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Search of human proteins with 148612811
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
(1123 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148612811 ubiquitin specific protease 43 [Homo sapiens] 2286 0.0
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens] 716 0.0
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens] 167 4e-41
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens] 167 4e-41
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 159 1e-38
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens] 143 8e-34
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 131 3e-30
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 131 3e-30
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 131 3e-30
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens] 126 1e-28
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 117 8e-26
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 117 8e-26
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 115 2e-25
gi|22550104 ubiquitin specific protease 32 [Homo sapiens] 113 9e-25
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 112 2e-24
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 111 4e-24
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens] 111 4e-24
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens] 111 4e-24
gi|183396780 ubiquitin specific protease 20 [Homo sapiens] 110 1e-23
gi|183397136 ubiquitin specific protease 20 [Homo sapiens] 110 1e-23
gi|183397134 ubiquitin specific protease 20 [Homo sapiens] 110 1e-23
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 103 9e-22
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 103 9e-22
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 102 2e-21
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 100 8e-21
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens] 97 1e-19
gi|45267835 ubiquitin specific protease 50 [Homo sapiens] 86 2e-16
gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens] 79 2e-14
gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens] 79 2e-14
gi|169172880 PREDICTED: Inactive ubiquitin carboxyl-terminal hyd... 73 1e-12
>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
Length = 1123
Score = 2286 bits (5924), Expect = 0.0
Identities = 1123/1123 (100%), Positives = 1123/1123 (100%)
Query: 1 MDLGPGDAAGGGPLAPRPRRRRSLRRLFSRFLLALGSRSRPGDSPPRPQPGHCDGDGEGG 60
MDLGPGDAAGGGPLAPRPRRRRSLRRLFSRFLLALGSRSRPGDSPPRPQPGHCDGDGEGG
Sbjct: 1 MDLGPGDAAGGGPLAPRPRRRRSLRRLFSRFLLALGSRSRPGDSPPRPQPGHCDGDGEGG 60
Query: 61 FACAPGPVPAAPGSPGEERPPGPQPQLQLPAGDGARPPGAQGLKNHGNTCFMNAVVQCLS 120
FACAPGPVPAAPGSPGEERPPGPQPQLQLPAGDGARPPGAQGLKNHGNTCFMNAVVQCLS
Sbjct: 61 FACAPGPVPAAPGSPGEERPPGPQPQLQLPAGDGARPPGAQGLKNHGNTCFMNAVVQCLS 120
Query: 121 NTDLLAEFLALGRYRAAPGRAEVTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQG 180
NTDLLAEFLALGRYRAAPGRAEVTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQG
Sbjct: 121 NTDLLAEFLALGRYRAAPGRAEVTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQG 180
Query: 181 NSQHDALEFLLWLLDRVHEDLEGSSRGPVSEKLPPEATKTSENCLSPSAQLPLGQSFVQS 240
NSQHDALEFLLWLLDRVHEDLEGSSRGPVSEKLPPEATKTSENCLSPSAQLPLGQSFVQS
Sbjct: 181 NSQHDALEFLLWLLDRVHEDLEGSSRGPVSEKLPPEATKTSENCLSPSAQLPLGQSFVQS 240
Query: 241 HFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAV 300
HFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAV
Sbjct: 241 HFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAV 300
Query: 301 PILSTVAALRKMVAEEGGVPADEVILVELYPSGFQRSFFDEEDLNTIAEGDNVYAFQVPP 360
PILSTVAALRKMVAEEGGVPADEVILVELYPSGFQRSFFDEEDLNTIAEGDNVYAFQVPP
Sbjct: 301 PILSTVAALRKMVAEEGGVPADEVILVELYPSGFQRSFFDEEDLNTIAEGDNVYAFQVPP 360
Query: 361 SPSQGTLSAHPLGLSASPRLAAREGQRFSLSLHSESKVLILFCNLVGSGQQASRFGPPFL 420
SPSQGTLSAHPLGLSASPRLAAREGQRFSLSLHSESKVLILFCNLVGSGQQASRFGPPFL
Sbjct: 361 SPSQGTLSAHPLGLSASPRLAAREGQRFSLSLHSESKVLILFCNLVGSGQQASRFGPPFL 420
Query: 421 IREDRAVSWAQLQQSILSKVRHLMKSEAPVQNLGSLFSIRVVGLSVACSYLSPKDSRPLC 480
IREDRAVSWAQLQQSILSKVRHLMKSEAPVQNLGSLFSIRVVGLSVACSYLSPKDSRPLC
Sbjct: 421 IREDRAVSWAQLQQSILSKVRHLMKSEAPVQNLGSLFSIRVVGLSVACSYLSPKDSRPLC 480
Query: 481 HWAVDRVLHLRRPGGPPHVKLAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSC 540
HWAVDRVLHLRRPGGPPHVKLAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSC
Sbjct: 481 HWAVDRVLHLRRPGGPPHVKLAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSC 540
Query: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN
Sbjct: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
Query: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH
Sbjct: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
Query: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKRNSIPPWSASS 720
HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKRNSIPPWSASS
Sbjct: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKRNSIPPWSASS 720
Query: 721 SMRGSTSSSLSDHWLLRLGSHAGSTRGSLLSWSSAPCPSLPQVPDSPIFTNSLCNQEKGG 780
SMRGSTSSSLSDHWLLRLGSHAGSTRGSLLSWSSAPCPSLPQVPDSPIFTNSLCNQEKGG
Sbjct: 721 SMRGSTSSSLSDHWLLRLGSHAGSTRGSLLSWSSAPCPSLPQVPDSPIFTNSLCNQEKGG 780
Query: 781 LEPRRLVRGVKGRSISMKAPTTSRAKQGPFKTMPLRWSFGSKEKPPGASVELVEYLESRR 840
LEPRRLVRGVKGRSISMKAPTTSRAKQGPFKTMPLRWSFGSKEKPPGASVELVEYLESRR
Sbjct: 781 LEPRRLVRGVKGRSISMKAPTTSRAKQGPFKTMPLRWSFGSKEKPPGASVELVEYLESRR 840
Query: 841 RPRSTSQSIVSLLTGTAGEDEKSASPRSNVALPANSEDGGRAIERGPAGVPCPSAQPNHC 900
RPRSTSQSIVSLLTGTAGEDEKSASPRSNVALPANSEDGGRAIERGPAGVPCPSAQPNHC
Sbjct: 841 RPRSTSQSIVSLLTGTAGEDEKSASPRSNVALPANSEDGGRAIERGPAGVPCPSAQPNHC 900
Query: 901 LAPGNSDGPNTARKLKENAGQDIKLPRKFDLPLTVMPSVEHEKPARPEGQKAMNWKESFQ 960
LAPGNSDGPNTARKLKENAGQDIKLPRKFDLPLTVMPSVEHEKPARPEGQKAMNWKESFQ
Sbjct: 901 LAPGNSDGPNTARKLKENAGQDIKLPRKFDLPLTVMPSVEHEKPARPEGQKAMNWKESFQ 960
Query: 961 MGSKSSPPSPYMGFSGNSKDSRRGTSELDRPLQGTLTLLRSVFRKKENRRNERAEVSPQV 1020
MGSKSSPPSPYMGFSGNSKDSRRGTSELDRPLQGTLTLLRSVFRKKENRRNERAEVSPQV
Sbjct: 961 MGSKSSPPSPYMGFSGNSKDSRRGTSELDRPLQGTLTLLRSVFRKKENRRNERAEVSPQV 1020
Query: 1021 PPVSLVSGGLSPAMDGQAPGSPPALRIPEGLARGLGSRLERDVWSAPSSLRLPRKASRAP 1080
PPVSLVSGGLSPAMDGQAPGSPPALRIPEGLARGLGSRLERDVWSAPSSLRLPRKASRAP
Sbjct: 1021 PPVSLVSGGLSPAMDGQAPGSPPALRIPEGLARGLGSRLERDVWSAPSSLRLPRKASRAP 1080
Query: 1081 RGSALGMSQRTVPGEQASYGTFQRVKYHTLSLGRKKTLPESSF 1123
RGSALGMSQRTVPGEQASYGTFQRVKYHTLSLGRKKTLPESSF
Sbjct: 1081 RGSALGMSQRTVPGEQASYGTFQRVKYHTLSLGRKKTLPESSF 1123
>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
Length = 1352
Score = 716 bits (1849), Expect = 0.0
Identities = 399/837 (47%), Positives = 517/837 (61%), Gaps = 59/837 (7%)
Query: 4 GPGDAAGGGPLAPR-PRRRRSLRRLFSRFLLALGSRSRPGDSPPRPQPGHCDGDGEGGFA 62
GPG + P +P P RS+ SR L L + S P G G A
Sbjct: 40 GPGASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGLRSCFPPGPA 99
Query: 63 CAPGPVPAAPGSPGEERPPGPQPQLQLPAGDGARPPGAQGLKNHGNTCFMNAVVQCLSNT 122
AP P P P P P P PA PG GL+NHGNTCFMNA +QCLSNT
Sbjct: 100 AAPTPPPCPPP------PASPAP----PACAAEPVPGVAGLRNHGNTCFMNATLQCLSNT 149
Query: 123 DLLAEFLALGRYRA----------------APGRAEVTEQLAALVRALWTREYTPQLSAE 166
+L AE+LALG+YRA A G+ EVTEQLA LVRALWT EYTPQ S +
Sbjct: 150 ELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQHSRD 209
