Search of human proteins with 94536793

Search of human proteins with 94536793

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|94536793 tubulin tyrosine ligase-like family, member 7 [Homo
sapiens]
         (887 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|94536793 tubulin tyrosine ligase-like family, member 7 [Homo ...  1798   0.0  
gi|195963418 tubulin tyrosine ligase-like family, member 6 isofo...   372   e-103
gi|75677580 tubulin tyrosine ligase-like family, member 13 [Homo...   352   1e-96
gi|50658079 tubulin tyrosine ligase-like family, member 5 [Homo ...   216   1e-55
gi|212720861 tubulin tyrosine ligase-like family, member 11 a [H...   205   1e-52
gi|217330594 tubulin tyrosine ligase-like family, member 4 [Homo...   201   3e-51
gi|99028883 tubulin tyrosine ligase-like family, member 2 [Homo ...   186   6e-47
gi|89363028 tubulin tyrosine ligase-like family, member 11 b [Ho...   171   2e-42
gi|11068135 tubulin tyrosine ligase-like family, member 1 [Homo ...   142   2e-33
gi|195963416 tubulin tyrosine ligase-like family, member 6 isofo...   140   4e-33
gi|56606131 tubulin tyrosine ligase-like family, member 9 [Homo ...   127   3e-29
gi|109134340 tubulin tyrosine ligase-like family, member 3 [Homo...    91   6e-18
gi|24308516 tubulin tyrosine ligase [Homo sapiens]                     83   1e-15
gi|194239681 tubulin tyrosine ligase-like family, member 10 isof...    74   5e-13
gi|122937293 tubulin tyrosine ligase-like family, member 8 [Homo...    73   1e-12
gi|194239678 tubulin tyrosine ligase-like family, member 10 isof...    51   5e-06
gi|11056036 tubulin tyrosine ligase-like family, member 12 [Homo...    50   7e-06
gi|27734775 hypothetical protein LOC286499 [Homo sapiens]              44   7e-04
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...    43   0.001
gi|4758650 kinesin family member 5C [Homo sapiens]                     41   0.004
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    40   0.010
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]     40   0.013
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]     40   0.013
gi|38569484 kinesin family member 21A [Homo sapiens]                   40   0.013
gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]                       40   0.013
gi|4826657 caldesmon 1 isoform 2 [Homo sapiens]                        40   0.013
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       40   0.013
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    40   0.013
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...    40   0.013
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...    40   0.013

>gi|94536793 tubulin tyrosine ligase-like family, member 7 [Homo
           sapiens]
          Length = 887

 Score = 1798 bits (4657), Expect = 0.0
 Identities = 887/887 (100%), Positives = 887/887 (100%)

Query: 1   MPSLPQEGVIQGPSPLDLNTELPYQSTMKRKVRKKKKKGTITANVAGTKFEIVRLVIDEM 60
           MPSLPQEGVIQGPSPLDLNTELPYQSTMKRKVRKKKKKGTITANVAGTKFEIVRLVIDEM
Sbjct: 1   MPSLPQEGVIQGPSPLDLNTELPYQSTMKRKVRKKKKKGTITANVAGTKFEIVRLVIDEM 60

Query: 61  GFMKTPDEDETSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDFLARNMTKMIKS 120
           GFMKTPDEDETSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDFLARNMTKMIKS
Sbjct: 61  GFMKTPDEDETSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDFLARNMTKMIKS 120

Query: 121 RPLDYTFVPRTWIFPAEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKLP 180
           RPLDYTFVPRTWIFPAEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKLP
Sbjct: 121 RPLDYTFVPRTWIFPAEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKLP 180

Query: 181 SQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESN 240
           SQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESN
Sbjct: 181 SQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESN 240

Query: 241 LTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHDVAKFWSDISELVV 300
           LTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHDVAKFWSDISELVV
Sbjct: 241 LTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHDVAKFWSDISELVV 300

Query: 301 KTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQ 360
           KTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQ
Sbjct: 301 KTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQ 360

Query: 361 KIDYDVKRGVLLNALKLLNIRTSDKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQR 420
           KIDYDVKRGVLLNALKLLNIRTSDKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQR
Sbjct: 361 KIDYDVKRGVLLNALKLLNIRTSDKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQR 420

Query: 421 HQLERRKEELKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTF 480
           HQLERRKEELKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTF
Sbjct: 421 HQLERRKEELKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTF 480

Query: 481 LSGRAASFQRELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPKPLCSMPESTEI 540
           LSGRAASFQRELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPKPLCSMPESTEI
Sbjct: 481 LSGRAASFQRELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPKPLCSMPESTEI 540

Query: 541 MKRPKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQVTYNLKPSNHYKLIQQPSSIRR 600
           MKRPKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQVTYNLKPSNHYKLIQQPSSIRR
Sbjct: 541 MKRPKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQVTYNLKPSNHYKLIQQPSSIRR 600

Query: 601 SVSCPRSISAQSPSSGDTRPFSAQQMISVSRPTSASRSHSLNRASSYMRHLPHSNDACST 660
           SVSCPRSISAQSPSSGDTRPFSAQQMISVSRPTSASRSHSLNRASSYMRHLPHSNDACST
Sbjct: 601 SVSCPRSISAQSPSSGDTRPFSAQQMISVSRPTSASRSHSLNRASSYMRHLPHSNDACST 660

Query: 661 NSQVSESLRQLKTKEQEDDLTSQTLFVLKDMKIRFPGKSDAESELLIEDIIDNWKYHKTK 720
           NSQVSESLRQLKTKEQEDDLTSQTLFVLKDMKIRFPGKSDAESELLIEDIIDNWKYHKTK
Sbjct: 661 NSQVSESLRQLKTKEQEDDLTSQTLFVLKDMKIRFPGKSDAESELLIEDIIDNWKYHKTK 720

Query: 721 VASYWLIKLDSVKQRKVLDIVKTSIRTVLPRIWKVPDVEEVNLYRIFNRVFNRLLWSRGQ 780
           VASYWLIKLDSVKQRKVLDIVKTSIRTVLPRIWKVPDVEEVNLYRIFNRVFNRLLWSRGQ
Sbjct: 721 VASYWLIKLDSVKQRKVLDIVKTSIRTVLPRIWKVPDVEEVNLYRIFNRVFNRLLWSRGQ 780

Query: 781 GLWNCFCDSGSSWESIFNKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYATDKRGSLSGI 840
           GLWNCFCDSGSSWESIFNKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYATDKRGSLSGI
Sbjct: 781 GLWNCFCDSGSSWESIFNKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYATDKRGSLSGI 840

Query: 841 GPDWGNSRYLLPGSTQFFLRTPTYNLKYNSPGMTRSNVLFTSRYGHL 887
           GPDWGNSRYLLPGSTQFFLRTPTYNLKYNSPGMTRSNVLFTSRYGHL
Sbjct: 841 GPDWGNSRYLLPGSTQFFLRTPTYNLKYNSPGMTRSNVLFTSRYGHL 887


>gi|195963418 tubulin tyrosine ligase-like family, member 6 isoform
           1 [Homo sapiens]
          Length = 891

 Score =  372 bits (955), Expect = e-103
 Identities = 198/497 (39%), Positives = 297/497 (59%), Gaps = 33/497 (6%)

Query: 33  RKKKKKGTITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDSAVQQEKISELQNY 92
           +KK+KK  +  N++  ++E VR    + GF +  ++D+ + L W D +V  E++ E+++Y
Sbjct: 101 KKKRKKKRLVINLSSCRYESVRRAAQQYGFREGGEDDDWT-LYWTDYSVSLERVMEMKSY 159

Query: 93  QRINHFPGMGEICRKDFLARNMTKMIKSRPLDYTFVPRTWIFPAEYTQFQNYVKELKKKR 152
           Q+INHFPGM EICRKD LARNM++M+K  P D+ F PRTW  PA++   Q Y     + R
Sbjct: 160 QKINHFPGMSEICRKDLLARNMSRMLKMFPKDFRFFPRTWCLPADWGDLQTY----SRSR 215

