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Search of human proteins with 89941470
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|89941470 ankyrin repeat domain 34 [Homo sapiens]
(496 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|89941470 ankyrin repeat domain 34 [Homo sapiens] 1014 0.0
gi|226437606 ankyrin repeat domain 34C [Homo sapiens] 344 9e-95
gi|239756364 PREDICTED: ankyrin repeat domain 34C [Homo sapiens] 344 9e-95
gi|239750889 PREDICTED: ankyrin repeat domain 34C [Homo sapiens] 344 9e-95
gi|239745252 PREDICTED: ankyrin repeat domain 34C [Homo sapiens] 344 9e-95
gi|52138747 ankyrin repeat domain 34B [Homo sapiens] 266 3e-71
gi|169208819 PREDICTED: similar to kinase D-interacting substrat... 74 2e-13
gi|169208593 PREDICTED: similar to kinase D-interacting substrat... 74 2e-13
gi|169208169 PREDICTED: similar to kinase D-interacting substrat... 74 2e-13
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 70 3e-12
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 68 2e-11
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 67 4e-11
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 67 4e-11
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 66 8e-11
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 64 3e-10
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 64 3e-10
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 64 3e-10
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 64 3e-10
gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo sap... 64 3e-10
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 63 5e-10
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo... 63 7e-10
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ... 63 7e-10
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 63 7e-10
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 62 9e-10
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 62 9e-10
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 62 9e-10
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 61 2e-09
gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain ... 60 3e-09
gi|7657265 fem-1 homolog b [Homo sapiens] 60 3e-09
gi|163965366 nascent polypeptide-associated complex alpha subuni... 58 2e-08
>gi|89941470 ankyrin repeat domain 34 [Homo sapiens]
Length = 496
Score = 1014 bits (2621), Expect = 0.0
Identities = 496/496 (100%), Positives = 496/496 (100%)
Query: 1 MLHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMV 60
MLHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMV
Sbjct: 1 MLHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMV 60
Query: 61 RYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALD 120
RYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALD
Sbjct: 61 RYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALD 120
Query: 121 RGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGF 180
RGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGF
Sbjct: 121 RGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGF 180
Query: 181 CTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPK 240
CTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPK
Sbjct: 181 CTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPK 240
Query: 241 PLKRLNSEPWGLVAPPQPVPPTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPP 300
PLKRLNSEPWGLVAPPQPVPPTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPP
Sbjct: 241 PLKRLNSEPWGLVAPPQPVPPTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPP 300
Query: 301 WAEKVTSGGPLSRRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLE 360
WAEKVTSGGPLSRRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLE
Sbjct: 301 WAEKVTSGGPLSRRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLE 360
Query: 361 RRRYSASPLTLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQT 420
RRRYSASPLTLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQT
Sbjct: 361 RRRYSASPLTLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQT 420
Query: 421 RPGFLPPLNVSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTEQIR 480
RPGFLPPLNVSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTEQIR
Sbjct: 421 RPGFLPPLNVSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTEQIR 480
Query: 481 LLGGFQSLGGPGEPGR 496
LLGGFQSLGGPGEPGR
Sbjct: 481 LLGGFQSLGGPGEPGR 496
>gi|226437606 ankyrin repeat domain 34C [Homo sapiens]
Length = 535
Score = 344 bits (883), Expect = 9e-95
Identities = 233/547 (42%), Positives = 305/547 (55%), Gaps = 81/547 (14%)
Query: 2 LHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQN--KARM 59
L T+G++LL+AV G+LRL RLLLEGGAY+NE + +GETALM AC ++ D Q+ K++M
Sbjct: 8 LRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKM 67
Query: 60 VRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHAL 119
V+YLL+ ADPNI D+ G+TAL+HAC G V SLLL +GADPS+ D GASALV+A+
Sbjct: 68 VKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAI 127
Query: 120 DRGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPG 179
+ D++ L LLDACKAKG EVIIITTD S SGTK T+QYLN PPSP VED SP
Sbjct: 128 NADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVED----RHSPP 183
Query: 180 FCTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLPKPP---------DDPSPSEP 230
C SPS+I+L+ G+ SP ++E+ D F P + SP+
Sbjct: 184 LCASPSDIELKAL-----GLDSPLTEKED---DFFSLQAGHPSSCNTSKAVNEPGSPTRK 235
Query: 231 LPKPPRHPPKPLKRLNSEPWGLVAP-----PQPVPPTEGRPGIERLTAEFNGLTLTGRPR 285
+ R LKRL SEPWGL+AP T G + + ++ R
Sbjct: 236 VSNLKRARLPQLKRLQSEPWGLIAPSVLAASTRQDETHGASTDNEVIKSISDISFPKRGP 295
Query: 286 LSRRHSTEGPED------------------PPPWAEKVTSGGP----LSRRNTAPEAQES 323
LSR +S + + P W G L+RR T P QE
Sbjct: 296 LSRTNSIDSKDPTLFHTVTEQVLKIPVSSAPASWKAAYEKGQAPHPRLARRGTLPVDQEK 355
Query: 324 ---GP--PSGLRQKLS----RMEPVELD-TPGHLCPDSP-----ESSRLSLERRRYSASP 368
GP PS L++ S + +LD PG PD P ES + L+R++ ++S
Sbjct: 356 CGMGPSGPSALKEPASLKWLENDLYDLDIQPG---PDPPNSISLESGKGPLDRKKLNSSH 412
Query: 369 LTLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPL 428
L+L R+S +++P + SP S RRR P LLERRGSGTLLLD IS TRPGFLPPL
Sbjct: 413 LSL-----FHGSRESLDTVP-STSPSSARRRPPHLLERRGSGTLLLDRISHTRPGFLPPL 466
Query: 429 NVSPHPPIPDIRPQ-------PGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTEQIRL 481
NV+ +PPIPDIR G +P P + R+K+KL+RRHSMQ EQ++
Sbjct: 467 NVNLNPPIPDIRSSSKPSCSLASGLKSMVPVAPSSPKRVDLRSKKKLLRRHSMQIEQMKQ 526
Query: 482 LGGFQSL 488
L F+ +
Sbjct: 527 LSDFEEI 533
>gi|239756364 PREDICTED: ankyrin repeat domain 34C [Homo sapiens]
Length = 534
Score = 344 bits (883), Expect = 9e-95
Identities = 233/547 (42%), Positives = 305/547 (55%), Gaps = 81/547 (14%)
Query: 2 LHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQN--KARM 59
L T+G++LL+AV G+LRL RLLLEGGAY+NE + +GETALM AC ++ D Q+ K++M
Sbjct: 7 LRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKM 66
Query: 60 VRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHAL 119
V+YLL+ ADPNI D+ G+TAL+HAC G V SLLL +GADPS+ D GASALV+A+
Sbjct: 67 VKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAI 126
Query: 120 DRGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPG 179
+ D++ L LLDACKAKG EVIIITTD S SGTK T+QYLN PPSP VED SP
Sbjct: 127 NADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVED----RHSPP 182
Query: 180 FCTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLPKPP---------DDPSPSEP 230
C SPS+I+L+ G+ SP ++E+ D F P + SP+
Sbjct: 183 LCASPSDIELKAL-----GLDSPLTEKED---DFFSLQAGHPSSCNTSKAVNEPGSPTRK 234
Query: 231 LPKPPRHPPKPLKRLNSEPWGLVAP-----PQPVPPTEGRPGIERLTAEFNGLTLTGRPR 285
+ R LKRL SEPWGL+AP T G + + ++ R
Sbjct: 235 VSNLKRARLPQLKRLQSEPWGLIAPSVLAASTRQDETHGASTDNEVIKSISDISFPKRGP 294
Query: 286 LSRRHSTEGPED------------------PPPWAEKVTSGGP----LSRRNTAPEAQES 323
LSR +S + + P W G L+RR T P QE
Sbjct: 295 LSRTNSIDSKDPTLFHTVTEQVLKIPVSSAPASWKAAYEKGQAPHPRLARRGTLPVDQEK 354
Query: 324 ---GP--PSGLRQKLS----RMEPVELD-TPGHLCPDSP-----ESSRLSLERRRYSASP 368
GP PS L++ S + +LD PG PD P ES + L+R++ ++S
Sbjct: 355 CGMGPSGPSALKEPASLKWLENDLYDLDIQPG---PDPPNSISLESGKGPLDRKKLNSSH 411
Query: 369 LTLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPL 428
L+L R+S +++P + SP S RRR P LLERRGSGTLLLD IS TRPGFLPPL
Sbjct: 412 LSL-----FHGSRESLDTVP-STSPSSARRRPPHLLERRGSGTLLLDRISHTRPGFLPPL 465
Query: 429 NVSPHPPIPDIRPQ-------PGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTEQIRL 481
NV+ +PPIPDIR G +P P + R+K+KL+RRHSMQ EQ++
Sbjct: 466 NVNLNPPIPDIRSSSKPSCSLASGLKSMVPVAPSSPKRVDLRSKKKLLRRHSMQIEQMKQ 525
Query: 482 LGGFQSL 488
L F+ +
Sbjct: 526 LSDFEEI 532
>gi|239750889 PREDICTED: ankyrin repeat domain 34C [Homo sapiens]
Length = 534
Score = 344 bits (883), Expect = 9e-95
Identities = 233/547 (42%), Positives = 305/547 (55%), Gaps = 81/547 (14%)
Query: 2 LHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQN--KARM 59
L T+G++LL+AV G+LRL RLLLEGGAY+NE + +GETALM AC ++ D Q+ K++M
Sbjct: 7 LRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKM 66
Query: 60 VRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHAL 119
V+YLL+ ADPNI D+ G+TAL+HAC G V SLLL +GADPS+ D GASALV+A+
Sbjct: 67 VKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAI 126
Query: 120 DRGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPG 179
+ D++ L LLDACKAKG EVIIITTD S SGTK T+QYLN PPSP VED SP
Sbjct: 127 NADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVED----RHSPP 182
Query: 180 FCTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLPKPP---------DDPSPSEP 230
C SPS+I+L+ G+ SP ++E+ D F P + SP+
Sbjct: 183 LCASPSDIELKAL-----GLDSPLTEKED---DFFSLQAGHPSSCNTSKAVNEPGSPTRK 234
Query: 231 LPKPPRHPPKPLKRLNSEPWGLVAP-----PQPVPPTEGRPGIERLTAEFNGLTLTGRPR 285
+ R LKRL SEPWGL+AP T G + + ++ R
Sbjct: 235 VSNLKRARLPQLKRLQSEPWGLIAPSVLAASTRQDETHGASTDNEVIKSISDISFPKRGP 294
Query: 286 LSRRHSTEGPED------------------PPPWAEKVTSGGP----LSRRNTAPEAQES 323
LSR +S + + P W G L+RR T P QE
Sbjct: 295 LSRTNSIDSKDPTLFHTVTEQVLKIPVSSAPASWKAAYEKGQAPHPRLARRGTLPVDQEK 354
Query: 324 ---GP--PSGLRQKLS----RMEPVELD-TPGHLCPDSP-----ESSRLSLERRRYSASP 368