Query: 167 FKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVSEKLPPEATKTSENCLS 226
FK VSK Q++GNSQHDA EFLLWLLDRVHEDL S V + P SE +
Sbjct: 210 FKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHS----VKQSGQPPLKPPSETDMM 265
Query: 227 PSA-QLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTRFLSVTLV 285
P P+ +FVQ FQAQYRSSLTCPHC KQSNTFDPFLC+SLPIPL TR L VT+V
Sbjct: 266 PEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVV 325
Query: 286 FPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVILVELYPSGFQRSFFDEEDLN 345
+ K +R+G+AVP+ TVA LR+ V+ E +P D+++L E+Y GF RSF D +DL
Sbjct: 326 YQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIPTDQIVLTEMYYDGFHRSFCDTDDLE 385
Query: 346 TIAEGDNVYAFQVPP-SPSQGTLSAHPL----------------GLSASPRLAAREGQRF 388
T+ E D ++AF+ P +G LS + LS+ + AA++G+
Sbjct: 386 TVHESDCIFAFETPEIFRPEGILSQRGIHLNNNLNHLKFGLDYHRLSSPTQTAAKQGKMD 445
Query: 389 S-LSLHSESKVLILFCNLVGSGQQASRFGPPFLIREDRAVSWAQLQQSILSKVRHLMKSE 447
S S K+++L CN +GQQ RFG PF++ ++ ++W LQ+ IL K+++ ++
Sbjct: 446 SPTSRAGSDKIVLLVCNRACTGQQGKRFGLPFVLHLEKTIAWDLLQKEILEKMKYFLRPT 505
Query: 448 APVQNLGSLFSIRVVGLSVACSYLSPKDSRPLCHWAVDRVLHLRRPGGPPHVKLAVEWDS 507
+Q FS+RVV + V +YL P++ +PLCH V+R L PGG HVKL VEWD
Sbjct: 506 VCIQVCP--FSLRVVSV-VGITYLLPQEEQPLCHPIVERALKSCGPGGTAHVKLVVEWDK 562
Query: 508 SVKERLFGSLQEERAQDADSV-WQQQQAHQQHSCTLDECFQFYTKEEQLAQDDAWKCPHC 566
++ LF + ++E DA+SV Q+++ HQ +CTL +CFQ YTKEE+LA DDAW+CPHC
Sbjct: 563 ETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDDAWRCPHC 622
Query: 567 QVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVAQRSTSP 626
+ LQQG + LSLWTLPD+LIIHLKRF Q G+RR KL +VKFPL+GL+M PHV +RS S
Sbjct: 623 KQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHVVKRSQSS 682
Query: 627 EAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQWYSYDD 686
+ W W++P L P D++YDLYAVCNHHG +QGGHYTAYC+NS+DG WY +DD
Sbjct: 683 WSLPSHWSPWRRPYGLGRD-PEDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGLWYCFDD 741
Query: 687 STVEPLREDEVNTRGAYILFYQKRNSIPPWSASSSMRGSTSSSLSDHWLLRLGSHAGSTR 746
S V+ L EDEV T+ AYILFYQ+R +IP WSA+SS+ GSTSSSL +HW+ RL GS
Sbjct: 742 SDVQQLSEDEVCTQTAYILFYQRRTAIPSWSANSSVAGSTSSSLCEHWVSRL---PGSKP 798
Query: 747 GSLLSWSSAPCPSLPQVPDSPIFTNSLCNQEKGGLEPRRLVRGVKGRSISMKAPTTS 803
S+ S +S+ SL + +S T +++ GG R VR V+ +S+S ++ TS
Sbjct: 799 ASVTSAASSRRTSLASLSESVEMTGER-SEDDGGFSTRPFVRSVQRQSLSSRSSVTS 854
Score = 36.2 bits (82), Expect = 0.18
Identities = 79/342 (23%), Positives = 130/342 (38%), Gaps = 44/342 (12%)
Query: 759 SLPQVPDSPIFTNSLCNQEKGGLEPRRLVRGVKGRSISMKAPTTSRAKQGPFKTMPLRWS 818
SL + P+S T KG EP + +R KGR ++ + +S + P +P++ S
Sbjct: 1014 SLAKKPES---TTKRSPSSKGTSEPEKSLR--KGRP-ALASQESSLSSTSPSSPLPVKVS 1067
Query: 819 FG-SKEKPPGASVELVEYLESRRRP----RSTSQSIVSLLTGTAGEDEKSASPRSNVALP 873
S+ + S S P + +S ++ + + +KSAS + A
Sbjct: 1068 LKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASS 1127
Query: 874 ANSEDGGRAIERGPAGVPCPSAQPNHCLAPGNSDGPNTARKLKENAGQDIKLPRKFDLPL 933
+++ R P P S +H L+ S +++ G D +
Sbjct: 1128 TSAKKASGPATRSPFP-PGKSRTSDHSLSREGS---------RQSLGSD-----RASATS 1172
Query: 934 TVMPSVEHEKPARP-EGQKAMNWKESFQMGSKSSPPSPYM-GFSGNSKDSRRGTSELDRP 991
T P+ AR EG+ A S M S SP + G +SK +G
Sbjct: 1173 TSKPNSPRVSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKG------- 1225
Query: 992 LQGTLTLLRSVFRKKENRRN----ERAEVSPQVPPVSLVSGGLSPAMDGQAPG-SPPALR 1046
L+ +S R+KE RR+ + A +S + S+ S + D G PPA +
Sbjct: 1226 ----LSFFKSALRQKETRRSTDLGKTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQ 1281
Query: 1047 IPEGLARGLGSRLERDVWSAPSSLRLPRKASRAPRGSALGMS 1088
P G + +D SA SL RK+ + S + S
Sbjct: 1282 QPNANTTGKEQLVTKDPASAKHSLLSARKSKSSQLDSGVPSS 1323
>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
Length = 963
Score = 167 bits (424), Expect = 4e-41
Identities = 91/235 (38%), Positives = 128/235 (54%), Gaps = 28/235 (11%)
Query: 501 LAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDA 560
LA++WDS + RL+ QE A + Q Q ++ + L +C + +T E L + D
Sbjct: 738 LAMDWDSETR-RLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDP 796
Query: 561 WKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVA 620
W CP+C+ QQ K LW+LP IL++HLKRF R+KL T+V+FP+ GLNM+ V
Sbjct: 797 WYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVC 856
Query: 621 QRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQ 680
S P ++YDL AV NH+G + GHYTAY +N L+G+
Sbjct: 857 NLSARP-----------------------YVYDLIAVSNHYGAMGVGHYTAYAKNKLNGK 893
Query: 681 WYSYDDSTVEPLREDEVNTRGAYILFYQKRN----SIPPWSASSSMRGSTSSSLS 731
WY +DDS V ED++ T+ AY+LFYQ+R+ P S+S S G T S S
Sbjct: 894 WYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSS 948
Score = 148 bits (373), Expect = 3e-35
Identities = 88/280 (31%), Positives = 140/280 (50%), Gaps = 14/280 (5%)
Query: 98 PGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGR-------AEVTEQLAAL 150
PG GL N GNTCFMN+ +QCLSNT L ++ Y A R E+ E A L
Sbjct: 299 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 358
Query: 151 VRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVS 210
++ +W+ FK V ++ QF G Q D+ E L +LLD +HEDL + P
Sbjct: 359 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
Query: 211 EKLP----PEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFL 266
E P+A E + + S + F ++S+L CP C K S TFDPF
Sbjct: 419 ELKDANGRPDAVVAKEAWENHRLR---NDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFC 475
Query: 267 CVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVIL 326
++LP+PL++ R + V LV R + + VP++ V+ L + ++ G+ A+ +++
Sbjct: 476 YLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVV 535
Query: 327 VELYPSGFQRSFFDEEDLNTIAEGDNVYAFQVPPSPSQGT 366
++Y F + F +E LN I D+++ ++V + G+
Sbjct: 536 ADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGS 575
>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
Length = 916
Score = 167 bits (424), Expect = 4e-41
Identities = 91/235 (38%), Positives = 128/235 (54%), Gaps = 28/235 (11%)
Query: 501 LAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDA 560
LA++WDS + RL+ QE A + Q Q ++ + L +C + +T E L + D
Sbjct: 691 LAMDWDSETR-RLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDP 749
Query: 561 WKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVA 620
W CP+C+ QQ K LW+LP IL++HLKRF R+KL T+V+FP+ GLNM+ V
Sbjct: 750 WYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVC 809
Query: 621 QRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQ 680
S P ++YDL AV NH+G + GHYTAY +N L+G+
Sbjct: 810 NLSARP-----------------------YVYDLIAVSNHYGAMGVGHYTAYAKNKLNGK 846
Query: 681 WYSYDDSTVEPLREDEVNTRGAYILFYQKRN----SIPPWSASSSMRGSTSSSLS 731
WY +DDS V ED++ T+ AY+LFYQ+R+ P S+S S G T S S
Sbjct: 847 WYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSS 901
Score = 148 bits (373), Expect = 3e-35
Identities = 88/280 (31%), Positives = 140/280 (50%), Gaps = 14/280 (5%)
Query: 98 PGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGR-------AEVTEQLAAL 150
PG GL N GNTCFMN+ +QCLSNT L ++ Y A R E+ E A L
Sbjct: 252 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 311
Query: 151 VRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVS 210
++ +W+ FK V ++ QF G Q D+ E L +LLD +HEDL + P
Sbjct: 312 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
Query: 211 EKLP----PEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFL 266
