Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 95089461
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|95089461 discs large homolog 5 [Homo sapiens]
(1919 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|95089461 discs large homolog 5 [Homo sapiens] 3809 0.0
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 219 2e-56
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 212 3e-54
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 192 3e-48
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 192 3e-48
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 192 3e-48
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 189 2e-47
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 172 2e-42
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 172 2e-42
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 172 4e-42
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 150 1e-35
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 150 1e-35
gi|10092691 tight junction protein 3 [Homo sapiens] 149 3e-35
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 140 9e-33
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ... 140 9e-33
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 129 3e-29
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 103 1e-21
gi|31982906 cingulin-like 1 [Homo sapiens] 94 2e-18
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 88 9e-17
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 85 6e-16
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 84 1e-15
gi|148746195 trichohyalin [Homo sapiens] 81 1e-14
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 81 1e-14
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 81 1e-14
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 81 1e-14
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 81 1e-14
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 80 1e-14
gi|16262452 cingulin [Homo sapiens] 80 2e-14
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 79 4e-14
gi|50083279 centrosome protein 4 [Homo sapiens] 79 6e-14
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 3809 bits (9878), Expect = 0.0
Identities = 1919/1919 (100%), Positives = 1919/1919 (100%)
Query: 1 MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLDEEAGGAKAELLLKLL 60
MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLDEEAGGAKAELLLKLL
Sbjct: 1 MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLDEEAGGAKAELLLKLL 60
Query: 61 LAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSS 120
LAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSS
Sbjct: 61 LAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSS 120
Query: 121 LSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRP 180
LSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRP
Sbjct: 121 LSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRP 180
Query: 181 YHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRL 240
YHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRL
Sbjct: 181 YHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRL 240
Query: 241 KDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILN 300
KDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILN
Sbjct: 241 KDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILN 300
Query: 301 KLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRD 360
KLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRD
Sbjct: 301 KLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRD 360
Query: 361 TAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEK 420
TAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEK
Sbjct: 361 TAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEK 420
Query: 421 YREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQI 480
YREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQI
Sbjct: 421 YREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQI 480
Query: 481 KDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSI 540
KDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSI
Sbjct: 481 KDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSI 540
Query: 541 RTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLM 600
RTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLM
Sbjct: 541 RTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLM 600
Query: 601 AHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVD 660
AHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVD
Sbjct: 601 AHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVD 660
Query: 661 KGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL 720
KGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL
Sbjct: 661 KGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL 720
Query: 721 HINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESL 780
HINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESL
Sbjct: 721 HINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESL 780
Query: 781 LRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNN 840
LRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNN
Sbjct: 781 LRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNN 840
Query: 841 STQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDAS 900
STQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDAS
Sbjct: 841 STQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDAS 900
Query: 901 GDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEK 960
GDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEK
Sbjct: 901 GDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEK 960
Query: 961 LSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSD 1020
LSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSD
Sbjct: 961 LSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSD 1020
Query: 1021 SIKFQHRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPE 1080
SIKFQHRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPE
Sbjct: 1021 SIKFQHRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPE 1080
Query: 1081 GDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVP 1140
GDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVP
Sbjct: 1081 GDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVP 1140
Query: 1141 ASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVR 1200
ASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVR
Sbjct: 1141 ASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVR 1200
Query: 1201 SHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSAR 1260
SHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSAR
Sbjct: 1201 SHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSAR 1260
Query: 1261 LGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQT 1320
LGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQT
Sbjct: 1261 LGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQT 1320
Query: 1321 SASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVG 1380
SASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVG
Sbjct: 1321 SASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVG 1380
Query: 1381 SIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRS 1440
SIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRS
Sbjct: 1381 SIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRS 1440
Query: 1441 SSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEP 1500
SSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEP
Sbjct: 1441 SSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEP 1500
Query: 1501 RVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTV 1560
RVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTV
Sbjct: 1501 RVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTV 1560
Query: 1561 EEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDIL 1620
EEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDIL
Sbjct: 1561 EEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDIL 1620
Query: 1621 YVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTL 1680
YVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTL
Sbjct: 1621 YVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTL 1680
Query: 1681 SAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALR 1740
SAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALR
Sbjct: 1681 SAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALR 1740
Query: 1741 PVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDV 1800
PVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDV
Sbjct: 1741 PVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDV 1800
Query: 1801 TTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDK 1860
TTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDK
Sbjct: 1801 TTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDK 1860
Query: 1861 VTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL 1919
VTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL
Sbjct: 1861 VTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL 1919
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 219 bits (559), Expect = 2e-56
Identities = 169/643 (26%), Positives = 302/643 (46%), Gaps = 93/643 (14%)
Query: 1339 RKDRPYVEEPRHVKVQKGSEPLGISIVSGE-------KGGIYVSKVTVGSIAHQAG-LEY 1390
++ +P E+ +K+ KG + LG SI G IYV+K+ G AH+ G L+
Sbjct: 308 KRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQI 367
Query: 1391 GDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSR---SSSHLDPA 1447
GD+LL N + L T ++A + D + + ++ ++ ++S P
Sbjct: 368 GDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPV 427
Query: 1448 GTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKK 1507
H + TP P+ P+ S + GD ++ T EPR V + +
Sbjct: 428 DNHVSPSSFLGQTPASPARYSPV---------------SKAVLGD-DEITREPRKVVLHR 471
Query: 1508 SQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVE 1566
LG ++ GG + G+F++ + PA L GD I+ S+D+R + E+
Sbjct: 472 GSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAA 531
Query: 1567 MLKPRDGVRLKVQYRPEEFTKAKGLPGD-----------------------SFYIRAL-- 1601
+ V + QYRPEE+++ + D S Y+RAL
Sbjct: 532 LKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFD 591
Query: 1602 YDRLADV---EQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMD 1658
YD+ D Q L+FK DIL+V + W A Q+ + + + G IPSK ++
Sbjct: 592 YDKTKDSGLPSQGLNFKFGDILHVINASDDEW---WQARQVTPDGESDEVGVIPSKRRVE 648
Query: 1659 QEFSRRLSMSEVKDDNSATK----TLSAAARRSFFRRK---HKHKRSGSKDGKDL---LA 1708
++ RL + NS T+ + + +++ F RK +K+K ++ D +
Sbjct: 649 KKERARLKTVKF---NSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVT 705
Query: 1709 LDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCP 1768
+A S+S ++ L+Y+ V + + RPV+ILGP+ D + + L++E P KF C
Sbjct: 706 SNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCV 765
Query: 1769 LEVMK---------------ASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKN 1813
+ S++ +E+ +++ F++ + + H T+V S++E+ EK
Sbjct: 766 PHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKG 825
Query: 1814 RHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAA 1873
+HC+LD++ +AI+RL +YPI IFI KS ++I E + ++T+ +++ FE A
Sbjct: 826 KHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIME------MNKRLTEEQARKTFERA 879
Query: 1874 QKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
KLEQE++ +FT ++QG L I Q+ ++ ++ +W+PA
Sbjct: 880 MKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPA 922
Score = 106 bits (264), Expect = 2e-22
Identities = 67/206 (32%), Positives = 111/206 (53%), Gaps = 23/206 (11%)
Query: 609 IDTDSMEWETEV--VEFERETEDIDLK----ALGFDMAEGVNEPCFPGDCGIFVTKVDKG 662
++TDS+E T V + + E E+I L+ LGF +A G + P D IF+TK+ G
Sbjct: 202 VNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITG 261
Query: 663 SIA--DGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL 720
A DGRLRVND +LR+N+VD+ + +A++AL + + V+RRK + K+ +
Sbjct: 262 GAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKI---M 318
Query: 721 HINL-SGQKDSGISL-----------ENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIA 768
I L G K G S+ +N +Y ++ G A K+G L +GD+++A+N +
Sbjct: 319 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVC 378
Query: 769 LDNKSLNECESLLRSCQDSLTLSLLK 794
L+ + E + L++ D + L + K
Sbjct: 379 LEEVTHEEAVTALKNTSDFVYLKVAK 404
Score = 61.2 bits (147), Expect = 9e-09
Identities = 54/215 (25%), Positives = 89/215 (41%), Gaps = 57/215 (26%)
Query: 633 KALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWLLRINDVDLINKDKKQ 690
K LGF +A GV PGD I+VTK+ +G A DG+L++ D LL +N+V L ++
Sbjct: 327 KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEE 386
Query: 691 AIKALLNGEGAINMVVRRRKS-----------------------------LGGKVVTP-- 719
A+ AL N + + V + S LG +P
Sbjct: 387 AVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPAR 446
Query: 720 ----------------------LHINLSGQKDSGISLENG--VYAAAVLPGSPAAKEGSL 755
LH +G + + E+G ++ + +L G PA G L
Sbjct: 447 YSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL 506
Query: 756 AVGDRIVAINGIALDNKSLNECESLLRSCQDSLTL 790
GDRI+++N + L S + + L++ ++T+
Sbjct: 507 RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI 541
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 212 bits (539), Expect = 3e-54
Identities = 167/633 (26%), Positives = 292/633 (46%), Gaps = 95/633 (15%)
Query: 1339 RKDRPYVEEPRHVKVQKGSEPLGISIVSGE-------KGGIYVSKVTVGSIAHQAG-LEY 1390
++ +P E+ +K+ KG + LG SI G IYV+K+ G AH+ G L+
Sbjct: 308 KRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQI 367
Query: 1391 GDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSR---SSSHLDPA 1447
GD+LL N + L T ++A + D + + ++ ++ ++S P
Sbjct: 368 GDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPV 427
Query: 1448 GTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKK 1507
H + TP P+ P+ S + GD ++ T EPR V + +
Sbjct: 428 DNHVSPSSFLGQTPASPARYSPV---------------SKAVLGD-DEITREPRKVVLHR 471
Query: 1508 SQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVE 1566
LG ++ GG + G+F++ + PA L GD I+ S+D+R + E+
Sbjct: 472 GSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAA 531
Query: 1567 MLKPRDGVRLKVQYRPEEFTKAKGLPGD-----------------------SFYIRAL-- 1601
+ V + QYRPEE+++ + D S Y+RAL
Sbjct: 532 LKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFD 591
Query: 1602 YDRLADV---EQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMD 1658
YD+ D Q L+FK DIL+V + W A Q+ + + + G IPSK ++
Sbjct: 592 YDKTKDSGLPSQGLNFKFGDILHVINASDDEW---WQARQVTPDGESDEVGVIPSKRRVE 648
Query: 1659 QEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIP 1718
++ RL + NS T+ GSK K + + +A S+S
Sbjct: 649 KKERARLKTVKF---NSKTRDKGEIP-----------DDMGSKGLKHVTS-NASDSESSY 693
Query: 1719 LFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMK----- 1773
++ L+Y+ V + + RPV+ILGP+ D + + L++E P KF C +
Sbjct: 694 RGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDY 753
Query: 1774 ----------ASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPH 1823
S++ +E+ +++ F++ + + H T+V S++E+ EK +HC+LD++ +
Sbjct: 754 EVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGN 813
Query: 1824 AIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRY 1883
AI+RL +YPI IFI KS ++I E + ++T+ +++ FE A KLEQE++ +
Sbjct: 814 AIKRLQIAQLYPISIFIKPKSMENIME------MNKRLTEEQARKTFERAMKLEQEFTEH 867
Query: 1884 FTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
FT ++QG L I Q+ ++ ++ +W+PA
Sbjct: 868 FTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPA 900
Score = 106 bits (264), Expect = 2e-22
Identities = 67/206 (32%), Positives = 111/206 (53%), Gaps = 23/206 (11%)
Query: 609 IDTDSMEWETEV--VEFERETEDIDLK----ALGFDMAEGVNEPCFPGDCGIFVTKVDKG 662
++TDS+E T V + + E E+I L+ LGF +A G + P D IF+TK+ G
Sbjct: 202 VNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITG 261
Query: 663 SIA--DGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL 720
A DGRLRVND +LR+N+VD+ + +A++AL + + V+RRK + K+ +
Sbjct: 262 GAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKI---M 318
Query: 721 HINL-SGQKDSGISL-----------ENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIA 768
I L G K G S+ +N +Y ++ G A K+G L +GD+++A+N +
Sbjct: 319 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVC 378
Query: 769 LDNKSLNECESLLRSCQDSLTLSLLK 794
L+ + E + L++ D + L + K
Sbjct: 379 LEEVTHEEAVTALKNTSDFVYLKVAK 404
Score = 61.2 bits (147), Expect = 9e-09
Identities = 54/215 (25%), Positives = 89/215 (41%), Gaps = 57/215 (26%)
Query: 633 KALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWLLRINDVDLINKDKKQ 690
K LGF +A GV PGD I+VTK+ +G A DG+L++ D LL +N+V L ++
Sbjct: 327 KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEE 386
Query: 691 AIKALLNGEGAINMVVRRRKS-----------------------------LGGKVVTP-- 719
A+ AL N + + V + S LG +P
Sbjct: 387 AVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPAR 446
Query: 720 ----------------------LHINLSGQKDSGISLENG--VYAAAVLPGSPAAKEGSL 755
LH +G + + E+G ++ + +L G PA G L
Sbjct: 447 YSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL 506
Query: 756 AVGDRIVAINGIALDNKSLNECESLLRSCQDSLTL 790
GDRI+++N + L S + + L++ ++T+
Sbjct: 507 RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI 541
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapiens]
Length = 767
Score = 192 bits (488), Expect = 3e-48
Identities = 160/636 (25%), Positives = 279/636 (43%), Gaps = 128/636 (20%)
Query: 1342 RPYVEEPRHVKVQKGSEPLGISIVSGE-------KGGIYVSKVTVGSIAHQAG-LEYGDQ 1393
+P E+ +K+ KG + LG SI G IYV+K+ G AH+ G L+ GD+
Sbjct: 195 KPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 254
Query: 1394 LLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRS------SSHLDPA 1447
+L N + L + A + D + + + + S++ S HLD
Sbjct: 255 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 314
Query: 1448 GTHSTLQGSG---TTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVF 1504
+HS+ G+ TP P P+ + G P EPR +
Sbjct: 315 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR----------------EPRRIV 358
Query: 1505 IKKSQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEV 1563
I + LG ++ GG + G+F++ + PA L GD IL +D+RN + E+
Sbjct: 359 IHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 418
Query: 1564 YVEMLKPRDGVRLKVQYRPEEFTK-----------------------AKGLPGDSFYIRA 1600
+ + V + QY+PEE+++ + P FYIRA
Sbjct: 419 AIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRA 478
Query: 1601 L--YDRLAD---VEQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKY 1655
L YD+ D + Q LSF+ D+L+V D + W A ++ +++ G IPSK
Sbjct: 479 LFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEW---WQARRVHSDSETDDIGFIPSK- 534
Query: 1656 VMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSD 1715
RR+ RR + R K K D SS
Sbjct: 535 -------RRVE------------------RREWSRLKAK---------------DWGSSS 554
Query: 1716 SIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMK-- 1773
EDSV L+Y+ V +++ RP++ILGP D + L++E P KF C +
Sbjct: 555 GSQGREDSV-LSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPK 613
Query: 1774 -------------ASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDI 1820
+S++ +E+ ++ F++ + + H T+V S++E+ E+ +HC+LD+
Sbjct: 614 REYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDV 673
Query: 1821 APHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEY 1880
+ +A+ RL H++PI IFI +S +++ E + ++T+ +++ F+ A KLEQE+
Sbjct: 674 SANAVRRLQAAHLHPIAIFIRPRSLENVLE------INKRITEEQARKAFDRATKLEQEF 727
Query: 1881 SRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
+ F+ +++G + I ++ ++ +W+PA
Sbjct: 728 TECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPA 763
Score = 96.3 bits (238), Expect = 3e-19
Identities = 76/260 (29%), Positives = 127/260 (48%), Gaps = 41/260 (15%)
Query: 573 NDVSRELKELKEQMESQLEKEARFRQL------MAHS---------SHDSAIDTDSME-- 615
+D+ + L ++ + E+ L + ++R + HS S ++TD++E
Sbjct: 32 SDLFQALLDILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAP 91
Query: 616 -WETEV--VEFERETEDIDLK----ALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--D 666
+E +V E E E E+I L+ LGF +A G + P D IF+TK+ G A D
Sbjct: 92 GYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQD 151
Query: 667 GRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINL-S 725
GRLRVND +L +N+VD+ A++AL + + V RRK KV + I L
Sbjct: 152 GRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKV---MEIKLIK 208
Query: 726 GQKDSGISL-----------ENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSL 774
G K G S+ +N +Y ++ G A K+G L +GD+I+A+N + L++
Sbjct: 209 GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMH 268
Query: 775 NECESLLRSCQDSLTLSLLK 794
+ + L++ D + L + K
Sbjct: 269 EDAVAALKNTYDVVYLKVAK 288
Score = 42.0 bits (97), Expect = 0.006
Identities = 22/73 (30%), Positives = 39/73 (53%), Gaps = 5/73 (6%)
Query: 718 TPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNEC 777
T L N+ G +D G++ + +L G PA G L GD+I+++NG+ L N S +
Sbjct: 364 TGLGFNIVGGEDG-----EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 418
Query: 778 ESLLRSCQDSLTL 790
L++ ++T+
Sbjct: 419 AIALKNAGQTVTI 431
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 192 bits (488), Expect = 3e-48
Identities = 160/636 (25%), Positives = 279/636 (43%), Gaps = 128/636 (20%)
Query: 1342 RPYVEEPRHVKVQKGSEPLGISIVSGE-------KGGIYVSKVTVGSIAHQAG-LEYGDQ 1393
+P E+ +K+ KG + LG SI G IYV+K+ G AH+ G L+ GD+
Sbjct: 149 KPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 208
Query: 1394 LLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRS------SSHLDPA 1447
+L N + L + A + D + + + + S++ S HLD
Sbjct: 209 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 268
Query: 1448 GTHSTLQGSG---TTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVF 1504
+HS+ G+ TP P P+ + G P EPR +
Sbjct: 269 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR----------------EPRRIV 312
Query: 1505 IKKSQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEV 1563
I + LG ++ GG + G+F++ + PA L GD IL +D+RN + E+
Sbjct: 313 IHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 372
Query: 1564 YVEMLKPRDGVRLKVQYRPEEFTK-----------------------AKGLPGDSFYIRA 1600
+ + V + QY+PEE+++ + P FYIRA
Sbjct: 373 AIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRA 432
Query: 1601 L--YDRLAD---VEQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKY 1655
L YD+ D + Q LSF+ D+L+V D + W A ++ +++ G IPSK
Sbjct: 433 LFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEW---WQARRVHSDSETDDIGFIPSK- 488
Query: 1656 VMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSD 1715
RR+ RR + R K K D SS
Sbjct: 489 -------RRVE------------------RREWSRLKAK---------------DWGSSS 508
Query: 1716 SIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMK-- 1773
EDSV L+Y+ V +++ RP++ILGP D + L++E P KF C +
Sbjct: 509 GSQGREDSV-LSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPK 567
Query: 1774 -------------ASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDI 1820
+S++ +E+ ++ F++ + + H T+V S++E+ E+ +HC+LD+
Sbjct: 568 REYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDV 627
Query: 1821 APHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEY 1880
+ +A+ RL H++PI IFI +S +++ E + ++T+ +++ F+ A KLEQE+
Sbjct: 628 SANAVRRLQAAHLHPIAIFIRPRSLENVLE------INKRITEEQARKAFDRATKLEQEF 681
Query: 1881 SRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
+ F+ +++G + I ++ ++ +W+PA
Sbjct: 682 TECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPA 717
Score = 95.1 bits (235), Expect = 6e-19
Identities = 67/206 (32%), Positives = 105/206 (50%), Gaps = 23/206 (11%)
Query: 609 IDTDSMEWETEV--VEFERETEDIDLK----ALGFDMAEGVNEPCFPGDCGIFVTKVDKG 662
++TD++E V E E E E+I L+ LGF +A G + P D IF+TK+ G
Sbjct: 40 VNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPG 99
Query: 663 SIA--DGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL 720
A DGRLRVND +L +N+VD+ A++AL + + V RRK KV +
Sbjct: 100 GAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKV---M 156
Query: 721 HINL-SGQKDSGISL-----------ENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIA 768
I L G K G S+ +N +Y ++ G A K+G L +GD+I+A+N +
Sbjct: 157 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVG 216
Query: 769 LDNKSLNECESLLRSCQDSLTLSLLK 794
L++ + + L++ D + L + K
Sbjct: 217 LEDVMHEDAVAALKNTYDVVYLKVAK 242
Score = 42.0 bits (97), Expect = 0.006
Identities = 22/73 (30%), Positives = 39/73 (53%), Gaps = 5/73 (6%)
Query: 718 TPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNEC 777
T L N+ G +D G++ + +L G PA G L GD+I+++NG+ L N S +
Sbjct: 318 TGLGFNIVGGEDG-----EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 372
Query: 778 ESLLRSCQDSLTL 790
L++ ++T+
Sbjct: 373 AIALKNAGQTVTI 385
>gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens]
Length = 817
Score = 192 bits (487), Expect = 3e-48
Identities = 163/634 (25%), Positives = 280/634 (44%), Gaps = 91/634 (14%)
Query: 1339 RKDRPYVEEPRHVKVQKGSEPLGISIVSG-------EKGGIYVSKVTVGSIAHQAG-LEY 1390
R+ +P E V + KG + LG SI G IY++K+ G A + G L+
Sbjct: 215 RRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQI 274
Query: 1391 GDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTH 1450
GD+LL N NL+ ++A + D + + +H ++ D A T
Sbjct: 275 GDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPP----DYASTF 330
Query: 1451 STLQG---SGTTTPEHPSVIDPLMEQDEGPSTPPAKQSS-SRIAGDANKKTLEPRVVFIK 1506
+ L S ++ + ++ + P PP + S R T EPR + +
Sbjct: 331 TALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILH 390
Query: 1507 KSQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYV 1565
