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Search of human proteins with 96974985
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|96974985 coiled-coil and C2 domain containing 1A [Homo
sapiens]
(951 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|96974985 coiled-coil and C2 domain containing 1A [Homo sapiens] 1890 0.0
gi|61742814 coiled-coil and C2 domain containing 1B [Homo sapiens] 709 0.0
gi|163965366 nascent polypeptide-associated complex alpha subuni... 62 3e-09
gi|150170670 piccolo isoform 2 [Homo sapiens] 59 3e-08
gi|150378539 piccolo isoform 1 [Homo sapiens] 59 3e-08
gi|60460889 Myb protein P42POP [Homo sapiens] 57 6e-08
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 57 8e-08
gi|112421108 capicua homolog [Homo sapiens] 55 2e-07
gi|149158690 HLA-B associated transcript-2 [Homo sapiens] 55 3e-07
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens] 54 5e-07
gi|153792074 proline rich 12 [Homo sapiens] 54 7e-07
gi|148277037 AP2 associated kinase 1 [Homo sapiens] 54 9e-07
gi|150417989 cyclin K isoform 1 [Homo sapiens] 54 9e-07
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 54 9e-07
gi|55749531 splicing factor 3B subunit 2 [Homo sapiens] 53 1e-06
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 53 2e-06
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 53 2e-06
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 53 2e-06
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 53 2e-06
gi|47132519 Ras association and pleckstrin homology domains 1 is... 53 2e-06
gi|116256464 hypothetical protein LOC343990 [Homo sapiens] 53 2e-06
gi|18079216 CASK interacting protein 1 [Homo sapiens] 52 2e-06
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 52 3e-06
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 52 3e-06
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 52 3e-06
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 52 3e-06
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 52 3e-06
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 52 3e-06
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 52 3e-06
gi|146134388 YLP motif containing 1 [Homo sapiens] 52 3e-06
>gi|96974985 coiled-coil and C2 domain containing 1A [Homo sapiens]
Length = 951
Score = 1890 bits (4895), Expect = 0.0
Identities = 951/951 (100%), Positives = 951/951 (100%)
Query: 1 MHKRKGPPGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVGGQPPALE 60
MHKRKGPPGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVGGQPPALE
Sbjct: 1 MHKRKGPPGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVGGQPPALE 60
Query: 61 KLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASET 120
KLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASET
Sbjct: 61 KLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASET 120
Query: 121 PPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASI 180
PPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASI
Sbjct: 121 PPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASI 180
Query: 181 RKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSP 240
RKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSP
Sbjct: 181 RKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSP 240
Query: 241 GLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEAL 300
GLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEAL
Sbjct: 241 GLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEAL 300
Query: 301 SRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQ 360
SRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQ
Sbjct: 301 SRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQ 360
Query: 361 VAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKP 420
VAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKP
Sbjct: 361 VAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKP 420
Query: 421 TQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAK 480
TQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAK
Sbjct: 421 TQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAK 480
Query: 481 APPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNG 540
APPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNG
Sbjct: 481 APPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNG 540
Query: 541 LPVDITKVPPAPVNKDDFALVQRPGPGLSQEAARRYGELTKLIRQQHEMCLNHSNQFTQL 600
LPVDITKVPPAPVNKDDFALVQRPGPGLSQEAARRYGELTKLIRQQHEMCLNHSNQFTQL
Sbjct: 541 LPVDITKVPPAPVNKDDFALVQRPGPGLSQEAARRYGELTKLIRQQHEMCLNHSNQFTQL 600
Query: 601 GNITETTKFEKLAEDCKRSMDILKQAFVRGLPTPTARFEQRTFSVIKIFPDLSSNDMLLF 660
GNITETTKFEKLAEDCKRSMDILKQAFVRGLPTPTARFEQRTFSVIKIFPDLSSNDMLLF
Sbjct: 601 GNITETTKFEKLAEDCKRSMDILKQAFVRGLPTPTARFEQRTFSVIKIFPDLSSNDMLLF 660
Query: 661 IVKGINLPTPPGLSPGDLDVFVRFDFPYPNVEEAQKDKTSVIKNTDSPEFKEQFKLCINR 720
IVKGINLPTPPGLSPGDLDVFVRFDFPYPNVEEAQKDKTSVIKNTDSPEFKEQFKLCINR
Sbjct: 661 IVKGINLPTPPGLSPGDLDVFVRFDFPYPNVEEAQKDKTSVIKNTDSPEFKEQFKLCINR 720
Query: 721 SHRGFRRAIQTKGIKFEVVHKGGLFKTDRVLGTAQLKLDALEIACEVREILEVLDGRRPT 780
SHRGFRRAIQTKGIKFEVVHKGGLFKTDRVLGTAQLKLDALEIACEVREILEVLDGRRPT
Sbjct: 721 SHRGFRRAIQTKGIKFEVVHKGGLFKTDRVLGTAQLKLDALEIACEVREILEVLDGRRPT 780
Query: 781 GGRLEVMVRIREPLTAQQLETTTERWLVIDPVPAAVPTQVAGPKGKAPPVPAPARESGNR 840
GGRLEVMVRIREPLTAQQLETTTERWLVIDPVPAAVPTQVAGPKGKAPPVPAPARESGNR
Sbjct: 781 GGRLEVMVRIREPLTAQQLETTTERWLVIDPVPAAVPTQVAGPKGKAPPVPAPARESGNR 840
Query: 841 SARPLHSLSVLAFDQERLERKILALRQARRPVPPEVAQQYQDIMQRSQWQRAQLEQGGVG 900
SARPLHSLSVLAFDQERLERKILALRQARRPVPPEVAQQYQDIMQRSQWQRAQLEQGGVG
Sbjct: 841 SARPLHSLSVLAFDQERLERKILALRQARRPVPPEVAQQYQDIMQRSQWQRAQLEQGGVG 900
Query: 901 IRREYAAQLERQLQFYTEAARRLGNDGSRDAAKEALYRRNLVESELQRLRR 951
IRREYAAQLERQLQFYTEAARRLGNDGSRDAAKEALYRRNLVESELQRLRR
Sbjct: 901 IRREYAAQLERQLQFYTEAARRLGNDGSRDAAKEALYRRNLVESELQRLRR 951
>gi|61742814 coiled-coil and C2 domain containing 1B [Homo sapiens]
Length = 858
Score = 709 bits (1831), Expect = 0.0
Identities = 408/865 (47%), Positives = 546/865 (63%), Gaps = 74/865 (8%)
Query: 4 RKGPPGPPGRGAAAARQLGLLVDLSPDGLMIPEDGA-NDEELEAEFLALVG-----GQPP 57
RKGP G+G AAA+Q+GL ++ P+ +++ D A +DE+LEAE LAL G G+ P
Sbjct: 8 RKGPQAR-GQGVAAAKQMGLFMEFGPEDMLLGMDEAEDDEDLEAELLALTGEAQTTGKKP 66
Query: 58 ALEKLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLG----- 112
A KG+ PLPM IEK+A+ CMRD +E+EEE + LE D +LL EL EVLG
Sbjct: 67 AP---KGQAPLPMAHIEKLAADCMRDVEEEEEE----EGLEEDAELLTELQEVLGVDEET 119
Query: 113 ---------------EEQKASETPPPVAQPKPEAPHP--------GLETTLQERLALYQT 149
EE +T PPV A P GL L+ER+ Y+
Sbjct: 120 EPLDGDEVADPGGSEEENGLEDTEPPVQTAVLTASAPAAQAGASQGLHALLEERIHNYRE 179
Query: 150 AIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSP 209
A SA++AG++AK RR +RGLKTLE+ LAS+R+G I+E +IPPPVA+GK P
Sbjct: 180 AAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKRPL------- 232
Query: 210 APTQPAPRIASAPEPRV-TLEGPSATAPASS-PGLAKPQMPPGPCSPGPLAQLQSRQRDY 267
AP +PA R P LE + + P +S PG++ P P P A L SRQR+Y
Sbjct: 233 APQEPANRSPETDPPAPPALESDNPSQPETSLPGISA--QPVSDLDPDPRALLSSRQREY 290
Query: 268 KLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPS--- 324
K+AAL AK+ G+ A R+ K F AVLEAL +G+PVDLS +PP P+ L P S
Sbjct: 291 KVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAP 350
Query: 325 ------PPS----QPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRK 374
PP+ QP P+T P +T+L+AL+QR+ +Y+ A QA+S GD+RK
Sbjct: 351 TAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERK 410
Query: 375 ARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGV-LETAM 433
ARMHERI KQYQDAIRAH+AGR V+ AELPVPPGFPPI GLE+T ++ V L A
Sbjct: 411 ARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAE 470
Query: 434 KLAN-QDEGPEDEEDEVPKK--QNSPVAPTAQPKAPPSRTPQSGSA---PTAKAPPKATS 487
KLA+ +D P D++++ P Q P A K P T S P A + ++ S
Sbjct: 471 KLASAEDSAPADKDEDEPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPS 530
Query: 488 TRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITK 547
++QLA LE RK Q +AAL+AK+ D+E AK +LR AK LE + +R+G PVD++K
Sbjct: 531 PSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSK 590
Query: 548 VP-PAPVNKDDFALVQRPGPGLSQEAARRYGELTKLIRQQHEMCLNHSNQFTQLGNITET 606
VP P + DF L+ LSQ+A Y +L K++ +Q E CL S QF GN+ ET
Sbjct: 591 VPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAET 650
Query: 607 TKFEKLAEDCKRSMDILKQAFVRGLPTPTARFEQRTFSVIKIFPDLSSNDMLLFIVKGIN 666
T+FEKLA+D K+ ++IL+ A +GL PT FE +TF ++IF +L+S +M L IV+G+N
Sbjct: 651 TRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMN 710
Query: 667 LPTPPGLSPGDLDVFVRFDFPYPNVEEAQKDKTSVIKNTDSPEFKEQFKLCINRSHRGFR 726
LP PPG++P DLD FVRF+F YPN ++AQK KT+V+KNT+SPEF + FKL INR+HRGF+
Sbjct: 711 LPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFK 770
Query: 727 RAIQTKGIKFEVVHKGGLFKTDRVLGTAQLKLDALEIACEVREILEVLDGRRPTGGRLEV 786
R IQ+KGIKFE+ HKG F++D+++GTA LKL+ LE CE+REI+EVLDGR+PTGG+LEV
Sbjct: 771 RVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEV 830
Query: 787 MVRIREPLTAQQLETTTERWLVIDP 811
VR+REPL+ Q ++ TE WLV++P
Sbjct: 831 KVRLREPLSGQDVQMVTENWLVLEP 855
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 61.6 bits (148), Expect = 3e-09
Identities = 100/399 (25%), Positives = 129/399 (32%), Gaps = 64/399 (16%)
Query: 120 TPPPVAQPK-----PEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLE 174
TPPP P P +P GL T + A + + G
Sbjct: 1142 TPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGG---------------- 1185
Query: 175 NLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSAT 234
L KG A PP KG +TP+ APT PA A+ P P+ L PS
Sbjct: 1186 -LATPSPKGAPTTPAATPPSP---KGGLATPSPKGAPTTPA---ATPPSPKGGLATPSPK 1238
Query: 235 APASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFD 294
++P P GP +P P + AA +G A + A +
Sbjct: 1239 GAPTTPAATPPSPKGGPATPPP------KGAPTPPAATPPSLKGGL--ATPPHKGAPNPA 1290
Query: 295 AVLEALSRGEPVDL--SCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEAL 352
V +G P P PP PP P P PP P AP+ V PP L
Sbjct: 1291 VVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPP-PKGAPTPPAVTPPSPKGTPTL 1349
Query: 353 EQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPI 412
A SKG E A +HK G A+ P P
Sbjct: 1350 ---------PATTPSSKGGPTTPSSKEGPTP--PAATPSHKGGPAMTPPSPKRGPAIPSP 1398
Query: 413 QGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQ 472
+G + T P L A + + + D P V P + KAP + P+
Sbjct: 1399 KG-DPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTP----PAVTPVSLKKAPATSAPK 1453
Query: 473 SGSA-------PT--AKAPPKATSTRAQQQLAFLEGRKK 502
G A PT A PP A +Q+A KK
Sbjct: 1454 GGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKK 1492
Score = 53.5 bits (127), Expect = 9e-07
Identities = 89/387 (22%), Positives = 127/387 (32%), Gaps = 28/387 (7%)
Query: 191 IPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPG 250
+P KG +TP+ PT P A+ P + GP+ T P+ G A P
Sbjct: 1349 LPATTPSSKGGPTTPSSKEGPTPP----AATPSHK---GGPAMTPPSPKRGPAIPSPKGD 1401
Query: 251 PCSPG--PLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDL 308
P SP PL+ ++ +GD T A K A + +G P
Sbjct: 1402 PTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPAT--SAPKGGPATP 1459
Query: 309 SCLPPP--PDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQA 366
S P P PP P PP+ P AT+ S + P P + + A
Sbjct: 1460 SSKGDPTLPAVTPPSPKEPPA-PKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPA 1518
Query: 367 KSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLV 426
+ ++ + A A K +P P P I + T S
Sbjct: 1519 TPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKE 1578
Query: 427 GVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKAT 486
A+ + P +E +P SP +P P PP+ TP S A PK T
Sbjct: 1579 ASSPPAVTPSTYKGAPSPKELLIPPAVTSP-SPKEAP-TPPAVTPPSPEKGPATPAPKGT 1636
Query: 487 STRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDIT 546
T + L + A++ K V A L KG + E
Sbjct: 1637 PTSPPVTPSSL--KDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKE----------V 1684
Query: 547 KVPPAPVNKDDFALVQRPGPGLSQEAA 573
V PAP + R GP + +A
Sbjct: 1685 LVAPAPESTPIITAPTRKGPQTKKSSA 1711
Score = 48.9 bits (115), Expect = 2e-05
Identities = 77/319 (24%), Positives = 100/319 (31%), Gaps = 55/319 (17%)
Query: 192 PPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPG- 250
P P A+ T P T P P + + P P+ EGP+ AP +P L+ P
Sbjct: 865 PTPSAVTPLSPKGVTLPPKET-PTPSVVNLPFPK---EGPATPAPKQAPALSMTSSSPKK 920
Query: 251 ----PCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPV 306
P G A + AA +G + + A + A +G P
Sbjct: 921 ARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKW--APTPPAATPPSPKGGPA 978
Query: 307 DLSC--LPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAA 364
S P PP PP P P+ P +P AP+ V PP AA
Sbjct: 979 TPSPKGAPTPPAATPPSPKGGPATP-SPKGAPTPPAVTPPSPK------------GSPAA 1025
Query: 365 QAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQS 424
KG K A K A LP P G P L+ PT
Sbjct: 1026 TPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGA-PTPP- 1083
Query: 425 LVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAP---------------PSR 469
A + GP P + +P+ P A P +P P+
Sbjct: 1084 -------AATPPSPKGGPA-----TPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAA 1131
Query: 470 TPQSGSAPTAKAPPKATST 488
TP S A PPK T
Sbjct: 1132 TPPSPKGGLATPPPKGAPT 1150
Score = 48.5 bits (114), Expect = 3e-05
Identities = 82/319 (25%), Positives = 101/319 (31%), Gaps = 69/319 (21%)
Query: 182 KGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPG 241
KG A PP KG +TP+ APT PA A+ P P+ PS + P
Sbjct: 937 KGAPTPPAATPPSP---KGGPATPSPKWAPTPPA---ATPPSPKGGPATPSPKGAPTPPA 990
Query: 242 LAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALS 301
P GP +P P A+ + AA + A + A
Sbjct: 991 ATPPSPKGGPATPSPKGAPTP-------PAVTPPSPKGSPAATPFPKGASTPPAATPPSP 1043
Query: 302 RGEPVDLSCLPPPPDQLPPDP----PSPPSQPPTPA-----TAPSTTEVPPPPRTLLEAL 352
+G P P P P P PSP P TP+ T P+ T PP P+
Sbjct: 1044 KGSP----AATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAAT--PPSPKGGPATP 1097
Query: 353 EQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPG---F 409
+ AA KG A HK A P P G
Sbjct: 1098 SPKGAPMPPAATPPSPKGGL---------------ATPPHKGAPTTPAATPPSPKGGLAT 1142
Query: 410 PPIQGLEAT-KPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPS 468
PP +G T T S G L T P + +P P A P +P
Sbjct: 1143 PPPKGAPTTPAATPPSPKGGLAT------------------PPPKGAPTTPAATPPSPKG 1184
Query: 469 --RTPQSGSAPT--AKAPP 483
TP APT A PP
Sbjct: 1185 GLATPSPKGAPTTPAATPP 1203
Score = 47.4 bits (111), Expect = 6e-05
Identities = 87/333 (26%), Positives = 106/333 (31%), Gaps = 55/333 (16%)
Query: 182 KGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIAS------APEPRVTLEGPSATA 235
KG + A PP KG +TP + APT PA S P P+ P+AT
Sbjct: 1100 KGAPMPPAATPPSP---KGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATP 1156
Query: 236 PASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDA 295
P+ GLA P PP P A S + A + + TT AA
Sbjct: 1157 PSPKGGLATP--PPKGAPTTPAATPPSPKGGL---ATPSPKGAPTTPAATP---PSPKGG 1208
Query: 296 VLEALSRGEPVDLSCLPPPPD-------------QLPPDPPSPPSQPPTPATAPSTTEVP 342
+ +G P + PP P PPSP P TP + T
Sbjct: 1209 LATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPA 1268
Query: 343 PPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAE 402
P +L L A KG A + K A K A
Sbjct: 1269 ATPPSLKGGL-----------ATPPHKGAPNPAVVTPPSPKG-GPATSPPKGAPTPPAAT 1316
Query: 403 LPVP---PGFPPIQGLEATKP--TQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPV 457
P P PG PP +G T P T S G + GP P + P
Sbjct: 1317 PPSPKGSPGTPPPKG-APTPPAVTPPSPKGTPTLPATTPSSKGGP-----TTPSSKEGPT 1370
Query: 458 APTAQP--KAPPSRTPQSGSAPTAKAPPKATST 488
P A P K P+ TP S A PK T
Sbjct: 1371 PPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPT 1403
Score = 47.4 bits (111), Expect = 6e-05
Identities = 71/312 (22%), Positives = 97/312 (31%), Gaps = 51/312 (16%)
Query: 193 PPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPC 252
P V P P SP P P A+ P P+ + P + P + P P
Sbjct: 1289 PAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPT 1348
Query: 253 SPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLP 312
P A + + G TT +++ + +G P +
Sbjct: 1349 LP---------------ATTPSSKGGPTTPSSKEGPTPPA----ATPSHKGGP----AMT 1385
Query: 313 PPPDQLPPDPPSPPSQPPTPATAP-STTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGD 371
PP + P PSP P +PA P S + P P T A SKGD
Sbjct: 1386 PPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTR-------------EGAATPSKGD 1432
Query: 372 QRKARMHERIVKQYQDAIRAHKAGRAVD--------VAELPVPPGFPPI--QGLEATKPT 421
+ +K+ A A K G A A P P PP Q ++ P
Sbjct: 1433 LTPPAVTPVSLKK-APATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPK 1491
Query: 422 QQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTA---QPKAPPSRTPQSGSAPT 478
+ A L E P + P+APTA K P + P+ P
Sbjct: 1492 KAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPP 1551
Query: 479 AKAPPKATSTRA 490
A P T A
Sbjct: 1552 AMTVPSPKKTPA 1563
Score = 42.4 bits (98), Expect = 0.002
Identities = 68/252 (26%), Positives = 86/252 (34%), Gaps = 35/252 (13%)
Query: 121 PPPVAQPKP-EAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLAS 179
PP V P P EAP P T + + G LK AS
Sbjct: 1602 PPAVTSPSPKEAPTPPAVTPPSP-----EKGPATPAPKGTPTSPPVTPSSLKDSPTSPAS 1656
Query: 180 I--RKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGP-----S 232
+ + G + +A P KGP + AP + I +AP T +GP S
Sbjct: 1657 VTCKMGATVPQASKGLPAK--KGPTALKEVLVAPAPESTPIITAP----TRKGPQTKKSS 1710
Query: 233 ATAPASSPGLAKPQMPPGPCS---PGPLAQLQ------------SRQRDYKLAALHAKQQ 277
AT+P P + GP S P PL +Q S LA +K
Sbjct: 1711 ATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKAS 1770
Query: 278 GDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPS 337
TAAA + K A + A + PV L P P LPP PS P +PS
Sbjct: 1771 TPLTAAAFEKVLPKPESASVSA-APSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPS 1829
Query: 338 TTEVPPPPRTLL 349
P LL
Sbjct: 1830 KPLAPADEDELL 1841
Score = 38.5 bits (88), Expect = 0.030
Identities = 98/489 (20%), Positives = 161/489 (32%), Gaps = 77/489 (15%)
Query: 179 SIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASA-PEPRVTLEGPSATAPA 237
S KG + + PP P PT PA T P+P A P P+ T
Sbjct: 1588 STYKGAPSPKELLIPPAVTSPSPKEAPT-PPAVTPPSPEKGPATPAPKGT---------P 1637
Query: 238 SSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVL 297
+SP + + P SP A++ K A++ K A+
Sbjct: 1638 TSPPVTPSSLKDSPTSP---------------ASVTCKMGATVPQASKGLPAKKGPTALK 1682
Query: 298 EALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPP--------TPATAPSTTEVPPPPRTLL 349
E L P + P + P S + PP + P +T P P LL
Sbjct: 1683 EVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAP---LL 1739
Query: 350 EALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGF 409
+ + + A KG + + V+ P PP
Sbjct: 1740 PVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVS 1799
Query: 410 PPI--QGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVA--------- 458
P+ + P QQ L ++ ++ P DE++ +P P++
Sbjct: 1800 LPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVL 1859
Query: 459 ---PTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLAFLE--------GRKKQLLQA 507
PT + P TP + T T + + + + LE ++ QL A
Sbjct: 1860 VNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAA 1919
Query: 508 A-------LRAKQKNDVEGA-----KMHLRQAKGLEPMLEASRNGLPVDITK--VPPAPV 553
A +AKQ + A K+ LRQ G+ + + ITK V +P
Sbjct: 1920 AEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPA 1979
Query: 554 NKDDFALVQRPGPGLSQEAARRYGELTKLIRQQHEMCLNHSNQFTQLGNITETTKFEKLA 613
+ + LSQ+A E K+ + +++ + TQ + E ++ E++
Sbjct: 1980 SDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGE----AVSNIQENTQTPTVQEESEEEEVD 2035
Query: 614 EDCKRSMDI 622
E DI
Sbjct: 2036 ETGVEVKDI 2044
Score = 33.5 bits (75), Expect = 0.97
Identities = 42/153 (27%), Positives = 57/153 (37%), Gaps = 15/153 (9%)
Query: 113 EEQKASETPPPVAQPKPEAPHPG---LETTLQERLALYQTAIESARQAGDSAKMRRYDRG 169
+ +K+S T PP+ P P A + L T L Q + D++ +G
Sbjct: 1705 QTKKSSATSPPIC-PDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHS---PKG 1760
Query: 170 LKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYS------PAPTQPAPRIASAPE 223
AS A E +P P + A +P S P PT P +
Sbjct: 1761 PLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSS 1820
Query: 224 PRVTLEGPSAT-APASSPGLAKPQMPPGPCSPG 255
P + LE PS APA L P +PP P S G
Sbjct: 1821 PGLVLESPSKPLAPADEDELL-PLIPPEPISGG 1852
Score = 31.6 bits (70), Expect = 3.7
Identities = 78/343 (22%), Positives = 122/343 (35%), Gaps = 55/343 (16%)
Query: 167 DRGLKTLENLLASIRKG-NAIDEADIPPPVAI--GKGPASTPTYSPAPTQPAPRIASAPE 223
D+G T+ ++ S N + P ++ P +T Y P + + P
Sbjct: 382 DKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPL 441
Query: 224 PRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAA 283
VT A AP ++ +A PP S GP++ ++ + A A ++ T A
Sbjct: 442 V-VTNPCTIAAAPTTTFEVATCVSPP--MSSGPISNIEPTSPAALVMAPVAPKEPSTQVA 498
Query: 284 ARHFRVAKSFDAVLEALSRGEPVDLSCLP-------PPPDQLPPDPPSPPSQPPTPATAP 336
R+ S +P DL LP P L P S P +PA A
Sbjct: 499 TT-LRIPVSPPLP-------DPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAG 550
Query: 337 STTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGR 396
TT+ P L++A + +Q ++ + + +A A K+
Sbjct: 551 LTTKKDPTVLPLVQAAPKNSPSFQSTSSSPE--------------IPLSPEATLAKKS-- 594
Query: 397 AVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSP 456
+ E P+P G P + S +GV +A + D P ++S
Sbjct: 595 ---LGE-PLPIGKP--------ASSMTSPLGVNSSASVIKTDSYAGPDSAG--PLLKSSL 640
Query: 457 VAPTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLAFLEG 499
+ PT S P +G APT K TST FLEG
Sbjct: 641 ITPTVAAFPLESADP-AGVAPTT---AKGTSTYTTTASPFLEG 679
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 58.5 bits (140), Expect = 3e-08
Identities = 115/519 (22%), Positives = 175/519 (33%), Gaps = 93/519 (17%)
Query: 112 GEEQKASETPPPVAQPKP--------EAPHPGLETTLQ---ERLALYQTAIESARQAGDS 160
G E+ +SE P P A +P + P P T Q + Q ++S +A
Sbjct: 377 GSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGP 436
Query: 161 AKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIAS 220
K G + A K +A PP + GPA P P P +P P+
Sbjct: 437 TKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQL-PGPAKPPPQQPGPAKPPPQQPG 495
Query: 221 APEPRVTLEGPSATAPASSPGLAKPQ-MPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGD 279
+ +P P+ PG KP PGP P P ++ ++Q G
Sbjct: 496 SAKP-----------PSQQPGSTKPPPQQPGPAKPSPQQPGSTKP--------PSQQPGS 536
Query: 280 TTAAARHFRVAKSFDAVLEALSRGEPVDL--SCLPPPPDQLPPDPPSPPSQ--PPTPATA 335
+A+ AK A +PV S P P + P PPSQ P T
Sbjct: 537 AKPSAQQPSPAKP-----SAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPL 591
Query: 336 PSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAG 395
+TTE+ LL E+ H VK++ K
Sbjct: 592 CNTTEL------LLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRA 645
Query: 396 RAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNS 455
D+A +P P Q T P V K + Q + ++D PK+
Sbjct: 646 LGGDLAPVPSSP-----QPKLKTAP-----VTTTSAVSKSSPQPQQTSPKKDAAPKQD-- 693
Query: 456 PVAPTAQPKAPPS--RTPQSGSAPTAK-------------APPKATSTRAQQQLAFLEGR 500
++ +PK PP + P +P+AK APPK S ++Q A +
Sbjct: 694 -LSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADD 752
Query: 501 KKQL---------LQAALRAKQKNDVEGAKMHLRQAKGLEPMLEAS----RNGLPVDITK 547
K + L ++ A K D+ +K+ + + P L+ P K
Sbjct: 753 KPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEK 812
Query: 548 VPP-----APVNKDDFALVQRPGPGLSQEAARRYGELTK 581
V P P D ++ PGP + ++ + K
Sbjct: 813 VSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQK 851
Score = 46.6 bits (109), Expect = 1e-04
Identities = 19/41 (46%), Positives = 22/41 (53%)
Query: 302 RGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVP 342
R +D+S PPPP PP PP PP PP P P T+ P
Sbjct: 2395 RSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKP 2435
Score = 43.9 bits (102), Expect = 7e-04
Identities = 44/167 (26%), Positives = 59/167 (35%), Gaps = 26/167 (15%)
Query: 201 PASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQL 260
P+ +P+ S P +P P S+ +L+ SA P P P PP P P PL
Sbjct: 2377 PSGSPSVSSLPAKPRPFFRSS-----SLD-ISAQPPPPPPPPPPPPPPPPPPPPPPLPPP 2430
Query: 261 QSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSC------LPPP 314
S + L T A F + + S G PV C +PP
Sbjct: 2431 TSPKPTI-LPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPK 2489
Query: 315 PDQLP--------PDPPSPPSQPPT-----PATAPSTTEVPPPPRTL 348
P +P P+P PP P P T T++ P P L
Sbjct: 2490 PSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGL 2536
Score = 42.4 bits (98), Expect = 0.002
Identities = 71/304 (23%), Positives = 101/304 (33%), Gaps = 44/304 (14%)
Query: 205 PTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSP--GPLAQLQS 262
P P +P P+ + +G + + P K Q PPG P GP Q+
Sbjct: 209 PPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQ-PPGTGKPIQGPT---QT 264
Query: 263 RQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPP--PPDQLPP 320
Q D+ L T K D V RGE V S P PP Q P
Sbjct: 265 PQTDHAKLPLQRDASRPQT---------KQADIV-----RGESVKPSLPSPSKPPIQQPT 310
Query: 321 DPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQR-------MERYQVAAAQAKSKGDQR 373
P QP + P + P P L + L Q+ ++ A+ G +
Sbjct: 311 PGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAK 370
Query: 374 KARMHERIVKQYQDAIRAHKAGRAVDVAELPVP---PGFPPIQGLEATKPTQQSLVGVLE 430
K + + V + P P PP Q + KP Q L+
Sbjct: 371 PPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQ--PGLQ 428
Query: 431 TAMKLANQDEGPEDE--EDEVPKKQNSPVAPTAQ---PKAPPSRTPQSGSAP-----TAK 480
+ K + P + ++P +Q P +AQ P PPS+ P P AK
Sbjct: 429 SPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAK 488
Query: 481 APPK 484
PP+
Sbjct: 489 PPPQ 492
Score = 39.3 bits (90), Expect = 0.018
Identities = 91/381 (23%), Positives = 123/381 (32%), Gaps = 90/381 (23%)
Query: 120 TPPPVAQPKPE---APHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENL 176
TP ++ +PE + PG +Q QT D AK+ R +
Sbjct: 235 TPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQT---------DHAKLP-LQRDASRPQTK 284
Query: 177 LASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSA-TA 235
A I +G ++ + +P P K P PT P Q S P P PS T