Query: 153 KQKTFIVKPANGAMGHGISLIRNGDKLPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTS 212
           K KT+I KP +G  G GI + R   ++   + +I Q YI KPF+++G+KFDLRIY+LVTS
Sbjct: 216 KNKTYICKPDSGCQGKGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYVLVTS 275

Query: 213 CDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNEHFERDETENKGSKR 272
           CDPL+IF+Y++GL R  T  Y  P   NL  + MHLTNYS+NKH+ +F RD   + GSKR
Sbjct: 276 CDPLRIFVYNEGLARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFSRD--AHSGSKR 333

Query: 273 SIKWFTEFLQANQHDVAKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEV 332
            +  F+ +L+ + ++V + W DI ++++KTLI A P + H Y  C P       S CFE+
Sbjct: 334 KLSTFSAYLEDHSYNVEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHT--LNSACFEI 391

Query: 333 LGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRRNLAKQ 392
           LGFDILLD KLKPWLLE+N +PSF TD ++D +VK G+L + L L+N+ + DK++ L ++
Sbjct: 392 LGFDILLDHKLKPWLLEVNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEE 451

Query: 393 KAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKE-RLAQVRKQISREEHENRHM 451
           +   Q                  + QQ    E R EE K  R  Q++K    E +E  + 
Sbjct: 452 RQRGQ------------------FLQQCCSREMRIEEAKGFRAVQLKK---TETYEKENC 490

Query: 452 GNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRA-ASFQRELNNPLKRMKEEDILDLLEQ 510
           G +R IYP  +    EK+       FQ  ++ RA   + R+L   L+  +E+    + ++
Sbjct: 491 GGFRLIYPSLNSEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKK 550

Query: 511 CEIDDEKLMGKTTKTRG 527
            E+  E   G+  + +G
Sbjct: 551 VEMQGES-AGEQVRKKG 566


>gi|75677580 tubulin tyrosine ligase-like family, member 13 [Homo
           sapiens]
          Length = 459

 Score =  352 bits (902), Expect = 1e-96
 Identities = 165/369 (44%), Positives = 241/369 (65%), Gaps = 7/369 (1%)

Query: 33  RKKKKKGTITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDSAVQQEKISELQNY 92
           ++++K+ ++  N+   K+E VR      G +K   EDE   L W D AV  E++ +++ +
Sbjct: 80  KRRRKRRSLAINLTNCKYESVRRAAQMCG-LKEVGEDEEWTLYWTDCAVSLERVMDMKRF 138

Query: 93  QRINHFPGMGEICRKDFLARNMTKMIKSRPLDYTFVPRTWIFPAEYTQFQNYVKELKKKR 152
           Q+INHFPGM EICRKD LARN+ +M K  P +Y   PRTW  PA+Y  FQ+Y ++    R
Sbjct: 139 QKINHFPGMTEICRKDLLARNLNRMYKLYPSEYNIFPRTWCLPADYGDFQSYGRQ----R 194

Query: 153 KQKTFIVKPANGAMGHGISLIRNGDKLPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTS 212
           K +T+I KP +G  G GI + RN  ++   +H+I Q+YI KP L++G+KFD+R+Y+L+TS
Sbjct: 195 KARTYICKPDSGCQGRGIFITRNPREIKPGEHMICQQYISKPLLIDGFKFDMRVYVLITS 254

Query: 213 CDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNEHFERDETENKGSKR 272
           CDPL+IF Y +GL R  T  Y+ P+ +NL  + MHLTNY++NKHNE+F RD     GSKR
Sbjct: 255 CDPLRIFTYEEGLARFATTPYMEPSHNNLDNVCMHLTNYAINKHNENFVRDGA--VGSKR 312

Query: 273 SIKWFTEFLQANQHDVAKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEV 332
            +     +LQ + ++  + W DI ++++KT+I A   + H YR C P    G    CFE+
Sbjct: 313 KLSTLNIWLQEHSYNPGELWGDIEDIIIKTIISAHSVLRHNYRTCFPQYLNGGTCACFEI 372

Query: 333 LGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRRNLAKQ 392
           LGFDILLD KLKPWLLE+N +PSF TD  +D +VK  +L +A+ L+N+R  DKR+ + + 
Sbjct: 373 LGFDILLDHKLKPWLLEVNHSPSFTTDSCLDQEVKDALLCDAMTLVNLRGCDKRKVMEED 432

Query: 393 KAEAQRRLY 401
           K   + RL+
Sbjct: 433 KRRVKERLF 441


>gi|50658079 tubulin tyrosine ligase-like family, member 5 [Homo
           sapiens]
          Length = 1281

 Score =  216 bits (549), Expect = 1e-55
 Identities = 155/580 (26%), Positives = 273/580 (47%), Gaps = 37/580 (6%)

Query: 27  TMKRKVRKKKKKGTITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDSAVQQEKI 86
           T    +R   ++  ++  +  T   +VR ++   GF +        NL+W  S ++   +
Sbjct: 51  TKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVHPSSTDYNLMWTGSHLKPFLL 110

Query: 87  SELQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPLD-YTFVPRTWIFPAEYTQFQNYV 145
             L   Q++NHFP   E+ RKD L +N+ +M  +     +  +P+T++ PAEY +F N  
Sbjct: 111 RTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCN-- 168

Query: 146 KELKKKRKQKTFIVKPANGAMGHGISLIRNGDKLPSQDHLIVQEYIEKPFLMEGYKFDLR 205
                 + +  +IVKP   + G G+ LI N +++  +++++V  YI  P L++ +KFD+R
Sbjct: 169 ---SYSKDRGPWIVKPVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVR 225

Query: 206 IYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNEHF---ER 262
           +Y+LVTS DPL I+LY +GL R  T +Y      N+   +MHLTNYSVNK +  +   + 
Sbjct: 226 LYVLVTSYDPLVIYLYEEGLARFATVRY-DQGAKNIRNQFMHLTNYSVNKKSGDYVSCDD 284

Query: 263 DETENKGSKRSIKWFTEFLQANQHDVAKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQP 322
            E E+ G+K S+     +L+    D     + + +L++KT+I AE  +  A +   P   
Sbjct: 285 PEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIISAELAIATACKTFVP--- 341

Query: 323 PGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRT 382
               S CFE+ GFD+L+D  LKPWLLE+N +PS   D  +D  +K  ++ +   ++    
Sbjct: 342 --HRSSCFELYGFDVLIDSTLKPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVC 399

Query: 383 SDKRRNLAKQKA----EAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLA--- 435
            D  +  + +      E+ RR   Q   +R  P S+   + ++ +   +E+   +L    
Sbjct: 400 QDPAQRASTRPIYPTFESSRRNPFQKP-QRCRPLSASDAEMKNLVGSAREKGPGKLGGSV 458

Query: 436 -----QVRKQISREEHENRHMGNYRRIYPPED------KALLEKYENLLAVAFQTFLSGR 484
                +  K + R + EN   G + RI+P  +        L  K      +A + F    
Sbjct: 459 LGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRM 518

Query: 485 AASFQRELNNPLKRMKEEDILDLLEQ--CEIDDEKLMGKTTKTRGPKPLCS-MPESTEIM 541
            A    EL       K +    L E+    ++  K   ++++ R  +P    + +  E+ 
Sbjct: 519 TADGAPELKIESLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMN 578

Query: 542 KRPKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQVTY 581
            + +  S +    +  +  E  E  +EE     RE Q  Y
Sbjct: 579 VKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKY 618


>gi|212720861 tubulin tyrosine ligase-like family, member 11 a [Homo
           sapiens]
          Length = 800

 Score =  205 bits (522), Expect = 1e-52
 Identities = 136/410 (33%), Positives = 209/410 (50%), Gaps = 29/410 (7%)

Query: 5   PQEGVIQGPSPLDLNTELPYQSTMKRKVRKKKKKGTITANVAGTKFEIVRLVIDEMGFMK 64
           P +G+     P D        S         ++  T+ ++ A T  + +++ I ++ + +
Sbjct: 185 PVQGLCPHGKPRDKGRSCKRSSGHGSGENGSQRPVTVDSSKARTSLDALKISIRQLKWKE 244

