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Search of human proteins with 10954343
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10954343 ICEBERG caspase-1 inhibitor [Homo sapiens]
(90 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10954343 ICEBERG caspase-1 inhibitor [Homo sapiens] 184 2e-47
gi|62953113 caspase-1 dominant-negative inhibitor pseudo-ICE iso... 102 8e-23
gi|16751833 caspase-1 dominant-negative inhibitor pseudo-ICE iso... 102 8e-23
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 97 2e-21
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 97 2e-21
gi|55925612 caspase recruitment domain family, member 17 [Homo s... 93 4e-20
gi|16554564 caspase recruitment domain family, member 6 [Homo sa... 38 0.001
gi|40788015 caspase recruitment domain protein 12 [Homo sapiens] 35 0.010
gi|7662404 caspase recruitment domain family, member 8 [Homo sap... 33 0.048
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens] 31 0.18
gi|5174617 nucleotide-binding oligomerization domain containing ... 30 0.41
gi|11545912 nucleotide-binding oligomerization domain containing... 30 0.53
gi|19115954 dynein, axonemal, heavy chain 5 [Homo sapiens] 29 0.90
gi|15431334 caspase 1 isoform epsilon [Homo sapiens] 28 1.5
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 27 2.6
gi|15431332 caspase 1 isoform delta [Homo sapiens] 27 2.6
gi|4503031 CASP2 and RIPK1 domain containing adaptor with death ... 27 3.4
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 27 3.4
gi|193788705 schlafen family member 14 [Homo sapiens] 27 3.4
gi|194097442 protein tyrosine phosphatase, receptor type, N poly... 27 4.5
gi|194097440 protein tyrosine phosphatase, receptor type, N poly... 27 4.5
gi|194097438 protein tyrosine phosphatase, receptor type, N poly... 27 4.5
gi|134133246 hypothetical protein LOC285753 [Homo sapiens] 27 4.5
gi|28603844 hypothetical protein LOC285753 [Homo sapiens] 27 4.5
gi|59806361 hypothetical protein LOC387104 [Homo sapiens] 26 7.7
gi|156415992 transcription factor B1, mitochondrial [Homo sapiens] 26 7.7
gi|153791360 ret finger protein-like 4B [Homo sapiens] 26 7.7
gi|38505161 tudor domain containing 1 [Homo sapiens] 25 10.0
gi|126012497 dynein, axonemal, heavy polypeptide 8 [Homo sapiens] 25 10.0
gi|17978485 vacuolar protein sorting 18 [Homo sapiens] 25 10.0
>gi|10954343 ICEBERG caspase-1 inhibitor [Homo sapiens]
Length = 90
Score = 184 bits (466), Expect = 2e-47
Identities = 90/90 (100%), Positives = 90/90 (100%)
Query: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL
Sbjct: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
Query: 61 VTGKGPKSCCKFIKHLCEEDPQLASKMGLH 90
VTGKGPKSCCKFIKHLCEEDPQLASKMGLH
Sbjct: 61 VTGKGPKSCCKFIKHLCEEDPQLASKMGLH 90
>gi|62953113 caspase-1 dominant-negative inhibitor pseudo-ICE
isoform 1 [Homo sapiens]
Length = 197
Score = 102 bits (253), Expect = 8e-23
Identities = 50/89 (56%), Positives = 67/89 (75%)
Query: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
MAD++L++KR++FIHS+G GTIN LLD LL+ V++QE+M KV+ EN TVMDK R LID
Sbjct: 1 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS 60
Query: 61 VTGKGPKSCCKFIKHLCEEDPQLASKMGL 89
V KG ++C I ++CEED LA +GL
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAETLGL 89
>gi|16751833 caspase-1 dominant-negative inhibitor pseudo-ICE
isoform 2 [Homo sapiens]
Length = 97
Score = 102 bits (253), Expect = 8e-23
Identities = 50/89 (56%), Positives = 67/89 (75%)
Query: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
MAD++L++KR++FIHS+G GTIN LLD LL+ V++QE+M KV+ EN TVMDK R LID
Sbjct: 1 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS 60
