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Search of human proteins with 14249342
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
(499 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14249342 internexin neuronal intermediate filament protein, a... 939 0.0
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 409 e-114
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 397 e-111
gi|21264345 peripherin [Homo sapiens] 377 e-104
gi|62414289 vimentin [Homo sapiens] 375 e-104
gi|55749932 desmin [Homo sapiens] 369 e-102
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 343 2e-94
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 335 7e-92
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 335 7e-92
gi|4504919 keratin 8 [Homo sapiens] 214 2e-55
gi|67782365 keratin 7 [Homo sapiens] 210 2e-54
gi|153791158 keratin 75 [Homo sapiens] 208 8e-54
gi|119395754 keratin 5 [Homo sapiens] 206 5e-53
gi|4504935 keratin 85 [Homo sapiens] 200 3e-51
gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo sap... 198 8e-51
gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo sap... 198 8e-51
gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo sap... 198 8e-51
gi|14318422 keratin 86 [Homo sapiens] 198 8e-51
gi|169790853 keratin, hair, basic, 1 [Homo sapiens] 197 1e-50
gi|169790841 keratin 83 [Homo sapiens] 197 1e-50
gi|5031839 keratin 6A [Homo sapiens] 197 2e-50
gi|155969697 keratin 6C [Homo sapiens] 197 2e-50
gi|4557701 keratin 17 [Homo sapiens] 196 3e-50
gi|119703753 keratin 6B [Homo sapiens] 195 7e-50
gi|109148552 keratin 3 [Homo sapiens] 194 2e-49
gi|28173564 keratin 73 [Homo sapiens] 194 2e-49
gi|15431316 keratin, hair, basic, 4 [Homo sapiens] 194 2e-49
gi|24430192 keratin 16 [Homo sapiens] 194 2e-49
gi|153791670 keratin 76 [Homo sapiens] 191 1e-48
gi|131412225 keratin 13 isoform a [Homo sapiens] 191 2e-48
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 939 bits (2428), Expect = 0.0
Identities = 499/499 (100%), Positives = 499/499 (100%)
Query: 1 MSFGSEHYLCSSSSYRKVFGDGSRLSARLSGAGGAGGFRSQSLSRSNVASSAACSSASSL 60
MSFGSEHYLCSSSSYRKVFGDGSRLSARLSGAGGAGGFRSQSLSRSNVASSAACSSASSL
Sbjct: 1 MSFGSEHYLCSSSSYRKVFGDGSRLSARLSGAGGAGGFRSQSLSRSNVASSAACSSASSL 60
Query: 61 GLGLAYRRPPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNR 120
GLGLAYRRPPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNR
Sbjct: 61 GLGLAYRRPPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNR 120
Query: 121 ALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRA 180
ALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRA
Sbjct: 121 ALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRA 180
Query: 181 RCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLA 240
RCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLA
Sbjct: 181 RCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLA 240
Query: 241 TLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAAR 300
TLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAAR
Sbjct: 241 TLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAAR 300
Query: 301 STEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQ 360
STEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQ
Sbjct: 301 STEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQ 360
Query: 361 LENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPL 420
LENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPL
Sbjct: 361 LENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPL 420
Query: 421 PNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEEASKVASKKTSQIGESFEEILEETVIS 480
PNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEEASKVASKKTSQIGESFEEILEETVIS
Sbjct: 421 PNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEEASKVASKKTSQIGESFEEILEETVIS 480
Query: 481 TKKTEKSNIEETTISSQKI 499
TKKTEKSNIEETTISSQKI
Sbjct: 481 TKKTEKSNIEETTISSQKI 499
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 409 bits (1052), Expect = e-114
Identities = 240/498 (48%), Positives = 338/498 (67%), Gaps = 26/498 (5%)
Query: 9 LCSSSSYRKVFGDGSRLSARLSGAGGAGGFRSQSLSRSNVASSAACSSASSLGLGLAYRR 68
L + S+YR+V S S R+SG+ +G FRSQS SR + ++ ++ S L LAY
Sbjct: 8 LGNPSAYRRVTETRSSFS-RVSGSPSSG-FRSQSWSRGSPSTVSSSYKRSMLAPRLAYSS 65
Query: 69 P---PASDGLDLSQAAARTN-------EYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQ 118
A LD SQ+++ N +YK+ R+NEKEQLQGLNDRFA +IEKVH LE Q
Sbjct: 66 AMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQ 125
Query: 119 NRALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRL 178
N+ +EAE+ ALRQ+ A +++G+ + +E+R+LRA LE + ++Q L+ D L E++ RL
Sbjct: 126 NKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRL 185
Query: 179 RARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAEL 238
+ R EEE+R R+ E A++A ++D++ A+L +++L+KKV+SL DE+AF+R H+EEVA+L
Sbjct: 186 KERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADL 245
Query: 239 LATLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQA 298
LA +QAS D K D+++AL+EIR+Q ES + +N+ AEEW+K ++A L E A
Sbjct: 246 LAQIQASHITVERKDYL--KTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAA 303
Query: 299 ARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSI 358
++ EAIR+++EEI EYRRQLQ+++IE+E +RG ESLERQ+ ++EERH+ +++ YQD+I
Sbjct: 304 EQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTI 363
Query: 359 GQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLN 418
QLEN+LR TK EMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFST SI+G
Sbjct: 364 QQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITG-- 421
Query: 419 PLPNPSYL-LPPRILSATTSKVSSTGLSLKKE----EEEEEASKVASKKTSQIGESFEEI 473
P Y PP +S+ K LK + EE E +KV +K S++ E+ I
Sbjct: 422 ----PLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEK-SEMEEALTAI 476
Query: 474 LEETVISTKKTEKSNIEE 491
EE +S K+ +K EE
Sbjct: 477 TEELAVSMKEEKKEAAEE 494
Score = 29.6 bits (65), Expect = 6.7
Identities = 16/54 (29%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 448 KEEEEEEASKVASKKTSQIGESFEEILEETVISTKKTE--KSNIEETTISSQKI 499
K EE+ +K K TS+ G+ + + ++V T+K E + EE +S++K+
Sbjct: 847 KSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKV 900
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 397 bits (1021), Expect = e-111
Identities = 237/487 (48%), Positives = 325/487 (66%), Gaps = 26/487 (5%)
Query: 2 SFGSEHYLCSSSSYRKVFGDGSRLSARLSGAGGA-GGFRSQSLSRSNVASSAACSSASSL 60
SF E Y +S R V +S+ SG A + S S S+ S S+SS
