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Search of human proteins with 14165402
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14165402 protocadherin alpha 1 isoform 3 precursor [Homo
sapiens]
(686 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14165402 protocadherin alpha 1 isoform 3 precursor [Homo sapi... 1363 0.0
gi|14165394 protocadherin alpha 6 isoform 3 precursor [Homo sapi... 1094 0.0
gi|14165383 protocadherin alpha 10 isoform 3 precursor [Homo sap... 1089 0.0
gi|14165400 protocadherin alpha 1 isoform 2 precursor [Homo sapi... 1048 0.0
gi|9256582 protocadherin alpha 1 isoform 1 precursor [Homo sapiens] 1048 0.0
gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo sapi... 817 0.0
gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens] 817 0.0
gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens] 815 0.0
gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo sapi... 815 0.0
gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo sapi... 796 0.0
gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens] 796 0.0
gi|9256586 protocadherin alpha 3 isoform 1 precursor [Homo sapiens] 795 0.0
gi|14165410 protocadherin alpha 3 isoform 2 precursor [Homo sapi... 795 0.0
gi|14165413 protocadherin alpha 4 isoform 2 precursor [Homo sapi... 793 0.0
gi|9256588 protocadherin alpha 4 isoform 1 precursor [Homo sapiens] 793 0.0
gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo sap... 792 0.0
gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo sapi... 792 0.0
gi|7662068 protocadherin alpha 9 isoform 2 precursor [Homo sapiens] 791 0.0
gi|14165425 protocadherin alpha 9 isoform 1 precursor [Homo sapi... 791 0.0
gi|14165387 protocadherin alpha 11 isoform 2 precursor [Homo sap... 788 0.0
gi|9256576 protocadherin alpha 11 isoform 1 precursor [Homo sapi... 788 0.0
gi|14165419 protocadherin alpha 7 isoform 2 precursor [Homo sapi... 786 0.0
gi|9256594 protocadherin alpha 7 isoform 1 precursor [Homo sapiens] 786 0.0
gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo sapi... 780 0.0
gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens] 780 0.0
gi|14165381 protocadherin alpha 10 isoform 2 precursor [Homo sap... 775 0.0
gi|9256574 protocadherin alpha 10 isoform 1 precursor [Homo sapi... 775 0.0
gi|14165392 protocadherin alpha 12 isoform 2 precursor [Homo sap... 758 0.0
gi|9256578 protocadherin alpha 12 isoform 1 precursor [Homo sapi... 758 0.0
gi|14277677 protocadherin gamma subfamily C, 3 isoform 2 precurs... 468 e-131
>gi|14165402 protocadherin alpha 1 isoform 3 precursor [Homo
sapiens]
Length = 686
Score = 1363 bits (3527), Expect = 0.0
Identities = 686/686 (100%), Positives = 686/686 (100%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV
Sbjct: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE
Sbjct: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL
Sbjct: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP
Sbjct: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG
Sbjct: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR
Sbjct: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV
Sbjct: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQPRQPNP 540
DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQPRQPNP
Sbjct: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQPRQPNP 540
Query: 541 DWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNS 600
DWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNS
Sbjct: 541 DWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNS 600
Query: 601 NSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKK 660
NSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKK
Sbjct: 601 NSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKK 660
Query: 661 KKKKKKGNKTQEKKEKGNSTTDNSDQ 686
KKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 661 KKKKKKGNKTQEKKEKGNSTTDNSDQ 686
>gi|14165394 protocadherin alpha 6 isoform 3 precursor [Homo
sapiens]
Length = 686
Score = 1094 bits (2830), Expect = 0.0
Identities = 544/686 (79%), Positives = 604/686 (88%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
MVF+ LG + LLL LLLLAAW+VGSGQLHYS+PEEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFR+ASK DLLEVNLQNGILFVNSRIDREELC SAECSIHLE+I DRPLQVFHV+
Sbjct: 61 PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+V+DINDNPP+F EQ + I ESRL +S FP+EGA+DAD+G+N++LTY LS S+YF L
Sbjct: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DV+ + + +K + L L+K LDREE P +L LTATDGGKPEL GTV+LL+TVLDVNDNAP
Sbjct: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
F+Q+ Y V + E NGT V LNASD DEG NG + +SF+S ++ + + F +D ++G
Sbjct: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EI + LD+E+ Y+I + A DKG PPM+ HC VLV++LD NDN PE+A+TSL LP+R
Sbjct: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDA TVIALI+V+D DSGANGQV CSL PHVPFKLVSTFKNYYSLVLDSALDRES+S
Sbjct: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATA +SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQPRQPNP 540
DADAQENALVSYSLVERRVGERALS+Y+SVHAESGKVYALQPLDHEELELLQFQPRQPNP
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQPRQPNP 540
Query: 541 DWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNS 600
DWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNS
Sbjct: 541 DWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNS 600
Query: 601 NSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKK 660
NSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKK
Sbjct: 601 NSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKK 660
Query: 661 KKKKKKGNKTQEKKEKGNSTTDNSDQ 686
KKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 661 KKKKKKGNKTQEKKEKGNSTTDNSDQ 686
>gi|14165383 protocadherin alpha 10 isoform 3 precursor [Homo
sapiens]
Length = 685
Score = 1089 bits (2817), Expect = 0.0
Identities = 547/683 (80%), Positives = 599/683 (87%)
Query: 4 SRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRL 63
SR LG + LLL LLLLAAWEVGSGQLHYS+ EEA+HGTFVGR+AQDLGLELAELV RL
Sbjct: 3 SRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRL 62
Query: 64 FRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKV 123
FRVASK H DLLEVNLQNGILFVNSRIDREELC S ECSIHLE+I DRPLQVFHV+V+V
Sbjct: 63 FRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEV 122
Query: 124 KDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVE 183
KDINDNPP F EQ + IPESRLL+SRFP+EGA+DAD+G NALLTY LSP++YF LD+
Sbjct: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDII 182
Query: 184 ASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFD 243
+ K L LRK LDREE P+L LLLTATDGGKPE G+V LLI VLD NDNAP+FD
Sbjct: 183 NKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFD 242
Query: 244 QAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIR 303
+ VY V + E N TLV LNASD+DEG+N E+++SF S + I+ KF ++ +GEI+
Sbjct: 243 RPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIK 302
Query: 304 LIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDA 363
+ D +D+E++ +YEI V DKG+PPM HC VLV++LD NDN+PE+ VTSL LP++EDA
Sbjct: 303 VNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDA 362
Query: 364 PLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYEL 423
+ TVIALI+VSD DSGANGQVTCSL PHVPFKLVST+KNYYSLVLDSALDRE +S YEL
Sbjct: 363 QVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYEL 422
Query: 424 VVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDAD 483
VVTARDGGSP LWATA VSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DAD
Sbjct: 423 VVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDAD 482
Query: 484 AQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQPRQPNPDWR 543
AQENALVSYSLVERR+GER+LS+YVSVHAESGKVYALQPLDHEELELLQFQPRQPNPDWR
Sbjct: 483 AQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQPRQPNPDWR 542
Query: 544 YSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSW 603
YSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSW
Sbjct: 543 YSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSW 602
Query: 604 TFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKK 663
TFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKK
Sbjct: 603 TFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKK 662
Query: 664 KKKGNKTQEKKEKGNSTTDNSDQ 686
KKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 663 KKKGNKTQEKKEKGNSTTDNSDQ 685
>gi|14165400 protocadherin alpha 1 isoform 2 precursor [Homo
sapiens]
Length = 807
Score = 1048 bits (2711), Expect = 0.0
Identities = 534/534 (100%), Positives = 534/534 (100%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV
Sbjct: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE
Sbjct: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL
Sbjct: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP
Sbjct: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG
Sbjct: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR
Sbjct: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV
Sbjct: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 151 bits (382), Expect = 2e-36
Identities = 128/423 (30%), Positives = 189/423 (44%), Gaps = 25/423 (5%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
+ V D+NDN P+F + + E+ + A+DAD G N + ++ S
Sbjct: 230 ITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSG--ISR 287
Query: 181 DVEASDEL-SKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNA 239
D++ ++ S S + L LD EET + + A D G P + ++L+ VLDVNDNA
Sbjct: 288 DIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNA 347
Query: 240 PLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSS 299
P + + E T++ + SD D G NG+V S + + FK S
Sbjct: 348 PELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYS- 406
Query: 300 GEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPI 359
+ L LD E YE+ V A D GSP + +V V+V DVNDNAP A + +
Sbjct: 407 --LVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFV 464
Query: 360 REDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSA------- 412
+E+ P I ++ D D+ N V+ SL+ + NY S+ +S
Sbjct: 465 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGE--RALSNYVSVHAESGKVYALQP 522
Query: 413 LDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEY--TVFVKENNPP 470
LD E L + + V+ARD G P L + + V V D NDNAPA P T+ P
Sbjct: 523 LDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVP 582
Query: 471 -----GCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDH 525
G + V A DAD+ NA +SY L G R V +G++ + LD
Sbjct: 583 RLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARI---PFRVGLYTGEISTTRVLDE 639
Query: 526 EEL 528
+L
Sbjct: 640 ADL 642
Score = 150 bits (380), Expect = 3e-36
Identities = 118/346 (34%), Positives = 163/346 (47%), Gaps = 27/346 (7%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
V VKV D+NDN P + I E L++ + +D D GAN +T +L P F
Sbjct: 336 VLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPF 395
Query: 179 SLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDN 238
L + S L L LDRE L++TA DGG P L T + + V DVNDN
Sbjct: 396 KLVSTFKNYYS----LVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDN 451
Query: 239 APLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK-----F 293
AP F Q Y V + E G + T++A DAD N V +S + R + E+
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL---VERRVGERALSNYV 508
Query: 294 KVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL--- 350
V + SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L
Sbjct: 509 SVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAP 568
Query: 351 AVTSLYLPIREDAP----LSTVIALITVSDRDSGANGQVTCSLMP-----HVPFKLVSTF 401
V + E P V+A + D DSG N ++ L P +PF+ V +
Sbjct: 569 RVGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFR-VGLY 627
Query: 402 KNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVAD 447
S LD LS Y L+V +D G P+L ATA V V + +
Sbjct: 628 TGEISTT--RVLDEADLSRYRLLVLVKDHGEPALTATATVLVSLVE 671
>gi|9256582 protocadherin alpha 1 isoform 1 precursor [Homo sapiens]
Length = 950
Score = 1048 bits (2711), Expect = 0.0
Identities = 534/534 (100%), Positives = 534/534 (100%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV
Sbjct: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE
Sbjct: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL
Sbjct: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP
Sbjct: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG
Sbjct: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR
Sbjct: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV
Sbjct: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 423 bits (1087), Expect = e-118
Identities = 284/625 (45%), Positives = 350/625 (56%), Gaps = 67/625 (10%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
V VKV D+NDN P + I E L++ + +D D GAN +T +L P F
Sbjct: 336 VLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPF 395
Query: 179 SLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDN 238
L + S L L LDRE L++TA DGG P L T + + V DVNDN
Sbjct: 396 KLVSTFKNYYS----LVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDN 451
Query: 239 APLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK-----F 293
AP F Q Y V + E G + T++A DAD N V +S + R + E+
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL---VERRVGERALSNYV 508
Query: 294 KVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVT 353
V + SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L
Sbjct: 509 SVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAP 568
Query: 354 SLYLPIREDAPL-------STVIALITVSDRDSGANGQVTCSLMP-----HVPFKL---- 397
+ I + L V+A + D DSG N ++ L P +PF++
Sbjct: 569 RVGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFRVGLYT 628
Query: 398 --VSTFK--------NYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVA- 446
+ST + Y LVL +L+ V+ + + A++R SV VA
Sbjct: 629 GEISTTRVLDEADLSRYRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVGVAG 688
Query: 447 ------DVN----------DNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALV 490
DVN + YT ++ + PP + V + +AL
Sbjct: 689 PEAALVDVNVYLIIAICAVSSLLVLTLLLYTA-LRCSVPPTEGAY-VPGKPTLVCSSALG 746
Query: 491 SYSLVERRVGERALSNYVSVHAE--------SGKVYALQPLDHEELEL-LQFQPRQPNPD 541
S+S ++R +R S+ + S + + + E L L PRQPNPD
Sbjct: 747 SWSNSQQR-RQRVCSSEGPPKTDLMAFSPGLSPSLNTSERNEQPEANLDLSGNPRQPNPD 805
Query: 542 WRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSN 601
WRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSN
Sbjct: 806 WRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSN 865
Query: 602 SWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKK 661
SWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKK
Sbjct: 866 SWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKK 925
Query: 662 KKKKKGNKTQEKKEKGNSTTDNSDQ 686
KKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 926 KKKKKGNKTQEKKEKGNSTTDNSDQ 950
Score = 151 bits (382), Expect = 2e-36
Identities = 128/423 (30%), Positives = 189/423 (44%), Gaps = 25/423 (5%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
+ V D+NDN P+F + + E+ + A+DAD G N + ++ S
Sbjct: 230 ITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSG--ISR 287
Query: 181 DVEASDEL-SKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNA 239
D++ ++ S S + L LD EET + + A D G P + ++L+ VLDVNDNA
Sbjct: 288 DIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNA 347
Query: 240 PLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSS 299
P + + E T++ + SD D G NG+V S + + FK S
Sbjct: 348 PELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYS- 406
Query: 300 GEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPI 359
+ L LD E YE+ V A D GSP + +V V+V DVNDNAP A + +
Sbjct: 407 --LVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFV 464
Query: 360 REDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSA------- 412
+E+ P I ++ D D+ N V+ SL+ + NY S+ +S
Sbjct: 465 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGE--RALSNYVSVHAESGKVYALQP 522
Query: 413 LDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEY--TVFVKENNPP 470
LD E L + + V+ARD G P L + + V V D NDNAPA P T+ P
Sbjct: 523 LDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVP 582
Query: 471 -----GCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDH 525
G + V A DAD+ NA +SY L G R V +G++ + LD
Sbjct: 583 RLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARI---PFRVGLYTGEISTTRVLDE 639
Query: 526 EEL 528
+L
Sbjct: 640 ADL 642
>gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo
sapiens]
Length = 824
Score = 817 bits (2110), Expect = 0.0
Identities = 419/534 (78%), Positives = 460/534 (86%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
M S R G GA LL LLLLAAWEVGSGQL YS+PEEAKHGTFVGR+AQDLGLEL ELV
Sbjct: 1 MASSIRRGRGAWTRLLSLLLLAAWEVGSGQLRYSVPEEAKHGTFVGRIAQDLGLELEELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK H DLLEVNLQNGILFVNSRIDREELC SAECSIH+E+I DRPLQVFHVE
Sbjct: 61 PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHVEVIVDRPLQVFHVE 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+VKDINDNPP+F + I PESRLL+SRFP+EGA+DADIG NALL+Y LS S++F L
Sbjct: 121 VEVKDINDNPPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFFFL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
D++A+DELS+SL L L K LDREET E++LLL ATDGGKPEL GTV++LI VLDVNDN P
Sbjct: 181 DIQANDELSESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
F Q+VY+V LLE TANGTLV LNASDADEG N E+V+S S +S IQ KF +D SG
Sbjct: 241 TFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EIR KLDYEE KSYEIQV A DKG+P MS HCK+ +K++D+NDN PE+++TSL LPI
Sbjct: 301 EIRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPIS 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
