +DEC S PC++GATC D    +RC C  G+
Sbjct: 1120 CQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGY 1179

Query: 1376 TGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
             G +CE  ++ECQ+ PC+N  TC+D +N + C C PG  G  CE
Sbjct: 1180 QGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCE 1223



 Score =  231 bits (588), Expect = 1e-59
 Identities = 105/261 (40%), Positives = 140/261 (53%), Gaps = 39/261 (14%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            +C   PC N   C     GY C C  G+TG+ CE +ID C P PC ++G C+D +  + C
Sbjct: 535  DCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPC-HHGQCQDGIDSYTC 593

Query: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP 1315
             C  GY G  C + I+EC SSPCLN G C+D V GY+C C  G  G++CE   ++C SNP
Sbjct: 594  ICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNP 653

Query: 1316 CLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFR------- 1368
            C+ + +C D +  + C C PGF G RC  ++DEC S PC+ GATC +G N FR       
Sbjct: 654  CI-HGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGP 712

Query: 1369 ------------------------------CLCAAGFTGSHCELNINECQSNPCRNQATC 1398
                                          CLC AG+ G +CE++ NEC SNPC+N  TC
Sbjct: 713  HHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTC 772

Query: 1399 VDELNSYSCKCQPGFSGKRCE 1419
             + +N Y C C+ GF G  C+
Sbjct: 773  DNLVNGYRCTCKKGFKGYNCQ 793



 Score =  229 bits (584), Expect = 4e-59
 Identities = 149/478 (31%), Positives = 203/478 (42%), Gaps = 56/478 (11%)

Query: 988  CRPGSVLRGRMCVNCPLGTYYNLEHFTC--------ESCRI-------------GSYQDE 1026
            C P       +C   P     N E +TC        + C I             G   + 
Sbjct: 837  CSPNPCENAAVCKESP-----NFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNT 891

Query: 1027 EGQLECKLCPSGMYTEYIHSRNISDCKAQ-CKQGTYSYSGLETCESCPLGTY---QPKFG 1082
            +G   C+ CP G ++      +I DC A  C+ G     G+ T     L  +   + +  
Sbjct: 892  QGSYMCE-CPPG-FSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTD 949

Query: 1083 SRSCLSCPENTSTVKRGAVNISACGVPCP-EGKFSRSGLMPC--HPCPRDYYQPNAGKAF 1139
               CLS P          VN   C      +G    + +  C    C       +   +F
Sbjct: 950  MNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSF 1009

Query: 1140 CLACPFYGTTPFAGSRSITECSSF----SSTFSAAEESVVPPASLGHIKKRHEISSQVFH 1195
               CP   T  F     I ECSS       T      +      LG+  K  +    + +
Sbjct: 1010 SCLCPVGFTGSFC-LHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQT---LVN 1065

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLP----------CLNNGV 1245
             C  +PC N GTC Q      CLCP G+ G  C+     C              C ++GV
Sbjct: 1066 LCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGV 1125

Query: 1246 CKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCE 1305
            C +      C+CP GYTG  CEE ++EC+S+PC +   C D + GYRC CV G+ G++CE
Sbjct: 1126 CINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCE 1185

Query: 1306 TEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQP-CKNGATCKDGA 1364
             EV+ECQ+ PC N   C D V  F C CPPG  G  C +N+D+C   P C NG  C D  
Sbjct: 1186 YEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRI 1245

Query: 1365 NSFRCLCAAGFTGSHCELNINECQSNPCRNQAT--CVDELNSYSCKCQPGFSGKRCET 1420
              + C C  GF G  CE +INEC SNPC ++ +  C+   N Y C C+  F+G+ CET
Sbjct: 1246 GGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCET 1303



 Score =  228 bits (580), Expect = 1e-58
 Identities = 96/225 (42%), Positives = 131/225 (58%), Gaps = 6/225 (2%)

Query: 1202 CHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGY 1261
            C +SG C   G  + C CPLGYTG  CE  +DEC+  PC +   C D +G + CEC  GY
Sbjct: 1120 CQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGY 1179

Query: 1262 TGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP-CLNNA 1320
             G  CE  ++EC + PC N G C+D V  ++C+C  G  GL CE  +++C   P CLN  
Sbjct: 1180 QGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGG 1239

Query: 1321 VCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGAT--CKDGANSFRCLCAAGFTGS 1378
             C D++GG+ C+C PGF G RC  +++ECLS PC +  +  C    N + C+C + FTG 
Sbjct: 1240 QCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGR 1299

Query: 1379 HCELNINECQSNPCRNQATCVDELN---SYSCKCQPGFSGKRCET 1420
            HCE  ++ C   PC N  TC    N    + C+C PGFSG RC++
Sbjct: 1300 HCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQS 1344



 Score =  214 bits (544), Expect = 2e-54
 Identities = 137/461 (29%), Positives = 189/461 (40%), Gaps = 88/461 (19%)

Query: 1032 CKLCPSGMYTEYIHSRNISDCKAQCKQG----TYSYSGLETC--------ESCPLGTYQP 1079
            CK CP G   EY   R+  + K +C+ G      +  G  TC        E C   T  P
Sbjct: 51   CK-CPEGFLGEYCQHRDPCE-KNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 108

Query: 1080 KFGSRSCL---SCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAG 1136
             F SR CL   +C   +         +   G  C       S     HPC          
Sbjct: 109  CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLS-----HPCANGSTCTTVA 163

Query: 1137 KAFCLACPFYGTTPFAGSR---SITEC--------SSFSSTFSAAEESVVPPASLGHIKK 1185
              F   C     T F G +    + EC                 + +   P    G    
Sbjct: 164  NQFSCKC----LTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTG---- 215

Query: 1186 RHEISSQVFHECFFNPCHNSGTCQQLGR-GYVCLCPLGYTGLKCETDIDECSPLPCLNNG 1244
              +    ++  C  +PC N GTC+Q G   + C C  G+ G  CE +ID+C    C N G
Sbjct: 216  --QYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGG 273

Query: 1245 VCKDLVGEFICECPSGYTGQRCEENINECSSSP--CLNKGICVDGVAGYRCTCVKGFVGL 1302
            VC D V  + C CP  +TGQ C E+++EC   P  C N G C +   GY C CV G+ G 
Sbjct: 274  VCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGD 333

Query: 1303 HCETEVNECQ-------------------------------------SNPCLNNAVCEDQ 1325
             C   +++C                                      SNPC   A+C+  
Sbjct: 334  DCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTN 393

Query: 1326 V--GGFLCKCPPGFLGTRCGKNVDECL---SQPCKNGATCKDGANSFRCLCAAGFTGSHC 1380
               G ++C CP G+ G  C ++VDEC    S PC++   C +   +F C C  G+ G  C
Sbjct: 394  PLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRC 453

Query: 1381 ELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
            E++INEC S+PC+N ATC+D++  ++C C PGF G  CE E
Sbjct: 454  EMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELE 494



 Score =  213 bits (541), Expect = 4e-54
 Identities = 148/473 (31%), Positives = 186/473 (39%), Gaps = 109/473 (23%)

Query: 1009 NLEHFTCESC-RIGSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQ-CKQGTYSYSGL 1066
            N+   T  SC   G+  D      C LCP G +T       I++C +  C        GL
Sbjct: 987  NINECTESSCFNGGTCVDGINSFSC-LCPVG-FTGSFCLHEINECSSHPCLNEGTCVDGL 1044

Query: 1067 ETCE-SCPLG----------------------TYQPKFGSRSCLSCPENTSTVKRGAVNI 1103
             T   SCPLG                      T   K     CL CP   +       N+
Sbjct: 1045 GTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCL-CPSGWAGAYCDVPNV 1103

Query: 1104 SACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITECSSF 1163
            S C +       SR G++  H C       NAG      CP                   
Sbjct: 1104 S-CDIAA-----SRRGVLVEHLCQHSGVCINAGNTHYCQCPL------------------ 1139

Query: 1164 SSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGY 1223
              T S  EE +                     EC  NPC +  TC     GY C C  GY
Sbjct: 1140 GYTGSYCEEQL--------------------DECASNPCQHGATCSDFIGGYRCECVPGY 1179

Query: 1224 TGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSP-CLNKG 1282
             G+ CE ++DEC   PC N G C DLV  F C CP G  G  CEENI++C+  P CLN G
Sbjct: 1180 QGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGG 1239

Query: 1283 ICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAV--CEDQVGGFLCKCPPGFLGT 1340
             C+D + GY C C+ GF G  CE ++NEC SNPC +     C      +LC C   F G 
Sbjct: 1240 QCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGR 1299

Query: 1341 RCGKNVDECLSQPCKNGATCKDGAN---SFRCLCAAGFTGSHCELNINE----------- 1386
             C   VD C   PC NG TC   +N    F C C  GF+G+ C+ +  +           
Sbjct: 1300 HCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVH 1359

Query: 1387 ------------------CQSNPCRNQATCVDELNS--YSCKCQPGFSGKRCE 1419
                              C S+PC++  +C  +     YSC+C P FSG RCE
Sbjct: 1360 TASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCE 1412



 Score =  210 bits (535), Expect = 2e-53
 Identities = 91/231 (39%), Positives = 132/231 (57%), Gaps = 4/231 (1%)

Query: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECS-PLPCLNNGVCKDLVGEFIC 1255
            C  +PC N  TC  +   + C C  G+TG KCETD++EC  P  C + G C +L G + C
Sbjct: 148  CLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQC 207

Query: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVD-GVAGYRCTCVKGFVGLHCETEVNECQSN 1314
            +CP G+TGQ C+     C+ SPC+N G C   G   + C C+ GF G  CE  +++C ++
Sbjct: 208  QCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNH 267

Query: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQP--CKNGATCKDGANSFRCLCA 1372
             C N  VC D V  + C+CPP + G  C ++VDECL QP  C+NG TC +    + C+C 
Sbjct: 268  RCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCV 327

Query: 1373 AGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQS 1423
             G++G  C  NI++C    C   +TC+D + S+SC C  G +G  C  + +
Sbjct: 328  NGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDA 378



 Score =  140 bits (352), Expect = 3e-32
 Identities = 71/189 (37%), Positives = 96/189 (50%), Gaps = 9/189 (4%)

Query: 1239 PCLNNGVCKDLV-GEFICECPSGYTGQRCEENINECSSSPCLNKGICVDG--VAGYRCTC 1295
            PC+N G+C     G   C+CP G+ G+ C+   + C  + C N G CV    +    C C
Sbjct: 34   PCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRC 92

Query: 1296 VKGFVGLHCETEVNE--CQSNPCLNNAVCED-QVGGFLCKCPPGFLGTRCGKNVDECLSQ 1352
              GF G  C+   +     S PCLN   C       + C C  GF G  C +  D CLS 
Sbjct: 93   ASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSH 151

Query: 1353 PCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQ-SNPCRNQATCVDELNSYSCKCQP 1411
            PC NG+TC   AN F C C  GFTG  CE ++NEC     C++  TC++   SY C+C  
Sbjct: 152  PCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQ 211

Query: 1412 GFSGKRCET 1420
            GF+G+ C++
Sbjct: 212  GFTGQYCDS 220



 Score =  122 bits (307), Expect = 5e-27
 Identities = 124/457 (27%), Positives = 179/457 (39%), Gaps = 81/457 (17%)

Query: 1001 NCPLG-------TYYNL-EHFTCESCRIGSYQDEEGQLECKLCPSGMYTEYIHSRNISDC 1052
            +CPLG       T  NL     C++   G+   ++ + +C LCPSG    Y    N+S  
Sbjct: 1050 SCPLGYTGKNCQTLVNLCSRSPCKNK--GTCVQKKAESQC-LCPSGWAGAYCDVPNVSCD 1106

Query: 1053 KAQCKQGTY-----SYSGL-------ETCESCPLGTYQPKFGSRSCLSCPENTSTVKRGA 1100
             A  ++G        +SG+         C+ CPLG Y   +       C  N    + GA
Sbjct: 1107 IAASRRGVLVEHLCQHSGVCINAGNTHYCQ-CPLG-YTGSYCEEQLDECASNPC--QHGA 1162

Query: 1101 VNISACG------VPCPEGKFSRSGLMPCH--PCPRDYYQPNAGKAFCLACPFYGTTPFA 1152
                  G      VP  +G      +  C   PC       +    F  +CP  GT    
Sbjct: 1163 TCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCP-PGTRGLL 1221

Query: 1153 GSRSITECSSFSSTFSAAE--------ESVVPPASLGHIKKRHEISSQVFHECFFNPCHN 1204
               +I +C+      +  +             P   G      E      +EC  NPC +
Sbjct: 1222 CEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAG------ERCEGDINECLSNPCSS 1275

Query: 1205 SGT--CQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVC---KDLVGEFICECPS 1259
             G+  C QL   Y+C+C   +TG  CET +D C  +PCLN G C    ++   FIC CP 
Sbjct: 1276 EGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPP 1335

Query: 1260 GYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNN 1319
            G++G RC+   + C    C     CV   +G RC C        CE   + C S+PC + 
Sbjct: 1336 GFSGARCQ---SSCGQVKCRKGEQCVHTASGPRCFCPS---PRDCE---SGCASSPCQHG 1386

Query: 1320 AVC--EDQVGGFLCKCPPGFLGTRC-------GKNVDECLSQPCKNGA---TCKDGANSF 1367
              C  + Q   + C+C P F G+RC             CLSQ C + A    C +  NS 
Sbjct: 1387 GSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSH 1446

Query: 1368 RCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNS 1404
             C     + G  C L +    +N C +   C D +N+
Sbjct: 1447 AC----QWDGGDCSLTMENPWAN-CSSPLPCWDYINN 1478



 Score = 76.3 bits (186), Expect = 5e-13
 Identities = 110/463 (23%), Positives = 163/463 (35%), Gaps = 95/463 (20%)

Query: 3148 CLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSC 3207
            C  G T  T  + F+C+    +  ++      +C +P +  H    G   ++       C
Sbjct: 153  CANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQH---GGTCLNLPGSYQCQC 209

Query: 3208 AEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQC 3267
             +G+T +         D  + P      C+P  C    +         + T + T    C
Sbjct: 210  PQGFTGQ-------YCDSLYVP------CAPSPCVNGGT--------CRQTGDFTFECNC 248

Query: 3268 EPGYELEGNRERV--CQENRQWSGGVAI--CKETRCETPLEFLNG--KADIENRTTGPNV 3321
             PG+E       +  C  +R  +GGV +       C  P ++       D++     PN 
Sbjct: 249  LPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNA 308

Query: 3322 VYS---C---NRGYS---LEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEK 3372
              +   C   N GY    + G S   C+EN         C P    +  V   + +  E 
Sbjct: 309  CQNGGTCANRNGGYGCVCVNGWSGDDCSENID-DCAFASCTPGSTCIDRVASFSCMCPEG 367

Query: 3373 EFYV-----DQNVSIKCREGFL-----LQGHGIITCNPD---ETWTQTSAKCEKISCGPP 3419
            +  +     D  +S  C +G L     L G  I TC         T+   +C   +  P 
Sbjct: 368  KAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPC 427

Query: 3420 AHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRA---VCRF-P 3475
             H    +     +         C  GY                 + P C      C   P
Sbjct: 428  EHAGKCVNTDGAFHC------ECLKGY-----------------AGPRCEMDINECHSDP 464

Query: 3476 CQNGGICQRPNA---CSCPEGWMGRLCEEPICIL---PCLNGGRCVAP---YQCDCPPGW 3526
            CQN   C        C C  G+ G  CE  I      PC+N G+CV     +QC CPPG+
Sbjct: 465  CQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGF 524

Query: 3527 TGSRCHTAV--CQS-PCLNGGKCV-RPN--RCHCLSSWTGHNC 3563
            TG  C   +  C S PCLNG KC+  PN   C C + +TG  C
Sbjct: 525  TGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLC 567



 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 42/108 (38%), Positives = 52/108 (48%), Gaps = 18/108 (16%)

Query: 3475 PCQNGGICQRPN----ACSCPEGWMGRLCEEPICILP---CLNGGRCVA---PYQCDCPP 3524
            PC NGG C++       C+C  G+ G  CE  I   P   C NGG CV     Y C CPP
Sbjct: 229  PCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPP 288

Query: 3525 GWTGSRCHTAVCQ-----SPCLNGGKCVRPN---RCHCLSSWTGHNCS 3564
             WTG  C   V +     + C NGG C   N    C C++ W+G +CS
Sbjct: 289  QWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCS 336



 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 43/104 (41%), Positives = 53/104 (50%), Gaps = 15/104 (14%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPI--CIL-PCLNGGRC---VAPYQCDCPPG 3525
            PC N G+C        C CP G+ G  CEE I  C+  PC NGG C   V  + C C PG
Sbjct: 881  PCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPG 940

Query: 3526 WTGSRCHTAV--CQS-PCLNGGKC---VRPNRCHCLSSWTGHNC 3563
            +TG +C T +  C S PC NGG C   V    C C + + G +C
Sbjct: 941  FTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHC 984



 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 42/103 (40%), Positives = 50/103 (48%), Gaps = 15/103 (14%)

Query: 3476 CQNGGICQ---RPNACSCPEGWMGRLCEEPI---CILPCLNGGRCV---APYQCDCPPGW 3526
            C NGG C       +C CP G+ G  C   I      PCLN G CV     Y+C CP G+
Sbjct: 996  CFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGY 1055

Query: 3527 TGSRCHTAV---CQSPCLNGGKCVR---PNRCHCLSSWTGHNC 3563
            TG  C T V    +SPC N G CV+    ++C C S W G  C
Sbjct: 1056 TGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYC 1098



 Score = 73.2 bits (178), Expect = 4e-12
 Identities = 47/146 (32%), Positives = 62/146 (42%), Gaps = 26/146 (17%)

Query: 3437 MITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGICQ---RPNACSCPEG 3493
            M++   Y      GF    C     WT      A    PC NG  C       +C C  G
Sbjct: 123  MLSRDTYECTCQVGFTGKEC----QWTD-----ACLSHPCANGSTCTTVANQFSCKCLTG 173

Query: 3494 WMGRLCEEPI--CILP--CLNGGRCV---APYQCDCPPGWTGSRC---HTAVCQSPCLNG 3543
            + G+ CE  +  C +P  C +GG C+     YQC CP G+TG  C   +     SPC+NG
Sbjct: 174  FTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNG 233

Query: 3544 GKCVRPN----RCHCLSSWTGHNCSR 3565
            G C +       C+CL  + G  C R
Sbjct: 234  GTCRQTGDFTFECNCLPGFEGSTCER 259



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 43/107 (40%), Positives = 54/107 (50%), Gaps = 18/107 (16%)

Query: 3475 PCQNGGIC---QRPNACSCPEGWMGRLCEEPI--CIL--PCLNGGRC---VAPYQCDCPP 3524
            PCQNGG C        CSCP G  G LCEE I  C     CLNGG+C   +  Y C C P
Sbjct: 1195 PCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLP 1254

Query: 3525 GWTGSRCHTAV---CQSPCLNGGK--CVRPNR---CHCLSSWTGHNC 3563
            G+ G RC   +     +PC + G   C++      C C S++TG +C
Sbjct: 1255 GFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHC 1301



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 40/109 (36%), Positives = 48/109 (44%), Gaps = 20/109 (18%)

Query: 3475 PCQNGGIC----QRPNACSCPEGWMGRLCE--EPICILPCLNGGRCVAPYQ-----CDCP 3523
            PC N G+C         C CPEG++G  C+  +P     C NGG CVA        C C 
Sbjct: 34   PCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCA 93

Query: 3524 PGWTGSRC-----HTAVCQSPCLNGGKCVRPNR----CHCLSSWTGHNC 3563
             G+TG  C     H      PCLNGG C   +R    C C   +TG  C
Sbjct: 94   SGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC 142



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 193/846 (22%), Positives = 283/846 (33%), Gaps = 202/846 (23%)

Query: 2859 CNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMK------- 2911
            C+ G   +G  S  C+ N  + GA        C + P L +G    L  G+         
Sbjct: 579  CHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTS 638

Query: 2912 ----EVTFH------CHEGYILHGAPKLTCQSDGNW-----DAEIPLCKPVNCGPPEDLA 2956
                E+ F       C  G  + G  + +C     +     + +I  C    C       
Sbjct: 639  GVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCI 698

Query: 2957 HGFPNGFSFI--HGGHIQY------QCFPGYKLHGN-----SSRRCLSNGSWSGSSPSCL 3003
            +G  NGF  I   G H         +C     +HGN     S  +CL +  W G +    
Sbjct: 699  NGV-NGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVD 757

Query: 3004 PCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLG-------------LSEITCEADG 3050
               C +   + G   GT  +     R  C KGFK                L++ TC  D 
Sbjct: 758  KNECLSNPCQNG---GTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDD- 813

Query: 3051 QWSSGFP-HCEHTSCGS------LPMIPNAFISETSSWKE--NVITYSCRSGYVIQGSSD 3101
               SG+  HC     G        P  PN      +  KE  N  +Y+C      QG   
Sbjct: 814  --ISGYTCHCVLPYTGKNCQTVLAPCSPNP-CENAAVCKESPNFESYTCLCAPGWQGQRC 870

Query: 3102 LICTEKGVWSQP---YPVCEPLS----CGSPPS-------------VANAVATG-EAHTY 3140
             I  ++ + S+P   + +C        C  PP              +AN    G      
Sbjct: 871  TIDIDECI-SKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDG 929

Query: 3141 ESEVKLRCLEGYTMDT-DTDTFTCQ----KDGRWFPERISCSPKKCPLPENITHILVHGD 3195
             +     CL G+T D   TD   C     K+G    + ++    KC    +  H      
Sbjct: 930  VNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHC----- 984

Query: 3196 DFSVNRQVSVSCAEGYT-FEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVG 3254
            + ++N     SC  G T  +G+N   C     +   F     +   C        G  V 
Sbjct: 985  ENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEIN--ECSSHPCLNEGTCVD 1042

Query: 3255 SKYTFESTIIYQCEPGYELEGNRERV--CQENRQWSGGVAICK--ETRCETPLEFLNGKA 3310
               T+  +    C  GY  +  +  V  C  +   + G  + K  E++C  P  +     
Sbjct: 1043 GLGTYRCS----CPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYC 1098

Query: 3311 DIENRTTGPNVVYSCNRGYSLEGPSEAH-CTENGTWSHP--VPLCKPNPCPVPFVIPENA 3367
            D+      PNV  SC+   S  G    H C  +G   +      C+   CP+ +      
Sbjct: 1099 DV------PNV--SCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQ---CPLGYTG---- 1143

Query: 3368 LLSEKEFYVDQNVSIKCREGFL------------LQGHGIITCNPDETWTQTSAKCE--- 3412
              S  E  +D+  S  C+ G              + G+  + C  +    Q    C+   
Sbjct: 1144 --SYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQP-CQNGG 1200

Query: 3413 ---------KISCGPPAH----VENA--IARGVHYQYGDMIT-----YSC-----YSGYM 3447
                     K SC P        EN    ARG H   G         YSC     ++G  
Sbjct: 1201 TCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGER 1260

Query: 3448 LEGFLRSVCLENGTWTSPPICRAVCRFPCQNGG---ICQRPN--ACSCPEGWMGRLCEEP 3502
             EG +   CL N               PC + G     Q  N   C C   + GR CE  
Sbjct: 1261 CEGDINE-CLSN---------------PCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETF 1304

Query: 3503 ICI---LPCLNGGRCVAP------YQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRP---N 3550
            + +   +PCLNGG C         + C CPPG++G+RC ++  Q  C  G +CV      
Sbjct: 1305 VDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGP 1364

Query: 3551 RCHCLS 3556
            RC C S
Sbjct: 1365 RCFCPS 1370



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 37/103 (35%), Positives = 49/103 (47%), Gaps = 15/103 (14%)

Query: 3476 CQNGGIC---QRPNACSCPEGWMGRLCEEPI---CILPCLNGGRC---VAPYQCDCPPGW 3526
            CQ+ G+C      + C CP G+ G  CEE +      PC +G  C   +  Y+C+C PG+
Sbjct: 1120 CQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGY 1179

Query: 3527 TGSRCHTAV--CQS-PCLNGGKC---VRPNRCHCLSSWTGHNC 3563
             G  C   V  CQ+ PC NGG C   V   +C C     G  C
Sbjct: 1180 QGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLC 1222



 Score = 63.9 bits (154), Expect = 3e-09
 Identities = 37/116 (31%), Positives = 51/116 (43%), Gaps = 25/116 (21%)

Query: 3473 RFPCQNGGICQRPNA---CSCPEGWMGRLCEEP--ICILP-----------CLNGGRCV- 3515
            R PC+N G C +  A   C CP GW G  C+ P   C +            C + G C+ 
Sbjct: 1069 RSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCIN 1128

Query: 3516 --APYQCDCPPGWTGSRCHTAV---CQSPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
                + C CP G+TGS C   +     +PC +G  C   +   RC C+  + G NC
Sbjct: 1129 AGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNC 1184



 Score = 63.5 bits (153), Expect = 3e-09
 Identities = 39/103 (37%), Positives = 51/103 (49%), Gaps = 14/103 (13%)

Query: 3475 PCQNGGIC-QRPNA--CSCPEGWMGRLCEEPI--CILPCLNGGRC---VAPYQCDCPPGW 3526
            PC NG  C   PN   C C  G+ G LCEE I  C     + G+C   +  Y C C PG+
Sbjct: 540  PCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGY 599

Query: 3527 TGSRCHTAVCQ---SPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
             G+ C   + +   SPCLN G+C   V   +C+C    +G NC
Sbjct: 600  MGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNC 642



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 38/104 (36%), Positives = 47/104 (45%), Gaps = 15/104 (14%)

Query: 3475 PCQNGGICQ---RPNACSCPEGWMGRLCEEPI--CIL-PCLNGGRC---VAPYQCDCPPG 3525
            PCQNGG C       +C C  G+ G  C+  +  C+  PC NGG C   V  Y C C  G
Sbjct: 919  PCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAG 978

Query: 3526 WTGSRCHTAV---CQSPCLNGGKCV---RPNRCHCLSSWTGHNC 3563
            + G  C   +    +S C NGG CV       C C   +TG  C
Sbjct: 979  FDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFC 1022



 Score = 60.5 bits (145), Expect = 3e-08
 Identities = 82/338 (24%), Positives = 127/338 (37%), Gaps = 68/338 (20%)

Query: 3267 CEPGY-----ELEGNRERVCQENRQWSGGVAICKETR--CETPLEFLNG--KADIENRTT 3317
            C PG+     ELE N    CQ N   + G  + K  R  C  P  F     + DI++ ++
Sbjct: 482  CMPGFKGVHCELEINE---CQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSS 538

Query: 3318 GPNVVYSCNRGYSLEGPS--EAHCTENGTW---SHPVPLCKPNPCPVPFVIPENALLSEK 3372
             P +    N    ++ P+  E  C    T       +  C P+PC             + 
Sbjct: 539  TPCL----NGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHH----------GQC 584

Query: 3373 EFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQ---TSAKCEKISCGPPAHVENAIARG 3429
            +  +D    I C  G++     I +   DE ++       +C  +  G   + +   + G
Sbjct: 585  QDGIDSYTCI-CNPGYM---GAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTS-G 639

Query: 3430 VHYQ--YGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRF--------PCQNG 3479
            V+ +  + D  +  C  G  ++G  R  C+      SP      C          PC+ G
Sbjct: 640  VNCEINFDDCASNPCIHGICMDGINRYSCV-----CSPGFTGQRCNIDIDECASNPCRKG 694

Query: 3480 GIC---QRPNACSCPEGWMGRLCEEPI--CIL-PCLNGGRC--VAPYQCDCPPGWTGSRC 3531
              C        C CPEG     C   +  C+  PC++G     ++ Y+C C  GW G  C
Sbjct: 695  ATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINC 754

Query: 3532 H---TAVCQSPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
                     +PC NGG C   V   RC C   + G+NC
Sbjct: 755  EVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNC 792



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 37/105 (35%), Positives = 42/105 (40%), Gaps = 16/105 (15%)

Query: 3476 CQNGGICQRPNA---CSCPEGWMGRLCEEPI---CILPCLNGGRC---VAPYQCDCPPGW 3526
            CQNGG C   N    C C  GW G  C E I       C  G  C   VA + C CP G 
Sbjct: 309  CQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGK 368

Query: 3527 TGSRCH--TAVCQSPCLNGGKC-VRPNR----CHCLSSWTGHNCS 3564
             G  CH   A   +PC  G  C   P      C C   + G +C+
Sbjct: 369  AGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCT 413



 Score = 53.5 bits (127), Expect = 4e-06
 Identities = 62/266 (23%), Positives = 87/266 (32%), Gaps = 75/266 (28%)

Query: 3373 EFYVDQNVSIKCREGFLLQGHGIITC--NPDETWTQTSA---KCEKISCGPPAHVENAI- 3426
            E   D   S  C  G  + G    +C  +P  T  + +    +C    C   A   N + 
Sbjct: 643  EINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVN 702

Query: 3427 ------ARGVHY-----QYGDMITYSCYSGYMLEGFLRSVCLENGTWT--SPPICRAVCR 3473
                    G H+     Q  + ++  C  G    G     CL +  W   +  + +  C 
Sbjct: 703  GFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECL 762

Query: 3474 F-PCQNGGICQR---PNACSCPEGWMGRLCEEPI---CILPCLNGGRC------------ 3514
              PCQNGG C        C+C +G+ G  C+  I      PCLN G C            
Sbjct: 763  SNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCV 822

Query: 3515 -----------VAP--------------------YQCDCPPGWTGSRCHTAV---CQSPC 3540
                       +AP                    Y C C PGW G RC   +      PC
Sbjct: 823  LPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPC 882

Query: 3541 LNGGKCVRPN---RCHCLSSWTGHNC 3563
            +N G C        C C   ++G +C
Sbjct: 883  MNHGLCHNTQGSYMCECPPGFSGMDC 908



 Score = 52.8 bits (125), Expect = 6e-06
 Identities = 26/75 (34%), Positives = 39/75 (52%), Gaps = 4/75 (5%)

Query: 1352 QPCKNGATCKDGANSFR-CLCAAGFTGSHCELNINECQSNPCRNQATCVDE--LNSYSCK 1408
            +PC N   C    N    C C  GF G +C+ + + C+ N C+N  TCV +  L   +C+
Sbjct: 33   EPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCR 91

Query: 1409 CQPGFSGKRCETEQS 1423
            C  GF+G+ C+   S
Sbjct: 92   CASGFTGEDCQYSTS 106



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 59/226 (26%), Positives = 81/226 (35%), Gaps = 47/226 (20%)

Query: 1730 CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKC 1789
            C     W G     +D+DEC +   C  H  C N  GSY+C C P ++  G +C E I  
Sbjct: 859  CLCAPGWQG-QRCTIDIDEC-ISKPCMNHGLCHNTQGSYMCECPPGFS--GMDCEEDIDD 914

Query: 1790 KAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLI---------- 1839
                  +NG S      +    TFSC     L G T   C    + N  +          
Sbjct: 915  CLANPCQNGGS-----CMDGVNTFSC---LCLPGFTGDKC--QTDMNECLSEPCKNGGTC 964

Query: 1840 -PYCKAVSCGKPAIPE--------NGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLAN 1890
              Y  + +C   A  +        N C E   F          N G  + G    SCL  
Sbjct: 965  SDYVNSYTCKCQAGFDGVHCENNINECTESSCF----------NGGTCVDGINSFSCLCP 1014

Query: 1891 SSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYS 1936
              ++ S  + E  +CSS   +N G  +      L T   SC  GY+
Sbjct: 1015 VGFTGSFCLHEINECSSHPCLNEGTCV----DGLGTYRCSCPLGYT 1056



 Score = 42.4 bits (98), Expect = 0.008
 Identities = 41/182 (22%), Positives = 70/182 (38%), Gaps = 34/182 (18%)

Query: 252 FEALARRALHEDLP-SGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKG 310
           F+ ++    H  LP +G   Q  +  CS       + C+    CK   +   + C+C  G
Sbjct: 811 FDDISGYTCHCVLPYTGKNCQTVLAPCS------PNPCENAAVCKESPNFESYTCLCAPG 864

Query: 311 YYGKGLQYECTACPS-------------GTYKPEGSPG--------GISSCIPCPDENHT 349
           + G+    +   C S             G+Y  E  PG         I  C+  P +N  
Sbjct: 865 WQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGG 924

Query: 350 SPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPG 409
           S     +   C+C  G+       ++  C + +P +NG     TC+++ N+    +C  G
Sbjct: 925 SCMDGVNTFSCLCLPGFTGDKCQTDMNECLS-EPCKNG----GTCSDYVNSYT-CKCQAG 978

Query: 410 FD 411
           FD
Sbjct: 979 FD 980



 Score = 41.6 bits (96), Expect = 0.014
 Identities = 42/139 (30%), Positives = 55/139 (39%), Gaps = 30/139 (21%)

Query: 280  LCDEGKDCCDRMGSC----KCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPG 335
            LC+E  D C R   C    +C    G + C C  G+ G+  + +   C S     EGS  
Sbjct: 1221 LCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGS-- 1278

Query: 336  GISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCE--LVHCPALKPPENGYFIQNT 393
                CI             T+   CVCR  +  +G+ CE  +  CP + P  NG     T
Sbjct: 1279 --LDCIQL-----------TNDYLCVCRSAF--TGRHCETFVDVCPQM-PCLNG----GT 1318

Query: 394  CNNHFNAACG--VRCHPGF 410
            C    N   G   RC PGF
Sbjct: 1319 CAVASNMPDGFICRCPPGF 1337



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 29/108 (26%), Positives = 43/108 (39%), Gaps = 8/108 (7%)

Query: 1672 CLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMF-C 1730
            CLN G            +C V      GF   +  +  + +++ C NG      +  F C
Sbjct: 115  CLNGGTCHMLSRDTYECTCQV------GFTGKECQWTDACLSHPCANGSTCTTVANQFSC 168

Query: 1731 TDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778
                 + G      DV+EC +   C    +CLN+ GSY C C   +TG
Sbjct: 169  KCLTGFTGQKCET-DVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTG 215



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 43/198 (21%), Positives = 67/198 (33%), Gaps = 62/198 (31%)

Query: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGD----------------GKNCAEPIK 1788
            D+D+C + + C    SC++   ++ C C+P +TGD                G  C++ + 
Sbjct: 911  DIDDC-LANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVN 969

Query: 1789 ---CKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCL-----ESGEWNHLIP 1840
               CK     +  H    I        F+   G  + G+   +CL           H I 
Sbjct: 970  SYTCKCQAGFDGVHCENNINECTESSCFN--GGTCVDGINSFSCLCPVGFTGSFCLHEIN 1027

Query: 1841 YCKAVSCGKPAIPENGCIEELAFTFGSKVTYRC------------------------NKG 1876
             C +     P + E  C++ L        TYRC                        NKG
Sbjct: 1028 ECSS----HPCLNEGTCVDGLG-------TYRCSCPLGYTGKNCQTLVNLCSRSPCKNKG 1076

Query: 1877 YTLAGDKESSCLANSSWS 1894
              +    ES CL  S W+
Sbjct: 1077 TCVQKKAESQCLCPSGWA 1094



 Score = 39.7 bits (91), Expect = 0.054
 Identities = 23/68 (33%), Positives = 33/68 (48%), Gaps = 4/68 (5%)

Query: 1730 CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKC 1789
            CT    + G +   +++DECA  + C    +C +    Y C CV PYT  GKNC   +  
Sbjct: 781  CTCKKGFKGYNCQ-VNIDECA-SNPCLNQGTCFDDISGYTCHCVLPYT--GKNCQTVLAP 836

Query: 1790 KAPGNPEN 1797
             +P   EN
Sbjct: 837  CSPNPCEN 844



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 15/36 (41%), Positives = 21/36 (58%), Gaps = 2/36 (5%)

Query: 1745 DVDECAVGSD--CSEHASCLNVDGSYICSCVPPYTG 1778
            DVDECA+ +   C     C+N DG++ C C+  Y G
Sbjct: 415  DVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAG 450



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 32/118 (27%), Positives = 42/118 (35%), Gaps = 26/118 (22%)

Query: 1672 CLNQGQWTQPLPHCERISCGVPPPLENGF------HSADDFYAGSTVTYQCNNGYYLLGD 1725
            CL    W         +SC +              HS     AG+T   QC  GY     
Sbjct: 1087 CLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGY----- 1141

Query: 1726 SRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNC 1783
            +  +C +             +DECA  + C   A+C +  G Y C CVP Y   G NC
Sbjct: 1142 TGSYCEEQ------------LDECA-SNPCQHGATCSDFIGGYRCECVPGY--QGVNC 1184



 Score = 37.7 bits (86), Expect = 0.21
 Identities = 26/77 (33%), Positives = 38/77 (49%), Gaps = 7/77 (9%)

Query: 1714 YQCNNGYYLL-GDSRMFCTDNGSWNGVSPSCL-DVDECAVGSD-CSEHASCLNVDGSYIC 1770
            ++C NG   + G +   C     W G    C  DVDEC +  + C    +C N +G Y C
Sbjct: 267  HRCQNGGVCVDGVNTYNCRCPPQWTG--QFCTEDVDECLLQPNACQNGGTCANRNGGYGC 324

Query: 1771 SCVPPYTGDGKNCAEPI 1787
             CV  ++GD  +C+E I
Sbjct: 325  VCVNGWSGD--DCSENI 339



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 35/161 (21%), Positives = 53/161 (32%), Gaps = 40/161 (24%)

Query: 267 GSFIQDDMVHCSYLCD-----EGKDCCDRMGSC------------KCGTHTGHFECICEK 309
           G+    + ++  Y+C      +G DC + +  C            KC    G F C C K
Sbjct: 387 GALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLK 446

Query: 310 GYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRAS 369
           GY G   + +   C S                PC  +N  +         C+C  G++  
Sbjct: 447 GYAGPRCEMDINECHSD---------------PC--QNDATCLDKIGGFTCLCMPGFKGV 489

Query: 370 GQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGF 410
               E+  C +     NG  +     N F       C PGF
Sbjct: 490 HCELEINECQSNPCVNNGQCVDKV--NRFQCL----CPPGF 524



 Score = 36.2 bits (82), Expect = 0.60
 Identities = 44/183 (24%), Positives = 61/183 (33%), Gaps = 31/183 (16%)

Query: 296 CGTHTGHFECICEKGYYGKGLQYECTACPS------GT---------------YKPEGSP 334
           C      + C C+KG+ G   Q     C S      GT               Y  +   
Sbjct: 772 CDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQ 831

Query: 335 GGISSCIPCPDENHTSPPGSTSPED--CVCREGYRASGQTCELVHCPALKPPENGYFIQN 392
             ++ C P P EN      S + E   C+C  G++    T ++  C + KP  N     N
Sbjct: 832 TVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECIS-KPCMNHGLCHN 890

Query: 393 TCNNHFNAACGVRCHPGFDLVG--SSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHIS 450
           T  ++        C PGF  +     I  CL N   +G      V T   L  P      
Sbjct: 891 TQGSYM-----CECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDK 945

Query: 451 CST 453
           C T
Sbjct: 946 CQT 948



 Score = 36.2 bits (82), Expect = 0.60
 Identities = 35/148 (23%), Positives = 59/148 (39%), Gaps = 29/148 (19%)

Query: 273  DMVHCSYLCDE-GKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPS------ 325
            D VHC    +E  +  C   G+C  G ++  F C+C  G+ G    +E   C S      
Sbjct: 980  DGVHCENNINECTESSCFNGGTCVDGINS--FSCLCPVGFTGSFCLHEINECSSHPCLNE 1037

Query: 326  -------GTYK---PEGSPGG-----ISSCIPCPDENHTSPPGSTSPEDCVCREGYRASG 370
                   GTY+   P G  G      ++ C   P +N  +     +   C+C  G+  +G
Sbjct: 1038 GTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGW--AG 1095

Query: 371  QTCEL--VHCPALKPPENGYFIQNTCNN 396
              C++  V C  +     G  +++ C +
Sbjct: 1096 AYCDVPNVSCD-IAASRRGVLVEHLCQH 1122



 Score = 36.2 bits (82), Expect = 0.60
 Identities = 12/35 (34%), Positives = 20/35 (57%)

Query: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGD 1779
            ++D+CA G  C     C++  G Y C C+P + G+
Sbjct: 1225 NIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGE 1259



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 59/243 (24%), Positives = 84/243 (34%), Gaps = 59/243 (24%)

Query: 276 HCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPG 335
           +C +     K+ C   G+C      G   C C  G+ G+  QY  T+ P    +P     
Sbjct: 61  YCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYS-TSHPCFVSRP----- 114

Query: 336 GISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCN 395
               C+       T    S    +C C+ G+  +G+ C+        P  NG    +TC 
Sbjct: 115 ----CL----NGGTCHMLSRDTYECTCQVGF--TGKECQWTDACLSHPCANG----STCT 160

Query: 396 ---NHFNAAC-----GVRCH--------PG--------FDLVGSSIILCLPNGLWSGSES 431
              N F+  C     G +C         PG         +L GS    C P G    +  
Sbjct: 161 TVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQC-PQGF---TGQ 216

Query: 432 YCRVRTCPHLRQP-KHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPE 490
           YC     P    P  +G     T +  ++  CL         EGS   TC+ N   D P 
Sbjct: 217 YCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPG------FEGS---TCERNID-DCPN 266

Query: 491 PRC 493
            RC
Sbjct: 267 HRC 269



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 44/176 (25%), Positives = 60/176 (34%), Gaps = 41/176 (23%)

Query: 266 SGSFIQDDMVHCSYL-CDEGKDCCDRMGSCKCGTHTG------HFECICEKGYYGKGL-- 316
           SG    +++  C++  C  G  C DR+ S  C    G      H +  C      KG   
Sbjct: 331 SGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALC 390

Query: 317 -------QYECTACPSGTYKPEGSPGGISSCIPC---PDENHTSPPGSTSPEDCVCREGY 366
                  QY CT CP G YK       +  C      P E+      +     C C +GY
Sbjct: 391 DTNPLNGQYICT-CPQG-YKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGY 448

Query: 367 RASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLP 422
             +G  CE+        P         C N  +A C        D +G    LC+P
Sbjct: 449 --AGPRCEMDINECHSDP---------CQN--DATC-------LDKIGGFTCLCMP 484



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 43/180 (23%), Positives = 64/180 (35%), Gaps = 27/180 (15%)

Query: 1717 NNGYYLLGDSRMFCTDNGSWNGVSPSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPP 1775
            NNG  +   +R  C     + G  P C +D+D+C+  + C   A C++    Y C C   
Sbjct: 505  NNGQCVDKVNRFQCLCPPGFTG--PVCQIDIDDCS-STPCLNGAKCIDHPNGYECQCATG 561

Query: 1776 YTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGY-------QLMGVTKIT 1828
            +T  G  C E I    P    +G     I       T  C  GY       Q+       
Sbjct: 562  FT--GVLCEENIDNCDPDPCHHGQCQDGI----DSYTCICNPGYMGAICSDQIDECYSSP 615

Query: 1829 CLESGEWNHLI--------PYCKAVSC--GKPAIPENGCIEELAFTFGSKVTYRCNKGYT 1878
            CL  G    L+        P    V+C         N CI  +     ++ +  C+ G+T
Sbjct: 616  CLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFT 675



 Score = 33.1 bits (74), Expect = 5.1
 Identities = 19/76 (25%), Positives = 32/76 (42%), Gaps = 4/76 (5%)

Query: 1746 VDECAVGSDCSEHASCLN--VDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGE 1803
            +D+  + + C + A C    ++G YIC+C   Y   G +C E +   A  N      +G+
Sbjct: 375  LDDACISNPCHKGALCDTNPLNGQYICTCPQGY--KGADCTEDVDECAMANSNPCEHAGK 432

Query: 1804 IYTVGAEVTFSCQEGY 1819
                       C +GY
Sbjct: 433  CVNTDGAFHCECLKGY 448



 Score = 33.1 bits (74), Expect = 5.1
 Identities = 14/39 (35%), Positives = 22/39 (56%), Gaps = 2/39 (5%)

Query: 1741 PSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778
            P C +D++EC     C   A+CL+  G + C C+P + G
Sbjct: 451  PRCEMDINECH-SDPCQNDATCLDKIGGFTCLCMPGFKG 488



 Score = 32.3 bits (72), Expect = 8.6
 Identities = 47/191 (24%), Positives = 59/191 (30%), Gaps = 46/191 (24%)

Query: 230 ELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYL-CDEGKDCC 288
           E+N+  S P   +   +     F+ L          +G   Q D+  CS   C  G  C 
Sbjct: 494 EINECQSNPCVNNGQCVDKVNRFQCLCPPGF-----TGPVCQIDIDDCSSTPCLNGAKCI 548

Query: 289 DRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENH 348
           D         H   +EC C  G+ G         C             I +C P P  + 
Sbjct: 549 D---------HPNGYECQCATGFTG-------VLCEE----------NIDNCDPDPCHHG 582

Query: 349 TSPPGSTSPEDCVCREGYR---ASGQTCELVHCPALKPPE-----NGYFIQNTCNNHFNA 400
               G  S   C+C  GY     S Q  E    P L         NGY  Q  C      
Sbjct: 583 QCQDGIDS-YTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGY--QCNCQ---PG 636

Query: 401 ACGVRCHPGFD 411
             GV C   FD
Sbjct: 637 TSGVNCEINFD 647


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  265 bits (678), Expect = 5e-70
 Identities = 153/452 (33%), Positives = 223/452 (49%), Gaps = 35/452 (7%)

Query: 996  GRMCVNCPLGTYYNLEHFTCESCRIG-------SYQDEEGQLECKLCPSGMYTEYIHSRN 1048
            GR   +CP G          + CR+G       +  +  G   C+ CP+G       +  
Sbjct: 140  GRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQ-CPAGYTGPLCENPA 198

Query: 1049 ISDCKAQCKQG-TYSYSGLETCESCPLGTYQPKFGSRSCLSCPE----NTSTVKRGAVNI 1103
            +    + C+ G T   SG  T +   L  ++ +    +   CP     N  T   G VN 
Sbjct: 199  VPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDG-VNT 257

Query: 1104 SACGVPCPE--GKFSRSGLMPCHPCPRDYYQPNAGKAF-------CLACPFYGTTPFAGS 1154
              C  P PE  G+F    +  C   P   +  N G  F       C+     G T  + S
Sbjct: 258  YNCQCP-PEWTGQFCTEDVDECQLQPNACH--NGGTCFNTLGGHSCVCVN--GWTGESCS 312

Query: 1155 RSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQL--- 1211
            ++I +C++      A     V          +  +   +   C  NPCH    C      
Sbjct: 313  QNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVN 372

Query: 1212 GRGYVCLCPLGYTGLKCETDIDECS--PLPCLNNGVCKDLVGEFICECPSGYTGQRCEEN 1269
            GR  +C CP G+TG  C+ D+DECS    PC + G C +  G F+C+C  GYTG RCE +
Sbjct: 373  GRA-ICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETD 431

Query: 1270 INECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGF 1329
            +NEC S PC N+  C+D +  + C C+ GF G +CE +++ECQS+PC+N  VC+D+V GF
Sbjct: 432  VNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGF 491

Query: 1330 LCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQS 1389
             C CP GF G+ C  +VDEC S PC+NGA C D  + + C CA GF G+ C+ N+++C  
Sbjct: 492  SCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSP 551

Query: 1390 NPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
            +PC +   CVD + S+SC C PG++G RCE++
Sbjct: 552  DPC-HHGRCVDGIASFSCACAPGYTGTRCESQ 582



 Score =  264 bits (674), Expect = 1e-69
 Identities = 175/515 (33%), Positives = 230/515 (44%), Gaps = 100/515 (19%)

Query: 988  CRPGSVLR-GRMCVN--------CPLGTYYNLEHFTCES---------CRIGSYQDEEGQ 1029
            CR G   R G  C+N        CP G    L    CE+         CR G    + G 
Sbjct: 162  CRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPL----CENPAVPCAPSPCRNGGTCRQSGD 217

Query: 1030 L--ECKLCPS--GMYTEYIHSRNISDCKAQ-------CKQGTYSYSG-----------LE 1067
            L  +C   P   G   E     N+ DC          C  G  +Y+             E
Sbjct: 218  LTYDCACLPGFEGQNCEV----NVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTE 273

Query: 1068 TCESCPL--------GTYQPKFGSRSCL--------SCPEN-----TSTVKRGAV---NI 1103
              + C L        GT     G  SC+        SC +N     T+    GA     +
Sbjct: 274  DVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRV 333

Query: 1104 SACGVPCPEGKFSRSGLMPCH--------PCPRDYY---QPNAGKAFCLACPFYGTTPFA 1152
            ++    CP GK   +GL+ CH        PC  D      P  G+A C   P  G T  A
Sbjct: 334  ASFYCACPMGK---TGLL-CHLDDACVSNPCHEDAICDTNPVNGRAICTCPP--GFTGGA 387

Query: 1153 GSRSITECSSFSSTFSAAEESVVPPASL------GHIKKRHEISSQVFHECFFNPCHNSG 1206
              + + ECS  ++        V    S       G+   R E      +EC   PC N  
Sbjct: 388  CDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETD---VNECLSGPCRNQA 444

Query: 1207 TCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRC 1266
            TC      + C+C  G+TG  CE DIDEC   PC+N GVCKD V  F C CPSG++G  C
Sbjct: 445  TCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTC 504

Query: 1267 EENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQV 1326
            + +++EC+S+PC N   CVD   GY C C +GF G  C+  V++C  +PC ++  C D +
Sbjct: 505  QLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPC-HHGRCVDGI 563

Query: 1327 GGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINE 1386
              F C C PG+ GTRC   VDEC SQPC++G  C D  + + C C +G TG +CE+NI++
Sbjct: 564  ASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDD 623

Query: 1387 CQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
            C SNPC     C D +N Y C CQPGF+G  C  E
Sbjct: 624  CASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVE 657



 Score =  214 bits (544), Expect = 2e-54
 Identities = 95/226 (42%), Positives = 127/226 (56%), Gaps = 5/226 (2%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            +C  +PCH+ G C      + C C  GYTG +CE+ +DEC   PC + G C DLV +++C
Sbjct: 548  DCSPDPCHH-GRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLC 606

Query: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP 1315
             CPSG TG  CE NI++C+S+PC   G+C DG+  Y C C  GF G  C  E+NEC S+P
Sbjct: 607  RCPSGTTGVNCEVNIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSP 665

Query: 1316 CLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGF 1375
            C     C D   GF C CPPG L   C      C  +PC +G  C D    FRC+C  G+
Sbjct: 666  CGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPGGFRCVCEPGW 724

Query: 1376 TGSHCELNI--NECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
            +G  C  ++  + C+S PCR   TC  +   + C C PG  G++CE
Sbjct: 725  SGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCE 770



 Score =  208 bits (529), Expect = 9e-53
 Identities = 136/456 (29%), Positives = 181/456 (39%), Gaps = 85/456 (18%)

Query: 1016 ESCRIGSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQ-CKQGTYSYSGLETCESCPL 1074
            E C  G   D  G   C   P         S     C++Q C+ G        TC S  +
Sbjct: 702  EPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGG-------TCSSDGM 754

Query: 1075 GTYQPKFGSRSCLSCPENTSTVKRGAVNISACGV-PCPEGKFSRS--GLMPCHPCPRDYY 1131
            G +          +CP       R    +S C   PC  G    S  G +P   CP+ + 
Sbjct: 755  GFH---------CTCPPGVQG--RQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQ 803

Query: 1132 QPNAGKAFCLACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISS 1191
             P   +         G  P  G   I  C++ + +FS          S            
Sbjct: 804  GPRCQQDVDECA---GPAP-CGPHGI--CTNLAGSFSCTCHGGYTGPSC----------D 847

Query: 1192 QVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVG 1251
            Q  ++C  NPC N G+CQ     + C C  G+ G +C  D+DEC   PC   G C D V 
Sbjct: 848  QDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC-GPGTCTDHVA 906

Query: 1252 EFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNEC 1311
             F C CP GY G  CE+++ +CS S C N G CVDGV  + C C  G+ G HC+ E + C
Sbjct: 907  SFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPC 966

Query: 1312 QSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKN--------------- 1356
             S PCL+  VC     GF C C   F G +C   VD C  QPC+N               
Sbjct: 967  LSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPP 1026

Query: 1357 -------------------------------GATCKDGANSFRCLCAAGFTGSHCELNIN 1385
                                           G  C D  +S  C+C  G TGSHCE  ++
Sbjct: 1027 GWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVD 1086

Query: 1386 ECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
             C + PC++  TC   +  Y C+C PG++G  CE +
Sbjct: 1087 PCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDD 1122



 Score =  204 bits (520), Expect = 1e-51
 Identities = 139/467 (29%), Positives = 185/467 (39%), Gaps = 90/467 (19%)

Query: 1009 NLEHFTCES--CRIGSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQ-CKQGTYSYSG 1065
            +L    CES  CR G     +G      CP G+         +S C    C+ G      
Sbjct: 732  SLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL--LSPCTPNPCEHGG----- 784

Query: 1066 LETCESCPLGTYQPKFGSRSCLSCPENTSTVKRGAVNISACGVPCPEGKF----SRSGLM 1121
               CES P        G     SCP+      R   ++  C  P P G      + +G  
Sbjct: 785  --RCESAP--------GQLPVCSCPQGWQG-PRCQQDVDECAGPAPCGPHGICTNLAGSF 833

Query: 1122 PCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLG 1181
             C  C   Y  P+  +      P     P     S   C     +FS    S +P    G
Sbjct: 834  SC-TCHGGYTGPSCDQDINDCDP----NPCLNGGS---CQDGVGSFSC---SCLP----G 878

Query: 1182 HIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCL 1241
                R    ++   EC  NPC   GTC      + C CP GY G  CE D+ +CSP  C 
Sbjct: 879  FAGPR---CARDVDECLSNPC-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCF 934

Query: 1242 NNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVG 1301
            N G C D V  F C C  GYTG  C+   + C S PCL+ G+C     G+RCTC++ F G
Sbjct: 935  NGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTG 994

Query: 1302 LHCETEVNECQSNPCLNNAVCED------------------------------------- 1324
              C+T V+ C   PC N   C                                       
Sbjct: 995  PQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQL 1054

Query: 1325 -QVGG--------FLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGF 1375
             Q GG          C CP G  G+ C + VD CL+QPC++G TC+     + C C  G+
Sbjct: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY 1114

Query: 1376 TGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQ 1422
             G +CE +++EC S PC++  +C+D +  Y C C PG  G  CE  +
Sbjct: 1115 NGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINE 1161



 Score =  203 bits (516), Expect = 3e-51
 Identities = 90/233 (38%), Positives = 127/233 (54%), Gaps = 15/233 (6%)

Query: 1202 CHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGY 1261
            C   G C      + C+CP G TG  CE ++D C   PC + G C+  +G ++CEC  GY
Sbjct: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY 1114

Query: 1262 TGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP------ 1315
             G  CE++++EC+S PC + G C+D VA Y C+C  G +G+ CE   ++C   P      
Sbjct: 1115 NGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGP 1174

Query: 1316 -CLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGAT---CKDGANSFRCLC 1371
             CL+N  C D VGGF C CPPG+ G RC  +++EC S  C    T    +D    FRCLC
Sbjct: 1175 RCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLC 1234

Query: 1372 AAGFTGSHCELNINECQSNPCRNQATCVDELN-----SYSCKCQPGFSGKRCE 1419
             AGF+G  C+  ++ C+S PC++   C          +++C C   F G RCE
Sbjct: 1235 HAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCE 1287



 Score =  200 bits (508), Expect = 2e-50
 Identities = 96/239 (40%), Positives = 121/239 (50%), Gaps = 15/239 (6%)

Query: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICE 1256
            C   PC + GTC+    GY+C C  GY G  CE D+DEC+  PC + G C DLV  ++C 
Sbjct: 1088 CLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCS 1147

Query: 1257 CPSGYTGQRCEENINECSSSP-------CLNKGICVDGVAGYRCTCVKGFVGLHCETEVN 1309
            CP G  G  CE N ++C   P       CL+ G CVD V G+RCTC  G+ GL CE ++N
Sbjct: 1148 CPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADIN 1207

Query: 1310 ECQSNPC--LNNAVC-EDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCK----- 1361
            EC+S  C   +   C +D  GGF C C  GF G RC   +  C SQPC++G  C+     
Sbjct: 1208 ECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGP 1267

Query: 1362 DGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCET 1420
             G  +F C CA  F G  CE     C+   C     C        C C PG SG  C +
Sbjct: 1268 GGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRS 1326



 Score =  198 bits (504), Expect = 7e-50
 Identities = 92/232 (39%), Positives = 125/232 (53%), Gaps = 5/232 (2%)

Query: 1197 CFFNPCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSP-LPCLNNGVCKDLVGEFI 1254
            C  +PC +   C     G ++C CP GY G  C +D+DEC    PC + G C +  G F 
Sbjct: 123  CLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFR 182

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGIC-VDGVAGYRCTCVKGFVGLHCETEVNECQS 1313
            C+CP+GYTG  CE     C+ SPC N G C   G   Y C C+ GF G +CE  V++C  
Sbjct: 183  CQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPG 242

Query: 1314 NPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQP--CKNGATCKDGANSFRCLC 1371
            + CLN   C D V  + C+CPP + G  C ++VDEC  QP  C NG TC +      C+C
Sbjct: 243  HRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVC 302

Query: 1372 AAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQS 1423
              G+TG  C  NI++C +  C + ATC D + S+ C C  G +G  C  + +
Sbjct: 303  VNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDA 354



 Score =  197 bits (502), Expect = 1e-49
 Identities = 128/434 (29%), Positives = 189/434 (43%), Gaps = 18/434 (4%)

Query: 998  MCVNCPLGTYYNLEHFTCESCRI---GSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKA 1054
            +C+    GTY  ++   C+S      G  +D      C  CPSG ++      ++ +C +
Sbjct: 456  ICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCT-CPSG-FSGSTCQLDVDECAS 513

Query: 1055 Q-CKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSC---PENTSTVKRGAVNISACGVPC 1110
              C+ G       +  E      ++     R+   C   P +      G  + S    P 
Sbjct: 514  TPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPG 573

Query: 1111 PEGKFSRSGLMPCH--PCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITECSSFSSTFS 1168
              G    S +  C   PC       +    +   CP  GTT      +I +C+S   TF 
Sbjct: 574  YTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPS-GTTGVNCEVNIDDCASNPCTFG 632

Query: 1169 AAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKC 1228
               + +     +        + +   +EC  +PC   G+C     G+ CLCP G     C
Sbjct: 633  VCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLC 692

Query: 1229 ETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENI--NECSSSPCLNKGICVD 1286
                  C+  PC ++G+C D  G F C C  G++G RC +++  + C S PC   G C  
Sbjct: 693  LPPSHPCAHEPC-SHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSS 751

Query: 1287 GVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGF-LCKCPPGFLGTRCGKN 1345
               G+ CTC  G  G  CE  ++ C  NPC +   CE   G   +C CP G+ G RC ++
Sbjct: 752  DGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQD 810

Query: 1346 VDECLS-QPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNS 1404
            VDEC    PC     C + A SF C C  G+TG  C+ +IN+C  NPC N  +C D + S
Sbjct: 811  VDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGS 870

Query: 1405 YSCKCQPGFSGKRC 1418
            +SC C PGF+G RC
Sbjct: 871  FSCSCLPGFAGPRC 884



 Score =  185 bits (469), Expect = 8e-46
 Identities = 87/227 (38%), Positives = 124/227 (54%), Gaps = 10/227 (4%)

Query: 1200 NPCHNSGTCQQL-GRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLV----GEFI 1254
            +PC N G C QL  R   CLCP G+ G +C+ + D C   PC   GVC+  V      F 
Sbjct: 47   SPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAGTARFS 105

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAG-YRCTCVKGFVGLHCETEVNECQ- 1312
            C CP G+ G  C    + C SSPC +   C  G  G + C+C  G+ G  C ++V+EC+ 
Sbjct: 106  CRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRV 164

Query: 1313 SNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCK-DGANSFRCLC 1371
              PC +   C +  G F C+CP G+ G  C      C   PC+NG TC+  G  ++ C C
Sbjct: 165  GEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCAC 224

Query: 1372 AAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
              GF G +CE+N+++C  + C N  TCVD +N+Y+C+C P ++G+ C
Sbjct: 225  LPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFC 271



 Score =  170 bits (431), Expect = 2e-41
 Identities = 89/249 (35%), Positives = 114/249 (45%), Gaps = 25/249 (10%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLP-------CLNNGVCKD 1248
            EC   PC + G+C  L   Y+C CP G  G+ CE + D+C P P       CL+NG C D
Sbjct: 1125 ECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVD 1184

Query: 1249 LVGEFICECPSGYTGQRCEENINECSSSPC---LNKGICVDGVAGYRCTCVKGFVGLHCE 1305
            LVG F C CP GYTG RCE +INEC S  C     +    D   G+RC C  GF G  C+
Sbjct: 1185 LVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQ 1244

Query: 1306 TEVNECQSNPCLNNAVCEDQVG-----GFLCKCPPGFLGTRCGKNVDECLSQPCKNGATC 1360
            T ++ C+S PC +   C    G      F C C   F G RC +    C    C  G  C
Sbjct: 1245 TVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPC 1304

Query: 1361 KDGANSFRCLCAAGFTGSHCE--------LNINECQSNPCRNQATC--VDELNSYSCKCQ 1410
            +      RC C  G +G  C          +   C + PC +  +C        + C C 
Sbjct: 1305 QQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACA 1364

Query: 1411 PGFSGKRCE 1419
             G++G RCE
Sbjct: 1365 QGWTGPRCE 1373



 Score =  162 bits (411), Expect = 4e-39
 Identities = 81/189 (42%), Positives = 104/189 (55%), Gaps = 10/189 (5%)

Query: 1239 PCLNNGVCKDLVG-EFICECPSGYTGQRCEENINECSSSPCLNKGIC----VDGVAGYRC 1293
            PC N G C  L   E  C CP G+ G+RC+   + C S PC  +G+C    V G A + C
Sbjct: 48   PCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAGTARFSC 106

Query: 1294 TCVKGFVGLHCETEVNECQSNPCLNNAVCE-DQVGGFLCKCPPGFLGTRCGKNVDEC-LS 1351
             C +GF G  C    + C S+PC + A C     G FLC CPPG+ G  C  +VDEC + 
Sbjct: 107  RCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG 165

Query: 1352 QPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELN-SYSCKCQ 1410
            +PC++G TC +   SFRC C AG+TG  CE     C  +PCRN  TC    + +Y C C 
Sbjct: 166  EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACL 225

Query: 1411 PGFSGKRCE 1419
            PGF G+ CE
Sbjct: 226  PGFEGQNCE 234



 Score =  113 bits (283), Expect = 3e-24
 Identities = 58/151 (38%), Positives = 78/151 (51%), Gaps = 9/151 (5%)

Query: 1276 SPCLNKGICVDGVAGYR-CTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQV----GGFL 1330
            SPC N G C    +    C C  G+VG  C+ E + C S PC    VC+  V      F 
Sbjct: 47   SPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAGTARFS 105

Query: 1331 CKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANS-FRCLCAAGFTGSHCELNINECQ- 1388
            C+CP GF G  C    D CLS PC +GA C  G +  F C C  G+ G  C  +++EC+ 
Sbjct: 106  CRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRV 164

Query: 1389 SNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
              PCR+  TC++   S+ C+C  G++G  CE
Sbjct: 165  GEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE 195



 Score = 80.5 bits (197), Expect = 3e-14
 Identities = 44/109 (40%), Positives = 57/109 (52%), Gaps = 18/109 (16%)

Query: 3475 PCQNGGICQRPNA----CSCPEGWMGRLCEEPICILP---CLNGGRCVA---PYQCDCPP 3524
            PC+NGG C++       C+C  G+ G+ CE  +   P   CLNGG CV     Y C CPP
Sbjct: 205  PCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPP 264

Query: 3525 GWTGSRCHTAV--CQ---SPCLNGGKCVRP---NRCHCLSSWTGHNCSR 3565
             WTG  C   V  CQ   + C NGG C      + C C++ WTG +CS+
Sbjct: 265  EWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQ 313



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 53/140 (37%), Positives = 64/140 (45%), Gaps = 34/140 (24%)

Query: 3453 RSVCLENGTWTSPPICRAVC----RFPCQNGGICQRPNA-CSCPEGWMGRLCEEPICILP 3507
            R  CLE+ T    P C+ +     R PCQNGG C +  A C CP GW GRLC+  I  LP
Sbjct: 985  RCTCLESFTG---PQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCD--IRSLP 1039

Query: 3508 CLN---------------GGRCV---APYQCDCPPGWTGSRCHTAV---CQSPCLNGGKC 3546
            C                 GG+CV   + + C CP G TGS C   V      PC +GG C
Sbjct: 1040 CREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTC 1099

Query: 3547 ---VRPNRCHCLSSWTGHNC 3563
               +    C CL  + G NC
Sbjct: 1100 RGYMGGYMCECLPGYNGDNC 1119



 Score = 77.8 bits (190), Expect = 2e-13
 Identities = 109/437 (24%), Positives = 160/437 (36%), Gaps = 83/437 (18%)

Query: 3147 RCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVS 3206
            RCL G T     +T+ CQ    W  +  +    +C L  N  H    G  F+     S  
Sbjct: 244  RCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHN--GGTCFNTLGGHSCV 301

