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Search of human proteins with 148727341
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148727341 serine/threonine kinase receptor associated
protein [Homo sapiens]
(350 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148727341 serine/threonine kinase receptor associated protein... 719 0.0
gi|239753142 PREDICTED: similar to unr-interacting protein [Homo... 620 e-178
gi|239747708 PREDICTED: similar to unr-interacting protein [Homo... 620 e-178
gi|113412837 PREDICTED: similar to unr-interacting protein [Homo... 615 e-176
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 100 2e-21
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 100 2e-21
gi|4503513 eukaryotic translation initiation factor 3, subunit 2... 99 6e-21
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 97 2e-20
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 97 2e-20
gi|32189425 WD repeat domain 69 [Homo sapiens] 97 3e-20
gi|26665869 WD repeat domain 51B [Homo sapiens] 94 2e-19
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 93 3e-19
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 93 3e-19
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 93 3e-19
gi|113865883 WD repeat domain 38 [Homo sapiens] 92 9e-19
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 91 1e-18
gi|16554629 WD repeat domain 5 [Homo sapiens] 86 6e-17
gi|16554627 WD repeat domain 5 [Homo sapiens] 86 6e-17
gi|21071067 TBP-associated factor 5 [Homo sapiens] 85 1e-16
gi|23199987 WD repeat domain 5B [Homo sapiens] 83 4e-16
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 80 3e-15
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 79 5e-15
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 78 1e-14
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 78 1e-14
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 73 3e-13
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 73 3e-13
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 72 6e-13
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 72 6e-13
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 72 6e-13
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 72 1e-12
>gi|148727341 serine/threonine kinase receptor associated protein
[Homo sapiens]
Length = 350
Score = 719 bits (1856), Expect = 0.0
Identities = 350/350 (100%), Positives = 350/350 (100%)
Query: 1 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKG 60
MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKG
Sbjct: 1 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKG 60
Query: 61 AVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQ 120
AVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQ
Sbjct: 61 AVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQ 120
Query: 121 DKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSL 180
DKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSL
Sbjct: 121 DKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSL 180
Query: 181 NFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVA 240
NFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVA
Sbjct: 181 NFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVA 240
Query: 241 GGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTY 300
GGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTY
Sbjct: 241 GGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTY 300
Query: 301 GLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA 350
GLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA
Sbjct: 301 GLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA 350
>gi|239753142 PREDICTED: similar to unr-interacting protein [Homo
sapiens]
Length = 347
Score = 620 bits (1599), Expect = e-178
Identities = 312/350 (89%), Positives = 322/350 (92%), Gaps = 3/350 (0%)
Query: 1 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKG 60
MAMRQT LT GHT P+VDLAFSGIT YGYFL SA KDGKPMLRQGDTGDWIGTF GHKG
Sbjct: 1 MAMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKG 60
Query: 61 AVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQ 120
AVWGATLN ATKAATAAADFTAKVWDAV GDELMTLAHK+IVKTV F QDSNYLLT GQ
Sbjct: 61 AVWGATLN--ATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQ 118
Query: 121 DKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSL 180
DKLLR+YDLNKP+A PKEISGHTSGIKK LWCSEDKQILSADDKT RLWDHATMTEVKSL
Sbjct: 119 DKLLRMYDLNKPKARPKEISGHTSGIKKGLWCSEDKQILSADDKTARLWDHATMTEVKSL 178
Query: 181 NFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVA 240
NFNMSVSS +YIPEGEILVITYG SIAFHSAVSLDPI SFEAPATINSASLHPEKEFLVA
Sbjct: 179 NFNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLVA 238
Query: 241 GGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTY 300
GGEDFKLYKY +N GEE ESYKG+FGPIHCVRFS DGELYASGSEDGTLRL QTVVGKTY
Sbjct: 239 GGEDFKLYKY-FNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTY 297
Query: 301 GLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA 350
GLWKCVLPEE+SGELAKPKIGFPETTEEELEEI SE+SDCI+ S PDVKA
Sbjct: 298 GLWKCVLPEEESGELAKPKIGFPETTEEELEEIVSEDSDCIYSSTPDVKA 347
>gi|239747708 PREDICTED: similar to unr-interacting protein [Homo
sapiens]
Length = 347
Score = 620 bits (1599), Expect = e-178
Identities = 312/350 (89%), Positives = 322/350 (92%), Gaps = 3/350 (0%)
Query: 1 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKG 60
MAMRQT LT GHT P+VDLAFSGIT YGYFL SA KDGKPMLRQGDTGDWIGTF GHKG
Sbjct: 1 MAMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKG 60
Query: 61 AVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQ 120
AVWGATLN ATKAATAAADFTAKVWDAV GDELMTLAHK+IVKTV F QDSNYLLT GQ
Sbjct: 61 AVWGATLN--ATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQ 118
Query: 121 DKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSL 180
DKLLR+YDLNKP+A PKEISGHTSGIKK LWCSEDKQILSADDKT RLWDHATMTEVKSL
Sbjct: 119 DKLLRMYDLNKPKARPKEISGHTSGIKKGLWCSEDKQILSADDKTARLWDHATMTEVKSL 178
Query: 181 NFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVA 240
NFNMSVSS +YIPEGEILVITYG SIAFHSAVSLDPI SFEAPATINSASLHPEKEFLVA
Sbjct: 179 NFNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLVA 238
Query: 241 GGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTY 300
GGEDFKLYKY +N GEE ESYKG+FGPIHCVRFS DGELYASGSEDGTLRL QTVVGKTY
Sbjct: 239 GGEDFKLYKY-FNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTY 297
Query: 301 GLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA 350
GLWKCVLPEE+SGELAKPKIGFPETTEEELEEI SE+SDCI+ S PDVKA
Sbjct: 298 GLWKCVLPEEESGELAKPKIGFPETTEEELEEIVSEDSDCIYSSTPDVKA 347
>gi|113412837 PREDICTED: similar to unr-interacting protein [Homo
sapiens]
Length = 348
Score = 615 bits (1586), Expect = e-176
Identities = 312/351 (88%), Positives = 322/351 (91%), Gaps = 4/351 (1%)
Query: 1 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKG 60
MAMRQT LT GHT P+VDLAFSGIT YGYFL SA KDGKPMLRQGDTGDWIGTF GHKG
Sbjct: 1 MAMRQTLLTYFGHTWPMVDLAFSGITTYGYFLTSAYKDGKPMLRQGDTGDWIGTFWGHKG 60
Query: 61 AVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQ 120
AVWGATLN ATKAATAAADFTAKVWDAV GDELMTLAHK+IVKTV F QDSNYLLT GQ
Sbjct: 61 AVWGATLN--ATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYFMQDSNYLLTKGQ 118
Query: 121 DKLLRIYDLNKPEAEPKEISGHTSGIKKAL-WCSEDKQILSADDKTVRLWDHATMTEVKS 179
DKLLR+YDLNKP+A PKEISGHTSGIKK L WCSEDKQILSADDKT RLWDHATMTEVKS
Sbjct: 119 DKLLRMYDLNKPKARPKEISGHTSGIKKRLLWCSEDKQILSADDKTARLWDHATMTEVKS 178
Query: 180 LNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLV 239
LNFNMSVSS +YIPEGEILVITYG SIAFHSAVSLDPI SFEAPATINSASLHPEKEFLV
Sbjct: 179 LNFNMSVSSTKYIPEGEILVITYGLSIAFHSAVSLDPITSFEAPATINSASLHPEKEFLV 238
Query: 240 AGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKT 299
AGGEDFKLYKY +N GEE ESYKG+FGPIHCVRFS DGELYASGSEDGTLRL QTVVGKT
Sbjct: 239 AGGEDFKLYKY-FNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKT 297
Query: 300 YGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA 350
YGLWKCVLPEE+SGELAKPKIGFPETTEEELEEI SE+SDCI+ S PDVKA
Sbjct: 298 YGLWKCVLPEEESGELAKPKIGFPETTEEELEEIVSEDSDCIYSSTPDVKA 348
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 100 bits (249), Expect = 2e-21
Identities = 79/303 (26%), Positives = 134/303 (44%), Gaps = 26/303 (8%)
Query: 13 HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72
HT V FS G + S D + + +TG+ + H+ V + D
Sbjct: 614 HTDAVYHACFS---EDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
Query: 73 KAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLL--TGGQDKLLRIYDL 129
AT + D K+W++++G+ + T H V FT S++LL TG D L+++DL
Sbjct: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 730
Query: 130 NKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSLNFNMSVSS 188
N+ E + GHT+ + + +DK + S D T++LWD + E KS+N +
Sbjct: 731 NQKECR-NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789
Query: 189 MEYIPE---------------GEILVITYGRSIAF--HSAVSLDPIKSFEAPATINSASL 231
+E E I+V + F H++ L I + +TI
Sbjct: 790 LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH-STIQYCDF 848
Query: 232 HPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRL 291
P+ V + + ++ +S ++ +GH +H V FSPDG + + S+D T+RL
Sbjct: 849 SPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 908
Query: 292 WQT 294
W+T
Sbjct: 909 WET 911
Score = 48.9 bits (115), Expect = 7e-06
Identities = 35/106 (33%), Positives = 55/106 (51%), Gaps = 7/106 (6%)
Query: 32 LISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSG 91
L+S DG + TG+ F+ H+G V ++ DATK ++ +AD TAK+W S
Sbjct: 1058 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW---SF 1114
Query: 92 DELMTL----AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPE 133
D L+ L H V+ F+ DS L TG + +RI++++ E
Sbjct: 1115 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1160
Score = 48.1 bits (113), Expect = 1e-05
Identities = 57/330 (17%), Positives = 116/330 (35%), Gaps = 49/330 (14%)
Query: 13 HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72
HT + + +P + + A L D+ + GH V G + D +
Sbjct: 836 HTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGS 895
Query: 73 KAATAAADFTAKVWDA------------------VSGDELMTLAHKHIVKT--------- 105
T++ D T ++W+ +E+M LA HI +
Sbjct: 896 SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 955
Query: 106 VDFTQDSN-----------YLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALW--- 151
+D+ ++ Y+ G ++ + I +L KK +W
Sbjct: 956 IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH-----KKTVWHIQ 1010
Query: 152 --CSEDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFH 209
E I S+DD +++W+ + +V + +L ++ ++
Sbjct: 1011 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVW 1070
Query: 210 SAVSLDPIKSFEA-PATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPI 268
+ ++ + K F T+ S + + + D + ++ L +GH G +
Sbjct: 1071 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCV 1130
Query: 269 HCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
C FS D L A+G ++G +R+W G+