GP PS L++ S + +LD PG PD P ES + L+R++ ++S
Sbjct: 355 CGMGPSGPSALKEPASLKWLENDLYDLDIQPG---PDPPNSISLESGKGPLDRKKLNSSH 411
Query: 369 LTLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPL 428
L+L R+S +++P + SP S RRR P LLERRGSGTLLLD IS TRPGFLPPL
Sbjct: 412 LSL-----FHGSRESLDTVP-STSPSSARRRPPHLLERRGSGTLLLDRISHTRPGFLPPL 465
Query: 429 NVSPHPPIPDIRPQ-------PGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTEQIRL 481
NV+ +PPIPDIR G +P P + R+K+KL+RRHSMQ EQ++
Sbjct: 466 NVNLNPPIPDIRSSSKPSCSLASGLKSMVPVAPSSPKRVDLRSKKKLLRRHSMQIEQMKQ 525
Query: 482 LGGFQSL 488
L F+ +
Sbjct: 526 LSDFEEI 532
>gi|239745252 PREDICTED: ankyrin repeat domain 34C [Homo sapiens]
Length = 535
Score = 344 bits (883), Expect = 9e-95
Identities = 233/547 (42%), Positives = 305/547 (55%), Gaps = 81/547 (14%)
Query: 2 LHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQN--KARM 59
L T+G++LL+AV G+LRL RLLLEGGAY+NE + +GETALM AC ++ D Q+ K++M
Sbjct: 8 LRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKM 67
Query: 60 VRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHAL 119
V+YLL+ ADPNI D+ G+TAL+HAC G V SLLL +GADPS+ D GASALV+A+
Sbjct: 68 VKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAI 127
Query: 120 DRGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPG 179
+ D++ L LLDACKAKG EVIIITTD S SGTK T+QYLN PPSP VED SP
Sbjct: 128 NADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVED----RHSPP 183
Query: 180 FCTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLPKPP---------DDPSPSEP 230
C SPS+I+L+ G+ SP ++E+ D F P + SP+
Sbjct: 184 LCASPSDIELKAL-----GLDSPLTEKED---DFFSLQAGHPSSCNTSKAVNEPGSPTRK 235
Query: 231 LPKPPRHPPKPLKRLNSEPWGLVAP-----PQPVPPTEGRPGIERLTAEFNGLTLTGRPR 285
+ R LKRL SEPWGL+AP T G + + ++ R
Sbjct: 236 VSNLKRARLPQLKRLQSEPWGLIAPSVLAASTRQDETHGASTDNEVIKSISDISFPKRGP 295
Query: 286 LSRRHSTEGPED------------------PPPWAEKVTSGGP----LSRRNTAPEAQES 323
LSR +S + + P W G L+RR T P QE
Sbjct: 296 LSRTNSIDSKDPTLFHTVTEQVLKIPVSSAPASWKAAYEKGQAPHPRLARRGTLPVDQEK 355
Query: 324 ---GP--PSGLRQKLS----RMEPVELD-TPGHLCPDSP-----ESSRLSLERRRYSASP 368
GP PS L++ S + +LD PG PD P ES + L+R++ ++S
Sbjct: 356 CGMGPSGPSALKEPASLKWLENDLYDLDIQPG---PDPPNSISLESGKGPLDRKKLNSSH 412
Query: 369 LTLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPL 428
L+L R+S +++P + SP S RRR P LLERRGSGTLLLD IS TRPGFLPPL
Sbjct: 413 LSL-----FHGSRESLDTVP-STSPSSARRRPPHLLERRGSGTLLLDRISHTRPGFLPPL 466
Query: 429 NVSPHPPIPDIRPQ-------PGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTEQIRL 481
NV+ +PPIPDIR G +P P + R+K+KL+RRHSMQ EQ++
Sbjct: 467 NVNLNPPIPDIRSSSKPSCSLASGLKSMVPVAPSSPKRVDLRSKKKLLRRHSMQIEQMKQ 526
Query: 482 LGGFQSL 488
L F+ +
Sbjct: 527 LSDFEEI 533
>gi|52138747 ankyrin repeat domain 34B [Homo sapiens]
Length = 514
Score = 266 bits (680), Expect = 3e-71
Identities = 205/541 (37%), Positives = 273/541 (50%), Gaps = 90/541 (16%)
Query: 2 LHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQN--KARM 59
+ +EG++L++AV Q +LRL RLLLEGGAY+NE + +GET LM AC+ ++ D Q+ KA+M
Sbjct: 7 ISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKM 66
Query: 60 VRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHAL 119
V+YLLE ADPNI D+ G+TALMHAC G V SLLL GAD S++DH+ SALV+A+
Sbjct: 67 VKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAI 126
Query: 120 DRGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPG 179
+ D ETL LL ACKAKG EVIIITT SP G T+QYLN PP SP
Sbjct: 127 NSEDTETLKVLLSACKAKGKEVIIITTAKSPCGKHTTKQYLNMPPV-----DIDGCHSPA 181
Query: 180 FCTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEF---PLPKPPDDP-SPSEPLPKPP 235
CT+PSEI ++TA SP + E + +F F L DD P P+ KP
Sbjct: 182 TCTTPSEIDIKTAS-------SPLSHSSETELTLFGFKDLELAGSNDDTWDPGSPVRKPA 234
Query: 236 RHPPKPLKRLNSEPWGLVAPP---------------QPVPPTEGRPGIERLTAEFNGLTL 280
P P K ++ PW + +PP Q + P E L+ + NGL L
Sbjct: 235 LAPKGP-KLPHAPPW-VKSPPLLMHQNRVASLQEELQDITPE------EELSYKTNGLAL 286
Query: 281 TGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPSGLRQKLSRMEPVE 340
+ R RH + +D + L + A + S + LS
Sbjct: 287 S--KRFITRHQSIDVKD---------TAHLLRAFDQASSRKMSYDEINCQSYLSEGNQQC 335
Query: 341 LDTPGHLCPDSPES----------SRLSLERRRYSA----SPLTLPPAGS---------- 376
++ P PDS ++ + +L YS+ S PP
Sbjct: 336 IEVPVDQDPDSNQTIFASTLRSIVQKRNLGANHYSSDSQLSAGLTPPTSEDGKALIGKKK 395
Query: 377 --APSPRQSQES--LPGAVSPLSGRRRSPGLLERRGSGTLLLDH-ISQTRPGFLPPLNVS 431
+PSP Q ES L + P RR+ +LE RGSG LDH ++QTR GFLPPLNV+
Sbjct: 396 ILSPSPSQLSESKELLENIPPGPLSRRNHAVLEGRGSGAFPLDHSVTQTRQGFLPPLNVN 455
Query: 432 PHPPIPDIRPQ-------PGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTEQIRLLGG 484
HPPI DI G+ +P P P ++K+ L+RR S+QTEQI+ L
Sbjct: 456 SHPPISDINVNNKICSLLSCGQKVLMPTVPI--FPKEFKSKKMLLRRQSLQTEQIKQLVN 513
Query: 485 F 485
F
Sbjct: 514 F 514
>gi|169208819 PREDICTED: similar to kinase D-interacting substrate
220 [Homo sapiens]
Length = 380
Score = 74.3 bits (181), Expect = 2e-13
Identities = 75/220 (34%), Positives = 94/220 (42%), Gaps = 36/220 (16%)
Query: 10 LRAVGQGKLRLARLLLEG--GAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
L A+ GK+ LAR +L+ + ++ QG T LM A DP +AR VR LLEQG
Sbjct: 17 LEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVA--VGLPDPALRARFVRLLLEQG 74
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHA--------- 118
A N+ D GRTAL AC G AV LL+ DP D AG S ++ A
Sbjct: 75 AAVNLRDERGRTALSLACERGHLDAV-QLLVQFSGDPEAADSAGNSPVMWAAACGHGAVL 133
Query: 119 -------------LDRGDRETLATL-LDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPP 164
LDR +R L L L A + GT V +T + + NS
Sbjct: 134 EFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSDS 193
Query: 165 SPGVEDPAPAS------PSPGFCTSPSEIQLQTAGGGGRG 198
PG PAPA+ PSP P + A GG G
Sbjct: 194 PPG--RPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGG 231
>gi|169208593 PREDICTED: similar to kinase D-interacting substrate
220 [Homo sapiens]
Length = 380
Score = 74.3 bits (181), Expect = 2e-13
Identities = 75/220 (34%), Positives = 94/220 (42%), Gaps = 36/220 (16%)
Query: 10 LRAVGQGKLRLARLLLEG--GAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
L A+ GK+ LAR +L+ + ++ QG T LM A DP +AR VR LLEQG
Sbjct: 17 LEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVA--VGLPDPALRARFVRLLLEQG 74
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHA--------- 118
A N+ D GRTAL AC G AV LL+ DP D AG S ++ A
Sbjct: 75 AAVNLRDERGRTALSLACERGHLDAV-QLLVQFSGDPEAADSAGNSPVMWAAACGHGAVL 133
Query: 119 -------------LDRGDRETLATL-LDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPP 164
LDR +R L L L A + GT V +T + + NS
Sbjct: 134 EFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSDS 193
Query: 165 SPGVEDPAPAS------PSPGFCTSPSEIQLQTAGGGGRG 198
PG PAPA+ PSP P + A GG G
Sbjct: 194 PPG--RPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGG 231
>gi|169208169 PREDICTED: similar to kinase D-interacting substrate
220 [Homo sapiens]
Length = 380
Score = 74.3 bits (181), Expect = 2e-13
Identities = 75/220 (34%), Positives = 94/220 (42%), Gaps = 36/220 (16%)
Query: 10 LRAVGQGKLRLARLLLEG--GAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
L A+ GK+ LAR +L+ + ++ QG T LM A DP +AR VR LLEQG
Sbjct: 17 LEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVA--VGLPDPALRARFVRLLLEQG 74
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHA--------- 118
A N+ D GRTAL AC G AV LL+ DP D AG S ++ A
Sbjct: 75 AAVNLRDERGRTALSLACERGHLDAV-QLLVQFSGDPEAADSAGNSPVMWAAACGHGAVL 133
Query: 119 -------------LDRGDRETLATL-LDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPP 164
LDR +R L L L A + GT V +T + + NS
Sbjct: 134 EFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSDS 193
Query: 165 SPGVEDPAPAS------PSPGFCTSPSEIQLQTAGGGGRG 198
PG PAPA+ PSP P + A GG G
Sbjct: 194 PPG--RPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGG 231
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 70.5 bits (171), Expect = 3e-12
Identities = 49/125 (39%), Positives = 66/125 (52%), Gaps = 7/125 (5%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A G+GKL + RLLLE GA V + + +G L + R Q ++V LL G
Sbjct: 1037 ALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVR------QGHWQIVDLLLTHG 1090
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETL 127
AD N+AD+ GRT LM A A G LLA GA ++ D G +AL A +G +
Sbjct: 1091 ADVNMADKQGRTPLMMA-ASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVV 1149
Query: 128 ATLLD 132
+L+D
Sbjct: 1150 RSLVD 1154
Score = 48.1 bits (113), Expect = 2e-05
Identities = 41/123 (33%), Positives = 57/123 (46%), Gaps = 7/123 (5%)
Query: 9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQGA 68
L+ A +G L LL GA + D +G TAL AC + +VR L++ GA
Sbjct: 1104 LMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACL------KGHLSVVRSLVDNGA 1157
Query: 69 DPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLA 128
+ AD+ GRT L A G A V L+ HGA D++G L A+ + +
Sbjct: 1158 ATDHADKNGRTPL-DLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVV 1216
Query: 129 TLL 131
TLL
Sbjct: 1217 TLL 1219
Score = 41.2 bits (95), Expect = 0.002
Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 5/124 (4%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
A LR + ++++RLL+ GGA +N A + ++ MV LLE G
Sbjct: 853 ASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHL----GYTEMVALLLEFG 908
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETL 127
A+ + + G T L +A A G ++ LL A D G ALVHA RG E +
Sbjct: 909 ANVDASSESGLTPLGYA-AAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVV 967
Query: 128 ATLL 131
L+
Sbjct: 968 KFLI 971
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 67.8 bits (164), Expect = 2e-11
Identities = 51/126 (40%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETAL-MAACRARYDDPQNKARMVRYLLEQ 66
ALL A G+ R LL GA V+ D G TAL +AA R D + LL
Sbjct: 206 ALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQD-------IEVLLGH 258
Query: 67 GADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRET 126
GADP I DR GR+AL H A G LL+ GA+ RD G + L HA G E
Sbjct: 259 GADPGIRDRHGRSAL-HRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEV 317
Query: 127 LATLLD 132