K LG ++ GG + G+FV+ + PA L GD IL +++RN T E+
Sbjct: 391 KGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAA 450
Query: 1566 EMLKPRDGVRLKVQYRPEEFTKAKGLPGD-----------------------SFYIRAL- 1601
+ + V + QYRPEE+++ + D S Y+RAL
Sbjct: 451 ALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALF 510
Query: 1602 -YDRLADV---EQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVM 1657
YDR D Q LSF DIL+V + W A + + + Q G IPSK +
Sbjct: 511 DYDRTRDSCLPSQGLSFSYGDILHVINASDDEW---WQARLVTPHGESEQIGVIPSKKRV 567
Query: 1658 DQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSI 1717
+++ RL KT+ AR L+ D + + ++
Sbjct: 568 EKKERARL------------KTVKFHARTGMIESNRDFPG---------LSDDYYGAKNL 606
Query: 1718 PLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMK---- 1773
ED++ L+Y+ V + + RPV+ILGP+ D V + L++E P KF C +
Sbjct: 607 KGQEDAI-LSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRD 665
Query: 1774 -----------ASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAP 1822
S++ +E+ ++D F++ + + + T++ S++ + E+ +HC+LD++
Sbjct: 666 NEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSG 725
Query: 1823 HAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSR 1882
+AI+RL +YPI IFI KS + + E + + T + + ++ A KLEQE+
Sbjct: 726 NAIKRLQQAQLYPIAIFIKPKSIEALME------MNRRQTYEQANKIYDKAMKLEQEFGE 779
Query: 1883 YFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
YFT ++QG +L I +I ++ + +W+P+
Sbjct: 780 YFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPS 813
Score = 97.1 bits (240), Expect = 2e-19
Identities = 60/174 (34%), Positives = 93/174 (53%), Gaps = 17/174 (9%)
Query: 635 LGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWLLRINDVDLINKDKKQAI 692
LGF +A G++ P P D GIF+TK+ G A DGRL VND +LR+N+VD+ +A+
Sbjct: 141 LGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAV 200
Query: 693 KALLNGEGAINMVVRRRKSLGGKVVTPLHIN-LSGQKDSGISL-----------ENGVYA 740
+AL + +VVRRR+ T + +N L G K G S+ +N +Y
Sbjct: 201 EALKEAGPVVRLVVRRRQP---PPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYI 257
Query: 741 AAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLK 794
++ G A K+G L +GDR++A+N L + E + L++ D + L + K
Sbjct: 258 TKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAK 311
Score = 54.3 bits (129), Expect = 1e-06
Identities = 29/82 (35%), Positives = 48/82 (58%), Gaps = 2/82 (2%)
Query: 633 KALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWLLRINDVDLINKDKKQ 690
K LGF +A G+ PGD I++TK+ +G A DGRL++ D LL +N+ +L + ++
Sbjct: 234 KGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEE 293
Query: 691 AIKALLNGEGAINMVVRRRKSL 712
A+ +L N + + V + SL
Sbjct: 294 AVASLKNTSDMVYLKVAKPGSL 315
Score = 45.4 bits (106), Expect = 5e-04
Identities = 26/82 (31%), Positives = 43/82 (52%), Gaps = 5/82 (6%)
Query: 709 RKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIA 768
RK + K T L N+ G +D G++ + +L G PA G L GDRI+++NG+
Sbjct: 385 RKIILHKGSTGLGFNIVGGEDG-----EGIFVSFILAGGPADLSGELRRGDRILSVNGVN 439
Query: 769 LDNKSLNECESLLRSCQDSLTL 790
L N + + + L+ S+T+
Sbjct: 440 LRNATHEQAAAALKRAGQSVTI 461
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 189 bits (480), Expect = 2e-47
Identities = 167/647 (25%), Positives = 294/647 (45%), Gaps = 101/647 (15%)
Query: 1339 RKDRPYVEEPRHVKVQKGSEPLGISIVSGE-------KGGIYVSKVTVGSIAHQAG-LEY 1390
R+ RP +E +K+ KG + LG SI G IYV+K+ G A + G L+
Sbjct: 131 RRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQV 190
Query: 1391 GDQLLEFNGINLRSATEQQARLIIGQQCDTI-------TILAQYNPHVHQLSSHSRS--- 1440
GD+LL N +L T ++A I+ + + T + +P+ +HS S
Sbjct: 191 GDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPM 250
Query: 1441 SSHLDPAGTHSTLQGSGTTTPEHPSVIDPL---MEQDEGPSTPPAKQSSSRIAGDANKKT 1497
+HL +G + TL+ + P P P+ M D+ ++ +++R ++
Sbjct: 251 ENHL-LSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRA 309
Query: 1498 L----EPRVVFIKKSQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGS 1552
+ EPR V + K LG ++ GG + G+FV+ + PA L GD IL
Sbjct: 310 VSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNG 369
Query: 1553 LDVRNKTVEEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGD------------------ 1594
+D+R + E+ + V + QY+PE++ + + D
Sbjct: 370 IDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLR 429
Query: 1595 -----SFYIRAL--YDRLADV---EQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQ 1644
S Y+RA+ YD+ D Q LSFK DIL+V + W A ++
Sbjct: 430 TNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGD 486
Query: 1645 KIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGK 1704
+ G IPSK ++++ RL KT+ A+ K G G
Sbjct: 487 SEEMGVIPSKRRVERKERARL------------KTVKFNAKPGVIDSK------GDIPG- 527
Query: 1705 DLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKF 1764
L D + + ++ ED + L+Y+ V + + RPV+ILGP+ D + + L++E P KF
Sbjct: 528 --LGDDGYGTKTLRGQEDLI-LSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKF 584
Query: 1765 CRCPLEVMKA---------------SQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEI 1809
C + S++ +E+ +++ F++ + + + T+V S++ +
Sbjct: 585 GSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFV 644
Query: 1810 TEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQ 1869
E+ +HC+LD++ +AI+RL +YPI IFI +S + + E + ++T+ +K+
Sbjct: 645 AERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME------MNKRLTEEQAKKT 698
Query: 1870 FEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
++ A KLEQE+ YFT ++QG L I Q ++ ++ +WIP+
Sbjct: 699 YDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 745
Score = 100 bits (248), Expect = 2e-20
Identities = 64/191 (33%), Positives = 102/191 (53%), Gaps = 21/191 (10%)
Query: 622 EFERETEDIDLK----ALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWL 675
E E E E+I L+ LGF +A G + P D GIF+TK+ G A DGRLRVND +
Sbjct: 40 EIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 99
Query: 676 LRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINL-SGQKDSGISL 734
LR+N+VD+ +A++AL + + VRRR+ + + T + I L G K G S+
Sbjct: 100 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI---LETVVEIKLFKGPKGLGFSI 156
Query: 735 -----------ENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRS 783
+N +Y ++ G A K+G L VGDR++ +N +L+ + E ++L++
Sbjct: 157 AGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 216
Query: 784 CQDSLTLSLLK 794
+ + L + K
Sbjct: 217 TSEVVYLKVGK 227
Score = 43.1 bits (100), Expect = 0.003
Identities = 26/90 (28%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 701 AINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDR 760
A+++ RK + K T L N+ G +D G++ + +L G PA G L GD+
Sbjct: 309 AVSLEGEPRKVVLHKGSTGLGFNIVGGEDG-----EGIFVSFILAGGPADLSGELQRGDQ 363
Query: 761 IVAINGIALDNKSLNECESLLRSCQDSLTL 790
I+++NGI L S + + L+ ++T+
Sbjct: 364 ILSVNGIDLRGASHEQAAAALKGAGQTVTI 393
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 172 bits (437), Expect = 2e-42
Identities = 172/705 (24%), Positives = 298/705 (42%), Gaps = 147/705 (20%)
Query: 1339 RKDRPYVEEPRHVKVQKGSEPLGISIVSGE-------KGGIYVSKVTVGSIAHQAG-LEY 1390
R+ RP +E +K+ KG + LG SI G IYV+K+ G A + G L+
Sbjct: 287 RRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQV 346
Query: 1391 GDQLLEFNGINLRSATEQQARLIIGQQCDTI-------------------TILAQYNPHV 1431
GD+LL N +L T ++A I+ + + I Y+P +
Sbjct: 347 GDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPM 406
Query: 1432 --HQLSSHSR-----------SSSHLDPAGTHSTLQGSGTTTPEHP-SVIDPLMEQDEGP 1477
H LS ++ S P H + T PE S ++ L ++ P
Sbjct: 407 ENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASP 466
Query: 1478 S------------------------TPPAKQSSSRIAGDANKK---TL--------EPRV 1502
P ++ +S A ++ TL EPR
Sbjct: 467 RHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRK 526
Query: 1503 VFIKKSQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVE 1561
V + K LG ++ GG + G+FV+ + PA L GD IL +D+R + E
Sbjct: 527 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 586
Query: 1562 EVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGD-----------------------SFYI 1598
+ + V + QY+PE++ + + D S Y+
Sbjct: 587 QAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYV 646
Query: 1599 RAL--YDRLADV---EQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPS 1653
RA+ YD+ D Q LSFK DIL+V + W A ++ + G IPS
Sbjct: 647 RAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGDSEEMGVIPS 703
Query: 1654 KYVMDQEFSRRLSMSEVKDDNSATKTLSA---AARRSF-FRRK---HKHKRSGSKDGKDL 1706
K ++++ RL + + + ++SF F RK +K+K ++
Sbjct: 704 KRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQE---- 759
Query: 1707 LALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCR 1766
+SD ED + L+Y+ V + + RPV+ILGP+ D + + L++E P KF
Sbjct: 760 ------TSDPERGQEDLI-LSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGS 812
Query: 1767 CPLEVMKA---------------SQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITE 1811
C + S++ +E+ +++ F++ + + + T+V S++ + E
Sbjct: 813 CVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE 872
Query: 1812 KNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFE 1871
+ +HC+LD++ +AI+RL +YPI IFI +S + + E + ++T+ +K+ ++
Sbjct: 873 RGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME------MNKRLTEEQAKKTYD 926
Query: 1872 AAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
A KLEQE+ YFT ++QG L I Q ++ ++ +WIP+
Sbjct: 927 RAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 971
Score = 103 bits (256), Expect = 2e-21
Identities = 109/415 (26%), Positives = 183/415 (44%), Gaps = 83/415 (20%)
Query: 410 TQVKTAKESEKYREERDAVYSEYKLIMSERDQVISEL-DKLQTEVELAE---SKLKSSTS 465
T + + K E+ EE + V ++ E+ +++ D+LQ EL + SK +S
Sbjct: 22 TLLNSQKSCEQKIEEANQVLQKW-----EKTSLLAPCHDRLQKSSELTDCSGSKENASCI 76
Query: 466 EKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDW 525
E+ N+ E + +T T + GR + C EA V C + +
Sbjct: 77 EQNKENQSFE--NETDETTTQNQGRCPAQ------NCSV------EAPAWMPVHHCTK-Y 121
Query: 526 AFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQ 585
+Q+ D D ++ L +R EL + E+
Sbjct: 122 RYQDEDA-----------------PHDHSLPRLTHEVRG------------PELVHVSEK 152
Query: 586 MESQLEKEARFRQLMAHSSHDSA------IDTDSMEWETEV--VEFERETEDIDLK---- 633
SQ+E + L +H S A ++TD+++ V E E E E+I L+
Sbjct: 153 NLSQIENVHGY-VLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNS 211
Query: 634 ALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWLLRINDVDLINKDKKQA 691
LGF +A G + P D GIF+TK+ G A DGRLRVND +LR+N+VD+ +A
Sbjct: 212 GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKA 271
Query: 692 IKALLNGEGAINMVVRRRKSLGGKVVTPLHINL-SGQKDSGISL-----------ENGVY 739
++AL + + VRRR+ + + T + I L G K G S+ +N +Y
Sbjct: 272 VEALKEAGSIVRLYVRRRRPI---LETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIY 328
Query: 740 AAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLK 794
++ G A K+G L VGDR++ +N +L+ + E ++L++ + + L + K
Sbjct: 329 VTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 383
Score = 43.1 bits (100), Expect = 0.003
Identities = 26/90 (28%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 701 AINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDR 760
A+++ RK + K T L N+ G +D G++ + +L G PA G L GD+
Sbjct: 517 AVSLEGEPRKVVLHKGSTGLGFNIVGGEDG-----EGIFVSFILAGGPADLSGELQRGDQ 571
Query: 761 IVAINGIALDNKSLNECESLLRSCQDSLTL 790
I+++NGI L S + + L+ ++T+
Sbjct: 572 ILSVNGIDLRGASHEQAAAALKGAGQTVTI 601
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 172 bits (437), Expect = 2e-42
Identities = 172/705 (24%), Positives = 298/705 (42%), Gaps = 147/705 (20%)
Query: 1339 RKDRPYVEEPRHVKVQKGSEPLGISIVSGE-------KGGIYVSKVTVGSIAHQAG-LEY 1390
R+ RP +E +K+ KG + LG SI G IYV+K+ G A + G L+
Sbjct: 182 RRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQV 241
Query: 1391 GDQLLEFNGINLRSATEQQARLIIGQQCDTI-------------------TILAQYNPHV 1431
GD+LL N +L T ++A I+ + + I Y+P +
Sbjct: 242 GDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPM 301
Query: 1432 --HQLSSHSR-----------SSSHLDPAGTHSTLQGSGTTTPEHP-SVIDPLMEQDEGP 1477
H LS ++ S P H + T PE S ++ L ++ P
Sbjct: 302 ENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASP 361
Query: 1478 S------------------------TPPAKQSSSRIAGDANKK---TL--------EPRV 1502
P ++ +S A ++ TL EPR
Sbjct: 362 RHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRK 421
Query: 1503 VFIKKSQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVE 1561
V + K LG ++ GG + G+FV+ + PA L GD IL +D+R + E
Sbjct: 422 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 481
Query: 1562 EVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGD-----------------------SFYI 1598
+ + V + QY+PE++ + + D S Y+
Sbjct: 482 QAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYV 541
Query: 1599 RAL--YDRLADV---EQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPS 1653
RA+ YD+ D Q LSFK DIL+V + W A ++ + G IPS
Sbjct: 542 RAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGDSEEMGVIPS 598
Query: 1654 KYVMDQEFSRRLSMSEVKDDNSATKTLSA---AARRSF-FRRK---HKHKRSGSKDGKDL 1706
K ++++ RL + + + ++SF F RK +K+K ++
Sbjct: 599 KRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQE---- 654
Query: 1707 LALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCR 1766
+SD ED + L+Y+ V + + RPV+ILGP+ D + + L++E P KF
Sbjct: 655 ------TSDPERGQEDLI-LSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGS 707
Query: 1767 CPLEVMKA---------------SQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITE 1811
C + S++ +E+ +++ F++ + + + T+V S++ + E
Sbjct: 708 CVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE 767
Query: 1812 KNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFE 1871
+ +HC+LD++ +AI+RL +YPI IFI +S + + E + ++T+ +K+ ++
Sbjct: 768 RGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME------MNKRLTEEQAKKTYD 821
Query: 1872 AAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
A KLEQE+ YFT ++QG L I Q ++ ++ +WIP+
Sbjct: 822 RAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 866
Score = 102 bits (255), Expect = 3e-21
Identities = 77/243 (31%), Positives = 125/243 (51%), Gaps = 30/243 (12%)
Query: 578 ELKELKEQMESQLEKEARFRQLMAHSSHDSA------IDTDSMEWETEV--VEFERETED 629
EL + E+ SQ+E + L +H S A ++TD+++ V E E E E+
Sbjct: 40 ELVHVSEKNLSQIENVHGY-VLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEE 98
Query: 630 IDLK----ALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWLLRINDVDL 683
I L+ LGF +A G + P D GIF+TK+ G A DGRLRVND +LR+N+VD+
Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
Query: 684 INKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINL-SGQKDSGISL-------- 734
+A++AL + + VRRR+ + + T + I L G K G S+
Sbjct: 159 SEVSHSKAVEALKEAGSIVRLYVRRRRPI---LETVVEIKLFKGPKGLGFSIAGGVGNQH 215
Query: 735 ---ENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLS 791
+N +Y ++ G A K+G L VGDR++ +N +L+ + E ++L++ + + L
Sbjct: 216 IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLK 275
Query: 792 LLK 794
+ K
Sbjct: 276 VGK 278
Score = 43.1 bits (100), Expect = 0.003
Identities = 26/90 (28%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 701 AINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDR 760
A+++ RK + K T L N+ G +D G++ + +L G PA G L GD+
Sbjct: 412 AVSLEGEPRKVVLHKGSTGLGFNIVGGEDG-----EGIFVSFILAGGPADLSGELQRGDQ 466
Query: 761 IVAINGIALDNKSLNECESLLRSCQDSLTL 790
I+++NGI L S + + L+ ++T+
Sbjct: 467 ILSVNGIDLRGASHEQAAAALKGAGQTVTI 496
>gi|119943108 synapse-associated protein 102 isoform b [Homo sapiens]
Length = 512
Score = 172 bits (435), Expect = 4e-42
Identities = 132/486 (27%), Positives = 229/486 (47%), Gaps = 69/486 (14%)
Query: 1486 SSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPG 1544
S R GDA EPR + + K LG ++ GG + G+FV+ + PA L G
Sbjct: 37 SLRPGGDAR----EPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRG 92
Query: 1545 DLILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGD---------- 1594
D IL +++RN T E+ + + V + QYRPEE+++ + D
Sbjct: 93 DRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSM 152
Query: 1595 -------------SFYIRAL--YDRLADV---EQELSFKKDDILYVDDTLPQGTFGSWMA 1636
S Y+RAL YDR D Q LSF DIL+V + W A
Sbjct: 153 SSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEW---WQA 209
Query: 1637 WQLDENAQKIQRGQIPSKYVMDQEFSRRL------SMSEVKDDNSATKTLSAAARR---- 1686
+ + + Q G IPSK ++++ RL + + + + N + KT + R
Sbjct: 210 RLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRK 269
Query: 1687 -SFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLIL 1745
F++ K + S + + + + S S ED++ L+Y+ V + + RPV+IL
Sbjct: 270 FPFYKSKENMAQESSIQEQGVTSNTSDSESSSKGQEDAI-LSYEPVTRQEIHYARPVIIL 328
Query: 1746 GPLLDVVKEMLVNEAPGKFCRCPLEVMK---------------ASQQAIERGVKDCLFVD 1790
GP+ D V + L++E P KF C + S++ +E+ ++D F++
Sbjct: 329 GPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIE 388
Query: 1791 YKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKE 1850
+ + + T++ S++ + E+ +HC+LD++ +AI+RL +YPI IFI KS + + E
Sbjct: 389 AGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALME 448
Query: 1851 QRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNK 1910
+ + T + + ++ A KLEQE+ YFT ++QG +L I +I ++ +
Sbjct: 449 ------MNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGH 502
Query: 1911 VLWIPA 1916
+W+P+
Sbjct: 503 YIWVPS 508
Score = 73.2 bits (178), Expect = 2e-12
Identities = 45/116 (38%), Positives = 65/116 (56%), Gaps = 10/116 (8%)
Query: 1347 EPRHVKVQKGSEPLGISIVSGEKG-GIYVSKVTVGSIAHQAG-LEYGDQLLEFNGINLRS 1404
EPR + + KGS LG +IV GE G GI+VS + G A +G L GD++L NG+NLR+
Sbjct: 46 EPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 105
Query: 1405 ATEQQARLIIGQQCDTITILAQYNPH--------VHQLSSHSRSSSHLDPAGTHST 1452
AT +QA + + ++TI+AQY P +H L +SS +G+ T
Sbjct: 106 ATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRT 161
Score = 45.4 bits (106), Expect = 5e-04
Identities = 26/82 (31%), Positives = 43/82 (52%), Gaps = 5/82 (6%)
Query: 709 RKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIA 768
RK + K T L N+ G +D G++ + +L G PA G L GDRI+++NG+
Sbjct: 48 RKIILHKGSTGLGFNIVGGEDG-----EGIFVSFILAGGPADLSGELRRGDRILSVNGVN 102
Query: 769 LDNKSLNECESLLRSCQDSLTL 790
L N + + + L+ S+T+
Sbjct: 103 LRNATHEQAAAALKRAGQSVTI 124
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 150 bits (379), Expect = 1e-35
Identities = 122/424 (28%), Positives = 206/424 (48%), Gaps = 48/424 (11%)
Query: 1498 LEPRVVFIK-KSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVR 1556
L P + +K + +G+ L GGN G+FVA V +DSPA +GL GD IL ++D
Sbjct: 418 LRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPA-AKEGLEEGDQILRVNNVDFT 476
Query: 1557 NKTVEEVYVEMLKPRDG--VRLKVQYRPEEFTK-AKGLPGDSFYIRALYDRLADVEQELS 1613
N EE + +L G V + Q + + + + + GDSFYIR ++ + LS
Sbjct: 477 NIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLS 536
Query: 1614 FKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDD 1673
F K ++ V DTL G GSW+A ++ +N ++++RG IP+K +Q S + ++ +
Sbjct: 537 FNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKT--- 593
Query: 1674 NSATKTLSAAARRSF--FRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRV 1731
+ R F FR KR+ K +DL A P AY+RV
Sbjct: 594 -------AGGDRADFWRFRGLRSSKRNLRKSREDLSAQPV--QTKFP--------AYERV 636
Query: 1732 QKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDY 1791
+ LRPV I GP+ DV +E L E P + E A
Sbjct: 637 VLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTD-------------- 682
Query: 1792 KRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQ 1851
+R SG + + +IK+I ++++H LLD+ P+A++RL++ YPIV+F++ S + +K
Sbjct: 683 QRSSG---IIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTM 739
Query: 1852 RDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQIL-AMVNQEQNK 1910
R + +++ +++ +E + KL + FT I +++ L + Q+QN+
Sbjct: 740 RMRLC---PESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQ 796
Query: 1911 VLWI 1914
++W+
Sbjct: 797 LVWV 800
Score = 50.4 bits (119), Expect = 2e-05
Identities = 60/218 (27%), Positives = 93/218 (42%), Gaps = 19/218 (8%)
Query: 1227 HQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKAERIKIP---STP--- 1280
H GR R+ S + R+ +S S + + S ERI P STP
Sbjct: 299 HSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKH 358
Query: 1281 ---RYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGE 1337
P++V E +V +E TP P + Q P V P S E
Sbjct: 359 ADDHTPKTV---EEVTVERNEKQTP-SLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHE 414
Query: 1338 RRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEF 1397
RP + + VK +KG + +G+ + G GI+V+ V S A + GLE GDQ+L
Sbjct: 415 DGILRPSM---KLVKFRKG-DSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRV 470
Query: 1398 NGINLRSATEQQARLIIGQ--QCDTITILAQYNPHVHQ 1433
N ++ + ++A L + + + +TILAQ V++
Sbjct: 471 NNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYR 508
Score = 39.3 bits (90), Expect = 0.037
Identities = 32/122 (26%), Positives = 55/122 (45%), Gaps = 9/122 (7%)
Query: 603 SSHDSAIDTDSME----WETEVVEFERETEDIDLKALGFDMAEGVNEPCFP-GDCGIFVT 657
S+ +A + +ME WE V R G ++ G + P F G+ I ++
Sbjct: 2 SARAAAAKSTAMEETAIWEQHTVTLHRAPGF----GFGIAISGGRDNPHFQSGETSIVIS 57
Query: 658 KVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVV 717
V KG A+G+L+ ND + +N V + N + A++ L + +RR+K + V
Sbjct: 58 DVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVS 117
Query: 718 TP 719
P
Sbjct: 118 RP 119
Score = 34.7 bits (78), Expect = 0.92
Identities = 17/35 (48%), Positives = 23/35 (65%), Gaps = 1/35 (2%)
Query: 737 GVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDN 771
G++ A VL SPAAKEG L GD+I+ +N + N
Sbjct: 444 GIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTN 477
Score = 34.3 bits (77), Expect = 1.2
Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 4/52 (7%)
Query: 722 INLSGQKDSGI--SLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDN 771
I +SG +D+ S E + + VL G PA EG L DR+ +NG+++DN
Sbjct: 36 IAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDN 85
Score = 33.1 bits (74), Expect = 2.7
Identities = 33/123 (26%), Positives = 64/123 (52%), Gaps = 22/123 (17%)
Query: 599 LMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTK 658
++ +S+H+ I SM+ +V+F R+ + + L+ G + D GIFV
Sbjct: 407 VLPNSTHEDGILRPSMK----LVKF-RKGDSVGLRLAGGN------------DVGIFVAG 449
Query: 659 VDKGS-IADGRLRVNDWLLRINDVDLINKDKKQAIKALLN---GEGAINMVVRRRKSLGG 714
V + S A L D +LR+N+VD N +++A+ LL+ GE + ++ +++K +
Sbjct: 450 VLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGE-EVTILAQKKKDVYR 508
Query: 715 KVV 717
++V
Sbjct: 509 RIV 511
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 150 bits (379), Expect = 1e-35
Identities = 122/424 (28%), Positives = 206/424 (48%), Gaps = 48/424 (11%)
Query: 1498 LEPRVVFIK-KSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVR 1556
L P + +K + +G+ L GGN G+FVA V +DSPA +GL GD IL ++D
Sbjct: 418 LRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPA-AKEGLEEGDQILRVNNVDFT 476
Query: 1557 NKTVEEVYVEMLKPRDG--VRLKVQYRPEEFTK-AKGLPGDSFYIRALYDRLADVEQELS 1613
N EE + +L G V + Q + + + + + GDSFYIR ++ + LS
Sbjct: 477 NIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLS 536
Query: 1614 FKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDD 1673
F K ++ V DTL G GSW+A ++ +N ++++RG IP+K +Q S + ++ +
Sbjct: 537 FNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKT--- 593
Query: 1674 NSATKTLSAAARRSF--FRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRV 1731
+ R F FR KR+ K +DL A P AY+RV
Sbjct: 594 -------AGGDRADFWRFRGLRSSKRNLRKSREDLSAQPV--QTKFP--------AYERV 636
Query: 1732 QKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDY 1791
+ LRPV I GP+ DV +E L E P + E A
Sbjct: 637 VLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTD-------------- 682
Query: 1792 KRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQ 1851
+R SG + + +IK+I ++++H LLD+ P+A++RL++ YPIV+F++ S + +K
Sbjct: 683 QRSSG---IIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTM 739
Query: 1852 RDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQIL-AMVNQEQNK 1910
R + +++ +++ +E + KL + FT I +++ L + Q+QN+
Sbjct: 740 RMRLC---PESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQ 796
Query: 1911 VLWI 1914
++W+
Sbjct: 797 LVWV 800
Score = 50.4 bits (119), Expect = 2e-05
Identities = 60/218 (27%), Positives = 93/218 (42%), Gaps = 19/218 (8%)
Query: 1227 HQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKAERIKIP---STP--- 1280
H GR R+ S + R+ +S S + + S ERI P STP
Sbjct: 299 HSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKH 358
Query: 1281 ---RYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGE 1337
P++V E +V +E TP P + Q P V P S E
Sbjct: 359 ADDHTPKTV---EEVTVERNEKQTP-SLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHE 414
Query: 1338 RRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEF 1397
RP + + VK +KG + +G+ + G GI+V+ V S A + GLE GDQ+L
Sbjct: 415 DGILRPSM---KLVKFRKG-DSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRV 470
Query: 1398 NGINLRSATEQQARLIIGQ--QCDTITILAQYNPHVHQ 1433
N ++ + ++A L + + + +TILAQ V++
Sbjct: 471 NNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYR 508
Score = 39.3 bits (90), Expect = 0.037
Identities = 32/122 (26%), Positives = 55/122 (45%), Gaps = 9/122 (7%)
Query: 603 SSHDSAIDTDSME----WETEVVEFERETEDIDLKALGFDMAEGVNEPCFP-GDCGIFVT 657
S+ +A + +ME WE V R G ++ G + P F G+ I ++
Sbjct: 2 SARAAAAKSTAMEETAIWEQHTVTLHRAPGF----GFGIAISGGRDNPHFQSGETSIVIS 57
Query: 658 KVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVV 717
V KG A+G+L+ ND + +N V + N + A++ L + +RR+K + V
Sbjct: 58 DVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVS 117
Query: 718 TP 719
P
Sbjct: 118 RP 119
Score = 34.7 bits (78), Expect = 0.92