Query: 3207 CAEGYTFEGV--NISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTII 3264
            C  G+T E    NI  C     +      +  +   C  P   + G +    +  ++ + 
Sbjct: 302  CVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMG-KTGLLC---HLDDACVS 357

Query: 3265 YQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKAD--IENRTTGPNVV 3322
              C        + + +C  N     G AIC       P  F  G  D  ++  + G N  
Sbjct: 358  NPC--------HEDAICDTNPV--NGRAICT-----CPPGFTGGACDQDVDECSIGANPC 402

Query: 3323 YSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSI 3382
                R  + +G     C    T     P C+ +                    V++ +S 
Sbjct: 403  EHLGRCVNTQGSFLCQCGRGYTG----PRCETD--------------------VNECLSG 438

Query: 3383 KCR-EGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMIT-Y 3440
             CR +   L   G  TC     +T T  + +   C     V   + +       D +  +
Sbjct: 439  PCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCK-------DRVNGF 491

Query: 3441 SCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGIC-QRPNA--CSCPEGWMGR 3497
            SC       GF  S C           C +    PC+NG  C  +P+   C C EG+ G 
Sbjct: 492  SCTCP---SGFSGSTCQ-----LDVDECAST---PCRNGAKCVDQPDGYECRCAEGFEGT 540

Query: 3498 LCEEPI--CILPCLNGGRCV---APYQCDCPPGWTGSRCHTAV--CQS-PCLNGGKC--- 3546
            LC+  +  C     + GRCV   A + C C PG+TG+RC + V  C+S PC +GGKC   
Sbjct: 541  LCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDL 600

Query: 3547 VRPNRCHCLSSWTGHNC 3563
            V    C C S  TG NC
Sbjct: 601  VDKYLCRCPSGTTGVNC 617



 Score = 77.0 bits (188), Expect = 3e-13
 Identities = 43/106 (40%), Positives = 49/106 (46%), Gaps = 16/106 (15%)

Query: 3475 PCQNGGIC-QRPNA--CSCPEGWMGRLCEE---PICILPCLNGGRC----VAPYQCDCPP 3524
            PC++GG C   P +  C CP G+ G LCE    P    PC NGG C       Y C C P
Sbjct: 167  PCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLP 226

Query: 3525 GWTGSRCHTAVCQSP---CLNGGKC---VRPNRCHCLSSWTGHNCS 3564
            G+ G  C   V   P   CLNGG C   V    C C   WTG  C+
Sbjct: 227  GFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT 272



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 51/141 (36%), Positives = 63/141 (44%), Gaps = 23/141 (16%)

Query: 3446 YMLEGFLRSVCLENGTWTSPPICRAVCRF-----PCQNGGICQRPNA---CSCPEGWMGR 3497
            Y   G  R VC E G W+ P   +++ R      PC+ GG C        C+CP G  GR
Sbjct: 710  YDAPGGFRCVC-EPG-WSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGR 767

Query: 3498 LCE--EPICILPCLNGGRC-VAPYQ---CDCPPGWTGSRCHTAVCQ----SPCLNGGKCV 3547
             CE   P    PC +GGRC  AP Q   C CP GW G RC   V +    +PC   G C 
Sbjct: 768  QCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICT 827

Query: 3548 R---PNRCHCLSSWTGHNCSR 3565
                   C C   +TG +C +
Sbjct: 828  NLAGSFSCTCHGGYTGPSCDQ 848



 Score = 68.9 bits (167), Expect = 8e-11
 Identities = 39/108 (36%), Positives = 52/108 (48%), Gaps = 17/108 (15%)

Query: 3475 PCQNGGICQRPNA----CSCPEGWMGRLCEEPI--CI--LPCLNGGRC---VAPYQCDCP 3523
            PC++GG C+        CSCP+GW G  C++ +  C    PC   G C      + C C 
Sbjct: 779  PCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCH 838

Query: 3524 PGWTGSRCHTAV--CQ-SPCLNGGKC---VRPNRCHCLSSWTGHNCSR 3565
             G+TG  C   +  C  +PCLNGG C   V    C CL  + G  C+R
Sbjct: 839  GGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCAR 886



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 37/101 (36%), Positives = 50/101 (49%), Gaps = 13/101 (12%)

Query: 3476 CQNGGICQ---RPNACSCPEGWMGRLCE---EPICILPCLNGGRCVAP---YQCDCPPGW 3526
            C NGG C       +C C  G+ G  C+   +P    PCL+GG C A    ++C C   +
Sbjct: 933  CFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESF 992

Query: 3527 TGSRCHTAV---CQSPCLNGGKCVRPNR-CHCLSSWTGHNC 3563
            TG +C T V    + PC NGG+CV+    C C   W+G  C
Sbjct: 993  TGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLC 1033



 Score = 66.6 bits (161), Expect = 4e-10
 Identities = 38/109 (34%), Positives = 51/109 (46%), Gaps = 20/109 (18%)

Query: 3475 PCQNGGICQRPN-------ACSCPEGWMGRLCE--EPICILPCLNGGRC-VAP---YQCD 3521
            PC   G+CQ          +C CP G+ G  C   +P    PC +G RC V P   + C 
Sbjct: 86   PCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCS 145

Query: 3522 CPPGWTGSRCHTAVCQ----SPCLNGGKCVRPN---RCHCLSSWTGHNC 3563
            CPPG+ G  C + V +     PC +GG C+      RC C + +TG  C
Sbjct: 146  CPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLC 194



 Score = 64.7 bits (156), Expect = 2e-09
 Identities = 39/108 (36%), Positives = 48/108 (44%), Gaps = 19/108 (17%)

Query: 3475 PCQNGGIC----QRPNACSCPEGWMGRLC--EEPICILPCLNGGRC-------VAPYQCD 3521
            PC NGG C     R  AC CP GW+G  C  E+P    PC   G C        A + C 
Sbjct: 48   PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCR 107

Query: 3522 CPPGWTGSRCH--TAVCQSPCLNGGKC-VRPN---RCHCLSSWTGHNC 3563
            CP G+ G  C        SPC +G +C V P+    C C   + G +C
Sbjct: 108  CPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSC 155



 Score = 63.2 bits (152), Expect = 5e-09
 Identities = 40/106 (37%), Positives = 50/106 (47%), Gaps = 15/106 (14%)

Query: 3475 PCQNGGICQR---PNACSCPEGWMGRLCEEPI--C-ILPCLNGGRC---VAPYQCDCPPG 3525
            PC+N   C        C C  G+ G  CE  I  C   PC+NGG C   V  + C CP G
Sbjct: 439  PCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSG 498

Query: 3526 WTGSRCHTAV---CQSPCLNGGKCV-RPN--RCHCLSSWTGHNCSR 3565
            ++GS C   V     +PC NG KCV +P+   C C   + G  C R
Sbjct: 499  FSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDR 544



 Score = 61.2 bits (147), Expect = 2e-08
 Identities = 37/106 (34%), Positives = 47/106 (44%), Gaps = 14/106 (13%)

Query: 3475 PCQNGGICQR---PNACSCPEGWMGRLCEEPI--CILPCLNGGRC---VAPYQCDCPPGW 3526
            PC NGG CQ      +CSC  G+ G  C   +  C+      G C   VA + C CPPG+
Sbjct: 857  PCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGY 916

Query: 3527 TGSRCHTAV---CQSPCLNGGKC---VRPNRCHCLSSWTGHNCSRK 3566
             G  C   +     S C NGG C   V    C C   +TG +C  +
Sbjct: 917  GGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHE 962



 Score = 60.1 bits (144), Expect = 4e-08
 Identities = 49/164 (29%), Positives = 61/164 (37%), Gaps = 70/164 (42%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCE---------EPICILP-CLNGGRCV---APY 3518
            PCQ+GG C    A   CSCP G +G LCE          P+   P CL+ G CV     +
Sbjct: 1130 PCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGF 1189

Query: 3519 QCDCPPGWTGSRC---------------HTAVC--------------------------- 3536
            +C CPPG+TG RC               HT  C                           
Sbjct: 1190 RCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSP 1249

Query: 3537 --QSPCLNGGKCVRPN---------RCHCLSSWTGHNCSRKRRT 3569
                PC +GG+C RP+          CHC   + G  C R  R+
Sbjct: 1250 CESQPCQHGGQC-RPSPGPGGGLTFTCHCAQPFWGPRCERVARS 1292



 Score = 60.1 bits (144), Expect = 4e-08
 Identities = 58/218 (26%), Positives = 78/218 (35%), Gaps = 34/218 (15%)

Query: 1192 QVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCET--------DIDECSPLPCLNN 1243
            +V   C    C     CQQ  RG  C CP G +G  C +            C+  PCL+ 
Sbjct: 1288 RVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHG 1347

Query: 1244 GVCK--DLVGEFICECPSGYTGQRCE--ENINECSSSPCLNKGICVDGVAGYRC--TCVK 1297
            G C+   L   F C C  G+TG RCE      E S  P   +  C       RC   C  
Sbjct: 1348 GSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNS 1407

Query: 1298 ---GFVGLHCETEV----NECQSNPC---LNNAVCEDQVGGFLC-----KCPPGFLGTRC 1342
               G+ G  C   V     +C++  C    NN+ C+       C      C  G     C
Sbjct: 1408 PGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTC 1467

Query: 1343 GKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHC 1380
                ++  +    +G  C  G N+  C    G+ G  C
Sbjct: 1468 NPVYEKYCADHFADG-RCDQGCNTEEC----GWDGLDC 1500



 Score = 59.7 bits (143), Expect = 5e-08
 Identities = 58/217 (26%), Positives = 83/217 (38%), Gaps = 38/217 (17%)

Query: 3384 CREGFLLQGHGIITCN--PDETWTQTSAKCEKISCGPPAH-------VENAIAR------ 3428
            C  G  + G    +C   P  T T+  ++ ++    P  H       V+  + R      
Sbjct: 554  CHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTT 613

Query: 3429 GVHYQYG--DMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRA----VCRFPCQNGGIC 3482
            GV+ +    D  +  C  G   +G  R  C+    +T P +C          PC  GG C
Sbjct: 614  GVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGP-LCNVEINECASSPCGEGGSC 672

Query: 3483 ---QRPNACSCPEGWMGRLC---EEPICILPCLNGGRCVAP--YQCDCPPGWTGSRCHTA 3534
               +    C CP G +  LC     P    PC +G    AP  ++C C PGW+G RC  +
Sbjct: 673  VDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQS 732

Query: 3535 V----CQS-PCLNGGKCVRPN---RCHCLSSWTGHNC 3563
            +    C+S PC  GG C        C C     G  C
Sbjct: 733  LARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQC 769



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 35/106 (33%), Positives = 43/106 (40%), Gaps = 16/106 (15%)

Query: 3476 CQNGGICQRP---NACSCPEGWMGRLCEEPI---CILPCLNGGRC---VAPYQCDCPPGW 3526
            C NGG C      ++C C  GW G  C + I       C +G  C   VA + C CP G 
Sbjct: 285  CHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGK 344

Query: 3527 TGSRCH--TAVCQSPCLNGGKC-VRPNR----CHCLSSWTGHNCSR 3565
            TG  CH   A   +PC     C   P      C C   +TG  C +
Sbjct: 345  TGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQ 390



 Score = 53.9 bits (128), Expect = 3e-06
 Identities = 46/139 (33%), Positives = 58/139 (41%), Gaps = 44/139 (31%)

Query: 3464 SPPICRAV---CRF-PCQNGGICQRPN---------ACSCPEGWMG-------RLCEEPI 3503
            S P C+ V   C   PCQ+GG C RP+          C C + + G       R C E  
Sbjct: 1239 SGPRCQTVLSPCESQPCQHGGQC-RPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQ 1297

Query: 3504 CI--LPCLNGGRCVAPYQCDCPPGWTGSRC-----------HTAVCQSPCLNGGKCVRPN 3550
            C   +PC    R   P +C CPPG +G  C           + +   +PCL+GG C RP 
Sbjct: 1298 CPVGVPCQQTPR--GP-RCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSC-RPA 1353

Query: 3551 ------RCHCLSSWTGHNC 3563
                  RC C   WTG  C
Sbjct: 1354 PLAPFFRCACAQGWTGPRC 1372



 Score = 52.8 bits (125), Expect = 6e-06
 Identities = 40/131 (30%), Positives = 52/131 (39%), Gaps = 13/131 (9%)

Query: 1687 RISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLL--GDSRMFCTDNGSWNGVSPSCL 1744
            R SC  P     GF   D       ++  C +G       D R  C+    + G S    
Sbjct: 103  RFSCRCP----RGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRS- 157

Query: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEI 1804
            DVDEC VG  C    +CLN  GS+ C C   YT  G  C  P    AP    NG +  + 
Sbjct: 158  DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYT--GPLCENPAVPCAPSPCRNGGTCRQ- 214

Query: 1805 YTVGAEVTFSC 1815
                 ++T+ C
Sbjct: 215  ---SGDLTYDC 222



 Score = 49.3 bits (116), Expect = 7e-05
 Identities = 41/135 (30%), Positives = 48/135 (35%), Gaps = 36/135 (26%)

Query: 3466 PICRAVCR----FPCQNGGICQ---RPNACSCPEGWMGRLCEE-----------PICILP 3507
            P C  V R      C  G  CQ   R   C+CP G  G  C                  P
Sbjct: 1284 PRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAP 1343

Query: 3508 CLNGGRC----VAPY-QCDCPPGWTGSRCHTAVCQSPCLNGGKCVR--------PNRC-- 3552
            CL+GG C    +AP+ +C C  GWTG RC             +C R          RC  
Sbjct: 1344 CLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDR 1403

Query: 3553 HCLS---SWTGHNCS 3564
             C S    W G +CS
Sbjct: 1404 ECNSPGCGWDGGDCS 1418



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 28/77 (36%), Positives = 37/77 (48%), Gaps = 7/77 (9%)

Query: 1730 CTDNGSWNGVSPSCL-DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG----DGKNCA 1784
            C+    W G  P C  DVDECA  + C  H  C N+ GS+ C+C   YTG       N  
Sbjct: 796  CSCPQGWQG--PRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDC 853

Query: 1785 EPIKCKAPGNPENGHSS 1801
            +P  C   G+ ++G  S
Sbjct: 854  DPNPCLNGGSCQDGVGS 870



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 27/71 (38%), Positives = 29/71 (40%), Gaps = 13/71 (18%)

Query: 3507 PCLNGGRCVA----PYQCDCPPGWTGSRCHTA-VCQS-PCLNGGKC-------VRPNRCH 3553
            PC NGGRC         C CPPGW G RC     C S PC   G C            C 
Sbjct: 48   PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCR 107

Query: 3554 CLSSWTGHNCS 3564
            C   + G +CS
Sbjct: 108  CPRGFRGPDCS 118



 Score = 42.4 bits (98), Expect = 0.008
 Identities = 17/35 (48%), Positives = 24/35 (68%), Gaps = 1/35 (2%)

Query: 1745 DVDECAVGSDCSEHAS-CLNVDGSYICSCVPPYTG 1778
            DVDEC++G++  EH   C+N  GS++C C   YTG
Sbjct: 391  DVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTG 425



 Score = 39.7 bits (91), Expect = 0.054
 Identities = 68/294 (23%), Positives = 97/294 (32%), Gaps = 71/294 (24%)

Query: 281 CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPE--------- 331
           C  G + C+ +G  +C    G F C C +GY G   + +   C SG  + +         
Sbjct: 395 CSIGANPCEHLG--RCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQ 452

Query: 332 -------GSPG-----GISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCEL-VHC 378
                  G  G      I  C   P  N        +   C C  G+  SG TC+L V  
Sbjct: 453 FTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGF--SGSTCQLDVDE 510

Query: 379 PALKPPENGY----------------FIQNTCNNHFNAACGVRCHPG--FDLVGSSIILC 420
            A  P  NG                 F    C+ + +      CH G   D + S    C
Sbjct: 511 CASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCAC 570

Query: 421 LPNGLWSGSESY---CRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477
            P    +  ES    CR + C      +HG   C      Y   C           G+  
Sbjct: 571 APGYTGTRCESQVDECRSQPC------RHGG-KCLDLVDKYLCRC---------PSGTTG 614

Query: 478 LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQ 531
           + C+ N         C    C TF + +D  I+ ++C  QP   G +C V   +
Sbjct: 615 VNCEVNID------DCASNPC-TFGVCRDG-INRYDCVCQPGFTGPLCNVEINE 660



 Score = 39.3 bits (90), Expect = 0.071
 Identities = 67/294 (22%), Positives = 98/294 (33%), Gaps = 65/294 (22%)

Query: 281  CDEGKDCCDRMGSCKCGTH------TGHFECICEKGYYGKGLQYECTACP-----SGTYK 329
            C +  D C   G   CG H       G F C C  GY G     +   C      +G   
Sbjct: 807  CQQDVDEC--AGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSC 864

Query: 330  PEGSPGGISSCIPCPDENHTSPPGSTSPEDCV---CREGYRASGQTCELVHCPALKPPEN 386
             +G      SC+P        P  +   ++C+   C  G            CP   P   
Sbjct: 865  QDGVGSFSCSCLP----GFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCP---PGYG 917

Query: 387  GYFIQNTCNNHFNAAC--GVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQP 444
            G+  +    +   ++C  G  C  G   V S   LC P   ++G  ++C+    P L +P
Sbjct: 918  GFHCEQDLPDCSPSSCFNGGTCVDG---VNSFSCLCRPG--YTG--AHCQHEADPCLSRP 970

Query: 445  -KHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEP-----RCVERHC 498
              HG + CS     ++ TC         LE      CQ    W   +P     RCV+   
Sbjct: 971  CLHGGV-CSAAHPGFRCTC---------LESFTGPQCQTLVDWCSRQPCQNGGRCVQ--- 1017

Query: 499  STFQMPKDVIISPHNCGKQPAKFGTICYV---SCRQGFILSGVKEMLRCTTSGK 549
                       +   C   P   G +C +    CR+     GV+    C   G+
Sbjct: 1018 -----------TGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQ 1060



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 67/270 (24%), Positives = 95/270 (35%), Gaps = 46/270 (17%)

Query: 276  HCSY-LCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPS-----GTYK 329
            HC   L D     C   G+C  G ++  F C+C  GY G   Q+E   C S     G   
Sbjct: 920  HCEQDLPDCSPSSCFNGGTCVDGVNS--FSCLCRPGYTGAHCQHEADPCLSRPCLHGGVC 977

Query: 330  PEGSPGGISSCIPCPDENHTSPPGSTSPEDC---VCREGYRASGQTCELVHCPALKPPEN 386
                PG   +C+    E+ T P   T  + C    C+ G R   QT     CP   P  +
Sbjct: 978  SAAHPGFRCTCL----ESFTGPQCQTLVDWCSRQPCQNGGRCV-QTGAYCLCP---PGWS 1029

Query: 387  GYF--IQNTCNNHFNAACGVR----CHPGFDLV--GSSIILCLPNGLWSGSESYCRVRTC 438
            G    I++       A  GVR    C  G   V   SS     P G    + S+C     
Sbjct: 1030 GRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG---RTGSHCEQEVD 1086

Query: 439  PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHC 498
            P L QP     +C      Y   CL     GY  +  +    +  SQ       C++   
Sbjct: 1087 PCLAQPCQHGGTCRGYMGGYMCECL----PGYNGDNCEDDVDECASQPCQHGGSCID--- 1139

Query: 499  STFQMPKDVIISPHNCGKQPAKFGTICYVS 528
                     +++ + C   P   G +C ++
Sbjct: 1140 ---------LVARYLCSCPPGTLGVLCEIN 1160



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 29/92 (31%), Positives = 43/92 (46%), Gaps = 12/92 (13%)

Query: 1730 CTDNGSWNGVSPSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPI- 1787
            CT +G + G  PSC  D+++C   + C    SC +  GS+ CSC+P +   G  CA  + 
Sbjct: 835  CTCHGGYTG--PSCDQDINDCDP-NPCLNGGSCQDGVGSFSCSCLPGFA--GPRCARDVD 889

Query: 1788 KCKAPGNPENGHSSGEIYTVGAEVTFSCQEGY 1819
            +C +     N    G      A  T +C  GY
Sbjct: 890  ECLS-----NPCGPGTCTDHVASFTCTCPPGY 916



 Score = 36.2 bits (82), Expect = 0.60
 Identities = 22/74 (29%), Positives = 32/74 (43%), Gaps = 6/74 (8%)

Query: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEI 1804
            +VD C +   C    +C    G Y+C C+P Y GD  NC + +   A    ++G   G  
Sbjct: 1084 EVDPC-LAQPCQHGGTCRGYMGGYMCECLPGYNGD--NCEDDVDECASQPCQHG---GSC 1137

Query: 1805 YTVGAEVTFSCQEG 1818
              + A    SC  G
Sbjct: 1138 IDLVARYLCSCPPG 1151



 Score = 35.8 bits (81), Expect = 0.78
 Identities = 35/125 (28%), Positives = 44/125 (35%), Gaps = 24/125 (19%)

Query: 288 CDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDEN 347
           C     C  G   G F C C  GY G+  + +   C  G     G      +C+      
Sbjct: 128 CAHGARCSVGPD-GRFLCSCPPGYQGRSCRSDVDECRVGEPCRHG-----GTCL------ 175

Query: 348 HTSPPGSTSPEDCVCREGYRASGQTCELVHCP-ALKPPENGYFIQNTCNNHFNAACGVRC 406
             + PGS     C C  GY  +G  CE    P A  P  NG     TC    +      C
Sbjct: 176 --NTPGSFR---CQCPAGY--TGPLCENPAVPCAPSPCRNG----GTCRQSGDLTYDCAC 224

Query: 407 HPGFD 411
            PGF+
Sbjct: 225 LPGFE 229



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 41/156 (26%), Positives = 56/156 (35%), Gaps = 15/156 (9%)

Query: 1628 CSDCPRLGGSVPHLRTASEDLK-PGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCE 1686
            C+      G+  H R AS     P  K  L C      V NP     ++       P   
Sbjct: 318  CATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPC----HEDAICDTNPVNG 373

Query: 1687 RISCGVPPPLENGF--HSADDFYAGSTVTYQCNN-GYYLLGDSRMFCTDNGSWNGVSPSC 1743
            R  C  PP    G      D+   G+     C + G  +       C     + G  P C
Sbjct: 374  RAICTCPPGFTGGACDQDVDECSIGAN---PCEHLGRCVNTQGSFLCQCGRGYTG--PRC 428

Query: 1744 -LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778
              DV+EC  G  C   A+CL+  G + C C+  +TG
Sbjct: 429  ETDVNECLSGP-CRNQATCLDRIGQFTCICMAGFTG 463



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 64/296 (21%), Positives = 83/296 (28%), Gaps = 75/296 (25%)

Query: 280 LCDEGKDCC--DRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYK-------- 329
           LCD   D C  D     +C      F C C  GY G   + +   C S   +        
Sbjct: 541 LCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDL 600

Query: 330 --------PEGSPG-----GISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELV 376
                   P G+ G      I  C   P        G  +  DCVC+ G+       E+ 
Sbjct: 601 VDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDG-INRYDCVCQPGFTGPLCNVEIN 659

Query: 377 HCPALKPPENGYFIQNTCNNHFNAACGVRCHPG-------------------FDLVGSSI 417
            C +    E G  +     N F   C     P                    +D  G   
Sbjct: 660 ECASSPCGEGGSCVDG--ENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFR 717

Query: 418 ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA------------ 465
            +C P   WSG      +       QP     +CS+  M +  TC               
Sbjct: 718 CVCEPG--WSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPC 775

Query: 466 ----CDEGYRLEGS--DKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCG 515
               C+ G R E +      C     W G  PRC        Q   D    P  CG
Sbjct: 776 TPNPCEHGGRCESAPGQLPVCSCPQGWQG--PRC--------QQDVDECAGPAPCG 821



 Score = 34.7 bits (78), Expect = 1.7
 Identities = 48/200 (24%), Positives = 67/200 (33%), Gaps = 58/200 (29%)

Query: 1637 SVPHLRTASEDLKPGSKVNLFCDPGFQ-----------LVGNPVQY---CLNQ------- 1675
            S P    A   + P  +    C PG+Q            VG P ++   CLN        
Sbjct: 125  SSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQ 184

Query: 1676 --GQWTQPLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQC----------------- 1716
                +T PL     + C  P P  NG            +TY C                 
Sbjct: 185  CPAGYTGPLCENPAVPCA-PSPCRNGGTCRQS----GDLTYDCACLPGFEGQNCEVNVDD 239

Query: 1717 -------NNGYYLLGDSRMFCTDNGSWNGVSPSCL-DVDECAVGSD-CSEHASCLNVDGS 1767
                   N G  + G +   C     W G    C  DVDEC +  + C    +C N  G 
Sbjct: 240  CPGHRCLNGGTCVDGVNTYNCQCPPEWTG--QFCTEDVDECQLQPNACHNGGTCFNTLGG 297

Query: 1768 YICSCVPPYTGDGKNCAEPI 1787
            + C CV  +TG+  +C++ I
Sbjct: 298  HSCVCVNGWTGE--SCSQNI 315



 Score = 34.7 bits (78), Expect = 1.7
 Identities = 15/34 (44%), Positives = 19/34 (55%), Gaps = 1/34 (2%)

Query: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778
            DVDECA    C    SC+++   Y+CSC P   G
Sbjct: 1122 DVDECA-SQPCQHGGSCIDLVARYLCSCPPGTLG 1154



 Score = 33.5 bits (75), Expect = 3.9
 Identities = 26/90 (28%), Positives = 38/90 (42%), Gaps = 8/90 (8%)

Query: 1730 CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKC 1789
            CT    ++G S   LDVDECA  + C   A C++    Y C C   +  +G  C   +  
Sbjct: 493  CTCPSGFSG-STCQLDVDECA-STPCRNGAKCVDQPDGYECRCAEGF--EGTLCDRNVDD 548

Query: 1790 KAPGNPENGHSSGEIYTVGAEVTFSCQEGY 1819
             +P    +G     I    A  + +C  GY
Sbjct: 549  CSPDPCHHGRCVDGI----ASFSCACAPGY 574



 Score = 32.7 bits (73), Expect = 6.6
 Identities = 14/30 (46%), Positives = 17/30 (56%), Gaps = 4/30 (13%)

Query: 3538 SPCLNGGKCVR-PNR---CHCLSSWTGHNC 3563
            SPC NGG+C + P+R   C C   W G  C
Sbjct: 47   SPCANGGRCTQLPSREAACLCPPGWVGERC 76



 Score = 32.3 bits (72), Expect = 8.6
 Identities = 28/107 (26%), Positives = 42/107 (39%), Gaps = 14/107 (13%)

Query: 1716 CNNGYYLLGDSRMFCTDNGSWNGVSPSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVP 1774
            C  G    G +R  C     + G  P C ++++ECA  S C E  SC++ +  + C C P
Sbjct: 629  CTFGVCRDGINRYDCVCQPGFTG--PLCNVEINECA-SSPCGEGGSCVDGENGFRCLCPP 685

Query: 1775 PYTGDGKNCAEPIKCKAPGNP--ENGHSSGEIYTVGAEVTFSCQEGY 1819
                     + P  C  P +P      S G  Y         C+ G+
Sbjct: 686  G--------SLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGW 724


>gi|157419154 selectin P precursor [Homo sapiens]
          Length = 830

 Score =  255 bits (652), Expect = 5e-67
 Identities = 165/599 (27%), Positives = 267/599 (44%), Gaps = 53/599 (8%)

Query: 1755 CSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPEN-----GHSSGEIYTVGA 1809
            CS+   CL   G+Y CSC P + G    C    +C     P++      H  G  ++  +
Sbjct: 168  CSKQGECLETIGNYTCSCYPGFYGP--ECEYVRECGELELPQHVLMNCSHPLGN-FSFNS 224

Query: 1810 EVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENG---CIEEL-AFTF 1865
            + +F C +GYQ+ G +K+ CL SG W +  P C A  C    IPE G   C+    AF  
Sbjct: 225  QCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQH 284

Query: 1866 GSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGK----YILSGL 1921
             S  ++ C +G+ L G +   C A+  W+   PVC+ V+C   E  + G     + L+  
Sbjct: 285  QSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAF 344

Query: 1922 TYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCG--EPP--AIKDAVITGN 1977
             Y S+  + C  GY ++G  ++ C  SG W    P C  + C   E P     D   +  
Sbjct: 345  AYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLR 404

Query: 1978 NFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHR 2037
             F +    ++ C EG+ L G D + C   G+W+     C A+ C + P+ + A    +H 
Sbjct: 405  AFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHP 464

Query: 2038 L----FGDIAFYYCSDGYSLADNSQLLCNAQGKW--VPPEGQDMPRCIAHFCEKPPSVSY 2091
                 +  +  + C++G  L   S L C A G W  VPPE Q +P C       P + + 
Sbjct: 465  FGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIP-CTPLL--SPQNGTM 521

Query: 2092 SILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPS 2151
            + ++ +  + +   S   F C EG+ L+   +++C R G+W  SP    C  ++C E  +
Sbjct: 522  TCVQPLGSSSYK--STCQFICDEGYSLSGPERLDCTRSGRWTDSPP--MCEAIKCPELFA 577

Query: 2152 IMNGYASGSN----YSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEP 2207
               G    S+    ++ G+   +SC+ GF ++G     C  +G+WS+  PTC  ++    
Sbjct: 578  PEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPT 637

Query: 2208 PKVE----------NGFLEHTTGRI-FESEVRYQCNPGYKSVGSPVFVCQANRHWHSESP 2256
            P V+            +  H  G   F +   + CN G+  +G     C+ +  W + +P
Sbjct: 638  PGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTP 697

Query: 2257 ----LMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWN 2311
                + C  L   KP  +    + G NF  GS   F C EG  L G +   CQ++G W+
Sbjct: 698  ACRAVKCSELHVNKPIAMNCSNLWG-NFSYGSICSFHCLEGQLLNGSAQTACQENGHWS 755



 Score =  239 bits (611), Expect = 3e-62
 Identities = 168/678 (24%), Positives = 271/678 (39%), Gaps = 104/678 (15%)

Query: 2480 CGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCL 2539
            C +  H L    +C+ + C K  E L    +YT          SC  GF   GP      
Sbjct: 150  CLKKKHALCYTASCQDMSCSKQGECLETIGNYT---------CSCYPGFY--GPECEYVR 198

Query: 2540 ETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEES 2599
            E G+  ++ P    ++C  P           ++S+ +   + C  G+QV G +   C  S
Sbjct: 199  ECGE--LELPQHVLMNCSHPL---------GNFSFNSQCSFHCTDGYQVNGPSKLECLAS 247

Query: 2600 G-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVA 2658
            G W++  P C+   C  PP                       +++P              
Sbjct: 248  GIWTNKPPQCLAAQC--PP-----------------------LKIP-------------- 268

Query: 2659 KTWENTKESPATHSSN-FLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIEC 2717
                        HS+  F + +  S++C  G+ L+G  V+ C   G W   AP C +++C
Sbjct: 269  ----ERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQC 324

Query: 2718 DLPTAPENGFLR----FTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAI 2773
                AP  G +      T  + GS+ ++ C+PG+ + G D+  C+++  WS   P CEAI
Sbjct: 325  QHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAI 384

Query: 2774 SCKKPNPVMNGSIKGS----NYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICI 2829
            SC+     ++GS+  S     + Y +   + C  G++L G +   C +   W    P+C 
Sbjct: 385  SCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQ 444

Query: 2830 PVDCSSPPVSANGQVRGDE----YTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPD 2885
             + C   PV    +V        + +Q    +TCNEG LL GA    CLA G+W+   P+
Sbjct: 445  ALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPE 504

Query: 2886 CVPVRCATPPQLANGVTEGL----DYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEI 2941
            C  + C       NG    +       +     F C EGY L G  +L C   G W    
Sbjct: 505  CQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSP 564

Query: 2942 PLCKPVNC----GPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSG 2997
            P+C+ + C     P +           F  G    + C  G+KL G ++  C ++G WS 
Sbjct: 565  PMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSA 624

Query: 2998 SSPSCLP-CRCSTPVIE------------YGTVNGTDFDCGKAARIQCFKGFKLLGLSEI 3044
            + P+C       TP ++            Y   +   F         C  GF L+G S +
Sbjct: 625  TPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTL 684

Query: 3045 TCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKE----NVITYSCRSGYVIQGSS 3100
            +C   GQW++  P C    C  L +     ++ ++ W      ++ ++ C  G ++ GS+
Sbjct: 685  SCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSA 744

Query: 3101 DLICTEKGVWSQPYPVCE 3118
               C E G WS   P C+
Sbjct: 745  QTACQENGHWSTTVPTCQ 762



 Score =  235 bits (600), Expect = 5e-61
 Identities = 188/677 (27%), Positives = 282/677 (41%), Gaps = 66/677 (9%)

Query: 1874 NKGYTLAGDKESSCLANSSWSHSPPV-------CEPVKCSSPENIN--NGKYILSGLTYL 1924
            NK +T  G K++      +W+ + P        C  +   SP      N ++ L     L
Sbjct: 98   NKTWTWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHAL 157

Query: 1925 STASYSCDTGYSLQGP---SIIECTASGIWDRAPPACHLVF-CGEPPAIKDAVITGN--- 1977
               +   D   S QG    +I   T S       P C  V  CGE    +  ++  +   
Sbjct: 158  CYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPL 217

Query: 1978 -NFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAH 2036
             NF+F +  ++ C +GY + G   +ECLA G W+    QCLA  C    I +  +    H
Sbjct: 218  GNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLH 277

Query: 2037 RLFG----DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYS 2092
                        + C +G++L     + C A G W  P     P C A  C+   + S  
Sbjct: 278  SAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPA----PVCKAVQCQHLEAPSEG 333

Query: 2093 ILESVSK-AKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWN---PSPMSIQCIPVRCGE 2148
             ++ V     FA GS   F+C  G+ +     + C+  G W+   P+  +I C P+    
Sbjct: 334  TMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPV 393

Query: 2149 PPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPP 2208
              S M+   S   + +    ++ C +GF ++G     C+  GQW++P P C  + C + P
Sbjct: 394  HGS-MDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLP 452

Query: 2209 KVENGFLE--HTTGRI-FESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCG 2265
                  +   H  G   ++S   + CN G   VG+ V  C A  +W+S  P  C  + C 
Sbjct: 453  VPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPP-ECQAIPCT 511

Query: 2266 KPPPIQNGFMKGE----NFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPA 2321
                 QNG M       +    S  QF C+EGY L G     C +SG+W   S P C   
Sbjct: 512  PLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTD-SPPMCEAI 570

Query: 2322 KCPEPPLLEN-QLVLKELTTEVGVVT---FSCKEGHVLQGPSVLKCLPSQQWNDSFPVCK 2377
            KCPE    E   L   +   E  V +   FSC  G  L+GP+ ++C  S +W+ + P CK
Sbjct: 571  KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCK 630

Query: 2378 IVLCTPPPLISFGVPIPS---------------SALHFGSTVKYSCVGGFFLRGNSTTLC 2422
             +   P P    GV  P+                   F +T  + C  GF L G+ST  C
Sbjct: 631  GIASLPTP----GVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSC 686

Query: 2423 QPDGTWSSPLPECVPVECPQ---PEEIPNGIIDVQG-LAYLSTALYTCKPGFELVGNTTT 2478
            +P G W++  P C  V+C +    + I     ++ G  +Y S   + C  G  L G+  T
Sbjct: 687  RPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQT 746

Query: 2479 LCGENGHWLGGKPTCKA 2495
             C ENGHW    PTC+A
Sbjct: 747  ACQENGHWSTTVPTCQA 763



 Score =  233 bits (595), Expect = 2e-60
 Identities = 157/547 (28%), Positives = 243/547 (44%), Gaps = 45/547 (8%)

Query: 2102 FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSP---MSIQCIPVRCGEPPSIMNGYAS 2158
            F+  S  SF C +G+ +N  +K+EC+  G W   P   ++ QC P++  E  + M    S
Sbjct: 220  FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGN-MTCLHS 278

Query: 2159 GSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHT 2218
               +   +  ++SC +GF + G +   C A+G W++P P C  V C        G ++  
Sbjct: 279  AKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCV 338

Query: 2219 ---TGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFM 2275
               T   + S  +++C PGY+  G  +  C  + HW +  P  C  + C       +G M
Sbjct: 339  HPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPT-CEAISCEPLESPVHGSM 397

Query: 2276 KGEN----FEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLEN 2331
                    F+  +   F C EG+ L G     C   G+W   + P C   +C + P+   
Sbjct: 398  DCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPA-PVCQALQCQDLPVPNE 456

Query: 2332 QLVLKELTTEVG------VVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTP-- 2383
              V    +   G      V +F+C EG +L G SVL+CL +  WN   P C+ + CTP  
Sbjct: 457  ARV--NCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLL 514

Query: 2384 -PPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQ 2442
             P   +     P  +  + ST ++ C  G+ L G     C   G W+   P C  ++CP+
Sbjct: 515  SPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPE 574

Query: 2443 ---PEEIPNGIIDVQGLAYL-STALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIEC 2498
               PE+      D +G   + ST  ++C  GF+L G     C  +G W    PTCK I  
Sbjct: 575  LFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIAS 634

Query: 2499 LK------PKEILNGKFSYTDLH------YGQTVTYSCNRGFRLEGPSALTCLETGDWDV 2546
            L       P     G+ +    H      +  T  + CN GF L G S L+C  +G W  
Sbjct: 635  LPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTA 694

Query: 2547 DAPSCNAIHCDS---PQPIE-NGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-W 2601
              P+C A+ C      +PI  N      ++SYG+I  + C  G  + G A   C+E+G W
Sbjct: 695  VTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHW 754

Query: 2602 SSSIPTC 2608
            S+++PTC
Sbjct: 755  STTVPTC 761



 Score =  230 bits (586), Expect = 2e-59
 Identities = 163/613 (26%), Positives = 246/613 (40%), Gaps = 84/613 (13%)

Query: 1683 PHCERI-SCG---VPPP-LENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWN 1737
            P CE +  CG   +P   L N  H   +F   S  ++ C +GY + G S++ C  +G W 
Sbjct: 192  PECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWT 251

Query: 1738 GVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPEN 1797
               P CL              A C                        P+K    GN   
Sbjct: 252  NKPPQCL-------------AAQC-----------------------PPLKIPERGNMTC 275

Query: 1798 GHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENG- 1856
             HS+ + +   +  +FSC+EG+ L+G   + C  SG W    P CKAV C     P  G 
Sbjct: 276  LHSA-KAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGT 334

Query: 1857 --CIEEL-AFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINN 1913
              C+  L AF +GS   + C  GY + G     C+ +  WS   P CE + C   E+  +
Sbjct: 335  MDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVH 394

Query: 1914 GKY----ILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAI 1969
            G       L    Y +  S+ C  G+ L+G  I+ C   G W    P C  + C + P  
Sbjct: 395  GSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVP 454

Query: 1970 KDAVITGNN----FTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPP 2025
             +A +  ++    F +++  ++TC EG  L G   ++CLA G W+    +C A+ C  P 
Sbjct: 455  NEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPC-TPL 513

Query: 2026 IVDHASPETAHRLFGDIAF-----YYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIA 2080
            +       T  +  G  ++     + C +GYSL+   +L C   G+W        P C A
Sbjct: 514  LSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWT----DSPPMCEA 569

Query: 2081 HFCEKPPSVSYSILE-SVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMS- 2138
              C +  +     L+ S ++ +F  GS   F C  GF L     +EC   G+W+ +P + 
Sbjct: 570  IKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTC 629

Query: 2139 ----------IQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEA 2188
                      +QC P         M        + F     + CN GF + G+   +C  
Sbjct: 630  KGIASLPTPGVQC-PALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRP 688

Query: 2189 TGQWSSPIPTCHPVSCGE----PPKVENGFLEHTTGRI-FESEVRYQCNPGYKSVGSPVF 2243
            +GQW++  P C  V C E     P   N    +  G   + S   + C  G    GS   
Sbjct: 689  SGQWTAVTPACRAVKCSELHVNKPIAMN--CSNLWGNFSYGSICSFHCLEGQLLNGSAQT 746

Query: 2244 VCQANRHWHSESP 2256
             CQ N HW +  P
Sbjct: 747  ACQENGHWSTTVP 759



 Score =  220 bits (561), Expect = 2e-56
 Identities = 157/548 (28%), Positives = 224/548 (40%), Gaps = 57/548 (10%)

Query: 2279 NFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLE--NQLVLK 2336
            NF   S+  F C +GY++ G S   C  SG W  K  P+C+ A+CP   + E  N   L 
Sbjct: 219  NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKP-PQCLAAQCPPLKIPERGNMTCLH 277

Query: 2337 ELTT--EVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPI- 2393
                       +FSC+EG  L GP V++C  S  W    PVCK V C      S G    
Sbjct: 278  SAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDC 337

Query: 2394 --PSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGII 2451
              P +A  +GS+ K+ C  G+ +RG     C   G WS+PLP C  + C   E   +G +
Sbjct: 338  VHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSM 397

Query: 2452 D----VQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLK---PKEI 2504
            D    ++   Y +   + C  GF L G     C   G W    P C+A++C     P E 
Sbjct: 398  DCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEA 457

Query: 2505 -LNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIE 2563
             +N    +    Y    +++CN G  L G S L CL TG+W+   P C AI C      +
Sbjct: 458  RVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQ 517

Query: 2564 NGFVEGAD----YSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPTCMPIDCG--LP 2616
            NG +         SY +   + C  G+ ++G     C  SG W+ S P C  I C     
Sbjct: 518  NGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFA 577

Query: 2617 PHIDFGDCTKLKD------------DQGYFEQEDDMMEVPYV---------------TPH 2649
            P     DC+  +             D G+  +  + +E                    P 
Sbjct: 578  PEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPT 637

Query: 2650 PPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSA 2709
            P     A+    + T      H   F + T   + CN G+ L+G+  L C+  G W    
Sbjct: 638  PGVQCPALTTPGQGTMYC-RHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVT 696

Query: 2710 PSCISIEC-----DLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWS 2764
            P+C +++C     + P A     L +   S GS   + C  G +L GS    C EN  WS
Sbjct: 697  PACRAVKCSELHVNKPIAMNCSNL-WGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWS 755

Query: 2765 GASPRCEA 2772
               P C+A
Sbjct: 756  TTVPTCQA 763



 Score =  220 bits (560), Expect = 2e-56
 Identities = 164/592 (27%), Positives = 246/592 (41%), Gaps = 69/592 (11%)

Query: 1652 SKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPL---ENG----FHSAD 1704
            S+ +  C  G+Q+ G     CL  G WT   P C    C   PPL   E G     HSA 
Sbjct: 224  SQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQC---PPLKIPERGNMTCLHSAK 280

Query: 1705 DFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDEC------AVGS-DCSE 1757
             F   S+ ++ C  G+ L+G   + CT +G W   +P C  V +C      + G+ DC  
Sbjct: 281  AFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAV-QCQHLEAPSEGTMDCVH 339

Query: 1758 HASCLNVDGSYICSCVPPYTGDGKNC---------------AEPIKCKAPGNPENGHS-- 1800
              +      S    C P Y   G +                 E I C+   +P +G    
Sbjct: 340  PLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDC 399

Query: 1801 --SGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENG-- 1856
              S   +      +F C EG+ L G   + C   G+W    P C+A+ C    +P     
Sbjct: 400  SPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARV 459

Query: 1857 -CIEEL-AFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNG 1914
             C     AF + S  ++ CN+G  L G     CLA  +W+  PP C+ + C+   +  NG
Sbjct: 460  NCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNG 519

Query: 1915 KYI----LSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIK 1970
                   L   +Y ST  + CD GYSL GP  ++CT SG W  +PP C  + C E  A +
Sbjct: 520  TMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPE 579

Query: 1971 ----DAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPI 2026
                D   T   F   +T  ++C  G+ L G + +EC   G+WS +   C  ++    P 
Sbjct: 580  QGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPG 639

Query: 2027 VDHASPETAHR------------LFGDIAFYYCSDGYSLADNSQLLCNAQGKW--VPPEG 2072
            V   +  T  +             F    ++ C+ G++L  +S L C   G+W  V P  
Sbjct: 640  VQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPAC 699

Query: 2073 QDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQW 2132
            + + +C      KP +++ S L       F+ GS+ SF C+EG +LN SA+  C   G W
Sbjct: 700  RAV-KCSELHVNKPIAMNCSNL----WGNFSYGSICSFHCLEGQLLNGSAQTACQENGHW 754

Query: 2133 NPSPMSIQCIPVRCGEPPSIMNG-YASGSNYSFGAMVAYSCNKGFYIKGEKK 2183
            + +  + Q  P+   E  +   G  AS      G  +     K F  K + K
Sbjct: 755  STTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLALLRKRFRQKDDGK 806



 Score =  218 bits (554), Expect = 1e-55
 Identities = 161/576 (27%), Positives = 240/576 (41%), Gaps = 55/576 (9%)

Query: 2021 CDEPPIVDHASPETAHRLFGDIAF-----YYCSDGYSLADNSQLLCNAQGKWVPPEGQDM 2075
            C E  +  H     +H L G+ +F     ++C+DGY +   S+L C A G W        
Sbjct: 200  CGELELPQHVLMNCSHPL-GNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWT----NKP 254

Query: 2076 PRCIAHFCEKPPSVSYSILESVSKAK-FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWN- 2133
            P+C+A  C          +  +  AK F   S  SF C EGF L     ++C   G W  
Sbjct: 255  PQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTA 314

Query: 2134 PSPMSIQCIPVRCG--EPPS--IMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEAT 2189
            P+P+   C  V+C   E PS   M+     + +++G+   + C  G+ ++G     C  +
Sbjct: 315  PAPV---CKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDS 371

Query: 2190 GQWSSPIPTCHPVSCGEPPKVENGFLEHTTG-RIFESEVR--YQCNPGYKSVGSPVFVCQ 2246
            G WS+P+PTC  +SC       +G ++ +   R F+ +    ++C  G+   G+ +  C 
Sbjct: 372  GHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCD 431

Query: 2247 ANRHWHSESPLMCVPLDCGKPPPIQNGFMKGEN----FEVGSKVQFFCNEGYELVGDSSW 2302
                W + +P+ C  L C   P      +   +    F   S   F CNEG  LVG S  
Sbjct: 432  NLGQWTAPAPV-CQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVL 490

Query: 2303 TCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVG------VVTFSCKEGHVLQ 2356
             C  +G WN    P+C    C   PLL  Q         +G         F C EG+ L 
Sbjct: 491  QCLATGNWNSVP-PECQAIPCT--PLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLS 547

Query: 2357 GPSVLKCLPSQQWNDSFPVCKIVLCTP---PPLISFGVPIPSSALHFGSTVKYSCVGGFF 2413
            GP  L C  S +W DS P+C+ + C     P   S          + GST  +SC  GF 
Sbjct: 548  GPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFK 607

Query: 2414 LRGNSTTLCQPDGTWSSPLPECVPV-ECPQPE-EIPNGIIDVQGLAYL----------ST 2461
            L G +   C   G WS+  P C  +   P P  + P      QG  Y           +T
Sbjct: 608  LEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTT 667

Query: 2462 ALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIEC----LKPKEILNGKFSYTDLHYG 2517
              + C  GF L+G++T  C  +G W    P C+A++C    +     +N    + +  YG
Sbjct: 668  CYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYG 727

Query: 2518 QTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNA 2553
               ++ C  G  L G +   C E G W    P+C A
Sbjct: 728  SICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQA 763



 Score =  216 bits (551), Expect = 2e-55
 Identities = 155/583 (26%), Positives = 236/583 (40%), Gaps = 71/583 (12%)

Query: 2938 DAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSG 2997
            + E+P    +NC  P          FSF       + C  GY+++G S   CL++G W+ 
Sbjct: 202  ELELPQHVLMNCSHPL-------GNFSF--NSQCSFHCTDGYQVNGPSKLECLASGIWTN 252

Query: 2998 SSPSCLPCRCSTPVI-EYGTV----NGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQW 3052
              P CL  +C    I E G +    +   F    +    C +GF L+G   + C A G W
Sbjct: 253  KPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVW 312

Query: 3053 SSGFPHCEHTSC--------GSLPMI-PNAFISETSSWKENVITYSCRSGYVIQGSSDLI 3103
            ++  P C+   C        G++  + P    +  SS K     + C+ GY ++G   L 
Sbjct: 313  TAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCK-----FECQPGYRVRGLDMLR 367

Query: 3104 CTEKGVWSQPYPVCEPLSCGSPPSVANAVA----TGEAHTYESEVKLRCLEGYTMDTDTD 3159
            C + G WS P P CE +SC    S  +       +  A  Y++    RC EG+ +    D
Sbjct: 368  CIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFML-RGAD 426

Query: 3160 TFTCQKDGRWFPERISCSPKKC---PLPENITHILVHG-DDFSVNRQVSVSCAEGYTFEG 3215
               C   G+W      C   +C   P+P        H    F      S +C EG    G
Sbjct: 427  IVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVG 486

Query: 3216 VNISVCQLDGTWE--PPFSDESCSPVSCGKPESPEHGFV-----VGSKYTFESTIIYQCE 3268
             ++  C   G W   PP     C  + C    SP++G +     +GS  +++ST  + C+
Sbjct: 487  ASVLQCLATGNWNSVPP----ECQAIPCTPLLSPQNGTMTCVQPLGSS-SYKSTCQFICD 541

Query: 3269 PGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENR----TTGPNVVYS 3324
             GY L G     C  + +W+    +C+  +C        G  D  +       G    +S
Sbjct: 542  EGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFS 601

Query: 3325 CNRGYSLEGPSEAHCTENGTWSHPVPLCK-----PNP---CPVPFVIPENALLSEKE--- 3373
            C+ G+ LEGP+   CT +G WS   P CK     P P   CP      +  +        
Sbjct: 602  CDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGT 661

Query: 3374 FYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGV--- 3430
            F  +      C  GF L G   ++C P   WT  +  C  + C    HV   IA      
Sbjct: 662  FGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSE-LHVNKPIAMNCSNL 720

Query: 3431 --HYQYGDMITYSCYSGYMLEGFLRSVCLENGTW-TSPPICRA 3470
              ++ YG + ++ C  G +L G  ++ C ENG W T+ P C+A
Sbjct: 721  WGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQA 763



 Score =  214 bits (546), Expect = 9e-55
 Identities = 169/650 (26%), Positives = 271/650 (41%), Gaps = 78/650 (12%)

Query: 2757 CLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQ 2816
            CL+ +     +  C+ +SC K    +       NYT        C PG+   G E   C+
Sbjct: 150  CLKKKHALCYTASCQDMSCSKQGECLETI---GNYTC------SCYPGFY--GPE---CE 195

Query: 2817 DDKNWDEDE-PICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLA 2875
              +   E E P  + ++CS P            ++F  +  + C +G+ + G     CLA
Sbjct: 196  YVRECGELELPQHVLMNCSHPL---------GNFSFNSQCSFHCTDGYQVNGPSKLECLA 246

Query: 2876 NGSWSGATPDCVPVRCATP--PQLANGVTEGLDYGFMKE--VTFHCHEGYILHGAPKLTC 2931
            +G W+   P C+  +C     P+  N         F  +   +F C EG+ L G   + C
Sbjct: 247  SGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQC 306

Query: 2932 QSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGF----SFIHGGHIQYQCFPGYKLHGNSSR 2987
             + G W A  P+CK V C   E  + G  +      +F +G   +++C PGY++ G    
Sbjct: 307  TASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDML 366

Query: 2988 RCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAAR---------IQCFKGFKL 3038
            RC+ +G WS   P+C    C    +E   V+G+  DC  + R          +C +GF L
Sbjct: 367  RCIDSGHWSAPLPTCEAISCEP--LE-SPVHGS-MDCSPSLRAFQYDTNCSFRCAEGFML 422

Query: 3039 LGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWK----ENVITYSCRSGY 3094
             G   + C+  GQW++  P C+   C  LP+   A ++ +  +     ++V +++C  G 
Sbjct: 423  RGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGL 482

Query: 3095 VIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGE----AHTYESEVKLRCLE 3150
            ++ G+S L C   G W+   P C+ + C    S  N   T      + +Y+S  +  C E
Sbjct: 483  LLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDE 542

Query: 3151 GYTMDTDTDTFTCQKDGRWFPERISCSPKKCP---LPENITHILVHGD---DFSVNRQVS 3204
            GY++ +  +   C + GRW      C   KCP    PE  +  L   D   +F+V     
Sbjct: 543  GYSL-SGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGS--LDCSDTRGEFNVGSTCH 599

Query: 3205 VSCAEGYTFEGVNISVCQLDGTWE--PPFSDESCS----PVSCGKPESPEHGFVV----G 3254
             SC  G+  EG N   C   G W   PP      S     V C    +P  G +      
Sbjct: 600  FSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHP 659

Query: 3255 SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCET-----PLEFLNGK 3309
              + F +T  + C  G+ L G+    C+ + QW+     C+  +C       P+  +N  
Sbjct: 660  GTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIA-MNCS 718

Query: 3310 ADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPV 3359
                N + G    + C  G  L G ++  C ENG WS  VP C+  P  +
Sbjct: 719  NLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTI 768



 Score =  206 bits (525), Expect = 3e-52
 Identities = 123/448 (27%), Positives = 192/448 (42%), Gaps = 71/448 (15%)

Query: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSADD----- 1705
            GS     C PG+++ G  +  C++ G W+ PLP CE ISC    PLE+  H + D     
Sbjct: 347  GSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISC---EPLESPVHGSMDCSPSL 403

Query: 1706 --FYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLN 1763
              F   +  +++C  G+ L G   + C + G W   +P C  +                 
Sbjct: 404  RAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQ---------------- 447

Query: 1764 VDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMG 1823
                  C  +P       NC+ P                  +   +  +F+C EG  L+G
Sbjct: 448  ------CQDLPVPNEARVNCSHPFGA---------------FRYQSVCSFTCNEGLLLVG 486

Query: 1824 VTKITCLESGEWNHLIPYCKAVSCGKPAIPENG---CIEEL-AFTFGSKVTYRCNKGYTL 1879
             + + CL +G WN + P C+A+ C     P+NG   C++ L + ++ S   + C++GY+L
Sbjct: 487  ASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSL 546

Query: 1880 AGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSG----LTYLSTASYSCDTGY 1935
            +G +   C  +  W+ SPP+CE +KC        G    S         ST  +SCD G+
Sbjct: 547  SGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGF 606

Query: 1936 SLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVIT------------GNNFTFRN 1983
             L+GP+ +ECT SG W   PP C  +     P ++   +T               F F  
Sbjct: 607  KLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNT 666

Query: 1984 TVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDE----PPIVDHASPETAHRLF 2039
            T  + C  G+TL G  T+ C   G+W+     C AV C E     PI  + S    +  +
Sbjct: 667  TCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSY 726

Query: 2040 GDIAFYYCSDGYSLADNSQLLCNAQGKW 2067
            G I  ++C +G  L  ++Q  C   G W
Sbjct: 727  GSICSFHCLEGQLLNGSAQTACQENGHW 754



 Score =  200 bits (508), Expect = 2e-50
 Identities = 172/700 (24%), Positives = 263/700 (37%), Gaps = 95/700 (13%)

Query: 2060 LCNAQGKWV---PPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCM--- 2113
            L N    W    P   ++   C+  + + P +      E   K K A     S + M   
Sbjct: 110  LTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCS 169

Query: 2114 -EGFVLNTSAKIECMRGGQWNPSPMSIQCIPVR-CGE----PPSIMNGYASGSNYSFGAM 2167
             +G  L T     C       P     +C  VR CGE       +MN      N+SF + 
Sbjct: 170  KQGECLETIGNYTC----SCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQ 225

Query: 2168 VAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENG---FLEHTTGRIFE 2224
             ++ C  G+ + G  K  C A+G W++  P C    C      E G    L        +
Sbjct: 226  CSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQ 285

Query: 2225 SEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGEN----F 2280
            S   + C  G+  VG  V  C A+  W + +P+ C  + C        G M   +    F
Sbjct: 286  SSCSFSCEEGFALVGPEVVQCTASGVWTAPAPV-CKAVQCQHLEAPSEGTMDCVHPLTAF 344

Query: 2281 EVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNP----KCMPAKCPEPPLLENQLVLK 2336
              GS  +F C  GY + G     C  SG W+          C P + P    ++    L+
Sbjct: 345  AYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLR 404

Query: 2337 ELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLIS---FGVPI 2393
                +    +F C EG +L+G  +++C    QW    PVC+ + C   P+ +        
Sbjct: 405  AFQYDTNC-SFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSH 463

Query: 2394 PSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIID- 2452
            P  A  + S   ++C  G  L G S   C   G W+S  PEC  + C       NG +  
Sbjct: 464  PFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTC 523

Query: 2453 VQGL---AYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKF 2509
            VQ L   +Y ST  + C  G+ L G     C  +G W    P C+AI+C +      G  
Sbjct: 524  VQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSL 583

Query: 2510 SYTD----LHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAI--------HCD 2557
              +D     + G T  +SC+ GF+LEGP+ + C  +G W    P+C  I         C 
Sbjct: 584  DCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCP 643

Query: 2558 SPQPIENGFV----EGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPTCMPID 2612
            +      G +        + +     + C  GF + G +  +C  SG W++  P C  + 
Sbjct: 644  ALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVK 703

Query: 2613 CGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHS 2672
            C    H+                             + P  +   +  W           
Sbjct: 704  CS-ELHV-----------------------------NKPIAMNC-SNLW----------- 721

Query: 2673 SNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSC 2712
             NF YG++ S+ C  G  L G+    CQE+G W+ + P+C
Sbjct: 722  GNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761



 Score =  196 bits (499), Expect = 3e-49
 Identities = 171/674 (25%), Positives = 267/674 (39%), Gaps = 86/674 (12%)

Query: 2809 GTERRTCQDDKNWDEDEP-------ICIPVDCSSPPVSANGQVRGDEYTFQKE--IEYTC 2859
            GT++    + +NW ++EP        C+ +   SP  SA G+   DE+  +K+  + YT 
Sbjct: 105  GTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSP--SAPGK-WNDEHCLKKKHALCYTA 161

Query: 2860 N--------EGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGL-----D 2906
            +        +G  LE   +  C     + G  P+C  VR     +L   V         +
Sbjct: 162  SCQDMSCSKQGECLETIGNYTCSCYPGFYG--PECEYVRECGELELPQHVLMNCSHPLGN 219

Query: 2907 YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHG----FPNG 2962
            + F  + +FHC +GY ++G  KL C + G W  + P C    C P +    G      + 
Sbjct: 220  FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSA 279

Query: 2963 FSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCS-TPVIEYGTVNG-- 3019
             +F H     + C  G+ L G    +C ++G W+  +P C   +C        GT++   
Sbjct: 280  KAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVH 339

Query: 3020 --TDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSC--------GSLPM 3069
              T F  G + + +C  G+++ GL  + C   G WS+  P CE  SC        GS+  
Sbjct: 340  PLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDC 399

Query: 3070 IPN--AFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPS 3127
             P+  AF  +T+       ++ C  G++++G+  + C   G W+ P PVC+ L C   P 
Sbjct: 400  SPSLRAFQYDTN------CSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLP- 452

Query: 3128 VANAVATGEAH-----TYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFP-----ERISCS 3177
            V N      +H      Y+S     C EG  +        C   G W       + I C+
Sbjct: 453  VPNEARVNCSHPFGAFRYQSVCSFTCNEGLLL-VGASVLQCLATGNWNSVPPECQAIPCT 511

Query: 3178 PKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCS 3237
            P   P    +T +   G   S        C EGY+  G     C   G W    S   C 
Sbjct: 512  PLLSPQNGTMTCVQPLGSS-SYKSTCQFICDEGYSLSGPERLDCTRSGRWTD--SPPMCE 568

Query: 3238 PVSCGKPESPEHGFV----VGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSG---- 3289
             + C +  +PE G +       ++   ST  + C+ G++LEG     C  + +WS     
Sbjct: 569  AIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPT 628

Query: 3290 --GVAICKETRCETPLEFLNGKADIENR----TTGPNVV--YSCNRGYSLEGPSEAHCTE 3341
              G+A       + P     G+  +  R    T G N    + CN G++L G S   C  
Sbjct: 629  CKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRP 688

Query: 3342 NGTWSHPVPLCKPNPCPVPFV---IPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC 3398
            +G W+   P C+   C    V   I  N       F      S  C EG LL G     C
Sbjct: 689  SGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTAC 748

Query: 3399 NPDETWTQTSAKCE 3412
              +  W+ T   C+
Sbjct: 749  QENGHWSTTVPTCQ 762



 Score =  171 bits (433), Expect = 1e-41
 Identities = 151/589 (25%), Positives = 217/589 (36%), Gaps = 76/589 (12%)

Query: 2969 GHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAA 3028
            G+    C+PG+  +G         G      P  +   CS P+         +F      
Sbjct: 179  GNYTCSCYPGF--YGPECEYVRECGELE--LPQHVLMNCSHPL--------GNFSFNSQC 226

Query: 3029 RIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWK----EN 3084
               C  G+++ G S++ C A G W++  P C    C  L +     ++   S K    ++
Sbjct: 227  SFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQS 286

Query: 3085 VITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCG--SPPS--VANAVATGEAHTY 3140
              ++SC  G+ + G   + CT  GVW+ P PVC+ + C     PS    + V    A  Y
Sbjct: 287  SCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAY 346

Query: 3141 ESEVKLRCLEGYTMDTDTDTFTCQKDGRWFP-----ERISCSPKKCPLPENITHILVHGD 3195
             S  K  C  GY +    D   C   G W       E ISC P + P         VHG 
Sbjct: 347  GSSCKFECQPGYRV-RGLDMLRCIDSGHWSAPLPTCEAISCEPLESP---------VHGS 396

Query: 3196 --------DFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESP 3247
                     F  +   S  CAEG+   G +I  C   G W  P     C  + C     P
Sbjct: 397  MDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAP--VCQALQCQDLPVP 454

Query: 3248 EHGFVVGSK----YTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPL 3303
                V  S     + ++S   + C  G  L G     C     W+     C+   C   L
Sbjct: 455  NEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLL 514

Query: 3304 EFLNGKAD----IENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPV 3359
               NG       + + +      + C+ GYSL GP    CT +G W+   P+C+   CP 
Sbjct: 515  SPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPE 574

Query: 3360 PFVIPENALL----SEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKIS 3415
             F  PE   L    +  EF V       C  GF L+G   + C     W+ T   C+ I+
Sbjct: 575  LFA-PEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIA 633

Query: 3416 CGPPAHVE----NAIARGVHY--------QYGDMITYSCYSGYMLEGFLRSVCLENGTWT 3463
              P   V+        +G  Y         +     + C +G+ L G     C  +G WT
Sbjct: 634  SLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWT 693

Query: 3464 S-PPICRAVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNG 3511
            +  P CRAV    C    +  +P A +C   W G      IC   CL G
Sbjct: 694  AVTPACRAV---KCSELHV-NKPIAMNCSNLW-GNFSYGSICSFHCLEG 737



 Score =  140 bits (354), Expect = 2e-32
 Identities = 114/428 (26%), Positives = 172/428 (40%), Gaps = 66/428 (15%)

Query: 3183 LPENITHILVHG-DDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTW--EPPFSDESCSPV 3239
            LP+++     H   +FS N Q S  C +GY   G +   C   G W  +PP     C   
Sbjct: 205  LPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPP----QCLAA 260

Query: 3240 SCGKPESPEHGFVV----GSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICK 3295
             C   + PE G +        +  +S+  + CE G+ L G     C  +  W+    +CK
Sbjct: 261  QCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCK 320

Query: 3296 ETRCETPLEFLNGKADIENRTT----GPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPL 3351
              +C+       G  D  +  T    G +  + C  GY + G     C ++G WS P+P 
Sbjct: 321  AVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPT 380

Query: 3352 CKPNPCPVPFVIPENALL----SEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQT 3407
            C+   C  P   P +  +    S + F  D N S +C EGF+L+G  I+ C+    WT  
Sbjct: 381  CEAISCE-PLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAP 439

Query: 3408 SAKCEKISCGPPAHVENAIARGVH----YQYGDMITYSCYSGYMLEGFLRSVCLENGTWT 3463
            +  C+ + C        A     H    ++Y  + +++C  G +L G     CL  G W 
Sbjct: 440  APVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWN 499

Query: 3464 S-PPICRAVCRFPC------QNGGI-CQRPNACSCPEGWMGRLCEEPICI-----LPCLN 3510
            S PP C+A+   PC      QNG + C +P   S  +     +C+E   +     L C  
Sbjct: 500  SVPPECQAI---PCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTR 556

Query: 3511 GGRCV-APYQCD---CPPGWT-----------------GSRCHTAVCQSPCLNGGKCVRP 3549
             GR   +P  C+   CP  +                  GS CH +     C NG K   P
Sbjct: 557  SGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFS-----CDNGFKLEGP 611

Query: 3550 NRCHCLSS 3557
            N   C +S
Sbjct: 612  NNVECTTS 619



 Score =  122 bits (307), Expect = 5e-27
 Identities = 84/306 (27%), Positives = 124/306 (40%), Gaps = 36/306 (11%)

Query: 288 CDRMGSCKCGTHTGHFECICEKGYYGKGLQY--ECTACPSGTY------KPEGSPGGISS 339
           C + G C      G++ C C  G+YG   +Y  EC       +       P G+    S 
Sbjct: 168 CSKQGECL--ETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQ 225