Sbjct: 285 QADIVRGESV-KPSLPSP---SKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTK 340
Query: 236 P-ASSPGLAKPQM-PPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSF 293
P A PG KP + PPG P P L A A+Q G ++
Sbjct: 341 PLAQQPGTVKPPVQPPGTTKP-PAQPLGP-------AKPPAQQTGSEKPSSEQ------- 385
Query: 294 DAVLEALSRGEPVDLSCLPPPPDQL--PPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEA 351
P P L PP P+Q P PA P+ P P
Sbjct: 386 -------------------PGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPG 426
Query: 352 LEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPP 411
L+ + AK+ G + + + I A +AG PG
Sbjct: 427 LQ----------SPAKAPGPTKTP-----VQQPGPGKIPAQQAG-----------PGKTS 460
Query: 412 IQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTP 471
Q TKP Q L K Q GP P++ S P+ QP +
Sbjct: 461 AQQTGPTKPPSQ-----LPGPAKPPPQQPGPAKPP---PQQPGSAKPPSQQPGSTKPPPQ 512
Query: 472 QSGSAPTAKAPPKATSTRAQQ 492
Q G A + P +T +QQ
Sbjct: 513 QPGPAKPSPQQPGSTKPPSQQ 533
Score = 38.9 bits (89), Expect = 0.023
Identities = 107/528 (20%), Positives = 175/528 (33%), Gaps = 100/528 (18%)
Query: 187 DEADIP--PPVAIGKGPASTPTY----SPAPTQPAPR--------IASAPEPRV------ 226
D A +P P + P +T + SP P Q +P+ ++ APEP+
Sbjct: 649 DLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVK 708
Query: 227 --TLEG-PSATA--PASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTT 281
TL G PSA A P + L+KP P P P S Q +A KQ
Sbjct: 709 QPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVP-------SEQDKAPVADDKPKQPK--- 758
Query: 282 AAARHFRVAKSFDAVLEALSRGEP-VDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTE 340
V + D V + + +P + S + ++ P S P+ + P+ +
Sbjct: 759 ------MVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEK 812
Query: 341 VPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDV 400
V P + + ++SKG ++ + ++ + + K
Sbjct: 813 VSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMP 872
Query: 401 AELPVPPGFPPIQGL------EATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKK-- 452
P PPG P G ++ KP +QS L P ++ V K
Sbjct: 873 KGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLF 932
Query: 453 --------QNSPVAPTAQ---------PKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLA 495
Q S + TA P AP + P PT++ PPK+T
Sbjct: 933 GFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAK 992
Query: 496 FLEGRKKQLLQAALRAKQK---------NDVEGAKMHLRQAKGLEPMLEASRNGLPVDIT 546
+ +K+ AA + + K + E ++ +K L E + LP +
Sbjct: 993 SIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSL--TAEPQKAVLPTKLE 1050
Query: 547 KVP----PAPVNKDDFALVQRPGPGLSQEAARR--------YGELTKLIRQQHEMCLNHS 594
K P P+ K + + + P + + + L Q +CLN
Sbjct: 1051 KSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQ 1110
Query: 595 NQFTQLGNITETTKFEKLAEDCKRSMDILKQAFVRGLPTPTARFEQRT 642
Q G + + K K S +P PT Q+T
Sbjct: 1111 TQRAISGQLGDIRKMPPAPSGPKAS----------PMPVPTESSSQKT 1148
Score = 35.0 bits (79), Expect = 0.33
Identities = 73/367 (19%), Positives = 126/367 (34%), Gaps = 67/367 (18%)
Query: 317 QLPPDPPSPPSQP-PTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKA 375
++PP P P + P P P + S PP L++ EQ ++ K K
Sbjct: 1124 KMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSME 1183
Query: 376 RMHERIV---KQYQDAIRAHKAGRAVDVAELPVPPGFPPIQG----------LEATKPTQ 422
++ + KQ + + KA + LP P + LE KPT
Sbjct: 1184 KIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTP 1243
Query: 423 QSLVGVLETAMKLANQDEGPEDEEDEVPKKQ--------NSPVAPTA-----QPKAP--- 466
+ + E + PE+++ ++ K Q VAP QP+
Sbjct: 1244 EDKKLLPEA------KTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEG 1297
Query: 467 -PSRTPQSGSAPTAKAPPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLR 525
PS TPQS K K T T +Q + Q ++ +K D + +
Sbjct: 1298 LPSGTPQS----LPKEDDKTTKTIKEQPQPPCTAKPDQ-VEPGKEKTEKEDDKSDTSSSQ 1352
Query: 526 QAKGLEPMLEA--SRNGLPVDITKVPP----------APVNKDDFALVQRPGPG------ 567
Q K + + + S +G+ + ++P + KD F+ P
Sbjct: 1353 QPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKL 1412
Query: 568 -------LSQEAARRYGELTKLIRQQHEMCLNHSNQFTQLGNITETTKFEKLAEDCKRSM 620
L +A+ E ++ Q HE+ + +++ET + E+ K S
Sbjct: 1413 ESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQ 1472
Query: 621 DILKQAF 627
+ K F
Sbjct: 1473 EERKDTF 1479
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 58.5 bits (140), Expect = 3e-08
Identities = 115/519 (22%), Positives = 175/519 (33%), Gaps = 93/519 (17%)
Query: 112 GEEQKASETPPPVAQPKP--------EAPHPGLETTLQ---ERLALYQTAIESARQAGDS 160
G E+ +SE P P A +P + P P T Q + Q ++S +A
Sbjct: 377 GSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGP 436
Query: 161 AKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIAS 220
K G + A K +A PP + GPA P P P +P P+
Sbjct: 437 TKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQL-PGPAKPPPQQPGPAKPPPQQPG 495
Query: 221 APEPRVTLEGPSATAPASSPGLAKPQ-MPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGD 279
+ +P P+ PG KP PGP P P ++ ++Q G
Sbjct: 496 SAKP-----------PSQQPGSTKPPPQQPGPAKPSPQQPGSTKP--------PSQQPGS 536
Query: 280 TTAAARHFRVAKSFDAVLEALSRGEPVDL--SCLPPPPDQLPPDPPSPPSQ--PPTPATA 335
+A+ AK A +PV S P P + P PPSQ P T
Sbjct: 537 AKPSAQQPSPAKP-----SAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPL 591
Query: 336 PSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAG 395
+TTE+ LL E+ H VK++ K
Sbjct: 592 CNTTEL------LLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRA 645
Query: 396 RAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNS 455
D+A +P P Q T P V K + Q + ++D PK+
Sbjct: 646 LGGDLAPVPSSP-----QPKLKTAP-----VTTTSAVSKSSPQPQQTSPKKDAAPKQD-- 693
Query: 456 PVAPTAQPKAPPS--RTPQSGSAPTAK-------------APPKATSTRAQQQLAFLEGR 500
++ +PK PP + P +P+AK APPK S ++Q A +
Sbjct: 694 -LSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADD 752
Query: 501 KKQL---------LQAALRAKQKNDVEGAKMHLRQAKGLEPMLEAS----RNGLPVDITK 547
K + L ++ A K D+ +K+ + + P L+ P K
Sbjct: 753 KPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEK 812
Query: 548 VPP-----APVNKDDFALVQRPGPGLSQEAARRYGELTK 581
V P P D ++ PGP + ++ + K
Sbjct: 813 VSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQK 851
Score = 46.6 bits (109), Expect = 1e-04
Identities = 19/41 (46%), Positives = 22/41 (53%)
Query: 302 RGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVP 342
R +D+S PPPP PP PP PP PP P P T+ P
Sbjct: 2395 RSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKP 2435
Score = 43.9 bits (102), Expect = 7e-04
Identities = 44/167 (26%), Positives = 59/167 (35%), Gaps = 26/167 (15%)
Query: 201 PASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQL 260
P+ +P+ S P +P P S+ +L+ SA P P P PP P P PL
Sbjct: 2377 PSGSPSVSSLPAKPRPFFRSS-----SLD-ISAQPPPPPPPPPPPPPPPPPPPPPPLPPP 2430
Query: 261 QSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSC------LPPP 314
S + L T A F + + S G PV C +PP
Sbjct: 2431 TSPKPTI-LPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPK 2489
Query: 315 PDQLP--------PDPPSPPSQPPT-----PATAPSTTEVPPPPRTL 348
P +P P+P PP P P T T++ P P L
Sbjct: 2490 PSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGL 2536
Score = 42.4 bits (98), Expect = 0.002
Identities = 71/304 (23%), Positives = 101/304 (33%), Gaps = 44/304 (14%)
Query: 205 PTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSP--GPLAQLQS 262
P P +P P+ + +G + + P K Q PPG P GP Q+
Sbjct: 209 PPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQ-PPGTGKPIQGPT---QT 264
Query: 263 RQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPP--PPDQLPP 320
Q D+ L T K D V RGE V S P PP Q P
Sbjct: 265 PQTDHAKLPLQRDASRPQT---------KQADIV-----RGESVKPSLPSPSKPPIQQPT 310
Query: 321 DPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQR-------MERYQVAAAQAKSKGDQR 373
P QP + P + P P L + L Q+ ++ A+ G +
Sbjct: 311 PGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAK 370
Query: 374 KARMHERIVKQYQDAIRAHKAGRAVDVAELPVP---PGFPPIQGLEATKPTQQSLVGVLE 430
K + + V + P P PP Q + KP Q L+
Sbjct: 371 PPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQ--PGLQ 428
Query: 431 TAMKLANQDEGPEDE--EDEVPKKQNSPVAPTAQ---PKAPPSRTPQSGSAP-----TAK 480
+ K + P + ++P +Q P +AQ P PPS+ P P AK
Sbjct: 429 SPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAK 488
Query: 481 APPK 484
PP+
Sbjct: 489 PPPQ 492
Score = 39.3 bits (90), Expect = 0.018
Identities = 91/381 (23%), Positives = 123/381 (32%), Gaps = 90/381 (23%)
Query: 120 TPPPVAQPKPE---APHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENL 176
TP ++ +PE + PG +Q QT D AK+ R +
Sbjct: 235 TPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQT---------DHAKLP-LQRDASRPQTK 284
Query: 177 LASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSA-TA 235
A I +G ++ + +P P K P PT P Q S P P PS T
Sbjct: 285 QADIVRGESV-KPSLPSP---SKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTK 340
Query: 236 P-ASSPGLAKPQM-PPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSF 293
P A PG KP + PPG P P L A A+Q G ++
Sbjct: 341 PLAQQPGTVKPPVQPPGTTKP-PAQPLGP-------AKPPAQQTGSEKPSSEQ------- 385
Query: 294 DAVLEALSRGEPVDLSCLPPPPDQL--PPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEA 351
P P L PP P+Q P PA P+ P P
Sbjct: 386 -------------------PGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPG 426
Query: 352 LEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPP 411
L+ + AK+ G + + + I A +AG PG
Sbjct: 427 LQ----------SPAKAPGPTKTP-----VQQPGPGKIPAQQAG-----------PGKTS 460
Query: 412 IQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTP 471
Q TKP Q L K Q GP P++ S P+ QP +
Sbjct: 461 AQQTGPTKPPSQ-----LPGPAKPPPQQPGPAKPP---PQQPGSAKPPSQQPGSTKPPPQ 512
Query: 472 QSGSAPTAKAPPKATSTRAQQ 492
Q G A + P +T +QQ
Sbjct: 513 QPGPAKPSPQQPGSTKPPSQQ 533
Score = 38.9 bits (89), Expect = 0.023
Identities = 107/528 (20%), Positives = 175/528 (33%), Gaps = 100/528 (18%)
Query: 187 DEADIP--PPVAIGKGPASTPTY----SPAPTQPAPR--------IASAPEPRV------ 226
D A +P P + P +T + SP P Q +P+ ++ APEP+
Sbjct: 649 DLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVK 708
Query: 227 --TLEG-PSATA--PASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTT 281
TL G PSA A P + L+KP P P P S Q +A KQ
Sbjct: 709 QPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVP-------SEQDKAPVADDKPKQPK--- 758
Query: 282 AAARHFRVAKSFDAVLEALSRGEP-VDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTE 340
V + D V + + +P + S + ++ P S P+ + P+ +
Sbjct: 759 ------MVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEK 812
Query: 341 VPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDV 400
V P + + ++SKG ++ + ++ + + K
Sbjct: 813 VSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMP 872
Query: 401 AELPVPPGFPPIQGL------EATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKK-- 452
P PPG P G ++ KP +QS L P ++ V K
Sbjct: 873 KGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLF 932
Query: 453 --------QNSPVAPTAQ---------PKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLA 495
Q S + TA P AP + P PT++ PPK+T
Sbjct: 933 GFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAK 992
Query: 496 FLEGRKKQLLQAALRAKQK---------NDVEGAKMHLRQAKGLEPMLEASRNGLPVDIT 546
+ +K+ AA + + K + E ++ +K L E + LP +
Sbjct: 993 SIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSL--TAEPQKAVLPTKLE 1050
Query: 547 KVP----PAPVNKDDFALVQRPGPGLSQEAARR--------YGELTKLIRQQHEMCLNHS 594
K P P+ K + + + P + + + L Q +CLN
Sbjct: 1051 KSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQ 1110
Query: 595 NQFTQLGNITETTKFEKLAEDCKRSMDILKQAFVRGLPTPTARFEQRT 642
Q G + + K K S +P PT Q+T
Sbjct: 1111 TQRAISGQLGDIRKMPPAPSGPKAS----------PMPVPTESSSQKT 1148
Score = 35.0 bits (79), Expect = 0.33
Identities = 73/367 (19%), Positives = 126/367 (34%), Gaps = 67/367 (18%)
Query: 317 QLPPDPPSPPSQP-PTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKA 375
++PP P P + P P P + S PP L++ EQ ++ K K
Sbjct: 1124 KMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSME 1183
Query: 376 RMHERIV---KQYQDAIRAHKAGRAVDVAELPVPPGFPPIQG----------LEATKPTQ 422
++ + KQ + + KA + LP P + LE KPT
Sbjct: 1184 KIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTP 1243
Query: 423 QSLVGVLETAMKLANQDEGPEDEEDEVPKKQ--------NSPVAPTA-----QPKAP--- 466
+ + E + PE+++ ++ K Q VAP QP+
Sbjct: 1244 EDKKLLPEA------KTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEG 1297
Query: 467 -PSRTPQSGSAPTAKAPPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLR 525
PS TPQS K K T T +Q + Q ++ +K D + +
Sbjct: 1298 LPSGTPQS----LPKEDDKTTKTIKEQPQPPCTAKPDQ-VEPGKEKTEKEDDKSDTSSSQ 1352
Query: 526 QAKGLEPMLEA--SRNGLPVDITKVPP----------APVNKDDFALVQRPGPG------ 567
Q K + + + S +G+ + ++P + KD F+ P
Sbjct: 1353 QPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKL 1412
Query: 568 -------LSQEAARRYGELTKLIRQQHEMCLNHSNQFTQLGNITETTKFEKLAEDCKRSM 620
L +A+ E ++ Q HE+ + +++ET + E+ K S
Sbjct: 1413 ESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQ 1472
Query: 621 DILKQAF 627
+ K F
Sbjct: 1473 EERKDTF 1479
>gi|60460889 Myb protein P42POP [Homo sapiens]
Length = 399
Score = 57.4 bits (137), Expect = 6e-08
Identities = 67/241 (27%), Positives = 94/241 (39%), Gaps = 35/241 (14%)
Query: 118 SETPP--PVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLEN 175
+E PP P +QP P + P +R L + E R+A SA + +
Sbjct: 133 AEEPPAAPSSQPPPPSACP-------QRYVLSEDRRED-RRADTSAHSKAGSSSPEPWAR 184
Query: 176 LLASIRKGNAI--DEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSA 233
+ ++G E + PPP A+ P P + +P PAP + P P + PS
Sbjct: 185 PSCTPQEGGCPRPKERESPPPSALQ--PVQLPRLALSPPPPAPPLP--PPPPLAQVAPS- 239
Query: 234 TAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSF 293
P PP P P P D+ A A +AK
Sbjct: 240 -----------PPSPPPPPRPPPTLSASDPSLDFLRAQQETANAIRELAGTLRQGLAKLS 288
Query: 294 DAV--LEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEA 351
+A+ L L G PVD LPPP PP PP PP +P P AP E+ P P +++ A
Sbjct: 289 EALSALLPLLPGTPVD--SLPPPLP--PPPPPPPPPRPVLPPPAPK-VEITPEPVSVVAA 343
Query: 352 L 352
+
Sbjct: 344 V 344
Score = 51.2 bits (121), Expect = 4e-06
Identities = 80/310 (25%), Positives = 114/310 (36%), Gaps = 59/310 (19%)
Query: 198 GKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPL 257
G GPA+ +S + E + GP AP + G +P P P P
Sbjct: 100 GAGPAAEDAFS-----------AEEETIFAILGPGVAAPGAGAGAEEPPAAPSSQPPPPS 148
Query: 258 AQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSC------- 310
A QR ++ DT+A ++ A S A P + C
Sbjct: 149 A---CPQRYVLSEDRREDRRADTSAHSK----AGSSSPEPWARPSCTPQEGGCPRPKERE 201
Query: 311 LPPP----PDQLP-----PDPPSPPSQPPTP--ATAPSTTEVPPPPR--TLLEALEQRME 357
PPP P QLP P PP+PP PP P APS PPPPR L A + ++
Sbjct: 202 SPPPSALQPVQLPRLALSPPPPAPPLPPPPPLAQVAPSPPSPPPPPRPPPTLSASDPSLD 261
Query: 358 ----RYQVAAAQAKSKGDQRK--ARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPP 411
+ + A A + G R+ A++ E + A+ G VD P+PP PP
Sbjct: 262 FLRAQQETANAIRELAGTLRQGLAKLSEAL-----SALLPLLPGTPVDSLPPPLPPPPPP 316
Query: 412 IQGLEATKPTQQSLVGVL-ETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQ---PKAPP 467
P V + E +A +G V + +AP ++ P+ PP
Sbjct: 317 PPPPRPVLPPPAPKVEITPEPVSVVAAVVDG------AVVAARGVIIAPRSEEGAPRPPP 370
Query: 468 SRTPQSGSAP 477
+ P S P
Sbjct: 371 APLPPHDSPP 380
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
Length = 816
Score = 57.0 bits (136), Expect = 8e-08
Identities = 90/394 (22%), Positives = 136/394 (34%), Gaps = 53/394 (13%)
Query: 121 PPPVAQPKP--EAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLA 178
P P A+P+P E P + + + A AG + R R L + L+
Sbjct: 183 PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ-RPASRSLSSSATPLS 241
Query: 179 SIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPR-IASAPEPRVT---LEGPSAT 234
S P G TP P+QP P+ + + P+VT + A
Sbjct: 242 S--------------PARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 287
Query: 235 APASSPGLA--KPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKS 292
P SS LA P PP P +P L L S Q T+ + + S
Sbjct: 288 GPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPAT-------PPSQATTSLGSPTLQATHS 340
Query: 293 F--DAVLEALSRGEPVDLSCLPPPPDQLPPDPP-SPPSQP---PTP----ATAPSTTEVP 342
F L L+ P L PP Q PP PP SPP P P+P A A + P
Sbjct: 341 FLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAP 400
Query: 343 --PPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDV 400
PPP ++A + A+ S ++ + + A +
Sbjct: 401 FSPPPSPPVQA------PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP 454
Query: 401 AELPVPPGFPPIQG--LEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVA 458
+ P P PP+ L+ KP Q+ + ++ + + P++
Sbjct: 455 SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMS 514
Query: 459 PTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQ 492
P A PP + P +AP + PP ++ Q
Sbjct: 515 PLA---TPPPQAPPVLAAPLLQVPPSPPASPTLQ 545
Score = 54.3 bits (129), Expect = 5e-07
Identities = 97/385 (25%), Positives = 139/385 (36%), Gaps = 67/385 (17%)
Query: 120 TPPPVAQPKPEA----PHP----GLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLK 171
+P PV+ P + P P GL + +E +A + A E+ +++ SA RR G
Sbjct: 101 SPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGK-ATEAPKRSALSAGARRDTSGPT 159
Query: 172 TLENLLASIRKGNAID-EADIPPPVAIGKGPASTPTYSPAPTQPAPR--IASAPEPRVTL 228
A R+ A E +P P P+ P P PR ++SA E T
Sbjct: 160 PGTPSPAMARRSRAAGTEVGLPRPA---------PSARPRPPTEGPRKSVSSASEHSTTE 210
Query: 229 EGPSATA-PASSPGLAKPQMPPGPCSPGPL---AQLQSRQRDYKLAALHAKQ-QGDTTAA 283
P+A P++ GL +P S PL A+ R A H Q + A
Sbjct: 211 PSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQA 270
Query: 284 ARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQ---PPTPATAPS--T 338
R +V AL P+ S L P PP P +PPS P PAT PS T
Sbjct: 271 LRPPQVTPPRKDAAPALG---PLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQAT 327
Query: 339 TEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAV 398
T + P L+A + ++ +A A
Sbjct: 328 TSLGSPT---LQATHSFLPSPPLSPLATPPP--------------------QAPPALALP 364
Query: 399 DVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVA 458
+ P PP PP+ L P + + V + + P P + +P +
Sbjct: 365 PLQAPPSPPASPPLSPLATPSPQAPNALAV--------HLLQAPFSPPPSPPVQ--APFS 414
Query: 459 PTAQPKAPPSRTPQSGSAPTAKAPP 483
P A P PS TP S + P+ APP
Sbjct: 415 PPASPPVSPSATPPSQAPPSLAAPP 439
Score = 53.9 bits (128), Expect = 7e-07
Identities = 78/296 (26%), Positives = 109/296 (36%), Gaps = 75/296 (25%)
Query: 110 VLGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRG 169
V + ++ P P A+ +P A GL+ L+ T + S ++G SA RG
Sbjct: 200 VSSASEHSTTEPSPAARRRPSAGG-GLQRPASRSLSSSATPLSSPARSGPSA------RG 252
Query: 170 LKTLENLLASIR-KG-NAIDEADIPPP---VAIGKGP-ASTPTYSPAPTQPAPRIASAPE 223
+ + KG A+ + PP A GP +S+P +P+P+ AP SAP
Sbjct: 253 TPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPS--APPSPSAPP 310
Query: 224 PRVTLEGPSATAPASS--------------------------------PGLAKP--QMPP 249
TL P AT P+ + P LA P Q PP
Sbjct: 311 SLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPP 370
Query: 250 GPCSPGPLAQLQSRQRDYKLA-ALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDL 308
P + PL+ L + A A+H Q + + + S A PV
Sbjct: 371 SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA-------SPPVSP 423
Query: 309 SCLPP---------PPDQLPPDPPS---------PPSQPPTPATAPSTTEVPPPPR 346
S PP PP Q+PP PP+ PP Q P P AP PPP+
Sbjct: 424 SATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQ 479
Score = 49.7 bits (117), Expect = 1e-05
Identities = 77/297 (25%), Positives = 110/297 (37%), Gaps = 37/297 (12%)
Query: 198 GKGPASTPTYSP--APTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPG 255
G G A+ P +P PT+ + AS R ++ P SSPG A PGP
Sbjct: 64 GIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQK 123
Query: 256 PLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEAL---SRGEPVDLSCLP 312
L ++ + + + A A ++ +A AR + A+ SR ++
Sbjct: 124 GL-RISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPR 182
Query: 313 PPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQ 372
P P P P P + + A+ STTE P R A G Q
Sbjct: 183 PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSA----------------GGGLQ 226
Query: 373 RKA-RMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLET 431
R A R R+ + R A P P P +GL+A +P Q +
Sbjct: 227 RPASRSLSSSATPLSSPARSGPSARGTPRA--PAHPSQPKPKGLQALRPPQ------VTP 278
Query: 432 AMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATST 488
K A GP P SP AP + P APPS Q+ +P A P +AT++
Sbjct: 279 PRKDAAPALGPLSSS---PLATPSPSAPPS-PSAPPSL--QTLPSPPATPPSQATTS 329
Score = 46.6 bits (109), Expect = 1e-04
Identities = 44/169 (26%), Positives = 63/169 (37%), Gaps = 16/169 (9%)
Query: 193 PPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPC 252
PPV P ++P SP+ T P+ S P + + +P SP P P P
Sbjct: 407 PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPL 466
Query: 253 SPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVL--EALSRGEPVDLSC 310
+ PL + + A Q + A+ + S A L L+ P
Sbjct: 467 AAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV 526
Query: 311 LPPPPDQLPPDPPSPPS-----QPPTPATAPSTT---------EVPPPP 345
L P Q+PP PP+ P+ +PPTP S + PPPP
Sbjct: 527 LAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 575
Score = 37.0 bits (84), Expect = 0.088
Identities = 41/170 (24%), Positives = 60/170 (35%), Gaps = 25/170 (14%)
Query: 188 EADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQM 247
+A P ++ P +TP P AP + P +P +SP L P+
Sbjct: 502 QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPP------------SPPASPTLQAPRR 549
Query: 248 PPGPCSPGPLAQLQSRQRDYKLA----ALHAKQQGDTTAA---ARHFRVAKSFDAVLEAL 300
PP +PGP + + LA ++ T + A H A S L
Sbjct: 550 PP---TPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGY 606
Query: 301 SRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATA---PSTTEVPPPPRT 347
G + PPP +L P+ S+ P P A +P PP T
Sbjct: 607 DSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPAT 656
Score = 35.8 bits (81), Expect = 0.20
Identities = 40/154 (25%), Positives = 55/154 (35%), Gaps = 20/154 (12%)
Query: 192 PPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEG-----PSATAPASSPGLAKPQ 246
PPP+A + P P P + + P P + G PSA+ P S PQ
Sbjct: 463 PPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ 522
Query: 247 MPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPV 306
PP +P LQ L A ++ T + S + AL+ G
Sbjct: 523 APPVLAAP----LLQVPPSPPASPTLQAPRRPPTPGP----DTSVSGPRLTLALAPGP-- 572
Query: 307 DLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTE 340
PPPP + P S P ++A ST E
Sbjct: 573 -----PPPPSRSPSSTLSGPDLAGHSSSATSTPE 601
>gi|112421108 capicua homolog [Homo sapiens]
Length = 1608
Score = 55.5 bits (132), Expect = 2e-07
Identities = 62/218 (28%), Positives = 84/218 (38%), Gaps = 36/218 (16%)
Query: 186 IDEADIPPPVAIGKGPASTPTYS--PAPTQPAP--RIASAPEPRVTLEGPSATAPASSPG 241
+ +PP A GP T YS PAPT AP + + AP V S T PA++
Sbjct: 1075 VPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAATIL 1134
Query: 242 LAKPQMP----PGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAK----SF 293
P P P P SP P A S Y L A A++ +A SF
Sbjct: 1135 PKGPPAPATATPAPTSPFPSATAGSMT--YSLVAPKAQRPSPKAPQKVKAAIASIPVGSF 1192
Query: 294 DAVLEALSRGEPVDLSCLPPPPDQLPPDP-------PSPPSQPPTP----ATAPSTTEVP 342
+A A R P L P P + P P P+PP+ PP P TA S+ +P
Sbjct: 1193 EA--GASGRPGPAPRQPLEPGPVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLP 1250
Query: 343 PP---------PRTLLEALEQRMERYQVAAAQAKSKGD 371
PP P T+ ++V +++G+
Sbjct: 1251 PPAEERTSAKGPETMASKFPSSSSDWRVPGQGLENRGE 1288
Score = 42.4 bits (98), Expect = 0.002
Identities = 92/418 (22%), Positives = 135/418 (32%), Gaps = 78/418 (18%)
Query: 115 QKASETPPPVAQPKP--EAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKT 172
Q PPP AQ +AP PG L L A S G A + L
Sbjct: 890 QSVPSAPPPKAQSVSPVQAPPPGGSAQLLPGKVLVPLAAPSMSVRGGGA-----GQPLPL 944
Query: 173 LENLLASIRKGNAIDEADI----PPPVAIGKG--PASTPTYSPAPTQPAPRIASAPEPRV 226
+ + + A + I P PV+ G P +P P PT ++ R+
Sbjct: 945 VSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLLPSSTRI 1004
Query: 227 TLEG-------PSATAPASSPGLAKPQMPP-----------GPCSPGPLAQLQSRQRDYK 268
T P T+PASS P GP P + L S +
Sbjct: 1005 TYVQSAGGHALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGPSGPAFVQPLLSAGQAPL 1064
Query: 269 LAALHAKQQGDTTAAARHFRVAKSFDA--VLEALSRGEPVDLSCLP-PPPDQLPPD---- 321
LA Q G + + A + V+ A G P S P P Q PP
Sbjct: 1065 LAP---GQVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYT 1121
Query: 322 ---PPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMH 378
+PP+ P P+ P P + + Y + A +A+ + ++
Sbjct: 1122 VATSTTPPAATILPKGPPAPATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVK 1181
Query: 379 ERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQ 438
I + A +GR P+ PG P++ +PT
Sbjct: 1182 AAIASIPVGSFEAGASGRPGPAPRQPLEPG--PVR-----EPT----------------- 1217
Query: 439 DEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAP-PKATSTRAQQQLA 495
PE E + P P A P P + TP + S+P P + TS + + +A
Sbjct: 1218 --APESELEGQP-------TPPAPPPLPETWTPTARSSPPLPPPAEERTSAKGPETMA 1266
Score = 36.2 bits (82), Expect = 0.15
Identities = 84/387 (21%), Positives = 127/387 (32%), Gaps = 60/387 (15%)
Query: 117 ASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAK--MRRYDRGLKTLE 174
A+ T PP A P+ P P T + + +A + A R + + ++
Sbjct: 1123 ATSTTPPAATILPKGP-PAPATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVK 1181
Query: 175 NLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEG-PSA 233
+ASI G+ A P GPA P P R +APE LEG P+
Sbjct: 1182 AAIASIPVGSFEAGASGRP------GPAPRQPLEPGPV----REPTAPESE--LEGQPTP 1229
Query: 234 TAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSF 293
AP P P P P P + S + +A+ D +
Sbjct: 1230 PAPPPLPETWTPTARSSPPLPPPAEERTSAKGPETMASKFPSSSSDWRVPGQGLE----- 1284
Query: 294 DAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALE 353
+RGEP P PPSP P PA AP + R + E
Sbjct: 1285 -------NRGEP--------------PTPPSP---APAPAVAPGGSSESSSGRAAGDTPE 1320
Query: 354 QRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQ 413
++ ++ G +K ++ +K+ D++ P F P +
Sbjct: 1321 RK-----------EAAGTGKKVKVRPPPLKKTFDSVDNRVLSEVDFEERFAELPEFRPEE 1369
Query: 414 GLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPS--RTP 471