E+A L TVIALITVSDRDSG NG VTCSL PHVPFKLVSTFKNYYSLVLDSALDRES+S
Sbjct: 361 ENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWAT VS+EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA
Sbjct: 421 YELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGERALS+YVSVHAESGKVYALQPLDHEE+ELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQ 534
Score = 151 bits (381), Expect = 2e-36
Identities = 124/429 (28%), Positives = 200/429 (46%), Gaps = 29/429 (6%)
Query: 84 LFVNSRIDREELCQWSAECSIHLELIAD---RPLQVFHVEV--KVKDINDNPPVFRGREQ 138
L + +DREE + ++L L+A +P V++ KV D+NDN P F
Sbjct: 194 LVLGKSLDREETAE------VNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVY 247
Query: 139 IIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEAS-DELSKSLWLELR 197
+ + E+ + A+DAD G N+ + Y+L ++ + + D +S + +
Sbjct: 248 KVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEI--RTK 305
Query: 198 KYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTAN 257
LD EE + +TATD G P + G ++ + ++D+NDN P + + E +
Sbjct: 306 GKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASL 365
Query: 258 GTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKSYE 317
GT++ + SD D G NG V S + + FK S + L LD E +YE
Sbjct: 366 GTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYS---LVLDSALDRESVSAYE 422
Query: 318 IQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVSDR 377
+ V A D GSP + V ++V DVNDNAP A + ++E+ P I ++ D
Sbjct: 423 LVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDA 482
Query: 378 DSGANGQVTCSLMPH-VPFKLVSTFKNYYS----LVLDSALDRESLSVYELVVTARDGGS 432
D+ N V+ SL+ V + +S++ + ++ + LD E + + + V+ARD G
Sbjct: 483 DAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGV 542
Query: 433 PSLWATARVSVEVADVNDNAPAFAQPE-------YTVFVKENNPPGCHIFTVSARDADAQ 485
P L + + V V D NDNAPA P + V + G + V A DAD+
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDADSG 602
Query: 486 ENALVSYSL 494
NA +SY L
Sbjct: 603 YNAWLSYEL 611
Score = 142 bits (357), Expect = 1e-33
Identities = 113/346 (32%), Positives = 162/346 (46%), Gaps = 27/346 (7%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
+ +K+ DINDN P + I E+ L + + +D D G N +T +L+P F
Sbjct: 336 ISLKLVDINDNTPEVSITSLSLPISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPF 395
Query: 179 SLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDN 238
L + S L L LDRE L++TA DGG P L T + I V DVNDN
Sbjct: 396 KLVSTFKNYYS----LVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDN 451
Query: 239 APLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK-----F 293
AP F Q Y V + E G + T++A DAD N V +S + R + E+
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL---VERRVGERALSSYV 508
Query: 294 KVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVT 353
V + SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L
Sbjct: 509 SVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAP 568
Query: 354 ---SLYLPIREDAPLST----VIALITVSDRDSGANGQVTCSLM-----PHVPFKLVSTF 401
+ + E P S V+A + D DSG N ++ L +PF+ V +
Sbjct: 569 RAGTAAGAVSELVPWSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFR-VGLY 627
Query: 402 KNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVAD 447
S ALD + L+V +D G P+L ATA V V + +
Sbjct: 628 TGEISTT--RALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVE 671
>gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens]
Length = 948
Score = 817 bits (2110), Expect = 0.0
Identities = 419/534 (78%), Positives = 460/534 (86%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
M S R G GA LL LLLLAAWEVGSGQL YS+PEEAKHGTFVGR+AQDLGLEL ELV
Sbjct: 1 MASSIRRGRGAWTRLLSLLLLAAWEVGSGQLRYSVPEEAKHGTFVGRIAQDLGLELEELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK H DLLEVNLQNGILFVNSRIDREELC SAECSIH+E+I DRPLQVFHVE
Sbjct: 61 PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHVEVIVDRPLQVFHVE 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+VKDINDNPP+F + I PESRLL+SRFP+EGA+DADIG NALL+Y LS S++F L
Sbjct: 121 VEVKDINDNPPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFFFL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
D++A+DELS+SL L L K LDREET E++LLL ATDGGKPEL GTV++LI VLDVNDN P
Sbjct: 181 DIQANDELSESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
F Q+VY+V LLE TANGTLV LNASDADEG N E+V+S S +S IQ KF +D SG
Sbjct: 241 TFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EIR KLDYEE KSYEIQV A DKG+P MS HCK+ +K++D+NDN PE+++TSL LPI
Sbjct: 301 EIRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPIS 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
E+A L TVIALITVSDRDSG NG VTCSL PHVPFKLVSTFKNYYSLVLDSALDRES+S
Sbjct: 361 ENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWAT VS+EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA
Sbjct: 421 YELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGERALS+YVSVHAESGKVYALQPLDHEE+ELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQ 534
Score = 430 bits (1106), Expect = e-120
Identities = 279/623 (44%), Positives = 345/623 (55%), Gaps = 65/623 (10%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
+ +K+ DINDN P + I E+ L + + +D D G N +T +L+P F
Sbjct: 336 ISLKLVDINDNTPEVSITSLSLPISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPF 395
Query: 179 SLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDN 238
L + S L L LDRE L++TA DGG P L T + I V DVNDN
Sbjct: 396 KLVSTFKNYYS----LVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDN 451
Query: 239 APLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK-----F 293
AP F Q Y V + E G + T++A DAD N V +S + R + E+
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL---VERRVGERALSSYV 508
Query: 294 KVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVT 353
V + SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L
Sbjct: 509 SVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAP 568
Query: 354 ---SLYLPIREDAPLST----VIALITVSDRDSGANGQVTCSLM-----PHVPFKLVSTF 401
+ + E P S V+A + D DSG N ++ L +PF+ V +
Sbjct: 569 RAGTAAGAVSELVPWSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFR-VGLY 627
Query: 402 KNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYT 461
S ALD + L+V +D G P+L ATA V V + + A ++
Sbjct: 628 TGEISTT--RALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRAWVG 685
Query: 462 VFVKENNPPGCHIFTVSARDADAQENAL--VSYSLVERRV----GERALSNYVSV----- 510
E +++ + A A + L + Y+ + V G RA V
Sbjct: 686 AAGSEATLVDVNVYLIIAICAVSSLLVLTVLLYTALRCSVPPTEGARAPGKPTLVCSSAV 745
Query: 511 ----HAESGKVYALQPLDHEELELLQFQP-----------------------RQPNPDWR 543
+++ + D + +L+ F P RQPNPDWR
Sbjct: 746 GSWSYSQQRRQRVCSGEDPPKTDLMAFSPSLSQGPDSAEEKQLSESEYVGKPRQPNPDWR 805
Query: 544 YSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSW 603
YSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSW
Sbjct: 806 YSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSW 865
Query: 604 TFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKK 663
TFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKK
Sbjct: 866 TFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKK 925
Query: 664 KKKGNKTQEKKEKGNSTTDNSDQ 686
KKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 926 KKKGNKTQEKKEKGNSTTDNSDQ 948
Score = 151 bits (381), Expect = 2e-36
Identities = 124/429 (28%), Positives = 200/429 (46%), Gaps = 29/429 (6%)
Query: 84 LFVNSRIDREELCQWSAECSIHLELIAD---RPLQVFHVEV--KVKDINDNPPVFRGREQ 138
L + +DREE + ++L L+A +P V++ KV D+NDN P F
Sbjct: 194 LVLGKSLDREETAE------VNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVY 247
Query: 139 IIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEAS-DELSKSLWLELR 197
+ + E+ + A+DAD G N+ + Y+L ++ + + D +S + +
Sbjct: 248 KVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEI--RTK 305
Query: 198 KYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTAN 257
LD EE + +TATD G P + G ++ + ++D+NDN P + + E +
Sbjct: 306 GKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASL 365
Query: 258 GTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKSYE 317
GT++ + SD D G NG V S + + FK S + L LD E +YE
Sbjct: 366 GTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYS---LVLDSALDRESVSAYE 422
Query: 318 IQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVSDR 377
+ V A D GSP + V ++V DVNDNAP A + ++E+ P I ++ D
Sbjct: 423 LVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDA 482
Query: 378 DSGANGQVTCSLMPH-VPFKLVSTFKNYYS----LVLDSALDRESLSVYELVVTARDGGS 432
D+ N V+ SL+ V + +S++ + ++ + LD E + + + V+ARD G
Sbjct: 483 DAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGV 542
Query: 433 PSLWATARVSVEVADVNDNAPAFAQPE-------YTVFVKENNPPGCHIFTVSARDADAQ 485
P L + + V V D NDNAPA P + V + G + V A DAD+
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDADSG 602
Query: 486 ENALVSYSL 494
NA +SY L
Sbjct: 603 YNAWLSYEL 611
>gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens]
Length = 936
Score = 815 bits (2106), Expect = 0.0
Identities = 412/534 (77%), Positives = 469/534 (87%), Gaps = 1/534 (0%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
MV+SRRG LG+R LLLWLLL A W+ GSGQLHYSIPEEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MVYSRRGSLGSRLLLLWLLL-AYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELV 59
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK DLLEVNLQNGILFVNSRIDREELC+ AECSIHLE+I DRPLQVFHVE
Sbjct: 60 PRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVE 119
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V VKDINDNPP F +EQ +FI ESR+ +SRFP+EGA+D DIGANA L Y L+P++YF L
Sbjct: 120 VAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDL 179
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DV+ ++E + L L LRK LDREET E LL+ ATDGGKPEL GTV+LLI VLD NDNAP
Sbjct: 180 DVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAP 239
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
FD+++Y V LLE +GTLV LNASDADEG+N E+V+ F + + D++ KF ++S++G
Sbjct: 240 EFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTG 299
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EI++ +LDYE+ SYEI + A+DK + P+S HCKV+VK+LDVNDN PE+A+T+L+LP++
Sbjct: 300 EIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVK 359
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDAPLSTVIALI+VSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRES+SV
Sbjct: 360 EDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSV 419
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATA VSVEVADVNDNAPAFAQP+YTVFVKENNPPGCHIFTVSAR
Sbjct: 420 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSAR 479
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGER LS+YVSVHAESGKVYALQPLDHEE+ELLQFQ
Sbjct: 480 DADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQ 533
Score = 439 bits (1129), Expect = e-123
Identities = 289/655 (44%), Positives = 358/655 (54%), Gaps = 57/655 (8%)
Query: 77 VNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVF-HVEVKVKDINDNPPVFRG 135
+N G + VN +D E+ + E +I + PL V VK+ D+NDN P
Sbjct: 294 INSNTGEIKVNGELDYEDYNSY--EINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAI 351
Query: 136 REQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLWLE 195
+ + E L++ + +D D GAN +T +L P F L + S L
Sbjct: 352 TTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYS----LV 407
Query: 196 LRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETT 255
L LDRE L++TA DGG P L T + + V DVNDNAP F Q Y V + E
Sbjct: 408 LDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENN 467
Query: 256 ANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK-----FKVDSSSGEIRLIDKLDY 310
G + T++A DAD N V +S + R + E+ V + SG++ + LD+
Sbjct: 468 PPGCHIFTVSARDADAQENALVSYSL---VERRVGERPLSSYVSVHAESGKVYALQPLDH 524
Query: 311 EETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLP---IREDAPLST 367
EE + + QV A D G PP+ ++ + V VLD NDNAP L V + + E P S
Sbjct: 525 EEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSV 584
Query: 368 ----VIALITVSDRDSGANGQVTCSLMP-----HVPFKLVSTFKNYYSLVLDSALDRESL 418
V+A + D DSG N ++ L P +PF+ V + S +LD
Sbjct: 585 GAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFR-VGLYTGEISTT--RSLDETEA 641
Query: 419 SVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVS 478
+ L+V +D G P L ATA V V + + A ++ E +++ +
Sbjct: 642 PRHRLLVLVKDHGEPPLTATATVLVSLVESGQAPKASSRASAGAVGPEAALVDVNVYLII 701
Query: 479 ARDADAQ--------ENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDH----- 525
A A + AL + V R + A Y+ Q
Sbjct: 702 AICAVSSLLVLTLLLYTALRCSAQPTEAVCTRGKPTLLCSSAVGSWSYSQQRRQRVCSGE 761
Query: 526 --EELELLQFQP------------RQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGP 571
+ +L+ F P RQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGP
Sbjct: 762 APPKTDLMAFSPSLPQGPTSTDNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGP 821
Query: 572 DQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPA 631
DQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPA
Sbjct: 822 DQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPA 881
Query: 632 IISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
IISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 882 IISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 936
Score = 125 bits (315), Expect = 1e-28
Identities = 116/420 (27%), Positives = 189/420 (45%), Gaps = 21/420 (5%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
+ V D NDN P F + + E+ + A+DAD G N + Y S +
Sbjct: 229 INVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFS--NLVLD 286
Query: 181 DVEASDELSKSLW-LELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNA 239
DV++ ++ + +++ LD E+ + + A D L G ++++ +LDVNDN
Sbjct: 287 DVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNT 346
Query: 240 PLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSS 299
P + + E T++ ++ SD D G NG+V S + + FK S
Sbjct: 347 PEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYS- 405
Query: 300 GEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPI 359
+ L LD E YE+ V A D GSP + V V+V DVNDNAP A + +
Sbjct: 406 --LVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFV 463
Query: 360 REDAPLSTVIALITVSDRDSGANGQVTCSLMPH-VPFKLVSTFKNYYS----LVLDSALD 414
+E+ P I ++ D D+ N V+ SL+ V + +S++ + ++ + LD
Sbjct: 464 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLD 523
Query: 415 RESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPE-------YTVFVKEN 467
E + + + V+ARD G P L + + V V D NDNAPA P + V +
Sbjct: 524 HEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRS 583
Query: 468 NPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEE 527
G + V A D D+ NA +SY L + G + V ++ +G++ + LD E
Sbjct: 584 VGAGHVVAKVRAVDPDSGYNAWLSYEL-QPAPGSARIPFRVGLY--TGEISTTRSLDETE 640
>gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo
sapiens]
Length = 816
Score = 815 bits (2106), Expect = 0.0
Identities = 412/534 (77%), Positives = 469/534 (87%), Gaps = 1/534 (0%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
MV+SRRG LG+R LLLWLLL A W+ GSGQLHYSIPEEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MVYSRRGSLGSRLLLLWLLL-AYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELV 59
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK DLLEVNLQNGILFVNSRIDREELC+ AECSIHLE+I DRPLQVFHVE
Sbjct: 60 PRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVE 119
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V VKDINDNPP F +EQ +FI ESR+ +SRFP+EGA+D DIGANA L Y L+P++YF L
Sbjct: 120 VAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDL 179
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DV+ ++E + L L LRK LDREET E LL+ ATDGGKPEL GTV+LLI VLD NDNAP
Sbjct: 180 DVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAP 239
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
FD+++Y V LLE +GTLV LNASDADEG+N E+V+ F + + D++ KF ++S++G
Sbjct: 240 EFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTG 299
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EI++ +LDYE+ SYEI + A+DK + P+S HCKV+VK+LDVNDN PE+A+T+L+LP++
Sbjct: 300 EIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVK 359
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDAPLSTVIALI+VSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRES+SV
Sbjct: 360 EDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSV 419
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATA VSVEVADVNDNAPAFAQP+YTVFVKENNPPGCHIFTVSAR
Sbjct: 420 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSAR 479
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGER LS+YVSVHAESGKVYALQPLDHEE+ELLQFQ
Sbjct: 480 DADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQ 533
Score = 149 bits (375), Expect = 1e-35
Identities = 124/389 (31%), Positives = 180/389 (46%), Gaps = 30/389 (7%)
Query: 77 VNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVF-HVEVKVKDINDNPPVFRG 135
+N G + VN +D E+ + E +I + PL V VK+ D+NDN P
Sbjct: 294 INSNTGEIKVNGELDYEDYNSY--EINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAI 351
Query: 136 REQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLWLE 195
+ + E L++ + +D D GAN +T +L P F L + S L
Sbjct: 352 TTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYS----LV 407
Query: 196 LRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETT 255
L LDRE L++TA DGG P L T + + V DVNDNAP F Q Y V + E
Sbjct: 408 LDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENN 467
Query: 256 ANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK-----FKVDSSSGEIRLIDKLDY 310
G + T++A DAD N V +S + R + E+ V + SG++ + LD+
Sbjct: 468 PPGCHIFTVSARDADAQENALVSYSL---VERRVGERPLSSYVSVHAESGKVYALQPLDH 524