Query: 340 C-IPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHF 398
           C   C D    + P   S  +C+    +      C    CP LK PE G     TC +  
Sbjct: 226 CSFHCTDGYQVNGP---SKLECLASGIWTNKPPQCLAAQCPPLKIPERG---NMTCLHSA 279

Query: 399 NA-----ACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISC-- 451
            A     +C   C  GF LVG  ++ C  +G+W+     C+   C HL  P  G + C  
Sbjct: 280 KAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVH 339

Query: 452 STREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
                 Y ++C   C  GYR+ G D L C  +  W  P P C    C   + P   +   
Sbjct: 340 PLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESP---VHGS 396

Query: 512 HNCGK--QPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGV---QAAVCKDVEAP- 565
            +C    +  ++ T C   C +GF+L G  +++RC   G+W       QA  C+D+  P 
Sbjct: 397 MDCSPSLRAFQYDTNCSFRCAEGFMLRGA-DIVRCDNLGQWTAPAPVCQALQCQDLPVPN 455

Query: 566 --QINC 569
             ++NC
Sbjct: 456 EARVNC 461



 Score =  109 bits (272), Expect = 6e-23
 Identities = 60/216 (27%), Positives = 93/216 (43%), Gaps = 13/216 (6%)

Query: 360 CVCREGYRASGQTCELVHCPALKPPENGYF--IQNTCNNHFNAACGVRCHPGFDLVGSSI 417
           C     + A    C+ V C  L+ P  G    +       + ++C   C PG+ + G  +
Sbjct: 306 CTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDM 365

Query: 418 ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCST--REMLYKTTCLVACDEGYRLEGS 475
           + C+ +G WS     C   +C  L  P HG + CS   R   Y T C   C EG+ L G+
Sbjct: 366 LRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGA 425

Query: 476 DKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQ--PAKFGTICYVSCRQGF 533
           D + C    QW  P P C    C    +P +  +   NC       ++ ++C  +C +G 
Sbjct: 426 DIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARV---NCSHPFGAFRYQSVCSFTCNEGL 482

Query: 534 ILSGVKEMLRCTTSGKWN---VGVQAAVCKDVEAPQ 566
           +L G   +L+C  +G WN      QA  C  + +PQ
Sbjct: 483 LLVGA-SVLQCLATGNWNSVPPECQAIPCTPLLSPQ 517



 Score =  107 bits (268), Expect = 2e-22
 Identities = 64/217 (29%), Positives = 97/217 (44%), Gaps = 21/217 (9%)

Query: 366 YRASGQTCELVHCPALKPPENGYFIQNTCNNHFNA-----ACGVRCHPGFDLVGSSIILC 420
           + A    C+ + C  L  P      +  C++ F A      C   C+ G  LVG+S++ C
Sbjct: 436 WTAPAPVCQALQCQDLPVPNEA---RVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQC 492

Query: 421 LPNGLWSGSESYCRVRTCPHLRQPKHGHISC--STREMLYKTTCLVACDEGYRLEGSDKL 478
           L  G W+     C+   C  L  P++G ++C        YK+TC   CDEGY L G ++L
Sbjct: 493 LATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERL 552

Query: 479 TCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQGFILS 536
            C  + +W    P C    C     P+   +   +C     +F  G+ C+ SC  GF L 
Sbjct: 553 DCTRSGRWTDSPPMCEAIKCPELFAPEQGSL---DCSDTRGEFNVGSTCHFSCDNGFKLE 609

Query: 537 GVKEMLRCTTSGKWNVGVQAAVCKDVEA---PQINCP 570
           G    + CTTSG+W+       CK + +   P + CP
Sbjct: 610 GPNN-VECTTSGRWS--ATPPTCKGIASLPTPGVQCP 643



 Score =  106 bits (264), Expect = 5e-22
 Identities = 64/232 (27%), Positives = 110/232 (47%), Gaps = 25/232 (10%)

Query: 360 CVCREGYRASGQTCELVH-CPALKPPENGYFIQNTC-----NNHFNAACGVRCHPGFDLV 413
           C C  G+   G  CE V  C  L+ P++   +   C     N  FN+ C   C  G+ + 
Sbjct: 183 CSCYPGFY--GPECEYVRECGELELPQH---VLMNCSHPLGNFSFNSQCSFHCTDGYQVN 237

Query: 414 GSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISC--STREMLYKTTCLVACDEGYR 471
           G S + CL +G+W+     C    CP L+ P+ G+++C  S +   ++++C  +C+EG+ 
Sbjct: 238 GPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFA 297

Query: 472 LEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSC 529
           L G + + C  +  W  P P C    C   + P +      +C      F  G+ C   C
Sbjct: 298 LVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSE---GTMDCVHPLTAFAYGSSCKFEC 354

Query: 530 RQGFILSGVKEMLRCTTSGKWNVGV---QAAVCKDVEAP---QINCPKDIEA 575
           + G+ + G+ +MLRC  SG W+  +   +A  C+ +E+P    ++C   + A
Sbjct: 355 QPGYRVRGL-DMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRA 405



 Score = 96.7 bits (239), Expect = 4e-19
 Identities = 84/317 (26%), Positives = 123/317 (38%), Gaps = 49/317 (15%)

Query: 265 PSGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACP 324
           P G+F    +  CS+ C+EG                   +C+    +    +  EC A P
Sbjct: 464 PFGAFRYQSV--CSFTCNEGLLLVG----------ASVLQCLATGNW--NSVPPECQAIP 509

Query: 325 --------SGTY---KPEGSPGGISSCIPCPDENHTSPPGSTSPE--DCVCREGYRASGQ 371
                   +GT    +P GS    S+C    DE ++     + PE  DC     +  S  
Sbjct: 510 CTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSL----SGPERLDCTRSGRWTDSPP 565

Query: 372 TCELVHCPALKPPENGYFIQNTCNNHFN--AACGVRCHPGFDLVGSSIILCLPNGLWSGS 429
            CE + CP L  PE G    +     FN  + C   C  GF L G + + C  +G WS +
Sbjct: 566 MCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSAT 625

Query: 430 ESYCRVRT--------CPHLRQPKHGHISCSTREMLY--KTTCLVACDEGYRLEGSDKLT 479
              C+           CP L  P  G + C      +   TTC   C+ G+ L G   L+
Sbjct: 626 PPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLS 685

Query: 480 CQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQGFILSG 537
           C+ + QW    P C    CS   + K + +   NC      F  G+IC   C +G +L+G
Sbjct: 686 CRPSGQWTAVTPACRAVKCSELHVNKPIAM---NCSNLWGNFSYGSICSFHCLEGQLLNG 742

Query: 538 VKEMLRCTTSGKWNVGV 554
                 C  +G W+  V
Sbjct: 743 -SAQTACQENGHWSTTV 758



 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 70/245 (28%), Positives = 90/245 (36%), Gaps = 47/245 (19%)

Query: 277 CSYLCDEGKDC-------CDRMG----------SCKC----GTHTGHFECICEKGYYGKG 315
           C ++CDEG          C R G          + KC        G  +C   +G +  G
Sbjct: 536 CQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVG 595

Query: 316 LQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCEL 375
                + C +G +K EG         P   E  TS   S +P  C         G     
Sbjct: 596 STCHFS-CDNG-FKLEG---------PNNVECTTSGRWSATPPTCKGIASLPTPG----- 639

Query: 376 VHCPALKPPENGYFIQNTCNNH-----FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSE 430
           V CPAL  P  G      C +H     FN  C   C+ GF L+G S + C P+G W+   
Sbjct: 640 VQCPALTTPGQGTMY---CRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVT 696

Query: 431 SYCRVRTCPHLRQPKHGHISCST--REMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDG 488
             CR   C  L   K   ++CS       Y + C   C EG  L GS +  CQ N  W  
Sbjct: 697 PACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWST 756

Query: 489 PEPRC 493
             P C
Sbjct: 757 TVPTC 761



 Score = 43.1 bits (100), Expect = 0.005
 Identities = 15/39 (38%), Positives = 21/39 (53%)

Query: 1387 CQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTG 1425
            CQ   C  Q  C++ + +Y+C C PGF G  CE  +  G
Sbjct: 163  CQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECG 201



 Score = 42.4 bits (98), Expect = 0.008
 Identities = 40/162 (24%), Positives = 61/162 (37%), Gaps = 27/162 (16%)

Query: 1273 CSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAV--CEDQVGGFL 1330
            C    C  +G C++ +  Y C+C  GF G  CE  V EC       + +  C   +G F 
Sbjct: 163  CQDMSCSKQGECLETIGNYTCSCYPGFYGPECE-YVRECGELELPQHVLMNCSHPLGNF- 220

Query: 1331 CKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFT-------GSHC-EL 1382
                     ++C        S  C +G    +G +   CL +  +T        + C  L
Sbjct: 221  ------SFNSQC--------SFHCTDGYQV-NGPSKLECLASGIWTNKPPQCLAAQCPPL 265

Query: 1383 NINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQST 1424
             I E  +  C + A      +S S  C+ GF+    E  Q T
Sbjct: 266  KIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCT 307



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 47/216 (21%), Positives = 73/216 (33%), Gaps = 57/216 (26%)

Query: 1235 CSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVD-----GVA 1289
            C  + C   G C + +G + C C  G+ G  C E + EC     L + + ++     G  
Sbjct: 163  CQDMSCSKQGECLETIGNYTCSCYPGFYGPEC-EYVRECGELE-LPQHVLMNCSHPLGNF 220

Query: 1290 GYRCTCVKGFVGLHCET--EVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVD 1347
             +   C       HC    +VN      CL + +  ++        PP  L  +C     
Sbjct: 221  SFNSQC-----SFHCTDGYQVNGPSKLECLASGIWTNK--------PPQCLAAQCPP--- 264

Query: 1348 ECLSQPCKNGATCKDGANSF----------------------RCLCAAGFTGSHCELNIN 1385
              L  P +   TC   A +F                      +C  +  +T         
Sbjct: 265  --LKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAV 322

Query: 1386 ECQ--SNPCRNQATCVDELNSY----SCK--CQPGF 1413
            +CQ    P      CV  L ++    SCK  CQPG+
Sbjct: 323  QCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGY 358



 Score = 32.7 bits (73), Expect = 6.6
 Identities = 49/188 (26%), Positives = 63/188 (33%), Gaps = 48/188 (25%)

Query: 286 DCCDRMGSCKCGTHTGHFECICEKGYYGKGLQ-YECTACPSGTYKPEGSPGGISSCIP-- 342
           DC D  G    G+ T HF C  + G+  +G    ECT     +  P    G  S   P  
Sbjct: 584 DCSDTRGEFNVGS-TCHFSC--DNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGV 640

Query: 343 -CPD-----------ENHTSPPGSTSPEDCVCREGY----------RASGQ------TCE 374
            CP             +H    G  +     C  G+          R SGQ       C 
Sbjct: 641 QCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACR 700

Query: 375 LVHCPAL---KPPENGYFIQNTCNN-----HFNAACGVRCHPGFDLVGSSIILCLPNGLW 426
            V C  L   KP      I   C+N      + + C   C  G  L GS+   C  NG W
Sbjct: 701 AVKCSELHVNKP------IAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHW 754

Query: 427 SGSESYCR 434
           S +   C+
Sbjct: 755 STTVPTCQ 762


>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
          Length = 1406

 Score =  251 bits (640), Expect = 1e-65
 Identities = 109/227 (48%), Positives = 138/227 (60%), Gaps = 3/227 (1%)

Query: 1197 CFFNPCHNSGTCQQLG--RGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
            CF NPC  S TC      R ++C CP GY+G  CET I  C    C + G+C       +
Sbjct: 74   CFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPV 133

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
            C CP+GY G+ CE + +EC+SSPC N  +C DG+ GY C CV G+ G HC+ EV+EC S+
Sbjct: 134  CICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASD 193

Query: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
            PC N A C +++G + C CP  + G  C   +DEC SQPC NGATC+D   ++ C CA G
Sbjct: 194  PCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPG 253

Query: 1375 FTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQ-PGFSGKRCET 1420
            F G HCELN +EC S PC +   CVD  N YSC C   GF+G  CET
Sbjct: 254  FLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCET 300



 Score =  236 bits (603), Expect = 2e-61
 Identities = 132/390 (33%), Positives = 188/390 (48%), Gaps = 66/390 (16%)

Query: 1196 ECFFNPCHNSGTC-QQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
            EC  +PC N  TC  ++GR Y C+CP  Y+G+ CE +IDEC   PCLN   C+D +G + 
Sbjct: 189  ECASDPCKNEATCLNEIGR-YTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYF 247

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCV-KGFVGLHCETEVNECQS 1313
            C+C  G+ G  CE N +EC+S PCL+ G+CVDG   Y C C   GF G HCET +  C S
Sbjct: 248  CDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWS 307

Query: 1314 NPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKD----------- 1362
             PC NNA CED V  + C C PG+ G +C  +++EC S PC++   C +           
Sbjct: 308  KPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRIT 367

Query: 1363 ---------GANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKC---- 1409
                      A+ + C+C  GFTG HCE ++NEC SNPC+N  TC +   +Y+C C    
Sbjct: 368  GLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDN 427

Query: 1410 --QPGFSGKRCE------TEQ---STGFNLDFEVSGIYGYVML--DGMLPSLHALTCT-- 1454
              +  + G+ C       T Q   + G  +     G +G+  L   G   SL  +  T  
Sbjct: 428  LSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTLS 487

Query: 1455 ------FWMKSSDDMNYGTPISYAVDNGSDNTL----------------LLTDYNGWVLY 1492
                   W+KS      G+  + A+   +   +                LL+ Y    + 
Sbjct: 488  FEGDGFLWVKSGSVTTKGSVCNIALRFQTVQPMALLLFRSNRDVFVKLELLSGYIHLSIQ 547

Query: 1493 VNGREKITNCPSVN--DGRWHHIAITWTSA 1520
            VN + K+    S N  DG WH + + +  A
Sbjct: 548  VNNQSKVLLFISHNTSDGEWHFVEVIFAEA 577



 Score =  230 bits (586), Expect = 2e-59
 Identities = 100/247 (40%), Positives = 133/247 (53%), Gaps = 21/247 (8%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            EC  +PC N   CQ    GY C C  GY G  C+ ++DEC+  PC N   C + +G + C
Sbjct: 151  ECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTC 210

Query: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP 1315
             CP  Y+G  CE  I+EC S PCLN   C D +  Y C C  GF+G HCE   +EC S P
Sbjct: 211  ICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQP 270

Query: 1316 CLNNAVCEDQVGGFLCKCP-PGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
            CL+  +C D    + C C   GF GT C   +  C S+PC N ATC+D  +++ C C  G
Sbjct: 271  CLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPG 330

Query: 1375 FTGSHCELNINECQSNPCRNQATCVD--------------------ELNSYSCKCQPGFS 1414
            +TG+ CE+++NEC SNPC++   CV+                    E + Y C CQPGF+
Sbjct: 331  YTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFT 390

Query: 1415 GKRCETE 1421
            G  CE +
Sbjct: 391  GIHCEED 397



 Score =  182 bits (463), Expect = 4e-45
 Identities = 78/197 (39%), Positives = 114/197 (57%), Gaps = 8/197 (4%)

Query: 1232 IDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGY 1291
            ++ C+  PCL+ G C+D+   + C CP G++G+ CE NI+EC S+PC++ G C D VA Y
Sbjct: 1140 LNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSDRVAAY 1198

Query: 1292 RCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNV----- 1346
             CTC  G+ G++CE +++ CQS+ C N A C     G+ C C   F G  C ++      
Sbjct: 1199 HCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTV 1258

Query: 1347 --DECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNS 1404
              +E  +  C NG  C +     +C+C  GFTG  CE +I+EC S+PC N   C D LN 
Sbjct: 1259 CGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNK 1318

Query: 1405 YSCKCQPGFSGKRCETE 1421
            + C C   F+G+RCE +
Sbjct: 1319 FQCLCDVAFAGERCEVD 1335



 Score =  177 bits (449), Expect = 2e-43
 Identities = 127/395 (32%), Positives = 171/395 (43%), Gaps = 52/395 (13%)

Query: 1032 CKLCPSGMYTEYIHSRNISDC-KAQCKQGTYSYSG--LETCESCPLGTYQPKF---GSRS 1085
            CK CP G Y+  I    I  C K  C+ G   +       C  CP G Y  +F       
Sbjct: 96   CK-CPPG-YSGTICETTIGSCGKNSCQHGGICHQDPIYPVC-ICPAG-YAGRFCEIDHDE 151

Query: 1086 CLSCP-ENTSTVKRGAVNISACGVPCPEGKFSRSGLMPC--HPCPRDYYQPNAGKAFCLA 1142
            C S P +N +  + G    S   VP  +G+     +  C   PC  +    N    +   
Sbjct: 152  CASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTCI 211

Query: 1143 CPFYGTTPFAGSRSITECSSF----SSTFSAAEESVVPPASLGHIKKRHEISSQVFHECF 1198
            CP +  +       I EC S      +T   A  +     + G +    E+++    EC 
Sbjct: 212  CP-HNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTD---ECA 267

Query: 1199 FNPCHNSGTCQQLGRGYVCLCP-LGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICEC 1257
              PC + G C      Y C C   G+TG  CET +  C   PC NN  C+D V  + C C
Sbjct: 268  SQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHC 327

Query: 1258 PSGYTGQRCEENINECSSSPCLNKGICVD--------------------GVAGYRCTCVK 1297
              GYTG +CE ++NEC+S+PC + G CV+                      +GY C C  
Sbjct: 328  WPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQP 387

Query: 1298 GFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFL------GTRCGKNVDECLS 1351
            GF G+HCE +VNEC SNPC N   CE+  G + C CP   L      G  C   +  C  
Sbjct: 388  GFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTH 447

Query: 1352 QPCKNGATC----KDGANSFRCLCAAGFTGSHCEL 1382
            Q C N  TC    +DG + F CLC +G+TGS CE+
Sbjct: 448  QQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEI 482



 Score =  171 bits (434), Expect = 9e-42
 Identities = 78/195 (40%), Positives = 99/195 (50%), Gaps = 8/195 (4%)

Query: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICE 1256
            C  NPC + G C+ +   Y C CPLG++G  CE +IDEC   PC++ G C D V  + C 
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSDRVAAYHCT 1201

Query: 1257 CPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEV-------N 1309
            C  GYTG  CE +I+ C S  C N   C+    GY C C   F G  C           N
Sbjct: 1202 CEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGN 1261

Query: 1310 ECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRC 1369
            E  +  C N   C +      C C PGF G  C K++DEC S PC NG  C+D  N F+C
Sbjct: 1262 EKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQC 1321

Query: 1370 LCAAGFTGSHCELNI 1384
            LC   F G  CE+++
Sbjct: 1322 LCDVAFAGERCEVDL 1336



 Score =  169 bits (427), Expect = 6e-41
 Identities = 72/198 (36%), Positives = 104/198 (52%), Gaps = 4/198 (2%)

Query: 1228 CETDIDECSPLPCLNNGVCKDLVGEFICECP--SGYTGQRCEENINECSSSPCLNKGICV 1285
            C  +   C    C NN  CKD   +  C C   +    + C+   + C S+PC     CV
Sbjct: 27   CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCV 86

Query: 1286 D--GVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCG 1343
            +  G   + C C  G+ G  CET +  C  N C +  +C       +C CP G+ G  C 
Sbjct: 87   NTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE 146

Query: 1344 KNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELN 1403
             + DEC S PC+NGA C+DG + + C C  G+ G HC+L ++EC S+PC+N+ATC++E+ 
Sbjct: 147  IDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIG 206

Query: 1404 SYSCKCQPGFSGKRCETE 1421
             Y+C C   +SG  CE E
Sbjct: 207  RYTCICPHNYSGVNCELE 224



 Score =  132 bits (333), Expect = 5e-30
 Identities = 109/387 (28%), Positives = 153/387 (39%), Gaps = 85/387 (21%)

Query: 1017 SCRIGSYQDEEGQLECKLCPSGM---YTEYIHSRNISD-CK--AQCKQGTYSYS------ 1064
            SC+ G    ++      +CP+G    + E  H    S  C+  A C+ G   YS      
Sbjct: 118  SCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPG 177

Query: 1065 --------GLETCESCPL---GTYQPKFGSRSCLSCPENTSTVKRGAVNISAC-GVPCPE 1112
                     ++ C S P     T   + G  +C+ CP N S V    + I  C   PC  
Sbjct: 178  YQGRHCDLEVDECASDPCKNEATCLNEIGRYTCI-CPHNYSGV-NCELEIDECWSQPCLN 235

Query: 1113 GKFSRS--GLMPCHPCP---RDYYQPNAGKAFCLACPFYGTTPFAGSRSITEC--SSFSS 1165
            G   +   G   C   P    D+ + N  +     C   G      +R    C  S F+ 
Sbjct: 236  GATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTG 295

Query: 1166 TFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTG 1225
            T     E+++P                    C+  PCHN+ TC+     Y C C  GYTG
Sbjct: 296  THC---ETLMP-------------------LCWSKPCHNNATCEDSVDNYTCHCWPGYTG 333

Query: 1226 LKCETDIDECSPLPCLNNGVCKDLVGE--------------------FICECPSGYTGQR 1265
             +CE D++EC+  PC +NG C +L  E                    ++C C  G+TG  
Sbjct: 334  AQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIH 393

Query: 1266 CEENINECSSSPCLNKGICVDGVAGYRCTCV------KGFVGLHCETEVNECQSNPCLNN 1319
            CEE++NECSS+PC N G C +    Y C C         + G  C   +  C    CLNN
Sbjct: 394  CEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNN 453

Query: 1320 AVC----EDQVGGFLCKCPPGFLGTRC 1342
              C    +D   GF C CP G+ G+ C
Sbjct: 454  GTCIPHFQDGQHGFSCLCPSGYTGSLC 480



 Score =  124 bits (310), Expect = 2e-27
 Identities = 51/112 (45%), Positives = 68/112 (60%), Gaps = 1/112 (0%)

Query: 1307 EVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANS 1366
            ++N C SNPCL+   CED    + C CP G+ G  C  N+DEC S PC +G  C D   +
Sbjct: 1139 QLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHG-NCSDRVAA 1197

Query: 1367 FRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
            + C C  G+TG +CE++I+ CQS+ C N ATC+   N YSC C   F+GK C
Sbjct: 1198 YHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFC 1249



 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 42/107 (39%), Positives = 54/107 (50%), Gaps = 14/107 (13%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPI--CIL-PCLNGGRC--VAPYQCDCPPGW 3526
            PC +GG C+   +   CSCP GW G+ CE  I  C   PC++G     VA Y C C PG+
Sbjct: 1147 PCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAYHCTCEPGY 1206

Query: 3527 TGSRCHTAV--CQS-PCLNGGKCVRPNR---CHCLSSWTGHNCSRKR 3567
            TG  C   +  CQS  C NG  C+       C C  ++TG  C + R
Sbjct: 1207 TGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSR 1253



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 49/189 (25%), Positives = 80/189 (42%), Gaps = 23/189 (12%)

Query: 1347 DECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYS 1406
            + C S PC NG  C    + F C C A  +G  CE  +  C  +PC + A C   L  + 
Sbjct: 889  NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947

Query: 1407 CKCQPGFSGKRCETEQSTGFNLDFEVSGI-YGYVMLDGMLPSLHALTCTFWMKSSDDMNY 1465
            C     F+G+  +    +  N+  E++ I +G+   D  +  LHA       K  + +N 
Sbjct: 948  CIANAVFNGQSGQILFRSNGNITRELTNITFGFRTRDANVIILHA------EKEPEFLNI 1001

Query: 1466 GTPISYAVDNGSDNTLLLTDYNGWVLYVNGREKITNCPSVNDGRWHHIAITWT---SANG 1522
                        D+ L     +G   Y+     +T+  SVNDG WH + ++ T   S   
Sbjct: 1002 SI---------QDSRLFFQLQSGNSFYM---LSLTSLQSVNDGTWHEVTLSMTDPLSQTS 1049

Query: 1523 IWKVYIDGK 1531
             W++ +D +
Sbjct: 1050 RWQMEVDNE 1058



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 38/103 (36%), Positives = 48/103 (46%), Gaps = 15/103 (14%)

Query: 3476 CQNGGICQRPN---ACSCPEGWMGRLCE---EPICILPCLNGGRC---VAPYQCDCPPGW 3526
            CQ+GGIC +      C CP G+ GR CE   +     PC NG  C   +  Y C C PG+
Sbjct: 119  CQHGGICHQDPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGY 178

Query: 3527 TGSRCHTAV--CQS-PCLNGGKCVRP---NRCHCLSSWTGHNC 3563
             G  C   V  C S PC N   C+       C C  +++G NC
Sbjct: 179  QGRHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNC 221



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 43/105 (40%), Positives = 52/105 (49%), Gaps = 16/105 (15%)

Query: 3475 PCQNGGICQRP---NACSCPEGWMGRLCEEPI---CILPCLNGGRC---VAPYQCDCPPG 3525
            PC+N   C        C CP  + G  CE  I      PCLNG  C   +  Y CDC PG
Sbjct: 194  PCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPG 253

Query: 3526 WTGSRC--HTAVCQS-PCLNGGKCV-RPNR--CHCL-SSWTGHNC 3563
            + G  C  +T  C S PCL+GG CV   NR  C+C  S +TG +C
Sbjct: 254  FLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHC 298



 Score = 62.8 bits (151), Expect = 6e-09
 Identities = 40/105 (38%), Positives = 49/105 (46%), Gaps = 16/105 (15%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCE---EPICILPCLNGGRCVAP---YQCDCP-P 3524
            PC NG  CQ       C C  G++G  CE   +     PCL+GG CV     Y C+C   
Sbjct: 232  PCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGS 291

Query: 3525 GWTGSRCHTAV--CQS-PCLNGGKC---VRPNRCHCLSSWTGHNC 3563
            G+TG+ C T +  C S PC N   C   V    CHC   +TG  C
Sbjct: 292  GFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQC 336



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 33/86 (38%), Positives = 46/86 (53%), Gaps = 13/86 (15%)

Query: 3475 PCQNGGIC---QRPNACSCP-EGWMGRLCEE--PIC-ILPCLNGGRC---VAPYQCDCPP 3524
            PC +GG+C   +   +C+C   G+ G  CE   P+C   PC N   C   V  Y C C P
Sbjct: 270  PCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWP 329

Query: 3525 GWTGSRCHTAV--CQS-PCLNGGKCV 3547
            G+TG++C   +  C S PC + G+CV
Sbjct: 330  GYTGAQCEIDLNECNSNPCQSNGECV 355



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 34/110 (30%), Positives = 47/110 (42%), Gaps = 22/110 (20%)

Query: 3476 CQNGGIC---QRPNACSCPEGWMGRLCEEP-----IC-----ILPCLNGGRCV---APYQ 3519
            C NG  C       +C C   + G+ C +      +C      L C NGG C       +
Sbjct: 1223 CANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELK 1282

Query: 3520 CDCPPGWTGSRCHTAV--CQS-PCLNGGKC---VRPNRCHCLSSWTGHNC 3563
            C C PG+TG  C   +  C S PC+NGG C   +   +C C  ++ G  C
Sbjct: 1283 CMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERC 1332



 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 1/69 (1%)

Query: 1233 DECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYR 1292
            + C   PC N GVC     +F C CP+  +G+ CEE +  C  SPC +   C   + G+ 
Sbjct: 889  NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEE-VQWCGFSPCPHGAQCQPVLQGFE 947

Query: 1293 CTCVKGFVG 1301
            C     F G
Sbjct: 948  CIANAVFNG 956



 Score = 48.9 bits (115), Expect = 9e-05
 Identities = 22/70 (31%), Positives = 33/70 (47%), Gaps = 1/70 (1%)

Query: 1195 HECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
            + C  NPCHN G C      + C CP   +G  CE ++  C   PC +   C+ ++  F 
Sbjct: 889  NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947

Query: 1255 CECPSGYTGQ 1264
            C   + + GQ
Sbjct: 948  CIANAVFNGQ 957



 Score = 48.1 bits (113), Expect = 2e-04
 Identities = 42/151 (27%), Positives = 54/151 (35%), Gaps = 39/151 (25%)

Query: 3443 YSGYMLEGFLRSVCLENGTWTSPPICRAVCRF----PCQNGGICQRP---NACSCPEGWM 3495
            + G  ++G  R  C   G+  +   C  +       PC N   C+       C C  G+ 
Sbjct: 273  HGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYT 332

Query: 3496 GRLCEEPICIL---PCLNGGRCV-----------------------APYQCDCPPGWTGS 3529
            G  CE  +      PC + G CV                       + Y C C PG+TG 
Sbjct: 333  GAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGI 392

Query: 3530 RCHTAV--CQS-PCLNGGKCVR-PNR--CHC 3554
             C   V  C S PC NGG C   P    CHC
Sbjct: 393  HCEEDVNECSSNPCQNGGTCENLPGNYTCHC 423



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 19/38 (50%), Positives = 23/38 (60%)

Query: 1382 LNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
            L +N C SNPC +   C D  +SY C C  G+SGK CE
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCE 1175



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 23/61 (37%), Positives = 31/61 (50%), Gaps = 1/61 (1%)

Query: 1271 NECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFL 1330
            N C S+PC N G+C      + C+C     G  CE EV  C  +PC + A C+  + GF 
Sbjct: 889  NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947

Query: 1331 C 1331
            C
Sbjct: 948  C 948



 Score = 46.6 bits (109), Expect = 4e-04
 Identities = 31/107 (28%), Positives = 49/107 (45%), Gaps = 19/107 (17%)

Query: 3476 CQNGGICQ---RPNACSCPE--GWMGRLCE---EPICILPCLNGGRCV-----APYQCDC 3522
            CQN   C+   + N CSC +    + + C+   +P    PC     CV       + C C
Sbjct: 39   CQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERSFLCKC 98

Query: 3523 PPGWTGSRCHTAV--C-QSPCLNGGKCVRP---NRCHCLSSWTGHNC 3563
            PPG++G+ C T +  C ++ C +GG C +      C C + + G  C
Sbjct: 99   PPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFC 145



 Score = 45.8 bits (107), Expect = 8e-04
 Identities = 30/83 (36%), Positives = 37/83 (44%), Gaps = 19/83 (22%)

Query: 3475 PCQNGGICQR---PNACSCPEG------WMGRLCEEPI--CI-LPCLNGGRCVAPYQ--- 3519
            PCQNGG C+       C CP        + GR C + +  C    CLN G C+  +Q   
Sbjct: 405  PCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQ 464

Query: 3520 ----CDCPPGWTGSRCHTAVCQS 3538
                C CP G+TGS C  A   S
Sbjct: 465  HGFSCLCPSGYTGSLCEIATTLS 487



 Score = 43.1 bits (100), Expect = 0.005
 Identities = 16/37 (43%), Positives = 22/37 (59%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDI 1232
            EC  +PC N G CQ L   + CLC + + G +CE D+
Sbjct: 1300 ECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDL 1336



 Score = 37.4 bits (85), Expect = 0.27
 Identities = 54/222 (24%), Positives = 79/222 (35%), Gaps = 39/222 (17%)

Query: 1716 CNNGYYLLGD-SRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVP 1774
            C N    L +  R  C    +++GV+   L++DEC     C   A+C +  G+Y C C P
Sbjct: 195  CKNEATCLNEIGRYTCICPHNYSGVNCE-LEIDECW-SQPCLNGATCQDALGAYFCDCAP 252

Query: 1775 PYTGDGKNC-AEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESG 1833
             + GD  +C     +C +      G        V  E  +SC             C  SG
Sbjct: 253  GFLGD--HCELNTDECASQPCLHGG------LCVDGENRYSC------------NCTGSG 292

Query: 1834 ----EWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLA 1889
                    L+P C +  C   A  E+              T  C  GYT A  +      
Sbjct: 293  FTGTHCETLMPLCWSKPCHNNATCEDSV---------DNYTCHCWPGYTGAQCEIDLNEC 343

Query: 1890 NSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSC 1931
            NS+   S   C  V+ SS +       + S  +Y   + Y C
Sbjct: 344  NSNPCQSNGEC--VELSSEKQYGRITGLPSSFSYHEASGYVC 383



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 18/45 (40%), Positives = 23/45 (51%), Gaps = 5/45 (11%)

Query: 3475 PCQNGGICQR---PNACSCPEGWMGRLCEEP--ICILPCLNGGRC 3514
            PC NGG+C       +CSCP    G+ CEE       PC +G +C
Sbjct: 895  PCHNGGVCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQC 939



 Score = 36.6 bits (83), Expect = 0.46
 Identities = 13/39 (33%), Positives = 20/39 (51%)

Query: 1387 CQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTG 1425
            C+S PC+++  C++   SY C C   + G  C  E   G
Sbjct: 676  CESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAG 714



 Score = 35.8 bits (81), Expect = 0.78
 Identities = 48/205 (23%), Positives = 72/205 (35%), Gaps = 54/205 (26%)

Query: 296 CGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENH----TSP 351
           C     ++ C C  GY G   + +   C S   +  G       C+    E      T  
Sbjct: 316 CEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNG------ECVELSSEKQYGRITGL 369

Query: 352 PGSTSPED-----CVCREGYRASGQTCEL-VHCPALKPPENGYFIQNTCNNHFNAACGVR 405
           P S S  +     C+C+ G+  +G  CE  V+  +  P +NG   +N   N+        
Sbjct: 370 PSSFSYHEASGYVCICQPGF--TGIHCEEDVNECSSNPCQNGGTCENLPGNY-------T 420

Query: 406 CHPGFD---------------LVGSSIILCLPNGLWSGSESYCRVRTC-PHLRQPKHGHI 449
           CH  FD               L+G +   CL NG            TC PH +  +HG  
Sbjct: 421 CHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNG------------TCIPHFQDGQHG-F 467

Query: 450 SCSTREMLYKTTCLVACDEGYRLEG 474
           SC        + C +A    +  +G
Sbjct: 468 SCLCPSGYTGSLCEIATTLSFEGDG 492



 Score = 34.7 bits (78), Expect = 1.7
 Identities = 14/51 (27%), Positives = 27/51 (52%), Gaps = 2/51 (3%)

Query: 1730 CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDG--SYICSCVPPYTG 1778
            C+ + + N +   C ++ +    + C   A+C+N  G  S++C C P Y+G
Sbjct: 54   CSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERSFLCKCPPGYSG 104



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 40/150 (26%), Positives = 55/150 (36%), Gaps = 33/150 (22%)

Query: 284 GKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQY---ECTA--CPSGTYKPEGSPGGIS 338
           GK+ C   G C       +  CIC  GY G+  +    EC +  C +G    +G  G   
Sbjct: 115 GKNSCQHGGICH--QDPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSC 172

Query: 339 SCIP------C----------PDENHTSPPGSTSPEDCVCREGYRASGQTCELV--HCPA 380
            C+P      C          P +N  +         C+C   Y  SG  CEL    C +
Sbjct: 173 FCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNY--SGVNCELEIDECWS 230

Query: 381 LKPPENGYFIQNTCNNHFNAACGVRCHPGF 410
            +P  NG   Q+    +F       C PGF
Sbjct: 231 -QPCLNGATCQDALGAYF-----CDCAPGF 254



 Score = 33.5 bits (75), Expect = 3.9
 Identities = 13/32 (40%), Positives = 15/32 (46%)

Query: 1378 SHCELNINECQSNPCRNQATCVDELNSYSCKC 1409
            S C  N   C SN C+N +TC D      C C
Sbjct: 25   SFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSC 56



 Score = 33.5 bits (75), Expect = 3.9
 Identities = 12/35 (34%), Positives = 20/35 (57%)

Query: 1273 CSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETE 1307
            C S PC ++G C++    Y+C C + + G +C  E
Sbjct: 676  CESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLRE 710



 Score = 33.1 bits (74), Expect = 5.1
 Identities = 18/51 (35%), Positives = 23/51 (45%), Gaps = 3/51 (5%)

Query: 1733 NGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNC 1783
            +GS   V   C+  D C     C     C+N+  SY C C  PY  +G NC
Sbjct: 660  SGSSLNVKAGCVRKDWCE-SQPCQSRGRCINLWLSYQCDCHRPY--EGPNC 707



 Score = 32.3 bits (72), Expect = 8.6
 Identities = 16/35 (45%), Positives = 18/35 (51%), Gaps = 1/35 (2%)

Query: 1744 LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778
            +D DECA  S C   A C +    Y C CVP Y G
Sbjct: 147  IDHDECA-SSPCQNGAVCQDGIDGYSCFCVPGYQG 180


>gi|4557679 jagged 1 precursor [Homo sapiens]
          Length = 1218

 Score =  248 bits (632), Expect = 1e-64
 Identities = 98/224 (43%), Positives = 142/224 (63%), Gaps = 1/224 (0%)

Query: 1195 HECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
            H C  +PCHN G+C++   G+ C C  G+TG  C T+ID+CSP  C + G C+DLV  F 
Sbjct: 338  HACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFK 397

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
            C CP  +TG+ C+ + NEC + PC+N   C + +A Y C C+ G++G +C+  +N+C   
Sbjct: 398  CVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQ 457

Query: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
             C N+A C D V G+ C CPPG+ G  C +++DEC S PC NG  C++  N F+CLC  G
Sbjct: 458  -CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTG 516

Query: 1375 FTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
            F+G+ C+L+I+ C+ NPC+N A C +  + Y CKC   + GK C
Sbjct: 517  FSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNC 560



 Score =  231 bits (590), Expect = 7e-60
 Identities = 139/410 (33%), Positives = 180/410 (43%), Gaps = 41/410 (10%)

Query: 1048 NISDCKAQCKQ--------------------GTYSYSGLETCESCPL---GTYQPKFGSR 1084
            NI+DC  QC+                     G +    ++ C S P    G  Q +    
Sbjct: 450  NINDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRF 509

Query: 1085 SCLSCPENTSTVKRGAVNISACGV-PCPEGK--FSRSGLMPCHPCPRDYYQPNAG--KAF 1139
             CL CP   S      ++I  C   PC  G   ++R+    C  CP DY   N    K  
Sbjct: 510  QCL-CPTGFSG-NLCQLDIDYCEPNPCQNGAQCYNRASDYFCK-CPEDYEGKNCSHLKDH 566

Query: 1140 CLACP---FYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKK--RHEISSQVF 1194
            C   P       T    S    E   + S+            S G          +    
Sbjct: 567  CRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYC 626

Query: 1195 HE----CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLV 1250
            HE    C  NPC N GTC      Y C+C  G+ G  CET+I++CS  PC N G C+DLV
Sbjct: 627  HENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLV 686

Query: 1251 GEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNE 1310
             +F C+C +G+ G+ C    ++C  + C N G C D    ++C C  G+ G  C    N 
Sbjct: 687  NDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNS 746

Query: 1311 -CQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRC 1369
             C  NPC N   C      F C C  G+ G  C +N ++C   PC N  TC DG N +RC
Sbjct: 747  SCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRC 806

Query: 1370 LCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
             CA GF G  C +NINECQS+PC   ATCVDE+N Y C C PG SG +C+
Sbjct: 807  ECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ 856



 Score =  224 bits (570), Expect = 2e-57
 Identities = 94/222 (42%), Positives = 131/222 (59%), Gaps = 2/222 (0%)

Query: 1201 PCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPS 1259
            PC N GTC   G   Y C CP GY+G  CE     C   PC N G CK+    F CEC  
Sbjct: 305  PCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSP 364

Query: 1260 GYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNN 1319
            G+TG  C  NI++CS + C + G C D V G++C C   + G  C+ + NEC++ PC+N 
Sbjct: 365  GWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNA 424

Query: 1320 AVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSH 1379
              C++ +  + C C PG++G  C  N+++CL Q C+N A+C+D  N +RC+C  G+ G H
Sbjct: 425  KSCKNLIASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDH 483

Query: 1380 CELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
            CE +I+EC SNPC N   C +E+N + C C  GFSG  C+ +
Sbjct: 484  CERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLD 525



 Score =  210 bits (535), Expect = 2e-53
 Identities = 123/386 (31%), Positives = 176/386 (45%), Gaps = 60/386 (15%)

Query: 1075 GTYQPKFGSRSCLSCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPN 1134
            GT+QP     +C     NT   K            CPEG    +  +  H C  D    N
Sbjct: 301  GTHQPCLNGGTC----SNTGPDKYQC--------SCPEGYSGPNCEIAEHACLSDPCH-N 347

Query: 1135 AGKAFCLACPFY-----GTTPFAGSRSITECSSFSSTFSAAEESVV-------PPASLGH 1182
             G     +  F      G T    S +I +CS  + +     + +V       PP   G 
Sbjct: 348  RGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTG- 406

Query: 1183 IKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLN 1242
              K  ++ +   +EC   PC N+ +C+ L   Y C C  G+ G  C+ +I++C    C N
Sbjct: 407  --KTCQLDA---NECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLG-QCQN 460

Query: 1243 NGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGL 1302
            +  C+DLV  + C CP GY G  CE +I+EC+S+PCLN G C + +  ++C C  GF G 
Sbjct: 461  DASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGN 520

Query: 1303 HCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCK------- 1355
             C+ +++ C+ NPC N A C ++   + CKCP  + G  C    D C + PC+       
Sbjct: 521  LCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTV 580

Query: 1356 ---------------------NGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRN 1394
                                 +G         F C C  GFTG++C  NIN+C+SNPCRN
Sbjct: 581  AMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRN 640

Query: 1395 QATCVDELNSYSCKCQPGFSGKRCET 1420
              TC+D +NSY C C  G+ G  CET
Sbjct: 641  GGTCIDGVNSYKCICSDGWEGAYCET 666



 Score =  197 bits (501), Expect = 2e-49
 Identities = 86/257 (33%), Positives = 120/257 (46%), Gaps = 28/257 (10%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            EC  NPC N G CQ     + CLCP G++G  C+ DID C P PC N   C +   ++ C
Sbjct: 490  ECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFC 549

Query: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVDGVAG------------------------- 1290
            +CP  Y G+ C    + C ++PC     C   +A                          
Sbjct: 550  KCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQS 609

Query: 1291 ---YRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVD 1347
               + C C KGF G +C   +N+C+SNPC N   C D V  + C C  G+ G  C  N++
Sbjct: 610  GGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNIN 669

Query: 1348 ECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSC 1407
            +C   PC NG TC+D  N F C C  G+ G  C    ++C    C N  TC DE +++ C
Sbjct: 670  DCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKC 729

Query: 1408 KCQPGFSGKRCETEQST 1424
             C  G+ G  C   +++
Sbjct: 730  MCPGGWEGTTCNIARNS 746



 Score =  179 bits (455), Expect = 3e-44
 Identities = 81/216 (37%), Positives = 125/216 (57%), Gaps = 12/216 (5%)

Query: 1206 GTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQR 1265
            G+C+  G    C C  G+ GL C    D+C P P   +G+C +    + C C + + GQ 
Sbjct: 243  GSCKLPGD---CRCQYGWQGLYC----DKCIPHPGCVHGICNE---PWQCLCETNWGGQL 292

Query: 1266 CEENINECSS-SPCLNKGICVD-GVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCE 1323
            C++++N C +  PCLN G C + G   Y+C+C +G+ G +CE   + C S+PC N   C+
Sbjct: 293  CDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCK 352

Query: 1324 DQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELN 1383
            +   GF C+C PG+ G  C  N+D+C    C +G TC+D  N F+C+C   +TG  C+L+
Sbjct: 353  ETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLD 412

Query: 1384 INECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
             NEC++ PC N  +C + + SY C C PG+ G+ C+
Sbjct: 413  ANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCD 448



 Score = 88.6 bits (218), Expect = 1e-16
 Identities = 89/356 (25%), Positives = 132/356 (37%), Gaps = 45/356 (12%)

Query: 1028 GQLECKLCPSGMYTEYIHSRNISDCKAQ-CKQGTYSYSGLETCESCPLGTYQPKFGSRSC 1086
            G+  C  C  G    Y H  NI+DC++  C+ G     G+ + +      ++  +   + 
Sbjct: 611  GKFTCD-CNKGFTGTYCHE-NINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNI 668

Query: 1087 LSCPEN---TSTVKRGAVNISACGVPCP-EGKFSRSGLMPCHP--CPRDYYQPNAGKAFC 1140
              C +N        R  VN   C      +GK   S    C    C       + G AF 
Sbjct: 669  NDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFK 728

Query: 1141 LACP--FYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRH---EISSQVFH 1195
              CP  + GTT      S    S   +        VV   S   + K      I +Q  +
Sbjct: 729  CMCPGGWEGTTCNIARNS----SCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTN 784

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            +C  +PC+NSGTC      Y C C  G+ G  C  +I+EC   PC     C D +  + C
Sbjct: 785  DCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRC 844

Query: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP 1315
             CP G++G +C+    E S  PC+  G  +               G   + + N CQ   
Sbjct: 845  VCPPGHSGAKCQ----EVSGRPCITMGSVIPD-------------GAKWDDDCNTCQ--- 884

Query: 1316 CLNNAVCEDQV--GGFLCKCPPGFLGTRCGKNV-----DECLSQPCKNGATCKDGA 1364
            CLN  +   +V  G   C    G      G++      D+C   PC     C+  +
Sbjct: 885  CLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSS 940



 Score = 79.7 bits (195), Expect = 5e-14
 Identities = 54/166 (32%), Positives = 70/166 (42%), Gaps = 34/166 (20%)

Query: 3431 HYQYGDMITYSCYSGYMLEGFLRSVCLE-----NGTWTSPPICRAVCRFPCQN------- 3478
            HY        +C  G+M     R++C +     +G+   P  CR  C++  Q        
Sbjct: 209  HYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCR--CQYGWQGLYCDKCI 266

Query: 3479 ------GGICQRPNACSCPEGWMGRLCEEPICIL----PCLNGGRC--VAP--YQCDCPP 3524
                   GIC  P  C C   W G+LC++ +       PCLNGG C    P  YQC CP 
Sbjct: 267  PHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPE 326

Query: 3525 GWTGSRCHTA--VCQS-PCLNGGKCVRPN---RCHCLSSWTGHNCS 3564
            G++G  C  A   C S PC N G C   +    C C   WTG  CS
Sbjct: 327  GYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCS 372



 Score = 77.0 bits (188), Expect = 3e-13
 Identities = 42/105 (40%), Positives = 51/105 (48%), Gaps = 16/105 (15%)

Query: 3475 PCQNGGICQRPNA----CSCPEGWMGRLCE--EPICIL-PCLNGGRCVAP---YQCDCPP 3524
            PC NGG C         CSCPEG+ G  CE  E  C+  PC N G C      ++C+C P
Sbjct: 305  PCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSP 364

Query: 3525 GWTGSRCHTAV---CQSPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
            GWTG  C T +     + C +GG C   V   +C C   WTG  C
Sbjct: 365  GWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTC 409



 Score = 76.3 bits (186), Expect = 5e-13
 Identities = 60/188 (31%), Positives = 71/188 (37%), Gaps = 42/188 (22%)

Query: 3411 CEKISCGPPAHVENAIARGVHY--------------QYGDMITYSCYSGYMLEGFLRSVC 3456
            CE I     A   N    GV Y              Q G   T  C      +GF  + C
Sbjct: 572  CEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCN-----KGFTGTYC 626

Query: 3457 LENGTWTSPPICRAVCRFPCQNGGIC---QRPNACSCPEGWMGRLCEEPI--CIL-PCLN 3510
             EN        C +    PC+NGG C        C C +GW G  CE  I  C   PC N
Sbjct: 627  HENIN-----DCESN---PCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHN 678

Query: 3511 GGRC---VAPYQCDCPPGWTGSRCHTAVCQ---SPCLNGGKCVRPN---RCHCLSSWTGH 3561
            GG C   V  + CDC  GW G  CH+   Q   + C NGG C       +C C   W G 
Sbjct: 679  GGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGT 738

Query: 3562 NCSRKRRT 3569
             C+  R +
Sbjct: 739  TCNIARNS 746



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 41/110 (37%), Positives = 53/110 (48%), Gaps = 19/110 (17%)

Query: 3472 CRFPCQNGGICQ---RPNACSCPEGWMGRLCEEPI---CILPCLNGGRC---VAPYQCDC 3522
            C   CQN   C+       C CP G+ G  CE  I      PCLNGG C   +  +QC C
Sbjct: 454  CLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLC 513

Query: 3523 PPGWTGSRCHTAV--CQ-SPCLNGGKCVRPNR-----CHCLSSWTGHNCS 3564
            P G++G+ C   +  C+ +PC NG +C   NR     C C   + G NCS
Sbjct: 514  PTGFSGNLCQLDIDYCEPNPCQNGAQCY--NRASDYFCKCPEDYEGKNCS 561



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 36/104 (34%), Positives = 44/104 (42%), Gaps = 14/104 (13%)

Query: 3476 CQNGGICQ---RPNACSCPEGWMGRLCE---EPICILPCLNGGRC---VAPYQCDCPPGW 3526
            C +GG CQ       C CP  W G+ C+         PC+N   C   +A Y CDC PGW
Sbjct: 383  CSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGW 442

Query: 3527 TGSRCHTAV--CQSPCLNGGKC---VRPNRCHCLSSWTGHNCSR 3565
             G  C   +  C   C N   C   V   RC C   + G +C R
Sbjct: 443  MGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCER 486



 Score = 66.6 bits (161), Expect = 4e-10
 Identities = 68/263 (25%), Positives = 91/263 (34%), Gaps = 72/263 (27%)

Query: 3326 NRGYSLEGPSEAHCTENGTWSHP-----VPLCKPNPCPVPFVIPENALLSEKEFYVDQNV 3380
            N G  ++G +   C  +  W        +  C  NPC       +       +FY D   
Sbjct: 640  NGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLV----NDFYCD--- 692

Query: 3381 SIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITY 3440
               C+ G+             +T     ++C++ +C            G  Y  GD    
Sbjct: 693  ---CKNGW-----------KGKTCHSRDSQCDEATCNNG---------GTCYDEGDAFKC 729

Query: 3441 SCYSGYMLEGFL-----RSVCLENGTWTSPPICRAVCRFPCQNGGICQ---RPNACSCPE 3492
             C  G+  EG        S CL N               PC NGG C        C C E
Sbjct: 730  MCPGGW--EGTTCNIARNSSCLPN---------------PCHNGGTCVVNGESFTCVCKE 772

Query: 3493 GWMGRLCEE---PICILPCLNGGRCVAP---YQCDCPPGWTGSRCHTAV--CQ-SPCLNG 3543
            GW G +C +        PC N G CV     Y+C+C PG+ G  C   +  CQ SPC  G
Sbjct: 773  GWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFG 832

Query: 3544 GKCV---RPNRCHCLSSWTGHNC 3563
              CV      RC C    +G  C
Sbjct: 833  ATCVDEINGYRCVCPPGHSGAKC 855



 Score = 60.1 bits (144), Expect = 4e-08
 Identities = 29/85 (34%), Positives = 38/85 (44%), Gaps = 2/85 (2%)

Query: 3482 CQRPNACSCPEGWMGRLCEEPICILPCL-NGGRCVAPYQCDCPPGWTGSRCHTAVCQSPC 3540
            C +    +C EGWMG  C   IC   C    G C  P  C C  GW G  C   +    C
Sbjct: 212  CDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGC 271

Query: 3541 LNGGKCVRPNRCHCLSSWTGHNCSR 3565
            ++G  C  P +C C ++W G  C +
Sbjct: 272  VHG-ICNEPWQCLCETNWGGQLCDK 295



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 39/125 (31%), Positives = 51/125 (40%), Gaps = 26/125 (20%)

Query: 3449 EGFLRSVCLENGTWTSPPICRAVCRFPCQNGGICQRPN---ACSCPEGWMGRLCEEPI-- 3503
            EG+   +C +N    SP         PC N G C   +    C C  G+ G  C   I  
Sbjct: 772  EGWEGPICAQNTNDCSP--------HPCYNSGTCVDGDNWYRCECAPGFAGPDCRININE 823

Query: 3504 C-ILPCLNGGRCVAP---YQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRP--------NR 3551
            C   PC  G  CV     Y+C CPPG +G++C   V   PC+  G  +          N 
Sbjct: 824  CQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ-EVSGRPCITMGSVIPDGAKWDDDCNT 882

Query: 3552 CHCLS 3556
            C CL+
Sbjct: 883  CQCLN 887



 Score = 43.1 bits (100), Expect = 0.005
 Identities = 19/55 (34%), Positives = 23/55 (41%), Gaps = 7/55 (12%)

Query: 3518 YQCD------CPPGWTGSRCHTAVCQSPCL-NGGKCVRPNRCHCLSSWTGHNCSR 3565
            Y CD      C  GW G  C+ A+C+  C    G C  P  C C   W G  C +
Sbjct: 210  YACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDK 264



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 36/135 (26%), Positives = 46/135 (34%), Gaps = 36/135 (26%)

Query: 1744 LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGE 1803
            LD+D C   + C   A C N    Y C C   Y  +GKNC+              H    
Sbjct: 524  LDIDYCEP-NPCQNGAQCYNRASDYFCKCPEDY--EGKNCS--------------HLKDH 566

Query: 1804 IYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAF 1863
              T   EV  SC              + S +    + Y  +  CG    P   C  +   
Sbjct: 567  CRTTPCEVIDSC-----------TVAMASNDTPEGVRYISSNVCG----PHGKCKSQ--- 608

Query: 1864 TFGSKVTYRCNKGYT 1878
              G K T  CNKG+T
Sbjct: 609  -SGGKFTCDCNKGFT 622



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 64/268 (23%), Positives = 92/268 (34%), Gaps = 61/268 (22%)

Query: 288 CDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDEN 347
           C   G CK  +  G F C C KG+             +GTY  E     I+ C   P  N
Sbjct: 599 CGPHGKCKSQSG-GKFTCDCNKGF-------------TGTYCHE----NINDCESNPCRN 640

Query: 348 HTSPPGSTSPEDCVCREGYRASGQTCEL-VHCPALKPPENGYFIQNTCNNHF----NAAC 402
             +     +   C+C +G+   G  CE  ++  +  P  NG   ++  N+ +    N   
Sbjct: 641 GGTCIDGVNSYKCICSDGW--EGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWK 698

Query: 403 GVRCHP-------------GFDLVGSSIILCLPNGLWSGSESYCRV-RTCPHLRQPKHGH 448
           G  CH              G          C+  G W G+   C + R    L  P H  
Sbjct: 699 GKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTT--CNIARNSSCLPNPCHNG 756

Query: 449 ISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEP-----RCVER------H 497
            +C      +  TC+  C EG+  EG     C  N+    P P      CV+        
Sbjct: 757 GTCVVNGESF--TCV--CKEGW--EGP---ICAQNTNDCSPHPCYNSGTCVDGDNWYRCE 807

Query: 498 CSTFQMPKDVIISPHNCGKQPAKFGTIC 525
           C+      D  I+ + C   P  FG  C
Sbjct: 808 CAPGFAGPDCRININECQSSPCAFGATC 835



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 54/202 (26%), Positives = 79/202 (39%), Gaps = 25/202 (12%)

Query: 280 LCDEGKDCCDRMGSCKCG---THTG--HFECICEKGYYGKGLQYECTACPSGTYKPEGSP 334
           LCD+  + C     C  G   ++TG   ++C C +GY G   +    AC S      GS 
Sbjct: 292 LCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSC 351

Query: 335 GGISSCIPCP-DENHTSPPGSTSPEDCVCREGYRASGQTC-ELVH-CPALKPPENGYFIQ 391
              S    C      T P  ST+ +D  C     + G TC +LV+    + PP+   +  
Sbjct: 352 KETSLGFECECSPGWTGPTCSTNIDD--CSPNNCSHGGTCQDLVNGFKCVCPPQ---WTG 406

Query: 392 NTCN---NHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGH 448
            TC    N   A   V      +L+ S    CLP   W G      +  C  L Q ++  
Sbjct: 407 KTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPG--WMGQNCDININDC--LGQCQN-- 460

Query: 449 ISCSTREMLYKTTCLVACDEGY 470
              S R+++    C+  C  GY
Sbjct: 461 -DASCRDLVNGYRCI--CPPGY 479



 Score = 35.8 bits (81), Expect = 0.78
 Identities = 35/146 (23%), Positives = 59/146 (40%), Gaps = 23/146 (15%)

Query: 1658 CDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSAD-DFYAGSTVTYQC 1716
            CD      G   Q CLN G  +   P  ++  C  P     G+   + +    + ++  C
Sbjct: 293  CDKDLNYCGTH-QPCLNGGTCSNTGP--DKYQCSCP----EGYSGPNCEIAEHACLSDPC 345

Query: 1717 NNGYYLLGDSRMF-CTDNGSWNGVSPSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVP 1774
            +N       S  F C  +  W G  P+C  ++D+C+  ++CS   +C ++   + C C P
Sbjct: 346  HNRGSCKETSLGFECECSPGWTG--PTCSTNIDDCSP-NNCSHGGTCQDLVNGFKCVCPP 402

Query: 1775 PYTG----------DGKNCAEPIKCK 1790
             +TG          + K C     CK
Sbjct: 403  QWTGKTCQLDANECEAKPCVNAKSCK 428



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 35/149 (23%), Positives = 52/149 (34%), Gaps = 28/149 (18%)

Query: 1656 LFCD-----PG-FQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAG 1709
            L+CD     PG    + N    CL +  W   L   +   CG   P  NG          
Sbjct: 260  LYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGG--------- 310

Query: 1710 STVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYI 1769
                  C+N     G  +  C+    ++G  P+C   +   +   C    SC      + 
Sbjct: 311  -----TCSN----TGPDKYQCSCPEGYSG--PNCEIAEHACLSDPCHNRGSCKETSLGFE 359

Query: 1770 CSCVPPYTGDGKNCAEPIKCKAPGNPENG 1798
            C C P +T  G  C+  I   +P N  +G
Sbjct: 360  CECSPGWT--GPTCSTNIDDCSPNNCSHG 386



 Score = 34.7 bits (78), Expect = 1.7
 Identities = 33/135 (24%), Positives = 50/135 (37%), Gaps = 33/135 (24%)

Query: 278 SYLCD-----EGKDCC----DRMGSCK----CGTHTGHFECICEKGYYGKGLQYECTACP 324
           SY CD      G++C     D +G C+    C      + CIC  GY G   + +   C 
Sbjct: 433 SYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECA 492

Query: 325 SGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCEL-VHCPALKP 383
           S                PC +  H       +   C+C  G+  SG  C+L +      P
Sbjct: 493 SN---------------PCLNGGHCQ--NEINRFQCLCPTGF--SGNLCQLDIDYCEPNP 533

Query: 384 PENGYFIQNTCNNHF 398
            +NG    N  +++F
Sbjct: 534 CQNGAQCYNRASDYF 548



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 19/54 (35%), Positives = 25/54 (46%), Gaps = 4/54 (7%)

Query: 1730 CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNC 1783
            C     W G +   LD +EC     C    SC N+  SY C C+P +   G+NC
Sbjct: 398  CVCPPQWTGKTCQ-LDANECEA-KPCVNAKSCKNLIASYYCDCLPGWM--GQNC 447



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 32/129 (24%), Positives = 51/129 (39%), Gaps = 27/129 (20%)

Query: 1672 CLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYY--LLGDSRMF 1729
            C+  G W     +  R S  +P P  NG     +   G + T  C  G+   +   +   
Sbjct: 729  CMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVN---GESFTCVCKEGWEGPICAQNTND 785

Query: 1730 CTDNGSWNGVSPSCLDVD-----ECAVG---------------SDCSEHASCLNVDGSYI 1769
            C+ +  +N  S +C+D D     ECA G               S C+  A+C++    Y 
Sbjct: 786  CSPHPCYN--SGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYR 843

Query: 1770 CSCVPPYTG 1778
            C C P ++G
Sbjct: 844  CVCPPGHSG 852


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score =  237 bits (604), Expect = 2e-61
 Identities = 149/420 (35%), Positives = 192/420 (45%), Gaps = 76/420 (18%)

Query: 1021 GSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQ----CKQGTYSYSGLETCESCPLGT 1076
            G+ QD      C LCP   +T +  S ++ +C+ Q    C+ G               GT
Sbjct: 289  GTCQDGLDTYTC-LCPE-TWTGWDCSEDVDECETQGPPHCRNG---------------GT 331

Query: 1077 YQPKFGSRSCL--------SCPEN-----TSTVKRGAVNISACG---VPCPEGKFSRSGL 1120
             Q   GS  C+        SC EN      +T   G+  I   G     CP G   R+GL
Sbjct: 332  CQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPG---RTGL 388

Query: 1121 MPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASL 1180
            + CH       QP  G A C       T P  GS           T    +     P   
Sbjct: 389  L-CHLEDMCLSQPCHGDAQC------STNPLTGS-----------TLCLCQPGYSGPTC- 429

Query: 1181 GHIKKRHEISSQVFHECFF-----NPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDEC 1235
                       Q   EC       +PC + G+C      + CLCP GYTG +CE D +EC
Sbjct: 430  ----------HQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNEC 479

Query: 1236 SPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTC 1295
               PC     C DL+  F C CP G  GQ CE   NEC+S+PCLN   C D + G++C C
Sbjct: 480  LSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCIC 539

Query: 1296 VKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCK 1355
            + GF G  CE +++EC+S+PC N   C+DQ G F CKC PGF G RC   VDECLS PC 
Sbjct: 540  LPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCP 599

Query: 1356 NGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSG 1415
             GA+C D   +F CLC +GFTG  CE+ +  C  N C+ +  C D+ +  +C C  G  G
Sbjct: 600  VGASCLDLPGAFFCLCPSGFTGQLCEVPL--CAPNLCQPKQICKDQKDKANCLCPDGSPG 657



 Score =  234 bits (597), Expect = 1e-60
 Identities = 153/474 (32%), Positives = 196/474 (41%), Gaps = 88/474 (18%)

Query: 987  FCRPGSVLRGRMCVN--------CPLGTYYNLEHFTCE---------SCRIGS----YQD 1025
            F  PG   +G  C N        CP+G     E   CE          C  G       +
Sbjct: 199  FQDPGPCPKGTSCHNTLGSFQCLCPVGQ----EGPRCELRAGPCPPRGCSNGGTCQLMPE 254

Query: 1026 EEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRS 1085
            ++      LCP G           +    QC+ G     GL+T                +
Sbjct: 255  KDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTY---------------T 299

Query: 1086 CLSCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPF 1145
            CL CPE  +            G  C E         P H       Q +AG   C+    
Sbjct: 300  CL-CPETWT------------GWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSG 346

Query: 1146 YGTTPFA-------------GSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQ 1192
            +G T                GS  I    SFS         + PP   G +    ++   
Sbjct: 347  WGGTSCEENLDDCIAATCAPGSTCIDRVGSFSC--------LCPPGRTGLLCHLEDM--- 395

Query: 1193 VFHECFFNPCHNSGTCQQ--LGRGYVCLCPLGYTGLKCETDIDEC-----SPLPCLNNGV 1245
                C   PCH    C    L    +CLC  GY+G  C  D+DEC      P PC + G 
Sbjct: 396  ----CLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGS 451

Query: 1246 CKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCE 1305
            C +  G F C CP GYTG RCE + NEC S PC     C+D +A + C C  G  G  CE
Sbjct: 452  CLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCE 511

Query: 1306 TEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGAN 1365
             E NEC S PCLN+A C D + GF C C PGF GTRC +++DEC S PC NG  C+D   
Sbjct: 512  VETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPG 571

Query: 1366 SFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
            +F C C  GF G  C+  ++EC S+PC   A+C+D   ++ C C  GF+G+ CE
Sbjct: 572  AFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCE 625



 Score =  209 bits (533), Expect = 3e-53
 Identities = 146/483 (30%), Positives = 199/483 (41%), Gaps = 108/483 (22%)

Query: 1024 QDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGT----YSYSGLET------CESCP 1073
            +D++ +  C LCP G         N +     C++ +      ++G E       C S P
Sbjct: 641  KDQKDKANC-LCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAP 699

Query: 1074 L---GTYQPKFGSRSCLSCPENTSTVKRGAVNISAC-GVPCPEGKFSRSGLMPCHPCPRD 1129
                GT  P+    +C +CP    T    +  ++AC   PC  G         C+P P  
Sbjct: 700  CAHGGTCYPQPSGYNC-TCPTGY-TGPTCSEEMTACHSGPCLNGG-------SCNPSPGG 750

Query: 1130 YY----------QPNAGKAFCLACP-FYGTTPFAGSRSITECSSFSSTFSAAEESVVPPA 1178
            YY          Q      +C++ P F G T          C +   TFS          
Sbjct: 751  YYCTCPPSHTGPQCQTSTDYCVSAPCFNGGT----------CVNRPGTFSCL-------C 793

Query: 1179 SLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPL 1238
            ++G    R E   ++   C  +PC N  TCQ   +G  CLCP GYTG  C+T +D C+  
Sbjct: 794  AMGFQGPRCE--GKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQK 851

Query: 1239 PCLNN------------------------------------------------GVCKDLV 1250
            PC  N                                                G+C D  
Sbjct: 852  PCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSG 911

Query: 1251 GEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNE 1310
              + C CP G+ G  C++++N C S PC N   C+   +GY C C  G+ G +C  E++ 
Sbjct: 912  PSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDA 971

Query: 1311 CQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPC--KNGATCKDGANSFR 1368
            CQS PC N+  C  + GGF C CPPGF+G RC  +VDECL QPC     A C   AN+F 
Sbjct: 972  CQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFY 1031