Identities = 17/35 (48%), Positives = 23/35 (65%), Gaps = 1/35 (2%)
Query: 737 GVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDN 771
G++ A VL SPAAKEG L GD+I+ +N + N
Sbjct: 444 GIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTN 477
Score = 34.3 bits (77), Expect = 1.2
Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 4/52 (7%)
Query: 722 INLSGQKDSGI--SLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDN 771
I +SG +D+ S E + + VL G PA EG L DR+ +NG+++DN
Sbjct: 36 IAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDN 85
Score = 33.1 bits (74), Expect = 2.7
Identities = 33/123 (26%), Positives = 64/123 (52%), Gaps = 22/123 (17%)
Query: 599 LMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTK 658
++ +S+H+ I SM+ +V+F R+ + + L+ G + D GIFV
Sbjct: 407 VLPNSTHEDGILRPSMK----LVKF-RKGDSVGLRLAGGN------------DVGIFVAG 449
Query: 659 VDKGS-IADGRLRVNDWLLRINDVDLINKDKKQAIKALLN---GEGAINMVVRRRKSLGG 714
V + S A L D +LR+N+VD N +++A+ LL+ GE + ++ +++K +
Sbjct: 450 VLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGE-EVTILAQKKKDVYR 508
Query: 715 KVV 717
++V
Sbjct: 509 RIV 511
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 149 bits (375), Expect = 3e-35
Identities = 161/628 (25%), Positives = 279/628 (44%), Gaps = 112/628 (17%)
Query: 1354 QKGSEPLGISIVSGEKGGIYVSKVT-VGSIAHQAGLEYGDQLLEFNGINLRSATEQQARL 1412
++ SE G+ + S I++ +T G A GL+ GD +L+ NG++ ++ + R
Sbjct: 219 RRDSEEFGVKLGSQ----IFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRR 274
Query: 1413 IIGQQCDTITILA-----QYNPHVHQLSSHSRSS-------------------------- 1441
+I + +++L Q+ ++ S S SS
Sbjct: 275 LIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASEL 334
Query: 1442 -----SHLDPAGTHS--TLQGSGTTTP-EHP-----SVIDP--LMEQDEGPSTPPAKQSS 1486
SH+ P H+ + + S T +P E P S +D + E DE S P ++SS
Sbjct: 335 SQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELP-RESS 393
Query: 1487 SRIAGDANKKTLEPR--------VVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGP 1538
I + +++E R V F+K + G+ L GGN G+FV+ V+ SPA G
Sbjct: 394 YDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSI--GLRLAGGNDVGIFVSGVQAGSPADG- 450
Query: 1539 DGLVPGDLILEYGSLDVRNKTVEEV--YVEMLKPRDGVRLKVQYRPEEFTK-AKGLPGDS 1595
G+ GD IL+ + +N T EE ++ L P + + L Q + + F K + GDS
Sbjct: 451 QGIQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGDS 510
Query: 1596 FYIRALYDRLADVEQELSFKKDDILYVDDTLPQGTF------GSWMAWQLDENAQKIQRG 1649
FYIR ++ L F + D+ +V DTL G G W+A ++ + ++ +RG
Sbjct: 511 FYIRTHFELEPSPPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERG 570
Query: 1650 QIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKH---KRSGSKDGKDL 1706
IP++ +Q S + V ++ + AR F+R + K++ + +DL
Sbjct: 571 IIPNQSRAEQLASLEAAQRAVGVGPGSSA--GSNARAEFWRLRGLRRGAKKTTQRSREDL 628
Query: 1707 LALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCR 1766
AL P Y+RV + + RPV+ILGP+ D+ + L E P +F
Sbjct: 629 SALTR--QGRYP--------PYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQF-- 676
Query: 1767 CPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIE 1826
E+ + R + + +++ I EK++H LLD+ P AIE
Sbjct: 677 ---EIAET----------------VSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIE 717
Query: 1827 RLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTG 1886
RL+++ YPIV+F +S +K R + ++R ++ + AQKL + S FT
Sbjct: 718 RLNYVQYYPIVVFFIPESRPALKALRQWL---APASRRSTRRLYAQAQKLRKHSSHLFTA 774
Query: 1887 VIQ-GGALSSICTQILAMVNQEQNKVLW 1913
I G + ++ A++ ++Q + +W
Sbjct: 775 TIPLNGTSDTWYQELKAIIREQQTRPIW 802
Score = 52.0 bits (123), Expect = 6e-06
Identities = 40/143 (27%), Positives = 69/143 (48%), Gaps = 17/143 (11%)
Query: 1276 IPSTPRYPRSVVGSERGSVSHSECSTPPQSPL-----NIDTLSSCSQSQTSASTLPRIA- 1329
IP PR+ + S S+ +P +SP ++D+ + S+ S LPR +
Sbjct: 342 IPPPPRHAQR-------SPEASQTDSPVESPRLRRESSVDS-RTISEPDEQRSELPRESS 393
Query: 1330 --VNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAG 1387
+ + +DR Y + R V+ KG +G+ + G GI+VS V GS A G
Sbjct: 394 YDIYRVPSSQSMEDRGYSPDTRVVRFLKGKS-IGLRLAGGNDVGIFVSGVQAGSPADGQG 452
Query: 1388 LEYGDQLLEFNGINLRSATEQQA 1410
++ GDQ+L+ N + ++ T ++A
Sbjct: 453 IQEGDQILQVNDVPFQNLTREEA 475
Score = 49.3 bits (116), Expect = 4e-05
Identities = 50/182 (27%), Positives = 86/182 (47%), Gaps = 30/182 (16%)
Query: 569 RKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETE 628
R++ + SR + E EQ S+L +E+ + SS +++ +T VV F +
Sbjct: 368 RRESSVDSRTISEPDEQ-RSELPRESSYDIYRVPSSQ--SMEDRGYSPDTRVVRFLKG-- 422
Query: 629 DIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGR-LRVNDWLLRINDVDLINKD 687
K++G +A G D GIFV+ V GS ADG+ ++ D +L++NDV N
Sbjct: 423 ----KSIGLRLAGG-------NDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLT 471
Query: 688 KKQAIKALLN---GEGAINMVVRRRKSLGGKVVTP---------LHINLSGQKDSGISLE 735
+++A++ LL GE + +V +R++ + K+V H L SG+
Sbjct: 472 REEAVQFLLGLPPGE-EMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFT 530
Query: 736 NG 737
G
Sbjct: 531 RG 532
Score = 41.2 bits (95), Expect = 0.010
Identities = 28/119 (23%), Positives = 54/119 (45%), Gaps = 8/119 (6%)
Query: 709 RKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIA 768
R+ + K V + + ++ G+ L + ++ + AA+ L GD I+ ING++
Sbjct: 204 RQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVS 263
Query: 769 LDNKSLNECESLLRSCQDSLTLSLLK--------VFPQSSSWSGQNIFENIKDSDKMLS 819
N SLN+ L+ + L+L +L+ + P S + E + +D+M S
Sbjct: 264 SQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMSS 322
Score = 37.4 bits (85), Expect = 0.14
Identities = 17/42 (40%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Query: 743 VLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSC 784
V+PG PA EG L GD IV +NG++++N + +L++C
Sbjct: 61 VVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFAIQILKTC 100
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 140 bits (354), Expect = 9e-33
Identities = 122/477 (25%), Positives = 221/477 (46%), Gaps = 55/477 (11%)
Query: 1446 PAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFI 1505
P ST +GT PE +P ++D P A + ++ P +
Sbjct: 456 PTPFKSTGDIAGTVVPETNK--EPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMV 513
Query: 1506 K-KSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVY 1564
+ K +G+ L GGN G+FVA +++ + A+ +GL GD IL+ + D R E+
Sbjct: 514 RFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAE-QEGLQEGDQILKVNTQDFRGLVREDAV 572
Query: 1565 VEMLKPRDG--VRLKVQYRPEEFTKAKGLP-GDSFYIRALYDRLADVEQELSFKKDDILY 1621
+ +L+ G V + Q R + + GDSF+IR+ ++ + Q L+F + ++
Sbjct: 573 LYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFR 632
Query: 1622 VDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLS 1681
V DTL G G+W+A ++ ++++G IP+K +Q S+ + DN
Sbjct: 633 VVDTLYDGKLGNWLAVRI---GNELEKGLIPNKSRAEQ----MASVQNAQRDN------- 678
Query: 1682 AAARRSFFRRKHKH---KRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTA 1738
A R F+R + + K++ K +DL A+ + S+ P AY+RV +
Sbjct: 679 AGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVST-KFP--------AYERVLLREAGF 729
Query: 1739 LRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHF 1798
RPV++ GP+ D+ E L NE P F E A + + +G
Sbjct: 730 KRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSE---------------KSTG-- 772
Query: 1799 DVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLR 1858
V + ++++I E+++H LLD+ P A++ L++ +PIVIF + S + +K R +
Sbjct: 773 -VVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRL--- 828
Query: 1859 DKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQ-GGALSSICTQILAMVNQEQNKVLWI 1914
+ + + S++ F+ A KL++ + FT I A S + + +Q + +W+
Sbjct: 829 NPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWV 885
Score = 46.2 bits (108), Expect = 3e-04
Identities = 28/92 (30%), Positives = 51/92 (55%), Gaps = 3/92 (3%)
Query: 1344 YVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEFNGINLR 1403
Y + V+ +KG + +G+ + G GI+V+ + G+ A Q GL+ GDQ+L+ N + R
Sbjct: 506 YGPNTKMVRFKKG-DSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFR 564
Query: 1404 SATEQQARLIIGQ--QCDTITILAQYNPHVHQ 1433
+ A L + + + + +TILAQ V++
Sbjct: 565 GLVREDAVLYLLEIPKGEMVTILAQSRADVYR 596
Score = 43.9 bits (102), Expect = 0.002
Identities = 30/116 (25%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Query: 728 KDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDS 787
++ G+ L + ++ + A K+G+L GD I+ ING +N SL + L+ +
Sbjct: 317 EEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGK 376
Query: 788 LTLSLLKVFPQS--SSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNS 841
L L +L+ Q+ + S + I+D ++ S R+ PE + H + H++S
Sbjct: 377 LQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSS 432
>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
[Homo sapiens]
Length = 1190
Score = 140 bits (354), Expect = 9e-33
Identities = 122/477 (25%), Positives = 221/477 (46%), Gaps = 55/477 (11%)
Query: 1446 PAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFI 1505
P ST +GT PE +P ++D P A + ++ P +
Sbjct: 456 PTPFKSTGDIAGTVVPETNK--EPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMV 513
Query: 1506 K-KSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVY 1564
+ K +G+ L GGN G+FVA +++ + A+ +GL GD IL+ + D R E+
Sbjct: 514 RFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAE-QEGLQEGDQILKVNTQDFRGLVREDAV 572
Query: 1565 VEMLKPRDG--VRLKVQYRPEEFTKAKGLP-GDSFYIRALYDRLADVEQELSFKKDDILY 1621
+ +L+ G V + Q R + + GDSF+IR+ ++ + Q L+F + ++
Sbjct: 573 LYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFR 632
Query: 1622 VDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLS 1681
V DTL G G+W+A ++ ++++G IP+K +Q S+ + DN
Sbjct: 633 VVDTLYDGKLGNWLAVRI---GNELEKGLIPNKSRAEQ----MASVQNAQRDN------- 678
Query: 1682 AAARRSFFRRKHKH---KRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTA 1738
A R F+R + + K++ K +DL A+ + S+ P AY+RV +
Sbjct: 679 AGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVST-KFP--------AYERVLLREAGF 729
Query: 1739 LRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHF 1798
RPV++ GP+ D+ E L NE P F E A + + +G
Sbjct: 730 KRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSE---------------KSTG-- 772
Query: 1799 DVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLR 1858
V + ++++I E+++H LLD+ P A++ L++ +PIVIF + S + +K R +
Sbjct: 773 -VVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRL--- 828
Query: 1859 DKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQ-GGALSSICTQILAMVNQEQNKVLWI 1914
+ + + S++ F+ A KL++ + FT I A S + + +Q + +W+
Sbjct: 829 NPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWV 885
Score = 46.2 bits (108), Expect = 3e-04
Identities = 28/92 (30%), Positives = 51/92 (55%), Gaps = 3/92 (3%)
Query: 1344 YVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEFNGINLR 1403
Y + V+ +KG + +G+ + G GI+V+ + G+ A Q GL+ GDQ+L+ N + R
Sbjct: 506 YGPNTKMVRFKKG-DSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFR 564
Query: 1404 SATEQQARLIIGQ--QCDTITILAQYNPHVHQ 1433
+ A L + + + + +TILAQ V++
Sbjct: 565 GLVREDAVLYLLEIPKGEMVTILAQSRADVYR 596
Score = 43.9 bits (102), Expect = 0.002
Identities = 30/116 (25%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Query: 728 KDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDS 787
++ G+ L + ++ + A K+G+L GD I+ ING +N SL + L+ +
Sbjct: 317 EEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGK 376
Query: 788 LTLSLLKVFPQS--SSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNS 841
L L +L+ Q+ + S + I+D ++ S R+ PE + H + H++S
Sbjct: 377 LQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSS 432
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 129 bits (324), Expect = 3e-29
Identities = 94/342 (27%), Positives = 168/342 (49%), Gaps = 51/342 (14%)
Query: 1595 SFYIRAL--YDRLADV---EQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRG 1649
S Y+RA+ YD+ D Q LSFK DIL+V + W A ++ + G
Sbjct: 20 SLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGDSEEMG 76
Query: 1650 QIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLAL 1709
IPSK ++++ RL KT+ A+ K G G L
Sbjct: 77 VIPSKRRVERKERARL------------KTVKFNAKPGVIDSK------GDIPG---LGD 115
Query: 1710 DAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPL 1769
D + + ++ ED + L+Y+ V + + RPV+ILGP+ D + + L++E P KF C
Sbjct: 116 DGYGTKTLRGQEDLI-LSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVP 174
Query: 1770 EVMKA---------------SQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNR 1814
+ S++ +E+ +++ F++ + + + T+V S++ + E+ +
Sbjct: 175 HTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGK 234
Query: 1815 HCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQ 1874
HC+LD++ +AI+RL +YPI IFI +S + + E + ++T+ +K+ ++ A
Sbjct: 235 HCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME------MNKRLTEEQAKKTYDRAI 288
Query: 1875 KLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
KLEQE+ YFT ++QG L I Q ++ ++ +WIP+
Sbjct: 289 KLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 330
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 103 bits (258), Expect = 1e-21
Identities = 107/489 (21%), Positives = 205/489 (41%), Gaps = 65/489 (13%)
Query: 1465 SVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGNLHGV 1524
SV D + +++ P PP + D + + +++ + K++ LG + G
Sbjct: 109 SVHDTVAQKNYDPVLPPMPE-------DIDDEEDSVKIIRLVKNREPLGATIKKDEQTGA 161
Query: 1525 FVAEVEDDSPAKGPDGLVP-GDLILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQYRPE 1583
+ A GL+ GD + E + V +K EE+ + + + + K+ +
Sbjct: 162 IIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSK 221
Query: 1584 EFTKAKGLPGDSFYIRALYD-------RLADVEQELSFKKDDILYV---DDTLPQGTFGS 1633
E T +K +I+AL+D + E LSFKK DIL + DD +
Sbjct: 222 EETPSKE---GKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDA-------T 271
Query: 1634 WMAWQLDENAQKIQR-GQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRK 1692
W WQ A R G IPSK+ ++ + R E+ ++ R FR
Sbjct: 272 W--WQAKHEADANPRAGLIPSKHFQERRLALR--RPEILVQPLKVSNRKSSGFRKSFRLS 327
Query: 1693 HKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGP----L 1748
K K++ +K + D + + +P +E+ Q +K R V+++GP L
Sbjct: 328 RKDKKT-NKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKY-----RLVVLVGPVGVGL 381
Query: 1749 LDVVKEMLVNEAPGKFCRCP-------------LEVMKASQQAIERGVKDCLFVDYKRRS 1795
++ +++L+++ P +E + S+ E V++ F++Y
Sbjct: 382 NELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYK 441
Query: 1796 GHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKE----- 1850
++ T++ S++ + KN+ CLLD+ PH ++ L + P VIFI S + ++E
Sbjct: 442 NNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNA 501
Query: 1851 ----QRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQ 1906
RD T+ +E ++AQ +E +Y F +I L+ ++ ++
Sbjct: 502 KIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDK 561
Query: 1907 EQNKVLWIP 1915
+ + W+P
Sbjct: 562 LETETHWVP 570
Score = 40.4 bits (93), Expect = 0.017
Identities = 25/74 (33%), Positives = 41/74 (55%), Gaps = 2/74 (2%)
Query: 1351 VKVQKGSEPLGISIVSGEK-GGIYVSKVTVGSIAHQAGLEY-GDQLLEFNGINLRSATEQ 1408
+++ K EPLG +I E+ G I V+++ G A ++GL + GD+L E NGI + +
Sbjct: 140 IRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPE 199
Query: 1409 QARLIIGQQCDTIT 1422
+ I+ Q IT
Sbjct: 200 EIIQILAQSQGAIT 213
Score = 35.0 bits (79), Expect = 0.71
Identities = 15/56 (26%), Positives = 30/56 (53%)
Query: 738 VYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLL 793
+ A ++ G A + G + VGD + +NGI +++K E +L Q ++T ++
Sbjct: 162 IIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKII 217
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 93.6 bits (231), Expect = 2e-18
Identities = 118/511 (23%), Positives = 221/511 (43%), Gaps = 65/511 (12%)
Query: 145 KVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQC---VRAMSD 201
+V++L Q +T E EL+++L K R+ + E L+ Q V S
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
Query: 202 LQS-LQNQHTNALKRCEEV--AKETDFYHTLHSRLLSDQ-TRLKDDVDMLRR----ENGQ 253
LQ L+ K EE+ K H R L DQ + + D++D +R E G
Sbjct: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGA 727
Query: 254 LLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVV 313
L+ E +Q +D+ + +E+Q+++ LR +++++ G+ + +D MDKL
Sbjct: 728 LIEELLQAKQDLQDLL-IAKEEQEDL--LRKRERELTALKGALKEEVSSHDQEMDKL--- 781
Query: 314 KKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSL 373
K+ YDA L+ L E + K E+L + +T+ Q Q A +
Sbjct: 782 KEQYDA-----------------ELQALRESVEEATKNVEVLASRSNTSEQDQ---AGTE 821
Query: 374 RRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYK 433
R + + E K ++++L+ + LQ ++ +L+ + K + +KY E +
Sbjct: 822 MRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALV 881
Query: 434 LIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEM-------EALRQIKDTVTM 486
E + +S L+ E+E A+ L +T E+K +E++ E LR++K+ +
Sbjct: 882 HARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMEN 941
Query: 487 DAGRANKEVEILRKQCKALCQ-------ELKEALQEADVAKCRRDWAFQERD--KIVAER 537
+ K +E L+K+ + + EL+ L E K RR+ A +R + E
Sbjct: 942 ERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYK-EKNRRELAEMQRQLKEKTLEA 1000
Query: 538 DSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFR 597
+ R ++ E EL + R+ D+ ++ + + LK+L+ ++E++
Sbjct: 1001 EKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAK-------- 1052
Query: 598 QLMAHSSHDSAIDTDSMEWETEVVEFERETE 628
+H D + ME + +E E E E
Sbjct: 1053 ---SHLKDDRSRLVKQMEDKVSQLEMELEEE 1080
Score = 57.0 bits (136), Expect = 2e-07
Identities = 52/252 (20%), Positives = 117/252 (46%), Gaps = 35/252 (13%)
Query: 386 ATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISE 445
+T++ KDL + L E+ EL+ K + +EER+ + + + + S+ ++ + E
Sbjct: 605 STSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEE 664
Query: 446 LDKLQTEVELAESKLKSSTSE----KKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQ 501
LQ +E +E +L+ + E K + +R ++D ++ + ++
Sbjct: 665 NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDRE 724
Query: 502 CKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEA 561
AL +EL +A Q+ +D ++A+ + ++L R+R+R ++ L A
Sbjct: 725 KGALIEELLQAKQDL-------------QDLLIAKEEQ-----EDLLRKRERELTALKGA 766
Query: 562 LRSLDDTRKQKNDVSRELKELKEQMESQL-------EKEARFRQLMAHSSHDSAIDTDSM 614
L +++ + +E+ +LKEQ +++L E+ + +++A S+ S D
Sbjct: 767 L------KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGT 820
Query: 615 EWETEVVEFERE 626
E ++++ E E
Sbjct: 821 EMRVKLLQEENE 832
Score = 55.1 bits (131), Expect = 7e-07
Identities = 87/422 (20%), Positives = 182/422 (43%), Gaps = 56/422 (13%)
Query: 187 DYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDM 246
+ ER Q R + DL+ + + LK+ E ++ L L+ + K+ V
Sbjct: 840 ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQ------LEEALVHARKEEKEAVSA 893
Query: 247 LRRENGQLLRERNLLQQSWEDMKRLHE------EDQKEIGDLRAQQQQVLKHNGSSEILN 300
R +L + L Q+ ++ K+L E E ++++ L+ + + H G + +
Sbjct: 894 RRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKT--IE 951
Query: 301 KLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRD 360
KL D +E + L+ + E + +L+ +++ +L ++T + R
Sbjct: 952 KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR------QLKEKTLEAEKSRL 1005
Query: 361 TAIQLQHQCALSLRRFEAIHHELNKATAQN-------KDLQWEMELLQSELTELRTTQVK 413
TA+++Q + L ++A + KDL++E+E +S L + R+ VK
Sbjct: 1006 TAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA-KSHLKDDRSRLVK 1064
Query: 414 TAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEE 473
++ E ++SER + + + ++E +L++ +++AA ++
Sbjct: 1065 QMEDKVSQLEMELEEERNNSDLLSER------ISRSREQME----QLRNELLQERAARQD 1114
Query: 474 MEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEAL---QEADVAKCRRDWAFQER 530
+E D ++++ R NK+++ + + KE L EA +A+ +ER
Sbjct: 1115 LEC-----DKISLE--RQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEER 1167
Query: 531 DKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQL 590
D+ + + R L R+ V ++ + SL D QK+ +S LK +K Q+E
Sbjct: 1168 DRANLQLSNRR-----LERKVKELVMQVDDEHLSLTD---QKDQLSLRLKAMKRQVEEAE 1219
Query: 591 EK 592
E+
Sbjct: 1220 EE 1221
Score = 52.8 bits (125), Expect = 3e-06
Identities = 79/383 (20%), Positives = 151/383 (39%), Gaps = 52/383 (13%)
Query: 161 NELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVA 220
NEL + T K+ +L + E+ K Q R ++++ N+ + K E++
Sbjct: 899 NELEAAQGNLSQTTQEQKQLSEKLKEESEQ-KEQLRRLKNEME---NERWHLGKTIEKLQ 954
Query: 221 KE-TDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRE----------RNLLQQSWEDMK 269
KE D + L Q +L + + RRE ++ R+ L +D
Sbjct: 955 KEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEM 1014
Query: 270 RLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVA 329
RL EE+ ++ RAQ + + K + L L + ++ +K D L K+ +KV
Sbjct: 1015 RLMEEELRDYQ--RAQDEALTKRQLLEQTLKDL-EYELEAKSHLKDDRSRLVKQMEDKV- 1070
Query: 330 IHNADLSRLE-QLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATA 388
S+LE +L EE +E +++ R+ QL+++ + + +
Sbjct: 1071 ------SQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLER 1124
Query: 389 QNKDLQWEM--------------------------ELLQSELTELRTTQVKTAKESEKYR 422
QNKDL+ + + L+SE + Q+ + K +
Sbjct: 1125 QNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVK 1184
Query: 423 EERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKD 482
E V E+ + ++DQ+ L ++ +VE AE ++ S KK E+E + +
Sbjct: 1185 ELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNE 1244
Query: 483 TVTMDAGRANKEVEILRKQCKAL 505
+ K++ + + K L
Sbjct: 1245 HLQGQLNSMKKDLRLKKLPSKVL 1267
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 87.8 bits (216), Expect = 9e-17
Identities = 106/496 (21%), Positives = 209/496 (42%), Gaps = 52/496 (10%)
Query: 140 QQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRAM 199
+Q NL + + ER EL + G + ++ + L+++
Sbjct: 1206 EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGE 1265
Query: 200 SDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSD----QTRLKDDVDMLRRENGQLL 255
L ++ T + V + S+L D +++L+D ++L+ EN Q L
Sbjct: 1266 RVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKL 1325
Query: 256 R----------ERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDT 305
E+N ++ E+ + +K+I L AQ + K S +T
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSV---GCLET 1382
Query: 306 AMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQL 365
A + ++KD + L +R+ EKVA ++ +L +E LL L QR +A L
Sbjct: 1383 AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVD---LDHQRQSACNL 1439
Query: 366 QHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREER 425
+ + ++F+ + E +A+ + E + ++E E T + A+ E+ E++
Sbjct: 1440 EKK----QKKFDQLLAEEKTISAKYAE---ERDRAEAEAREKETKALSLARALEEAMEQK 1492
Query: 426 DAVYSEYKLIMSERDQVISELD---KLQTEVELAESKLKSSTSEKKAANEEME-ALRQIK 481
+ K +E + ++S D K E+E ++ L+ E K EE+E L+ +
Sbjct: 1493 AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE 1552
Query: 482 DT-----VTMDAGRANKEVEI------LRKQCKALCQELKEALQEADVAKCRRDWAFQER 530
D V + A +A E ++ ++ K L ++++E E + + +R A R
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAAR 1612
Query: 531 DKIVAERDSIRTLCDNLRRERDRAVSEL-------AEALRSLDDTRKQKNDVSRELKELK 583
K+ + + D+ + RD A+ +L + +R LDDTR + ++ + KE +
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENE 1672
Query: 584 EQMESQLEKEARFRQL 599
++++S EA QL
Sbjct: 1673 KKLKSM---EAEMIQL 1685
Score = 75.1 bits (183), Expect = 6e-13
Identities = 79/391 (20%), Positives = 186/391 (47%), Gaps = 40/391 (10%)
Query: 228 TLHSRLLSDQTRLKDDVDM-------LRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIG 280
TL S+L++++ +L++ + +L ++ L++ D++ EE+++
Sbjct: 873 TLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQ 932
Query: 281 DLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAI---HNADLSR 337
L+A+++++ ++ E + ++A KL++ K +A K+ E+ I N L++
Sbjct: 933 HLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAK 992
Query: 338 LEQLGEENQRLLKQTEMLTQQRDTAIQL-----QHQCALS-----LRRFEAIHHELNKAT 387
++L E+ R+ + T LT++ + + L +H+ ++ LRR E EL K
Sbjct: 993 EKKLLED--RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTR 1050
Query: 388 AQ----NKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVI 443
+ + DL ++ LQ+++ EL+ K +E + + ++ + + + ++
Sbjct: 1051 RKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELE 1110
Query: 444 SELDKLQTEVELAESKLKSSTSEKKAANEEMEALR-QIKDTVTMDA------GRANKEVE 496
S++ +LQ ++E + + +K+ EE+EAL+ +++DT+ A + +EV
Sbjct: 1111 SQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVN 1170
Query: 497 ILRK----QCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERD 552
IL+K + K +++E Q+ A ++ ++ A + + +N ER
Sbjct: 1171 ILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN---ERG 1227
Query: 553 RAVSELAEALRSLDDTRKQKNDVSRELKELK 583
+E+ L+ D+ ++ V +L+EL+
Sbjct: 1228 ELANEVKVLLQGKGDSEHKRKKVEAQLQELQ 1258
Score = 68.2 bits (165), Expect = 8e-11
Identities = 93/469 (19%), Positives = 199/469 (42%), Gaps = 43/469 (9%)
Query: 197 RAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLR 256
RA ++ + + + + + EE ++ L+ + ++ L D + + +L +
Sbjct: 1466 RAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEK 1525
Query: 257 ERNLLQQSWEDMKRLHEEDQKEI-----GDLRAQQQ-QVLKHNGSSEILNKLYDTAMDKL 310
+ L+Q E+MK EE + E+ LR + Q +K ++ + + K
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKK 1585
Query: 311 EVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQ----LQ 366
++V++ + + E+ A +R ++L + + L + + RD AI+ LQ
Sbjct: 1586 QLVRQVREMEAELEDERKQRSMAVAAR-KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ 1644
Query: 367 HQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERD 426
Q +R + + AQ K+ + +++ +++E+ +L+ + + ++ERD
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERD 1704
Query: 427 AVYSEYK-------LIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQ 479