Query: 311 EETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSL---YLPIREDAPLST 367
EE + + QV A D G PP+ ++ + V VLD NDNAP L V + + E P S
Sbjct: 525 EEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSV 584
Query: 368 ----VIALITVSDRDSGANGQVTCSLMP-----HVPFKLVSTFKNYYSLVLDSALDRESL 418
V+A + D DSG N ++ L P +PF+ V + S +LD
Sbjct: 585 GAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFR-VGLYTGEISTT--RSLDETEA 641
Query: 419 SVYELVVTARDGGSPSLWATARVSVEVAD 447
+ L+V +D G P L ATA V V + +
Sbjct: 642 PRHRLLVLVKDHGEPPLTATATVLVSLVE 670
Score = 125 bits (315), Expect = 1e-28
Identities = 116/420 (27%), Positives = 189/420 (45%), Gaps = 21/420 (5%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
+ V D NDN P F + + E+ + A+DAD G N + Y S +
Sbjct: 229 INVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFS--NLVLD 286
Query: 181 DVEASDELSKSLW-LELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNA 239
DV++ ++ + +++ LD E+ + + A D L G ++++ +LDVNDN
Sbjct: 287 DVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNT 346
Query: 240 PLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSS 299
P + + E T++ ++ SD D G NG+V S + + FK S
Sbjct: 347 PEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYS- 405
Query: 300 GEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPI 359
+ L LD E YE+ V A D GSP + V V+V DVNDNAP A + +
Sbjct: 406 --LVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFV 463
Query: 360 REDAPLSTVIALITVSDRDSGANGQVTCSLMPH-VPFKLVSTFKNYYS----LVLDSALD 414
+E+ P I ++ D D+ N V+ SL+ V + +S++ + ++ + LD
Sbjct: 464 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLD 523
Query: 415 RESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPE-------YTVFVKEN 467
E + + + V+ARD G P L + + V V D NDNAPA P + V +
Sbjct: 524 HEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRS 583
Query: 468 NPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEE 527
G + V A D D+ NA +SY L + G + V ++ +G++ + LD E
Sbjct: 584 VGAGHVVAKVRAVDPDSGYNAWLSYEL-QPAPGSARIPFRVGLY--TGEISTTRSLDETE 640
>gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo
sapiens]
Length = 814
Score = 796 bits (2055), Expect = 0.0
Identities = 397/534 (74%), Positives = 456/534 (85%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
M + RG LG+ LLL LLLLAAW+VGSGQLHYS+PEEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MDYHWRGELGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK HRDLLEV+LQNGILFVNSRIDREELC SAECSIHLE+I DRPLQVFHV+
Sbjct: 61 PRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+VKD+NDNPPVFR ++Q +F+ ESR+ +SRFP+EGA+DAD+GAN++LTY LS DYF L
Sbjct: 121 VEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFML 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DV + ++ +K + L LRK LDRE+ P HL LTATDGGKPEL GTV+LL+TVLDVNDNAP
Sbjct: 181 DVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
F+Q+ Y V + E NGT V LNASD DEG NG + +SF+S + + + F +D ++G
Sbjct: 241 TFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EI + LD+E+ Y+I + A DKG PPM+ HC VLV++LD NDN PE+A+TSL LP+R
Sbjct: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDA TVIALI+V+D DSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRE +S
Sbjct: 361 EDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATA +SVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGER+LS+Y+SVH ESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQ 534
Score = 153 bits (386), Expect = 6e-37
Identities = 120/394 (30%), Positives = 182/394 (46%), Gaps = 32/394 (8%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPS----- 175
V V D+NDN P F E + I E+ + A+D D GAN ++Y+ +
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMV 289
Query: 176 -DYFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLD 234
D+FS+D + + +R LD E+ +L+ ATD G P + G +L+ +LD
Sbjct: 290 IDHFSIDRNTGE-------IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILD 342
Query: 235 VNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFK 294
NDN P + + E GT++ ++ +D D G NG+V S + + FK
Sbjct: 343 KNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFK 402
Query: 295 VDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTS 354
S + L LD E +YE+ V A D GSP + + V+V DVNDNAP A
Sbjct: 403 NYYS---LVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPE 459
Query: 355 LYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSA-- 412
+ ++E+ P I ++ D D+ N V+ SL+ + + +Y S+ +S
Sbjct: 460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGE--RSLSSYISVHTESGKV 517
Query: 413 -----LDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEY------- 460
LD E L + + V+ARD G P L + + V V D NDNAPA +P
Sbjct: 518 YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAA 577
Query: 461 TVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
+ V + G + V A DAD+ NA +SY L
Sbjct: 578 SKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYEL 611
Score = 139 bits (350), Expect = 9e-33
Identities = 110/345 (31%), Positives = 153/345 (44%), Gaps = 25/345 (7%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
V V++ D NDN P + + E + + D D GAN +T +L P F
Sbjct: 336 VLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPF 395
Query: 179 SLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDN 238
L + S L L LDRE L++TA DGG P L T L + V DVNDN
Sbjct: 396 KLVSTFKNYYS----LVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDN 451
Query: 239 APLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGI--SRDIQEKFKVD 296
AP F Q Y V + E G + T++A DAD N V +S R + V
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVH 511
Query: 297 SSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL------ 350
+ SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L
Sbjct: 512 TESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVG 571
Query: 351 ---AVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLM-----PHVPFKLVSTFK 402
S +P V+A + D DSG N ++ L P +PF+ V +
Sbjct: 572 GTGGAASKLVP--RSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIPFR-VGLYT 628
Query: 403 NYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVAD 447
S LD + L+V +D G P+L ATA V V + +
Sbjct: 629 GEISTT--RVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVE 671
>gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens]
Length = 950
Score = 796 bits (2055), Expect = 0.0
Identities = 397/534 (74%), Positives = 456/534 (85%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
M + RG LG+ LLL LLLLAAW+VGSGQLHYS+PEEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MDYHWRGELGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK HRDLLEV+LQNGILFVNSRIDREELC SAECSIHLE+I DRPLQVFHV+
Sbjct: 61 PRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+VKD+NDNPPVFR ++Q +F+ ESR+ +SRFP+EGA+DAD+GAN++LTY LS DYF L
Sbjct: 121 VEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFML 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DV + ++ +K + L LRK LDRE+ P HL LTATDGGKPEL GTV+LL+TVLDVNDNAP
Sbjct: 181 DVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
F+Q+ Y V + E NGT V LNASD DEG NG + +SF+S + + + F +D ++G
Sbjct: 241 TFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EI + LD+E+ Y+I + A DKG PPM+ HC VLV++LD NDN PE+A+TSL LP+R
Sbjct: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDA TVIALI+V+D DSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRE +S
Sbjct: 361 EDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATA +SVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGER+LS+Y+SVH ESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQ 534
Score = 420 bits (1079), Expect = e-117
Identities = 276/624 (44%), Positives = 332/624 (53%), Gaps = 65/624 (10%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
V V++ D NDN P + + E + + D D GAN +T +L P F
Sbjct: 336 VLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPF 395
Query: 179 SLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDN 238
L + S L L LDRE L++TA DGG P L T L + V DVNDN
Sbjct: 396 KLVSTFKNYYS----LVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDN 451
Query: 239 APLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGI--SRDIQEKFKVD 296
AP F Q Y V + E G + T++A DAD N V +S R + V
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVH 511
Query: 297 SSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL------ 350
+ SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L
Sbjct: 512 TESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVG 571
Query: 351 ---AVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLM-----PHVPFKLVSTFK 402
S +P V+A + D DSG N ++ L P +PF+ V +
Sbjct: 572 GTGGAASKLVP--RSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIPFR-VGLYT 628
Query: 403 NYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTV 462
S LD + L+V +D G P+L ATA V V + + A ++ V
Sbjct: 629 GEISTT--RVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRQSAGV 686
Query: 463 FVKENNPPGCHIFTVSARDADAQENAL-------VSYSLVERRVGERA-LSNYVSVHAES 514
E +++ + A A + L + S + G RA V A
Sbjct: 687 LGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSALPTEGGCRAGKPTLVCSSAVG 746
Query: 515 GKVYALQPLDH-------EELELLQFQPRQP-------------------------NPDW 542
Y+ Q + +L+ F P P NPDW
Sbjct: 747 SWSYSQQQPQRVCSGEGPPKTDLMAFSPCLPPDLGSVDVGEEQDLNVDHGLKPRQPNPDW 806
Query: 543 RYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNS 602
RYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNS
Sbjct: 807 RYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNS 866
Query: 603 WTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKK 662
WTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKK
Sbjct: 867 WTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKK 926
Query: 663 KKKKGNKTQEKKEKGNSTTDNSDQ 686
KKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 927 KKKKGNKTQEKKEKGNSTTDNSDQ 950
Score = 153 bits (386), Expect = 6e-37
Identities = 120/394 (30%), Positives = 182/394 (46%), Gaps = 32/394 (8%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPS----- 175
V V D+NDN P F E + I E+ + A+D D GAN ++Y+ +
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMV 289
Query: 176 -DYFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLD 234
D+FS+D + + +R LD E+ +L+ ATD G P + G +L+ +LD
Sbjct: 290 IDHFSIDRNTGE-------IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILD 342
Query: 235 VNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFK 294
NDN P + + E GT++ ++ +D D G NG+V S + + FK
Sbjct: 343 KNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFK 402
Query: 295 VDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTS 354
S + L LD E +YE+ V A D GSP + + V+V DVNDNAP A
Sbjct: 403 NYYS---LVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPE 459
Query: 355 LYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSA-- 412
+ ++E+ P I ++ D D+ N V+ SL+ + + +Y S+ +S
Sbjct: 460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGE--RSLSSYISVHTESGKV 517
Query: 413 -----LDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEY------- 460
LD E L + + V+ARD G P L + + V V D NDNAPA +P
Sbjct: 518 YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAA 577
Query: 461 TVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
+ V + G + V A DAD+ NA +SY L
Sbjct: 578 SKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYEL 611
>gi|9256586 protocadherin alpha 3 isoform 1 precursor [Homo sapiens]
Length = 950
Score = 795 bits (2054), Expect = 0.0
Identities = 404/534 (75%), Positives = 462/534 (86%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
M+FS R GA+ LLL LLLLAA EVGSGQLHYS+ EEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MLFSWREDPGAQCLLLSLLLLAASEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK H DLLEVNLQNGILFVNSRIDREELC SAECSIHLE+I DRPLQVFHVE
Sbjct: 61 PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVE 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+VKDINDN PVF + +FI ESR SRF +EGA+DADIG N+LLTY+L ++YF+L
Sbjct: 121 VEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYFTL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DV+ +DE KSL L L+K L+RE+TP+ +LL+TA DGGKPEL GT +L ITVLDVNDNAP
Sbjct: 181 DVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
F++ +Y+V LLE NGTLV T+NA+D DEGVN ++ +SF++ +S DI KF +D +G
Sbjct: 241 AFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
+I + +D+EE+KSYEIQV+A DKG+PPMS+HC VL++++D+NDN PEL + SL LP+
Sbjct: 301 QISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVL 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
ED+PLSTVIALI+VSDRDSG NGQVTCSL PHVPFKLVSTFKNYYSLVLDS LDRES+S
Sbjct: 361 EDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATA VSVEVADVNDNAPAF+Q EYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSAR 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGERALS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 391 bits (1004), Expect = e-108
Identities = 290/719 (40%), Positives = 368/719 (51%), Gaps = 90/719 (12%)
Query: 37 EEAKHGTFVGRV-AQDLGLELAELVPRLFR------VASKTHRDLLEVNLQNGILFVNSR 89
E A +GT V V A DL + + + F + SK H D + NG + V
Sbjct: 253 ENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPV-----NGQISVKGN 307
Query: 90 IDREELCQWSAECSIHLELI-ADRPLQVFHVEV--KVKDINDNPPVFRGREQIIFIPESR 146
ID EE S I +E P H V ++ DINDN P + + + E
Sbjct: 308 IDFEE----SKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDS 363
Query: 147 LLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLWLELRKYLDREETP 206
L++ + +D D G N +T +L+P F L + S L L LDRE
Sbjct: 364 PLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYS----LVLDSPLDRESVS 419
Query: 207 ELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNA 266
L++TA DGG P L T + + V DVNDNAP F Q+ Y V + E G + T++A
Sbjct: 420 AYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSA 479
Query: 267 SDADEGVNGEVVFSFDSGISRDIQEK-----FKVDSSSGEIRLIDKLDYEETKSYEIQVK 321
DAD N V +S + R + E+ V + SG++ + LD+EE + + QV
Sbjct: 480 RDADAQENALVSYSL---VERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVS 536
Query: 322 AVDKGSPPMSNHCKVLVKVLDVNDNAPEL---AVTSLYLPIREDAPLST----VIALITV 374
A D G PP+ ++ + V VLD NDNAP L V + + E P S V+A +
Sbjct: 537 ARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRA 596
Query: 375 SDRDSGANGQVTCSLMP-----HVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARD 429
D DSG N ++ L P +PF+ V + S ALD + L+V +D
Sbjct: 597 VDADSGYNAWLSYELQPGTGGARIPFR-VGLYTGEISTT--RALDEVDAPRHRLLVLVKD 653
Query: 430 GGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENAL 489
G PSL ATA V V + + A +Q E +++ + A A + L
Sbjct: 654 HGEPSLTATATVLVSLVESGQAPKASSQASAGATGPEAALVDVNVYLIVAICAVSSLLVL 713
Query: 490 VSYSLVERR-----------------VGERALSNYVSVHAESGKVYALQPLDHEELELLQ 532
R V A+ ++ +V + + L + +L+
Sbjct: 714 TLLLYTALRCSAPPTEGDCGPGKPTLVCSSAVGSWSYSQQRQQRVCSGEGL--PKTDLMA 771
Query: 533 FQPRQP------------NPDWRYSASLR---------AGMHSSVH----LEEAGILRAG 567
F P P + D SA R A + + +H LEEAGILRAG
Sbjct: 772 FSPSLPPCPISRDREEKQDVDVDLSAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAG 831
Query: 568 PGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIP 627
PGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIP
Sbjct: 832 PGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIP 891
Query: 628 GSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
GSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 892 GSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 950
Score = 150 bits (378), Expect = 5e-36
Identities = 132/473 (27%), Positives = 209/473 (44%), Gaps = 29/473 (6%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
+++ V D+NDN P F + + E+ + A D D G N + Y+ F
Sbjct: 228 LKITVLDVNDNAPAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYS------F 281
Query: 179 SLDVEASDELSK------SLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITV 232
+ D+ A D LSK + + ++ +D EE+ + + ATD G P + +L+ +
Sbjct: 282 NTDMSA-DILSKFHLDPVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEI 340
Query: 233 LDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK 292
+D+NDN P + +LE + T++ ++ SD D GVNG+V S + +
Sbjct: 341 VDINDNVPELVIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVST 400
Query: 293 FKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAV 352
FK S + L LD E +YE+ V A D GSP + V V+V DVNDNAP +
Sbjct: 401 FKNYYS---LVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQ 457
Query: 353 TSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPH-VPFKLVSTFKNYYS----L 407
+ + ++E+ P I ++ D D+ N V+ SL+ V + +S++ + ++ +
Sbjct: 458 SEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKV 517
Query: 408 VLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPE-------Y 460
LD E L + + V+ARD G P L + + V V D NDNAPA P
Sbjct: 518 YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAV 577
Query: 461 TVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYAL 520
+ V + G + V A DAD+ NA +SY L G R E AL
Sbjct: 578 SELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRAL 637
Query: 521 QPLDHEELELLQFQPRQPNPDWRYSASLRAGMHSSVHLEEAGI-LRAGPGGPD 572
+D LL P +A++ + S +A AG GP+
Sbjct: 638 DEVDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSQASAGATGPE 690
>gi|14165410 protocadherin alpha 3 isoform 2 precursor [Homo
sapiens]
Length = 824
Score = 795 bits (2054), Expect = 0.0
Identities = 404/534 (75%), Positives = 462/534 (86%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
M+FS R GA+ LLL LLLLAA EVGSGQLHYS+ EEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MLFSWREDPGAQCLLLSLLLLAASEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK H DLLEVNLQNGILFVNSRIDREELC SAECSIHLE+I DRPLQVFHVE