E P+A E + + S + F ++S+L CP C K S TFDPF
Sbjct: 372 ELKDANGRPDAVVAKEAWENHRLR---NDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFC 428
Query: 267 CVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVIL 326
++LP+PL++ R + V LV R + + VP++ V+ L + ++ G+ A+ +++
Sbjct: 429 YLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVV 488
Query: 327 VELYPSGFQRSFFDEEDLNTIAEGDNVYAFQVPPSPSQGT 366
++Y F + F +E LN I D+++ ++V + G+
Sbjct: 489 ADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGS 528
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 159 bits (403), Expect = 1e-38
Identities = 90/285 (31%), Positives = 149/285 (52%), Gaps = 12/285 (4%)
Query: 92 GDGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPG-------RAEVT 144
G PG GL N GNTCFMN+ +QCLSNT L E+ +Y+ R E+
Sbjct: 251 GRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIA 310
Query: 145 EQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGS 204
+ A L++ +W+ +++ FK V ++ QF G Q D E L +LLD +HEDL
Sbjct: 311 KSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRI 370
Query: 205 SRGPVSEKLPPEATKTSENCLSPSA---QLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNT 261
+ P + +A + ++ A L S + F ++S+L CP C K S T
Sbjct: 371 RKKPYIQL--KDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVT 428
Query: 262 FDPFLCVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPA 321
FDPF ++LP+P+++ R L V LV + ++ + VP + + L ++ G+PA
Sbjct: 429 FDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPA 488
Query: 322 DEVILVELYPSGFQRSFFDEEDLNTIAEGDNVYAFQVPPSPSQGT 366
D++I+ ++Y F R F +E+L++I E D++Y F++ + ++ T
Sbjct: 489 DKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDT 533
Score = 152 bits (384), Expect = 2e-36
Identities = 77/212 (36%), Positives = 123/212 (58%), Gaps = 25/212 (11%)
Query: 501 LAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDA 560
LA++WD +K+R F E + +SV + + ++ L +C + +T +E+L +D
Sbjct: 720 LALDWDPDLKKRYFDENAAEDFEKHESV--EYKPPKKPFVKLKDCIELFTTKEKLGAEDP 777
Query: 561 WKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVA 620
W CP+C+ QQ KL LW+LP +L++HLKRF R+KL TLV FP++ L+M+ +
Sbjct: 778 WYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFL- 836
Query: 621 QRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQ 680
+P AG Y+L AV NH+G + GGHYTA+ +N DG+
Sbjct: 837 ---INPNAG-------------------PCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGK 874
Query: 681 WYSYDDSTVEPLREDEVNTRGAYILFYQKRNS 712
WY +DDS+V ED++ ++ AY+LFYQ++++
Sbjct: 875 WYYFDDSSVSTASEDQIVSKAAYVLFYQRQDT 906
>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
Length = 963
Score = 143 bits (361), Expect = 8e-34
Identities = 73/211 (34%), Positives = 114/211 (54%), Gaps = 22/211 (10%)
Query: 501 LAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDA 560
+A++W+ +K+R + ++ E D V + + L EC + +T E L +++
Sbjct: 743 IAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMK---KAPVRLQECIELFTTVETLEKENP 799
Query: 561 WKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVA 620
W CP C+ Q KL LW LP+ILIIHLKRF R KL TLV+FP+ L+ + V
Sbjct: 800 WYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVI 859
Query: 621 QRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQ 680
Q S P + YDL AV NH+G ++ GHYT + N GQ
Sbjct: 860 QPQNE-------------------SNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQ 900
Query: 681 WYSYDDSTVEPLREDEVNTRGAYILFYQKRN 711
W+ +DD++V P+ E+++ ++ AY+LFYQ+++
Sbjct: 901 WHYFDDNSVSPVNENQIESKAAYVLFYQRQD 931
Score = 130 bits (326), Expect = 9e-30
Identities = 83/270 (30%), Positives = 135/270 (50%), Gaps = 10/270 (3%)
Query: 98 PGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRY------RAAPG-RAEVTEQLAAL 150
PG GL N GNTCFMN+ +QCLSN L E+ Y R G + E+ E A L
Sbjct: 306 PGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADL 365
Query: 151 VRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVS 210
V+ W+ + + FKN V + SQF G QHD+ E L +LLD +HEDL +
Sbjct: 366 VKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYV 425
Query: 211 EKLPPEATKTSENCLSPSAQ--LPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCV 268
E L A + + + Q S + F ++S+L CP C S TFDPF +
Sbjct: 426 E-LCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYL 484
Query: 269 SLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVILVE 328
S+P+P+ R L V + ++ + L VP ++ L +++ G+ + +++ +
Sbjct: 485 SVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPERMMVAD 544
Query: 329 LYPSGFQRSFFDEEDLNTIAEGDNVYAFQV 358
++ F + + EE L++I + D+++ ++V
Sbjct: 545 VFSHRFYKLYQLEEPLSSILDRDDIFVYEV 574
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 131 bits (330), Expect = 3e-30
Identities = 61/168 (36%), Positives = 96/168 (57%), Gaps = 23/168 (13%)
Query: 540 CTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERR 599
CTL +C + ++KEE+L ++ + C HC+ + + K+ +W LP +L++HLKRF G +
Sbjct: 962 CTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWK 1021
Query: 600 NKLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCN 659
KL T V FPL L+++ +V +GP + K+ Y+L++V N
Sbjct: 1022 QKLQTSVDFPLENLDLSQYV----------IGPKNNLKK-------------YNLFSVSN 1058
Query: 660 HHGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFY 707
H+G L GGHYTAYC+N+ +W+ +DD V + V + AYILFY
Sbjct: 1059 HYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106
Score = 112 bits (280), Expect = 2e-24
Identities = 65/189 (34%), Positives = 101/189 (53%), Gaps = 12/189 (6%)
Query: 94 GARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGRA-------EVTEQ 146
G P GL+N GNTC+MN+++QCL N LA++ Y+ R+ EV E+
Sbjct: 770 GGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEE 829
Query: 147 LAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDL---EG 203
+++ALWT +Y +FK + K QF G SQ D+ E LL+L+D +HEDL +
Sbjct: 830 FGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADN 889
Query: 204 SSRGPVSEKLPPEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFD 263
R + K +E+ Q L +S + + FQ Q++S++ C C K+S TF+
Sbjct: 890 RKRYKEENNDHLDDFKAAEHAWQKHKQ--LNESIIVALFQGQFKSTVQCLTCHKKSRTFE 947
Query: 264 PFLCVSLPI 272
F+ +SLP+
Sbjct: 948 AFMYLSLPL 956
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 131 bits (330), Expect = 3e-30
Identities = 61/168 (36%), Positives = 96/168 (57%), Gaps = 23/168 (13%)
Query: 540 CTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERR 599
CTL +C + ++KEE+L ++ + C HC+ + + K+ +W LP +L++HLKRF G +
Sbjct: 962 CTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWK 1021
Query: 600 NKLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCN 659
KL T V FPL L+++ +V +GP + K+ Y+L++V N
Sbjct: 1022 QKLQTSVDFPLENLDLSQYV----------IGPKNNLKK-------------YNLFSVSN 1058
Query: 660 HHGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFY 707
H+G L GGHYTAYC+N+ +W+ +DD V + V + AYILFY
Sbjct: 1059 HYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106
Score = 112 bits (280), Expect = 2e-24
Identities = 65/189 (34%), Positives = 101/189 (53%), Gaps = 12/189 (6%)
Query: 94 GARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGRA-------EVTEQ 146
G P GL+N GNTC+MN+++QCL N LA++ Y+ R+ EV E+
Sbjct: 770 GGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEE 829
Query: 147 LAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDL---EG 203