Sbjct: 3 SFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSG 62
Query: 61 GLGLAYRRPPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNR 120
L P+ + LDLSQ AA +N+ K IRT EK QLQ LNDRFA FIE+VH+LE QN+
Sbjct: 63 SL------MPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNK 116
Query: 121 ALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRA 180
LEAEL LRQ+H+EPSR L+++E+RDLR E+A++ + ER+GL E ++ L+A
Sbjct: 117 VLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQA 176
Query: 181 RCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLA 240
R EEE RE AE L ++ D A LAR +LEK+++SL+DE++F+++VH+EE+AEL A
Sbjct: 177 RYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQA 236
Query: 241 TLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAAR 300
+Q + Q + E+DVT KPDL++AL++IRAQYE LAAKN+Q+AEEW+KS+F L E AA+
Sbjct: 237 QIQYA-QISVEMDVT--KPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAK 293
Query: 301 STEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQ 360
+T+A+RA+++E+ E RR L+A+T+EIE RG NE+LE+Q+ ELE++ +A+++ QD+I +
Sbjct: 294 NTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINK 353
Query: 361 LENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFS-------TSGLS 413
LEN+LR TKSEMAR+L+EYQDLLNVKMALDIEIAAYRKLLEGEETR S TSG S
Sbjct: 354 LENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYS 413
Query: 414 -------ISGLNPLPNPSYLLPPRIL-SATTSKVSSTGLSLKKEEEEEEASKVASKKTSQ 465
S L SYL+ R S TS V + +++ E +A + + S+
Sbjct: 414 QSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSE 473
Query: 466 IGESFEE 472
GE+ EE
Sbjct: 474 -GEAEEE 479
>gi|21264345 peripherin [Homo sapiens]
Length = 470
Score = 377 bits (969), Expect = e-104
Identities = 217/430 (50%), Positives = 292/430 (67%), Gaps = 22/430 (5%)
Query: 11 SSSSYRKVFGDGSRLSARLSGAGGAGGFRSQS-LSRSNVASSAACSSASSLGLGLAYRRP 69
SS+SYR+ FG LS GA + S S S S + SA+ SS+ LG ++R P
Sbjct: 13 SSTSYRRTFGPPPSLSP------GAFSYSSSSRFSSSRLLGSASPSSSVRLG---SFRSP 63
Query: 70 PASDG---------LDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNR 120
A G LD S A A E+ R+NEK++LQ LNDRFA FIEKV LE QN
Sbjct: 64 RAGAGALLRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNA 123
Query: 121 ALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRA 180
AL EL+ R + EP+R +L Q+ELR+LR +LE R + +ERDGLAE++ L+
Sbjct: 124 ALRGELSQARGQ--EPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQ 181
Query: 181 RCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLA 240
R EEE+R RE AE L ++DVD ATL+RL+LE+K+ESL+DE+ F++++H+EE+ +L
Sbjct: 182 RLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQV 241
Query: 241 TLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAAR 300
++++ EV+ TV KP+LT+ALR+IRAQYES+AAKNLQ AEEWYKSK+A+L++ A R
Sbjct: 242 SVESQQVQQVEVEATV-KPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANR 300
Query: 301 STEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQ 360
+ EA+R +++E++E RRQ+Q+ T E++GLRG NE+L RQ+ ELEE+ + E GYQ +
Sbjct: 301 NHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAAR 360
Query: 361 LENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPL 420
LE +LR K EMARHLREYQ+LLNVKMALDIEIA YRKLLEGEE+R S S + LN
Sbjct: 361 LEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLNIK 420
Query: 421 PNPSYLLPPR 430
+ PP+
Sbjct: 421 TTVPEVEPPQ 430
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 375 bits (964), Expect = e-104
Identities = 214/422 (50%), Positives = 292/422 (69%), Gaps = 20/422 (4%)
Query: 11 SSSSYRKVFGDGSRLSARLSGAG---------GAGGFRSQSLSRSNVASS-----AACSS 56
SSSSYR++FG S S G S SRS ASS A SS
Sbjct: 7 SSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSS 66
Query: 57 ASSLGLGLAYRRPPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLE 116
A L + R D +D S A A E+K RTNEK +LQ LNDRFA +I+KV LE
Sbjct: 67 AVRLRSSVPGVRL-LQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLE 125
Query: 117 TQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQ 176
QN+ L AEL L+ + SR+G+L++ E+R+LR Q+++ ++ +++ +ERD LAE++
Sbjct: 126 QQNKILLAELEQLKGQGK--SRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIM 183
Query: 177 RLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVA 236
RLR + +EE RE AE L++ ++DVD A+LARLDLE+KVESL +E+AF++++H+EE+
Sbjct: 184 RLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQ 243
Query: 237 ELLATLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNE 296
EL A +Q + ++DV V+KPDLT+ALR++R QYES+AAKNLQ AEEWYKSKFA+L+E
Sbjct: 244 ELQAQIQ---EQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSE 300
Query: 297 QAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQD 356
A R+ +A+R +++E EYRRQ+Q+ T E++ L+G NESLERQ+ E+EE + E A YQD
Sbjct: 301 AANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQD 360
Query: 357 SIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISG 416
+IG+L+++++N K EMARHLREYQDLLNVKMALDIEIA YRKLLEGEE+R S + S
Sbjct: 361 TIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSS 420
Query: 417 LN 418
LN
Sbjct: 421 LN 422
>gi|55749932 desmin [Homo sapiens]
Length = 470
Score = 369 bits (948), Expect = e-102
Identities = 210/422 (49%), Positives = 292/422 (69%), Gaps = 22/422 (5%)
Query: 13 SSYRKVFGD------GSRLSARLSGAGGAGGFRSQSLSRSNVASSAACSSASSLGLG--- 63
SSYR+ FG GS LS+ + G G S S S V + S + GLG
Sbjct: 12 SSYRRTFGGAPGFPLGSPLSSPVFPRAGFGSKGSSSSVTSRVYQVSRTSGGAG-GLGSLR 70
Query: 64 ---LAYRRPPASDG----LDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLE 116
L R P+S G LD S A A E+ RTNEK +LQ LNDRFA +IEKV LE
Sbjct: 71 ASRLGTTRTPSSYGAGELLDFSLADAVNQEFLTTRTNEKVELQELNDRFANYIEKVRFLE 130
Query: 117 TQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQ 176
QN AL AE+ L+ R EP+RV EL++ ELR+LR Q+E ++ R++ +ERD L +++Q
Sbjct: 131 QQNAALAAEVNRLKGR--EPTRVAELYEEELRELRRQVEVLTNQRARVDVERDNLLDDLQ 188
Query: 177 RLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVA 236
RL+A+ +EE + +E AE L A + DVD ATLAR+DLE+++ESL +E+AF+++VH+EE+
Sbjct: 189 RLKAKLQEEIQLKEEAENNLAAFRADVDAATLARIDLERRIESLNEEIAFLKKVHEEEIR 248
Query: 237 ELLATLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNE 296
EL A LQ + +V++ ++KPDLT+ALR+IRAQYE++AAKN+ AEEWYKSK ++L +
Sbjct: 249 ELQAQLQ---EQQVQVEMDMSKPDLTAALRDIRAQYETIAAKNISEAEEWYKSKVSDLTQ 305
Query: 297 QAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQD 356
A ++ +A+R +++E+ EYR Q+Q+ T EI+ L+G N+SL RQ+ ELE+R ++E +GYQD
Sbjct: 306 AANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRELEDRFASEASGYQD 365
Query: 357 SIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISG 416