Sbjct: 61 PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVE 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+VKDINDN PVF + +FI ESR SRF +EGA+DADIG N+LLTY+L ++YF+L
Sbjct: 121 VEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYFTL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DV+ +DE KSL L L+K L+RE+TP+ +LL+TA DGGKPEL GT +L ITVLDVNDNAP
Sbjct: 181 DVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
F++ +Y+V LLE NGTLV T+NA+D DEGVN ++ +SF++ +S DI KF +D +G
Sbjct: 241 AFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
+I + +D+EE+KSYEIQV+A DKG+PPMS+HC VL++++D+NDN PEL + SL LP+
Sbjct: 301 QISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVL 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
ED+PLSTVIALI+VSDRDSG NGQVTCSL PHVPFKLVSTFKNYYSLVLDS LDRES+S
Sbjct: 361 EDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATA VSVEVADVNDNAPAF+Q EYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSAR 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGERALS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 151 bits (381), Expect = 2e-36
Identities = 142/448 (31%), Positives = 202/448 (45%), Gaps = 46/448 (10%)
Query: 37 EEAKHGTFVGRV-AQDLGLELAELVPRLFR------VASKTHRDLLEVNLQNGILFVNSR 89
E A +GT V V A DL + + + F + SK H D + NG + V
Sbjct: 253 ENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPV-----NGQISVKGN 307
Query: 90 IDREELCQWSAECSIHLELI-ADRPLQVFHVEV--KVKDINDNPPVFRGREQIIFIPESR 146
ID EE S I +E P H V ++ DINDN P + + + E
Sbjct: 308 IDFEE----SKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDS 363
Query: 147 LLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLWLELRKYLDREETP 206
L++ + +D D G N +T +L+P F L + S L L LDRE
Sbjct: 364 PLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYS----LVLDSPLDRESVS 419
Query: 207 ELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNA 266
L++TA DGG P L T + + V DVNDNAP F Q+ Y V + E G + T++A
Sbjct: 420 AYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSA 479
Query: 267 SDADEGVNGEVVFSFDSGISRDIQEK-----FKVDSSSGEIRLIDKLDYEETKSYEIQVK 321
DAD N V +S + R + E+ V + SG++ + LD+EE + + QV
Sbjct: 480 RDADAQENALVSYSL---VERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVS 536
Query: 322 AVDKGSPPMSNHCKVLVKVLDVNDNAPEL---AVTSLYLPIREDAPLST----VIALITV 374
A D G PP+ ++ + V VLD NDNAP L V + + E P S V+A +
Sbjct: 537 ARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRA 596
Query: 375 SDRDSGANGQVTCSLMP-----HVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARD 429
D DSG N ++ L P +PF+ V + S ALD + L+V +D
Sbjct: 597 VDADSGYNAWLSYELQPGTGGARIPFR-VGLYTGEISTT--RALDEVDAPRHRLLVLVKD 653
Query: 430 GGSPSLWATARVSVEVADVNDNAPAFAQ 457
G PSL ATA V V + + A +Q
Sbjct: 654 HGEPSLTATATVLVSLVESGQAPKASSQ 681
Score = 150 bits (378), Expect = 5e-36
Identities = 132/473 (27%), Positives = 209/473 (44%), Gaps = 29/473 (6%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
+++ V D+NDN P F + + E+ + A D D G N + Y+ F
Sbjct: 228 LKITVLDVNDNAPAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYS------F 281
Query: 179 SLDVEASDELSK------SLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITV 232
+ D+ A D LSK + + ++ +D EE+ + + ATD G P + +L+ +
Sbjct: 282 NTDMSA-DILSKFHLDPVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEI 340
Query: 233 LDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK 292
+D+NDN P + +LE + T++ ++ SD D GVNG+V S + +
Sbjct: 341 VDINDNVPELVIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVST 400
Query: 293 FKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAV 352
FK S + L LD E +YE+ V A D GSP + V V+V DVNDNAP +
Sbjct: 401 FKNYYS---LVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQ 457
Query: 353 TSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPH-VPFKLVSTFKNYYS----L 407
+ + ++E+ P I ++ D D+ N V+ SL+ V + +S++ + ++ +
Sbjct: 458 SEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKV 517
Query: 408 VLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPE-------Y 460
LD E L + + V+ARD G P L + + V V D NDNAPA P
Sbjct: 518 YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAV 577
Query: 461 TVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYAL 520
+ V + G + V A DAD+ NA +SY L G R E AL
Sbjct: 578 SELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRAL 637
Query: 521 QPLDHEELELLQFQPRQPNPDWRYSASLRAGMHSSVHLEEAGI-LRAGPGGPD 572
+D LL P +A++ + S +A AG GP+
Sbjct: 638 DEVDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSQASAGATGPE 690
>gi|14165413 protocadherin alpha 4 isoform 2 precursor [Homo
sapiens]
Length = 798
Score = 793 bits (2049), Expect = 0.0
Identities = 405/534 (75%), Positives = 455/534 (85%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
M FS G +R LLL LLLLAAWE G+GQLHYS+ EEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MEFSWGSGQESRRLLLLLLLLAAWEAGNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK LLEVNLQNGILFVNSRIDREELC+ SAECSIHLE+I DRPLQVFHV+
Sbjct: 61 PRLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVD 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+V+DINDNPPVF ++ + I ESR L+SRFP+EGA+DADIG NALLTY LSP++YFSL
Sbjct: 121 VEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
+ DEL K L L LRK LDREE PE+ L+LTATDGGKPEL GTV+LLITVLD NDNAP
Sbjct: 181 EKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
FD+ +Y+V LLE NGTLV LNASD DEG+NG++V+SF + IS +++ KF +D +G
Sbjct: 241 AFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
+I + +D+EE+KSYEI V+ +DKG P+S HC+V+V+V D NDN P+L SL LPIR
Sbjct: 301 QIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIR 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDAPL TVIALI+VSD+D G NG VTCSL HVPFKLVSTFKNYYSLVLDSALDRES+S
Sbjct: 361 EDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATA VSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA
Sbjct: 421 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGERALS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 145 bits (366), Expect = 1e-34
Identities = 130/405 (32%), Positives = 185/405 (45%), Gaps = 45/405 (11%)
Query: 66 VASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVF---HVEVK 122
V SK H D + G + V ID EE S I +E I L + V V+
Sbjct: 289 VKSKFHIDPI-----TGQIIVKGYIDFEE----SKSYEIIVEGIDKGQLPLSGHCRVIVE 339
Query: 123 VKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDV 182
V+D NDN P + + I E L + + +D D+G N L+T +L+ F L
Sbjct: 340 VEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVS 399
Query: 183 EASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLF 242
+ S L L LDRE L++TA DGG P L T + + V DVNDNAP F
Sbjct: 400 TFKNYYS----LVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAF 455
Query: 243 DQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK-----FKVDS 297
Q Y V + E G + T++A DAD N V +S + R + E+ V +
Sbjct: 456 AQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL---VERRVGERALSSYVSVHA 512
Query: 298 SSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL------- 350
SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L
Sbjct: 513 ESGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGG 572
Query: 351 ---AVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMP-----HVPFKLVSTFK 402
AV+ L + + V+A + D DSG N ++ L P +PF+ V +
Sbjct: 573 TGGAVSEL---VPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFR-VGLYT 628
Query: 403 NYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVAD 447
S ALD + L+V +D G P+L ATA V V + +
Sbjct: 629 GEISTT--RALDETDAPRHRLLVLVKDHGEPALTATATVLVSLVE 671
Score = 138 bits (348), Expect = 1e-32
Identities = 133/467 (28%), Positives = 203/467 (43%), Gaps = 21/467 (4%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIE-GAADADIGANALLTYTLSPSDYFS 179
+ V D NDN P F + + E+ + N I+ A+D D G N + Y+ S S
Sbjct: 230 ITVLDANDNAPAFDRTIYKVRLLEN-VPNGTLVIKLNASDLDEGLNGDIVYSFSND--IS 286
Query: 180 LDVEASDELSKSLW-LELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDN 238
+V++ + + ++ Y+D EE+ +++ D G+ L G +++ V D NDN
Sbjct: 287 PNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDN 346
Query: 239 APLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSS 298
P + + + E GT++ ++ SD D GVNG V S S + + FK S
Sbjct: 347 VPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYS 406
Query: 299 SGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLP 358
+ L LD E +YE+ V A D GSP + V V+V DVNDNAP A +
Sbjct: 407 ---LVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVF 463
Query: 359 IREDAPLSTVIALITVSDRDSGANGQVTCSLMPH-VPFKLVSTFKNYYS----LVLDSAL 413
++E+ P I ++ D D+ N V+ SL+ V + +S++ + ++ + L
Sbjct: 464 VKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPL 523
Query: 414 DRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPE-------YTVFVKE 466
D E L + + VTARD G P L + + V V D NDNAPA P + V
Sbjct: 524 DHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPW 583
Query: 467 NNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHE 526
+ G + V A DAD+ NA +SY L G R E AL D
Sbjct: 584 SVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAP 643
Query: 527 ELELLQFQPRQPNPDWRYSASLRAGMHSSVHLEEAGI-LRAGPGGPD 572
LL P +A++ + S +A G GPD
Sbjct: 644 RHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRALVGAVGPD 690
>gi|9256588 protocadherin alpha 4 isoform 1 precursor [Homo sapiens]
Length = 947
Score = 793 bits (2049), Expect = 0.0
Identities = 405/534 (75%), Positives = 455/534 (85%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
M FS G +R LLL LLLLAAWE G+GQLHYS+ EEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MEFSWGSGQESRRLLLLLLLLAAWEAGNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK LLEVNLQNGILFVNSRIDREELC+ SAECSIHLE+I DRPLQVFHV+
Sbjct: 61 PRLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVD 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+V+DINDNPPVF ++ + I ESR L+SRFP+EGA+DADIG NALLTY LSP++YFSL
Sbjct: 121 VEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
+ DEL K L L LRK LDREE PE+ L+LTATDGGKPEL GTV+LLITVLD NDNAP
Sbjct: 181 EKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
FD+ +Y+V LLE NGTLV LNASD DEG+NG++V+SF + IS +++ KF +D +G
Sbjct: 241 AFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
+I + +D+EE+KSYEI V+ +DKG P+S HC+V+V+V D NDN P+L SL LPIR
Sbjct: 301 QIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIR 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDAPL TVIALI+VSD+D G NG VTCSL HVPFKLVSTFKNYYSLVLDSALDRES+S
Sbjct: 361 EDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATA VSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA
Sbjct: 421 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGERALS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 319 bits (817), Expect = 6e-87
Identities = 152/153 (99%), Positives = 153/153 (100%)
Query: 534 QPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 593
+PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP
Sbjct: 795 KPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 854
Query: 594 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 653
VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG
Sbjct: 855 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 914
Query: 654 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 915 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 947
Score = 145 bits (366), Expect = 1e-34
Identities = 130/405 (32%), Positives = 185/405 (45%), Gaps = 45/405 (11%)
Query: 66 VASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVF---HVEVK 122
V SK H D + G + V ID EE S I +E I L + V V+
Sbjct: 289 VKSKFHIDPI-----TGQIIVKGYIDFEE----SKSYEIIVEGIDKGQLPLSGHCRVIVE 339
Query: 123 VKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDV 182
V+D NDN P + + I E L + + +D D+G N L+T +L+ F L
Sbjct: 340 VEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVS 399
Query: 183 EASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLF 242
+ S L L LDRE L++TA DGG P L T + + V DVNDNAP F
Sbjct: 400 TFKNYYS----LVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAF 455
Query: 243 DQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK-----FKVDS 297
Q Y V + E G + T++A DAD N V +S + R + E+ V +
Sbjct: 456 AQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL---VERRVGERALSSYVSVHA 512
Query: 298 SSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL------- 350
SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L
Sbjct: 513 ESGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGG 572
Query: 351 ---AVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMP-----HVPFKLVSTFK 402
AV+ L + + V+A + D DSG N ++ L P +PF+ V +
Sbjct: 573 TGGAVSEL---VPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFR-VGLYT 628
Query: 403 NYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVAD 447
S ALD + L+V +D G P+L ATA V V + +
Sbjct: 629 GEISTT--RALDETDAPRHRLLVLVKDHGEPALTATATVLVSLVE 671
Score = 138 bits (348), Expect = 1e-32
Identities = 133/467 (28%), Positives = 203/467 (43%), Gaps = 21/467 (4%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIE-GAADADIGANALLTYTLSPSDYFS 179
+ V D NDN P F + + E+ + N I+ A+D D G N + Y+ S S
Sbjct: 230 ITVLDANDNAPAFDRTIYKVRLLEN-VPNGTLVIKLNASDLDEGLNGDIVYSFSND--IS 286
Query: 180 LDVEASDELSKSLW-LELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDN 238
+V++ + + ++ Y+D EE+ +++ D G+ L G +++ V D NDN
Sbjct: 287 PNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDN 346
Query: 239 APLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSS 298
P + + + E GT++ ++ SD D GVNG V S S + + FK S
Sbjct: 347 VPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYS 406
Query: 299 SGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLP 358
+ L LD E +YE+ V A D GSP + V V+V DVNDNAP A +
Sbjct: 407 ---LVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVF 463
Query: 359 IREDAPLSTVIALITVSDRDSGANGQVTCSLMPH-VPFKLVSTFKNYYS----LVLDSAL 413
++E+ P I ++ D D+ N V+ SL+ V + +S++ + ++ + L
Sbjct: 464 VKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPL 523
Query: 414 DRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPE-------YTVFVKE 466
D E L + + VTARD G P L + + V V D NDNAPA P + V
Sbjct: 524 DHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPW 583
Query: 467 NNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHE 526
+ G + V A DAD+ NA +SY L G R E AL D
Sbjct: 584 SVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAP 643
Query: 527 ELELLQFQPRQPNPDWRYSASLRAGMHSSVHLEEAGI-LRAGPGGPD 572
LL P +A++ + S +A G GPD
Sbjct: 644 RHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRALVGAVGPD 690
>gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo
sapiens]
Length = 807
Score = 792 bits (2045), Expect = 0.0
Identities = 404/534 (75%), Positives = 455/534 (85%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
M+ S +GG R LLLWLL+LAAWE GSGQLHYS+PEEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MLSSWQGGPRPRQLLLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK H DLLEVNLQNGILFVNSRIDREELC SAECSIHLE+I DRPLQVFHVE
Sbjct: 61 PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVE 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
VKV+DINDNPP+F ++ I I ESR +RFP++GA+DADIG N+ LTY L P+DYF+L
Sbjct: 121 VKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
D + S E SL L LRK LDREE E LLLTA+DGGKPEL GTV+LLIT+LDVNDNAP
Sbjct: 181 DAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
F Q+VY+V +LE NGTLV LNA+D D+G NG++V+SF + + F ++ ++G
Sbjct: 241 EFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EIR KLD+EE K YEI V+AVDKG+ PM+ HC +LV+VLDVNDNAPE+ +TSL LPIR
Sbjct: 301 EIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIR 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
ED S +IALI+VSDRDSG+NGQVTC+L PHVPFKLVST+KNYYSLVLDSALDRES+S
Sbjct: 361 EDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATA VSV VADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA+
Sbjct: 421 YELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQ 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGERALS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 139 bits (349), Expect = 1e-32
Identities = 111/344 (32%), Positives = 160/344 (46%), Gaps = 27/344 (7%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+V D+NDN P + I E ++ + +D D G+N +T TL+P F L
Sbjct: 338 VEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKL 397
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
+ S L L LDRE L++TA DGG P L T + + V DVNDNAP
Sbjct: 398 VSTYKNYYS----LVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAP 453
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK-----FKV 295
F Q Y V + E G + T++A DAD N V +S + R + E+ V
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSL---VERRVGERALSSYVSV 510
Query: 296 DSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL---AV 352
+ SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L
Sbjct: 511 HAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGA 570
Query: 353 TSLYLPIREDAPLST----VIALITVSDRDSGANGQVTCSLM-----PHVPFKLVSTFKN 403
S + E P S V+A + D DSG N ++ L +PF+ V +
Sbjct: 571 GSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFR-VGLYTG 629
Query: 404 YYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVAD 447
S LD + L+V +D G P+L ATA V + + +
Sbjct: 630 EISTT--RPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVE 671
Score = 138 bits (348), Expect = 1e-32
Identities = 118/420 (28%), Positives = 187/420 (44%), Gaps = 27/420 (6%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLS----PSD 176
+ + D+NDN P F + + E+ + A D D G N + Y+ P+
Sbjct: 230 ITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAV 289
Query: 177 YFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVN 236