Query: 61 VTGKGPKSCCKFIKHLCEEDPQLASKMGL 89
V KG ++C I ++CEED LA +GL
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAETLGL 89
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 97.4 bits (241), Expect = 2e-21
Identities = 48/89 (53%), Positives = 66/89 (74%)
Query: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
MAD++L++KR++FI S+G GTIN LLD LL+ V+++E+M KV+ EN TVMDK R LID
Sbjct: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
Query: 61 VTGKGPKSCCKFIKHLCEEDPQLASKMGL 89
V KG ++C I ++CEED LA +GL
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAGTLGL 89
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 97.4 bits (241), Expect = 2e-21
Identities = 48/89 (53%), Positives = 66/89 (74%)
Query: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
MAD++L++KR++FI S+G GTIN LLD LL+ V+++E+M KV+ EN TVMDK R LID
Sbjct: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
Query: 61 VTGKGPKSCCKFIKHLCEEDPQLASKMGL 89
V KG ++C I ++CEED LA +GL
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAGTLGL 89
>gi|55925612 caspase recruitment domain family, member 17 [Homo
sapiens]
Length = 110
Score = 93.2 bits (230), Expect = 4e-20
Identities = 49/89 (55%), Positives = 63/89 (70%)
Query: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
MAD++L++KR+ FI SVG GTIN LL LLE V+SQE++ V+ EN TVMDKAR L+D
Sbjct: 1 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS 60
Query: 61 VTGKGPKSCCKFIKHLCEEDPQLASKMGL 89
V KG +C I ++CEED LA +GL
Sbjct: 61 VIRKGAPACQICITYICEEDSHLAGTLGL 89
>gi|16554564 caspase recruitment domain family, member 6 [Homo
sapiens]
Length = 1037
Score = 38.1 bits (87), Expect = 0.001
Identities = 23/67 (34%), Positives = 38/67 (56%), Gaps = 1/67 (1%)
Query: 23 NALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEEDPQ 82
+++LD L +IS+E+ + + D ++ K+R L+ LV KG +C F+K L PQ
Sbjct: 27 DSILDTLTSRRLISEEEYETLENVTD-LLKKSRKLLILVQKKGEATCQHFLKCLFSTFPQ 85
Query: 83 LASKMGL 89
A+ GL
Sbjct: 86 SAAICGL 92
>gi|40788015 caspase recruitment domain protein 12 [Homo sapiens]
Length = 1024
Score = 35.4 bits (80), Expect = 0.010
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 1/73 (1%)
Query: 6 LRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDLVTGKG 65
++ R I +G I + D L V+++E++N + E D AR +I ++ KG
Sbjct: 4 IKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEK-VEQDAARGIIHMILKKG 62
Query: 66 PKSCCKFIKHLCE 78
+SC F+K L E
Sbjct: 63 SESCNLFLKSLKE 75
>gi|7662404 caspase recruitment domain family, member 8 [Homo
sapiens]
Length = 431
Score = 33.1 bits (74), Expect = 0.048
Identities = 19/66 (28%), Positives = 32/66 (48%), Gaps = 1/66 (1%)
Query: 20 GTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEE 79
G + +LD L ++EV+++ + V E T K L+ +V KG + + + E
Sbjct: 360 GDLKGVLDDLQDNEVLTENEKELVEQEK-TRQSKNEALLSMVEKKGDLALDVLFRSISER 418
Query: 80 DPQLAS 85
DP L S
Sbjct: 419 DPYLVS 424
>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
Length = 377
Score = 31.2 bits (69), Expect = 0.18
Identities = 19/64 (29%), Positives = 33/64 (51%)
Query: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
MA+ RKK + S+G + +LD L+E V++ ++ K + + DK RV+ D
Sbjct: 1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS 60
Query: 61 VTGK 64
+ K
Sbjct: 61 MQEK 64
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 30.0 bits (66), Expect = 0.41
Identities = 23/76 (30%), Positives = 38/76 (50%), Gaps = 4/76 (5%)
Query: 4 QLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDLVTG 63
QLL+ R + + + L+D LL+++ S ED V T DK R ++DLV
Sbjct: 21 QLLKSNRELLVTHIR--NTQCLVDNLLKNDYFSAEDAEIVC-ACPTQPDKVRKILDLVQS 77
Query: 64 KGPKSCCKFIKHLCEE 79
KG + +F +L ++
Sbjct: 78 KG-EEVSEFFLYLLQQ 92