+I +LE ++R+ K EMARHLREYQDLLNVKMALD+EIA YRKLLEGEE+R + + S
Sbjct: 366 NIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESRINLPIQTYSA 425
Query: 417 LN 418
LN
Sbjct: 426 LN 427
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 343 bits (880), Expect = 2e-94
Identities = 215/495 (43%), Positives = 299/495 (60%), Gaps = 24/495 (4%)
Query: 1 MSFGSEHYLCSSSSYRKVFGDGSRLSARLSGAGGAGGFRSQSLSRSNVASSAACSSASSL 60
MSFG L + + + G GS L L+ GGAGG RS + S S S S +S
Sbjct: 2 MSFGGADALLGAP-FAPLHGGGS-LHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVS 59
Query: 61 GLGLAYRRPPASDGLDLSQAAARTNEYKIIRT----NEKEQLQGLNDRFAVFIEKVHQLE 116
+R A+ D + E ++ +EKEQLQ LNDRFA +I+KV QLE
Sbjct: 60 ASPSRFRGAGAASSTDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDRFAGYIDKVRQLE 119
Query: 117 TQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQ 176
NR+LE E AALRQ+ A S +GEL++RE+R++R + +AR Q LE++ L E++
Sbjct: 120 AHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIA 179
Query: 177 RLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVA 236
+R R ++E+R RE AE A +A R A AR+DL+KK ++L +E ++R+ H EEV
Sbjct: 180 HVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVG 239
Query: 237 ELLATLQASSQAAAEVDVTVA---KPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFAN 293
ELL +Q S A A++ K D+TSALREIRAQ E A ++ +EEW++ +
Sbjct: 240 ELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDR 299
Query: 294 LNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAG 353
L+E A +T+A+R+++EEI EYRRQLQART E+E L+ +SLERQ ELE+RH A++A
Sbjct: 300 LSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIAS 359
Query: 354 YQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLS 413
YQ++I QL+ +LRNTK EMA LREYQDLLNVKMALDIEIAAYRKLLEGEE R
Sbjct: 360 YQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRI------ 413
Query: 414 ISGLNPLPNPSYLLP---PRILSATTSKVSSTGLSLKKEEEEEEASKVASKKTSQIGESF 470
G P+P + LP P+I S +T + +K E+ E+ + + ++T + +
Sbjct: 414 --GFGPIP---FSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEET-QVT 467
Query: 471 EEILEETVISTKKTE 485
EE+ EE K+ E
Sbjct: 468 EEVTEEEEKEAKEEE 482
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 335 bits (858), Expect = 7e-92
Identities = 179/356 (50%), Positives = 253/356 (71%), Gaps = 5/356 (1%)
Query: 62 LGLAYRRPPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRA 121
L LA PP +D S A A +K R +E+ ++ LNDRFA +IEKV LE QN+A
Sbjct: 37 LSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKA 96
Query: 122 LEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRAR 181
L AEL LR + EP+++ +++Q ELR+LR +L++ ++ ++ +ERD LA+++ +R +
Sbjct: 97 LAAELNQLRAK--EPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQK 154
Query: 182 CEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLAT 241
++E+ R AE L A +++ D ATLARLDLE+K+ESL +E+ F+R++H+EEV EL
Sbjct: 155 LQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQ 214
Query: 242 LQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARS 301
L A Q E+DV AKPDLT+AL+EIR QYE++A+ N+ AEEWY+SKFA+L + AAR+
Sbjct: 215 L-ARQQVHVELDV--AKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARN 271
Query: 302 TEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQL 361
E +R ++ E ++YRRQLQ+ T ++E LRG NESLERQ+ E EERH E A YQ+++ +L
Sbjct: 272 AELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARL 331
Query: 362 ENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGL 417
E + ++ K EMARHL+EYQDLLNVK+ALDIEIA YRKLLEGEE R + + S L
Sbjct: 332 EEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNL 387
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 335 bits (858), Expect = 7e-92
Identities = 179/356 (50%), Positives = 253/356 (71%), Gaps = 5/356 (1%)
Query: 62 LGLAYRRPPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRA 121
L LA PP +D S A A +K R +E+ ++ LNDRFA +IEKV LE QN+A
Sbjct: 37 LSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKA 96
Query: 122 LEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRAR 181
L AEL LR + EP+++ +++Q ELR+LR +L++ ++ ++ +ERD LA+++ +R +
Sbjct: 97 LAAELNQLRAK--EPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQK 154
Query: 182 CEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLAT 241
++E+ R AE L A +++ D ATLARLDLE+K+ESL +E+ F+R++H+EEV EL
Sbjct: 155 LQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQ 214
Query: 242 LQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARS 301
L A Q E+DV AKPDLT+AL+EIR QYE++A+ N+ AEEWY+SKFA+L + AAR+
Sbjct: 215 L-ARQQVHVELDV--AKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARN 271
Query: 302 TEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQL 361
E +R ++ E ++YRRQLQ+ T ++E LRG NESLERQ+ E EERH E A YQ+++ +L
Sbjct: 272 AELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARL 331
Query: 362 ENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGL 417
E + ++ K EMARHL+EYQDLLNVK+ALDIEIA YRKLLEGEE R + + S L
Sbjct: 332 EEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNL 387
>gi|4504919 keratin 8 [Homo sapiens]
Length = 483
Score = 214 bits (544), Expect = 2e-55
Identities = 145/436 (33%), Positives = 229/436 (52%), Gaps = 21/436 (4%)
Query: 11 SSSSYRKVFGDGSRLSARLSGAGGAGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPP 70
SS SY G GSR+S+ G+ FR AS +A ++ L
Sbjct: 21 SSRSYTS--GPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSL------ 72
Query: 71 ASDGLDLSQAAARTN-EYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAAL 129
LS + + +RT EKEQ++ LN++FA FI+KV LE QN+ LE + + L
Sbjct: 73 ------LSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLL 126
Query: 130 RQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGR 189
+Q+ S + +F+ + +LR QLE + + E + V+ + + E+E R
Sbjct: 127 QQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKR 186
Query: 190 EGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAA 249
E ++DVD A + +++LE ++E L DE+ F+RQ+++EE+ EL + + +S
Sbjct: 187 TEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTS-VV 245
Query: 250 AEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASR 309
+D + + D+ S + E++AQYE +A ++ AE Y+ K+ L A + + +R ++
Sbjct: 246 LSMDNSRSL-DMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTK 304
Query: 310 EEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTK 369
EI E R + EIEGL+G SLE I + E+R + + +LE L+ K
Sbjct: 305 TEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAK 364
Query: 370 SEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPP 429
+MAR LREYQ+L+NVK+ALDIEIA YRKLLEGEE+R SG+ ++ Y