Query: 1369 CLCAAGFTGSHCELNINECQSNPCRNQATCVDELNS---YSCKCQPGFSGKRC-ETEQST 1424
            C C  G TG  CE+ I+ C S PC +  TC     S   + C C  GF G  C     S 
Sbjct: 1032 CQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSC 1091

Query: 1425 GFN 1427
            GF+
Sbjct: 1092 GFH 1094



 Score =  206 bits (525), Expect = 3e-52
 Identities = 130/429 (30%), Positives = 185/429 (43%), Gaps = 52/429 (12%)

Query: 1029 QLECKLCPSGMYTEYIHSRNISDC---KAQCKQGTYSYSGLETCES-CPLGTYQPKFGSR 1084
            Q++C  CP G +  +   R++++C      C +GT  ++ L + +  CP+G   P+   R
Sbjct: 177  QIQCH-CPPG-FEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELR 234

Query: 1085 S-------------CLSCPENTSTVKRGAVNISACGVPC---PEGKFSRSGLMPCHPCPR 1128
            +             C   PE  ST           G  C   P+   S       H C  
Sbjct: 235  AGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVS-------HQCQN 287

Query: 1129 DYYQPNAGKAFCLACPFYGTTPFAGSRSITECSSFSSTF---------SAAEESVVPPAS 1179
                 +    +   CP    T +  S  + EC +              SA     V  + 
Sbjct: 288  GGTCQDGLDTYTCLCP-ETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSG 346

Query: 1180 LGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLP 1239
             G       +      +C    C    TC      + CLCP G TGL C  + D C   P
Sbjct: 347  WGGTSCEENLD-----DCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE-DMCLSQP 400

Query: 1240 CLNNGVCKD--LVGEFICECPSGYTGQRCEENINEC-----SSSPCLNKGICVDGVAGYR 1292
            C  +  C    L G  +C C  GY+G  C ++++EC       SPC + G C++    + 
Sbjct: 401  CHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFN 460

Query: 1293 CTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQ 1352
            C C  G+ G  CE + NEC S PC   + C D +  F C CPPG  G  C    +EC S 
Sbjct: 461  CLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASA 520

Query: 1353 PCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPG 1412
            PC N A C D  N F+C+C  GF+G+ CE +I+EC+S+PC N   C D+  ++ CKC PG
Sbjct: 521  PCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPG 580

Query: 1413 FSGKRCETE 1421
            F G RC+TE
Sbjct: 581  FEGPRCQTE 589



 Score =  199 bits (507), Expect = 3e-50
 Identities = 108/337 (32%), Positives = 147/337 (43%), Gaps = 38/337 (11%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            EC  +PC    +C  L   + CLCP G+TG  CE  +  C+P  C    +CKD   +  C
Sbjct: 592  ECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPL--CAPNLCQPKQICKDQKDKANC 649

Query: 1256 ECPSG----------------------------YTGQRCEENINECSSSPCLNKGICVDG 1287
             CP G                            +TG  CE  +  C S+PC + G C   
Sbjct: 650  LCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQ 709

Query: 1288 VAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVD 1347
             +GY CTC  G+ G  C  E+  C S PCLN   C    GG+ C CPP   G +C  + D
Sbjct: 710  PSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTD 769

Query: 1348 ECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNIN-ECQSNPCRNQATCVDELNSYS 1406
             C+S PC NG TC +   +F CLCA GF G  CE  +   C  +PCRN+ATC D      
Sbjct: 770  YCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPR 829

Query: 1407 CKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDGMLPSLHALTCTFWMKSSDDMNYG 1466
            C C  G++G  C+T            +    + +  G  PS H L    W     ++   
Sbjct: 830  CLCPTGYTGGSCQTLMDLCAQKPCPRN---SHCLQTG--PSFHCLCLQGWTGPLCNLPLS 884

Query: 1467 TPISYAVDNGSDNTLLLTDYNGWVLYVNGREKITNCP 1503
            +    A+  G D + L   +NG +   +G     +CP
Sbjct: 885  SCQKAALSQGIDVSSLC--HNGGLCVDSGPSYFCHCP 919



 Score =  189 bits (480), Expect = 4e-47
 Identities = 88/234 (37%), Positives = 120/234 (51%), Gaps = 9/234 (3%)

Query: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDEC--SPLPCLNNGVCKDLVGEFI 1254
            C  NPC N G C        C CP G+ G  CE D++EC   P PC     C + +G F 
Sbjct: 160  CSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQ 219

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICV----DGVAGYRCTCVKGFVGLHCETEVNE 1310
            C CP G  G RCE     C    C N G C          + C C  GF+G  CE   + 
Sbjct: 220  CLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDN 279

Query: 1311 CQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQP---CKNGATCKDGANSF 1367
            C S+ C N   C+D +  + C CP  + G  C ++VDEC +Q    C+NG TC++ A SF
Sbjct: 280  CVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSF 339

Query: 1368 RCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
             C+C +G+ G+ CE N+++C +  C   +TC+D + S+SC C PG +G  C  E
Sbjct: 340  HCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE 393



 Score =  184 bits (467), Expect = 1e-45
 Identities = 85/236 (36%), Positives = 123/236 (52%), Gaps = 15/236 (6%)

Query: 1202 CHNSGTCQQLGRG----YVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICEC 1257
            C N GTCQ +       ++CLCP G+ G  CE + D C    C N G C+D +  + C C
Sbjct: 243  CSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLC 302

Query: 1258 PSGYTGQRCEENINECSSSP---CLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
            P  +TG  C E+++EC +     C N G C +    + C CV G+ G  CE  +++C + 
Sbjct: 303  PETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAA 362

Query: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDG--ANSFRCLCA 1372
             C   + C D+VG F C CPPG  G  C    D CLSQPC   A C       S  CLC 
Sbjct: 363  TCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE-DMCLSQPCHGDAQCSTNPLTGSTLCLCQ 421

Query: 1373 AGFTGSHCELNINECQS-----NPCRNQATCVDELNSYSCKCQPGFSGKRCETEQS 1423
             G++G  C  +++EC       +PC +  +C++   S++C C PG++G RCE + +
Sbjct: 422  PGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHN 477



 Score =  181 bits (458), Expect = 2e-44
 Identities = 122/414 (29%), Positives = 156/414 (37%), Gaps = 55/414 (13%)

Query: 1032 CKLCPSGMYTEYIHSRNISDCK--------AQCKQG--TYSYSGLETCESCPLGTYQPKF 1081
            C   P G Y     S     C+        A C  G    +  G  +C  C +G   P+ 
Sbjct: 744  CNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSC-LCAMGFQGPRC 802

Query: 1082 GSRSCLSCPENTSTVKRGAVNISACGVPC--PEGKFSRS-----GLMPCHPCPRDYYQPN 1134
              +   SC ++     R     S  G  C  P G    S      L    PCPR+ +   
Sbjct: 803  EGKLRPSCADSPCR-NRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQ 861

Query: 1135 AGKAFCLACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVF 1194
             G +F   C    T P             SS   AA    +  +SL              
Sbjct: 862  TGPSFHCLCLQGWTGPLCNL-------PLSSCQKAALSQGIDVSSL-------------- 900

Query: 1195 HECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
                   CHN G C   G  Y C CP G+ G  C+  ++ C   PC N   C      ++
Sbjct: 901  -------CHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYL 953

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
            C+C  GY GQ C + ++ C S PC N G C     G+ C C  GFVGL CE +V+EC   
Sbjct: 954  CQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQ 1013

Query: 1315 PC--LNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANS---FRC 1369
            PC     A C      F C+C PG  G  C   +D C SQPC +G TC+  A S   F C
Sbjct: 1014 PCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFIC 1073

Query: 1370 LCAAGFTGSHCELNINECQSNPCRNQATCVDELN---SYSCKCQPGFSGKRCET 1420
             C  GF G  C      C  + C +   C+          C C  G+ G  C T
Sbjct: 1074 HCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLT 1127



 Score =  171 bits (433), Expect = 1e-41
 Identities = 85/229 (37%), Positives = 113/229 (49%), Gaps = 13/229 (5%)

Query: 1202 CHNSGTC--QQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPS 1259
            C   G C  Q  GR   C C  G+TG +C+   D CS  PC+N GVC     +  C CP 
Sbjct: 127  CSKRGRCHIQASGRPQ-CSCMPGWTGEQCQLR-DFCSANPCVNGGVCLATYPQIQCHCPP 184

Query: 1260 GYTGQRCEENINEC--SSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCL 1317
            G+ G  CE ++NEC     PC     C + +  ++C C  G  G  CE     C    C 
Sbjct: 185  GFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCS 244

Query: 1318 NNAVC----EDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAA 1373
            N   C    E      LC CPPGF+G  C  N D C+S  C+NG TC+DG +++ CLC  
Sbjct: 245  NGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPE 304

Query: 1374 GFTGSHCELNINECQSN---PCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
             +TG  C  +++EC++     CRN  TC +   S+ C C  G+ G  CE
Sbjct: 305  TWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCE 353



 Score =  153 bits (386), Expect = 3e-36
 Identities = 87/246 (35%), Positives = 116/246 (47%), Gaps = 26/246 (10%)

Query: 1198 FFNPCHNSGTCQQLGRGY-VCLCPLGYTGLKCETDIDECSPLP-CLNNGVCKDLVG---- 1251
            F  PC N GTC  L  G   C C  G+ G  C+   D C     C N G C+ L+     
Sbjct: 31   FPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFP-DPCQNAQLCQNGGSCQALLPAPLG 89

Query: 1252 ----------EFICECPSGYTGQRCEENINE-CSSSPCLNKGICVDGVAGY-RCTCVKGF 1299
                       F+C C  G+TG+RC+  + + C  S C  +G C    +G  +C+C+ G+
Sbjct: 90   LPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGW 149

Query: 1300 VGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQ--PCKNG 1357
             G  C+   + C +NPC+N  VC        C CPPGF G  C ++V+EC     PC  G
Sbjct: 150  TGEQCQLR-DFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKG 208

Query: 1358 ATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATC--VDELNS--YSCKCQPGF 1413
             +C +   SF+CLC  G  G  CEL    C    C N  TC  + E +S  + C C PGF
Sbjct: 209  TSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGF 268

Query: 1414 SGKRCE 1419
             G  CE
Sbjct: 269  IGPDCE 274



 Score =  126 bits (317), Expect = 3e-28
 Identities = 72/206 (34%), Positives = 89/206 (43%), Gaps = 15/206 (7%)

Query: 1191 SQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNG--VCKD 1248
            S+    C   PCHN GTC     G+ C CP G+ GL+CE D+DEC   PC   G   C  
Sbjct: 966  SKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHS 1025

Query: 1249 LVGEFICECPSGYTGQRCEENINECSSSPCLNKGIC---VDGVAGYRCTCVKGFVGLHCE 1305
            L   F C+C  G+TGQ CE  I+ C S PC + G C        G+ C C KGF G  C 
Sbjct: 1026 LANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCS 1085

Query: 1306 TEVNECQSNPCLNNAVC-EDQVGGF--LCKCPPGFLGTRC--GKNVDEC-LSQPCKNGAT 1359
                 C  + C +  +C      GF   C C  G+ G  C        C    PC    +
Sbjct: 1086 HRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGS 1145

Query: 1360 CKD----GANSFRCLCAAGFTGSHCE 1381
            C +    G   FRC C     G  C+
Sbjct: 1146 CSETTGLGGPGFRCSCPHSSPGPRCQ 1171



 Score = 87.8 bits (216), Expect = 2e-16
 Identities = 56/175 (32%), Positives = 72/175 (41%), Gaps = 34/175 (19%)

Query: 1277 PCLNKGICVDGVAGY-RCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGG------- 1328
            PC N G C+    G   C C  GF+G  C+        +PC N  +C++  GG       
Sbjct: 34   PCANGGTCLSLSLGQGTCQCAPGFLGETCQFP------DPCQNAQLCQN--GGSCQALLP 85

Query: 1329 ---------------FLCKCPPGFLGTRC-GKNVDECLSQPCKNGATCKDGANSF-RCLC 1371
                           FLC C PGF G RC  K  D C    C     C   A+   +C C
Sbjct: 86   APLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSC 145

Query: 1372 AAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGF 1426
              G+TG  C+L  + C +NPC N   C+       C C PGF G  CE + +  F
Sbjct: 146  MPGWTGEQCQLR-DFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECF 199



 Score = 82.8 bits (203), Expect = 6e-15
 Identities = 54/147 (36%), Positives = 69/147 (46%), Gaps = 24/147 (16%)

Query: 3441 SCYSGYMLEGFLRSVCLENGTWTSPPICRA----VCRFPCQNGGICQ-RPNA--CSCPEG 3493
            +C+ G+      RS C+ +  WT P  C A        PC +GG C  +P+   C+CP G
Sbjct: 666  TCHHGHCQ----RSSCVCDVGWTGPE-CEAELGGCISAPCAHGGTCYPQPSGYNCTCPTG 720

Query: 3494 WMGRLCEEPICIL---PCLNGGRC---VAPYQCDCPPGWTGSRCHTAV---CQSPCLNGG 3544
            + G  C E +      PCLNGG C      Y C CPP  TG +C T+      +PC NGG
Sbjct: 721  YTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGG 780

Query: 3545 KCV-RPN--RCHCLSSWTGHNCSRKRR 3568
             CV RP    C C   + G  C  K R
Sbjct: 781  TCVNRPGTFSCLCAMGFQGPRCEGKLR 807



 Score = 69.3 bits (168), Expect = 6e-11
 Identities = 50/155 (32%), Positives = 64/155 (41%), Gaps = 39/155 (25%)

Query: 3450 GFLRSVCLENGTWT-SPPICRAVCRFP--------CQNGGICQR--------PNA----- 3487
            G   S+ L  GT   +P      C+FP        CQNGG CQ         P++     
Sbjct: 39   GTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLT 98

Query: 3488 ----CSCPEGWMGRLC----EEPICILPCLNGGRCVAPY----QCDCPPGWTGSRCHTA- 3534
                C+C  G+ G  C    E+P     C   GRC        QC C PGWTG +C    
Sbjct: 99   PSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRD 158

Query: 3535 -VCQSPCLNGGKCVRPN---RCHCLSSWTGHNCSR 3565
                +PC+NGG C+      +CHC   + GH C R
Sbjct: 159  FCSANPCVNGGVCLATYPQIQCHCPPGFEGHACER 193



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 78/297 (26%), Positives = 101/297 (34%), Gaps = 81/297 (27%)

Query: 3331 LEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLL 3390
            L G   A C   GT  +P P      CP  +  P     SE+           C  G  L
Sbjct: 692  LGGCISAPCAHGGT-CYPQPSGYNCTCPTGYTGPT---CSEE--------MTACHSGPCL 739

Query: 3391 QGHGI--------ITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSC 3442
             G            TC P  T  Q     +     P  +    + R          T+SC
Sbjct: 740  NGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPG--------TFSC 791

Query: 3443 -----YSGYMLEGFLRSVCLENGTWT------SPPICRAVC-----------------RF 3474
                 + G   EG LR  C ++          SP   R +C                 + 
Sbjct: 792  LCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQK 851

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPICILP-------------CLNGGRCV--- 3515
            PC     C +      C C +GW G LC  P+                 C NGG CV   
Sbjct: 852  PCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSG 911

Query: 3516 APYQCDCPPGWTGSRC--HTAVCQS-PCLNGGKCV-RPN--RCHCLSSWTGHNCSRK 3566
              Y C CPPG+ GS C  H   C+S PC NG  C+ +P+   C C   + G NCS++
Sbjct: 912  PSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKE 968



 Score = 63.9 bits (154), Expect = 3e-09
 Identities = 39/104 (37%), Positives = 50/104 (48%), Gaps = 15/104 (14%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCE---EPICILPCLNGGRC---VAPYQCDCPPG 3525
            PC  G  C    A   C CP G  G+LCE         PCLN   C   +  +QC C PG
Sbjct: 483  PCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPG 542

Query: 3526 WTGSRCHTAVCQ---SPCLNGGKCV-RPN--RCHCLSSWTGHNC 3563
            ++G+RC   + +   SPC NGG+C  +P    C CL  + G  C
Sbjct: 543  FSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRC 586



 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 48/149 (32%), Positives = 63/149 (42%), Gaps = 23/149 (15%)

Query: 3438 ITYSCYSGYMLEGFLRS-VCLENGTWT----SPPICRAVCRFP--CQNGGICQRPNA--- 3487
            +++ C +G   +  L +  CL   TWT    S  +     + P  C+NGG CQ       
Sbjct: 281  VSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFH 340

Query: 3488 CSCPEGWMGRLCEEPI--CILP-CLNGGRC---VAPYQCDCPPGWTGSRCHTA-VCQS-P 3539
            C C  GW G  CEE +  CI   C  G  C   V  + C CPPG TG  CH   +C S P
Sbjct: 341  CVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQP 400

Query: 3540 CLNGGKC-----VRPNRCHCLSSWTGHNC 3563
            C    +C          C C   ++G  C
Sbjct: 401  CHGDAQCSTNPLTGSTLCLCQPGYSGPTC 429



 Score = 60.5 bits (145), Expect = 3e-08
 Identities = 59/192 (30%), Positives = 72/192 (37%), Gaps = 43/192 (22%)

Query: 3395 IITCNPDETWTQTSAKCEKISCGPPAHVENAIARG-VHYQYGDMITYSCYSGYMLEGF-L 3452
            + TC P  T  +  AK E   C PP+       RG  H Q       SC  G+  E   L
Sbjct: 102  LCTCLPGFTGERCQAKLED-PC-PPSFCSK---RGRCHIQASGRPQCSCMPGWTGEQCQL 156

Query: 3453 RSVCLENGTWTSPPICRAVCRFPCQNGGICQRPNA---CSCPEGWMGRLCEEPI--CIL- 3506
            R  C  N               PC NGG+C        C CP G+ G  CE  +  C   
Sbjct: 157  RDFCSAN---------------PCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQD 201

Query: 3507 --PCLNGGRC---VAPYQCDCPPGWTGSRCHTAVCQSP---CLNGGKC-VRPNR------ 3551
              PC  G  C   +  +QC CP G  G RC       P   C NGG C + P +      
Sbjct: 202  PGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHL 261

Query: 3552 CHCLSSWTGHNC 3563
            C C   + G +C
Sbjct: 262  CLCPPGFIGPDC 273



 Score = 60.5 bits (145), Expect = 3e-08
 Identities = 66/257 (25%), Positives = 86/257 (33%), Gaps = 60/257 (23%)

Query: 3357 CPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQ-GHGIITCNPDETWTQTSAKCEKIS 3415
            CP  F+ P+       E   D  VS +C+ G   Q G    TC   ETWT      +   
Sbjct: 264  CPPGFIGPDC------EVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDE 317

Query: 3416 C---GPPAHVENAIARGVHYQYGDMITYSCYSGY-------MLEGFLRSVCLENGTWTS- 3464
            C   GPP H  N    G            C SG+        L+  + + C    T    
Sbjct: 318  CETQGPP-HCRNG---GTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDR 373

Query: 3465 ---------PPICRAVCRF-------PCQNGGICQR-----PNACSCPEGWMGRLCEEPI 3503
                     P     +C         PC     C          C C  G+ G  C + +
Sbjct: 374  VGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDL 433

Query: 3504 --CIL------PCLNGGRCV---APYQCDCPPGWTGSRC---HTAVCQSPCLNGGKC--- 3546
              C++      PC +GG C+     + C CPPG+TGSRC   H      PC  G  C   
Sbjct: 434  DECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDL 493

Query: 3547 VRPNRCHCLSSWTGHNC 3563
            +    C C     G  C
Sbjct: 494  LATFHCLCPPGLEGQLC 510



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 39/123 (31%), Positives = 47/123 (38%), Gaps = 36/123 (29%)

Query: 3475 PCQNGGICQR----PNACSCPEGWMGRLCEEP-IC--ILPCLNGGRCVA----------- 3516
            PC NGG C         C C  G++G  C+ P  C     C NGG C A           
Sbjct: 34   PCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSS 93

Query: 3517 ------PYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRPNRCH----------CLSSWTG 3560
                   + C C PG+TG RC  A  + PC     C +  RCH          C+  WTG
Sbjct: 94   PSPLTPSFLCTCLPGFTGERCQ-AKLEDPC-PPSFCSKRGRCHIQASGRPQCSCMPGWTG 151

Query: 3561 HNC 3563
              C
Sbjct: 152  EQC 154



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 65/243 (26%), Positives = 85/243 (34%), Gaps = 73/243 (30%)

Query: 286 DCCDRMGSCKCGTHT----GHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCI 341
           +C    G C  GT      G F+C+C  G  G   +     CP     P G   G  +C 
Sbjct: 197 ECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCP-----PRGCSNG-GTCQ 250

Query: 342 PCPDENHT-----SPPG------STSPEDCV---------CREGYRA---------SGQT 372
             P+++ T      PPG        +P++CV         C++G            +G  
Sbjct: 251 LMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWD 310

Query: 373 C--ELVHCPALKPP--ENGYFIQN----------------TCNNHFNAACGVRCHPG--- 409
           C  ++  C    PP   NG   QN                +C  + +      C PG   
Sbjct: 311 CSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTC 370

Query: 410 FDLVGSSIILCLP--NGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACD 467
            D VGS   LC P   GL    E  C       L QP HG   CST  +   T CL  C 
Sbjct: 371 IDRVGSFSCLCPPGRTGLLCHLEDMC-------LSQPCHGDAQCSTNPLTGSTLCL--CQ 421

Query: 468 EGY 470
            GY
Sbjct: 422 PGY 424



 Score = 56.6 bits (135), Expect = 4e-07
 Identities = 41/104 (39%), Positives = 47/104 (45%), Gaps = 15/104 (14%)

Query: 3475 PCQNGGICQ---RPNACSCPEGWMGRLCEEPI--C-ILPCLNGGRCV---APYQCDCPPG 3525
            PC N   C        C C  G+ G  CEE I  C   PC NGG+C      + C C PG
Sbjct: 521  PCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPG 580

Query: 3526 WTGSRCHTAV--CQS-PCLNGGKCV-RPNR--CHCLSSWTGHNC 3563
            + G RC T V  C S PC  G  C+  P    C C S +TG  C
Sbjct: 581  FEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLC 624



 Score = 53.9 bits (128), Expect = 3e-06
 Identities = 169/746 (22%), Positives = 229/746 (30%), Gaps = 153/746 (20%)

Query: 2914 TFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQY 2973
            TFHC     L G     C+ + N  A  P     +C       H   NGF  I       
Sbjct: 496  TFHCLCPPGLEGQ---LCEVETNECASAPCLNHADC-------HDLLNGFQCI------- 538

Query: 2974 QCFPGYKLHGNSSRRC-----------LSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDF 3022
             C PG+     S  RC            +NG      P    C+C  P  E G    T+ 
Sbjct: 539  -CLPGF-----SGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKC-LPGFE-GPRCQTEV 590

Query: 3023 DCGKAARIQCFKGFKLLGL-SEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSW 3081
            D  +     C  G   L L     C     ++     CE   C      P     +    
Sbjct: 591  D--ECLSDPCPVGASCLDLPGAFFCLCPSGFTGQL--CEVPLCAPNLCQPKQICKDQKD- 645

Query: 3082 KENVI-------------TYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSV 3128
            K N +               +C  G+  + S    C     W+ P    E   C S P  
Sbjct: 646  KANCLCPDGSPGCAPPEDNCTCHHGHCQRSS----CVCDVGWTGPECEAELGGCISAPCA 701

Query: 3129 ANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFT------CQKDGRWFPER----ISCSP 3178
                  G  +   S     C  GYT  T ++  T      C   G   P       +C P
Sbjct: 702  HG----GTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPP 757

Query: 3179 KKC-PLPENITHILVHGDDFS----VNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSD 3233
                P  +  T   V    F+    VNR  + SC     F+G      + +G   P  +D
Sbjct: 758  SHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGP-----RCEGKLRPSCAD 812

Query: 3234 ESC-SPVSC-GKPESPE----HGFVVGSKYTFESTIIYQCEP--GYELEGNRERVCQENR 3285
              C +  +C   P+ P      G+  GS  T       +  P   + L+      C   +
Sbjct: 813  SPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQ 872

Query: 3286 QWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSL--EGPSE-AHCT-- 3340
             W+G +       C  PL      A     + G +V   C+ G      GPS   HC   
Sbjct: 873  GWTGPL-------CNLPLSSCQKAA----LSQGIDVSSLCHNGGLCVDSGPSYFCHCPPG 921

Query: 3341 -ENGTWSHPVPLCKPNPCP---VPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGII 3396
             +       V  C+  PC         P   L      Y  QN S +         H   
Sbjct: 922  FQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHG 981

Query: 3397 TCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVC 3456
            TC P       +     +       V+  + +  H       T +C+S   L       C
Sbjct: 982  TCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCH----PTGTAACHS---LANAFYCQC 1034

Query: 3457 L--ENGTWTSPPI--CRAVCRFPCQNGGICQRPNA------CSCPEGWMGRLCEE--PIC 3504
            L    G W    I  C +    PC +GG C+          C CP+G+ G  C    P C
Sbjct: 1035 LPGHTGQWCEVEIDPCHSQ---PCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSC 1091

Query: 3505 -ILPCLNGGRCVA------PYQCDCPPGWTGSRCHTAVC------QSPCLNGGKCVRPN- 3550
                C +GG C+       P +C C  G+ G  C T          SPCL  G C     
Sbjct: 1092 GFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTG 1151

Query: 3551 ------RCHCLSSWTGHNCSRKRRTG 3570
                  RC C  S  G  C +    G
Sbjct: 1152 LGGPGFRCSCPHSSPGPRCQKPGAKG 1177



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 63/260 (24%), Positives = 84/260 (32%), Gaps = 68/260 (26%)

Query: 266 SGSFIQDDMVHCSYLCDE---GKDCCDRMGSCK------------CGTHTGHFECICEKG 310
           +G   QD +   + LC E   G DC + +  C+            C    G F C+C  G
Sbjct: 287 NGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSG 346

Query: 311 YYGKGLQYECTACPSGTYKPEGS---PGGISSCI-------------------PCPDENH 348
           + G   +     C + T  P  +     G  SC+                   PC  +  
Sbjct: 347 WGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQ 406

Query: 349 TSPPGSTSPEDCVCREGYRASGQTC--ELVHC----PALKPPENGYFIQNT--------- 393
            S    T    C+C+ GY  SG TC  +L  C        P E+G    NT         
Sbjct: 407 CSTNPLTGSTLCLCQPGY--SGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCP 464

Query: 394 -------CNNHFNAACGVRCHPG---FDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQ 443
                  C    N      CHPG    DL+ +   LC P GL       C V T      
Sbjct: 465 PGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLC-PPGL---EGQLCEVETNECASA 520

Query: 444 PKHGHISCSTREMLYKTTCL 463
           P   H  C      ++  CL
Sbjct: 521 PCLNHADCHDLLNGFQCICL 540



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 73/285 (25%), Positives = 94/285 (32%), Gaps = 92/285 (32%)

Query: 230 ELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHC-SYLCDEGKDCC 288
           E N+ AS P   H         F+ +          SG+  ++D+  C S  C  G  C 
Sbjct: 513 ETNECASAPCLNHADCHDLLNGFQCICLPGF-----SGTRCEEDIDECRSSPCANGGQCQ 567

Query: 289 DRMGS--CKC-----------------------GTHT----GHFECICEKGYYGKGLQYE 319
           D+ G+  CKC                       G       G F C+C  G+ G+  +  
Sbjct: 568 DQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVP 627

Query: 320 CTA---------CPSGTYK-----PEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREG 365
             A         C     K     P+GSPG    C P P++N T   G      CVC  G
Sbjct: 628 LCAPNLCQPKQICKDQKDKANCLCPDGSPG----CAP-PEDNCTCHHGHCQRSSCVCDVG 682

Query: 366 YRASGQTCE----------LVHCPALKPPENGY-------FIQNTCNNHFNAACGVRCHP 408
           +  +G  CE            H     P  +GY       +   TC+    A     CH 
Sbjct: 683 W--TGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTA-----CHS 735

Query: 409 GFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCST 453
           G  L G S   C P    S    YC   TCP    P H    C T
Sbjct: 736 GPCLNGGS---CNP----SPGGYYC---TCP----PSHTGPQCQT 766



 Score = 44.7 bits (104), Expect = 0.002
 Identities = 37/117 (31%), Positives = 45/117 (38%), Gaps = 24/117 (20%)

Query: 276 HC---SYLCD---EGKDCCDRMGSC---------KCGTHTGHFECICEKGYYGKGLQYEC 320
           HC   S +CD    G +C   +G C          C      + C C  GY G     E 
Sbjct: 671 HCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEM 730

Query: 321 TACPSGTYKPEG----SPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTC 373
           TAC SG     G    SPGG     P    +HT P   TS + CV    +  +G TC
Sbjct: 731 TACHSGPCLNGGSCNPSPGGYYCTCP---PSHTGPQCQTSTDYCVSAPCF--NGGTC 782



 Score = 41.6 bits (96), Expect = 0.014
 Identities = 27/84 (32%), Positives = 34/84 (40%), Gaps = 24/84 (28%)

Query: 3507 PCLNGGRCVA----PYQCDCPPGWTGSRCHTA-VCQSP--CLNGGKC------------- 3546
            PC NGG C++       C C PG+ G  C     CQ+   C NGG C             
Sbjct: 34   PCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSS 93

Query: 3547 ---VRPN-RCHCLSSWTGHNCSRK 3566
               + P+  C CL  +TG  C  K
Sbjct: 94   PSPLTPSFLCTCLPGFTGERCQAK 117



 Score = 40.8 bits (94), Expect = 0.024
 Identities = 20/43 (46%), Positives = 24/43 (55%), Gaps = 5/43 (11%)

Query: 1741 PSC-LDVDECAVG----SDCSEHASCLNVDGSYICSCVPPYTG 1778
            P+C  D+DEC +     S C    SCLN  GS+ C C P YTG
Sbjct: 427  PTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTG 469



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 31/121 (25%), Positives = 44/121 (36%), Gaps = 16/121 (13%)

Query: 1668 PVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDS- 1726
            P  +CL    WT PL +    SC                  G  V+  C+NG   +    
Sbjct: 864  PSFHCLCLQGWTGPLCNLPLSSC-----------QKAALSQGIDVSSLCHNGGLCVDSGP 912

Query: 1727 RMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEP 1786
              FC     + G    C D         C   A+C+     Y+C C P Y  DG+NC++ 
Sbjct: 913  SYFCHCPPGFQG--SLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGY--DGQNCSKE 968

Query: 1787 I 1787
            +
Sbjct: 969  L 969



 Score = 36.2 bits (82), Expect = 0.60
 Identities = 35/138 (25%), Positives = 49/138 (35%), Gaps = 23/138 (16%)

Query: 265 PSGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGT---HTGHFECICEKGYYGKGLQYECT 321
           P G +      H    C    D C        GT     G F C+C  G+ G   +    
Sbjct: 748 PGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCE---- 803

Query: 322 ACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCE-LVHCPA 380
               G  +P        SC   P  N  +   S     C+C  GY  +G +C+ L+   A
Sbjct: 804 ----GKLRP--------SCADSPCRNRATCQDSPQGPRCLCPTGY--TGGSCQTLMDLCA 849

Query: 381 LKP-PENGYFIQNTCNNH 397
            KP P N + +Q   + H
Sbjct: 850 QKPCPRNSHCLQTGPSFH 867



 Score = 35.8 bits (81), Expect = 0.78
 Identities = 61/261 (23%), Positives = 81/261 (31%), Gaps = 65/261 (24%)

Query: 278  SYLCD-----EGKDCCDRMGSCK---------CGTHTGHFECICEKGYYGKGLQYECTAC 323
            SY C      +G  C D +  C+         C      + C C  GY G+    E  AC
Sbjct: 913  SYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDAC 972

Query: 324  PS------GTYKPEGSPGG-----------------ISSCI--PCPDENHTSPPGSTSPE 358
             S      GT  P+  PGG                 +  C+  PC      +     +  
Sbjct: 973  QSQPCHNHGTCTPK--PGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAF 1030

Query: 359  DCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSII 418
             C C  G+  +GQ CE+   P    P    F   TC     +  G  CH           
Sbjct: 1031 YCQCLPGH--TGQWCEVEIDPCHSQP---CFHGGTCEATAGSPLGFICH----------- 1074

Query: 419  LCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKL 478
               P G + G     R  +C       HG +   + +  +   C  AC  GY   G D L
Sbjct: 1075 --CPKG-FEGPTCSHRAPSC-GFHHCHHGGLCLPSPKPGFPPRC--ACLSGY--GGPDCL 1126

Query: 479  TCQGNSQWDGPEPRCVERHCS 499
            T         P P      CS
Sbjct: 1127 TPPAPKGCGPPSPCLYNGSCS 1147



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 16/39 (41%), Positives = 23/39 (58%), Gaps = 2/39 (5%)

Query: 1741 PSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778
            P C  +VDEC +   C   ASCL++ G++ C C   +TG
Sbjct: 584  PRCQTEVDEC-LSDPCPVGASCLDLPGAFFCLCPSGFTG 621



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 34/135 (25%), Positives = 49/135 (36%), Gaps = 13/135 (9%)

Query: 1650 PGSKVNLFCDPGFQLVGNPVQYCLNQ--GQWTQPLPHC----ERISCGVPPPLENGFHSA 1703
            PGS  N  C PG+   G+  +   N+   Q   P   C        C  PP LE      
Sbjct: 456  PGS-FNCLCPPGY--TGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEV 512

Query: 1704 DDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLN 1763
            +     S       + + LL   +  C    S         D+DEC   S C+    C +
Sbjct: 513  ETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEE---DIDECR-SSPCANGGQCQD 568

Query: 1764 VDGSYICSCVPPYTG 1778
              G++ C C+P + G
Sbjct: 569  QPGAFHCKCLPGFEG 583



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 71/308 (23%), Positives = 102/308 (33%), Gaps = 50/308 (16%)

Query: 1653 KVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSAD-DFYAGST 1711
            K N  C  G      P   C      T    HC+R SC      + G+   + +   G  
Sbjct: 646  KANCLCPDGSPGCAPPEDNC------TCHHGHCQRSSC----VCDVGWTGPECEAELGGC 695

Query: 1712 VTYQCNNGYYLLGDSRMF-CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYIC 1770
            ++  C +G         + CT    + G  P+C +         C    SC    G Y C
Sbjct: 696  ISAPCAHGGTCYPQPSGYNCTCPTGYTG--PTCSEEMTACHSGPCLNGGSCNPSPGGYYC 753

Query: 1771 SCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQ-----EGYQLMGVT 1825
            +C P +TG     +      AP    NG +      V    TFSC      +G +  G  
Sbjct: 754  TCPPSHTGPQCQTSTDYCVSAP--CFNGGT-----CVNRPGTFSCLCAMGFQGPRCEGKL 806

Query: 1826 KITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYR--C------NKGY 1877
            + +C +S   N      +A     P  P   C+    +T GS  T    C         +
Sbjct: 807  RPSCADSPCRN------RATCQDSPQGPR--CLCPTGYTGGSCQTLMDLCAQKPCPRNSH 858

Query: 1878 TLAGDKESSCLANSSWSHSPPVCE-PVKCSSPENINNGKYILS-----GLTYLSTASYSC 1931
             L       CL    W  + P+C  P+       ++ G  + S     GL   S  SY C
Sbjct: 859  CLQTGPSFHCLCLQGW--TGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFC 916

Query: 1932 DTGYSLQG 1939
                  QG
Sbjct: 917  HCPPGFQG 924



 Score = 33.5 bits (75), Expect = 3.9
 Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 3/64 (4%)

Query: 1716 CNNGYYLLGDSRMF-CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVP 1774
            C NG      +  F C     W G S    ++D+C + + C+  ++C++  GS+ C C P
Sbjct: 326  CRNGGTCQNSAGSFHCVCVSGWGGTSCE-ENLDDC-IAATCAPGSTCIDRVGSFSCLCPP 383

Query: 1775 PYTG 1778
              TG
Sbjct: 384  GRTG 387


>gi|110735443 delta-like 1 [Homo sapiens]
          Length = 723

 Score =  236 bits (603), Expect = 2e-61
 Identities = 99/221 (44%), Positives = 125/221 (56%), Gaps = 2/221 (0%)

Query: 1201 PCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPS 1259
            PC N  TC   G+G Y C C  GYTG  CE  IDEC P PC N G C DL   + C CP 
Sbjct: 297  PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPP 356

Query: 1260 GYTGQRCEENINECSSSPCLNKGICVDGV-AGYRCTCVKGFVGLHCETEVNECQSNPCLN 1318
            G+ G+ CE +   C+  PC N G C D    GY C C  G+ G +CE +++ C S+PC N
Sbjct: 357  GFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSN 416

Query: 1319 NAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGS 1378
             A C D    +LC+C  GF G  C  NVD+C S PC NG TC+DG N F C C  G+TG 
Sbjct: 417  GAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGR 476

Query: 1379 HCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
            +C   ++ C+  PC N ATC +  + Y C+C  G+ G  C+
Sbjct: 477  NCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ 517



 Score =  216 bits (549), Expect = 4e-55
 Identities = 102/246 (41%), Positives = 129/246 (52%), Gaps = 6/246 (2%)

Query: 1181 GHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSP-LP 1239
            G  K R     +   EC   P    GTCQQ    + C C  G+ GL C  D++ C+   P
Sbjct: 241  GECKCRVGWQGRYCDECIRYPGCLHGTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKP 297

Query: 1240 CLNNGVCKDL-VGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKG 1298
            C N   C +   G + C C  GYTG  CE  I+EC  SPC N G C D    Y CTC  G
Sbjct: 298  CKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPG 357

Query: 1299 FVGLHCETEVNECQSNPCLNNAVCEDQV-GGFLCKCPPGFLGTRCGKNVDECLSQPCKNG 1357
            F G  CE     C   PC N   C D   GG+ C+CP G+ G  C K +D C S PC NG
Sbjct: 358  FYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNG 417

Query: 1358 ATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKR 1417
            A C D  +++ C C AGF+G HC+ N+++C S+PC N  TC D +N +SC C PG++G+ 
Sbjct: 418  AKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRN 477

Query: 1418 CETEQS 1423
            C    S
Sbjct: 478  CSAPVS 483



 Score =  192 bits (488), Expect = 5e-48
 Identities = 85/197 (43%), Positives = 105/197 (53%), Gaps = 1/197 (0%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLV-GEFI 1254
            EC  +PC N G+C  L   Y C CP G+ G  CE     C+  PC N G C D   G + 
Sbjct: 331  ECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYS 390

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
            C CP GY+G  CE+ I+ CSSSPC N   CVD    Y C C  GF G HC+  V++C S+
Sbjct: 391  CRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASS 450

Query: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
            PC N   C D V  F C CPPG+ G  C   V  C   PC NGATC +  + + C CA G
Sbjct: 451  PCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARG 510

Query: 1375 FTGSHCELNINECQSNP 1391
            + G +C+  + E    P
Sbjct: 511  YGGPNCQFLLPELPPGP 527



 Score =  119 bits (298), Expect = 5e-26
 Identities = 79/232 (34%), Positives = 106/232 (45%), Gaps = 36/232 (15%)

Query: 1203 HNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYT 1262
            H+SG    L   Y  +C   Y G  C      C P          D  G F C       
Sbjct: 164  HSSGRTD-LKYSYRFVCDEHYYGEGCSVF---CRPRD--------DAFGHFTC------- 204

Query: 1263 GQRCEENINECSSSPCLNKGICVDGVA---GY-----RCTCVKGFVGLHCETEVNECQSN 1314
            G+R E+  N     P   + IC+ G     G+      C C  G+ G +C+    EC   
Sbjct: 205  GERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCD----ECIRY 260

Query: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLS-QPCKNGATCKD-GANSFRCLCA 1372
            P   +  C+     + C C  G+ G  C ++++ C   +PCKNGATC + G  S+ C C 
Sbjct: 261  PGCLHGTCQQP---WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCR 317

Query: 1373 AGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQST 1424
             G+TG+ CEL I+EC  +PC+N  +C D  NSYSC C PGF GK CE    T
Sbjct: 318  PGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMT 369



 Score =  114 bits (285), Expect = 2e-24
 Identities = 44/121 (36%), Positives = 66/121 (54%)

Query: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICE 1256
            C  +PC N   C  LG  Y+C C  G++G  C+ ++D+C+  PC N G C+D V +F C 
Sbjct: 409  CSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCT 468

Query: 1257 CPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPC 1316
            CP GYTG+ C   ++ C  +PC N   C +    Y C C +G+ G +C+  + E    P 
Sbjct: 469  CPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPA 528

Query: 1317 L 1317
            +
Sbjct: 529  V 529



 Score = 78.2 bits (191), Expect = 1e-13
 Identities = 82/311 (26%), Positives = 118/311 (37%), Gaps = 45/311 (14%)

Query: 988  CRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIGSYQDEEGQLECKLCPSGMYTEYIHSR 1047
            CR G   +GR C  C    Y    H TC+     + Q+  G L C        T +   +
Sbjct: 245  CRVG--WQGRYCDECI--RYPGCLHGTCQQPWQCNCQEGWGGLFCNQ-DLNYCTHHKPCK 299

Query: 1048 NISDCKAQCKQGTYSYS------------GLETCESCPL---GTYQPKFGSRSCLSCPEN 1092
            N + C     QG+Y+ S            G++ C+  P    G+      S SC   P  
Sbjct: 300  NGATC-TNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGF 358

Query: 1093 TSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFA 1152
               +      +SA  + C +G        PC    R    P+ G  +   CP  G + F 
Sbjct: 359  YGKI----CELSA--MTCADG--------PCFNGGRCSDSPDGG--YSCRCPV-GYSGFN 401

Query: 1153 GSRSITECSSFSSTFSAAEESVVPPASLGHIKK----RHEISSQVFHECFFNPCHNSGTC 1208
              + I  CSS S   + A+   +  A L   +     RH        +C  +PC N GTC
Sbjct: 402  CEKKIDYCSS-SPCSNGAKCVDLGDAYLCRCQAGFSGRH--CDDNVDDCASSPCANGGTC 458

Query: 1209 QQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEE 1268
            +     + C CP GYTG  C   +  C   PC N   C +    ++CEC  GY G  C+ 
Sbjct: 459  RDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQF 518

Query: 1269 NINECSSSPCL 1279
             + E    P +
Sbjct: 519  LLPELPPGPAV 529



 Score = 77.8 bits (190), Expect = 2e-13
 Identities = 39/114 (34%), Positives = 49/114 (42%), Gaps = 10/114 (8%)

Query: 3459 NGTWTSPPICRAVCRFPC-QNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAP 3517
            N  W  P     +C   C +  G C +P  C C  GW GR C+E I    CL+ G C  P
Sbjct: 213  NPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLH-GTCQQP 271

Query: 3518 YQCDCPPGWTGSRCHT----AVCQSPCLNGGKCVRPNR----CHCLSSWTGHNC 3563
            +QC+C  GW G  C+          PC NG  C    +    C C   +TG  C
Sbjct: 272  WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATC 325



 Score = 77.0 bits (188), Expect = 3e-13
 Identities = 39/105 (37%), Positives = 53/105 (50%), Gaps = 16/105 (15%)

Query: 3475 PCQNGGIC---QRPNACSCPEGWMGRLCEEPICIL---PCLNGGRCV----APYQCDCPP 3524
            PC+NGG C   +   +C+CP G+ G++CE         PC NGGRC       Y C CP 
Sbjct: 336  PCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPV 395

Query: 3525 GWTGSRCHTAV---CQSPCLNGGKCV---RPNRCHCLSSWTGHNC 3563
            G++G  C   +     SPC NG KCV       C C + ++G +C
Sbjct: 396  GYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHC 440



 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 39/116 (33%), Positives = 49/116 (42%), Gaps = 14/116 (12%)

Query: 3468 CRAVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPICIL----PCLNGGRCV----APYQ 3519
            C    R+P    G CQ+P  C+C EGW G  C + +       PC NG  C       Y 
Sbjct: 254  CDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYT 313

Query: 3520 CDCPPGWTGSRCHTAVCQ---SPCLNGGKCV---RPNRCHCLSSWTGHNCSRKRRT 3569
            C C PG+TG+ C   + +   SPC NGG C        C C   + G  C     T
Sbjct: 314  CSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMT 369



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 41/109 (37%), Positives = 50/109 (45%), Gaps = 17/109 (15%)

Query: 3475 PCQNGGIC----QRPNACSCPEGWMGRLCEEPICIL---PCLNGGRCVA---PYQCDCPP 3524
            PC+NG  C    Q    CSC  G+ G  CE  I      PC NGG C      Y C CPP
Sbjct: 297  PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPP 356

Query: 3525 GWTGSRCHTAV---CQSPCLNGGKCV-RPN---RCHCLSSWTGHNCSRK 3566
            G+ G  C  +       PC NGG+C   P+    C C   ++G NC +K
Sbjct: 357  GFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKK 405



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 43/106 (40%), Positives = 51/106 (48%), Gaps = 16/106 (15%)

Query: 3475 PCQNGGICQ-RPN---ACSCPEGWMGRLCEEPICIL---PCLNGGRCVA---PYQCDCPP 3524
            PC NGG C   P+   +C CP G+ G  CE+ I      PC NG +CV     Y C C  
Sbjct: 374  PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQA 433

Query: 3525 GWTGSRCHTAV---CQSPCLNGGKC---VRPNRCHCLSSWTGHNCS 3564
            G++G  C   V     SPC NGG C   V    C C   +TG NCS
Sbjct: 434  GFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCS 479



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 39/104 (37%), Positives = 49/104 (47%), Gaps = 15/104 (14%)

Query: 3475 PCQNGGICQRPN---ACSCPEGWMGRLCEEPI---CILPCLNGGRC---VAPYQCDCPPG 3525
            PC NG  C        C C  G+ GR C++ +      PC NGG C   V  + C CPPG
Sbjct: 413  PCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPG 472

Query: 3526 WTGSRCHTAVCQ---SPCLNGGKC-VRPNR--CHCLSSWTGHNC 3563
            +TG  C   V +   +PC NG  C  R +R  C C   + G NC
Sbjct: 473  YTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNC 516



 Score = 63.2 bits (152), Expect = 5e-09
 Identities = 29/77 (37%), Positives = 38/77 (49%), Gaps = 2/77 (2%)

Query: 3490 CPEGWMGRLCEEPICILPC-LNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVR 3548
            C  GW G  C EPIC+  C    G C  P +C C  GW G  C   +    CL+ G C +
Sbjct: 212  CNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLH-GTCQQ 270

Query: 3549 PNRCHCLSSWTGHNCSR 3565
            P +C+C   W G  C++
Sbjct: 271  PWQCNCQEGWGGLFCNQ 287



 Score = 40.8 bits (94), Expect = 0.024
 Identities = 34/109 (31%), Positives = 52/109 (47%), Gaps = 16/109 (14%)

Query: 1716 CNNGYYL--LGDSRMFCTDNGSWNGVSPSCLD-VDECAVGSDCSEHASCLNVDGSYICSC 1772
            C+NG     LGD+ + C     ++G    C D VD+CA  S C+   +C +    + C+C
Sbjct: 414  CSNGAKCVDLGDAYL-CRCQAGFSG--RHCDDNVDDCA-SSPCANGGTCRDGVNDFSCTC 469

Query: 1773 VPPYTGDGKNCAEPI-KCK-APGNPENGHSSGEIYTVGAEVTFSCQEGY 1819
             P YT  G+NC+ P+ +C+ AP      H+    +  G      C  GY
Sbjct: 470  PPGYT--GRNCSAPVSRCEHAP-----CHNGATCHERGHRYVCECARGY 511



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 34/146 (23%), Positives = 51/146 (34%), Gaps = 32/146 (21%)

Query: 267 GSFIQDDMVHCSYL--CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACP 324
           G F   D+ +C++   C  G  C +        T  G + C C  GY G   +       
Sbjct: 282 GLFCNQDLNYCTHHKPCKNGATCTN--------TGQGSYTCSCRPGYTGATCEL------ 327

Query: 325 SGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPP 384
                      GI  C P P +N  S     +   C C  G+   G+ CEL    A+   
Sbjct: 328 -----------GIDECDPSPCKNGGSCTDLENSYSCTCPPGF--YGKICEL---SAMTCA 371

Query: 385 ENGYFIQNTCNNHFNAACGVRCHPGF 410
           +   F    C++  +     RC  G+
Sbjct: 372 DGPCFNGGRCSDSPDGGYSCRCPVGY 397



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 35/136 (25%), Positives = 46/136 (33%), Gaps = 40/136 (29%)

Query: 281 CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSC 340
           CDE    CD+ G CKC             G+ G+             Y  E        C
Sbjct: 230 CDEQHGFCDKPGECKCRV-----------GWQGR-------------YCDE--------C 257

Query: 341 IPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNA 400
           I  P   H +      P  C C+EG+       +L +C   KP +NG    NT    +  
Sbjct: 258 IRYPGCLHGT---CQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTC 314

Query: 401 AC-----GVRCHPGFD 411
           +C     G  C  G D
Sbjct: 315 SCRPGYTGATCELGID 330



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 53/207 (25%), Positives = 67/207 (32%), Gaps = 49/207 (23%)

Query: 281 CDEGKDCCDRMGSCK----CGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGG 336
           C+ G D CD    CK    C      + C C  G+YGK  +     C  G     G    
Sbjct: 325 CELGIDECDP-SPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGR--- 380

Query: 337 ISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCE--LVHCPALKPPENGY------ 388
                 C D    SP G  S   C C  GY  SG  CE  + +C +  P  NG       
Sbjct: 381 ------CSD----SPDGGYS---CRCPVGY--SGFNCEKKIDYCSS-SPCSNGAKCVDLG 424

Query: 389 ----------FIQNTCNNHFNAACGVRCHPG---FDLVGSSIILCLPNGLWSGSESYCRV 435
                     F    C+++ +      C  G    D V      C P   ++G      V
Sbjct: 425 DAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPG--YTGRNCSAPV 482

Query: 436 RTCPHLRQPKHGHISCSTREMLYKTTC 462
             C H   P H   +C  R   Y   C
Sbjct: 483 SRCEH--APCHNGATCHERGHRYVCEC 507



 Score = 36.6 bits (83), Expect = 0.46
 Identities = 41/165 (24%), Positives = 57/165 (34%), Gaps = 28/165 (16%)

Query: 1716 CNNGYYLL--GDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCV 1773
            C NG      G     C+    + G +   L +DEC   S C    SC +++ SY C+C 
Sbjct: 298  CKNGATCTNTGQGSYTCSCRPGYTGATCE-LGIDECDP-SPCKNGGSCTDLENSYSCTCP 355

Query: 1774 PPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESG 1833
            P +   GK C       A G   NG    +    G   +  C  GY      K       
Sbjct: 356  PGFY--GKICELSAMTCADGPCFNGGRCSDSPDGG--YSCRCPVGYSGFNCEK------- 404

Query: 1834 EWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYT 1878
                 I YC +  C   A     C++      G     RC  G++
Sbjct: 405  ----KIDYCSSSPCSNGA----KCVD-----LGDAYLCRCQAGFS 436



 Score = 33.5 bits (75), Expect = 3.9
 Identities = 32/129 (24%), Positives = 51/129 (39%), Gaps = 30/129 (23%)

Query: 1693 PPPLENGFHSADDFYAGSTVTYQCNNGYY--LLGDSRMFCTDNGSWNGVSPSCLDVDE-- 1748
            P P +NG    D     ++ +  C  G+Y  +   S M C D   +NG    C D  +  
Sbjct: 334  PSPCKNGGSCTD---LENSYSCTCPPGFYGKICELSAMTCADGPCFNG--GRCSDSPDGG 388

Query: 1749 ----CAVG---------------SDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKC 1789
                C VG               S CS  A C+++  +Y+C C   ++  G++C + +  
Sbjct: 389  YSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFS--GRHCDDNVDD 446

Query: 1790 KAPGNPENG 1798
             A     NG
Sbjct: 447  CASSPCANG 455


>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
          Length = 3144

 Score =  235 bits (599), Expect = 7e-61
 Identities = 102/233 (43%), Positives = 138/233 (59%), Gaps = 7/233 (3%)

Query: 1195 HECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
            ++C  +PC +   C     GY CLC  GYTG+ CE ++DEC   PCL++GVC D +  + 
Sbjct: 968  NKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYT 1027

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
            C+C SG+ G  CE N N+C S+PCL+ G C + +  Y C+C        C+ ++N+C S 
Sbjct: 1028 CDCKSGFFGTHCETNANDCLSNPCLH-GRCTELINEYPCSCDADGTSTQCKIKINDCTSI 1086

Query: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECL-----SQPCKNGATCKDG-ANSFR 1368
            PC+N   C+    GF C CP G+ G  C K++D C      S  C NG  C DG  ++F 
Sbjct: 1087 PCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFD 1146

Query: 1369 CLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
            C C  GF+G  CE+NINEC S+PC + A C D +N Y CKCQPG+SG  CE E
Sbjct: 1147 CRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENE 1199



 Score =  217 bits (553), Expect = 1e-55
 Identities = 143/468 (30%), Positives = 205/468 (43%), Gaps = 50/468 (10%)

Query: 973  IADSNSLETKKASPFCRPGSV---LRG---RMCVNCPLGTYYNLEHFTCES--CRIGSYQ 1024
            I + ++ + K AS  C+ G+    LRG   R CV    GT   ++   C S  C+ G+  
Sbjct: 639  ICEIDTEDCKSAS--CKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATC 696

Query: 1025 -DEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGS 1083
             D+ G   C+  P          + +      C  G       +  + C           
Sbjct: 697  IDQPGNYFCQCVPP--------FKVVDGFSCLCNPGYVGIRCEQDIDDC----------- 737

Query: 1084 RSCLSCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPC--HPCPRDYYQPNAGKAFCL 1141
               L+  E+ ST K   ++     +   EG F       C  +PC  +    +  K++  
Sbjct: 738  --ILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRC 795

Query: 1142 ACPFYGTTPFAGSRSITECSS---------FSSTFSAAEESVVPPASLGHIKKRHEISSQ 1192
             C   G T    S  I EC S           ST       + PP   G    +      
Sbjct: 796  ECTS-GWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCD 854

Query: 1193 VFHECFFNPCHNSGTCQQL-GRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVG 1251
            + H    NPC N+ TC  L      C+C   + G  CE D+ +C  L C + G C+D+V 
Sbjct: 855  LLH----NPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVN 910

Query: 1252 EFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNEC 1311
             F C C  G++G  CE  INECSS PC N G CVD    + C C   + G  CE +VN+C
Sbjct: 911  NFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKC 970

Query: 1312 QSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLC 1371
            + +PCL+   C  +  G+ C C PG+ G  C  N+DECLS+PC +   C DG N + C C
Sbjct: 971  KISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDC 1030

Query: 1372 AAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
             +GF G+HCE N N+C SNPC +   C + +N Y C C    +  +C+
Sbjct: 1031 KSGFFGTHCETNANDCLSNPCLH-GRCTELINEYPCSCDADGTSTQCK 1077



 Score =  216 bits (549), Expect = 4e-55
 Identities = 101/272 (37%), Positives = 134/272 (49%), Gaps = 43/272 (15%)

Query: 1192 QVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKD--L 1249
            Q  +EC  NPC N+ TC  L + Y C C  G+TG  C  +I+EC   PC+N G+C +  +
Sbjct: 770  QESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTI 829

Query: 1250 VGEFICECPSGYTGQRCEENINECS--SSPCLNK-------------------------- 1281
             G+F+C CP  YTGQ C +  N C    +PC N                           
Sbjct: 830  PGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEI 889

Query: 1282 -------------GICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGG 1328
                         G C D V  +RC C  GF G  CE E+NEC S PC NN  C D    
Sbjct: 890  DVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNR 949

Query: 1329 FLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQ 1388
            F C C P + G  C  +V++C   PC +   C    + + CLCA G+TG +CE+N++EC 
Sbjct: 950  FFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECL 1009

Query: 1389 SNPCRNQATCVDELNSYSCKCQPGFSGKRCET 1420
            S PC +   C+D +N Y+C C+ GF G  CET
Sbjct: 1010 SEPCLHDGVCIDGINHYTCDCKSGFFGTHCET 1041



 Score =  214 bits (545), Expect = 1e-54
 Identities = 104/283 (36%), Positives = 137/283 (48%), Gaps = 57/283 (20%)

Query: 1196 ECFFNPCHNSGTC-QQLGR-------------GYVCLCPLGYTGLKCETDIDECSPLPCL 1241
            EC  +PC N  TC  Q G              G+ CLC  GY G++CE DID+C    C 
Sbjct: 684  ECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACE 743

Query: 1242 NNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVG 1301
            +N  CKDL   + C C S + G  CE+  NEC  +PC N   C D    YRC C  G+ G
Sbjct: 744  HNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTG 803

Query: 1302 LHCETEVNECQSNPCLNNAVCEDQV--GGFLCKCPPGFLGTRCGKNVDEC--LSQPCKNG 1357
             +C  E+NEC S+PC+N  +C +    G F+C CPP + G  C +  + C  L  PC+N 
Sbjct: 804  QNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNN 863

Query: 1358 ATC---------------------------------------KDGANSFRCLCAAGFTGS 1378
            +TC                                       +D  N+FRC+C  GF+GS
Sbjct: 864  STCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGS 923

Query: 1379 HCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
             CE+ INEC S PC+N  TCVD  N + C C+P + G  CE +
Sbjct: 924  LCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELD 966



 Score =  169 bits (428), Expect = 5e-41
 Identities = 83/238 (34%), Positives = 122/238 (51%), Gaps = 17/238 (7%)

Query: 1200 NPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLN-NGVCKDLVGEFICECP 1258
            N C +   C+       C C L Y G  C  ++D C     ++ +G+C  L     C   
Sbjct: 573  NECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGL 632

Query: 1259 SGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCT-CVKGFVGLHCETEVNECQSNPCL 1317
              Y    CE +  +C S+ C N G     + GY    CV GF G  CE +++EC S+PC 
Sbjct: 633  QRYERNICEIDTEDCKSASCKN-GTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCK 691

Query: 1318 NNAVCEDQVG--------------GFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDG 1363
            N A C DQ G              GF C C PG++G RC +++D+C+   C++ +TCKD 
Sbjct: 692  NGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDL 751

Query: 1364 ANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
              S++C+C + + G+ CE   NEC+ NPC+N +TC D   SY C+C  G++G+ C  E
Sbjct: 752  HLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEE 809



 Score =  164 bits (415), Expect = 1e-39
 Identities = 82/219 (37%), Positives = 113/219 (51%), Gaps = 23/219 (10%)

Query: 1195 HECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
            ++C  NPC + G C +L   Y C C    T  +C+  I++C+ +PC+N G C+     F 
Sbjct: 1044 NDCLSNPCLH-GRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFT 1102

Query: 1255 CECPSGYTGQRCEENINECS-----SSPCLNKGICVDGVAG-YRCTCVKGFVGLHCETEV 1308
            C CP GYTG  CE++I+ C+     S  CLN GICVDG    + C C+ GF G  CE  +
Sbjct: 1103 CICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEINI 1162

Query: 1309 NECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFR 1368
            NEC S+PCL+ A CED + G++CKC PG+ G  C +N  EC+   C +   C +      
Sbjct: 1163 NECSSSPCLHGADCEDHINGYVCKCQPGWSGHHC-ENELECIPNSCVH-ELCMENEPGST 1220

Query: 1369 CLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSC 1407
            CLC  GF                C     C DE+   +C
Sbjct: 1221 CLCTPGFM--------------TCSIGLLCGDEIRRITC 1245



 Score =  138 bits (348), Expect = 9e-32
 Identities = 77/246 (31%), Positives = 113/246 (45%), Gaps = 17/246 (6%)

Query: 1195 HECFFNPCHNSGTC--QQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGE 1252
            HE     C N  +C  ++  + Y  LC L + G     +  +     C +  VCKD +  
Sbjct: 528  HEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINR 587

Query: 1253 FICECPSGYTGQRCEENINECSSSPCLN-KGICVDGVAGYRCTCVKGFVGLHCETEVNEC 1311
              C C   Y G+ C  N++ C  +  ++  G+C+       C+ ++ +    CE +  +C
Sbjct: 588  PRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDC 647

Query: 1312 QSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDG-------- 1363
            +S  C N        G F  KC PGF GT+C  ++DEC S PCKNGATC D         
Sbjct: 648  KSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQC 707

Query: 1364 ------ANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKR 1417
                   + F CLC  G+ G  CE +I++C  N C + +TC D   SY C C   + G  
Sbjct: 708  VPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNF 767

Query: 1418 CETEQS 1423
            CE E +
Sbjct: 768  CEQESN 773



 Score =  134 bits (338), Expect = 1e-30
 Identities = 73/234 (31%), Positives = 101/234 (43%), Gaps = 7/234 (2%)

Query: 1192 QVFHECFFNPCHNSGTCQQLG-----RGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVC 1246
            Q    C F PC N+G+C         + Y C+C   +TG  C   I +C P  C +    
Sbjct: 212  QELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCS 271

Query: 1247 KDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCET 1306
                  FICEC   ++G  CE +   C S     +GIC +  + Y   C KG    + ET
Sbjct: 272  NITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGET 331

Query: 1307 EVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANS 1366
            +V+E    PC N   C       +C C P F    C      C S P +N ATCK     
Sbjct: 332  DVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKD 391

Query: 1367 FRCLCAAGFTGSHCELNINECQ--SNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
            + C C +GFT  +CE  I+ C+  S  C N+  C + +  +   C PG +   C
Sbjct: 392  YPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPC 445



 Score =  119 bits (298), Expect = 5e-26
 Identities = 67/225 (29%), Positives = 94/225 (41%), Gaps = 8/225 (3%)

Query: 1202 CHNSGTC--QQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGE-----FI 1254
            C   G C  +   + Y C C   ++G  C+ ++D CS  PC NNG C +         + 
Sbjct: 183  CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
            C C   +TG+ C E I +C    C +          + C C + F G  CE     C S 
Sbjct: 242  CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301

Query: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
                  +C +    +  +CP G        +V E    PC+NG  C   +N   C+C+  
Sbjct: 302  LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361

Query: 1375 FTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
            FT   C+     C+S P RN ATC      Y C C  GF+ K CE
Sbjct: 362  FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406



 Score = 75.9 bits (185), Expect = 7e-13
 Identities = 47/133 (35%), Positives = 61/133 (45%), Gaps = 22/133 (16%)

Query: 3456 CLENGTWTSPPICRAVCR-FPCQNGGICQRPN---ACSCPEGWMGRLCEEPI--CILP-- 3507
            C  +GT T   I    C   PC N G CQ+      C CP G+ G  CE+ I  C  P  
Sbjct: 1067 CDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPEL 1126

Query: 3508 ----CLNGGRCVA----PYQCDCPPGWTGSRCHTAVCQ---SPCLNGGKC---VRPNRCH 3553
                CLNGG CV      + C C PG++G  C   + +   SPCL+G  C   +    C 
Sbjct: 1127 NSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCK 1186

Query: 3554 CLSSWTGHNCSRK 3566
            C   W+GH+C  +
Sbjct: 1187 CQPGWSGHHCENE 1199



 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 53/202 (26%), Positives = 87/202 (43%), Gaps = 21/202 (10%)

Query: 1339 GTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATC 1398
            GT CG N        C+NG  C     +F C C   + G+ C  +++ C +N C +Q+ C
Sbjct: 2876 GTACGYNT-------CRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLC 2927

Query: 1399 V-DELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDGMLPSLHALTCTFWM 1457
            + D+  SYSC C  G+ G+ CE + S      F  +    Y+  +  + +L   T +  +
Sbjct: 2928 IPDQSFSYSCLCTLGWVGRYCENKTSFS-TAKFMGNSYIKYIDPNYRMRNLQFTTIS--L 2984

Query: 1458 KSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVL--YVNGREKITNCPSVNDG-----RW 1510
              S     G  +   +    +N  L    +   L   VN  E+I+   S N+G     +W
Sbjct: 2985 NFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLGERISVPMSYNNGTFCCNKW 3044

Query: 1511 HHIAITWTSANGIWKVYIDGKL 1532
            HH+ +       + K YI+  L
Sbjct: 3045 HHVVVIQNQT--LIKAYINNSL 3064



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 36/112 (32%), Positives = 52/112 (46%), Gaps = 6/112 (5%)

Query: 1329 FLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKD-----GANSFRCLCAAGFTGSHCELN 1383
            + C C P F G  C + +D C  +PCKN  +C +        ++ C+C   FTG +C   
Sbjct: 198  YSCHCQPPFSGKYC-QELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256

Query: 1384 INECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGI 1435
            I +CQ + C +        NS+ C+C   FSG  CE       +L F   GI
Sbjct: 257  IGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGI 308



 Score = 62.4 bits (150), Expect = 8e-09
 Identities = 35/109 (32%), Positives = 45/109 (41%), Gaps = 20/109 (18%)

Query: 3475 PCQNGGICQ---RPNACSCPEGWMGRLCEEPICIL---PCLNGGRC-----VAPYQCDCP 3523
            PC+N   C    +   C C  GW G+ C E I      PC+NGG C        + C CP
Sbjct: 779  PCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCP 838