LLD
Sbjct: 318 AGCLLD 323
Score = 63.5 bits (153), Expect = 4e-10
Identities = 52/128 (40%), Positives = 62/128 (48%), Gaps = 8/128 (6%)
Query: 6 GHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLE 65
GH LL+AV +G L LL GA V E D G T L A + A +VR LL+
Sbjct: 43 GH-LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVL------RGHAPLVRLLLQ 95
Query: 66 QGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRE 125
+GA DR GRTAL H A G + VA LLL GA + R G + L A G
Sbjct: 96 RGAPVGAVDRAGRTAL-HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTL 154
Query: 126 TLATLLDA 133
A LL+A
Sbjct: 155 LAARLLEA 162
Score = 53.1 bits (126), Expect = 6e-07
Identities = 41/111 (36%), Positives = 54/111 (48%), Gaps = 14/111 (12%)
Query: 12 AVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQGADPN 71
A G+L + LL GGA + + AL+ A A + +R+LL +GA +
Sbjct: 184 AAAGGRLAVLELLAAGGAGL-------DGALLVAAAA------GRGAALRFLLARGARVD 230
Query: 72 IADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRG 122
D G TAL A A G + +LL HGADP +RD G SAL A RG
Sbjct: 231 ARDGAGATALGLAAALGRSQDI-EVLLGHGADPGIRDRHGRSALHRAAARG 280
Score = 43.1 bits (100), Expect = 6e-04
Identities = 34/100 (34%), Positives = 47/100 (47%), Gaps = 7/100 (7%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL RA +G L +LL+ GA V+ D G T L A R + + LL++G
Sbjct: 272 ALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASR------EGHVEVAGCLLDRG 325
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVR 107
A + L +T L H A G LLL+ GA P++R
Sbjct: 326 AQVDATGWLRKTPL-HLAAERGHGPTVGLLLSRGASPTLR 364
Score = 35.4 bits (80), Expect = 0.12
Identities = 42/124 (33%), Positives = 53/124 (42%), Gaps = 18/124 (14%)
Query: 12 AVGQGKLRLARLLLE----GGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
A G LA LLE G A DA+G TA A + + ++ L G
Sbjct: 147 AAALGHTLLAARLLEAPGPGPAAAEAEDARGWTA------AHWAAAGGRLAVLELLAAGG 200
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETL 127
A + AL+ A A G GAA+ LLA GA RD AGA+AL A G + +
Sbjct: 201 AGLD-------GALLVAAAAGRGAALR-FLLARGARVDARDGAGATALGLAAALGRSQDI 252
Query: 128 ATLL 131
LL
Sbjct: 253 EVLL 256
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 67.0 bits (162), Expect = 4e-11
Identities = 49/125 (39%), Positives = 66/125 (52%), Gaps = 7/125 (5%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A G+GKL + LLL GA V+ + +G L A R Q ++VR LLE+G
Sbjct: 1074 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAAR------QGHWQIVRLLLERG 1127
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETL 127
D N++D+ GRT LM A A G + LL+ GA S D G SAL A +G R +
Sbjct: 1128 CDVNLSDKQGRTPLMVA-ACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVV 1186
Query: 128 ATLLD 132
L++
Sbjct: 1187 QYLVE 1191
Score = 57.0 bits (136), Expect = 4e-08
Identities = 47/125 (37%), Positives = 59/125 (47%), Gaps = 9/125 (7%)
Query: 9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALM-AACRARYDDPQNKARMVRYLLEQG 67
L A QG ++ RLLLE G VN D QG T LM AAC V +LL +G
Sbjct: 1108 LFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLST-------VEFLLSKG 1160
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETL 127
A + D+ G +AL AC G AV L+ GA D G + L A GD ET+
Sbjct: 1161 AALSSLDKEGLSALSWACLKGH-RAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETV 1219
Query: 128 ATLLD 132
L++
Sbjct: 1220 LYLVE 1224
Score = 39.7 bits (91), Expect = 0.006
Identities = 40/124 (32%), Positives = 55/124 (44%), Gaps = 5/124 (4%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
A LR + ++++RLL+ GGA VN A + ++ + +V LLE G
Sbjct: 895 ASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEE----VVTLLLEFG 950
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETL 127
A + G TAL +A A G V LL G D G ALVH+ RG + L
Sbjct: 951 ACLDGTSENGMTALCYAAAAGHMKLVC-LLTKKGVRVDHLDKKGQCALVHSALRGHGDIL 1009
Query: 128 ATLL 131
LL
Sbjct: 1010 QYLL 1013
Score = 33.1 bits (74), Expect = 0.60
Identities = 41/163 (25%), Positives = 60/163 (36%), Gaps = 38/163 (23%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDD--------------P 53
AL A G ++L LL + G V+ D +G+ AL+ + + D P
Sbjct: 963 ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022
Query: 54 Q--------------------NKARMVRYLL----EQGADPNIADRLGRTALMHACAGGG 89
Q + +V+ LL E + N D L + A AG G
Sbjct: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
Query: 90 GAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLD 132
V LLL HGA S + G L A +G + + LL+
Sbjct: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLE 1125
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 67.0 bits (162), Expect = 4e-11
Identities = 49/125 (39%), Positives = 66/125 (52%), Gaps = 7/125 (5%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A G+GKL + LLL GA V+ + +G L A R Q ++VR LLE+G
Sbjct: 1082 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAAR------QGHWQIVRLLLERG 1135
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETL 127
D N++D+ GRT LM A A G + LL+ GA S D G SAL A +G R +
Sbjct: 1136 CDVNLSDKQGRTPLMVA-ACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVV 1194
Query: 128 ATLLD 132
L++
Sbjct: 1195 QYLVE 1199
Score = 57.0 bits (136), Expect = 4e-08
Identities = 47/125 (37%), Positives = 59/125 (47%), Gaps = 9/125 (7%)
Query: 9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALM-AACRARYDDPQNKARMVRYLLEQG 67
L A QG ++ RLLLE G VN D QG T LM AAC V +LL +G
Sbjct: 1116 LFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLST-------VEFLLSKG 1168
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETL 127
A + D+ G +AL AC G AV L+ GA D G + L A GD ET+
Sbjct: 1169 AALSSLDKEGLSALSWACLKGH-RAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETV 1227
Query: 128 ATLLD 132
L++
Sbjct: 1228 LYLVE 1232
Score = 39.7 bits (91), Expect = 0.006
Identities = 40/124 (32%), Positives = 55/124 (44%), Gaps = 5/124 (4%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
A LR + ++++RLL+ GGA VN A + ++ + +V LLE G
Sbjct: 903 ASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEE----VVTLLLEFG 958
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETL 127
A + G TAL +A A G V LL G D G ALVH+ RG + L
Sbjct: 959 ACLDGTSENGMTALCYAAAAGHMKLVC-LLTKKGVRVDHLDKKGQCALVHSALRGHGDIL 1017
Query: 128 ATLL 131
LL
Sbjct: 1018 QYLL 1021
Score = 33.1 bits (74), Expect = 0.60
Identities = 41/163 (25%), Positives = 60/163 (36%), Gaps = 38/163 (23%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDD--------------P 53
AL A G ++L LL + G V+ D +G+ AL+ + + D P
Sbjct: 971 ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030
Query: 54 Q--------------------NKARMVRYLL----EQGADPNIADRLGRTALMHACAGGG 89
Q + +V+ LL E + N D L + A AG G
Sbjct: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
Query: 90 GAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLD 132
V LLL HGA S + G L A +G + + LL+
Sbjct: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLE 1133
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 65.9 bits (159), Expect = 8e-11
Identities = 54/179 (30%), Positives = 75/179 (41%), Gaps = 10/179 (5%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A G L + +L A++N D G T L+ A + + D + R LL+QG
Sbjct: 151 ALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTD------LCRLLLQQG 204
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETL 127
A N D GRTALM AC G V +LL GA P + D G A + GD+ L
Sbjct: 205 AAANDQDLQGRTALMLACEGASPETV-EVLLQGGAQPGITDALGQDAAHYGALAGDKLIL 263
Query: 128 ATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSE 186
L +A + + D SG ++ ++S G A P P P +
Sbjct: 264 HLLQEAAQRPSPPSALTEDD---SGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDD 319
Score = 39.7 bits (91), Expect = 0.006
Identities = 32/107 (29%), Positives = 52/107 (48%), Gaps = 7/107 (6%)
Query: 12 AVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQGADPN 71
A +G +++ G+ V D G AL A A+Y PQ ++ LL+ +
Sbjct: 89 AAMRGAASCLEVMIAHGSNVMSADGAGYNALHLA--AKYGHPQ----CLKQLLQASCVVD 142
Query: 72 IADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHA 118
+ D G TAL HA A GG + + +L + A + +D +GA+ L+ A
Sbjct: 143 VVDSSGWTALHHA-AAGGCLSCSEVLCSFKAHLNPQDRSGATPLIIA 188
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 63.9 bits (154), Expect = 3e-10
Identities = 70/329 (21%), Positives = 115/329 (34%), Gaps = 34/329 (10%)
Query: 147 DTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQE 206
+ +P+ TK P ++PAP +P T+ E T +P +
Sbjct: 246 EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS------APTTPK 299
Query: 207 EEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRP 266
E P P P P+P+ P P P +P EP P P P E P
Sbjct: 300 E---------PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP 350
Query: 267 GIERLTAEFN------GLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEA 320
+ A P ++ S P++P P T P + + AP
Sbjct: 351 TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP---TTTKSAPTTTKEPAPTT 407
Query: 321 QESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGS---A 377
+S P + + + TP P +P+ + + +P P + A
Sbjct: 408 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 467
Query: 378 P-SPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPI 436
P +P++ + P +P + ++ +P E+ T + + T P L P +P P
Sbjct: 468 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT--PEKPAPTTPEELAP--TTPEEPT 523
Query: 437 PDIRPQPGGRAPSLPAP--PYAGAPGSPR 463
P +P P AP P AP +P+
Sbjct: 524 PTTPEEPAPTTPKAAAPNTPKEPAPTTPK 552
Score = 61.6 bits (148), Expect = 2e-09
Identities = 70/324 (21%), Positives = 114/324 (35%), Gaps = 51/324 (15%)
Query: 145 TTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRA 204
T + +P+ TK P + PAP +P T+P E P
Sbjct: 283 TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE---------------PTP 327
Query: 205 QEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVA-PPQPVPPTE 263
+E + P P P +P+P+ P P P +P EP P P P E
Sbjct: 328 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKE 387
Query: 264 GRPGIERLTAEFNGLTLTGRPR-LSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQE 322
P T + T T P + + + P++P P K P + + AP +