Query: 65  TP-DEDETSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPL 123
            P       ++ W   +     I   Q    +N FPGM E+ RK  L+R +  M    P 
Sbjct: 245 FPFGRRLPCDIYWHGVSFHDNDIFSGQ----VNKFPGMTEMVRKITLSRAVRTMQNLFPE 300

Query: 124 DYTFVPRTWIFPAEYTQFQNYVKELKKKRK--QKTFIVKPANGAMGHGISLIRNGDKLPS 181
           +Y F PR+WI P E+  F   V+ +K      + TFIVKP  G  G GI LI++   +  
Sbjct: 301 EYNFYPRSWILPDEFQLFVAQVQMVKDDDPSWKPTFIVKPDGGCQGDGIYLIKDPSDIRL 360

Query: 182 QDHL-----IVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPP 236
              L     +VQEYI KP L++  KFD+R+Y+L+ S DPL+I++  DGL R  TE Y  P
Sbjct: 361 AGTLQSRPAVVQEYICKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEP 420

Query: 237 NESNLTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHDVAKFWSDIS 296
              NL +++MHLTNYS+N H+ +F   ++ + GSKR+       L +   D+ K WSDI 
Sbjct: 421 TPKNLHRIFMHLTNYSLNIHSGNFIHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDII 480

Query: 297 ELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSF 356
            +V+KT+I   P +   Y+   P   PG    CF++LGFDILL + LKP LLE+N  PS 
Sbjct: 481 SVVIKTVIALTPELKVFYQSDIPTGRPG--PTCFQILGFDILLMKNLKPILLEVNANPSM 538

Query: 357 GTDQK--------------IDYDVKRGVLLNALKLLNIRTSDKRRNLAKQ 392
             + +              +D +VK  V+ + L+L++     KR N ++Q
Sbjct: 539 RIEHEHELSPGVFENVPSLVDEEVKVAVIRDTLRLMD-PLKKKRENQSQQ 587


>gi|217330594 tubulin tyrosine ligase-like family, member 4 [Homo
           sapiens]
          Length = 1199

 Score =  201 bits (510), Expect = 3e-51
 Identities = 116/295 (39%), Positives = 177/295 (60%), Gaps = 19/295 (6%)

Query: 89  LQNYQRINHFPGMGEICRKDFLARNMTKMIKSR--PLDYTFVPRTWIFPAEYTQFQNYVK 146
           ++ +Q++NHFPG  +I RKD L RN+++M +SR    +++F P+++I P    Q    ++
Sbjct: 653 IREHQKLNHFPGSFQIGRKDRLWRNLSRM-QSRFGKKEFSFFPQSFILP----QDAKLLR 707

Query: 147 ELKKKRKQKTFIVKPANGAMGHGISLIRNGDKLPSQDHLIVQEYIEKPFLMEGYKFDLRI 206
           +  +   ++ +IVKP   A G GI +I    +LP +  L+VQ Y+ KP+L+ G KFDLRI
Sbjct: 708 KAWESSSRQKWIVKPPASARGIGIQVIHKWSQLPKRRPLLVQRYLHKPYLISGSKFDLRI 767

Query: 207 YILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNEHFE--RDE 264
           Y+ VTS DPL+I+L+ DGLVR  + KY P  +S L   +MHLTNYSVNK N  ++   DE
Sbjct: 768 YVYVTSYDPLRIYLFSDGLVRFASCKYSPSMKS-LGNKFMHLTNYSVNKKNAEYQANADE 826

Query: 265 TENKGSKRSIKWFTEFLQANQHDVAKFWSDISELVVKTLIVAEPHVLHAYRMC--RPGQP 322
              +G K ++K    +L     +    W  I ++VVKT+I +EP+V    +M   RP   
Sbjct: 827 MACQGHKWALKALWNYLSQKGVNSDAIWEKIKDVVVKTIISSEPYVTSLLKMYVRRPYS- 885

Query: 323 PGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKL 377
                 C E+ GFDI+LD  LKPW+LE+N +PS  +   +D  +K  ++ + L L
Sbjct: 886 ------CHELFGFDIMLDENLKPWVLEVNISPSLHSSSPLDISIKGQMIRDLLNL 934


>gi|99028883 tubulin tyrosine ligase-like family, member 2 [Homo
           sapiens]
          Length = 592

 Score =  186 bits (473), Expect = 6e-47
 Identities = 120/362 (33%), Positives = 190/362 (52%), Gaps = 29/362 (8%)

Query: 52  IVRLVIDEMGFMKTPDEDETS---NLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKD 108
           +V+ V+ E G+ K   +++ +   NL W  S+ +  + + ++ +Q++NH PG  ++ RKD
Sbjct: 98  VVQSVLLERGWNKFDKQEQNAEDWNLYWRTSSFRMTEHNSVKPWQQLNHHPGTTKLTRKD 157

Query: 109 FLARNMTKMIKSRPLD-YTFVPRTWIFPAEYTQF-QNYVKELKKK-RKQKTFIVKPANGA 165
            LA+++  M +      Y F+P T++ P +YT+F   Y +E +    K   +I KPA  +
Sbjct: 158 CLAKHLKHMRRMYGTSLYQFIPLTFVMPNDYTKFVAEYFQERQMLGTKHSYWICKPAELS 217

Query: 166 MGHGISLIRNGDKLPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGL 225
            G GI +  +       D  IVQ+YI  P L+  YK DLRIY+ VT   PL I++Y +GL
Sbjct: 218 RGRGILIFSDFKDFIFDDMYIVQKYISNPLLIGRYKCDLRIYVCVTGFKPLTIYVYQEGL 277

Query: 226 VRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNEHFER-DETENKGSKRSIKWFTEFLQAN 284
           VR  TEK+   + SNL   Y HLTN S+NK    +E+  E    G K ++  F  +L++ 
Sbjct: 278 VRFATEKF---DLSNLQNNYAHLTNSSINKSGASYEKIKEVIGHGCKWTLSRFFSYLRSW 334

Query: 285 QHDVAKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLK 344
             D    W  I  +V+ T++   P V  A             + CFE+ GFDIL+D  LK
Sbjct: 335 DVDDLLLWKKIHRMVILTILAIAPSVPFA-------------ANCFELFGFDILIDDNLK 381

Query: 345 PWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRRNLAKQKAEAQRRLYGQN 404
           PWLLE+N +P+   D   D  VKR ++ + + L+ +        L  +  EA    +G +
Sbjct: 382 PWLLEVNYSPALTLDCSTDVLVKRKLVHDIIDLIYL------NGLRNEGREASNATHGNS 435

Query: 405 SI 406
           +I
Sbjct: 436 NI 437


>gi|89363028 tubulin tyrosine ligase-like family, member 11 b [Homo
           sapiens]
          Length = 538

 Score =  171 bits (434), Expect = 2e-42
 Identities = 111/336 (33%), Positives = 170/336 (50%), Gaps = 14/336 (4%)

Query: 5   PQEGVIQGPSPLDLNTELPYQSTMKRKVRKKKKKGTITANVAGTKFEIVRLVIDEMGFMK 64
           P +G+     P D        S         ++  T+ ++ A T  + +++ I ++ + +
Sbjct: 185 PVQGLCPHGKPRDKGRSCKRSSGHGSGENGSQRPVTVDSSKARTSLDALKISIRQLKWKE 244

Query: 65  TP-DEDETSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPL 123
            P       ++ W   +     I   Q    +N FPGM E+ RK  L+R +  M    P 
Sbjct: 245 FPFGRRLPCDIYWHGVSFHDNDIFSGQ----VNKFPGMTEMVRKITLSRAVRTMQNLFPE 300

Query: 124 DYTFVPRTWIFPAEYTQFQNYVKELKKKRK--QKTFIVKPANGAMGHGISLIRNGDKLPS 181
           +Y F PR+WI P E+  F   V+ +K      + TFIVKP  G  G GI LI++   +  
Sbjct: 301 EYNFYPRSWILPDEFQLFVAQVQMVKDDDPSWKPTFIVKPDGGCQGDGIYLIKDPSDIRL 360