Sbjct: 1131 RCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1160
Score = 37.4 bits (85), Expect = 0.020
Identities = 61/379 (16%), Positives = 128/379 (33%), Gaps = 100/379 (26%)
Query: 54 TFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKH------------ 101
T GH +V + D A+ +AD T K+WDA S +E ++ K
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797
Query: 102 --IVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKA---------- 149
IVK ++ D ++ ++K+ ++D++ + +GH S I+
Sbjct: 798 EVIVKCCSWSADGARIMVAAKNKIF-LFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAV 856
Query: 150 ---------LWCSEDKQ------------------------ILSADDKTVRLWDHATMTE 176
LW ++ + + S+DD+T+RLW+ + +
Sbjct: 857 VALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCK 916
Query: 177 VKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKE 236
++ V + E E++V+ + A ++ L P +
Sbjct: 917 NSAVMLKQEVDVV--FQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQ 974
Query: 237 FLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED---------- 286
++ G E+ + + + +S H + ++F+ D + S S+D
Sbjct: 975 YIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL 1034
Query: 287 ------------------------------GTLRLWQTVVGKTYGLWKCVLPEEDSGELA 316
GT+++W + G + C S +++
Sbjct: 1035 DKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1094
Query: 317 KPKIGFPETTEEELEEIAS 335
F T+ ++ +I S
Sbjct: 1095 HDATKFSSTSADKTAKIWS 1113
Score = 35.8 bits (81), Expect = 0.059
Identities = 17/57 (29%), Positives = 28/57 (49%)
Query: 242 GEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
G D L + +GE+L K H + C FS D A+ S D +++W ++ G+
Sbjct: 634 GADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGE 690
Score = 35.0 bits (79), Expect = 0.10
Identities = 43/249 (17%), Positives = 91/249 (36%), Gaps = 14/249 (5%)
Query: 58 HKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLT 117
HK VW D +++ D +VW+ + H+ VK ++S LL+
Sbjct: 1002 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLS 1060
Query: 118 GGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEV 177
D ++++++ E + + + + K ++ DKT ++W + +
Sbjct: 1061 WSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL 1120
Query: 178 KSLN-----FNMSVSSMEYI------PEGEILVITYGRSIAFHSAVSLDPIKSFEAPATI 226
L S S++ GEI + H L + +
Sbjct: 1121 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1180
Query: 227 NSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED 286
P+ + L++ G K ++ +GE +++ + + + SPD + Y +
Sbjct: 1181 TDLCFSPDGKMLISAGGYIKW--WNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNL 1238
Query: 287 GTLRLWQTV 295
G L + QT+
Sbjct: 1239 GILYILQTL 1247
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 100 bits (249), Expect = 2e-21
Identities = 79/303 (26%), Positives = 134/303 (44%), Gaps = 26/303 (8%)
Query: 13 HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72
HT V FS G + S D + + +TG+ + H+ V + D
Sbjct: 603 HTDAVYHACFS---EDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
Query: 73 KAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLL--TGGQDKLLRIYDL 129
AT + D K+W++++G+ + T H V FT S++LL TG D L+++DL
Sbjct: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719
Query: 130 NKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSLNFNMSVSS 188
N+ E + GHT+ + + +DK + S D T++LWD + E KS+N +
Sbjct: 720 NQKECR-NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
Query: 189 MEYIPE---------------GEILVITYGRSIAF--HSAVSLDPIKSFEAPATINSASL 231
+E E I+V + F H++ L I + +TI
Sbjct: 779 LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH-STIQYCDF 837
Query: 232 HPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRL 291
P+ V + + ++ +S ++ +GH +H V FSPDG + + S+D T+RL
Sbjct: 838 SPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 897
Query: 292 WQT 294
W+T
Sbjct: 898 WET 900
Score = 48.9 bits (115), Expect = 7e-06
Identities = 35/106 (33%), Positives = 55/106 (51%), Gaps = 7/106 (6%)
Query: 32 LISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSG 91
L+S DG + TG+ F+ H+G V ++ DATK ++ +AD TAK+W S
Sbjct: 1047 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW---SF 1103
Query: 92 DELMTL----AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPE 133
D L+ L H V+ F+ DS L TG + +RI++++ E
Sbjct: 1104 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1149
Score = 48.1 bits (113), Expect = 1e-05
Identities = 57/330 (17%), Positives = 116/330 (35%), Gaps = 49/330 (14%)
Query: 13 HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72
HT + + +P + + A L D+ + GH V G + D +
Sbjct: 825 HTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGS 884
Query: 73 KAATAAADFTAKVWDA------------------VSGDELMTLAHKHIVKT--------- 105
T++ D T ++W+ +E+M LA HI +
Sbjct: 885 SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 944
Query: 106 VDFTQDSN-----------YLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALW--- 151
+D+ ++ Y+ G ++ + I +L KK +W
Sbjct: 945 IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH-----KKTVWHIQ 999
Query: 152 --CSEDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFH 209
E I S+DD +++W+ + +V + +L ++ ++
Sbjct: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVW 1059
Query: 210 SAVSLDPIKSFEA-PATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPI 268
+ ++ + K F T+ S + + + D + ++ L +GH G +
Sbjct: 1060 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCV 1119
Query: 269 HCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
C FS D L A+G ++G +R+W G+
Sbjct: 1120 RCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1149
Score = 37.4 bits (85), Expect = 0.020
Identities = 61/379 (16%), Positives = 128/379 (33%), Gaps = 100/379 (26%)
Query: 54 TFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKH------------ 101
T GH +V + D A+ +AD T K+WDA S +E ++ K
Sbjct: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
Query: 102 --IVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKA---------- 149
IVK ++ D ++ ++K+ ++D++ + +GH S I+
Sbjct: 787 EVIVKCCSWSADGARIMVAAKNKIF-LFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAV 845
Query: 150 ---------LWCSEDKQ------------------------ILSADDKTVRLWDHATMTE 176
LW ++ + + S+DD+T+RLW+ + +
Sbjct: 846 VALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCK 905
Query: 177 VKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKE 236
++ V + E E++V+ + A ++ L P +
Sbjct: 906 NSAVMLKQEVDVV--FQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQ 963
Query: 237 FLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED---------- 286
++ G E+ + + + +S H + ++F+ D + S S+D
Sbjct: 964 YIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL 1023
Query: 287 ------------------------------GTLRLWQTVVGKTYGLWKCVLPEEDSGELA 316
GT+++W + G + C S +++
Sbjct: 1024 DKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1083
Query: 317 KPKIGFPETTEEELEEIAS 335
F T+ ++ +I S
Sbjct: 1084 HDATKFSSTSADKTAKIWS 1102
Score = 35.8 bits (81), Expect = 0.059
Identities = 17/57 (29%), Positives = 28/57 (49%)
Query: 242 GEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
G D L + +GE+L K H + C FS D A+ S D +++W ++ G+
Sbjct: 623 GADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGE 679
Score = 35.0 bits (79), Expect = 0.10
Identities = 43/249 (17%), Positives = 91/249 (36%), Gaps = 14/249 (5%)
Query: 58 HKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLT 117
HK VW D +++ D +VW+ + H+ VK ++S LL+
Sbjct: 991 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLS 1049
Query: 118 GGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEV 177
D ++++++ E + + + + K ++ DKT ++W + +
Sbjct: 1050 WSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL 1109
Query: 178 KSLN-----FNMSVSSMEYI------PEGEILVITYGRSIAFHSAVSLDPIKSFEAPATI 226
L S S++ GEI + H L + +
Sbjct: 1110 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1169
Query: 227 NSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED 286
P+ + L++ G K ++ +GE +++ + + + SPD + Y +
Sbjct: 1170 TDLCFSPDGKMLISAGGYIKW--WNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNL 1227
Query: 287 GTLRLWQTV 295
G L + QT+
Sbjct: 1228 GILYILQTL 1236
>gi|4503513 eukaryotic translation initiation factor 3, subunit 2
beta, 36kDa [Homo sapiens]
Length = 325
Score = 99.0 bits (245), Expect = 6e-21
Identities = 79/322 (24%), Positives = 134/322 (41%), Gaps = 50/322 (15%)
Query: 7 PLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGAT 66
P+ GH R + + ++ G L + KD + G+ +GT++GH GAVW
Sbjct: 3 PILLQGHERSITQIKYNR---EGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVD 59
Query: 67 LNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTG-----GQD 121
+ D T +AD + ++WD +G +L L V+T F N ++ G
Sbjct: 60 ADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQ 119
Query: 122 KLLRIYDLNKPEA----EP-KEISGHTSGIKKALWCSEDKQILSADDK------------ 164
+ +DL P EP +I + S I A+W + I++ +
Sbjct: 120 CFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGE 179
Query: 165 -TVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAP 223
V + +H+ L+ +M++ + + + + +L+ K+F
Sbjct: 180 VLVNVKEHSRQINDIQLSRDMTM----------FVTASKDNTAKLFDSTTLEHQKTFRTE 229
Query: 224 ATINSASLHPEKEFLVAGGED--------------FKLYKYDYNSGEELESYKGHFGPIH 269
+NSA+L P + +V GG F+ + EE KGHFGPI+
Sbjct: 230 RPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPIN 289
Query: 270 CVRFSPDGELYASGSEDGTLRL 291
V F PDG+ Y+SG EDG +R+
Sbjct: 290 SVAFHPDGKSYSSGGEDGYVRI 311
Score = 62.4 bits (150), Expect = 6e-10
Identities = 51/220 (23%), Positives = 99/220 (45%), Gaps = 25/220 (11%)
Query: 94 LMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRI-YDLNKPEAEPKEISGHTSGIKKALWC 152
++ H+ + + + ++ + L T +D ++ + Y +N GHT A+WC
Sbjct: 4 ILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGT--YMGHTG----AVWC 57
Query: 153 SE----DKQILSAD-DKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIA 207
+ K +L+ D + RLWD T ++ L N +V + + G I++ + + +
Sbjct: 58 VDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMG 117
Query: 208 FHSAVSLDPIKS----------FEAPAT---INSASLHPEKEFLVAGGEDFKLYKYDYNS 254
+ VS ++ + P I SA P E ++AG E +L +Y S
Sbjct: 118 YQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKS 177
Query: 255 GEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQT 294
GE L + K H I+ ++ S D ++ + S+D T +L+ +
Sbjct: 178 GEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDS 217
Score = 40.4 bits (93), Expect = 0.002
Identities = 20/51 (39%), Positives = 26/51 (50%)
Query: 254 SGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWK 304
+GE L +Y GH G + CV D + +GS D + RLW GK L K
Sbjct: 41 NGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLK 91
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 97.4 bits (241), Expect = 2e-20
Identities = 75/286 (26%), Positives = 126/286 (44%), Gaps = 35/286 (12%)
Query: 13 HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72
HT V FS G + S D + + +TG+ + H+ V + D
Sbjct: 614 HTDAVYHACFS---EDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