+ E L + E+ ++ + + +L+ E+E + + K AN +++ Q
Sbjct: 1705 ELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQID---Q 1761
Query: 480 IKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEAD-VAKCRRDWAFQERDKIVAERD 538
I + ++ A K E R+Q + +ELK LQE + K + + + +A+
Sbjct: 1762 INTDLNLERSHAQKN-ENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQ-- 1818
Query: 539 SIRTLCDNLRRERD-------RAVSELAEALRSLDDTRK-------QKNDVSRELKELKE 584
+ DN +ER R +L + L +DD R+ Q + S LK+LK
Sbjct: 1819 -LEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKR 1877
Query: 585 QMESQLEKEAR---FRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDI 630
Q+E E+ R R+ + D+ D+M E ++ + D+
Sbjct: 1878 QLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDL 1926
Score = 67.8 bits (164), Expect = 1e-10
Identities = 80/350 (22%), Positives = 160/350 (45%), Gaps = 31/350 (8%)
Query: 302 LYDTAMDKLEVVKKDYDALRKRYSEKVAIHN-ADLSRLE-QLGEENQRLLKQTEMLTQQR 359
L + + E++ K+ + ++ R + A + ++ L+ QL E +L +Q + T+
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 360 DTAIQLQHQCALSLRRFEAIHHELNKATAQNKD----LQWEMELLQSELTELRTTQVKTA 415
A +L+ + + E I H+L + ++ LQ E + +Q + EL +
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELE--EQLEE 954
Query: 416 KESEKYREERDAVYSEYKLIMSERDQVISELD--KLQTEVELAESKLKSSTSEKKAANEE 473
+ES + + + + V +E KL E +Q+I E KL E +L E ++ T+ E+
Sbjct: 955 EESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014
Query: 474 MEALRQIK---DTVTMDAG-------RANKEVEILRKQCKALCQELKEALQE--ADVAKC 521
++L ++K + + D + +E+E R++ + +L + + E A +A+
Sbjct: 1015 SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL 1074
Query: 522 RRDWAFQERDKIVA-----ERDSIRTLCDNLRRERDRAVSELAEALRSLDDTR----KQK 572
+ A +E + A E + + + RE + +SEL E L S +R KQK
Sbjct: 1075 KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQK 1134
Query: 573 NDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVE 622
D+ EL+ LK ++E L+ A ++L + + I ++E E + E
Sbjct: 1135 RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184
Score = 54.7 bits (130), Expect = 9e-07
Identities = 83/434 (19%), Positives = 169/434 (38%), Gaps = 40/434 (9%)
Query: 187 DYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDM 246
+ ERL Q M DL S ++ ++ E+ + L ++ +T+L++ D
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKR------ALEQQVEEMKTQLEELEDE 1547
Query: 247 LRR-ENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDT 305
L+ E+ +L E NL + + L D++ + +QV + E K
Sbjct: 1548 LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSM 1607
Query: 306 AMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQL 365
A+ + ++ D L + + +L +L + + +++ + R+ +
Sbjct: 1608 AVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ 1667
Query: 366 QHQCALSLRRFEA----IHHELNKATAQNKDLQWEMELLQSE-----------LTELRTT 410
+ L+ EA + EL A + Q E + L E L E R
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727
Query: 411 QVKTAKESEKYREER---DAVYSEYKLIMSERDQVISELDKLQTEV---ELAESKLKSST 464
+ + A+ E+ EE+ + + K + DQ+ ++L+ ++ E A +L+
Sbjct: 1728 EARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQN 1787
Query: 465 SEKKAANEEMEALRQIKDTVTMDAGRAN------------KEVEILRKQCKALCQELKEA 512
E K +EME + K ++ A A KE + KQ + ++LK+
Sbjct: 1788 KELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDV 1847
Query: 513 LQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQK 572
L + D + + + DK ++ + E RA + + R L+D +
Sbjct: 1848 LLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETA 1907
Query: 573 NDVSRELKELKEQM 586
+ ++RE+ LK ++
Sbjct: 1908 DAMNREVSSLKNKL 1921
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 85.1 bits (209), Expect = 6e-16
Identities = 92/446 (20%), Positives = 191/446 (42%), Gaps = 59/446 (13%)
Query: 1501 RVVFIKKSQ-LELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKT 1559
++V I+K++ + LG + + V ++ + A+ L GD +LE +++R K
Sbjct: 255 KIVRIEKARDIPLGATV-RNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKD 313
Query: 1560 VEEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDR-------LADVEQEL 1612
V EV+ ++L G L P + K +++A +D + E L
Sbjct: 314 VNEVF-DLLSDMHGT-LTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGL 371
Query: 1613 SFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKD 1672
SF+K DIL+V + Q W A++ + + G +P K Q + + ++ E K+
Sbjct: 372 SFQKGDILHV---ISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKE 428
Query: 1673 DNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQ 1732
+ K A + K K K+ K+ D + ++ I +E+ +SL +Q
Sbjct: 429 PEKSGKLWCAK------KNKKKRKKVLYNANKN----DDYDNEEILTYEE-MSLYHQPAN 477
Query: 1733 KVDCTALRPVLILGPL---LDVVKEMLVNEAPGKFCRCPLEVMKA--------------S 1775
+ RP++++GP + +++ L+N+ +F ++ S
Sbjct: 478 RK-----RPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVS 532
Query: 1776 QQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYP 1835
+QA E + F+++ + T++ S++++ + CLL + +++ L + + P
Sbjct: 533 RQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKP 592
Query: 1836 IVIFIHYKSAKHI-----KEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQG 1890
+IFI S + + KE ++P +E E +++EQ YF I
Sbjct: 593 YIIFIAPPSQERLRALLAKEGKNP-------KPEELREIIEKTREMEQNNGHYFDTAIVN 645
Query: 1891 GALSSICTQILAMVNQEQNKVLWIPA 1916
L ++L ++N+ + W+P+
Sbjct: 646 SDLDKAYQELLRLINKLDTEPQWVPS 671
Score = 41.6 bits (96), Expect = 0.008
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 3/84 (3%)
Query: 713 GGKVVTPLHINLSGQKDSGISLEN---GVYAAAVLPGSPAAKEGSLAVGDRIVAINGIAL 769
GG+ V + I + G ++ N V + ++ G A K G L GD ++ INGI +
Sbjct: 250 GGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEI 309
Query: 770 DNKSLNECESLLRSCQDSLTLSLL 793
K +NE LL +LT L+
Sbjct: 310 RGKDVNEVFDLLSDMHGTLTFVLI 333
Score = 38.5 bits (88), Expect = 0.064
Identities = 23/81 (28%), Positives = 44/81 (54%), Gaps = 3/81 (3%)
Query: 1346 EEPRHVKVQKGSE-PLGISIVSGEKGGIYVSKVTVGSIAHQAGLEY-GDQLLEFNGINLR 1403
E + V+++K + PLG + V E + +S++ G A ++GL + GD++LE NGI +R
Sbjct: 252 ETVKIVRIEKARDIPLGAT-VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIR 310
Query: 1404 SATEQQARLIIGQQCDTITIL 1424
+ ++ T+T +
Sbjct: 311 GKDVNEVFDLLSDMHGTLTFV 331
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 84.3 bits (207), Expect = 1e-15
Identities = 120/578 (20%), Positives = 231/578 (39%), Gaps = 108/578 (18%)
Query: 141 QVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRAMS 200
++ E+++NL + + +E++E + + L+ E +
Sbjct: 1203 ELGEQIDNLQRVKQKLEKEKSEFKLEI--------------DDLSSSMESVSKSKANLEK 1248
Query: 201 DLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNL 260
++L++Q + A + EE+ + T SRL ++ L ++ QL R +
Sbjct: 1249 ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQA 1308
Query: 261 LQQSWEDMKRLHEEDQKEIGDLR------------AQQQQVLKHNGSSEILNKL------ 302
Q E++KR EE+ K L ++Q + G +E+ L
Sbjct: 1309 FTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1368
Query: 303 -------YDT----AMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQ 351
Y+T ++LE KK + E+V NA + LE + QRL +
Sbjct: 1369 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLE---KTKQRLQGE 1425
Query: 352 TEMLTQQRDTAIQLQHQCALSLRRFEAI-----------HHELNKATAQNKDLQWEMELL 400
E L + A L R F+ + EL + +++ L E+ L
Sbjct: 1426 VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKL 1485
Query: 401 QSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKL 460
++ E Q++T K K E+ A +E ++E + I EL+K + ++EL ++ +
Sbjct: 1486 KNAYEE-ALDQLETVKRENKNLEQEIADLTEQ---IAENGKTIHELEKSRKQIELEKADI 1541
Query: 461 KSSTSEKKAANEEMEA--------LRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEA 512
+ + E +AA E EA L Q+K + ++E+E L++ + + ++ A
Sbjct: 1542 QLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSA 1601
Query: 513 LQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQK 572
L +A+V R+ A + + K+ + + I + R+ + L L DT+
Sbjct: 1602 L-DAEVRS--RNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHL 1658
Query: 573 NDVSRELKELKEQ-----------------MESQLEKEARFRQL-------------MAH 602
+D R ++LKEQ + + LE+ R R+L + H
Sbjct: 1659 DDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLH 1718
Query: 603 SSHDSAI------DTDSMEWETEVVEFERETEDIDLKA 634
+ + S I +TD M+ ++EV + R+ + + KA
Sbjct: 1719 TQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKA 1756
Score = 65.5 bits (158), Expect = 5e-10
Identities = 93/526 (17%), Positives = 218/526 (41%), Gaps = 52/526 (9%)
Query: 144 EKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRAMSDLQ 203
++ E L + + + + +++ A ++ RL + E L + RA S
Sbjct: 1382 QRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAA 1441
Query: 204 SLQNQHTNALK-------RCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLR 256
+L + N K +CEE E + L ++ +LK+ + + + R
Sbjct: 1442 ALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKR 1501
Query: 257 ERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEV---- 312
E L+Q D+ E+ K I +L ++Q+ ++ + + A++ E
Sbjct: 1502 ENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILR 1561
Query: 313 VKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEML----TQQRDTAIQLQHQ 368
++ + ++ K+A + ++ EQL QR ++ + + R+ AI+L+ +
Sbjct: 1562 IQLELTQVKSEIDRKIAEKDEEI---EQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKK 1618
Query: 369 CALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAV 428
L E +L+ A Q + + +Q +L + + + E +E+ V
Sbjct: 1619 MEGDLNEIEI---QLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIV 1675
Query: 429 YSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDA 488
L+ +E +++ + L++ + +LAE +L S + + + +L K + D
Sbjct: 1676 ERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDL 1735
Query: 489 GRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLR 548
+ EVE + + ++ K+A+ +A + +++ E+D+ L + ++
Sbjct: 1736 MQLQSEVEDASRDARNAEEKAKKAITDAAMM----------AEELKKEQDTSAHL-ERMK 1784
Query: 549 RERDRAVSELAEAL-----RSLDDTRKQKNDVSRELKELKEQMESQLEK----------- 592
+ ++ V +L L +L +KQ + ++EL+ ++E + +K
Sbjct: 1785 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKY 1844
Query: 593 EARFRQLMAHSSHD--SAIDTDSM--EWETEVVEFERETEDIDLKA 634
E R ++L S D + + + + + +V ++R+ E+ D +A
Sbjct: 1845 ERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQA 1890
Score = 61.2 bits (147), Expect = 9e-09
Identities = 104/463 (22%), Positives = 191/463 (41%), Gaps = 66/463 (14%)
Query: 217 EEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQ-QSWEDMKRLHEED 275
+E+A + + L + + K+ L + L++E+N LQ Q + + L + +
Sbjct: 848 KEMATMKEEFQKTKDELAKSEAKRKE----LEEKLVTLVQEKNDLQLQVQAESENLLDAE 903
Query: 276 Q------KEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLE----VVKKDYDALRKRYS 325
+ K L A+ ++V + E +N KLE +KKD D L +
Sbjct: 904 ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 963
Query: 326 EKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNK 385
+ +A ++++ L EE L + LT+++ A+Q HQ AL +A ++N
Sbjct: 964 KVEKEKHATENKVKNLTEELSGLDETIAKLTREK-KALQEAHQQALD--DLQAEEDKVNS 1020
Query: 386 ATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISE 445
L+ ++E L+S L + + +V + K + + +++ Q+
Sbjct: 1021 LNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDER 1080
Query: 446 LDK-------LQTEVE-------LAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRA 491
L K LQ++VE + K+K + + EE+EA R + +
Sbjct: 1081 LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATR-------AKT 1133
Query: 492 NKEVEILRKQCKALCQELKEA------------LQEADVAKCRRDW--AFQERDKIVA-- 535
K+ ++ + L + L+EA +EA+ K RRD A + + +VA
Sbjct: 1134 EKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAAL 1193
Query: 536 ---ERDSIRTL---CDNLRRERDRAVSELAEALRSLDDTRKQKNDVSR---ELKELKEQM 586
DS+ L DNL+R + + E +E +DD VS+ L+++ +
Sbjct: 1194 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTL 1253
Query: 587 ESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETED 629
E QL EAR + S S + T +TE E R+ E+
Sbjct: 1254 EDQL-SEARGKNEEIQRSL-SELTTQKSRLQTEAGELSRQLEE 1294
Score = 39.3 bits (90), Expect = 0.037
Identities = 65/352 (18%), Positives = 139/352 (39%), Gaps = 29/352 (8%)
Query: 139 DQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRA 198
D +V + E + ++ + M + NE+ +L+ A A + + + ++ A
Sbjct: 1603 DAEVRSRNEAIRLKKK-MEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDA 1661
Query: 199 MSDLQSLQNQHTNALKRCEEVAKETD-----FYHTLHSRLLSDQTRLKDD--VDMLRREN 251
+ + L+ Q +R + E + T +R L++Q L + V +L +N
Sbjct: 1662 LRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQN 1721
Query: 252 GQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLE 311
L+ + L+ D+ +L E + D R +++ K + D AM E
Sbjct: 1722 TSLIHTKKKLET---DLMQLQSEVEDASRDARNAEEKAKK---------AITDAAM-MAE 1768
Query: 312 VVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAI-QLQHQCA 370
+KK+ D K + +L E Q LK + Q+ +T I +L+ +
Sbjct: 1769 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELE 1828
Query: 371 LSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYS 430
++ L K + K+L ++ E + + L+ K + + Y+ + +
Sbjct: 1829 GEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADE 1888
Query: 431 EYKLIMSERDQVISELDKLQTEVELAES-------KLKSSTSEKKAANEEME 475
+ +++ + EL++ + ++AES K + TS + +E E
Sbjct: 1889 QANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 80.9 bits (198), Expect = 1e-14
Identities = 88/400 (22%), Positives = 171/400 (42%), Gaps = 26/400 (6%)
Query: 247 LRRENGQLLRERN--LLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYD 304
L++E QLLRE +Q WE R +E Q+E L ++++ + + +
Sbjct: 996 LQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEE 1055
Query: 305 TAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQ--LGEENQRLLKQTEMLTQQRDTA 362
++ +++ ++ + R++ E+ +L + E+ L EE ++ +Q + +
Sbjct: 1056 LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115
Query: 363 IQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYR 422
+Q + + L R + EL + + +++Q E E L E E R Q + +YR
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQ----ELERQYR 1171
Query: 423 EERDAVYSEYKLIMSERDQVISELDK-LQTEVELAESKLKSSTSEKKAANE-----EMEA 476
EE + E +L+ E+++ E ++ + E EL K K ++ ++ E E
Sbjct: 1172 EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEK 1231
Query: 477 LRQIKDTVTMDAGRANKEVEILR------KQCKALCQELKEALQEADVAKCRRDWAFQER 530
++D GR N++ L +Q + Q L QE D + RR W Q+R
Sbjct: 1232 ENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW--QQR 1289
Query: 531 DKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKE----LKEQM 586
D+ E + + + RDR E + LR + ++++ + R+ +E L+E+
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349
Query: 587 ESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERE 626
E L ++ R R+ +E E + ERE
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE 1389
Score = 75.1 bits (183), Expect = 6e-13
Identities = 95/460 (20%), Positives = 188/460 (40%), Gaps = 65/460 (14%)
Query: 203 QSLQNQHTNALKRCEEVAK--ETDFYHTLHSR-LLSDQTRLKD---DVDMLRRENGQLLR 256
Q LQ + L+R E K E + H R L ++ RL+ + L+ E +
Sbjct: 1343 QLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQ 1402
Query: 257 ERNLLQQSWEDMKRLHEEDQKEIG------DLRAQQQQVLKHNGSSEILNKLYDTAMDKL 310
ER QQ +D R E+++++ R ++QQV + + L + ++
Sbjct: 1403 ERE--QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460
Query: 311 EVVKKDYDALRKRYSEKVAIHNADLSRLEQ----LGEENQRLLKQTEMLTQQRDTAIQLQ 366
+++ L++R +++ D LE+ +E R ++ E+ +Q+ +
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE------ 1514
Query: 367 HQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERD 426
R+F +L++ Q K LQ E +L + E + R R++RD
Sbjct: 1515 -------RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR-------------RQDRD 1554
Query: 427 AVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQ------- 479
+ E + + ER++ + + L E K++ E+K +E + RQ
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR 1614
Query: 480 ------IKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEAD-VAKCRRDWAFQERDK 532
++ + R +++ + K L +E + QE + + RD F+E ++
Sbjct: 1615 QERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQ 1674
Query: 533 IVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRK---QKNDVSRELKELKEQMESQ 589
++ E + + R+ERDR E + LR + RK ++ + R+ E K + E Q
Sbjct: 1675 LLQEGEEQQL----RRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQ 1730
Query: 590 LEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETED 629
L +E QL + ++ + + E E + R+ D
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD 1770
Score = 67.0 bits (162), Expect = 2e-10
Identities = 90/425 (21%), Positives = 182/425 (42%), Gaps = 64/425 (15%)
Query: 232 RLLSDQTRLKDDVDMLRRENGQLLRERN--LLQQSWEDMKRLHEEDQ--KEIGDLRAQQQ 287
+ L ++ +L+ + RE QLL+ER L + D K L EE Q ++ D + ++Q
Sbjct: 1447 KFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ 1506
Query: 288 QVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQR 347
++ + L + + + RK E+ + + R +Q ++ R
Sbjct: 1507 ELRSQEPERKFLEEEQQLHRQQRQ---------RKFLQEEQQLRRQE--RGQQRRQDRDR 1555
Query: 348 LLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSE-LTE 406
++ E L Q+R+ QL Q R+F ++ + + K ++ E +L + E +
Sbjct: 1556 KFREEEQLRQEREEQ-QLSRQ--ERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ 1612
Query: 407 LRTTQVKTAKESEK----------YREERDAVYSEYK----------LIMSERDQVISEL 446
LR + + +E E+ +R+ERD + E + + +RD+ E
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672
Query: 447 DKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALC 506
++L E E E +L+ ++K EE + RQ ++ + +E ++ R++ +
Sbjct: 1673 EQLLQEGE--EQQLRRQERDRKFREEEQQLRRQERERKFLQ-----EEQQLRRQELERKF 1725
Query: 507 QELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNL---RRERDRAVSELAEALR 563
+E ++ QE + + RR QER + + E + +R + R+ERDR E + +
Sbjct: 1726 REEEQLRQETEQEQLRR----QERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ 1781
Query: 564 SLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEF 623
++ + + + R+ +E E QL +E +QL WE E ++
Sbjct: 1782 EREEQQLRSQESDRKFRE-----EEQLRQEREEQQLRPQQR------DGKYRWEEEQLQL 1830
Query: 624 ERETE 628
E + +
Sbjct: 1831 EEQEQ 1835
Score = 62.0 bits (149), Expect = 5e-09
Identities = 87/451 (19%), Positives = 186/451 (41%), Gaps = 74/451 (16%)
Query: 203 QSLQNQHTNALKRCEEVAKETD--FYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNL 260
Q L+ Q+ ++ EE+ +E + R ++ R + + L++E QLLRE
Sbjct: 1074 QELERQY----RKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE 1129
Query: 261 LQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDAL 320
++ E ++ EE+ +++ +++Q+L+ +L ++ E+ +++ L
Sbjct: 1130 KRRRQELERQYREEE-----EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL 1184
Query: 321 RKRYSEKVAIHNADLSRLEQL--------------------------------------G 342
R+ ++ E+L G
Sbjct: 1185 REEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKG 1244
Query: 343 EENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQS 402
EN++ + + + R + LQH L ++ E + +++ E +L +
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQH--LLGEQQERDREQERRRWQQRDRHFPEEEQLERE 1302
Query: 403 ELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKS 462
E E + K+ +E + REER E K E D+ E ++L E E E L+
Sbjct: 1303 EQKEAKRRDRKSQEEKQLLREER-----EEKRRRQETDRKFREEEQLLQERE--EQPLRR 1355
Query: 463 STSEKKAANEEMEALRQIKDTVTMD--AGRANKEVEILRKQCKALCQELKEAL------- 513
++K EE+ Q + + + R +E + L+++ + CQE ++ L
Sbjct: 1356 QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415
Query: 514 ---QEADVAKCRRDWAFQERDKIVAERDSIRTLCD---NLRRERDRAVSELAEALRSLDD 567
+E +++ RD F+E ++ V ++ R + LR+ER R E + L+ ++
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREE 1475
Query: 568 TRKQKNDVSRELKELKEQMESQLEKEARFRQ 598
+ + + R+ E ++Q+ Q E++ +FR+
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQ-ERDRKFRE 1505
Score = 59.7 bits (143), Expect = 3e-08
Identities = 94/443 (21%), Positives = 186/443 (41%), Gaps = 36/443 (8%)
Query: 202 LQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQT--RLKDDVDMLRRENGQLLRERN 259
LQ + Q L+ EE ++ + R +Q RL+ + LRR+ + RE+
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE-QQLRRKQEEERREQQ 318
Query: 260 LLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDA 319
++ E +R +++++ LR +Q++ + E + + + + + ++
Sbjct: 319 --EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ 376
Query: 320 LRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAI 379
LR+ E+ L R +QL E Q +Q QQ QL+ + L + E
Sbjct: 377 LRR---EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 380 HHELNKATAQNKDLQWEME-----LLQSELTEL-----RTTQVKTAKESEKYR------- 422
H + ++ + + L+ E E L + E TE R Q+K +E E+
Sbjct: 434 HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 423 -EERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIK 481
E R+ + + E+++ + K Q E E + +L+S ++ E E L + +
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553
Query: 482 DTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIR 541
+ ++ R +E + R+Q + Q LK +E + +R+ +ER + +R+ +
Sbjct: 554 EEKRLEQER--REQRLKREQEERRDQLLKRE-EERRQQRLKREQ--EERLEQRLKREEVE 608
Query: 542 TLCDNLRRERDRAVSELAEA-----LRSLDDTRKQKNDVSRELKELKEQMESQLEKEARF 596
L RRE+ E E L+S + +++ + RE +E +EQ + E+E R
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668
Query: 597 RQLMAHSSHDSAIDTDSMEWETE 619
Q + + + + E E E
Sbjct: 669 EQRLKREHEEERREQELAEEEQE 691
Score = 59.7 bits (143), Expect = 3e-08
Identities = 91/387 (23%), Positives = 170/387 (43%), Gaps = 66/387 (17%)
Query: 241 KDDVDMLRRENGQLLRERNLLQQSWEDMKR---LHEED---QKEIGDLRAQQQQVLKHNG 294
+ D D RE QL +ER Q S ++ R L E+ Q++ +QQ+ + G
Sbjct: 1550 RQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEG 1609
Query: 295 SSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLE------------QLG 342
++ ++ ++D L++R +++ D LE QL
Sbjct: 1610 QQQL-------RQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR 1662
Query: 343 EENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQS 402
+ R ++ E L Q+ + QL+ Q R+F +L + + K LQ E +L +
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQ-QLRRQ--ERDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719
Query: 403 ELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKS 462
EL + +E E+ R+E + + +L ER + I E ++L+ E E E +L+
Sbjct: 1720 ELE-------RKFREEEQLRQETE----QEQLRRQERYRKILEEEQLRPERE--EQQLRR 1766
Query: 463 STSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCR 522
++K EE LRQ ++ + + ++++ R++ ++L++ +E + +
Sbjct: 1767 QERDRKFREEEQ--LRQEREEQQLRSQESDRK---FREE-----EQLRQEREEQQLRPQQ 1816
Query: 523 RDWAFQ-ERDKIVAERDSIRTLCDNLRRERD---RAVSELAEALRS------LDDTRKQK 572
RD ++ E +++ E R LR+ERD RA + A +S L +QK
Sbjct: 1817 RDGKYRWEEEQLQLEEQEQR-----LRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871
Query: 573 NDVSRELKELKEQMESQLEKEARFRQL 599
RE K +E + Q ++E R RQ+
Sbjct: 1872 RRQERERKLREEHIRRQQKEEQRHRQV 1898
Score = 58.9 bits (141), Expect = 5e-08
Identities = 101/485 (20%), Positives = 202/485 (41%), Gaps = 64/485 (13%)
Query: 144 EKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRAMSDLQ 203
E+ E QLR +ER E R + ++R RL ++E + + A + +
Sbjct: 638 EQEERRQQQLRREQQERREQRLKREEE------EERLEQRLKREHEEERREQELAEEEQE 691
Query: 204 SLQNQHTNALKR------CEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLL-- 255
+ + + + + E A+++ Y R Q R ++ + RR +L
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYS--RPRKQEGQRRRQEQEEKRRRRESELQWQ 749
Query: 256 -RERNLLQQSWEDMKR-----LHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDK 309
ER QQ E+ +R E++ E G R + L+ ++ + +
Sbjct: 750 EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQR 809
Query: 310 L--EVVKKDYDALRKRYSEKVAIHNADLSRLE------QLGEENQRLLKQTEMLT---QQ 358
E +K+ ++R EK + +L+ QL EE L + E Q+
Sbjct: 810 FLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869
Query: 359 RDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKES 418
RD + Q + RR H L A + L+ E +LLQ E EL+ +
Sbjct: 870 RDQKWRWQLEEERKRRR-----HTLYAKPALQEQLRKEQQLLQEEEEELQREE-----RE 919
Query: 419 EKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALR 478
++ R+E++ Y E + + E +Q++ E + E + + + +KK +E + L
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLLRE----EREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 479 QIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDW--AFQERDKIVAE 536
+ + R +E E ++ + L QE ++ L+E + R++W ++++D++ E
Sbjct: 976 EEPEK------RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Query: 537 RDSIRTLCDNLRRERD-RAVSELAEALRSLDDTRKQKNDVSRELKEL--KEQMESQLEKE 593
+ + LR ER+ R + E R ++ ++++ + E +E ++++E Q KE
Sbjct: 1030 EEQL------LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKE 1083
Query: 594 ARFRQ 598
+Q
Sbjct: 1084 EELQQ 1088
Score = 57.0 bits (136), Expect = 2e-07
Identities = 94/417 (22%), Positives = 170/417 (40%), Gaps = 30/417 (7%)
Query: 206 QNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSW 265
Q + LKR +E + D+ +Q R K L+R+ + RER L +
Sbjct: 440 QERREQRLKREQE--ERRDWLKREEETERHEQERRKQQ---LKRDQEEERRERWLKLEEE 494
Query: 266 EDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYS 325
E ++ +Q+ + +++Q LK E L + + ++ + L KR
Sbjct: 495 ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREE 554
Query: 326 EKVAIHNADLSRLEQLGEENQ-RLLKQTEMLTQQ---RDTAIQLQHQCAL-SLRRFEAIH 380
EK RL++ EE + +LLK+ E QQ R+ +L+ + + R E
Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEE 614
Query: 381 HELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKL---IMS 437
+ + + + +LL+SE E R Q ++ E+ + E +L +
Sbjct: 615 RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR 674
Query: 438 ERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIK--DTVTMDAG---RAN 492
E ++ E + + E E A ++KS + + E RQ K G R
Sbjct: 675 EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE 734
Query: 493 KEVEILRKQCKALCQELKEALQEADVAKCRRD----WAFQERDKIVAERDSIRTLCDNLR 548