Sbjct: 388 PAP-----TTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK--EPAPTTPKEPAPTTPK 440
Query: 323 SGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGSAP-SPR 381
P+ TP P +P+ + ++ P P AP +P+
Sbjct: 441 KPAPT---------------TPKEPAPTTPKEPAPTTTKK-----PAPTTPKEPAPTTPK 480
Query: 382 QSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRP 441
++ + P ++P + + +P E+ T + ++ T P P +P P P
Sbjct: 481 ETAPTTPKKLTPTTPEKLAPTTPEKPAPTT--PEELAPTTPE--EPTPTTPEEPAPTTPK 536
Query: 442 QPGGRAPSLPAP--PYAGAPGSPR 463
P PAP P AP +P+
Sbjct: 537 AAAPNTPKEPAPTTPKEPAPTTPK 560
Score = 57.0 bits (136), Expect = 4e-08
Identities = 74/353 (20%), Positives = 117/353 (33%), Gaps = 31/353 (8%)
Query: 145 TTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRA 204
T + +P+ TK P ++PAP +P T+P + T A
Sbjct: 400 TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 459
Query: 205 QEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPK-------------PLKRLNSEPWG 251
+K P P P +P+P+ P P P K P K + P
Sbjct: 460 PTTTKK------PAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 513
Query: 252 L--VAPPQPVPPTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGG 309
L P +P P T P A P + + P++P P K T+
Sbjct: 514 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA-- 571
Query: 310 PLSRRNTAPEA-QESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASP 368
P + + TAP +E P + + + P P D P + P
Sbjct: 572 PTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEP 631
Query: 369 LTLPPAGSAP-SPRQSQESLPGAVSPLSGRRRSPGLL---ERRGSGTLLLDHISQTRPGF 424
P AP +P+ + + +P + ++ +P L +G + D + T P
Sbjct: 632 APTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKE 691
Query: 425 LPPLNVSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTE 477
P +P P P +P P P PP +P T ++ H E
Sbjct: 692 TAP--TTPKEPAPTTPKKPAPTTPETP-PPTTSEVSTPTTTKEPTTIHKSPDE 741
Score = 57.0 bits (136), Expect = 4e-08
Identities = 79/348 (22%), Positives = 131/348 (37%), Gaps = 43/348 (12%)
Query: 147 DTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQE 206
+ +P+ TKK +P +P ++PAP +P T+P ++ T L+P E
Sbjct: 457 EPAPTTTKKP-----APTTP--KEPAPTTPKETAPTTPKKLTPTTPE-----KLAPTTPE 504
Query: 207 -------EEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPV 259
EE E P P P++P+P+ P P P +P EP P +P
Sbjct: 505 KPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP-APTTPKEPA 563
Query: 260 P--PTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTS-----GGPLS 312
P P E P + TA T P + E P ++ TS P +
Sbjct: 564 PTTPKETAPTTPKGTAP----TTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTT 619
Query: 313 RRNTAPEAQESGPPSGLRQKL----SRMEPVELDTPGHLCPDSPESSRLSLERRRYSASP 368
+ TAP + P+ ++ P L P P P L+ + S
Sbjct: 620 PKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTST 679
Query: 369 LTLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPL 428
+ PA + +P+++ + P +P + ++ +P E T + + T+ +
Sbjct: 680 TSDKPAPT--TPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEP--TTI 735
Query: 429 NVSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQT 476
+ SP P++ +P +A L P PG P TK + M T
Sbjct: 736 HKSPDESTPELSAEPTPKA--LENSP--KEPGVPTTKTPAATKPEMTT 779
Score = 49.7 bits (117), Expect = 6e-06
Identities = 54/260 (20%), Positives = 86/260 (33%), Gaps = 19/260 (7%)
Query: 219 PKPPDDPSPSEPLPKPPRHP-PKPLKRLNSEPW---------GLVAPPQPVPPTEGRPGI 268
PK P +P EP P+ P P +K + P P +P P T P
Sbjct: 213 PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPA- 271
Query: 269 ERLTAEFNGLTLTGRPR-LSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPS 327
T + T T P + + + P++P P K + P + + AP + P+
Sbjct: 272 -PTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPA--PTTPKEPAPTTPKEPTPT 328
Query: 328 GLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLT-LPPAGSAPSPRQSQES 386
++ + TP P +P+ + + +P P PSP +E
Sbjct: 329 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP 388
Query: 387 LPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRPQPGGR 446
P + P + + T + T P +P P P +P
Sbjct: 389 APTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK---EPAPTTPKEPAPTTPKKPAPT 445
Query: 447 APSLPAPPYAGAPGSPRTKR 466
P PAP P TK+
Sbjct: 446 TPKEPAPTTPKEPAPTTTKK 465
Score = 44.7 bits (104), Expect = 2e-04
Identities = 54/256 (21%), Positives = 86/256 (33%), Gaps = 25/256 (9%)
Query: 220 KPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRPGIERLTAEFNGLT 279
K P +P EP P P+ P + EP P P E P T
Sbjct: 206 KGPALTTPKEPTPTTPKEPASTTPK---EPTPTTIKSAPTTPKEPAP---TTTKSAPTTP 259
Query: 280 LTGRPRLSRRHSTEGPEDPPPWAEK-----VTSGGPLSRRNTAPEAQESGPPSGLRQ--K 332
P ++ + P++P P K T P + + AP + P+ ++
Sbjct: 260 KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAP 319
Query: 333 LSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGSAPSPRQSQESLPGAV- 391
+ EP TP P + E + + + +A P P+P +E P
Sbjct: 320 TTPKEPTP-TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 378
Query: 392 --SPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRPQPGGRAPS 449
SP + + +P + + T + P +P P P +P P
Sbjct: 379 EPSPTTPKEPAPTTTKSAPTTT------KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK 432
Query: 450 LPAP--PYAGAPGSPR 463
PAP P AP +P+
Sbjct: 433 EPAPTTPKKPAPTTPK 448
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 63.9 bits (154), Expect = 3e-10
Identities = 70/329 (21%), Positives = 115/329 (34%), Gaps = 34/329 (10%)
Query: 147 DTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQE 206
+ +P+ TK P ++PAP +P T+ E T +P +
Sbjct: 287 EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS------APTTPK 340
Query: 207 EEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRP 266
E P P P P+P+ P P P +P EP P P P E P
Sbjct: 341 E---------PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP 391
Query: 267 GIERLTAEFN------GLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEA 320
+ A P ++ S P++P P T P + + AP
Sbjct: 392 TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP---TTTKSAPTTTKEPAPTT 448
Query: 321 QESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGS---A 377
+S P + + + TP P +P+ + + +P P + A
Sbjct: 449 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 508
Query: 378 P-SPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPI 436
P +P++ + P +P + ++ +P E+ T + + T P L P +P P
Sbjct: 509 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT--PEKPAPTTPEELAP--TTPEEPT 564
Query: 437 PDIRPQPGGRAPSLPAP--PYAGAPGSPR 463
P +P P AP P AP +P+
Sbjct: 565 PTTPEEPAPTTPKAAAPNTPKEPAPTTPK 593
Score = 61.6 bits (148), Expect = 2e-09
Identities = 70/324 (21%), Positives = 114/324 (35%), Gaps = 51/324 (15%)
Query: 145 TTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRA 204
T + +P+ TK P + PAP +P T+P E P
Sbjct: 324 TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE---------------PTP 368
Query: 205 QEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVA-PPQPVPPTE 263
+E + P P P +P+P+ P P P +P EP P P P E
Sbjct: 369 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKE 428
Query: 264 GRPGIERLTAEFNGLTLTGRPR-LSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQE 322
P T + T T P + + + P++P P K P + + AP +
Sbjct: 429 PAP-----TTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK--EPAPTTPKEPAPTTPK 481
Query: 323 SGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGSAP-SPR 381
P+ TP P +P+ + ++ P P AP +P+
Sbjct: 482 KPAPT---------------TPKEPAPTTPKEPAPTTTKK-----PAPTTPKEPAPTTPK 521
Query: 382 QSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRP 441
++ + P ++P + + +P E+ T + ++ T P P +P P P
Sbjct: 522 ETAPTTPKKLTPTTPEKLAPTTPEKPAPTT--PEELAPTTPE--EPTPTTPEEPAPTTPK 577
Query: 442 QPGGRAPSLPAP--PYAGAPGSPR 463
P PAP P AP +P+
Sbjct: 578 AAAPNTPKEPAPTTPKEPAPTTPK 601
Score = 57.0 bits (136), Expect = 4e-08
Identities = 74/353 (20%), Positives = 117/353 (33%), Gaps = 31/353 (8%)
Query: 145 TTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRA 204
T + +P+ TK P ++PAP +P T+P + T A
Sbjct: 441 TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 500
Query: 205 QEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPK-------------PLKRLNSEPWG 251
+K P P P +P+P+ P P P K P K + P
Sbjct: 501 PTTTKK------PAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 554
Query: 252 L--VAPPQPVPPTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGG 309
L P +P P T P A P + + P++P P K T+
Sbjct: 555 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA-- 612
Query: 310 PLSRRNTAPEA-QESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASP 368
P + + TAP +E P + + + P P D P + P
Sbjct: 613 PTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEP 672
Query: 369 LTLPPAGSAP-SPRQSQESLPGAVSPLSGRRRSPGLL---ERRGSGTLLLDHISQTRPGF 424
P AP +P+ + + +P + ++ +P L +G + D + T P
Sbjct: 673 APTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKE 732
Query: 425 LPPLNVSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTE 477
P +P P P +P P P PP +P T ++ H E
Sbjct: 733 TAP--TTPKEPAPTTPKKPAPTTPETP-PPTTSEVSTPTTTKEPTTIHKSPDE 782
Score = 57.0 bits (136), Expect = 4e-08
Identities = 79/348 (22%), Positives = 131/348 (37%), Gaps = 43/348 (12%)
Query: 147 DTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQE 206
+ +P+ TKK +P +P ++PAP +P T+P ++ T L+P E
Sbjct: 498 EPAPTTTKKP-----APTTP--KEPAPTTPKETAPTTPKKLTPTTPE-----KLAPTTPE 545
Query: 207 -------EEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPV 259
EE E P P P++P+P+ P P P +P EP P +P
Sbjct: 546 KPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP-APTTPKEPA 604
Query: 260 P--PTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTS-----GGPLS 312
P P E P + TA T P + E P ++ TS P +
Sbjct: 605 PTTPKETAPTTPKGTAP----TTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTT 660
Query: 313 RRNTAPEAQESGPPSGLRQKL----SRMEPVELDTPGHLCPDSPESSRLSLERRRYSASP 368
+ TAP + P+ ++ P L P P P L+ + S
Sbjct: 661 PKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTST 720
Query: 369 LTLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPL 428
+ PA + +P+++ + P +P + ++ +P E T + + T+ +
Sbjct: 721 TSDKPAPT--TPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEP--TTI 776