++ + ++ ++ + LD EE + + A D G + G LL+ VLDVN
Sbjct: 290 VYAFTINPNNGEIRT-----KGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVN 344
Query: 237 DNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVD 296
DNAP + + E T ++ ++ SD D G NG+V + + + +K
Sbjct: 345 DNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNY 404
Query: 297 SSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLY 356
S + L LD E +YE+ V A D GSP + V V V DVNDNAP A
Sbjct: 405 YS---LVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYT 461
Query: 357 LPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPH-VPFKLVSTFKNYYS----LVLDS 411
+ ++E+ P I ++ D D+ N V+ SL+ V + +S++ + ++ +
Sbjct: 462 VFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQ 521
Query: 412 ALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQP-------EYTVFV 464
LD E L + + V+ARD G P L + + V V D NDNAPA P + +
Sbjct: 522 PLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELM 581
Query: 465 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLD 524
+ G + V A DAD+ NA +SY L VG R V +G++ +PLD
Sbjct: 582 PRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARI---PFRVGLYTGEISTTRPLD 638
>gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo
sapiens]
Length = 950
Score = 792 bits (2045), Expect = 0.0
Identities = 404/534 (75%), Positives = 455/534 (85%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
M+ S +GG R LLLWLL+LAAWE GSGQLHYS+PEEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MLSSWQGGPRPRQLLLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK H DLLEVNLQNGILFVNSRIDREELC SAECSIHLE+I DRPLQVFHVE
Sbjct: 61 PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVE 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
VKV+DINDNPP+F ++ I I ESR +RFP++GA+DADIG N+ LTY L P+DYF+L
Sbjct: 121 VKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
D + S E SL L LRK LDREE E LLLTA+DGGKPEL GTV+LLIT+LDVNDNAP
Sbjct: 181 DAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
F Q+VY+V +LE NGTLV LNA+D D+G NG++V+SF + + F ++ ++G
Sbjct: 241 EFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EIR KLD+EE K YEI V+AVDKG+ PM+ HC +LV+VLDVNDNAPE+ +TSL LPIR
Sbjct: 301 EIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIR 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
ED S +IALI+VSDRDSG+NGQVTC+L PHVPFKLVST+KNYYSLVLDSALDRES+S
Sbjct: 361 EDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATA VSV VADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA+
Sbjct: 421 YELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQ 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGERALS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 320 bits (820), Expect = 3e-87
Identities = 155/161 (96%), Positives = 158/161 (98%), Gaps = 1/161 (0%)
Query: 526 EELELLQFQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEP 585
E+ E L+ +PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEP
Sbjct: 791 EDSECLK-EPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEP 849
Query: 586 EAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQID 645
EAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQID
Sbjct: 850 EAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQID 909
Query: 646 KSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
KSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 910 KSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 950
Score = 139 bits (349), Expect = 1e-32
Identities = 111/344 (32%), Positives = 160/344 (46%), Gaps = 27/344 (7%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+V D+NDN P + I E ++ + +D D G+N +T TL+P F L
Sbjct: 338 VEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKL 397
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
+ S L L LDRE L++TA DGG P L T + + V DVNDNAP
Sbjct: 398 VSTYKNYYS----LVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAP 453
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK-----FKV 295
F Q Y V + E G + T++A DAD N V +S + R + E+ V
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSL---VERRVGERALSSYVSV 510
Query: 296 DSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL---AV 352
+ SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L
Sbjct: 511 HAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGA 570
Query: 353 TSLYLPIREDAPLST----VIALITVSDRDSGANGQVTCSLM-----PHVPFKLVSTFKN 403
S + E P S V+A + D DSG N ++ L +PF+ V +
Sbjct: 571 GSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFR-VGLYTG 629
Query: 404 YYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVAD 447
S LD + L+V +D G P+L ATA V + + +
Sbjct: 630 EISTT--RPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVE 671
Score = 138 bits (348), Expect = 1e-32
Identities = 118/420 (28%), Positives = 187/420 (44%), Gaps = 27/420 (6%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLS----PSD 176
+ + D+NDN P F + + E+ + A D D G N + Y+ P+
Sbjct: 230 ITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAV 289
Query: 177 YFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVN 236
++ + ++ ++ + LD EE + + A D G + G LL+ VLDVN
Sbjct: 290 VYAFTINPNNGEIRT-----KGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVN 344
Query: 237 DNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVD 296
DNAP + + E T ++ ++ SD D G NG+V + + + +K
Sbjct: 345 DNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNY 404
Query: 297 SSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLY 356
S + L LD E +YE+ V A D GSP + V V V DVNDNAP A
Sbjct: 405 YS---LVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYT 461
Query: 357 LPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPH-VPFKLVSTFKNYYS----LVLDS 411
+ ++E+ P I ++ D D+ N V+ SL+ V + +S++ + ++ +
Sbjct: 462 VFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQ 521
Query: 412 ALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQP-------EYTVFV 464
LD E L + + V+ARD G P L + + V V D NDNAPA P + +
Sbjct: 522 PLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELM 581
Query: 465 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLD 524
+ G + V A DAD+ NA +SY L VG R V +G++ +PLD
Sbjct: 582 PRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARI---PFRVGLYTGEISTTRPLD 638
>gi|7662068 protocadherin alpha 9 isoform 2 precursor [Homo sapiens]
Length = 842
Score = 791 bits (2042), Expect = 0.0
Identities = 399/534 (74%), Positives = 461/534 (86%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
M++S RG + LLL LL+LA W VGSGQLHYS+PEEA+HGTFVGR+AQDLGLELAELV
Sbjct: 1 MLYSSRGDPEGQPLLLSLLILAMWVVGSGQLHYSVPEEAEHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLF++ SK DLLEVNLQNGILFVNSRIDREELC SAECSIHLE+I DRPLQVFHV+
Sbjct: 61 PRLFQLDSKGRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+VKDINDNPPVF ++ +FI ESR L+SRFP+EGA+DADIG NALLTY LSP++YF L
Sbjct: 121 VEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DV S++ K L L LRK LDREETPELHLLLTATDGGKPEL GTV+LLITVLD NDNAP
Sbjct: 181 DVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
+FD+ +Y V L E + GTLV NASD DEG+NG++++SF S +S DI+ KF +D SG
Sbjct: 241 VFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
I +I +D+EE+++++I V+AVDKG PP++ HC +LV+V+DVNDNAP+L + +L +P++
Sbjct: 301 AITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVK 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDA L TVIALI+V D D+ ANGQVTCSL PHVPFKLVST+KNYYSLVLD ALDRES+S
Sbjct: 361 EDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAR 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERR+GER+LS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 147 bits (370), Expect = 4e-35
Identities = 132/433 (30%), Positives = 200/433 (46%), Gaps = 37/433 (8%)
Query: 84 LFVNSRIDREELCQWSAECSIHLELIAD---RPLQVFHVE--VKVKDINDNPPVFRGREQ 138
L + +DREE + +HL L A +P V+ + V D NDN PVF
Sbjct: 194 LVLRKLLDREETPE------LHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 247
Query: 139 IIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEAS---DELSKSLWLE 195
+ +PE+ + + A+D D G N + Y+ S S D+++ D LS ++
Sbjct: 248 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD--VSPDIKSKFHMDPLSGAI--T 303
Query: 196 LRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETT 255
+ ++D EE+ + + A D G P L G LL+ V+DVNDNAP V + E
Sbjct: 304 VIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDA 363
Query: 256 ANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKS 315
GT++ ++ D D NG+V S + + +K S + L LD E +
Sbjct: 364 QLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYS---LVLDRALDRESVSA 420
Query: 316 YEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVS 375
YE+ V A D GSP + +V V+V DVNDNAP A + + ++E+ P I ++
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAR 480
Query: 376 DRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSA-------LDRESLSVYELVVTAR 428
D D+ N V+ SL+ + + +Y S+ +S LD E L + + V+AR
Sbjct: 481 DADAQENALVSYSLVERRLGE--RSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSAR 538
Query: 429 DGGSPSLWATARVSVEVADVNDNAPAFAQPE-------YTVFVKENNPPGCHIFTVSARD 481
D G P L + + V V D NDNAPA P + V + G + V A D
Sbjct: 539 DAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVD 598
Query: 482 ADAQENALVSYSL 494
AD+ NA +SY L
Sbjct: 599 ADSGYNAWLSYEL 611
Score = 144 bits (364), Expect = 2e-34
Identities = 110/344 (31%), Positives = 158/344 (45%), Gaps = 27/344 (7%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+V D+NDN P + + + E L + + D D AN +T +L+P F L
Sbjct: 338 VEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKL 397
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
+ S L L + LDRE L++TA DGG P L T + + V DVNDNAP
Sbjct: 398 VSTYKNYYS----LVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAP 453
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGI--SRDIQEKFKVDSS 298
F Q+ Y V + E G + T++A DAD N V +S R + V +
Sbjct: 454 AFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAE 513
Query: 299 SGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL-------- 350
SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGT 573
Query: 351 --AVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPH-----VPFKLVSTFKN 403
AV+ + L V+ + D DSG N ++ L P +PF+ V +
Sbjct: 574 DGAVSEMVL---RSVGAGVVVGKVRAVDADSGYNAWLSYELQPETASASIPFR-VGLYTG 629
Query: 404 YYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVAD 447
S ALD L+V +D G P+L ATA V V + +
Sbjct: 630 EISTT--RALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVE 671
>gi|14165425 protocadherin alpha 9 isoform 1 precursor [Homo
sapiens]
Length = 950
Score = 791 bits (2042), Expect = 0.0
Identities = 399/534 (74%), Positives = 461/534 (86%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
M++S RG + LLL LL+LA W VGSGQLHYS+PEEA+HGTFVGR+AQDLGLELAELV
Sbjct: 1 MLYSSRGDPEGQPLLLSLLILAMWVVGSGQLHYSVPEEAEHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLF++ SK DLLEVNLQNGILFVNSRIDREELC SAECSIHLE+I DRPLQVFHV+
Sbjct: 61 PRLFQLDSKGRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+VKDINDNPPVF ++ +FI ESR L+SRFP+EGA+DADIG NALLTY LSP++YF L
Sbjct: 121 VEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DV S++ K L L LRK LDREETPELHLLLTATDGGKPEL GTV+LLITVLD NDNAP
Sbjct: 181 DVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
+FD+ +Y V L E + GTLV NASD DEG+NG++++SF S +S DI+ KF +D SG
Sbjct: 241 VFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
I +I +D+EE+++++I V+AVDKG PP++ HC +LV+V+DVNDNAP+L + +L +P++
Sbjct: 301 AITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVK 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDA L TVIALI+V D D+ ANGQVTCSL PHVPFKLVST+KNYYSLVLD ALDRES+S
Sbjct: 361 EDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAR 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERR+GER+LS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 319 bits (817), Expect = 6e-87
Identities = 152/153 (99%), Positives = 153/153 (100%)
Query: 534 QPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 593
+PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP
Sbjct: 798 KPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 857
Query: 594 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 653
VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG
Sbjct: 858 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 917
Query: 654 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 918 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 950
Score = 147 bits (370), Expect = 4e-35
Identities = 132/433 (30%), Positives = 200/433 (46%), Gaps = 37/433 (8%)
Query: 84 LFVNSRIDREELCQWSAECSIHLELIAD---RPLQVFHVE--VKVKDINDNPPVFRGREQ 138
L + +DREE + +HL L A +P V+ + V D NDN PVF
Sbjct: 194 LVLRKLLDREETPE------LHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 247
Query: 139 IIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEAS---DELSKSLWLE 195
+ +PE+ + + A+D D G N + Y+ S S D+++ D LS ++
Sbjct: 248 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD--VSPDIKSKFHMDPLSGAI--T 303
Query: 196 LRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETT 255
+ ++D EE+ + + A D G P L G LL+ V+DVNDNAP V + E
Sbjct: 304 VIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDA 363
Query: 256 ANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKS 315
GT++ ++ D D NG+V S + + +K S + L LD E +
Sbjct: 364 QLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYS---LVLDRALDRESVSA 420
Query: 316 YEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVS 375
YE+ V A D GSP + +V V+V DVNDNAP A + + ++E+ P I ++
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAR 480
Query: 376 DRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSA-------LDRESLSVYELVVTAR 428
D D+ N V+ SL+ + + +Y S+ +S LD E L + + V+AR
Sbjct: 481 DADAQENALVSYSLVERRLGE--RSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSAR 538
Query: 429 DGGSPSLWATARVSVEVADVNDNAPAFAQPE-------YTVFVKENNPPGCHIFTVSARD 481
D G P L + + V V D NDNAPA P + V + G + V A D
Sbjct: 539 DAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVD 598
Query: 482 ADAQENALVSYSL 494
AD+ NA +SY L
Sbjct: 599 ADSGYNAWLSYEL 611
>gi|14165387 protocadherin alpha 11 isoform 2 precursor [Homo
sapiens]
Length = 810
Score = 788 bits (2036), Expect = 0.0
Identities = 406/530 (76%), Positives = 453/530 (85%), Gaps = 1/530 (0%)
Query: 5 RRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLF 64
+R GLG L LWLLLL WEVGSGQLHYS+ EEAKHGTFVGR+AQDLGLELAELV RLF
Sbjct: 5 QRRGLGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVQRLF 64
Query: 65 RVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKVK 124
RVASKTH DLLEVNLQNGILFVNSRIDREELC SAECSIHLE+I DRPLQVFHV V+VK
Sbjct: 65 RVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVK 124
Query: 125 DINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEA 184
DINDNPPVF REQ + I ES+ +SRFP+EGA+DADI NALLTY LS ++YFSLD
Sbjct: 125 DINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSLDSPT 184
Query: 185 SDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQ 244
+ + K L L L+K LDRE+TPEL+LLLTATDGGKPEL GTV LL+ VLDVNDN P FD+
Sbjct: 185 NGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDK 244
Query: 245 AVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRL 304
+ Y+V L+E A TLV LNA+D DEGVNGEV +S S I + + F +D ++GE+R+
Sbjct: 245 SEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNNGEVRV 303
Query: 305 IDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAP 364
LDYEE K Y+I+V+A DKG+PPM+ HC V V++LD NDN+PE+AVTSL LP+REDA
Sbjct: 304 NGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVREDAQ 363
Query: 365 LSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELV 424
STVIALI+VSDRDSG NGQVTCSL PHVPFKLVSTFKNYYSLVLDSALDRE++ YELV
Sbjct: 364 PSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAYELV 423
Query: 425 VTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADA 484
VTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADA
Sbjct: 424 VTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADA 483
Query: 485 QENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
QENALVSYSLVERR+G+RALS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 484 QENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
Score = 145 bits (367), Expect = 9e-35
Identities = 124/392 (31%), Positives = 178/392 (45%), Gaps = 26/392 (6%)
Query: 72 RDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFH--VEVKVKDINDN 129
R L ++ NG + VN +D EE + E + P H V V++ D NDN
Sbjct: 289 RHLFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDK---GTPPMAGHCTVWVEILDTNDN 345
Query: 130 PPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELS 189
P + + E ++ + +D D G N +T +L+P F L + S
Sbjct: 346 SPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYS 405
Query: 190 KSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRV 249
L L LDRE L++TA DGG P L T + + V DVNDNAP F Q Y V
Sbjct: 406 ----LVLDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTV 461
Query: 250 HLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGI--SRDIQEKFKVDSSSGEIRLIDK 307
+ E G + T++A DAD N V +S R + V + SG++ +
Sbjct: 462 FVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQP 521
Query: 308 LDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVT---SLYLPIREDAP 364
LD+EE + + QV A D G PP+S++ + V VLD NDNAP L T S + + P
Sbjct: 522 LDHEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVP 581
Query: 365 LST----VIALITVSDRDSGANGQVTCSLMP-----HVPFKLVSTFKNYYSLVLDSALDR 415
S V+A + D DSG N ++ L P +PF+ V + S ALD
Sbjct: 582 RSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSRIPFR-VGLYTGEISTT--RALDE 638