+E + R++ + QE + A ++ + RRD W +E+ + +R S R R
Sbjct: 735 QEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQR 794
Query: 549 RERDRAVSELAEALRSL------DDTRKQKNDVSRELKELKEQMESQLEKEARFRQL 599
+ RA R L + R+Q+ + +EL+ L+E E QL++ R +QL
Sbjct: 795 ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE--EEQLQRRERAQQL 849
Score = 55.5 bits (132), Expect = 5e-07
Identities = 98/435 (22%), Positives = 177/435 (40%), Gaps = 73/435 (16%)
Query: 245 DMLRRENGQLLRERNLLQQSWEDMKRL-HEEDQKEIGDLRAQQQQVLKHNGSSEILNKLY 303
+ R+ LR+R QS +D++ L E+ +++ R + QQ +H E L +
Sbjct: 1248 EQFRQLEDSQLRDR----QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLER-- 1301
Query: 304 DTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAI 363
++ E ++D RK EK + + + +E R ++ E L Q+R+
Sbjct: 1302 ---EEQKEAKRRD----RKSQEEKQLLREEREEKRRR--QETDRKFREEEQLLQEREEQP 1352
Query: 364 QLQHQCALSLRRFEAIHHE-----------LNKATAQNKDLQWEMEL-LQSELTELRTTQ 411
+ + R E H E L + + K L+ E +L Q +LR +
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDR 1412
Query: 412 VKTAKESE----------KYREERDAV---------YSEYKLIMSERDQVISELDKLQTE 452
+ +E E K+REE V E + + ER + E ++L E
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472
Query: 453 VELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVE-----------ILRKQ 501
E E +L ++K EE + RQ +D + ++E E ++Q
Sbjct: 1473 RE--EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530
Query: 502 CKALCQELKEALQEADVAKCR-RDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAE 560
K L +E + QE + + RD F+E +++ ER+ + R+ERDR +
Sbjct: 1531 RKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQL----SRQERDRKFRLEEQ 1586
Query: 561 ALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFR---QLMAHSS----HDSAIDTDS 613
+R + RK D ++L+ + Q + + E++ +FR QL+ H D
Sbjct: 1587 KVRRQEQERKFMED-EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF 1645
Query: 614 MEWETEVVEFERETE 628
+E E ++ ERE +
Sbjct: 1646 LEEEPQLRRQEREQQ 1660
Score = 45.4 bits (106), Expect = 5e-04
Identities = 55/264 (20%), Positives = 108/264 (40%), Gaps = 21/264 (7%)
Query: 374 RRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYK 433
RRFE +L + Q + + + + + EL E K + ++ R+ RD +
Sbjct: 120 RRFEPRDRQLEEEPGQRRRQKRQEQ--ERELAEGEEQSEKQERLEQRDRQRRDEELWRQR 177
Query: 434 LIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANK 493
ER++ +E ++LQ+ + + E++ E+ LR+ GR K
Sbjct: 178 QEWQEREERRAEEEQLQS---CKGHETEEFPDEEQLRRRELLELRR--------KGREEK 226
Query: 494 EVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERD-----KIVAERDSIRTL-CDNL 547
+ + +Q + +E ++ ++ + + + QE + ++ E + +R L L
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286
Query: 548 RRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDS 607
RRER + R RKQ+ + + +E +EQ E + ++E R Q + +
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER 346
Query: 608 AIDTDSMEWETEVVE--FERETED 629
E E E E RE E+
Sbjct: 347 REQQLRREQEEERREQQLRREQEE 370
Score = 43.1 bits (100), Expect = 0.003
Identities = 71/392 (18%), Positives = 160/392 (40%), Gaps = 57/392 (14%)
Query: 256 RERNLLQQSWEDMKRLHEEDQKEI--GDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVV 313
R+R L ++ + ++ +E ++E+ G+ ++++Q+ L+ +L+
Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQ-------- 176
Query: 314 KKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSL 373
++++ +R +E+ + + E+ +E Q L++ E+L +R + Q Q
Sbjct: 177 RQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ--LRRRELLELRRKGREEKQQQRRERQ 234
Query: 374 -------------RRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEK 420
+R + E K + Q E++ + +L +L +++ ++ E+
Sbjct: 235 DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEE 294
Query: 421 YREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEM--EALR 478
+++R R+Q +L + Q E + + + E++ EE + LR
Sbjct: 295 QQQQR-----------LRREQ---QLRRKQEEERREQQEERREQQERREQQEERREQQLR 340
Query: 479 QIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERD 538
+ ++ R +E E +Q + +E + Q + RR+ + ++ E+
Sbjct: 341 REQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ 400
Query: 539 SIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQ 598
R LRRE+ + LR R+++ + E K +E+ E +L++E R+
Sbjct: 401 LRRE--QQLRREQQ---LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455
Query: 599 LMAHSSHDSAIDTDSMEWETEVVEFERETEDI 630
D E ETE E ER + +
Sbjct: 456 -----------DWLKREEETERHEQERRKQQL 476
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 80.9 bits (198), Expect = 1e-14
Identities = 87/421 (20%), Positives = 191/421 (45%), Gaps = 39/421 (9%)
Query: 239 RLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEI 298
+L+D++ ++ +N +L +ER LL++ D+ E++++ +L + + E+
Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 299 LNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLE-QLG---EENQRLLKQTEM 354
K + + +LE +K+ + + E++A A ++ L+ QL EE Q L + +
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1101
Query: 355 LTQQRDTAI----QLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTT 410
Q++ A+ +L+ + ++ NKA Q +DL E+E L+ TEL T
Sbjct: 1102 EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK---TELEDT 1158
Query: 411 QVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAA 470
TA + E + V K + E +++ +++ + A +L + K A
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1218
Query: 471 NEEMEALRQIKDTVTMD-------AGRANKEVEILRKQCKALCQELKEALQEADVAKCRR 523
++ +Q + D G+A +EVE +K+ +A QEL+ + + A+
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA-- 1276
Query: 524 DWAFQERDKIVAERDSIRTLCDNLRRERDRAV----------SELAEALRSLDDTRKQKN 573
+ DK+ ++ + ++ L +A+ S+L + L + +QK
Sbjct: 1277 ----ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1332
Query: 574 DVSRELKELKEQ---MESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDI 630
+VS +L++L+E+ ++ QL++E +Q + H S ++ + + ++ +F E +
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDEEMEAKQNL--ERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 631 D 631
+
Sbjct: 1391 E 1391
Score = 76.3 bits (186), Expect = 3e-13
Identities = 83/399 (20%), Positives = 177/399 (44%), Gaps = 75/399 (18%)
Query: 237 QTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSS 296
Q + ++++ L +++ QL E+NLLQ+ + L+ E ++ L A++Q++
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL------E 921
Query: 297 EILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLT 356
EIL+++ + +++ E + A RK+ + Q++L E L
Sbjct: 922 EILHEM-EARLEEEEDRGQQLQAERKKMA--------------------QQMLDLEEQLE 960
Query: 357 QQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAK 416
++ +LQ + + + + + E+ QN L E +LL+ +++L T
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN------ 1014
Query: 417 ESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEA 476
++E ++ L KL+ + E S+L+ +++ + +E+E
Sbjct: 1015 -------------------LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE- 1054
Query: 477 LRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAE 536
++K + DA ++++ L+ Q L +L + +E A R D D+I +
Sbjct: 1055 --KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD------DEIAQK 1106
Query: 537 RDSIRTLCDNLRRERDRAVSELAEALRS----LDDTRKQKNDVSRELKELKEQMESQLEK 592
++++ + RE + +S+L E L S + KQK D+ EL+ LK ++E L+
Sbjct: 1107 NNALKKI-----RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1161
Query: 593 EARFRQLMAHSSHD-----SAIDTDSMEWETEVVEFERE 626
A ++L A + A+D ++ E +V E ++
Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Score = 75.9 bits (185), Expect = 4e-13
Identities = 108/521 (20%), Positives = 223/521 (42%), Gaps = 43/521 (8%)
Query: 137 LTDQ--QVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQ 194
LT+Q Q NL + + +E +L L + +L + L+ +
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 195 CV---RAMSDLQSLQNQHTNALKRCEEVAKETDFYHT-LHSRLLSDQTRLKDDVDMLRRE 250
C RA ++L ++ N ++ + E + L + S ++L+D ++L+ E
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327
Query: 251 NGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGS-SEILNKLYDTA--M 307
Q L L+Q E+ L ++ +E+ + ++ + N S+ KL D A +
Sbjct: 1328 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 308 DKLEVVKKDY----DALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAI 363
+ LE KK + + L ++Y EK A + ++L + RL ++ + L D
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEKAAAY-------DKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 364 QLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYRE 423
QL R+F+ + E +++ D E + ++E E T + A+ E+ E
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYAD---ERDRAEAEAREKETKALSLARALEEALE 1497
Query: 424 ERDAVYSEYKLIMSERDQVISELDKLQTEV-ELAESK--LKSSTSEKKAANEEME-ALRQ 479
++ + K++ +E + ++S D + V EL +SK L++ E K EE+E L+
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 480 IKDT-----VTMDA--GRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDK 532
+D V M A G+ ++++ +Q + ++L+ L E + + ++R
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET---ELEDERKQRAL 1614
Query: 533 IVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEK 592
A + + +L + D A+ EA++ L + Q D REL+ +++ +
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE------DARASR 1668
Query: 593 EARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLK 633
+ F + +++ D M+ + ++ ER + DL+
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Score = 73.9 bits (180), Expect = 1e-12
Identities = 110/490 (22%), Positives = 215/490 (43%), Gaps = 67/490 (13%)
Query: 140 QQVNEKVENLSIQLRLMTRERNELRK---RLAFATHGTAFDKRPYHRLNPDYERLKIQCV 196
++ +++ENL+ Q ++L K RL D +L + E+ + +
Sbjct: 1395 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 197 RAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLR 256
+ +++ +++ +++ + R E A+E + +R L + K++ L R N L
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE---LERTNKMLKA 1511
Query: 257 ERNLLQQSWEDM-KRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKK 315
E L S +D+ K +HE ++ + RA + Q+ + E L D ++
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSK----RALETQMEEMKTQLEELEDELQATEDAKLRLEV 1567
Query: 316 DYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLK------QTEMLTQQRDTAI------ 363
+ AL+ ++ DL ++ EE +R L+ +TE+ +++ A+
Sbjct: 1568 NMQALKGQFER-------DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1620
Query: 364 -------QLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAK 416
L+ Q +++ E +L K AQ KD Q E+E ++ E+ TAK
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI----FATAK 1676
Query: 417 ESEKYRE--ERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEM 474
E+EK + E D + + L +ER + ++L+K ELAE +L SS S + A +E
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEK----EELAE-ELASSLSGRNALQDE- 1730
Query: 475 EALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIV 534
K + + +E+E + +A+ +++A Q+A+ Q +++
Sbjct: 1731 ------KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE----------QLSNELA 1774
Query: 535 AERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELK-EQMESQLEKE 593
ER + + ++ R++ +R EL L ++ K K + E K Q+E Q+E+E
Sbjct: 1775 TERSTAQK-NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 594 ARFRQLMAHS 603
AR +Q S
Sbjct: 1834 AREKQAATKS 1843
Score = 70.5 bits (171), Expect = 2e-11
Identities = 151/715 (21%), Positives = 289/715 (40%), Gaps = 143/715 (20%)
Query: 4 QRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLD----------EEAGGAKA 53
+ R LA +Q L + + E+EA L E G ER+++ EE A+
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 967
Query: 54 ELLLKLLLAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLST-MP 112
+L L+ + A+ A ++K + +L + N + + S L+T +
Sbjct: 968 KLQLEKVTAE---------AKIKKLEDEILVMDDQNNKLSKERKL--LEERISDLTTNLA 1016
Query: 113 SDSESSSSLSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATH 172
+ E + +L+ + + + L ++L+ + R EL K L
Sbjct: 1017 EEEEKAKNLTKL--------------KNKHESMISELEVRLKKEEKSRQELEK-LKRKLE 1061
Query: 173 GTAFDKRPYHR----LNPDYERLKIQCVRAMSDLQSLQ-------NQHTNALKRCEEVAK 221
G A D +H L LK+Q + +LQ+ Q NALK+ E+
Sbjct: 1062 GDASD---FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 222 ETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEE------D 275
+SD L++D+D R + +++ L + E +K E+
Sbjct: 1119 H-----------ISD---LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1164
Query: 276 QKEIGDLRAQQQQVLK---------HNGSSEILNKLYDTAMDKLEVVKKDYDALR---KR 323
Q+E+ R Q+ VLK H + + + + A+++L + + + +
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 324 YSEKVAIHNADLS-RLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHE 382
+ + NADL+ L LG+ Q + + + L Q +LQ +C+ R ++ +
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ---VQELQSKCSDGERARAELNDK 1281
Query: 383 LNKATAQNKDLQWEMELLQSELTELRTTQVKTAKE----SEKYREERDAVYSE--YKLIM 436
++K LQ E+E + L E +K AK+ S + ++ ++ + E KL +
Sbjct: 1282 VHK-------LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 437 SERDQVISE-----LDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTV-TMDAGR 490
S + + + E D+L E+E ++ + ++ ++ + L+ TV ++ G+
Sbjct: 1335 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1394
Query: 491 ANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRR- 549
+K+ + L Q+ +E D + ++ QE D +V + D+ R L NL +
Sbjct: 1395 KR-----FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 550 --------------------ERDRAVSELAE-------ALRSLDDTRKQKNDVSRELKEL 582
ERDRA +E E R+L++ + K ++ R K L
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 583 KEQMESQL-EKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERE---TEDIDLK 633
K +ME + K+ + + A++T E +T++ E E E TED L+
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Score = 58.9 bits (141), Expect = 5e-08
Identities = 107/508 (21%), Positives = 199/508 (39%), Gaps = 56/508 (11%)
Query: 140 QQVNEKVENLSIQLRLMTRERNELRKR---LAFATHGTAFDKRPYHRLNPDYERLKIQCV 196
Q+ + VE L+ QL R + L K L A + R + + E K +
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 197 RAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQ--- 253
+ +LQS + A A+ D H L Q ++ ML G+
Sbjct: 1259 AQVQELQSKCSDGERAR------AELNDKVHKL-------QNEVESVTGMLNEAEGKAIK 1305
Query: 254 LLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVV 313
L ++ L +D + L +E+ ++ ++ + +Q+ + S L D M+ + +
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS---LQDQLDEEMEAKQNL 1362
Query: 314 KKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSL 373
++ L + S+ S +E L E +R K+ E LTQQ + + +
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 374 RRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYK 433
R + +L + L +E Q + +L + S KY +ERD +E +
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI---SSKYADERDRAEAEAR 1479
Query: 434 LIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANK 493
E++ L + E A+ +L+ + KA EME L KD D G+
Sbjct: 1480 ----EKETKALSLARALEEALEAKEELERTNKMLKA---EMEDLVSSKD----DVGKNVH 1528
Query: 494 EVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDR 553
E+E ++ + +E+K L+E + D++ A D+ L N++ +
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELE-------------DELQATEDAKLRLEVNMQALK-- 1573
Query: 554 AVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDS 613
+ L++ D+ ++K R+L+ + E++LE E + R L A + D
Sbjct: 1574 --GQFERDLQARDEQNEEKR---RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 614 MEWETEVVEFERETEDIDLKALGFDMAE 641
+E + + RE L+ L M +
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKD 1656
Score = 58.9 bits (141), Expect = 5e-08
Identities = 92/478 (19%), Positives = 188/478 (39%), Gaps = 53/478 (11%)
Query: 116 ESSSSLSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTA 175
E+ L KA + + V + V L R + + E++ +L
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-------- 1548
Query: 176 FDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLS 235
L + + + +R ++Q+L+ Q L+ +E +E L +L
Sbjct: 1549 ------EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR--RQLQRQLHE 1600
Query: 236 DQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMK-------RLHEEDQKEIGDLRAQQQQ 288
+T L+D+ R++ + L+ +D++ + EE K++ L+AQ +
Sbjct: 1601 YETELEDE----RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK- 1655
Query: 289 VLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRL 348
+ +L D + E+ A K +K ADL +L++ +R
Sbjct: 1656 --------DFQRELEDARASRDEIF-----ATAKENEKKAKSLEADLMQLQEDLAAAERA 1702
Query: 349 LKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELR 408
KQ ++ ++ L + A SL A+ E + A+ L+ E+E Q + +
Sbjct: 1703 RKQADLEKEE------LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 409 TTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKK 468
K +++E+ E S + S R Q+ + +L++++ E +KS
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 469 AANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQ 528
AA E A Q+++ V +A +E + K K ++LKE L + + + + +
Sbjct: 1817 AALEAKIA--QLEEQVEQEA----REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1870
Query: 529 ERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQM 586
+ +K A ++ + E R + + R LD+ + + RE+ LK ++
Sbjct: 1871 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 49.3 bits (116), Expect = 4e-05
Identities = 65/330 (19%), Positives = 128/330 (38%), Gaps = 46/330 (13%)
Query: 311 EVVKKDYDALRKRYSEKVAIHNADLSRLEQ----LGEENQRLLKQTEMLTQQRDTAIQLQ 366
E ++ D L+K + N +L LEQ L EE L +Q + T+ A +++
Sbjct: 852 EEMQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 367 HQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERD 426
+ A + E I HE+ + +D +++ + ++ + + +E E R+
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ--- 967
Query: 427 AVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSE---KKAANEEMEALRQIKDT 483
KLQ E AE+K+K E N ++ R++ +
Sbjct: 968 ---------------------KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 484 VTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERD----- 538
D E E K L + + + E +V + + + QE +K+ + +
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Query: 539 ------SIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELK---EQMESQ 589
++ L+ + + EL AL LDD QKN+ ++++EL+ ++
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 590 LEKEARFRQLMAHSSHDSAIDTDSMEWETE 619
L+ E R D + ++++ E E
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELE 1156
Score = 43.5 bits (101), Expect = 0.002
Identities = 61/299 (20%), Positives = 136/299 (45%), Gaps = 46/299 (15%)
Query: 357 QQRDTAIQ-LQHQCALSLR-------RFEAIHHELNKATAQNKDLQWEMELLQSELTELR 408
QQ+ TA++ +Q CA L+ R L + T Q + EM+ + EL + +
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEE----EMQAKEDELQKTK 865
Query: 409 TTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVEL-AESK-LKSSTSE 466
Q K E ++ ++ + E L+ ++LQ E EL AE++ ++ +
Sbjct: 866 ERQQKAENELKELEQKHSQLTEEKNLLQ----------EQLQAETELYAEAEEMRVRLAA 915
Query: 467 KKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWA 526
KK EE+ L +++ + + R ++++ RK+ +L+E L+E + A+ +
Sbjct: 916 KKQELEEI--LHEMEARLEEEEDR-GQQLQAERKKMAQQMLDLEEQLEEEEAARQK---- 968
Query: 527 FQERDKIVAE------RDSIRTLCD---NLRRER---DRAVSELAEALRSLDDTRKQKND 574
+ +K+ AE D I + D L +ER + +S+L L ++ K
Sbjct: 969 -LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027
Query: 575 VSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLK 633
+ + + + ++E +L+KE + RQ + ++ D+ ++ ++ + + + ++ ++
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKR--KLEGDASDFHEQIADLQAQIAELKMQ 1084
Score = 37.7 bits (86), Expect = 0.11
Identities = 78/374 (20%), Positives = 138/374 (36%), Gaps = 64/374 (17%)
Query: 139 DQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQC--- 195
D+Q EK L QL E + RK+ A A +L D + L++Q
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK-------KLEGDLKDLELQADSA 1636
Query: 196 ----VRAMSDLQSLQNQHTNALKRCEEV-AKETDFYHTLHSR------LLSDQTRLKDDV 244
A+ L+ LQ Q + + E+ A + + T L +D +L++D+
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 245 --------------DMLRRENGQLLRERNLLQQSWEDMK----RLHEEDQKEIGDLRAQQ 286
+ L E L RN LQ ++ +L EE ++E G++ A
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 287 QQVLKHNGSSEILNKLYDT---AMDKLEVVKKDYDALRKRYSEKV-----AIHNADLSRL 338
+V K +E L+ T K E ++ + K K+ A+ + S +
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 339 EQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEME 398
L + +L +Q E +++ A + Q L+ + K Q K+
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE------ 1870
Query: 399 LLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAES 458
Q+E R Q+K E + +R I + R ++ ELD+ E
Sbjct: 1871 --QAEKGNARVKQLKRQLEEAEEESQR---------INANRRKLQRELDEATESNEAMGR 1919
Query: 459 KLKSSTSEKKAANE 472
++ + S+ + NE
Sbjct: 1920 EVNALKSKLRRGNE 1933
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 80.9 bits (198), Expect = 1e-14
Identities = 87/421 (20%), Positives = 191/421 (45%), Gaps = 39/421 (9%)
Query: 239 RLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEI 298
+L+D++ ++ +N +L +ER LL++ D+ E++++ +L + + E+
Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 299 LNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLE-QLG---EENQRLLKQTEM 354
K + + +LE +K+ + + E++A A ++ L+ QL EE Q L + +
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1108
Query: 355 LTQQRDTAI----QLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTT 410
Q++ A+ +L+ + ++ NKA Q +DL E+E L+ TEL T
Sbjct: 1109 EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK---TELEDT 1165
Query: 411 QVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAA 470
TA + E + V K + E +++ +++ + A +L + K A
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1225
Query: 471 NEEMEALRQIKDTVTMD-------AGRANKEVEILRKQCKALCQELKEALQEADVAKCRR 523
++ +Q + D G+A +EVE +K+ +A QEL+ + + A+
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA-- 1283
Query: 524 DWAFQERDKIVAERDSIRTLCDNLRRERDRAV----------SELAEALRSLDDTRKQKN 573
+ DK+ ++ + ++ L +A+ S+L + L + +QK
Sbjct: 1284 ----ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1339
Query: 574 DVSRELKELKEQ---MESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDI 630
+VS +L++L+E+ ++ QL++E +Q + H S ++ + + ++ +F E +
Sbjct: 1340 NVSTKLRQLEEERNSLQDQLDEEMEAKQNL--ERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 631 D 631
+
Sbjct: 1398 E 1398
Score = 76.3 bits (186), Expect = 3e-13
Identities = 83/399 (20%), Positives = 177/399 (44%), Gaps = 75/399 (18%)
Query: 237 QTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSS 296
Q + ++++ L +++ QL E+NLLQ+ + L+ E ++ L A++Q++
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL------E 928
Query: 297 EILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLT 356
EIL+++ + +++ E + A RK+ + Q++L E L
Sbjct: 929 EILHEM-EARLEEEEDRGQQLQAERKKMA--------------------QQMLDLEEQLE 967
Query: 357 QQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAK 416
++ +LQ + + + + + E+ QN L E +LL+ +++L T
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN------ 1021
Query: 417 ESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEA 476
++E ++ L KL+ + E S+L+ +++ + +E+E
Sbjct: 1022 -------------------LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE- 1061
Query: 477 LRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAE 536
++K + DA ++++ L+ Q L +L + +E A R D D+I +
Sbjct: 1062 --KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD------DEIAQK 1113
Query: 537 RDSIRTLCDNLRRERDRAVSELAEALRS----LDDTRKQKNDVSRELKELKEQMESQLEK 592
++++ + RE + +S+L E L S + KQK D+ EL+ LK ++E L+
Sbjct: 1114 NNALKKI-----RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1168
Query: 593 EARFRQLMAHSSHD-----SAIDTDSMEWETEVVEFERE 626
A ++L A + A+D ++ E +V E ++
Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Score = 75.9 bits (185), Expect = 4e-13
Identities = 108/521 (20%), Positives = 223/521 (42%), Gaps = 43/521 (8%)
Query: 137 LTDQ--QVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQ 194
LT+Q Q NL + + +E +L L + +L + L+ +
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Query: 195 CV---RAMSDLQSLQNQHTNALKRCEEVAKETDFYHT-LHSRLLSDQTRLKDDVDMLRRE 250
C RA ++L ++ N ++ + E + L + S ++L+D ++L+ E
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334
Query: 251 NGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGS-SEILNKLYDTA--M 307
Q L L+Q E+ L ++ +E+ + ++ + N S+ KL D A +
Sbjct: 1335 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 308 DKLEVVKKDY----DALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAI 363
+ LE KK + + L ++Y EK A + ++L + RL ++ + L D
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEKAAAY-------DKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 364 QLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYRE 423
QL R+F+ + E +++ D E + ++E E T + A+ E+ E
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYAD---ERDRAEAEAREKETKALSLARALEEALE 1504
Query: 424 ERDAVYSEYKLIMSERDQVISELDKLQTEV-ELAESK--LKSSTSEKKAANEEME-ALRQ 479
++ + K++ +E + ++S D + V EL +SK L++ E K EE+E L+
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 480 IKDT-----VTMDA--GRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDK 532
+D V M A G+ ++++ +Q + ++L+ L E + + ++R
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET---ELEDERKQRAL 1621
Query: 533 IVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEK 592
A + + +L + D A+ EA++ L + Q D REL+ +++ +
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE------DARASR 1675
Query: 593 EARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLK 633
+ F + +++ D M+ + ++ ER + DL+
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Score = 73.9 bits (180), Expect = 1e-12
Identities = 110/490 (22%), Positives = 215/490 (43%), Gaps = 67/490 (13%)
Query: 140 QQVNEKVENLSIQLRLMTRERNELRK---RLAFATHGTAFDKRPYHRLNPDYERLKIQCV 196
++ +++ENL+ Q ++L K RL D +L + E+ + +