Query: 429 NVSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQT 476
+ SP P++ +P +A L P PG P TK + M T
Sbjct: 777 HKSPDESTPELSAEPTPKA--LENSP--KEPGVPTTKTPAATKPEMTT 820
Score = 49.7 bits (117), Expect = 6e-06
Identities = 54/260 (20%), Positives = 86/260 (33%), Gaps = 19/260 (7%)
Query: 219 PKPPDDPSPSEPLPKPPRHP-PKPLKRLNSEPW---------GLVAPPQPVPPTEGRPGI 268
PK P +P EP P+ P P +K + P P +P P T P
Sbjct: 254 PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPA- 312
Query: 269 ERLTAEFNGLTLTGRPR-LSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPS 327
T + T T P + + + P++P P K + P + + AP + P+
Sbjct: 313 -PTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPA--PTTPKEPAPTTPKEPTPT 369
Query: 328 GLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLT-LPPAGSAPSPRQSQES 386
++ + TP P +P+ + + +P P PSP +E
Sbjct: 370 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP 429
Query: 387 LPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRPQPGGR 446
P + P + + T + T P +P P P +P
Sbjct: 430 APTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK---EPAPTTPKEPAPTTPKKPAPT 486
Query: 447 APSLPAPPYAGAPGSPRTKR 466
P PAP P TK+
Sbjct: 487 TPKEPAPTTPKEPAPTTTKK 506
Score = 44.7 bits (104), Expect = 2e-04
Identities = 54/256 (21%), Positives = 86/256 (33%), Gaps = 25/256 (9%)
Query: 220 KPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRPGIERLTAEFNGLT 279
K P +P EP P P+ P + EP P P E P T
Sbjct: 247 KGPALTTPKEPTPTTPKEPASTTPK---EPTPTTIKSAPTTPKEPAP---TTTKSAPTTP 300
Query: 280 LTGRPRLSRRHSTEGPEDPPPWAEK-----VTSGGPLSRRNTAPEAQESGPPSGLRQ--K 332
P ++ + P++P P K T P + + AP + P+ ++
Sbjct: 301 KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAP 360
Query: 333 LSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGSAPSPRQSQESLPGAV- 391
+ EP TP P + E + + + +A P P+P +E P
Sbjct: 361 TTPKEPTP-TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 419
Query: 392 --SPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRPQPGGRAPS 449
SP + + +P + + T + P +P P P +P P
Sbjct: 420 EPSPTTPKEPAPTTTKSAPTTT------KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK 473
Query: 450 LPAP--PYAGAPGSPR 463
PAP P AP +P+
Sbjct: 474 EPAPTTPKKPAPTTPK 489
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 63.9 bits (154), Expect = 3e-10
Identities = 70/329 (21%), Positives = 115/329 (34%), Gaps = 34/329 (10%)
Query: 147 DTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQE 206
+ +P+ TK P ++PAP +P T+ E T +P +
Sbjct: 339 EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS------APTTPK 392
Query: 207 EEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRP 266
E P P P P+P+ P P P +P EP P P P E P
Sbjct: 393 E---------PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP 443
Query: 267 GIERLTAEFN------GLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEA 320
+ A P ++ S P++P P T P + + AP
Sbjct: 444 TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP---TTTKSAPTTTKEPAPTT 500
Query: 321 QESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGS---A 377
+S P + + + TP P +P+ + + +P P + A
Sbjct: 501 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 560
Query: 378 P-SPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPI 436
P +P++ + P +P + ++ +P E+ T + + T P L P +P P
Sbjct: 561 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT--PEKPAPTTPEELAP--TTPEEPT 616
Query: 437 PDIRPQPGGRAPSLPAP--PYAGAPGSPR 463
P +P P AP P AP +P+
Sbjct: 617 PTTPEEPAPTTPKAAAPNTPKEPAPTTPK 645
Score = 61.6 bits (148), Expect = 2e-09
Identities = 70/324 (21%), Positives = 114/324 (35%), Gaps = 51/324 (15%)
Query: 145 TTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRA 204
T + +P+ TK P + PAP +P T+P E P
Sbjct: 376 TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE---------------PTP 420
Query: 205 QEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVA-PPQPVPPTE 263
+E + P P P +P+P+ P P P +P EP P P P E
Sbjct: 421 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKE 480
Query: 264 GRPGIERLTAEFNGLTLTGRPR-LSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQE 322
P T + T T P + + + P++P P K P + + AP +
Sbjct: 481 PAP-----TTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK--EPAPTTPKEPAPTTPK 533
Query: 323 SGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGSAP-SPR 381
P+ TP P +P+ + ++ P P AP +P+
Sbjct: 534 KPAPT---------------TPKEPAPTTPKEPAPTTTKK-----PAPTTPKEPAPTTPK 573
Query: 382 QSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRP 441
++ + P ++P + + +P E+ T + ++ T P P +P P P
Sbjct: 574 ETAPTTPKKLTPTTPEKLAPTTPEKPAPTT--PEELAPTTPE--EPTPTTPEEPAPTTPK 629
Query: 442 QPGGRAPSLPAP--PYAGAPGSPR 463
P PAP P AP +P+
Sbjct: 630 AAAPNTPKEPAPTTPKEPAPTTPK 653
Score = 57.0 bits (136), Expect = 4e-08
Identities = 74/353 (20%), Positives = 117/353 (33%), Gaps = 31/353 (8%)
Query: 145 TTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRA 204
T + +P+ TK P ++PAP +P T+P + T A
Sbjct: 493 TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 552
Query: 205 QEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPK-------------PLKRLNSEPWG 251
+K P P P +P+P+ P P P K P K + P
Sbjct: 553 PTTTKK------PAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 606
Query: 252 L--VAPPQPVPPTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGG 309
L P +P P T P A P + + P++P P K T+
Sbjct: 607 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA-- 664
Query: 310 PLSRRNTAPEA-QESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASP 368
P + + TAP +E P + + + P P D P + P
Sbjct: 665 PTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEP 724
Query: 369 LTLPPAGSAP-SPRQSQESLPGAVSPLSGRRRSPGLL---ERRGSGTLLLDHISQTRPGF 424
P AP +P+ + + +P + ++ +P L +G + D + T P
Sbjct: 725 APTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKE 784
Query: 425 LPPLNVSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTE 477
P +P P P +P P P PP +P T ++ H E
Sbjct: 785 TAP--TTPKEPAPTTPKKPAPTTPETP-PPTTSEVSTPTTTKEPTTIHKSPDE 834
Score = 57.0 bits (136), Expect = 4e-08
Identities = 79/348 (22%), Positives = 131/348 (37%), Gaps = 43/348 (12%)
Query: 147 DTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQE 206
+ +P+ TKK +P +P ++PAP +P T+P ++ T L+P E
Sbjct: 550 EPAPTTTKKP-----APTTP--KEPAPTTPKETAPTTPKKLTPTTPE-----KLAPTTPE 597
Query: 207 -------EEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPV 259
EE E P P P++P+P+ P P P +P EP P +P
Sbjct: 598 KPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP-APTTPKEPA 656
Query: 260 P--PTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTS-----GGPLS 312
P P E P + TA T P + E P ++ TS P +
Sbjct: 657 PTTPKETAPTTPKGTAP----TTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTT 712
Query: 313 RRNTAPEAQESGPPSGLRQKL----SRMEPVELDTPGHLCPDSPESSRLSLERRRYSASP 368
+ TAP + P+ ++ P L P P P L+ + S
Sbjct: 713 PKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTST 772
Query: 369 LTLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPL 428
+ PA + +P+++ + P +P + ++ +P E T + + T+ +
Sbjct: 773 TSDKPAPT--TPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEP--TTI 828
Query: 429 NVSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQT 476
+ SP P++ +P +A L P PG P TK + M T
Sbjct: 829 HKSPDESTPELSAEPTPKA--LENSP--KEPGVPTTKTPAATKPEMTT 872
Score = 49.7 bits (117), Expect = 6e-06
Identities = 54/260 (20%), Positives = 86/260 (33%), Gaps = 19/260 (7%)
Query: 219 PKPPDDPSPSEPLPKPPRHP-PKPLKRLNSEPW---------GLVAPPQPVPPTEGRPGI 268
PK P +P EP P+ P P +K + P P +P P T P
Sbjct: 306 PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPA- 364
Query: 269 ERLTAEFNGLTLTGRPR-LSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPS 327
T + T T P + + + P++P P K + P + + AP + P+
Sbjct: 365 -PTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPA--PTTPKEPAPTTPKEPTPT 421
Query: 328 GLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLT-LPPAGSAPSPRQSQES 386
++ + TP P +P+ + + +P P PSP +E
Sbjct: 422 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP 481
Query: 387 LPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRPQPGGR 446
P + P + + T + T P +P P P +P
Sbjct: 482 APTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK---EPAPTTPKEPAPTTPKKPAPT 538
Query: 447 APSLPAPPYAGAPGSPRTKR 466
P PAP P TK+
Sbjct: 539 TPKEPAPTTPKEPAPTTTKK 558
Score = 44.7 bits (104), Expect = 2e-04
Identities = 54/256 (21%), Positives = 86/256 (33%), Gaps = 25/256 (9%)
Query: 220 KPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRPGIERLTAEFNGLT 279
K P +P EP P P+ P + EP P P E P T
Sbjct: 299 KGPALTTPKEPTPTTPKEPASTTPK---EPTPTTIKSAPTTPKEPAP---TTTKSAPTTP 352
Query: 280 LTGRPRLSRRHSTEGPEDPPPWAEK-----VTSGGPLSRRNTAPEAQESGPPSGLRQ--K 332
P ++ + P++P P K T P + + AP + P+ ++
Sbjct: 353 KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAP 412
Query: 333 LSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGSAPSPRQSQESLPGAV- 391
+ EP TP P + E + + + +A P P+P +E P
Sbjct: 413 TTPKEPTP-TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 471
Query: 392 --SPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRPQPGGRAPS 449
SP + + +P + + T + P +P P P +P P
Sbjct: 472 EPSPTTPKEPAPTTTKSAPTTT------KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK 525
Query: 450 LPAP--PYAGAPGSPR 463
PAP P AP +P+
Sbjct: 526 EPAPTTPKKPAPTTPK 541
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 63.9 bits (154), Expect = 3e-10
Identities = 70/329 (21%), Positives = 115/329 (34%), Gaps = 34/329 (10%)
Query: 147 DTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQE 206
+ +P+ TK P ++PAP +P T+ E T +P +
Sbjct: 380 EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS------APTTPK 433
Query: 207 EEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRP 266
E P P P P+P+ P P P +P EP P P P E P
Sbjct: 434 E---------PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP 484
Query: 267 GIERLTAEFN------GLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEA 320
+ A P ++ S P++P P T P + + AP