L + PT QSL + + + D P+ SP + + S TP
Sbjct: 1370 VLPS--PTLQSLATSPRAILGSYRKKRKNSTDLDSAPEDPTSPKRKMRRRSSCSSEPNTP 1427
Query: 472 QSGSAPTAKAPPKATSTRAQQQLAFLE 498
+S T T A+ L LE
Sbjct: 1428 KSAKCEGDIFTFDRTGTEAEDVLGELE 1454
Score = 35.4 bits (80), Expect = 0.25
Identities = 51/190 (26%), Positives = 71/190 (37%), Gaps = 35/190 (18%)
Query: 78 SLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPHPGLE 137
S C +P+ + E D+ D E +VLGE + + P+ L
Sbjct: 1418 SSCSSEPNTPKSAKC-EGDIFTFDRTGTEAEDVLGELEY------------DKVPYSSLR 1464
Query: 138 TTLQERLALYQTAIES-----ARQAGDSAKMRRYDRGLKTLENLLASIRK-GNAIDEADI 191
TL +R AL + + QA +A RY + L IR+ I +A
Sbjct: 1465 RTLDQRRALVMQLFQDHGFFPSAQA-TAAFQARYADIFPSKVCLQLKIREVRQKIMQAAT 1523
Query: 192 P---PPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAK---P 245
P PP A P PT + A P P A P+P T+P+S G A+ P
Sbjct: 1524 PTEQPPGAEAPLPVPPPTGTAAAPAPTPSPAGGPDP---------TSPSSDSGTAQAAPP 1574
Query: 246 QMPPGPCSPG 255
PP PG
Sbjct: 1575 LPPPPESGPG 1584
Score = 33.9 bits (76), Expect = 0.74
Identities = 23/64 (35%), Positives = 27/64 (42%), Gaps = 2/64 (3%)
Query: 193 PPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPC 252
PPVA GKG S P S + + PA ASA G + A P PP P
Sbjct: 520 PPVAFGKGYGSAP--SSSASSPASSSASAATSFSLGSGTFKAQESGQGSTAGPLRPPPPG 577
Query: 253 SPGP 256
+ GP
Sbjct: 578 AGGP 581
Score = 33.1 bits (74), Expect = 1.3
Identities = 22/68 (32%), Positives = 29/68 (42%), Gaps = 5/68 (7%)
Query: 191 IPPPVAIGKGPASTPTYS--PAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMP 248
+PPP PA TP+ + P PT P+ +A + L P + P PQ
Sbjct: 1537 VPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTA-QAAPPLPPPPESGPGQPGWEGAPQ-- 1593
Query: 249 PGPCSPGP 256
P P PGP
Sbjct: 1594 PSPPPPGP 1601
Score = 31.2 bits (69), Expect = 4.8
Identities = 42/165 (25%), Positives = 56/165 (33%), Gaps = 23/165 (13%)
Query: 197 IGKGPAS-------TPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPP 249
+GK PA+ TP Y AP PA + + P S S P +P
Sbjct: 753 VGKAPATVTNLLVGTPGYG-APAPPAVQFIAQGAPGGGTTAGSGAGAGSGPN---GPVPL 808
Query: 250 GPCSPGPLAQ----------LQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEA 299
G PG L + L + + ++A A G AA S L
Sbjct: 809 GILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPP 868
Query: 300 LSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPP 344
+ L+ P P P S PS PP A + S + PPP
Sbjct: 869 GTSTNGKVLAATAPTPGI--PILQSVPSAPPPKAQSVSPVQAPPP 911
>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
Length = 2157
Score = 55.1 bits (131), Expect = 3e-07
Identities = 76/290 (26%), Positives = 111/290 (38%), Gaps = 43/290 (14%)
Query: 122 PPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIR 181
PP P PE ++ + A+E AR+ + + R + E A
Sbjct: 435 PPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQE------ERRAACAE 488
Query: 182 KGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPG 241
K +DE P + PA+ P AP+ PAP A E L P A PAS+P
Sbjct: 489 KLKRLDEKFGAPDKRLKAEPAAPPA---APSTPAPPPAVPKE----LPAPPAPPPASAP- 540
Query: 242 LAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALS 301
P+ P + P AQ S AA G +T++ + SF+A
Sbjct: 541 --TPETEPEEPAQAPPAQ--STPTPGVAAAPTLVSGGGSTSSTS----SGSFEA------ 586
Query: 302 RGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQV 361
PV+ LP PP+ PP+ PP P P + P + + L +YQ
Sbjct: 587 --SPVEPQ-LPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGL--GYPKYQ- 640
Query: 362 AAAQAKSKGDQRKARMHERIVKQYQD-AIRAHKAGRAVDVAELPVPPGFP 410
KS + + + E+++KQ Q + H+ G A PVPP P
Sbjct: 641 -----KSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSA---PPTPVPPSPP 682
Score = 48.9 bits (115), Expect = 2e-05
Identities = 65/277 (23%), Positives = 94/277 (33%), Gaps = 59/277 (21%)
Query: 86 EDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPP--PVAQPKPEAPHPGLETTLQER 143
E+EE E+ A + L L+E G K + P P A P AP P + L
Sbjct: 472 EEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAP 531
Query: 144 LA-------LYQTAIESARQAGDSAKMRRYDRGLKTLENLLA-----SIRKGNAIDEADI 191
A +T E QA + G+ L++ S + + + +
Sbjct: 532 PAPPPASAPTPETEPEEPAQAPPAQSTPT--PGVAAAPTLVSGGGSTSSTSSGSFEASPV 589
Query: 192 PPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGP 251
P + +GP P T P P++ EP+ GP+ P+ G K Q
Sbjct: 590 EPQLPSKEGPEPPEEVPPPTTPPVPKV----EPKGDGIGPTRQPPSQGLGYPKYQK---- 641
Query: 252 CSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCL 311
S P Q Q +++ K H QQ +A
Sbjct: 642 -SLPPRFQRQQQEQLLKQQQQHQWQQHQQGSA---------------------------- 672
Query: 312 PPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTL 348
PP +PP PP QP T P+ PPPP+ L
Sbjct: 673 --PPTPVPPSPP----QPVTLGAVPAPQAPPPPPKAL 703
Score = 44.3 bits (103), Expect = 5e-04
Identities = 78/339 (23%), Positives = 112/339 (33%), Gaps = 59/339 (17%)
Query: 193 PPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPG-- 250
PP A GK S + P P + PE P P G A PPG
Sbjct: 370 PPEADGKKGNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPAGNWGPPGDY 429
Query: 251 ------PCSPGPLAQLQS---RQR------DYKLAALHAKQQGD-----------TTAAA 284
PC P P + + RQR + LA A+++ + A
Sbjct: 430 PDRGGPPCKP-PAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAE 488
Query: 285 RHFRVAKSF---DAVLEALSRGEPVDLSCLPPPP---DQLPPDPPSPPSQPPTPATAPST 338
+ R+ + F D L+A P S PPP +LP P PP+ PTP T P
Sbjct: 489 KLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAPTPETEPEE 548
Query: 339 TEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAV 398
PP Q VAAA G + + +
Sbjct: 549 PAQAPP--------AQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPE 600
Query: 399 DVAELPVPPGFPPI-------QGLEATKPTQQSLVGVLETAMKLANQDEGPEDE------ 445
E+P PP PP+ G+ T+ +G + L + + + E
Sbjct: 601 PPEEVP-PPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQ 659
Query: 446 -EDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPP 483
+ + + Q PT P +PP + G+ P +APP
Sbjct: 660 QQHQWQQHQQGSAPPTPVPPSPP-QPVTLGAVPAPQAPP 697
Score = 42.0 bits (97), Expect = 0.003
Identities = 64/287 (22%), Positives = 92/287 (32%), Gaps = 48/287 (16%)
Query: 197 IGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGP 256
+GK PA Y P +P +P P +L P+ S + P P G
Sbjct: 1912 LGKLPAGGVLYPPPSFLYSPAFCPSPLPDTSLLQVRQDLPSPSDFYSTPLQPGG------ 1965
Query: 257 LAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPD 316
Q + + A+Q + D+ L ++ G LPP P
Sbjct: 1966 -------QSGFLPSGAPAQQM-----------LLPMVDSQLPVVNFGS------LPPAP- 2000
Query: 317 QLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKAR 376
PP PP P PA P + V PPP L + + +A
Sbjct: 2001 --PPAPPPLSLLPVGPALQPPSLAVRPPPAPATRVLPSPARPFPASLG---------RAE 2049
Query: 377 MHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEA-TKPTQQSLVGVLETAMKL 435
+H +K +QD + + PP GL + K T + GV T
Sbjct: 2050 LHPVELKPFQDYQKL--SSNLGGPGSSRTPPTGRSFSGLNSRLKATPSTYSGVFRTQRVD 2107
Query: 436 ANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAP 482
Q P D +PK P P+ PSR + + K P
Sbjct: 2108 LYQQASPPDALRWIPKPWERTGPP---PREGPSRRAEEPGSRGDKEP 2151
Score = 40.0 bits (92), Expect = 0.010
Identities = 66/301 (21%), Positives = 95/301 (31%), Gaps = 43/301 (14%)
Query: 303 GEPVDLSCLPPP---------PDQLPPDPPSPPSQPPTPATAP---------STTEVP-- 342
G P LPPP P PD PP +PP P S++E+
Sbjct: 404 GPPAPKPPLPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLA 463
Query: 343 -PPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVA 401
R E E+RM+ + AA K K K ++ +K A A + A A
Sbjct: 464 VERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPA 523
Query: 402 ---ELPVPPGFPPIQG----LEATKPTQQSLV------GVLETAMKLANQDEGPEDEEDE 448
ELP PP PP E +P Q GV ++
Sbjct: 524 VPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGS 583
Query: 449 VPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATS---TRAQQQLAFLEGRKKQLL 505
P P+ + PP P + P K PK TR + ++ L
Sbjct: 584 FEASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSL 643
Query: 506 QAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVNKDDFALVQRPG 565
+ +Q+ + L+Q + + + P + PP PV Q P
Sbjct: 644 PPRFQRQQQEQL------LKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPP 697
Query: 566 P 566
P
Sbjct: 698 P 698
Score = 36.6 bits (83), Expect = 0.11
Identities = 47/175 (26%), Positives = 56/175 (32%), Gaps = 17/175 (9%)
Query: 182 KGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATA---PAS 238
KG + +PPP P +Y P AP P R LE P P
Sbjct: 819 KGMRSETPPVPPP------PPYLASYPGFPENGAP---GPPISRFPLEEPGPRPLPWPPG 869
Query: 239 SPGLAKPQMPPGPCSPGP--LAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAV 296
S +AK Q PP P AQL + K A R R +
Sbjct: 870 SDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQGPPPPRRESRTETRWGPR 929
Query: 297 LEALSRGEPVDLSCLPPP---PDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTL 348
+ RG P + PP P + PP P PP P T PP P L
Sbjct: 930 PGSSRRGIPPEEPGAPPRRAGPIKKPPPPTKVEELPPKPLEQGDETPKPPKPDPL 984
>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
Length = 538
Score = 54.3 bits (129), Expect = 5e-07
Identities = 81/336 (24%), Positives = 116/336 (34%), Gaps = 54/336 (16%)
Query: 127 PKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAI 186
P+PE LE +Q+R A+ + + + + ++A+++ RG
Sbjct: 64 PEPERTRAELEKLIQQR-AVLRVSYKGSISYRNAARVQPPRRGA---------------- 106
Query: 187 DEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQ 246
PP A PA+ +P PT PAP P P A AP ++ A
Sbjct: 107 --TPPAPPRAPRGAPAAAAAAAPPPT-PAP----PPPPAPVAAAAPARAPRAAAAAATAP 159
Query: 247 MPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPV 306
PGP PGP AQ + A L A A A R P
Sbjct: 160 PSPGPAQPGPRAQ--------RAAPLAAPPPAPAAPPA----------VAPPAGPRRAPP 201
Query: 307 DLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEA--LEQRMERYQVAAA 364
PP PP PP+PP Q P P PPP + A + + +V
Sbjct: 202 PAVAAREPPLPPPPQPPAPPQQQQPPPPQPQ----PPPEGGAVRAGGAARPVSLREVVRY 257
Query: 365 QAKSKG-DQRKARMHERIVKQYQDAIRAHKAGRAVDVAELP---VPPGFPPIQGLEATKP 420
S G R R + + + + A R + LP P PP ++
Sbjct: 258 LGGSGGAGGRLTRGRVQGLLEEEAAARGRLERTRLGALALPRGDRPGRAPPAASARPSRS 317
Query: 421 TQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSP 456
+ VLE + D+ EDEED+V + P
Sbjct: 318 KRGGEERVLEKEEE--EDDDEDEDEEDDVSEGSEVP 351
Score = 47.8 bits (112), Expect = 5e-05
Identities = 47/182 (25%), Positives = 57/182 (31%), Gaps = 43/182 (23%)
Query: 312 PPPPDQLPPDPPSPPSQPPTPATA---PSTTEVPPPPRTLLEALEQRMERYQVAAAQAKS 368
PP PP PP P P A A P T PPPP + A R R AAA A
Sbjct: 101 PPRRGATPPAPPRAPRGAPAAAAAAAPPPTPAPPPPPAPVAAAAPARAPRAAAAAATAPP 160
Query: 369 KGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGV 428
+ +A RA +A P P PP A
Sbjct: 161 SPGPAQP---------------GPRAQRAAPLAAPPPAPAAPPAVAPPA----------- 194
Query: 429 LETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATST 488
GP + P+ P QP APP + Q P + PP+ +
Sbjct: 195 ------------GPRRAPPPAVAAREPPLPPPPQPPAPPQQ--QQPPPPQPQPPPEGGAV 240
Query: 489 RA 490
RA
Sbjct: 241 RA 242
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 53.9 bits (128), Expect = 7e-07
Identities = 88/372 (23%), Positives = 133/372 (35%), Gaps = 63/372 (16%)
Query: 6 GPPGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVGGQPPALEKLKGK 65
G PG PG+ ++ L L+P G GA + G+ E L G
Sbjct: 581 GSPGAPGKYLSSV--LASAPFLAPPGAGSYAAGAGGYK----------GKGDGSELLAGP 628
Query: 66 GPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASE---TPP 122
G P E E L T D +D A+ ++ LG A TP
Sbjct: 629 GGPPAERTEDEEFLIQHLLQAPSPPRTSGADGLVGEDGAADASKGLGGSGGAGGPPGTPY 688
Query: 123 PVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRY--DRGLKTLENLLASI 180
+A+ P+ H L++ ++ +L + A + K ++ +RG +T E L S+
Sbjct: 689 ELAKEDPQRYH--LQSVIRTSASLDEGATAALELGLGRLKEKKKGPERGGETPEGLATSV 746
Query: 181 -------RKGNAIDEADIPPPVAIGKGPASTP--------------TYSPAPTQPAPRIA 219
++ A + PPP + TP P P Q P +
Sbjct: 747 VHYGAGAKELGAFLQKSPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVL 806
Query: 220 S---APEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQ 276
S +P P + G PA+ G +P PP P P QL++ R + L
Sbjct: 807 SHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGL------- 859
Query: 277 QGDTTAAARHFRVAKSFD---AVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPA 333
+ A + R +S D A+ E L EP LPP P PP+ + P A
Sbjct: 860 --EPAAPSPRLRPEESLDPPGAMQELLGALEP-----LPPAPGDTGVGPPNSEGKDPAGA 912
Query: 334 ---TAPSTTEVP 342
+P T+ P
Sbjct: 913 YRSPSPQGTKAP 924
Score = 50.1 bits (118), Expect = 1e-05
Identities = 102/418 (24%), Positives = 135/418 (32%), Gaps = 130/418 (31%)
Query: 3 KRKGPPGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVGGQPPA--LE 60
KR GPP P RG R L + P P DGA + LE
Sbjct: 1163 KRDGPPRP--RGRPRIRPLEVPTTAGPASASTPTDGAKKPRGRGRGRGRKAEEAGGTRLE 1220
Query: 61 KLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEAD---DDLLAELNEVLGEEQKA 117
LK PL ++ A + D GTD + L++ + + A++ EV E+K
Sbjct: 1221 PLK---PLKIKLSVPKAGEGLGTSSGDAISGTDHNSLDSSLTREKIEAKIKEV---EEKQ 1274
Query: 118 SETP--------------------------PPVAQPK---PEAPHPGLETTLQERLALYQ 148
E PP++ PK P P GL+ A+
Sbjct: 1275 PEMKSGFMASFLDFLKSGKRHPPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPH 1334
Query: 149 T----------AIESARQAGDS----AKMRRYDRGLK-TLENLLA-------SIRKG--- 183
A+E+A G + +R D LK LE L + S+ K
Sbjct: 1335 PPPSGAFGLGGALEAAESEGLGLGCPSPCKRLDEELKRNLETLPSFSSDEEDSVAKNRDL 1394
Query: 184 -----NAIDEADIPP-----PVAIGKGP-----ASTPTYSPAPTQPAPRIASAPEPRVTL 228
+AI D PP + GP A+ P P P P+ PEP +
Sbjct: 1395 QESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLE 1454
Query: 229 EGPSATAP-ASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHF 287
E P T P A +P +PQ PP P P P
Sbjct: 1455 EKPPPTPPPAPTP---QPQPPPPPPPPQP------------------------------- 1480
Query: 288 RVAKSFDAVLEALSRGEPV--DLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPP 343
AL P+ PPPP PP PP+ PS PP P A + PP
Sbjct: 1481 -----------ALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPP 1527
Score = 47.8 bits (112), Expect = 5e-05
Identities = 73/323 (22%), Positives = 117/323 (36%), Gaps = 21/323 (6%)
Query: 57 PALEKLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLL-AELNEVLGEEQ 115
P +L PL + ++ A++C +E E G + E D+ ++ AE L
Sbjct: 1535 PEDPELPDTRPLHLAKKQETAAVCGETDEEAGESGGEGIFRERDEFVIRAEDIPSLKLAL 1594
Query: 116 KASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLEN 175
+ PPP+ + + +A +++ + GD AK R +K LEN
Sbjct: 1595 QTGREPPPIWRVQ-KALLQKFTPEIKDGQRQFCATSNYLGYFGD-AKNRYQRLYVKFLEN 1652
Query: 176 LLASIRKGNAIDEADIPPPVAIGK-GPASTPTYSPAPTQPAPRI-ASAPEPRVTLEGPSA 233
+ + PPV + + G A P + + P P+ A P+P + S
Sbjct: 1653 VNKKDYVRVCARKPWHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSE 1712
Query: 234 TAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSF 293
P +P A P+ PP P P L ++ + K+ +G+ + R R +S
Sbjct: 1713 KPPEQTPETAMPE-PPAPEKPSLLRPVEKEKEKEKVTRGERPLRGERATSGRQTRPERSL 1771
Query: 294 DAVLEALSR---GEPVDLSCLPPPPDQ------------LPPDPPSPPSQPPTPATAPST 338
A SR P + PPP + PP S + APS
Sbjct: 1772 ATGQPATSRLPKARPTKVKAEPPPKKRKKWLKEAGGNATAGGGPPGSSSDSESSPGAPSE 1831
Query: 339 TEVPPPPRTLLEALEQRMERYQV 361
E P R L + M R V
Sbjct: 1832 DERAVPGRLLKTRAMREMYRSYV 1854
Score = 40.0 bits (92), Expect = 0.010
Identities = 56/227 (24%), Positives = 80/227 (35%), Gaps = 48/227 (21%)
Query: 292 SFDAVLEALSRGEPVDLSCLPPP---PDQLPPDPPSPPSQPPTPATAPSTTEVPP----- 343
SF L++ R P+ + L PP P +PP P+ QP PAT P+ PP
Sbjct: 1284 SFLDFLKSGKRHPPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPAT-PAVPHPPPSGAFG 1342
Query: 344 -------------------PPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQ 384
P + L E L++ +E + S ++ + + +
Sbjct: 1343 LGGALEAAESEGLGLGCPSPCKRLDEELKRNLE-----TLPSFSSDEEDSVAKNRDLQES 1397
Query: 385 YQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPED 444
AI A + P G PP+ A P L G + AN + PE
Sbjct: 1398 ISSAISALDDPPLAGPKDTSTPDG-PPLAPAAAV-PGPPPLPG-----LPSANSNGTPEP 1450
Query: 445 EEDEVPKKQNSPVAPTAQPKAPPSRTPQSGS--------APTAKAPP 483
E P APT QP+ PP P + APT +PP
Sbjct: 1451 PLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPP 1497
Score = 38.9 bits (89), Expect = 0.023
Identities = 20/65 (30%), Positives = 26/65 (40%)
Query: 192 PPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGP 251
PPP P+ P +P P+ P P P P P PA++P A P+ P P
Sbjct: 1474 PPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAP 1533
Query: 252 CSPGP 256
P
Sbjct: 1534 SPEDP 1538
Score = 37.4 bits (85), Expect = 0.067
Identities = 43/151 (28%), Positives = 51/151 (33%), Gaps = 7/151 (4%)
Query: 198 GKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPA---SSPGLAK-PQMPPGPCS 253
G GPA TP Y P P P P P L SA A A SSP L PGP
Sbjct: 218 GLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGP-- 275
Query: 254 PGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPP 313
P P L + K A Q H + S G +L+C P
Sbjct: 276 PPPERALPRQDTVIKHYQRPASAQPPPPPPPAH-ALQHYLSCGGSYPSMGHRANLACSPL 334
Query: 314 PPDQLPPDPPSPPSQPPTPATAPSTTEVPPP 344
+ P P P+ ATA ++ P
Sbjct: 335 GGGEPSPGAGEPSKAGPSGATAGASGRATGP 365
Score = 35.8 bits (81), Expect = 0.20
Identities = 41/191 (21%), Positives = 64/191 (33%), Gaps = 20/191 (10%)
Query: 297 LEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPP-----PPRTLLEA 351
L + EP+ L + P Q P PP PP PP PA+ P P P+ LL+
Sbjct: 1018 LPSTVNAEPLGL--IQSGPHQAAPPPPPPPPPPPAPASEPKGGLTSPIFCSTKPKKLLKT 1075
Query: 352 LEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPP 411
+ R + Q K ++Y+ KA D+ P P
Sbjct: 1076 SSFHLLRRRDPPFQTPKK----------LYAQEYEFEADEDKADVPADIR--LNPRRLPD 1123
Query: 412 IQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTP 471
+ ++P L G ++ D K++ P P +P+ P P
Sbjct: 1124 LVSSCRSRPALSPL-GDIDFCPPNPGPDGPRRRGRKPTKAKRDGPPRPRGRPRIRPLEVP 1182
Query: 472 QSGSAPTAKAP 482
+ +A P
Sbjct: 1183 TTAGPASASTP 1193
Score = 35.0 bits (79), Expect = 0.33
Identities = 26/103 (25%), Positives = 35/103 (33%), Gaps = 13/103 (12%)
Query: 315 PDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRM-ERYQVAAAQAKSKGDQR 373
P Q PP P PP PP P P+ + A EQ + Y + A +R
Sbjct: 221 PAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPPPPER 280
Query: 374 KARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLE 416
+ ++K YQ A PP PP L+
Sbjct: 281 ALPRQDTVIKHYQRPASAQP------------PPPPPPAHALQ 311
Score = 33.1 bits (74), Expect = 1.3
Identities = 20/59 (33%), Positives = 24/59 (40%), Gaps = 2/59 (3%)
Query: 193 PPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGP 251
PP + P+S P P P P P + S P P P A AP P P+ P P
Sbjct: 1485 PPPLVAPTPSSPPP-PPLPPPPPPAMPSPPPPPPPAAAPLA-APPEEPAAPSPEDPELP 1541
Score = 30.8 bits (68), Expect = 6.3
Identities = 22/57 (38%), Positives = 24/57 (42%), Gaps = 11/57 (19%)
Query: 300 LSRGEPVDLSCLPPPPDQLPPDPPS-PPSQPPT----------PATAPSTTEVPPPP 345
L G P LPPPP QL P S PS P+ PAT + PPPP
Sbjct: 783 LEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPP 839
>gi|148277037 AP2 associated kinase 1 [Homo sapiens]
Length = 961
Score = 53.5 bits (127), Expect = 9e-07
Identities = 68/298 (22%), Positives = 101/298 (33%), Gaps = 35/298 (11%)
Query: 205 PTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQ 264
P P P + + A +P+ L P T S +P+ +PG L +Q
Sbjct: 330 PAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILP-IQPAL 388
Query: 265 RDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPS 324
K A + Q A S +P L+ +P P Q PP P
Sbjct: 389 TPRKRATVQPPPQA--------------------AGSSNQPGLLASVPQPKPQAPPSQPL 428
Query: 325 P------PSQPPTPATAPSTTE--VPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKAR 376
P P PPTP PST +P + + +Q + Q Q Q
Sbjct: 429 PQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGT 488
Query: 377 MHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLA 436
+++ Q Q H A + +A+ PV Q L QQ + +LA
Sbjct: 489 FYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLA 548
Query: 437 NQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSA--PTAKAP----PKATST 488
+ + +Q +A QP+ P+ PQ A P +AP PK +T
Sbjct: 549 TALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTT 606
Score = 31.2 bits (69), Expect = 4.8
Identities = 42/209 (20%), Positives = 74/209 (35%), Gaps = 45/209 (21%)
Query: 67 PLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPPPVAQ 126
PLP + A P + T L A + + L +Q+ + PP AQ
Sbjct: 427 PLP----QTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQ 482
Query: 127 PKP---------------EAPHPGLETTLQERLALY---------QTAIESARQAGDSAK 162
+P +A HP T Q +A + Q +++ Q +
Sbjct: 483 QQPAGTFYQQQQAQTQQFQAVHPA---TQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQ 539
Query: 163 MRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSP-----------AP 211
++ + L T + + + A+ + P +A G+ P P +P AP
Sbjct: 540 QQQQQQQLATALHQQQLMTQQAALQQK---PTMAAGQQPQPQPAAAPQPAPAQEPAIQAP 596
Query: 212 TQPAPRIASAPEPRVTLEGPSATAPASSP 240
+ P++ + P P V + + P SSP
Sbjct: 597 VRQQPKVQTTPPPAVQGQKVGSLTPPSSP 625
>gi|150417989 cyclin K isoform 1 [Homo sapiens]
Length = 580
Score = 53.5 bits (127), Expect = 9e-07
Identities = 67/271 (24%), Positives = 97/271 (35%), Gaps = 54/271 (19%)
Query: 112 GEEQKASETP-----PPVAQPKPEAPH-------------PGLETTLQERLALYQTAIES 153
G++Q TP PP QP P+ P + Q+ Q A +
Sbjct: 261 GKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQP 320
Query: 154 ARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPA--- 210
+ + + R+ R + + S ++ N E PPP I K + P PA
Sbjct: 321 KKPSPQPSSPRQVKRAV------VVSPKEENKAAE---PPPPKIPKIETTHPPLPPAHPP 371
Query: 211 PTQPAPRIASAPE------------PRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLA 258
P + P A+ E P+V + P+ AP P P +P P P P
Sbjct: 372 PDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQP----PPLPHRPPPPPP-- 425
Query: 259 QLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPP--PPD 316
S + + +G + + S+ A+ A G P L P PP+
Sbjct: 426 --SSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAY--GPPAHLPYHPHVYPPN 481
Query: 317 QLPPDPPSPPSQPPTPATAPSTTEVPPPPRT 347
PP P PP+ P PA P T PPPP T
Sbjct: 482 PPPPPVPPPPASFPPPAIPPPTPGYPPPPPT 512
Score = 33.5 bits (75), Expect = 0.97
Identities = 24/67 (35%), Positives = 27/67 (40%), Gaps = 8/67 (11%)
Query: 191 IPPPVAIGKGPASTPTYSPAPTQPAPRIASA------PEPRVTLEGPSATAPASSPGLAK 244
IPPP P PTY+P P PR+ P P + L S PA PG
Sbjct: 499 IPPPTP--GYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQP 556
Query: 245 PQMPPGP 251
P PP P
Sbjct: 557 PVPPPIP 563
Score = 33.5 bits (75), Expect = 0.97
Identities = 18/44 (40%), Positives = 20/44 (45%), Gaps = 10/44 (22%)
Query: 312 PPPPDQLPPD-------PPS---PPSQPPTPATAPSTTEVPPPP 345
PPPP +LPP PP PP+ P PA P PPP
Sbjct: 518 PPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPP 561
Score = 32.3 bits (72), Expect = 2.2
Identities = 25/70 (35%), Positives = 26/70 (37%), Gaps = 8/70 (11%)
Query: 191 IPPPVAIGKGPA---STPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKP-- 245
+PPP A PA TP Y P P P P P L A P PGL P
Sbjct: 487 VPPPPASFPPPAIPPPTPGYPPPPPTYNPNF---PPPPPRLPPTHAVPPHPPPGLGLPPA 543
Query: 246 QMPPGPCSPG 255
PP PG
Sbjct: 544 SYPPPAVPPG 553
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 53.5 bits (127), Expect = 9e-07
Identities = 84/383 (21%), Positives = 137/383 (35%), Gaps = 71/383 (18%)
Query: 201 PASTPTYSPAPT--QPAPRIASAPE-PRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPL 257
PAS A T + +P+ + P P + P++ P+ PG P PP P G
Sbjct: 444 PASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSP--RGTT 501
Query: 258 AQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQ 317
A + R R + A G + R + ++ A P P P
Sbjct: 502 ASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPA------PSPTP 555
Query: 318 LPPDPPSPPSQPPTPATAPSTTEVPPPPRT---LLEALEQRMERYQVAAAQAKSKGDQRK 374
PP PP++ PT A ++ P PP T + R E ++ A + + +QR+
Sbjct: 556 APPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQRE 615
Query: 375 ARMHERIVKQYQD-AIRAHKAGRAVDV-AELPVPPGFPPIQGLEATKPTQQSLVGVLETA 432
ER ++ +D +R + R + AE + EA + +Q
Sbjct: 616 REEQERRLQAERDKRMREEQLAREAEARAE----------REAEARRREEQE-------- 657
Query: 433 MKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQ 492
A + E EE E +KQ ++ +A R + QQ
Sbjct: 658 ---AREKAQAEQEEQERLQKQKEEAEARSREEAERQRLER--------------EKHFQQ 700
Query: 493 QLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVPPAP 552
Q + R+K+L + R + K + + K + EA+ NG P P
Sbjct: 701 QEQERQERRKRLEEIMKRTR--------KSEVSETKQKQDSKEANANG-------SSPEP 745
Query: 553 VNKDDFALVQRPGPGLSQEAARR 575
V V+ PGL +EA ++
Sbjct: 746 VK-----AVEARSPGLQKEAVQK 763
Score = 42.0 bits (97), Expect = 0.003
Identities = 73/334 (21%), Positives = 116/334 (34%), Gaps = 40/334 (11%)
Query: 192 PPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPR-VTLEGPSATAPASSPGLAKPQMPPG 250
P + K AS S AP PAP A +P P E P A P + L P P
Sbjct: 523 PEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAP 582
Query: 251 PCSPG-PLAQLQSRQRDYKLAA---LHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPV 306
P +P P+A R+ +L A A++Q + R + + E L+R
Sbjct: 583 PVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEA 642
Query: 307 DLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQA 366
+ + + R+ EA QR+ER + Q
Sbjct: 643 RAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQE 702
Query: 367 KSKGDQRKARMHERI----------VKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLE 416
+ + ++RK R+ E + KQ QD+ A+ G + + P++ +E
Sbjct: 703 QERQERRK-RLEEIMKRTRKSEVSETKQKQDSKEANANGSSPE-----------PVKAVE 750
Query: 417 ATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSA 476
A P Q K A Q E P +E + A P ++G +
Sbjct: 751 ARSPGLQ----------KEAVQKEEPIPQEPQWSLPSKELPASLVNGLQPLPAHQENGFS 800
Query: 477 PTAKAPPKATSTRAQQQLAFLEGR---KKQLLQA 507
+ K+ S + L F E KK ++Q+
Sbjct: 801 TNGPSGDKSLSRTPETLLPFAEAEAFLKKAVVQS 834
Score = 38.1 bits (87), Expect = 0.039
Identities = 76/376 (20%), Positives = 134/376 (35%), Gaps = 64/376 (17%)
Query: 196 AIGKGPASTPTYSPAPTQPAPRIASAPE--PRVTLEGPSATAPASSPGLAKPQMPPGPCS 253
++ +GP T+ A PR ASA P APA G + + P S
Sbjct: 342 SLARGPQPDRTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERG--ERRKPNAGGS 399
Query: 254 PGPLAQ------LQSRQRDYK----------LAALHAKQQGDTTAAARHFRVAKSFDAVL 297
P P+ + +Q +++ K LA + ++ + A+ R++ S + L