Sbjct: 365 QDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLE-SGMQNMSIHTKTTSGY---A 420
Query: 430 RILSATTSKVSSTGLS 445
LS+ ++S GLS
Sbjct: 421 GGLSSAYGGLTSPGLS 436
>gi|67782365 keratin 7 [Homo sapiens]
Length = 469
Score = 210 bits (535), Expect = 2e-54
Identities = 137/411 (33%), Positives = 217/411 (52%), Gaps = 7/411 (1%)
Query: 5 SEHYLCSSSSYRKVFGDGSRLSARLSGA--GGAGGFRSQSLSRSNVASSAACSSASSLGL 62
S H+ + R G RLS A GG G L S + + +G
Sbjct: 2 SIHFSSPVFTSRSAAFSGRGAQVRLSSARPGGLGSSSLYGLGASRPRVAVRSAYGGPVGA 61
Query: 63 GLAYRRPPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRAL 122
G+ R + L + +R E EQ++ LN++FA FI+KV LE QN+ L
Sbjct: 62 GI--REVTINQSLLAPLRLDADPSLQRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLL 119
Query: 123 EAELAALR-QRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRAR 181
E + L+ Q+ A+ SR+ ++F+ ++ LR QLE + E + + V+ + +
Sbjct: 120 ETKWTLLQEQKSAKSSRLPDIFEAQIAGLRGQLEALQVDGGRLEAELRSMQDVVEDFKNK 179
Query: 182 CEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLAT 241
E+E R AE ++DVD A +++++LE KV++L DE+ F+R +++ E+ EL +
Sbjct: 180 YEDEINHRTAAENEFVVLKKDVDAAYMSKVELEAKVDALNDEINFLRTLNETELTELQSQ 239
Query: 242 LQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARS 301
+ +S +D + + DL + E++AQYE +A + AE WY++KF L QA +
Sbjct: 240 ISDTS-VVLSMDNSRSL-DLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKH 297
Query: 302 TEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQL 361
+ +R +R EI E R +Q EI+ ++ LE I E EER + + +L
Sbjct: 298 GDDLRNTRNEISEMNRAIQRLQAEIDNIKNQRAKLEAAIAEAEERGELALKDARAKQEEL 357
Query: 362 ENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGL 412
E L+ K +MAR LREYQ+L++VK+ALDIEIA YRKLLEGEE+R + G+
Sbjct: 358 EAALQRGKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLAGDGV 408
>gi|153791158 keratin 75 [Homo sapiens]
Length = 551
Score = 208 bits (530), Expect = 8e-54
Identities = 120/326 (36%), Positives = 190/326 (58%), Gaps = 4/326 (1%)
Query: 90 IRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSR--VGELFQREL 147
+R E+EQ++ LN++FA FI+KV LE QN+ LE + A L+++ + R + LF
Sbjct: 145 VRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYT 204
Query: 148 RDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGAT 207
+LR QLE ++ R + E + + V+ + R E+E R AE A ++DVD A
Sbjct: 205 SELRRQLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAY 264
Query: 208 LARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALRE 267
+ +++LE KV+SL +E+ F+ V D E+++L T + +D DL S + E
Sbjct: 265 MNKVELEAKVKSLPEEINFIHSVFDAELSQL-QTQVGDTSVVLSMDNN-RNLDLDSIIAE 322
Query: 268 IRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIE 327
++AQYE +A ++ AE WY++K+ L A R + +R +++EI E R +Q EI+
Sbjct: 323 VKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEID 382
Query: 328 GLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKM 387
++ SL+ I + E+R + + + LE L+ K +MAR LREYQ+L+N+K+
Sbjct: 383 SVKKQCSSLQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKL 442
Query: 388 ALDIEIAAYRKLLEGEETRFSTSGLS 413
ALD+EIA YRKLLEGEE R S G+S
Sbjct: 443 ALDVEIATYRKLLEGEECRLSGEGVS 468
>gi|119395754 keratin 5 [Homo sapiens]
Length = 590
Score = 206 bits (523), Expect = 5e-53
Identities = 136/440 (30%), Positives = 227/440 (51%), Gaps = 27/440 (6%)
Query: 11 SSSSYRKVFGDGSRLSARLSGAGGAG-GFRSQSLSRSNVASSAACSSASSLGLGLAYRRP 69
S S+R FG G+ G G+G GF + + A G G P
Sbjct: 79 SGGSFRNRFGAGAGGGYGFGGGAGSGFGFGGGAGGGFGLGGGAGFGGGFG-GPGFPVCPP 137
Query: 70 PASDGLDLSQAAARTNEYKI------IRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALE 123
+ ++Q+ +I +RT E+EQ++ LN++FA FI+KV LE QN+ L+
Sbjct: 138 GGIQEVTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLD 197
Query: 124 AELAALRQRHAEPSR--VGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRAR 181
+ L+++ + R + LF++ + +LR QL+ R + E + + V+ + +
Sbjct: 198 TKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDFKNK 257
Query: 182 CEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLAT 241
E+E R AE ++DVD A + +++LE KV++L+DE+ F++ D E++++ T
Sbjct: 258 YEDEINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQM-QT 316
Query: 242 LQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARS 301
+ + +D DL S + E++AQYE +A ++ AE WY++K+ L + A R
Sbjct: 317 HVSDTSVVLSMDNN-RNLDLDSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRH 375
Query: 302 TEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQL 361
+ +R ++ EI E R +Q EI+ ++ +L+ I + E+R + ++ + +L
Sbjct: 376 GDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAEL 435
Query: 362 ENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLP 421
E L+ K +MAR LREYQ+L+N K+ALD+EIA YRKLLEGEE R S G+
Sbjct: 436 EEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVG-------- 487
Query: 422 NPSYLLPPRILSATTSKVSS 441
P +S TS VSS
Sbjct: 488 -------PVNISVVTSSVSS 500
>gi|4504935 keratin 85 [Homo sapiens]
Length = 507
Score = 200 bits (508), Expect = 3e-51
Identities = 137/434 (31%), Positives = 219/434 (50%), Gaps = 36/434 (8%)
Query: 13 SSYRKVFGDGSRLSARLSGAG---GAGGFRSQSLSRS-NVASSAACSSASSLGLGLAYRR 68
S YR + G GSR L G GGFR+ S RS S C +
Sbjct: 43 SCYRGLTGFGSRSLCNLGSCGPRIAVGGFRAGSCGRSFGYRSGGVCGPS----------- 91
Query: 69 PPASDGLDLSQAAARTNEYKI------IRTNEKEQLQGLNDRFAVFIEKVHQLETQNRAL 122
PP + ++++ +I ++ EKEQ++ LN RFA FI+KV LE QN+ L
Sbjct: 92 PPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLL 151
Query: 123 EAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRARC 182
E + + + S + LF + LR + E + + E + + E ++ + +
Sbjct: 152 ETKWQFYQNQRCCESNLEPLFSGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKY 211
Query: 183 EEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLATL 242
EEE R AE ++DVD A L + DLE VE+L++E +F+R++++EE+ L A +
Sbjct: 212 EEEVALRATAENEFVVLKKDVDCAYLRKSDLEANVEALVEESSFLRRLYEEEIRVLQAHI 271
Query: 243 QASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARST 302
+S ++D + ++ + EI+AQY+ +A+++ AE WY+SK + R
Sbjct: 272 SDTS-VIVKMDNS-RDLNMDCIIAEIKAQYDDVASRSRAEAESWYRSKCEEMKATVIRHG 329
Query: 303 EAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQLE 362
E +R ++EEI+E R +Q T EIE + LE + E E++ A ++ + + +LE
Sbjct: 330 ETLRRTKEEINELNRMIQRLTAEIENAKCQRAKLEAAVAEAEQQGEAALSDARCKLAELE 389
Query: 363 NDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRF-------------ST 409
L+ K +MA L+EYQ+++N K+ LDIEIA YR+LLEGEE R S
Sbjct: 390 GALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEHRLCEGVGSVNVCVSSSR 449
Query: 410 SGLSISGLNPLPNP 423
G+S GL+ P
Sbjct: 450 GGVSCGGLSYSTTP 463
>gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo
sapiens]
Length = 486
Score = 198 bits (504), Expect = 8e-51
Identities = 131/419 (31%), Positives = 221/419 (52%), Gaps = 10/419 (2%)
Query: 33 GGAGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPPASDGLDLSQAAARTNEYKI--- 89
G GGF S S+ A S S G G+ PP + ++++ +I
Sbjct: 40 GLTGGFGSHSVCGGFRAGSCGRSFGYRSG-GVCGPSPPCITTVSVNESLLTPLNLEIDPN 98
Query: 90 ---IRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRE 146
++ EKEQ++ LN RFA FI+KV LE QN+ LE +L + R S + LF+
Sbjct: 99 AQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGY 158
Query: 147 LRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGA 206
+ LR + E + + E + + E ++ + + EEE R AE A ++DVD A
Sbjct: 159 IETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCA 218
Query: 207 TLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALR 266
L + DLE VE+L+ E+ F+R++++EE+ L + + +S ++D + ++ +
Sbjct: 219 YLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTS-VVVKLDNS-RDLNMDCIIA 276
Query: 267 EIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEI 326
EI+AQY+ + ++ AE WY+SK + R E +R ++EEI+E R +Q T E+
Sbjct: 277 EIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEV 336
Query: 327 EGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVK 386
E + N LE + + E++ A ++ + + +LE L+ K +MA +REYQ+++N K
Sbjct: 337 ENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSK 396
Query: 387 MALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLS 445
+ LDIEIA YR+LLEGEE R G+ + + ++ + ++TT+ V ST +S
Sbjct: 397 LGLDIEIATYRRLLEGEEQRL-CEGVGSVNVCVSSSRGGVVCGDLCASTTAPVVSTRVS 454
>gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo
sapiens]
Length = 486
Score = 198 bits (504), Expect = 8e-51
Identities = 131/419 (31%), Positives = 221/419 (52%), Gaps = 10/419 (2%)
Query: 33 GGAGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPPASDGLDLSQAAARTNEYKI--- 89
G GGF S S+ A S S G G+ PP + ++++ +I
Sbjct: 40 GLTGGFGSHSVCGGFRAGSCGRSFGYRSG-GVCGPSPPCITTVSVNESLLTPLNLEIDPN 98
Query: 90 ---IRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRE 146
++ EKEQ++ LN RFA FI+KV LE QN+ LE +L + R S + LF+
Sbjct: 99 AQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGY 158
Query: 147 LRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGA 206
+ LR + E + + E + + E ++ + + EEE R AE A ++DVD A
Sbjct: 159 IETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCA 218
Query: 207 TLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALR 266
L + DLE VE+L+ E+ F+R++++EE+ L + + +S ++D + ++ +
Sbjct: 219 YLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTS-VVVKLDNS-RDLNMDCIIA 276
Query: 267 EIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEI 326
EI+AQY+ + ++ AE WY+SK + R E +R ++EEI+E R +Q T E+
Sbjct: 277 EIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEV 336
Query: 327 EGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVK 386
E + N LE + + E++ A ++ + + +LE L+ K +MA +REYQ+++N K
Sbjct: 337 ENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSK 396
Query: 387 MALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLS 445
+ LDIEIA YR+LLEGEE R G+ + + ++ + ++TT+ V ST +S
Sbjct: 397 LGLDIEIATYRRLLEGEEQRL-CEGVGSVNVCVSSSRGGVVCGDLCASTTAPVVSTRVS 454
>gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo
sapiens]
Length = 486
Score = 198 bits (504), Expect = 8e-51
Identities = 131/419 (31%), Positives = 221/419 (52%), Gaps = 10/419 (2%)
Query: 33 GGAGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPPASDGLDLSQAAARTNEYKI--- 89
G GGF S S+ A S S G G+ PP + ++++ +I
Sbjct: 40 GLTGGFGSHSVCGGFRAGSCGRSFGYRSG-GVCGPSPPCITTVSVNESLLTPLNLEIDPN 98
Query: 90 ---IRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRE 146
++ EKEQ++ LN RFA FI+KV LE QN+ LE +L + R S + LF+
Sbjct: 99 AQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGY 158
Query: 147 LRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGA 206
+ LR + E + + E + + E ++ + + EEE R AE A ++DVD A
Sbjct: 159 IETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCA 218
Query: 207 TLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALR 266
L + DLE VE+L+ E+ F+R++++EE+ L + + +S ++D + ++ +
Sbjct: 219 YLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTS-VVVKLDNS-RDLNMDCIIA 276
Query: 267 EIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEI 326
EI+AQY+ + ++ AE WY+SK + R E +R ++EEI+E R +Q T E+
Sbjct: 277 EIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEV 336
Query: 327 EGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVK 386
E + N LE + + E++ A ++ + + +LE L+ K +MA +REYQ+++N K
Sbjct: 337 ENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSK 396
Query: 387 MALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLS 445
+ LDIEIA YR+LLEGEE R G+ + + ++ + ++TT+ V ST +S
Sbjct: 397 LGLDIEIATYRRLLEGEEQRL-CEGVGSVNVCVSSSRGGVVCGDLCASTTAPVVSTRVS 454
>gi|14318422 keratin 86 [Homo sapiens]
Length = 486
Score = 198 bits (504), Expect = 8e-51
Identities = 131/419 (31%), Positives = 221/419 (52%), Gaps = 10/419 (2%)
Query: 33 GGAGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPPASDGLDLSQAAARTNEYKI--- 89
G GGF S S+ A S S G G+ PP + ++++ +I
Sbjct: 40 GLTGGFGSHSVCGGFRAGSCGRSFGYRSG-GVCGPSPPCITTVSVNESLLTPLNLEIDPN 98
Query: 90 ---IRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRE 146
++ EKEQ++ LN RFA FI+KV LE QN+ LE +L + R S + LF+
Sbjct: 99 AQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGY 158
Query: 147 LRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGA 206
+ LR + E + + E + + E ++ + + EEE R AE A ++DVD A
Sbjct: 159 IETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCA 218
Query: 207 TLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALR 266
L + DLE VE+L+ E+ F+R++++EE+ L + + +S ++D + ++ +
Sbjct: 219 YLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTS-VVVKLDNS-RDLNMDCIIA 276
Query: 267 EIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEI 326
EI+AQY+ + ++ AE WY+SK + R E +R ++EEI+E R +Q T E+
Sbjct: 277 EIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEV 336
Query: 327 EGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVK 386
E + N LE + + E++ A ++ + + +LE L+ K +MA +REYQ+++N K
Sbjct: 337 ENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSK 396
Query: 387 MALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLS 445
+ LDIEIA YR+LLEGEE R G+ + + ++ + ++TT+ V ST +S
Sbjct: 397 LGLDIEIATYRRLLEGEEQRL-CEGVGSVNVCVSSSRGGVVCGDLCASTTAPVVSTRVS 454