Sbjct: 1402 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 197 RAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLR 256
+ +++ +++ +++ + R E A+E + +R L + K++ L R N L
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE---LERTNKMLKA 1518
Query: 257 ERNLLQQSWEDM-KRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKK 315
E L S +D+ K +HE ++ + RA + Q+ + E L D ++
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSK----RALETQMEEMKTQLEELEDELQATEDAKLRLEV 1574
Query: 316 DYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLK------QTEMLTQQRDTAI------ 363
+ AL+ ++ DL ++ EE +R L+ +TE+ +++ A+
Sbjct: 1575 NMQALKGQFER-------DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1627
Query: 364 -------QLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAK 416
L+ Q +++ E +L K AQ KD Q E+E ++ E+ TAK
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI----FATAK 1683
Query: 417 ESEKYRE--ERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEM 474
E+EK + E D + + L +ER + ++L+K ELAE +L SS S + A +E
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEK----EELAE-ELASSLSGRNALQDE- 1737
Query: 475 EALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIV 534
K + + +E+E + +A+ +++A Q+A+ Q +++
Sbjct: 1738 ------KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE----------QLSNELA 1781
Query: 535 AERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELK-EQMESQLEKE 593
ER + + ++ R++ +R EL L ++ K K + E K Q+E Q+E+E
Sbjct: 1782 TERSTAQK-NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 594 ARFRQLMAHS 603
AR +Q S
Sbjct: 1841 AREKQAATKS 1850
Score = 70.5 bits (171), Expect = 2e-11
Identities = 151/715 (21%), Positives = 289/715 (40%), Gaps = 143/715 (20%)
Query: 4 QRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLD----------EEAGGAKA 53
+ R LA +Q L + + E+EA L E G ER+++ EE A+
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 974
Query: 54 ELLLKLLLAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLST-MP 112
+L L+ + A+ A ++K + +L + N + + S L+T +
Sbjct: 975 KLQLEKVTAE---------AKIKKLEDEILVMDDQNNKLSKERKL--LEERISDLTTNLA 1023
Query: 113 SDSESSSSLSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATH 172
+ E + +L+ + + + L ++L+ + R EL K L
Sbjct: 1024 EEEEKAKNLTKL--------------KNKHESMISELEVRLKKEEKSRQELEK-LKRKLE 1068
Query: 173 GTAFDKRPYHR----LNPDYERLKIQCVRAMSDLQSLQ-------NQHTNALKRCEEVAK 221
G A D +H L LK+Q + +LQ+ Q NALK+ E+
Sbjct: 1069 GDASD---FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 222 ETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEE------D 275
+SD L++D+D R + +++ L + E +K E+
Sbjct: 1126 H-----------ISD---LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1171
Query: 276 QKEIGDLRAQQQQVLK---------HNGSSEILNKLYDTAMDKLEVVKKDYDALR---KR 323
Q+E+ R Q+ VLK H + + + + A+++L + + + +
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 324 YSEKVAIHNADLS-RLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHE 382
+ + NADL+ L LG+ Q + + + L Q +LQ +C+ R ++ +
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ---VQELQSKCSDGERARAELNDK 1288
Query: 383 LNKATAQNKDLQWEMELLQSELTELRTTQVKTAKE----SEKYREERDAVYSE--YKLIM 436
++K LQ E+E + L E +K AK+ S + ++ ++ + E KL +
Sbjct: 1289 VHK-------LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 437 SERDQVISE-----LDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTV-TMDAGR 490
S + + + E D+L E+E ++ + ++ ++ + L+ TV ++ G+
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1401
Query: 491 ANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRR- 549
+K+ + L Q+ +E D + ++ QE D +V + D+ R L NL +
Sbjct: 1402 KR-----FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 550 --------------------ERDRAVSELAE-------ALRSLDDTRKQKNDVSRELKEL 582
ERDRA +E E R+L++ + K ++ R K L
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 583 KEQMESQL-EKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERE---TEDIDLK 633
K +ME + K+ + + A++T E +T++ E E E TED L+
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Score = 58.9 bits (141), Expect = 5e-08
Identities = 107/508 (21%), Positives = 199/508 (39%), Gaps = 56/508 (11%)
Query: 140 QQVNEKVENLSIQLRLMTRERNELRKR---LAFATHGTAFDKRPYHRLNPDYERLKIQCV 196
Q+ + VE L+ QL R + L K L A + R + + E K +
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 197 RAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQ--- 253
+ +LQS + A A+ D H L Q ++ ML G+
Sbjct: 1266 AQVQELQSKCSDGERAR------AELNDKVHKL-------QNEVESVTGMLNEAEGKAIK 1312
Query: 254 LLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVV 313
L ++ L +D + L +E+ ++ ++ + +Q+ + S L D M+ + +
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS---LQDQLDEEMEAKQNL 1369
Query: 314 KKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSL 373
++ L + S+ S +E L E +R K+ E LTQQ + + +
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 374 RRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYK 433
R + +L + L +E Q + +L + S KY +ERD +E +
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI---SSKYADERDRAEAEAR 1486
Query: 434 LIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANK 493
E++ L + E A+ +L+ + KA EME L KD D G+
Sbjct: 1487 ----EKETKALSLARALEEALEAKEELERTNKMLKA---EMEDLVSSKD----DVGKNVH 1535
Query: 494 EVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDR 553
E+E ++ + +E+K L+E + D++ A D+ L N++ +
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELE-------------DELQATEDAKLRLEVNMQALK-- 1580
Query: 554 AVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDS 613
+ L++ D+ ++K R+L+ + E++LE E + R L A + D
Sbjct: 1581 --GQFERDLQARDEQNEEKR---RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 614 MEWETEVVEFERETEDIDLKALGFDMAE 641
+E + + RE L+ L M +
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKD 1663
Score = 58.9 bits (141), Expect = 5e-08
Identities = 92/478 (19%), Positives = 188/478 (39%), Gaps = 53/478 (11%)
Query: 116 ESSSSLSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTA 175
E+ L KA + + V + V L R + + E++ +L
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-------- 1555
Query: 176 FDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLS 235
L + + + +R ++Q+L+ Q L+ +E +E L +L
Sbjct: 1556 ------EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR--RQLQRQLHE 1607
Query: 236 DQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMK-------RLHEEDQKEIGDLRAQQQQ 288
+T L+D+ R++ + L+ +D++ + EE K++ L+AQ +
Sbjct: 1608 YETELEDE----RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK- 1662
Query: 289 VLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRL 348
+ +L D + E+ A K +K ADL +L++ +R
Sbjct: 1663 --------DFQRELEDARASRDEIF-----ATAKENEKKAKSLEADLMQLQEDLAAAERA 1709
Query: 349 LKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELR 408
KQ ++ ++ L + A SL A+ E + A+ L+ E+E Q + +
Sbjct: 1710 RKQADLEKEE------LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 409 TTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKK 468
K +++E+ E S + S R Q+ + +L++++ E +KS
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 469 AANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQ 528
AA E A Q+++ V +A +E + K K ++LKE L + + + + +
Sbjct: 1824 AALEAKIA--QLEEQVEQEA----REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1877
Query: 529 ERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQM 586
+ +K A ++ + E R + + R LD+ + + RE+ LK ++
Sbjct: 1878 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 49.3 bits (116), Expect = 4e-05
Identities = 65/330 (19%), Positives = 128/330 (38%), Gaps = 46/330 (13%)
Query: 311 EVVKKDYDALRKRYSEKVAIHNADLSRLEQ----LGEENQRLLKQTEMLTQQRDTAIQLQ 366
E ++ D L+K + N +L LEQ L EE L +Q + T+ A +++
Sbjct: 859 EEMQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 367 HQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERD 426
+ A + E I HE+ + +D +++ + ++ + + +E E R+
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ--- 974
Query: 427 AVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSE---KKAANEEMEALRQIKDT 483
KLQ E AE+K+K E N ++ R++ +
Sbjct: 975 ---------------------KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 484 VTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERD----- 538
D E E K L + + + E +V + + + QE +K+ + +
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 539 ------SIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELK---EQMESQ 589
++ L+ + + EL AL LDD QKN+ ++++EL+ ++
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 590 LEKEARFRQLMAHSSHDSAIDTDSMEWETE 619
L+ E R D + ++++ E E
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELE 1163
Score = 43.5 bits (101), Expect = 0.002
Identities = 61/299 (20%), Positives = 136/299 (45%), Gaps = 46/299 (15%)
Query: 357 QQRDTAIQ-LQHQCALSLR-------RFEAIHHELNKATAQNKDLQWEMELLQSELTELR 408
QQ+ TA++ +Q CA L+ R L + T Q + EM+ + EL + +
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEE----EMQAKEDELQKTK 872
Query: 409 TTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVEL-AESK-LKSSTSE 466
Q K E ++ ++ + E L+ ++LQ E EL AE++ ++ +
Sbjct: 873 ERQQKAENELKELEQKHSQLTEEKNLLQ----------EQLQAETELYAEAEEMRVRLAA 922
Query: 467 KKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWA 526
KK EE+ L +++ + + R ++++ RK+ +L+E L+E + A+ +
Sbjct: 923 KKQELEEI--LHEMEARLEEEEDR-GQQLQAERKKMAQQMLDLEEQLEEEEAARQK---- 975
Query: 527 FQERDKIVAE------RDSIRTLCD---NLRRER---DRAVSELAEALRSLDDTRKQKND 574
+ +K+ AE D I + D L +ER + +S+L L ++ K
Sbjct: 976 -LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034
Query: 575 VSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLK 633
+ + + + ++E +L+KE + RQ + ++ D+ ++ ++ + + + ++ ++
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKR--KLEGDASDFHEQIADLQAQIAELKMQ 1091
Score = 37.7 bits (86), Expect = 0.11
Identities = 78/374 (20%), Positives = 138/374 (36%), Gaps = 64/374 (17%)
Query: 139 DQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQC--- 195
D+Q EK L QL E + RK+ A A +L D + L++Q
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK-------KLEGDLKDLELQADSA 1643
Query: 196 ----VRAMSDLQSLQNQHTNALKRCEEV-AKETDFYHTLHSR------LLSDQTRLKDDV 244
A+ L+ LQ Q + + E+ A + + T L +D +L++D+
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 245 --------------DMLRRENGQLLRERNLLQQSWEDMK----RLHEEDQKEIGDLRAQQ 286
+ L E L RN LQ ++ +L EE ++E G++ A
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 287 QQVLKHNGSSEILNKLYDT---AMDKLEVVKKDYDALRKRYSEKV-----AIHNADLSRL 338
+V K +E L+ T K E ++ + K K+ A+ + S +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 339 EQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEME 398
L + +L +Q E +++ A + Q L+ + K Q K+
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE------ 1877
Query: 399 LLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAES 458
Q+E R Q+K E + +R I + R ++ ELD+ E
Sbjct: 1878 --QAEKGNARVKQLKRQLEEAEEESQR---------INANRRKLQRELDEATESNEAMGR 1926
Query: 459 KLKSSTSEKKAANE 472
++ + S+ + NE
Sbjct: 1927 EVNALKSKLRRGNE 1940
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 80.9 bits (198), Expect = 1e-14
Identities = 87/421 (20%), Positives = 191/421 (45%), Gaps = 39/421 (9%)
Query: 239 RLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEI 298
+L+D++ ++ +N +L +ER LL++ D+ E++++ +L + + E+
Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 299 LNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLE-QLG---EENQRLLKQTEM 354
K + + +LE +K+ + + E++A A ++ L+ QL EE Q L + +
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1108
Query: 355 LTQQRDTAI----QLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTT 410
Q++ A+ +L+ + ++ NKA Q +DL E+E L+ TEL T
Sbjct: 1109 EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK---TELEDT 1165
Query: 411 QVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAA 470
TA + E + V K + E +++ +++ + A +L + K A
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1225
Query: 471 NEEMEALRQIKDTVTMD-------AGRANKEVEILRKQCKALCQELKEALQEADVAKCRR 523
++ +Q + D G+A +EVE +K+ +A QEL+ + + A+
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA-- 1283
Query: 524 DWAFQERDKIVAERDSIRTLCDNLRRERDRAV----------SELAEALRSLDDTRKQKN 573
+ DK+ ++ + ++ L +A+ S+L + L + +QK
Sbjct: 1284 ----ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1339
Query: 574 DVSRELKELKEQ---MESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDI 630
+VS +L++L+E+ ++ QL++E +Q + H S ++ + + ++ +F E +
Sbjct: 1340 NVSTKLRQLEEERNSLQDQLDEEMEAKQNL--ERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 631 D 631
+
Sbjct: 1398 E 1398
Score = 76.3 bits (186), Expect = 3e-13
Identities = 83/399 (20%), Positives = 177/399 (44%), Gaps = 75/399 (18%)
Query: 237 QTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSS 296
Q + ++++ L +++ QL E+NLLQ+ + L+ E ++ L A++Q++
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL------E 928
Query: 297 EILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLT 356
EIL+++ + +++ E + A RK+ + Q++L E L
Sbjct: 929 EILHEM-EARLEEEEDRGQQLQAERKKMA--------------------QQMLDLEEQLE 967
Query: 357 QQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAK 416
++ +LQ + + + + + E+ QN L E +LL+ +++L T
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN------ 1021
Query: 417 ESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEA 476
++E ++ L KL+ + E S+L+ +++ + +E+E
Sbjct: 1022 -------------------LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE- 1061
Query: 477 LRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAE 536
++K + DA ++++ L+ Q L +L + +E A R D D+I +
Sbjct: 1062 --KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD------DEIAQK 1113
Query: 537 RDSIRTLCDNLRRERDRAVSELAEALRS----LDDTRKQKNDVSRELKELKEQMESQLEK 592
++++ + RE + +S+L E L S + KQK D+ EL+ LK ++E L+
Sbjct: 1114 NNALKKI-----RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1168
Query: 593 EARFRQLMAHSSHD-----SAIDTDSMEWETEVVEFERE 626
A ++L A + A+D ++ E +V E ++
Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Score = 75.9 bits (185), Expect = 4e-13
Identities = 108/521 (20%), Positives = 223/521 (42%), Gaps = 43/521 (8%)
Query: 137 LTDQ--QVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQ 194
LT+Q Q NL + + +E +L L + +L + L+ +
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Query: 195 CV---RAMSDLQSLQNQHTNALKRCEEVAKETDFYHT-LHSRLLSDQTRLKDDVDMLRRE 250
C RA ++L ++ N ++ + E + L + S ++L+D ++L+ E
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334
Query: 251 NGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGS-SEILNKLYDTA--M 307
Q L L+Q E+ L ++ +E+ + ++ + N S+ KL D A +
Sbjct: 1335 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 308 DKLEVVKKDY----DALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAI 363
+ LE KK + + L ++Y EK A + ++L + RL ++ + L D
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEKAAAY-------DKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 364 QLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYRE 423
QL R+F+ + E +++ D E + ++E E T + A+ E+ E
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYAD---ERDRAEAEAREKETKALSLARALEEALE 1504
Query: 424 ERDAVYSEYKLIMSERDQVISELDKLQTEV-ELAESK--LKSSTSEKKAANEEME-ALRQ 479
++ + K++ +E + ++S D + V EL +SK L++ E K EE+E L+
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 480 IKDT-----VTMDA--GRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDK 532
+D V M A G+ ++++ +Q + ++L+ L E + + ++R
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET---ELEDERKQRAL 1621
Query: 533 IVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEK 592
A + + +L + D A+ EA++ L + Q D REL+ +++ +
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE------DARASR 1675
Query: 593 EARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLK 633
+ F + +++ D M+ + ++ ER + DL+
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Score = 73.9 bits (180), Expect = 1e-12
Identities = 110/490 (22%), Positives = 215/490 (43%), Gaps = 67/490 (13%)
Query: 140 QQVNEKVENLSIQLRLMTRERNELRK---RLAFATHGTAFDKRPYHRLNPDYERLKIQCV 196
++ +++ENL+ Q ++L K RL D +L + E+ + +
Sbjct: 1402 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 197 RAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLR 256
+ +++ +++ +++ + R E A+E + +R L + K++ L R N L
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE---LERTNKMLKA 1518
Query: 257 ERNLLQQSWEDM-KRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKK 315
E L S +D+ K +HE ++ + RA + Q+ + E L D ++
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSK----RALETQMEEMKTQLEELEDELQATEDAKLRLEV 1574
Query: 316 DYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLK------QTEMLTQQRDTAI------ 363
+ AL+ ++ DL ++ EE +R L+ +TE+ +++ A+
Sbjct: 1575 NMQALKGQFER-------DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1627
Query: 364 -------QLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAK 416
L+ Q +++ E +L K AQ KD Q E+E ++ E+ TAK
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI----FATAK 1683
Query: 417 ESEKYRE--ERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEM 474
E+EK + E D + + L +ER + ++L+K ELAE +L SS S + A +E
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEK----EELAE-ELASSLSGRNALQDE- 1737
Query: 475 EALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIV 534
K + + +E+E + +A+ +++A Q+A+ Q +++
Sbjct: 1738 ------KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE----------QLSNELA 1781
Query: 535 AERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELK-EQMESQLEKE 593
ER + + ++ R++ +R EL L ++ K K + E K Q+E Q+E+E
Sbjct: 1782 TERSTAQK-NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 594 ARFRQLMAHS 603
AR +Q S
Sbjct: 1841 AREKQAATKS 1850
Score = 70.5 bits (171), Expect = 2e-11
Identities = 151/715 (21%), Positives = 289/715 (40%), Gaps = 143/715 (20%)
Query: 4 QRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLD----------EEAGGAKA 53
+ R LA +Q L + + E+EA L E G ER+++ EE A+
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 974
Query: 54 ELLLKLLLAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLST-MP 112
+L L+ + A+ A ++K + +L + N + + S L+T +
Sbjct: 975 KLQLEKVTAE---------AKIKKLEDEILVMDDQNNKLSKERKL--LEERISDLTTNLA 1023
Query: 113 SDSESSSSLSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATH 172
+ E + +L+ + + + L ++L+ + R EL K L
Sbjct: 1024 EEEEKAKNLTKL--------------KNKHESMISELEVRLKKEEKSRQELEK-LKRKLE 1068
Query: 173 GTAFDKRPYHR----LNPDYERLKIQCVRAMSDLQSLQ-------NQHTNALKRCEEVAK 221
G A D +H L LK+Q + +LQ+ Q NALK+ E+
Sbjct: 1069 GDASD---FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 222 ETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEE------D 275
+SD L++D+D R + +++ L + E +K E+
Sbjct: 1126 H-----------ISD---LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1171
Query: 276 QKEIGDLRAQQQQVLK---------HNGSSEILNKLYDTAMDKLEVVKKDYDALR---KR 323
Q+E+ R Q+ VLK H + + + + A+++L + + + +
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 324 YSEKVAIHNADLS-RLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHE 382
+ + NADL+ L LG+ Q + + + L Q +LQ +C+ R ++ +
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ---VQELQSKCSDGERARAELNDK 1288
Query: 383 LNKATAQNKDLQWEMELLQSELTELRTTQVKTAKE----SEKYREERDAVYSE--YKLIM 436
++K LQ E+E + L E +K AK+ S + ++ ++ + E KL +
Sbjct: 1289 VHK-------LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 437 SERDQVISE-----LDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTV-TMDAGR 490
S + + + E D+L E+E ++ + ++ ++ + L+ TV ++ G+
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1401
Query: 491 ANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRR- 549
+K+ + L Q+ +E D + ++ QE D +V + D+ R L NL +
Sbjct: 1402 KR-----FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 550 --------------------ERDRAVSELAE-------ALRSLDDTRKQKNDVSRELKEL 582
ERDRA +E E R+L++ + K ++ R K L
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 583 KEQMESQL-EKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERE---TEDIDLK 633
K +ME + K+ + + A++T E +T++ E E E TED L+
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Score = 59.3 bits (142), Expect = 3e-08
Identities = 93/485 (19%), Positives = 190/485 (39%), Gaps = 53/485 (10%)
Query: 116 ESSSSLSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTA 175
E+ L KA + + V + V L R + + E++ +L
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-------- 1555
Query: 176 FDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLS 235
L + + + +R ++Q+L+ Q L+ +E +E L +L
Sbjct: 1556 ------EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR--RQLQRQLHE 1607
Query: 236 DQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMK-------RLHEEDQKEIGDLRAQQQQ 288
+T L+D+ R++ + L+ +D++ + EE K++ L+AQ +
Sbjct: 1608 YETELEDE----RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK- 1662
Query: 289 VLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRL 348
+ +L D + E+ A K +K ADL +L++ +R
Sbjct: 1663 --------DFQRELEDARASRDEIF-----ATAKENEKKAKSLEADLMQLQEDLAAAERA 1709
Query: 349 LKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELR 408
KQ ++ ++ L + A SL A+ E + A+ L+ E+E Q + +
Sbjct: 1710 RKQADLEKEE------LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 409 TTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKK 468
K +++E+ E S + S R Q+ + +L++++ E +KS
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 469 AANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQ 528
AA E A Q+++ V +A +E + K K ++LKE L + + + + +
Sbjct: 1824 AALEAKIA--QLEEQVEQEA----REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1877
Query: 529 ERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMES 588
+ +K A ++ + E R + + R LD+ + + RE+ LK ++
Sbjct: 1878 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1937
Query: 589 QLEKE 593
+E
Sbjct: 1938 PPPQE 1942
Score = 58.9 bits (141), Expect = 5e-08
Identities = 107/508 (21%), Positives = 199/508 (39%), Gaps = 56/508 (11%)
Query: 140 QQVNEKVENLSIQLRLMTRERNELRKR---LAFATHGTAFDKRPYHRLNPDYERLKIQCV 196
Q+ + VE L+ QL R + L K L A + R + + E K +
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 197 RAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQ--- 253
+ +LQS + A A+ D H L Q ++ ML G+
Sbjct: 1266 AQVQELQSKCSDGERAR------AELNDKVHKL-------QNEVESVTGMLNEAEGKAIK 1312
Query: 254 LLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVV 313
L ++ L +D + L +E+ ++ ++ + +Q+ + S L D M+ + +
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS---LQDQLDEEMEAKQNL 1369
Query: 314 KKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSL 373
++ L + S+ S +E L E +R K+ E LTQQ + + +
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 374 RRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYK 433
R + +L + L +E Q + +L + S KY +ERD +E +
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI---SSKYADERDRAEAEAR 1486
Query: 434 LIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANK 493
E++ L + E A+ +L+ + KA EME L KD D G+
Sbjct: 1487 ----EKETKALSLARALEEALEAKEELERTNKMLKA---EMEDLVSSKD----DVGKNVH 1535
Query: 494 EVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDR 553
E+E ++ + +E+K L+E + D++ A D+ L N++ +
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELE-------------DELQATEDAKLRLEVNMQALK-- 1580
Query: 554 AVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDS 613
+ L++ D+ ++K R+L+ + E++LE E + R L A + D
Sbjct: 1581 --GQFERDLQARDEQNEEKR---RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 614 MEWETEVVEFERETEDIDLKALGFDMAE 641
+E + + RE L+ L M +
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKD 1663
Score = 49.3 bits (116), Expect = 4e-05
Identities = 65/330 (19%), Positives = 128/330 (38%), Gaps = 46/330 (13%)
Query: 311 EVVKKDYDALRKRYSEKVAIHNADLSRLEQ----LGEENQRLLKQTEMLTQQRDTAIQLQ 366
E ++ D L+K + N +L LEQ L EE L +Q + T+ A +++
Sbjct: 859 EEMQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 367 HQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERD 426
+ A + E I HE+ + +D +++ + ++ + + +E E R+
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ--- 974
Query: 427 AVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSE---KKAANEEMEALRQIKDT 483
KLQ E AE+K+K E N ++ R++ +
Sbjct: 975 ---------------------KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 484 VTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERD----- 538
D E E K L + + + E +V + + + QE +K+ + +
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 539 ------SIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELK---EQMESQ 589
++ L+ + + EL AL LDD QKN+ ++++EL+ ++
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 590 LEKEARFRQLMAHSSHDSAIDTDSMEWETE 619
L+ E R D + ++++ E E
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELE 1163
Score = 43.5 bits (101), Expect = 0.002
Identities = 61/299 (20%), Positives = 136/299 (45%), Gaps = 46/299 (15%)
Query: 357 QQRDTAIQ-LQHQCALSLR-------RFEAIHHELNKATAQNKDLQWEMELLQSELTELR 408
QQ+ TA++ +Q CA L+ R L + T Q + EM+ + EL + +
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEE----EMQAKEDELQKTK 872
Query: 409 TTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVEL-AESK-LKSSTSE 466
Q K E ++ ++ + E L+ ++LQ E EL AE++ ++ +
Sbjct: 873 ERQQKAENELKELEQKHSQLTEEKNLLQ----------EQLQAETELYAEAEEMRVRLAA 922
Query: 467 KKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWA 526
KK EE+ L +++ + + R ++++ RK+ +L+E L+E + A+ +
Sbjct: 923 KKQELEEI--LHEMEARLEEEEDR-GQQLQAERKKMAQQMLDLEEQLEEEEAARQK---- 975
Query: 527 FQERDKIVAE------RDSIRTLCD---NLRRER---DRAVSELAEALRSLDDTRKQKND 574