Query: 3524 PGWTGSRCHTA-----VCQSPCLNGGKCV----RPNRCHCLSSWTGHNC 3563
            P +TG  CH       +  +PC N   C+        C C   + G NC
Sbjct: 839  PLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNC 887



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 50/164 (30%), Positives = 67/164 (40%), Gaps = 33/164 (20%)

Query: 3436 DMITYSCYSGYM---LEGFLRSVCLENGTWTSPPICRAVCR-FPCQNGGIC-QRPN---- 3486
            D  + SC +G     L G+    C+     T   I    C   PC+NG  C  +P     
Sbjct: 646  DCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFC 705

Query: 3487 ------------ACSCPEGWMGRLCEEPI--CIL-PCLNGGRCV---APYQCDCPPGWTG 3528
                        +C C  G++G  CE+ I  CIL  C +   C      YQC C   W G
Sbjct: 706  QCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEG 765

Query: 3529 SRCH--TAVCQ-SPCLNGGKCV---RPNRCHCLSSWTGHNCSRK 3566
            + C   +  C+ +PC N   C    +  RC C S WTG NCS +
Sbjct: 766  NFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEE 809



 Score = 57.4 bits (137), Expect = 3e-07
 Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 10/87 (11%)

Query: 1343 GKNVDECLSQPCK-----NGATCKDGANSFRCLCAAGFTGSHCELNINECQ-----SNPC 1392
            G++V +C + PC      NG TC +   S  C C  G+ GS C   ++ C       + C
Sbjct: 2603 GRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHC 2662

Query: 1393 RNQATCVDELNSYSCKCQPGFSGKRCE 1419
               ATC+   + Y+C C  G +G  CE
Sbjct: 2663 SRGATCISLPHGYTCFCPLGTTGIYCE 2689



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 37/104 (35%), Positives = 48/104 (46%), Gaps = 15/104 (14%)

Query: 3475 PCQNGGIC---QRPNACSCPEGWMGRLCEEPI--C-ILPCLNGGRCVAP---YQCDCPPG 3525
            PC+N G C        C+C   + G  CE  +  C I PCL+   CV     Y C C PG
Sbjct: 936  PCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPG 995

Query: 3526 WTGSRCHTAV--CQS-PCLNGGKC---VRPNRCHCLSSWTGHNC 3563
            +TG  C   +  C S PCL+ G C   +    C C S + G +C
Sbjct: 996  YTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHC 1039



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 37/105 (35%), Positives = 50/105 (47%), Gaps = 16/105 (15%)

Query: 3475 PCQNGGIC----QRPNACSCPEGWMGRLCEEPI--CI-LPCLNGGRC---VAPYQCDCPP 3524
            PC+N   C         C C E + G+ CE  +  C+ L C + G C   V  ++C C P
Sbjct: 859  PCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRP 918

Query: 3525 GWTGSRCHTAV--CQS-PCLNGGKCV-RPNR--CHCLSSWTGHNC 3563
            G++GS C   +  C S PC N G CV   NR  C+C   + G  C
Sbjct: 919  GFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFC 963



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 51/183 (27%), Positives = 69/183 (37%), Gaps = 43/183 (23%)

Query: 3397 TCNPDETWTQTSAK---CEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLR 3453
            +C+ D T TQ   K   C  I C         +  G   +     T  C  GY       
Sbjct: 1066 SCDADGTSTQCKIKINDCTSIPC---------MNEGFCQKSAHGFTCICPRGYT-----G 1111

Query: 3454 SVCLENGTWTSPPICRAVCRFPCQNGGICQRPNA----CSCPEGWMGRLCEEPI---CIL 3506
            + C ++    + P   +V    C NGGIC         C C  G+ G+ CE  I      
Sbjct: 1112 AYCEKSIDNCAEPELNSVI---CLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSS 1168

Query: 3507 PCLNGGRC---VAPYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRPNRC---HCLSSWTG 3560
            PCL+G  C   +  Y C C PGW+G  C          N  +C+ PN C    C+ +  G
Sbjct: 1169 PCLHGADCEDHINGYVCKCQPGWSGHHCE---------NELECI-PNSCVHELCMENEPG 1218

Query: 3561 HNC 3563
              C
Sbjct: 1219 STC 1221



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 26/76 (34%), Positives = 34/76 (44%), Gaps = 3/76 (3%)

Query: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVG-EFIC 1255
            C  + C N+GTC        C CP  Y+G  C+     C   PC N   C    G + +C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVC 2396

Query: 1256 ECPSGYTGQRCEENIN 1271
             CP G +G  C + IN
Sbjct: 2397 LCPYGRSGPLCTDAIN 2412



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 27/96 (28%), Positives = 35/96 (36%), Gaps = 5/96 (5%)

Query: 1181 GHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLP- 1239
            GH      +       C    C N GTC + G    C C  G+ G  C   +  C P   
Sbjct: 2598 GHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHD 2657

Query: 1240 ----CLNNGVCKDLVGEFICECPSGYTGQRCEENIN 1271
                C     C  L   + C CP G TG  CE+ ++
Sbjct: 2658 PPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALS 2693



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 23/76 (30%), Positives = 32/76 (42%), Gaps = 5/76 (6%)

Query: 1235 CSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSS-----PCLNKGICVDGVA 1289
            CS + C N G C +      C C +G+ G  C E ++ C         C     C+    
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPH 2673

Query: 1290 GYRCTCVKGFVGLHCE 1305
            GY C C  G  G++CE
Sbjct: 2674 GYTCFCPLGTTGIYCE 2689



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 24/82 (29%), Positives = 40/82 (48%), Gaps = 2/82 (2%)

Query: 1229 ETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICV-DG 1287
            + D   C    C N G C      F C C   + G  C ++++ C ++ CL++ +C+ D 
Sbjct: 2873 DCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQ 2931

Query: 1288 VAGYRCTCVKGFVGLHCETEVN 1309
               Y C C  G+VG +CE + +
Sbjct: 2932 SFSYSCLCTLGWVGRYCENKTS 2953



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 28/84 (33%), Positives = 39/84 (46%), Gaps = 8/84 (9%)

Query: 1341 RCGKNVDEC-----LSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQ 1395
            R GKN++ C         C+N  TC     +  C C   ++G  C+     C++NPC N 
Sbjct: 2326 RHGKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFA--SCENNPCGNG 2383

Query: 1396 ATCVDELNS-YSCKCQPGFSGKRC 1418
            ATCV +  +   C C  G SG  C
Sbjct: 2384 ATCVPKSGTDIVCLCPYGRSGPLC 2407



 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 25/84 (29%), Positives = 36/84 (42%), Gaps = 10/84 (11%)

Query: 1308 VNECQSNPCL-----NNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQ-----PCKNG 1357
            V +C ++PC      N   C +      C C  G+ G+ C + V  C  +      C  G
Sbjct: 2606 VGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRG 2665

Query: 1358 ATCKDGANSFRCLCAAGFTGSHCE 1381
            ATC    + + C C  G TG +CE
Sbjct: 2666 ATCISLPHGYTCFCPLGTTGIYCE 2689



 Score = 48.9 bits (115), Expect = 9e-05
 Identities = 29/80 (36%), Positives = 35/80 (43%), Gaps = 5/80 (6%)

Query: 1311 CQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATC--KDGANSFR 1368
            C  + C NN  C        C+CP  + G  C      C + PC NGATC  K G +   
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLC--QFASCENNPCGNGATCVPKSGTD-IV 2395

Query: 1369 CLCAAGFTGSHCELNINECQ 1388
            CLC  G +G  C   IN  Q
Sbjct: 2396 CLCPYGRSGPLCTDAINITQ 2415



 Score = 48.1 bits (113), Expect = 2e-04
 Identities = 24/84 (28%), Positives = 34/84 (40%), Gaps = 10/84 (11%)

Query: 1269 NINECSSSPCL-----NKGICVDGVAGYRCTCVKGFVGLHCETEVNECQ-----SNPCLN 1318
            ++ +C +SPC      N G C++      C C  G+ G  C   V+ C       + C  
Sbjct: 2605 SVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSR 2664

Query: 1319 NAVCEDQVGGFLCKCPPGFLGTRC 1342
             A C     G+ C CP G  G  C
Sbjct: 2665 GATCISLPHGYTCFCPLGTTGIYC 2688



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 50/189 (26%), Positives = 72/189 (38%), Gaps = 33/189 (17%)

Query: 3399 NPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLE 3458
            N  E W + + +C    C PP   +N          G    + C+ G        S   E
Sbjct: 230  NKRENWDEQAYECV---CHPPFTGKNCSEI-----IGQCQPHVCFHGNCSNITSNSFICE 281

Query: 3459 NGTWTSPPICRAVCRFPCQN-----GGICQRPNACS-----CPEGWMGRLCEEPIC---I 3505
                 S P C    + PC +      GIC  PN+ S     CP+G   +  E  +    +
Sbjct: 282  CDEQFSGPFCEVSAK-PCVSLLFWKRGIC--PNSSSAYTYECPKGSSSQNGETDVSEFSL 338

Query: 3506 LPCLNGGRCVA---PYQCDCPPGWTGSRCHT--AVCQS-PCLNGG---KCVRPNRCHCLS 3556
            +PC NG  C+       C C P +T   C +    C+S P  N     KC +   C C+S
Sbjct: 339  VPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCIS 398

Query: 3557 SWTGHNCSR 3565
             +T  NC +
Sbjct: 399  GFTEKNCEK 407



 Score = 45.8 bits (107), Expect = 8e-04
 Identities = 29/90 (32%), Positives = 41/90 (45%), Gaps = 11/90 (12%)

Query: 3488 CSCPEGWMGRLCEEPI--CIL-PCLNGGRCVAP---YQCDCPPGWTGSRCHTAV---CQS 3538
            C C  G+ G  CE  +  C+  PCL+ G C+     Y CDC  G+ G+ C T       +
Sbjct: 990  CLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSN 1049

Query: 3539 PCLNG--GKCVRPNRCHCLSSWTGHNCSRK 3566
            PCL+G   + +    C C +  T   C  K
Sbjct: 1050 PCLHGRCTELINEYPCSCDADGTSTQCKIK 1079



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 26/79 (32%), Positives = 33/79 (41%), Gaps = 3/79 (3%)

Query: 1235 CSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICV-DGVAGYRC 1293
            C+   C NNG C        CECP  Y+G+ C+     C ++PC N   CV        C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVC 2396

Query: 1294 TCVKGFVGLHCETEVNECQ 1312
             C  G  G  C   +N  Q
Sbjct: 2397 LCPYGRSGPLCTDAINITQ 2415



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 24/74 (32%), Positives = 29/74 (39%), Gaps = 14/74 (18%)

Query: 3476 CQNGGICQRPNA---CSCPEGWMGRLCEEPICILP--------CLNGGRCVA---PYQCD 3521
            C NGG C        C+C  GW G  C E +            C  G  C++    Y C 
Sbjct: 2619 CGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCF 2678

Query: 3522 CPPGWTGSRCHTAV 3535
            CP G TG  C  A+
Sbjct: 2679 CPLGTTGIYCEQAL 2692



 Score = 43.9 bits (102), Expect = 0.003
 Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 2/72 (2%)

Query: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVC-KDLVGEFIC 1255
            C +N C N G C   G  + C C   + G  C   +  C    CL+  +C  D    + C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYSC 2937

Query: 1256 ECPSGYTGQRCE 1267
             C  G+ G+ CE
Sbjct: 2938 LCTLGWVGRYCE 2949



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 15/83 (18%)

Query: 3497 RLCEEPICILPCLNGGRCVAP-----YQCDCPPGWTGSRCH--TAVCQSPCLNGGKCVRP 3549
            + C+E +    C   G+C++      Y C C P ++G  C    A    PC N G C+  
Sbjct: 172  QFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINK 231

Query: 3550 N--------RCHCLSSWTGHNCS 3564
                      C C   +TG NCS
Sbjct: 232  RENWDEQAYECVCHPPFTGKNCS 254



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 25/68 (36%), Positives = 31/68 (45%), Gaps = 8/68 (11%)

Query: 3476 CQNGGICQRPNA---CSCPEGWMGRLCEEPIC-ILPCLNGGRCV----APYQCDCPPGWT 3527
            C+N G C   N    C CP  + G+LC+   C   PC NG  CV        C CP G +
Sbjct: 2344 CRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRS 2403

Query: 3528 GSRCHTAV 3535
            G  C  A+
Sbjct: 2404 GPLCTDAI 2411



 Score = 43.1 bits (100), Expect = 0.005
 Identities = 21/68 (30%), Positives = 28/68 (41%), Gaps = 9/68 (13%)

Query: 3508 CLNGGRCVA---PYQCDCPPGWTGSRCHTAV--CQSPCLNGGKCVRPN----RCHCLSSW 3558
            C NGG C      + C C P W G+ C+ +V    + CL+   C+        C C   W
Sbjct: 2884 CRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGW 2943

Query: 3559 TGHNCSRK 3566
             G  C  K
Sbjct: 2944 VGRYCENK 2951



 Score = 42.7 bits (99), Expect = 0.006
 Identities = 18/41 (43%), Positives = 26/41 (63%), Gaps = 2/41 (4%)

Query: 1744 LDVDECAVGSDCSEHASCLNVDGSYICSCVPPY-TGDGKNC 1783
            +D+DECA    C   A+C++  G+Y C CVPP+   DG +C
Sbjct: 680  IDIDECA-SHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSC 719



 Score = 41.2 bits (95), Expect = 0.019
 Identities = 34/128 (26%), Positives = 45/128 (35%), Gaps = 19/128 (14%)

Query: 1112 EGKFSRSGLMPCHP-CPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITECSS-FSSTFSA 1169
            +G F   G    HP   R   Q +A     + C   GT   +G+     C++ +  +F  
Sbjct: 2587 DGHFRGLGNPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCT 2646

Query: 1170 AEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCE 1229
               S   P    H    H              C    TC  L  GY C CPLG TG+ CE
Sbjct: 2647 ETVSTCDPE---HDPPHH--------------CSRGATCISLPHGYTCFCPLGTTGIYCE 2689

Query: 1230 TDIDECSP 1237
              +    P
Sbjct: 2690 QALSISDP 2697



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 23/63 (36%), Positives = 33/63 (52%), Gaps = 4/63 (6%)

Query: 1717 NNGYYLLGDSRMFCTDNGSWNGVSPSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPP 1775
            NNG  +   +R FC     ++G  P C LDV++C + S C +  +C+     Y C C P 
Sbjct: 939  NNGTCVDLTNRFFCNCEPEYHG--PFCELDVNKCKI-SPCLDEENCVYRTDGYNCLCAPG 995

Query: 1776 YTG 1778
            YTG
Sbjct: 996  YTG 998



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 21/65 (32%), Positives = 27/65 (41%), Gaps = 9/65 (13%)

Query: 3476 CQNGGICQRPN---ACSCPEGWMGRLCEEPICILP--CLNGGRCVA----PYQCDCPPGW 3526
            C+NGG C       +C C   W G  C + +  L   CL+   C+      Y C C  GW
Sbjct: 2884 CRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGW 2943

Query: 3527 TGSRC 3531
             G  C
Sbjct: 2944 VGRYC 2948



 Score = 39.7 bits (91), Expect = 0.054
 Identities = 20/54 (37%), Positives = 28/54 (51%), Gaps = 5/54 (9%)

Query: 3499 CEEPICILP-CLNGGRCVAPYQ---CDCPPGWTGSRCHTAVCQ-SPCLNGGKCV 3547
            C  P C    C N G C++  +   C+CP  ++G  C  A C+ +PC NG  CV
Sbjct: 2334 CHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCV 2387



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 19/45 (42%), Positives = 22/45 (48%), Gaps = 1/45 (2%)

Query: 1194 FHECFFNPCHNSGTC-QQLGRGYVCLCPLGYTGLKCETDIDECSP 1237
            F  C  NPC N  TC  + G   VCLCP G +G  C   I+   P
Sbjct: 2372 FASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQP 2416



 Score = 37.7 bits (86), Expect = 0.21
 Identities = 23/85 (27%), Positives = 31/85 (36%), Gaps = 14/85 (16%)

Query: 3495 MGRLCEEPICILPCLNGGRCV---APYQCDCPPGWTGSRCHTAVCQSP--------CLNG 3543
            +G+    P  ++ C NGG C+       C+C  GW GS C   V            C  G
Sbjct: 2606 VGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRG 2665

Query: 3544 GKCV---RPNRCHCLSSWTGHNCSR 3565
              C+       C C    TG  C +
Sbjct: 2666 ATCISLPHGYTCFCPLGTTGIYCEQ 2690



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 19/50 (38%), Positives = 28/50 (56%), Gaps = 8/50 (16%)

Query: 1743 CLDVDECAVGSDCSEHASCLNV-----DGSYICSCVPPYTGDGKNCAEPI 1787
            C ++D C+    C  + SC+N      + +Y C C PP+T  GKNC+E I
Sbjct: 211  CQELDACSF-KPCKNNGSCINKRENWDEQAYECVCHPPFT--GKNCSEII 257



 Score = 35.8 bits (81), Expect = 0.78
 Identities = 49/218 (22%), Positives = 77/218 (35%), Gaps = 59/218 (27%)

Query: 267 GSFIQDDMVHC-SYLCDEGKDCCDRMGS--CKCGTH---TGHFECICEKGYYG------- 313
           G+  + D+  C S+ C  G  C D+ G+  C+C         F C+C  GY G       
Sbjct: 675 GTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDI 734

Query: 314 ----------------KGLQYECTACP--SGTYKPEGSPGGISSCIPCPDENHTSPPGST 355
                             L Y+C       G +  + S    + C   P +N+++     
Sbjct: 735 DDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQES----NECKMNPCKNNSTCTDLY 790

Query: 356 SPEDCVCREGYRASGQTC--ELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLV 413
               C C  G+  +GQ C  E+  C +           + C N      G  CH    + 
Sbjct: 791 KSYRCECTSGW--TGQNCSEEINECDS-----------DPCMN------GGLCHES-TIP 830

Query: 414 GSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISC 451
           G  + LC P  L++G   + R   C  L  P   + +C
Sbjct: 831 GQFVCLCPP--LYTGQFCHQRYNLCDLLHNPCRNNSTC 866



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 19/40 (47%), Positives = 21/40 (52%), Gaps = 5/40 (12%)

Query: 1197 CFFNPCHNSGTCQQ--LGRGYV---CLCPLGYTGLKCETD 1231
            C  + CHN GTC    L  G V   C CPL +TG  CE D
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD 2142



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 2/37 (5%)

Query: 1392 CRNQATCVDEL--NSYSCKCQPGFSGKRCETEQSTGF 1426
            C     C+ E    +YSC CQP FSGK C+   +  F
Sbjct: 183  CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSF 219



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 36/124 (29%), Positives = 51/124 (41%), Gaps = 21/124 (16%)

Query: 288  CDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDEN 347
            C   G C+   H   F CIC +GY G   +     C     +PE     ++S I      
Sbjct: 1088 CMNEGFCQKSAHG--FTCICPRGYTGAYCEKSIDNCA----EPE-----LNSVICLNGGI 1136

Query: 348  HTSPPGSTSPEDCVCREGYRASGQTCEL-VHCPALKPPENGYFIQNTCNNHFNAACGVRC 406
                PG T   DC C  G+  SGQ CE+ ++  +  P  +G      C +H N     +C
Sbjct: 1137 CVDGPGHTF--DCRCLPGF--SGQFCEININECSSSPCLHG----ADCEDHINGYV-CKC 1187

Query: 407  HPGF 410
             PG+
Sbjct: 1188 QPGW 1191



 Score = 34.7 bits (78), Expect = 1.7
 Identities = 12/33 (36%), Positives = 19/33 (57%)

Query: 1387 CQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
            C  + CRN  TC+ +  +  C+C   +SGK C+
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ 2371



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 43/195 (22%), Positives = 64/195 (32%), Gaps = 57/195 (29%)

Query: 234  MASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYL-CDEGKDCCDRMG 292
            +A     +HC     FE                G   + D+  C +L C +  DC D + 
Sbjct: 867  LALVDANQHCICREEFE----------------GKNCEIDVKDCLFLSCQDYGDCEDMV- 909

Query: 293  SCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISS------------- 339
                     +F CIC  G+ G   + E   C S   K  G+   +++             
Sbjct: 910  --------NNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGP 961

Query: 340  ----------CIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPP--ENG 387
                        PC DE +      T   +C+C  GY  +G  CE+     L  P   +G
Sbjct: 962  FCELDVNKCKISPCLDEENC--VYRTDGYNCLCAPGY--TGINCEINLDECLSEPCLHDG 1017

Query: 388  YFIQNTCNNHFNAAC 402
              I     NH+   C
Sbjct: 1018 VCIDGI--NHYTCDC 1030



 Score = 33.5 bits (75), Expect = 3.9
 Identities = 16/38 (42%), Positives = 17/38 (44%), Gaps = 5/38 (13%)

Query: 1349 CLSQPCKNGATC-----KDGANSFRCLCAAGFTGSHCE 1381
            C    C NG TC       G  SF+C C   FTG  CE
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCE 2140



 Score = 33.5 bits (75), Expect = 3.9
 Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 5/47 (10%)

Query: 1383 NINECQSNPCR-----NQATCVDELNSYSCKCQPGFSGKRCETEQST 1424
            ++ +C ++PC      N  TC++   S  C C  G+ G  C    ST
Sbjct: 2605 SVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVST 2651



 Score = 32.3 bits (72), Expect = 8.6
 Identities = 22/77 (28%), Positives = 33/77 (42%), Gaps = 18/77 (23%)

Query: 1713 TYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSC 1772
            T+ C     L G S  FC  N +    SP       C  G+DC +H +       Y+C C
Sbjct: 1144 TFDCR---CLPGFSGQFCEININECSSSP-------CLHGADCEDHIN------GYVCKC 1187

Query: 1773 VPPYTGDGKNCAEPIKC 1789
             P ++  G +C   ++C
Sbjct: 1188 QPGWS--GHHCENELEC 1202


>gi|112420992 crumbs homolog 2 [Homo sapiens]
          Length = 1285

 Score =  231 bits (589), Expect = 1e-59
 Identities = 107/248 (43%), Positives = 136/248 (54%), Gaps = 22/248 (8%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            EC   PCH+  TC+ L   Y C CPLGY G+ CE ++DEC+  PCL+ G C D VG F C
Sbjct: 111  ECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRC 170

Query: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCV-KGFVGLHCETEVNECQSN 1314
             C  GY G RC+ +++EC S PC + G C D V G+RC C   G+ G HCE EV EC S 
Sbjct: 171  VCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASA 230

Query: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKD------------ 1362
            PC +NA C + +G F C C PG+ G  C  + DEC S PC++G  C              
Sbjct: 231  PCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQA 290

Query: 1363 ---GANSFR------CLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGF 1413
               GA SFR      C C  GF G+ C + ++EC S PC N   C D  N + C C  G+
Sbjct: 291  AFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGY 350

Query: 1414 SGKRCETE 1421
            +G  CE +
Sbjct: 351  AGPTCEED 358



 Score =  223 bits (568), Expect = 3e-57
 Identities = 97/250 (38%), Positives = 136/250 (54%), Gaps = 25/250 (10%)

Query: 1197 CFFNPCHNSGTCQQLG---RGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEF 1253
            C   PCH+   C   G    G+ C C  G+ G +CE DIDEC+  PC +   C++L   +
Sbjct: 71   CATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRY 130

Query: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQS 1313
             C CP GY G  CE  ++EC+S+PCL+ G C+DGV  +RC C  G+ G  C+ +++ECQS
Sbjct: 131  ECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQS 190

Query: 1314 NPCLNNAVCEDQVGGFLCKCP-PGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCA 1372
             PC +   C D V GF C C   G+ GT C + V EC S PC++ A+C +G  SFRCLC 
Sbjct: 191  QPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCW 250

Query: 1373 AGFTGSHCELNINECQSNPCRNQATCVDELN---------------------SYSCKCQP 1411
             G++G  CE++ +EC S+PC++   C+   +                      + C C P
Sbjct: 251  PGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPP 310

Query: 1412 GFSGKRCETE 1421
            GF G  C  E
Sbjct: 311  GFEGADCGVE 320



 Score =  201 bits (511), Expect = 1e-50
 Identities = 101/259 (38%), Positives = 134/259 (51%), Gaps = 28/259 (10%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCP-LGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
            EC   PC + GTC  L  G+ C C   GY G  CE ++ EC+  PC +N  C + +G F 
Sbjct: 187  ECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFR 246

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVD--------GV-------------AGYRC 1293
            C C  GY+G+ CE + +EC+SSPC + G C+         GV             AG+ C
Sbjct: 247  CLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLC 306

Query: 1294 TCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQP 1353
             C  GF G  C  EV+EC S PCLN   C+D   GF C CP G+ G  C ++VDECLS P
Sbjct: 307  HCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDP 366

Query: 1354 CKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCV----DELNSYSCKC 1409
            C +G TC D    + C C   + G  C + +  CQ + C   ATC+      ++SY C C
Sbjct: 367  CLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHC 426

Query: 1410 QPGFSGKRCETEQSTGFNL 1428
             PG  G  C   Q+T F++
Sbjct: 427  PPGTHGPFC--GQNTTFSV 443



 Score =  148 bits (374), Expect = 8e-35
 Identities = 107/363 (29%), Positives = 151/363 (41%), Gaps = 58/363 (15%)

Query: 1020 IGSYQDEEGQLECKLCPSGMYTEYIHSRNISD-CKAQCKQGTYSYSGL------ETCESC 1072
            +  +Q    +L+   C S         RN++D  +  C  G   Y+G+      + C S 
Sbjct: 97   VPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLG---YAGVTCEMEVDECASA 153

Query: 1073 PL---GTYQPKFGSRSCLSCPENTSTVKRGAVNISAC-GVPCPEGKFSRSGLMPCHPCPR 1128
            P    G+     GS  C+  P    T  R  +++  C   PC  G         CH    
Sbjct: 154  PCLHGGSCLDGVGSFRCVCAPGYGGT--RCQLDLDECQSQPCAHGG-------TCHDLV- 203

Query: 1129 DYYQPNAGKAFCLACPFYGTTPFAGSRSITECSSFSSTFSAA-EESVVPPASLGHIKKRH 1187
                 N  +  C    + GT      R + EC+S     +A+  E +     L       
Sbjct: 204  -----NGFRCDCAGTGYEGTHC---EREVLECASAPCEHNASCLEGLGSFRCLCWPGYSG 255

Query: 1188 EISSQVFHECFFNPCHNSGTCQQLG---------------------RGYVCLCPLGYTGL 1226
            E+      EC  +PC + G C Q                        G++C CP G+ G 
Sbjct: 256  ELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGA 315

Query: 1227 KCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVD 1286
             C  ++DEC+  PCLN G C+DL   F C CP GY G  CEE+++EC S PCL+ G C D
Sbjct: 316  DCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSD 375

Query: 1287 GVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVC----EDQVGGFLCKCPPGFLGTRC 1342
             VAGY C C + + G  C  ++  CQ + C   A C    E  V  ++C CPPG  G  C
Sbjct: 376  TVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFC 435

Query: 1343 GKN 1345
            G+N
Sbjct: 436  GQN 438



 Score =  117 bits (294), Expect = 2e-25
 Identities = 59/161 (36%), Positives = 77/161 (47%), Gaps = 3/161 (1%)

Query: 1273 CSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCK 1332
            C+ SPCL+ G C D    + C C  G+ G  CE  V+ C S PC          G F C+
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119

Query: 1333 CPPGFLGTRCGKNV--DEC-LSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQS 1389
            CPPGF G RC   V   EC L+  C +G+ C+ G+ +  C C  G  G  C++    C++
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEA 1179

Query: 1390 NPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDF 1430
            NPC N  TC        C C   FSG+ CE  +     L F
Sbjct: 1180 NPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLPLPF 1220



 Score =  104 bits (259), Expect = 2e-21
 Identities = 50/149 (33%), Positives = 67/149 (44%), Gaps = 3/149 (2%)

Query: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICE 1256
            C  +PC + G C+ L   + C C  G+ G +CE  +D C   PC          G F C 
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119

Query: 1257 CPSGYTGQRCEENI--NECS-SSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQS 1313
            CP G+ G RC   +   ECS +  CL+   C  G     C+C++G  G  C+     C++
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEA 1179

Query: 1314 NPCLNNAVCEDQVGGFLCKCPPGFLGTRC 1342
            NPCLN   C    G   C C   F G  C
Sbjct: 1180 NPCLNGGTCRAAGGVSECICNARFSGQFC 1208



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 40/108 (37%), Positives = 55/108 (50%), Gaps = 16/108 (14%)

Query: 3475 PCQNGGICQR---PNACSCPEGWMGRLCEEPI---CILPCLNGGRC---VAPYQCDCPPG 3525
            PC +G  C+       C CP G+ G  CE  +      PCL+GG C   V  ++C C PG
Sbjct: 116  PCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPG 175

Query: 3526 WTGSRCHTAV--CQS-PCLNGGKC---VRPNRCHCL-SSWTGHNCSRK 3566
            + G+RC   +  CQS PC +GG C   V   RC C  + + G +C R+
Sbjct: 176  YGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCERE 223



 Score = 65.5 bits (158), Expect = 9e-10
 Identities = 37/115 (32%), Positives = 46/115 (40%), Gaps = 32/115 (27%)

Query: 1339 GTRCGKNVDECLSQPCKNGATCK-----------------------DGA---------NS 1366
            GT   +    C S PC  G  C+                        GA           
Sbjct: 32   GTVPSEPPSACASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTG 91

Query: 1367 FRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
            FRC C  GF G  CEL+I+EC S PC + ATC +  + Y C C  G++G  CE E
Sbjct: 92   FRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEME 146



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 43/110 (39%), Positives = 50/110 (45%), Gaps = 19/110 (17%)

Query: 3475 PCQNGGICQR-PNA--CSCPEGWMGRLCEEPI--CIL-PCLNGGRC---VAPYQCDCPPG 3525
            PC NGG CQ  PN   C CP+G+ G  CEE +  C+  PCL+GG C   VA Y C CP  
Sbjct: 328  PCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPET 387

Query: 3526 WTGSRCHTAV--CQS-PCLNGGKC-------VRPNRCHCLSSWTGHNCSR 3565
            W G  C   +  CQ   C     C       V    CHC     G  C +
Sbjct: 388  WGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQ 437



 Score = 61.2 bits (147), Expect = 2e-08
 Identities = 41/125 (32%), Positives = 52/125 (41%), Gaps = 36/125 (28%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCE---EPICILPCLNGGRCV------------- 3515
            PC++   C        C C  G+ G LCE   +     PC +GGRC+             
Sbjct: 231  PCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQA 290

Query: 3516 -----------APYQCDCPPGWTGSRCHTAV--CQS-PCLNGGKCV-RPN--RCHCLSSW 3558
                       A + C CPPG+ G+ C   V  C S PCLNGG C   PN  +CHC   +
Sbjct: 291  AFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGY 350

Query: 3559 TGHNC 3563
             G  C
Sbjct: 351  AGPTC 355



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 37/116 (31%), Positives = 47/116 (40%), Gaps = 21/116 (18%)

Query: 3466 PICRAVCRFPCQNGGICQR---PNACSCPEGWMGRLCE---EPICILPCLNGGRCVAP-- 3517
            P+C      PC + G C+      AC+C  GW G  CE   +P    PC  G     P  
Sbjct: 1058 PVCAPS---PCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDG 1114

Query: 3518 -YQCDCPPGWTGSRCHTAV------CQSPCLNGGKCVRPN---RCHCLSSWTGHNC 3563
             ++C CPPG+ G RC   V          CL+G  C   +    C CL    G  C
Sbjct: 1115 RFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRC 1170



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 107/459 (23%), Positives = 154/459 (33%), Gaps = 87/459 (18%)

Query: 1347 DECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYS 1406
            D C   PC NG TC    N F C C A FTG  C   +  C   PC   ATC +  + + 
Sbjct: 809  DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFV 867

Query: 1407 CKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDGMLPSLHALTCTFW-MKSSDDMNY 1465
            C  +  F  +       +G N     SG     +L G+  +        W ++++     
Sbjct: 868  CVAEATF--REGPPAAFSGHNAS---SG----RLLGGLSLAFRTRDSEAWLLRAAAGALE 918

Query: 1466 GTPISYAVDNGSDNTLLLTDYN--GWVLYVNGREKITNCPSVNDGRWHHIAITW---TSA 1520
            G  +  AV NGS    +   +   G VL + G       P V DG WH + +      + 
Sbjct: 919  G--VWLAVRNGSLAGGVRGGHGLPGAVLPIPG-------PRVADGAWHRVRLAMERPAAT 969

Query: 1521 NGIWKVYIDGKLSDGGAGLSVGLPIPGGGALVLGQEQDKKGEGFSPAESFVGSISQLNLW 1580
               W +++D      GA   V L    G A  LG  Q         AE+F G + ++ L 
Sbjct: 970  TSRWLLWLD------GAATPVAL---RGLASDLGFLQGPGAVRILLAENFTGCLGRVALG 1020

Query: 1581 DYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPRLGGSVPH 1640
               L   + +  A     E    +  +WP   + I+G          C   P        
Sbjct: 1021 GLPLPLARPRPGAAPGARE----HFASWPGTPAPILG----------CRGAP-------- 1058

Query: 1641 LRTASEDLKPGSKVNLF------CDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPP 1694
            +   S  L  G+  +LF      C PG                W  P        C   P
Sbjct: 1059 VCAPSPCLHDGACRDLFDAFACACGPG----------------WEGPRCEAHVDPCHSAP 1102

Query: 1695 PLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSD 1754
                  H+  D         +C  G+   G  R           ++ +CLD   C  GS 
Sbjct: 1103 CARGRCHTHPD----GRFECRCPPGF---GGPRCRLPVPSKECSLNVTCLDGSPCEGGSP 1155

Query: 1755 CSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPG 1793
             + + SCL       C  VP    +   C     C+A G
Sbjct: 1156 AA-NCSCLEGLAGQRCQ-VPTLPCEANPCLNGGTCRAAG 1192



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 24/67 (35%), Positives = 31/67 (46%), Gaps = 1/67 (1%)

Query: 1233 DECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYR 1292
            D CSP PC N G C     +F C CP+ +TG  C + +  C   PCL    C +   G+ 
Sbjct: 809  DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFV 867

Query: 1293 CTCVKGF 1299
            C     F
Sbjct: 868  CVAEATF 874



 Score = 53.1 bits (126), Expect = 5e-06
 Identities = 30/95 (31%), Positives = 41/95 (43%), Gaps = 7/95 (7%)

Query: 1237 PLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCV 1296
            PLP  N+    +L G       +G   +      + CS  PC N G C+     + CTC 
Sbjct: 781  PLPLDNSSQPSELGGRQSWNLTAGCVSE------DMCSPDPCFNGGTCLVTWNDFHCTCP 834

Query: 1297 KGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLC 1331
              F G  C  ++  C   PCL  A CE+   GF+C
Sbjct: 835  ANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVC 868



 Score = 52.4 bits (124), Expect = 8e-06
 Identities = 36/107 (33%), Positives = 46/107 (42%), Gaps = 18/107 (16%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPI----CIL--PCLNGGRCVA---PYQCDC 3522
            PC  G     P+    C CP G+ G  C  P+    C L   CL+G  C        C C
Sbjct: 1102 PCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSC 1161

Query: 3523 PPGWTGSRCH--TAVCQS-PCLNGGKCVRP---NRCHCLSSWTGHNC 3563
              G  G RC   T  C++ PCLNGG C      + C C + ++G  C
Sbjct: 1162 LEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFC 1208



 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 23/65 (35%), Positives = 30/65 (46%), Gaps = 1/65 (1%)

Query: 1311 CQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCL 1370
            C  +PC N   C      F C CP  F G  C + +  C  QPC   ATC++  + F C+
Sbjct: 811  CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCV 869

Query: 1371 CAAGF 1375
              A F
Sbjct: 870  AEATF 874



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 20/59 (33%), Positives = 28/59 (47%), Gaps = 1/59 (1%)

Query: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            C  +PC N GTC      + C CP  +TG  C   +  C   PCL    C+++   F+C
Sbjct: 811  CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVC 868



 Score = 41.6 bits (96), Expect = 0.014
 Identities = 18/45 (40%), Positives = 25/45 (55%), Gaps = 1/45 (2%)

Query: 1226 LKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENI 1270
            L CE   ++C PLPC++ G C DL   F C+C   + G  C + I
Sbjct: 601  LGCERR-EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644



 Score = 41.2 bits (95), Expect = 0.019
 Identities = 43/144 (29%), Positives = 55/144 (38%), Gaps = 14/144 (9%)

Query: 1105 ACGVPCPEGKFSRSGLMPCH--PCPRDYYQPNAGKAFCLACPFYGTTPFAGSRS-----I 1157
            ACG P  EG    + + PCH  PC R     +    F   CP      F G R       
Sbjct: 1081 ACG-PGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECRCP----PGFGGPRCRLPVPS 1135

Query: 1158 TECSSFSSTFSAAE-ESVVPPASLGHIKKRHEISSQV-FHECFFNPCHNSGTCQQLGRGY 1215
             ECS   +    +  E   P A+   ++       QV    C  NPC N GTC+  G   
Sbjct: 1136 KECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVS 1195

Query: 1216 VCLCPLGYTGLKCETDIDECSPLP 1239
             C+C   ++G  CE       PLP
Sbjct: 1196 ECICNARFSGQFCEVAKGLPLPLP 1219



 Score = 40.8 bits (94), Expect = 0.024
 Identities = 32/103 (31%), Positives = 40/103 (38%), Gaps = 19/103 (18%)

Query: 3475 PCQNGGICQRPNACSCPEGWMGRLCEEP--ICILPCLNGGRCVAP------YQCDCPPGW 3526
            PC  G  CQ   +     G M     EP      PC +G  CV        ++C C PG+
Sbjct: 46   PCAPGTECQATESGGYTCGPM-----EPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGF 100

Query: 3527 TGSRCHTAV--CQS-PCLNGGKC---VRPNRCHCLSSWTGHNC 3563
             G RC   +  C S PC +G  C        CHC   + G  C
Sbjct: 101  QGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTC 143



 Score = 40.8 bits (94), Expect = 0.024
 Identities = 24/66 (36%), Positives = 30/66 (45%), Gaps = 9/66 (13%)

Query: 3475 PCQNGGICQRPNACSCPEGWMGRLCEEPIC---ILPCLNGGRCVAP---YQCDCPPGWTG 3528
            PC+ G        CSC EG  G+ C+ P       PCLNGG C A     +C C   ++G
Sbjct: 1149 PCEGGSPAAN---CSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSG 1205

Query: 3529 SRCHTA 3534
              C  A
Sbjct: 1206 QFCEVA 1211



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 25/80 (31%), Positives = 35/80 (43%), Gaps = 16/80 (20%)

Query: 3507 PCLNGGRCVAP---YQCDCPPGWTGSRCHTAV-CQ-SPCLNGGKCVR-PNRCHCL----- 3555
            PC NGG C+     + C CP  +TG  C   + C   PCL    C   P+   C+     
Sbjct: 815  PCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLWCPGQPCLPPATCEEVPDGFVCVAEATF 874

Query: 3556 -----SSWTGHNCSRKRRTG 3570
                 ++++GHN S  R  G
Sbjct: 875  REGPPAAFSGHNASSGRLLG 894



 Score = 36.2 bits (82), Expect = 0.60
 Identities = 42/176 (23%), Positives = 58/176 (32%), Gaps = 42/176 (23%)

Query: 238 PKEEHCYLLHSFE------EFEALARRALHEDLPSGSFIQDDMVHC-----SYLCD-EGK 285
           P    CY +  F+      + +  A R  H      +       HC        C+ E  
Sbjct: 89  PTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVD 148

Query: 286 DC----CDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPS------GT-------- 327
           +C    C   GSC  G   G F C+C  GY G   Q +   C S      GT        
Sbjct: 149 ECASAPCLHGGSCLDGV--GSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGF 206

Query: 328 --------YKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCEL 375
                   Y+       +  C   P E++ S         C+C  GY  SG+ CE+
Sbjct: 207 RCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGY--SGELCEV 260



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 16/35 (45%), Positives = 21/35 (60%), Gaps = 1/35 (2%)

Query: 1744 LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778
            ++VDECA  + C    SCL+  GS+ C C P Y G
Sbjct: 145  MEVDECA-SAPCLHGGSCLDGVGSFRCVCAPGYGG 178



 Score = 34.7 bits (78), Expect = 1.7
 Identities = 48/209 (22%), Positives = 66/209 (31%), Gaps = 70/209 (33%)

Query: 1595 SCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDC-----------PRLGGSVPHLRT 1643
            SC E L     L WP +   +    ++D      S C           P L G V     
Sbjct: 237  SCLEGLGSFRCLCWPGYSGELC---EVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFP 293

Query: 1644 ASEDLKPGSKVNLFCDPGFQLVGNPVQY-------CLNQGQWTQPLPHCERISCGVPPPL 1696
             +   +  +     C PGF+     V+        CLN G       HC+         L
Sbjct: 294  GAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGG-------HCQ--------DL 338

Query: 1697 ENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCL-DVDECAVGSDC 1755
             NGF               C +GY                    P+C  DVDEC +   C
Sbjct: 339  PNGFQC------------HCPDGY------------------AGPTCEEDVDEC-LSDPC 367

Query: 1756 SEHASCLNVDGSYICSCVPPYTGDGKNCA 1784
                +C +    YIC C    T  G++C+
Sbjct: 368  LHGGTCSDTVAGYICRCPE--TWGGRDCS 394



 Score = 34.7 bits (78), Expect = 1.7
 Identities = 31/106 (29%), Positives = 42/106 (39%), Gaps = 27/106 (25%)

Query: 295  KCGTHT-GHFECICEKGYYGKGLQY-----ECT---ACPSGTYKPEGSPGGISSC----- 340
            +C TH  G FEC C  G+ G   +      EC+    C  G+    GSP    SC     
Sbjct: 1107 RCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLA 1166

Query: 341  --------IPC---PDENHTSPPGSTSPEDCVCREGYRASGQTCEL 375
                    +PC   P  N  +   +    +C+C    R SGQ CE+
Sbjct: 1167 GQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNA--RFSGQFCEV 1210



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 16/35 (45%), Positives = 22/35 (62%), Gaps = 1/35 (2%)

Query: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGD 1779
            +V ECA  + C  +ASCL   GS+ C C P Y+G+
Sbjct: 223  EVLECA-SAPCEHNASCLEGLGSFRCLCWPGYSGE 256



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 14/41 (34%), Positives = 20/41 (48%)

Query: 1268 ENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEV 1308
            E   +C   PC++ G CVD    +RC C +   G  C  E+
Sbjct: 604  ERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644



 Score = 33.1 bits (74), Expect = 5.1
 Identities = 17/39 (43%), Positives = 20/39 (51%), Gaps = 2/39 (5%)

Query: 1741 PSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778
            P C LD+DECA    C   A+C N+   Y C C   Y G
Sbjct: 103  PRCELDIDECA-SRPCHHGATCRNLADRYECHCPLGYAG 140



 Score = 32.7 bits (73), Expect = 6.6
 Identities = 41/161 (25%), Positives = 49/161 (30%), Gaps = 41/161 (25%)

Query: 229 RELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHC-SYLCDEGKDC 287
           RE+ + AS P E +   L     F  L          SG   + D   C S  C  G  C
Sbjct: 222 REVLECASAPCEHNASCLEGLGSFRCLCWPGY-----SGELCEVDEDECASSPCQHGGRC 276

Query: 288 CDRMGSCKCG------------THTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPG 335
             R      G             H   F C C  G+ G     E   C S          
Sbjct: 277 LQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASR--------- 327

Query: 336 GISSCIPCPDENHTS--PPGSTSPEDCVCREGYRASGQTCE 374
                 PC +  H    P G      C C +GY  +G TCE
Sbjct: 328 ------PCLNGGHCQDLPNGF----QCHCPDGY--AGPTCE 356


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score =  225 bits (574), Expect = 5e-58
 Identities = 97/223 (43%), Positives = 132/223 (59%), Gaps = 2/223 (0%)

Query: 1200 NPCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECP 1258
            +PC N GTC       Y C CP GY+G  CE     C+  PC N G C ++   F C CP
Sbjct: 315  HPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCP 374

Query: 1259 SGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLN 1318
            SG++G  C  +I+EC+S+PC   G CVD V G+ C C + +VG  C+ + NEC+  PCLN
Sbjct: 375  SGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLN 434

Query: 1319 NAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGS 1378
               C++ +GG+ C C PG+ G  C  NV++C  Q C++G TCKD  N ++C+C  GF G 
Sbjct: 435  AFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGR 493

Query: 1379 HCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
            HCEL  +EC S+PC +   C D  + + C C  GFSG  CE +
Sbjct: 494  HCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVD 536



 Score =  224 bits (571), Expect = 1e-57
 Identities = 94/224 (41%), Positives = 126/224 (56%), Gaps = 1/224 (0%)

Query: 1195 HECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
            H C  NPC N G+C ++  G+ C CP G++G  C  DIDEC+  PC   G C D V  F 
Sbjct: 349  HACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFE 408

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
            C CP  + G  C+ + NEC   PCLN   C + + GY C C+ G+ G++C   VN+C+  
Sbjct: 409  CICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ 468

Query: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
             C +   C+D V G+ C CP GF G  C    DEC S PC +G  C+D A+ F C C  G
Sbjct: 469  -CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQG 527

Query: 1375 FTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
            F+G  CE++++ C+ +PCRN A C +    Y C C   F GK C
Sbjct: 528  FSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 571



 Score =  223 bits (569), Expect = 2e-57
 Identities = 144/441 (32%), Positives = 188/441 (42%), Gaps = 69/441 (15%)

Query: 993  VLRGRMCVNCPLG---TYYNLEHFTCES--CRIGSY-QDEEGQLECKLCPSGMYTEYIHS 1046
            ++ G  CV CP G    +  LE   C S  C  G   +D      C  CP G ++  +  
Sbjct: 478  LVNGYQCV-CPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCH-CPQG-FSGPLCE 534

Query: 1047 RNISDCK-AQCKQGT--YSYSGLETCESCPLGTYQPKFGSRSCL----SCPENTSTVKRG 1099
             ++  C+ + C+ G   Y+  G   C +CP       FG ++C      CP     V   
Sbjct: 535  VDVDLCEPSPCRNGARCYNLEGDYYC-ACP-----DDFGGKNCSVPREPCPGGACRV--- 585

Query: 1100 AVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITE 1159
               I  CG     G    +    C P  R   QP  G  F   C                
Sbjct: 586  ---IDGCGSDAGPGMPGTAASGVCGPHGRCVSQP--GGNFSCICD--------------- 625

Query: 1160 CSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLC 1219
             S F+ T+                   HE       +C   PC N GTC      + C C
Sbjct: 626  -SGFTGTYC------------------HEN----IDDCLGQPCRNGGTCIDEVDAFRCFC 662

Query: 1220 PLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCL 1279
            P G+ G  C+T+ ++C P PC + G C DLV +F C C  G+ G+ C     +C +  C 
Sbjct: 663  PSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCS 722

Query: 1280 NKGICVDGVAGYRCTCVKGFVGLHCETEVNE-CQSNPCLNNAVCEDQVGGFLCKCPPGFL 1338
            N G C D    +RC C  G+ G  C    N  C  NPC+N   C      F C C  G+ 
Sbjct: 723  NGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE 782

Query: 1339 GTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATC 1398
            G  C  N ++C   PC NG  C DG N FRC CA GF G  C +NI+ECQS+PC   ATC
Sbjct: 783  GRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATC 842

Query: 1399 VDELNSYSCKCQPGFSGKRCE 1419
            VDE+N Y C C PG +G RC+
Sbjct: 843  VDEINGYRCSCPPGRAGPRCQ 863



 Score =  194 bits (492), Expect = 2e-48
 Identities = 92/247 (37%), Positives = 121/247 (48%), Gaps = 25/247 (10%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            EC  NPC   GTC     G+ C+CP  + G  C+ D +EC   PCLN   CK+L+G + C
Sbjct: 388  ECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYC 447

Query: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP 1315
            +C  G+ G  C  N+N+C    C + G C D V GY+C C +GF G HCE E +EC S+P
Sbjct: 448  DCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSP 506

Query: 1316 CLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGF 1375
            C +  +CED   GF C CP GF G  C  +VD C   PC+NGA C +    + C C   F
Sbjct: 507  CHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDF 566

Query: 1376 TGSHCELNINECQSNPCR-----------------------NQATCVDEL-NSYSCKCQP 1411
             G +C +    C    CR                           CV +   ++SC C  
Sbjct: 567  GGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDS 626

Query: 1412 GFSGKRC 1418
            GF+G  C
Sbjct: 627  GFTGTYC 633



 Score =  188 bits (478), Expect = 7e-47
 Identities = 83/253 (32%), Positives = 115/253 (45%), Gaps = 24/253 (9%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            EC  +PCH+ G C+ L  G+ C CP G++G  CE D+D C P PC N   C +L G++ C
Sbjct: 501  ECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYC 560

Query: 1256 ECPSGYTGQRCEENINECSSSPCL------------NKGICVDGVAG------------Y 1291
             CP  + G+ C      C    C               G    GV G            +
Sbjct: 561  ACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNF 620

Query: 1292 RCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLS 1351
             C C  GF G +C   +++C   PC N   C D+V  F C CP G+ G  C  N ++CL 
Sbjct: 621  SCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 680

Query: 1352 QPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQP 1411
             PC +   C D  N F C C  G+ G  C     +C +  C N  TC D  +++ C C P
Sbjct: 681  DPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPP 740

Query: 1412 GFSGKRCETEQST 1424
            G+ G  C   +++
Sbjct: 741  GWKGSTCAVAKNS 753



 Score =  188 bits (477), Expect = 9e-47
 Identities = 85/229 (37%), Positives = 127/229 (55%), Gaps = 6/229 (2%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDEC-SPLPCLNNGVCKDLV-GEF 1253
            EC   P    G+C +    + C C   + GL C+ D++ C S  PC N G C +    ++
Sbjct: 275  ECVPYPGCVHGSCVE---PWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQY 331

Query: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQS 1313
             C CP GY+G+ CE+  + C+S+PC N G C +  +G+ C C  G+ G  C  +++EC S
Sbjct: 332  RCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECAS 391

Query: 1314 NPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAA 1373
            NPC     C DQV GF C CP  ++G  C  + +EC  +PC N  +CK+    + C C  
Sbjct: 392  NPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIP 451

Query: 1374 GFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQ 1422
            G+ G +C +N+N+C+   C++  TC D +N Y C C  GF G+ CE E+
Sbjct: 452  GWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELER 499



 Score =  153 bits (387), Expect = 3e-36
 Identities = 82/245 (33%), Positives = 113/245 (46%), Gaps = 41/245 (16%)

Query: 1207 TCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRC 1266
            TC Q G      C  G+ G +C+  +  C     L +G C  + GE  C C  G+ G+ C
Sbjct: 222  TCDQYGNK---ACMDGWMGKECKEAV--CKQGCNLLHGGCT-VPGE--CRCSYGWQGRFC 273

Query: 1267 EE-------------------------------NINECSS-SPCLNKGICVDGVAG-YRC 1293
            +E                               ++N C S  PC N G C++     YRC
Sbjct: 274  DECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRC 333

Query: 1294 TCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQP 1353
            TC  G+ G +CE   + C SNPC N   C +   GF C CP G+ G  C  ++DEC S P
Sbjct: 334  TCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP 393

Query: 1354 CKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGF 1413
            C  G TC D  + F C+C   + G+ C+L+ NEC+  PC N  +C + +  Y C C PG+
Sbjct: 394  CAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGW 453

Query: 1414 SGKRC 1418
             G  C
Sbjct: 454  KGINC 458



 Score = 82.8 bits (203), Expect = 6e-15
 Identities = 98/374 (26%), Positives = 134/374 (35%), Gaps = 42/374 (11%)

Query: 1028 GQLECKLCPSGMYTEYIHSRNISDCKAQ-CKQGTYSYSGLETCES-CPLGTYQPKFGSR- 1084
            G   C +C SG    Y H  NI DC  Q C+ G      ++     CP G       +  
Sbjct: 618  GNFSC-ICDSGFTGTYCHE-NIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNP 675

Query: 1085 -SCLSCPENTSTVKRGAVNISACGVPCPEGK-----FSRSGLMPCHPCPRDYYQPNAGKA 1138
              CL  P ++       VN   C   C +G       SR      + C       ++G  
Sbjct: 676  NDCLPDPCHSRGRCYDLVNDFYCA--CDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT 733

Query: 1139 FCLACP--FYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFH- 1195
            F  ACP  + G+T      S    S   +        V   AS   I +         H 
Sbjct: 734  FRCACPPGWKGSTCAVAKNS----SCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN 789

Query: 1196 --ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEF 1253
              +C   PC+N G C      + C C  G+ G  C  +IDEC   PC     C D +  +
Sbjct: 790  TNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY 849

Query: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGY-----RCTCVKGFVGLHCETEV 1308
             C CP G  G RC+E I    S  C ++G      + +      C C+ G      +   
Sbjct: 850  RCSCPPGRAGPRCQEVIGFGRS--CWSRGTPFPHGSSWVEDCNSCRCLDG----RRDCSK 903

Query: 1309 NECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRC-GKNVDECLSQPCKNGATC-KDGANS 1366
              C   PCL       Q      +CP   LG RC  K   +CL  PC+    C  +   S
Sbjct: 904  VWCGWKPCL----LAGQPEALSAQCP---LGQRCLEKAPGQCLRPPCEAWGECGAEEPPS 956

Query: 1367 FRCLCAAGFTGSHC 1380
              CL  +G   ++C
Sbjct: 957  TPCLPRSGHLDNNC 970



 Score = 82.4 bits (202), Expect = 7e-15
 Identities = 44/133 (33%), Positives = 62/133 (46%), Gaps = 14/133 (10%)

Query: 3443 YSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQ--NGGICQRPNACSCPEGWMGRLCE 3500
            +  Y  + +    C++   W       AVC+  C   +GG C  P  C C  GW GR C+
Sbjct: 218  FGHYTCDQYGNKACMDG--WMGKECKEAVCKQGCNLLHGG-CTVPGECRCSYGWQGRFCD 274

Query: 3501 EPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAV--CQS--PCLNGGKCVRPN----RC 3552
            E +    C++G  CV P+QC+C   W G  C   +  C S  PC NGG C+       RC
Sbjct: 275  ECVPYPGCVHGS-CVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRC 333

Query: 3553 HCLSSWTGHNCSR 3565
             C   ++G NC +
Sbjct: 334  TCPDGYSGRNCEK 346



 Score = 80.1 bits (196), Expect = 4e-14
 Identities = 56/167 (33%), Positives = 74/167 (44%), Gaps = 36/167 (21%)

Query: 3431 HY---QYGDMITYSCYSGYMLEGFLRSVC-----LENGTWTSPPICRA-----------V 3471
            HY   QYG+    +C  G+M +    +VC     L +G  T P  CR             
Sbjct: 220  HYTCDQYGNK---ACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDEC 276

Query: 3472 CRFPCQNGGICQRPNACSCPEGWMGRLCEEPICIL----PCLNGGRCVAP----YQCDCP 3523
              +P    G C  P  C+C   W G LC++ +       PC NGG C+      Y+C CP
Sbjct: 277  VPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP 336

Query: 3524 PGWTGSRCHTA--VCQS-PCLNGGKCVR-PN--RCHCLSSWTGHNCS 3564
             G++G  C  A   C S PC NGG C   P+   CHC S W+G  C+
Sbjct: 337  DGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCA 383



 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 40/105 (38%), Positives = 49/105 (46%), Gaps = 16/105 (15%)

Query: 3475 PCQNGGICQRPNA----CSCPEGWMGRLCE--EPICIL-PCLNGGRC---VAPYQCDCPP 3524
            PC NGG C         C+CP+G+ GR CE  E  C   PC NGG C    + ++C CP 
Sbjct: 316  PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPS 375

Query: 3525 GWTGSRCHTAV---CQSPCLNGGKCVRP---NRCHCLSSWTGHNC 3563
            GW+G  C   +     +PC  GG CV       C C   W G  C
Sbjct: 376  GWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420



 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 37/106 (34%), Positives = 49/106 (46%), Gaps = 16/106 (15%)

Query: 3475 PCQNGGICQ---RPNACSCPEGWMGRLC---EEPICILPCLNGGRCVAP---YQCDCPPG 3525
            PC + G C        C+C +GW G+ C   E       C NGG C      ++C CPPG
Sbjct: 682  PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPG 741

Query: 3526 WTGSRC----HTAVCQSPCLNGGKCVRPN---RCHCLSSWTGHNCS 3564
            W GS C    +++   +PC+NGG CV       C C   W G  C+
Sbjct: 742  WKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCT 787



 Score = 69.3 bits (168), Expect = 6e-11
 Identities = 39/107 (36%), Positives = 48/107 (44%), Gaps = 14/107 (13%)

Query: 3475 PCQNGGICQRPN---ACSCPEGWMGRLCEEPICIL---PCLNGGRC---VAPYQCDCPPG 3525
            PC  GG C        C CPE W+G  C+         PCLN   C   +  Y CDC PG
Sbjct: 393  PCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPG 452

Query: 3526 WTGSRCHTAV--CQSPCLNGGKC---VRPNRCHCLSSWTGHNCSRKR 3567
            W G  CH  V  C+  C +GG C   V   +C C   + G +C  +R
Sbjct: 453  WKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELER 499



 Score = 69.3 bits (168), Expect = 6e-11
 Identities = 56/184 (30%), Positives = 67/184 (36%), Gaps = 37/184 (20%)

Query: 3398 CNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSC---YSGYMLEGFLRS 3454
            C  D+ W   +    +  C            G  Y  GD    +C   + G        S
Sbjct: 698  CACDDGWKGKTCHSREFQCD----AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNS 753

Query: 3455 VCLENGTWTSPPICRAVCRFPCQNGGICQRPNA---CSCPEGWMGRLCEEPI--CI-LPC 3508
             CL N               PC NGG C    A   C C +GW GR C      C  LPC
Sbjct: 754  SCLPN---------------PCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC 798

Query: 3509 LNGGRCVAP---YQCDCPPGWTGSRCHTAV--CQ-SPCLNGGKCV---RPNRCHCLSSWT 3559
             NGG CV     ++C+C PG+ G  C   +  CQ SPC  G  CV      RC C     
Sbjct: 799  YNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRA 858

Query: 3560 GHNC 3563
            G  C
Sbjct: 859  GPRC 862



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 41/111 (36%), Positives = 52/111 (46%), Gaps = 15/111 (13%)

Query: 3472 CRFPCQNGGICQ---RPNACSCPEGWMGRLCE---EPICILPCLNGGRC---VAPYQCDC 3522
            CR  CQ+GG C+       C CP G+ GR CE   +     PC +GG C      + C C
Sbjct: 465  CRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHC 524

Query: 3523 PPGWTGSRCHTAV--CQ-SPCLNGGKCVR---PNRCHCLSSWTGHNCSRKR 3567
            P G++G  C   V  C+ SPC NG +C        C C   + G NCS  R
Sbjct: 525  PQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPR 575



 Score = 58.9 bits (141), Expect = 9e-08
 Identities = 33/89 (37%), Positives = 40/89 (44%), Gaps = 12/89 (13%)

Query: 3487 ACSCPEGWMGRLCEEPI--CI-LPCLNGGRC---VAPYQCDCPPGWTGSRCHT---AVCQ 3537
            +C C  G+ G  C E I  C+  PC NGG C   V  ++C CP GW G  C T       
Sbjct: 621  SCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 680

Query: 3538 SPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
             PC + G+C   V    C C   W G  C
Sbjct: 681  DPCHSRGRCYDLVNDFYCACDDGWKGKTC 709



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 47/167 (28%), Positives = 61/167 (36%), Gaps = 47/167 (28%)

Query: 3442 CYSGYMLEGFLRSVCLENGTWTSPPICRA---VCR-FPCQNGGICQRPNA---CSCPEGW 3494
            C+SG + E              S P+C     +C   PC+NG  C        C+CP+ +
Sbjct: 507  CHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDF 566

Query: 3495 MGRLCEEPICILPCLNG----------------------------GRCVAP----YQCDC 3522
             G+ C  P    PC  G                            GRCV+     + C C
Sbjct: 567  GGKNCSVPR--EPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCIC 624

Query: 3523 PPGWTGSRCHTAV---CQSPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
              G+TG+ CH  +      PC NGG C   V   RC C S W G  C
Sbjct: 625  DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 671



 Score = 56.2 bits (134), Expect = 6e-07
 Identities = 31/81 (38%), Positives = 41/81 (50%), Gaps = 12/81 (14%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPICIL---PCLNGGRCV---APYQCDCPPG 3525
            PC +GG+C+       C CP+G+ G LCE  + +    PC NG RC      Y C CP  
Sbjct: 506  PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 565

Query: 3526 WTGSRCHTAVCQSPCLNGGKC 3546
            + G  C  +V + PC  GG C
Sbjct: 566  FGGKNC--SVPREPC-PGGAC 583



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 41/142 (28%), Positives = 54/142 (38%), Gaps = 17/142 (11%)

Query: 273 DMVHCSYL-CDEG---KDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTY 328
           D+V+  Y  CD+G   K C  R   C   T +    C      Y  G  + C ACP G  
Sbjct: 691 DLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTC------YDSGDTFRC-ACPPGWK 743

Query: 329 KPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGY 388
               +    SSC+P P  N  +  GS +   C+CR+G+     T     C  L     G 
Sbjct: 744 GSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGI 803

Query: 389 FIQNTCNNHFNAACGVRCHPGF 410
            +     N F   C     PGF
Sbjct: 804 CVDGV--NWFRCECA----PGF 819



 Score = 39.7 bits (91), Expect = 0.054
 Identities = 47/193 (24%), Positives = 68/193 (35%), Gaps = 19/193 (9%)

Query: 280 LCDEGKDCCDRMGSCKCG-----THTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSP 334
           LCD+  + C     C  G          + C C  GY G+  +    AC S      GS 
Sbjct: 303 LCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSC 362

Query: 335 GGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTC--ELVHCPALKPPENGYFIQN 392
             + S   C   +  S P      D  C     A+G TC  ++     + P +   ++  
Sbjct: 363 HEVPSGFECHCPSGWSGPTCALDID-ECASNPCAAGGTCVDQVDGFECICPEQ---WVGA 418

Query: 393 TCNNHFNAACGVRCHPGF---DLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHI 449
           TC    N   G  C   F   +L+G     C+P   W G   +  V  C    Q +HG  
Sbjct: 419 TCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPG--WKGINCHINVNDC--RGQCQHGG- 473

Query: 450 SCSTREMLYKTTC 462
           +C      Y+  C
Sbjct: 474 TCKDLVNGYQCVC 486



 Score = 39.3 bits (90), Expect = 0.071
 Identities = 63/281 (22%), Positives = 93/281 (33%), Gaps = 30/281 (10%)

Query: 260 LHEDLPSGSFIQDDMVHCSYLCDEGKDCCDRM---GSCKCGTHTGHFECICEKGYYGKGL 316
           L EDL  G            LC+   D C+        +C    G + C C   + GK  
Sbjct: 512 LCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 571

Query: 317 QYECTACPSGTYK---------PEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYR 367
                 CP G  +           G PG  +S +  P     S PG      C+C  G+ 
Sbjct: 572 SVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNF--SCICDSGF- 628

Query: 368 ASGQTC-ELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGF--DLVGSSIILCLPNG 424
            +G  C E +     +P  NG     TC +  + A    C  G+  +L  ++   CLP+ 
Sbjct: 629 -TGTYCHENIDDCLGQPCRNG----GTCIDEVD-AFRCFCPSGWEGELCDTNPNDCLPDP 682

Query: 425 LWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNS 484
             S    Y  V              +C +RE  ++       + G   +  D   C    
Sbjct: 683 CHSRGRCYDLVNDFYCACDDGWKGKTCHSRE--FQCDAYTCSNGGTCYDSGDTFRCACPP 740

Query: 485 QWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTIC 525
            W G     V ++ S    P    ++   C    A F  IC
Sbjct: 741 GWKG-STCAVAKNSSCLPNP---CVNGGTCVGSGASFSCIC 777



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 21/47 (44%), Positives = 26/47 (55%), Gaps = 4/47 (8%)

Query: 1741 PSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEP 1786
            P C +DVD C   S C   A C N++G Y C+C  P    GKNC+ P
Sbjct: 531  PLCEVDVDLCEP-SPCRNGARCYNLEGDYYCAC--PDDFGGKNCSVP 574



 Score = 37.7 bits (86), Expect = 0.21
 Identities = 30/103 (29%), Positives = 43/103 (41%), Gaps = 15/103 (14%)

Query: 1705 DFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSW-------NGVSPSC-LDVDECAVGSDCS 1756
            D + G T T+  N+   L   +   C D  +W           P C +++DEC   S C+
Sbjct: 779  DGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQ-SSPCA 837

Query: 1757 EHASCLNVDGSYICSCVPPYTGDGKNCAEPI----KCKAPGNP 1795
              A+C++    Y CSC P     G  C E I     C + G P
Sbjct: 838  YGATCVDEINGYRCSCPPGRA--GPRCQEVIGFGRSCWSRGTP 878



 Score = 35.8 bits (81), Expect = 0.78
 Identities = 17/41 (41%), Positives = 22/41 (53%), Gaps = 2/41 (4%)

Query: 1739 VSPSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778
            V  +C LD +EC  G  C    SC N+ G Y C C+P + G
Sbjct: 416  VGATCQLDANECE-GKPCLNAFSCKNLIGGYYCDCIPGWKG 455