>gi|169790853 keratin, hair, basic, 1 [Homo sapiens]
Length = 505
Score = 197 bits (502), Expect = 1e-50
Identities = 124/380 (32%), Positives = 204/380 (53%), Gaps = 9/380 (2%)
Query: 33 GGAGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPPASDGLDLSQAAARTNEYKI--- 89
G GGF S S+ A S S G G+ PP + ++++ +I
Sbjct: 40 GLTGGFGSHSVCGGFRAGSCGRSFGYRSG-GVCGPSPPCITTVSVNESLLTPLNLEIDPN 98
Query: 90 ---IRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRE 146
++ EKEQ++ LN RFA FI+KV LE QN+ LE +L + R S + LF+
Sbjct: 99 AQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGY 158
Query: 147 LRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGA 206
+ LR + E + + E + + E ++ + + EEE R AE A ++DVD A
Sbjct: 159 IETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCA 218
Query: 207 TLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALR 266
L + DLE VE+L+ E+ F+R++++EE+ L + + +S ++D + ++ +
Sbjct: 219 YLRKSDLEANVEALIQEIDFLRRLYEEEILILQSHISDTS-VVVKLDNS-RDLNMDCIIA 276
Query: 267 EIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEI 326
EI+AQY+ + ++ AE WY+SK + R E +R ++EEI+E R +Q T E+
Sbjct: 277 EIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEV 336
Query: 327 EGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVK 386
E + N LE + + E++ A ++ + + +LE L+ K +MA +REYQ+++N K
Sbjct: 337 ENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSK 396
Query: 387 MALDIEIAAYRKLLEGEETR 406
+ LDIEIA YR+LLEGEE R
Sbjct: 397 LGLDIEIATYRRLLEGEEQR 416
>gi|169790841 keratin 83 [Homo sapiens]
Length = 493
Score = 197 bits (502), Expect = 1e-50
Identities = 125/380 (32%), Positives = 204/380 (53%), Gaps = 9/380 (2%)
Query: 33 GGAGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPPASDGLDLSQAAARTNEYKI--- 89
G GGF S S+ A S S G G+ PP + ++++ +I
Sbjct: 45 GLTGGFGSHSVCGGFRAGSCGRSFGYRSG-GVCGPSPPCITTVSVNESLLTPLNLEIDPN 103
Query: 90 ---IRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRE 146
++ EKEQ++ LN RFA FI+KV LE QN+ LE +L + R S + LF
Sbjct: 104 AQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFAGY 163
Query: 147 LRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGA 206
+ LR + E + + E + + E ++ + + EEE R AE A ++DVD A
Sbjct: 164 IETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVALKKDVDCA 223
Query: 207 TLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALR 266
L + DLE VE+L+ E+ F+R++++EE+ L + + +S ++D + ++ +
Sbjct: 224 YLRKSDLEANVEALIQEIDFLRRLYEEEIRILQSHISDTS-VVVKLDNS-RDLNMDCIVA 281
Query: 267 EIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEI 326
EI+AQY+ +A ++ AE WY+SK + R E +R ++EEI+E R +Q T E+
Sbjct: 282 EIKAQYDDIATRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEV 341
Query: 327 EGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVK 386
E + N LE + + E++ A ++ + + +LE L+ K +MA +REYQ+++N K
Sbjct: 342 ENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSK 401
Query: 387 MALDIEIAAYRKLLEGEETR 406
+ LDIEIA YR+LLEGEE R
Sbjct: 402 LGLDIEIATYRRLLEGEEQR 421
>gi|5031839 keratin 6A [Homo sapiens]
Length = 564
Score = 197 bits (501), Expect = 2e-50
Identities = 110/325 (33%), Positives = 193/325 (59%), Gaps = 4/325 (1%)
Query: 90 IRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSR--VGELFQREL 147
+R E+EQ++ LN++FA FI+KV LE QN+ LE + L+++ + R + LF++ +
Sbjct: 159 VRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYI 218
Query: 148 RDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGAT 207
+LR QL+ R + E G+ + V+ + + E+E R AE ++DVD A
Sbjct: 219 NNLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTLKKDVDAAY 278
Query: 208 LARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALRE 267
+ +++L+ K ++L DE+ F+R ++D E++++ + +S +D DL S + E
Sbjct: 279 MNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTS-VVLSMDNN-RNLDLDSIIAE 336
Query: 268 IRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIE 327
++AQYE +A ++ AE WY++K+ L A R + +R +++EI E R +Q EI+
Sbjct: 337 VKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEID 396
Query: 328 GLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKM 387
++ +L+ I + E+R + ++ + LE+ L+ K ++AR L+EYQ+L+NVK+
Sbjct: 397 HVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKL 456
Query: 388 ALDIEIAAYRKLLEGEETRFSTSGL 412
ALD+EIA YRKLLEGEE R + G+
Sbjct: 457 ALDVEIATYRKLLEGEECRLNGEGV 481
>gi|155969697 keratin 6C [Homo sapiens]
Length = 564
Score = 197 bits (500), Expect = 2e-50
Identities = 125/397 (31%), Positives = 213/397 (53%), Gaps = 20/397 (5%)
Query: 19 FGDGSRLSARLSGAGG-AGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPPASDGLDL 77
FG G+ + L G G AGGF + SL L + PA
Sbjct: 102 FGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPA------ 155
Query: 78 SQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPS 137
+ +R E+EQ++ LN++FA FI+KV LE QN+ L+ + L+++ +
Sbjct: 156 ---------IQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTV 206
Query: 138 R--VGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERA 195
R + LF++ + +LR QL+ R + E + + V+ L+ + E+E R AE
Sbjct: 207 RQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENE 266
Query: 196 LKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVT 255
++DVD A + +++L+ K ++L DE+ F+R ++D E++++ + +S +D
Sbjct: 267 FVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTS-VVLSMDNN 325
Query: 256 VAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEY 315
DL S + E++AQYE +A ++ AE WY++K+ L A R + +R +++EI E
Sbjct: 326 -RNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEI 384
Query: 316 RRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARH 375
R +Q EI+ ++ SL+ I + E+R + ++ + LE+ L+ K ++AR
Sbjct: 385 NRMIQRLRSEIDHVKKQCASLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARL 444
Query: 376 LREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGL 412
L+EYQ+L+NVK+ALD+EIA YRKLLEGEE R + G+
Sbjct: 445 LKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGV 481
>gi|4557701 keratin 17 [Homo sapiens]
Length = 432
Score = 196 bits (499), Expect = 3e-50
Identities = 132/391 (33%), Positives = 202/391 (51%), Gaps = 18/391 (4%)
Query: 20 GDGSRLSARLSGAGGAGGFRSQSLSR-SNVASSAACSSASSLGLGLAYRRPPASDGLDLS 78
G SR S RLSG GAG R S + ++ SS S G G Y + G+D
Sbjct: 22 GGSSRTSCRLSGGLGAGSCRLGSAGGLGSTLGGSSYSSCYSFGSGGGYGS--SFGGVD-- 77
Query: 79 QAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAE-PS 137
++ EK +Q LNDR A +++KV LE N LE ++ QR A P+
Sbjct: 78 ---------GLLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQRQAPGPA 128