Sbjct: 400 PAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASEL 459
Query: 298 EALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRME 357
S+ P S P P P + PP P + TT P + R+
Sbjct: 460 SPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASP----------KGRVR 509
Query: 358 RYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAH-------------------KAGRAV 398
R + A + G + K++ R + + A A A
Sbjct: 510 RKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPT 569
Query: 399 DVAELPVPPG-FPPIQGLEATKPT--QQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNS 455
D A L PP PP+ + T ++ +L + A + E++E + +++
Sbjct: 570 DAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDK 629
Query: 456 PVAPTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKN 515
+ R Q A+A +A + R ++Q A + + +Q Q L+ KQK
Sbjct: 630 RM-----------REEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQ-KQKE 677
Query: 516 DVEGAKMHLRQAKGLE 531
+ E + + LE
Sbjct: 678 EAEARSREEAERQRLE 693
Score = 33.9 bits (76), Expect = 0.74
Identities = 47/227 (20%), Positives = 81/227 (35%), Gaps = 36/227 (15%)
Query: 305 PVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAA 364
P ++ PP P P PSPP PP A P T PP + ++
Sbjct: 15 PAVVARTPPEPRPSPEGDPSPPP-PPMSALVPDTPPDTPPAM-----------KNATSSK 62
Query: 365 QAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQS 424
Q + + ++ R +++ + R P PP P + +Q S
Sbjct: 63 QLPLEPESPSGQVGPRPAPPQEESPSSEAKSRG------PTPPAMGPRDARPPRRSSQPS 116
Query: 425 LVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPK 484
V + Q+ E ++ K++ A K A + K
Sbjct: 117 PTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAK----------KAVWLEKEEK 166
Query: 485 ATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLE 531
A + R +Q L+ R+++L + L+A+Q+ A + RQ + LE
Sbjct: 167 AKALREKQ----LQERRRRLEEQRLKAEQRR----AALEERQRQKLE 205
Score = 31.2 bits (69), Expect = 4.8
Identities = 28/117 (23%), Positives = 49/117 (41%), Gaps = 13/117 (11%)
Query: 811 PVPAAVPTQVAGPKGKAPPVPAPARESGNRSARPLHSLSVLAFDQERLERKILALRQARR 870
P ++ P+ A P +PP +++G R LA ++ K LA ++A
Sbjct: 109 PRRSSQPSPTAVPASDSPPTKQEVKKAGERHK--------LAKERREERAKYLAAKKAVW 160
Query: 871 PVPPEVA-----QQYQDIMQRSQWQRAQLEQGGVGIRREYAAQLERQLQFYTEAARR 922
E A +Q Q+ +R + QR + EQ + +LE+ + Y A +R
Sbjct: 161 LEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQR 217
>gi|55749531 splicing factor 3B subunit 2 [Homo sapiens]
Length = 895
Score = 53.1 bits (126), Expect = 1e-06
Identities = 55/203 (27%), Positives = 85/203 (41%), Gaps = 34/203 (16%)
Query: 240 PGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVL-- 297
P A+ Q+PP P PG +++ KLA + A QG+ + ++
Sbjct: 8 PPKAELQLPPPP-PPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLN 66
Query: 298 EALSRGEPVDLSC------------LPPPPDQLPPDPPSPPSQPPTPA------TAPSTT 339
+ RGE D + +PPPP LPP P PP PP P A
Sbjct: 67 RPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPN 126
Query: 340 EVPPPPRTLLEAL----EQRMERYQVAAA-------QAKSKGDQRKARMHERIVKQYQDA 388
PPPP + E + E+R++ Q AA +AK +GD + HE + +Q + A
Sbjct: 127 LGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGD-HSLKEHELLEQQKRAA 185
Query: 389 IRAHKAGRAVDVAELPVPPGFPP 411
+ + R ++A++ P PP
Sbjct: 186 VLLEQE-RQQEIAKMGTPVPRPP 207
Score = 35.8 bits (81), Expect = 0.20
Identities = 73/306 (23%), Positives = 101/306 (33%), Gaps = 62/306 (20%)
Query: 121 PPPVAQPKPEAPHPG-----LETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLEN 175
PP P P PG LQ +LA I+ R+ +++ Y R + N
Sbjct: 8 PPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVE-RLQSYTRQTGIVLN 66
Query: 176 LLASIRKGNAIDEADIPPPVAIGKG-PASTPTYSPAPTQPAPRIASAPEPRVTLEGPSAT 234
+ +G D+A PP A G P P P QP P P P + L P A
Sbjct: 67 --RPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPP-PPPPPPGLGLGFPMAH 123
Query: 235 APASSPGLAKPQMPPGPCSPGPLAQLQSRQR---DYKLAAL------HAKQQGDTTAAAR 285
P P P P G L +R + AAL AKQQGD +
Sbjct: 124 PPNLGP--------PPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEH 175
Query: 286 HFRVAKSFDAVL-------EALSRGEPVD----------------------LSCLPPPPD 316
+ AVL E G PV + + P P
Sbjct: 176 ELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPT 235
Query: 317 QLPPDPPSPPSQPPTPATAPSTTEVPPP------PRTLLEALEQRMERYQVAAAQAKSKG 370
LP P P + P P E+ P P+ L + L+ + R + +Q + +
Sbjct: 236 VLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEE 295
Query: 371 DQRKAR 376
+ AR
Sbjct: 296 METDAR 301
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 52.8 bits (125), Expect = 2e-06
Identities = 86/385 (22%), Positives = 119/385 (30%), Gaps = 49/385 (12%)
Query: 120 TPPPVAQPKPEAPHPGL----ETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLE- 174
T P + KP P P L +T+ + L + + ++ + K D KT
Sbjct: 114 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 173
Query: 175 NLLASIRKGNAIDEADI------PPPVA--IGKGPASTPTYSPAPTQPAPRIASAP-EPR 225
SI K +A D A P P A KGPA T P PT P ++ P EP
Sbjct: 174 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 233
Query: 226 VTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAAR 285
T + T P P P P P + A K+ TT
Sbjct: 234 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP-------APTTPKEPAPTTT--- 283
Query: 286 HFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPP 345
P P P + P P P+ P TP TT P P
Sbjct: 284 ---------------KEPAPTTTKSAPTTPKEPAPTTPKKPA-PTTPKEPAPTTPKEPTP 327
Query: 346 RTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAE-LP 404
T E E + ++ A + + A K E P
Sbjct: 328 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPK-----EPAPTTPKEPAPTTTKEPSP 382
Query: 405 VPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPK 464
P P ++ T + + ++ P ++ P P APT PK
Sbjct: 383 TTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP-APTT-PK 440
Query: 465 APPSRTPQSGSAPTAKAPPKATSTR 489
P TP+ APT P T+T+
Sbjct: 441 KPAPTTPKE-PAPTTPKEPAPTTTK 464
Score = 48.5 bits (114), Expect = 3e-05
Identities = 68/319 (21%), Positives = 94/319 (29%), Gaps = 33/319 (10%)
Query: 192 PPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGP 251
P P P +T +P T+ AP P P T E T +P K P P
Sbjct: 388 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 447
Query: 252 CSPGPLAQLQ-SRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVL-EALSRGEPVDLS 309
P P + + K A K+ TT K E L+ P +
Sbjct: 448 KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 507
Query: 310 CLPPPPDQLPPDPPSPPS-------QPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVA 362
P P++L P P P+ P TP A T P P T E + + A
Sbjct: 508 --PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPK--EPA 563
Query: 363 AAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEAT---- 418
K +K+ A + P P P E T
Sbjct: 564 PTTPKETAPTTPKGTAPTTLKE-----------PAPTTPKKPAPKELAPTTTKEPTSTTC 612
Query: 419 -KPTQQSLVGVLETAMK----LANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQS 473
KP + G T K ++ P + P P T + AP P +
Sbjct: 613 DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 672
Query: 474 GSAPTAKAPPKATSTRAQQ 492
PT+ K T ++
Sbjct: 673 TKGPTSTTSDKPAPTTPKE 691
Score = 46.2 bits (108), Expect = 1e-04
Identities = 73/359 (20%), Positives = 112/359 (31%), Gaps = 38/359 (10%)
Query: 199 KGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLA 258
KG A T PAPT P P T E S T +P K P P P P
Sbjct: 576 KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 635
Query: 259 QLQSRQRDYK-LAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPP--P 315
+ K A K+ TT + + ++G S P P P
Sbjct: 636 PKEPAPTTPKGTAPTTLKEPAPTTPK------KPAPKELAPTTTKGPTSTTSDKPAPTTP 689
Query: 316 DQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKA 375
+ P P P+ AP+T E PPP + + E + + +S +
Sbjct: 690 KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE---- 745
Query: 376 RMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKL 435
+ A +A++ P PG P + ATKP + T L
Sbjct: 746 -------------LSAEPTPKALE--NSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDL 790
Query: 436 ANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLA 495
E ++ K+ + T + K + T + + P K T+ +
Sbjct: 791 RTTPE-TTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAP 849
Query: 496 FLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVN 554
+ KK + + K + + K +K P P TK P P +
Sbjct: 850 KVTTTKKTITTTEIMNKPEETAK-PKDRATNSKATTPK--------PQKPTKAPKKPTS 899
Score = 45.4 bits (106), Expect = 2e-04
Identities = 73/299 (24%), Positives = 98/299 (32%), Gaps = 29/299 (9%)
Query: 202 ASTPTYSPAPTQP---APRIASAPEPRVTLEGPSATAP-ASSPGLAKPQMPPGPCSPGPL 257
A T PAPT P AP P P T E P+ T P A++P K P P P P
Sbjct: 499 APTTPEKPAPTTPEELAPTTPEEPTP-TTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT 557
Query: 258 AQLQSRQRDYK-LAALHAKQQGDTT-AAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPP 315
+ K A K TT K L + EP +C P P
Sbjct: 558 TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 617
Query: 316 DQLPPDPPSPPSQ--PPTPATAPSTTEVPPPPRTLLE---ALEQRMERYQVAAAQAKSKG 370
P+ P + P TP TT P TL E ++ ++A K
Sbjct: 618 TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 677
Query: 371 DQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLE 430
+ K+ A P P PP E + PT
Sbjct: 678 STTSDKPAPTTPKETAPTTPKEPA-PTTPKKPAPTTPETPPPTTSEVSTPTTTK----EP 732
Query: 431 TAMKLANQDEGPEDEEDEVPKK-QNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATST 488
T + + + PE + PK +NSP +P P ++TP A P+ T+T
Sbjct: 733 TTIHKSPDESTPELSAEPTPKALENSP----KEPGVPTTKTP-------AATKPEMTTT 780
Score = 43.5 bits (101), Expect = 0.001
Identities = 65/309 (21%), Positives = 92/309 (29%), Gaps = 31/309 (10%)
Query: 193 PPVAIGKGPASTPTYSPAPT--QPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPG 250
P K P T PAPT +PAP P P + T +P K P
Sbjct: 317 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 376
Query: 251 PCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSC 310
P P + K A K+ TT + + + + P +
Sbjct: 377 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKE--- 433
Query: 311 LPPPPDQLPPDPPSPPSQPPT--PATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKS 368
P P P P +P PT AP+TT+ P P A E +
Sbjct: 434 -PAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 492
Query: 369 KGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGV 428
++ A K P P P E PT
Sbjct: 493 TTPEKLA------------PTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTP----- 535
Query: 429 LETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATST 488
+ A ++ P ++ P P T + AP T G+APT P T+
Sbjct: 536 -KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAP---TTPKGTAPTTLKEPAPTTP 591
Query: 489 R--AQQQLA 495
+ A ++LA
Sbjct: 592 KKPAPKELA 600
Score = 42.4 bits (98), Expect = 0.002
Identities = 68/307 (22%), Positives = 90/307 (29%), Gaps = 32/307 (10%)
Query: 193 PPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPC 252
P KG A T PAPT P P T S T+ +P K P P
Sbjct: 639 PAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 698
Query: 253 SPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLP 312
P P + + + T + KS D LS EP P
Sbjct: 699 EPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELS-AEPT-----P 752
Query: 313 PPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQ 372
+ P +P P ++ P AT P T T + +R R A K +
Sbjct: 753 KALENSPKEPGVPTTKTPA-ATKPEMT------TTAKDKTTERDLRTTPETTTAAPKMTK 805
Query: 373 RKARMHERIVKQYQDAIRAHKAGRAVD------VAELPVPPGFPPIQGLEATKPTQQSLV 426
A E+ + A + L P + + T T + +
Sbjct: 806 ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMN 865
Query: 427 GVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAP-----PSRTPQSGSAPTAKA 481
ETA P+D P PT PK P P P+ T
Sbjct: 866 KPEETAK--------PKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPT 917
Query: 482 PPKATST 488
P K TST
Sbjct: 918 PRKMTST 924
Score = 39.7 bits (91), Expect = 0.014
Identities = 74/358 (20%), Positives = 116/358 (32%), Gaps = 30/358 (8%)
Query: 150 AIESARQAGDSAKMRRYDRGLKTLENLLASIR--KGNAIDEADIPPPVAI---GKG---- 200
+ E R+ A+ ++YD+ E+ A ++ K N + P P + G G
Sbjct: 36 SFERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 95
Query: 201 -------PASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCS 253
ST ++ T P A PR +L S T+ +S + K +
Sbjct: 96 DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKET 155
Query: 254 PGPLAQLQSRQRDYKLAALHAKQQGDTTAA--ARHFRVAKSFDAVLEALSRGEPVDLSCL 311
Q + ++ +A + T+A A +V E ++G +
Sbjct: 156 TTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE 215
Query: 312 PPPPDQLPPDPPSPPSQPPTPATAPS--TTEVPPPPRTLLEALEQRMERYQVAAAQAKSK 369
P P P +P S + PTP T S TT P P T A E +
Sbjct: 216 PTPTT--PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPT 273
Query: 370 GDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFP-PIQGLEATKPTQQSLVGV 428
+ A + + A K+ P P P P E T +
Sbjct: 274 TPKEPAPTTTK-----EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPT 328
Query: 429 LETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKAT 486
++ P ++ P P APT PK P TP+ + T K P T
Sbjct: 329 TPKEPAPTTKEPAPTTPKEPAPTAPKKP-APTT-PKEPAPTTPKEPAPTTTKEPSPTT 384
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 52.8 bits (125), Expect = 2e-06
Identities = 86/385 (22%), Positives = 119/385 (30%), Gaps = 49/385 (12%)
Query: 120 TPPPVAQPKPEAPHPGL----ETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLE- 174
T P + KP P P L +T+ + L + + ++ + K D KT
Sbjct: 155 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 214
Query: 175 NLLASIRKGNAIDEADI------PPPVA--IGKGPASTPTYSPAPTQPAPRIASAP-EPR 225
SI K +A D A P P A KGPA T P PT P ++ P EP
Sbjct: 215 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 274
Query: 226 VTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAAR 285
T + T P P P P P + A K+ TT
Sbjct: 275 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP-------APTTPKEPAPTTT--- 324
Query: 286 HFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPP 345
P P P + P P P+ P TP TT P P
Sbjct: 325 ---------------KEPAPTTTKSAPTTPKEPAPTTPKKPA-PTTPKEPAPTTPKEPTP 368
Query: 346 RTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAE-LP 404
T E E + ++ A + + A K E P
Sbjct: 369 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPK-----EPAPTTPKEPAPTTTKEPSP 423
Query: 405 VPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPK 464
P P ++ T + + ++ P ++ P P APT PK
Sbjct: 424 TTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP-APTT-PK 481
Query: 465 APPSRTPQSGSAPTAKAPPKATSTR 489
P TP+ APT P T+T+
Sbjct: 482 KPAPTTPKE-PAPTTPKEPAPTTTK 505
Score = 48.5 bits (114), Expect = 3e-05
Identities = 68/319 (21%), Positives = 94/319 (29%), Gaps = 33/319 (10%)
Query: 192 PPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGP 251
P P P +T +P T+ AP P P T E T +P K P P
Sbjct: 429 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 488
Query: 252 CSPGPLAQLQ-SRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVL-EALSRGEPVDLS 309
P P + + K A K+ TT K E L+ P +
Sbjct: 489 KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 548
Query: 310 CLPPPPDQLPPDPPSPPS-------QPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVA 362
P P++L P P P+ P TP A T P P T E + + A
Sbjct: 549 --PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPK--EPA 604
Query: 363 AAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEAT---- 418
K +K+ A + P P P E T
Sbjct: 605 PTTPKETAPTTPKGTAPTTLKE-----------PAPTTPKKPAPKELAPTTTKEPTSTTC 653
Query: 419 -KPTQQSLVGVLETAMK----LANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQS 473
KP + G T K ++ P + P P T + AP P +
Sbjct: 654 DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 713
Query: 474 GSAPTAKAPPKATSTRAQQ 492
PT+ K T ++
Sbjct: 714 TKGPTSTTSDKPAPTTPKE 732
Score = 46.2 bits (108), Expect = 1e-04
Identities = 73/359 (20%), Positives = 112/359 (31%), Gaps = 38/359 (10%)
Query: 199 KGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLA 258
KG A T PAPT P P T E S T +P K P P P P
Sbjct: 617 KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 676
Query: 259 QLQSRQRDYK-LAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPP--P 315
+ K A K+ TT + + ++G S P P P
Sbjct: 677 PKEPAPTTPKGTAPTTLKEPAPTTPK------KPAPKELAPTTTKGPTSTTSDKPAPTTP 730
Query: 316 DQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKA 375
+ P P P+ AP+T E PPP + + E + + +S +
Sbjct: 731 KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE---- 786
Query: 376 RMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKL 435
+ A +A++ P PG P + ATKP + T L
Sbjct: 787 -------------LSAEPTPKALE--NSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDL 831
Query: 436 ANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLA 495
E ++ K+ + T + K + T + + P K T+ +
Sbjct: 832 RTTPE-TTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAP 890
Query: 496 FLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVN 554
+ KK + + K + + K +K P P TK P P +
Sbjct: 891 KVTTTKKTITTTEIMNKPEETAK-PKDRATNSKATTPK--------PQKPTKAPKKPTS 940
Score = 45.4 bits (106), Expect = 2e-04
Identities = 73/299 (24%), Positives = 98/299 (32%), Gaps = 29/299 (9%)
Query: 202 ASTPTYSPAPTQP---APRIASAPEPRVTLEGPSATAP-ASSPGLAKPQMPPGPCSPGPL 257
A T PAPT P AP P P T E P+ T P A++P K P P P P
Sbjct: 540 APTTPEKPAPTTPEELAPTTPEEPTP-TTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT 598
Query: 258 AQLQSRQRDYK-LAALHAKQQGDTT-AAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPP 315
+ K A K TT K L + EP +C P P
Sbjct: 599 TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 658
Query: 316 DQLPPDPPSPPSQ--PPTPATAPSTTEVPPPPRTLLE---ALEQRMERYQVAAAQAKSKG 370
P+ P + P TP TT P TL E ++ ++A K
Sbjct: 659 TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 718
Query: 371 DQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLE 430
+ K+ A P P PP E + PT
Sbjct: 719 STTSDKPAPTTPKETAPTTPKEPA-PTTPKKPAPTTPETPPPTTSEVSTPTTTK----EP 773
Query: 431 TAMKLANQDEGPEDEEDEVPKK-QNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATST 488
T + + + PE + PK +NSP +P P ++TP A P+ T+T
Sbjct: 774 TTIHKSPDESTPELSAEPTPKALENSP----KEPGVPTTKTP-------AATKPEMTTT 821
Score = 43.5 bits (101), Expect = 0.001
Identities = 65/309 (21%), Positives = 92/309 (29%), Gaps = 31/309 (10%)
Query: 193 PPVAIGKGPASTPTYSPAPT--QPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPG 250
P K P T PAPT +PAP P P + T +P K P
Sbjct: 358 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 417
Query: 251 PCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSC 310
P P + K A K+ TT + + + + P +
Sbjct: 418 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKE--- 474
Query: 311 LPPPPDQLPPDPPSPPSQPPT--PATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKS 368
P P P P +P PT AP+TT+ P P A E +
Sbjct: 475 -PAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 533
Query: 369 KGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGV 428
++ A K P P P E PT
Sbjct: 534 TTPEKLA------------PTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTP----- 576
Query: 429 LETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATST 488
+ A ++ P ++ P P T + AP T G+APT P T+
Sbjct: 577 -KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAP---TTPKGTAPTTLKEPAPTTP 632
Query: 489 R--AQQQLA 495
+ A ++LA
Sbjct: 633 KKPAPKELA 641
Score = 42.4 bits (98), Expect = 0.002
Identities = 68/307 (22%), Positives = 90/307 (29%), Gaps = 32/307 (10%)
Query: 193 PPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPC 252
P KG A T PAPT P P T S T+ +P K P P
Sbjct: 680 PAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 739
Query: 253 SPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLP 312
P P + + + T + KS D LS EP P
Sbjct: 740 EPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELS-AEPT-----P 793
Query: 313 PPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQ 372
+ P +P P ++ P AT P T T + +R R A K +
Sbjct: 794 KALENSPKEPGVPTTKTPA-ATKPEMT------TTAKDKTTERDLRTTPETTTAAPKMTK 846
Query: 373 RKARMHERIVKQYQDAIRAHKAGRAVD------VAELPVPPGFPPIQGLEATKPTQQSLV 426
A E+ + A + L P + + T T + +
Sbjct: 847 ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMN 906
Query: 427 GVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAP-----PSRTPQSGSAPTAKA 481
ETA P+D P PT PK P P P+ T
Sbjct: 907 KPEETAK--------PKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPT 958
Query: 482 PPKATST 488
P K TST
Sbjct: 959 PRKMTST 965
Score = 39.7 bits (91), Expect = 0.014
Identities = 74/358 (20%), Positives = 116/358 (32%), Gaps = 30/358 (8%)
Query: 150 AIESARQAGDSAKMRRYDRGLKTLENLLASIR--KGNAIDEADIPPPVAI---GKG---- 200
+ E R+ A+ ++YD+ E+ A ++ K N + P P + G G
Sbjct: 77 SFERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 136
Query: 201 -------PASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCS 253
ST ++ T P A PR +L S T+ +S + K +
Sbjct: 137 DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKET 196
Query: 254 PGPLAQLQSRQRDYKLAALHAKQQGDTTAA--ARHFRVAKSFDAVLEALSRGEPVDLSCL 311
Q + ++ +A + T+A A +V E ++G +
Sbjct: 197 TTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE 256
Query: 312 PPPPDQLPPDPPSPPSQPPTPATAPS--TTEVPPPPRTLLEALEQRMERYQVAAAQAKSK 369
P P P +P S + PTP T S TT P P T A E +
Sbjct: 257 PTPTT--PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPT 314
Query: 370 GDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFP-PIQGLEATKPTQQSLVGV 428
+ A + + A K+ P P P P E T +
Sbjct: 315 TPKEPAPTTTK-----EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPT 369
Query: 429 LETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKAT 486
++ P ++ P P APT PK P TP+ + T K P T
Sbjct: 370 TPKEPAPTTKEPAPTTPKEPAPTAPKKP-APTT-PKEPAPTTPKEPAPTTTKEPSPTT 425
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 52.8 bits (125), Expect = 2e-06
Identities = 86/385 (22%), Positives = 119/385 (30%), Gaps = 49/385 (12%)
Query: 120 TPPPVAQPKPEAPHPGL----ETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLE- 174
T P + KP P P L +T+ + L + + ++ + K D KT
Sbjct: 207 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 266
Query: 175 NLLASIRKGNAIDEADI------PPPVA--IGKGPASTPTYSPAPTQPAPRIASAP-EPR 225
SI K +A D A P P A KGPA T P PT P ++ P EP
Sbjct: 267 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 326
Query: 226 VTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAAR 285
T + T P P P P P + A K+ TT
Sbjct: 327 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP-------APTTPKEPAPTTT--- 376
Query: 286 HFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPP 345
P P P + P P P+ P TP TT P P
Sbjct: 377 ---------------KEPAPTTTKSAPTTPKEPAPTTPKKPA-PTTPKEPAPTTPKEPTP 420
Query: 346 RTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAE-LP 404
T E E + ++ A + + A K E P
Sbjct: 421 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPK-----EPAPTTPKEPAPTTTKEPSP 475
Query: 405 VPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPK 464
P P ++ T + + ++ P ++ P P APT PK
Sbjct: 476 TTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP-APTT-PK 533
Query: 465 APPSRTPQSGSAPTAKAPPKATSTR 489
P TP+ APT P T+T+
Sbjct: 534 KPAPTTPKE-PAPTTPKEPAPTTTK 557
Score = 48.5 bits (114), Expect = 3e-05
Identities = 68/319 (21%), Positives = 94/319 (29%), Gaps = 33/319 (10%)
Query: 192 PPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGP 251
P P P +T +P T+ AP P P T E T +P K P P
Sbjct: 481 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 540
Query: 252 CSPGPLAQLQ-SRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVL-EALSRGEPVDLS 309
P P + + K A K+ TT K E L+ P +
Sbjct: 541 KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 600
Query: 310 CLPPPPDQLPPDPPSPPS-------QPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVA 362
P P++L P P P+ P TP A T P P T E + + A
Sbjct: 601 --PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPK--EPA 656
Query: 363 AAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEAT---- 418
K +K+ A + P P P E T
Sbjct: 657 PTTPKETAPTTPKGTAPTTLKE-----------PAPTTPKKPAPKELAPTTTKEPTSTTC 705
Query: 419 -KPTQQSLVGVLETAMK----LANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQS 473
KP + G T K ++ P + P P T + AP P +
Sbjct: 706 DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 765
Query: 474 GSAPTAKAPPKATSTRAQQ 492
PT+ K T ++
Sbjct: 766 TKGPTSTTSDKPAPTTPKE 784
Score = 46.2 bits (108), Expect = 1e-04
Identities = 73/359 (20%), Positives = 112/359 (31%), Gaps = 38/359 (10%)
Query: 199 KGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLA 258
KG A T PAPT P P T E S T +P K P P P P
Sbjct: 669 KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 728
Query: 259 QLQSRQRDYK-LAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPP--P 315
+ K A K+ TT + + ++G S P P P
Sbjct: 729 PKEPAPTTPKGTAPTTLKEPAPTTPK------KPAPKELAPTTTKGPTSTTSDKPAPTTP 782
Query: 316 DQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKA 375
+ P P P+ AP+T E PPP + + E + + +S +
Sbjct: 783 KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE---- 838
Query: 376 RMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKL 435
+ A +A++ P PG P + ATKP + T L
Sbjct: 839 -------------LSAEPTPKALE--NSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDL 883
Query: 436 ANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLA 495
E ++ K+ + T + K + T + + P K T+ +
Sbjct: 884 RTTPE-TTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAP 942
Query: 496 FLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVN 554
+ KK + + K + + K +K P P TK P P +
Sbjct: 943 KVTTTKKTITTTEIMNKPEETAK-PKDRATNSKATTPK--------PQKPTKAPKKPTS 992
Score = 45.4 bits (106), Expect = 2e-04
Identities = 73/299 (24%), Positives = 98/299 (32%), Gaps = 29/299 (9%)
Query: 202 ASTPTYSPAPTQP---APRIASAPEPRVTLEGPSATAP-ASSPGLAKPQMPPGPCSPGPL 257
A T PAPT P AP P P T E P+ T P A++P K P P P P
Sbjct: 592 APTTPEKPAPTTPEELAPTTPEEPTP-TTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT 650
Query: 258 AQLQSRQRDYK-LAALHAKQQGDTT-AAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPP 315
+ K A K TT K L + EP +C P P
Sbjct: 651 TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 710
Query: 316 DQLPPDPPSPPSQ--PPTPATAPSTTEVPPPPRTLLE---ALEQRMERYQVAAAQAKSKG 370