+++ALWT +Y +FK + K QF G SQ D+ E LL+L+D +HEDL +
Sbjct: 830 FGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADN 889
Query: 204 SSRGPVSEKLPPEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFD 263
R + K +E+ Q L +S + + FQ Q++S++ C C K+S TF+
Sbjct: 890 RKRYKEENNDHLDDFKAAEHAWQKHKQ--LNESIIVALFQGQFKSTVQCLTCHKKSRTFE 947
Query: 264 PFLCVSLPI 272
F+ +SLP+
Sbjct: 948 AFMYLSLPL 956
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 131 bits (330), Expect = 3e-30
Identities = 61/168 (36%), Positives = 96/168 (57%), Gaps = 23/168 (13%)
Query: 540 CTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERR 599
CTL +C + ++KEE+L ++ + C HC+ + + K+ +W LP +L++HLKRF G +
Sbjct: 962 CTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWK 1021
Query: 600 NKLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCN 659
KL T V FPL L+++ +V +GP + K+ Y+L++V N
Sbjct: 1022 QKLQTSVDFPLENLDLSQYV----------IGPKNNLKK-------------YNLFSVSN 1058
Query: 660 HHGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFY 707
H+G L GGHYTAYC+N+ +W+ +DD V + V + AYILFY
Sbjct: 1059 HYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106
Score = 112 bits (280), Expect = 2e-24
Identities = 65/189 (34%), Positives = 101/189 (53%), Gaps = 12/189 (6%)
Query: 94 GARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGRA-------EVTEQ 146
G P GL+N GNTC+MN+++QCL N LA++ Y+ R+ EV E+
Sbjct: 770 GGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEE 829
Query: 147 LAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDL---EG 203
+++ALWT +Y +FK + K QF G SQ D+ E LL+L+D +HEDL +
Sbjct: 830 FGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADN 889
Query: 204 SSRGPVSEKLPPEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFD 263
R + K +E+ Q L +S + + FQ Q++S++ C C K+S TF+
Sbjct: 890 RKRYKEENNDHLDDFKAAEHAWQKHKQ--LNESIIVALFQGQFKSTVQCLTCHKKSRTFE 947
Query: 264 PFLCVSLPI 272
F+ +SLP+
Sbjct: 948 AFMYLSLPL 956
>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
Length = 1318
Score = 126 bits (316), Expect = 1e-28
Identities = 89/273 (32%), Positives = 135/273 (49%), Gaps = 16/273 (5%)
Query: 98 PGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRA---------APGRAEVTEQLA 148
PG GL N GNTCFMN+V+Q LSNT L +F + A GR + A
Sbjct: 494 PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIG--FA 551
Query: 149 ALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGP 208
L+RALW + ++ K V+ SQF G +QHDA EF+ +LLD +HEDL P
Sbjct: 552 VLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKP 611
Query: 209 VSEKLPPEATKTSENCLSPSAQ--LPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFL 266
+E + + + E + Q SF+ FQ QY+S L CP C K S TFDPFL
Sbjct: 612 YTETVDSDG-RPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFL 670
Query: 267 CVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAV-PILSTVAALRKMVAEEGGVPADEVI 325
+ +P+P +Q + L V + ++ ++V ST + + +++ V + +
Sbjct: 671 YLPVPLPQKQ-KVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLR 729
Query: 326 LVELYPSGFQRSFFDEEDLNTIAEGDNVYAFQV 358
L E+ + F R F L+T++ D + F++
Sbjct: 730 LAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFEL 762
Score = 122 bits (306), Expect = 2e-27
Identities = 75/220 (34%), Positives = 118/220 (53%), Gaps = 30/220 (13%)
Query: 501 LAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDA 560
LA+ W ++ + + F + + + A+ +A + TLD+C +T+ E LA ++A
Sbjct: 1019 LALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEA 1078
Query: 561 WKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFC-QVGERRNKLSTLVKFPLSGLNMAPHV 619
W CP C+ ++ +L LW LP++LI+ LKRF + R+K++ LV+FP+ L+
Sbjct: 1079 WYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLD----- 1133
Query: 620 AQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCR----- 674
L + ++ + LP+ YDLYAV NH+G + GGHYTA R
Sbjct: 1134 ----------LSKFCIGQKEEQLPS-------YDLYAVINHYGGMIGGHYTACARLPNDR 1176
Query: 675 --NSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKRNS 712
D W +DDSTV + E +V TR AY+LFY++RNS
Sbjct: 1177 SSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNS 1216
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 117 bits (292), Expect = 8e-26
Identities = 59/168 (35%), Positives = 92/168 (54%), Gaps = 24/168 (14%)
Query: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
TL +C + +TKE+ L D+ C C+ ++ + K S+ P IL++HLKRF + R +
Sbjct: 245 TLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTS 304
Query: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
KL+T V FPL L++ ++ + +Y+LYAV NH
Sbjct: 305 KLTTFVNFPLRDLDLREFASENTNHA------------------------VYNLYAVSNH 340
Query: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQ 708
G GGHYTAYCR+ G+W++++DS+V P+ +V T AY+LFY+
Sbjct: 341 SGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 388
Score = 100 bits (250), Expect = 6e-21
Identities = 80/233 (34%), Positives = 109/233 (46%), Gaps = 25/233 (10%)
Query: 65 PGPVPAAP--GSPGEERPPGP-QPQLQLP---------AGDGARPPGAQGLKNHGNTCFM 112
P PAAP E RP P P L L A + G GL+N GNTCFM
Sbjct: 10 PEDPPAAPFPALAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFM 69
Query: 113 NAVVQCLSNTDLLAEFLALGRY-----RAAPGRAEVTEQLAALVRALWTREYTPQLS-AE 166
N+++QCLSNT L ++ Y + + E+ A L++ +WT +S +E
Sbjct: 70 NSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSE 129
Query: 167 FKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVS--EKLP--PEATKTSE 222
FK + +Y +F G +Q DA EFL +LLD +H ++ + P S E L P+ K +
Sbjct: 130 FKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQ 189
Query: 223 NCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLR 275
L S + F Q +SSLTC C S FDPF +SLPI R
Sbjct: 190 MW---RKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKR 239
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 117 bits (292), Expect = 8e-26
Identities = 59/168 (35%), Positives = 92/168 (54%), Gaps = 24/168 (14%)
Query: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
TL +C + +TKE+ L D+ C C+ ++ + K S+ P IL++HLKRF + R +
Sbjct: 454 TLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTS 513
Query: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
KL+T V FPL L++ ++ + +Y+LYAV NH
Sbjct: 514 KLTTFVNFPLRDLDLREFASENTNHA------------------------VYNLYAVSNH 549
Query: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQ 708
G GGHYTAYCR+ G+W++++DS+V P+ +V T AY+LFY+
Sbjct: 550 SGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 597
Score = 105 bits (261), Expect = 3e-22
Identities = 75/213 (35%), Positives = 106/213 (49%), Gaps = 17/213 (7%)
Query: 76 GEERPPGPQPQLQLPAGDGARPPGAQGL---KNHGNTCFMNAVVQCLSNTDLLAEFLALG 132
G+ + PGP + P DG AQGL +N GNTCFMN+++QCLSNT L ++
Sbjct: 240 GKGQAPGPS-RSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQR 298
Query: 133 RY-----RAAPGRAEVTEQLAALVRALWTREYTPQLS-AEFKNAVSKYGSQFQGNSQHDA 186
Y + + E+ A L++ +WT +S +EFK + +Y +F G +Q DA
Sbjct: 299 LYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDA 358
Query: 187 LEFLLWLLDRVHEDLEGSSRGPVS--EKLP--PEATKTSENCLSPSAQLPLGQSFVQSHF 242
EFL +LLD +H ++ + P S E L P+ K + L S + F
Sbjct: 359 QEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMW---RKYLEREDSRIGDLF 415
Query: 243 QAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLR 275
Q +SSLTC C S FDPF +SLPI R