Query: 182 QDHL-----IVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPP 236
              L     +VQEYI KP L++  KFD+R+Y+L+ S DPL+I++  DGL R  TE Y  P
Sbjct: 361 AGTLQSRPAVVQEYICKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEP 420

Query: 237 NESNLTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHDVAKFWSDIS 296
              NL +++MHLTNYS+N H+ +F   ++ + GSKR+       L +   D+ K WSDI 
Sbjct: 421 TPKNLHRIFMHLTNYSLNIHSGNFIHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDII 480

Query: 297 ELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEV 332
            +V+KT+I   P +   Y+   P   PG    CF+V
Sbjct: 481 SVVIKTVIALTPELKVFYQSDIPTGRPG--PTCFQV 514


>gi|11068135 tubulin tyrosine ligase-like family, member 1 [Homo
           sapiens]
          Length = 423

 Score =  142 bits (357), Expect = 2e-33
 Identities = 99/347 (28%), Positives = 165/347 (47%), Gaps = 59/347 (17%)

Query: 68  EDETSNLIWCDSAVQQEKIS-----ELQNYQRINHFPGMGEICRKDFLARNMTKMIKS-- 120
           E+E  N  W      +   S      L + Q +NHFP   E+ RKD + +N+ +  K   
Sbjct: 30  ENEDWNFYWMSVQTIRNVFSVEAGYRLSDDQIVNHFPNHYELTRKDLMVKNIKRYRKELE 89

Query: 121 -------------RPLDYTFVPRTWIFPAEYTQFQNYVKELKKKRKQKTFIVKPANGAMG 167
                        + L   FVP T++ PA+Y  F   V+E +K     T+I+KP   A G
Sbjct: 90  KEGSPLAEKDENGKYLYLDFVPVTYMLPADYNLF---VEEFRKS-PSSTWIMKPCGKAQG 145

Query: 168 HGISLIRNGDKLP---------------SQDHLIVQEYIEKPFLMEGYKFDLRIYILVTS 212
            GI LI    ++                +++  ++  YI  P L+ G KFDLR+Y+LV++
Sbjct: 146 KGIFLINKLSQIKKWSRDSKTSSFVSQSNKEAYVISLYINNPLLIGGRKFDLRLYVLVST 205

Query: 213 CDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNEHFERDETENKGSKR 272
             PL+ ++Y  G  R  T KY  P+ S L  +++HLTN ++ KH E    D     G K 
Sbjct: 206 YRPLRCYMYKLGFCRFCTVKY-TPSTSELDNMFVHLTNVAIQKHGE----DYNHIHGGKW 260

Query: 273 SIKWFTEFLQA--NQHDVAKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCF 330
           ++     +L++   +   +K + +I  ++V++L    P +              ++  CF
Sbjct: 261 TVSNLRLYLESTRGKEVTSKLFDEIHWIIVQSLKAVAPVM-------------NNDKHCF 307

Query: 331 EVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKL 377
           E  G+DI++D KLKPWL+E+N +PS  +    D  +K  ++ + L +
Sbjct: 308 ECYGYDIIIDDKLKPWLIEVNASPSLTSSTANDRILKYNLINDTLNI 354


>gi|195963416 tubulin tyrosine ligase-like family, member 6 isoform
           2 [Homo sapiens]
          Length = 584

 Score =  140 bits (354), Expect = 4e-33
 Identities = 86/258 (33%), Positives = 137/258 (53%), Gaps = 26/258 (10%)

Query: 272 RSIKWFTEFLQANQHDVAKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFE 331
           R +  F+ +L+ + ++V + W DI ++++KTLI A P + H Y  C P       S CFE
Sbjct: 26  RKLSTFSAYLEDHSYNVEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHT--LNSACFE 83

Query: 332 VLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRRNLAK 391
           +LGFDILLD KLKPWLLE+N +PSF TD ++D +VK G+L + L L+N+ + DK++ L +
Sbjct: 84  ILGFDILLDHKLKPWLLEVNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEE 143

Query: 392 QKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKE-RLAQVRKQISREEHENRH 450
           ++   Q                  + QQ    E R EE K  R  Q++K    E +E  +
Sbjct: 144 ERQRGQ------------------FLQQCCSREMRIEEAKGFRAVQLKK---TETYEKEN 182

Query: 451 MGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRA-ASFQRELNNPLKRMKEEDILDLLE 509
            G +R IYP  +    EK+       FQ  ++ RA   + R+L   L+  +E+    + +
Sbjct: 183 CGGFRLIYPSLNSEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKK 242

Query: 510 QCEIDDEKLMGKTTKTRG 527
           + E+  E   G+  + +G
Sbjct: 243 KVEMQGES-AGEQVRKKG 259


>gi|56606131 tubulin tyrosine ligase-like family, member 9 [Homo
           sapiens]
          Length = 439

 Score =  127 bits (320), Expect = 3e-29
 Identities = 104/382 (27%), Positives = 182/382 (47%), Gaps = 75/382 (19%)

Query: 29  KRKVRKKKKKGTITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDSAVQQEKISE 88
           K K R+++        +  T  +++R      G+++  DE E  +  WCD +  +E    
Sbjct: 34  KGKEREQRASIRFKTTLMNTLMDVLR---HRPGWVEVKDEGEW-DFYWCDVSWLRENFDH 89

Query: 89  --LQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPLDY--------TFVPRTWIFPAEY 138
             +  + RI+HF    E+ RK+++ +N+ +  K    +          F P+T+  P EY
Sbjct: 90  TYMDEHVRISHFRNHYELTRKNYMVKNLKRFRKQLEREAGKLEAAKCDFFPKTFEMPCEY 149

Query: 139 TQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRN-----------------GDKLPS 181
             F   V+E +K     T+I+KP   + G GI L R                   D +P 
Sbjct: 150 HLF---VEEFRKN-PGITWIMKPVARSQGKGIFLFRRLKDIVDWRKDTRSSDDQKDDIPV 205

Query: 182 QDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNL 241
           +++ + Q YIE P+L+ G KFDLR+Y+LV S       ++ + L+  G  +         
Sbjct: 206 ENY-VAQRYIENPYLIGGRKFDLRVYVLVMS-------VFAECLLWSGHRRQD------- 250

Query: 242 TQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHD---VAKFWSDISEL 298
               +HLTN +V K +  +       KG K +++ F ++L A++H    V   + DI  +
Sbjct: 251 ----VHLTNVAVQKTSPDYH----PKKGCKWTLQRFRQYL-ASKHGPEAVETLFRDIDNI 301

Query: 299 VVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGT 358
            VK+L   +  ++             S+  CFE+ G+DIL+D+ LKPWLLE+N +PS   
Sbjct: 302 FVKSLQSVQKVII-------------SDKHCFELYGYDILIDQDLKPWLLEVNASPSLTA 348

Query: 359 DQKIDYDVKRGVLLNALKLLNI 380
             + DY++K  +L + L ++++
Sbjct: 349 SSQEDYELKTCLLEDTLHVVDM 370


>gi|109134340 tubulin tyrosine ligase-like family, member 3 [Homo
           sapiens]
          Length = 772

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 70/263 (26%), Positives = 116/263 (44%), Gaps = 37/263 (14%)

Query: 140 QFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIR---------NGDKLPSQD-HLIVQE 189
           Q Q  V ++  +  +  +IVKP   + G GI  +          NG+ +  +D   +VQ+
Sbjct: 263 QLQAVVPQIDMEGDRNIWIVKPGAKSRGRGIMCMDHLEEMLKLVNGNPVVMKDGKWVVQK 322

Query: 190 YIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLT 249
           YIE+P L+ G KFDLR + LVT  +PL ++ Y D  +R  T+ +   N  N     +HL 
Sbjct: 323 YIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDN----SVHLC 378