P+ P + P TP TT P TL E ++ ++A K
Sbjct: 711 TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 770
Query: 371 DQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLE 430
+ K+ A P P PP E + PT
Sbjct: 771 STTSDKPAPTTPKETAPTTPKEPA-PTTPKKPAPTTPETPPPTTSEVSTPTTTK----EP 825
Query: 431 TAMKLANQDEGPEDEEDEVPKK-QNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATST 488
T + + + PE + PK +NSP +P P ++TP A P+ T+T
Sbjct: 826 TTIHKSPDESTPELSAEPTPKALENSP----KEPGVPTTKTP-------AATKPEMTTT 873
Score = 43.5 bits (101), Expect = 0.001
Identities = 65/309 (21%), Positives = 92/309 (29%), Gaps = 31/309 (10%)
Query: 193 PPVAIGKGPASTPTYSPAPT--QPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPG 250
P K P T PAPT +PAP P P + T +P K P
Sbjct: 410 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 469
Query: 251 PCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSC 310
P P + K A K+ TT + + + + P +
Sbjct: 470 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKE--- 526
Query: 311 LPPPPDQLPPDPPSPPSQPPT--PATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKS 368
P P P P +P PT AP+TT+ P P A E +
Sbjct: 527 -PAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 585
Query: 369 KGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGV 428
++ A K P P P E PT
Sbjct: 586 TTPEKLA------------PTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTP----- 628
Query: 429 LETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATST 488
+ A ++ P ++ P P T + AP T G+APT P T+
Sbjct: 629 -KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAP---TTPKGTAPTTLKEPAPTTP 684
Query: 489 R--AQQQLA 495
+ A ++LA
Sbjct: 685 KKPAPKELA 693
Score = 42.4 bits (98), Expect = 0.002
Identities = 68/307 (22%), Positives = 90/307 (29%), Gaps = 32/307 (10%)
Query: 193 PPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPC 252
P KG A T PAPT P P T S T+ +P K P P
Sbjct: 732 PAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 791
Query: 253 SPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLP 312
P P + + + T + KS D LS EP P
Sbjct: 792 EPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELS-AEPT-----P 845
Query: 313 PPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQ 372
+ P +P P ++ P AT P T T + +R R A K +
Sbjct: 846 KALENSPKEPGVPTTKTPA-ATKPEMT------TTAKDKTTERDLRTTPETTTAAPKMTK 898
Query: 373 RKARMHERIVKQYQDAIRAHKAGRAVD------VAELPVPPGFPPIQGLEATKPTQQSLV 426
A E+ + A + L P + + T T + +
Sbjct: 899 ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMN 958
Query: 427 GVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAP-----PSRTPQSGSAPTAKA 481
ETA P+D P PT PK P P P+ T
Sbjct: 959 KPEETAK--------PKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPT 1010
Query: 482 PPKATST 488
P K TST
Sbjct: 1011 PRKMTST 1017
Score = 35.8 bits (81), Expect = 0.20
Identities = 72/355 (20%), Positives = 113/355 (31%), Gaps = 30/355 (8%)
Query: 149 TAIESARQAGDSAKMRRYDRGLKTLENLLASIRK------------GNAIDEADIPPPVA 196
+ I + + +SA R + LK +N +K G+ +D D
Sbjct: 136 STIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFK---- 191
Query: 197 IGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGP 256
+ ST ++ T P A PR +L S T+ +S + K +
Sbjct: 192 VTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTT 251
Query: 257 LAQLQSRQRDYKLAALHAKQQGDTTAA--ARHFRVAKSFDAVLEALSRGEPVDLSCLPPP 314
Q + ++ +A + T+A A +V E ++G + P P
Sbjct: 252 NKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTP 311
Query: 315 PDQLPPDPPSPPSQPPTPATAPS--TTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQ 372
P +P S + PTP T S TT P P T A E + +
Sbjct: 312 TT--PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPK 369
Query: 373 RKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFP-PIQGLEATKPTQQSLVGVLET 431
A + + A K+ P P P P E T +
Sbjct: 370 EPAPTTTK-----EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPK 424
Query: 432 AMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKAT 486
++ P ++ P P APT PK P TP+ + T K P T
Sbjct: 425 EPAPTTKEPAPTTPKEPAPTAPKKP-APTT-PKEPAPTTPKEPAPTTTKEPSPTT 477
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 52.8 bits (125), Expect = 2e-06
Identities = 86/385 (22%), Positives = 119/385 (30%), Gaps = 49/385 (12%)
Query: 120 TPPPVAQPKPEAPHPGL----ETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLE- 174
T P + KP P P L +T+ + L + + ++ + K D KT
Sbjct: 248 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 307
Query: 175 NLLASIRKGNAIDEADI------PPPVA--IGKGPASTPTYSPAPTQPAPRIASAP-EPR 225
SI K +A D A P P A KGPA T P PT P ++ P EP
Sbjct: 308 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 367
Query: 226 VTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAAR 285
T + T P P P P P + A K+ TT
Sbjct: 368 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP-------APTTPKEPAPTTT--- 417
Query: 286 HFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPP 345
P P P + P P P+ P TP TT P P
Sbjct: 418 ---------------KEPAPTTTKSAPTTPKEPAPTTPKKPA-PTTPKEPAPTTPKEPTP 461
Query: 346 RTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAE-LP 404
T E E + ++ A + + A K E P
Sbjct: 462 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPK-----EPAPTTPKEPAPTTTKEPSP 516
Query: 405 VPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPK 464
P P ++ T + + ++ P ++ P P APT PK
Sbjct: 517 TTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP-APTT-PK 574
Query: 465 APPSRTPQSGSAPTAKAPPKATSTR 489
P TP+ APT P T+T+
Sbjct: 575 KPAPTTPKE-PAPTTPKEPAPTTTK 598
Score = 48.5 bits (114), Expect = 3e-05
Identities = 68/319 (21%), Positives = 94/319 (29%), Gaps = 33/319 (10%)
Query: 192 PPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGP 251
P P P +T +P T+ AP P P T E T +P K P P
Sbjct: 522 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 581
Query: 252 CSPGPLAQLQ-SRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVL-EALSRGEPVDLS 309
P P + + K A K+ TT K E L+ P +
Sbjct: 582 KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 641
Query: 310 CLPPPPDQLPPDPPSPPS-------QPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVA 362
P P++L P P P+ P TP A T P P T E + + A
Sbjct: 642 --PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPK--EPA 697
Query: 363 AAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEAT---- 418
K +K+ A + P P P E T
Sbjct: 698 PTTPKETAPTTPKGTAPTTLKE-----------PAPTTPKKPAPKELAPTTTKEPTSTTC 746
Query: 419 -KPTQQSLVGVLETAMK----LANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQS 473
KP + G T K ++ P + P P T + AP P +
Sbjct: 747 DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 806
Query: 474 GSAPTAKAPPKATSTRAQQ 492
PT+ K T ++
Sbjct: 807 TKGPTSTTSDKPAPTTPKE 825
Score = 46.2 bits (108), Expect = 1e-04
Identities = 73/359 (20%), Positives = 112/359 (31%), Gaps = 38/359 (10%)
Query: 199 KGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLA 258
KG A T PAPT P P T E S T +P K P P P P
Sbjct: 710 KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 769
Query: 259 QLQSRQRDYK-LAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPP--P 315
+ K A K+ TT + + ++G S P P P
Sbjct: 770 PKEPAPTTPKGTAPTTLKEPAPTTPK------KPAPKELAPTTTKGPTSTTSDKPAPTTP 823
Query: 316 DQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKA 375
+ P P P+ AP+T E PPP + + E + + +S +
Sbjct: 824 KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE---- 879
Query: 376 RMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKL 435
+ A +A++ P PG P + ATKP + T L
Sbjct: 880 -------------LSAEPTPKALE--NSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDL 924
Query: 436 ANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLA 495
E ++ K+ + T + K + T + + P K T+ +
Sbjct: 925 RTTPE-TTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAP 983
Query: 496 FLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVN 554
+ KK + + K + + K +K P P TK P P +
Sbjct: 984 KVTTTKKTITTTEIMNKPEETAK-PKDRATNSKATTPK--------PQKPTKAPKKPTS 1033
Score = 45.4 bits (106), Expect = 2e-04
Identities = 73/299 (24%), Positives = 98/299 (32%), Gaps = 29/299 (9%)
Query: 202 ASTPTYSPAPTQP---APRIASAPEPRVTLEGPSATAP-ASSPGLAKPQMPPGPCSPGPL 257
A T PAPT P AP P P T E P+ T P A++P K P P P P
Sbjct: 633 APTTPEKPAPTTPEELAPTTPEEPTP-TTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT 691
Query: 258 AQLQSRQRDYK-LAALHAKQQGDTT-AAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPP 315
+ K A K TT K L + EP +C P P
Sbjct: 692 TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 751
Query: 316 DQLPPDPPSPPSQ--PPTPATAPSTTEVPPPPRTLLE---ALEQRMERYQVAAAQAKSKG 370
P+ P + P TP TT P TL E ++ ++A K
Sbjct: 752 TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 811
Query: 371 DQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLE 430
+ K+ A P P PP E + PT
Sbjct: 812 STTSDKPAPTTPKETAPTTPKEPA-PTTPKKPAPTTPETPPPTTSEVSTPTTTK----EP 866
Query: 431 TAMKLANQDEGPEDEEDEVPKK-QNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATST 488
T + + + PE + PK +NSP +P P ++TP A P+ T+T
Sbjct: 867 TTIHKSPDESTPELSAEPTPKALENSP----KEPGVPTTKTP-------AATKPEMTTT 914
Score = 43.5 bits (101), Expect = 0.001
Identities = 65/309 (21%), Positives = 92/309 (29%), Gaps = 31/309 (10%)
Query: 193 PPVAIGKGPASTPTYSPAPT--QPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPG 250
P K P T PAPT +PAP P P + T +P K P
Sbjct: 451 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 510
Query: 251 PCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSC 310
P P + K A K+ TT + + + + P +
Sbjct: 511 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKE--- 567
Query: 311 LPPPPDQLPPDPPSPPSQPPT--PATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKS 368
P P P P +P PT AP+TT+ P P A E +
Sbjct: 568 -PAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 626
Query: 369 KGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGV 428
++ A K P P P E PT
Sbjct: 627 TTPEKLA------------PTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTP----- 669
Query: 429 LETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATST 488
+ A ++ P ++ P P T + AP T G+APT P T+
Sbjct: 670 -KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAP---TTPKGTAPTTLKEPAPTTP 725
Query: 489 R--AQQQLA 495
+ A ++LA
Sbjct: 726 KKPAPKELA 734
Score = 42.4 bits (98), Expect = 0.002
Identities = 68/307 (22%), Positives = 90/307 (29%), Gaps = 32/307 (10%)
Query: 193 PPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPC 252
P KG A T PAPT P P T S T+ +P K P P
Sbjct: 773 PAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 832
Query: 253 SPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLP 312
P P + + + T + KS D LS EP P
Sbjct: 833 EPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELS-AEPT-----P 886
Query: 313 PPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQ 372
+ P +P P ++ P AT P T T + +R R A K +
Sbjct: 887 KALENSPKEPGVPTTKTPA-ATKPEMT------TTAKDKTTERDLRTTPETTTAAPKMTK 939
Query: 373 RKARMHERIVKQYQDAIRAHKAGRAVD------VAELPVPPGFPPIQGLEATKPTQQSLV 426
A E+ + A + L P + + T T + +
Sbjct: 940 ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMN 999
Query: 427 GVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAP-----PSRTPQSGSAPTAKA 481
ETA P+D P PT PK P P P+ T
Sbjct: 1000 KPEETAK--------PKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPT 1051
Query: 482 PPKATST 488
P K TST
Sbjct: 1052 PRKMTST 1058
Score = 35.8 bits (81), Expect = 0.20
Identities = 72/355 (20%), Positives = 113/355 (31%), Gaps = 30/355 (8%)
Query: 149 TAIESARQAGDSAKMRRYDRGLKTLENLLASIRK------------GNAIDEADIPPPVA 196
+ I + + +SA R + LK +N +K G+ +D D
Sbjct: 177 STIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFK---- 232
Query: 197 IGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGP 256
+ ST ++ T P A PR +L S T+ +S + K +
Sbjct: 233 VTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTT 292
Query: 257 LAQLQSRQRDYKLAALHAKQQGDTTAA--ARHFRVAKSFDAVLEALSRGEPVDLSCLPPP 314
Q + ++ +A + T+A A +V E ++G + P P
Sbjct: 293 NKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTP 352
Query: 315 PDQLPPDPPSPPSQPPTPATAPS--TTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQ 372
P +P S + PTP T S TT P P T A E + +
Sbjct: 353 TT--PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPK 410
Query: 373 RKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFP-PIQGLEATKPTQQSLVGVLET 431
A + + A K+ P P P P E T +
Sbjct: 411 EPAPTTTK-----EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPK 465
Query: 432 AMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKAT 486
++ P ++ P P APT PK P TP+ + T K P T
Sbjct: 466 EPAPTTKEPAPTTPKEPAPTAPKKP-APTT-PKEPAPTTPKEPAPTTTKEPSPTT 518
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 52.8 bits (125), Expect = 2e-06
Identities = 76/325 (23%), Positives = 100/325 (30%), Gaps = 59/325 (18%)
Query: 205 PTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQ 264
P SP P P AS P P P P P PP P P P QS
Sbjct: 607 PPLSPQPKIVTPYTASQPSP-----------PLPPPPPPPPPPPPPPPPPPPPLPSQSAP 655
Query: 265 RDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPS 324
A + K T F + + + V L PP +PP PP
Sbjct: 656 SAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP 715
Query: 325 PPSQPPTPAT----------APSTTE----------------------VPPPPRTLLEAL 352
PP PPTP + APS + PPPP + L
Sbjct: 716 PP--PPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPL 773
Query: 353 EQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPI 412
+ + A + + + + K A + +P P PP+
Sbjct: 774 PPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPV 833
Query: 413 QGLEATKPTQQS---------LVGVLETAMKLANQ---DEGPEDEEDEVPKKQNSPVAPT 460
T P QQS L V ++A+Q P E + K + VAP
Sbjct: 834 PVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQ 893
Query: 461 AQP--KAPPSRTPQSGSAPTAKAPP 483
+ P KA P P S P+ PP
Sbjct: 894 SPPAVKAKPKWQPSSIPVPSPDFPP 918
Score = 51.6 bits (122), Expect = 3e-06
Identities = 48/179 (26%), Positives = 64/179 (35%), Gaps = 27/179 (15%)
Query: 192 PPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEG-----------PSATAPASSP 240
P P+ P ST T +P TQ AP + P P + P+ P P
Sbjct: 779 PKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPP 838
Query: 241 GLAKPQM-----PPGPCSPGP--LAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSF 293
L K Q PP P SP P + Q+ S+ Q A VA
Sbjct: 839 TLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPA----NVAPQS 894
Query: 294 DAVLEALSRGEPVDLSCL-----PPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRT 347
++A + +P + PPPP+ PP PPS P P P T P P ++
Sbjct: 895 PPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKS 953
Score = 45.4 bits (106), Expect = 2e-04
Identities = 87/430 (20%), Positives = 135/430 (31%), Gaps = 101/430 (23%)
Query: 121 PPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENL---- 176
PPP P P P P L + +SA AG +A M + L+N
Sbjct: 634 PPPPPPPPPPPPPPPLPS-------------QSAPSAGSAAPMFVKYSTITRLQNASQHS 680
Query: 177 -------LASIRKGNAIDEADIPPPVAIGKGPASTPT----------YSPAPTQPAPRIA 219
+ + ++ + PP + P P PAP P+
Sbjct: 681 GALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQF 740
Query: 220 SAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGD 279
SAP P + + +A P PP P P PL + L + A
Sbjct: 741 SAPPPPLKIHQVQHITQ-----VAPPTPPPPPPIPAPLPPQAPPK---PLVTIPAPTSTK 792
Query: 280 TTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPP-------PPDQLPPDPPSPPSQPPTP 332
T A P +PP P +PP PP+PP P P
Sbjct: 793 TVAPV--------------VTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPP 838
Query: 333 ATAPSTT---EVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAI 389
+ + PP P + + ++ +++ + Q + + Q A+
Sbjct: 839 TLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAV 898
Query: 390 RAHKAGRAVDVAELPVP-PGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDE 448
+A + + +PVP P FPP P + SLV + P
Sbjct: 899 KAKPKWQP---SSIPVPSPDFPP-------PPPESSLVFPPPPPSPVPAPPPPPPPTASP 948
Query: 449 VPKKQNSPVAPTAQPKAP----PSRTPQSGSA---------PTAK-----------APPK 484
P K SP T++ +P P TPQ S+ P K PP
Sbjct: 949 TPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPA 1008
Query: 485 ATSTRAQQQL 494
+ + +++ L
Sbjct: 1009 ESGSPSKETL 1018
Score = 37.7 bits (86), Expect = 0.051
Identities = 65/321 (20%), Positives = 99/321 (30%), Gaps = 38/321 (11%)
Query: 192 PPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKP------ 245
PP K PA +Y P P+ P P + P P + + P SP P
Sbjct: 808 PPVPPAKKQPAFPASYIP-PSPPTPPVP-VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI 865
Query: 246 --QMPPGPCSPG----PLAQLQSRQRDYKLAALHAK---QQGDTTAAARHFRVAKSFDAV 296
Q PP P P PL + + A+ AK Q + F ++
Sbjct: 866 ASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSL 925
Query: 297 LEALSRGEPVDLSCLPPPPD-QLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQR 355
+ PV PPPP PD P + + ++P + PP P+
Sbjct: 926 VFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQ--------- 976
Query: 356 MERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGL 415
+ ++ + ++ + + K A + + P PG + G+
Sbjct: 977 -RNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGV 1035
Query: 416 EATKPTQQSLVGVLETAMKLANQD---EGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQ 472
QQ V + +D E P D P P + PP P
Sbjct: 1036 NLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSD----SDFPPPPPETELPLPPIEIPA 1091
Query: 473 SGSAPTAKAPPKATSTRAQQQ 493
S T+ PK Q Q
Sbjct: 1092 VFSGNTS---PKVAVVNPQPQ 1109
Score = 35.4 bits (80), Expect = 0.25
Identities = 22/67 (32%), Positives = 31/67 (46%), Gaps = 3/67 (4%)
Query: 285 RHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPP---DPPSPPSQPPTPATAPSTTEV 341
R ++ +S A +E+++R + L P P + P PSPP PP P P
Sbjct: 583 RGTQLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPP 642
Query: 342 PPPPRTL 348
PPPP L
Sbjct: 643 PPPPPPL 649
Score = 31.2 bits (69), Expect = 4.8
Identities = 32/126 (25%), Positives = 52/126 (41%), Gaps = 8/126 (6%)
Query: 85 DEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPHPGLETT----L 140
DE+ + G +ED + D DL LGE K +++ +P P + T
Sbjct: 6 DEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQETNMANF 65
Query: 141 QERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKG 200
R ++Y + A G++ + L ++E L+SI GN+ + I A K
Sbjct: 66 SYRFSIYN--LNEALNQGETVDLDALMADLCSIEQELSSIGSGNS--KRQITETKATQKL 121
Query: 201 PASTPT 206
P S T
Sbjct: 122 PVSRHT 127
>gi|116256464 hypothetical protein LOC343990 [Homo sapiens]
Length = 962
Score = 52.8 bits (125), Expect = 2e-06
Identities = 157/679 (23%), Positives = 222/679 (32%), Gaps = 134/679 (19%)
Query: 6 GPPGP-PGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVGGQPPALEKLKG 64
GPP P P G A AR+ L S + E G E+ + +P + L+
Sbjct: 294 GPPAPLPPPGGARARR-ARLQHSSALTASVEEGGVPGEDPSSRPATPELAEPESAPTLRV 352
Query: 65 KGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPPPV 124
+ P P P+ G D + + + ++ P V
Sbjct: 353 EPPSP--------------PEGPPNPGPDGGKQDGEAPPAGPCAPATDKAEEVVCAPEDV 398
Query: 125 AQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKG- 183
A P P A G +TT E + SAR + R + + +L KG
Sbjct: 399 ASPFPTAIPEG-DTTPPETDPAATSEAPSARDGPE----RSVPKEAEPTPPVLPDEEKGP 453
Query: 184 -----NAIDEADIPPPVAIGKGP---ASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATA 235
EA+ P G P + P+ +PAP+ PAP+ P EG
Sbjct: 454 PGPAPEPEREAETEPERGAGTEPERIGTEPSTAPAPSPPAPKSCLKHRPAAASEG----- 508
Query: 236 PASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAA--------ARHF 287
PA+SP LA + PP PG L + K A G AA
Sbjct: 509 PAASPPLAAAESPPVEPGPGSLDAEAAAPERPKAERAEAPPAGAERAAPERKAERGGAEL 568
Query: 288 RVAKSFDA-------------VLE------ALSRGEPV--------DLSCLPPPPDQLP- 319
R AK F LE L+R PV DL LP P P
Sbjct: 569 RGAKKFSVSSCRARPRPGVSRPLERASGRLPLARSGPVWRSEAALDDLQGLPEPQHAKPG 628
Query: 320 ----------------PDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAA 363
P P P A AP T E P P A + + V
Sbjct: 629 PRKLAERGPQDSGDRAASPAGPRKSPQEAAAAPGTRE--PCPAAQEPAPSEDRNPFPVKL 686
Query: 364 AQAKSKGDQRKARMHE-RIVKQYQDAIRAHKAGRAVDVAE---LPVPPGF-----PPIQG 414
R E + VK+Y +R ++ + E L P P QG
Sbjct: 687 RSTSLSLKYRDGASQEVKGVKRYSAEVRLERSLTVLPKEEKCPLGTAPALRGTRAPSDQG 746
Query: 415 LEATKPTQ----------QSLVGVLETAMKLANQDEGPEDEE--DEVPKKQNSPVAPTAQ 462
+P + + L+ + A D GP + E E + P+ A+
Sbjct: 747 KGKARPPEPLSSKPPLPRKPLLQSFTLPHQPAPPDAGPGEREPRKEPRTAEKRPLRRGAE 806
Query: 463 PKAPPSRT-PQSGSAPTAKAPPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAK 521
PP+ T P + P APP T TR Q++ L+ Q + R + + AK
Sbjct: 807 KSLPPAATGPGADGQP---APPWITVTR-QKRRGTLDQPPNQEDKPGARTLKSEPGKQAK 862
Query: 522 MHLRQAKGLEPMLEA----SRNGLPVDITKVPPAPVNKDDFALVQRPG---------PGL 568
+ +G EP+ +A S++ L IT V PA K L + G L
Sbjct: 863 V---PERGQEPVKQADFVRSKSFL---ITPVKPAVDRKQGAKLNFKEGLQRGISLSHQNL 916
Query: 569 SQEAARRYGELTKLIRQQH 587
+Q A EL +L R +
Sbjct: 917 AQSAVMMEKELHQLKRASY 935
Score = 32.7 bits (73), Expect = 1.7
Identities = 82/372 (22%), Positives = 112/372 (30%), Gaps = 53/372 (14%)
Query: 223 EPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTA 282
E + LE P+S P P P P PL A
Sbjct: 265 EEKPLLEVSPEERPSSGQQDVAPDRGPEPGPPAPLPPPGG-------------------A 305
Query: 283 AARHFRVAKSFDAVLEALSRGEP-VDLSCLPPPPDQLPPD--------PPSPPSQPPTPA 333
AR R+ S G P D S P P+ P+ PPSPP PP P
Sbjct: 306 RARRARLQHSSALTASVEEGGVPGEDPSSRPATPELAEPESAPTLRVEPPSPPEGPPNPG 365
Query: 334 TAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHK 393
+ PP + E +V A A D +
Sbjct: 366 PDGGKQDGEAPPAGPCAPATDKAE--EVVCAPEDVASPFPTAIPEGDTTPPETDPAATSE 423
Query: 394 AGRAVDVAELPVP---PGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVP 450
A A D E VP PP+ E P + E + G E + +
Sbjct: 424 APSARDGPERSVPKEAEPTPPVLPDEEKGPPGPAPEPEREAE---TEPERGAGTEPERIG 480
Query: 451 KKQNSPVAPTAQPKAPPS---RTPQSGSAPTAKAPPKATSTRAQQQLAFLEGRKKQLLQA 507
+ ++ AP P AP S P + S A +PP A + + L A
Sbjct: 481 TEPST--APAPSPPAPKSCLKHRPAAASEGPAASPPLAAAESPPVEPG------PGSLDA 532
Query: 508 ALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVNKDDFALVQRPGPG 567
A ++ E A+ A+ P +A R G + K + RP PG
Sbjct: 533 EAAAPERPKAERAEAPPAGAERAAPERKAERGGAELRGAK------KFSVSSCRARPRPG 586
Query: 568 LSQEAARRYGEL 579
+S+ R G L
Sbjct: 587 VSRPLERASGRL 598
Score = 31.6 bits (70), Expect = 3.7
Identities = 83/381 (21%), Positives = 109/381 (28%), Gaps = 70/381 (18%)
Query: 3 KRKGPPGP---PGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVGGQPPAL 59
+ KGPPGP P R A + G G E + E PPA
Sbjct: 449 EEKGPPGPAPEPEREAETEPERGA--------------GTEPERIGTEPSTAPAPSPPAP 494
Query: 60 EK-LKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKAS 118
+ LK + E L + E G D EA E KA
Sbjct: 495 KSCLKHRPAAASEGPAASPPLAAAE-SPPVEPGPGSLDAEA----------AAPERPKAE 543
Query: 119 ETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDR--GLKTLENL 176
P A + AP E E + ++ S R R +R G L
Sbjct: 544 RAEAPPAGAERAAPERKAERGGAELRGAKKFSVSSCRARPRPGVSRPLERASGRLPLARS 603
Query: 177 LASIRKGNAIDEAD-IPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATA 235
R A+D+ +P P GP P + R AS PR S
Sbjct: 604 GPVWRSEAALDDLQGLPEPQHAKPGPRKLAERGPQDS--GDRAASPAGPR-----KSPQE 656
Query: 236 PASSPGLAKPQMPPGPCSPGPLAQLQS---RQRDYKLAALHAKQQGDTTAAARHFRVAKS 292
A++PG +P P P P + R L+ + + +
Sbjct: 657 AAAAPGTREPC--PAAQEPAPSEDRNPFPVKLRSTSLSLKYRDGASQEVKGVKRYSAEVR 714
Query: 293 FDAVLEALSRGEPVDLSCLPP----------------PPDQLPPDPPSP----------P 326
+ L L + E L P PP+ L PP P P
Sbjct: 715 LERSLTVLPKEEKCPLGTAPALRGTRAPSDQGKGKARPPEPLSSKPPLPRKPLLQSFTLP 774
Query: 327 SQPPTPATAPSTTEVPPPPRT 347
QP P P E PRT
Sbjct: 775 HQPAPPDAGPGEREPRKEPRT 795
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 52.4 bits (124), Expect = 2e-06
Identities = 49/166 (29%), Positives = 69/166 (41%), Gaps = 31/166 (18%)
Query: 191 IPPPVAIGKGPASTPTYSPAP--TQPAPRIASAPEP---RVTLEGPSATAPASSPGL--- 242
+PPP + PA P SP P TQP P++ +P P +V L GP + + G
Sbjct: 1211 LPPPEGEARKPAKPPV-SPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPP 1269
Query: 243 AKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSR 302
P+ PP P +P P+ +A L + G + A + A+ A L A
Sbjct: 1270 VSPKPPPPPTAPKPVK---------AVAGLPSGSAGPSPAPS----PARQPPAAL-AKPP 1315
Query: 303 GEPVDLSCLPPPPDQLPPDPPSP----PSQPPTPATAPSTTEVPPP 344
G P L P PP P +P P++PP A A + PP
Sbjct: 1316 GTPPSLGASPAK----PPSPGAPALHVPAKPPRAAAAAAAAAAAPP 1357
Score = 46.6 bits (109), Expect = 1e-04
Identities = 117/538 (21%), Positives = 171/538 (31%), Gaps = 97/538 (18%)
Query: 3 KRKGPPGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVGGQPPALEKL 62
++KGPP PP + +++A L D P PEDG L+G
Sbjct: 941 RKKGPPPPPPKRSSSALASANLAD-EPVPDAEPEDG------------LLG--------- 978
Query: 63 KGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPP 122
+ + C R D T + EL+ + G + A P
Sbjct: 979 -------------VRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPE 1025
Query: 123 PVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLK-TLENLLASIR 181
P+P +P PG R+A +++ G ++ R L + LLA+ R
Sbjct: 1026 GHPTPRPASPEPG-------RVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATAR 1078
Query: 182 KGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPG 241
+G + AD P V G G + PR S E V EGP +S
Sbjct: 1079 RGPG-ESADPGPFVEDGTG------------RQRPRGPSKGEAGV--EGPPLAKVEASAT 1123
Query: 242 LAKPQMPPGPCSPGPLAQLQSRQRDYKLAALH---------AKQQGDTTAAARHFRVAKS 292
L + + Q++Q + K AK++ V +
Sbjct: 1124 LKRR-----------IRAKQNQQENVKFILTESDTVKRRPKAKEREAGPEPPPPLSVYHN 1172
Query: 293 FDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEAL 352
+ E LPPPP P P PP P + PP + L
Sbjct: 1173 GTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVL 1232
Query: 353 EQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPP- 411
Q + + Q + K E VK RAH G V+ P PP P
Sbjct: 1233 TQPVPKLQGSPTPTSKKVPLPGPGSPE--VK------RAH--GTPPPVSPKPPPPPTAPK 1282
Query: 412 ----IQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPP 467
+ GL + + G P K SP AP A P
Sbjct: 1283 PVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKP 1342
Query: 468 SRTPQSGSAPTA--KAPPKATS--TRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAK 521
R + +A A APP+ S A+Q+L LQA ++ D +G +