Sbjct: 416 VGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKR 448
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 115 bits (288), Expect = 2e-25
Identities = 84/289 (29%), Positives = 133/289 (46%), Gaps = 11/289 (3%)
Query: 99 GAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRY-----RAAP--GRAEVTEQLAALV 151
GA GL N GNTCFMN+ +QC+SNT L ++ GR+ R P + + + LV
Sbjct: 530 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLV 589
Query: 152 RALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVSE 211
+ LW+ + + ++KY +F G Q D+ E L +LLD +HEDL P E
Sbjct: 590 QELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVE 649
Query: 212 KLPPEATKTSENCLSP-SAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSL 270
+ E L +S + F Q RS + C C S FDPF +SL
Sbjct: 650 LKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSL 709
Query: 271 PIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVILVELY 330
P+P+ L +T V +R GL + + L+K + + G+ +++++L E++
Sbjct: 710 PLPMDSYMDLEIT-VIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEVH 768
Query: 331 PSGFQRSFFDEEDLNTIAEGDNVYAFQVP-PSPSQGTLSAHPLGLSASP 378
S + D + + G + AF++P PS S + S+SP
Sbjct: 769 DSNIKNFPQDNQKVQLSVSG-FLCAFEIPVPSSPISASSPTQIDFSSSP 816
Score = 67.4 bits (163), Expect = 7e-11
Identities = 37/108 (34%), Positives = 56/108 (51%), Gaps = 1/108 (0%)
Query: 501 LAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDA 560
+AV+W + + + QE +SV Q ++A Q LD C + +T EE+L + +
Sbjct: 993 IAVDWHPTALHLRYQTSQERVVDKHESVEQSRRA-QAEPINLDSCLRAFTSEEELGESEM 1051
Query: 561 WKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKF 608
+ C C+ KL LW LP LIIHLKRF V ++ K +V+F
Sbjct: 1052 YYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQWIKSQKIVRF 1099
Score = 66.6 bits (161), Expect = 1e-10
Identities = 29/60 (48%), Positives = 42/60 (70%), Gaps = 1/60 (1%)
Query: 651 LYDLYAVCNHHGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKR 710
+Y+LYA+ H G L GGHY Y +N + +WY Y+DS+ E L DE++T AYILFY+++
Sbjct: 1311 IYNLYAISCHSGILSGGHYITYAKNP-NCKWYCYNDSSCEELHPDEIDTDSAYILFYEQQ 1369
>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
Length = 1604
Score = 113 bits (283), Expect = 9e-25
Identities = 84/289 (29%), Positives = 133/289 (46%), Gaps = 18/289 (6%)
Query: 99 GAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRY-----RAAP--GRAEVTEQLAALV 151
GA GL N GNTCFMN+ +QC+SNT L ++ GR+ R P + + + LV
Sbjct: 732 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLV 791
Query: 152 RALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVSE 211
+ LW+ + + ++KY +F G Q D+ E L +LLD +HEDL P E
Sbjct: 792 QELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVE 851
Query: 212 KLPPEATKTSENCLSP-SAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSL 270
+ E L +S V F Q RS + C C S FDPF +SL
Sbjct: 852 LKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSL 911
Query: 271 PIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVILVELY 330
P+P+ L +T V +R GL + + L+K +++ G+ +++++L E++
Sbjct: 912 PLPMDSYMHLEIT-VIKLDGTTPVRYGLRLNMDEKYTGLKKQLSDLCGLNSEQILLAEVH 970
Query: 331 PSGFQRSFFDEEDLNTIAEGDNVYAFQVP--------PSPSQGTLSAHP 371
S + D + + G + AF++P SP+Q S+ P
Sbjct: 971 GSNIKNFPQDNQKVRLSVSG-FLCAFEIPVPVSPISASSPTQTDFSSSP 1018
Score = 77.4 bits (189), Expect = 7e-14
Identities = 43/122 (35%), Positives = 64/122 (52%), Gaps = 1/122 (0%)
Query: 501 LAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDA 560
+AV+WD + + + QE + +SV Q ++A Q LD C + +T EE+L +++
Sbjct: 1195 IAVDWDPTALHLRYQTSQERVVDEHESVEQSRRA-QAEPINLDSCLRAFTSEEELGENEM 1253
Query: 561 WKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVA 620
+ C C+ KL LW LP ILIIHLKRF V R K +VKFP + + +
Sbjct: 1254 YYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAFLV 1313
Query: 621 QR 622
R
Sbjct: 1314 PR 1315
Score = 64.7 bits (156), Expect = 5e-10
Identities = 28/60 (46%), Positives = 42/60 (70%), Gaps = 1/60 (1%)
Query: 651 LYDLYAVCNHHGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKR 710
+Y+LYA+ H G L GGHY Y +N + +WY Y+DS+ + L DE++T AYILFY+++
Sbjct: 1509 IYNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQ 1567
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 112 bits (280), Expect = 2e-24
Identities = 68/198 (34%), Positives = 103/198 (52%), Gaps = 17/198 (8%)
Query: 514 FGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGM 573
F S ERA S + H +L +C Q++T+ E L KC CQ Q+
Sbjct: 525 FDSQNPERADSTVS----RDDHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQEST 580
Query: 574 VKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVAQ-RSTSPEAGLGP 632
+L++ LP + HLKRF VG++R K++T + FPL L+M P +A + + + G P
Sbjct: 581 KQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLE-LDMTPFLASTKESRMKEGQPP 639
Query: 633 WPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPL 692
DC+P + Y L+AV NHHG L+ GHYT++ R D QW+S DD+ +
Sbjct: 640 ------TDCVPN----ENKYSLFAVINHHGTLESGHYTSFIRQQKD-QWFSCDDAIITKA 688
Query: 693 REDEVNTRGAYILFYQKR 710
+++ Y+LFY K+
Sbjct: 689 TIEDLLYSEGYLLFYHKQ 706
Score = 73.2 bits (178), Expect = 1e-12
Identities = 50/178 (28%), Positives = 82/178 (46%), Gaps = 22/178 (12%)
Query: 99 GAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYR---AAPGRAEVTEQLAALVRALW 155
G +GL N GNTCFMN +VQ L++ LL +F +++ +P V E +++L A++
Sbjct: 361 GLRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLCLVCE-MSSLFHAMY 419
Query: 156 TREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVSEKLPP 215
+ TP + + + + + G Q DA EFL+ +LD +H + S G +
Sbjct: 420 SGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRHSKDDSGGQEA----- 474
Query: 216 EATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIP 273
+ NC + + F +S +TC C S T DP +SL +P
Sbjct: 475 ----NNPNCCN---------CIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLP 519
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 111 bits (277), Expect = 4e-24
Identities = 61/169 (36%), Positives = 86/169 (50%), Gaps = 22/169 (13%)
Query: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
TL +C + ++L D+ + C C+ L+ G+ + P+IL IHLKRF
Sbjct: 560 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFST 619
Query: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
K+ST V FPL GL++ P +A+ S P + T YDL +V H
Sbjct: 620 KISTHVSFPLEGLDLQPFLAKDS---------------PAQIVT-------YDLLSVICH 657
Query: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQK 709
HG GHY AYCRN+L+ WY +DD +V + E V AY+LFY+K
Sbjct: 658 HGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 706
Score = 62.8 bits (151), Expect = 2e-09
Identities = 39/112 (34%), Positives = 54/112 (48%), Gaps = 2/112 (1%)
Query: 93 DGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAE-FLALGRYRAAPGRAEVTEQLAALV 151
D R G GLKN GNTC+MNA +Q LSN L + FL G + + + L+
Sbjct: 177 DELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLM 236
Query: 152 RALWTREYTPQ-LSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLE 202
LW + + + F+G SQ DA EFL L+D +HE+L+
Sbjct: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 288
>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
Length = 942
Score = 111 bits (277), Expect = 4e-24
Identities = 61/169 (36%), Positives = 86/169 (50%), Gaps = 22/169 (13%)