Query: 416 ESLSVYELVVTARDGGSPSLWATARVSVEVAD 447
+ L+V +D G P+L ATA V V + +
Sbjct: 639 ADSPRHRLLVLVKDHGEPALTATATVLVSLVE 670
Score = 144 bits (362), Expect = 4e-34
Identities = 119/399 (29%), Positives = 181/399 (45%), Gaps = 27/399 (6%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTL-----SPS 175
V+V D+NDN P F E + + E+ + A D D G N +TY+L +
Sbjct: 230 VQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGR 289
Query: 176 DYFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDV 235
F+LD + + + LD EE + + ATD G P + G + + +LD
Sbjct: 290 HLFTLDQNNGE-------VRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDT 342
Query: 236 NDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKV 295
NDN+P + + E T++ ++ SD D GVNG+V S + + FK
Sbjct: 343 NDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKN 402
Query: 296 DSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSL 355
S + L LD E +YE+ V A D GSP + +V V+V DVNDNAP A
Sbjct: 403 YYS---LVLDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEY 459
Query: 356 YLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPH-VPFKLVSTFKNYYS----LVLD 410
+ ++E+ P I ++ D D+ N V+ SL+ + + +S++ + ++ +
Sbjct: 460 TVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYAL 519
Query: 411 SALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAF-------AQPEYTVF 463
LD E L + + V+ARD G P L + + V V D NDNAPA A
Sbjct: 520 QPLDHEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKL 579
Query: 464 VKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER 502
V + G + V A DAD+ NA +SY L G R
Sbjct: 580 VPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSR 618
>gi|9256576 protocadherin alpha 11 isoform 1 precursor [Homo
sapiens]
Length = 949
Score = 788 bits (2036), Expect = 0.0
Identities = 406/530 (76%), Positives = 453/530 (85%), Gaps = 1/530 (0%)
Query: 5 RRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLF 64
+R GLG L LWLLLL WEVGSGQLHYS+ EEAKHGTFVGR+AQDLGLELAELV RLF
Sbjct: 5 QRRGLGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVQRLF 64
Query: 65 RVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKVK 124
RVASKTH DLLEVNLQNGILFVNSRIDREELC SAECSIHLE+I DRPLQVFHV V+VK
Sbjct: 65 RVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVK 124
Query: 125 DINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEA 184
DINDNPPVF REQ + I ES+ +SRFP+EGA+DADI NALLTY LS ++YFSLD
Sbjct: 125 DINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSLDSPT 184
Query: 185 SDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQ 244
+ + K L L L+K LDRE+TPEL+LLLTATDGGKPEL GTV LL+ VLDVNDN P FD+
Sbjct: 185 NGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDK 244
Query: 245 AVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRL 304
+ Y+V L+E A TLV LNA+D DEGVNGEV +S S I + + F +D ++GE+R+
Sbjct: 245 SEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNNGEVRV 303
Query: 305 IDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAP 364
LDYEE K Y+I+V+A DKG+PPM+ HC V V++LD NDN+PE+AVTSL LP+REDA
Sbjct: 304 NGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVREDAQ 363
Query: 365 LSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELV 424
STVIALI+VSDRDSG NGQVTCSL PHVPFKLVSTFKNYYSLVLDSALDRE++ YELV
Sbjct: 364 PSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAYELV 423
Query: 425 VTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADA 484
VTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADA
Sbjct: 424 VTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADA 483
Query: 485 QENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
QENALVSYSLVERR+G+RALS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 484 QENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
Score = 320 bits (821), Expect = 2e-87
Identities = 153/153 (100%), Positives = 153/153 (100%)
Query: 534 QPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 593
QPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP
Sbjct: 797 QPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 856
Query: 594 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 653
VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG
Sbjct: 857 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 916
Query: 654 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 917 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 949
Score = 144 bits (362), Expect = 4e-34
Identities = 119/399 (29%), Positives = 181/399 (45%), Gaps = 27/399 (6%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTL-----SPS 175
V+V D+NDN P F E + + E+ + A D D G N +TY+L +
Sbjct: 230 VQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGR 289
Query: 176 DYFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDV 235
F+LD + + + LD EE + + ATD G P + G + + +LD
Sbjct: 290 HLFTLDQNNGE-------VRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDT 342
Query: 236 NDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKV 295
NDN+P + + E T++ ++ SD D GVNG+V S + + FK
Sbjct: 343 NDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKN 402
Query: 296 DSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSL 355
S + L LD E +YE+ V A D GSP + +V V+V DVNDNAP A
Sbjct: 403 YYS---LVLDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEY 459
Query: 356 YLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPH-VPFKLVSTFKNYYS----LVLD 410
+ ++E+ P I ++ D D+ N V+ SL+ + + +S++ + ++ +
Sbjct: 460 TVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYAL 519
Query: 411 SALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAF-------AQPEYTVF 463
LD E L + + V+ARD G P L + + V V D NDNAPA A
Sbjct: 520 QPLDHEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKL 579
Query: 464 VKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER 502
V + G + V A DAD+ NA +SY L G R
Sbjct: 580 VPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSR 618
>gi|14165419 protocadherin alpha 7 isoform 2 precursor [Homo
sapiens]
Length = 789
Score = 786 bits (2029), Expect = 0.0
Identities = 398/525 (75%), Positives = 450/525 (85%)
Query: 10 GARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASK 69
G R LLL++++LAAWE G GQLHYS+PEEAKHG FVGR+AQDLGLELAELVPRLFR K
Sbjct: 10 GGRHLLLFIIILAAWEAGRGQLHYSVPEEAKHGNFVGRIAQDLGLELAELVPRLFRAVCK 69
Query: 70 THRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKVKDINDN 129
DLLEVNLQNGILFVNSRIDREELC SAECSIHLE+I +RPLQVFHV+V+VKDINDN
Sbjct: 70 FRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDN 129
Query: 130 PPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELS 189
PPVF ++ +FI ESR L+SRFP+EGA+DADIG NALLTY LSP++YF LDV S++
Sbjct: 130 PPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQV 189
Query: 190 KSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRV 249
K L L LRK LDREETPELHLLLTATDGGKPEL GTV+LLITVLD NDNAP+FD+ +Y V
Sbjct: 190 KPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTV 249
Query: 250 HLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLD 309
L E + GTLV NASD DEG+NG++++SF S +S DI+ KF +D SG I +I +D
Sbjct: 250 KLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMD 309
Query: 310 YEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVI 369
+EE+++++I V+AVDKG PP++ HC VLV+V+DVNDNAP+L +TSL LPI EDA TVI
Sbjct: 310 FEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVI 369
Query: 370 ALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARD 429
LI+V DRD G NGQVTCSL P VPFKLVSTFKNYYSLVLDSALDRES+S YELVVTARD
Sbjct: 370 TLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD 429
Query: 430 GGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENAL 489
GGSPSLWATA VSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA DADAQ+NAL
Sbjct: 430 GGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNAL 489
Query: 490 VSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
VSYSLVE RVGERALS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 490 VSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 151 bits (381), Expect = 2e-36
Identities = 133/431 (30%), Positives = 202/431 (46%), Gaps = 33/431 (7%)
Query: 84 LFVNSRIDREELCQWSAECSIHLELIAD---RPLQVFHVE--VKVKDINDNPPVFRGREQ 138
L + +DREE + +HL L A +P V+ + V D NDN PVF
Sbjct: 194 LVLRKLLDREETPE------LHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 247
Query: 139 IIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEAS---DELSKSLWLE 195
+ +PE+ + + A+D D G N + Y+ S S D+++ D LS ++
Sbjct: 248 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD--VSPDIKSKFHMDPLSGAI--T 303
Query: 196 LRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETT 255
+ ++D EE+ + + A D G P L G +L+ V+DVNDNAP + + E
Sbjct: 304 VIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDA 363
Query: 256 ANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKS 315
GT++T ++ D D GVNG+V S + + FK S + L LD E +
Sbjct: 364 QPGTVITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYS---LVLDSALDRESVSA 420
Query: 316 YEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVS 375
YE+ V A D GSP + V V+V DVNDNAP A + ++E+ P I ++
Sbjct: 421 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAG 480
Query: 376 DRDSGANGQVTCSLMP-HVPFKLVSTFKNYYS----LVLDSALDRESLSVYELVVTARDG 430
D D+ N V+ SL+ V + +S++ + ++ + LD E L + + V+ARD
Sbjct: 481 DADAQKNALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDA 540
Query: 431 GSPSLWATARVSVEVADVNDNAPAFAQPE-------YTVFVKENNPPGCHIFTVSARDAD 483
G P L + + V V D NDNAPA P V + G + V A DAD
Sbjct: 541 GVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDAD 600
Query: 484 AQENALVSYSL 494
+ NA +SY L
Sbjct: 601 SGYNAWLSYEL 611
Score = 148 bits (374), Expect = 1e-35
Identities = 116/343 (33%), Positives = 159/343 (46%), Gaps = 21/343 (6%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
V V+V D+NDN P + IPE + + D D G N +T +L+P F
Sbjct: 336 VLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPF 395
Query: 179 SLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDN 238
L + S L L LDRE L++TA DGG P L T + + V DVNDN
Sbjct: 396 KLVSTFKNYYS----LVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDN 451
Query: 239 APLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGI--SRDIQEKFKVD 296
AP F Q Y V + E G + T++A DAD N V +S R + V
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVH 511
Query: 297 SSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL---AVT 353
+ SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L V
Sbjct: 512 AESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVG 571
Query: 354 SLYLPIREDAPLST----VIALITVSDRDSGANGQVTCSLMP-----HVPFKLVSTFKNY 404
+RE P S V+A + D DSG N ++ L P +PF+ V +
Sbjct: 572 GTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFR-VGLYTGE 630
Query: 405 YSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVAD 447
S ALD + L+V +D G PSL ATA V V + +
Sbjct: 631 ISTT--RALDETDAPRHRLLVLVKDHGEPSLTATATVLVSLVE 671
>gi|9256594 protocadherin alpha 7 isoform 1 precursor [Homo sapiens]
Length = 937
Score = 786 bits (2029), Expect = 0.0
Identities = 398/525 (75%), Positives = 450/525 (85%)
Query: 10 GARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASK 69
G R LLL++++LAAWE G GQLHYS+PEEAKHG FVGR+AQDLGLELAELVPRLFR K
Sbjct: 10 GGRHLLLFIIILAAWEAGRGQLHYSVPEEAKHGNFVGRIAQDLGLELAELVPRLFRAVCK 69
Query: 70 THRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKVKDINDN 129
DLLEVNLQNGILFVNSRIDREELC SAECSIHLE+I +RPLQVFHV+V+VKDINDN
Sbjct: 70 FRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDN 129
Query: 130 PPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELS 189
PPVF ++ +FI ESR L+SRFP+EGA+DADIG NALLTY LSP++YF LDV S++
Sbjct: 130 PPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQV 189
Query: 190 KSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRV 249
K L L LRK LDREETPELHLLLTATDGGKPEL GTV+LLITVLD NDNAP+FD+ +Y V
Sbjct: 190 KPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTV 249
Query: 250 HLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLD 309
L E + GTLV NASD DEG+NG++++SF S +S DI+ KF +D SG I +I +D
Sbjct: 250 KLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMD 309
Query: 310 YEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVI 369
+EE+++++I V+AVDKG PP++ HC VLV+V+DVNDNAP+L +TSL LPI EDA TVI
Sbjct: 310 FEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVI 369
Query: 370 ALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARD 429
LI+V DRD G NGQVTCSL P VPFKLVSTFKNYYSLVLDSALDRES+S YELVVTARD
Sbjct: 370 TLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD 429
Query: 430 GGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENAL 489
GGSPSLWATA VSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA DADAQ+NAL
Sbjct: 430 GGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNAL 489
Query: 490 VSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
VSYSLVE RVGERALS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 490 VSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 442 bits (1138), Expect = e-124
Identities = 286/609 (46%), Positives = 340/609 (55%), Gaps = 48/609 (7%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
V V+V D+NDN P + IPE + + D D G N +T +L+P F
Sbjct: 336 VLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPF 395
Query: 179 SLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDN 238
L + S L L LDRE L++TA DGG P L T + + V DVNDN
Sbjct: 396 KLVSTFKNYYS----LVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDN 451
Query: 239 APLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGI--SRDIQEKFKVD 296
AP F Q Y V + E G + T++A DAD N V +S R + V
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVH 511
Query: 297 SSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELA---VT 353
+ SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L V
Sbjct: 512 AESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVG 571
Query: 354 SLYLPIREDAPLST----VIALITVSDRDSGANGQVTCSLMP-----HVPFKLVSTFKNY 404
+RE P S V+A + D DSG N ++ L P +PF+ V +
Sbjct: 572 GTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFR-VGLYTGE 630
Query: 405 YSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFV 464
S ALD + L+V +D G PSL ATA V V + + A ++ +
Sbjct: 631 ISTT--RALDETDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSRASLGIAG 688
Query: 465 KENNPPGCHIFTVSAR-------------------DADAQENA--LVSYSLV-ERRVGER 502
E +++ + A A + E A LV +LV VG
Sbjct: 689 PETELVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPSSEGACSLVKPTLVCSSAVGSW 748
Query: 503 ALSNYVSVHAESGKVYALQPLDHEELELLQF-----QPRQPNPDWRYSASLRAGMHSSVH 557
+ S SG+ L L Q PRQPNPDWRYSASLRAGMHSSVH
Sbjct: 749 SFSQQRRQRVCSGEGPPKTDLMAFSPSLPQGPSSTDNPRQPNPDWRYSASLRAGMHSSVH 808
Query: 558 LEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGP 617
LEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGP
Sbjct: 809 LEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGP 868
Query: 618 GELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKG 677
GELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKG
Sbjct: 869 GELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKG 928
Query: 678 NSTTDNSDQ 686
NSTTDNSDQ
Sbjct: 929 NSTTDNSDQ 937
Score = 151 bits (381), Expect = 2e-36
Identities = 133/431 (30%), Positives = 202/431 (46%), Gaps = 33/431 (7%)
Query: 84 LFVNSRIDREELCQWSAECSIHLELIAD---RPLQVFHVE--VKVKDINDNPPVFRGREQ 138
L + +DREE + +HL L A +P V+ + V D NDN PVF
Sbjct: 194 LVLRKLLDREETPE------LHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 247
Query: 139 IIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEAS---DELSKSLWLE 195
+ +PE+ + + A+D D G N + Y+ S S D+++ D LS ++
Sbjct: 248 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD--VSPDIKSKFHMDPLSGAI--T 303
Query: 196 LRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETT 255
+ ++D EE+ + + A D G P L G +L+ V+DVNDNAP + + E
Sbjct: 304 VIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDA 363
Query: 256 ANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKS 315
GT++T ++ D D GVNG+V S + + FK S + L LD E +
Sbjct: 364 QPGTVITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYS---LVLDSALDRESVSA 420
Query: 316 YEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVS 375
YE+ V A D GSP + V V+V DVNDNAP A + ++E+ P I ++
Sbjct: 421 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAG 480
Query: 376 DRDSGANGQVTCSLMP-HVPFKLVSTFKNYYS----LVLDSALDRESLSVYELVVTARDG 430
D D+ N V+ SL+ V + +S++ + ++ + LD E L + + V+ARD
Sbjct: 481 DADAQKNALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDA 540
Query: 431 GSPSLWATARVSVEVADVNDNAPAFAQPE-------YTVFVKENNPPGCHIFTVSARDAD 483
G P L + + V V D NDNAPA P V + G + V A DAD
Sbjct: 541 GVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDAD 600
Query: 484 AQENALVSYSL 494
+ NA +SY L
Sbjct: 601 SGYNAWLSYEL 611
>gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo
sapiens]
Length = 803
Score = 780 bits (2014), Expect = 0.0
Identities = 392/534 (73%), Positives = 452/534 (84%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
MVF+ LG + LLL LLLLAAW+VGSGQLHYS+PEEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFR+ASK DLLEVNLQNGILFVNSRIDREELC SAECSIHLE+I DRPLQVFHV+
Sbjct: 61 PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+V+DINDNPP+F EQ + I ESRL +S FP+EGA+DAD+G+N++LTY LS S+YF L
Sbjct: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DV+ + + +K + L L+K LDREE P +L LTATDGGKPEL GTV+LL+TVLDVNDNAP
Sbjct: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
F+Q+ Y V + E NGT V LNASD DEG NG + +SF+S ++ + + F +D ++G
Sbjct: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EI + LD+E+ Y+I + A DKG PPM+ HC VLV++LD NDN PE+A+TSL LP+R