Sbjct: 1343 PRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQEDAQGPR 1400
Score = 38.1 bits (87), Expect = 0.039
Identities = 73/323 (22%), Positives = 104/323 (32%), Gaps = 57/323 (17%)
Query: 202 ASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQM----PPGPCSPGPL 257
A T PT P P PR T S+ + + ++ PPGP SP
Sbjct: 664 AMTGPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSP--- 720
Query: 258 AQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQ 317
SR ++Y L G AR R S G+P + LPP
Sbjct: 721 ---MSRSQEYLLD--EGPAPGTPPREARPGRHGHSIKRASVPPVPGKPRQV--LPPGTSH 773
Query: 318 LPPDPPSPPSQPPTPAT-------APSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKG 370
P ++P +P AP+T +V P P+ LL E+ M S
Sbjct: 774 FTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQ-LLPPTERPM-----------SPR 821
Query: 371 DQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPG-----FPPIQGLEATKPTQQSL 425
++ H + A A PVP PP E +P +++
Sbjct: 822 SLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRA- 880
Query: 426 VGVLETAMKLANQDEGPEDEEDEVPK-------------KQNSPVAPTAQPKAPPSRTPQ 472
+ + A D PE +E VP + +S AP K +R+
Sbjct: 881 ----HSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADK-NVNRSQS 935
Query: 473 SGSAPTAKAPPKATSTRAQQQLA 495
P K PP R+ LA
Sbjct: 936 FAVRPRKKGPPPPPPKRSSSALA 958
Score = 37.4 bits (85), Expect = 0.067
Identities = 98/470 (20%), Positives = 149/470 (31%), Gaps = 88/470 (18%)
Query: 66 GPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKA-SETPPPV 124
GPL +A + + + + P E D + +EL++ L +E P
Sbjct: 616 GPLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGPTT 675
Query: 125 AQPKPEAPHPGLETTLQERLALYQTAIESARQA-------GDSAKMRRYDRGLK------ 171
+P P TT Q+ + S+ Q G S+ M R L
Sbjct: 676 EKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPAP 735
Query: 172 -TLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEG 230
T R G++I A +PP GK P + T P + P L G
Sbjct: 736 GTPPREARPGRHGHSIKRASVPP--VPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQALGG 793
Query: 231 PSATAPASSPGLAKPQMPP---GPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHF 287
P APA++ PQ+ P P SP L Q +
Sbjct: 794 PHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTH------------------------ 829
Query: 288 RVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRT 347
+ F VL +PV+ P P P PP P+ PT P P P+
Sbjct: 830 ---RGFAYVLP-----QPVEGEVGPAAPG---PAPPPVPTAVPTLCLPPEADAEPGRPKK 878
Query: 348 LLEALE---------QRMERYQVAAAQAKSKGDQRKARMH---------ERIVKQYQDAI 389
+L +R E AAA + +R R H + + + A+
Sbjct: 879 RAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAV 938
Query: 390 RAHKAG-------------RAVDVAELPVPPGFPP--IQGLEATKPTQQSLVGVLETAMK 434
R K G + ++A+ PVP P + G+ A L G ++T
Sbjct: 939 RPRKKGPPPPPPKRSSSALASANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSA 998
Query: 435 LANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPK 484
+ + E + + P P +P+ G T A K
Sbjct: 999 GSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRPASPEPGRVATVLASVK 1048
Score = 36.2 bits (82), Expect = 0.15
Identities = 64/273 (23%), Positives = 101/273 (36%), Gaps = 39/273 (14%)
Query: 55 QPPALEKLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDE-----DDLEADDDLLAELNE 109
+P A E+ G P P ++ + +R E+ G E E LA L
Sbjct: 1151 RPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPP 1210
Query: 110 VLGEEQKASETPPPVAQPKPEAPHP-----GLETTLQERLALYQTAIESARQAGD----- 159
+ E +A + P PKP P G T +++ L ++A
Sbjct: 1211 LPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPV 1270
Query: 160 SAKMRRYDRGLKTLENLLASIRKGNA-IDEADIP---PPVAIGKGPASTPTYS------P 209
S K K ++ +A + G+A A P PP A+ K P + P+ P
Sbjct: 1271 SPKPPPPPTAPKPVK-AVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPP 1329
Query: 210 APTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKL 269
+P PA + + P PR A A++ A P PP SPG A+ + + L
Sbjct: 1330 SPGAPALHVPAKP-PR--------AAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACL 1380
Query: 270 A----ALHAKQQGDTTAAARHFRVAKSFDAVLE 298
A A+ K + + R KS ++L+
Sbjct: 1381 AAALQAVEEKIRQEDAQGPRDSAAEKSTGSILD 1413
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 855
Score = 52.0 bits (123), Expect = 3e-06
Identities = 89/406 (21%), Positives = 143/406 (35%), Gaps = 53/406 (13%)
Query: 110 VLGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAK------- 162
V + ++ P P A+ +P A GL+ L+ T + S ++G SA+
Sbjct: 209 VSSASEHSTTEPSPAARRRPSAGG-GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPA 267
Query: 163 --MRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIAS 220
+ +GL+ L + + +A P + P +TP+ S A AP
Sbjct: 268 HPSQPKPKGLQALRPPQVTPPRKDAA-----PALGPLSSSPLATPSPSAALQSQAP---- 318
Query: 221 APEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDT 280
P T S T ++P P PP P +P L L S Q T
Sbjct: 319 -PTLPATPHSSSLTCQLATP---LPLAPPSPSAPPSLQTLPSPPAT-------PPSQATT 367
Query: 281 TAAARHFRVAKSF--DAVLEALSRGEPVDLSCLPPPPDQLPPDPP-SPPSQP---PTP-- 332
+ + + SF L L+ P L PP Q PP PP SPP P P+P
Sbjct: 368 SLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQA 427
Query: 333 --ATAPSTTEVP--PPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDA 388
A A + P PPP ++A + A+ S ++ +
Sbjct: 428 PNALAVHLLQAPFSPPPSPPVQA------PFSPPASPPVSPSATPPSQAPPSLAAPPLQV 481
Query: 389 IRAHKAGRAVDVAELPVPPGFPPIQG--LEATKPTQQSLVGVLETAMKLANQDEGPEDEE 446
+ A + + P P PP+ L+ KP Q+ + ++ +
Sbjct: 482 PPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQ 541
Query: 447 DEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQ 492
+ P++P A PP + P +AP + PP ++ Q
Sbjct: 542 APFSPSASLPMSPLA---TPPPQAPPVLAAPLLQVPPSPPASPTLQ 584
Score = 51.2 bits (121), Expect = 4e-06
Identities = 85/370 (22%), Positives = 116/370 (31%), Gaps = 90/370 (24%)
Query: 121 PPPVAQPKP--EAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLA 178
P P A+P+P E P + + + A AG + R R L + L+
Sbjct: 192 PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ-RPASRSLSSSATPLS 250
Query: 179 SIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPAS 238
S P G TP P+QP P+ A P APA
Sbjct: 251 S--------------PARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296
Query: 239 SPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLE 298
P + P +P P A LQS+ A H+
Sbjct: 297 GPLSSSPL-----ATPSPSAALQSQAPPTLPATPHSSS---------------------- 329
Query: 299 ALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMER 358
L+C P LP PPSP S PP+ T PS PP T
Sbjct: 330 ---------LTCQLATP--LPLAPPSP-SAPPSLQTLPSPPATPPSQATT---------- 367
Query: 359 YQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAH--KAGRAVDVAEL---PVPPGFPPIQ 413
S G H + + +A A+ + L P PP PP+
Sbjct: 368 ---------SLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLS 418
Query: 414 GLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQS 473
L P + + V + + P P + +P +P A P PS TP S
Sbjct: 419 PLATPSPQAPNALAV--------HLLQAPFSPPPSPPVQ--APFSPPASPPVSPSATPPS 468
Query: 474 GSAPTAKAPP 483
+ P+ APP
Sbjct: 469 QAPPSLAAPP 478
Score = 46.6 bits (109), Expect = 1e-04
Identities = 82/311 (26%), Positives = 110/311 (35%), Gaps = 60/311 (19%)
Query: 193 PPVAIGKGP---ASTPTYSPAPTQPAP-RIASAPEPRVTLEGPSATAPASSPGLAKPQMP 248
P A GP A T + +PA PA R AP + T GP SSPG A
Sbjct: 71 PESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGP-----VSSPGRAS---- 121
Query: 249 PGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDL 308
G PGPL Q+ +++A +G T A + ALS G D
Sbjct: 122 -GTTRPGPLG-----QKGLRISAEETVARGKATEAPKR-----------SALSAGARRDT 164
Query: 309 SCLPP--PPDQLPPDPPSPPSQPPTPATAPSTTEVPP---PPRTLLEALEQRMERYQVAA 363
S P P + + ++ P APS PP P +++ A E AA
Sbjct: 165 SGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAA 224
Query: 364 AQAKSKGD--QRKA-RMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKP 420
+ S G QR A R R+ + R A P P P +GL+A +P
Sbjct: 225 RRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA--PAHPSQPKPKGLQALRP 282
Query: 421 TQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAK 480
Q + +D P +P A P PS QS + PT
Sbjct: 283 PQVT------------------PPRKDAAPALGPLSSSPLATPS--PSAALQSQAPPTLP 322
Query: 481 APPKATSTRAQ 491
A P ++S Q
Sbjct: 323 ATPHSSSLTCQ 333
Score = 46.6 bits (109), Expect = 1e-04
Identities = 44/169 (26%), Positives = 63/169 (37%), Gaps = 16/169 (9%)
Query: 193 PPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPC 252
PPV P ++P SP+ T P+ S P + + +P SP P P P
Sbjct: 446 PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPL 505
Query: 253 SPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVL--EALSRGEPVDLSC 310
+ PL + + A Q + A+ + S A L L+ P
Sbjct: 506 AAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV 565
Query: 311 LPPPPDQLPPDPPSPPS-----QPPTPATAPSTT---------EVPPPP 345
L P Q+PP PP+ P+ +PPTP S + PPPP
Sbjct: 566 LAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 614
Score = 42.0 bits (97), Expect = 0.003
Identities = 45/170 (26%), Positives = 62/170 (36%), Gaps = 14/170 (8%)
Query: 192 PPPVAIGKGPASTP---TYSPAPTQP-APRIASAPEPRVTLEGPSATAPASSPGLAKPQM 247
PP A+ PAS P +SP+ + P +P P+ L P P S P Q
Sbjct: 526 PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585
Query: 248 PPGPCSPGPLAQLQSRQRDYKLAA----LHAKQQGDTTAA---ARHFRVAKSFDAVLEAL 300
P P +PGP + + LA ++ T + A H A S L
Sbjct: 586 PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGY 645
Query: 301 SRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATA---PSTTEVPPPPRT 347
G + PPP +L P+ S+ P P A +P PP T
Sbjct: 646 DSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPAT 695
Score = 35.8 bits (81), Expect = 0.20
Identities = 40/154 (25%), Positives = 55/154 (35%), Gaps = 20/154 (12%)
Query: 192 PPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEG-----PSATAPASSPGLAKPQ 246
PPP+A + P P P + + P P + G PSA+ P S PQ
Sbjct: 502 PPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ 561
Query: 247 MPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPV 306
PP +P LQ L A ++ T + S + AL+ G
Sbjct: 562 APPVLAAP----LLQVPPSPPASPTLQAPRRPPTPGP----DTSVSGPRLTLALAPGP-- 611
Query: 307 DLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTE 340
PPPP + P S P ++A ST E
Sbjct: 612 -----PPPPSRSPSSTLSGPDLAGHSSSATSTPE 640
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 52.0 bits (123), Expect = 3e-06
Identities = 117/534 (21%), Positives = 183/534 (34%), Gaps = 101/534 (18%)
Query: 4 RKGP-PGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVG--GQPPALE 60
RKG P PP + AA Q+ + E ++ E L A A V G+ P ++
Sbjct: 371 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK 430
Query: 61 KL---------KGKGPLPMEAIEKMASLCM-----RDPDEDEEEGTDEDDLEADDDLLAE 106
KG GP+P + D + EE +D D E +
Sbjct: 431 PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA 490
Query: 107 LNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRY 166
+ LG +A T P P +A ++ ++ + ES+ ++ DSA
Sbjct: 491 QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPM----DNSESSEESSDSADS--- 543
Query: 167 DRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRV 226
E A++ A IP A P T T + A P AP
Sbjct: 544 -------EEAPAAMTAAQAKPALKIPQTKAC---PKKTNTTASAKVAPVRVGTQAPRKAG 593
Query: 227 TLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARH 286
T P+ ++PA + G +P A+ S + + + + T A
Sbjct: 594 TATSPAGSSPAVAGGTQRP------------AEDSSSSEE-------SDSEEEKTGLAVT 634
Query: 287 FRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPR 346
AKS L+ + PV S LP T P+ T+V +
Sbjct: 635 VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK------------TGPTVTQVKAEKQ 682
Query: 347 TLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKA-------GRAVD 399
E+ E+ + + AA+ A+ K +K + K A RA A G+ V
Sbjct: 683 EDSESSEEESDSEEAAASPAQVKTSVKKTQ-----AKANPAAARAPSAKGTISAPGKVVT 737
Query: 400 VA----ELPVPPGFPPIQGLE---------ATKPTQQSLVGVLETAMKLANQDEGPEDEE 446
A + PP++ + A+ P+ V A +D G +EE
Sbjct: 738 AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE 797
Query: 447 DEVPKK-----QNSPVAPTAQPKA---PPSRTPQSGSAPTAKAPPKATSTRAQQ 492
+ ++ Q P T Q +A P +P+ G+APT PP T A Q
Sbjct: 798 SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT---PPGKTGPSAAQ 848
Score = 48.9 bits (115), Expect = 2e-05
Identities = 121/536 (22%), Positives = 179/536 (33%), Gaps = 86/536 (16%)
Query: 8 PGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLAL----------VGG-QP 56
P PPG+ A A Q E ++EE A L VG
Sbjct: 240 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 299
Query: 57 PALEK-LKGKGPLPM----EAIEK-MASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEV 110
PA E KG P P A+ K A D EE E++ A + +V
Sbjct: 300 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 359
Query: 111 LGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGL 170
A E+P A P P P Q ++ + S+ + DS DR
Sbjct: 360 RAASAPAKESPRKGAAPAP--PRKTGPAAAQVQVGKQEEDSRSSSEESDS------DREA 411
Query: 171 KTLENL--LASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRI--------AS 220
N + + K + A +GKG P P P+ ++ +S
Sbjct: 412 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 471
Query: 221 APEPRVTLEG--PSATAPASSPGL-----AKPQMPPG---PCSPGPLAQLQSRQRDYKLA 270
+ E + +G P+A APA L AKP P P GP+A
Sbjct: 472 SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVA-----------V 520
Query: 271 ALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPP 330
+ A++ D + ++ +S D+ A S P ++ P P + P +
Sbjct: 521 QVKAEKPMDNSESSE-----ESSDS---ADSEEAPAAMTAAQAKPALKIPQTKACPKKTN 572
Query: 331 TPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIR 390
T A+A +V P + ++ A + G QR A E +
Sbjct: 573 TTASA----KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA---EDSSSSEESDSE 625
Query: 391 AHKAGRAVDVAE-------LPVPPGFPPIQGL--EATKPTQQSLVGVLETAMKLANQD-- 439
K G AV V + L V P++G + T P G T +K Q+
Sbjct: 626 EEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDS 685
Query: 440 EGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAK----APPKATSTRAQ 491
E E+E D + T+ K P + AP+AK AP K + AQ
Sbjct: 686 ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 741
Score = 44.7 bits (104), Expect = 4e-04
Identities = 93/443 (20%), Positives = 158/443 (35%), Gaps = 48/443 (10%)
Query: 57 PALEKLKGKGPLPMEAIEKM---ASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGE 113
P + +GP + ++ K A+ P+ED +E D E + + LA++
Sbjct: 757 PQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKT 816
Query: 114 EQ-KASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKT 172
Q +A+ P + K AP P +T SA QAG + D +
Sbjct: 817 HQIRAALAPAKESPRKGAAPTPPGKTG------------PSAAQAG------KQDDSGSS 858
Query: 173 LENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPS 232
E + A+ A + P I P +P PA T + AS P R S
Sbjct: 859 SEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA-GPAATPAQAQAASTP--RKARASES 915
Query: 233 ATAPASSPGLAKPQMPPGPC-SPGPLAQLQSRQRDYKLAALHAKQQGDTTAA-ARHFRVA 290
+SS + +P C +PG + + + A A G +++ +
Sbjct: 916 TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 975
Query: 291 KSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPST---TEVPPPPRT 347
K + +S+ P L L + +QPP T PS+ + V P T
Sbjct: 976 KKQEGPATQVSKKNPASLPLTQAALKVLAQK--ASEAQPPVARTQPSSGVDSAVGTLPAT 1033
Query: 348 LLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPP 407
Q + QAK RK ++ E Q A +A ++ + +
Sbjct: 1034 ----------SPQSTSVQAKGTNKLRKPKLPE-----VQQATKAPESSDDSEDSSDSSSG 1078
Query: 408 GFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPP 467
+G + K + +LVG + + ++ E ED+V S ++ P P
Sbjct: 1079 SEEDGEGPQGAK-SAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTP 1137
Query: 468 SRTPQSGSAPTAKAPPKATSTRA 490
+ + S + P + P +ST A
Sbjct: 1138 ANSQASKATPKLDSSPSVSSTLA 1160
Score = 43.1 bits (100), Expect = 0.001
Identities = 97/444 (21%), Positives = 151/444 (34%), Gaps = 98/444 (22%)
Query: 86 EDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQERLA 145
ED +DE D+E ++ +V A TP A P P PG + +
Sbjct: 201 EDTSSSSDETDVEVKAS--EKILQVRAASAPAKGTPGKGATPAP----PGKAGAVASQTK 254
Query: 146 LYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTP 205
+ +S + +S+ K L AS K + + A P + KG A P
Sbjct: 255 AGKPEEDSESSSEESSDSEEETPAAKALLQAKAS-GKTSQVGAASAPAKESPRKGAAPAP 313
Query: 206 TYSPAP-------------TQPAPRIASAPEPRVTLEGPSATAP----ASSPGLAKPQMP 248
P +Q + + + E PS AP AS+P P+
Sbjct: 314 PGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG 373
Query: 249 PGPCSP---GPLA---QLQSRQRDYKLAALHAKQQGDTTAAARHFRV---AKSFDAVLEA 299
P P GP A Q+ ++ D + ++ + + AA +V KS +
Sbjct: 374 AAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAS 433
Query: 300 LSRGEPVDLSCLPPPPDQLPPDPPSPP-------SQPPTPATAPSTT-EVPPPPRTLLEA 351
P+ P PP ++ P PS S+ + ++ S+ EVP
Sbjct: 434 TMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTA------- 486
Query: 352 LEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPP 411
VA AQ KS G+ +A+ P P
Sbjct: 487 ---------VAPAQEKSLGNILQAK------------------------------PTSSP 507
Query: 412 IQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTP 471
+G P + V V A K + E E+ D ++ +P A TA P + P
Sbjct: 508 AKG----PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE-APAAMTAAQAKPALKIP 562
Query: 472 QSGSAPTAKAPPKATSTRAQQQLA 495
Q+ KA PK T+T A ++A
Sbjct: 563 QT------KACPKKTNTTASAKVA 580
Score = 39.7 bits (91), Expect = 0.014
Identities = 101/464 (21%), Positives = 164/464 (35%), Gaps = 90/464 (19%)
Query: 111 LGEEQKASETPPPVAQP-KPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRG 169
LG ++KA E A+ + P E++ +E A +TA + R A ++ + D
Sbjct: 59 LGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLP 118
Query: 170 LKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLE 229
E A K GK S P PA + + S PR + E
Sbjct: 119 SSMKEKAKAETEKA--------------GKTGNSMP--HPATGKTVANLLSGKSPRKSAE 162
Query: 230 GPSATAPASSPGLAKPQMPP--GPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHF 287
PSA S + +P PG ++ Q+ ++ + + A+ +
Sbjct: 163 -PSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKIL 221
Query: 288 RVAKSFDAVLEALSRGEPVDLSCLPPPP-------DQLPPDPPSPPSQPPTPATAPSTTE 340
+V + A ++G P P PP Q P S+ + ++ S E
Sbjct: 222 QVRAA-----SAPAKGTP-GKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEE 275
Query: 341 VPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDV 400
P + LL+A + + QV AA A +K RK
Sbjct: 276 TPAA-KALLQA-KASGKTSQVGAASAPAKESPRKGAA----------------------- 310
Query: 401 AELPVPPGF--PPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVA 458
P PPG P + +A K + S ++ +E +EE K +
Sbjct: 311 ---PAPPGKTGPAVAKAQAGKREEDSQ----------SSSEESDSEEEAPAQAKPSGKAP 357
Query: 459 PTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVE 518
AP +P+ G+AP APP+ T A Q G++++ +++ +
Sbjct: 358 QVRAASAPAKESPRKGAAP---APPRKTGPAAAQVQV---GKQEEDSRSSSEESDSDREA 411
Query: 519 GAKMHLRQAK--GLEPMLE-ASRNGL--------PVDITKVPPA 551
A M+ Q K G P ++ AS G+ PV KV PA
Sbjct: 412 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPA 455
Score = 35.8 bits (81), Expect = 0.20
Identities = 83/443 (18%), Positives = 139/443 (31%), Gaps = 94/443 (21%)
Query: 83 DPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQE 142
D E EE +D D E + A++ P + P+ +A TT
Sbjct: 529 DNSESSEESSDSADSEEAPAAMT-----------AAQAKPALKIPQTKACPKKTNTTASA 577
Query: 143 RLALYQTAIESARQAG---------------------DSAKMRRYDR-----GLKTLENL 176
++A + ++ R+AG DS+ D GL
Sbjct: 578 KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQ 637
Query: 177 LASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAP 236
S+ KG + A +P ++G+G A PT + + + E +
Sbjct: 638 AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEA 697
Query: 237 ASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAV 296
A+SP K + P AA A T +A K A
Sbjct: 698 AASPAQVKTSVKKTQAKANP-------------AAARAPSAKGTISAP-----GKVVTAA 739
Query: 297 LEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPAT--APSTTEVPPPPRTLLEALEQ 354
+A R P PP + P +T A VP + + A
Sbjct: 740 AQAKQRS----------------PSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA--- 780
Query: 355 RMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQG 414
A AQ + D + ++ + + +G+ + P P +G
Sbjct: 781 -------AQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 833
Query: 415 LEATKPTQQSLVGVLETAMKLANQDE-GPEDEEDEVPKKQNSPVAPTAQPKAP-----PS 468
T P + +A + QD+ G EE + + + V K P P+
Sbjct: 834 AAPTPPGKTG-----PSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPN 888
Query: 469 RTPQSGSAPTAKAPPKATSTRAQ 491
R+P +A A+A +T +A+
Sbjct: 889 RSPAGPAATPAQAQAASTPRKAR 911
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 52.0 bits (123), Expect = 3e-06
Identities = 117/534 (21%), Positives = 183/534 (34%), Gaps = 101/534 (18%)
Query: 4 RKGP-PGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVG--GQPPALE 60
RKG P PP + AA Q+ + E ++ E L A A V G+ P ++
Sbjct: 448 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK 507
Query: 61 KL---------KGKGPLPMEAIEKMASLCM-----RDPDEDEEEGTDEDDLEADDDLLAE 106
KG GP+P + D + EE +D D E +
Sbjct: 508 PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA 567
Query: 107 LNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRY 166
+ LG +A T P P +A ++ ++ + ES+ ++ DSA
Sbjct: 568 QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPM----DNSESSEESSDSADS--- 620
Query: 167 DRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRV 226
E A++ A IP A P T T + A P AP
Sbjct: 621 -------EEAPAAMTAAQAKPALKIPQTKAC---PKKTNTTASAKVAPVRVGTQAPRKAG 670
Query: 227 TLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARH 286
T P+ ++PA + G +P A+ S + + + + T A
Sbjct: 671 TATSPAGSSPAVAGGTQRP------------AEDSSSSEE-------SDSEEEKTGLAVT 711
Query: 287 FRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPR 346
AKS L+ + PV S LP T P+ T+V +
Sbjct: 712 VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK------------TGPTVTQVKAEKQ 759
Query: 347 TLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKA-------GRAVD 399
E+ E+ + + AA+ A+ K +K + K A RA A G+ V
Sbjct: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQ-----AKANPAAARAPSAKGTISAPGKVVT 814
Query: 400 VA----ELPVPPGFPPIQGLE---------ATKPTQQSLVGVLETAMKLANQDEGPEDEE 446
A + PP++ + A+ P+ V A +D G +EE
Sbjct: 815 AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE 874
Query: 447 DEVPKK-----QNSPVAPTAQPKA---PPSRTPQSGSAPTAKAPPKATSTRAQQ 492
+ ++ Q P T Q +A P +P+ G+APT PP T A Q
Sbjct: 875 SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT---PPGKTGPSAAQ 925
Score = 48.9 bits (115), Expect = 2e-05
Identities = 121/536 (22%), Positives = 179/536 (33%), Gaps = 86/536 (16%)
Query: 8 PGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLAL----------VGG-QP 56
P PPG+ A A Q E ++EE A L VG
Sbjct: 317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 57 PALEK-LKGKGPLPM----EAIEK-MASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEV 110
PA E KG P P A+ K A D EE E++ A + +V
Sbjct: 377 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436
Query: 111 LGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGL 170
A E+P A P P P Q ++ + S+ + DS DR
Sbjct: 437 RAASAPAKESPRKGAAPAP--PRKTGPAAAQVQVGKQEEDSRSSSEESDS------DREA 488
Query: 171 KTLENL--LASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRI--------AS 220
N + + K + A +GKG P P P+ ++ +S
Sbjct: 489 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 548
Query: 221 APEPRVTLEG--PSATAPASSPGL-----AKPQMPPG---PCSPGPLAQLQSRQRDYKLA 270
+ E + +G P+A APA L AKP P P GP+A
Sbjct: 549 SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVA-----------V 597
Query: 271 ALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPP 330
+ A++ D + ++ +S D+ A S P ++ P P + P +
Sbjct: 598 QVKAEKPMDNSESSE-----ESSDS---ADSEEAPAAMTAAQAKPALKIPQTKACPKKTN 649
Query: 331 TPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIR 390
T A+A +V P + ++ A + G QR A E +
Sbjct: 650 TTASA----KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA---EDSSSSEESDSE 702
Query: 391 AHKAGRAVDVAE-------LPVPPGFPPIQGL--EATKPTQQSLVGVLETAMKLANQD-- 439
K G AV V + L V P++G + T P G T +K Q+
Sbjct: 703 EEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDS 762
Query: 440 EGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAK----APPKATSTRAQ 491
E E+E D + T+ K P + AP+AK AP K + AQ
Sbjct: 763 ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 818
Score = 43.5 bits (101), Expect = 0.001
Identities = 101/504 (20%), Positives = 173/504 (34%), Gaps = 99/504 (19%)
Query: 87 DEEEGTDEDDLEADDDLLAELNEVLGEE------QKASETPPPVAQPKPEAPHPGLETTL 140
+EEE + + +A L + + VLG + +KA + PHP T+
Sbjct: 89 EEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTV 148
Query: 141 QERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKG 200
L+ G S + TL + A A P V+ G+
Sbjct: 149 ANLLS------------GKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQA 196
Query: 201 PASTPTYSPAPTQ------PAPRIASAPEPRVTLEGPSATAPASSPGLA---KPQMPPGP 251
+S+ S + + P+ + A V+ + A A +PG PQ+ G
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGA 256
Query: 252 CSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVD---- 307
P A+ + + ++++ ++ K+ + +L+ + P
Sbjct: 257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ----VKASEKILQVRAASAPAKGTPG 312
Query: 308 LSCLPPPP-------DQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQ 360
P PP Q P S+ + ++ S E P + LL+A + + Q
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAA-KALLQA-KASGKTSQ 370
Query: 361 VAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGF--PPIQGLEAT 418
V AA A +K RK P PPG P + +A
Sbjct: 371 VGAASAPAKESPRKGAA--------------------------PAPPGKTGPAVAKAQAG 404
Query: 419 KPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPT 478
K + S ++ +E +EE K + AP +P+ G+AP
Sbjct: 405 KREEDSQ----------SSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAP- 453
Query: 479 AKAPPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAK--GLEPMLE- 535
APP+ T A Q G++++ +++ + A M+ Q K G P ++
Sbjct: 454 --APPRKTGPAAAQVQV---GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKP 508
Query: 536 ASRNGL--------PVDITKVPPA 551
AS G+ PV KV PA
Sbjct: 509 ASTMGMGPLGKGAGPVPPGKVGPA 532
Score = 39.7 bits (91), Expect = 0.014
Identities = 97/456 (21%), Positives = 156/456 (34%), Gaps = 109/456 (23%)