Query: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
TL +C + ++L D+ + C C+ L+ G+ + P+IL IHLKRF
Sbjct: 568 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFST 627
Query: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
K+ST V FPL GL++ P +A+ S P + T YDL +V H
Sbjct: 628 KISTHVSFPLEGLDLQPFLAKDS---------------PAQIVT-------YDLLSVICH 665
Query: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQK 709
HG GHY AYCRN+L+ WY +DD +V + E V AY+LFY+K
Sbjct: 666 HGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 714
Score = 62.8 bits (151), Expect = 2e-09
Identities = 39/112 (34%), Positives = 54/112 (48%), Gaps = 2/112 (1%)
Query: 93 DGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAE-FLALGRYRAAPGRAEVTEQLAALV 151
D R G GLKN GNTC+MNA +Q LSN L + FL G + + + L+
Sbjct: 177 DELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLM 236
Query: 152 RALWTREYTPQ-LSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLE 202
LW + + + F+G SQ DA EFL L+D +HE+L+
Sbjct: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 288
>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
Length = 911
Score = 111 bits (277), Expect = 4e-24
Identities = 61/169 (36%), Positives = 86/169 (50%), Gaps = 22/169 (13%)
Query: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
TL +C + ++L D+ + C C+ L+ G+ + P+IL IHLKRF
Sbjct: 537 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFST 596
Query: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
K+ST V FPL GL++ P +A+ S P + T YDL +V H
Sbjct: 597 KISTHVSFPLEGLDLQPFLAKDS---------------PAQIVT-------YDLLSVICH 634
Query: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQK 709
HG GHY AYCRN+L+ WY +DD +V + E V AY+LFY+K
Sbjct: 635 HGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 683
Score = 62.8 bits (151), Expect = 2e-09
Identities = 39/112 (34%), Positives = 54/112 (48%), Gaps = 2/112 (1%)
Query: 93 DGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAE-FLALGRYRAAPGRAEVTEQLAALV 151
D R G GLKN GNTC+MNA +Q LSN L + FL G + + + L+
Sbjct: 146 DELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLM 205
Query: 152 RALWTREYTPQ-LSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLE 202
LW + + + F+G SQ DA EFL L+D +HE+L+
Sbjct: 206 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 257
>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 110 bits (274), Expect = 1e-23
Identities = 58/169 (34%), Positives = 85/169 (50%), Gaps = 22/169 (13%)
Query: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
TL++C + ++L D+ + C C+ L+ G+ + LP+IL IHLKRF
Sbjct: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSF 597
Query: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
K+++ V FPL GL++ P +A+ TS YDL +V H
Sbjct: 598 KINSHVSFPLEGLDLRPFLAKECTSQIT----------------------TYDLLSVICH 635
Query: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQK 709
HG GHY AYC+N ++GQWY +DD V + E V Y+LFY+K
Sbjct: 636 HGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684
Score = 63.2 bits (152), Expect = 1e-09
Identities = 48/173 (27%), Positives = 71/173 (41%), Gaps = 26/173 (15%)
Query: 32 LLALGSRSRPGDSPPRPQPGHCDGDGEGGFACAPGPVPAAPGSPGEERPPGPQPQLQLPA 91
LL S+ DSPP P VP A GE
Sbjct: 100 LLGSSSKFSEQDSPPPSHPLKA--------------VPIAVADEGESESED--------- 136
Query: 92 GDGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAE-FLALGRYRAAPGRAEVTEQLAAL 150
D +P G G+KN GN+C+MNA +Q LSN L + FL G + + + L
Sbjct: 137 -DDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKL 195
Query: 151 VRALWTREYTPQ-LSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLE 202
V +W ++ + + + F+G +Q D EFL L+D++HE+L+
Sbjct: 196 VSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELK 248
>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 110 bits (274), Expect = 1e-23
Identities = 58/169 (34%), Positives = 85/169 (50%), Gaps = 22/169 (13%)
Query: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
TL++C + ++L D+ + C C+ L+ G+ + LP+IL IHLKRF
Sbjct: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSF 597
Query: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
K+++ V FPL GL++ P +A+ TS YDL +V H
Sbjct: 598 KINSHVSFPLEGLDLRPFLAKECTSQIT----------------------TYDLLSVICH 635
Query: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQK 709
HG GHY AYC+N ++GQWY +DD V + E V Y+LFY+K
Sbjct: 636 HGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684
Score = 63.2 bits (152), Expect = 1e-09
Identities = 48/173 (27%), Positives = 71/173 (41%), Gaps = 26/173 (15%)
Query: 32 LLALGSRSRPGDSPPRPQPGHCDGDGEGGFACAPGPVPAAPGSPGEERPPGPQPQLQLPA 91
LL S+ DSPP P VP A GE
Sbjct: 100 LLGSSSKFSEQDSPPPSHPLKA--------------VPIAVADEGESESED--------- 136
Query: 92 GDGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAE-FLALGRYRAAPGRAEVTEQLAAL 150
D +P G G+KN GN+C+MNA +Q LSN L + FL G + + + L
Sbjct: 137 -DDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKL 195
Query: 151 VRALWTREYTPQ-LSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLE 202
V +W ++ + + + F+G +Q D EFL L+D++HE+L+
Sbjct: 196 VSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELK 248
>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 110 bits (274), Expect = 1e-23
Identities = 58/169 (34%), Positives = 85/169 (50%), Gaps = 22/169 (13%)
Query: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
TL++C + ++L D+ + C C+ L+ G+ + LP+IL IHLKRF
Sbjct: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSF 597
Query: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
K+++ V FPL GL++ P +A+ TS YDL +V H
Sbjct: 598 KINSHVSFPLEGLDLRPFLAKECTSQIT----------------------TYDLLSVICH 635
Query: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQK 709
HG GHY AYC+N ++GQWY +DD V + E V Y+LFY+K
Sbjct: 636 HGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684
Score = 63.2 bits (152), Expect = 1e-09
Identities = 48/173 (27%), Positives = 71/173 (41%), Gaps = 26/173 (15%)
Query: 32 LLALGSRSRPGDSPPRPQPGHCDGDGEGGFACAPGPVPAAPGSPGEERPPGPQPQLQLPA 91
LL S+ DSPP P VP A GE
Sbjct: 100 LLGSSSKFSEQDSPPPSHPLKA--------------VPIAVADEGESESED--------- 136
Query: 92 GDGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAE-FLALGRYRAAPGRAEVTEQLAAL 150
D +P G G+KN GN+C+MNA +Q LSN L + FL G + + + L
Sbjct: 137 -DDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKL 195
Query: 151 VRALWTREYTPQ-LSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLE 202
V +W ++ + + + F+G +Q D EFL L+D++HE+L+
Sbjct: 196 VSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELK 248
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 103 bits (257), Expect = 9e-22
Identities = 58/174 (33%), Positives = 86/174 (49%), Gaps = 26/174 (14%)
Query: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
+L +CF +TKEE+L ++A C C+ + KL++ P IL++HL RF
Sbjct: 415 SLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIK 474
Query: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
K S V FPL L++ + ++ SP +Y LYA+CNH
Sbjct: 475 KSSVGVDFPLQRLSLGDFASDKAGSP------------------------VYQLYALCNH 510
Query: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKRNSIP 714
G++ GHYTA CR W+ Y+DS V P+ E++V + Y+LFYQ P
Sbjct: 511 SGSVHYGHYTALCR--CQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPP 562
Score = 91.7 bits (226), Expect = 4e-18