Query: 73 KAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLL--TGGQDKLLRIYDL 129
AT + D K+W++++G+ + T H V FT S++LL TG D L+++DL
Sbjct: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 730
Query: 130 NKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSLNFNMSVSS 188
N+ E + GHT+ + + +DK + S D T++LWD + E KS+N +
Sbjct: 731 NQKECR-NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789
Query: 189 MEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDFKLY 248
+E DP + E S S + + A K++
Sbjct: 790 LE------------------------DPQEDMEVIVKCCSWSADGARIMVAAKN---KIF 822
Query: 249 KYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQT 294
++ +S ++ +GH +H V FSPDG + + S+D T+RLW+T
Sbjct: 823 LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 868
Score = 60.8 bits (146), Expect = 2e-09
Identities = 50/260 (19%), Positives = 109/260 (41%), Gaps = 19/260 (7%)
Query: 54 TFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKH------------ 101
T GH +V + D A+ +AD T K+WDA S +E ++ K
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797
Query: 102 --IVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQIL 159
IVK ++ D ++ ++K+ +++ + ++ + GH S + ++ + L
Sbjct: 798 EVIVKCCSWSADGARIMVAAKNKIF-LWNTDS-RSKVADCRGHLSWVHGVMFSPDGSSFL 855
Query: 160 -SADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIK 218
S+DD+T+RLW+ + + ++ V + E E++V+
Sbjct: 856 TSSDDQTIRLWETKKVCKNSAVMLKQEVDVV--FQENEVMVLAVDHIRRLQLINGRTGQI 913
Query: 219 SFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGE 278
+ A ++ L P +++ G E+ + + + +S H + ++F+ D +
Sbjct: 914 DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 973
Query: 279 LYASGSEDGTLRLWQTVVGK 298
S S+D +++W + K
Sbjct: 974 TLISSSDDAEIQVWNWQLDK 993
Score = 48.9 bits (115), Expect = 7e-06
Identities = 35/106 (33%), Positives = 55/106 (51%), Gaps = 7/106 (6%)
Query: 32 LISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSG 91
L+S DG + TG+ F+ H+G V ++ DATK ++ +AD TAK+W S
Sbjct: 1015 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW---SF 1071
Query: 92 DELMTL----AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPE 133
D L+ L H V+ F+ DS L TG + +RI++++ E
Sbjct: 1072 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1117
Score = 46.6 bits (109), Expect = 3e-05
Identities = 55/310 (17%), Positives = 109/310 (35%), Gaps = 49/310 (15%)
Query: 33 ISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDA---- 88
I K L D+ + GH V G + D + T++ D T ++W+
Sbjct: 813 IMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVC 872
Query: 89 --------------VSGDELMTLAHKHIVKT---------VDFTQDSN-----------Y 114
+E+M LA HI + +D+ ++ Y
Sbjct: 873 KNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQY 932
Query: 115 LLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALW-----CSEDKQILSADDKTVRLW 169
+ G ++ + I +L KK +W E I S+DD +++W
Sbjct: 933 IAFGDENGAIEILELVNNRIFQSRFQH-----KKTVWHIQFTADEKTLISSSDDAEIQVW 987
Query: 170 DHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEA-PATINS 228
+ + +V + +L ++ ++ + ++ + K F T+ S
Sbjct: 988 NWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLS 1047
Query: 229 ASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGT 288
+ + + D + ++ L +GH G + C FS D L A+G ++G
Sbjct: 1048 CDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGE 1107
Query: 289 LRLWQTVVGK 298
+R+W G+
Sbjct: 1108 IRIWNVSNGE 1117
Score = 35.8 bits (81), Expect = 0.059
Identities = 17/57 (29%), Positives = 28/57 (49%)
Query: 242 GEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
G D L + +GE+L K H + C FS D A+ S D +++W ++ G+
Sbjct: 634 GADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGE 690
Score = 35.0 bits (79), Expect = 0.10
Identities = 43/249 (17%), Positives = 91/249 (36%), Gaps = 14/249 (5%)
Query: 58 HKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLT 117
HK VW D +++ D +VW+ + H+ VK ++S LL+
Sbjct: 959 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLS 1017
Query: 118 GGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEV 177
D ++++++ E + + + + K ++ DKT ++W + +
Sbjct: 1018 WSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL 1077
Query: 178 KSLN-----FNMSVSSMEYI------PEGEILVITYGRSIAFHSAVSLDPIKSFEAPATI 226
L S S++ GEI + H L + +
Sbjct: 1078 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1137
Query: 227 NSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED 286
P+ + L++ G K ++ +GE +++ + + + SPD + Y +
Sbjct: 1138 TDLCFSPDGKMLISAGGYIKW--WNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNL 1195
Query: 287 GTLRLWQTV 295
G L + QT+
Sbjct: 1196 GILYILQTL 1204
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 97.4 bits (241), Expect = 2e-20
Identities = 75/286 (26%), Positives = 126/286 (44%), Gaps = 35/286 (12%)
Query: 13 HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72
HT V FS G + S D + + +TG+ + H+ V + D
Sbjct: 603 HTDAVYHACFS---EDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
Query: 73 KAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLL--TGGQDKLLRIYDL 129
AT + D K+W++++G+ + T H V FT S++LL TG D L+++DL
Sbjct: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719
Query: 130 NKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSLNFNMSVSS 188
N+ E + GHT+ + + +DK + S D T++LWD + E KS+N +
Sbjct: 720 NQKECR-NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
Query: 189 MEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDFKLY 248
+E DP + E S S + + A K++
Sbjct: 779 LE------------------------DPQEDMEVIVKCCSWSADGARIMVAAKN---KIF 811
Query: 249 KYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQT 294
++ +S ++ +GH +H V FSPDG + + S+D T+RLW+T
Sbjct: 812 LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 857
Score = 60.8 bits (146), Expect = 2e-09
Identities = 50/260 (19%), Positives = 109/260 (41%), Gaps = 19/260 (7%)
Query: 54 TFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKH------------ 101
T GH +V + D A+ +AD T K+WDA S +E ++ K
Sbjct: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
Query: 102 --IVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQIL 159
IVK ++ D ++ ++K+ +++ + ++ + GH S + ++ + L
Sbjct: 787 EVIVKCCSWSADGARIMVAAKNKIF-LWNTDS-RSKVADCRGHLSWVHGVMFSPDGSSFL 844
Query: 160 -SADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIK 218
S+DD+T+RLW+ + + ++ V + E E++V+
Sbjct: 845 TSSDDQTIRLWETKKVCKNSAVMLKQEVDVV--FQENEVMVLAVDHIRRLQLINGRTGQI 902
Query: 219 SFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGE 278
+ A ++ L P +++ G E+ + + + +S H + ++F+ D +
Sbjct: 903 DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 962
Query: 279 LYASGSEDGTLRLWQTVVGK 298
S S+D +++W + K
Sbjct: 963 TLISSSDDAEIQVWNWQLDK 982
Score = 48.9 bits (115), Expect = 7e-06
Identities = 35/106 (33%), Positives = 55/106 (51%), Gaps = 7/106 (6%)
Query: 32 LISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSG 91
L+S DG + TG+ F+ H+G V ++ DATK ++ +AD TAK+W S
Sbjct: 1004 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW---SF 1060
Query: 92 DELMTL----AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPE 133
D L+ L H V+ F+ DS L TG + +RI++++ E
Sbjct: 1061 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1106
Score = 46.6 bits (109), Expect = 3e-05
Identities = 55/310 (17%), Positives = 109/310 (35%), Gaps = 49/310 (15%)
Query: 33 ISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDA---- 88
I K L D+ + GH V G + D + T++ D T ++W+
Sbjct: 802 IMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVC 861
Query: 89 --------------VSGDELMTLAHKHIVKT---------VDFTQDSN-----------Y 114
+E+M LA HI + +D+ ++ Y
Sbjct: 862 KNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQY 921
Query: 115 LLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALW-----CSEDKQILSADDKTVRLW 169
+ G ++ + I +L KK +W E I S+DD +++W
Sbjct: 922 IAFGDENGAIEILELVNNRIFQSRFQH-----KKTVWHIQFTADEKTLISSSDDAEIQVW 976
Query: 170 DHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEA-PATINS 228
+ + +V + +L ++ ++ + ++ + K F T+ S
Sbjct: 977 NWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLS 1036
Query: 229 ASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGT 288
+ + + D + ++ L +GH G + C FS D L A+G ++G
Sbjct: 1037 CDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGE 1096
Query: 289 LRLWQTVVGK 298
+R+W G+
Sbjct: 1097 IRIWNVSNGE 1106
Score = 35.8 bits (81), Expect = 0.059
Identities = 17/57 (29%), Positives = 28/57 (49%)
Query: 242 GEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
G D L + +GE+L K H + C FS D A+ S D +++W ++ G+
Sbjct: 623 GADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGE 679
Score = 35.0 bits (79), Expect = 0.10
Identities = 43/249 (17%), Positives = 91/249 (36%), Gaps = 14/249 (5%)
Query: 58 HKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLT 117
HK VW D +++ D +VW+ + H+ VK ++S LL+
Sbjct: 948 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLS 1006
Query: 118 GGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEV 177
D ++++++ E + + + + K ++ DKT ++W + +
Sbjct: 1007 WSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL 1066
Query: 178 KSLN-----FNMSVSSMEYI------PEGEILVITYGRSIAFHSAVSLDPIKSFEAPATI 226
L S S++ GEI + H L + +
Sbjct: 1067 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1126
Query: 227 NSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED 286
P+ + L++ G K ++ +GE +++ + + + SPD + Y +
Sbjct: 1127 TDLCFSPDGKMLISAGGYIKW--WNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNL 1184
Query: 287 GTLRLWQTV 295
G L + QT+
Sbjct: 1185 GILYILQTL 1193
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 96.7 bits (239), Expect = 3e-20
Identities = 77/290 (26%), Positives = 129/290 (44%), Gaps = 8/290 (2%)
Query: 9 TCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLN 68
T GH V +AF+ PYG + + D L +TG TF GH + + N
Sbjct: 129 TLEGHRNVVYAIAFNN--PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFN 186
Query: 69 KDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIY 127
+T AT + D TAK+WD +G+E+ TL H + ++ F + ++TG D + ++
Sbjct: 187 PQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Query: 128 DLNKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSL---NFN 183
D + + + GH + I A + + IL+ DKT +LWD V +L +
Sbjct: 247 DADTGR-KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE 305
Query: 184 MSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGE 243
+ S +Y + G + F +A K I+ S +P+ L+ G
Sbjct: 306 ILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSS 365
Query: 244 DFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQ 293
D +D +G+ L+ +GH I F+ G + +GS+D T R+W+
Sbjct: 366 DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 69.3 bits (168), Expect = 5e-12
Identities = 65/258 (25%), Positives = 116/258 (44%), Gaps = 14/258 (5%)
Query: 67 LNKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQD-SNYLLTGGQDKLL 124
LNK + T + D T K+WD SG+EL TL H+++V + F + + TG DK
Sbjct: 100 LNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTC 159