Query: 138 RVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALK 197
R + R + +L+ ++ A+ + LL+ D R + E E R E +
Sbjct: 129 RDYSQYYRTIEELQNKILTATVDNANILLQIDNARLAADDFRTKFETEQALRLSVEADIN 188
Query: 198 AQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVA 257
+R +D TLAR DLE ++E+L +ELA++++ H+EE+ L Q + E+D
Sbjct: 189 GLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRG--QVGGEINVEMDAAPG 246
Query: 258 KPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRR 317
DL+ L E+R QYE +A KN + AE+W+ SK LN + A ++E +++ + EI E RR
Sbjct: 247 V-DLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRR 305
Query: 318 QLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLR 377
+QA IE++ SLE + E E R+ +++ Q IG +E L + EM + +
Sbjct: 306 TMQALEIELQSQLSMKASLEGNLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQ 365
Query: 378 EYQDLLNVKMALDIEIAAYRKLLEGEETRFS 408
EY+ LL+VK L+ EIA YR+LLEGE+ +
Sbjct: 366 EYKILLDVKTRLEQEIATYRRLLEGEDAHLT 396
>gi|119703753 keratin 6B [Homo sapiens]
Length = 564
Score = 195 bits (496), Expect = 7e-50
Identities = 124/397 (31%), Positives = 213/397 (53%), Gaps = 20/397 (5%)
Query: 19 FGDGSRLSARLSGAGG-AGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPPASDGLDL 77
FG G+ + L G G AGGF + SL L + PA
Sbjct: 102 FGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPA------ 155
Query: 78 SQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPS 137
+ +R E+EQ++ LN++FA FI+KV LE QN+ L+ + L+++ +
Sbjct: 156 ---------IQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTV 206
Query: 138 R--VGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERA 195
R + LF++ + +LR QL+ R + E + + V+ L+ + E+E R AE
Sbjct: 207 RQNLEPLFEQYINNLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENE 266
Query: 196 LKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVT 255
++DVD A + +++L+ K ++L DE+ F+R ++D E++++ + +S +D
Sbjct: 267 FVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTS-VVLSMDNN 325
Query: 256 VAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEY 315
DL S + E++AQYE +A ++ AE WY++K+ L A R + +R +++EI E
Sbjct: 326 -RNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEIAEI 384
Query: 316 RRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARH 375
R +Q EI+ ++ +L+ I + E+R + ++ + LE+ L+ K ++AR
Sbjct: 385 NRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARL 444
Query: 376 LREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGL 412
L+EYQ+L+NVK+ALD+EIA YRKLLEGEE R + G+
Sbjct: 445 LKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGV 481
>gi|109148552 keratin 3 [Homo sapiens]
Length = 628
Score = 194 bits (493), Expect = 2e-49
Identities = 132/418 (31%), Positives = 218/418 (52%), Gaps = 23/418 (5%)
Query: 19 FGDGSRLSARLSGAGG---AGGFRSQSL--SRSNVASSAACSSASSLGLGLAYRR---PP 70
FG G + GAGG AGGF S SLG + P
Sbjct: 109 FGGGRGMGGGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPG 168
Query: 71 ASDGLDLSQAAARTNEYKI------IRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEA 124
+ ++Q+ + +I ++ E+EQ++ LN++FA FI+KV LE QN+ LE
Sbjct: 169 GIQEVTINQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLET 228
Query: 125 ELAALRQRHAEP----SRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRA 180
+ L+Q+ + + LF+ + LR+ L+ R + E + + V+ +
Sbjct: 229 KWNLLQQQGTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKK 288
Query: 181 RCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLA 240
+ E+E R AE ++DVD A + +++L+ KV++L+DE+ F+R ++D E++++ +
Sbjct: 289 KYEDEINKRTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQS 348
Query: 241 TLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAAR 300
+ +S +D + DL S + E+RAQYE +A ++ AE Y++K L A R
Sbjct: 349 HISDTS-VVLSMDNNRSL-DLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGR 406
Query: 301 STEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQ 360
+ +R ++ EI E R +Q EIEG++ N +L+ I E E+ + + +
Sbjct: 407 HGDDLRNTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQE 466
Query: 361 LENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFS---TSGLSIS 415
L+ L+ K ++AR LR+YQ+L+NVK+ALD+EIA YRKLLEGEE R S S +SIS
Sbjct: 467 LQAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSIS 524
>gi|28173564 keratin 73 [Homo sapiens]
Length = 540
Score = 194 bits (492), Expect = 2e-49
Identities = 146/439 (33%), Positives = 225/439 (51%), Gaps = 40/439 (9%)
Query: 18 VFGDGSRLSARLSGAGGAGGFRSQSL-----SRS---NVASSAACSSASSLGLGLAYRRP 69
V GS S R G G +GGF S+SL +RS NVAS + + G G A
Sbjct: 23 VLSGGSSSSYRAGGKGLSGGFSSRSLYSLGGARSISFNVASGSGWAGGYGFGRGRASGFA 82
Query: 70 PASDGL--------------DLSQAAARTN-----------EYKIIRTNEKEQLQGLNDR 104
+ G + Q + E + +R E+EQ++ LN++
Sbjct: 83 GSMFGSVALGSVCPSLCPPGGIHQVTINKSLLAPLNVELDPEIQKVRAQEREQIKVLNNK 142
Query: 105 FAVFIEKVHQLETQNRALEAELAALRQRHAE--PSRVGELFQRELRDLRAQLEEASSARS 162
FA FI+KV LE QN+ LE + L+Q + + + + + +LR QLE S R
Sbjct: 143 FASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRV 202
Query: 163 QALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLD 222
+ E + E V+ + R EEE R AE ++DVD A ++++L+ KV++L
Sbjct: 203 RLDSELRSVREVVEDYKKRYEEEINKRTTAENEFVVLKKDVDAAYTSKVELQAKVDALDG 262
Query: 223 ELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQS 282
E+ F + +++ E A++ + + +S +D DL S + E+RAQYE +A K+
Sbjct: 263 EIKFFKCLYEGETAQIQSHISDTS-IILSMDNN-RNLDLDSIIAEVRAQYEEIARKSKAE 320
Query: 283 AEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILE 342
AE Y++KF L A R + ++ ++ EI E R +Q EIE ++ +LE I +
Sbjct: 321 AEALYQTKFQELQLAAGRHGDDLKHTKNEISELTRLIQRLRSEIESVKKQCANLETAIAD 380
Query: 343 LEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEG 402
E+R + + + +LE L+ K E+AR LREYQ+LL+VK++LDIEIA YRKLLEG
Sbjct: 381 AEQRGDCALKDARAKLDELEGALQQAKEELARMLREYQELLSVKLSLDIEIATYRKLLEG 440
Query: 403 EETRFS---TSGLSISGLN 418
EE R S T+ +SIS +N
Sbjct: 441 EECRMSGEYTNSVSISVIN 459
>gi|15431316 keratin, hair, basic, 4 [Homo sapiens]
Length = 600
Score = 194 bits (492), Expect = 2e-49
Identities = 121/365 (33%), Positives = 204/365 (55%), Gaps = 14/365 (3%)
Query: 90 IRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRD 149
++ +EKEQ++ LN++FA FI+KV LE QN+ LE + + L+++ S + LF+ + +
Sbjct: 161 VKKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPLFESYITN 220
Query: 150 LRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLA 209
LR QLE S +++ ER+ L + ++ + + EEE R AE A ++DVD A +
Sbjct: 221 LRRQLEVLVSDQARLQAERNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKDVDAAFMN 280
Query: 210 RLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALREIR 269