Sbjct: 485 TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP---TTTKSAPTTTKEPAPTT 541
Query: 321 QESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGS---A 377
+S P + + + TP P +P+ + + +P P + A
Sbjct: 542 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 601
Query: 378 P-SPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPI 436
P +P++ + P +P + ++ +P E+ T + + T P L P +P P
Sbjct: 602 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT--PEKPAPTTPEELAP--TTPEEPT 657
Query: 437 PDIRPQPGGRAPSLPAP--PYAGAPGSPR 463
P +P P AP P AP +P+
Sbjct: 658 PTTPEEPAPTTPKAAAPNTPKEPAPTTPK 686
Score = 61.6 bits (148), Expect = 2e-09
Identities = 70/324 (21%), Positives = 114/324 (35%), Gaps = 51/324 (15%)
Query: 145 TTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRA 204
T + +P+ TK P + PAP +P T+P E P
Sbjct: 417 TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE---------------PTP 461
Query: 205 QEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVA-PPQPVPPTE 263
+E + P P P +P+P+ P P P +P EP P P P E
Sbjct: 462 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKE 521
Query: 264 GRPGIERLTAEFNGLTLTGRPR-LSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQE 322
P T + T T P + + + P++P P K P + + AP +
Sbjct: 522 PAP-----TTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK--EPAPTTPKEPAPTTPK 574
Query: 323 SGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGSAP-SPR 381
P+ TP P +P+ + ++ P P AP +P+
Sbjct: 575 KPAPT---------------TPKEPAPTTPKEPAPTTTKK-----PAPTTPKEPAPTTPK 614
Query: 382 QSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRP 441
++ + P ++P + + +P E+ T + ++ T P P +P P P
Sbjct: 615 ETAPTTPKKLTPTTPEKLAPTTPEKPAPTT--PEELAPTTPE--EPTPTTPEEPAPTTPK 670
Query: 442 QPGGRAPSLPAP--PYAGAPGSPR 463
P PAP P AP +P+
Sbjct: 671 AAAPNTPKEPAPTTPKEPAPTTPK 694
Score = 57.0 bits (136), Expect = 4e-08
Identities = 74/353 (20%), Positives = 117/353 (33%), Gaps = 31/353 (8%)
Query: 145 TTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRA 204
T + +P+ TK P ++PAP +P T+P + T A
Sbjct: 534 TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 593
Query: 205 QEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPK-------------PLKRLNSEPWG 251
+K P P P +P+P+ P P P K P K + P
Sbjct: 594 PTTTKK------PAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 647
Query: 252 L--VAPPQPVPPTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGG 309
L P +P P T P A P + + P++P P K T+
Sbjct: 648 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA-- 705
Query: 310 PLSRRNTAPEA-QESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASP 368
P + + TAP +E P + + + P P D P + P
Sbjct: 706 PTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEP 765
Query: 369 LTLPPAGSAP-SPRQSQESLPGAVSPLSGRRRSPGLL---ERRGSGTLLLDHISQTRPGF 424
P AP +P+ + + +P + ++ +P L +G + D + T P
Sbjct: 766 APTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKE 825
Query: 425 LPPLNVSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTE 477
P +P P P +P P P PP +P T ++ H E
Sbjct: 826 TAP--TTPKEPAPTTPKKPAPTTPETP-PPTTSEVSTPTTTKEPTTIHKSPDE 875
Score = 57.0 bits (136), Expect = 4e-08
Identities = 79/348 (22%), Positives = 131/348 (37%), Gaps = 43/348 (12%)
Query: 147 DTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQE 206
+ +P+ TKK +P +P ++PAP +P T+P ++ T L+P E
Sbjct: 591 EPAPTTTKKP-----APTTP--KEPAPTTPKETAPTTPKKLTPTTPE-----KLAPTTPE 638
Query: 207 -------EEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPV 259
EE E P P P++P+P+ P P P +P EP P +P
Sbjct: 639 KPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP-APTTPKEPA 697
Query: 260 P--PTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTS-----GGPLS 312
P P E P + TA T P + E P ++ TS P +
Sbjct: 698 PTTPKETAPTTPKGTAP----TTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTT 753
Query: 313 RRNTAPEAQESGPPSGLRQKL----SRMEPVELDTPGHLCPDSPESSRLSLERRRYSASP 368
+ TAP + P+ ++ P L P P P L+ + S
Sbjct: 754 PKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTST 813
Query: 369 LTLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPL 428
+ PA + +P+++ + P +P + ++ +P E T + + T+ +
Sbjct: 814 TSDKPAPT--TPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEP--TTI 869
Query: 429 NVSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQT 476
+ SP P++ +P +A L P PG P TK + M T
Sbjct: 870 HKSPDESTPELSAEPTPKA--LENSP--KEPGVPTTKTPAATKPEMTT 913
Score = 49.7 bits (117), Expect = 6e-06
Identities = 54/260 (20%), Positives = 86/260 (33%), Gaps = 19/260 (7%)
Query: 219 PKPPDDPSPSEPLPKPPRHP-PKPLKRLNSEPW---------GLVAPPQPVPPTEGRPGI 268
PK P +P EP P+ P P +K + P P +P P T P
Sbjct: 347 PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPA- 405
Query: 269 ERLTAEFNGLTLTGRPR-LSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPS 327
T + T T P + + + P++P P K + P + + AP + P+
Sbjct: 406 -PTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPA--PTTPKEPAPTTPKEPTPT 462
Query: 328 GLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLT-LPPAGSAPSPRQSQES 386
++ + TP P +P+ + + +P P PSP +E
Sbjct: 463 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP 522
Query: 387 LPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRPQPGGR 446
P + P + + T + T P +P P P +P
Sbjct: 523 APTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK---EPAPTTPKEPAPTTPKKPAPT 579
Query: 447 APSLPAPPYAGAPGSPRTKR 466
P PAP P TK+
Sbjct: 580 TPKEPAPTTPKEPAPTTTKK 599
Score = 44.7 bits (104), Expect = 2e-04
Identities = 54/256 (21%), Positives = 86/256 (33%), Gaps = 25/256 (9%)
Query: 220 KPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRPGIERLTAEFNGLT 279
K P +P EP P P+ P + EP P P E P T
Sbjct: 340 KGPALTTPKEPTPTTPKEPASTTPK---EPTPTTIKSAPTTPKEPAP---TTTKSAPTTP 393
Query: 280 LTGRPRLSRRHSTEGPEDPPPWAEK-----VTSGGPLSRRNTAPEAQESGPPSGLRQ--K 332
P ++ + P++P P K T P + + AP + P+ ++
Sbjct: 394 KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAP 453
Query: 333 LSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGSAPSPRQSQESLPGAV- 391
+ EP TP P + E + + + +A P P+P +E P
Sbjct: 454 TTPKEPTP-TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 512
Query: 392 --SPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRPQPGGRAPS 449
SP + + +P + + T + P +P P P +P P
Sbjct: 513 EPSPTTPKEPAPTTTKSAPTTT------KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK 566
Query: 450 LPAP--PYAGAPGSPR 463
PAP P AP +P+
Sbjct: 567 EPAPTTPKKPAPTTPK 582
>gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo
sapiens]
Length = 466
Score = 63.9 bits (154), Expect = 3e-10
Identities = 43/101 (42%), Positives = 56/101 (55%), Gaps = 3/101 (2%)
Query: 21 ARLLLEGGAYVNEGDAQGETALMAACRA--RYDDPQNKARMVRYLLEQGADPNIADRLGR 78
ARL L GA+V+ + +GETAL AAC A R D+ R+ LL +GA+ + D R
Sbjct: 235 ARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDER 294
Query: 79 TALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHAL 119
+ L AC G ++A LLL HGAD D+ GAS L L
Sbjct: 295 SPLHKAC-GHASHSLARLLLRHGADAGALDYGGASPLGRVL 334
Score = 42.0 bits (97), Expect = 0.001
Identities = 28/56 (50%), Positives = 33/56 (58%), Gaps = 2/56 (3%)
Query: 60 VRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASAL 115
VR+LL +GADP+ A GR AL AC GG A V LLL H ADP + G + L
Sbjct: 136 VRHLLGRGADPD-ASPGGRGALHEACLGGHTACVR-LLLQHRADPDLLSAEGLAPL 189
Score = 33.1 bits (74), Expect = 0.60
Identities = 36/114 (31%), Positives = 43/114 (37%), Gaps = 13/114 (11%)
Query: 12 AVGQGKLRLARLLLEGGAYVNEGDAQ--GETALMAACRARYDDPQNKARMVRYLLEQGAD 69
A G R LL GA + DA G AL AC + VR LL+ AD
Sbjct: 127 AAAHGHTACVRHLLGRGA---DPDASPGGRGALHEACLGGH------TACVRLLLQHRAD 177
Query: 70 PNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVH-ALDRG 122
P++ G A +H C A LL HGA G +H A RG
Sbjct: 178 PDLLSAEG-LAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRG 230
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 63.2 bits (152), Expect = 5e-10
Identities = 69/252 (27%), Positives = 93/252 (36%), Gaps = 30/252 (11%)
Query: 9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDD---------------- 52
L+ A +G L L + LL GA V+ A G+TAL AC + D
Sbjct: 568 LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 627
Query: 53 -----PQNKARM------VRYLLEQGADPN-IADRLGRTALMHACAGGGGAAVASLLLAH 100
P KA V++L+ +GA+ N T L ACAGG AV LLLAH
Sbjct: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGH-LAVVELLLAH 686
Query: 101 GADPSVRDHAGASALVHALDRGDRETLATLLD-ACKAKGTEVIIITTDTSPSGTKKTRQY 159
GADP+ R G++ L+ A G + LLD +T T PS
Sbjct: 687 GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPR 746
Query: 160 LNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLP 219
+ P V P P + I+ + G M + + P P
Sbjct: 747 VPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTP 806
Query: 220 KPPDDPSPSEPL 231
P PS P+
Sbjct: 807 SPIISPSAMLPI 818
Score = 56.6 bits (135), Expect = 5e-08
Identities = 42/132 (31%), Positives = 63/132 (47%), Gaps = 10/132 (7%)
Query: 4 TEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYL 63
++ +L A +G + R LL G VNE +GE+ L AC A Y + + + L
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYE------LAQVL 286
Query: 64 LEQGADPNIADR--LGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDR 121
L A N+ DR G + A A GG + LLLAH AD + + G +AL +A
Sbjct: 287 LAMHA--NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344
Query: 122 GDRETLATLLDA 133
G + + LL++
Sbjct: 345 GYVDVVKVLLES 356
Score = 55.8 bits (133), Expect = 9e-08
Identities = 51/133 (38%), Positives = 64/133 (48%), Gaps = 10/133 (7%)
Query: 3 HTE-GHA-LLRAVGQGKLRLARLLLEGGAYVNEGDAQ-GETALMAACRARYDDPQNKARM 59
H E GH L+ A G + +ARLLLE GA +N + E+AL AC + M
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACY------KGHLEM 416
Query: 60 VRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHAL 119
VR+LLE GAD TALM AC G VA LLL GA ++ + S L A
Sbjct: 417 VRFLLEAGADQEHKTDEMHTALMEACM-DGHVEVARLLLDSGAQVNMPADSFESPLTLAA 475
Query: 120 DRGDRETLATLLD 132
G E A L++
Sbjct: 476 CGGHVELAALLIE 488
Score = 48.1 bits (113), Expect = 2e-05
Identities = 48/159 (30%), Positives = 64/159 (40%), Gaps = 37/159 (23%)