Query: 125 RIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSLN-F 182
+++ + + GHT+ I + + + + D T +LWD EV +L
Sbjct: 160 KLWSVETGKCY-HTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGH 218
Query: 183 NMSVSSMEYIPEGE-ILVITYGRSIAFHSAVSLDPIKSFEAP-ATINSASLHPEKEFLVA 240
+ + S+ + G+ I+ ++ ++ A + + A I+SAS + + ++
Sbjct: 219 SAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILT 278
Query: 241 GGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTY 300
G D +D +G+ + + GH I F G+L A+ S DGT R++
Sbjct: 279 GSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR--- 335
Query: 301 GLWKCVLP-EEDSGELAK 317
KC+ E GE++K
Sbjct: 336 ---KCIAKLEGHEGEISK 350
Score = 30.4 bits (67), Expect = 2.5
Identities = 13/37 (35%), Positives = 19/37 (51%)
Query: 262 KGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
K H P+ V + G + +GS D T +LW T G+
Sbjct: 89 KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGE 125
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 94.0 bits (232), Expect = 2e-19
Identities = 78/300 (26%), Positives = 129/300 (43%), Gaps = 33/300 (11%)
Query: 12 GHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDA 71
GH + L S P G L +A D ML ++GHK V +
Sbjct: 16 GHKAAITSLDLS---PNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHG 72
Query: 72 TKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLN 130
A+A+ D T ++W + AH V++VDF+ D +L T +DK ++++ +
Sbjct: 73 NLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY 132
Query: 131 KPEAEPKEISGHTSGIKKALWCSEDKQILS-ADDKTVRLWDHATMTEVKSLNFNMSVSSM 189
+ + + HT ++ A + + + I+S ++DKT+++WD V NF+ SV
Sbjct: 133 R-QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN--NFSDSVGFA 189
Query: 190 EYI---PEGEILVITYGRSIAFHSAVSLDPIKSFEAPAT------------INSASLHPE 234
++ P G + SA S +K ++ +N S HP
Sbjct: 190 NFVDFNPSGTCIA----------SAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS 239
Query: 235 KEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQT 294
+L+ D L D G + + +GH GP+ V FS GEL+ASG D + LW+T
Sbjct: 240 GNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRT 299
Score = 83.2 bits (204), Expect = 3e-16
Identities = 55/249 (22%), Positives = 119/249 (47%), Gaps = 6/249 (2%)
Query: 55 FLGHKGAVWGATLNKDATKAATAAADFTAKVWD-AVSGDELMTLAHKHIVKTVDFTQDSN 113
F GHK A+ L+ + + ATA+ D +W+ + HK +V +V F+ N
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 114 YLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHA 172
L + +D+ +R++ +K + E HT+ ++ + ++ + + +A +DK++++W
Sbjct: 74 LLASASRDRTVRLWIPDK-RGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY 132
Query: 173 TMTEVKSLNFNMS-VSSMEYIPEGEILV-ITYGRSIAFHSAVSLDPIKSF-EAPATINSA 229
+ SL + V ++ P+G ++V + ++I + + +F ++ N
Sbjct: 133 RQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFV 192
Query: 230 SLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTL 289
+P + + G D + +D + L+ Y+ H G ++C+ F P G + S DGTL
Sbjct: 193 DFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTL 252
Query: 290 RLWQTVVGK 298
++ + G+
Sbjct: 253 KILDLLEGR 261
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 93.2 bits (230), Expect = 3e-19
Identities = 66/250 (26%), Positives = 114/250 (45%), Gaps = 16/250 (6%)
Query: 55 FLGHKGAVWGATLNKDATKAATAAADFTAKVW-DAVSGDELMTLAHKHIVKTVDFTQDSN 113
F GHK AV + A+ + D T ++W V G+ + AH V++V F D
Sbjct: 19 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQ 78
Query: 114 YLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHA 172
+T DK ++++ ++ + +S H + ++ A + + + I+SA DDKTV+LWD +
Sbjct: 79 SFVTASDDKTVKVWATHRQKFL-FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 137
Query: 173 TMTEVKSL-NFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEA-------PA 224
+ V S V+ +++ P G + + + V + +++ A
Sbjct: 138 SRECVHSYCEHGGFVTYVDFHPSGTCIA-----AAGMDNTVKVWDVRTHRLLQHYQLHSA 192
Query: 225 TINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGS 284
+N S HP +L+ D L D G L + GH GP V FS GE +ASG
Sbjct: 193 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 252
Query: 285 EDGTLRLWQT 294
D + +W++
Sbjct: 253 SDEQVMVWKS 262
Score = 73.9 bits (180), Expect = 2e-13
Identities = 50/204 (24%), Positives = 100/204 (49%), Gaps = 5/204 (2%)
Query: 99 HKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQI 158
HK V V+F+ + L +G +DK +RI+ N + E HT+ ++ +CS+ +
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNV-KGESTVFRAHTATVRSVHFCSDGQSF 80
Query: 159 LSA-DDKTVRLWDHATMTEVKSLNFNMS-VSSMEYIPEGEILV-ITYGRSIAFHSAVSLD 215
++A DDKTV++W + SL+ +++ V ++ P+G ++V + +++ S +
Sbjct: 81 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 140
Query: 216 PIKSF-EAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFS 274
+ S+ E + HP + A G D + +D + L+ Y+ H ++ + F
Sbjct: 141 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 200
Query: 275 PDGELYASGSEDGTLRLWQTVVGK 298
P G + S D TL++ + G+
Sbjct: 201 PSGNYLITASSDSTLKILDLMEGR 224
Score = 53.1 bits (126), Expect = 4e-07
Identities = 56/217 (25%), Positives = 85/217 (39%), Gaps = 15/217 (6%)
Query: 26 TPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKV 85
+P G ++SA D L + + + ++ H G V + T A A D T KV
Sbjct: 116 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKV 175
Query: 86 WDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTS 144
WD + L H V + F NYL+T D L+I DL + + GH
Sbjct: 176 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL-LYTLHGHQG 234
Query: 145 GIKKALWCSEDKQILS-ADDKTVRLW-------DHATMTEVKSLNFNMSVSSMEYIPEGE 196
+ + S D+ V +W DH +T+V ++ SSM +PE +
Sbjct: 235 PATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLA-SSMGNLPEVD 293
Query: 197 ILVIT-YGRSIAFHSAVSLDPIKSFEAPATINSASLH 232
V GRS+ +V P + P T+ S H
Sbjct: 294 FPVPPGRGRSV---ESVQSQPQEPVSVPQTLTSTLEH 327
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 93.2 bits (230), Expect = 3e-19
Identities = 66/250 (26%), Positives = 114/250 (45%), Gaps = 16/250 (6%)
Query: 55 FLGHKGAVWGATLNKDATKAATAAADFTAKVW-DAVSGDELMTLAHKHIVKTVDFTQDSN 113
F GHK AV + A+ + D T ++W V G+ + AH V++V F D
Sbjct: 57 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQ 116
Query: 114 YLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHA 172
+T DK ++++ ++ + +S H + ++ A + + + I+SA DDKTV+LWD +
Sbjct: 117 SFVTASDDKTVKVWATHRQKFL-FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 175
Query: 173 TMTEVKSL-NFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEA-------PA 224
+ V S V+ +++ P G + + + V + +++ A
Sbjct: 176 SRECVHSYCEHGGFVTYVDFHPSGTCIA-----AAGMDNTVKVWDVRTHRLLQHYQLHSA 230
Query: 225 TINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGS 284
+N S HP +L+ D L D G L + GH GP V FS GE +ASG
Sbjct: 231 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 290
Query: 285 EDGTLRLWQT 294
D + +W++
Sbjct: 291 SDEQVMVWKS 300
Score = 80.9 bits (198), Expect = 2e-15
Identities = 59/249 (23%), Positives = 115/249 (46%), Gaps = 6/249 (2%)
Query: 55 FLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLA-HKHIVKTVDFTQDSN 113
F GH+ AV + + + A+ + D VW HK V V+F+ +
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 114 YLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHA 172
L +G +DK +RI+ N + E HT+ ++ +CS+ + ++A DDKTV++W
Sbjct: 75 LLASGSRDKTVRIWVPNV-KGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133
Query: 173 TMTEVKSLNFNMS-VSSMEYIPEGEILV-ITYGRSIAFHSAVSLDPIKSF-EAPATINSA 229
+ SL+ +++ V ++ P+G ++V + +++ S + + S+ E +
Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYV 193
Query: 230 SLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTL 289
HP + A G D + +D + L+ Y+ H ++ + F P G + S D TL
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
Query: 290 RLWQTVVGK 298
++ + G+
Sbjct: 254 KILDLMEGR 262
Score = 46.6 bits (109), Expect = 3e-05
Identities = 41/161 (25%), Positives = 62/161 (38%), Gaps = 10/161 (6%)
Query: 26 TPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKV 85
+P G ++SA D L + + + ++ H G V + T A A D T KV
Sbjct: 154 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213
Query: 86 WDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTS 144
WD + L H V + F NYL+T D L+I DL + + GH
Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL-LYTLHGHQG 272
Query: 145 GIKKALWCSEDKQILS-ADDKTVRLW-------DHATMTEV 177
+ + S D+ V +W DH +T+V
Sbjct: 273 PATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKV 313
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 93.2 bits (230), Expect = 3e-19
Identities = 66/250 (26%), Positives = 114/250 (45%), Gaps = 16/250 (6%)
Query: 55 FLGHKGAVWGATLNKDATKAATAAADFTAKVW-DAVSGDELMTLAHKHIVKTVDFTQDSN 113
F GHK AV + A+ + D T ++W V G+ + AH V++V F D
Sbjct: 57 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQ 116
Query: 114 YLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHA 172
+T DK ++++ ++ + +S H + ++ A + + + I+SA DDKTV+LWD +
Sbjct: 117 SFVTASDDKTVKVWATHRQKFL-FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 175
Query: 173 TMTEVKSL-NFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEA-------PA 224
+ V S V+ +++ P G + + + V + +++ A
Sbjct: 176 SRECVHSYCEHGGFVTYVDFHPSGTCIA-----AAGMDNTVKVWDVRTHRLLQHYQLHSA 230
Query: 225 TINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGS 284
+N S HP +L+ D L D G L + GH GP V FS GE +ASG
Sbjct: 231 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 290
Query: 285 EDGTLRLWQT 294
D + +W++
Sbjct: 291 SDEQVMVWKS 300
Score = 80.9 bits (198), Expect = 2e-15
Identities = 59/249 (23%), Positives = 115/249 (46%), Gaps = 6/249 (2%)
Query: 55 FLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLA-HKHIVKTVDFTQDSN 113
F GH+ AV + + + A+ + D VW HK V V+F+ +
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 114 YLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHA 172
L +G +DK +RI+ N + E HT+ ++ +CS+ + ++A DDKTV++W
Sbjct: 75 LLASGSRDKTVRIWVPNV-KGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133
Query: 173 TMTEVKSLNFNMS-VSSMEYIPEGEILV-ITYGRSIAFHSAVSLDPIKSF-EAPATINSA 229
+ SL+ +++ V ++ P+G ++V + +++ S + + S+ E +
Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYV 193
Query: 230 SLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTL 289
HP + A G D + +D + L+ Y+ H ++ + F P G + S D TL
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
Query: 290 RLWQTVVGK 298
++ + G+
Sbjct: 254 KILDLMEGR 262
Score = 53.1 bits (126), Expect = 4e-07
Identities = 56/217 (25%), Positives = 85/217 (39%), Gaps = 15/217 (6%)
Query: 26 TPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKV 85
+P G ++SA D L + + + ++ H G V + T A A D T KV
Sbjct: 154 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213
Query: 86 WDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTS 144
WD + L H V + F NYL+T D L+I DL + + GH
Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL-LYTLHGHQG 272
Query: 145 GIKKALWCSEDKQILS-ADDKTVRLW-------DHATMTEVKSLNFNMSVSSMEYIPEGE 196
+ + S D+ V +W DH +T+V ++ SSM +PE +
Sbjct: 273 PATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLA-SSMGNLPEVD 331