+ DLE V++L E+ F++ ++ EE+ +LL + + + ++D + +L + E++
Sbjct: 281 KSDLEANVDTLTQEIDFLKTLYMEEI-QLLQSHISETSVIVKMDNS-RDLNLDGIIAEVK 338
Query: 270 AQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGL 329
AQYE +A ++ AE WY++K+ + A + + +R R EI+E R +Q EIE
Sbjct: 339 AQYEEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLKAEIEHA 398
Query: 330 RGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMAL 389
+ LE + E E++ A ++ + + LE L+ K +MAR L EYQ+L+N K+ L
Sbjct: 399 KAQRAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLCEYQELMNAKLGL 458
Query: 390 DIEIAAYRKLLEGEETRF------------STSGLSISGLNPLPNPSYLLPPRILSATTS 437
DIEIA YR+LLEGEE+R S+ G + G PL S L + + +S
Sbjct: 459 DIEIATYRRLLEGEESRLCEGVGPVNISVSSSRGGLVCGPEPLVAGSTLSRGGVTFSGSS 518
Query: 438 KVSST 442
V +T
Sbjct: 519 SVCAT 523
>gi|24430192 keratin 16 [Homo sapiens]
Length = 473
Score = 194 bits (492), Expect = 2e-49
Identities = 131/400 (32%), Positives = 200/400 (50%), Gaps = 16/400 (4%)
Query: 19 FGDGSRLSARLSGAGGAG---GFRSQSLSRSNVASSAACSSASSLGLGLAYRRPPASDGL 75
+G G +S+R S G G G+ S S+ S LG G GL
Sbjct: 46 YGGGLSVSSRFSSGGACGLGGGYGGGFSSSSSFGSGFGGGYGGGLGAGFG-------GGL 98
Query: 76 DLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAE 135
++ +EK +Q LNDR A +++KV LE N LE ++ QR
Sbjct: 99 GAGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQ-R 157
Query: 136 PSRVGEL--FQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAE 193
PS + + + + + DLR ++ A+ +Q +L+ D R + E E R+ E
Sbjct: 158 PSEIKDYSPYFKTIEDLRNKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVE 217
Query: 194 RALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVD 253
+ +R +D TLAR DLE ++E L +ELA++R+ H+EE+ L Q E+D
Sbjct: 218 ADVNGLRRVLDELTLARTDLEMQIEGLKEELAYLRKNHEEEMLALRG--QTGGDVNVEMD 275
Query: 254 VTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIH 313
DL+ L E+R QYE +A KN + AE W+ SK LN++ A ++E +++SR E+
Sbjct: 276 AAPGV-DLSRILNEMRDQYEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVT 334
Query: 314 EYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMA 373
E RR LQ IE++ SLE + E + R+ +++ Q IG +E L + EM
Sbjct: 335 ELRRVLQGLEIELQSQLSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEME 394
Query: 374 RHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLS 413
+ +EYQ LL+VK L+ EIA YR+LLEGE+ S+ S
Sbjct: 395 QQSQEYQILLDVKTRLEQEIATYRRLLEGEDAHLSSQQAS 434
>gi|153791670 keratin 76 [Homo sapiens]
Length = 638
Score = 191 bits (485), Expect = 1e-48
Identities = 129/411 (31%), Positives = 212/411 (51%), Gaps = 30/411 (7%)
Query: 14 SYRKVFGDGSRLSARLSGAGG---AGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPP 70
SY FG G + + GAGG AGGF + + G G P
Sbjct: 101 SYGGGFGGGRGVGSGFGGAGGFGGAGGFGGPGV----FGGPGSFGGPGGFGPG---GFPG 153
Query: 71 ASDGLDLSQAAARTNEYKI------IRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEA 124
+ ++Q+ + +I ++ E+EQ++ LN++FA FI+KV LE QN+ LE
Sbjct: 154 GIQEVIVNQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLET 213
Query: 125 ELAALRQRH--AEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRARC 182
+ L+Q+ + PS + F+ + L QL+ R E + + V+ + +
Sbjct: 214 KWELLQQQTTGSGPSSLEPCFESYISFLCKQLDSLLGERGNLEGELKSMQDLVEDFKKKY 273
Query: 183 EEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLATL 242
E+E R AE ++DVD A + +++L+ KV+SL DE++F+R +++ E++++
Sbjct: 274 EDEINKRTAAENEFVGLKKDVDAAFMNKVELQAKVDSLTDEVSFLRTLYEMELSQM---- 329
Query: 243 QASSQAAAEVDVTVAKP-----DLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQ 297
A++ V ++ DL S + E+RAQYE +A ++ AE Y++K L
Sbjct: 330 ---QSHASDTSVVLSMDNNRCLDLGSIIAEVRAQYEEIAQRSKSEAEALYQTKLGELQTT 386
Query: 298 AARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDS 357
A R + +R ++ EI E R +Q EIE ++ N +L+ I E E+R +
Sbjct: 387 AGRHGDDLRNTKSEIMELNRMIQRLRAEIENVKKQNANLQTAIAEAEQRGEMALKDANAK 446
Query: 358 IGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFS 408
+ L+ L+ K ++AR LR+YQ+L+NVK+ALD+EIA YRKLLEGEE R S
Sbjct: 447 LQDLQTALQKAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMS 497
>gi|131412225 keratin 13 isoform a [Homo sapiens]
Length = 458
Score = 191 bits (484), Expect = 2e-48
Identities = 140/447 (31%), Positives = 218/447 (48%), Gaps = 30/447 (6%)
Query: 11 SSSSYRKVFGDGS----------RLSARLSGAGGAGGFRSQSLSRSNVASSAACSSASSL 60
SS+SY FG GS S R G AGG+ + +
Sbjct: 8 SSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSGFGGGYGG 67
Query: 61 GLGLAYRRPPASDGLDLSQAAARTN----EYKIIRTNEKEQLQGLNDRFAVFIEKVHQLE 116
GLG Y G A + + ++ NEK +Q LNDR A ++EKV LE
Sbjct: 68 GLGGGYGGG-LGGGFGGGFAGGFVDFGACDGGLLTGNEKITMQNLNDRLASYLEKVRALE 126
Query: 117 TQNRALEAELAA--LRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEE 174
N LE ++ L+Q A P R + + + +LR ++ A+ ++ +LE D
Sbjct: 127 EANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEIDNARLA 186
Query: 175 VQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEE 234
R + E E R+ E + +R +D TL++ DLE ++ESL +ELA++++ H+EE
Sbjct: 187 ADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEE 246
Query: 235 VAELLATLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANL 294
+ E + Q Q E+D T DLT L E+R QYE++A +N + AEEW+ +K A L
Sbjct: 247 MKEF--SNQVVGQVNVEMDATPGI-DLTRVLAEMREQYEAMAERNRRDAEEWFHAKSAEL 303
Query: 295 NEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGY 354
N++ + +T I+ S+ EI E RR LQ IE++ LE + E E R++ ++
Sbjct: 304 NKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENTVAETECRYALQLQQI 363
Query: 355 QDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSI 414
Q I +E L +SEM +EY+ LL++K L+ EIA YR LLEG++ +
Sbjct: 364 QGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAK-------- 415
Query: 415 SGLNPLPNPSYLLPPRILSATTSKVSS 441
+ P+ + + PR S TT+ +S
Sbjct: 416 --MIGFPSSAGSVSPRSTSVTTTSSAS 440
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.124 0.320
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,662,861
Number of Sequences: 37866
Number of extensions: 663325
Number of successful extensions: 8070
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 288
Number of HSP's successfully gapped in prelim test: 640
Number of HSP's that attempted gapping in prelim test: 4670
Number of HSP's gapped (non-prelim): 2434
length of query: 499
length of database: 18,247,518
effective HSP length: 106
effective length of query: 393
effective length of database: 14,233,722
effective search space: 5593852746
effective search space used: 5593852746
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.