Query: 250 NYSVNKHNEHFERDETENKGSKRSI-----KWFTEFLQANQHDVA--KFWSDISELVVKT 302
           N S+ KH         EN   +  +      W ++  QA+  ++     WS I    +K 
Sbjct: 379 NNSIQKH--------LENSCHRHPLLPPDNMWSSQRFQAHLQEMGAPNAWSTIIVPGMKD 430

Query: 303 LIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKI 362
            ++           CR           FE+ G D +     +PWL+EIN +P+      +
Sbjct: 431 AVIHALQTSQDTVQCR--------KASFELYGADFVFGEDFQPWLIEINASPTMAPSTAV 482

Query: 363 DYDVKRGVLLNALKLLNIRTSDK 385
              +  GV  + L+++  R  D+
Sbjct: 483 TARLCAGVQADTLRVVIDRMLDR 505


>gi|24308516 tubulin tyrosine ligase [Homo sapiens]
          Length = 377

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 81/316 (25%), Positives = 149/316 (47%), Gaps = 61/316 (19%)

Query: 93  QRINHFPGMGEICRKDFLARNMTKMIKSRPL----------DYTFVP---RTWIFPAEY- 138
           Q +N++ G  ++CRK     ++ K+IK+ P            Y   P   +T + PA+  
Sbjct: 60  QLVNYYRGADKLCRK----ASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNG 115

Query: 139 ----------TQFQNYVKELKKKRKQ---KTFIVKPANGAMGHGISLIRNGDKL------ 179
                      + + ++    +K++      +I K + GA G GI +     +L      
Sbjct: 116 IQPPISNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDN 175

Query: 180 PSQDHLIVQEYIEKPFLME-GY-KFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPN 237
             Q H ++Q+Y+E P L+E G+ KFD+R ++LV       I+LY +G++R  +E Y   N
Sbjct: 176 QGQVH-VIQKYLEHPLLLEPGHRKFDIRSWVLVDH--QYNIYLYREGVLRTASEPYHVDN 232

Query: 238 ESNLTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQA--NQHDVAKFWSDI 295
             + T    HLTN+ + K  E+ +      +G++   K F ++L +  N    +     I
Sbjct: 233 FQDKT---CHLTNHCIQK--EYSKNYGKYEEGNEMFFKEFNQYLTSALNITLESSILLQI 287

Query: 296 SELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPS 355
             ++   L+  EP +   +    P Q        F++ GFD ++D +LK WL+E+N AP+
Sbjct: 288 KHIIRNCLLSVEPAISTKHL---PYQS-------FQLFGFDFMVDEELKVWLIEVNGAPA 337

Query: 356 FGTDQKIDYDVKRGVL 371
               QK+  ++ +G++
Sbjct: 338 CA--QKLYAELCQGIV 351


>gi|194239681 tubulin tyrosine ligase-like family, member 10 isoform
           1 [Homo sapiens]
          Length = 673

 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 66/272 (24%), Positives = 115/272 (42%), Gaps = 53/272 (19%)

Query: 142 QNYVKELKKKRKQ--------KTFIVKPANGAMGHGISLIRNGDKLPS------------ 181
           + Y  +LK +R+         + +I KP     G GI L+RN +++ +            
Sbjct: 287 ETYRLDLKHEREAFFTLFDETQIWICKPTASNQGKGIFLLRNQEEVAALQAKTRSMEDDP 346

Query: 182 ---------QDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEK 232
                        +VQ YI+ P L++G KFD+R Y+L+    P  IF  H G  R+    
Sbjct: 347 IHHKTPFRGPQARVVQRYIQNPLLVDGRKFDVRSYLLIACTTPYMIFFGH-GYARLTLSL 405

Query: 233 YIPPNESNLTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHDVAKFW 292
           Y P    + + L  HLTN  + K +  +   +     S   +  +          +AK W
Sbjct: 406 YDP----HSSDLGGHLTNQFMQKKSPLYMLLKEHTVWSMEHLNRYISDTFWKARGLAKDW 461

Query: 293 ------SDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPW 346
                   + +++    + A+P +      C+ G         F+++G D L+D   K W
Sbjct: 462 VFTTLKKRMQQIMAHCFLAAKPKL-----DCKLGY--------FDLIGCDFLIDDNFKVW 508

Query: 347 LLEINRAPSFGTDQKIDYDVKRGVLLNALKLL 378
           LLE+N  P+  T+ ++  +V  GV++  L L+
Sbjct: 509 LLEMNSNPALHTNCEVLKEVIPGVVIETLDLV 540


>gi|122937293 tubulin tyrosine ligase-like family, member 8 [Homo
           sapiens]
          Length = 834

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 65/246 (26%), Positives = 107/246 (43%), Gaps = 35/246 (14%)

Query: 157 FIVKPANGAMGHGIS-------LIRNGDKLPSQDH-------LIVQEYIEKPFLMEGYKF 202
           +I+KPA  + G G S        +    +L + DH        +VQ+YIE P L+   KF
Sbjct: 331 WIIKPAAKSRGRGESPDIVCMDRVEEILELAAADHPLSRDNKWVVQKYIETPLLICDTKF 390

Query: 203 DLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNEHFER 262
           D+R + LVT  +PL I+ Y +  +R  T+++      +     +HL N +V K   + + 
Sbjct: 391 DIRQWFLVTDWNPLTIWFYKESYLRFSTQRF----SLDKLDSAIHLCNNAVQK---YLKN 443

Query: 263 DETENKGSKRSIKW----FTEFLQANQHDVAKFWSDISELVVKTLIVAEPHVLHAYRMCR 318
           D   +        W    F E+LQ         W  +    +K  I       HA ++ +
Sbjct: 444 DVGRSPLLPAHNMWTSTRFQEYLQRQGRGAV--WGSVIYPSMKKAIA------HAMKVAQ 495

Query: 319 PGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLL 378
               P   S  FE+ G D +L R  +PWL+EIN +P+      +   +   V  + +K+ 
Sbjct: 496 DHVEPRKNS--FELYGADFVLGRDFRPWLIEINSSPTMHPSTPVTAQLCAQVQEDTIKVA 553

Query: 379 NIRTSD 384
             R+ D
Sbjct: 554 VDRSCD 559


>gi|194239678 tubulin tyrosine ligase-like family, member 10 isoform
           2 [Homo sapiens]
          Length = 404

 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 40/143 (27%), Positives = 62/143 (43%), Gaps = 34/143 (23%)

Query: 142 QNYVKELKKKRKQ--------KTFIVKPANGAMGHGISLIRNGDKLPS------------ 181
           + Y  +LK +R+         + +I KP     G GI L+RN +++ +            
Sbjct: 214 ETYRLDLKHEREAFFTLFDETQIWICKPTASNQGKGIFLLRNQEEVAALQAKTRSMEDDP 273

Query: 182 ---------QDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEK 232
                        +VQ YI+ P L++G KFD+R Y+L+    P  IF  H G  R+    
Sbjct: 274 IHHKTPFRGPQARVVQRYIQNPLLVDGRKFDVRSYLLIACTTPYMIFFGH-GYARLTLSL 332

Query: 233 YIPPNESNLTQLYMHLTNYSVNK 255
           Y P    + + L  HLTN  + K
Sbjct: 333 YDP----HSSDLGGHLTNQFMQK 351


>gi|11056036 tubulin tyrosine ligase-like family, member 12 [Homo
           sapiens]
          Length = 644

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 48/172 (27%), Positives = 76/172 (44%), Gaps = 18/172 (10%)

Query: 62  FMKTPDEDETSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDFLARNMTKMIKSR 121
           F  T  E +   L          K+S+ +    +N FP    +  KD LA    +     
Sbjct: 323 FTLTQSEADADILFNFSHFKDYRKLSQERPGVLLNQFPCENLLTVKDCLASIARRA--GG 380

Query: 122 PLDYTFVPRTWIFPAEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGI-------SLIR 174
           P    ++PRT+    E  QF +Y ++ ++  +   +I KP N A            S+IR
Sbjct: 381 PEGPPWLPRTFNLRTELPQFVSYFQQRERWGEDNHWICKPWNLARSLDTHVTKSLHSIIR 440