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 42/192 (21%), Positives = 66/192 (34%), Gaps = 27/192 (14%)

Query: 1639 PHLRTASEDLKPGSKVNLFCDPGF----------QLVGNPVQYCLNQGQWTQPLPHCERI 1688
            PH R  S+   PG   +  CD GF            +G P   C N G     +   +  
Sbjct: 608  PHGRCVSQ---PGGNFSCICDSGFTGTYCHENIDDCLGQP---CRNGGTC---IDEVDAF 658

Query: 1689 SCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDE 1748
             C  P   E      +         +     Y L+ D   +C  +  W G   +C   + 
Sbjct: 659  RCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVND--FYCACDDGWKG--KTCHSREF 714

Query: 1749 CAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVG 1808
                  CS   +C +   ++ C+C P + G     A+   C  P    NG   G     G
Sbjct: 715  QCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC-LPNPCVNG---GTCVGSG 770

Query: 1809 AEVTFSCQEGYQ 1820
            A  +  C++G++
Sbjct: 771  ASFSCICRDGWE 782


>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
            [Homo sapiens]
          Length = 737

 Score =  224 bits (570), Expect = 2e-57
 Identities = 99/232 (42%), Positives = 126/232 (54%), Gaps = 1/232 (0%)

Query: 1188 EISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCK 1247
            E+       C  +PC N  TC     G+ C CP GY G  CE  +D C+  PC NNG C 
Sbjct: 387  ELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCY 446

Query: 1248 DLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETE 1307
                 F C C  G+TG  C + I+ C+ SPC + G C      Y+C C  G+ GL+CE E
Sbjct: 447  VDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEE 505

Query: 1308 VNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSF 1367
             NEC S PCLN A C D V G+ C C   + GT C    D C +  C NGATC     + 
Sbjct: 506  YNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG 565

Query: 1368 RCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
             C+CA GFTG  C+++INEC SNPC +  +C+D+ N Y+C C  G+ G  CE
Sbjct: 566  TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617



 Score =  200 bits (509), Expect = 2e-50
 Identities = 92/234 (39%), Positives = 128/234 (54%), Gaps = 8/234 (3%)

Query: 1194 FHECFFNPCHNSGTC-----QQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKD 1248
            +  C   PC N+ +C     +Q G  + C+C  GYTG  C++ ID C   PC N   C  
Sbjct: 350  YDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCIS 409

Query: 1249 LVGEFICECPSGYTGQRCEENINECSSSPCLNKGIC-VDGVAGYRCTCVKGFVGLHCETE 1307
             +  F C+CP GY G  CEE ++ C+SSPC N G C VDGV  + C C  GF G  C   
Sbjct: 410  SLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQL 468

Query: 1308 VNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSF 1367
            ++ C  +PC +   C      + C C PG+ G  C +  +ECLS PC N ATC+D  N +
Sbjct: 469  IDFCALSPCAHGT-CRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGY 527

Query: 1368 RCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
             C+C A + G+HCEL  + C +  C N ATC  +  + +C C PGF+G+ C+ +
Sbjct: 528  ECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDID 581



 Score =  178 bits (452), Expect = 7e-44
 Identities = 106/341 (31%), Positives = 152/341 (44%), Gaps = 53/341 (15%)

Query: 1052 CKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSCPENTSTV----KRGAVNISACG 1107
            C  +  + T+S     TCE   +GT+  ++ +     C  N S +    K+   N +   
Sbjct: 325  CTTKPSEATFSC----TCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVC 380

Query: 1108 VPCPEGKFSRSGLMPC--HPCPRDYYQPNAGKAFCLACP--FYGTTPFAGSRSITECSSF 1163
            +P   G+  +S +  C   PC       ++   F   CP  ++G                
Sbjct: 381  LPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFG---------------- 424

Query: 1164 SSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGY 1223
                SA EE V P AS                    +PC N+GTC   G  + C C  G+
Sbjct: 425  ----SACEEKVDPCAS--------------------SPCQNNGTCYVDGVHFTCNCSPGF 460

Query: 1224 TGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGI 1283
            TG  C   ID C+  PC + G C+ +   + C C  GY G  CEE  NEC S+PCLN   
Sbjct: 461  TGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAAT 519

Query: 1284 CVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCG 1343
            C D V GY C C+  + G HCE   + C +  CLN A C+       C C PGF G  C 
Sbjct: 520  CRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECD 579

Query: 1344 KNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNI 1384
             +++EC S PC +G +C D  N + C C  G+ G++CE+++
Sbjct: 580  IDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620



 Score =  150 bits (380), Expect = 2e-35
 Identities = 72/201 (35%), Positives = 96/201 (47%), Gaps = 9/201 (4%)

Query: 1228 CETDIDECSPLPCLNNGVCKDLVGE--FICECPSGYTGQRCEENINECSSSPCLNKGICV 1285
            C       + L C   G C     E  F C C   Y G  CEE  + C   PC N   C+
Sbjct: 307  CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDACQRKPCQNNASCI 365

Query: 1286 DGV-----AGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGT 1340
            D       + + C C+ G+ G  C+++++ C  +PC N A C   + GF C+CP G+ G+
Sbjct: 366  DANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGS 425

Query: 1341 RCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVD 1400
             C + VD C S PC+N  TC      F C C+ GFTG  C   I+ C  +PC +  TC  
Sbjct: 426  ACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRS 484

Query: 1401 ELNSYSCKCQPGFSGKRCETE 1421
               SY C C PG+ G  CE E
Sbjct: 485  VGTSYKCLCDPGYHGLYCEEE 505



 Score = 63.2 bits (152), Expect = 5e-09
 Identities = 38/104 (36%), Positives = 48/104 (46%), Gaps = 15/104 (14%)

Query: 3475 PCQNGGICQ---RPNACSCPEGWMGRLCE---EPICILPCLNGGRCVAPY---QCDCPPG 3525
            PC N   C+       C C   + G  CE   +P   + CLNG  C +      C C PG
Sbjct: 513  PCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPG 572

Query: 3526 WTGSRCHTAV--CQS-PCLNGGKCV-RPN--RCHCLSSWTGHNC 3563
            +TG  C   +  C S PC +GG C+ +PN   CHC   W G NC
Sbjct: 573  FTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 15/86 (17%)

Query: 1349 CLSQPCKNGATCKD------------GANSFRCLCAAGFTGSHCELNINECQSNPCRN-- 1394
            C +QPC+NG  C              G   + C C AG +G++C+L  + C SNPC +  
Sbjct: 48   CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 1395 -QATCVDELNSYSCKCQPGFSGKRCE 1419
              ++     + Y C C  G+ G  CE
Sbjct: 108  CSSSSSSSSDGYLCICNEGYEGPNCE 133



 Score = 60.5 bits (145), Expect = 3e-08
 Identities = 35/101 (34%), Positives = 44/101 (43%), Gaps = 21/101 (20%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEE---PICILPCLNGGRCVAP---YQCDCPPG 3525
            PC+NG  C    +   C CPEG+ G  CEE   P    PC N G C      + C+C PG
Sbjct: 400  PCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPG 459

Query: 3526 WTGSRCHTAV---CQSPCLNGGKCVRPNRCHCLSSWTGHNC 3563
            +TG  C   +     SPC +G          C S  T + C
Sbjct: 460  FTGPTCAQLIDFCALSPCAHG---------TCRSVGTSYKC 491



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 15/85 (17%)

Query: 1273 CSSSPCLNKGICVD------------GVAGYRCTCVKGFVGLHCETEVNECQSNPCLN-- 1318
            C++ PC N G+C              G  GY CTC  G  G +C+   + C SNPC +  
Sbjct: 48   CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 1319 -NAVCEDQVGGFLCKCPPGFLGTRC 1342
             ++       G+LC C  G+ G  C
Sbjct: 108  CSSSSSSSSDGYLCICNEGYEGPNC 132



 Score = 56.6 bits (135), Expect = 4e-07
 Identities = 37/103 (35%), Positives = 48/103 (46%), Gaps = 14/103 (13%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPI--CIL-PCLNGG-RCVAP-YQCDCPPGW 3526
            PCQN G C        C+C  G+ G  C + I  C L PC +G  R V   Y+C C PG+
Sbjct: 438  PCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGY 497

Query: 3527 TGSRC---HTAVCQSPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
             G  C   +     +PCLN   C   V    C CL+ + G +C
Sbjct: 498  HGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHC 540



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 25/86 (29%), Positives = 37/86 (43%), Gaps = 15/86 (17%)

Query: 1311 CQSNPCLNNAVCEDQVG------------GFLCKCPPGFLGTRCGKNVDECLSQPCKNG- 1357
            C + PC N  VC  +              G+ C CP G  G  C    D C S PC +G 
Sbjct: 48   CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 1358 --ATCKDGANSFRCLCAAGFTGSHCE 1381
              ++    ++ + C+C  G+ G +CE
Sbjct: 108  CSSSSSSSSDGYLCICNEGYEGPNCE 133



 Score = 53.1 bits (126), Expect = 5e-06
 Identities = 27/88 (30%), Positives = 35/88 (39%), Gaps = 17/88 (19%)

Query: 1197 CFFNPCHNSGTCQQLGR------------GYVCLCPLGYTGLKCETDIDECSPLPCLNNG 1244
            C   PC N G C                 GY C CP G +G  C+   D C+  PC ++G
Sbjct: 48   CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106

Query: 1245 VCKDLVGE----FICECPSGYTGQRCEE 1268
             C          ++C C  GY G  CE+
Sbjct: 107  NCSSSSSSSSDGYLCICNEGYEGPNCEQ 134



 Score = 52.8 bits (125), Expect = 6e-06
 Identities = 29/87 (33%), Positives = 42/87 (48%), Gaps = 17/87 (19%)

Query: 1235 CSPLPCLNNGVCKDL----------VGE--FICECPSGYTGQRCEENINECSSSPCLNKG 1282
            C+  PC N GVC              GE  + C CP+G +G  C+   + C+S+PC + G
Sbjct: 48   CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106

Query: 1283 ICVDGVA----GYRCTCVKGFVGLHCE 1305
             C    +    GY C C +G+ G +CE
Sbjct: 107  NCSSSSSSSSDGYLCICNEGYEGPNCE 133



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 32/112 (28%), Positives = 46/112 (41%), Gaps = 21/112 (18%)

Query: 3476 CQNGGICQ-RPN----ACSCPEGWMGRLCEEPICIL--PCLNGGRCV--------APYQC 3520
            C   G C  +P+    +C+C E ++G  CEE       PC N   C+        + + C
Sbjct: 319  CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTC 378

Query: 3521 DCPPGWTGSRCHTAV---CQSPCLNGGKCVRP---NRCHCLSSWTGHNCSRK 3566
             C PG+TG  C + +      PC NG  C+       C C   + G  C  K
Sbjct: 379  VCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEK 430



 Score = 46.2 bits (108), Expect = 6e-04
 Identities = 30/112 (26%), Positives = 43/112 (38%), Gaps = 13/112 (11%)

Query: 3433 QYGDMITYSCYSGYMLEGFLRS---VCLENGTWTSPPICRAVC-RFPCQNGGICQRPN-- 3486
            +Y + ++  C +       +     VCL     T   + +  C    C NG  C      
Sbjct: 505  EYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLN 564

Query: 3487 -ACSCPEGWMGRLCEEPICIL---PCLNGGRCVAP---YQCDCPPGWTGSRC 3531
              C C  G+ G  C+  I      PC +GG C+     Y C CP GW G+ C
Sbjct: 565  GTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 28/102 (27%), Positives = 41/102 (40%), Gaps = 26/102 (25%)

Query: 3475 PCQNGGIC-QRPN--------------ACSCPEGWMGRLCE---EPICILPCLNGGRCVA 3516
            PC+NGG+C  RP               +C+CP G  G  C+   +P    PC + G C +
Sbjct: 52   PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHGNCSS 110

Query: 3517 P-------YQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRPNR 3551
                    Y C C  G+ G  C  A+   P     + + P +
Sbjct: 111  SSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQ 152



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 37/140 (26%), Positives = 58/140 (41%), Gaps = 13/140 (9%)

Query: 1645 SEDLKPGSKVNLFCDPGF--QLVGNPVQYCLNQG--QWTQPLPHCERISCGVPPPLENGF 1700
            + + + GS     C PG+  +L  + + YC+          +      +C  P   E  F
Sbjct: 367  ANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCP---EGYF 423

Query: 1701 HSADDFYAGSTVTYQC-NNGYYLLGDSRMFCTDNGSWNGVSPSCLD-VDECAVGSDCSEH 1758
             SA +       +  C NNG   +      C  +  + G  P+C   +D CA+ S C+ H
Sbjct: 424  GSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTG--PTCAQLIDFCAL-SPCA-H 479

Query: 1759 ASCLNVDGSYICSCVPPYTG 1778
             +C +V  SY C C P Y G
Sbjct: 480  GTCRSVGTSYKCLCDPGYHG 499



 Score = 36.6 bits (83), Expect = 0.46
 Identities = 15/29 (51%), Positives = 18/29 (62%), Gaps = 3/29 (10%)

Query: 3475 PCQNGGIC-QRPNA--CSCPEGWMGRLCE 3500
            PC +GG C  +PN   C CP GW+G  CE
Sbjct: 589  PCHHGGSCLDQPNGYNCHCPHGWVGANCE 617



 Score = 36.2 bits (82), Expect = 0.60
 Identities = 25/88 (28%), Positives = 31/88 (35%), Gaps = 24/88 (27%)

Query: 3502 PICILPCLNGGRCV----------AP-----YQCDCPPGWTGSRCHTAV--CQSPCLNGG 3544
            P    PC NGG C           AP     Y C CP G +G+ C      C S   + G
Sbjct: 47   PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHG 106

Query: 3545 KCVRPNR-------CHCLSSWTGHNCSR 3565
             C   +        C C   + G NC +
Sbjct: 107  NCSSSSSSSSDGYLCICNEGYEGPNCEQ 134



 Score = 35.8 bits (81), Expect = 0.78
 Identities = 52/217 (23%), Positives = 62/217 (28%), Gaps = 72/217 (33%)

Query: 288 CDRMGSCKCGTHTGHFECICEKGYYG---------------------------KGLQYEC 320
           C   G C        F C CE+ Y G                            G  + C
Sbjct: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTC 378

Query: 321 TACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPA 380
              P   Y  E     I  CI  P  N  +   S S   C C EGY   G  CE    P 
Sbjct: 379 VCLPG--YTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGY--FGSACEEKVDPC 434

Query: 381 LKPPENGYFIQNTCNNHFNAACGV-------RCHPGFDLVGSSIILCLPNGLWSGSESYC 433
              P         C N  N  C V        C PGF     + ++            +C
Sbjct: 435 ASSP---------CQN--NGTCYVDGVHFTCNCSPGFTGPTCAQLI-----------DFC 472

Query: 434 RVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGY 470
            +  C         H +C +    YK  CL  CD GY
Sbjct: 473 ALSPC--------AHGTCRSVGTSYK--CL--CDPGY 497



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 7/112 (6%)

Query: 335 GGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCP-ALKPPENGYFIQNT 393
           GG+ +  P PD  H +P G      C C  G   SG  C+LV  P A  P  +G    ++
Sbjct: 56  GGVCTSRPEPDPQHPAPAGEPG-YSCTCPAG--ISGANCQLVADPCASNPCHHGNCSSSS 112

Query: 394 CNNHFNAACGVRCHPGFDLVGSSIIL-CLPNGLWSGSESYCRVRTCPHLRQP 444
            ++     C   C+ G++       L  LP   W+ S +  +++  P  ++P
Sbjct: 113 SSSSDGYLC--ICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEP 162


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score =  223 bits (569), Expect = 2e-57
 Identities = 144/441 (32%), Positives = 188/441 (42%), Gaps = 69/441 (15%)

Query: 993  VLRGRMCVNCPLG---TYYNLEHFTCES--CRIGSY-QDEEGQLECKLCPSGMYTEYIHS 1046
            ++ G  CV CP G    +  LE   C S  C  G   +D      C  CP G ++  +  
Sbjct: 440  LVNGYQCV-CPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCH-CPQG-FSGPLCE 496

Query: 1047 RNISDCK-AQCKQGT--YSYSGLETCESCPLGTYQPKFGSRSCL----SCPENTSTVKRG 1099
             ++  C+ + C+ G   Y+  G   C +CP       FG ++C      CP     V   
Sbjct: 497  VDVDLCEPSPCRNGARCYNLEGDYYC-ACP-----DDFGGKNCSVPREPCPGGACRV--- 547

Query: 1100 AVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITE 1159
               I  CG     G    +    C P  R   QP  G  F   C                
Sbjct: 548  ---IDGCGSDAGPGMPGTAASGVCGPHGRCVSQP--GGNFSCICD--------------- 587

Query: 1160 CSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLC 1219
             S F+ T+                   HE       +C   PC N GTC      + C C
Sbjct: 588  -SGFTGTYC------------------HEN----IDDCLGQPCRNGGTCIDEVDAFRCFC 624

Query: 1220 PLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCL 1279
            P G+ G  C+T+ ++C P PC + G C DLV +F C C  G+ G+ C     +C +  C 
Sbjct: 625  PSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCS 684

Query: 1280 NKGICVDGVAGYRCTCVKGFVGLHCETEVNE-CQSNPCLNNAVCEDQVGGFLCKCPPGFL 1338
            N G C D    +RC C  G+ G  C    N  C  NPC+N   C      F C C  G+ 
Sbjct: 685  NGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE 744

Query: 1339 GTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATC 1398
            G  C  N ++C   PC NG  C DG N FRC CA GF G  C +NI+ECQS+PC   ATC
Sbjct: 745  GRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATC 804

Query: 1399 VDELNSYSCKCQPGFSGKRCE 1419
            VDE+N Y C C PG +G RC+
Sbjct: 805  VDEINGYRCSCPPGRAGPRCQ 825



 Score =  211 bits (538), Expect = 8e-54
 Identities = 93/220 (42%), Positives = 125/220 (56%), Gaps = 2/220 (0%)

Query: 1200 NPCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECP 1258
            +PC N GTC       Y C CP GY+G  CE     C+  PC N G C ++   F C CP
Sbjct: 315  HPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCP 374

Query: 1259 SGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLN 1318
            SG++G  C  +I+EC+S+PC   G CVD V G+ C C + +VG  C+ +VN+C+   C +
Sbjct: 375  SGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQH 433

Query: 1319 NAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGS 1378
               C+D V G+ C CP GF G  C    DEC S PC +G  C+D A+ F C C  GF+G 
Sbjct: 434  GGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGP 493

Query: 1379 HCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
             CE++++ C+ +PCRN A C +    Y C C   F GK C
Sbjct: 494  LCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 533



 Score =  197 bits (502), Expect = 1e-49
 Identities = 93/248 (37%), Positives = 122/248 (49%), Gaps = 25/248 (10%)

Query: 1195 HECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
            H C  NPC N G+C ++  G+ C CP G++G  C  DIDEC+  PC   G C D V  F 
Sbjct: 349  HACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFE 408

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
            C CP  + G  C+ ++N+C    C + G C D V GY+C C +GF G HCE E +EC S+
Sbjct: 409  CICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASS 467

Query: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
            PC +  +CED   GF C CP GF G  C  +VD C   PC+NGA C +    + C C   
Sbjct: 468  PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 527

Query: 1375 FTGSHCELNINECQSNPCR-----------------------NQATCVDEL-NSYSCKCQ 1410
            F G +C +    C    CR                           CV +   ++SC C 
Sbjct: 528  FGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICD 587

Query: 1411 PGFSGKRC 1418
             GF+G  C
Sbjct: 588  SGFTGTYC 595



 Score =  197 bits (500), Expect = 2e-49
 Identities = 90/228 (39%), Positives = 129/228 (56%), Gaps = 6/228 (2%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDEC-SPLPCLNNGVCKDLV-GEF 1253
            EC   P    G+C +    + C C   + GL C+ D++ C S  PC N G C +    ++
Sbjct: 275  ECVPYPGCVHGSCVE---PWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQY 331

Query: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQS 1313
             C CP GY+G+ CE+  + C+S+PC N G C +  +G+ C C  G+ G  C  +++EC S
Sbjct: 332  RCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECAS 391

Query: 1314 NPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAA 1373
            NPC     C DQV GF C CP  ++G  C  +V++C  Q C++G TCKD  N ++C+C  
Sbjct: 392  NPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPR 450

Query: 1374 GFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
            GF G HCEL  +EC S+PC +   C D  + + C C  GFSG  CE +
Sbjct: 451  GFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVD 498



 Score =  188 bits (478), Expect = 7e-47
 Identities = 83/253 (32%), Positives = 115/253 (45%), Gaps = 24/253 (9%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            EC  +PCH+ G C+ L  G+ C CP G++G  CE D+D C P PC N   C +L G++ C
Sbjct: 463  ECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYC 522

Query: 1256 ECPSGYTGQRCEENINECSSSPCL------------NKGICVDGVAG------------Y 1291
             CP  + G+ C      C    C               G    GV G            +
Sbjct: 523  ACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNF 582

Query: 1292 RCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLS 1351
             C C  GF G +C   +++C   PC N   C D+V  F C CP G+ G  C  N ++CL 
Sbjct: 583  SCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 642

Query: 1352 QPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQP 1411
             PC +   C D  N F C C  G+ G  C     +C +  C N  TC D  +++ C C P
Sbjct: 643  DPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPP 702

Query: 1412 GFSGKRCETEQST 1424
            G+ G  C   +++
Sbjct: 703  GWKGSTCAVAKNS 715



 Score =  178 bits (451), Expect = 1e-43
 Identities = 81/208 (38%), Positives = 113/208 (54%), Gaps = 10/208 (4%)

Query: 1217 CLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSS 1276
            C C  G+ G  C    DEC P P   +G C   V  + C C + + G  C++++N C S 
Sbjct: 262  CRCSYGWQGRFC----DECVPYPGCVHGSC---VEPWQCNCETNWGGLLCDKDLNYCGSH 314

Query: 1277 -PCLNKGICVDGVAG-YRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCP 1334
             PC N G C++     YRCTC  G+ G +CE   + C SNPC N   C +   GF C CP
Sbjct: 315  HPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCP 374

Query: 1335 PGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRN 1394
             G+ G  C  ++DEC S PC  G TC D  + F C+C   + G+ C+L++N+C+   C++
Sbjct: 375  SGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQH 433

Query: 1395 QATCVDELNSYSCKCQPGFSGKRCETEQ 1422
              TC D +N Y C C  GF G+ CE E+
Sbjct: 434  GGTCKDLVNGYQCVCPRGFGGRHCELER 461



 Score = 82.8 bits (203), Expect = 6e-15
 Identities = 98/374 (26%), Positives = 134/374 (35%), Gaps = 42/374 (11%)

Query: 1028 GQLECKLCPSGMYTEYIHSRNISDCKAQ-CKQGTYSYSGLETCES-CPLGTYQPKFGSR- 1084
            G   C +C SG    Y H  NI DC  Q C+ G      ++     CP G       +  
Sbjct: 580  GNFSC-ICDSGFTGTYCHE-NIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNP 637

Query: 1085 -SCLSCPENTSTVKRGAVNISACGVPCPEGK-----FSRSGLMPCHPCPRDYYQPNAGKA 1138
              CL  P ++       VN   C   C +G       SR      + C       ++G  
Sbjct: 638  NDCLPDPCHSRGRCYDLVNDFYCA--CDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT 695

Query: 1139 FCLACP--FYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFH- 1195
            F  ACP  + G+T      S    S   +        V   AS   I +         H 
Sbjct: 696  FRCACPPGWKGSTCAVAKNS----SCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN 751

Query: 1196 --ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEF 1253
              +C   PC+N G C      + C C  G+ G  C  +IDEC   PC     C D +  +
Sbjct: 752  TNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY 811

Query: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGY-----RCTCVKGFVGLHCETEV 1308
             C CP G  G RC+E I    S  C ++G      + +      C C+ G      +   
Sbjct: 812  RCSCPPGRAGPRCQEVIGFGRS--CWSRGTPFPHGSSWVEDCNSCRCLDG----RRDCSK 865

Query: 1309 NECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRC-GKNVDECLSQPCKNGATC-KDGANS 1366
              C   PCL       Q      +CP   LG RC  K   +CL  PC+    C  +   S
Sbjct: 866  VWCGWKPCL----LAGQPEALSAQCP---LGQRCLEKAPGQCLRPPCEAWGECGAEEPPS 918

Query: 1367 FRCLCAAGFTGSHC 1380
              CL  +G   ++C
Sbjct: 919  TPCLPRSGHLDNNC 932



 Score = 82.4 bits (202), Expect = 7e-15
 Identities = 44/133 (33%), Positives = 62/133 (46%), Gaps = 14/133 (10%)

Query: 3443 YSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQ--NGGICQRPNACSCPEGWMGRLCE 3500
            +  Y  + +    C++   W       AVC+  C   +GG C  P  C C  GW GR C+
Sbjct: 218  FGHYTCDQYGNKACMDG--WMGKECKEAVCKQGCNLLHGG-CTVPGECRCSYGWQGRFCD 274

Query: 3501 EPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAV--CQS--PCLNGGKCVRPN----RC 3552
            E +    C++G  CV P+QC+C   W G  C   +  C S  PC NGG C+       RC
Sbjct: 275  ECVPYPGCVHGS-CVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRC 333

Query: 3553 HCLSSWTGHNCSR 3565
             C   ++G NC +
Sbjct: 334  TCPDGYSGRNCEK 346



 Score = 80.1 bits (196), Expect = 4e-14
 Identities = 56/167 (33%), Positives = 74/167 (44%), Gaps = 36/167 (21%)

Query: 3431 HY---QYGDMITYSCYSGYMLEGFLRSVC-----LENGTWTSPPICRA-----------V 3471
            HY   QYG+    +C  G+M +    +VC     L +G  T P  CR             
Sbjct: 220  HYTCDQYGNK---ACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDEC 276

Query: 3472 CRFPCQNGGICQRPNACSCPEGWMGRLCEEPICIL----PCLNGGRCVAP----YQCDCP 3523
              +P    G C  P  C+C   W G LC++ +       PC NGG C+      Y+C CP
Sbjct: 277  VPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP 336

Query: 3524 PGWTGSRCHTA--VCQS-PCLNGGKCVR-PN--RCHCLSSWTGHNCS 3564
             G++G  C  A   C S PC NGG C   P+   CHC S W+G  C+
Sbjct: 337  DGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCA 383



 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 40/105 (38%), Positives = 49/105 (46%), Gaps = 16/105 (15%)

Query: 3475 PCQNGGICQRPNA----CSCPEGWMGRLCE--EPICIL-PCLNGGRC---VAPYQCDCPP 3524
            PC NGG C         C+CP+G+ GR CE  E  C   PC NGG C    + ++C CP 
Sbjct: 316  PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPS 375

Query: 3525 GWTGSRCHTAV---CQSPCLNGGKCVRP---NRCHCLSSWTGHNC 3563
            GW+G  C   +     +PC  GG CV       C C   W G  C
Sbjct: 376  GWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420



 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 37/106 (34%), Positives = 49/106 (46%), Gaps = 16/106 (15%)

Query: 3475 PCQNGGICQ---RPNACSCPEGWMGRLC---EEPICILPCLNGGRCVAP---YQCDCPPG 3525
            PC + G C        C+C +GW G+ C   E       C NGG C      ++C CPPG
Sbjct: 644  PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPG 703

Query: 3526 WTGSRC----HTAVCQSPCLNGGKCVRPN---RCHCLSSWTGHNCS 3564
            W GS C    +++   +PC+NGG CV       C C   W G  C+
Sbjct: 704  WKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCT 749



 Score = 69.3 bits (168), Expect = 6e-11
 Identities = 56/184 (30%), Positives = 67/184 (36%), Gaps = 37/184 (20%)

Query: 3398 CNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSC---YSGYMLEGFLRS 3454
            C  D+ W   +    +  C            G  Y  GD    +C   + G        S
Sbjct: 660  CACDDGWKGKTCHSREFQCD----AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNS 715

Query: 3455 VCLENGTWTSPPICRAVCRFPCQNGGICQRPNA---CSCPEGWMGRLCEEPI--CI-LPC 3508
             CL N               PC NGG C    A   C C +GW GR C      C  LPC
Sbjct: 716  SCLPN---------------PCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC 760

Query: 3509 LNGGRCVAP---YQCDCPPGWTGSRCHTAV--CQ-SPCLNGGKCV---RPNRCHCLSSWT 3559
             NGG CV     ++C+C PG+ G  C   +  CQ SPC  G  CV      RC C     
Sbjct: 761  YNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRA 820

Query: 3560 GHNC 3563
            G  C
Sbjct: 821  GPRC 824



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 41/111 (36%), Positives = 52/111 (46%), Gaps = 15/111 (13%)

Query: 3472 CRFPCQNGGICQ---RPNACSCPEGWMGRLCE---EPICILPCLNGGRC---VAPYQCDC 3522
            CR  CQ+GG C+       C CP G+ GR CE   +     PC +GG C      + C C
Sbjct: 427  CRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHC 486

Query: 3523 PPGWTGSRCHTAV--CQ-SPCLNGGKCVR---PNRCHCLSSWTGHNCSRKR 3567
            P G++G  C   V  C+ SPC NG +C        C C   + G NCS  R
Sbjct: 487  PQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPR 537



 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 37/103 (35%), Positives = 45/103 (43%), Gaps = 14/103 (13%)

Query: 3475 PCQNGGICQRPN---ACSCPEGWMGRLCEEPI--CILPCLNGGRC---VAPYQCDCPPGW 3526
            PC  GG C        C CPE W+G  C+  +  C   C +GG C   V  YQC CP G+
Sbjct: 393  PCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGF 452

Query: 3527 TGSRC---HTAVCQSPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
             G  C         SPC +GG C        CHC   ++G  C
Sbjct: 453  GGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLC 495



 Score = 58.9 bits (141), Expect = 9e-08
 Identities = 33/89 (37%), Positives = 40/89 (44%), Gaps = 12/89 (13%)

Query: 3487 ACSCPEGWMGRLCEEPI--CI-LPCLNGGRC---VAPYQCDCPPGWTGSRCHT---AVCQ 3537
            +C C  G+ G  C E I  C+  PC NGG C   V  ++C CP GW G  C T       
Sbjct: 583  SCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 642

Query: 3538 SPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
             PC + G+C   V    C C   W G  C
Sbjct: 643  DPCHSRGRCYDLVNDFYCACDDGWKGKTC 671



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 47/167 (28%), Positives = 61/167 (36%), Gaps = 47/167 (28%)

Query: 3442 CYSGYMLEGFLRSVCLENGTWTSPPICRA---VCR-FPCQNGGICQRPNA---CSCPEGW 3494
            C+SG + E              S P+C     +C   PC+NG  C        C+CP+ +
Sbjct: 469  CHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDF 528

Query: 3495 MGRLCEEPICILPCLNG----------------------------GRCVAP----YQCDC 3522
             G+ C  P    PC  G                            GRCV+     + C C
Sbjct: 529  GGKNCSVPR--EPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCIC 586

Query: 3523 PPGWTGSRCHTAV---CQSPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
              G+TG+ CH  +      PC NGG C   V   RC C S W G  C
Sbjct: 587  DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 633



 Score = 56.2 bits (134), Expect = 6e-07
 Identities = 31/81 (38%), Positives = 41/81 (50%), Gaps = 12/81 (14%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPICIL---PCLNGGRCV---APYQCDCPPG 3525
            PC +GG+C+       C CP+G+ G LCE  + +    PC NG RC      Y C CP  
Sbjct: 468  PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 527

Query: 3526 WTGSRCHTAVCQSPCLNGGKC 3546
            + G  C  +V + PC  GG C
Sbjct: 528  FGGKNC--SVPREPC-PGGAC 545



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 41/142 (28%), Positives = 54/142 (38%), Gaps = 17/142 (11%)

Query: 273 DMVHCSYL-CDEG---KDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTY 328
           D+V+  Y  CD+G   K C  R   C   T +    C      Y  G  + C ACP G  
Sbjct: 653 DLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTC------YDSGDTFRC-ACPPGWK 705

Query: 329 KPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGY 388
               +    SSC+P P  N  +  GS +   C+CR+G+     T     C  L     G 
Sbjct: 706 GSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGI 765

Query: 389 FIQNTCNNHFNAACGVRCHPGF 410
            +     N F   C     PGF
Sbjct: 766 CVDGV--NWFRCECA----PGF 781



 Score = 39.3 bits (90), Expect = 0.071
 Identities = 63/281 (22%), Positives = 93/281 (33%), Gaps = 30/281 (10%)

Query: 260 LHEDLPSGSFIQDDMVHCSYLCDEGKDCCDRM---GSCKCGTHTGHFECICEKGYYGKGL 316
           L EDL  G            LC+   D C+        +C    G + C C   + GK  
Sbjct: 474 LCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 533

Query: 317 QYECTACPSGTYK---------PEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYR 367
                 CP G  +           G PG  +S +  P     S PG      C+C  G+ 
Sbjct: 534 SVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNF--SCICDSGF- 590

Query: 368 ASGQTC-ELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGF--DLVGSSIILCLPNG 424
            +G  C E +     +P  NG     TC +  + A    C  G+  +L  ++   CLP+ 
Sbjct: 591 -TGTYCHENIDDCLGQPCRNG----GTCIDEVD-AFRCFCPSGWEGELCDTNPNDCLPDP 644

Query: 425 LWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNS 484
             S    Y  V              +C +RE  ++       + G   +  D   C    
Sbjct: 645 CHSRGRCYDLVNDFYCACDDGWKGKTCHSRE--FQCDAYTCSNGGTCYDSGDTFRCACPP 702

Query: 485 QWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTIC 525
            W G     V ++ S    P    ++   C    A F  IC
Sbjct: 703 GWKG-STCAVAKNSSCLPNP---CVNGGTCVGSGASFSCIC 739



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 21/47 (44%), Positives = 26/47 (55%), Gaps = 4/47 (8%)

Query: 1741 PSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEP 1786
            P C +DVD C   S C   A C N++G Y C+C  P    GKNC+ P
Sbjct: 493  PLCEVDVDLCEP-SPCRNGARCYNLEGDYYCAC--PDDFGGKNCSVP 536



 Score = 37.7 bits (86), Expect = 0.21
 Identities = 30/103 (29%), Positives = 43/103 (41%), Gaps = 15/103 (14%)

Query: 1705 DFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSW-------NGVSPSC-LDVDECAVGSDCS 1756
            D + G T T+  N+   L   +   C D  +W           P C +++DEC   S C+
Sbjct: 741  DGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQ-SSPCA 799

Query: 1757 EHASCLNVDGSYICSCVPPYTGDGKNCAEPI----KCKAPGNP 1795
              A+C++    Y CSC P     G  C E I     C + G P
Sbjct: 800  YGATCVDEINGYRCSCPPGRA--GPRCQEVIGFGRSCWSRGTP 840



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 42/192 (21%), Positives = 66/192 (34%), Gaps = 27/192 (14%)

Query: 1639 PHLRTASEDLKPGSKVNLFCDPGF----------QLVGNPVQYCLNQGQWTQPLPHCERI 1688
            PH R  S+   PG   +  CD GF            +G P   C N G     +   +  
Sbjct: 570  PHGRCVSQ---PGGNFSCICDSGFTGTYCHENIDDCLGQP---CRNGGTC---IDEVDAF 620

Query: 1689 SCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDE 1748
             C  P   E      +         +     Y L+ D   +C  +  W G   +C   + 
Sbjct: 621  RCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVND--FYCACDDGWKG--KTCHSREF 676

Query: 1749 CAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVG 1808
                  CS   +C +   ++ C+C P + G     A+   C  P    NG   G     G
Sbjct: 677  QCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC-LPNPCVNG---GTCVGSG 732

Query: 1809 AEVTFSCQEGYQ 1820
            A  +  C++G++
Sbjct: 733  ASFSCICRDGWE 744


>gi|4502503 complement component 4 binding protein, alpha chain
            precursor [Homo sapiens]
          Length = 597

 Score =  218 bits (554), Expect = 1e-55
 Identities = 147/484 (30%), Positives = 222/484 (45%), Gaps = 50/484 (10%)

Query: 1805 YTVGAEVTFSCQEGYQLMGVTK-ITCLESGEWNHLIPYCKAVSCGKPAIPENGCIE-ELA 1862
            +  G  + ++C  GY     T+ +TC   GEW +   +C    C  P    NG +E +  
Sbjct: 71   FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIKTD 129

Query: 1863 FTFGSKVTYRCNKGYTLAGDKESSCLANS---SWSHSPPVCEPVKCSSPENINNGKYILS 1919
             +FGS++ + C++G+ L G   S C        WSH  P CE VKC  P +I NG++  S
Sbjct: 130  LSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRH--S 187

Query: 1920 G----LTYLSTASYSCDTGYSLQGPSIIECTAS----GIWDRAPPACHLVFCGEPPAIKD 1971
            G      Y  + +YSCD  +SL G + I CT      G+W  +PP C  + C +P     
Sbjct: 188  GEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHG 247

Query: 1972 AVITGNN--FTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDH 2029
             +++G    + +++T+ + C++G+ L G   I C AD KW+ S   C   SC   P + H
Sbjct: 248  EMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPH 307

Query: 2030 ASPETAHR-------LFGDIAFYYCSDGY--SLADNSQLLCNAQGKWVPPEGQDMPRCIA 2080
            AS ET  R       + G +  Y C  GY  +  + + ++C    +W P +G     C A
Sbjct: 308  ASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQG-----CEA 362

Query: 2081 HFCEKPPSVSYSILE-----SVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPS 2135
              C +P   +  I +       +   +  G  +SF C E     +     C   G W+P 
Sbjct: 363  LCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGTWSPR 418

Query: 2136 PMSIQCIPVRCGEPPSIMNG-YASGSNYS-FGAMVAYSCNKGFYIKGEKKSTCEATGQWS 2193
              S   I   C  PP I +G Y   S+YS F   + Y C+KG+ + G+ K +C +   WS
Sbjct: 419  TPSCGDI---CNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWS 474

Query: 2194 SPIPTCHPVSCGEPPKVENGFLEHTTGRIFESE-VRYQCNPGYKSVGSPVFVCQANRHWH 2252
            +P P C  +     P++ NG L     +  E E V  QC+ GY  VG     C  NR W+
Sbjct: 475  APAPQCKALC--RKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWY 532

Query: 2253 SESP 2256
             E P
Sbjct: 533  PEVP 536



 Score =  189 bits (481), Expect = 3e-47
 Identities = 142/508 (27%), Positives = 222/508 (43%), Gaps = 58/508 (11%)

Query: 2083 CEKPPSVSYSILESVS--KAKFAAGSVVSFKCMEGFVLNTSAK-IECMRGGQWNPSPMSI 2139
            C  PP++S++    ++  + +F  G+ + + C+ G+V + S + + C   G+W  +    
Sbjct: 50   CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTF-- 107

Query: 2140 QCIPVRCGEPPSIMNGYAS-GSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQ---WSSP 2195
             CI  RC  P  + NG     ++ SFG+ + +SC++GF++ G   S CE   +   WS P
Sbjct: 108  -CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHP 166

Query: 2196 IPTCHPVSCGEPPKVENGFLEHTTGRIFES---EVRYQCNPGYKSVGSPVFVCQANRH-- 2250
            +P C  V C  PP + NG   H+    F +    V Y C+P +  +G     C       
Sbjct: 167  LPQCEIVKCKPPPDIRNG--RHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETI 224

Query: 2251 --WHSESPLMCVPLDCGKPPPIQNGFMK---GENFEVGSKVQFFCNEGYELVGDSSWTCQ 2305
              W   SP  C  + C KP  + +G M    G  +     + F C +G+ L G S   C 
Sbjct: 225  GVWRP-SPPTCEKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCD 282

Query: 2306 KSGKWNKKSNPKCMPAKC---PEPPLLENQLVLKELTTEVGVV----TFSCKEGH--VLQ 2356
               KWN  S P C P  C   P+ P    +   +    +V VV     + C  G+     
Sbjct: 283  ADSKWNP-SPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTD 341

Query: 2357 GPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGV--------PIPSSALHFGSTVKYSC 2408
             P+ + C  + +W   +  C+  LC P P ++ G         P       +G  + +SC
Sbjct: 342  EPTTVICQKNLRWTP-YQGCE-ALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSC 399

Query: 2409 VGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYL---STALYT 2465
                      + +CQ DGTWS   P C  + C  P +I +G    Q  +Y       +Y 
Sbjct: 400  ----HETSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYK-QSSSYSFFKEEIIYE 453

Query: 2466 CKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHY--GQTVTYS 2523
            C  G+ LVG     C  + HW    P CKA+ C KP E++NG+ S     Y   + VT  
Sbjct: 454  CDKGYILVGQAKLSCSYS-HWSAPAPQCKAL-CRKP-ELVNGRLSVDKDQYVEPENVTIQ 510

Query: 2524 CNRGFRLEGPSALTCLETGDWDVDAPSC 2551
            C+ G+ + GP ++TC     W  + P C
Sbjct: 511  CDSGYGVVGPQSITCSGNRTWYPEVPKC 538



 Score =  178 bits (452), Expect = 7e-44
 Identities = 148/525 (28%), Positives = 216/525 (41%), Gaps = 99/525 (18%)

Query: 2517 GQTVTYSCNRGF-RLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVE-GADYSY 2574
            G T+ Y+C  G+ R      LTC   G+W V    C    C  P  + NG VE   D S+
Sbjct: 74   GTTLKYTCLPGYVRSHSTQTLTCNSDGEW-VYNTFCIYKRCRHPGELRNGQVEIKTDLSF 132

Query: 2575 GAIIIYSCFPGFQVAGHAMQTCEES----GWSSSIPTCMPIDCGLPPHIDFGDCTKLKDD 2630
            G+ I +SC  GF + G     CE      GWS  +P C  + C  PP I  G        
Sbjct: 133  GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGR------- 185

Query: 2631 QGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYE 2690
                                  H G                 + + YG  V+Y+C+P + 
Sbjct: 186  ----------------------HSG---------------EENFYAYGFSVTYSCDPRFS 208

Query: 2691 LLGNPVLICQED----GTWNGSAPSCISIECDLPTAPE----NGF---LRFTETSMGSAV 2739
            LLG+  + C  +    G W  S P+C  I C  P        +GF     + +T     +
Sbjct: 209  LLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDT-----I 263

Query: 2740 QYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGS-------IKGSNYT 2792
             + C+ G +L GS +  C  + KW+ + P CE  SC     + + S        K   Y 
Sbjct: 264  VFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYV 323

Query: 2793 YLSTLYYECDPGYVLNGTERRT--CQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDE-- 2848
              + L Y C PGY     E  T  CQ +  W   +  C  + C  P ++ NG++      
Sbjct: 324  VGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQG-CEALCCPEPKLN-NGEITQHRKS 381

Query: 2849 -------YTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANG- 2900
                   Y +  EI ++C+E        S +C  +G+WS  TP C  + C  PP++A+G 
Sbjct: 382  RPANHCVYFYGDEISFSCHE----TSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGH 436

Query: 2901 VTEGLDYGFMK-EVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHG- 2958
              +   Y F K E+ + C +GYIL G  KL+C S  +W A  P CK + C  PE L +G 
Sbjct: 437  YKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQCKAL-CRKPE-LVNGR 493

Query: 2959 -FPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSC 3002
               +   ++   ++  QC  GY + G  S  C  N +W    P C
Sbjct: 494  LSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538



 Score =  172 bits (435), Expect = 7e-42
 Identities = 152/528 (28%), Positives = 222/528 (42%), Gaps = 62/528 (11%)

Query: 2020 SCDEPPIVDHASP------ETAHRLFGDIAFYYCSDGYSLADNSQLL-CNAQGKWVPPEG 2072
            +C  PP +  A+P      ET  +  G    Y C  GY  + ++Q L CN+ G+WV    
Sbjct: 49   NCGPPPTLSFAAPMDITLTETRFKT-GTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTF 107

Query: 2073 QDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECM---RG 2129
                 CI   C  P  +    +E  +   F  GS + F C EGF L  S    C    RG
Sbjct: 108  -----CIYKRCRHPGELRNGQVEIKTDLSF--GSQIEFSCSEGFFLIGSTTSRCEVQDRG 160

Query: 2130 GQWN-PSPMSIQCIPVRCGEPPSIMNGYASGSN--YSFGAMVAYSCNKGFYIKGEKKSTC 2186
              W+ P P   QC  V+C  PP I NG  SG    Y++G  V YSC+  F + G    +C
Sbjct: 161  VGWSHPLP---QCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISC 217

Query: 2187 ----EATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIF--ESEVRYQCNPGYKSVGS 2240
                E  G W    PTC  ++C +P  V +G +    G I+  +  + ++C  G+   GS
Sbjct: 218  TVENETIGVWRPSPPTCEKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGS 276

Query: 2241 PVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFM-------KGENFEVGSKVQFFCNEG 2293
             V  C A+  W+  SP  C P  C   P I +          K + + VG+ +++ C+ G
Sbjct: 277  SVIHCDADSKWNP-SPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPG 335

Query: 2294 YELVGDSSWT--CQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVG-------- 2343
            Y+   D   T  CQK+ +W       C    CPEP L   ++     +            
Sbjct: 336  YKPTTDEPTTVICQKNLRWTPYQG--CEALCCPEPKLNNGEITQHRKSRPANHCVYFYGD 393

Query: 2344 VVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHF-GS 2402
             ++FSC E           C     W+   P C  + C  PP I+ G    SS+  F   
Sbjct: 394  EISFSCHETSRFSAI----CQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKE 448

Query: 2403 TVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTA 2462
             + Y C  G+ L G +   C     WS+P P+C  + C +PE + NG + V    Y+   
Sbjct: 449  EIIYECDKGYILVGQAKLSCSYSH-WSAPAPQCKAL-CRKPELV-NGRLSVDKDQYVEPE 505

Query: 2463 LYT--CKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGK 2508
              T  C  G+ +VG  +  C  N  W    P C+       +++L GK
Sbjct: 506  NVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGK 553



 Score =  171 bits (432), Expect = 2e-41
 Identities = 139/495 (28%), Positives = 199/495 (40%), Gaps = 58/495 (11%)

Query: 2855 IEYTCNEGFLLE-GARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTE-GLDYGFMKE 2912
            ++YTC  G++     ++  C ++G W   T  C+  RC  P +L NG  E   D  F  +
Sbjct: 77   LKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIKTDLSFGSQ 135

Query: 2913 VTFHCHEGYILHGAPKLTCQSDGN---WDAEIPLCKPVNCGPPEDLAHGFPNGFS--FIH 2967
            + F C EG+ L G+    C+       W   +P C+ V C PP D+ +G  +G    + +
Sbjct: 136  IEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAY 195

Query: 2968 GGHIQYQCFPGYKLHGNSSRRCLSN----GSWSGSSPSCLPCRCSTPVIEYGTVN---GT 3020
            G  + Y C P + L G++S  C       G W  S P+C    C  P + +G +    G 
Sbjct: 196  GFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGP 255

Query: 3021 DFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSS 3080
             ++       +C KGF L G S I C+AD +W+   P CE  SC +LP IP+A      S
Sbjct: 256  IYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHA------S 309

Query: 3081 WKE-------------NVITYSCRSGY--VIQGSSDLICTEKGVWSQPYPVCEPLSCGSP 3125
            W+               V+ Y C  GY       + +IC +   W+ PY  CE L C  P
Sbjct: 310  WETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEP 368

Query: 3126 PSVANAV--------ATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCS 3177
                  +        A    + Y  E+   C E     T   +  CQ DG W P   SC 
Sbjct: 369  KLNNGEITQHRKSRPANHCVYFYGDEISFSCHE-----TSRFSAICQGDGTWSPRTPSCG 423

Query: 3178 PKKCPLPENITH-ILVHGDDFS-VNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDES 3235
               C  P  I H        +S    ++   C +GY   G     C     W  P     
Sbjct: 424  -DICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSY-SHWSAP--APQ 479

Query: 3236 CSPVSCGKPESPEHGFVVG-SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAIC 3294
            C  + C KPE       V   +Y     +  QC+ GY + G +   C  NR W   V  C
Sbjct: 480  CKAL-CRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538

Query: 3295 KETRCETPLEFLNGK 3309
            +    E   + L GK
Sbjct: 539  EWETPEGCEQVLTGK 553



 Score =  169 bits (428), Expect = 5e-41
 Identities = 141/532 (26%), Positives = 216/532 (40%), Gaps = 52/532 (9%)

Query: 2673 SNFLYGTMVSYTCNPGY-ELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRF- 2730
            + F  GT + YTC PGY        L C  DG W  +   CI   C  P    NG +   
Sbjct: 69   TRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIK 127

Query: 2731 TETSMGSAVQYSCKPGHILAGSDLRLC-LENR--KWSGASPRCEAISCKKPNPVMNGSIK 2787
            T+ S GS +++SC  G  L GS    C +++R   WS   P+CE + CK P  + NG   
Sbjct: 128  TDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHS 187

Query: 2788 GSN--YTYLSTLYYECDPGYVLNGTERRTCQDDKN----WDEDEPICIPVDCSSPPVSAN 2841
            G    Y Y  ++ Y CDP + L G    +C  +      W    P C  + C  P VS  
Sbjct: 188  GEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHG 247

Query: 2842 GQVR--GDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLAN 2899
              V   G  Y ++  I + C +GF+L G+    C A+  W+ + P C P  C   P + +
Sbjct: 248  EMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPH 307

Query: 2900 GVTEGLDYGFMKEV-------TFHCHEGY--ILHGAPKLTCQSDGNWDAEIPLCKPVNCG 2950
               E       ++V        + CH GY         + CQ +  W      C+ + C 
Sbjct: 308  ASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRW-TPYQGCEALCCP 366

Query: 2951 PPEDLAHGF---------PNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPS 3001
             P+ L +G           N   + +G  I + C    +     S  C  +G+WS  +PS
Sbjct: 367  EPK-LNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRF----SAICQGDGTWSPRTPS 421

Query: 3002 CLPCRCSTPVIEYGTV-NGTDFDCGKAARI-QCFKGFKLLGLSEITCEADGQWSSGFPHC 3059
            C       P I +G     + +   K   I +C KG+ L+G ++++C +   WS+  P C
Sbjct: 422  CGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQC 480

Query: 3060 EHTSCGSLPMIPNAFISETSSWKE-NVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCE 3118
            +   C    ++      +   + E   +T  C SGY + G   + C+    W    P CE
Sbjct: 481  K-ALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539

Query: 3119 PLSCGSPPSVANAVATG----EAHTYESEVKLRCLEGYTMDTDTDTFTCQKD 3166
                   P     V TG    +      +VK+  LE Y +  + +    Q+D
Sbjct: 540  ----WETPEGCEQVLTGKRLMQCLPNPEDVKM-ALEVYKLSLEIEQLELQRD 586



 Score =  169 bits (427), Expect = 6e-41
 Identities = 129/498 (25%), Positives = 211/498 (42%), Gaps = 49/498 (9%)

Query: 2722 APENGFLRFTETSMGSAVQYSCKPGHILAGSDLRL-CLENRKWSGASPRCEAISCKKPNP 2780
            AP +  L  T    G+ ++Y+C PG++ + S   L C  + +W   +  C    C+ P  
Sbjct: 60   APMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV-YNTFCIYKRCRHPGE 118

Query: 2781 VMNGSIK-GSNYTYLSTLYYECDPGYVLNGTERRTCQ-DDK--NWDEDEPICIPVDCSSP 2836
            + NG ++  ++ ++ S + + C  G+ L G+    C+  D+   W    P C  V C  P
Sbjct: 119  LRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPP 178

Query: 2837 PVSANGQVRGDE--YTFQKEIEYTCNEGFLLEGARSRVCLAN----GSWSGATPDCVPVR 2890
            P   NG+  G+E  Y +   + Y+C+  F L G  S  C       G W  + P C  + 
Sbjct: 179  PDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKIT 238

Query: 2891 CATPPQLANGVTEGLD--YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVN 2948
            C  P      +  G    Y +   + F C +G++L G+  + C +D  W+   P C+P +
Sbjct: 239  CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNS 298

Query: 2949 CGPPEDLAHG----FPNGFS---FIHGGHIQYQCFPGYKLHGNSSRR--CLSNGSWSGSS 2999
            C    D+ H     +P       ++ G  ++Y+C PGYK   +      C  N  W+   
Sbjct: 299  CINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PY 357

Query: 3000 PSCLPCRCSTPVIEYGTV---------NGTDFDCGKAARIQCFKGFKLLGLSEITCEADG 3050
              C    C  P +  G +         N   +  G      C +  +   +    C+ DG
Sbjct: 358  QGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAI----CQGDG 413

Query: 3051 QWSSGFPHCEHTSCGSLPMIPNAFISETSSW---KENVITYSCRSGYVIQGSSDLICTEK 3107
             WS   P C    C   P I +    ++SS+   KE +I Y C  GY++ G + L C+  
Sbjct: 414  TWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEII-YECDKGYILVGQAKLSCSYS 471

Query: 3108 GVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESE-VKLRCLEGYTMDTDTDTFTCQKD 3166
              WS P P C+ L C  P  V   ++  +    E E V ++C  GY +     + TC  +
Sbjct: 472  H-WSAPAPQCKAL-CRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGV-VGPQSITCSGN 528

Query: 3167 GRWFPERISC---SPKKC 3181
              W+PE   C   +P+ C
Sbjct: 529  RTWYPEVPKCEWETPEGC 546



 Score =  168 bits (426), Expect = 8e-41
 Identities = 139/559 (24%), Positives = 239/559 (42%), Gaps = 80/559 (14%)

Query: 1846 SCGKP-----AIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKES-SCLANSSWSHSPPV 1899
            +CG P     A P +  + E  F  G+ + Y C  GY  +   ++ +C ++  W ++   
Sbjct: 49   NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYN-TF 107

Query: 1900 CEPVKCSSPENINNGKY-ILSGLTYLSTASYSCDTGYSLQGPSIIECTAS--GI-WDRAP 1955
            C   +C  P  + NG+  I + L++ S   +SC  G+ L G +   C     G+ W    
Sbjct: 108  CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPL 167

Query: 1956 PACHLVFCGEPPAIKDAVITG--NNFTFRNTVTYTCKEGYTLAGLDTIECLAD----GKW 2009
            P C +V C  PP I++   +G  N + +  +VTY+C   ++L G  +I C  +    G W
Sbjct: 168  PQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVW 227

Query: 2010 SRSDQQCLAVSCDEPPIVDHASPETAH---RLFGDIAFYYCSDGYSLADNSQLLCNAQGK 2066
              S   C  ++C +P  V H    +       + D   + C  G+ L  +S + C+A  K
Sbjct: 228  RPSPPTCEKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSK 286

Query: 2067 WVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAK----FAAGSVVSFKCMEGFVLNTS- 2121
            W P      P C  + C   P + ++  E+  +      +  G+V+ ++C  G+   T  
Sbjct: 287  WNP----SPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDE 342

Query: 2122 -AKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGY---------ASGSNYSFGAMVAYS 2171
               + C +  +W P     Q     C   P + NG          A+   Y +G  +++S
Sbjct: 343  PTTVICQKNLRWTP----YQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFS 398

Query: 2172 CNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENG-FLEHTTGRIFESEVRYQ 2230
            C++         + C+  G WS   P+C  + C  PPK+ +G + + ++   F+ E+ Y+
Sbjct: 399  CHE----TSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEIIYE 453

Query: 2231 CNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGF-MKGENFEVGSKVQFF 2289
            C+ GY  VG     C  + HW + +P  C  L C KP  +     +  + +     V   
Sbjct: 454  CDKGYILVGQAKLSCSYS-HWSAPAP-QCKAL-CRKPELVNGRLSVDKDQYVEPENVTIQ 510

Query: 2290 CNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSC 2349
            C+ GY +VG  S TC  +  W  +  PKC                  E  T  G     C
Sbjct: 511  CDSGYGVVGPQSITCSGNRTWYPEV-PKC------------------EWETPEG-----C 546

Query: 2350 KEGHVLQGPSVLKCLPSQQ 2368
            ++  VL G  +++CLP+ +
Sbjct: 547  EQ--VLTGKRLMQCLPNPE 563



 Score =  166 bits (420), Expect = 4e-40
 Identities = 130/507 (25%), Positives = 204/507 (40%), Gaps = 58/507 (11%)

Query: 2948 NCGPPEDLAHGFPNGFS-----FIHGGHIQYQCFPGY-KLHGNSSRRCLSNGSWSGSSPS 3001
            NCGPP  L+   P   +     F  G  ++Y C PGY + H   +  C S+G W  ++  
Sbjct: 49   NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-F 107

Query: 3002 CLPCRCSTP-VIEYGTVN-GTDFDCGKAARIQCFKGFKLLGLSEITCEADGQ---WSSGF 3056
            C+  RC  P  +  G V   TD   G      C +GF L+G +   CE   +   WS   
Sbjct: 108  CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPL 167

Query: 3057 PHCEHTSCGSLPMIPNAFISETSSWKENV------ITYSCRSGYVIQGSSDLICTEK--- 3107
            P CE   C   P I N       S +EN       +TYSC   + + G + + CT +   
Sbjct: 168  PQCEIVKCKPPPDIRNG----RHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENET 223

Query: 3108 -GVWSQPYPVCEPLSCGSPPSVANAVATG--EAHTYESEVKLRCLEGYTMDTDTDTFTCQ 3164
             GVW    P CE ++C  P      + +G    + Y+  +  +C +G+ +   +    C 
Sbjct: 224  IGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVL-RGSSVIHCD 282

Query: 3165 KDGRWFPERISCSPKKCPLPENITHIL-------VHGDDFSVNRQVSVSCAEGY--TFEG 3215
             D +W P   +C P  C    +I H            D + V   +   C  GY  T + 
Sbjct: 283  ADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDE 342

Query: 3216 VNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSK--------YTFESTIIYQC 3267
                +CQ +  W P    + C  + C +P+          K        Y +   I + C
Sbjct: 343  PTTVICQKNLRWTPY---QGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSC 399

Query: 3268 EPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNG--KADIENRTTGPNVVYSC 3325
                        +CQ +  WS     C +  C  P +  +G  K           ++Y C
Sbjct: 400  HETSRFSA----ICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEIIYEC 454

Query: 3326 NRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCR 3385
            ++GY L G ++  C+ +  WS P P CK   C  P ++     + + ++   +NV+I+C 
Sbjct: 455  DKGYILVGQAKLSCSYSH-WSAPAPQCKAL-CRKPELVNGRLSVDKDQYVEPENVTIQCD 512

Query: 3386 EGFLLQGHGIITCNPDETWTQTSAKCE 3412
             G+ + G   ITC+ + TW     KCE
Sbjct: 513  SGYGVVGPQSITCSGNRTWYPEVPKCE 539



 Score =  158 bits (400), Expect = 8e-38
 Identities = 134/521 (25%), Positives = 213/521 (40%), Gaps = 63/521 (12%)

Query: 1963 CGEPPAIK-----DAVITGNNFTFRNTVTYTCKEGYTLA-GLDTIECLADGKWSRSDQQC 2016
            CG PP +      D  +T   F    T+ YTC  GY  +    T+ C +DG+W   +  C
Sbjct: 50   CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV-YNTFC 108

Query: 2017 LAVSCDEPPIVDHASPETAHRL-FGDIAFYYCSDGYSLADNSQLLCNAQGK---WVPPEG 2072
            +   C  P  + +   E    L FG    + CS+G+ L  ++   C  Q +   W  P  
Sbjct: 109  IYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHP-- 166

Query: 2073 QDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECM----R 2128
              +P+C    C+ PP +      S  +  +A G  V++ C   F L   A I C      
Sbjct: 167  --LPQCEIVKCKPPPDIRNG-RHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENET 223

Query: 2129 GGQWNPSPMSIQCIPVRCGEPP----SIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKS 2184
             G W PSP +  C  + C +P      +++G+  G  Y++   + + C KGF ++G    
Sbjct: 224  IGVWRPSPPT--CEKITCRKPDVSHGEMVSGF--GPIYNYKDTIVFKCQKGFVLRGSSVI 279

Query: 2185 TCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEV-------RYQCNPGYKS 2237
             C+A  +W+   P C P SC   P + +   E T  R  + +V       RY+C+PGYK 
Sbjct: 280  HCDADSKWNPSPPACEPNSCINLPDIPHASWE-TYPRPTKEDVYVVGTVLRYRCHPGYKP 338

Query: 2238 VGS--PVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGEN---------FEVGSKV 2286
                    +CQ N  W   +P       C   P + NG +             +  G ++
Sbjct: 339  TTDEPTTVICQKNLRW---TPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEI 395

Query: 2287 QFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEV--GV 2344
             F C+E        S  CQ  G W+ ++ P C    C  PP + +    +  +       
Sbjct: 396  SFSCHE----TSRFSAICQGDGTWSPRT-PSCGDI-CNFPPKIAHGHYKQSSSYSFFKEE 449

Query: 2345 VTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTV 2404
            + + C +G++L G + L C  S  W+   P CK  LC  P L++  + +          V
Sbjct: 450  IIYECDKGYILVGQAKLSCSYS-HWSAPAPQCK-ALCRKPELVNGRLSVDKDQYVEPENV 507

Query: 2405 KYSCVGGFFLRGNSTTLCQPDGTWSSPLPEC---VPVECPQ 2442
               C  G+ + G  +  C  + TW   +P+C    P  C Q
Sbjct: 508  TIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQ 548



 Score =  155 bits (392), Expect = 7e-37
 Identities = 142/552 (25%), Positives = 227/552 (41%), Gaps = 104/552 (18%)

Query: 2203 SCGEPPKV-----------ENGFLEHTTGRIFESEVRYQCNPGY-KSVGSPVFVCQANRH 2250
            +CG PP +           E  F   TT       ++Y C PGY +S  +    C ++  
Sbjct: 49   NCGPPPTLSFAAPMDITLTETRFKTGTT-------LKYTCLPGYVRSHSTQTLTCNSDGE 101

Query: 2251 WHSESPLMCVPLDCGKPPPIQNGFMKGE-NFEVGSKVQFFCNEGYELVGDSSWTCQKSGK 2309
            W   +   C+   C  P  ++NG ++ + +   GS+++F C+EG+ L+G ++  C+   +
Sbjct: 102  WVYNT--FCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDR 159

Query: 2310 WNKKSNP--KCMPAKCPEPPLLEN-QLVLKELTTEVGV-VTFSCKEGHVLQGPSVLKCLP 2365
                S+P  +C   KC  PP + N +   +E     G  VT+SC     L G + + C  
Sbjct: 160  GVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTV 219

Query: 2366 SQQ----WNDSFPVCKIVLCTPPPLISFGVPIPSSA--LHFGSTVKYSCVGGFFLRGNST 2419
              +    W  S P C+ + C  P  +S G  +       ++  T+ + C  GF LRG+S 
Sbjct: 220  ENETIGVWRPSPPTCEKITCRKPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSV 278

Query: 2420 TLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDV------QGLAYLSTAL-YTCKPGFEL 2472
              C  D  W+   P C P  C    +IP+   +       + +  + T L Y C PG++ 
Sbjct: 279  IHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKP 338

Query: 2473 VGN--TTTLCGENGHWLGGKPTCKAIECLKPK----EILNGKFSYTDLH----YGQTVTY 2522
              +  TT +C +N  W   +  C+A+ C +PK    EI   + S    H    YG  +++
Sbjct: 339  TTDEPTTVICQKNLRWTPYQ-GCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISF 397

Query: 2523 SCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENG-FVEGADYS-YGAIIIY 2580
            SC+   R     +  C   G W    PSC  I C+ P  I +G + + + YS +   IIY
Sbjct: 398  SCHETSRF----SAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEIIY 452

Query: 2581 SCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDM 2640
             C  G+ + G A  +C  S WS+  P C  +            C K +   G    + D 
Sbjct: 453  ECDKGYILVGQAKLSCSYSHWSAPAPQCKAL------------CRKPELVNGRLSVDKDQ 500

Query: 2641 MEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQ 2700
                YV P             EN                 V+  C+ GY ++G   + C 
Sbjct: 501  ----YVEP-------------EN-----------------VTIQCDSGYGVVGPQSITCS 526

Query: 2701 EDGTWNGSAPSC 2712
             + TW    P C
Sbjct: 527  GNRTWYPEVPKC 538



 Score =  148 bits (373), Expect = 1e-34
 Identities = 125/485 (25%), Positives = 204/485 (42%), Gaps = 52/485 (10%)

Query: 1925 STASYSCDTGY-SLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVIT-GNNFTFR 1982
            +T  Y+C  GY        + C + G W      C    C  P  +++  +    + +F 
Sbjct: 75   TTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIKTDLSFG 133

Query: 1983 NTVTYTCKEGYTLAGLDTIECLADGK---WSRSDQQCLAVSCDEPPIVDHA--SPETAHR 2037
            + + ++C EG+ L G  T  C    +   WS    QC  V C  PP + +   S E    
Sbjct: 134  SQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFY 193

Query: 2038 LFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESV 2097
             +G    Y C   +SL  ++ + C  + + +       P C    C KP  VS+  + S 
Sbjct: 194  AYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKP-DVSHGEMVSG 252

Query: 2098 SKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGY- 2156
                +     + FKC +GFVL  S+ I C    +WNPSP +  C P  C   P I +   
Sbjct: 253  FGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPA--CEPNSCINLPDIPHASW 310