Query: 5 EGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLL 64
E L A G G + LA LL+E GA + E + +G T LM A R +++ MV LL
Sbjct: 468 ESPLTLAACG-GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEE------MVALLL 520
Query: 65 EQGADPNI-ADRLGRTALMHACAGG-----------------------------GGAAVA 94
QGA+ N + TAL AC GG G +
Sbjct: 521 GQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELV 580
Query: 95 SLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDA 133
LLA GA+ G +AL +A + G + LL A
Sbjct: 581 KYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQA 619
Score = 46.2 bits (108), Expect = 7e-05
Identities = 43/127 (33%), Positives = 59/127 (46%), Gaps = 8/127 (6%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A G L + LLE GA + D +G T L+ A A + +V LL+ G
Sbjct: 835 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH------VGVVEILLDNG 888
Query: 68 ADPNI-ADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRET 126
AD ++R T L AC+GG V LLLA GA+ R+ + + L A G
Sbjct: 889 ADIEAQSERTKDTPLSLACSGGR-QEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNI 947
Query: 127 LATLLDA 133
+ LL+A
Sbjct: 948 IKILLNA 954
Score = 42.4 bits (98), Expect = 0.001
Identities = 49/164 (29%), Positives = 63/164 (38%), Gaps = 33/164 (20%)
Query: 12 AVGQGKLRLARLLLEGGAYVNE--GDAQGETALMAACRARYDDPQNKARMVRYLLEQGAD 69
A G + + ++LL GA +N G G + LM A V+ LL+ G+D
Sbjct: 939 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM------NGHTAAVKLLLDMGSD 992
Query: 70 PNIADRLGR-TALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLA 128
N R TAL AC G V SLLL A+ R G + L+ A G E
Sbjct: 993 INAQIETNRNTALTLACF-QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1051
Query: 129 TLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPA 172
LLD KG +V N+PP P D A
Sbjct: 1052 VLLD----KGADV-------------------NAPPVPSSRDTA 1072
Score = 41.2 bits (95), Expect = 0.002
Identities = 37/103 (35%), Positives = 50/103 (48%), Gaps = 12/103 (11%)
Query: 2 LHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETAL-MAACRARYDDPQNKARMV 60
+HT AL+ A G + +ARLLL+ GA VN E+ L +AAC + +
Sbjct: 434 MHT---ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE-------LA 483
Query: 61 RYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGAD 103
L+E+GA + G T LM A G VA LLL GA+
Sbjct: 484 ALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA-LLLGQGAN 525
Score = 41.2 bits (95), Expect = 0.002
Identities = 39/127 (30%), Positives = 53/127 (41%), Gaps = 7/127 (5%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A QG+ + LLL+ A V G T LM A Y A + R LL++G
Sbjct: 1004 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY------AEVGRVLLDKG 1057
Query: 68 ADPNIAD-RLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRET 126
AD N R + A G LL+ GA VR+ G + L A + G +
Sbjct: 1058 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDV 1117
Query: 127 LATLLDA 133
+ L+ A
Sbjct: 1118 VQLLVQA 1124
Score = 40.8 bits (94), Expect = 0.003
Identities = 81/404 (20%), Positives = 148/404 (36%), Gaps = 40/404 (9%)
Query: 9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQG--ETAL-MAACRARYDDPQNKARMVRYLLE 65
L+ A G + R+LL+ GA VN +TAL +AA + Y + L+
Sbjct: 1038 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY-------KFCELLIG 1090
Query: 66 QGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRE 125
+GA ++ ++ G T L A A GG V LL+ GAD D+ + L+ A +G +
Sbjct: 1091 RGAHIDVRNKKGNTPLWLA-ANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVK 1149
Query: 126 TLATLLDACKAKGTE---VIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCT 182
+ L+ ++ + I T T KK + S A A+ +
Sbjct: 1150 VVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILL 1209
Query: 183 SPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPL 242
+++ + + R + +E++R E K + + ++ + K
Sbjct: 1210 EELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEK 1269
Query: 243 KRLNSEPWGLVAPPQPVPPTEGRPGIERLTAEF--------NGLTLTGRPRLSRRHSTEG 294
++ EP L PP T GI N +T T R +R++
Sbjct: 1270 LKVEDEPEVLTEPPSATTTT--TIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKI-- 1325
Query: 295 PEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPES 354
P ++ PL + PE S + + + + + C D +
Sbjct: 1326 ----TPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISS----CSDESSN 1377
Query: 355 SRLSLERRRYSASPLTL------PPAGSAPSPRQSQESLPGAVS 392
S S + +S + +T P+ P++ ++S+ G S
Sbjct: 1378 SNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKAS 1421
Score = 35.0 bits (79), Expect = 0.16
Identities = 29/98 (29%), Positives = 44/98 (44%), Gaps = 6/98 (6%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A +G + LL+ GA+++ + +G T L A + D +V+ L++ G
Sbjct: 1072 ALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD------VVQLLVQAG 1125
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPS 105
AD + AD T LM A G V L+ PS
Sbjct: 1126 ADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS 1163
Score = 30.0 bits (66), Expect = 5.1
Identities = 22/54 (40%), Positives = 26/54 (48%), Gaps = 1/54 (1%)
Query: 79 TALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLD 132
TAL ACAGG V + LL GA RD G + L+ A G + LLD
Sbjct: 834 TALTLACAGGHEELVQT-LLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886
Score = 29.3 bits (64), Expect = 8.6
Identities = 33/137 (24%), Positives = 47/137 (34%), Gaps = 28/137 (20%)
Query: 145 TTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRA 204
T T P T K ++SP SP PA P SP + G ++ +
Sbjct: 1774 TNATYPMPTAKEHYPVSSPSSPS----PPAQPGGVSRNSPLD-----CGSASPNKVASSS 1824
Query: 205 QEEEEKRDVFEFPLPKPPDDPS-------------PSEPLPKPPRHP------PKPLKRL 245
++E V E +PP+ S P + + PR P P P R+
Sbjct: 1825 EQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRM 1884
Query: 246 NSEPWGLVAPPQPVPPT 262
P + P VP T
Sbjct: 1885 TVPPLATSSAPVAVPST 1901
>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 62.8 bits (151), Expect = 7e-10
Identities = 84/314 (26%), Positives = 101/314 (32%), Gaps = 77/314 (24%)
Query: 148 TSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQEE 207
++P + + SPP PG P PSPG P TA GGG SP
Sbjct: 189 STPRPIQSSPHNRGSPPVPG----GPRQPSPGPTPPPFPGNRGTALGGGSIRQSPL---- 240
Query: 208 EEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRPG 267
S S P P PP P + L+ +P P P PP RP
Sbjct: 241 ------------------SSSSPFSNRPPLPPTPSRALDDKP------PPPPPPVGNRPS 276
Query: 268 IERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPS 327
I R E PPP +N P + PS
Sbjct: 277 IHR----------------------EAVPPPPP-------------QNNKPPVPSTPRPS 301
Query: 328 GLRQKLSRMEPVELDTPGHLCPDSP---ESSRLSLERRRYSASPLTLP-PAGSAPSPRQS 383
Q P P L P S E+ RL S+S LP P S P P
Sbjct: 302 ASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPP 361
Query: 384 QESLPGAVSPLSGRRRS---PGLLERRGSGTLLLDHISQ--TRPGFLPPLNVSPHPPIPD 438
E P V GR P + R GS + L Q +R G P + P PP+P
Sbjct: 362 SERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRS-GPRPPLPP 420
Query: 439 IRPQPGGRAPSLPA 452
RP G P P+
Sbjct: 421 DRPSAGAPPPPPPS 434
Score = 55.8 bits (133), Expect = 9e-08
Identities = 91/325 (28%), Positives = 120/325 (36%), Gaps = 54/325 (16%)
Query: 151 SGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSP--RAQEEE 208
+G K R N G P P P G TS +G G + SP R+ E
Sbjct: 106 AGMPKLRSTANRDNDSGGSRP-PLLPPGGRSTSAKPFS-PPSGPGRFPVPSPGHRSGPPE 163
Query: 209 EKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRPGI 268
+R+ P P+P D S + +P P P+P++ S P +PP P P + PG
Sbjct: 164 PQRN--RMPPPRP-DVGSKPDSIPPPVPSTPRPIQ---SSPHNRGSPPVPGGPRQPSPGP 217
Query: 269 -------ERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQ 321
R TA G ++ P S + P PP T L + P
Sbjct: 218 TPPPFPGNRGTA-LGGGSIRQSPLSSSSPFSNRPPLPP------TPSRALDDKPPPPP-- 268
Query: 322 ESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGSAPSPR 381
PP G R + R E V P + P P + R S + A P PP+ P P
Sbjct: 269 ---PPVGNRPSIHR-EAVPPPPPQNNKPPVPSTPRPSASSQ---APPPPPPPSRPGPPP- 320
Query: 382 QSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRP 441
LP + S G +P L +R S +S + P P P PP P RP
Sbjct: 321 -----LPPSSS---GNDETPRLPQRNLS-------LSSSTPPLPSPGRSGPLPPPPSERP 365
Query: 442 -----QPGGRAPSLPAPPYAGAPGS 461
P GR+ LP PP GS
Sbjct: 366 PPPVRDPPGRSGPLPPPPPVSRNGS 390
Score = 40.4 bits (93), Expect = 0.004
Identities = 59/246 (23%), Positives = 80/246 (32%), Gaps = 69/246 (28%)
Query: 264 GRPGIERLTAEFNGLTLTGRPRL---SRRHSTEGPEDPP--PWAEKVTSGGPLS------ 312
G PG+ GL G P+L + R + G PP P + TS P S
Sbjct: 96 GPPGL-------GGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPG 148
Query: 313 RRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLP 372
R SGPP R ++ P P + P P + R P+
Sbjct: 149 RFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPR-----------PIQSS 197
Query: 373 P--AGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGF----LP 426
P GS P P ++ PG P R L G G++ +S + P LP
Sbjct: 198 PHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTAL----GGGSIRQSPLSSSSPFSNRPPLP 253
Query: 427 P-----LNVSPHPPIPDI-------------------------RPQPGGRAPSLPAPPYA 456
P L+ P PP P + P+P + + P PP
Sbjct: 254 PTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPP 313
Query: 457 GAPGSP 462
PG P
Sbjct: 314 SRPGPP 319
>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 62.8 bits (151), Expect = 7e-10
Identities = 84/314 (26%), Positives = 101/314 (32%), Gaps = 77/314 (24%)
Query: 148 TSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQEE 207
++P + + SPP PG P PSPG P TA GGG SP
Sbjct: 189 STPRPIQSSPHNRGSPPVPG----GPRQPSPGPTPPPFPGNRGTALGGGSIRQSPL---- 240
Query: 208 EEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRPG 267
S S P P PP P + L+ +P P P PP RP
Sbjct: 241 ------------------SSSSPFSNRPPLPPTPSRALDDKP------PPPPPPVGNRPS 276
Query: 268 IERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPS 327
I R E PPP +N P + PS
Sbjct: 277 IHR----------------------EAVPPPPP-------------QNNKPPVPSTPRPS 301
Query: 328 GLRQKLSRMEPVELDTPGHLCPDSP---ESSRLSLERRRYSASPLTLP-PAGSAPSPRQS 383
Q P P L P S E+ RL S+S LP P S P P
Sbjct: 302 ASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPP 361