Query: 175 NGDKLPSQDHLIVQEYIEKP--FLMEGY---KFDLRIYILVTSCDPLKIFLY 221
           + +  P     +V +YIE P  FL E     KFD+R  +L+ S  PL++F+Y
Sbjct: 441 HRESTPK----VVSKYIESPVLFLREDVGKVKFDIRYIVLLRSVRPLRLFVY 488


>gi|27734775 hypothetical protein LOC286499 [Homo sapiens]
          Length = 248

 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 3/137 (2%)

Query: 542 KRPKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQVTYNLKPSNHYKLIQQPSSIRRS 601
           ++ K C S SS  SS SSS S ++E EE +  KR K+       S+     +  S  + S
Sbjct: 97  RKKKSCRSSSSSSSSDSSSSSSDSEDEEKKQGKRRKKKKNRSYKSSQSSTHESESESKES 156

Query: 602 VSCPRSISAQSPSSGDTRPFSAQQMISVSRPTSASRSHSLNRASSYMRHL-PHSNDACST 660
           V   +    ++    D R  S ++    S P     S   +  S Y   +       C  
Sbjct: 157 VKKKKKSKDETEKEKDVRSLSKKR--KKSYPDDKPLSSESSSESDYEEDVQAKKKRRCEE 214

Query: 661 NSQVSESLRQLKTKEQE 677
             Q  E +++ K K+ +
Sbjct: 215 REQAKEKVKKKKKKQHK 231


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 76/357 (21%), Positives = 136/357 (38%), Gaps = 30/357 (8%)

Query: 378 LNIRTSDKRRN--LAKQKAEAQRRLYGQNSIKRLLPGS------SDWEQQRHQLERRKEE 429
           L ++  +K R+  L +Q+   +++L  Q   KR L            EQ+R   E+++ E
Sbjct: 357 LRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRE 416

Query: 430 LKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQ 489
            + R  Q R+Q  RE+ E R +    R    E++    + E       Q ++  +    Q
Sbjct: 417 REARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQ 476

Query: 490 RELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSS 549
           R L    +++ +E  + L  +    +E    +  + +  +    +       +RP    S
Sbjct: 477 RHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHS 536

Query: 550 DS---SYDSSSSSSESDENEKEEYQNKKREKQVTYNLKPSNHYKLIQQPSSIRRSVSCPR 606
                     S  S      K  Y+   R ++V    + +NH     Q     R +  P 
Sbjct: 537 QQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPV 596

Query: 607 SISAQSPSSGDT--------RPFSAQ----QMISVSRPTS-ASRSHSLNRAS-SYMRHLP 652
              ++S S+G++        RP   Q     + S+    S  SRSHS +  S  +  H  
Sbjct: 597 PSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHL 656

Query: 653 HSNDACSTNSQVSESLRQLKTKEQEDDLTSQTLFVLKD---MKIRFPGKSDAESELL 706
            S D C  +   SE L Q    + E    +Q  +   D   +  R P ++ + S +L
Sbjct: 657 RSQDPCPPSR--SEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVL 711


>gi|4758650 kinesin family member 5C [Homo sapiens]
          Length = 957

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 40/152 (26%), Positives = 72/152 (47%), Gaps = 17/152 (11%)

Query: 383 SDKRRNLAKQKAEAQRRLYGQNS--IKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQ 440
           S+++ N ++++  A + L  Q+   IK L     + EQ+R QLE  ++ L E LA++R Q
Sbjct: 615 SNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQ 674

Query: 441 -----ISREEHENRHMGNYRRIYPPED-KALLEKYENLLAVAFQTFLSGRAASFQRELNN 494
                +S ++ E  H+    R+   E+ K  LE+       A Q  LS      +     
Sbjct: 675 EKMHEVSFQDKEKEHL---TRLQDAEEMKKALEQQMESHREAHQKQLSRLRDEIEE---- 727

Query: 495 PLKRMKEEDILDLLEQCEIDDEKLMGKTTKTR 526
             K+   ++I DL ++ +++ EKL     K +
Sbjct: 728 --KQKIIDEIRDLNQKLQLEQEKLSSDYNKLK 757


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 44/196 (22%), Positives = 80/196 (40%), Gaps = 29/196 (14%)

Query: 509 EQCEIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDSSSSSSESDENEKE 568
           E+    +E+   K   T  PK       S    + P+  S DSS DS SSSSE +E +  
Sbjct: 428 EESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQG-SRDSSSDSDSSSSEEEEEKTS 486

Query: 569 EYQNKKREKQVTYNLKPSNHYKLIQQPSSIRRSVSCPRSISAQSPSSGDTRPFSAQQMIS 628
           +   KK+ ++V     PS       +P+S ++     ++ S+ S SS D           
Sbjct: 487 KSAVKKKPQKVAGGAAPS-------KPASAKKG----KAESSNSSSSDD----------- 524

Query: 629 VSRPTSASRSHSLNRASSYMRHLPHSNDACSTNSQVSESLRQLKTKEQEDDLTSQTLFVL 688
               +S      L    S     P +N   +  +Q  ++ +   ++E+E++     + V 
Sbjct: 525 ----SSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAK--NSEEEEEEKKKAAVVVS 578

Query: 689 KDMKIRFPGKSDAESE 704
           K   ++   +++A  E
Sbjct: 579 KSGSLKKRKQNEAAKE 594



 Score = 35.0 bits (79), Expect = 0.31
 Identities = 34/147 (23%), Positives = 54/147 (36%), Gaps = 4/147 (2%)

Query: 528 PKPLCSMPESTEIMKRPKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQVTYNLKPSN 587
           PKP  + P+    +   K  SS SS  SSSSS +S+E +      K   K+      P  
Sbjct: 200 PKPARAAPK----IANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVK 255

Query: 588 HYKLIQQPSSIRRSVSCPRSISAQSPSSGDTRPFSAQQMISVSRPTSASRSHSLNRASSY 647
                 + SS     S       + P      P+S+    S   P  +  +    +A   
Sbjct: 256 AATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEK 315

Query: 648 MRHLPHSNDACSTNSQVSESLRQLKTK 674
            + +  S D+   +   SE  ++  TK
Sbjct: 316 QQPVESSEDSSDESDSSSEEEKKPPTK 342



 Score = 30.0 bits (66), Expect = 9.9
 Identities = 36/164 (21%), Positives = 58/164 (35%), Gaps = 14/164 (8%)

Query: 509 EQCEIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDSSSSSSESDENEKE 568
           E  + DDE+   K    +G KP     ++      PK   S  S   SSS  E  +N+K 
Sbjct: 131 ESSDDDDEEDQKKQPVQKGVKPQAKAAKAP-----PKKAKSSDSDSDSSSEDEPPKNQKP 185

Query: 569 EYQNKKREKQVTYNLKPSNHYKLIQQPSSIRRSVSCPRSISAQSPSSGDTRPFSAQQMIS 628
           +      + Q     KP+        P       +   S S+ S SS D    S ++  +
Sbjct: 186 KITPVTVKAQTKAPPKPAR-----AAPKIANGKAASSSSSSSSSSSSDD----SEEEKAA 236

Query: 629 VSRPTSASRSHSLNRASSYMRHLPHSNDACSTNSQVSESLRQLK 672
            +   +  +   + +A       P    + S +S   E   Q K
Sbjct: 237 ATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKK 280


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 43/193 (22%), Positives = 83/193 (43%), Gaps = 25/193 (12%)

Query: 385 KRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQISRE 444
           KRR +A++ +  +R    Q   KR        E++R   E++KE+ +++  + R +  R+
Sbjct: 140 KRREMAREHSRRERDRLEQLERKR--------ERERKMREQQKEQREQKERERRAEERRK 191

Query: 445 EHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKRMKEEDI 504
           E E       RR      + + E Y + +  +  +    R    + EL +  K +KEE +
Sbjct: 192 ERE------ARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKM 245

Query: 505 --LDLLEQC-EIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDSSSSSSE 561
              DLL    +I D +    + ++   +      E  E          +   +  S+S E
Sbjct: 246 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE--------EEEEEEEEGSTSEE 297