Sbjct: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDA TVIALI+V+D DSGANGQV CSL PHVPFKLVSTFKNYYSLVLDSALDRES+S
Sbjct: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATA +SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGERALS+Y+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
Score = 150 bits (379), Expect = 4e-36
Identities = 118/392 (30%), Positives = 183/392 (46%), Gaps = 28/392 (7%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPS----- 175
V V D+NDN P F E + I E+ + A+D D GAN ++Y+ +
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMV 289
Query: 176 -DYFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLD 234
D+FS+D + + +R LD E+ +L+ ATD G P + G +L+ +LD
Sbjct: 290 IDHFSIDRNTGE-------IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILD 342
Query: 235 VNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFK 294
NDN P + + E GT++ ++ +D D G NG+V S + + FK
Sbjct: 343 KNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFK 402
Query: 295 VDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTS 354
S + L LD E +YE+ V A D GSP + + V+V D+NDNAP A
Sbjct: 403 NYYS---LVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE 459
Query: 355 LYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPH-VPFKLVSTFKNYYS----LVL 409
+ ++E+ P I ++ D D+ N V+ SL+ V + +S++ + ++ +
Sbjct: 460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYA 519
Query: 410 DSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPE-------YTV 462
LD E L + + V+ARD G P L + + V V D NDNAPA P +
Sbjct: 520 LQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSE 579
Query: 463 FVKENNPPGCHIFTVSARDADAQENALVSYSL 494
V + G + V A DAD+ NA +SY L
Sbjct: 580 LVPRSLGAGQVVAKVRAVDADSGYNAWLSYEL 611
Score = 136 bits (343), Expect = 6e-32
Identities = 110/349 (31%), Positives = 157/349 (44%), Gaps = 33/349 (9%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
V V++ D NDN P + + E + + D D GAN + +L+P F
Sbjct: 336 VLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPF 395
Query: 179 SLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDN 238
L + S L L LDRE L++TA DGG P L T L + V D+NDN
Sbjct: 396 KLVSTFKNYYS----LVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDN 451
Query: 239 APLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK-----F 293
AP F Q Y V + E G + T++A DAD N V +S + R + E+
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL---VERRVGERALSSYI 508
Query: 294 KVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL--- 350
V + SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L
Sbjct: 509 SVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAP 568
Query: 351 -------AVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMP-----HVPFKLV 398
AV+ L + V+A + D DSG N ++ L P PF+ V
Sbjct: 569 RVGGTGGAVSEL---VPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFR-V 624
Query: 399 STFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVAD 447
+ S LD + L+V +D G P+L ATA V V + +
Sbjct: 625 GLYTGEISTT--RVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVE 671
>gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens]
Length = 950
Score = 780 bits (2014), Expect = 0.0
Identities = 392/534 (73%), Positives = 452/534 (84%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
MVF+ LG + LLL LLLLAAW+VGSGQLHYS+PEEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFR+ASK DLLEVNLQNGILFVNSRIDREELC SAECSIHLE+I DRPLQVFHV+
Sbjct: 61 PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+V+DINDNPP+F EQ + I ESRL +S FP+EGA+DAD+G+N++LTY LS S+YF L
Sbjct: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
DV+ + + +K + L L+K LDREE P +L LTATDGGKPEL GTV+LL+TVLDVNDNAP
Sbjct: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
F+Q+ Y V + E NGT V LNASD DEG NG + +SF+S ++ + + F +D ++G
Sbjct: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EI + LD+E+ Y+I + A DKG PPM+ HC VLV++LD NDN PE+A+TSL LP+R
Sbjct: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDA TVIALI+V+D DSGANGQV CSL PHVPFKLVSTFKNYYSLVLDSALDRES+S
Sbjct: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATA +SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQENALVSYSLVERRVGERALS+Y+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
Score = 319 bits (817), Expect = 6e-87
Identities = 152/153 (99%), Positives = 153/153 (100%)
Query: 534 QPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 593
+PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP
Sbjct: 798 KPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 857
Query: 594 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 653
VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG
Sbjct: 858 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 917
Query: 654 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 918 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 950
Score = 150 bits (379), Expect = 4e-36
Identities = 118/392 (30%), Positives = 183/392 (46%), Gaps = 28/392 (7%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPS----- 175
V V D+NDN P F E + I E+ + A+D D GAN ++Y+ +
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMV 289
Query: 176 -DYFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLD 234
D+FS+D + + +R LD E+ +L+ ATD G P + G +L+ +LD
Sbjct: 290 IDHFSIDRNTGE-------IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILD 342
Query: 235 VNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFK 294
NDN P + + E GT++ ++ +D D G NG+V S + + FK
Sbjct: 343 KNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFK 402
Query: 295 VDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTS 354
S + L LD E +YE+ V A D GSP + + V+V D+NDNAP A
Sbjct: 403 NYYS---LVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE 459
Query: 355 LYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPH-VPFKLVSTFKNYYS----LVL 409
+ ++E+ P I ++ D D+ N V+ SL+ V + +S++ + ++ +
Sbjct: 460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYA 519
Query: 410 DSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPE-------YTV 462
LD E L + + V+ARD G P L + + V V D NDNAPA P +
Sbjct: 520 LQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSE 579
Query: 463 FVKENNPPGCHIFTVSARDADAQENALVSYSL 494
V + G + V A DAD+ NA +SY L
Sbjct: 580 LVPRSLGAGQVVAKVRAVDADSGYNAWLSYEL 611
Score = 136 bits (343), Expect = 6e-32
Identities = 110/349 (31%), Positives = 157/349 (44%), Gaps = 33/349 (9%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
V V++ D NDN P + + E + + D D GAN + +L+P F
Sbjct: 336 VLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPF 395
Query: 179 SLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDN 238
L + S L L LDRE L++TA DGG P L T L + V D+NDN
Sbjct: 396 KLVSTFKNYYS----LVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDN 451
Query: 239 APLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK-----F 293
AP F Q Y V + E G + T++A DAD N V +S + R + E+
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL---VERRVGERALSSYI 508
Query: 294 KVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL--- 350
V + SG++ + LD+EE + + QV A D G PP+ ++ + V VLD NDNAP L
Sbjct: 509 SVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAP 568
Query: 351 -------AVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMP-----HVPFKLV 398
AV+ L + V+A + D DSG N ++ L P PF+ V
Sbjct: 569 RVGGTGGAVSEL---VPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFR-V 624
Query: 399 STFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVAD 447
+ S LD + L+V +D G P+L ATA V V + +
Sbjct: 625 GLYTGEISTT--RVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVE 671
>gi|14165381 protocadherin alpha 10 isoform 2 precursor [Homo
sapiens]
Length = 844
Score = 775 bits (2001), Expect = 0.0
Identities = 395/531 (74%), Positives = 447/531 (84%)
Query: 4 SRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRL 63
SR LG + LLL LLLLAAWEVGSGQLHYS+ EEA+HGTFVGR+AQDLGLELAELV RL
Sbjct: 3 SRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRL 62
Query: 64 FRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKV 123
FRVASK H DLLEVNLQNGILFVNSRIDREELC S ECSIHLE+I DRPLQVFHV+V+V
Sbjct: 63 FRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEV 122
Query: 124 KDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVE 183
KDINDNPP F EQ + IPESRLL+SRFP+EGA+DAD+G NALLTY LSP++YF LD+
Sbjct: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDII 182
Query: 184 ASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFD 243
+ K L LRK LDREE P+L LLLTATDGGKPE G+V LLI VLD NDNAP+FD
Sbjct: 183 NKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFD 242
Query: 244 QAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIR 303
+ VY V + E N TLV LNASD+DEG+N E+++SF S + I+ KF ++ +GEI+
Sbjct: 243 RPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIK 302
Query: 304 LIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDA 363
+ D +D+E++ +YEI V DKG+PPM HC VLV++LD NDN+PE+ VTSL LP++EDA
Sbjct: 303 VNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDA 362
Query: 364 PLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYEL 423
+ TVIALI+VSD DSGANGQVTCSL PHVPFKLVST+KNYYSLVLDSALDRE +S YEL
Sbjct: 363 QVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYEL 422
Query: 424 VVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDAD 483
VVTARDGGSP LWATA VSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DAD
Sbjct: 423 VVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDAD 482
Query: 484 AQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
AQENALVSYSLVERR+GER+LS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 483 AQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
Score = 144 bits (364), Expect = 2e-34
Identities = 125/391 (31%), Positives = 177/391 (45%), Gaps = 34/391 (8%)
Query: 77 VNLQNGILFVNSRIDREELCQWSAECSIHLELI-ADRPLQVFHVEVKVK--DINDNPPVF 133
+N + G + VN ID E+ S IH+++ P V H V V+ D NDN P
Sbjct: 294 INERTGEIKVNDAIDFED----SNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEV 349
Query: 134 RGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLW 193
+ + E + + + +D D GAN +T +L+P F L + S
Sbjct: 350 IVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYS---- 405
Query: 194 LELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLE 253
L L LDRE L++TA DGG P L T + + V DVNDNAP F Q+ Y V + E
Sbjct: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKE 465
Query: 254 TTANGTLVTTLNASDADEGVNGEVVFSFDSGI--SRDIQEKFKVDSSSGEIRLIDKLDYE 311
G + T++A DAD N V +S R + V + SG++ + LD+E
Sbjct: 466 NNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHE 525
Query: 312 ETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL----------AVTSLYLPIRE 361
E + + QV A D G PP+ ++ + V VLD NDNAP L AV+ L L
Sbjct: 526 ELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGAVSELVL---R 582
Query: 362 DAPLSTVIALITVSDRDSGANGQVTCSLM-----PHVPFKLVSTFKNYYSLVLDSALDRE 416
V+A + D DSG N ++ L +PF+ V + S ALD
Sbjct: 583 SVVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIPFR-VGLYTGEISTT--RALDET 639
Query: 417 SLSVYELVVTARDGGSPSLWATARVSVEVAD 447
L+V +D G PSL ATA V V + +
Sbjct: 640 DSPRQRLLVLVKDHGEPSLTATATVLVSLVE 670
Score = 142 bits (359), Expect = 8e-34
Identities = 123/432 (28%), Positives = 188/432 (43%), Gaps = 34/432 (7%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
+ V D NDN P+F + + E+++ + A+D+D G N + Y+ S
Sbjct: 229 ILVLDANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSL----- 283
Query: 181 DVEASDELSKSLWLELRK-------YLDREETPELHLLLTATDGGKPELQGTVELLITVL 233
+ + W+ R +D E++ + + TD G P + G +L+ +L
Sbjct: 284 ---VPPTIRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELL 340
Query: 234 DVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKF 293
D NDN+P + + E GT++ ++ SD D G NG+V S + + +
Sbjct: 341 DENDNSPEVIVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTY 400
Query: 294 KVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVT 353
K S + L LD E +YE+ V A D GSPP+ V V+V DVNDNAP A +
Sbjct: 401 KNYYS---LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQS 457
Query: 354 SLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSA- 412
+ ++E+ P I ++ D D+ N V+ SL+ + + +Y S+ +S
Sbjct: 458 EYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGE--RSLSSYVSVHAESGK 515
Query: 413 ------LDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAF-------AQPE 459
LD E L + + V+ARDGG P L + + V V D NDNAPA A
Sbjct: 516 VYALQPLDHEELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGA 575
Query: 460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYA 519
+ V + G + V A DAD+ NA +SY L VG R E A
Sbjct: 576 VSELVLRSVVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIPFRVGLYTGEISTTRA 635
Query: 520 LQPLDHEELELL 531
L D LL
Sbjct: 636 LDETDSPRQRLL 647
>gi|9256574 protocadherin alpha 10 isoform 1 precursor [Homo
sapiens]
Length = 948
Score = 775 bits (2001), Expect = 0.0
Identities = 395/531 (74%), Positives = 447/531 (84%)
Query: 4 SRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRL 63
SR LG + LLL LLLLAAWEVGSGQLHYS+ EEA+HGTFVGR+AQDLGLELAELV RL
Sbjct: 3 SRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRL 62
Query: 64 FRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKV 123
FRVASK H DLLEVNLQNGILFVNSRIDREELC S ECSIHLE+I DRPLQVFHV+V+V
Sbjct: 63 FRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEV 122
Query: 124 KDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVE 183
KDINDNPP F EQ + IPESRLL+SRFP+EGA+DAD+G NALLTY LSP++YF LD+
Sbjct: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDII 182
Query: 184 ASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFD 243
+ K L LRK LDREE P+L LLLTATDGGKPE G+V LLI VLD NDNAP+FD
Sbjct: 183 NKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFD 242
Query: 244 QAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIR 303
+ VY V + E N TLV LNASD+DEG+N E+++SF S + I+ KF ++ +GEI+
Sbjct: 243 RPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIK 302
Query: 304 LIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDA 363
+ D +D+E++ +YEI V DKG+PPM HC VLV++LD NDN+PE+ VTSL LP++EDA
Sbjct: 303 VNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDA 362
Query: 364 PLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYEL 423
+ TVIALI+VSD DSGANGQVTCSL PHVPFKLVST+KNYYSLVLDSALDRE +S YEL
Sbjct: 363 QVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYEL 422
Query: 424 VVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDAD 483
VVTARDGGSP LWATA VSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DAD
Sbjct: 423 VVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDAD 482
Query: 484 AQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
AQENALVSYSLVERR+GER+LS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 483 AQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
Score = 422 bits (1086), Expect = e-118
Identities = 296/672 (44%), Positives = 364/672 (54%), Gaps = 79/672 (11%)
Query: 77 VNLQNGILFVNSRIDREELCQWSAECSIHLELI-ADRPLQVFHVEVKVK--DINDNPPVF 133
+N + G + VN ID E+ S IH+++ P V H V V+ D NDN P
Sbjct: 294 INERTGEIKVNDAIDFED----SNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEV 349
Query: 134 RGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLW 193
+ + E + + + +D D GAN +T +L+P F L + S
Sbjct: 350 IVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYS---- 405
Query: 194 LELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLE 253
L L LDRE L++TA DGG P L T + + V DVNDNAP F Q+ Y V + E
Sbjct: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKE 465
Query: 254 TTANGTLVTTLNASDADEGVNGEVVFSFDSGI--SRDIQEKFKVDSSSGEIRLIDKLDYE 311
G + T++A DAD N V +S R + V + SG++ + LD+E
Sbjct: 466 NNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHE 525
Query: 312 ETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL----------AVTSLYLPIRE 361
E + + QV A D G PP+ ++ + V VLD NDNAP L AV+ L L
Sbjct: 526 ELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGAVSELVL---R 582
Query: 362 DAPLSTVIALITVSDRDSGANGQVTCSLMP-----HVPFKL------VSTFK-------- 402
V+A + D DSG N ++ L +PF++ +ST +
Sbjct: 583 SVVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIPFRVGLYTGEISTTRALDETDSP 642
Query: 403 NYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTV 462
LVL SL+ V+ + GS + A++R SV VA P A + V
Sbjct: 643 RQRLLVLVKDHGEPSLTATATVLVSLVEGSQAPKASSRASVGVA------PEVALVDVNV 696
Query: 463 F-------VKENNPPGCHIFTVSARDADAQENAL--VSYSLV-ERRVGERALSNYVSVHA 512
+ V ++T A E A V +LV VG + S
Sbjct: 697 YLIIAICAVSSLLVLTLLLYTALRCSAAPTEGACGPVKPTLVCSSAVGSWSYSQQRRQRV 756
Query: 513 ESGK------VYALQP---------LDHEELEL---LQFQPRQPNPDWRYSASLRAGMHS 554
SG+ + A P +D E+ + +PRQPNPDWRYSASLRAGMHS
Sbjct: 757 CSGEGLPKADLMAFSPSLPPCPMVDVDGEDQSIGGDHSRKPRQPNPDWRYSASLRAGMHS 816
Query: 555 SVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 614
SVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ
Sbjct: 817 SVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 876
Query: 615 SGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKK 674
SGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKK
Sbjct: 877 SGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKK 936
Query: 675 EKGNSTTDNSDQ 686
EKGNSTTDNSDQ
Sbjct: 937 EKGNSTTDNSDQ 948
Score = 142 bits (359), Expect = 8e-34
Identities = 123/432 (28%), Positives = 188/432 (43%), Gaps = 34/432 (7%)
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
+ V D NDN P+F + + E+++ + A+D+D G N + Y+ S
Sbjct: 229 ILVLDANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSL----- 283