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 29.6 bits (65), Expect = 0.53
Identities = 19/50 (38%), Positives = 25/50 (50%)
Query: 24 ALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFI 73
++LD LL EV+S ED + AR L+D V KG +C K I
Sbjct: 55 SVLDWLLSWEVLSWEDYEGFHLLGQPLSHLARRLLDTVWNKGTWACQKLI 104
Score = 26.9 bits (58), Expect = 3.4
Identities = 18/63 (28%), Positives = 30/63 (47%)
Query: 22 INALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEEDP 81
+ +LD E +SQ + +++R T +AR L+DL T K ++H+ E
Sbjct: 149 VENMLDLAWERGFVSQYECDEIRLPIFTPSQRARRLLDLATVKANGLAAFLLQHVQELPV 208
Query: 82 QLA 84
LA
Sbjct: 209 PLA 211
>gi|19115954 dynein, axonemal, heavy chain 5 [Homo sapiens]
Length = 4624
Score = 28.9 bits (63), Expect = 0.90
Identities = 13/35 (37%), Positives = 23/35 (65%)
Query: 13 FIHSVGAGTINALLDCLLEDEVISQEDMNKVRDEN 47
F S+ +N L++ LL+ EV+S+E+ K+ +EN
Sbjct: 871 FKSSLVEEAVNELVNMLLDVEVLSEEESEKISNEN 905
>gi|15431334 caspase 1 isoform epsilon [Homo sapiens]
Length = 88
Score = 28.1 bits (61), Expect = 1.5
Identities = 10/23 (43%), Positives = 19/23 (82%)
Query: 1 MADQLLRKKRRIFIHSVGAGTIN 23
MAD++L++KR++FI S+G ++
Sbjct: 1 MADKVLKEKRKLFIRSMGEDNVS 23
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 27.3 bits (59), Expect = 2.6
Identities = 10/18 (55%), Positives = 17/18 (94%)
Query: 1 MADQLLRKKRRIFIHSVG 18
MAD++L++KR++FI S+G
Sbjct: 1 MADKVLKEKRKLFIRSMG 18
>gi|15431332 caspase 1 isoform delta [Homo sapiens]
Length = 263
Score = 27.3 bits (59), Expect = 2.6
Identities = 10/18 (55%), Positives = 17/18 (94%)
Query: 1 MADQLLRKKRRIFIHSVG 18
MAD++L++KR++FI S+G
Sbjct: 1 MADKVLKEKRKLFIRSMG 18
>gi|4503031 CASP2 and RIPK1 domain containing adaptor with death
domain [Homo sapiens]
Length = 199
Score = 26.9 bits (58), Expect = 3.4
Identities = 14/63 (22%), Positives = 36/63 (57%), Gaps = 2/63 (3%)
Query: 25 LLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEEDPQLA 84
+L L ++ ++++ + ++ + T + K +L+D++ +GPK+ F+ L +E P +
Sbjct: 26 VLQYLYQEGILTENHIQEINAQT-TGLRKTMLLLDILPSRGPKAFDTFLDSL-QEFPWVR 83
Query: 85 SKM 87
K+
Sbjct: 84 EKL 86
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 26.9 bits (58), Expect = 3.4
Identities = 13/59 (22%), Positives = 32/59 (54%)
Query: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLID 59
MA+ +KK + +G ++ + + L + +V++ ++ K + + + DKA +L+D
Sbjct: 1 MAEDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVD 59
>gi|193788705 schlafen family member 14 [Homo sapiens]
Length = 912
Score = 26.9 bits (58), Expect = 3.4
Identities = 13/66 (19%), Positives = 31/66 (46%)
Query: 21 TINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEED 80
TI + + C LE + +E+M ++++ + M + + T +C + + +CE
Sbjct: 727 TITSGIHCALEIAKVMKEEMKRIKENPPSNMSPDTLALFSETAYEEATCAQALPGVCETK 786
Query: 81 PQLASK 86
L ++
Sbjct: 787 TNLTTE 792
>gi|194097442 protein tyrosine phosphatase, receptor type, N
polypeptide 2 isoform 3 precursor [Homo sapiens]
Length = 986
Score = 26.6 bits (57), Expect = 4.5
Identities = 14/46 (30%), Positives = 24/46 (52%)
Query: 35 ISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEED 80
++ ED+ K +N +++ L L TG G KS KF+ E++
Sbjct: 536 VTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQE 581
>gi|194097440 protein tyrosine phosphatase, receptor type, N
polypeptide 2 isoform 1 precursor [Homo sapiens]
Length = 1015
Score = 26.6 bits (57), Expect = 4.5
Identities = 14/46 (30%), Positives = 24/46 (52%)
Query: 35 ISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEED 80
++ ED+ K +N +++ L L TG G KS KF+ E++
Sbjct: 565 VTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQE 610
>gi|194097438 protein tyrosine phosphatase, receptor type, N