Query: 197 ILVIT-YGRSIAFHSAVSLDPIKSFEAPATINSASLH 232
V GRS+ +V P + P T+ S H
Sbjct: 332 FPVPPGRGRSV---ESVQSQPQEPVSVPQTLTSTLEH 365
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 91.7 bits (226), Expect = 9e-19
Identities = 69/275 (25%), Positives = 126/275 (45%), Gaps = 8/275 (2%)
Query: 23 SGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFT 82
S +P G L++ +DG + +G + GH G V + D A+A+ D T
Sbjct: 27 SAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCT 86
Query: 83 AKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISG 141
++WD L L H+ V+TV F+ DS L +GG DK + ++D+ + + + G
Sbjct: 87 VRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQML-RLLVG 145
Query: 142 HTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSLN----FNMSVSSMEYIPEGE 196
H I+ + + + + D TV +WD +T S + ++S + Y G
Sbjct: 146 HRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGL 205
Query: 197 ILVITYGRSIAFHSAVSLDPIKSFEAPAT-INSASLHPEKEFLVAGGEDFKLYKYDYNSG 255
+ ++ ++I + + + T + S + P++ +L + G + +D N+G
Sbjct: 206 LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTG 265
Query: 256 EELESYKGHFGPIHCVRFSPDGELYASGSEDGTLR 290
+ LE+ KG H F+PDG++ SG+ D T R
Sbjct: 266 KCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 65.1 bits (157), Expect = 9e-11
Identities = 31/73 (42%), Positives = 44/73 (60%)
Query: 226 INSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSE 285
+NS++ P+ + L+ G ED +Y ++ SG+ L GH GP+ RFSPDG L+AS S
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASC 83
Query: 286 DGTLRLWQTVVGK 298
D T+RLW K
Sbjct: 84 DCTVRLWDVARAK 96
Score = 50.4 bits (119), Expect = 2e-06
Identities = 48/195 (24%), Positives = 74/195 (37%), Gaps = 41/195 (21%)
Query: 99 HKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQI 158
H V + F+ D LLTG +D + ++ + + + GHT +K + +
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR-LGGHTGPVKFCRFSPDGHLF 78
Query: 159 LSAD-DKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPI 217
SA D TVRLWD A A L +
Sbjct: 79 ASASCDCTVRLWDVAR-------------------------------------AKCLRVL 101
Query: 218 KSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDG 277
K + ++ + S P+ L +GG D ++ +D SG+ L GH I FSP
Sbjct: 102 KGHQR--SVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTV 159
Query: 278 ELYASGSEDGTLRLW 292
A+GS D T+ +W
Sbjct: 160 NCLATGSWDSTVHIW 174
Score = 37.7 bits (86), Expect = 0.015
Identities = 17/41 (41%), Positives = 26/41 (63%), Gaps = 2/41 (4%)
Query: 264 HFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWK 304
H G ++ FSPDG++ +GSEDG + W+T G+ LW+
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQL--LWR 58
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 91.3 bits (225), Expect = 1e-18
Identities = 85/287 (29%), Positives = 116/287 (40%), Gaps = 46/287 (16%)
Query: 8 LTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATL 67
LT GHT + D F P G L ++ D L GD I TF GH AVW T
Sbjct: 388 LTGFGHTDWLSDCCFH---PSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTW 444
Query: 68 NKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRI 126
+ A+++ D T+K+WD S TL H V +++F SN LLT DK L I
Sbjct: 445 HSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSI 504
Query: 127 YDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTV-RLWDHATMTEVKSLNFNMS 185
+D E + + GH I A++ I S D V +LWD + + S++ S
Sbjct: 505 WDARTGICE-QSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPS 563
Query: 186 VSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDF 245
P E+ + GR +A S +
Sbjct: 564 -------PGNEVNFDSSGRVLAQASGNGV------------------------------- 585
Query: 246 KLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLW 292
++ D SGE + GH H V FS DGE+ SG DGT+R W
Sbjct: 586 -IHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 35.8 bits (81), Expect = 0.059
Identities = 43/200 (21%), Positives = 71/200 (35%), Gaps = 41/200 (20%)
Query: 99 HKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWC-SEDKQ 157
H+ V V + L++ G+D+L ++ L K GHT + + S DK
Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGF-GHTDWLSDCCFHPSGDKL 409
Query: 158 ILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPI 217
S+ D TV+LWD + +G+ ++ G S A
Sbjct: 410 ATSSGDTTVKLWD---------------------LCKGDCILTFEGHSRA---------- 438
Query: 218 KSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDG 277
+ S + H F+ + D +D NS + GH ++ + F P
Sbjct: 439 --------VWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFS 490
Query: 278 ELYASGSEDGTLRLWQTVVG 297
+ S D TL +W G
Sbjct: 491 NTLLTSSADKTLSIWDARTG 510
Score = 35.8 bits (81), Expect = 0.059
Identities = 24/88 (27%), Positives = 37/88 (42%), Gaps = 8/88 (9%)
Query: 226 INSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSE 285
++ S+ P K+ LV+ GED L + GH + F P G+ A+ S
Sbjct: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414
Query: 286 DGTLRLWQ--------TVVGKTYGLWKC 305
D T++LW T G + +W C
Sbjct: 415 DTTVKLWDLCKGDCILTFEGHSRAVWSC 442
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 85.5 bits (210), Expect = 6e-17
Identities = 77/298 (25%), Positives = 140/298 (46%), Gaps = 17/298 (5%)
Query: 9 TCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLN 68
T +GHT+ V + FS P G +L S+ D + G + T GHK + +
Sbjct: 40 TLAGHTKAVSSVKFS---PNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 69 KDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIY 127
D+ +A+ D T K+WD SG L TL H + V +F SN +++G D+ +RI+
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 128 DLNKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSL--NFNM 184
D+ + K + H+ + + + I+S+ D R+WD A+ +K+L + N
Sbjct: 157 DVKTGKC-LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
Query: 185 SVSSMEYIPEGE-ILVITYGRSIAFHSAVSLDPIKSF-----EAPATINSASLHPEKEFL 238
VS +++ P G+ IL T ++ +K++ E + S+ K ++
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK-WI 274
Query: 239 VAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGS--EDGTLRLWQT 294
V+G ED +Y ++ + E ++ +GH + P + AS + D T++LW++
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
Score = 74.3 bits (181), Expect = 1e-13
Identities = 57/209 (27%), Positives = 107/209 (51%), Gaps = 7/209 (3%)
Query: 96 TLA-HKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSE 154
TLA H V +V F+ + +L + DKL++I+ + E K ISGH GI W S+
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSD 98
Query: 155 DKQILSA-DDKTVRLWDHATMTEVKSLNFNMS-VSSMEYIPEGEILVI-TYGRSIAFHSA 211
++SA DDKT+++WD ++ +K+L + + V + P+ ++V ++ S+
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 212 VSLDPIKSFEAPAT-INSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGP-IH 269
+ +K+ A + +++ + + +V+ D +D SG+ L++ P +
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218
Query: 270 CVRFSPDGELYASGSEDGTLRLWQTVVGK 298
V+FSP+G+ + + D TL+LW GK
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGK 247
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 85.5 bits (210), Expect = 6e-17
Identities = 77/298 (25%), Positives = 140/298 (46%), Gaps = 17/298 (5%)
Query: 9 TCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLN 68
T +GHT+ V + FS P G +L S+ D + G + T GHK + +
Sbjct: 40 TLAGHTKAVSSVKFS---PNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 69 KDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIY 127
D+ +A+ D T K+WD SG L TL H + V +F SN +++G D+ +RI+
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 128 DLNKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSL--NFNM 184
D+ + K + H+ + + + I+S+ D R+WD A+ +K+L + N
Sbjct: 157 DVKTGKC-LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
Query: 185 SVSSMEYIPEGE-ILVITYGRSIAFHSAVSLDPIKSF-----EAPATINSASLHPEKEFL 238
VS +++ P G+ IL T ++ +K++ E + S+ K ++
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK-WI 274
Query: 239 VAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGS--EDGTLRLWQT 294
V+G ED +Y ++ + E ++ +GH + P + AS + D T++LW++
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
Score = 74.3 bits (181), Expect = 1e-13
Identities = 57/209 (27%), Positives = 107/209 (51%), Gaps = 7/209 (3%)
Query: 96 TLA-HKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSE 154
TLA H V +V F+ + +L + DKL++I+ + E K ISGH GI W S+
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSD 98
Query: 155 DKQILSA-DDKTVRLWDHATMTEVKSLNFNMS-VSSMEYIPEGEILVI-TYGRSIAFHSA 211
++SA DDKT+++WD ++ +K+L + + V + P+ ++V ++ S+
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 212 VSLDPIKSFEAPAT-INSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGP-IH 269
+ +K+ A + +++ + + +V+ D +D SG+ L++ P +
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218
Query: 270 CVRFSPDGELYASGSEDGTLRLWQTVVGK 298
V+FSP+G+ + + D TL+LW GK
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGK 247
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 84.7 bits (208), Expect = 1e-16
Identities = 70/252 (27%), Positives = 110/252 (43%), Gaps = 15/252 (5%)
Query: 54 TFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSN 113
TFL + + D++ A AD T +VW +V+ +L ++ + +D D
Sbjct: 465 TFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVW-SVTPKKLRSVKQASDLSLIDKESD-- 521
Query: 114 YLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHA 172
D L RI D K +E K + GH+ + A + + +LS+ +D TVRLW
Sbjct: 522 -------DVLERIMD-EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ 573
Query: 173 TMT-EVKSLNFNMSVSSMEYIPEGEILVIT-YGRSIAFHSAVSLDPIKSFEAP-ATINSA 229
T T V N V ++ P G V + R + P++ F A +N
Sbjct: 574 TFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCT 633
Query: 230 SLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTL 289
HP ++ G D + +D +G + + GH GPIH + FSP+G A+G+ DG +
Sbjct: 634 RFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV 693
Query: 290 RLWQTVVGKTYG 301
LW G G
Sbjct: 694 LLWDIGHGLMVG 705
Score = 78.6 bits (192), Expect = 8e-15
Identities = 69/277 (24%), Positives = 112/277 (40%), Gaps = 51/277 (18%)
Query: 57 GHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYL 115
GH G V+GA+ + D +++ D T ++W + L+ H + V F+ Y
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600
Query: 116 LTGGQDKLLRIYDLNKPEAEPKEI-SGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHAT 173
++GG D++ R++ + +P I +GH + + + + + D+TVRLWD
Sbjct: 601 VSGGHDRVARLWATD--HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD--- 655
Query: 174 MTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHP 233
+ G + I G I+S + P
Sbjct: 656 ------------------VLNGNCVRIFTGHK------------------GPIHSLTFSP 679
Query: 234 EKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQ 293
FL G D ++ +D G + KGH + +RFS DGE+ ASGS D T+RLW
Sbjct: 680 NGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Query: 294 TVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEEL 330
+ K + E D A I PE ++E L
Sbjct: 740 AI--KAFEDL-----ETDDFTTATGHINLPENSQELL 769
Score = 73.2 bits (178), Expect = 3e-13
Identities = 58/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 12 GHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDA 71