Identities = 69/196 (35%), Positives = 93/196 (47%), Gaps = 21/196 (10%)
Query: 99 GAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYR---AAPGRA-EVTEQLAALVRAL 154
G GL+N GNTCF+NAV+QCLS+T L +F +R GRA E+TE A ++ AL
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGAL 269
Query: 155 WTREYTPQLS-AEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSR------- 206
W + ++ F+ KY F G SQ DA EFL L++R+H ++ R
Sbjct: 270 WHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILA 329
Query: 207 -GPVSEK--------LPPEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLK 257
GPV PE + L L S + F Q +S L C C
Sbjct: 330 NGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGY 389
Query: 258 QSNTFDPFLCVSLPIP 273
+S TF+ F +SLPIP
Sbjct: 390 RSTTFEVFCDLSLPIP 405
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 103 bits (257), Expect = 9e-22
Identities = 58/174 (33%), Positives = 86/174 (49%), Gaps = 26/174 (14%)
Query: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
+L +CF +TKEE+L ++A C C+ + KL++ P IL++HL RF
Sbjct: 415 SLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIK 474
Query: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
K S V FPL L++ + ++ SP +Y LYA+CNH
Sbjct: 475 KSSVGVDFPLQRLSLGDFASDKAGSP------------------------VYQLYALCNH 510
Query: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKRNSIP 714
G++ GHYTA CR W+ Y+DS V P+ E++V + Y+LFYQ P
Sbjct: 511 SGSVHYGHYTALCR--CQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPP 562
Score = 91.7 bits (226), Expect = 4e-18
Identities = 69/196 (35%), Positives = 93/196 (47%), Gaps = 21/196 (10%)
Query: 99 GAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYR---AAPGRA-EVTEQLAALVRAL 154
G GL+N GNTCF+NAV+QCLS+T L +F +R GRA E+TE A ++ AL
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGAL 269
Query: 155 WTREYTPQLS-AEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSR------- 206
W + ++ F+ KY F G SQ DA EFL L++R+H ++ R
Sbjct: 270 WHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILA 329
Query: 207 -GPVSEK--------LPPEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLK 257
GPV PE + L L S + F Q +S L C C
Sbjct: 330 NGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGY 389
Query: 258 QSNTFDPFLCVSLPIP 273
+S TF+ F +SLPIP
Sbjct: 390 RSTTFEVFCDLSLPIP 405
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 102 bits (255), Expect = 2e-21
Identities = 66/188 (35%), Positives = 99/188 (52%), Gaps = 26/188 (13%)
Query: 524 DADSVWQQQQAHQQHS---CTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWT 580
D S ++ +++ Q + C+L +C + +T E+L + + + C C+ Q+ K +
Sbjct: 343 DIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQK 402
Query: 581 LPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPD 640
LP +L +HLKRF RNK+ T V+FPL GL+M ++ + PE
Sbjct: 403 LPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGLDMKCYLLE----PE------------- 445
Query: 641 CLPTSYPLDFLYDLYAVCNHHGNLQG-GHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNT 699
S P LYDL AV HHG+ G GHYTAY + +G+W+ ++DSTV E+ V
Sbjct: 446 ---NSGPESCLYDLAAVVVHHGSGVGSGHYTAYATH--EGRWFHFNDSTVTLTDEETVVK 500
Query: 700 RGAYILFY 707
AYILFY
Sbjct: 501 AKAYILFY 508
Score = 73.6 bits (179), Expect = 1e-12
Identities = 60/194 (30%), Positives = 88/194 (45%), Gaps = 26/194 (13%)
Query: 100 AQGLKNHGNTCFMNAVVQCLSN--------TDLLAEFLALGRYRA---------APGRAE 142
A GL+N GNTCFMNA++Q LSN +L A L G+
Sbjct: 158 ATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVS 217
Query: 143 VTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLE 202
+ E+ + ALW T V K F+G Q DA EF+ +LLD +H +L+
Sbjct: 218 LVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQ 277
Query: 203 GSSRG-PVSEKLPPEATKTSEN--CLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQS 259
G G S L +T ++ N C++ ++ + V + F ++ + C C +S
Sbjct: 278 GGFNGVSRSAILQENSTLSASNKCCINGAS------TVVTAIFGGILQNEVNCLICGTES 331
Query: 260 NTFDPFLCVSLPIP 273
FDPFL +SL IP
Sbjct: 332 RKFDPFLDLSLDIP 345
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 100 bits (249), Expect = 8e-21
Identities = 60/178 (33%), Positives = 89/178 (50%), Gaps = 10/178 (5%)
Query: 533 QAHQQHSCTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRF 592
++H + TL +C + +T+ E L KC C Q+ +L++ LP + HLKRF
Sbjct: 353 ESHVSGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF 412
Query: 593 CQVGERRNKLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLY 652
+ R K++T V FPL L+M P +A S G ++QP S D Y
Sbjct: 413 EHSAKLRRKITTYVSFPLE-LDMTPFMASSKESRMNG-----QYQQP---TDSLNNDNKY 463
Query: 653 DLYAVCNHHGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKR 710
L+AV NH G L+ GHYT++ R D QW+ DD+ + +V Y+LFY K+
Sbjct: 464 SLFAVVNHQGTLESGHYTSFIRQHKD-QWFKCDDAIITKASIKDVLDSEGYLLFYHKQ 520
Score = 79.0 bits (193), Expect = 2e-14
Identities = 55/184 (29%), Positives = 83/184 (45%), Gaps = 22/184 (11%)
Query: 99 GAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRA---APGRAEVTEQLAALVRALW 155
G +GL N GNTCFMN +VQ L++T LL +F R+R +P V E +++L + +
Sbjct: 174 GLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSCLVCE-MSSLFQEFY 232
Query: 156 TREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVSEKLPP 215
+ +P + + + V + G Q DA EFL+ LD +H +G G +
Sbjct: 233 SGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCKGDDNGKKAN---- 288
Query: 216 EATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLR 275
NC+ + F +S +TC C S T DPF +SL +P
Sbjct: 289 --NPNHCNCI------------IDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS 334
Query: 276 QTRF 279
T F
Sbjct: 335 STPF 338
>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
Length = 438
Score = 96.7 bits (239), Expect = 1e-19
Identities = 57/178 (32%), Positives = 88/178 (49%), Gaps = 10/178 (5%)
Query: 533 QAHQQHSCTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRF 592
++H TL +C + +T+ E L KC CQ Q+ +L++ LP + H KRF
Sbjct: 254 ESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRF 313
Query: 593 CQVGERRNKLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLY 652
++R K++T + FPL L+M P +A S G P+ S + Y
Sbjct: 314 EHSAKQRRKITTYISFPLE-LDMTPFMASSKESRMNGQLQLPT--------NSGNNENKY 364
Query: 653 DLYAVCNHHGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKR 710
L+AV NH G L+ GHYT++ R+ D QW+ DD+ + +V Y+LFY K+
Sbjct: 365 SLFAVVNHQGTLESGHYTSFIRHHKD-QWFKCDDAVITKASIKDVLDSEGYLLFYHKQ 421
Score = 75.5 bits (184), Expect = 3e-13
Identities = 53/183 (28%), Positives = 82/183 (44%), Gaps = 20/183 (10%)
Query: 99 GAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGRAE--VTEQLAALVRALWT 156
G +GL N GNTCFMN +VQ L++T +L +F R+R E + ++++L R L++
Sbjct: 76 GLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYS 135
Query: 157 REYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVSEKLPPE 216
+P + + + V + G Q DA EFL+ LD +H +G G +
Sbjct: 136 GNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVG--------K 187
Query: 217 ATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQ 276
A +C + F +S +TC C S T DP +SL +P
Sbjct: 188 AANNPNHC----------NCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSC 237
Query: 277 TRF 279
T F
Sbjct: 238 TSF 240
>gi|45267835 ubiquitin specific protease 50 [Homo sapiens]
Length = 339
Score = 86.3 bits (212), Expect = 2e-16