Query: 83 DPDEDEEEGTDEDD---------LEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPH 133
+ E EEG++ ++ ++A + +L +V A TP A P P
Sbjct: 268 EESESSEEGSESEEEAPAGTRSQVKASEKIL----QVRAASAPAKGTPGKGATPAP---- 319
Query: 134 PGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPP 193
PG + + + +S + +S+ K L AS K + + A P
Sbjct: 320 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS-GKTSQVGAASAPA 378
Query: 194 PVAIGKGPASTPTYSPAP-------------TQPAPRIASAPEPRVTLEGPSATAP---- 236
+ KG A P P +Q + + + E PS AP
Sbjct: 379 KESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 237 ASSPGLAKPQMPPGPCSP---GPLA---QLQSRQRDYKLAALHAKQQGDTTAAARHFRV- 289
AS+P P+ P P GP A Q+ ++ D + ++ + + AA +V
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 290 --AKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPP-------SQPPTPATAPSTT- 339
KS + P+ P PP ++ P PS S+ + ++ S+
Sbjct: 499 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 340 EVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVD 399
EVP VA AQ KS G+ +A+
Sbjct: 559 EVPTA----------------VAPAQEKSLGNILQAK----------------------- 579
Query: 400 VAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAP 459
P P +G P + V V A K + E E+ D ++ +P A
Sbjct: 580 -------PTSSPAKG----PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE-APAAM 627
Query: 460 TAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLA 495
TA P + PQ+ KA PK T+T A ++A
Sbjct: 628 TAAQAKPALKIPQT------KACPKKTNTTASAKVA 657
Score = 35.8 bits (81), Expect = 0.20
Identities = 83/443 (18%), Positives = 139/443 (31%), Gaps = 94/443 (21%)
Query: 83 DPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQE 142
D E EE +D D E + A++ P + P+ +A TT
Sbjct: 606 DNSESSEESSDSADSEEAPAAMT-----------AAQAKPALKIPQTKACPKKTNTTASA 654
Query: 143 RLALYQTAIESARQAG---------------------DSAKMRRYDR-----GLKTLENL 176
++A + ++ R+AG DS+ D GL
Sbjct: 655 KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQ 714
Query: 177 LASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAP 236
S+ KG + A +P ++G+G A PT + + + E +
Sbjct: 715 AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEA 774
Query: 237 ASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAV 296
A+SP K + P AA A T +A K A
Sbjct: 775 AASPAQVKTSVKKTQAKANP-------------AAARAPSAKGTISAP-----GKVVTAA 816
Query: 297 LEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPAT--APSTTEVPPPPRTLLEALEQ 354
+A R P PP + P +T A VP + + A
Sbjct: 817 AQAKQRS----------------PSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA--- 857
Query: 355 RMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQG 414
A AQ + D + ++ + + +G+ + P P +G
Sbjct: 858 -------AQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 910
Query: 415 LEATKPTQQSLVGVLETAMKLANQDE-GPEDEEDEVPKKQNSPVAPTAQPKAP-----PS 468
T P + +A + QD+ G EE + + + V K P P+
Sbjct: 911 AAPTPPGKTG-----PSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPN 965
Query: 469 RTPQSGSAPTAKAPPKATSTRAQ 491
R+P +A A+A +T +A+
Sbjct: 966 RSPAGPAATPAQAQAASTPRKAR 988
Score = 35.8 bits (81), Expect = 0.20
Identities = 89/439 (20%), Positives = 148/439 (33%), Gaps = 78/439 (17%)
Query: 57 PALEKLKGKGPLPMEAIEKM---ASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGE 113
P + +GP + ++ K A+ P+ED +E D E + + LA++
Sbjct: 834 PQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKT 893
Query: 114 EQ-KASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKT 172
Q +A+ P + K AP P +T SA QAG + D +
Sbjct: 894 HQIRAALAPAKESPRKGAAPTPPGKTG------------PSAAQAG------KQDDSGSS 935
Query: 173 LENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPS 232
E + A+ A + P I P +P PA T + AS P R S
Sbjct: 936 SEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA-GPAATPAQAQAASTP--RKARASES 992
Query: 233 ATAPASSPGLAKPQMPPGPC-SPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAK 291
+SS + +P C +PG + T H R+A
Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNV-------------------VTMPTAHPRIAP 1033
Query: 292 SFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEA 351
+ S+ + S + Q P + PAT+P +T V
Sbjct: 1034 KASMAGASSSK----ESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSV---------- 1079
Query: 352 LEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPP 411
QAK RK ++ E Q A +A ++ + +
Sbjct: 1080 -------------QAKGTNKLRKPKLPE-----VQQATKAPESSDDSEDSSDSSSGSEED 1121
Query: 412 IQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTP 471
+G + K + +LVG + + ++ E ED+V S ++ P P+ +
Sbjct: 1122 GEGPQGAK-SAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQ 1180
Query: 472 QSGSAPTAKAPPKATSTRA 490
S + P + P +ST A
Sbjct: 1181 ASKATPKLDSSPSVSSTLA 1199
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 52.0 bits (123), Expect = 3e-06
Identities = 117/534 (21%), Positives = 183/534 (34%), Gaps = 101/534 (18%)
Query: 4 RKGP-PGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVG--GQPPALE 60
RKG P PP + AA Q+ + E ++ E L A A V G+ P ++
Sbjct: 448 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK 507
Query: 61 KL---------KGKGPLPMEAIEKMASLCM-----RDPDEDEEEGTDEDDLEADDDLLAE 106
KG GP+P + D + EE +D D E +
Sbjct: 508 PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA 567
Query: 107 LNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRY 166
+ LG +A T P P +A ++ ++ + ES+ ++ DSA
Sbjct: 568 QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPM----DNSESSEESSDSADS--- 620
Query: 167 DRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRV 226
E A++ A IP A P T T + A P AP
Sbjct: 621 -------EEAPAAMTAAQAKPALKIPQTKAC---PKKTNTTASAKVAPVRVGTQAPRKAG 670
Query: 227 TLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARH 286
T P+ ++PA + G +P A+ S + + + + T A
Sbjct: 671 TATSPAGSSPAVAGGTQRP------------AEDSSSSEE-------SDSEEEKTGLAVT 711
Query: 287 FRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPR 346
AKS L+ + PV S LP T P+ T+V +
Sbjct: 712 VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK------------TGPTVTQVKAEKQ 759
Query: 347 TLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKA-------GRAVD 399
E+ E+ + + AA+ A+ K +K + K A RA A G+ V
Sbjct: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQ-----AKANPAAARAPSAKGTISAPGKVVT 814
Query: 400 VA----ELPVPPGFPPIQGLE---------ATKPTQQSLVGVLETAMKLANQDEGPEDEE 446
A + PP++ + A+ P+ V A +D G +EE
Sbjct: 815 AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE 874
Query: 447 DEVPKK-----QNSPVAPTAQPKA---PPSRTPQSGSAPTAKAPPKATSTRAQQ 492
+ ++ Q P T Q +A P +P+ G+APT PP T A Q
Sbjct: 875 SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT---PPGKTGPSAAQ 925
Score = 48.9 bits (115), Expect = 2e-05
Identities = 121/536 (22%), Positives = 179/536 (33%), Gaps = 86/536 (16%)
Query: 8 PGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLAL----------VGG-QP 56
P PPG+ A A Q E ++EE A L VG
Sbjct: 317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 57 PALEK-LKGKGPLPM----EAIEK-MASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEV 110
PA E KG P P A+ K A D EE E++ A + +V
Sbjct: 377 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436
Query: 111 LGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGL 170
A E+P A P P P Q ++ + S+ + DS DR
Sbjct: 437 RAASAPAKESPRKGAAPAP--PRKTGPAAAQVQVGKQEEDSRSSSEESDS------DREA 488
Query: 171 KTLENL--LASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRI--------AS 220
N + + K + A +GKG P P P+ ++ +S
Sbjct: 489 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 548
Query: 221 APEPRVTLEG--PSATAPASSPGL-----AKPQMPPG---PCSPGPLAQLQSRQRDYKLA 270
+ E + +G P+A APA L AKP P P GP+A
Sbjct: 549 SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVA-----------V 597
Query: 271 ALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPP 330
+ A++ D + ++ +S D+ A S P ++ P P + P +
Sbjct: 598 QVKAEKPMDNSESSE-----ESSDS---ADSEEAPAAMTAAQAKPALKIPQTKACPKKTN 649
Query: 331 TPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIR 390
T A+A +V P + ++ A + G QR A E +
Sbjct: 650 TTASA----KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA---EDSSSSEESDSE 702
Query: 391 AHKAGRAVDVAE-------LPVPPGFPPIQGL--EATKPTQQSLVGVLETAMKLANQD-- 439
K G AV V + L V P++G + T P G T +K Q+
Sbjct: 703 EEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDS 762
Query: 440 EGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAK----APPKATSTRAQ 491
E E+E D + T+ K P + AP+AK AP K + AQ
Sbjct: 763 ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 818
Score = 43.5 bits (101), Expect = 0.001
Identities = 101/504 (20%), Positives = 173/504 (34%), Gaps = 99/504 (19%)
Query: 87 DEEEGTDEDDLEADDDLLAELNEVLGEE------QKASETPPPVAQPKPEAPHPGLETTL 140
+EEE + + +A L + + VLG + +KA + PHP T+
Sbjct: 89 EEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTV 148
Query: 141 QERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKG 200
L+ G S + TL + A A P V+ G+
Sbjct: 149 ANLLS------------GKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQA 196
Query: 201 PASTPTYSPAPTQ------PAPRIASAPEPRVTLEGPSATAPASSPGLA---KPQMPPGP 251
+S+ S + + P+ + A V+ + A A +PG PQ+ G
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGA 256
Query: 252 CSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVD---- 307
P A+ + + ++++ ++ K+ + +L+ + P
Sbjct: 257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ----VKASEKILQVRAASAPAKGTPG 312
Query: 308 LSCLPPPP-------DQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQ 360
P PP Q P S+ + ++ S E P + LL+A + + Q
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAA-KALLQA-KASGKTSQ 370
Query: 361 VAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGF--PPIQGLEAT 418
V AA A +K RK P PPG P + +A
Sbjct: 371 VGAASAPAKESPRKGAA--------------------------PAPPGKTGPAVAKAQAG 404
Query: 419 KPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPT 478
K + S ++ +E +EE K + AP +P+ G+AP
Sbjct: 405 KREEDSQ----------SSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAP- 453
Query: 479 AKAPPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAK--GLEPMLE- 535
APP+ T A Q G++++ +++ + A M+ Q K G P ++
Sbjct: 454 --APPRKTGPAAAQVQV---GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKP 508
Query: 536 ASRNGL--------PVDITKVPPA 551
AS G+ PV KV PA
Sbjct: 509 ASTMGMGPLGKGAGPVPPGKVGPA 532
Score = 43.5 bits (101), Expect = 0.001
Identities = 114/537 (21%), Positives = 178/537 (33%), Gaps = 81/537 (15%)
Query: 57 PALEKLKGKGPLPMEAIEKM---ASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGE 113
P + +GP + ++ K A+ P+ED +E D E + + LA++
Sbjct: 834 PQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKT 893
Query: 114 EQ-KASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKT 172
Q +A+ P + K AP P +T SA QAG ++ D G +
Sbjct: 894 HQIRAALAPAKESPRKGAAPTPPGKTG------------PSAAQAG-----KQDDSGSSS 936
Query: 173 LENLLASIRKGNAIDEADIPPPVAI------GKGPASTPTYSPAPTQPAPRIASAPEPRV 226
E+ I PP+ GPA+TP + A + P AS R
Sbjct: 937 EESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARS 996
Query: 227 TL-----EGPSATAPASSPGL---------AKPQMPPGPCSPGPLAQLQ-SRQRDYKLAA 271
+ E +PG+ A P++ P G + + SR D K
Sbjct: 997 SSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK--- 1053
Query: 272 LHAKQQGDTTAAARHFRVAKSF-DAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPP 330
KQ+G T ++ + A L+ L++ S PP + P +
Sbjct: 1054 ---KQEGPATQVSKKNPASLPLTQAALKVLAQ----KASEAQPPVARTQPSSGVDSAVGT 1106
Query: 331 TPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQR----KARMHERIVKQYQ 386
PAT+P +T V L + ++ Q A +S D + E + Q
Sbjct: 1107 LPATSPQSTSVQAKGTNKLR--KPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQ 1164
Query: 387 DAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEE 446
A AH G E V + P+Q L G + + AN +
Sbjct: 1165 GAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPK 1224
Query: 447 DEVPKKQNSPVAPTAQPKAPPSRTPQ----------------SGSAPTAKAPPKATSTRA 490
+ +S +A P PQ SG+ P PK +
Sbjct: 1225 LDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNP 1284
Query: 491 QQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITK 547
Q L+ Q L Q + A++ K L +LE R + VD TK
Sbjct: 1285 QASTLALQSNITQCLLG-----QPWPLNEAQVQASVVKVLTELLEQERKKV-VDTTK 1335
Score = 39.7 bits (91), Expect = 0.014
Identities = 97/456 (21%), Positives = 156/456 (34%), Gaps = 109/456 (23%)
Query: 83 DPDEDEEEGTDEDD---------LEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPH 133
+ E EEG++ ++ ++A + +L +V A TP A P P
Sbjct: 268 EESESSEEGSESEEEAPAGTRSQVKASEKIL----QVRAASAPAKGTPGKGATPAP---- 319
Query: 134 PGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPP 193
PG + + + +S + +S+ K L AS K + + A P
Sbjct: 320 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS-GKTSQVGAASAPA 378
Query: 194 PVAIGKGPASTPTYSPAP-------------TQPAPRIASAPEPRVTLEGPSATAP---- 236
+ KG A P P +Q + + + E PS AP
Sbjct: 379 KESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 237 ASSPGLAKPQMPPGPCSP---GPLA---QLQSRQRDYKLAALHAKQQGDTTAAARHFRV- 289
AS+P P+ P P GP A Q+ ++ D + ++ + + AA +V
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 290 --AKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPP-------SQPPTPATAPSTT- 339
KS + P+ P PP ++ P PS S+ + ++ S+
Sbjct: 499 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 340 EVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVD 399
EVP VA AQ KS G+ +A+
Sbjct: 559 EVPTA----------------VAPAQEKSLGNILQAK----------------------- 579
Query: 400 VAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAP 459
P P +G P + V V A K + E E+ D ++ +P A
Sbjct: 580 -------PTSSPAKG----PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE-APAAM 627
Query: 460 TAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLA 495
TA P + PQ+ KA PK T+T A ++A
Sbjct: 628 TAAQAKPALKIPQT------KACPKKTNTTASAKVA 657
Score = 35.8 bits (81), Expect = 0.20
Identities = 83/443 (18%), Positives = 139/443 (31%), Gaps = 94/443 (21%)
Query: 83 DPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQE 142
D E EE +D D E + A++ P + P+ +A TT
Sbjct: 606 DNSESSEESSDSADSEEAPAAMT-----------AAQAKPALKIPQTKACPKKTNTTASA 654
Query: 143 RLALYQTAIESARQAG---------------------DSAKMRRYDR-----GLKTLENL 176
++A + ++ R+AG DS+ D GL
Sbjct: 655 KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQ 714
Query: 177 LASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAP 236
S+ KG + A +P ++G+G A PT + + + E +
Sbjct: 715 AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEA 774
Query: 237 ASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAV 296
A+SP K + P AA A T +A K A
Sbjct: 775 AASPAQVKTSVKKTQAKANP-------------AAARAPSAKGTISAP-----GKVVTAA 816
Query: 297 LEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPAT--APSTTEVPPPPRTLLEALEQ 354
+A R P PP + P +T A VP + + A
Sbjct: 817 AQAKQRS----------------PSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA--- 857
Query: 355 RMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQG 414
A AQ + D + ++ + + +G+ + P P +G
Sbjct: 858 -------AQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 910
Query: 415 LEATKPTQQSLVGVLETAMKLANQDE-GPEDEEDEVPKKQNSPVAPTAQPKAP-----PS 468
T P + +A + QD+ G EE + + + V K P P+
Sbjct: 911 AAPTPPGKTG-----PSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPN 965
Query: 469 RTPQSGSAPTAKAPPKATSTRAQ 491
R+P +A A+A +T +A+
Sbjct: 966 RSPAGPAATPAQAQAASTPRKAR 988
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 52.0 bits (123), Expect = 3e-06
Identities = 117/534 (21%), Positives = 183/534 (34%), Gaps = 101/534 (18%)
Query: 4 RKGP-PGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVG--GQPPALE 60
RKG P PP + AA Q+ + E ++ E L A A V G+ P ++
Sbjct: 371 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK 430
Query: 61 KL---------KGKGPLPMEAIEKMASLCM-----RDPDEDEEEGTDEDDLEADDDLLAE 106
KG GP+P + D + EE +D D E +
Sbjct: 431 PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA 490
Query: 107 LNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRY 166
+ LG +A T P P +A ++ ++ + ES+ ++ DSA
Sbjct: 491 QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPM----DNSESSEESSDSADS--- 543
Query: 167 DRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRV 226
E A++ A IP A P T T + A P AP
Sbjct: 544 -------EEAPAAMTAAQAKPALKIPQTKAC---PKKTNTTASAKVAPVRVGTQAPRKAG 593
Query: 227 TLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARH 286
T P+ ++PA + G +P A+ S + + + + T A
Sbjct: 594 TATSPAGSSPAVAGGTQRP------------AEDSSSSEE-------SDSEEEKTGLAVT 634
Query: 287 FRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPR 346
AKS L+ + PV S LP T P+ T+V +
Sbjct: 635 VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK------------TGPTVTQVKAEKQ 682
Query: 347 TLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKA-------GRAVD 399
E+ E+ + + AA+ A+ K +K + K A RA A G+ V
Sbjct: 683 EDSESSEEESDSEEAAASPAQVKTSVKKTQ-----AKANPAAARAPSAKGTISAPGKVVT 737
Query: 400 VA----ELPVPPGFPPIQGLE---------ATKPTQQSLVGVLETAMKLANQDEGPEDEE 446
A + PP++ + A+ P+ V A +D G +EE
Sbjct: 738 AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE 797
Query: 447 DEVPKK-----QNSPVAPTAQPKA---PPSRTPQSGSAPTAKAPPKATSTRAQQ 492
+ ++ Q P T Q +A P +P+ G+APT PP T A Q
Sbjct: 798 SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT---PPGKTGPSAAQ 848
Score = 48.9 bits (115), Expect = 2e-05
Identities = 121/536 (22%), Positives = 179/536 (33%), Gaps = 86/536 (16%)
Query: 8 PGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLAL----------VGG-QP 56
P PPG+ A A Q E ++EE A L VG
Sbjct: 240 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 299
Query: 57 PALEK-LKGKGPLPM----EAIEK-MASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEV 110
PA E KG P P A+ K A D EE E++ A + +V
Sbjct: 300 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 359
Query: 111 LGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGL 170
A E+P A P P P Q ++ + S+ + DS DR
Sbjct: 360 RAASAPAKESPRKGAAPAP--PRKTGPAAAQVQVGKQEEDSRSSSEESDS------DREA 411
Query: 171 KTLENL--LASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRI--------AS 220
N + + K + A +GKG P P P+ ++ +S
Sbjct: 412 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 471
Query: 221 APEPRVTLEG--PSATAPASSPGL-----AKPQMPPG---PCSPGPLAQLQSRQRDYKLA 270
+ E + +G P+A APA L AKP P P GP+A
Sbjct: 472 SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVA-----------V 520
Query: 271 ALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPP 330
+ A++ D + ++ +S D+ A S P ++ P P + P +
Sbjct: 521 QVKAEKPMDNSESSE-----ESSDS---ADSEEAPAAMTAAQAKPALKIPQTKACPKKTN 572
Query: 331 TPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIR 390
T A+A +V P + ++ A + G QR A E +
Sbjct: 573 TTASA----KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA---EDSSSSEESDSE 625
Query: 391 AHKAGRAVDVAE-------LPVPPGFPPIQGL--EATKPTQQSLVGVLETAMKLANQD-- 439
K G AV V + L V P++G + T P G T +K Q+
Sbjct: 626 EEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDS 685
Query: 440 EGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAK----APPKATSTRAQ 491
E E+E D + T+ K P + AP+AK AP K + AQ
Sbjct: 686 ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 741
Score = 43.5 bits (101), Expect = 0.001
Identities = 114/537 (21%), Positives = 178/537 (33%), Gaps = 81/537 (15%)
Query: 57 PALEKLKGKGPLPMEAIEKM---ASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGE 113
P + +GP + ++ K A+ P+ED +E D E + + LA++
Sbjct: 757 PQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKT 816
Query: 114 EQ-KASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKT 172
Q +A+ P + K AP P +T SA QAG ++ D G +
Sbjct: 817 HQIRAALAPAKESPRKGAAPTPPGKTG------------PSAAQAG-----KQDDSGSSS 859
Query: 173 LENLLASIRKGNAIDEADIPPPVAI------GKGPASTPTYSPAPTQPAPRIASAPEPRV 226
E+ I PP+ GPA+TP + A + P AS R
Sbjct: 860 EESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARS 919
Query: 227 TL-----EGPSATAPASSPGL---------AKPQMPPGPCSPGPLAQLQ-SRQRDYKLAA 271
+ E +PG+ A P++ P G + + SR D K
Sbjct: 920 SSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK--- 976
Query: 272 LHAKQQGDTTAAARHFRVAKSF-DAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPP 330
KQ+G T ++ + A L+ L++ S PP + P +
Sbjct: 977 ---KQEGPATQVSKKNPASLPLTQAALKVLAQ----KASEAQPPVARTQPSSGVDSAVGT 1029
Query: 331 TPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQR----KARMHERIVKQYQ 386
PAT+P +T V L + ++ Q A +S D + E + Q
Sbjct: 1030 LPATSPQSTSVQAKGTNKLR--KPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQ 1087
Query: 387 DAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEE 446
A AH G E V + P+Q L G + + AN +
Sbjct: 1088 GAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPK 1147
Query: 447 DEVPKKQNSPVAPTAQPKAPPSRTPQ----------------SGSAPTAKAPPKATSTRA 490
+ +S +A P PQ SG+ P PK +
Sbjct: 1148 LDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNP 1207
Query: 491 QQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITK 547
Q L+ Q L Q + A++ K L +LE R + VD TK
Sbjct: 1208 QASTLALQSNITQCLLG-----QPWPLNEAQVQASVVKVLTELLEQERKKV-VDTTK 1258
Score = 43.1 bits (100), Expect = 0.001
Identities = 97/444 (21%), Positives = 151/444 (34%), Gaps = 98/444 (22%)
Query: 86 EDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQERLA 145
ED +DE D+E ++ +V A TP A P P PG + +
Sbjct: 201 EDTSSSSDETDVEVKAS--EKILQVRAASAPAKGTPGKGATPAP----PGKAGAVASQTK 254
Query: 146 LYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTP 205
+ +S + +S+ K L AS K + + A P + KG A P
Sbjct: 255 AGKPEEDSESSSEESSDSEEETPAAKALLQAKAS-GKTSQVGAASAPAKESPRKGAAPAP 313
Query: 206 TYSPAP-------------TQPAPRIASAPEPRVTLEGPSATAP----ASSPGLAKPQMP 248
P +Q + + + E PS AP AS+P P+
Sbjct: 314 PGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG 373
Query: 249 PGPCSP---GPLA---QLQSRQRDYKLAALHAKQQGDTTAAARHFRV---AKSFDAVLEA 299
P P GP A Q+ ++ D + ++ + + AA +V KS +
Sbjct: 374 AAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAS 433
Query: 300 LSRGEPVDLSCLPPPPDQLPPDPPSPP-------SQPPTPATAPSTT-EVPPPPRTLLEA 351
P+ P PP ++ P PS S+ + ++ S+ EVP
Sbjct: 434 TMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTA------- 486
Query: 352 LEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPP 411
VA AQ KS G+ +A+ P P
Sbjct: 487 ---------VAPAQEKSLGNILQAK------------------------------PTSSP 507
Query: 412 IQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTP 471
+G P + V V A K + E E+ D ++ +P A TA P + P
Sbjct: 508 AKG----PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE-APAAMTAAQAKPALKIP 562
Query: 472 QSGSAPTAKAPPKATSTRAQQQLA 495
Q+ KA PK T+T A ++A
Sbjct: 563 QT------KACPKKTNTTASAKVA 580
Score = 39.7 bits (91), Expect = 0.014
Identities = 101/464 (21%), Positives = 164/464 (35%), Gaps = 90/464 (19%)
Query: 111 LGEEQKASETPPPVAQP-KPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRG 169
LG ++KA E A+ + P E++ +E A +TA + R A ++ + D
Sbjct: 59 LGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLP 118
Query: 170 LKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLE 229
E A K GK S P PA + + S PR + E
Sbjct: 119 SSMKEKAKAETEKA--------------GKTGNSMP--HPATGKTVANLLSGKSPRKSAE 162
Query: 230 GPSATAPASSPGLAKPQMPP--GPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHF 287
PSA S + +P PG ++ Q+ ++ + + A+ +
Sbjct: 163 -PSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKIL 221
Query: 288 RVAKSFDAVLEALSRGEPVDLSCLPPPP-------DQLPPDPPSPPSQPPTPATAPSTTE 340
+V + A ++G P P PP Q P S+ + ++ S E
Sbjct: 222 QVRAA-----SAPAKGTP-GKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEE 275
Query: 341 VPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDV 400
P + LL+A + + QV AA A +K RK
Sbjct: 276 TPAA-KALLQA-KASGKTSQVGAASAPAKESPRKGAA----------------------- 310
Query: 401 AELPVPPGF--PPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVA 458
P PPG P + +A K + S ++ +E +EE K +
Sbjct: 311 ---PAPPGKTGPAVAKAQAGKREEDSQ----------SSSEESDSEEEAPAQAKPSGKAP 357
Query: 459 PTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVE 518
AP +P+ G+AP APP+ T A Q G++++ +++ +
Sbjct: 358 QVRAASAPAKESPRKGAAP---APPRKTGPAAAQVQV---GKQEEDSRSSSEESDSDREA 411
Query: 519 GAKMHLRQAK--GLEPMLE-ASRNGL--------PVDITKVPPA 551
A M+ Q K G P ++ AS G+ PV KV PA
Sbjct: 412 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPA 455
Score = 35.8 bits (81), Expect = 0.20
Identities = 83/443 (18%), Positives = 139/443 (31%), Gaps = 94/443 (21%)
Query: 83 DPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQE 142
D E EE +D D E + A++ P + P+ +A TT
Sbjct: 529 DNSESSEESSDSADSEEAPAAMT-----------AAQAKPALKIPQTKACPKKTNTTASA 577
Query: 143 RLALYQTAIESARQAG---------------------DSAKMRRYDR-----GLKTLENL 176
++A + ++ R+AG DS+ D GL
Sbjct: 578 KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQ 637
Query: 177 LASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAP 236
S+ KG + A +P ++G+G A PT + + + E +
Sbjct: 638 AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEA 697
Query: 237 ASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAV 296
A+SP K + P AA A T +A K A
Sbjct: 698 AASPAQVKTSVKKTQAKANP-------------AAARAPSAKGTISAP-----GKVVTAA 739
Query: 297 LEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPAT--APSTTEVPPPPRTLLEALEQ 354
+A R P PP + P +T A VP + + A
Sbjct: 740 AQAKQRS----------------PSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA--- 780
Query: 355 RMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQG 414
A AQ + D + ++ + + +G+ + P P +G
Sbjct: 781 -------AQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 833
Query: 415 LEATKPTQQSLVGVLETAMKLANQDE-GPEDEEDEVPKKQNSPVAPTAQPKAP-----PS 468
T P + +A + QD+ G EE + + + V K P P+
Sbjct: 834 AAPTPPGKTG-----PSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPN 888
Query: 469 RTPQSGSAPTAKAPPKATSTRAQ 491
R+P +A A+A +T +A+
Sbjct: 889 RSPAGPAATPAQAQAASTPRKAR 911
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 52.0 bits (123), Expect = 3e-06
Identities = 117/534 (21%), Positives = 183/534 (34%), Gaps = 101/534 (18%)
Query: 4 RKGP-PGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVG--GQPPALE 60