GH PV D FS PYGY+ +S D L D + F GH V + ++
Sbjct: 583 GHNYPVWDTQFS---PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNS 639
Query: 72 TKAATAAADFTAKVWDAVSGDEL-MTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLN 130
AT +AD T ++WD ++G+ + + HK + ++ F+ + +L TG D + ++D+
Sbjct: 640 NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG 699
Query: 131 KPEAEPKEISGHTSGIKKALWCSEDKQILSAD--DKTVRLWDHATMTEVKSLNFNMSVSS 188
E+ GHT + +L S D +IL++ D TVRLWD E + + +
Sbjct: 700 H-GLMVGELKGHTDTV-CSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATG 757
Query: 189 MEYIPEG--EILVITY 202
+PE E+L+ TY
Sbjct: 758 HINLPENSQELLLGTY 773
Score = 56.6 bits (135), Expect = 3e-08
Identities = 60/216 (27%), Positives = 93/216 (43%), Gaps = 17/216 (7%)
Query: 12 GHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDA 71
GH+ PV +FS P +L+S+ +DG L T + + GH VW +
Sbjct: 541 GHSGPVYGASFS---PDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG 597
Query: 72 TKAATAAADFTAKVWDAVSGDELMTLA-HKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLN 130
+ D A++W L A H V F +SNY+ TG D+ +R++D+
Sbjct: 598 YYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVL 657
Query: 131 KPEAEPKEISGHTSGIKKALWCSEDKQILS-ADDKTVRLWD--HATMT-EVKSLNFNMSV 186
+ +GH I + + + + A D V LWD H M E+K +V
Sbjct: 658 NGNC-VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELK--GHTDTV 714
Query: 187 SSMEYIPEGEILVITYGRSIAFHSAVSL-DPIKSFE 221
S+ + +GEIL S + + V L D IK+FE
Sbjct: 715 CSLRFSRDGEILA-----SGSMDNTVRLWDAIKAFE 745
Score = 48.1 bits (113), Expect = 1e-05
Identities = 31/109 (28%), Positives = 50/109 (45%), Gaps = 4/109 (3%)
Query: 11 SGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKD 70
+GH P+ L FS P G FL + DG+ +L G +G GH V ++D
Sbjct: 666 TGHKGPIHSLTFS---PNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRD 722
Query: 71 ATKAATAAADFTAKVWDAVSG-DELMTLAHKHIVKTVDFTQDSNYLLTG 118
A+ + D T ++WDA+ ++L T ++ ++S LL G
Sbjct: 723 GEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLG 771
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 82.8 bits (203), Expect = 4e-16
Identities = 76/298 (25%), Positives = 139/298 (46%), Gaps = 17/298 (5%)
Query: 9 TCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLN 68
T GHT V + FS P G +L S+ D ++ G + T GH + +
Sbjct: 36 TLVGHTEAVSSVKFS---PNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 69 KDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIY 127
D+++ +A+ D T K+WD SG L TL H + V +F SN +++G D+ ++I+
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 128 DLNKPEAEPKEISGHTSGIKKALW-CSEDKQILSADDKTVRLWDHATMTEVKSL--NFNM 184
++ + K +S H+ + + CS + + D R+WD A+ +K+L + N
Sbjct: 153 EVKTGKC-LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP 211
Query: 185 SVSSMEYIPEGE-ILVITYGRSIAFHSAVSLDPIKSF-----EAPATINSASLHPEKEFL 238
VS +++ P G+ IL T ++ +K++ E + S+ K ++
Sbjct: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGK-WI 270
Query: 239 VAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGS--EDGTLRLWQT 294
V+G ED +Y ++ + E ++ +GH + P L AS + D T++LW +
Sbjct: 271 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMS 328
Score = 66.6 bits (161), Expect = 3e-11
Identities = 56/217 (25%), Positives = 104/217 (47%), Gaps = 19/217 (8%)
Query: 97 LAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDK 156
+ H V +V F+ + +L + D+L+ I+ + E K + GH I W S+
Sbjct: 38 VGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE-KTLYGHNLEISDVAWSSDSS 96
Query: 157 QILSA-DDKTVRLWDHATMTEVKSLNFNMS-VSSMEYIPEGEILVITYGRSIAFHSAVSL 214
+++SA DDKT++LWD + +K+L + + V + P +++ S +F V +
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLII-----SGSFDETVKI 151
Query: 215 DPIKSFEAPATINSAS-------LHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGP 267
+K+ + T+++ S + +V+G D +D SG+ L++ P
Sbjct: 152 WEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP 211
Query: 268 -IHCVRFSPDGELYASGSEDGTLRLWQTVVG---KTY 300
+ V+FSP+G+ + + D TL+LW G KTY
Sbjct: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY 248
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 80.1 bits (196), Expect = 3e-15
Identities = 70/285 (24%), Positives = 128/285 (44%), Gaps = 27/285 (9%)
Query: 11 SGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKD 70
SGH PV + F P ++SA +D + +TGD+ T GH +V + +
Sbjct: 105 SGHRSPVTRVIFH---PVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 71 ATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDL 129
A+ +AD T K+WD + + T+ H H V +V + +++++ +DK ++++++
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV 221
Query: 130 NKPEAEPKEISGHTSGIKKALWCSEDKQILS-ADDKTVRLWDHATM-TEVKSLNFNMSVS 187
K +GH ++ + I S ++D+TVR+W AT + + V
Sbjct: 222 QTGYC-VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280
Query: 188 SMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDFKL 247
+ + PE +S++S EA + S P FL++G D +
Sbjct: 281 CISWAPESS------------YSSIS-------EATGSETKKSGKP-GPFLLSGSRDKTI 320
Query: 248 YKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLW 292
+D ++G L + GH + V F G+ S ++D TLR+W
Sbjct: 321 KMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 76.3 bits (186), Expect = 4e-14
Identities = 57/195 (29%), Positives = 96/195 (49%), Gaps = 26/195 (13%)
Query: 9 TCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLN 68
T GH V +A I P G ++SA +D + + TG + TF GH+ V N
Sbjct: 187 TMHGHDHNVSSVA---IMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPN 243
Query: 69 KDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNY------------- 114
+D T A+ + D T +VW + + L H+H+V+ + + +S+Y
Sbjct: 244 QDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKK 303
Query: 115 -------LLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILS-ADDKTV 166
LL+G +DK ++++D++ + GH + ++ L+ S K ILS ADDKT+
Sbjct: 304 SGKPGPFLLSGSRDKTIKMWDVSTGMC-LMTLVGHDNWVRGVLFHSGGKFILSCADDKTL 362
Query: 167 RLWDHATMTEVKSLN 181
R+WD+ +K+LN
Sbjct: 363 RVWDYKNKRCMKTLN 377
Score = 56.6 bits (135), Expect = 3e-08
Identities = 41/167 (24%), Positives = 82/167 (49%), Gaps = 14/167 (8%)
Query: 135 EPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHATMTEVKSLNFNM-SVSSMEYI 192
E +SGH S + + ++ ++SA +D T+++WD+ T ++L + SV + +
Sbjct: 100 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD 159
Query: 193 PEGEILVITYGRSIAFHSAVSLDPIKSFEAPAT-------INSASLHPEKEFLVAGGEDF 245
G++L S + + L + FE T ++S ++ P + +V+ D
Sbjct: 160 HSGKLLA-----SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDK 214
Query: 246 KLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLW 292
+ ++ +G ++++ GH + VR + DG L AS S D T+R+W
Sbjct: 215 TIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
Score = 52.8 bits (125), Expect = 5e-07
Identities = 30/101 (29%), Positives = 53/101 (52%), Gaps = 1/101 (0%)
Query: 29 GYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDA 88
G FL+S +D + TG + T +GH V G + + A D T +VWD
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 89 VSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYD 128
+ + TL AH+H V ++DF + + Y++TG D+ +++++
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 47.8 bits (112), Expect = 1e-05
Identities = 57/267 (21%), Positives = 99/267 (37%), Gaps = 28/267 (10%)
Query: 39 GKPMLRQGDTGDWIG------TFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGD 92
G P+ ++ D +WI GH+ V + + +A+ D T KVWD +GD
Sbjct: 82 GGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGD 141
Query: 93 ELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALW 151
TL H V+ + F L + D ++++D E + + GH +
Sbjct: 142 FERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECI-RTMHGHDHNVSSVAI 200
Query: 152 CSEDKQILSAD-DKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHS 210
I+SA DKT+++W+ T VK+ + M + L+ S +
Sbjct: 201 MPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA----SCSNDQ 256
Query: 211 AVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHC 270
V + + + E A + H ++ + +G E + G GP
Sbjct: 257 TVRVWVVATKECKAELRE---HEHVVECISWAPESSYSSISEATGSETKK-SGKPGPF-- 310
Query: 271 VRFSPDGELYASGSEDGTLRLWQTVVG 297
SGS D T+++W G
Sbjct: 311 ---------LLSGSRDKTIKMWDVSTG 328
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 79.3 bits (194), Expect = 5e-15
Identities = 79/294 (26%), Positives = 132/294 (44%), Gaps = 30/294 (10%)
Query: 26 TPYGYFLISACKDGKPMLRQGDTG--------DWIGTFLGHKGAVWGATLNKDATKAATA 77
+P G +L++ DG + TG F+ AV ++D AT
Sbjct: 223 SPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATG 282
Query: 78 AADFTAKVWDAVSGDELMTL--AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAE 135
A D KVW SG L AH V + F++DS+ +L+ D+ +RI+ L K
Sbjct: 283 AQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGL-KSGKT 341
Query: 136 PKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATM---TEVKSLNF----NMSVS 187
KE GH+S + +A + + I+SA D TV++W+ T KSL +++V+
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVN 401
Query: 188 SMEYIPEGEILVITYGRSIAFHSAVSLDP----IKSFEAPATINS----ASLHPEKEFLV 239
S+ +P+ + RS ++ V ++ ++SF + +L P E++
Sbjct: 402 SVILLPKNPEHFVVCNRS---NTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIY 458
Query: 240 AGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQ 293
GEDF LY + +G+ + H + + P L A+ SEDG L+LW+
Sbjct: 459 CVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 512
Score = 38.9 bits (89), Expect = 0.007
Identities = 15/36 (41%), Positives = 20/36 (55%)
Query: 263 GHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
G + C RFSPDG+ +GS DG + +W GK
Sbjct: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGK 247
Score = 37.0 bits (84), Expect = 0.026
Identities = 20/87 (22%), Positives = 43/87 (49%), Gaps = 8/87 (9%)
Query: 220 FEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHF--------GPIHCV 271
F + + A P+ ++LV G D + +++ +G+ + K + C+
Sbjct: 211 FGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM 270
Query: 272 RFSPDGELYASGSEDGTLRLWQTVVGK 298
FS D E+ A+G++DG +++W+ G+
Sbjct: 271 CFSRDTEMLATGAQDGKIKVWKIQSGQ 297
Score = 35.8 bits (81), Expect = 0.059
Identities = 21/67 (31%), Positives = 32/67 (47%), Gaps = 1/67 (1%)
Query: 234 EKEFLVAGGEDFKLYKYDYNSGEELESY-KGHFGPIHCVRFSPDGELYASGSEDGTLRLW 292
+ E L G +D K+ + SG+ L + + H + C+ FS D S S D T+R+
Sbjct: 275 DTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIH 334
Query: 293 QTVVGKT 299
GKT
Sbjct: 335 GLKSGKT 341
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 77.8 bits (190), Expect = 1e-14
Identities = 61/245 (24%), Positives = 115/245 (46%), Gaps = 16/245 (6%)
Query: 52 IGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQ 110
I F H G V G +K + D+ KVW+ L TL H ++T F
Sbjct: 44 IDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHH 103
Query: 111 DSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLW 169
+ ++L+ D+ +R+++ ++GH + A + + ++SA D+TVR+W
Sbjct: 104 EYPWILSASDDQTIRVWNWQSRTCVCV-LTGHNHYVMCAQFHPTEDLVVSASLDQTVRVW 162
Query: 170 DHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSA 229
D + + + N+S ++E G V +G + AV ++ + +N A