polypeptide 2 isoform 2 precursor [Homo sapiens]
Length = 998
Score = 26.6 bits (57), Expect = 4.5
Identities = 14/46 (30%), Positives = 24/46 (52%)
Query: 35 ISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEED 80
++ ED+ K +N +++ L L TG G KS KF+ E++
Sbjct: 548 VTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQE 593
>gi|134133246 hypothetical protein LOC285753 [Homo sapiens]
Length = 460
Score = 26.6 bits (57), Expect = 4.5
Identities = 15/47 (31%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Query: 4 QLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTV 50
+LL++ + HSV I L+CLL+ I E ++K++ D+V
Sbjct: 343 ELLKQMKETESHSV-CDDIECELECLLKKMEIKGEQISKLKKHQDSV 388
>gi|28603844 hypothetical protein LOC285753 [Homo sapiens]
Length = 460
Score = 26.6 bits (57), Expect = 4.5
Identities = 15/47 (31%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Query: 4 QLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTV 50
+LL++ + HSV I L+CLL+ I E ++K++ D+V
Sbjct: 343 ELLKQMKETESHSV-CDDIECELECLLKKMEIKGEQISKLKKHQDSV 388
>gi|59806361 hypothetical protein LOC387104 [Homo sapiens]
Length = 947
Score = 25.8 bits (55), Expect = 7.7
Identities = 12/33 (36%), Positives = 23/33 (69%), Gaps = 3/33 (9%)
Query: 30 LEDEVISQEDMNKVRDENDTV---MDKARVLID 59
L+++ QE+M K+R+EN+T+ +D+ R +D
Sbjct: 346 LQEQEEMQEEMEKLREENETLKNEIDELRTEMD 378
>gi|156415992 transcription factor B1, mitochondrial [Homo sapiens]
Length = 346
Score = 25.8 bits (55), Expect = 7.7
Identities = 9/17 (52%), Positives = 12/17 (70%)
Query: 67 KSCCKFIKHLCEEDPQL 83
KS C + +C+EDPQL
Sbjct: 301 KSLCDVYRKMCDEDPQL 317
>gi|153791360 ret finger protein-like 4B [Homo sapiens]
Length = 263
Score = 25.8 bits (55), Expect = 7.7
Identities = 19/60 (31%), Positives = 29/60 (48%), Gaps = 3/60 (5%)
Query: 30 LEDEVISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSC-CKFIKHLCEEDPQLASKMG 88
LE + +E++ R+ D +D A LV +S CK I H +DP+LA +G
Sbjct: 80 LEQSLHVREELRHFRE--DVTLDAATASSLLVFSNDLRSAQCKKIHHDLTKDPRLACVLG 137
>gi|38505161 tudor domain containing 1 [Homo sapiens]
Length = 1189
Score = 25.4 bits (54), Expect = 10.0
Identities = 11/39 (28%), Positives = 22/39 (56%)
Query: 38 EDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHL 76
ED+ K+ EN+ V+DK+ ++ ++T C + H+
Sbjct: 465 EDVGKMTTENNIVVDKSDLIPKVLTLNVGDEFCGVVAHI 503
>gi|126012497 dynein, axonemal, heavy polypeptide 8 [Homo sapiens]
Length = 4490
Score = 25.4 bits (54), Expect = 10.0
Identities = 15/68 (22%), Positives = 35/68 (51%), Gaps = 7/68 (10%)
Query: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
++ L K++ + + S+ A D +L + +S + K+++E V DKA+ ++D
Sbjct: 3084 LSQDLAVKEKELAVASIKA-------DEVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDE 3136
Query: 61 VTGKGPKS 68
+ + K+
Sbjct: 3137 IDSEKVKA 3144
>gi|17978485 vacuolar protein sorting 18 [Homo sapiens]
Length = 973
Score = 25.4 bits (54), Expect = 10.0
Identities = 12/33 (36%), Positives = 17/33 (51%)
Query: 6 LRKKRRIFIHSVGAGTINALLDCLLEDEVISQE 38
LR R F +G G + LDC D ++S+E
Sbjct: 277 LRSAPRAFAWMMGDGVLYGALDCGRPDSLLSEE 309
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 3,402,420
Number of Sequences: 37866
Number of extensions: 124293
Number of successful extensions: 319
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 293
Number of HSP's gapped (non-prelim): 32
length of query: 90
length of database: 18,247,518
effective HSP length: 62
effective length of query: 28
effective length of database: 15,899,826
effective search space: 445195128
effective search space used: 445195128
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 54 (25.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.