+ +K+ AE D I + D L +ER + +S+L L ++ K
Sbjct: 976 -LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034
Query: 575 VSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLK 633
+ + + + ++E +L+KE + RQ + ++ D+ ++ ++ + + + ++ ++
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKR--KLEGDASDFHEQIADLQAQIAELKMQ 1091
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 80.9 bits (198), Expect = 1e-14
Identities = 87/421 (20%), Positives = 191/421 (45%), Gaps = 39/421 (9%)
Query: 239 RLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEI 298
+L+D++ ++ +N +L +ER LL++ D+ E++++ +L + + E+
Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 299 LNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLE-QLG---EENQRLLKQTEM 354
K + + +LE +K+ + + E++A A ++ L+ QL EE Q L + +
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1101
Query: 355 LTQQRDTAI----QLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTT 410
Q++ A+ +L+ + ++ NKA Q +DL E+E L+ TEL T
Sbjct: 1102 EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK---TELEDT 1158
Query: 411 QVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAA 470
TA + E + V K + E +++ +++ + A +L + K A
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1218
Query: 471 NEEMEALRQIKDTVTMD-------AGRANKEVEILRKQCKALCQELKEALQEADVAKCRR 523
++ +Q + D G+A +EVE +K+ +A QEL+ + + A+
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA-- 1276
Query: 524 DWAFQERDKIVAERDSIRTLCDNLRRERDRAV----------SELAEALRSLDDTRKQKN 573
+ DK+ ++ + ++ L +A+ S+L + L + +QK
Sbjct: 1277 ----ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1332
Query: 574 DVSRELKELKEQ---MESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDI 630
+VS +L++L+E+ ++ QL++E +Q + H S ++ + + ++ +F E +
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDEEMEAKQNL--ERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 631 D 631
+
Sbjct: 1391 E 1391
Score = 76.3 bits (186), Expect = 3e-13
Identities = 83/399 (20%), Positives = 177/399 (44%), Gaps = 75/399 (18%)
Query: 237 QTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSS 296
Q + ++++ L +++ QL E+NLLQ+ + L+ E ++ L A++Q++
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL------E 921
Query: 297 EILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLT 356
EIL+++ + +++ E + A RK+ + Q++L E L
Sbjct: 922 EILHEM-EARLEEEEDRGQQLQAERKKMA--------------------QQMLDLEEQLE 960
Query: 357 QQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAK 416
++ +LQ + + + + + E+ QN L E +LL+ +++L T
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN------ 1014
Query: 417 ESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEA 476
++E ++ L KL+ + E S+L+ +++ + +E+E
Sbjct: 1015 -------------------LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE- 1054
Query: 477 LRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAE 536
++K + DA ++++ L+ Q L +L + +E A R D D+I +
Sbjct: 1055 --KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD------DEIAQK 1106
Query: 537 RDSIRTLCDNLRRERDRAVSELAEALRS----LDDTRKQKNDVSRELKELKEQMESQLEK 592
++++ + RE + +S+L E L S + KQK D+ EL+ LK ++E L+
Sbjct: 1107 NNALKKI-----RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1161
Query: 593 EARFRQLMAHSSHD-----SAIDTDSMEWETEVVEFERE 626
A ++L A + A+D ++ E +V E ++
Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Score = 75.9 bits (185), Expect = 4e-13
Identities = 108/521 (20%), Positives = 223/521 (42%), Gaps = 43/521 (8%)
Query: 137 LTDQ--QVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQ 194
LT+Q Q NL + + +E +L L + +L + L+ +
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 195 CV---RAMSDLQSLQNQHTNALKRCEEVAKETDFYHT-LHSRLLSDQTRLKDDVDMLRRE 250
C RA ++L ++ N ++ + E + L + S ++L+D ++L+ E
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327
Query: 251 NGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGS-SEILNKLYDTA--M 307
Q L L+Q E+ L ++ +E+ + ++ + N S+ KL D A +
Sbjct: 1328 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 308 DKLEVVKKDY----DALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAI 363
+ LE KK + + L ++Y EK A + ++L + RL ++ + L D
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEKAAAY-------DKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 364 QLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYRE 423
QL R+F+ + E +++ D E + ++E E T + A+ E+ E
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYAD---ERDRAEAEAREKETKALSLARALEEALE 1497
Query: 424 ERDAVYSEYKLIMSERDQVISELDKLQTEV-ELAESK--LKSSTSEKKAANEEME-ALRQ 479
++ + K++ +E + ++S D + V EL +SK L++ E K EE+E L+
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 480 IKDT-----VTMDA--GRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDK 532
+D V M A G+ ++++ +Q + ++L+ L E + + ++R
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET---ELEDERKQRAL 1614
Query: 533 IVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEK 592
A + + +L + D A+ EA++ L + Q D REL+ +++ +
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE------DARASR 1668
Query: 593 EARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLK 633
+ F + +++ D M+ + ++ ER + DL+
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Score = 73.9 bits (180), Expect = 1e-12
Identities = 110/490 (22%), Positives = 215/490 (43%), Gaps = 67/490 (13%)
Query: 140 QQVNEKVENLSIQLRLMTRERNELRK---RLAFATHGTAFDKRPYHRLNPDYERLKIQCV 196
++ +++ENL+ Q ++L K RL D +L + E+ + +
Sbjct: 1395 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 197 RAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLR 256
+ +++ +++ +++ + R E A+E + +R L + K++ L R N L
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE---LERTNKMLKA 1511
Query: 257 ERNLLQQSWEDM-KRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKK 315
E L S +D+ K +HE ++ + RA + Q+ + E L D ++
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSK----RALETQMEEMKTQLEELEDELQATEDAKLRLEV 1567
Query: 316 DYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLK------QTEMLTQQRDTAI------ 363
+ AL+ ++ DL ++ EE +R L+ +TE+ +++ A+
Sbjct: 1568 NMQALKGQFER-------DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1620
Query: 364 -------QLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAK 416
L+ Q +++ E +L K AQ KD Q E+E ++ E+ TAK
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI----FATAK 1676
Query: 417 ESEKYRE--ERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEM 474
E+EK + E D + + L +ER + ++L+K ELAE +L SS S + A +E
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEK----EELAE-ELASSLSGRNALQDE- 1730
Query: 475 EALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIV 534
K + + +E+E + +A+ +++A Q+A+ Q +++
Sbjct: 1731 ------KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE----------QLSNELA 1774
Query: 535 AERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELK-EQMESQLEKE 593
ER + + ++ R++ +R EL L ++ K K + E K Q+E Q+E+E
Sbjct: 1775 TERSTAQK-NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 594 ARFRQLMAHS 603
AR +Q S
Sbjct: 1834 AREKQAATKS 1843
Score = 70.5 bits (171), Expect = 2e-11
Identities = 151/715 (21%), Positives = 289/715 (40%), Gaps = 143/715 (20%)
Query: 4 QRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLD----------EEAGGAKA 53
+ R LA +Q L + + E+EA L E G ER+++ EE A+
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 967
Query: 54 ELLLKLLLAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLST-MP 112
+L L+ + A+ A ++K + +L + N + + S L+T +
Sbjct: 968 KLQLEKVTAE---------AKIKKLEDEILVMDDQNNKLSKERKL--LEERISDLTTNLA 1016
Query: 113 SDSESSSSLSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATH 172
+ E + +L+ + + + L ++L+ + R EL K L
Sbjct: 1017 EEEEKAKNLTKL--------------KNKHESMISELEVRLKKEEKSRQELEK-LKRKLE 1061
Query: 173 GTAFDKRPYHR----LNPDYERLKIQCVRAMSDLQSLQ-------NQHTNALKRCEEVAK 221
G A D +H L LK+Q + +LQ+ Q NALK+ E+
Sbjct: 1062 GDASD---FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 222 ETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEE------D 275
+SD L++D+D R + +++ L + E +K E+
Sbjct: 1119 H-----------ISD---LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1164
Query: 276 QKEIGDLRAQQQQVLK---------HNGSSEILNKLYDTAMDKLEVVKKDYDALR---KR 323
Q+E+ R Q+ VLK H + + + + A+++L + + + +
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 324 YSEKVAIHNADLS-RLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHE 382
+ + NADL+ L LG+ Q + + + L Q +LQ +C+ R ++ +
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ---VQELQSKCSDGERARAELNDK 1281
Query: 383 LNKATAQNKDLQWEMELLQSELTELRTTQVKTAKE----SEKYREERDAVYSE--YKLIM 436
++K LQ E+E + L E +K AK+ S + ++ ++ + E KL +
Sbjct: 1282 VHK-------LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 437 SERDQVISE-----LDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTV-TMDAGR 490
S + + + E D+L E+E ++ + ++ ++ + L+ TV ++ G+
Sbjct: 1335 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1394
Query: 491 ANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRR- 549
+K+ + L Q+ +E D + ++ QE D +V + D+ R L NL +
Sbjct: 1395 KR-----FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 550 --------------------ERDRAVSELAE-------ALRSLDDTRKQKNDVSRELKEL 582
ERDRA +E E R+L++ + K ++ R K L
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 583 KEQMESQL-EKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERE---TEDIDLK 633
K +ME + K+ + + A++T E +T++ E E E TED L+
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Score = 59.3 bits (142), Expect = 3e-08
Identities = 93/485 (19%), Positives = 190/485 (39%), Gaps = 53/485 (10%)
Query: 116 ESSSSLSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTA 175
E+ L KA + + V + V L R + + E++ +L
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-------- 1548
Query: 176 FDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLS 235
L + + + +R ++Q+L+ Q L+ +E +E L +L
Sbjct: 1549 ------EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR--RQLQRQLHE 1600
Query: 236 DQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMK-------RLHEEDQKEIGDLRAQQQQ 288
+T L+D+ R++ + L+ +D++ + EE K++ L+AQ +
Sbjct: 1601 YETELEDE----RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK- 1655
Query: 289 VLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRL 348
+ +L D + E+ A K +K ADL +L++ +R
Sbjct: 1656 --------DFQRELEDARASRDEIF-----ATAKENEKKAKSLEADLMQLQEDLAAAERA 1702
Query: 349 LKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELR 408
KQ ++ ++ L + A SL A+ E + A+ L+ E+E Q + +
Sbjct: 1703 RKQADLEKEE------LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 409 TTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKK 468
K +++E+ E S + S R Q+ + +L++++ E +KS
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 469 AANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQ 528
AA E A Q+++ V +A +E + K K ++LKE L + + + + +
Sbjct: 1817 AALEAKIA--QLEEQVEQEA----REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1870
Query: 529 ERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMES 588
+ +K A ++ + E R + + R LD+ + + RE+ LK ++
Sbjct: 1871 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1930
Query: 589 QLEKE 593
+E
Sbjct: 1931 PPPQE 1935
Score = 58.9 bits (141), Expect = 5e-08
Identities = 107/508 (21%), Positives = 199/508 (39%), Gaps = 56/508 (11%)
Query: 140 QQVNEKVENLSIQLRLMTRERNELRKR---LAFATHGTAFDKRPYHRLNPDYERLKIQCV 196
Q+ + VE L+ QL R + L K L A + R + + E K +
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 197 RAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQ--- 253
+ +LQS + A A+ D H L Q ++ ML G+
Sbjct: 1259 AQVQELQSKCSDGERAR------AELNDKVHKL-------QNEVESVTGMLNEAEGKAIK 1305
Query: 254 LLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVV 313
L ++ L +D + L +E+ ++ ++ + +Q+ + S L D M+ + +
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS---LQDQLDEEMEAKQNL 1362
Query: 314 KKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSL 373
++ L + S+ S +E L E +R K+ E LTQQ + + +
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 374 RRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYK 433
R + +L + L +E Q + +L + S KY +ERD +E +
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI---SSKYADERDRAEAEAR 1479
Query: 434 LIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANK 493
E++ L + E A+ +L+ + KA EME L KD D G+
Sbjct: 1480 ----EKETKALSLARALEEALEAKEELERTNKMLKA---EMEDLVSSKD----DVGKNVH 1528
Query: 494 EVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDR 553
E+E ++ + +E+K L+E + D++ A D+ L N++ +
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELE-------------DELQATEDAKLRLEVNMQALK-- 1573
Query: 554 AVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDS 613
+ L++ D+ ++K R+L+ + E++LE E + R L A + D
Sbjct: 1574 --GQFERDLQARDEQNEEKR---RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 614 MEWETEVVEFERETEDIDLKALGFDMAE 641
+E + + RE L+ L M +
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKD 1656
Score = 49.3 bits (116), Expect = 4e-05
Identities = 65/330 (19%), Positives = 128/330 (38%), Gaps = 46/330 (13%)
Query: 311 EVVKKDYDALRKRYSEKVAIHNADLSRLEQ----LGEENQRLLKQTEMLTQQRDTAIQLQ 366
E ++ D L+K + N +L LEQ L EE L +Q + T+ A +++
Sbjct: 852 EEMQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 367 HQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERD 426
+ A + E I HE+ + +D +++ + ++ + + +E E R+
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ--- 967
Query: 427 AVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSE---KKAANEEMEALRQIKDT 483
KLQ E AE+K+K E N ++ R++ +
Sbjct: 968 ---------------------KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 484 VTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERD----- 538
D E E K L + + + E +V + + + QE +K+ + +
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Query: 539 ------SIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELK---EQMESQ 589
++ L+ + + EL AL LDD QKN+ ++++EL+ ++
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 590 LEKEARFRQLMAHSSHDSAIDTDSMEWETE 619
L+ E R D + ++++ E E
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELE 1156
Score = 43.5 bits (101), Expect = 0.002
Identities = 61/299 (20%), Positives = 136/299 (45%), Gaps = 46/299 (15%)
Query: 357 QQRDTAIQ-LQHQCALSLR-------RFEAIHHELNKATAQNKDLQWEMELLQSELTELR 408
QQ+ TA++ +Q CA L+ R L + T Q + EM+ + EL + +
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEE----EMQAKEDELQKTK 865
Query: 409 TTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVEL-AESK-LKSSTSE 466
Q K E ++ ++ + E L+ ++LQ E EL AE++ ++ +
Sbjct: 866 ERQQKAENELKELEQKHSQLTEEKNLLQ----------EQLQAETELYAEAEEMRVRLAA 915
Query: 467 KKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWA 526
KK EE+ L +++ + + R ++++ RK+ +L+E L+E + A+ +
Sbjct: 916 KKQELEEI--LHEMEARLEEEEDR-GQQLQAERKKMAQQMLDLEEQLEEEEAARQK---- 968
Query: 527 FQERDKIVAE------RDSIRTLCD---NLRRER---DRAVSELAEALRSLDDTRKQKND 574
+ +K+ AE D I + D L +ER + +S+L L ++ K
Sbjct: 969 -LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027
Query: 575 VSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLK 633
+ + + + ++E +L+KE + RQ + ++ D+ ++ ++ + + + ++ ++
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKR--KLEGDASDFHEQIADLQAQIAELKMQ 1084
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 80.5 bits (197), Expect = 1e-14
Identities = 84/479 (17%), Positives = 218/479 (45%), Gaps = 44/479 (9%)
Query: 137 LTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKR--PYHRLNPDYERL--K 192
+TD+++ EK L +L+L+ E++E++ + K P +L + + L +
Sbjct: 275 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 334
Query: 193 IQCVRAMSDLQSLQNQHTNALKRCEE--VAKETDFYHTLHSRLLSDQTRLKDDVDMLRRE 250
+Q V A Q +N+ N L + +E + ++ + ++ + ++++ + +R +
Sbjct: 335 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 394
Query: 251 NGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKL 310
++ R+ ++ + E M+R E ++ +R Q++ + + L +K+
Sbjct: 395 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE-------EKM 447
Query: 311 EVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCA 370
+K + KR E+ + E+ E+ ++ +Q E + +Q + +++ Q
Sbjct: 448 HEQEKIREQEEKRQEEE------KIREQEKRQEQEAKMWRQEEKIREQEE---KIREQEE 498
Query: 371 LSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYS 430
R+ E IH + + + Q EM + ++ E Q + ++ EK E+ + +
Sbjct: 499 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE----QEEIWRQKEKIHEQEEKIRK 554
Query: 431 EYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGR 490
+ + + + +++ + +K++ + E K E+K +E E +R+ ++ +
Sbjct: 555 QEEKMWRQEEKMHDQEEKIREQEE------KVWRQEEKIREQE-EKIREQEEKIREQEEM 607
Query: 491 ANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRE 550
++ E + +Q + +C++ +E +QE + R++ +E++K + E++ + + +E
Sbjct: 608 TQEQEEKMGEQEEKMCEQ-EEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 666
Query: 551 RDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQ----LMAHSSH 605
++ + E E + +Q+ + + ++++ Q E E+E R RQ + H H
Sbjct: 667 QEEKMWEQEEKM------CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEH 719
Score = 49.7 bits (117), Expect = 3e-05
Identities = 55/292 (18%), Positives = 126/292 (43%), Gaps = 42/292 (14%)
Query: 338 LEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEM 397
L + + ++ + E LT++RD +L L R EL + +N LQ ++
Sbjct: 242 LSAVATQKKKADRYIEELTKERDAL-------SLELYRNTITDEELKE---KNAKLQEKL 291
Query: 398 ELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAE 457
+L++SE +E++ + ++ E+ + ++ + Q+ +E D L E++
Sbjct: 292 QLVESEKSEIQLNVKELKRKLERAK------------LLLPQQQLQAEADHLGKELQSVS 339
Query: 458 SKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEAD 517
+KL++ E + N R N++ E + + QE +E +QE +
Sbjct: 340 AKLQAQVEENELWN------------------RLNQQQEEKMWRQEEKIQEWEEKIQEQE 381
Query: 518 VAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSR 577
++ +E+++ + ++ + + R ++ + E E +R ++ +K + R
Sbjct: 382 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 441
Query: 578 ELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETED 629
EL+E + E E+E + ++ + + ++ W E E RE E+
Sbjct: 442 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE--EKIREQEE 491
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 80.1 bits (196), Expect = 2e-14
Identities = 120/582 (20%), Positives = 238/582 (40%), Gaps = 85/582 (14%)
Query: 128 GKAPSPPPLLTD--------QQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKR 179
G P+ LL D ++V E + + QLRL RE L+ L A +
Sbjct: 457 GPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALK---EEVASRDQ 513
Query: 180 PYHRLNPDYERLKIQCVRAMSD------LQSLQNQHTNALKR-----CEEVAKETDFYHT 228
+ Y+R Q R+M D + + Q +AL R EE ++ET + +
Sbjct: 514 EVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQS 573
Query: 229 LHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQ 288
+ + D K ++ LR E ++ E L + E ++R E+ + GD R Q +
Sbjct: 574 MFQKNKEDLRATKQELLQLRMEKEEMEEE---LGEKIEVLQRELEQARASAGDTR--QVE 628
Query: 289 VLKHN--GSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQ 346
VLK + E L +L + EV + D + +++A+ + R +L E+N
Sbjct: 629 VLKKELLRTQEELKELQAERQSQ-EVAGRHRD---RELEKQLAVLRVEADRGRELEEQNL 684
Query: 347 RLLKQTEMLTQQRDTAIQL----QHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQS 402
+L K + L Q + A + + + + +R A+ L + +N + + + L+
Sbjct: 685 QLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQ 744
Query: 403 ELTELR-------TTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVEL 455
+L E R + + + ++ E+ + E + + L+ +E
Sbjct: 745 QLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEE 804
Query: 456 AESKLKSSTSEKKAANEEMEA--------------LRQIKDTVTMDAGRANKEVEILRKQ 501
A+ L E++ N +E L + K + R NKE+E + +
Sbjct: 805 AQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGED 864
Query: 502 CKALCQELKEALQE---------ADVAKCRRDWAFQER------DKIVAERDSIRTLCDN 546
K Q+L+ L++ AD + +DWA + ++ E +R
Sbjct: 865 SKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQA 924
Query: 547 LRRERDRAVSE---LAEALRSL----DDTRKQKNDVSRELKELKE---QMESQLEKEARF 596
+ ERD A + LA+ L+ L ++ ++ ++D +R+LK L+E ++E++L++E
Sbjct: 925 SQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNT 984
Query: 597 RQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFD 638
+L+ + D + TE+++ +D++ + +
Sbjct: 985 VELLTDRVNRGRDQVDQL--RTELMQERSARQDLECDKISLE 1024
Score = 61.6 bits (148), Expect = 7e-09
Identities = 90/433 (20%), Positives = 184/433 (42%), Gaps = 67/433 (15%)
Query: 232 RLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWED----MKRLHEEDQ--KEIGDLRAQ 285
RL +++ +L++ ++ + E G L + L+ E+ + RL +E Q + +
Sbjct: 769 RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGK 828
Query: 286 QQQVLKHNGSS-----EILNKLYDTAMDKLEVVKKD-------YDALRKRYSEKVAIHNA 333
Q++VL+ + +L++ D +LE + +D A + Y EK A
Sbjct: 829 QREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVA 888
Query: 334 DLSR---------------LEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEA 378
D R L +L +E QRL + + +RDTA +L + L +R +
Sbjct: 889 DAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTA-RLDKE--LLAQRLQG 945
Query: 379 IHHEL-NKATAQN------KDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSE 431
+ E NK +Q+ K L+ ++ L++EL E + T + R++ D + +E
Sbjct: 946 LEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTE 1005
Query: 432 YKLIMSERDQVISELDKLQTEVELAESKLKSSTSE----KKAANEEMEALRQIKDTVTMD 487
S R + E DK+ E + + K + ++SE A+ ++E+ Q+
Sbjct: 1006 LMQERSARQDL--ECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQA 1063
Query: 488 AGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNL 547
R ++ ++ + +EL +++ ER + ++D + L
Sbjct: 1064 EEREKTVLQSTNRKLERKVKELSIQIED-------------ERQHVNDQKDQLSLRVKAL 1110
Query: 548 RRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEK-EARFRQLMAHSSHD 606
+R+ V E E + LD RK+ E E+ EQ++++++ E + + S+ +
Sbjct: 1111 KRQ----VDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAE 1166
Query: 607 SAIDTDSMEWETE 619
SA+ + + + E
Sbjct: 1167 SALKNEGLSSDEE 1179
Score = 58.5 bits (140), Expect = 6e-08
Identities = 72/344 (20%), Positives = 152/344 (44%), Gaps = 13/344 (3%)
Query: 141 QVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRAMS 200
++ ++ + L+ L ++R LR+ A R RLN + E++ +A+
Sbjct: 811 RLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQ 870
Query: 201 DLQS-LQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERN 259
LQ+ L++ A + + ++ + + + +RL+D++ LR+ ER+
Sbjct: 871 QLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERD 930
Query: 260 LLQQSWEDM-KRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYD 318
+ E + +RL +Q+ R+Q + + G E +++L +T +D+ K +
Sbjct: 931 TARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRL-ETELDE---EKNTVE 986
Query: 319 ALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEA 378
L R + D R E + E + R + + ++ +R L+ + A S F+
Sbjct: 987 LLTDRVNR--GRDQVDQLRTELMQERSARQDLECDKISLERQNK-DLKTRLASS-EGFQK 1042
Query: 379 IHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSE 438
L++ +QN+ LQ E LQ+E E Q K K +E + E + + +
Sbjct: 1043 PSASLSQLESQNQLLQ---ERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQ 1099
Query: 439 RDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKD 482
+DQ+ + L+ +V+ AE +++ +K A E+E ++ +
Sbjct: 1100 KDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNE 1143
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 79.0 bits (193), Expect = 4e-14
Identities = 92/445 (20%), Positives = 188/445 (42%), Gaps = 68/445 (15%)
Query: 202 LQSLQNQHTNALKRCEEVAKETDFY-HTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNL 260
LQ N+ ++ + V+ E + + +L +L S Q ++ ++ LR +L + L
Sbjct: 1342 LQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAG-LEHLRELQPKLDELQKL 1400
Query: 261 LQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDAL 320
+ + ED+ L + ++ L Q ++++ + L+ +LE+ K++D
Sbjct: 1401 ISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHT-------QLEMQAKEHD-- 1451
Query: 321 RKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIH 380
R++QL E + ++ E + ++ Q+Q R+ +A
Sbjct: 1452 ---------------ERIKQLQVELCEMKQKPEEIGEESRAKQQIQ-------RKLQAAL 1489
Query: 381 HELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERD 440
+A +NK LQ E+ L + + L + + +E+D V L+ ERD
Sbjct: 1490 ISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERD 1549
Query: 441 QVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRK 500
++I+E+D+ S E ++ + E+L+ + +T D + KE+E L+
Sbjct: 1550 KLITEMDR--------------SLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKS 1595
Query: 501 QCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAE 560
A E +E +E + Q + + E + I+ + + +R+E+ +L
Sbjct: 1596 SKIAESTEWQEKHKELQK---EYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRS 1652
Query: 561 ALRSLDDTRKQKNDVSRELKELKEQMES----------QLEKEARFRQLMAHSSHDSAID 610
+ +T KQ + +E++E+KE+M +LE+E + H + D+A +
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712
Query: 611 --------TDSMEWETEVVEFERET 627
SM+ E E V+ E ET
Sbjct: 1713 CMETLLSSNASMKEELERVKMEYET 1737
Score = 75.1 bits (183), Expect = 6e-13
Identities = 120/547 (21%), Positives = 228/547 (41%), Gaps = 83/547 (15%)
Query: 108 LSTMPSDSESSSSLSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRL 167
+ST P+ SES S S P + D ++++ N Q+ ++L++R+
Sbjct: 1805 MSTRPTCSESVPSAKSAN--------PAVSKDFSSHDEINNYLQQI-------DQLKERI 1849
Query: 168 AFATHGTAFDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHT--NALKRC--EEVAKET 223
A +K L + L Q +L+ LQ + T N L + EE+++ T
Sbjct: 1850 AGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909
Query: 224 DFYHT-------LHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKR----LH 272