Sbjct: 163 DISGLRKK-----NLSPGAVESDVRGITGVDLFGTT----DAVVKHVLEGHDRG--VNWA 211
Query: 230 SLHPEKEFLVAGGED--FKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDG 287
+ HP +V+G +D K+++ + + E+++ +GH+ + C F P EL S SED
Sbjct: 212 AFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDK 271
Query: 288 TLRLW 292
++R+W
Sbjct: 272 SIRVW 276
Score = 41.2 bits (95), Expect = 0.001
Identities = 44/208 (21%), Positives = 86/208 (41%), Gaps = 34/208 (16%)
Query: 3 MRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAV 62
+R+ T GH + F P+ ++SA D + + + GH V
Sbjct: 82 LRRCLFTLLGHLDYIRTTFFHHEYPW---ILSASDDQTIRVWNWQSRTCVCVLTGHNHYV 138
Query: 63 WGATLNKDATKAATAAADFTAKVWD-------------------AVSGDELMTLAH---K 100
A + +A+ D T +VWD ++G +L K
Sbjct: 139 MCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVK 198
Query: 101 HIVKTVD-------FTQDSNYLLTGGQDKLLRIYDLNKPEA-EPKEISGHTSGIKKALWC 152
H+++ D F +++G D+ ++I+ +N+ +A E GH + + A++
Sbjct: 199 HVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFH 258
Query: 153 SEDKQILS-ADDKTVRLWDHATMTEVKS 179
+ ILS ++DK++R+WD + T V++
Sbjct: 259 PRQELILSNSEDKSIRVWDMSKRTGVQT 286
Score = 39.3 bits (90), Expect = 0.005
Identities = 18/83 (21%), Positives = 39/83 (46%), Gaps = 6/83 (7%)
Query: 224 ATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASG 283
A + S HP++ +++ + + +DY ++ + H GP+ + F L+ SG
Sbjct: 10 ARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSG 69
Query: 284 SEDGTLRLWQTVVGKTYGLWKCV 306
+D +++W Y L +C+
Sbjct: 70 GDDYKIKVW------NYKLRRCL 86
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 77.8 bits (190), Expect = 1e-14
Identities = 61/245 (24%), Positives = 115/245 (46%), Gaps = 16/245 (6%)
Query: 52 IGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQ 110
I F H G V G +K + D+ KVW+ L TL H ++T F
Sbjct: 44 IDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHH 103
Query: 111 DSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLW 169
+ ++L+ D+ +R+++ ++GH + A + + ++SA D+TVR+W
Sbjct: 104 EYPWILSASDDQTIRVWNWQSRTCVCV-LTGHNHYVMCAQFHPTEDLVVSASLDQTVRVW 162
Query: 170 DHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSA 229
D + + + N+S ++E G V +G + AV ++ + +N A
Sbjct: 163 DISGLRKK-----NLSPGAVESDVRGITGVDLFGTT----DAVVKHVLEGHDRG--VNWA 211
Query: 230 SLHPEKEFLVAGGED--FKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDG 287
+ HP +V+G +D K+++ + + E+++ +GH+ + C F P EL S SED
Sbjct: 212 AFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDK 271
Query: 288 TLRLW 292
++R+W
Sbjct: 272 SIRVW 276
Score = 41.2 bits (95), Expect = 0.001
Identities = 44/208 (21%), Positives = 86/208 (41%), Gaps = 34/208 (16%)
Query: 3 MRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAV 62
+R+ T GH + F P+ ++SA D + + + GH V
Sbjct: 82 LRRCLFTLLGHLDYIRTTFFHHEYPW---ILSASDDQTIRVWNWQSRTCVCVLTGHNHYV 138
Query: 63 WGATLNKDATKAATAAADFTAKVWD-------------------AVSGDELMTLAH---K 100
A + +A+ D T +VWD ++G +L K
Sbjct: 139 MCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVK 198
Query: 101 HIVKTVD-------FTQDSNYLLTGGQDKLLRIYDLNKPEA-EPKEISGHTSGIKKALWC 152
H+++ D F +++G D+ ++I+ +N+ +A E GH + + A++
Sbjct: 199 HVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFH 258
Query: 153 SEDKQILS-ADDKTVRLWDHATMTEVKS 179
+ ILS ++DK++R+WD + T V++
Sbjct: 259 PRQELILSNSEDKSIRVWDMSKRTGVQT 286
Score = 39.3 bits (90), Expect = 0.005
Identities = 18/83 (21%), Positives = 39/83 (46%), Gaps = 6/83 (7%)
Query: 224 ATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASG 283
A + S HP++ +++ + + +DY ++ + H GP+ + F L+ SG
Sbjct: 10 ARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSG 69
Query: 284 SEDGTLRLWQTVVGKTYGLWKCV 306
+D +++W Y L +C+
Sbjct: 70 GDDYKIKVW------NYKLRRCL 86
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 73.2 bits (178), Expect = 3e-13
Identities = 55/243 (22%), Positives = 97/243 (39%), Gaps = 43/243 (17%)
Query: 54 TFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHI-VKTVDFTQDS 112
T GH ++ D+ +A+ D +WD+ + +++ + + V T +
Sbjct: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG 109
Query: 113 NYLLTGGQDKLLRIYDLNKPEAE---PKEISGHTSGIKKALWCSEDKQILSADDKTVRLW 169
NY+ GG D + IY+L E +E+ GHT + + + + + S+ D T LW
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALW 169
Query: 170 DHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSA 229
D T + + + G+++ S
Sbjct: 170 DIETAQQTTTFTGH----------SGDVM-----------------------------SL 190
Query: 230 SLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTL 289
SL P+ V+G D +D G +S+ GH I+ V F P+G +A+GS+D T
Sbjct: 191 SLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATC 250
Query: 290 RLW 292
RL+
Sbjct: 251 RLF 253
Score = 42.7 bits (99), Expect = 5e-04
Identities = 32/129 (24%), Positives = 52/129 (40%), Gaps = 7/129 (5%)
Query: 47 DTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKT 105
+T TF GH G V +L+ D + A D ++K+WD G + H +
Sbjct: 172 ETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINA 231
Query: 106 VDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTS---GIKKALWCSEDKQILSA- 161
V F + TG D R++DL + + H + GI + + +L+
Sbjct: 232 VSFFPNGYAFATGSDDATCRLFDLRAD--QELLLYSHDNIICGITSVAFSKSGRLLLAGY 289
Query: 162 DDKTVRLWD 170
DD +WD
Sbjct: 290 DDFNCNVWD 298
Score = 41.6 bits (96), Expect = 0.001
Identities = 34/168 (20%), Positives = 68/168 (40%), Gaps = 17/168 (10%)
Query: 137 KEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSLNFNMS-VSSMEYIPE 194
+ + GH + I W + + ++SA D + +WD T ++ ++ S V + Y P
Sbjct: 49 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPS 108
Query: 195 GEILVITYGRSIAFHSAVSLDPIKSFEAPATIN----------SASLHPEKEFLVAGGED 244
G Y + S+ +K+ E ++ S + +V D
Sbjct: 109 GN-----YVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGD 163
Query: 245 FKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLW 292
+D + ++ ++ GH G + + SPD + SG+ D + +LW
Sbjct: 164 TTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLW 211
Score = 36.6 bits (83), Expect = 0.035
Identities = 19/50 (38%), Positives = 25/50 (50%), Gaps = 1/50 (2%)
Query: 80 DFTAKVWDAVSGDELMTLA-HKHIVKTVDFTQDSNYLLTGGQDKLLRIYD 128
DF VWD + GD LA H + V + T D + TG D LRI++
Sbjct: 291 DFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Score = 29.6 bits (65), Expect = 4.2
Identities = 11/33 (33%), Positives = 18/33 (54%)
Query: 262 KGHFGPIHCVRFSPDGELYASGSEDGTLRLWQT 294
+GH I+ + + D L S S+DG L +W +
Sbjct: 52 RGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDS 84
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 73.2 bits (178), Expect = 3e-13
Identities = 64/254 (25%), Positives = 111/254 (43%), Gaps = 18/254 (7%)
Query: 57 GHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGD-ELMTLAHKHIVKTVDFTQDSNYL 115
GH G V + T +AD T K+WD SG +L H V+ V + S YL
Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261
Query: 116 LTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKA-LWCSEDKQILSADDKTVRLWDHATM 174
+ G+DK ++ +DL + + GH S + L + D + + D T R+WD T
Sbjct: 262 FSCGEDKQVKCWDLEYNKV-IRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTK 320
Query: 175 TEVKSLNFNMSVSSMEYIPEGEILVITYGRS--------IAFHSAVSLDPIKSFEAPATI 226
V +L+ + + + E +IT +A + V+L K ++
Sbjct: 321 ASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKK-----SV 375
Query: 227 NSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED 286
+ LHP + + A G + ++ + G +++ GH I+ + + DG L SG+++
Sbjct: 376 RAVVLHP-RHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVL-VSGADN 433
Query: 287 GTLRLWQTVVGKTY 300
GT+ LW G +
Sbjct: 434 GTMHLWDWRTGYNF 447
Score = 50.8 bits (120), Expect = 2e-06
Identities = 46/217 (21%), Positives = 82/217 (37%), Gaps = 48/217 (22%)
Query: 84 KVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHT 143
K++ +SG H V+ + + + +TG D+ ++I+DL + + ++GH
Sbjct: 195 KLYRVISG-------HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLK-LSLTGHI 246
Query: 144 SGIKKALWCSEDKQILSA-DDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITY 202
S ++ + + + S +DK V+ WD L +N +
Sbjct: 247 STVRGVIVSTRSPYLFSCGEDKQVKCWD---------LEYNKVIRH-------------- 283
Query: 203 GRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYK 262
+H +S + LHP + LV D +D + + +
Sbjct: 284 -----YHGHLS-----------AVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLS 327
Query: 263 GHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKT 299
GH + VR +GS D T+RLW V GKT
Sbjct: 328 GHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKT 364
Score = 50.4 bits (119), Expect = 2e-06
Identities = 42/200 (21%), Positives = 85/200 (42%), Gaps = 5/200 (2%)
Query: 1 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKG 60
+A + L+ +GH V + S +PY L S +D + + I + GH
Sbjct: 233 LASGKLKLSLTGHISTVRGVIVSTRSPY---LFSCGEDKQVKCWDLEYNKVIRHYHGHLS 289
Query: 61 AVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLA-HKHIVKTVDFTQDSNYLLTGG 119
AV+G L+ T + D TA++WD + + TL+ H + V TV ++TG
Sbjct: 290 AVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGS 349
Query: 120 QDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKS 179
D +R++DL + ++ H ++ + S ++ W + +++
Sbjct: 350 HDTTIRLWDLVAGKTR-VTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQN 408
Query: 180 LNFNMSVSSMEYIPEGEILV 199
L+ + ++ + + +LV
Sbjct: 409 LSGHNAIINTLTVNSDGVLV 428
Score = 28.9 bits (63), Expect = 7.2
Identities = 30/132 (22%), Positives = 51/132 (38%), Gaps = 14/132 (10%)
Query: 5 QTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWG 64
+T +T + H + V + + P Y S D + D G +I GH +
Sbjct: 363 KTRVTLTNHKKSVRAVV---LHPRHYTFASGSPDNIKQWKFPD-GSFIQNLSGHNAIINT 418
Query: 65 ATLNKDATKAATAAADFTAKVWDAVSGDELM---------TLAHKHIVKTVDFTQDSNYL 115
T+N D + A + T +WD +G +L + + F Q + L
Sbjct: 419 LTVNSDGV-LVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRL 477
Query: 116 LTGGQDKLLRIY 127
LT DK +++Y
Sbjct: 478 LTAEADKTIKVY 489
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 72.4 bits (176), Expect = 6e-13
Identities = 49/201 (24%), Positives = 97/201 (48%), Gaps = 6/201 (2%)
Query: 97 LAHKHIVKTVDFTQDSNYLL-TGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKA-LWCSE 154
+AH V ++ + S LL TGG D + ++ +NKP ++GHTS ++ L E
Sbjct: 17 VAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCI-MSLTGHTSPVESVRLNTPE 75
Query: 155 DKQILSADDKTVRLWDHATMTEVKSL-NFNMSVSSMEYIPEGEILVI-TYGRSIAFHSAV 212
+ + + ++R+WD +++L ++ S+++ P GE + + +I
Sbjct: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
Query: 213 SLDPIKSFEAPA-TINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCV 271
+ + + + P+ ++L + +D + +D +G+ + + GH GP++ V
Sbjct: 136 RKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVV 195
Query: 272 RFSPDGELYASGSEDGTLRLW 292
F P+ L ASGS D T+R W
Sbjct: 196 EFHPNEYLLASGSSDRTIRFW 216
Score = 63.2 bits (152), Expect = 3e-10
Identities = 54/243 (22%), Positives = 98/243 (40%), Gaps = 43/243 (17%)
Query: 52 IGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQ 110
I + GH V LN + + +VWD + L TL HK + ++DF
Sbjct: 56 IMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHP 115