Query: 562 SDENEKEEYQNKK 574
           S+E E+EE + ++
Sbjct: 298 SEEEEEEEEEEEE 310



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 45/207 (21%), Positives = 88/207 (42%), Gaps = 20/207 (9%)

Query: 385 KRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQR-HQLERRKE---ELKERLAQVRKQ 440
           +RR   +++ +  RR + +   + +    S  E+ R  QLER++E   +++E+  + R+Q
Sbjct: 120 ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 179

Query: 441 ISREEH--ENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKR 498
             RE    E R     RR      + + E Y + +  +  +    R    + EL +  K 
Sbjct: 180 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKP 239

Query: 499 MKEEDI--LDLLEQCE-IDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDS 555
           +KEE +   DLL   + I D +    + ++   +      E  E              + 
Sbjct: 240 VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE-----------EEEEE 288

Query: 556 SSSSSESDENEKEEYQNKKREKQVTYN 582
               S S+E+E+EE + ++ E++   N
Sbjct: 289 EEEGSTSEESEEEEEEEEEEEEETGSN 315


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 43/193 (22%), Positives = 83/193 (43%), Gaps = 25/193 (12%)

Query: 385 KRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQISRE 444
           KRR +A++ +  +R    Q   KR        E++R   E++KE+ +++  + R +  R+
Sbjct: 150 KRREMAREHSRRERDRLEQLERKR--------ERERKMREQQKEQREQKERERRAEERRK 201

Query: 445 EHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKRMKEEDI 504
           E E       RR      + + E Y + +  +  +    R    + EL +  K +KEE +
Sbjct: 202 ERE------ARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKM 255

Query: 505 --LDLLEQC-EIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDSSSSSSE 561
              DLL    +I D +    + ++   +      E  E          +   +  S+S E
Sbjct: 256 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE--------EEEEEEEEGSTSEE 307

Query: 562 SDENEKEEYQNKK 574
           S+E E+EE + ++
Sbjct: 308 SEEEEEEEEEEEE 320



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 45/207 (21%), Positives = 88/207 (42%), Gaps = 20/207 (9%)

Query: 385 KRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQR-HQLERRKE---ELKERLAQVRKQ 440
           +RR   +++ +  RR + +   + +    S  E+ R  QLER++E   +++E+  + R+Q
Sbjct: 130 ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 189

Query: 441 ISREEH--ENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKR 498
             RE    E R     RR      + + E Y + +  +  +    R    + EL +  K 
Sbjct: 190 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKP 249

Query: 499 MKEEDI--LDLLEQCE-IDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDS 555
           +KEE +   DLL   + I D +    + ++   +      E  E              + 
Sbjct: 250 VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE-----------EEEEE 298

Query: 556 SSSSSESDENEKEEYQNKKREKQVTYN 582
               S S+E+E+EE + ++ E++   N
Sbjct: 299 EEEGSTSEESEEEEEEEEEEEEETGSN 325


>gi|38569484 kinesin family member 21A [Homo sapiens]
          Length = 1661

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 34/142 (23%), Positives = 59/142 (41%), Gaps = 10/142 (7%)

Query: 383 SDKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQIS 442
           S+  + L     E QR    Q    RLL   S +E+Q  +L++   E+K+   ++ KQ+ 
Sbjct: 706 SEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMK 765

Query: 443 REEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKRMKEE 502
            E+ + R   + R     + K    K ++ L          R    Q+     + R K E
Sbjct: 766 EEQEKARLTESRRNREIAQLKKDQRKRDHQL----------RLLEAQKRNQEVVLRRKTE 815

Query: 503 DILDLLEQCEIDDEKLMGKTTK 524
           ++  L  Q     +K+ GK T+
Sbjct: 816 EVTALRRQVRPMSDKVAGKVTR 837


>gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]
          Length = 564

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 47/201 (23%), Positives = 81/201 (40%), Gaps = 14/201 (6%)

Query: 384 DKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQISR 443
           ++RR L +QK E  R        +R+    +D +++    ERR+   +ERL Q +++ S 
Sbjct: 5   ERRRELRRQKREEMRL-----EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59

Query: 444 EEHENRHMGNYRRIYPPEDKALL---EKYENLLAVAFQTFLSGRAASFQRELNNPLKRMK 500
            +  ++   N +   P E+        + E     AF   L+ R    Q+ L   L+R K
Sbjct: 60  GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119

Query: 501 EEDILDLLEQCEIDDEKLMGKTTK---TRGPKPLCSMPESTEIMKR---PKYCSSDSSYD 554
           E D         +   ++   T +   T   +   S  E  EI +     K    +   D
Sbjct: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179

Query: 555 SSSSSSESDENEKEEYQNKKR 575
           +  +  E  E E+EE +  KR
Sbjct: 180 AEENKKEDKEKEEEEEEKPKR 200



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 37/177 (20%), Positives = 67/177 (37%), Gaps = 23/177 (12%)

Query: 415 DWEQQRHQLERRKEELK---ERLAQVRKQISREE--HENRHMGNYRRIYPPEDKALLEKY 469
           D+E++R    +++EE++   ER+A  R     EE   E R      R+   +++  L + 
Sbjct: 3   DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62

Query: 470 ENLLAVAFQTFLSGRAASFQRELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPK 529
            + + V  Q  +                  +E        Q E DDE    +    R  +
Sbjct: 63  TDQVEVNAQNSVPD----------------EEAKTTTTNTQVEGDDEAAFLERLARREER 106

Query: 530 PLCSMPESTEIMKR--PKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQVTYNLK 584
               + E+ E  K   P    +  S  S    +++ ENE  E + K   +Q  Y ++
Sbjct: 107 RQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163


>gi|4826657 caldesmon 1 isoform 2 [Homo sapiens]
          Length = 538

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 47/201 (23%), Positives = 81/201 (40%), Gaps = 14/201 (6%)

Query: 384 DKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQISR 443
           ++RR L +QK E  R        +R+    +D +++    ERR+   +ERL Q +++ S 
Sbjct: 5   ERRRELRRQKREEMRL-----EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59

Query: 444 EEHENRHMGNYRRIYPPEDKALL---EKYENLLAVAFQTFLSGRAASFQRELNNPLKRMK 500
            +  ++   N +   P E+        + E     AF   L+ R    Q+ L   L+R K
Sbjct: 60  GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119

Query: 501 EEDILDLLEQCEIDDEKLMGKTTK---TRGPKPLCSMPESTEIMKR---PKYCSSDSSYD 554
           E D         +   ++   T +   T   +   S  E  EI +     K    +   D
Sbjct: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179

Query: 555 SSSSSSESDENEKEEYQNKKR 575
           +  +  E  E E+EE +  KR
Sbjct: 180 AEENKKEDKEKEEEEEEKPKR 200



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 37/177 (20%), Positives = 67/177 (37%), Gaps = 23/177 (12%)

Query: 415 DWEQQRHQLERRKEELK---ERLAQVRKQISREE--HENRHMGNYRRIYPPEDKALLEKY 469
           D+E++R    +++EE++   ER+A  R     EE   E R      R+   +++  L + 
Sbjct: 3   DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62

Query: 470 ENLLAVAFQTFLSGRAASFQRELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPK 529
            + + V  Q  +                  +E        Q E DDE    +    R  +
Sbjct: 63  TDQVEVNAQNSVPD----------------EEAKTTTTNTQVEGDDEAAFLERLARREER 106

Query: 530 PLCSMPESTEIMKR--PKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQVTYNLK 584
               + E+ E  K   P    +  S  S    +++ ENE  E + K   +Q  Y ++
Sbjct: 107 RQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 47/201 (23%), Positives = 81/201 (40%), Gaps = 14/201 (6%)

Query: 384 DKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQISR 443
           ++RR L +QK E  R        +R+    +D +++    ERR+   +ERL Q +++ S 
Sbjct: 5   ERRRELRRQKREEMRL-----EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59

Query: 444 EEHENRHMGNYRRIYPPEDKALL---EKYENLLAVAFQTFLSGRAASFQRELNNPLKRMK 500
            +  ++   N +   P E+        + E     AF   L+ R    Q+ L   L+R K
Sbjct: 60  GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119