Identities = 45/141 (31%), Positives = 74/141 (52%), Gaps = 23/141 (16%)
Query: 537 QHSCTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVG 596
++ C+L +C Q + +++ L ++ C C+ Q+ V+ S+ P I+I HLKRF G
Sbjct: 219 KYECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQG 278
Query: 597 ERRNKLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYA 656
+ KL T + +PL+ L++ P++ + YP Y+L A
Sbjct: 279 TTKRKLRTDIHYPLTNLDLTPYICS--------------------IFRKYP---KYNLCA 315
Query: 657 VCNHHGNLQGGHYTAYCRNSL 677
V NH G+L GGHYTA+C+NS+
Sbjct: 316 VVNHFGDLDGGHYTAFCKNSV 336
Score = 68.6 bits (166), Expect = 3e-11
Identities = 57/196 (29%), Positives = 84/196 (42%), Gaps = 15/196 (7%)
Query: 87 LQLPAGDGARP--PGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGR---- 140
L + DG +P G GL N GNTC +NA+ QCL + L E+ G+Y A +
Sbjct: 28 LPVKEADGNQPHFQGVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLP 87
Query: 141 ---AEVTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRV 197
+EV A L+ +W + F +A+ F Q DA EFL+ +L+ +
Sbjct: 88 SDCSEVATAFAYLMTDMWLGDSDCVSPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNEL 147
Query: 198 HEDLEGSSRGPVSEKLPPEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLK 257
HE L+ + S + E T C + S + F+ Q S+ C C K
Sbjct: 148 HEALK---KYHYSRRRSYEKGSTQRCC---RKWITTETSIITQLFEEQLNYSIVCLKCEK 201
Query: 258 QSNTFDPFLCVSLPIP 273
+ + F SLPIP
Sbjct: 202 CTYKNEVFTVFSLPIP 217
>gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]
Length = 712
Score = 79.0 bits (193), Expect = 2e-14
Identities = 62/184 (33%), Positives = 82/184 (44%), Gaps = 33/184 (17%)
Query: 540 CTLDECFQFYTKEEQLAQDDAWKCPHCQ-----------VLQQGMVKLSLWTLPDILIIH 588
C + E +T+ E L + + C C VL + +L + LP +L +H
Sbjct: 515 CLVTEMLAKFTETEAL-EGKIYVCDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLRLH 573
Query: 589 LKRFCQVGER-RNKLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYP 647
LKRF G R K+ V F LNM P+ + + +P+C
Sbjct: 574 LKRFRWSGRNNREKIGVHVGFE-EILNMEPYCCRETLKS----------LRPEC------ 616
Query: 648 LDFLYDLYAVCNHHGNLQG-GHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILF 706
F+YDL AV HHG G GHYTAYC NS G W +DS + DEV AYILF
Sbjct: 617 --FIYDLSAVVMHHGKGFGSGHYTAYCYNSEGGFWVHCNDSKLSMCTMDEVCKAQAYILF 674
Query: 707 YQKR 710
Y +R
Sbjct: 675 YTQR 678
Score = 53.9 bits (128), Expect = 8e-07
Identities = 40/133 (30%), Positives = 63/133 (47%), Gaps = 17/133 (12%)
Query: 146 QLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSS 205
+L L + +W+ ++ ++V + F+G +Q DA EFL LLD++ +L
Sbjct: 384 ELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQREL---- 439
Query: 206 RGPVSEKLPPEATKTSENCLSPSAQLPLGQ---SFVQSHFQAQYRSSLTCPHCLKQSNTF 262
E T TS L P++Q L + + V + F Q S +TC C +SNT
Sbjct: 440 ----------ETTGTSLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTI 489
Query: 263 DPFLCVSLPIPLR 275
+PF +SL P R
Sbjct: 490 EPFWDLSLEFPER 502
Score = 37.7 bits (86), Expect = 0.062
Identities = 15/24 (62%), Positives = 20/24 (83%)
Query: 98 PGAQGLKNHGNTCFMNAVVQCLSN 121
PG GL+N GNTC+MN+V+Q LS+
Sbjct: 270 PGVTGLRNLGNTCYMNSVLQVLSH 293
>gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens]
Length = 712
Score = 79.0 bits (193), Expect = 2e-14
Identities = 62/184 (33%), Positives = 82/184 (44%), Gaps = 33/184 (17%)
Query: 540 CTLDECFQFYTKEEQLAQDDAWKCPHCQ-----------VLQQGMVKLSLWTLPDILIIH 588
C + E +T+ E L + + C C VL + +L + LP +L +H
Sbjct: 515 CLVTEMLAKFTETEAL-EGKIYVCDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLRLH 573
Query: 589 LKRFCQVGER-RNKLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYP 647
LKRF G R K+ V F LNM P+ + + +P+C
Sbjct: 574 LKRFRWSGRNNREKIGVHVGFE-EILNMEPYCCRETLKS----------LRPEC------ 616
Query: 648 LDFLYDLYAVCNHHGNLQG-GHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILF 706
F+YDL AV HHG G GHYTAYC NS G W +DS + DEV AYILF
Sbjct: 617 --FIYDLSAVVMHHGKGFGSGHYTAYCYNSEGGFWVHCNDSKLSMCTMDEVCKAQAYILF 674
Query: 707 YQKR 710
Y +R
Sbjct: 675 YTQR 678
Score = 53.9 bits (128), Expect = 8e-07
Identities = 40/133 (30%), Positives = 63/133 (47%), Gaps = 17/133 (12%)
Query: 146 QLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSS 205
+L L + +W+ ++ ++V + F+G +Q DA EFL LLD++ +L
Sbjct: 384 ELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQREL---- 439
Query: 206 RGPVSEKLPPEATKTSENCLSPSAQLPLGQ---SFVQSHFQAQYRSSLTCPHCLKQSNTF 262
E T TS L P++Q L + + V + F Q S +TC C +SNT
Sbjct: 440 ----------ETTGTSLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTI 489
Query: 263 DPFLCVSLPIPLR 275
+PF +SL P R
Sbjct: 490 EPFWDLSLEFPER 502
Score = 37.7 bits (86), Expect = 0.062
Identities = 15/24 (62%), Positives = 20/24 (83%)
Query: 98 PGAQGLKNHGNTCFMNAVVQCLSN 121
PG GL+N GNTC+MN+V+Q LS+
Sbjct: 270 PGVTGLRNLGNTCYMNSVLQVLSH 293
>gi|169172880 PREDICTED: Inactive ubiquitin carboxyl-terminal
hydrolase 17-like protein 8 [Homo sapiens]
Length = 530
Score = 73.2 bits (178), Expect = 1e-12
Identities = 71/265 (26%), Positives = 120/265 (45%), Gaps = 44/265 (16%)
Query: 537 QHSCTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVG 596
Q + ++ + + K E+L ++A+ C C L+L T +LI+ LKRFC V
Sbjct: 228 QAAQSVKQALEQLVKPEELNGENAYPCGLCLQRAPASNTLTLHTSAKVLILVLKRFCDV- 286
Query: 597 ERRNKLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYA 656
NKL+ V++P L+M P+++Q++T P +Y LYA
Sbjct: 287 -TGNKLAKNVQYP-ECLDMQPYMSQQNTGP-----------------------LVYVLYA 321
Query: 657 VCNHHG-NLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKRNSIPP 715
V H G + G+Y +Y + + +GQWY DD+ V V ++ AY+LFY +++
Sbjct: 322 VLVHAGWSCHNGYYFSYVK-AQEGQWYKMDDAEVTACSITSVLSQQAYVLFYIQKSEWER 380
Query: 716 WSASSSMRGSTSSSLSDHWLLRLGSHAGSTRGSLLSWSSAPCPSLPQVPDSPI------- 768
S S S RG +L + +T+G L PC +P++ + +
Sbjct: 381 HSESVS-RGREPRALGAE-----DTDRPATQGELK--RDHPCLQVPELDEHLVERATEES 432
Query: 769 -FTNSLCNQEKGGLEPRRLVRGVKG 792
+ QE+ ++P VR V+G
Sbjct: 433 TLDHWKFPQEQNKMKPEFNVRKVEG 457
Score = 57.8 bits (138), Expect = 6e-08
Identities = 48/196 (24%), Positives = 80/196 (40%), Gaps = 30/196 (15%)
Query: 85 PQLQLPAGDGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGRAEVT 144
P+ +LP GL+N GNTC++NA +QCL+ T LA ++ + R +
Sbjct: 64 PREKLPLSSRRPAAVGAGLQNMGNTCYLNASLQCLTYTPPLANYMLSREHSQTCQRPKCC 123
Query: 145 EQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGS 204
W ++P + A++ + F Q DA EFL++ +D +
Sbjct: 124 MLCTMQAHITWAL-HSPGHVIQPSQALA---AGFHRGKQEDAHEFLMFTVDAM------- 172
Query: 205 SRGPVSEKLPPEATKTSENCLSPSAQL---PLGQSFVQSHFQAQYRSSLTCPHCLKQSNT 261
+ CL Q+ + + F +RS + C HC S+T
Sbjct: 173 ----------------KKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDT 216
Query: 262 FDPFLCVSLPIPLRQT 277
FDP+L ++L I Q+
Sbjct: 217 FDPYLDIALDIQAAQS 232
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,530,567
Number of Sequences: 37866
Number of extensions: 2997252
Number of successful extensions: 20294
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 499
Number of HSP's that attempted gapping in prelim test: 14653
Number of HSP's gapped (non-prelim): 4185
length of query: 1123
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1010
effective length of database: 13,968,660
effective search space: 14108346600
effective search space used: 14108346600
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.