RKG P PP + AA Q+ + E ++ E L A A V G+ P ++
Sbjct: 448 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK 507
Query: 61 KL---------KGKGPLPMEAIEKMASLCM-----RDPDEDEEEGTDEDDLEADDDLLAE 106
KG GP+P + D + EE +D D E +
Sbjct: 508 PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA 567
Query: 107 LNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRY 166
+ LG +A T P P +A ++ ++ + ES+ ++ DSA
Sbjct: 568 QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPM----DNSESSEESSDSADS--- 620
Query: 167 DRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRV 226
E A++ A IP A P T T + A P AP
Sbjct: 621 -------EEAPAAMTAAQAKPALKIPQTKAC---PKKTNTTASAKVAPVRVGTQAPRKAG 670
Query: 227 TLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARH 286
T P+ ++PA + G +P A+ S + + + + T A
Sbjct: 671 TATSPAGSSPAVAGGTQRP------------AEDSSSSEE-------SDSEEEKTGLAVT 711
Query: 287 FRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPR 346
AKS L+ + PV S LP T P+ T+V +
Sbjct: 712 VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK------------TGPTVTQVKAEKQ 759
Query: 347 TLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKA-------GRAVD 399
E+ E+ + + AA+ A+ K +K + K A RA A G+ V
Sbjct: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQ-----AKANPAAARAPSAKGTISAPGKVVT 814
Query: 400 VA----ELPVPPGFPPIQGLE---------ATKPTQQSLVGVLETAMKLANQDEGPEDEE 446
A + PP++ + A+ P+ V A +D G +EE
Sbjct: 815 AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE 874
Query: 447 DEVPKK-----QNSPVAPTAQPKA---PPSRTPQSGSAPTAKAPPKATSTRAQQ 492
+ ++ Q P T Q +A P +P+ G+APT PP T A Q
Sbjct: 875 SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT---PPGKTGPSAAQ 925
Score = 48.9 bits (115), Expect = 2e-05
Identities = 121/536 (22%), Positives = 179/536 (33%), Gaps = 86/536 (16%)
Query: 8 PGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLAL----------VGG-QP 56
P PPG+ A A Q E ++EE A L VG
Sbjct: 317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 57 PALEK-LKGKGPLPM----EAIEK-MASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEV 110
PA E KG P P A+ K A D EE E++ A + +V
Sbjct: 377 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436
Query: 111 LGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGL 170
A E+P A P P P Q ++ + S+ + DS DR
Sbjct: 437 RAASAPAKESPRKGAAPAP--PRKTGPAAAQVQVGKQEEDSRSSSEESDS------DREA 488
Query: 171 KTLENL--LASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRI--------AS 220
N + + K + A +GKG P P P+ ++ +S
Sbjct: 489 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 548
Query: 221 APEPRVTLEG--PSATAPASSPGL-----AKPQMPPG---PCSPGPLAQLQSRQRDYKLA 270
+ E + +G P+A APA L AKP P P GP+A
Sbjct: 549 SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVA-----------V 597
Query: 271 ALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPP 330
+ A++ D + ++ +S D+ A S P ++ P P + P +
Sbjct: 598 QVKAEKPMDNSESSE-----ESSDS---ADSEEAPAAMTAAQAKPALKIPQTKACPKKTN 649
Query: 331 TPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIR 390
T A+A +V P + ++ A + G QR A E +
Sbjct: 650 TTASA----KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA---EDSSSSEESDSE 702
Query: 391 AHKAGRAVDVAE-------LPVPPGFPPIQGL--EATKPTQQSLVGVLETAMKLANQD-- 439
K G AV V + L V P++G + T P G T +K Q+
Sbjct: 703 EEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDS 762
Query: 440 EGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAK----APPKATSTRAQ 491
E E+E D + T+ K P + AP+AK AP K + AQ
Sbjct: 763 ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 818
Score = 43.5 bits (101), Expect = 0.001
Identities = 101/504 (20%), Positives = 173/504 (34%), Gaps = 99/504 (19%)
Query: 87 DEEEGTDEDDLEADDDLLAELNEVLGEE------QKASETPPPVAQPKPEAPHPGLETTL 140
+EEE + + +A L + + VLG + +KA + PHP T+
Sbjct: 89 EEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTV 148
Query: 141 QERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKG 200
L+ G S + TL + A A P V+ G+
Sbjct: 149 ANLLS------------GKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQA 196
Query: 201 PASTPTYSPAPTQ------PAPRIASAPEPRVTLEGPSATAPASSPGLA---KPQMPPGP 251
+S+ S + + P+ + A V+ + A A +PG PQ+ G
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGA 256
Query: 252 CSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVD---- 307
P A+ + + ++++ ++ K+ + +L+ + P
Sbjct: 257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ----VKASEKILQVRAASAPAKGTPG 312
Query: 308 LSCLPPPP-------DQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQ 360
P PP Q P S+ + ++ S E P + LL+A + + Q
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAA-KALLQA-KASGKTSQ 370
Query: 361 VAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGF--PPIQGLEAT 418
V AA A +K RK P PPG P + +A
Sbjct: 371 VGAASAPAKESPRKGAA--------------------------PAPPGKTGPAVAKAQAG 404
Query: 419 KPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPT 478
K + S ++ +E +EE K + AP +P+ G+AP
Sbjct: 405 KREEDSQ----------SSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAP- 453
Query: 479 AKAPPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAK--GLEPMLE- 535
APP+ T A Q G++++ +++ + A M+ Q K G P ++
Sbjct: 454 --APPRKTGPAAAQVQV---GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKP 508
Query: 536 ASRNGL--------PVDITKVPPA 551
AS G+ PV KV PA
Sbjct: 509 ASTMGMGPLGKGAGPVPPGKVGPA 532
Score = 39.7 bits (91), Expect = 0.014
Identities = 97/456 (21%), Positives = 156/456 (34%), Gaps = 109/456 (23%)
Query: 83 DPDEDEEEGTDEDD---------LEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPH 133
+ E EEG++ ++ ++A + +L +V A TP A P P
Sbjct: 268 EESESSEEGSESEEEAPAGTRSQVKASEKIL----QVRAASAPAKGTPGKGATPAP---- 319
Query: 134 PGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPP 193
PG + + + +S + +S+ K L AS K + + A P
Sbjct: 320 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS-GKTSQVGAASAPA 378
Query: 194 PVAIGKGPASTPTYSPAP-------------TQPAPRIASAPEPRVTLEGPSATAP---- 236
+ KG A P P +Q + + + E PS AP
Sbjct: 379 KESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 237 ASSPGLAKPQMPPGPCSP---GPLA---QLQSRQRDYKLAALHAKQQGDTTAAARHFRV- 289
AS+P P+ P P GP A Q+ ++ D + ++ + + AA +V
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 290 --AKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPP-------SQPPTPATAPSTT- 339
KS + P+ P PP ++ P PS S+ + ++ S+
Sbjct: 499 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 340 EVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVD 399
EVP VA AQ KS G+ +A+
Sbjct: 559 EVPTA----------------VAPAQEKSLGNILQAK----------------------- 579
Query: 400 VAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAP 459
P P +G P + V V A K + E E+ D ++ +P A
Sbjct: 580 -------PTSSPAKG----PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE-APAAM 627
Query: 460 TAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLA 495
TA P + PQ+ KA PK T+T A ++A
Sbjct: 628 TAAQAKPALKIPQT------KACPKKTNTTASAKVA 657
Score = 35.8 bits (81), Expect = 0.20
Identities = 83/443 (18%), Positives = 139/443 (31%), Gaps = 94/443 (21%)
Query: 83 DPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQE 142
D E EE +D D E + A++ P + P+ +A TT
Sbjct: 606 DNSESSEESSDSADSEEAPAAMT-----------AAQAKPALKIPQTKACPKKTNTTASA 654
Query: 143 RLALYQTAIESARQAG---------------------DSAKMRRYDR-----GLKTLENL 176
++A + ++ R+AG DS+ D GL
Sbjct: 655 KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQ 714
Query: 177 LASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAP 236
S+ KG + A +P ++G+G A PT + + + E +
Sbjct: 715 AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEA 774
Query: 237 ASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAV 296
A+SP K + P AA A T +A K A
Sbjct: 775 AASPAQVKTSVKKTQAKANP-------------AAARAPSAKGTISAP-----GKVVTAA 816
Query: 297 LEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPAT--APSTTEVPPPPRTLLEALEQ 354
+A R P PP + P +T A VP + + A
Sbjct: 817 AQAKQRS----------------PSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA--- 857
Query: 355 RMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQG 414
A AQ + D + ++ + + +G+ + P P +G
Sbjct: 858 -------AQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 910
Query: 415 LEATKPTQQSLVGVLETAMKLANQDE-GPEDEEDEVPKKQNSPVAPTAQPKAP-----PS 468
T P + +A + QD+ G EE + + + V K P P+
Sbjct: 911 AAPTPPGKTG-----PSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPN 965
Query: 469 RTPQSGSAPTAKAPPKATSTRAQ 491
R+P +A A+A +T +A+
Sbjct: 966 RSPAGPAATPAQAQAASTPRKAR 988
Score = 34.7 bits (78), Expect = 0.43
Identities = 99/459 (21%), Positives = 166/459 (36%), Gaps = 61/459 (13%)
Query: 57 PALEKLKGKGPLPMEAIEKM---ASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGE 113
P + +GP + ++ K A+ P+ED +E D E + + LA++
Sbjct: 834 PQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKT 893
Query: 114 EQ-KASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKT 172
Q +A+ P + K AP P +T SA QAG ++ D G +
Sbjct: 894 HQIRAALAPAKESPRKGAAPTPPGKTG------------PSAAQAG-----KQDDSGSSS 936
Query: 173 LENLLASIRKGNAIDEADIPPPVAI------GKGPASTPTYSPAPTQPAPRIASAPEPRV 226
E+ I PP+ GPA+TP + A + PR A A E
Sbjct: 937 EESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAAS--TPRKARASE--- 991
Query: 227 TLEGPSATAPASSPGLAKPQMPPGPC-SPG--------PLAQLQSRQRDYKLAALHAKQQ 277
S +SS + +P C +PG P A + + A +K+
Sbjct: 992 -----STARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKES 1046
Query: 278 GDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPS 337
+ + A D+ + L P S ++L P P Q T AP
Sbjct: 1047 SRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKL-RKPKLPEVQQAT--KAPE 1103
Query: 338 TTEVPPPPRTLLEALEQRMERYQVAAAQAKSKG---DQRKARMHERIVKQYQDAIRAHKA 394
+++ E+ E Q A A + G + + + E + +D + A
Sbjct: 1104 SSDDSEDSSDSSSGSEEDGEGPQ-GAKSAHTLGPTPSRTETLVEETAAESSEDDVVA--- 1159
Query: 395 GRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQN 454
+ + + PG P +A+K T + L + LA +D+ P+ +++ P++
Sbjct: 1160 -PSQSLLSGYMTPGLTPANS-QASKATPK-LDSSPSVSSTLAAKDD-PDGKQEAKPQQAA 1215
Query: 455 SPVAP-TAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQ 492
++P T +A TPQ P A ST A Q
Sbjct: 1216 GMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQ 1254
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 52.0 bits (123), Expect = 3e-06
Identities = 117/534 (21%), Positives = 183/534 (34%), Gaps = 101/534 (18%)
Query: 4 RKGP-PGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVG--GQPPALE 60
RKG P PP + AA Q+ + E ++ E L A A V G+ P ++
Sbjct: 448 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK 507
Query: 61 KL---------KGKGPLPMEAIEKMASLCM-----RDPDEDEEEGTDEDDLEADDDLLAE 106
KG GP+P + D + EE +D D E +
Sbjct: 508 PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA 567
Query: 107 LNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRY 166
+ LG +A T P P +A ++ ++ + ES+ ++ DSA
Sbjct: 568 QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPM----DNSESSEESSDSADS--- 620
Query: 167 DRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRV 226
E A++ A IP A P T T + A P AP
Sbjct: 621 -------EEAPAAMTAAQAKPALKIPQTKAC---PKKTNTTASAKVAPVRVGTQAPRKAG 670
Query: 227 TLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARH 286
T P+ ++PA + G +P A+ S + + + + T A
Sbjct: 671 TATSPAGSSPAVAGGTQRP------------AEDSSSSEE-------SDSEEEKTGLAVT 711
Query: 287 FRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPR 346
AKS L+ + PV S LP T P+ T+V +
Sbjct: 712 VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK------------TGPTVTQVKAEKQ 759
Query: 347 TLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKA-------GRAVD 399
E+ E+ + + AA+ A+ K +K + K A RA A G+ V
Sbjct: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQ-----AKANPAAARAPSAKGTISAPGKVVT 814
Query: 400 VA----ELPVPPGFPPIQGLE---------ATKPTQQSLVGVLETAMKLANQDEGPEDEE 446
A + PP++ + A+ P+ V A +D G +EE
Sbjct: 815 AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE 874
Query: 447 DEVPKK-----QNSPVAPTAQPKA---PPSRTPQSGSAPTAKAPPKATSTRAQQ 492
+ ++ Q P T Q +A P +P+ G+APT PP T A Q
Sbjct: 875 SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT---PPGKTGPSAAQ 925
Score = 48.9 bits (115), Expect = 2e-05
Identities = 121/536 (22%), Positives = 179/536 (33%), Gaps = 86/536 (16%)
Query: 8 PGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLAL----------VGG-QP 56
P PPG+ A A Q E ++EE A L VG
Sbjct: 317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 57 PALEK-LKGKGPLPM----EAIEK-MASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEV 110
PA E KG P P A+ K A D EE E++ A + +V
Sbjct: 377 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436
Query: 111 LGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGL 170
A E+P A P P P Q ++ + S+ + DS DR
Sbjct: 437 RAASAPAKESPRKGAAPAP--PRKTGPAAAQVQVGKQEEDSRSSSEESDS------DREA 488
Query: 171 KTLENL--LASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRI--------AS 220
N + + K + A +GKG P P P+ ++ +S
Sbjct: 489 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 548
Query: 221 APEPRVTLEG--PSATAPASSPGL-----AKPQMPPG---PCSPGPLAQLQSRQRDYKLA 270
+ E + +G P+A APA L AKP P P GP+A
Sbjct: 549 SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVA-----------V 597
Query: 271 ALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPP 330
+ A++ D + ++ +S D+ A S P ++ P P + P +
Sbjct: 598 QVKAEKPMDNSESSE-----ESSDS---ADSEEAPAAMTAAQAKPALKIPQTKACPKKTN 649
Query: 331 TPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIR 390
T A+A +V P + ++ A + G QR A E +
Sbjct: 650 TTASA----KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA---EDSSSSEESDSE 702
Query: 391 AHKAGRAVDVAE-------LPVPPGFPPIQGL--EATKPTQQSLVGVLETAMKLANQD-- 439
K G AV V + L V P++G + T P G T +K Q+
Sbjct: 703 EEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDS 762
Query: 440 EGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAK----APPKATSTRAQ 491
E E+E D + T+ K P + AP+AK AP K + AQ
Sbjct: 763 ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 818
Score = 43.5 bits (101), Expect = 0.001
Identities = 101/504 (20%), Positives = 173/504 (34%), Gaps = 99/504 (19%)
Query: 87 DEEEGTDEDDLEADDDLLAELNEVLGEE------QKASETPPPVAQPKPEAPHPGLETTL 140
+EEE + + +A L + + VLG + +KA + PHP T+
Sbjct: 89 EEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTV 148
Query: 141 QERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKG 200
L+ G S + TL + A A P V+ G+
Sbjct: 149 ANLLS------------GKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQA 196
Query: 201 PASTPTYSPAPTQ------PAPRIASAPEPRVTLEGPSATAPASSPGLA---KPQMPPGP 251
+S+ S + + P+ + A V+ + A A +PG PQ+ G
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGA 256
Query: 252 CSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVD---- 307
P A+ + + ++++ ++ K+ + +L+ + P
Sbjct: 257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ----VKASEKILQVRAASAPAKGTPG 312
Query: 308 LSCLPPPP-------DQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQ 360
P PP Q P S+ + ++ S E P + LL+A + + Q
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAA-KALLQA-KASGKTSQ 370
Query: 361 VAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGF--PPIQGLEAT 418
V AA A +K RK P PPG P + +A
Sbjct: 371 VGAASAPAKESPRKGAA--------------------------PAPPGKTGPAVAKAQAG 404
Query: 419 KPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPT 478
K + S ++ +E +EE K + AP +P+ G+AP
Sbjct: 405 KREEDSQ----------SSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAP- 453
Query: 479 AKAPPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAK--GLEPMLE- 535
APP+ T A Q G++++ +++ + A M+ Q K G P ++
Sbjct: 454 --APPRKTGPAAAQVQV---GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKP 508
Query: 536 ASRNGL--------PVDITKVPPA 551
AS G+ PV KV PA
Sbjct: 509 ASTMGMGPLGKGAGPVPPGKVGPA 532
Score = 39.7 bits (91), Expect = 0.014
Identities = 97/456 (21%), Positives = 156/456 (34%), Gaps = 109/456 (23%)
Query: 83 DPDEDEEEGTDEDD---------LEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPH 133
+ E EEG++ ++ ++A + +L +V A TP A P P
Sbjct: 268 EESESSEEGSESEEEAPAGTRSQVKASEKIL----QVRAASAPAKGTPGKGATPAP---- 319
Query: 134 PGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPP 193
PG + + + +S + +S+ K L AS K + + A P
Sbjct: 320 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS-GKTSQVGAASAPA 378
Query: 194 PVAIGKGPASTPTYSPAP-------------TQPAPRIASAPEPRVTLEGPSATAP---- 236
+ KG A P P +Q + + + E PS AP
Sbjct: 379 KESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 237 ASSPGLAKPQMPPGPCSP---GPLA---QLQSRQRDYKLAALHAKQQGDTTAAARHFRV- 289
AS+P P+ P P GP A Q+ ++ D + ++ + + AA +V
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 290 --AKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPP-------SQPPTPATAPSTT- 339
KS + P+ P PP ++ P PS S+ + ++ S+
Sbjct: 499 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 340 EVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVD 399
EVP VA AQ KS G+ +A+
Sbjct: 559 EVPTA----------------VAPAQEKSLGNILQAK----------------------- 579
Query: 400 VAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAP 459
P P +G P + V V A K + E E+ D ++ +P A
Sbjct: 580 -------PTSSPAKG----PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE-APAAM 627
Query: 460 TAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLA 495
TA P + PQ+ KA PK T+T A ++A
Sbjct: 628 TAAQAKPALKIPQT------KACPKKTNTTASAKVA 657
>gi|146134388 YLP motif containing 1 [Homo sapiens]
Length = 2146
Score = 52.0 bits (123), Expect = 3e-06
Identities = 75/327 (22%), Positives = 108/327 (33%), Gaps = 66/327 (20%)
Query: 231 PSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVA 290
P P G +P PP P PGP Q +Q+ YK LH ++ G
Sbjct: 88 PPPVMPGGGYGDWQPPPPPMPPPPGPALSYQ-KQQQYKHQMLHHQRDGPPGLVPME---- 142
Query: 291 KSFDAVLEALSRGEPVDL-SCLPPPPDQLPPDPPSPPSQPPT------PATAPSTTEVPP 343
LE+ PV S +PP +PP P P PPT P PS ++ PP
Sbjct: 143 ------LESPPESPPVPPGSYMPPSQSYMPPPQPPPSYYPPTSSQPYLPPAQPSPSQSPP 196
Query: 344 PPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAEL 403
L + + S Q + + Q + G +
Sbjct: 197 SQSYLA----------PTPSYSSSSSSSQSYLSHSQSYLPSSQASPSRPSQGHSKSQLLA 246
Query: 404 PVPPGFP----------PIQGLEATKPTQQS------------------------LVGVL 429
P PP P P++ K T+Q L+ +
Sbjct: 247 PPPPSAPPGNKTTVQQEPLESGAKNKSTEQQQAAPEPDPSTMTPQEQQQYWYRQHLLSLQ 306
Query: 430 E-TAMKLANQDEGPEDEED-EVPKKQNSPVAPTAQ-PKAPPSRTPQSGSAPTAKAPPKAT 486
+ T + L +GP +D P K+ V T+Q P++P S P P + PP
Sbjct: 307 QRTKVHLPGHKKGPVVAKDTPEPVKEEVTVPATSQVPESPSSEEPPL-PPPNEEVPPPLP 365
Query: 487 STRAQQQLAFLEGRKKQLLQAALRAKQ 513
Q + + R KQL AA +Q
Sbjct: 366 PEEPQSEDPEEDARLKQLQAAAAHWQQ 392
Score = 42.0 bits (97), Expect = 0.003
Identities = 64/280 (22%), Positives = 97/280 (34%), Gaps = 56/280 (20%)
Query: 106 ELNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAI-------ESARQAG 158
+L ++L + Q+ + PP + + E Q+ LYQ E
Sbjct: 411 QLQQILQQYQQIIQPPPHIQTMSVDMQLRHYEMQQQQFQHLYQEWEREFQLWEEQLHSYP 470
Query: 159 DSAKMRRYDRGLKTLENLLASIR-------------KGNAIDEADIPPP-VAIGKGPAST 204
+++ Y++ KT + + + + K + +PPP V + P
Sbjct: 471 HKDQLQEYEKQWKTWQGHMKATQSYLQEKVNSFQNMKNQYMGNMSMPPPFVPYSQMPP-- 528
Query: 205 PTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPG-PCS---PGPLAQL 260
P PT P P + + P V AT P PG+ P MPP P S PG L
Sbjct: 529 ----PLPTMPPPVLPPSLPPPVMPPALPATVPP--PGMPPPVMPPSLPTSVPPPGMPPSL 582
Query: 261 QSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPP-----PP 315
S L G +LS P + LPP PP
Sbjct: 583 SSAGPPPVLPPPSLSSAGPPPVLPP------------PSLSSTAPPPVMPLPPLSSATPP 630
Query: 316 DQLPPD------PPSPPSQPPTPATAPSTTEVPPPPRTLL 349
+PP PP + P PA++ +++VP PR L
Sbjct: 631 PGIPPPGVPQGIPPQLTAAPVPPASSSQSSQVPEKPRPAL 670
Score = 41.6 bits (96), Expect = 0.004
Identities = 47/190 (24%), Positives = 64/190 (33%), Gaps = 42/190 (22%)
Query: 313 PPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQ 372
PPP PP P + P P P + STT P + EQ + + Q
Sbjct: 15 PPPPVPPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQL------------Q 62
Query: 373 RKARMHERIVKQYQDAIRAH-------------KAGRAVDVAELPVPPGFPPIQGLEATK 419
+ +MH+ KQ Q ++ H G D P PP PP G +
Sbjct: 63 QLQQMHQ---KQMQCVLQPHHLPPPPLPPPPVMPGGGYGDWQ--PPPPPMPPPPGPALSY 117
Query: 420 PTQQSLVGVLETAMKLANQDEGPE-------DEEDEVPKKQNSPVAPTAQPKAPPSRTPQ 472
QQ L +Q +GP + E P P +Q PP + P
Sbjct: 118 QKQQQY-----KHQMLHHQRDGPPGLVPMELESPPESPPVPPGSYMPPSQSYMPPPQPPP 172
Query: 473 SGSAPTAKAP 482
S PT+ P
Sbjct: 173 SYYPPTSSQP 182
Score = 40.0 bits (92), Expect = 0.010
Identities = 51/215 (23%), Positives = 84/215 (39%), Gaps = 30/215 (13%)
Query: 191 IPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPG 250
+P A P+ + S P P ++ P + T++ + A + + Q P
Sbjct: 225 LPSSQASPSRPSQGHSKSQLLAPPPP--SAPPGNKTTVQQEPLESGAKNKSTEQQQAAPE 282
Query: 251 PCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSC 310
P P + + +Q Y+ L +Q+ H K V A EPV
Sbjct: 283 P-DPSTMTPQEQQQYWYRQHLLSLQQRTKV-----HLPGHKKGPVV--AKDTPEPVKEEV 334
Query: 311 LPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPP-----PRTLLEALEQRMERYQVAAAQ 365
P Q+P P S +PP P P EVPPP P++ + R+++ Q AAA
Sbjct: 335 TVPATSQVPESPSS--EEPPLP---PPNEEVPPPLPPEEPQSEDPEEDARLKQLQAAAAH 389
Query: 366 AKS----------KGDQRKARMHERIVKQYQDAIR 390
+ +G +K ++I++QYQ I+
Sbjct: 390 WQQHQQHRVGFQYQGIMQKHTQLQQILQQYQQIIQ 424
Score = 38.9 bits (89), Expect = 0.023
Identities = 56/249 (22%), Positives = 79/249 (31%), Gaps = 53/249 (21%)
Query: 248 PPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFD----AVLEALSRG 303
PP P P P L A+ TT AA SF A L+ L +
Sbjct: 15 PPPPVPPPPPVALPE-------ASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQM 67
Query: 304 EPVDLSCLPPPPDQLPPDPPSPPSQP--PTPATAPSTTEVPPPPRTLLEALEQRMERYQV 361
+ C+ P PP P PP P P +PPPP L +Q+ ++Q+
Sbjct: 68 HQKQMQCVLQPHHLPPPPLPPPPVMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQM 127
Query: 362 AAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPT 421
H+R + EL PP PP+ P+
Sbjct: 128 L--------------HHQR------------DGPPGLVPMELESPPESPPVPPGSYMPPS 161
Query: 422 QQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKA 481
Q + P+ P + P P AQP S QS APT
Sbjct: 162 QSYM--------------PPPQPPPSYYPPTSSQPYLPPAQPSPSQSPPSQSYLAPTPSY 207
Query: 482 PPKATSTRA 490
++S+++
Sbjct: 208 SSSSSSSQS 216
Score = 37.7 bits (86), Expect = 0.051
Identities = 60/293 (20%), Positives = 98/293 (33%), Gaps = 56/293 (19%)
Query: 188 EADIPP---PVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAK 244
+ D PP P+ + P S P + P+ P+P PS P SS +
Sbjct: 131 QRDGPPGLVPMELESPPESPPVPPGSYMPPSQSYMPPPQPP-----PSYYPPTSS----Q 181
Query: 245 PQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFR-VAKSFDAVLEALSRG 303
P +PP SP +Q Q ++ + + H + S A S+G
Sbjct: 182 PYLPPAQPSP---SQSPPSQSYLAPTPSYSSSSSSSQSYLSHSQSYLPSSQASPSRPSQG 238
Query: 304 EPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTE----VPPPPRTLLEALEQRMERY 359
PPPP P + + +P +TE P P + + EQ+ Y
Sbjct: 239 HSKSQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSTEQQQAAPEPDPSTMTPQEQQQYWY 298
Query: 360 QVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATK 419
+ Q++ ++H + HK G P+ + +
Sbjct: 299 RQHLLSL-----QQRTKVH----------LPGHKKG---------------PVVAKDTPE 328
Query: 420 PTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQ 472
P ++ + T + E P EE +P N V P P+ P S P+
Sbjct: 329 PVKEEV-----TVPATSQVPESPSSEEPPLP-PPNEEVPPPLPPEEPQSEDPE 375
Score = 37.7 bits (86), Expect = 0.051
Identities = 51/226 (22%), Positives = 85/226 (37%), Gaps = 17/226 (7%)
Query: 123 PVAQPKPEAPHP----GLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLA 178
P+A+ P + H G + +L L + S RQ K + + L+ + L
Sbjct: 1415 PMAEHMPSSHHSSEMMGSDASLDSDQGLGGVMVLSQRQHEIILKAAQELKMLREQKEQLQ 1474
Query: 179 SIRK-GNAIDEAD-IPPPVAIGKGPASTPTYSPAPT--QPAPRIASAPEPRVTLEGPSA- 233
++ G+ AD +PP + + +S P P P +P P + P V P A
Sbjct: 1475 KMKDFGSEPQMADHLPPQESRLQNTSSRPGMYPPPGSYRPPPPMGKPPGSIVRPSAPPAR 1534
Query: 234 -TAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKS 292
+ P + P + P PP P P P ++ + A + D+ +
Sbjct: 1535 SSVPVTRPPVPIPPPPPPPPLPPPPPVIKPQTS----AVEQERWDEDSFYGLWDTNDEQG 1590
Query: 293 FDAVLEALSRGEPVDLSCLPPPP--DQLPPDPPSPPSQPPTPATAP 336
++ ++ + P LPPPP +PP P P PP P
Sbjct: 1591 LNSEFKSETAAIP-SAPVLPPPPVHSSIPPPGPVPMGMPPMSKPPP 1635
Score = 36.6 bits (83), Expect = 0.11
Identities = 14/28 (50%), Positives = 16/28 (57%)
Query: 314 PPDQLPPDPPSPPSQPPTPATAPSTTEV 341
PP +PP PP PP PP P P T+ V
Sbjct: 1542 PPVPIPPPPPPPPLPPPPPVIKPQTSAV 1569
Score = 35.0 bits (79), Expect = 0.33
Identities = 16/38 (42%), Positives = 19/38 (50%), Gaps = 4/38 (10%)
Query: 312 PPPPDQLPPD----PPSPPSQPPTPATAPSTTEVPPPP 345
PPPP PP P +PP++ P T P PPPP
Sbjct: 1514 PPPPMGKPPGSIVRPSAPPARSSVPVTRPPVPIPPPPP 1551
Score = 34.3 bits (77), Expect = 0.57
Identities = 46/171 (26%), Positives = 65/171 (38%), Gaps = 21/171 (12%)
Query: 192 PPPVAIGKGPASTPTYSPAPTQPAPRIAS-APEPRVTLEGPSATAPASSPGLAKPQMPPG 250
PPPV P S + P P P P ++S AP P + L S+ P PG+ P +P G
Sbjct: 587 PPPVL---PPPSLSSAGPPPVLPPPSLSSTAPPPVMPLPPLSSATP--PPGIPPPGVPQG 641
Query: 251 --------PCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSR 302
P P +Q S+ + AL +A + E ++
Sbjct: 642 IPPQLTAAPVPPASSSQ-SSQVPEKPRPALLPTPVSFGSAPPTTYHPPLQSAGPSEQVNS 700
Query: 303 GEPVDLSCLPP---PPDQLPPDPPSPPSQPPTPA---TAPSTTEVPPPPRT 347
P+ S LP DQ + + PSQP T S +P PPR+
Sbjct: 701 KAPLSKSALPYSSFSSDQGLGESSAAPSQPITAVKDMPVRSGGLLPDPPRS 751
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,999,049
Number of Sequences: 37866
Number of extensions: 2776211
Number of successful extensions: 49604
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 457
Number of HSP's successfully gapped in prelim test: 1339
Number of HSP's that attempted gapping in prelim test: 23130
Number of HSP's gapped (non-prelim): 17219
length of query: 951
length of database: 18,247,518
effective HSP length: 112
effective length of query: 839
effective length of database: 14,006,526
effective search space: 11751475314
effective search space used: 11751475314
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.