Query: 181 DVEASDELSKSLWLELRK-------YLDREETPELHLLLTATDGGKPELQGTVELLITVL 233
+ + W+ R +D E++ + + TD G P + G +L+ +L
Sbjct: 284 ---VPPTIRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELL 340
Query: 234 DVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKF 293
D NDN+P + + E GT++ ++ SD D G NG+V S + + +
Sbjct: 341 DENDNSPEVIVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTY 400
Query: 294 KVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVT 353
K S + L LD E +YE+ V A D GSPP+ V V+V DVNDNAP A +
Sbjct: 401 KNYYS---LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQS 457
Query: 354 SLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSA- 412
+ ++E+ P I ++ D D+ N V+ SL+ + + +Y S+ +S
Sbjct: 458 EYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGE--RSLSSYVSVHAESGK 515
Query: 413 ------LDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAF-------AQPE 459
LD E L + + V+ARDGG P L + + V V D NDNAPA A
Sbjct: 516 VYALQPLDHEELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGA 575
Query: 460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYA 519
+ V + G + V A DAD+ NA +SY L VG R E A
Sbjct: 576 VSELVLRSVVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIPFRVGLYTGEISTTRA 635
Query: 520 LQPLDHEELELL 531
L D LL
Sbjct: 636 LDETDSPRQRLL 647
>gi|14165392 protocadherin alpha 12 isoform 2 precursor [Homo
sapiens]
Length = 792
Score = 758 bits (1958), Expect = 0.0
Identities = 392/534 (73%), Positives = 443/534 (82%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
MV G G++ LLL LLLLAAWEVGSGQLHYS+ EEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MVIIGPRGPGSQRLLLSLLLLAAWEVGSGQLHYSVYEEAKHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK H DLLEVNLQNGILFVNSRIDRE+LC SAECSIHLE+I DRPLQVFHV+
Sbjct: 61 PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREKLCGRSAECSIHLEVIVDRPLQVFHVD 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+VKDINDNPPVFR REQ + + ES L+S FP+EGA+DADIG N+LLTY LS ++ F L
Sbjct: 121 VEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFEL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
++ + S L LRK LDRE+TP+L+LLL DGGKPEL G+V++ ITVLDVNDN P
Sbjct: 181 KIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
FD+ Y+V L E N T V LNASD DEG+NGE+ + + + F ++ +G
Sbjct: 241 AFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EIR+ +LD+EE +YEIQV A+DKG P M+ H VLV+VLDVNDN PE+ VTSL LP++
Sbjct: 301 EIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQ 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDA + TVIALI+VSDRDSGANGQV CSL PHVPFKLVST+KNYYSLVLDSALDRES+S
Sbjct: 361 EDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQ+NALVSYSLVERRVGE ALS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 149 bits (376), Expect = 8e-36
Identities = 122/402 (30%), Positives = 181/402 (45%), Gaps = 32/402 (7%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTL------ 172
+++ V D+NDN P F + + E+ ++R A+D D G N ++Y +
Sbjct: 228 IQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPV 287
Query: 173 SPSDYFSLDVEASDELSKSLWLELRKY--LDREETPELHLLLTATDGGKPELQGTVELLI 230
S FS++ + E+R Y LD EE + + A D G P + G +L+
Sbjct: 288 SEKCMFSINPDTG---------EIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLV 338
Query: 231 TVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQ 290
VLDVNDN P + + E GT++ ++ SD D G NG+V+ S + +
Sbjct: 339 EVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLV 398
Query: 291 EKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL 350
+K S + L LD E +YE+ V A D GSP + +V V+V DVNDNAP
Sbjct: 399 STYKNYYS---LVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAF 455
Query: 351 AVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMP-----HVPFKLVSTFKNYY 405
A + ++E+ P I ++ D D+ N V+ SL+ H VS
Sbjct: 456 AQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESG 515
Query: 406 SLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAF-------AQP 458
+ LD E L + + V+ARD G P L + + V V D NDNAPA A
Sbjct: 516 KVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGG 575
Query: 459 EYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVG 500
+ V + G + V A DAD+ NA +SY L VG
Sbjct: 576 AVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVG 617
Score = 145 bits (366), Expect = 1e-34
Identities = 133/443 (30%), Positives = 198/443 (44%), Gaps = 48/443 (10%)
Query: 30 QLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDLLEVNLQNGILFVNSR 89
QL+ S P+E +G E++ + + V+ K + +N G + +
Sbjct: 263 QLNASDPDEGLNG------------EISYGIKMILPVSEKC---MFSINPDTGEIRIYGE 307
Query: 90 IDREELCQWSAECSIHLELIADRPLQVFH--VEVKVKDINDNPPVFRGREQIIFIPESRL 147
+D EE + + + + I P H V V+V D+NDN P + + E
Sbjct: 308 LDFEENNAYEIQVNAIDKGI---PSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQ 364
Query: 148 LNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLWLELRKYLDREETPE 207
+ + + +D D GAN + +L+P F L + S L L LDRE
Sbjct: 365 VGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYS----LVLDSALDRESVSA 420
Query: 208 LHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNAS 267
L++TA DGG P L T + + V DVNDNAP F Q Y V + E G + T++A
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW 480
Query: 268 DADEGVNGEVVFSFDSGISRDIQEK-----FKVDSSSGEIRLIDKLDYEETKSYEIQVKA 322
DAD N V +S + R + E V + SG++ + LD+EE + + QV A
Sbjct: 481 DADAQKNALVSYSL---VERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSA 537
Query: 323 VDKGSPPMSNHCKVLVKVLDVNDNAPELAVT---SLYLPIREDAPLST----VIALITVS 375
D G PP+ ++ + V VLD NDNAP L T S + E P S V+A +
Sbjct: 538 RDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAV 597
Query: 376 DRDSGANGQVTCSLMP-----HVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDG 430
D DSG N ++ L P H+PF V + S LD + L+V +D
Sbjct: 598 DADSGYNAWLSYELQPAAVGAHIPFH-VGLYTGEISTT--RILDEADAPRHRLLVLVKDH 654
Query: 431 GSPSLWATARVSVEVADVNDNAP 453
G P+L +TA V V + + N AP
Sbjct: 655 GEPALTSTATVLVSLVE-NGQAP 676
>gi|9256578 protocadherin alpha 12 isoform 1 precursor [Homo
sapiens]
Length = 941
Score = 758 bits (1958), Expect = 0.0
Identities = 392/534 (73%), Positives = 443/534 (82%)
Query: 1 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60
MV G G++ LLL LLLLAAWEVGSGQLHYS+ EEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1 MVIIGPRGPGSQRLLLSLLLLAAWEVGSGQLHYSVYEEAKHGTFVGRIAQDLGLELAELV 60
Query: 61 PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120
PRLFRVASK H DLLEVNLQNGILFVNSRIDRE+LC SAECSIHLE+I DRPLQVFHV+
Sbjct: 61 PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREKLCGRSAECSIHLEVIVDRPLQVFHVD 120
Query: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180
V+VKDINDNPPVFR REQ + + ES L+S FP+EGA+DADIG N+LLTY LS ++ F L
Sbjct: 121 VEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFEL 180
Query: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240
++ + S L LRK LDRE+TP+L+LLL DGGKPEL G+V++ ITVLDVNDN P
Sbjct: 181 KIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGP 240
Query: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300
FD+ Y+V L E N T V LNASD DEG+NGE+ + + + F ++ +G
Sbjct: 241 AFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTG 300
Query: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360
EIR+ +LD+EE +YEIQV A+DKG P M+ H VLV+VLDVNDN PE+ VTSL LP++
Sbjct: 301 EIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQ 360
Query: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420
EDA + TVIALI+VSDRDSGANGQV CSL PHVPFKLVST+KNYYSLVLDSALDRES+S
Sbjct: 361 EDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSA 420
Query: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW 480
Query: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534
DADAQ+NALVSYSLVERRVGE ALS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534
Score = 434 bits (1115), Expect = e-121
Identities = 300/713 (42%), Positives = 379/713 (53%), Gaps = 90/713 (12%)
Query: 30 QLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDLLEVNLQNGILFVNSR 89
QL+ S P+E +G E++ + + V+ K + +N G + +
Sbjct: 263 QLNASDPDEGLNG------------EISYGIKMILPVSEKC---MFSINPDTGEIRIYGE 307
Query: 90 IDREELCQWSAECSIHLELIADRPLQVFH--VEVKVKDINDNPPVFRGREQIIFIPESRL 147
+D EE + + + + I P H V V+V D+NDN P + + E
Sbjct: 308 LDFEENNAYEIQVNAIDKGI---PSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQ 364
Query: 148 LNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLWLELRKYLDREETPE 207
+ + + +D D GAN + +L+P F L + S L L LDRE
Sbjct: 365 VGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYS----LVLDSALDRESVSA 420
Query: 208 LHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNAS 267
L++TA DGG P L T + + V DVNDNAP F Q Y V + E G + T++A
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW 480
Query: 268 DADEGVNGEVVFSFDSGISRDIQEK-----FKVDSSSGEIRLIDKLDYEETKSYEIQVKA 322
DAD N V +S + R + E V + SG++ + LD+EE + + QV A
Sbjct: 481 DADAQKNALVSYSL---VERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSA 537
Query: 323 VDKGSPPMSNHCKVLVKVLDVNDNAPELAVT---SLYLPIREDAPLST----VIALITVS 375
D G PP+ ++ + V VLD NDNAP L T S + E P S V+A +
Sbjct: 538 RDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAV 597
Query: 376 DRDSGANGQVTCSLMP-----HVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDG 430
D DSG N ++ L P H+PF V + S LD + L+V +D
Sbjct: 598 DADSGYNAWLSYELQPAAVGAHIPFH-VGLYTGEISTT--RILDEADAPRHRLLVLVKDH 654
Query: 431 GSPSLWATARVSVEV------------ADVNDNAPAFAQPEYTVFV-------------- 464
G P+L +TA V V + A V P A + V++
Sbjct: 655 GEPALTSTATVLVSLVENGQAPKTSSRASVGAVDPEAALVDINVYLIIAICAVSSLLVLT 714
Query: 465 -------KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAE-SGK 516
+ + PP TVS R A + + S ++ ++ S +
Sbjct: 715 LLLYTALRCSAPP-----TVS-RCAPGKPTLVCSSAVGSWSYSQQRRQRVCSAESPPKTD 768
Query: 517 VYALQP---LDHEELELLQFQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQ 573
+ A P L E+ +PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQ
Sbjct: 769 LMAFSPSLQLSREDCLNPPSEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQ 828
Query: 574 QWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAII 633
QWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAII
Sbjct: 829 QWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAII 888
Query: 634 SIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
SIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 889 SIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 941
Score = 149 bits (376), Expect = 8e-36
Identities = 122/402 (30%), Positives = 181/402 (45%), Gaps = 32/402 (7%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTL------ 172
+++ V D+NDN P F + + E+ ++R A+D D G N ++Y +
Sbjct: 228 IQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPV 287
Query: 173 SPSDYFSLDVEASDELSKSLWLELRKY--LDREETPELHLLLTATDGGKPELQGTVELLI 230
S FS++ + E+R Y LD EE + + A D G P + G +L+
Sbjct: 288 SEKCMFSINPDTG---------EIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLV 338
Query: 231 TVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQ 290
VLDVNDN P + + E GT++ ++ SD D G NG+V+ S + +
Sbjct: 339 EVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLV 398
Query: 291 EKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL 350
+K S + L LD E +YE+ V A D GSP + +V V+V DVNDNAP
Sbjct: 399 STYKNYYS---LVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAF 455
Query: 351 AVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMP-----HVPFKLVSTFKNYY 405
A + ++E+ P I ++ D D+ N V+ SL+ H VS
Sbjct: 456 AQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESG 515
Query: 406 SLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAF-------AQP 458
+ LD E L + + V+ARD G P L + + V V D NDNAPA A
Sbjct: 516 KVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGG 575
Query: 459 EYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVG 500
+ V + G + V A DAD+ NA +SY L VG
Sbjct: 576 AVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVG 617
>gi|14277677 protocadherin gamma subfamily C, 3 isoform 2 precursor
[Homo sapiens]
Length = 863
Score = 468 bits (1203), Expect = e-131
Identities = 238/510 (46%), Positives = 339/510 (66%)
Query: 18 LLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDLLEV 77
LLLL A S +HY IPEE + G VG V +LGL+L L R FRV S R EV
Sbjct: 20 LLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEV 79
Query: 78 NLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKVKDINDNPPVFRGRE 137
N + G +FVN R+DREELC C++ LEL+ + PL++F VEV ++DINDN P F +E
Sbjct: 80 NRETGEMFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQE 139
Query: 138 QIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLWLELR 197
+ I E+ +RFP+E A D D+G+N+L TY LS ++YF+L V+ ++ +K L L
Sbjct: 140 MKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELSRNEYFALRVQTREDSTKYAELVLE 199
Query: 198 KYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTAN 257
+ LDRE P L L+LTA DGG P L ++ + I VLD NDNAP+F+Q++YR +LE +
Sbjct: 200 RALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPS 259
Query: 258 GTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKSYE 317
GT V + A+D DEG NGE+++SF S +++ F +D +G + + +LD+E+TK +E
Sbjct: 260 GTRVVQVLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHE 319
Query: 318 IQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVSDR 377
I ++A DKG+ P HCKVLV+V+DVNDNAPE+ VTS+Y P+ EDAPL TVIAL++V+D
Sbjct: 320 IYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVTSVYSPVPEDAPLGTVIALLSVTDL 379
Query: 378 DSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWA 437
D+G NG VTC + P +PF L S+ KNY++L + LDRE++ Y L +TARD G+PSL A
Sbjct: 380 DAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSA 439
Query: 438 TARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVER 497
V V+V+D+NDN P +Q Y V+++ENN PG I +S D DA +NA +S+ L+E+
Sbjct: 440 LTIVRVQVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQ 499
Query: 498 RVGERALSNYVSVHAESGKVYALQPLDHEE 527
+ Y +++ ++G V +L PLD+E+
Sbjct: 500 GAETGLVGRYFTINRDNGIVSSLVPLDYED 529
Score = 125 bits (314), Expect = 1e-28
Identities = 120/435 (27%), Positives = 189/435 (43%), Gaps = 31/435 (7%)
Query: 37 EEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTH-----RDLLEVNLQNGILFVNSRID 91
E+A GT RV Q L +L E + +H R L ++L G+L + R+D
Sbjct: 255 EDAPSGT---RVVQVLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLD 311
Query: 92 REELCQWSAECSIHLELIADRPLQVF-HVEVKVKDINDNPPVFRGREQIIFIPESRLLNS 150
E+ E I + P V V+V D+NDN P +PE L +
Sbjct: 312 FEDTKLH--EIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVTSVYSPVPEDAPLGT 369
Query: 151 RFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLWLELRKYLDREETPELHL 210
+ D D G N L+T + P FSL + L L+ LDRE PE +L
Sbjct: 370 VIALLSVTDLDAGENGLVTCEVPPGLPFSL----TSSLKNYFTLKTSADLDRETVPEYNL 425
Query: 211 LLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDAD 270
+TA D G P L + + V D+NDN P Q+ Y V++ E G + L+ D D
Sbjct: 426 SITARDAGTPSLSALTIVRVQVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPD 485
Query: 271 EGVNGEV-VFSFDSGISRDIQEK-FKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSP 328
N + F + G + + F ++ +G + + LDYE+ + +E+ D G+P
Sbjct: 486 APQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFELTAHISDGGTP 545
Query: 329 PMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLST----VIALITVSDRDSGANGQ 384
++ + V + V D NDNAP++ E P T +++ + D D+G N
Sbjct: 546 VLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAW 605
Query: 385 VTCSLM--PHVPFKLVSTFKNYYSL---VLDSALDRESLSVYELVVTARDGGSPSLWATA 439
++ SL+ P+ + S V D+ R++L+ V +D G PSL TA
Sbjct: 606 LSYSLLGSPNQSLFAIGLHTGQISTARPVQDTDSPRQTLT-----VLIKDNGEPSLSTTA 660
Query: 440 RVSVEVADVNDNAPA 454
++V V + + A A
Sbjct: 661 TLTVSVTEDSPEARA 675
Score = 122 bits (305), Expect = 1e-27
Identities = 112/395 (28%), Positives = 169/395 (42%), Gaps = 31/395 (7%)
Query: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSD-- 176
+ +KV D NDN PVF + E +R A D D G N + Y+ +
Sbjct: 230 IHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSFGSHNRA 289
Query: 177 ----YFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITV 232
F+LD+ L ++ LD E+T + + A D G ++L+ V
Sbjct: 290 GVRQLFALDLVTG-------MLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEV 342
Query: 233 LDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEK 292
+DVNDNAP + E GT++ L+ +D D G NG V G+ +
Sbjct: 343 VDVNDNAPEITVTSVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSS 402
Query: 293 FKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAV 352
K + ++ LD E Y + + A D G+P +S V V+V D+NDN P+ +
Sbjct: 403 LK---NYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQSSQ 459
Query: 353 TSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPH-VPFKLVSTFKNYYSLVLDS 411
+S + I E+ I ++V D D+ N +++ L+ LV Y+++ D+
Sbjct: 460 SSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVG---RYFTINRDN 516
Query: 412 A-------LDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFV 464
LD E +EL DGG+P L V++ V D NDNAP P
Sbjct: 517 GIVSSLVPLDYEDRREFELTAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSS 576
Query: 465 KENNPPGCH----IFTVSARDADAQENALVSYSLV 495
E P G + V DADA NA +SYSL+
Sbjct: 577 VEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLL 611
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.133 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,038,428
Number of Sequences: 37866
Number of extensions: 1411809
Number of successful extensions: 11522
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 232
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 5601
Number of HSP's gapped (non-prelim): 1517
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.