Query: 501 EEDILDLLEQCEIDDEKLMGKTTK---TRGPKPLCSMPESTEIMKR---PKYCSSDSSYD 554
           E D         +   ++   T +   T   +   S  E  EI +     K    +   D
Sbjct: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179

Query: 555 SSSSSSESDENEKEEYQNKKR 575
           +  +  E  E E+EE +  KR
Sbjct: 180 AEENKKEDKEKEEEEEEKPKR 200



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 36/158 (22%), Positives = 65/158 (41%), Gaps = 22/158 (13%)

Query: 424 ERRKEELKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSG 483
           E+ +EE KER    R ++  EE E        RI   +DK + ++   + A         
Sbjct: 255 EKMEEEDKERAEAERARLEAEERE--------RIKAEQDKKIADERARIEA-------EE 299

Query: 484 RAASFQRELN--NPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPKPLCSMPESTEIM 541
           +AA+ +RE       +RM+EE+     E+  I +E+      + R         E     
Sbjct: 300 KAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR-----IKEEEKRAAE 354

Query: 542 KRPKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQV 579
           +R +    +         + ++E EK + + +KR KQ+
Sbjct: 355 ERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQL 392



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 37/177 (20%), Positives = 67/177 (37%), Gaps = 23/177 (12%)

Query: 415 DWEQQRHQLERRKEELK---ERLAQVRKQISREE--HENRHMGNYRRIYPPEDKALLEKY 469
           D+E++R    +++EE++   ER+A  R     EE   E R      R+   +++  L + 
Sbjct: 3   DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62

Query: 470 ENLLAVAFQTFLSGRAASFQRELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPK 529
            + + V  Q  +                  +E        Q E DDE    +    R  +
Sbjct: 63  TDQVEVNAQNSVPD----------------EEAKTTTTNTQVEGDDEAAFLERLARREER 106

Query: 530 PLCSMPESTEIMKR--PKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQVTYNLK 584
               + E+ E  K   P    +  S  S    +++ ENE  E + K   +Q  Y ++
Sbjct: 107 RQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 43/193 (22%), Positives = 83/193 (43%), Gaps = 25/193 (12%)

Query: 385 KRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQISRE 444
           KRR +A++ +  +R    Q   KR        E++R   E++KE+ +++  + R +  R+
Sbjct: 141 KRREMAREHSRRERDRLEQLERKR--------ERERKMREQQKEQREQKERERRAEERRK 192

Query: 445 EHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKRMKEEDI 504
           E E       RR      + + E Y + +  +  +    R    + EL +  K +KEE +
Sbjct: 193 ERE------ARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKM 246

Query: 505 --LDLLEQC-EIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDSSSSSSE 561
              DLL    +I D +    + ++   +      E  E          +   +  S+S E
Sbjct: 247 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE--------EEEEEEEEGSTSEE 298

Query: 562 SDENEKEEYQNKK 574
           S+E E+EE + ++
Sbjct: 299 SEEEEEEEEEEEE 311



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 45/207 (21%), Positives = 88/207 (42%), Gaps = 20/207 (9%)

Query: 385 KRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQR-HQLERRKE---ELKERLAQVRKQ 440
           +RR   +++ +  RR + +   + +    S  E+ R  QLER++E   +++E+  + R+Q
Sbjct: 121 ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 180

Query: 441 ISREEH--ENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKR 498
             RE    E R     RR      + + E Y + +  +  +    R    + EL +  K 
Sbjct: 181 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKP 240

Query: 499 MKEEDI--LDLLEQCE-IDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDS 555
           +KEE +   DLL   + I D +    + ++   +      E  E              + 
Sbjct: 241 VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE-----------EEEEE 289

Query: 556 SSSSSESDENEKEEYQNKKREKQVTYN 582
               S S+E+E+EE + ++ E++   N
Sbjct: 290 EEEGSTSEESEEEEEEEEEEEEETGSN 316


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 43/193 (22%), Positives = 83/193 (43%), Gaps = 25/193 (12%)

Query: 385 KRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQISRE 444
           KRR +A++ +  +R    Q   KR        E++R   E++KE+ +++  + R +  R+
Sbjct: 118 KRREMAREHSRRERDRLEQLERKR--------ERERKMREQQKEQREQKERERRAEERRK 169

Query: 445 EHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKRMKEEDI 504
           E E       RR      + + E Y + +  +  +    R    + EL +  K +KEE +
Sbjct: 170 ERE------ARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKM 223

Query: 505 --LDLLEQC-EIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDSSSSSSE 561
              DLL    +I D +    + ++   +      E  E          +   +  S+S E
Sbjct: 224 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE--------EEEEEEEEGSTSEE 275

Query: 562 SDENEKEEYQNKK 574
           S+E E+EE + ++
Sbjct: 276 SEEEEEEEEEEEE 288



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 45/207 (21%), Positives = 88/207 (42%), Gaps = 20/207 (9%)

Query: 385 KRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQR-HQLERRKE---ELKERLAQVRKQ 440
           +RR   +++ +  RR + +   + +    S  E+ R  QLER++E   +++E+  + R+Q
Sbjct: 98  ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 157

Query: 441 ISREEH--ENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKR 498
             RE    E R     RR      + + E Y + +  +  +    R    + EL +  K 
Sbjct: 158 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKP 217

Query: 499 MKEEDI--LDLLEQCE-IDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDS 555
           +KEE +   DLL   + I D +    + ++   +      E  E              + 
Sbjct: 218 VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE-----------EEEEE 266

Query: 556 SSSSSESDENEKEEYQNKKREKQVTYN 582
               S S+E+E+EE + ++ E++   N
Sbjct: 267 EEEGSTSEESEEEEEEEEEEEEETGSN 293


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 43/193 (22%), Positives = 83/193 (43%), Gaps = 25/193 (12%)

Query: 385 KRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQISRE 444
           KRR +A++ +  +R    Q   KR        E++R   E++KE+ +++  + R +  R+
Sbjct: 107 KRREMAREHSRRERDRLEQLERKR--------ERERKMREQQKEQREQKERERRAEERRK 158

Query: 445 EHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKRMKEEDI 504
           E E       RR      + + E Y + +  +  +    R    + EL +  K +KEE +
Sbjct: 159 ERE------ARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKM 212

Query: 505 --LDLLEQC-EIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDSSSSSSE 561
              DLL    +I D +    + ++   +      E  E          +   +  S+S E
Sbjct: 213 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE--------EEEEEEEEGSTSEE 264

Query: 562 SDENEKEEYQNKK 574
           S+E E+EE + ++
Sbjct: 265 SEEEEEEEEEEEE 277



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 45/207 (21%), Positives = 88/207 (42%), Gaps = 20/207 (9%)

Query: 385 KRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQR-HQLERRKE---ELKERLAQVRKQ 440
           +RR   +++ +  RR + +   + +    S  E+ R  QLER++E   +++E+  + R+Q
Sbjct: 87  ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 146

Query: 441 ISREEH--ENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKR 498
             RE    E R     RR      + + E Y + +  +  +    R    + EL +  K 
Sbjct: 147 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKP 206

Query: 499 MKEEDI--LDLLEQCE-IDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDS 555
           +KEE +   DLL   + I D +    + ++   +      E  E              + 
Sbjct: 207 VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE-----------EEEEE 255

Query: 556 SSSSSESDENEKEEYQNKKREKQVTYN 582
               S S+E+E+EE + ++ E++   N
Sbjct: 256 EEEGSTSEESEEEEEEEEEEEEETGSN 282


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,135,771
Number of Sequences: 37866
Number of extensions: 1601522
Number of successful extensions: 10035
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 92
Number of HSP's successfully gapped in prelim test: 349
Number of HSP's that attempted gapping in prelim test: 8218
Number of HSP's gapped (non-prelim): 1562
length of query: 887
length of database: 18,247,518
effective HSP length: 111
effective length of query: 776
effective length of database: 14,044,392
effective search space: 10898448192
effective search space used: 10898448192
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.