T L RL++ L + ++ + LL+ +++K+ L
Sbjct: 1910 KLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELE 1969
Query: 273 EEDQKEIGDLRAQQQQVLKHN-----------GSSEILNKLYDTAMDKLEVVKKDYDALR 321
EE Q+ + + + ++ K G+ +L + +K + VK+ L+
Sbjct: 1970 EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQ----LQ 2025
Query: 322 K---RYSEKVAIHNADLSRLEQLGEENQRLLKQT-EMLTQQRDTAIQLQHQCALSLRRFE 377
K RY EK++ + LE + E+Q+ L+ T E L Q + + Q + A +
Sbjct: 2026 KDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLD 2085
Query: 378 AIHHELNKATAQN----KDLQWEMELLQSELTE--------LRTTQVKTAKESEKYREER 425
E + A N K+LQ E ++S++ + L + K KE + +E+
Sbjct: 2086 DTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL 2145
Query: 426 DAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVT 485
DA+ E + ++ L+K EV+ + L S+ ++ A + M +L+ +D V
Sbjct: 2146 DALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVI 2205
Query: 486 MDAGR---------ANKEVEILRKQCKALCQELKEALQEADV--AKCRRDWAFQERDKIV 534
+A + +KE EI K+ C LK+ L++ + + + + + E DK +
Sbjct: 2206 DEAKKWERKFSDAIQSKEEEIRLKEDN--CSVLKDQLRQMSIHMEELKINISRLEHDKQI 2263
Query: 535 AERDS------IRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQ--- 585
E + + +CD L+ E +S+L E ++ + + ELK LK+Q
Sbjct: 2264 WESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTD 2323
Query: 586 MESQLEK 592
+ + LEK
Sbjct: 2324 LSNSLEK 2330
Score = 60.5 bits (145), Expect = 2e-08
Identities = 119/581 (20%), Positives = 236/581 (40%), Gaps = 69/581 (11%)
Query: 106 SVLSTMPSDSESSSSLSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRL--MTRERNEL 163
S L+ + + + ++ +S T + LL+ + V L Q++ M E
Sbjct: 719 SNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAER 778
Query: 164 RKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKET 223
++RL + + TA D + L L I+ ++ LQN+ + + E ++
Sbjct: 779 QRRLDYESQ-TAHD----NLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSE---QS 830
Query: 224 DFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLR 283
+L S+L + ++ + + + +R + ++ L Q ++ ++ + ++ D+
Sbjct: 831 TLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVE 890
Query: 284 AQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKV-AIHNADLSRLEQLG 342
QQ + + + ++ M +L K K E++ + A+ ++ EQ+
Sbjct: 891 TLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVE 950
Query: 343 EENQRL--LKQT--EMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEME 398
E+N+ LKQ EM + + +LQH+ L + E +L A K+L +
Sbjct: 951 EDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVS 1010
Query: 399 LLQSELTELRTTQVK--TAKESEKYREERDAVYSEY--KLIMSERDQVISELDKLQTEVE 454
L+ EL L+ K E+E+ E D EY K + S+ ++ L + +E E
Sbjct: 1011 RLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKE 1070
Query: 455 LAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQC---KALCQEL-- 509
+ ++ EK AA E+ +AL + + D ++++L+ + +A+ Q+L
Sbjct: 1071 VELQHIRKDLEEKLAAEEQFQALVKQMNQTLQD---KTNQIDLLQAEISENQAIIQKLIT 1127
Query: 510 --KEALQEADVAKCR-------------RDWAFQERDKIVAERDSIRTLCDNLRRERDRA 554
+A VA + W + +KI+A L +E+++
Sbjct: 1128 SNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILA-----------LEKEKEQL 1176
Query: 555 VSELAEALRSLDDTRKQKNDVSRELK-ELKEQMESQLEKEARFRQLMAHSSHDSAIDTDS 613
+L EAL S K+ + R L+ ELK+Q + + +F + S + I
Sbjct: 1177 QKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDE---QSKENENIGDQL 1233
Query: 614 MEWETEVVEFERETEDIDLKALGFDMAE------GVNEPCF 648
+ + +V E ID K D E G+ EP F
Sbjct: 1234 RQLQIQV------RESIDGKLPSTDQQESCSSTPGLEEPLF 1268
Score = 60.5 bits (145), Expect = 2e-08
Identities = 83/495 (16%), Positives = 199/495 (40%), Gaps = 79/495 (15%)
Query: 197 RAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLR 256
R + D Q L+ +H + + +++ +E +++L + L+ +D L EN +L
Sbjct: 2475 RIVGDYQQLEERHLSIILEKDQLIQEAA---AENNKLKEEIRGLRSHMDDLNSENAKLDA 2531
Query: 257 ERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHN------------GSSEILNKLYD 304
E ++ + + + QK++ +++ QQ + L++ ++E L + ++
Sbjct: 2532 ELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFN 2591
Query: 305 TAMDKLEVVKKDYDALRKRYSE-------------------KVAIHNADLSRLEQLGEEN 345
++ + + K+ ++L+ S+ ++ + ++ RL L +
Sbjct: 2592 ALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSS 2651
Query: 346 QRLLKQTE--MLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSE 403
Q+ + + E ++ Q++ A ++ + + +HH+ + + + + L +
Sbjct: 2652 QKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD 2711
Query: 404 LTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSS 463
L E+ + KE++ + + + + RD ELD+L+ + + A K +
Sbjct: 2712 LVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYD-ASLKELAQ 2770
Query: 464 TSEKKAANEEMEAL--------RQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQE 515
E+ N E +AL ++ + N+++ +Q L +L+++ +
Sbjct: 2771 LKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
Query: 516 AD-------VAKCRRDWAFQERDKI-----------------VAERDSIRTLCDNLRRER 551
+ RD + E +K AE S++ +L+ +R
Sbjct: 2831 VQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDR 2890
Query: 552 DRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDT 611
DR + E L++L Q N EL LK Q++ +K F Q+M +
Sbjct: 2891 DRLLKE----LKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAF-QIM-----QEELRQ 2940
Query: 612 DSMEWETEVVEFERE 626
+++ W+ E+ + E
Sbjct: 2941 ENLSWQHELHQLRME 2955
Score = 58.5 bits (140), Expect = 6e-08
Identities = 107/542 (19%), Positives = 231/542 (42%), Gaps = 89/542 (16%)
Query: 139 DQQVNEKVENLSI---QLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQC 195
++++ K +N S+ QLR M+ EL+ ++ H DK+ + + ++Q
Sbjct: 2223 EEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEH----DKQIWE----SKAQTEVQL 2274
Query: 196 VRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLL 255
+ + D +LQ ++ L + EE YH+ + L ++ LK D QL
Sbjct: 2275 QQKVCD--TLQGENKELLSQLEETRH---LYHSSQNELAKLESELKSLKD-------QLT 2322
Query: 256 RERNLLQQSWEDMKRLHEEDQKEIGDLR----AQQQQVLKHNGSSEILNKLYDTAMDKLE 311
N L++ E L +++ D++ + +Q S E+ ++L++ E
Sbjct: 2323 DLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHE------E 2376
Query: 312 VVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTE-MLTQQRDTAIQLQHQCA 370
+ K+ + ++ AI A + +L +++ + +K+ E +L+Q+ + I L+
Sbjct: 2377 INMKEQKIISLLSGKEEAIQVA----IAELRQQHDKEIKELENLLSQEEEENIVLEE--- 2429
Query: 371 LSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYS 430
E KA + L ++ ++ E + + K + +RD +
Sbjct: 2430 -----------ENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
Query: 431 EYK-------LIMSERDQVISEL----DKLQTEVELAESKLKSSTSEKKAANEEMEALRQ 479
+Y+ I+ E+DQ+I E +KL+ E+ S + SE + E+ R+
Sbjct: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRE 2538
Query: 480 -IKDTVTMDAGRANKEVEILRKQCKAL---CQELKEALQEADVAK--CRRDW--AFQERD 531
+ +T+ + + +E+ +Q K L +L+E L+E++ A RR + +E+
Sbjct: 2539 DLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQ 2598
Query: 532 KIVAERDSIRTLCDNLRRE---------------RDRAVSELAEALRSL-DDTRKQKNDV 575
+ E +S++ L R+ + + E L +L ++K+ ++
Sbjct: 2599 DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAEL 2658
Query: 576 SRELKELKEQMESQL-EKEARFRQLMAHSSHDSAIDTDSMEW-ETEVVEFERETEDIDLK 633
EL ++++ ++ E E + ++ + H HD+ I + E E V E R+ +++ K
Sbjct: 2659 EEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQK 2718
Query: 634 AL 635
L
Sbjct: 2719 LL 2720
Score = 57.0 bits (136), Expect = 2e-07
Identities = 80/404 (19%), Positives = 157/404 (38%), Gaps = 81/404 (20%)
Query: 234 LSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHN 293
+ +++R K + R+ L+ + L+++ K L EE G + + +
Sbjct: 1471 IGEESRAKQQIQ--RKLQAALISRKEALKEN----KSLQEELSLARGTIERLTKSLADVE 1524
Query: 294 GSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSR--------LEQLGEEN 345
NK DT + +L +++++ D L + + N LS LE L E+
Sbjct: 1525 SQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSL-LENQSLSSSCESLKLALEGLTEDK 1583
Query: 346 QRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELT 405
++L+K+ E L + E + ++K+LQ E E+L
Sbjct: 1584 EKLVKEIESLKSSKIA--------------------ESTEWQEKHKELQKEYEILLQSYE 1623
Query: 406 ELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTS 465
+ + E R+E+ +Y + + +E +K +TE +L E
Sbjct: 1624 NVSNEAERIQHVVEAVRQEKQELYGKLR---------STEANKKETEKQLQE-------- 1666
Query: 466 EKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDW 525
A +EME ++ E +RK K+ Q++ E +E D +
Sbjct: 1667 ----AEQEMEEMK-----------------EKMRKFAKSKQQKILELEEENDRLRAE--- 1702
Query: 526 AFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQ 585
D +++ + +++ E +R E + +K+ +S E+++LK Q
Sbjct: 1703 VHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQ 1762
Query: 586 MESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETED 629
+E + K+A L A HD+ T+ E T+ + E E +D
Sbjct: 1763 IEGNVSKQA---NLEATEKHDN--QTNVTEEGTQSIPGETEEQD 1801
Score = 52.8 bits (125), Expect = 3e-06
Identities = 82/424 (19%), Positives = 171/424 (40%), Gaps = 58/424 (13%)
Query: 217 EEVAKETDFYHT---LHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHE 273
E + K T+ +HT L S L D +D L+ + L + E ++ L
Sbjct: 1265 EPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVE-LEL 1323
Query: 274 EDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNA 333
+ +L + ++V + E +NK ++ L+ V + + + +K+
Sbjct: 1324 KVSSTTSELTKKSEEVFQ---LQEQINK-QGLEIESLKTVSHEAEVHAESLQQKLESSQL 1379
Query: 334 DLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQ-----CALSLRRFEAIHHE-LNKAT 387
++ LE L E +L + ++++++ + L Q AL+ + E I E L KA
Sbjct: 1380 QIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKAL 1439
Query: 388 -----AQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQV 442
Q K+ ++ LQ EL E++ + +ES ++ + + + + R +
Sbjct: 1440 HTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQ----IQRKLQAALISRKEA 1495
Query: 443 ISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQC 502
+ E LQ E+ LA ++ T ++ A + KDTV GR
Sbjct: 1496 LKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVL---GRL----------- 1541
Query: 503 KALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEAL 562
AL QE RD E D+ + E S+ + C++L+ + + + +
Sbjct: 1542 -ALLQE-------------ERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLV 1587
Query: 563 RSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVE 622
+ ++ + K S E +E ++++ + E ++ S + + + + ++ E V
Sbjct: 1588 KEIESLKSSKIAESTEWQEKHKELQKEYE-------ILLQSYENVSNEAERIQHVVEAVR 1640
Query: 623 FERE 626
E++
Sbjct: 1641 QEKQ 1644
Score = 45.4 bits (106), Expect = 5e-04
Identities = 73/383 (19%), Positives = 165/383 (43%), Gaps = 44/383 (11%)
Query: 281 DLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQ 340
+L + Q+L+ + ++Y+ +D+ + + L + + +K A +N+ S
Sbjct: 685 ELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEF-KKNADNNS--SAFTA 741
Query: 341 LGEENQRLLKQTE---MLTQQRDTAIQLQHQCALSLRR----FEA-------IHHELNKA 386
L EE +LL Q + M+T+ R QL+ A + R+ +E+ + +++
Sbjct: 742 LSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSL 801
Query: 387 TAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQV---- 442
+ + K ++E+LQ+EL ++ Q++ +++S R + + ++ ++ ++V
Sbjct: 802 SIEAKSKDVKIEVLQNELDDV---QLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHIS 858
Query: 443 --ISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKD--------TVTMDAGRAN 492
+ EL + ++ EL +K+ EKK E ++ + KD ++T + N
Sbjct: 859 SKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLN 918
Query: 493 KEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERD 552
+E L + K L ++L L A+ AK ++++ + + L N
Sbjct: 919 EEKFSLGVEIKTLKEQL-NLLSRAEEAK---------KEQVEEDNEVSSGLKQNYDEMSP 968
Query: 553 RAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTD 612
E D +K+ R+L+ + L++ +R + +A+ +S +
Sbjct: 969 AGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIP 1028
Query: 613 SMEWETEVVEFERETEDIDLKAL 635
E E VE ++E ++ K +
Sbjct: 1029 LSETERGEVEEDKENKEYSEKCV 1051
Score = 44.7 bits (104), Expect = 9e-04
Identities = 70/317 (22%), Positives = 132/317 (41%), Gaps = 50/317 (15%)
Query: 335 LSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQ 394
L+ EQL E + +++Q ++ QQ+D A+Q + + A + + +H
Sbjct: 54 LAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLH-------------- 99
Query: 395 WEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVE 454
+++LT L KY EE A + ++ +S+ DK TE E
Sbjct: 100 -----AKAKLTSL-----------NKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEE 143
Query: 455 LAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVE--ILRKQCKALCQELKEA 512
+ K+K EK+ ++A Q+ +++ E+E ++ KQ +E
Sbjct: 144 MEIEKIKHKLQEKEELISTLQA--QLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFIST 201
Query: 513 LQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQK 572
LQ A+ + A Q ++V E+D+ +R D + + +A ++ +QK
Sbjct: 202 LQ----AQLSQTQAEQAAQQVVREKDA--RFETQVRLHEDELLQLVTQA--DVETEMQQK 253
Query: 573 NDV-SRELKELKEQMESQLEKEARFRQ-LMAHSSHDSAIDTDSMEWETE------VVEFE 624
V R+L+E +E + + + +Q L A + + + E E VE E
Sbjct: 254 LRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETE 313
Query: 625 RETEDIDLKALGFDMAE 641
RE I L+ + ++AE
Sbjct: 314 REESKILLEKMELEVAE 330
Score = 43.1 bits (100), Expect = 0.003
Identities = 79/400 (19%), Positives = 164/400 (41%), Gaps = 54/400 (13%)
Query: 217 EEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQ 276
+++ ++ +F TL ++L Q + Q++RE++ +E RLHE++
Sbjct: 190 QQLQEKEEFISTLQAQLSQTQAE---------QAAQQVVREKDA---RFETQVRLHEDEL 237
Query: 277 KEI---GDLRAQQQQVLK--------HNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYS 325
++ D+ + QQ L+ H S ++ D +L ++ L ++
Sbjct: 238 LQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQ 297
Query: 326 EKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAI-QLQHQCALSLRRFEAIHHELN 384
+ A HN + +E EE++ LL++ E+ +R + LQ + L +FE +
Sbjct: 298 QMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFE----QAG 353
Query: 385 KATAQNKDLQWEMELLQSELTELRTTQV-KTAKESEKYREERDAVYSE-YKLIMSERDQV 442
+A A+ + +E E +T+ + K ++ + DA+ + KL+ + +Q
Sbjct: 354 QAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQA 413
Query: 443 ISELDKL-QTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGR---ANKEVEIL 498
+ + Q E +L + + S + ++ E Q + G + + L
Sbjct: 414 VQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASL 473
Query: 499 RKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTL-----CDNLRRERDR 553
+K+ L E K AL + + E +++ AE + + + N E DR
Sbjct: 474 QKRVVELENE-KGALLLSSI----------ELEELKAENEKLSSQITLLEAQNRTGEADR 522
Query: 554 AVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKE 593
VSE++ +D K+ + +++ E SQ KE
Sbjct: 523 EVSEIS----IVDIANKRSSSAEESGQDVLENTFSQKHKE 558
Score = 33.9 bits (76), Expect = 1.6
Identities = 64/297 (21%), Positives = 126/297 (42%), Gaps = 40/297 (13%)
Query: 197 RAMSDLQSLQNQHTNALKRCEE----VAKETDFYHTLHSRLLSDQTRLKDDVDM---LRR 249
+AMS LQ+ +++ LK ++ + +E H L ++L Q + K M LR+
Sbjct: 2881 KAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQ 2940
Query: 250 ENGQLLRERNLLQQ---SWEDMKRLHEED--------QKEIGDLRAQQQQVLKHNGSSEI 298
EN E + L+ SWE +R +E +++ L+ +++ + ++
Sbjct: 2941 ENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQP 3000
Query: 299 LNKLYD--------TAMDKLEVVKKDYDALRKRYSEKVA-IHNADLSRLEQLGEENQRLL 349
L Y + D + + + + LR + ++ + IH +L R++QL +LL
Sbjct: 3001 LKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL-RIQQLNSNFSQLL 3059
Query: 350 KQTEMLTQQR-DTAIQLQ----------HQCALSLRRFEAIHH-ELNKATAQNKDLQWEM 397
++ L+ Q DT+ L+ + CA+ ++ + + LN A +
Sbjct: 3060 EEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNG 3119
Query: 398 ELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVE 454
+S+ ELR Q ++ ++ R V KL+ ERDQ ++ + L E
Sbjct: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEE 3176
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 78.6 bits (192), Expect = 6e-14
Identities = 134/645 (20%), Positives = 255/645 (39%), Gaps = 96/645 (14%)
Query: 9 LAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLDEEAGGAKAELLLKLLLAKERDHF 68
L+ + L Q +TE++ + LE D+E G AK E+ KL
Sbjct: 308 LSNKNEKLCQELTEIDQLAQQLERH---KEEVLETADKELGEAKKEIKRKL------SEM 358
Query: 69 QDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSSLSSVGTTG 128
QDL + K Q L LN + S L T+ E
Sbjct: 359 QDLEETMAKLQ------LELNLCQKEKERLSDELLVKSDLETVVHQLEQEK--------- 403
Query: 129 KAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDY 188
Q++++KVE+ ++ R +T E +R HG R RL+
Sbjct: 404 -----------QRLSKKVESFAVTERQLTLEVERMRLE-----HGIKRRDRSPSRLDT-- 445
Query: 189 ERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLR 248
+ ++ ++ + L+R + + + + +R S R + D
Sbjct: 446 ---------FLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDY-N 495
Query: 249 RENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMD 308
E Q+ RER+ LQ+ E ++ E+ Q + L A++ + L+ LY+ A +
Sbjct: 496 SEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDK----------LSVLYNEAQE 545
Query: 309 KLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQ 368
+L ALRK ++ A HN +S +E+ E+ L ++ ++ +L+H
Sbjct: 546 ELS-------ALRKESTQTTAPHNI-VSLMEK--EKELALSDLRRIMAEKEALREKLEHI 595
Query: 369 CALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAV 428
+SL + + T N L+ E L+S++ ++ T + + ++ V
Sbjct: 596 EEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHV 655
Query: 429 YSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDA 488
+ +E + + ++LQ V+ + +L E ++A +++ L + D + +
Sbjct: 656 AGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKM 715
Query: 489 GRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQE----RDKIVAERDSIRTLC 544
++E +++K + +E K+ LQE K + QE ++K VA+ + + C
Sbjct: 716 TSQDEEAHVMKKTIGVIDKE-KDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISEC 774
Query: 545 DN------------------LRRERDRAVSELAEALRSLDDTRKQKNDVSRELKEL-KEQ 585
++ LRR+ D A EL E RS + K+ + +L + +E
Sbjct: 775 ESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMAREN 834
Query: 586 MESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDI 630
E LE EA ++ S T+ WE+ + E+E +D+
Sbjct: 835 QEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDL 879
Score = 68.2 bits (165), Expect = 8e-11
Identities = 104/532 (19%), Positives = 221/532 (41%), Gaps = 70/532 (13%)
Query: 133 PPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLK 192
P P D + + ++ +++ + +E ++L+++LA G + + ERL
Sbjct: 186 PVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLS 245
Query: 193 IQCVRAMS-DLQSLQNQHTNALKRCEEVAKETDFYHTLHS-------RLLSDQTRLKDDV 244
+ S D+ SL++++ K + + DF + L+ + + +V
Sbjct: 246 VALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEV 305
Query: 245 DMLRRENGQLLRERNLLQQSWEDMKRLHEE----DQKEIGDLRAQQQQVLKHNGSSEILN 300
L +N +L +E + Q + ++R EE KE+G+ + + ++ L +
Sbjct: 306 VNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSE------MQ 359
Query: 301 KLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRD 360
L +T M KL++ ++R S+++ + + + + QL +E QRL K+ E
Sbjct: 360 DLEET-MAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVT-- 416
Query: 361 TAIQLQHQCALSLRRFEAIHHELNKATAQN------KDLQWEMELLQSELTELR------ 408
+ Q L + R H + + + K ++ E + + EL L+
Sbjct: 417 -----ERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRR 471
Query: 409 --TTQVKTAKESEKYREERDAVY-SEYKLIMSERDQVISELDKLQTEVELAESKLKSSTS 465
+T ++S +R Y SE I ERD++ L++ + +E +S +K T+
Sbjct: 472 SCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTA 531
Query: 466 EKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDW 525
E+ D +++ A +E+ LRK+ + + + ++
Sbjct: 532 ER--------------DKLSVLYNEAQEELSALRKEST----QTTAPHNIVSLMEKEKEL 573
Query: 526 AFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSREL------ 579
A + +I+AE++++R +++ SEL + + L Q EL
Sbjct: 574 ALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLI 633
Query: 580 -KELKEQMESQLEKEA-RFRQLMAHSSHDSAIDTDSMEWETEVVEFERETED 629
KE E +E++L+ +A +F + SSH + +S+ E + +R +D
Sbjct: 634 MKETIESLENKLKVQAQKFSHVAGDSSHQKT-EVNSLRIVNE--QLQRSVDD 682
Score = 60.8 bits (146), Expect = 1e-08
Identities = 116/603 (19%), Positives = 237/603 (39%), Gaps = 81/603 (13%)
Query: 61 LAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSS 120
+ +ERD Q + EK Y+ + + SVL +E+
Sbjct: 501 ITRERDELQRMLERFEK---------YMEDIQSNVKLLTAERDKLSVLY-----NEAQEE 546
Query: 121 LSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRP 180
LS++ + P + EK LS LR + E+ LR++L + F K
Sbjct: 547 LSALRKESTQTTAPHNIVSLMEKEKELALS-DLRRIMAEKEALREKLEHIEEVSLFGKSE 605
Query: 181 Y-----------HRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTL 229
H+L + LK + + ++SL+N+ ++ VA
Sbjct: 606 LEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVA--------- 656
Query: 230 HSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQV 289
D + K +V+ LR N QL R + Q + E Q +I L + ++
Sbjct: 657 -----GDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDEL 711
Query: 290 -LKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRY---SEKVAIHNADLSRLEQLGEEN 345
LK E + + T + V+ K+ D L++ +EK+A +L+ E+ +
Sbjct: 712 NLKMTSQDEEAHVMKKT----IGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQM 767
Query: 346 QRLLKQTEM-LTQQRDTAIQLQHQCALSLRRFEAIHHELNK-------ATAQNKDLQWEM 397
+ ++ + E + Q ++T + + R+ +A H EL++ A +N+ LQ ++
Sbjct: 768 KIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDL 827
Query: 398 ELLQSELTELRTTQVKTAKESEKYREERDAVYSE---YKLIMSERDQVISEL-DKLQTEV 453
+ E E+ +E E+ + +E ++ +M+ +++ +L D+ Q
Sbjct: 828 ATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLH 887
Query: 454 ELAES-KLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQ----- 507
AE ++K+ +E ++++ +E L ++ + + VE+L K+ +
Sbjct: 888 NRAEDWEVKAHQAEGESSSVRLELL-----SIDTERRHLRERVELLEKEIQEHINAHHAY 942
Query: 508 ELKEALQEADVAKCRRDWAFQERDKIVAERD--SIRTLCDNLRRERDRAVSELAEALRSL 565
E + + +++ + QE +K D S+R LC L +D +L
Sbjct: 943 ESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEF 1002
Query: 566 DDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFER 625
+ + +V E LK+Q+ ++ L+A + E+ + + E+
Sbjct: 1003 ERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNR--------DKEFHSHLTSHEK 1054
Query: 626 ETE 628
+TE
Sbjct: 1055 DTE 1057
Score = 54.3 bits (129), Expect = 1e-06
Identities = 87/436 (19%), Positives = 166/436 (38%), Gaps = 66/436 (15%)
Query: 108 LSTMPSDSESSSSLSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRL 167
L D E+ ++G K + V+EK E ++ L++ L
Sbjct: 713 LKMTSQDEEAHVMKKTIGVIDKEKD----FLQETVDEKTEKIA-----------NLQENL 757
Query: 168 AFATHGTAFDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYH 227
A A K +LK V ++ SL+ Q A K +EV + +
Sbjct: 758 ANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREI-- 815
Query: 228 TLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMK-RLHE------------- 273
+ RL+DD+ + REN ++ E Q E+MK R+H+
Sbjct: 816 -----AFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMA 870
Query: 274 EDQKEIGDL---------RAQQQQVLKHNG---SSEILNKLYDTAMDKLEVVKKDYDALR 321
+KE DL RA+ +V H SS + +L ++ +++ + L
Sbjct: 871 AKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRH-LRERVELLE 929
Query: 322 KRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAI----QLQHQCALSLRRFE 377
K E + H+A S++ + + RL ++ ++ T + L+ C +
Sbjct: 930 KEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKD 989
Query: 378 AIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMS 437
+ +LN + + + E+E ++SE L+ ++ ER V + L+ +
Sbjct: 990 IMTQQLNSKNLEFERVVVELENVKSESDLLK----------KQLSNERHTVKNLESLLAT 1039
Query: 438 ERDQVISE---LDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKE 494
RD+ + TE++L + KL S S+ + + E LR + D ++
Sbjct: 1040 NRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQ 1099
Query: 495 VEILRKQCKALCQELK 510
+ R + + QE++
Sbjct: 1100 ISTERYERERAIQEMR 1115
Score = 41.6 bits (96), Expect = 0.008
Identities = 65/339 (19%), Positives = 154/339 (45%), Gaps = 48/339 (14%)
Query: 147 ENLSIQLRLMTRERNELRKRL-AFATHGTAFDK--RPYHRLNPDY-ERLKIQCVRAMS-D 201
+ +S++L +E+ E++ R+ + T + ++ + N D +R ++ RA +
Sbjct: 835 QEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWE 894
Query: 202 LQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLL 261
+++ Q + ++ R E ++ +T+ H L R+ + +++ ++ Q+ +
Sbjct: 895 VKAHQAEGESSSVRLELLSIDTERRH-LRERVELLEKEIQEHINAHHAYESQISSMAKAM 953
Query: 262 QQSWEDMKRLHEEDQKE--IGDLRAQQQQVLKHNGSSEIL-------NKLYDTAMDKLEV 312
+ E+++ H+ED+K + DL + ++ +K + +I+ N ++ + +LE
Sbjct: 954 SRLEEELR--HQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELEN 1011
Query: 313 VKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALS 372
VK + D L+K+ S + + LE L N+ + + + ++DT IQL + L+
Sbjct: 1012 VKSESDLLKKQLSNE----RHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKE-KLT 1066
Query: 373 LRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEY 432
L +K T+Q++ E +L++++ +L+T + DA+ +
Sbjct: 1067 LSE--------SKLTSQSR----ENTMLRAKVAQLQT--------------DYDALKRQI 1100
Query: 433 KLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAAN 471
ER++ I E+ + S L+S + + N
Sbjct: 1101 STERYERERAIQEMRRHGLATPPLSSTLRSPSHSPEHRN 1139
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,887,022
Number of Sequences: 37866
Number of extensions: 4008981
Number of successful extensions: 26804
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 355
Number of HSP's successfully gapped in prelim test: 1274
Number of HSP's that attempted gapping in prelim test: 17171
Number of HSP's gapped (non-prelim): 7373
length of query: 1919
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1802
effective length of database: 13,817,196
effective search space: 24898587192
effective search space used: 24898587192
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.