Query: 111 DSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLW 169
++ +G QD ++++D+ + + GH+ ++ + + K + SA DD TV+LW
Sbjct: 116 YGEFVASGSQDTNIKLWDIRRKGCVFR-YRGHSQAVRCLRFSPDGKWLASAADDHTVKLW 174
Query: 170 DHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSA 229
D +T G+ ++ + +N
Sbjct: 175 D-----------------------------LTAGKMMSEFPGHT----------GPVNVV 195
Query: 230 SLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTL 289
HP + L +G D + +D + + +G GP+ V F+PDG SG +D +L
Sbjct: 196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SL 254
Query: 290 RLW 292
R++
Sbjct: 255 RVY 257
Score = 53.5 bits (127), Expect = 3e-07
Identities = 37/124 (29%), Positives = 53/124 (42%), Gaps = 4/124 (3%)
Query: 9 TCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLN 68
T GH + L F PYG F+ S +D L + + GH AV +
Sbjct: 100 TLMGHKANICSLDFH---PYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFS 156
Query: 69 KDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIY 127
D A+AA D T K+WD +G + H V V+F + L +G D+ +R +
Sbjct: 157 PDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
Query: 128 DLNK 131
DL K
Sbjct: 217 DLEK 220
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 72.4 bits (176), Expect = 6e-13
Identities = 70/283 (24%), Positives = 111/283 (39%), Gaps = 37/283 (13%)
Query: 9 TCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGA-TL 67
T GH+ V++L ++ G L SA D + +TG+ + GH V
Sbjct: 104 TLKGHSGAVMELHYN---TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPA 160
Query: 68 NKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIY 127
+ T + D T K+WD + T + + V V F S+ +++GG D ++++
Sbjct: 161 RRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
Query: 128 DLNKPEAEPKEISGHTSGIKKALWCSEDKQILS-ADDKTVRLWDHATMTEVKSLNFNMSV 186
DL + + + GH + SE +LS A D TVR+WD
Sbjct: 221 DLRQNKL-TYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD---------------- 263
Query: 187 SSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDFK 246
+ P+ + I G + +FE + S P+ + AG D
Sbjct: 264 -VRPFAPKERCVKIFQGN------------VHNFE--KNLLRCSWSPDGSKIAAGSADRF 308
Query: 247 LYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTL 289
+Y +D S L GH G I+ V F PD + S S D L
Sbjct: 309 VYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
Score = 55.1 bits (131), Expect = 9e-08
Identities = 43/203 (21%), Positives = 90/203 (44%), Gaps = 4/203 (1%)
Query: 94 LMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCS 153
++ H+ V F + + L + G D+L+ ++++ + GH+ + + + +
Sbjct: 60 MLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNT 119
Query: 154 EDKQILSAD-DKTVRLWDHATMTEVKSLNFNMS-VSSMEYIPEGEILVITYGR--SIAFH 209
+ + SA DKTV +WD T VK L + S V+S G LV T ++
Sbjct: 120 DGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLW 179
Query: 210 SAVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIH 269
I++F+ + + + + + +++GG D + +D + + +GH +
Sbjct: 180 DIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
Query: 270 CVRFSPDGELYASGSEDGTLRLW 292
+ S +G S + D T+R+W
Sbjct: 240 GLSLSSEGSYLLSNAMDNTVRVW 262
Score = 54.7 bits (130), Expect = 1e-07
Identities = 55/257 (21%), Positives = 102/257 (39%), Gaps = 25/257 (9%)
Query: 57 GHKGAVWGATLNKDATKAATAAADFTAKVWDAVSG-DELMTL-AHKHIVKTVDFTQDSNY 114
GH+G V+ + + + A+A D +W+ D TL H V + + D +
Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
Query: 115 LLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQIL--SADDKTVRLWDHA 172
L + DK + ++D E K + GHTS + Q++ +DD TV+LWD
Sbjct: 124 LFSASTDKTVAVWDSETGE-RVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIR 182
Query: 173 TMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPAT------- 225
+++ V ++ + + ++ S + + + ++ + T
Sbjct: 183 KKAAIQTFQNTYQVLAVTFNDTSDQII-----SGGIDNDIKVWDLRQNKLTYTMRGHADS 237
Query: 226 INSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHF-GPIHCVR-------FSPDG 277
+ SL E +L++ D + +D E F G +H +SPDG
Sbjct: 238 VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDG 297
Query: 278 ELYASGSEDGTLRLWQT 294
A+GS D + +W T
Sbjct: 298 SKIAAGSADRFVYVWDT 314
Score = 36.2 bits (82), Expect = 0.045
Identities = 18/68 (26%), Positives = 33/68 (48%), Gaps = 1/68 (1%)
Query: 232 HPEKEFLVAGGEDFKLYKYD-YNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLR 290
HP L + G D + ++ Y + + KGH G + + ++ DG + S S D T+
Sbjct: 75 HPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVA 134
Query: 291 LWQTVVGK 298
+W + G+
Sbjct: 135 VWDSETGE 142
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 72.4 bits (176), Expect = 6e-13
Identities = 75/343 (21%), Positives = 139/343 (40%), Gaps = 58/343 (16%)
Query: 5 QTP-LTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIG-TFLGHKGAV 62
+TP TC GH V+ +++S P G L S CK+G+ +L TG +G T GH +
Sbjct: 146 ETPHFTCKGHRHWVLSISWS---PDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWI 202
Query: 63 WGAT-----LNKDATKAATAAADFTAKVWDAVSGD-ELMTLAHKHIVKTVDFTQDSNYLL 116
G + N + A+++ D + ++WD +G E + H V + + D L
Sbjct: 203 TGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLY 261
Query: 117 TGGQDKLLRI---------------------------YDLNKPEAEPKEISGHTSGIKKA 149
+ QD+ +++ Y L EP E S + ++ +
Sbjct: 262 SASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGS 321
Query: 150 LWCSEDKQ---------------ILSADDKTVRLWDHATMTE--VKSLNFNMSVSSMEYI 192
L +++ + +DD T+ LW A + + ++ + +
Sbjct: 322 LQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFS 381
Query: 193 PEGEILV-ITYGRSIAFHSAVSLDPIKSFEAP-ATINSASLHPEKEFLVAGGEDFKLYKY 250
P+ I+ ++ +SI + + S A + + + LV+G D L +
Sbjct: 382 PDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
Query: 251 DYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQ 293
D + + GH ++ V +SPDG+ ASG +D LR+W+
Sbjct: 442 DVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 58.5 bits (140), Expect = 8e-09
Identities = 67/294 (22%), Positives = 116/294 (39%), Gaps = 52/294 (17%)
Query: 57 GHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYL 115
GH AV + A+ + D T + WD + T H+H V ++ ++ D L
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKL 171
Query: 116 LTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALW-----CSEDKQILSAD-DKTVRLW 169
+G ++ + ++D + + + ++GH+ I W E + + S+ D +VR+W
Sbjct: 172 ASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIW 231
Query: 170 D-HATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAF---HSAVSLDPIK------- 218
D A E SV+ + + +G + + R+I H V ++
Sbjct: 232 DTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVN 291
Query: 219 -------------SFE-APATINSASLHPE-------------------KEFLVAGGEDF 245
+FE A A++N L E LV+G +DF
Sbjct: 292 TMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDF 351
Query: 246 KLYKYD-YNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
L+ + + L GH I+ V FSPD + AS S D +++LW GK
Sbjct: 352 TLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGK 405
Score = 42.0 bits (97), Expect = 8e-04
Identities = 22/74 (29%), Positives = 37/74 (50%)
Query: 228 SASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDG 287
S + P ++L +G D + +D ++ + KGH + + +SPDG ASG ++G
Sbjct: 119 SVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNG 178
Query: 288 TLRLWQTVVGKTYG 301
+ LW GK G
Sbjct: 179 QILLWDPSTGKQVG 192
Score = 34.7 bits (78), Expect = 0.13
Identities = 16/33 (48%), Positives = 20/33 (60%)
Query: 260 SYKGHFGPIHCVRFSPDGELYASGSEDGTLRLW 292
S +GH + V FSP G+ ASGS D T+R W
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFW 141
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 71.6 bits (174), Expect = 1e-12
Identities = 53/243 (21%), Positives = 99/243 (40%), Gaps = 43/243 (17%)
Query: 54 TFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHI-VKTVDFTQDS 112
T GH ++ D+ +A+ D +WD+ + +++ + + V T +
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 113 NYLLTGGQDKLLRIYDLNKPEAE---PKEISGHTSGIKKALWCSEDKQILSADDKTVRLW 169
NY+ GG D + IY+L E +E++GHT + + +++ + S+ D T LW
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW 169
Query: 170 DHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSA 229
D T + + + G+++ S
Sbjct: 170 DIETGQQTTTFTGH----------TGDVM-----------------------------SL 190
Query: 230 SLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTL 289
SL P+ V+G D +D G +++ GH I+ + F P+G +A+GS+D T
Sbjct: 191 SLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATC 250
Query: 290 RLW 292
RL+
Sbjct: 251 RLF 253
Score = 49.7 bits (117), Expect = 4e-06
Identities = 35/127 (27%), Positives = 51/127 (40%), Gaps = 3/127 (2%)
Query: 47 DTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKT 105
+TG TF GH G V +L D + A D +AK+WD G T H+ +
Sbjct: 172 ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINA 231
Query: 106 VDFTQDSNYLLTGGQDKLLRIYDLN-KPEAEPKEISGHTSGIKKALWCSEDKQILSA-DD 163
+ F + N TG D R++DL E GI + + +L+ DD
Sbjct: 232 ICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDD 291
Query: 164 KTVRLWD 170
+WD
Sbjct: 292 FNCNVWD 298
Score = 48.9 bits (115), Expect = 7e-06
Identities = 41/171 (23%), Positives = 75/171 (43%), Gaps = 10/171 (5%)
Query: 5 QTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWG 64
Q T +GHT V+ L+ + P +S D L G TF GH+ +
Sbjct: 175 QQTTTFTGHTGDVMSLS---LAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINA 231
Query: 65 ATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHI---VKTVDFTQDSNYLLTGGQD 121
+ AT + D T +++D + ELMT +H +I + +V F++ LL G D
Sbjct: 232 ICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDD 291
Query: 122 KLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSAD--DKTVRLWD 170
++D K + ++GH + + L ++D ++ D +++W+
Sbjct: 292 FNCNVWDALKAD-RAGVLAGHDNRV-SCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 48.1 bits (113), Expect = 1e-05
Identities = 37/173 (21%), Positives = 72/173 (41%), Gaps = 17/173 (9%)
Query: 137 KEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSLNFNMS-VSSMEYIPE 194
+ + GH + I W ++ + ++SA D + +WD T +V ++ S V + Y P
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 195 GEILVITYGRSIAFHSAVSLDPIKSFEAPATIN----------SASLHPEKEFLVAGGED 244
G Y + S+ +K+ E ++ S + +V D
Sbjct: 109 GN-----YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD 163
Query: 245 FKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVG 297
+D +G++ ++ GH G + + +PD L+ SG+ D + +LW G
Sbjct: 164 TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,543,841
Number of Sequences: 37866
Number of extensions: 679732
Number of successful extensions: 3273
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 213
Number of HSP's successfully gapped in prelim test: 83
Number of HSP's that attempted gapping in prelim test: 1336
Number of HSP's gapped (non-prelim): 1280
length of query: 350
length of database: 18,247,518
effective HSP length: 103
effective length of query: 247
effective length of database: 14,347,320
effective search space: 3543788040
effective search space used: 3543788040
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.