Query: 2157 ------ASGSNYSFGAMVAYSCNKGFYIKGEKKST--CEATGQWSSPIPTCHPVSCGEPP 2208
                       Y  G ++ Y C+ G+    ++ +T  C+   +W+ P   C  + C EP 
Sbjct: 311  ETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEALCCPEP- 368

Query: 2209 KVENGFL-EHTTGR-------IFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCV 2260
            K+ NG + +H   R        +  E+ + C+   +       +CQ +  W   +P  C 
Sbjct: 369  KLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSA----ICQGDGTWSPRTP-SCG 423

Query: 2261 PLDCGKPPPIQNGFMKGENFEVGSKVQFF-------CNEGYELVGDSSWTCQKSGKWNKK 2313
             + C  PP I +G     +++  S   FF       C++GY LVG +  +C  S  W+  
Sbjct: 424  DI-CNFPPKIAHG-----HYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYS-HWSAP 476

Query: 2314 SNPKCMPAKCPEPPLLENQL-VLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDS 2372
            + P+C  A C +P L+  +L V K+   E   VT  C  G+ + GP  + C  ++ W   
Sbjct: 477  A-PQCK-ALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPE 534

Query: 2373 FPVCK 2377
             P C+
Sbjct: 535  VPKCE 539



 Score =  147 bits (370), Expect = 2e-34
 Identities = 122/463 (26%), Positives = 186/463 (40%), Gaps = 84/463 (18%)

Query: 1647 DLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQ---WTQPLPHCERISCGVPPPLENGFHSA 1703
            DL  GS++   C  GF L+G+    C  Q +   W+ PLP CE + C  PP + NG HS 
Sbjct: 129  DLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSG 188

Query: 1704 DD-FYA-GSTVTYQCNNGYYLLGDSRMFCTDN----GSWNGVSPSCLDVDECAVGSDCSE 1757
            ++ FYA G +VTY C+  + LLG + + CT      G W    P+C              
Sbjct: 189  EENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC-------------- 234

Query: 1758 HASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAP--GNPENGHSSGEIYTVGAEVTFSC 1815
                                       E I C+ P   + E     G IY     + F C
Sbjct: 235  ---------------------------EKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKC 267

Query: 1816 QEGYQLMGVTKITCLESGEWNHLIPYCKAVSC-GKPAIPENGC------IEELAFTFGSK 1868
            Q+G+ L G + I C    +WN   P C+  SC   P IP           +E  +  G+ 
Sbjct: 268  QKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTV 327

Query: 1869 VTYRCNKGYTLAGDKESSCLANSSWSHSP-PVCEPVKCSSPENINNGKYILSGLT----- 1922
            + YRC+ GY    D+ ++ +   +   +P   CE + C  P+ +NNG+      +     
Sbjct: 328  LRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGCEALCCPEPK-LNNGEITQHRKSRPANH 386

Query: 1923 ----YLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVI--TG 1976
                Y    S+SC   +     S I C   G W    P+C  + C  PP I       + 
Sbjct: 387  CVYFYGDEISFSC---HETSRFSAI-CQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSS 441

Query: 1977 NNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVD-HASPETA 2035
            +   F+  + Y C +GY L G   + C +   WS    QC A+ C +P +V+   S +  
Sbjct: 442  SYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQCKAL-CRKPELVNGRLSVDKD 499

Query: 2036 HRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRC 2078
              +  +     C  GY +     + C+    W P    ++P+C
Sbjct: 500  QYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYP----EVPKC 538



 Score =  132 bits (331), Expect = 8e-30
 Identities = 102/391 (26%), Positives = 154/391 (39%), Gaps = 46/391 (11%)

Query: 3121 SCGSPPSVANAVA-----TGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERIS 3175
            +CG PP+++ A       T       + +K  CL GY     T T TC  DG W      
Sbjct: 49   NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTF- 107

Query: 3176 CSPKKCPLPENITHILVH-GDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGT---WEPPF 3231
            C  K+C  P  + +  V    D S   Q+  SC+EG+   G   S C++      W  P 
Sbjct: 108  CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPL 167

Query: 3232 SDESCSPVSCGKPESPEHGFVVGSK--YTFESTIIYQCEPGYELEGNRERVCQENRQ--- 3286
                C  V C  P    +G   G +  Y +  ++ Y C+P + L G+    C    +   
Sbjct: 168  PQ--CEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIG 225

Query: 3287 -WSGGVAICKETRCETPL----EFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTE 3341
             W      C++  C  P     E ++G   I N      +V+ C +G+ L G S  HC  
Sbjct: 226  VWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKD--TIVFKCQKGFVLRGSSVIHCDA 283

Query: 3342 NGTWSHPVPLCKPNPC----PVPFVIPENALLSEKE--FYVDQNVSIKCREGF--LLQGH 3393
            +  W+   P C+PN C     +P    E      KE  + V   +  +C  G+       
Sbjct: 284  DSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEP 343

Query: 3394 GIITCNPDETWTQTSAKCEKISCGPP--------AHVENAIARGVHYQYGDMITYSCYSG 3445
              + C  +  WT     CE + C  P         H ++  A    Y YGD I++SC+  
Sbjct: 344  TTVICQKNLRWTPYQG-CEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHE- 401

Query: 3446 YMLEGFLRSVCLENGTWT-SPPICRAVCRFP 3475
                    ++C  +GTW+   P C  +C FP
Sbjct: 402  ---TSRFSAICQGDGTWSPRTPSCGDICNFP 429



 Score =  127 bits (320), Expect = 2e-28
 Identities = 115/486 (23%), Positives = 197/486 (40%), Gaps = 58/486 (11%)

Query: 3016 TVNGTDFDCGKAARIQCFKGF-KLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAF 3074
            T+  T F  G   +  C  G+ +      +TC +DG+W      C +  C     + N  
Sbjct: 65   TLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYN-TFCIYKRCRHPGELRNGQ 123

Query: 3075 IS-ETSSWKENVITYSCRSGYVIQGSSDLICT--EKGV-WSQPYPVCEPLSCGSPPSVAN 3130
            +  +T     + I +SC  G+ + GS+   C   ++GV WS P P CE + C  PP + N
Sbjct: 124  VEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRN 183

Query: 3131 AVATGEAH--------TYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCP 3182
               +GE +        TY  + +   L   ++    +  T    G W P   +C    C 
Sbjct: 184  GRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETI---GVWRPSPPTCEKITCR 240

Query: 3183 LPENITH---ILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPV 3239
             P+ ++H   +   G  ++    +   C +G+   G ++  C  D  W P  S  +C P 
Sbjct: 241  KPD-VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNP--SPPACEPN 297

Query: 3240 SC-GKPESPEHGFVVGSKYTFESTII------YQCEPGYELEGNRER--VCQENRQWS-- 3288
            SC   P+ P   +    + T E   +      Y+C PGY+   +     +CQ+N +W+  
Sbjct: 298  SCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPY 357

Query: 3289 -GGVAICKETRCETPLEFLNGKADIENRTT---------GPNVVYSCNRGYSLEGPSEAH 3338
             G  A+C    C  P +  NG+     ++          G  + +SC+          A 
Sbjct: 358  QGCEALC----CPEP-KLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFS----AI 408

Query: 3339 CTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEF-YVDQNVSIKCREGFLLQGHGIIT 3397
            C  +GTWS   P C  + C  P  I          + +  + +  +C +G++L G   ++
Sbjct: 409  CQGDGTWSPRTPSCG-DICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLS 467

Query: 3398 CNPDETWTQTSAKCEKISCGPPAHVENAIARGV-HYQYGDMITYSCYSGYMLEGFLRSVC 3456
            C+    W+  + +C+ + C  P  V   ++     Y   + +T  C SGY + G     C
Sbjct: 468  CSYSH-WSAPAPQCKAL-CRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC 525

Query: 3457 LENGTW 3462
              N TW
Sbjct: 526  SGNRTW 531



 Score =  117 bits (292), Expect = 3e-25
 Identities = 112/451 (24%), Positives = 181/451 (40%), Gaps = 50/451 (11%)

Query: 3063 SCGSLPMIPNAF-----ISETSSWKENVITYSCRSGYVIQGSSD-LICTEKGVWSQPYPV 3116
            +CG  P +  A      ++ET       + Y+C  GYV   S+  L C   G W      
Sbjct: 49   NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYN-TF 107

Query: 3117 CEPLSCGSPPSVANA-VATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGR---WFPE 3172
            C    C  P  + N  V      ++ S+++  C EG+ +   T T  C+   R   W   
Sbjct: 108  CIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGST-TSRCEVQDRGVGWSHP 166

Query: 3173 RISCSPKKCPLPENITHILVHGDD--FSVNRQVSVSCAEGYTFEGVNISVCQLD----GT 3226
               C   KC  P +I +    G++  ++    V+ SC   ++  G     C ++    G 
Sbjct: 167  LPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGV 226

Query: 3227 WEPPFSDESCSPVSCGKPESPEHGFVV---GSKYTFESTIIYQCEPGYELEGNRERVCQE 3283
            W P  S  +C  ++C KP+   HG +V   G  Y ++ TI+++C+ G+ L G+    C  
Sbjct: 227  WRP--SPPTCEKITCRKPDV-SHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDA 283

Query: 3284 NRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVV-------YSCNRGY--SLEGP 3334
            + +W+     C+   C    +  +   +   R T  +V        Y C+ GY  + + P
Sbjct: 284  DSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEP 343

Query: 3335 SEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKE--------FYVDQNVSIKCRE 3386
            +   C +N  W+ P   C+   CP P +         K         FY D+ +S  C E
Sbjct: 344  TTVICQKNLRWT-PYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDE-ISFSCHE 401

Query: 3387 GFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQY-GDMITYSCYSG 3445
                       C  D TW+  +  C  I   PP        +   Y +  + I Y C  G
Sbjct: 402  TSRFSA----ICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKG 457

Query: 3446 YMLEGFLRSVCLENGTWTSP-PICRAVCRFP 3475
            Y+L G  +  C     W++P P C+A+CR P
Sbjct: 458  YILVGQAKLSC-SYSHWSAPAPQCKALCRKP 487



 Score = 81.6 bits (200), Expect = 1e-14
 Identities = 76/298 (25%), Positives = 118/298 (39%), Gaps = 39/298 (13%)

Query: 1658 CDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSA-------DDFYAGS 1710
            C  GF L G+ V +C    +W    P CE  SC   P + +            D +  G+
Sbjct: 267  CQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGT 326

Query: 1711 TVTYQCNNGYYLLGD--SRMFCTDNGSWN---GVSPSCLDVDECAVGSDCSEHAS----- 1760
             + Y+C+ GY    D  + + C  N  W    G    C    +   G       S     
Sbjct: 327  VLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANH 386

Query: 1761 CLNVDG---SYICSCVPPYT----GDGK------NCAEPIKCKAPGNPENGH--SSGEIY 1805
            C+   G   S+ C     ++    GDG       +C +   C  P    +GH   S    
Sbjct: 387  CVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGDI--CNFPPKIAHGHYKQSSSYS 444

Query: 1806 TVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENG--CIEELAF 1863
                E+ + C +GY L+G  K++C  S  W+   P CKA+ C KP +  NG   +++  +
Sbjct: 445  FFKEEIIYECDKGYILVGQAKLSCSYS-HWSAPAPQCKAL-CRKPELV-NGRLSVDKDQY 501

Query: 1864 TFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGL 1921
                 VT +C+ GY + G +  +C  N +W    P CE       E +  GK ++  L
Sbjct: 502  VEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKRLMQCL 559



 Score = 55.8 bits (133), Expect = 7e-07
 Identities = 48/176 (27%), Positives = 74/176 (42%), Gaps = 24/176 (13%)

Query: 373 CELVHCPALKPPENGYFIQNTCNNHFNA---ACGVRCHPGFDLVGSSIILCLPN----GL 425
           CE+V C   KPP +    +++   +F A   +    C P F L+G + I C       G+
Sbjct: 170 CEIVKC---KPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGV 226

Query: 426 WSGSESYCRVRTCPHLRQP--KHGHISCSTREML-YKTTCLVACDEGYRLEGSDKLTCQG 482
           W  S   C   TC   R+P   HG +      +  YK T +  C +G+ L GS  + C  
Sbjct: 227 WRPSPPTCEKITC---RKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDA 283

Query: 483 NSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAK-----FGTICYVSCRQGF 533
           +S+W+   P C    C    +P D+  +      +P K      GT+    C  G+
Sbjct: 284 DSKWNPSPPACEPNSC--INLP-DIPHASWETYPRPTKEDVYVVGTVLRYRCHPGY 336



 Score = 50.1 bits (118), Expect = 4e-05
 Identities = 30/115 (26%), Positives = 52/115 (45%), Gaps = 9/115 (7%)

Query: 383 PPE--NGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPH 440
           PP+  +G++ Q++  + F       C  G+ LVG + + C  +  WS     C+      
Sbjct: 429 PPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSH-WSAPAPQCKALC--- 484

Query: 441 LRQPK--HGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRC 493
            R+P+  +G +S    + +      + CD GY + G   +TC GN  W    P+C
Sbjct: 485 -RKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538



 Score = 44.7 bits (104), Expect = 0.002
 Identities = 53/224 (23%), Positives = 83/224 (37%), Gaps = 27/224 (12%)

Query: 398 FNAACGVRCHPGFDLVGSSIILC--LPNGL-WSGSESYCRVRTCPHLRQPKHGHISCSTR 454
           F +     C  GF L+GS+   C     G+ WS     C +  C      ++G  S    
Sbjct: 132 FGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEEN 191

Query: 455 EMLYKTTCLVACDEGYRLEGSDKLTCQGNSQ----WDGPEPRCVERHCSTFQMPKDVIIS 510
              Y  +   +CD  + L G   ++C   ++    W    P C +  C    +    ++S
Sbjct: 192 FYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVS 251

Query: 511 PHNCGKQPA-KFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINC 569
               G  P   +       C++GF+L G   ++ C    KWN    A  C+      IN 
Sbjct: 252 ----GFGPIYNYKDTIVFKCQKGFVLRG-SSVIHCDADSKWNPSPPA--CEPNSC--INL 302

Query: 570 PKDIEAKTLEQQDSANVTWQIPTAKD--NSGEKVSVHVHPAFTP 611
           P DI   + E       T+  PT +D    G  +    HP + P
Sbjct: 303 P-DIPHASWE-------TYPRPTKEDVYVVGTVLRYRCHPGYKP 338



 Score = 33.1 bits (74), Expect = 5.1
 Identities = 48/223 (21%), Positives = 79/223 (35%), Gaps = 40/223 (17%)

Query: 338 SSCIPCPDENHTSP-PGSTSPEDCVCREGY-RASGQTCELVHCPALKPPENGYFIQNTCN 395
           SS I C  ++  +P P +  P  C+       AS +T         +P +   ++  T  
Sbjct: 276 SSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYP-------RPTKEDVYVVGTVL 328

Query: 396 NHFNAACGVRCHPGFDLVGS--SIILCLPNGLWSGSESYCRVRTCPHLRQPK--HGHISC 451
            +       RCHPG+       + ++C  N  W+  +  C    CP   +PK  +G I+ 
Sbjct: 329 RY-------RCHPGYKPTTDEPTTVICQKNLRWTPYQG-CEALCCP---EPKLNNGEITQ 377

Query: 452 STREM-------LYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMP 504
             +          Y      +C E  R        CQG+  W    P C +        P
Sbjct: 378 HRKSRPANHCVYFYGDEISFSCHETSRFSA----ICQGDGTWSPRTPSCGD----ICNFP 429

Query: 505 KDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTS 547
             +    +      + F       C +G+IL G +  L C+ S
Sbjct: 430 PKIAHGHYKQSSSYSFFKEEIIYECDKGYILVG-QAKLSCSYS 471


>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
          Length = 685

 Score =  217 bits (553), Expect = 1e-55
 Identities = 99/227 (43%), Positives = 127/227 (55%), Gaps = 7/227 (3%)

Query: 1200 NPCHNSGTCQQLG-RGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECP 1258
            +PC N  TC   G R Y C C  GYTG+ CE ++ EC   PC N G CKD    + C CP
Sbjct: 292  SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCP 351

Query: 1259 SGYTGQRCEENINECSSSPCLNKGICVDGVAG--YRCTCVKGFVGLHCETEVNECQSNPC 1316
             GY G  CE +   C+ SPC N G C +   G  Y C C   F G +CE +V+ C SNPC
Sbjct: 352  PGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPC 411

Query: 1317 LNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFT 1376
             N   C ++    +C+C PGF GT C  +V +C   PC +G TC D  N   C C AGF+
Sbjct: 412  ANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFS 471

Query: 1377 GSHCEL--NINECQSNPCRNQATCVDEL--NSYSCKCQPGFSGKRCE 1419
            G  CE+  +I+ C S+PC N+ATC  +L  +++ C C  GF G RCE
Sbjct: 472  GRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518



 Score =  206 bits (524), Expect = 3e-52
 Identities = 97/234 (41%), Positives = 126/234 (53%), Gaps = 9/234 (3%)

Query: 1195 HECF-FNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSP-LPCLNNGVCKDL-VG 1251
            +EC   N C + GTC      + C C  G+ GL C+ D++ C+   PC N   C +    
Sbjct: 251  NECIPHNGCRH-GTCST---PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQR 306

Query: 1252 EFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNEC 1311
             + C C  GYTG  CE  ++EC S+PC N G C D   GY C C  G+ GLHCE     C
Sbjct: 307  SYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSC 366

Query: 1312 QSNPCLNNAVCEDQVGG--FLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRC 1369
              +PC N   C ++  G  + C+CPP F G+ C K VD C S PC NG  C +   S  C
Sbjct: 367  ADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMC 426

Query: 1370 LCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQS 1423
             C  GFTG++CEL++++C  NPC +  TC D  N   C C  GFSG+RCE   S
Sbjct: 427  RCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTS 480



 Score =  186 bits (473), Expect = 3e-46
 Identities = 84/202 (41%), Positives = 108/202 (53%), Gaps = 6/202 (2%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLV--GEF 1253
            EC  NPC N G+C+    GY CLCP GY GL CE     C+  PC N G C++      +
Sbjct: 327  ECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANY 386

Query: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQS 1313
             CECP  +TG  CE+ ++ C+S+PC N G C++      C C  GF G +CE  V++C  
Sbjct: 387  ACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCAR 446

Query: 1314 NPCLNNAVCEDQVGGFLCKCPPGFLGTRCG--KNVDECLSQPCKNGATCKD--GANSFRC 1369
            NPC +   C D   G +C CP GF G RC    ++D C S PC N ATC      ++F C
Sbjct: 447  NPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVC 506

Query: 1370 LCAAGFTGSHCELNINECQSNP 1391
             C  GF GS CE  +    S P
Sbjct: 507  NCPYGFVGSRCEFPVGLPPSFP 528



 Score = 78.2 bits (191), Expect = 1e-13
 Identities = 45/106 (42%), Positives = 54/106 (50%), Gaps = 17/106 (16%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPICIL---PCLNGGRCV-----APYQCDCP 3523
            PC+NGG C+       C CP G+ G  CE         PC NGG C      A Y C+CP
Sbjct: 332  PCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECP 391

Query: 3524 PGWTGSRCHTAV--CQS-PCLNGGKCVR--PNR-CHCLSSWTGHNC 3563
            P +TGS C   V  C S PC NGG+C+   P+R C C   +TG  C
Sbjct: 392  PNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYC 437



 Score = 76.3 bits (186), Expect = 5e-13
 Identities = 48/146 (32%), Positives = 61/146 (41%), Gaps = 20/146 (13%)

Query: 3434 YGDMITYSC------YSGYMLEGFLRSVCLEN--GTWTSPPICRAVCRFPCQNGGICQRP 3485
            YGD  +  C      +  Y+ +      CL    G +   PIC + C    +  G C +P
Sbjct: 180  YGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCH---EQNGYCSKP 236

Query: 3486 NACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRC----HTAVCQSPCL 3541
              C C  GW GRLC E I    C + G C  P+QC C  GW G  C    +     SPC 
Sbjct: 237  AECLCRPGWQGRLCNECIPHNGCRH-GTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCK 295

Query: 3542 NGGKC----VRPNRCHCLSSWTGHNC 3563
            NG  C     R   C C   +TG +C
Sbjct: 296  NGATCSNSGQRSYTCTCRPGYTGVDC 321



 Score = 76.3 bits (186), Expect = 5e-13
 Identities = 44/110 (40%), Positives = 53/110 (48%), Gaps = 18/110 (16%)

Query: 3475 PCQNGGIC----QRPNACSCPEGWMGRLCEEPICIL---PCLNGGRCVAP---YQCDCPP 3524
            PC+NG  C    QR   C+C  G+ G  CE  +      PC NGG C      Y C CPP
Sbjct: 293  PCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPP 352

Query: 3525 GWTGSRCH--TAVC-QSPCLNGGKCVRPNR-----CHCLSSWTGHNCSRK 3566
            G+ G  C   T  C  SPC NGG C   N+     C C  ++TG NC +K
Sbjct: 353  GYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKK 402



 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 34/101 (33%), Positives = 48/101 (47%), Gaps = 4/101 (3%)

Query: 3468 CRAVCRFPCQNGG--ICQRPNACSCPEGWMGRLCEEPICILPCLN-GGRCVAPYQCDCPP 3524
            C  +C+    + G  +CQ     SC  GW G  C++PIC+  C    G C  P +C C P
Sbjct: 184  CSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRP 243

Query: 3525 GWTGSRCHTAVCQSPCLNGGKCVRPNRCHCLSSWTGHNCSR 3565
            GW G  C+  +  + C +G  C  P +C C   W G  C +
Sbjct: 244  GWQGRLCNECIPHNGCRHG-TCSTPWQCTCDEGWGGLFCDQ 283



 Score = 53.9 bits (128), Expect = 3e-06
 Identities = 34/108 (31%), Positives = 41/108 (37%), Gaps = 19/108 (17%)

Query: 3475 PCQNGGICQR---PNACSCPEGWMGRLCEEPICIL---PCLNGGRC---VAPYQCDCPPG 3525
            PC NGG C        C C  G+ G  CE  +      PC +GG C        C CP G
Sbjct: 410  PCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAG 469

Query: 3526 WTGSRCHT-----AVCQSPCLNGGKCVRPNR-----CHCLSSWTGHNC 3563
            ++G RC       A   SPC N   C          C+C   + G  C
Sbjct: 470  FSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 29/80 (36%), Positives = 36/80 (45%), Gaps = 13/80 (16%)

Query: 3473 RFPCQNGGIC---QRPNACSCPEGWMGRLCEEPICI-----LPCLNGGRCVAP-----YQ 3519
            R PC +GG C   +    C+CP G+ GR CE    I      PC N   C        + 
Sbjct: 446  RNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFV 505

Query: 3520 CDCPPGWTGSRCHTAVCQSP 3539
            C+CP G+ GSRC   V   P
Sbjct: 506  CNCPYGFVGSRCEFPVGLPP 525



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 36/152 (23%), Positives = 54/152 (35%), Gaps = 35/152 (23%)

Query: 276 HCSYLCDEGKDCCDRMGSCKCGTHTGHFEC------ICEKGYYGKGLQYECTACPSGTYK 329
           +CS LC +  D            H GH+ C       C  G+ G+  Q     C SG ++
Sbjct: 183 NCSRLCKKRND------------HFGHYVCQPDGNLSCLPGWTGEYCQQPI--CLSGCHE 228

Query: 330 PEGSPGGISSCI-----------PCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHC 378
             G     + C+            C   N       ++P  C C EG+       +L +C
Sbjct: 229 QNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYC 288

Query: 379 PALKPPENGYFIQNTCNNHFNAACGVRCHPGF 410
               P +NG     TC+N    +    C PG+
Sbjct: 289 THHSPCKNG----ATCSNSGQRSYTCTCRPGY 316



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 19/50 (38%), Positives = 25/50 (50%), Gaps = 2/50 (4%)

Query: 1730 CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNV-DGSYICSCVPPYTG 1778
            CT +  W G+     D++ C   S C   A+C N    SY C+C P YTG
Sbjct: 270  CTCDEGWGGLFCD-QDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTG 318



 Score = 34.7 bits (78), Expect = 1.7
 Identities = 40/161 (24%), Positives = 53/161 (32%), Gaps = 40/161 (24%)

Query: 281 CDEGKDCCDRMGSCKCGTHTGH-----FECICEKGYYGKGLQYECTACPSGTYKPEGSPG 335
           CD+  + C     CK G    +     + C C  GY G   + E + C S   +  G   
Sbjct: 281 CDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGG--- 337

Query: 336 GISSCIPCPDENH-TSPPG-----------STSPEDCV----CREGYRASGQTCELVHCP 379
              SC    D  H   PPG           S +   C     CRE  + +   CE   CP
Sbjct: 338 ---SCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACE---CP 391

Query: 380 ALKPPENGYFIQNTCNNHFNAACG----------VRCHPGF 410
                 N     + C ++  A  G           RC PGF
Sbjct: 392 PNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGF 432


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  211 bits (536), Expect = 1e-53
 Identities = 100/242 (41%), Positives = 124/242 (51%), Gaps = 12/242 (4%)

Query: 1197 CFFNPCHNSGTCQQLG-RGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGE--- 1252
            C  +PC N GTC       Y C CP GY G  CE  +D CS  PC N G C    GE   
Sbjct: 929  CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988

Query: 1253 FICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQ 1312
            F C CP+G+ G  C  N ++C    C N G+CVDGV  Y C C   + G  CE  V+ C 
Sbjct: 989  FTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCS 1048

Query: 1313 S--NPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCL 1370
               NPC + A C     G  C+C PG+ G  C +N D+C    C+NGA C D  NS+ CL
Sbjct: 1049 PDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCL 1108

Query: 1371 CAAGFTGSHCEL------NINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQST 1424
            CA G++G  CE+        + C+   C+N A CVD+ N   C+C PGF G  CE   S 
Sbjct: 1109 CAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSV 1168

Query: 1425 GF 1426
             F
Sbjct: 1169 NF 1170



 Score =  166 bits (419), Expect = 5e-40
 Identities = 79/200 (39%), Positives = 110/200 (55%), Gaps = 6/200 (3%)

Query: 1226 LKCETDIDECSPLPCLNNGVC-KDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGIC 1284
            L  +   D C   PC N G C  D +  + C CPSGY G+ CE +++ CSS PC N G C
Sbjct: 920  LAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTC 979

Query: 1285 --VDGV-AGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTR 1341
               +G  A + C+C  GF G  C    ++C  + C N  VC D VG + C+CP  + G  
Sbjct: 980  HAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKA 1039

Query: 1342 CGKNVDECLS--QPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCV 1399
            C + VD C     PC++ A C    +  RC C  G+ G +C  N ++C+ + C+N A C+
Sbjct: 1040 CEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCM 1099

Query: 1400 DELNSYSCKCQPGFSGKRCE 1419
            DE+NSYSC C  G+SG+ CE
Sbjct: 1100 DEVNSYSCLCAEGYSGQLCE 1119



 Score =  114 bits (286), Expect = 1e-24
 Identities = 58/157 (36%), Positives = 71/157 (45%), Gaps = 8/157 (5%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSP--LPCLNNGVCKDLVGEF 1253
            +C  + C N G C      Y C CPL Y G  CE  +D CSP   PC +   C       
Sbjct: 1008 DCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGP 1067

Query: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCE------TE 1307
             CEC  GY G  C EN ++C    C N   C+D V  Y C C +G+ G  CE        
Sbjct: 1068 RCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAP 1127

Query: 1308 VNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGK 1344
             + C+   C N A C DQ    +C+C PGF G  C K
Sbjct: 1128 KSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEK 1164



 Score = 73.2 bits (178), Expect = 4e-12
 Identities = 36/95 (37%), Positives = 49/95 (51%), Gaps = 9/95 (9%)

Query: 1329 FLCKCPPGF-LGTRCGKNVDECLSQPCKNGATC-KDGANSFRCLCAAGFTGSHCELNINE 1386
            F C+ PP   +  +C    D CLS PC+N  TC  D    +RC C +G+ G  CE++++ 
Sbjct: 912  FECQGPPTLAVQAKC----DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDS 967

Query: 1387 CQSNPCRNQATC---VDELNSYSCKCQPGFSGKRC 1418
            C S PC N  TC     E   ++C C  GF G  C
Sbjct: 968  CSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTC 1002



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 38/127 (29%), Positives = 57/127 (44%), Gaps = 7/127 (5%)

Query: 1273 CSSSPCLNKGICV-DGVAGYRCTCVKGFVGLHCETEVN-ECQSNPCLNNAVCEDQVGGFL 1330
            C    CL+ GIC  +   G  C C  G+VGLHC+   +  C  + C++          + 
Sbjct: 1342 CRKLYCLH-GICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYS 1400

Query: 1331 CKCPPGFLGTRC---GKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINEC 1387
            C+C  G+ G  C   G   + C    C +G     G     C+C  GF+G  CE   +EC
Sbjct: 1401 CQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SEC 1459

Query: 1388 QSNPCRN 1394
            + +P R+
Sbjct: 1460 RGDPVRD 1466



 Score = 65.9 bits (159), Expect = 7e-10
 Identities = 41/113 (36%), Positives = 52/113 (46%), Gaps = 20/113 (17%)

Query: 3475 PCQNGGICQR------PNACSCPEGWMGRLC--EEPICI-LPCLNGGRCV---APYQCDC 3522
            PC+NGG C        P  CSCP G+ G  C      C+   C NGG CV     Y C C
Sbjct: 972  PCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQC 1031

Query: 3523 PPGWTGSRCHTAV--CQ---SPCLNGGKCV-RPN--RCHCLSSWTGHNCSRKR 3567
            P  + G  C   V  C    +PC +  +CV  P+  RC C+  + G NCS  +
Sbjct: 1032 PLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQ 1084



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 41/117 (35%), Positives = 49/117 (41%), Gaps = 19/117 (16%)

Query: 3468 CRAVCRFPCQNGGICQRPNA----CSCPEGWMGRLCEEPICIL---PCLNGGRCVA---- 3516
            C      PCQN G C         C+CP G+ GR CE  +      PC NGG C A    
Sbjct: 926  CDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGE 985

Query: 3517 --PYQCDCPPGWTGSRC--HTAVC-QSPCLNGGKC---VRPNRCHCLSSWTGHNCSR 3565
              P+ C CP G+ G  C  +T  C    C NGG C   V    C C   + G  C +
Sbjct: 986  DAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQ 1042



 Score = 62.4 bits (150), Expect = 8e-09
 Identities = 50/176 (28%), Positives = 68/176 (38%), Gaps = 13/176 (7%)

Query: 1206 GTCQQLGR-GYVCLCPLGYTGLKCETDID-ECSPLPCLNNGVCKDLVG-EFICECPSGYT 1262
            G CQ     G +C C  G+ GL C+   D  C    C+ +G C  L    + C+C  GY+
Sbjct: 1350 GICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCV-HGQCVPLDALSYSCQCQDGYS 1408

Query: 1263 GQRCEEN---INECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNN 1319
            G  C +       C    CL+      G  G  C C  GF G  CE E +EC+ +P  + 
Sbjct: 1409 GALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPVRD- 1466

Query: 1320 AVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGF 1375
               + Q G  +C+         C      C  Q C  G   K    +F C     F
Sbjct: 1467 -FHQVQRGYAICQTTRPLSWVECR---GSCPGQGCCQGLRLKRRKFTFECSDGTSF 1518



 Score = 48.9 bits (115), Expect = 9e-05
 Identities = 37/113 (32%), Positives = 53/113 (46%), Gaps = 22/113 (19%)

Query: 3466 PICRAVCRFPCQNGGICQRPNA-----CSCPEGWMGRLCEEPICILPCLNGGRCV----- 3515
            P C    +  C +G ICQ PNA     C C  GW+G  C++P    PC +G +CV     
Sbjct: 1337 PGCEPCRKLYCLHG-ICQ-PNATPGPMCHCEAGWVGLHCDQP-ADGPC-HGHKCVHGQCV 1392

Query: 3516 ----APYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRPNRCHCLSSWT-GHNC 3563
                  Y C C  G++G+ C+ A   +    G +C+     HC +S T G +C
Sbjct: 1393 PLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHG---HCQASGTKGAHC 1442



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 30/106 (28%), Positives = 46/106 (43%), Gaps = 9/106 (8%)

Query: 1316 CLNNAVCEDQVGGFL-CKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
            C+ N    +++  F   +  PG +        + C    C +G    +      C C AG
Sbjct: 1313 CIRNLYINNELQDFTKTQMKPGVV-----PGCEPCRKLYCLHGICQPNATPGPMCHCEAG 1367

Query: 1375 FTGSHCELNIN-ECQSNPC-RNQATCVDELNSYSCKCQPGFSGKRC 1418
            + G HC+   +  C  + C   Q   +D L SYSC+CQ G+SG  C
Sbjct: 1368 WVGLHCDQPADGPCHGHKCVHGQCVPLDAL-SYSCQCQDGYSGALC 1412



 Score = 42.7 bits (99), Expect = 0.006
 Identities = 25/71 (35%), Positives = 30/71 (42%), Gaps = 15/71 (21%)

Query: 3476 CQNGGICQ---RPNACSCPEGWMGRLCEEPICI---------LPCLNGGRCVAPYQ---C 3520
            CQNG  C       +C C EG+ G+LCE P  +           C NG  CV       C
Sbjct: 1092 CQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVC 1151

Query: 3521 DCPPGWTGSRC 3531
             C PG+ G  C
Sbjct: 1152 QCLPGFGGPEC 1162



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 47/162 (29%), Positives = 63/162 (38%), Gaps = 34/162 (20%)

Query: 277  CSYLCDEGKD-CCDRMGSCKCGTHTGHFECICEKGYYGKGLQY----------------E 319
            C    D+  D  C   G C  G   G++ C C   Y GK  +                 +
Sbjct: 1002 CGVNTDDCVDHACANGGVCVDGV--GNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQ 1059

Query: 320  CTACPSGTYKPEGSPG-GISSCIPCPDE--NHTSPPGSTSPED-----CVCREGYRASGQ 371
            C   P G  + E  PG    +C    D+  +H    G+   ++     C+C EGY  SGQ
Sbjct: 1060 CVGTPDGP-RCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGY--SGQ 1116

Query: 372  TCEL-VHCPALKPPENGYFIQN--TCNNHFNAACGVRCHPGF 410
             CE+  H PA K P  G   QN   C +  N     +C PGF
Sbjct: 1117 LCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPV-CQCLPGF 1157



 Score = 34.7 bits (78), Expect = 1.7
 Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 11/55 (20%)

Query: 3487 ACSCPEGWMGRLCE------EPICILPCLNGGRCVAP----YQCDCPPGWTGSRC 3531
            +C C +G+ G LC       EP   L CL+G  C A       C C PG++G  C
Sbjct: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLHG-HCQASGTKGAHCVCDPGFSGELC 1453



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 40/162 (24%), Positives = 51/162 (31%), Gaps = 34/162 (20%)

Query: 323  CPSGTYKPEGSPGGISSC------IPC------PDENHTSPPGSTSPED-----CVCREG 365
            C  G  +P  +PG +  C      + C      P   H    G   P D     C C++G
Sbjct: 1347 CLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDG 1406

Query: 366  YRASGQTCELVHCPALKPPENGY-FIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNG 424
            Y  SG  C      AL  P  G   +   C           C PGF            +G
Sbjct: 1407 Y--SGALCN--QAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGF------------SG 1450

Query: 425  LWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVAC 466
                 ES CR        Q + G+  C T   L    C  +C
Sbjct: 1451 ELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSC 1492



 Score = 33.1 bits (74), Expect = 5.1
 Identities = 38/128 (29%), Positives = 54/128 (42%), Gaps = 24/128 (18%)

Query: 3384 CREGFLLQGHGIITCNPDETWTQTSAKCEK----ISCGPPAHVENAIARGVHYQYG--DM 3437
            CR+ + L  HGI  C P+ T       CE     + C  PA       + VH Q    D 
Sbjct: 1342 CRKLYCL--HGI--CQPNAT-PGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDA 1396

Query: 3438 ITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGICQRPNA----CSCPEG 3493
            ++YSC      +G+  ++C + G    P  CR +    C +G  CQ        C C  G
Sbjct: 1397 LSYSCQCQ---DGYSGALCNQAGALAEP--CRGL---QCLHGH-CQASGTKGAHCVCDPG 1447

Query: 3494 WMGRLCEE 3501
            + G LCE+
Sbjct: 1448 FSGELCEQ 1455


>gi|122937283 6720455I24Rik homolog [Homo sapiens]
          Length = 1413

 Score =  204 bits (520), Expect = 1e-51
 Identities = 146/539 (27%), Positives = 200/539 (37%), Gaps = 129/539 (23%)

Query: 988  CRPGSVLRGRMCVNCPLGTYYNL--EHFTCESCRIGSYQDEEGQLECKL----------- 1034
            C P   L G  CV+  +G Y  L  E F    C  G +   +  L               
Sbjct: 391  CSPDPCLNGGSCVDL-VGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQ 449

Query: 1035 -----CPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTY----QPKFGSRS 1085
                 CP G        R   DC  +C+ G        T   CPLG +    + +  +  
Sbjct: 450  GYVCECPEGFMGLDCRERVPDDC--ECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMP 507

Query: 1086 C---LSCPENTSTVKRGAVNISACGV----------PCPEGKFSRSGLMPCHP------C 1126
            C     CP+    ++ G   +  C            PC        G    H       C
Sbjct: 508  CNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCEC 567

Query: 1127 PRDYYQPNAGKA---FCLA--CPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLG 1181
            PR ++  +  KA    C +  C   GT   AG      C      F+     +  P S  
Sbjct: 568  PRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPY---RFTGRHCEIGKPDS-- 622

Query: 1182 HIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCL 1241
                           C   PCHN GTC      Y C CP G++G  CE     C   PC+
Sbjct: 623  ---------------CASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCV 667

Query: 1242 NNGVCKDLVGEFICE-----------------------------------------CPSG 1260
            N G C+D   +F C                                          C  G
Sbjct: 668  NGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRG 727

Query: 1261 YT------------------GQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGL 1302
            Y+                    +C E I+EC S PCL+ G C D VAGY C C  G+ G 
Sbjct: 728  YSLSAPSRIRVCQPHGVWSEPPQCLE-IDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGA 786

Query: 1303 HCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKD 1362
            HCE E +EC+++PC N   C +  G ++C+CP GF+G  C   VD C S PC++G  C+ 
Sbjct: 787  HCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCES 846

Query: 1363 GANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
            G  ++ C+C   F G HCE   + C S+PC  +  C+    S+SC C+ G++G+ C  E
Sbjct: 847  GGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKE 905



 Score =  187 bits (474), Expect = 2e-46
 Identities = 98/269 (36%), Positives = 125/269 (46%), Gaps = 48/269 (17%)

Query: 1195 HECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
            +EC   PC N GTC      + C CP G+ G  CET    C    C + G C+   G  +
Sbjct: 313  NECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAV 372

Query: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCET----EVNE 1310
            C C +GYTG  CE ++++CS  PCLN G CVD V  Y C C + F GL CET      + 
Sbjct: 373  CVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDA 432

Query: 1311 CQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNV-DECLSQPCKNGATCKDGANSFRC 1369
            C S PC N   C D   G++C+CP GF+G  C + V D+C    C+NG  C  GAN+  C
Sbjct: 433  CLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDC---ECRNGGRCL-GANTTLC 488

Query: 1370 LCAAGFTGSHCELNI---------------------------------------NECQSN 1390
             C  GF G  CE  I                                       + C S+
Sbjct: 489  QCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSD 548

Query: 1391 PCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
            PC N  +C    +SY+C+C  GF GK CE
Sbjct: 549  PCFNGGSCDAHDDSYTCECPRGFHGKHCE 577



 Score =  173 bits (439), Expect = 2e-42
 Identities = 85/230 (36%), Positives = 111/230 (48%), Gaps = 13/230 (5%)

Query: 1201 PCHNSGTCQQL----GRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICE 1256
            PC N G C          Y C C  G+TG +C  D++EC+  PC N G C   +  F C+
Sbjct: 277  PCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQ 336

Query: 1257 CPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPC 1316
            CP+G+ G  CE   + C +  C + G C        C C  G+ G  CE +V++C  +PC
Sbjct: 337  CPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPC 396

Query: 1317 LNNAVCEDQVGGFLCKCPPGFLGTRCGKN----VDECLSQPCKNGATCKDGANSFRCLCA 1372
            LN   C D VG + C C   F G RC        D CLS PC NG TC D    + C C 
Sbjct: 397  LNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECP 456

Query: 1373 AGFTGSHCELNI-NECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
             GF G  C   + ++C+   CRN   C+   N+  C+C  GF G  CE E
Sbjct: 457  EGFMGLDCRERVPDDCE---CRNGGRCLG-ANTTLCQCPLGFFGLLCEFE 502



 Score =  152 bits (383), Expect = 7e-36
 Identities = 63/151 (41%), Positives = 81/151 (53%)

Query: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
            EC   PC + G+CQ    GY+CLC  GY G  CE + DEC   PC N G C++L G ++C
Sbjct: 756  ECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVC 815

Query: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP 1315
             CP+G+ G  CE  ++ C SSPC + G C  G   Y C C + F G HCET  + C S+P
Sbjct: 816  RCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSP 875

Query: 1316 CLNNAVCEDQVGGFLCKCPPGFLGTRCGKNV 1346
            C     C    G   C C  G+ G  C K +
Sbjct: 876  CGGRGYCLASNGSHSCTCKVGYTGEDCAKEL 906



 Score =  103 bits (257), Expect = 3e-21
 Identities = 156/625 (24%), Positives = 225/625 (36%), Gaps = 131/625 (20%)

Query: 2982 HGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGL 3041
            HG +S RC     + G +       C T   ++G       + G A  + C  G+     
Sbjct: 328  HGINSFRCQCPAGFGGPTCETAQSPCDTKECQHG--GQCQVENGSAVCV-CQAGY----- 379

Query: 3042 SEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSD 3101
            +   CE D    S  P     SC  L                 V  Y+C      +G   
Sbjct: 380  TGAACEMDVDDCSPDPCLNGGSCVDL-----------------VGNYTCLCAEPFKG--- 419

Query: 3102 LICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYT----MDTD 3157
            L C E G     +PV  P +C S P             Y  E    C EG+      +  
Sbjct: 420  LRC-ETG----DHPV--PDACLSAPCHNGGTCVDADQGYVCE----CPEGFMGLDCRERV 468

Query: 3158 TDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEG-YTFE-- 3214
             D   C+  GR     +  +   C  P     +L   +  ++   ++  C +G Y  E  
Sbjct: 469  PDDCECRNGGRC----LGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHG 524

Query: 3215 GVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYE-- 3272
            G  + VC  D            +  S   P   +  F  GS    + +   +C  G+   
Sbjct: 525  GSYLCVCHTDHN----------ASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGK 574

Query: 3273 -LEGNRERVCQENRQWSGGVAICKET----RCETPLEFLNGKADI---ENRTTGPNVVYS 3324
              E  R  +C      +GG   CKE      C  P  F     +I   ++  +GP     
Sbjct: 575  HCEKARPHLCSSGPCRNGGT--CKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGP----- 627

Query: 3325 CNRG---YSLEGPSEAHCTENGTWSHPVPLCK--PNPCPVPFVIP-ENALLSEKEFYVDQ 3378
            C+ G   +   G  +  C    +  H    C+  P+PC   F  P  N    E     D 
Sbjct: 628  CHNGGTCFHYIGKYKCDCPPGFSGRH----CEIAPSPC---FRSPCVNGGTCEDR---DT 677

Query: 3379 NVSIKCREGFLLQGHGIITCNPDETWTQTSAKCE-KISCGPPAHVENAIARGVHYQYGDM 3437
            +    C+ G++                    +C+ ++ CGPP  V++A  R    + G +
Sbjct: 678  DFFCHCQAGYM------------------GRRCQAEVDCGPPEEVKHATLRFNGTRLGAV 719

Query: 3438 ITYSCYSGYMLEGFLR-SVCLENGTWTSPPICRAV--CRF-PCQNGGICQRPNA---CSC 3490
              Y+C  GY L    R  VC  +G W+ PP C  +  CR  PC +GG CQ   A   C C
Sbjct: 720  ALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLC 779

Query: 3491 PEGWMGRLCE---EPICILPCLNGGRC---VAPYQCDCPPGWTGSRCHTAV--C-QSPCL 3541
              G+ G  CE   +     PC NGG C      Y C CP G+ G  C T V  C  SPC 
Sbjct: 780  STGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQ 839

Query: 3542 NGGKCVRPN---RCHCLSSWTGHNC 3563
            +GG+C        C C  S+ G++C
Sbjct: 840  HGGRCESGGGAYLCVCPESFFGYHC 864



 Score = 92.8 bits (229), Expect = 5e-18
 Identities = 41/87 (47%), Positives = 51/87 (58%), Gaps = 5/87 (5%)

Query: 1342 CGKNVDECLS-QPCKNGATCKD----GANSFRCLCAAGFTGSHCELNINECQSNPCRNQA 1396
            CG     CL+ +PC NG  C D    G  S+ C C +GFTG  C L++NEC S PC+N  
Sbjct: 265  CGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGG 324

Query: 1397 TCVDELNSYSCKCQPGFSGKRCETEQS 1423
            TC   +NS+ C+C  GF G  CET QS
Sbjct: 325  TCTHGINSFRCQCPAGFGGPTCETAQS 351



 Score = 91.3 bits (225), Expect = 2e-17
 Identities = 119/463 (25%), Positives = 167/463 (36%), Gaps = 86/463 (18%)

Query: 3151 GYTMDTDTDTFTCQKDGRWFPERISCSPK-KCPLPENITHILVHGDDFSVNRQVSVSCAE 3209
            G+T         C   G+   + ++ +P   C      T    H D   VN   S  C  
Sbjct: 266  GHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLD---VNECASQPCQN 322

Query: 3210 GYTF-EGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCE 3268
            G T   G+N   CQ    +  P  + + SP  C   E  +HG   G       + +  C+
Sbjct: 323  GGTCTHGINSFRCQCPAGFGGPTCETAQSP--CDTKEC-QHG---GQCQVENGSAVCVCQ 376

Query: 3269 PGYELEGNRERV--CQENRQWSGG---------VAICKET----RCET---PLEFLNGKA 3310
             GY        V  C  +   +GG           +C E     RCET   P+      A
Sbjct: 377  AGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSA 436

Query: 3311 DIENRTT----GPNVVYSCNRGYS-----LEGPSEAHCTENGTW-SHPVPLCKPNPCPVP 3360
               N  T        V  C  G+         P +  C   G        LC+   CP+ 
Sbjct: 437  PCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCECRNGGRCLGANTTLCQ---CPLG 493

Query: 3361 FVIPENALLSEKEFY-VDQNVSIKCREGFLLQGHG---IITCNPDETWTQTSAKCEKISC 3416
            F      LL E E   +  N++ +C +G     HG   +  C+ D   +         S 
Sbjct: 494  FF----GLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASH--------SL 541

Query: 3417 GPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPC 3476
              P   +     G    + D  T  C       GF    C +      P +C +    PC
Sbjct: 542  PSPCDSDPCFNGGSCDAHDDSYTCECP-----RGFHGKHCEK----ARPHLCSSG---PC 589

Query: 3477 QNGGICQRPNA---CSCPEGWMGRLCE----EPICILPCLNGGRC---VAPYQCDCPPGW 3526
            +NGG C+       CSCP  + GR CE    +     PC NGG C   +  Y+CDCPPG+
Sbjct: 590  RNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGF 649

Query: 3527 TGSRCHTA---VCQSPCLNGGKCVRPNR---CHCLSSWTGHNC 3563
            +G  C  A     +SPC+NGG C   +    CHC + + G  C
Sbjct: 650  SGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRC 692



 Score = 62.8 bits (151), Expect = 6e-09
 Identities = 73/272 (26%), Positives = 97/272 (35%), Gaps = 38/272 (13%)

Query: 1715 QCNNGYYLL---GDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICS 1771
            QC +G Y +   G     C  + + +   PS  D D C  G  C  H      D SY C 
Sbjct: 513  QCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAH------DDSYTCE 566

Query: 1772 CVPPYTGDGKNC--AEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMG------ 1823
            C  P    GK+C  A P  C + G   NG +  E    G E   SC   Y+  G      
Sbjct: 567  C--PRGFHGKHCEKARPHLCSS-GPCRNGGTCKE---AGGEYHCSCP--YRFTGRHCEIG 618

Query: 1824 ----VTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTL 1879
                     C   G   H I   K   C  P      C    +  F S     C  G T 
Sbjct: 619  KPDSCASGPCHNGGTCFHYIGKYKC-DC-PPGFSGRHCEIAPSPCFRSP----CVNGGTC 672

Query: 1880 AGDKESSCLANSSWSHSPPVCEP-VKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQ 1938
              D+++    +    +    C+  V C  PE + +     +G    + A Y+CD GYSL 
Sbjct: 673  E-DRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLS 731

Query: 1939 GPSIIE-CTASGIWDRAPPACHLVFCGEPPAI 1969
             PS I  C   G+W   P    +  C   P +
Sbjct: 732  APSRIRVCQPHGVWSEPPQCLEIDECRSQPCL 763



 Score = 58.9 bits (141), Expect = 9e-08
 Identities = 32/84 (38%), Positives = 40/84 (47%), Gaps = 13/84 (15%)

Query: 3493 GWMGRLCEEPICILPCLNGGRCV-------APYQCDCPPGWTGSRCHTAV--CQS-PCLN 3542
            G  G      + + PCLNGG+C+         Y C C  G+TG RCH  V  C S PC N
Sbjct: 263  GGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQN 322

Query: 3543 GGKC---VRPNRCHCLSSWTGHNC 3563
            GG C   +   RC C + + G  C
Sbjct: 323  GGTCTHGINSFRCQCPAGFGGPTC 346



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 43/157 (27%), Positives = 66/157 (42%), Gaps = 27/157 (17%)

Query: 1658 CDPGF-----QLVGNPV--QYCLNQGQW----TQPLPHCE----------RISCGVPPPL 1696
            C PGF     ++  +P     C+N G      T    HC+           + CG P  +
Sbjct: 645  CPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEV 704

Query: 1697 ENGFHSADDFYAGSTVTYQCNNGYYLLGDSRM-FCTDNGSWNGVSPSCLDVDECAVGSDC 1755
            ++     +    G+   Y C+ GY L   SR+  C  +G W+   P CL++DEC     C
Sbjct: 705  KHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWS-EPPQCLEIDECR-SQPC 762

Query: 1756 SEHASCLNVDGSYICSCVPPYTGDGKNC-AEPIKCKA 1791
                SC +    Y+C C   Y  +G +C  E  +C+A
Sbjct: 763  LHGGSCQDRVAGYLCLCSTGY--EGAHCELERDECRA 797



 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 18/33 (54%), Positives = 23/33 (69%)

Query: 1387 CQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
            C  NPC+N  TCV   +++SC C PGF G+RCE
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 25/66 (37%), Positives = 32/66 (48%), Gaps = 9/66 (13%)

Query: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCE---EPICILPCLNGGRCVA---PYQCDCPPG 3525
            PCQ+GG C+       C CPE + G  CE   +P    PC   G C+A    + C C  G
Sbjct: 837  PCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVG 896

Query: 3526 WTGSRC 3531
            +TG  C
Sbjct: 897  YTGEDC 902



 Score = 45.8 bits (107), Expect = 8e-04
 Identities = 50/209 (23%), Positives = 73/209 (34%), Gaps = 31/209 (14%)

Query: 1749 CAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVG 1808
            C+ G  C    +C    G Y CSC   +TG      +P  C A G   NG   G  +   
Sbjct: 584  CSSGP-CRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSC-ASGPCHNG---GTCFHYI 638

Query: 1809 AEVTFSCQEGY--QLMGVTKITCLESGEWN---------HLIPYCKA----------VSC 1847
             +    C  G+  +   +    C  S   N             +C+A          V C
Sbjct: 639  GKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDC 698

Query: 1848 GKPAIPENGCIEELAFTFGSKVTYRCNKGYTL-AGDKESSCLANSSWSHSPPVCEPVKCS 1906
            G P   ++  +       G+   Y C++GY+L A  +   C  +  WS  P   E  +C 
Sbjct: 699  GPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECR 758

Query: 1907 SPENINNGKYILSGLTYLSTASYSCDTGY 1935
            S   ++ G        YL      C TGY
Sbjct: 759  SQPCLHGGSCQDRVAGYLCL----CSTGY 783



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 20/44 (45%), Positives = 24/44 (54%), Gaps = 1/44 (2%)

Query: 1349 CLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPC 1392
            C   PC+NG TC  GA++  C C  GF G  CEL   +  S PC
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKV-SRPC 1353



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 58/245 (23%), Positives = 85/245 (34%), Gaps = 66/245 (26%)

Query: 281 CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGK------------------------GL 316
           CD   D C   GSC    H   + C C +G++GK                        G 
Sbjct: 545 CDS--DPCFNGGSCDA--HDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGG 600

Query: 317 QYECTACP---SGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTC 373
           +Y C+ CP   +G +   G P    SC   P  N  +         C C  G+  SG+ C
Sbjct: 601 EYHCS-CPYRFTGRHCEIGKP---DSCASGPCHNGGTCFHYIGKYKCDCPPGF--SGRHC 654

Query: 374 ELVHCPALKPP-ENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESY 432
           E+   P  + P  NG   ++   + F       CH     +G                  
Sbjct: 655 EIAPSPCFRSPCVNGGTCEDRDTDFF-------CHCQAGYMGRR---------------- 691

Query: 433 CRVRT-CPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKL-TCQGNSQWDGPE 490
           C+    C    + KH  +  +   +      L ACD GY L    ++  CQ +  W  P 
Sbjct: 692 CQAEVDCGPPEEVKHATLRFNGTRL--GAVALYACDRGYSLSAPSRIRVCQPHGVWSEP- 748

Query: 491 PRCVE 495
           P+C+E
Sbjct: 749 PQCLE 753



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 52/200 (26%), Positives = 68/200 (34%), Gaps = 36/200 (18%)

Query: 2873 CLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQ 2932
            C     +SG   +  P  C   P +  G  E  D  F      HC  GY+        CQ
Sbjct: 643  CDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFF----CHCQAGYMGR-----RCQ 693

Query: 2933 SDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSS-RRCLS 2991
            ++            V+CGPPE++ H          G    Y C  GY L   S  R C  
Sbjct: 694  AE------------VDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQP 741

Query: 2992 NGSWSGSSPSCL---PCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEA 3048
            +G WS   P CL    CR S P +  G+            R+  +      G     CE 
Sbjct: 742  HGVWS-EPPQCLEIDECR-SQPCLHGGSCQD---------RVAGYLCLCSTGYEGAHCEL 790

Query: 3049 DGQWSSGFPHCEHTSCGSLP 3068
            +       P     SC +LP
Sbjct: 791  ERDECRAHPCRNGGSCRNLP 810



 Score = 42.7 bits (99), Expect = 0.006
 Identities = 78/373 (20%), Positives = 120/373 (32%), Gaps = 74/373 (19%)

Query: 1746 VDECAVGSDCSEHASCLNVDGSYICSCVPPYTG--------------DGKNC--AEPIKC 1789
            V +  + + C    +C++ D  Y+C C   + G              +G  C  A    C
Sbjct: 429  VPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCECRNGGRCLGANTTLC 488

Query: 1790 KAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGK 1849
            + P          EI  +   +   C +G          C+E G     +  C       
Sbjct: 489  QCPLGFFGLLCEFEITAMPCNMNTQCPDGGY--------CMEHG--GSYLCVCHTDHNAS 538

Query: 1850 PAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPE 1909
             ++P + C  +  F  GS   +  +  YT        C       H      P  CSS  
Sbjct: 539  HSLP-SPCDSDPCFNGGSCDAH--DDSYTC------ECPRGFHGKHCEKA-RPHLCSSGP 588

Query: 1910 NINNGKYILSGLTYLSTASY-------------SCDTGYSLQGPSIIECTASGIWDRAPP 1956
              N G    +G  Y  +  Y             SC +G    G +          D  PP
Sbjct: 589  CRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCD-CPP 647

Query: 1957 ACHLVFC--GEPPAIKDAVITGNNFTFRNTVTYT-CKEGYTLAGLDTIECLADGKWSRSD 2013
                  C     P  +   + G     R+T  +  C+ GY                    
Sbjct: 648  GFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYM------------------G 689

Query: 2014 QQCLA-VSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQL-LCNAQGKW-VPP 2070
            ++C A V C  P  V HA+        G +A Y C  GYSL+  S++ +C   G W  PP
Sbjct: 690  RRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPP 749

Query: 2071 EGQDMPRCIAHFC 2083
            +  ++  C +  C
Sbjct: 750  QCLEIDECRSQPC 762



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 52/197 (26%), Positives = 70/197 (35%), Gaps = 35/197 (17%)

Query: 281 CDEGKDCCDRMGSCK----CGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGG 336
           C+ GK      G C     C  + G ++C C  G+ G+     C   PS  ++     GG
Sbjct: 615 CEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGR----HCEIAPSPCFRSPCVNGG 670

Query: 337 ISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCEL-VHCPALKPPENGYFIQNTCN 395
                 C D +        +   C C+ GY   G+ C+  V C    PPE         N
Sbjct: 671 T-----CEDRD--------TDFFCHCQAGYM--GRRCQAEVDCG---PPEEVKHATLRFN 712

Query: 396 N-HFNAACGVRCHPGFDLVGSSII-LCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCST 453
                A     C  G+ L   S I +C P+G+WS       +  C    QP     SC  
Sbjct: 713 GTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDEC--RSQPCLHGGSCQD 770

Query: 454 REMLYKTTCLVACDEGY 470
           R   Y    L  C  GY
Sbjct: 771 RVAGY----LCLCSTGY 783



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 19/44 (43%), Positives = 22/44 (50%), Gaps = 1/44 (2%)

Query: 1273 CSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPC 1316
            CS +PC N G CV G   + C C  GF G  CE    +  S PC
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKV-SRPC 1353



 Score = 40.8 bits (94), Expect = 0.024
 Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 5/92 (5%)

Query: 2715 IECDLPTAPENGFLRFTETSMGSAVQYSCKPGHIL-AGSDLRLCLENRKWSGASPRCEAI 2773
            ++C  P   ++  LRF  T +G+   Y+C  G+ L A S +R+C  +  WS   P+C  I
Sbjct: 696  VDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWS-EPPQCLEI 754

Query: 2774 SCKKPNPVMNGSIKGSNYTYLSTLYYECDPGY 2805
               +  P ++G   GS    ++     C  GY
Sbjct: 755  DECRSQPCLHG---GSCQDRVAGYLCLCSTGY 783



 Score = 40.4 bits (93), Expect = 0.032
 Identities = 25/77 (32%), Positives = 36/77 (46%), Gaps = 4/77 (5%)

Query: 2769 RCEA-ISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTER-RTCQDDKNWDEDEP 2826
            RC+A + C  P  V + +++ +     +   Y CD GY L+   R R CQ    W E  P
Sbjct: 691  RCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSE-PP 749

Query: 2827 ICIPVD-CSSPPVSANG 2842
             C+ +D C S P    G
Sbjct: 750  QCLEIDECRSQPCLHGG 766



 Score = 40.0 bits (92), Expect = 0.041
 Identities = 53/230 (23%), Positives = 87/230 (37%), Gaps = 49/230 (21%)

Query: 2142 IPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKS--------------TC- 2186
            +P  C   P    G     + S+       C +GF+ K  +K+              TC 
Sbjct: 541  LPSPCDSDPCFNGGSCDAHDDSYTC----ECPRGFHGKHCEKARPHLCSSGPCRNGGTCK 596

Query: 2187 EATGQWSSPIP---TCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCN--PGYKS---- 2237
            EA G++    P   T      G+P    +G   H  G  F    +Y+C+  PG+      
Sbjct: 597  EAGGEYHCSCPYRFTGRHCEIGKPDSCASGPC-HNGGTCFHYIGKYKCDCPPGFSGRHCE 655

Query: 2238 -VGSPVF--------VCQ---ANRHWHSESPLM---C-VPLDCGKPPPIQNGFMKGENFE 2281
               SP F         C+    +   H ++  M   C   +DCG P  +++  ++     
Sbjct: 656  IAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTR 715

Query: 2282 VGSKVQFFCNEGYELVGDSS-WTCQKSGKWNKKSNPKCMPA-KCPEPPLL 2329
            +G+   + C+ GY L   S    CQ  G W++   P+C+   +C   P L
Sbjct: 716  LGAVALYACDRGYSLSAPSRIRVCQPHGVWSEP--PQCLEIDECRSQPCL 763



 Score = 40.0 bits (92), Expect = 0.041
 Identities = 25/93 (26%), Positives = 42/93 (45%), Gaps = 5/93 (5%)

Query: 2475 NTTTLCGENGHWLGGKPTCKA-IECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGP 2533
            +T   C     ++G +  C+A ++C  P+E+ +    +     G    Y+C+RG+ L  P
Sbjct: 676  DTDFFCHCQAGYMGRR--CQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAP 733

Query: 2534 SAL-TCLETGDWDVDAPSCNAIHCDSPQPIENG 2565
            S +  C   G W  + P C  I     QP  +G
Sbjct: 734  SRIRVCQPHGVWS-EPPQCLEIDECRSQPCLHG 765



 Score = 38.9 bits (89), Expect = 0.092
 Identities = 23/63 (36%), Positives = 29/63 (46%), Gaps = 10/63 (15%)

Query: 3475 PCQNGGIC---QRPNACSCPEGWMGRLCEEPICILPCLNGGR-CVAPY-QCDCPPGWTGS 3529
            PCQNGG C      ++C C  G+ GR CE     L C+   R C   + +    P W G 
Sbjct: 1315 PCQNGGTCVPGADAHSCDCGPGFKGRRCE-----LACIKVSRPCTRLFSETKAFPVWEGG 1369

Query: 3530 RCH 3532
             CH
Sbjct: 1370 VCH 1372



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 18/39 (46%), Positives = 21/39 (53%), Gaps = 5/39 (12%)

Query: 3507 PCLNGGRCVA---PYQCDCPPGWTGSRCHTAVCQ--SPC 3540
            PC NGG CV     + CDC PG+ G RC  A  +   PC
Sbjct: 1315 PCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPC 1353



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 17/44 (38%), Positives = 20/44 (45%), Gaps = 1/44 (2%)

Query: 1311 CQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPC 1354
            C  NPC N   C        C C PGF G RC     + +S+PC
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIK-VSRPC 1353



 Score = 37.4 bits (85), Expect = 0.27
 Identities = 26/93 (27%), Positives = 39/93 (41%), Gaps = 8/93 (8%)

Query: 2381 CTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTT-LCQPDGTWSSPLPECVPV- 2438
            C PP  +     +  +    G+   Y+C  G+ L   S   +CQP G WS P P+C+ + 
Sbjct: 698  CGPPEEVKHAT-LRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEP-PQCLEID 755

Query: 2439 ECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFE 2471
            EC     +  G    +   YL      C  G+E
Sbjct: 756  ECRSQPCLHGGSCQDRVAGYLC----LCSTGYE 784



 Score = 37.4 bits (85), Expect = 0.27
 Identities = 38/130 (29%), Positives = 47/130 (36%), Gaps = 26/130 (20%)

Query: 276 HCSYLCDEGK-DCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEG-- 332
           HC    DE +   C   GSC+     G + C C  G+ G   + E  AC S   +  G  
Sbjct: 787 HCELERDECRAHPCRNGGSCR--NLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRC 844

Query: 333 -SPGGISSCIPCP------------DENHTSPPG-------STSPEDCVCREGYRASGQT 372
            S GG   C+ CP            D   +SP G       S     C C+ GY      
Sbjct: 845 ESGGGAYLCV-CPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCA 903

Query: 373 CELVHCPALK 382
            EL    ALK
Sbjct: 904 KELFPPTALK 913



 Score = 36.6 bits (83), Expect = 0.46
 Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 3/77 (3%)

Query: 2551 CNA-IHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQV-AGHAMQTCEESGWSSSIPTC 2608
            C A + C  P+ +++  +       GA+ +Y+C  G+ + A   ++ C+  G  S  P C
Sbjct: 692  CQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQC 751

Query: 2609 MPID-CGLPPHIDFGDC 2624
            + ID C   P +  G C
Sbjct: 752  LEIDECRSQPCLHGGSC 768



 Score = 36.6 bits (83), Expect = 0.46
 Identities = 14/33 (42%), Positives = 17/33 (51%)

Query: 1235 CSPLPCLNNGVCKDLVGEFICECPSGYTGQRCE 1267
            CS  PC N G C        C+C  G+ G+RCE
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343



 Score = 35.8 bits (81), Expect = 0.78
 Identities = 19/61 (31%), Positives = 22/61 (36%), Gaps = 11/61 (18%)

Query: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETD-----------IDECSPLPCLNNGV 1245
            C  NPC N GTC      + C C  G+ G +CE               E    P    GV
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGV 1370

Query: 1246 C 1246
            C
Sbjct: 1371 C 1371



 Score = 35.0 bits (79), Expect = 1.3
 Identities = 20/71 (28%), Positives = 33/71 (46%), Gaps = 2/71 (2%)

Query: 2438 VECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFEL-VGNTTTLCGENGHWLGGKPTCKAI 2496
            V+C  PEE+ +  +   G    + ALY C  G+ L   +   +C  +G W    P C  I
Sbjct: 696  VDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVW-SEPPQCLEI 754

Query: 2497 ECLKPKEILNG 2507
            +  + +  L+G
Sbjct: 755  DECRSQPCLHG 765



 Score = 34.7 bits (78), Expect = 1.7
 Identities = 30/122 (24%), Positives = 44/122 (36%), Gaps = 18/122 (14%)

Query: 266 SGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPS 325
           +G+  + D+  CS       D C   GSC      G++ C+C + + G   +      P 
Sbjct: 380 TGAACEMDVDDCS------PDPCLNGGSCV--DLVGNYTCLCAEPFKGLRCETGDHPVPD 431

Query: 326 GTYKPEGSPGGISSCIP--------CPDENHTSPPGSTSPEDCVCREGYRASGQTCELVH 377
                    GG  +C+         CP+           P+DC CR G R  G    L  
Sbjct: 432 ACLSAPCHNGG--TCVDADQGYVCECPEGFMGLDCRERVPDDCECRNGGRCLGANTTLCQ 489

Query: 378 CP 379
           CP
Sbjct: 490 CP 491



 Score = 32.3 bits (72), Expect = 8.6
 Identities = 24/90 (26%), Positives = 40/90 (44%), Gaps = 17/90 (18%)

Query: 1743 CLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPI---------KCKAPG 1793
            C  V +    S C     CL  +GS+ C+C   YTG+  +CA+ +         + +  G
Sbjct: 864  CETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGE--DCAKELFPPTALKMERVEESG 921

Query: 1794 -----NPENGHSSGEIYTVGAEVTFSCQEG 1818
                 NP NG ++ ++   G  VT+   +G
Sbjct: 922  VSISWNPPNGPAARQMLD-GYAVTYVSSDG 950


>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
            sapiens]
          Length = 569

 Score =  197 bits (502), Expect = 1e-49
 Identities = 140/480 (29%), Positives = 206/480 (42%), Gaps = 46/480 (9%)

Query: 2711 SCISIECD----LPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGA 2766
            S  S +C+    LP A         E  +G+ + Y C+PG+      + +CL+N  W+ A
Sbjct: 29   SSFSDQCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTSA 87

Query: 2767 SPRCEAISCKKPNPVMNGSIKG-SNYTYLSTLYYECDPGYVLNGTERRTCQDDKN---WD 2822
              +C+  SC+ P   +NG      +  + S + Y C  GY L G+   TC    N   WD
Sbjct: 88   KDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWD 147

Query: 2823 EDEPICIPVDCSSPPVSANGQ---VRGDEYTFQKEIEYTCNEG------FLLEGARSRVC 2873
               P+C  + C  PP  ANG    +  + + +   + Y CN G      F L G  S  C
Sbjct: 148  NKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYC 207

Query: 2874 LAN----GSWSGATPDCVPVRCATPPQLANGVTEGLD---YGFMKEVTFHCHEGYILHGA 2926
             +     G WSG  P C+     TPP + NG+    +   +   + V F C  G+ + G 
Sbjct: 208  TSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGP 267

Query: 2927 PKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFP---NGFSFIHGGHIQYQCFPGYKLHG 2983
              + CQ+   W+ E+P C  V C PP D+ H      +  +F  G  + Y C PGY L G
Sbjct: 268  SHVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 326

Query: 2984 NSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNG-----TDFDCGKAARIQCFKGFKL 3038
            ++   C   G WS ++P C    C   + +    NG      +   G      C +GF+L
Sbjct: 327  STYLHCTPQGDWSPAAPRCEVKSCDDFLGQ--LPNGHVLFPLNLQLGAKVDFVCDEGFQL 384

Query: 3039 LGLSEITCEADGQ---WSSGFPHCEHTSCGSLPMIPNAFISE-TSSWKENVITYSCRSGY 3094
             G S   C   G    W+S  P CE  SC + P+  N  +   T     + I YSC +G+
Sbjct: 385  KGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGH 444

Query: 3095 VIQGSSDLICTEKG---VWSQPYPVCEPLSCGSPPSVANAVATGEA---HTYESEVKLRC 3148
             + G S   C   G    WS   P+C+ + C +PP++ N   TG       Y  EV   C
Sbjct: 445  RLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTC 504



 Score =  196 bits (498), Expect = 3e-49
 Identities = 137/480 (28%), Positives = 210/480 (43%), Gaps = 46/480 (9%)

Query: 1859 EELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKC-SSPENINNGKYI 1917
            ++  F  G+ + Y C  GY+        CL NS W+ +   C+   C + P+ +N   ++
Sbjct: 51   DDFEFPIGTYLNYECRPGYS-GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHV 109

Query: 1918 LSGLTYLSTASYSCDTGYSLQGPSIIECTASG---IWDRAPPACHLVFCGEPPAIKDAVI 1974
            +  + + S   YSC  GY L G S   C  SG   IWD   P C  + CG PP I +   
Sbjct: 110  IKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDF 169

Query: 1975 TG---NNFTFRNTVTYTC------KEGYTLAGLDTIECLAD----GKWSRSDQQCLAVSC 2021
            T      F + + VTY C      K+ + L G  +I C +     G WS    QC+  + 
Sbjct: 170  TSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNK 229

Query: 2022 DEPPIVDHASPETAHR-LF--GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRC 2078
              PP V++    + +R LF   ++  + C  G+ +   S + C A  KW P    ++P C
Sbjct: 230  CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEP----ELPSC 285

Query: 2079 IAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMS 2138
             +  C+ PP V ++      K  F+ G  V + C  G+ L  S  + C   G W  SP +
Sbjct: 286  -SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDW--SPAA 342

Query: 2139 IQCIPVRCGE-PPSIMNGYA-SGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQ---WS 2193
             +C    C +    + NG+     N   GA V + C++GF +KG   S C   G    W+
Sbjct: 343  PRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN 402

Query: 2194 SPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQAN---RH 2250
            S +P C   SC  PP   NG +   T     S + Y C  G++ +G     C  +    H
Sbjct: 403  SSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAH 462

Query: 2251 WHSESPLMCVPLDCGKPPPIQNGFMKGE---NFEVGSKVQFFCNE------GYELVGDSS 2301
            W S  P +C  + C  PP I NG   G    +   G +V + C+        + L+G+S+
Sbjct: 463  W-SMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGEST 521



 Score =  183 bits (464), Expect = 3e-45
 Identities = 150/567 (26%), Positives = 225/567 (39%), Gaps = 92/567 (16%)

Query: 2381 CTPPPLISFGVPIPSS---ALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVP 2437
            C  P  + F  P   +       G+ + Y C  G+  R  S  +C  +  W+S   +C  
Sbjct: 35   CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTSAKDKCKR 93

Query: 2438 VECPQPEEIPNGIIDV-QGLAYLSTALYTCKPGFELVGNTTTLCGENGH---WLGGKPTC 2493
              C  P +  NG+  V + + + S   Y+C  G+ L+G+++  C  +G+   W    P C
Sbjct: 94   KSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153

Query: 2494 KAIECLKPKEILNGKFSYTD---LHYGQTVTYSCNRG------FRLEGPSALTCL----E 2540
              I C  P  I NG F+       HYG  VTY CN G      F L G  ++ C     +
Sbjct: 154  DRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQ 213

Query: 2541 TGDWDVDAPSCNAIHCDSPQPIENGFVEGAD---YSYGAIIIYSCFPGFQVAGHAMQTCE 2597
             G W   AP C   +  +P  +ENG +   +   +S   ++ + C PGF + G +   C+
Sbjct: 214  VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQ 273

Query: 2598 E-SGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGA 2656
              + W   +P+C  + C  PP +   + T+   D                          
Sbjct: 274  ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKD-------------------------- 306

Query: 2657 VAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIE 2716
                             NF  G  V Y+C PGY+L G+  L C   G W+ +AP C    
Sbjct: 307  -----------------NFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKS 349

Query: 2717 CD--LPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCL---ENRKWSGASPRCE 2771
            CD  L   P    L      +G+ V + C  G  L GS    C+       W+ + P CE
Sbjct: 350  CDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 409

Query: 2772 AISCKKPNPVMNGSIKGSNYTYL-STLYYECDPGYVLNGTERRTC---QDDKNWDEDEPI 2827
              SC+ P   +NG +      ++ S + Y C  G+ L G     C    +  +W    PI
Sbjct: 410  RKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPI 469

Query: 2828 CIPVDCSSPPVSANGQVRG---DEYTFQKEIEYTCNE------GFLLEG----ARSRVCL 2874
            C  + C +PP   NG+  G    +  + KE+ YTC+        F L G     R+    
Sbjct: 470  CQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPH 529

Query: 2875 ANGSWSGATPDC-VPVRCATPPQLANG 2900
             NG WS   P C +PV   +   L  G
Sbjct: 530  GNGVWSSPAPRCELPVGAGSHDALIVG 556



 Score =  182 bits (462), Expect = 5e-45
 Identities = 128/434 (29%), Positives = 195/434 (44%), Gaps = 66/434 (15%)

Query: 1646 EDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQ---WTQPLPHCERISCGVPPPLENGFH- 1701
            +D++  S++   C  G++L+G+    C+  G    W    P C+RI CG+PP + NG   
Sbjct: 111  KDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170

Query: 1702 --SADDFYAGSTVTYQCNNG------YYLLGDSRMFCTDN----GSWNGVSPSCLDVDEC 1749
              S + F+ GS VTY CN G      + L+G+  ++CT      G W+G +P C+  ++C
Sbjct: 171  SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKC 230

Query: 1750 AV-----GSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKA-----PGNP---- 1795
                   G   S++ S  +++      C P   G G      +KC+A     P  P    
Sbjct: 231  TPPNVENGILVSDNRSLFSLNEVVEFRCQP---GFGMKGPSHVKCQALNKWEPELPSCSR 287

Query: 1796 -----------ENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKA 1844
                       E      + ++ G EV +SC+ GY L G T + C   G+W+   P C+ 
Sbjct: 288  VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEV 347

Query: 1845 VSCGK--PAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCL---ANSSWSHSPPV 1899
             SC      +P    +  L    G+KV + C++G+ L G   S C+     S W+ S PV
Sbjct: 348  KSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV 407

Query: 1900 CEPVKCSSPE-NINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASG---IWDRAP 1955
            CE   C +P   +N   ++++ +   S  +YSC TG+ L G S  EC  SG    W   P
Sbjct: 408  CERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKP 467

Query: 1956 PACHLVFCGEPPAIKDAVITG---NNFTFRNTVTYTCKE------GYTLAGLDTI----E 2002
            P C  +FC  PPAI +   TG    +  +   V+YTC         + L G  TI    E
Sbjct: 468  PICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSE 527

Query: 2003 CLADGKWSRSDQQC 2016
               +G WS    +C
Sbjct: 528  PHGNGVWSSPAPRC 541



 Score =  181 bits (460), Expect = 9e-45
 Identities = 153/521 (29%), Positives = 214/521 (41%), Gaps = 60/521 (11%)

Query: 2021 CDEPPIVDHASPETAHRLF----GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMP 2076
            C+ P  +  A P      F    G    Y C  GYS    S ++C     W   +     
Sbjct: 35   CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFS-IICLKNSVWTSAKD---- 89

Query: 2077 RCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQ---W- 2132
            +C    C  PP     +   +   +F   S + + C +G+ L  S+   C+  G    W 
Sbjct: 90   KCKRKSCRNPPDPVNGMAHVIKDIQFR--SQIKYSCPKGYRLIGSSSATCIISGNTVIWD 147

Query: 2133 NPSPMSIQCIPVRCGEPPSIMNG---YASGSNYSFGAMVAYSCNKG------FYIKGEKK 2183
            N +P+   C  + CG PP+I NG     S   + +G++V Y CN G      F + GE  
Sbjct: 148  NKTPV---CDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPS 204

Query: 2184 STC----EATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESE--VRYQCNPGYKS 2237
              C    +  G WS P P C   +   PP VENG L      +F     V ++C PG+  
Sbjct: 205  IYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGM 264

Query: 2238 VGSPVFVCQANRHWHSESPLMCVPLDCGKPPPI---QNGFMKGENFEVGSKVQFFCNEGY 2294
             G     CQA   W  E P  C  + C  PP +   +      +NF  G +V + C  GY
Sbjct: 265  KGPSHVKCQALNKWEPELP-SCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 322

Query: 2295 ELVGDSSWTCQKSGKWNKKSNPKCMPAKCPE-PPLLENQLVLKELTTEVGV-VTFSCKEG 2352
            +L G +   C   G W+  + P+C    C +    L N  VL  L  ++G  V F C EG
Sbjct: 323  DLRGSTYLHCTPQGDWSPAA-PRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEG 381

Query: 2353 HVLQGPSVLKCLPSQQ---WNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCV 2409
              L+G S   C+ +     WN S PVC+   C  PP+   G+    + +H GS + YSC 
Sbjct: 382  FQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCT 441

Query: 2410 GGFFLRGNSTTLCQPDGT---WSSPLPECVPVECPQPEEIPNGI---IDVQGLAYLSTAL 2463
             G  L G+S+  C   G    WS   P C  + CP P  I NG      +  + Y     
Sbjct: 442  TGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVS 501

Query: 2464 YTCKP------GFELVGNTTTLCGE----NGHWLGGKPTCK 2494
            YTC P       F L+G +T         NG W    P C+
Sbjct: 502  YTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542



 Score =  175 bits (444), Expect = 6e-43
 Identities = 140/490 (28%), Positives = 210/490 (42%), Gaps = 67/490 (13%)

Query: 1767 SYICSCVPPYTGDGKNCAEPIKCKAPGNPENG--HSSGEIYTVGAEVTFSCQEGYQLMGV 1824
            S IC     +T     C     C+ P +P NG  H   +I    +++ +SC +GY+L+G 
Sbjct: 75   SIICLKNSVWTSAKDKCKRK-SCRNPPDPVNGMAHVIKDIQ-FRSQIKYSCPKGYRLIGS 132

Query: 1825 TKITCLESGE---WNHLIPYCKAVSCGKPAIPENGCIEELA---FTFGSKVTYRCNKG-- 1876
            +  TC+ SG    W++  P C  + CG P    NG    ++   F +GS VTY CN G  
Sbjct: 133  SSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSR 192

Query: 1877 ----YTLAGDKESSCLANSS----WSHSPPVCE-PVKCSSPENINNGKYILSGLTYLS-- 1925
                + L G+    C +       WS   P C  P KC+ P N+ NG  +    +  S  
Sbjct: 193  GKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPP-NVENGILVSDNRSLFSLN 251

Query: 1926 -TASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITG---NNFTF 1981
                + C  G+ ++GPS ++C A   W+   P+C  V C  PP +  A  T    +NF+ 
Sbjct: 252  EVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSP 310

Query: 1982 RNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLF-- 2039
               V Y+C+ GY L G   + C   G WS +  +C   SCD+            H LF  
Sbjct: 311  GQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDD----FLGQLPNGHVLFPL 366

Query: 2040 ----GDIAFYYCSDGYSLADNSQLLCNAQGK---WVPPEGQDMPRCIAHFCEKPPSVSYS 2092
                G    + C +G+ L  +S   C   G    W       +P C    CE PP     
Sbjct: 367  NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLW----NSSVPVCERKSCETPPVPVNG 422

Query: 2093 ILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGG---QWNPSPMSIQCIPVRCGEP 2149
            ++  ++      GS +++ C  G  L   +  EC+  G    W+  P    C  + C  P
Sbjct: 423  MVHVIT--DIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPI--CQQIFCPNP 478

Query: 2150 PSIMNGYASGS---NYSFGAMVAYSCN------KGFYIKGE----KKSTCEATGQWSSPI 2196
            P+I+NG  +G+   +  +G  V+Y+C+        F + GE    + S     G WSSP 
Sbjct: 479  PAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPA 538

Query: 2197 PTCH-PVSCG 2205
            P C  PV  G
Sbjct: 539  PRCELPVGAG 548



 Score =  174 bits (440), Expect = 2e-42
 Identities = 128/465 (27%), Positives = 197/465 (42%), Gaps = 34/465 (7%)

Query: 1891 SSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGI 1950
            SS+S    V E +  + P N+ +      G TYL+   Y C  GYS +  SII C  + +
Sbjct: 29   SSFSDQCNVPEWLPFARPTNLTDDFEFPIG-TYLN---YECRPGYSGRPFSII-CLKNSV 83

Query: 1951 WDRAPPACHLVFCGEPP-AIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGK- 2008
            W  A   C    C  PP  +        +  FR+ + Y+C +GY L G  +  C+  G  
Sbjct: 84   WTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNT 143

Query: 2009 --WSRSDQQCLAVSCDEPPIV---DHASPETAHRLFGDIAFYYCSDG------YSLADNS 2057
              W      C  + C  PP +   D  S    +  +G +  Y+C+ G      + L    
Sbjct: 144  VIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEP 203

Query: 2058 QLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFV 2117
             + C ++   V       P+CI      PP+V   IL S +++ F+   VV F+C  GF 
Sbjct: 204  SIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFG 263

Query: 2118 LNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNG---YASGSNYSFGAMVAYSCNK 2174
            +   + ++C    +W P   S   +   C  PP +++         N+S G  V YSC  
Sbjct: 264  MKGPSHVKCQALNKWEPELPSCSRV---CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEP 320

Query: 2175 GFYIKGEKKSTCEATGQWSSPIPTCHPVSCGE-PPKVENGFLEHTTGRIFESEVRYQCNP 2233
            G+ ++G     C   G WS   P C   SC +   ++ NG +         ++V + C+ 
Sbjct: 321  GYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDE 380

Query: 2234 GYKSVGSPVFVC---QANRHWHSESPLMCVPLDCGKPPPIQNGFMKG-ENFEVGSKVQFF 2289
            G++  GS    C        W+S  P +C    C  PP   NG +    +  VGS++ + 
Sbjct: 381  GFQLKGSSASYCVLAGMESLWNSSVP-VCERKSCETPPVPVNGMVHVITDIHVGSRINYS 439

Query: 2290 CNEGYELVGDSSWTCQKSGK---WNKKSNPKCMPAKCPEPPLLEN 2331
            C  G+ L+G SS  C  SG    W+ K  P C    CP PP + N
Sbjct: 440  CTTGHRLIGHSSAECILSGNTAHWSMKP-PICQQIFCPNPPAILN 483



 Score =  165 bits (417), Expect = 9e-40
 Identities = 130/452 (28%), Positives = 184/452 (40%), Gaps = 48/452 (10%)

Query: 2949 CGPPEDLAHGFPNG----FSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLP 3004
            C  PE L    P      F F  G ++ Y+C PGY     S   CL N  W+ +   C  
Sbjct: 35   CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKR 93

Query: 3005 CRCSTPVIEYGTVNGT-----DFDCGKAARIQCFKGFKLLGLSEITCEADGQ---WSSGF 3056
              C  P      VNG      D       +  C KG++L+G S  TC   G    W +  
Sbjct: 94   KSCRNPP---DPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKT 150

Query: 3057 PHCEHTSCGSLPMIPNA---FISETSSWKENVITYSCRSG------YVIQGSSDLICTEK 3107
            P C+   CG  P I N     IS       +V+TY C  G      + + G   + CT K
Sbjct: 151  PVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSK 210

Query: 3108 ----GVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYES---EVKLRCLEGYTMDTDTDT 3160
                G+WS P P C   +  +PP+V N +   +  +  S    V+ RC  G+ M   +  
Sbjct: 211  DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHV 270

Query: 3161 FTCQKDGRWFPERISCSPKKCPLPENITHI---LVHGDDFSVNRQVSVSCAEGYTFEGVN 3217
              CQ   +W PE  SCS + C  P ++ H        D+FS  ++V  SC  GY   G  
Sbjct: 271  -KCQALNKWEPELPSCS-RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGST 328

Query: 3218 ISVCQLDGTWEPPFSDESCSPVSCGK--PESPEHGFVVGSKYTFESTIIYQCEPGYELEG 3275
               C   G W P  +   C   SC     + P    +        + + + C+ G++L+G
Sbjct: 329  YLHCTPQGDWSP--AAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKG 386

Query: 3276 NRERVCQ---ENRQWSGGVAICKETRCETPLEFLNGKAD-IENRTTGPNVVYSCNRGYSL 3331
            +    C        W+  V +C+   CETP   +NG    I +   G  + YSC  G+ L
Sbjct: 387  SSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRL 446

Query: 3332 EGPSEAHCTENGT---WSHPVPLCKPNPCPVP 3360
             G S A C  +G    WS   P+C+   CP P
Sbjct: 447  IGHSSAECILSGNTAHWSMKPPICQQIFCPNP 478



 Score =  145 bits (367), Expect = 5e-34
 Identities = 111/427 (25%), Positives = 164/427 (38%), Gaps = 53/427 (12%)

Query: 1651 GSKVNLFCDPGFQLVGNPVQY-CLNQGQWTQPLPHCERISCGVPPPLENGF-HSADDFYA 1708
            G+ +N  C PG+   G P    CL    WT     C+R SC  PP   NG  H   D   
Sbjct: 58   GTYLNYECRPGYS--GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQF 115

Query: 1709 GSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSC---------------------- 1743
             S + Y C  GY L+G S   C  +G+   W+  +P C                      
Sbjct: 116  RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175

Query: 1744 ------LDVDECAVGSDCSEHASCLNVDGSYICS---CVPPYTGDGKNCAEPIKCKAPGN 1794
                  +    C +GS   +    +     Y  S    V  ++G    C  P KC  P N
Sbjct: 176  YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKC-TPPN 234

Query: 1795 PENG---HSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPA 1851
             ENG     +  ++++   V F CQ G+ + G + + C    +W   +P C  V    P 
Sbjct: 235  VENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPD 294

Query: 1852 I--PENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSS-P 1908
            +   E    ++  F+ G +V Y C  GY L G     C     WS + P CE   C    
Sbjct: 295  VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFL 354

Query: 1909 ENINNGKYILS-GLTYLSTASYSCDTGYSLQGPSIIECTASG---IWDRAPPACHLVFCG 1964
              + NG  +    L   +   + CD G+ L+G S   C  +G   +W+ + P C    C 
Sbjct: 355  GQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCE 414

Query: 1965 EPPA-IKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGK---WSRSDQQCLAVS 2020
             PP  +   V    +    + + Y+C  G+ L G  + EC+  G    WS     C  + 
Sbjct: 415  TPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIF 474

Query: 2021 CDEPPIV 2027
            C  PP +
Sbjct: 475  CPNPPAI 481



 Score =  145 bits (367), Expect = 5e-34
 Identities = 120/427 (28%), Positives = 182/427 (42%), Gaps = 55/427 (12%)

Query: 3086 ITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHT-----Y 3140
            + Y CR GY  +  S +IC +  VW+     C+  SC +PP   N    G AH      +
Sbjct: 61   LNYECRPGYSGRPFS-IICLKNSVWTSAKDKCKRKSCRNPPDPVN----GMAHVIKDIQF 115

Query: 3141 ESEVKLRCLEGYTMDTDTDTFTCQKDGR---WFPERISCSPKKCPLPENITHILVHGDDF 3197
             S++K  C +GY +   + + TC   G    W  +   C    C LP  I +    GD  
Sbjct: 116  RSQIKYSCPKGYRL-IGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIAN----GDFT 170

Query: 3198 SVNRQ-------VSVSCAEGY----TFEGV---NISVCQLD---GTWEPPFSDESCSPVS 3240
            S++R+       V+  C  G      FE V   +I     D   G W  P + +   P  
Sbjct: 171  SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGP-APQCIIPNK 229

Query: 3241 CGKPESPEHGFVVG---SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKET 3297
            C  P + E+G +V    S ++    + ++C+PG+ ++G     CQ   +W   +  C   
Sbjct: 230  C-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV 288

Query: 3298 RCETPLEFLNGKA---DIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKP 3354
             C+ P + L+ +    D +N + G  V YSC  GY L G +  HCT  G WS   P C+ 
Sbjct: 289  -CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEV 347

Query: 3355 NPCPVPFV--IPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC---NPDETWTQTSA 3409
              C   F+  +P   +L      +   V   C EGF L+G     C     +  W  +  
Sbjct: 348  KSCD-DFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVP 406

Query: 3410 KCEKISC-GPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGT---WT-S 3464
             CE+ SC  PP  V   +        G  I YSC +G+ L G   + C+ +G    W+  
Sbjct: 407  VCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMK 466

Query: 3465 PPICRAV 3471
            PPIC+ +
Sbjct: 467  PPICQQI 473



 Score =  140 bits (353), Expect = 2e-32
 Identities = 137/507 (27%), Positives = 199/507 (39%), Gaps = 67/507 (13%)

Query: 2901 VTEGLDYGFMKEVTFHCHEGYILHGAP-KLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGF 2959
            +T+  ++     + + C  GY   G P  + C  +  W +    CK  +C  P D  +G 
Sbjct: 49   LTDDFEFPIGTYLNYECRPGY--SGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGM 106

Query: 2960 PNGFSFIH-GGHIQYQCFPGYKLHGNSSRRCLSNGS---WSGSSPSCLPCRCSTPVI--- 3012
             +    I     I+Y C  GY+L G+SS  C+ +G+   W   +P C    C  P     
Sbjct: 107  AHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIAN 166

Query: 3013 -EYGTVNGTDFDCGKAARIQCFKG------FKLLGLSEITCEAD----GQWSSGFPHCEH 3061
             ++ +++   F  G      C  G      F+L+G   I C +     G WS   P C  
Sbjct: 167  GDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCII 226

Query: 3062 TSCGSLPMIPNAF-ISETSSW--KENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCE 3118
             +  + P + N   +S+  S      V+ + C+ G+ ++G S + C     W    P C 
Sbjct: 227  PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCS 286

Query: 3119 PLSCGSPPSVANAVATGEAHTYES---EVKLRCLEGYTMDTDTDTFTCQKDGRWFPERIS 3175
             + C  PP V +A  T       S   EV   C  GY +   T    C   G W P    
Sbjct: 287  RV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGST-YLHCTPQGDWSPAAPR 344

Query: 3176 CSPKKCP-----LPENITHILVHGDDFSVNRQVSVS----CAEGYTFEGVNISVCQLDGT 3226
            C  K C      LP    H+L     F +N Q+       C EG+  +G + S C L G 
Sbjct: 345  CEVKSCDDFLGQLPNG--HVL-----FPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397

Query: 3227 ---WEPPFSDESCSPVSCGKPESPEHGFV-VGSKYTFESTIIYQCEPGYELEGNRERVC- 3281
               W    S   C   SC  P  P +G V V +     S I Y C  G+ L G+    C 
Sbjct: 398  ESLWNS--SVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECI 455

Query: 3282 --QENRQWSGGVAICKETRCETPLEFLNGK---ADIENRTTGPNVVYSC----NRG--YS 3330
                   WS    IC++  C  P   LNG+     + +   G  V Y+C    +RG  ++
Sbjct: 456  LSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFN 515

Query: 3331 LEGPSEAHCTE----NGTWSHPVPLCK 3353
            L G S    T     NG WS P P C+
Sbjct: 516  LIGESTIRRTSEPHGNGVWSSPAPRCE 542



 Score = 64.7 bits (156), Expect = 2e-09
 Identities = 59/208 (28%), Positives = 87/208 (41%), Gaps = 28/208 (13%)

Query: 374 ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428
           EL  C  + +PP +    + T  +  N + G      C PG+DL GS+ + C P G WS 
Sbjct: 281 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSP 340

Query: 429 SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484
           +   C V++C   L Q  +GH+       L      V CDEG++L+GS    C      S
Sbjct: 341 AAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFV-CDEGFQLKGSSASYCVLAGMES 399

Query: 485 QWDGPEPRCVERHCSTFQMPKD----VIISPHNCGKQPAKFGTICYVSCRQGFILSGVKE 540
            W+   P C  + C T  +P +    VI   H         G+    SC  G  L G   
Sbjct: 400 LWNSSVPVCERKSCETPPVPVNGMVHVITDIH--------VGSRINYSCTTGHRLIG-HS 450

Query: 541 MLRCTTSGK---WNVGVQAAVCKDVEAP 565
              C  SG    W+  ++  +C+ +  P
Sbjct: 451 SAECILSGNTAHWS--MKPPICQQIFCP 476



 Score = 52.8 bits (125), Expect = 6e-06
 Identities = 29/91 (31%), Positives = 50/91 (54%), Gaps = 5/91 (5%)

Query: 406 CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA 465
           C PG+     SII CL N +W+ ++  C+ ++C +   P +G ++   +++ +++    +
Sbjct: 65  CRPGYSGRPFSII-CLKNSVWTSAKDKCKRKSCRNPPDPVNG-MAHVIKDIQFRSQIKYS 122

Query: 466 CDEGYRLEGSDKLTC--QGNSQ-WDGPEPRC 493
           C +GYRL GS   TC   GN+  WD   P C
Sbjct: 123 CPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 51/195 (26%), Positives = 76/195 (38%), Gaps = 24/195 (12%)

Query: 373 CELVHCPALKPPENGYFIQNTCNN-HFNAACGVRCHPG------FDLVGSSIILCLPN-- 423
           C+ + C       NG F   +    H+ +     C+ G      F+LVG   I C     
Sbjct: 153 CDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDD 212

Query: 424 --GLWSGSESYCRVRTCPHLRQPKH--GHISCSTREMLYKTTCLVA--CDEGYRLEGSDK 477
             G+WSG    C +   P+   P +    I  S    L+    +V   C  G+ ++G   
Sbjct: 213 QVGIWSGPAPQCII---PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSH 269

Query: 478 LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKFGTICYVSCRQGFILS 536
           + CQ  ++W+   P C  R C   Q P DV+ +      K     G   + SC  G+ L 
Sbjct: 270 VKCQALNKWEPELPSC-SRVC---QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 325

Query: 537 GVKEMLRCTTSGKWN 551
           G    L CT  G W+
Sbjct: 326 G-STYLHCTPQGDWS 339



 Score = 44.7 bits (104), Expect = 0.002
 Identities = 55/230 (23%), Positives = 75/230 (32%), Gaps = 49/230 (21%)

Query: 307 CEKGYYGKGLQY-ECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGST---------S 356
           CE GY  +G  Y  CT  P G + P      + SC    D     P G           +
Sbjct: 318 CEPGYDLRGSTYLHCT--PQGDWSPAAPRCEVKSC---DDFLGQLPNGHVLFPLNLQLGA 372

Query: 357 PEDCVCREGYRASGQT-------------------CELVHCPALKPPENGYFIQNTCNNH 397
             D VC EG++  G +                   CE   C     P NG  +    + H
Sbjct: 373 KVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNG-MVHVITDIH 431

Query: 398 FNAACGVRCHPGFDLVGSSIILCLPNGL---WSGSESYCRVRTCPHLRQPKHG-HISCST 453
             +     C  G  L+G S   C+ +G    WS     C+   CP+     +G H     
Sbjct: 432 VGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPL 491

Query: 454 REMLYKTTCLVACDEG------YRLEGSDKLTC----QGNSQWDGPEPRC 493
            ++ Y       CD        + L G   +       GN  W  P PRC
Sbjct: 492 GDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541


>gi|187960042 selectin E precursor [Homo sapiens]
          Length = 610

 Score =  196 bits (497), Expect = 5e-49
 Identities = 116/433 (26%), Positives = 189/433 (43%), Gaps = 43/433 (9%)

Query: 1732 DNGSWNGVSPSCLDVDEC----AVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPI 1787
            D G WN    S   +  C       + CS H  C+    +Y C C P ++  G  C + +
Sbjct: 121  DVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFS--GLKCEQIV 178

Query: 1788 KCKAPGNPENG-----HSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYC 1842
             C A  +PE+G     H  G  ++  +  + SC  GY    +  + C+ SGEW+  IP C
Sbjct: 179  NCTALESPEHGSLVCSHPLGN-FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPAC 237

Query: 1843 KAVSCGKPAIPENGCIEEL----AFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPP 1898
              V C     P NG +E      +F + +  T+ C +G+ L G +   C ++ +W +  P
Sbjct: 238  NVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKP 297

Query: 1899 VCEPVKCSSPENINNGKYILS-----GLTYLSTASYSCDTGYSLQGPSIIECTASGIWDR 1953
             C+ V C +     NG    S       T+ S+ +++C+ G+ LQGP+ +ECT  G W +
Sbjct: 298  TCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQ 357

Query: 1954 APPACHLVFC-----GEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGK 2008
              P C    C      E   +        +F + ++  ++C++G+ L G   ++C   G+
Sbjct: 358  QIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGE 417

Query: 2009 WSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAF-----YYCSDGYSLADNSQLLCNA 2063
            W      C AV CD            AH   G+  +     + C +G+ L  ++QL C +
Sbjct: 418  WDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTS 477

Query: 2064 QGKWVPPEGQDMPRCIAHFCEK---PPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNT 2120
            QG+W     +++P C    C     P  ++ S        +   G+V  F C EG+ LN 
Sbjct: 478  QGQWT----EEVPSCQVVKCSSLAVPGKINMS-----CSGEPVFGTVCKFACPEGWTLNG 528

Query: 2121 SAKIECMRGGQWN 2133
            SA   C   G W+
Sbjct: 529  SAARTCGATGHWS 541



 Score =  185 bits (470), Expect = 6e-46
 Identities = 108/387 (27%), Positives = 171/387 (44%), Gaps = 37/387 (9%)

Query: 2715 IECDLPTAPENGFLRFTET----SMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRC 2770
            + C    +PE+G L  +      S  S+   SC  G++ +  +   C+ + +WS   P C
Sbjct: 178  VNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPAC 237

Query: 2771 EAISCKKPNPVMNGSIK----GSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEP 2826
              + C       NG ++      ++ + +T  ++C+ G+ L G +   C    NWD ++P
Sbjct: 238  NVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKP 297

Query: 2827 ICIPVDCSSPPVSANGQVR-----GDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSG 2881
             C  V C +     NG VR       E+TF+    +TC EGF+L+G     C   G W+ 
Sbjct: 298  TCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQ 357

Query: 2882 ATPDCVPVRCATPPQLANGVTEGL-----DYGFMKEVTFHCHEGYILHGAPKLTCQSDGN 2936
              P C   +C        G    L      + +     F C +G++L G+ +L C   G 
Sbjct: 358  QIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGE 417

Query: 2937 WDAEIPLCKPVNCG----PPEDL---AHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRC 2989
            WD E P C+ V C     PP+ L   AH  P G  F +     + C  G++LHG++   C
Sbjct: 418  WDNEKPTCEAVRCDAVHQPPKGLVRCAHS-PIG-EFTYKSSCAFSCEEGFELHGSTQLEC 475

Query: 2990 LSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDC------GKAARIQCFKGFKLLGLSE 3043
             S G W+   PSC   +CS+  +  G +N     C      G   +  C +G+ L G + 
Sbjct: 476  TSQGQWTEEVPSCQVVKCSSLAVP-GKIN---MSCSGEPVFGTVCKFACPEGWTLNGSAA 531

Query: 3044 ITCEADGQWSSGFPHCEHTSCGSLPMI 3070
             TC A G WS   P CE  +  ++P++
Sbjct: 532  RTCGATGHWSGLLPTCEAPTESNIPLV 558



 Score =  182 bits (463), Expect = 4e-45
 Identities = 97/365 (26%), Positives = 162/365 (44%), Gaps = 31/365 (8%)

Query: 2674 NFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTET 2733
            NF Y +  S +C+ GY       + C   G W+   P+C  +ECD  T P NGF+   + 
Sbjct: 199  NFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQN 258

Query: 2734 ----SMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGS 2789
                   +   + C+ G  L G+    C  +  W    P C+A++C+      NGS++ S
Sbjct: 259  PGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCS 318

Query: 2790 N-----YTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQV 2844
            +     +T+ S+  + C+ G++L G  +  C     W +  P+C    C++      G +
Sbjct: 319  HSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYM 378

Query: 2845 R-----GDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLAN 2899
                     + +    E++C +GF+L+G++   C   G W    P C  VRC    Q   
Sbjct: 379  NCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPK 438

Query: 2900 GVTEGL-----DYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNC----- 2949
            G+         ++ +     F C EG+ LHG+ +L C S G W  E+P C+ V C     
Sbjct: 439  GLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAV 498

Query: 2950 -GPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSC-LPCRC 3007
             G       G P     + G   ++ C  G+ L+G+++R C + G WSG  P+C  P   
Sbjct: 499  PGKINMSCSGEP-----VFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTES 553

Query: 3008 STPVI 3012
            + P++
Sbjct: 554  NIPLV 558



 Score =  178 bits (452), Expect = 7e-44
 Identities = 104/397 (26%), Positives = 163/397 (41%), Gaps = 63/397 (15%)

Query: 1652 SKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENG----FHSADDFY 1707
            S  ++ CD G+         C++ G+W+ P+P C  + C       NG    F +   F 
Sbjct: 204  SSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFP 263

Query: 1708 AGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGS 1767
              +T T+ C  G+ L+G   + CT +G+W+   P+C                        
Sbjct: 264  WNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTC------------------------ 299

Query: 1768 YICSCVPPYTGDGKNCAEPIKCKAPGNPENG-----HSSGEIYTVGAEVTFSCQEGYQLM 1822
                             + + C+A   P+NG     HS    +T  +   F+C+EG+ L 
Sbjct: 300  -----------------KAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQ 342

Query: 1823 GVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEEL-----AFTFGSKVTYRCNKGY 1877
            G  ++ C   G+W   IP C+A  C   + PE G +  L     +F +GS   + C +G+
Sbjct: 343  GPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGF 402

Query: 1878 TLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNG-----KYILSGLTYLSTASYSCD 1932
             L G K   C     W +  P CE V+C +      G        +   TY S+ ++SC+
Sbjct: 403  VLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCE 462

Query: 1933 TGYSLQGPSIIECTASGIWDRAPPACHLVFCGE--PPAIKDAVITGNNFTFRNTVTYTCK 1990
             G+ L G + +ECT+ G W    P+C +V C     P   +   +G    F     + C 
Sbjct: 463  EGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEP-VFGTVCKFACP 521

Query: 1991 EGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIV 2027
            EG+TL G     C A G WS     C A +    P+V
Sbjct: 522  EGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLV 558



 Score =  172 bits (437), Expect = 4e-42
 Identities = 112/431 (25%), Positives = 177/431 (41%), Gaps = 76/431 (17%)

Query: 1658 CDPGFQLVGNPVQYCLNQGQWTQPLPHCERI-SCGVPPPLENGF----HSADDFYAGSTV 1712
            CDPGF  +                   CE+I +C      E+G     H   +F   S+ 
Sbjct: 165  CDPGFSGL------------------KCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSC 206

Query: 1713 TYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSC 1772
            +  C+ GY       M C  +G W+   P+C  V+  AV +  +    C    GS+    
Sbjct: 207  SISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSF---- 262

Query: 1773 VPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLES 1832
                               P N                 TF C+EG++LMG   + C  S
Sbjct: 263  -------------------PWN--------------TTCTFDCEEGFELMGAQSLQCTSS 289

Query: 1833 GEWNHLIPYCKAVSCGKPAIPENG---CIEELA--FTFGSKVTYRCNKGYTLAGDKESSC 1887
            G W++  P CKAV+C     P+NG   C    A  FTF S   + C +G+ L G  +  C
Sbjct: 290  GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVEC 349

Query: 1888 LANSSWSHSPPVCEPVKCSSPENINNG-----KYILSGLTYLSTASYSCDTGYSLQGPSI 1942
                 W+   PVCE  +C++  N   G             Y S+  +SC+ G+ L+G   
Sbjct: 350  TTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKR 409

Query: 1943 IECTASGIWDRAPPACHLVFCG---EPP--AIKDAVITGNNFTFRNTVTYTCKEGYTLAG 1997
            ++C  +G WD   P C  V C    +PP   ++ A      FT++++  ++C+EG+ L G
Sbjct: 410  LQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHG 469

Query: 1998 LDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPE-TAHRLFGDIAFYYCSDGYSLADN 2056
               +EC + G+W+     C  V C    +    +   +   +FG +  + C +G++L  +
Sbjct: 470  STQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGS 529

Query: 2057 SQLLCNAQGKW 2067
            +   C A G W
Sbjct: 530  AARTCGATGHW 540



 Score =  172 bits (435), Expect = 7e-42
 Identities = 107/394 (27%), Positives = 164/394 (41%), Gaps = 28/394 (7%)

Query: 2769 RCEAI-SCKKPNPVMNGSIKGS----NYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDE 2823
            +CE I +C       +GS+  S    N++Y S+    CD GY+ +  E   C     W  
Sbjct: 173  KCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSA 232

Query: 2824 DEPICIPVDCSSPPVSANGQVR----GDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSW 2879
              P C  V+C +    ANG V        + +     + C EGF L GA+S  C ++G+W
Sbjct: 233  PIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNW 292

Query: 2880 SGATPDCVPVRCATPPQLANGVTE-----GLDYGFMKEVTFHCHEGYILHGAPKLTCQSD 2934
                P C  V C    Q  NG          ++ F     F C EG++L G  ++ C + 
Sbjct: 293  DNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQ 352

Query: 2935 GNWDAEIPLCKPVNCGPPEDLAHGFPNGF-----SFIHGGHIQYQCFPGYKLHGNSSRRC 2989
            G W  +IP+C+   C    +   G+ N       SF +G   ++ C  G+ L G+   +C
Sbjct: 353  GQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQC 412

Query: 2990 LSNGSWSGSSPSCLPCRCSTP------VIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSE 3043
               G W    P+C   RC         ++        +F    +    C +GF+L G ++
Sbjct: 413  GPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQ 472

Query: 3044 ITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKE--NVITYSCRSGYVIQGSSD 3101
            + C + GQW+   P C+   C SL  +P       S       V  ++C  G+ + GS+ 
Sbjct: 473  LECTSQGQWTEEVPSCQVVKCSSLA-VPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAA 531

Query: 3102 LICTEKGVWSQPYPVCEPLSCGSPPSVANAVATG 3135
              C   G WS   P CE  +  + P VA   A G
Sbjct: 532  RTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAG 565



 Score =  171 bits (434), Expect = 9e-42
 Identities = 119/466 (25%), Positives = 185/466 (39%), Gaps = 84/466 (18%)

Query: 2464 YTCK--PGF-----ELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHY 2516
            YTCK  PGF     E + N T L           P   ++ C  P     G FSY     
Sbjct: 161  YTCKCDPGFSGLKCEQIVNCTAL---------ESPEHGSLVCSHPL----GNFSYNS--- 204

Query: 2517 GQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVE----GADY 2572
              + + SC+RG+       + C+ +G+W    P+CN + CD+     NGFVE       +
Sbjct: 205  --SCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSF 262

Query: 2573 SYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQ 2631
             +     + C  GF++ G     C  SG W +  PTC  + C                  
Sbjct: 263  PWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCR----------------- 305

Query: 2632 GYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYEL 2691
                                    AV +    +     + +  F + +  ++TC  G+ L
Sbjct: 306  ------------------------AVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFML 341

Query: 2692 LGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETS-----MGSAVQYSCKPG 2746
             G   + C   G W    P C + +C   + PE G++    ++      GS+ ++SC+ G
Sbjct: 342  QGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQG 401

Query: 2747 HILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSN-----YTYLSTLYYEC 2801
             +L GS    C    +W    P CEA+ C   +    G ++ ++     +TY S+  + C
Sbjct: 402  FVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSC 461

Query: 2802 DPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSS--PPVSANGQVRGDEYTFQKEIEYTC 2859
            + G+ L+G+ +  C     W E+ P C  V CSS   P   N    G E  F    ++ C
Sbjct: 462  EEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSG-EPVFGTVCKFAC 520

Query: 2860 NEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGL 2905
             EG+ L G+ +R C A G WSG  P C     +  P +A     GL
Sbjct: 521  PEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGL 566



 Score =  160 bits (406), Expect = 2e-38
 Identities = 121/465 (26%), Positives = 194/465 (41%), Gaps = 48/465 (10%)

Query: 2067 WVPPEGQDMPR---CIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAK 2123
            W P E  +  +   C+  + ++   V     E  SK K A        C      NTS  
Sbjct: 97   WAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLAL-------CYTAACTNTSCS 149

Query: 2124 -------------IECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAY 2170
                          +C  G         + C  +   E  S++  +  G N+S+ +  + 
Sbjct: 150  GHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLG-NFSYNSSCSI 208

Query: 2171 SCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLE--HTTGRI-FESEV 2227
            SC++G+     +   C ++G+WS+PIP C+ V C       NGF+E     G   + +  
Sbjct: 209  SCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTC 268

Query: 2228 RYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVG---- 2283
             + C  G++ +G+    C ++ +W +E P  C  + C      QNG ++  +   G    
Sbjct: 269  TFDCEEGFELMGAQSLQCTSSGNWDNEKP-TCKAVTCRAVRQPQNGSVRCSHSPAGEFTF 327

Query: 2284 -SKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKC-----PEPPLLENQLVLKE 2337
             S   F C EG+ L G +   C   G+W ++  P C   +C     PE   + N L    
Sbjct: 328  KSSCNFTCEEGFMLQGPAQVECTTQGQWTQQI-PVCEAFQCTALSNPERGYM-NCLPSAS 385

Query: 2338 LTTEVG-VVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLC----TPPPLISFGVP 2392
             +   G    FSC++G VL+G   L+C P+ +W++  P C+ V C     PP  +     
Sbjct: 386  GSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAH 445

Query: 2393 IPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGI-I 2451
             P     + S+  +SC  GF L G++   C   G W+  +P C  V+C     +P  I +
Sbjct: 446  SPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKC-SSLAVPGKINM 504

Query: 2452 DVQGLAYLSTAL-YTCKPGFELVGNTTTLCGENGHWLGGKPTCKA 2495
               G     T   + C  G+ L G+    CG  GHW G  PTC+A
Sbjct: 505  SCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549



 Score =  155 bits (393), Expect = 5e-37
 Identities = 98/346 (28%), Positives = 145/346 (41%), Gaps = 30/346 (8%)

Query: 2849 YTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLD-- 2906
            +++      +C+ G+L     +  C+++G WS   P C  V C      ANG  E     
Sbjct: 200  FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNP 259

Query: 2907 --YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHG------ 2958
              + +    TF C EG+ L GA  L C S GNWD E P CK V C       +G      
Sbjct: 260  GSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSH 319

Query: 2959 FPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRC---STPVIEYG 3015
             P G  F       + C  G+ L G +   C + G W+   P C   +C   S P  E G
Sbjct: 320  SPAG-EFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNP--ERG 376

Query: 3016 TVN-----GTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMI 3070
             +N        F  G +    C +GF L G   + C   G+W +  P CE   C ++   
Sbjct: 377  YMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQP 436

Query: 3071 PNAFISETSS-----WKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGS- 3124
            P   +    S       ++   +SC  G+ + GS+ L CT +G W++  P C+ + C S 
Sbjct: 437  PKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSL 496

Query: 3125 -PPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRW 3169
              P   N   +GE   + +  K  C EG+T++  +   TC   G W
Sbjct: 497  AVPGKINMSCSGEP-VFGTVCKFACPEGWTLN-GSAARTCGATGHW 540



 Score =  155 bits (392), Expect = 7e-37
 Identities = 102/361 (28%), Positives = 150/361 (41%), Gaps = 26/361 (7%)

Query: 2279 NFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKEL 2338
            NF   S     C+ GY      +  C  SG+W+    P C   +C       N  V  E 
Sbjct: 199  NFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPI-PACNVVECDAVTNPANGFV--EC 255

Query: 2339 TTEVG------VVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVP 2392
                G        TF C+EG  L G   L+C  S  W++  P CK V C        G  
Sbjct: 256  FQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSV 315

Query: 2393 ----IPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPN 2448
                 P+    F S+  ++C  GF L+G +   C   G W+  +P C   +C        
Sbjct: 316  RCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPER 375

Query: 2449 GIIDVQGLA-----YLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIEC----L 2499
            G ++    A     Y S+  ++C+ GF L G+    CG  G W   KPTC+A+ C     
Sbjct: 376  GYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQ 435

Query: 2500 KPKEILNGKFS-YTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDS 2558
             PK ++    S   +  Y  +  +SC  GF L G + L C   G W  + PSC  + C S
Sbjct: 436  PPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495

Query: 2559 -PQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPTC-MPIDCGL 2615
               P +       +  +G +  ++C  G+ + G A +TC  +G WS  +PTC  P +  +
Sbjct: 496  LAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNI 555

Query: 2616 P 2616
            P
Sbjct: 556  P 556



 Score =  138 bits (348), Expect = 9e-32
 Identities = 89/371 (23%), Positives = 143/371 (38%), Gaps = 40/371 (10%)

Query: 3159 DTFTCQKD----GRWFPERISCSPKKCPLPENITHILVHG-DDFSVNRQVSVSCAEGYTF 3213
            + +TC+ D    G    + ++C+  + P  E+ + +  H   +FS N   S+SC  GY  
Sbjct: 159  NNYTCKCDPGFSGLKCEQIVNCTALESP--EHGSLVCSHPLGNFSYNSSCSISCDRGYLP 216

Query: 3214 EGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVV----GSKYTFESTIIYQCEP 3269
              +    C   G W  P    +C+ V C    +P +GFV        + + +T  + CE 
Sbjct: 217  SSMETMQCMSSGEWSAPIP--ACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEE 274

Query: 3270 GYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGP-----NVVYS 3324
            G+EL G +   C  +  W      CK   C    +  NG     +   G      +  ++
Sbjct: 275  GFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFT 334

Query: 3325 CNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALL-----SEKEFYVDQN 3379
            C  G+ L+GP++  CT  G W+  +P+C+   C      PE   +     +   F    +
Sbjct: 335  CEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQC-TALSNPERGYMNCLPSASGSFRYGSS 393

Query: 3380 VSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVH-----YQY 3434
                C +GF+L+G   + C P   W      CE + C         + R  H     + Y
Sbjct: 394  CEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTY 453

Query: 3435 GDMITYSCYSGYMLEGFLRSVCLENGTWTSP-PICRAV----------CRFPCQNGGICQ 3483
                 +SC  G+ L G  +  C   G WT   P C+ V              C    +  
Sbjct: 454  KSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFG 513

Query: 3484 RPNACSCPEGW 3494
                 +CPEGW
Sbjct: 514  TVCKFACPEGW 524



 Score =  131 bits (329), Expect = 1e-29
 Identities = 80/292 (27%), Positives = 131/292 (44%), Gaps = 18/292 (6%)

Query: 292 GSCKCGTHTGHFECICEKGYYGKGLQY--ECTACPSGTY------KPEGSPGGISSCIPC 343
           G  +C     ++ C C+ G+ G   +    CTA  S  +       P G+    SSC   
Sbjct: 150 GHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSIS 209

Query: 344 PDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYF--IQNTCNNHFNAA 401
            D  +   P S     C+    + A    C +V C A+  P NG+    QN  +  +N  
Sbjct: 210 CDRGYL--PSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTT 267

Query: 402 CGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCS---TREMLY 458
           C   C  GF+L+G+  + C  +G W   +  C+  TC  +RQP++G + CS     E  +
Sbjct: 268 CTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTF 327

Query: 459 KTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQP 518
           K++C   C+EG+ L+G  ++ C    QW    P C    C+    P+   ++        
Sbjct: 328 KSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGS 387

Query: 519 AKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCP 570
            ++G+ C  SC QGF+L G K  L+C  +G+W+   +   C+ V    ++ P
Sbjct: 388 FRYGSSCEFSCEQGFVLKGSKR-LQCGPTGEWD--NEKPTCEAVRCDAVHQP 436



 Score =  130 bits (326), Expect = 3e-29
 Identities = 91/388 (23%), Positives = 153/388 (39%), Gaps = 24/388 (6%)

Query: 2019 VSCDEPPIVDHASPETAHRL----FGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQD 2074
            V+C      +H S   +H L    +       C  GY  +    + C + G+W  P    
Sbjct: 178  VNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAP---- 233

Query: 2075 MPRCIAHFCEKPPSVSYSILESVSK-AKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWN 2133
            +P C    C+   + +   +E       F   +  +F C EGF L  +  ++C   G W+
Sbjct: 234  IPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWD 293

Query: 2134 ---PSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATG 2190
               P+  ++ C  VR  +  S+   ++    ++F +   ++C +GF ++G  +  C   G
Sbjct: 294  NEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG 353

Query: 2191 QWSSPIPTCHPVSCGEPPKVENGF---LEHTTGRI-FESEVRYQCNPGYKSVGSPVFVCQ 2246
            QW+  IP C    C      E G+   L   +G   + S   + C  G+   GS    C 
Sbjct: 354  QWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCG 413

Query: 2247 ANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVG-----SKVQFFCNEGYELVGDSS 2301
                W +E P  C  + C        G ++  +  +G     S   F C EG+EL G + 
Sbjct: 414  PTGEWDNEKPT-CEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQ 472

Query: 2302 WTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVT-FSCKEGHVLQGPSV 2360
              C   G+W ++  P C   KC    +     +        G V  F+C EG  L G + 
Sbjct: 473  LECTSQGQWTEEV-PSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAA 531

Query: 2361 LKCLPSQQWNDSFPVCKIVLCTPPPLIS 2388
              C  +  W+   P C+    +  PL++
Sbjct: 532  RTCGATGHWSGLLPTCEAPTESNIPLVA 559



 Score =  127 bits (320), Expect = 2e-28
 Identities = 85/366 (23%), Positives = 147/366 (40%), Gaps = 30/366 (8%)

Query: 3021 DFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFI---SE 3077
            +F    +  I C +G+    +  + C + G+WS+  P C    C ++    N F+     
Sbjct: 199  NFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQN 258

Query: 3078 TSSWKEN-VITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGS-----PPSVANA 3131
              S+  N   T+ C  G+ + G+  L CT  G W    P C+ ++C +       SV  +
Sbjct: 259  PGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCS 318

Query: 3132 VATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPEN----- 3186
             +     T++S     C EG+ +        C   G+W  +   C   +C    N     
Sbjct: 319  HSPAGEFTFKSSCNFTCEEGFMLQGPAQV-ECTTQGQWTQQIPVCEAFQCTALSNPERGY 377

Query: 3187 ITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPES 3246
            +  +      F        SC +G+  +G     C   G W+      +C  V C     
Sbjct: 378  MNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN--EKPTCEAVRCDAVHQ 435

Query: 3247 PEHGFV------VGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCE 3300
            P  G V      +G ++T++S+  + CE G+EL G+ +  C    QW+  V  C+  +C 
Sbjct: 436  PPKGLVRCAHSPIG-EFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCS 494

Query: 3301 TPLEFLNGKADIE---NRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCK-PNP 3356
            +    + GK ++        G    ++C  G++L G +   C   G WS  +P C+ P  
Sbjct: 495  SLA--VPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTE 552

Query: 3357 CPVPFV 3362
              +P V
Sbjct: 553  SNIPLV 558



 Score =  123 bits (308), Expect = 4e-27
 Identities = 79/287 (27%), Positives = 113/287 (39%), Gaps = 57/287 (19%)

Query: 1636 GSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPP 1695
            GSV    + + +    S  N  C+ GF L G     C  QGQWTQ +P CE   C     
Sbjct: 313  GSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSN 372

Query: 1696 LENGF-----HSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECA 1750
             E G+      ++  F  GS+  + C  G+ L G  R+ C   G W+   P+C       
Sbjct: 373  PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTC------- 425

Query: 1751 VGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENG-----HSSGEIY 1805
                                              E ++C A   P  G     HS    +
Sbjct: 426  ----------------------------------EAVRCDAVHQPPKGLVRCAHSPIGEF 451

Query: 1806 TVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPEN---GCIEELA 1862
            T  +   FSC+EG++L G T++ C   G+W   +P C+ V C   A+P      C  E  
Sbjct: 452  TYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPV 511

Query: 1863 FTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCE-PVKCSSP 1908
            F  G+   + C +G+TL G    +C A   WS   P CE P + + P
Sbjct: 512  F--GTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIP 556



 Score =  120 bits (302), Expect = 2e-26
 Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 25/353 (7%)

Query: 3139 TYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILV----HG 3194
            +Y S   + C  GY + +  +T  C   G W     +C+  +C    N  +  V    + 
Sbjct: 201  SYNSSCSISCDRGY-LPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNP 259

Query: 3195 DDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVG 3254
              F  N   +  C EG+   G     C   G W+      +C  V+C     P++G V  
Sbjct: 260  GSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDN--EKPTCKAVTCRAVRQPQNGSVRC 317

Query: 3255 S-----KYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGK 3309
            S     ++TF+S+  + CE G+ L+G  +  C    QW+  + +C+  +C        G 
Sbjct: 318  SHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGY 377

Query: 3310 ADIENRTTGP-----NVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIP 3364
             +     +G      +  +SC +G+ L+G     C   G W +  P C+   C      P
Sbjct: 378  MNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPP 437

Query: 3365 ENALLSEK----EFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPA 3420
            +  +        EF    + +  C EGF L G   + C     WT+    C+ + C   A
Sbjct: 438  KGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLA 497

Query: 3421 HVENAIARGVHYQ--YGDMITYSCYSGYMLEGFLRSVCLENGTWTS-PPICRA 3470
             V   I      +  +G +  ++C  G+ L G     C   G W+   P C A
Sbjct: 498  -VPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549



 Score =  117 bits (294), Expect = 2e-25
 Identities = 78/343 (22%), Positives = 126/343 (36%), Gaps = 22/343 (6%)

Query: 3089 SCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVA----TGEAHTYESEV 3144
            SC  GY+      + C   G WS P P C  + C +  + AN          +  + +  
Sbjct: 209  SCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTC 268

Query: 3145 KLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPL---PENITHILVHGD--DFSV 3199
               C EG+ +     +  C   G W  E+ +C    C     P+N +    H    +F+ 
Sbjct: 269  TFDCEEGFEL-MGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTF 327

Query: 3200 NRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFV-----VG 3254
                + +C EG+  +G     C   G W        C    C    +PE G++       
Sbjct: 328  KSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIP--VCEAFQCTALSNPERGYMNCLPSAS 385

Query: 3255 SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNG-----K 3309
              + + S+  + CE G+ L+G++   C    +W      C+  RC+   +   G      
Sbjct: 386  GSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAH 445

Query: 3310 ADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALL 3369
            + I   T   +  +SC  G+ L G ++  CT  G W+  VP C+   C    V  +  + 
Sbjct: 446  SPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMS 505

Query: 3370 SEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCE 3412
               E          C EG+ L G    TC     W+     CE
Sbjct: 506  CSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCE 548



 Score =  115 bits (289), Expect = 6e-25
 Identities = 91/340 (26%), Positives = 140/340 (41%), Gaps = 44/340 (12%)

Query: 244 YLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHTGHF 303
           YL  S E  + ++       +P+ + ++ D V  +   +   +C    GS    T T  F
Sbjct: 214 YLPSSMETMQCMSSGEWSAPIPACNVVECDAV--TNPANGFVECFQNPGSFPWNT-TCTF 270

Query: 304 ECICEKGYYGKGLQ-YECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPE---- 358
           +C  E+G+   G Q  +CT+  SG +  E       +C       + S   S SP     
Sbjct: 271 DC--EEGFELMGAQSLQCTS--SGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT 326

Query: 359 -----DCVCREGYRASGQT----------------CELVHCPALKPPENGYFI---QNTC 394
                +  C EG+   G                  CE   C AL  PE GY       + 
Sbjct: 327 FKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASG 386

Query: 395 NNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTR 454
           +  + ++C   C  GF L GS  + C P G W   +  C    C  + QP  G + C+  
Sbjct: 387 SFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHS 446

Query: 455 ---EMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
              E  YK++C  +C+EG+ L GS +L C    QW    P C    CS+  +P  + +S 
Sbjct: 447 PIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMS- 505

Query: 512 HNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
             C  +P  FGT+C  +C +G+ L+G      C  +G W+
Sbjct: 506 --CSGEPV-FGTVCKFACPEGWTLNG-SAARTCGATGHWS 541



 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 64/239 (26%), Positives = 92/239 (38%), Gaps = 41/239 (17%)

Query: 292 GSCKC-----GTHTGHFEC--ICEKGYYGKG-LQYECTACPSGTYKPEGSPGGISSCIPC 343
           GS +C     G  T    C   CE+G+  +G  Q ECT     T +         + +  
Sbjct: 313 GSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSN 372

Query: 344 PDENHTSPPGSTSPE-------DCVCREGYRASGQ----------------TCELVHCPA 380
           P+  + +   S S         +  C +G+   G                 TCE V C A
Sbjct: 373 PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDA 432

Query: 381 LKPPENGYFIQNTCNNH------FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCR 434
           +  P  G      C +       + ++C   C  GF+L GS+ + C   G W+     C+
Sbjct: 433 VHQPPKGLV---RCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQ 489

Query: 435 VRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRC 493
           V  C  L  P   ++SCS  E ++ T C  AC EG+ L GS   TC     W G  P C
Sbjct: 490 VVKCSSLAVPGKINMSCSG-EPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTC 547



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 44/190 (23%), Positives = 70/190 (36%), Gaps = 37/190 (19%)

Query: 1273 CSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVN-ECQSNPCLNNAVCEDQVGGFLC 1331
            C+++ C   G CV+ +  Y C C  GF GL CE  VN     +P   + VC   +G F  
Sbjct: 143  CTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNF-- 200

Query: 1332 KCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQ--S 1389
                         + +   S  C  G        + +C+ +  ++      N+ EC   +
Sbjct: 201  -------------SYNSSCSISCDRG-YLPSSMETMQCMSSGEWSAPIPACNVVECDAVT 246

Query: 1390 NPCRNQATCVDELNSY------SCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDG 1443
            NP      C     S+      +  C+ GF     ++ Q T        SG +     D 
Sbjct: 247  NPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS-------SGNW-----DN 294

Query: 1444 MLPSLHALTC 1453
              P+  A+TC
Sbjct: 295  EKPTCKAVTC 304



 Score = 43.1 bits (100), Expect = 0.005
 Identities = 39/137 (28%), Positives = 57/137 (41%), Gaps = 22/137 (16%)

Query: 988  CRPGSVLRGRMCVNC-PLGTYYNLEHFTCESCRIGS-YQDEEGQLECKLCPSGMYTEYIH 1045
            C  G VL+G   + C P G + N E  TCE+ R  + +Q  +G + C   P G +T    
Sbjct: 398  CEQGFVLKGSKRLQCGPTGEWDN-EKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYK-- 454

Query: 1046 SRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSCPENTSTVKRGAVNISA 1105
                S C   C++G +   G    E    G +  +  S   + C   +S    G +N+S 
Sbjct: 455  ----SSCAFSCEEG-FELHGSTQLECTSQGQWTEEVPSCQVVKC---SSLAVPGKINMSC 506

Query: 1106 CGVP---------CPEG 1113
             G P         CPEG
Sbjct: 507  SGEPVFGTVCKFACPEG 523



 Score = 40.0 bits (92), Expect = 0.041
 Identities = 28/88 (31%), Positives = 35/88 (39%), Gaps = 11/88 (12%)

Query: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNG--VCKDLVGEF- 1253
            C    C   G C +    Y C C  G++GLKCE  I  C+ L    +G  VC   +G F 
Sbjct: 143  CTNTSCSGHGECVETINNYTCKCDPGFSGLKCE-QIVNCTALESPEHGSLVCSHPLGNFS 201

Query: 1254 -----ICECPSGYTGQRCEENINECSSS 1276
                    C  GY     E    +C SS
Sbjct: 202  YNSSCSISCDRGYLPSSME--TMQCMSS 227



 Score = 39.3 bits (90), Expect = 0.071
 Identities = 34/152 (22%), Positives = 60/152 (39%), Gaps = 24/152 (15%)

Query: 1235 CSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSS--SPCLNKGICVDGVAGY- 1291
            C+   C  +G C + +  + C+C  G++G +CE+ +N C++  SP     +C   +  + 
Sbjct: 143  CTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVN-CTALESPEHGSLVCSHPLGNFS 201

Query: 1292 -----RCTCVKGFVGLHCETEVNECQSN-------PCLNNAVCE---DQVGGFL-CKCPP 1335
                   +C +G+  L    E  +C S+       P  N   C+   +   GF+ C   P
Sbjct: 202  YNSSCSISCDRGY--LPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNP 259

Query: 1336 GFL--GTRCGKNVDECLSQPCKNGATCKDGAN 1365
            G     T C  + +E           C    N
Sbjct: 260  GSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN 291



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 42/165 (25%), Positives = 55/165 (33%), Gaps = 39/165 (23%)

Query: 304 ECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGS--------- 354
           E  CE+G+  KG +      P+G +  E        C    D  H  P G          
Sbjct: 395 EFSCEQGFVLKGSK-RLQCGPTGEWDNEKPTCEAVRC----DAVHQPPKGLVRCAHSPIG 449

Query: 355 --TSPEDCV--CREGYRASGQT----------------CELVHCPALKPPENGYFIQNTC 394
             T    C   C EG+   G T                C++V C +L  P     I  +C
Sbjct: 450 EFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGK---INMSC 506

Query: 395 NNH--FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRT 437
           +    F   C   C  G+ L GS+   C   G WSG    C   T
Sbjct: 507 SGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPT 551


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.452 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 175,223,206
Number of Sequences: 37866
Number of extensions: 9726704
Number of successful extensions: 50073
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 297
Number of HSP's successfully gapped in prelim test: 319
Number of HSP's that attempted gapping in prelim test: 20509
Number of HSP's gapped (non-prelim): 12201
length of query: 3571
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3449
effective length of database: 13,627,866
effective search space: 47002509834
effective search space used: 47002509834
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 72 (32.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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