Query: 384 QESLPGAVSPLSGRRRS---PGLLERRGSGTLLLDHISQ--TRPGFLPPLNVSPHPPIPD 438
E P V GR P + R GS + L Q +R G P + P PP+P
Sbjct: 362 SERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRS-GPRPPLPP 420
Query: 439 IRPQPGGRAPSLPA 452
RP G P P+
Sbjct: 421 DRPSAGAPPPPPPS 434
Score = 55.8 bits (133), Expect = 9e-08
Identities = 91/325 (28%), Positives = 120/325 (36%), Gaps = 54/325 (16%)
Query: 151 SGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSP--RAQEEE 208
+G K R N G P P P G TS +G G + SP R+ E
Sbjct: 106 AGMPKLRSTANRDNDSGGSRP-PLLPPGGRSTSAKPFS-PPSGPGRFPVPSPGHRSGPPE 163
Query: 209 EKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRPGI 268
+R+ P P+P D S + +P P P+P++ S P +PP P P + PG
Sbjct: 164 PQRN--RMPPPRP-DVGSKPDSIPPPVPSTPRPIQ---SSPHNRGSPPVPGGPRQPSPGP 217
Query: 269 -------ERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQ 321
R TA G ++ P S + P PP T L + P
Sbjct: 218 TPPPFPGNRGTA-LGGGSIRQSPLSSSSPFSNRPPLPP------TPSRALDDKPPPPP-- 268
Query: 322 ESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGSAPSPR 381
PP G R + R E V P + P P + R S + A P PP+ P P
Sbjct: 269 ---PPVGNRPSIHR-EAVPPPPPQNNKPPVPSTPRPSASSQ---APPPPPPPSRPGPPP- 320
Query: 382 QSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRP 441
LP + S G +P L +R S +S + P P P PP P RP
Sbjct: 321 -----LPPSSS---GNDETPRLPQRNLS-------LSSSTPPLPSPGRSGPLPPPPSERP 365
Query: 442 -----QPGGRAPSLPAPPYAGAPGS 461
P GR+ LP PP GS
Sbjct: 366 PPPVRDPPGRSGPLPPPPPVSRNGS 390
Score = 40.4 bits (93), Expect = 0.004
Identities = 59/246 (23%), Positives = 80/246 (32%), Gaps = 69/246 (28%)
Query: 264 GRPGIERLTAEFNGLTLTGRPRL---SRRHSTEGPEDPP--PWAEKVTSGGPLS------ 312
G PG+ GL G P+L + R + G PP P + TS P S
Sbjct: 96 GPPGL-------GGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPG 148
Query: 313 RRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLP 372
R SGPP R ++ P P + P P + R P+
Sbjct: 149 RFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPR-----------PIQSS 197
Query: 373 P--AGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGF----LP 426
P GS P P ++ PG P R L G G++ +S + P LP
Sbjct: 198 PHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTAL----GGGSIRQSPLSSSSPFSNRPPLP 253
Query: 427 P-----LNVSPHPPIPDI-------------------------RPQPGGRAPSLPAPPYA 456
P L+ P PP P + P+P + + P PP
Sbjct: 254 PTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPP 313
Query: 457 GAPGSP 462
PG P
Sbjct: 314 SRPGPP 319
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 62.8 bits (151), Expect = 7e-10
Identities = 92/343 (26%), Positives = 129/343 (37%), Gaps = 57/343 (16%)
Query: 162 SPPSPG---VEDP------APASPSPGFCTS-----PSEIQLQTAGGGGRGM-LSPRAQE 206
SPP PG ++P P G TS P +Q + G G+ L P+ +
Sbjct: 373 SPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEA 432
Query: 207 EEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQP-------- 258
+ E PL PP++ S P + P PP RL+ P L A P P
Sbjct: 433 PLNE----EMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRP 488
Query: 259 -------VPPTEGRPGIERLTAEFNGL---TLTGRPRLSRRHSTEGPEDPPPWAEKVTSG 308
PP E ++ F+ L L+ + E P PPP A ++
Sbjct: 489 LEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPP 548
Query: 309 GPLSRRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDS------PESSRLSLERR 362
S + PE + PP + SR+ P ++P P+ PE+SRL
Sbjct: 549 FEESPLSPPPEELPTSPP----PEASRLSPPPEESPMSPPPEESPMSPPPEASRLF---P 601
Query: 363 RYSASPLTLPPAGS--APSPRQSQESLPGAVSPLS-GRRRSPGLLERRGSGTLLLDHISQ 419
+ SPL+ PP S +P P S+ S P SP+S SP S L +S+
Sbjct: 602 PFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSR 661
Query: 420 TRPGFLPPLNVSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSP 462
PP SP P P+ P S +PP +P SP
Sbjct: 662 ----LSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSP 700
Score = 60.1 bits (144), Expect = 5e-09
Identities = 89/334 (26%), Positives = 115/334 (34%), Gaps = 67/334 (20%)
Query: 162 SPPSPGVEDPAPASP-----SPGF---CTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDV 213
SPPSP +E P P SP F SP +L T+ LSP +E
Sbjct: 526 SPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPP 585
Query: 214 FEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEP-WGLVAPPQPVPPTEGRPGIERLT 272
E P+ PP+ P + P PP L+ P ++PP P P
Sbjct: 586 EESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPP------ 639
Query: 273 AEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPSGLRQK 332
E P PPP +++ +SR + PE PP
Sbjct: 640 -------------------EESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPP------ 674
Query: 333 LSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGS--APSPRQSQESLPGA 390
P E T PE+SRLS SP + PP S +P P S SLP
Sbjct: 675 -----PEESPT-----SPPPEASRLSPPP---EDSPTSPPPEDSPASPPPEDSLMSLPLE 721
Query: 391 VSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRPQ--PGGRAP 448
SPL P L R H+S RP ++SP P P + PQ +P
Sbjct: 722 ESPLLPLPEEPQLCPRSEG-----PHLS-PRP---EEPHLSPRPEEPHLSPQAEEPHLSP 772
Query: 449 SLPAPPYAGAPGSPRTKRKLVRRH-SMQTEQIRL 481
P P P + H S Q E++ L
Sbjct: 773 QPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHL 806
Score = 53.1 bits (126), Expect = 6e-07
Identities = 82/344 (23%), Positives = 124/344 (36%), Gaps = 69/344 (20%)
Query: 142 IIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLS 201
I I + T+P+G + PP+ V P P SP F P ++ Q G L+
Sbjct: 2124 IFIGSPTTPAGLSTSADGFLKPPAGSV--PGPDSPGELFLKLPPQVPAQVPSQDPFG-LA 2180
Query: 202 PRAQEEEEKRDVFEFPL-PKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAP----- 255
P +PL P+ P P P P P P +P S G P
Sbjct: 2181 PA------------YPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHT 2228
Query: 256 -PQPVP---PTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPL 311
P P P+ P ++ + L + P + ++E PPP+ E +
Sbjct: 2229 TPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPFGES-RKALEV 2287
Query: 312 SRRNTAPEAQESGPPS-GLRQKLS---RMEPVELDTPGHL-CPDSPESSRLSLERRRYSA 366
+ + GPP+ G S + +EL TP P +P +S++ +
Sbjct: 2288 KKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQVEPQSPGLGL 2347
Query: 367 SPLTLPPAGS-APSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFL 425
P PPA + APSP + PG S T P
Sbjct: 2348 RPQEPPPAQALAPSPPSHPDIF------------RPG---------------SYTDPYAQ 2380
Query: 426 PPLNVSPHPPIPD----IRPQPGGRAPSLPAPPYAGAPGSPRTK 465
PPL P PP P+ + P+ SLP+ P++ P SP+++
Sbjct: 2381 PPLTPRPQPPPPESCCALPPR------SLPSDPFSRVPASPQSQ 2418
Score = 45.8 bits (107), Expect = 9e-05
Identities = 86/335 (25%), Positives = 115/335 (34%), Gaps = 61/335 (18%)
Query: 161 NSPPSPGVEDPAPASPSPGFCT-SPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLP 219
+SP SP E+ +P SP P SP + + + LSP +E L
Sbjct: 632 DSPMSPPPEE-SPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLS 690
Query: 220 KPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRPGIERLTAEFNGLT 279
PP+D S P P PP P L S P P+ P P +L G
Sbjct: 691 PPPEDSPTSPPPEDSPASPP-PEDSLMSLP----LEESPLLPLPEEP---QLCPRSEGPH 742
Query: 280 LTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPSGLRQKLSRMEPV 339
L+ RP H + PE+P + +P+A+E + P
Sbjct: 743 LSPRP--EEPHLSPRPEEP----------------HLSPQAEEPHLSPQPEEPCLCAVPE 784
Query: 340 ELDTPGHLCPDSPESSRLSLERRRYSASPLTLPPAGSAPSPRQSQESLPGAVSPLSGRRR 399
E HL P + E LS + SP T P S P P + S S LS +
Sbjct: 785 E----PHLSPQA-EGPHLSPQPEELHLSPQTEEPHLS-PVPEEPCLSPQPEESHLSPQSE 838
Query: 400 SPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRPQPGGRAPSLPAPPYAGAP 459
P L R H+S P L P P P+ P+ G+ P+ P P
Sbjct: 839 EPCLSPRPEE-----SHLS-------PELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPP 886
Query: 460 GSPRTKRKLVRRHSMQTEQIRLLGGFQSLGGPGEP 494
G P + L G +L PGEP
Sbjct: 887 GEP---------------SLSPLLGEPALSEPGEP 906
Score = 40.8 bits (94), Expect = 0.003
Identities = 96/363 (26%), Positives = 126/363 (34%), Gaps = 77/363 (21%)
Query: 146 TDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPG------------FCTSPSEIQLQTAG 193
T P ++ + +SP SP ED +PASP P P E QL
Sbjct: 680 TSPPPEASRLSPPPEDSPTSPPPED-SPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRS 738
Query: 194 GGGRGMLSPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLV 253
G LSPR +E L P++P S P + P P+P EP
Sbjct: 739 EGPH--LSPRPEEPH---------LSPRPEEPHLS-PQAEEPHLSPQP-----EEPCLCA 781
Query: 254 APPQP--VPPTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDP--PPWAEKVTSGG 309
P +P P EG L+ + L L+ P+ H + PE+P P E+
Sbjct: 782 VPEEPHLSPQAEG----PHLSPQPEELHLS--PQTEEPHLSPVPEEPCLSPQPEESHLSP 835
Query: 310 PLSRRNTAPEAQESG-PPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASP 368
+P +ES P + LS + PG CP +PE L S SP
Sbjct: 836 QSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQ-CP-APEELPLFPPPGEPSLSP 893
Query: 369 LTLPPAGSAPS-PRQSQ--ESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFL 425
L PA S P P S E LP +SP SP L+ L I+ P L
Sbjct: 894 LLGEPALSEPGEPPLSPLPEELP--LSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPAL 951
Query: 426 PPLN--------------------------VSPHPPIPDIRPQPGGRAPSLPAPPYAGAP 459
PL +SP P P+P P + PP G+P
Sbjct: 952 SPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEP---VPPMILPPSPGSP 1008
Query: 460 GSP 462
P
Sbjct: 1009 VGP 1011
Score = 38.9 bits (89), Expect = 0.011
Identities = 33/96 (34%), Positives = 42/96 (43%), Gaps = 19/96 (19%)
Query: 212 DVFEFPLPKPPDDPSPS-EPL-PKPPRHPPKPLKRLNSEPWGLVAPPQPVP-PTEGRPGI 268
DV + P PP++PSP PL P P P +PL L +EP L PP P P P P
Sbjct: 4902 DVRQLSAP-PPEEPSPPPSPLAPSPASPPTEPLVELPTEP--LAEPPVPSPLPLASSPE- 4957
Query: 269 ERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEK 304
+ RP+ R EG + PP +K
Sbjct: 4958 ------------SARPKPRARPPEEGEDSRPPRLKK 4981
Score = 37.7 bits (86), Expect = 0.024
Identities = 88/306 (28%), Positives = 113/306 (36%), Gaps = 65/306 (21%)
Query: 165 SPGVEDPAPASP-------SPGFCTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFP 217
SP +E P P SP PG C +P E+ L G LSP E + E P
Sbjct: 852 SPELEKP-PLSPRPEKPPEEPGQCPAPEELPLFPPPG--EPSLSPLLGEPALS-EPGEPP 907
Query: 218 L-PKPPDDP-SPS-EPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPTEGRPGIERLTAE 274
L P P + P SPS EP P PP PL S APP P E
Sbjct: 908 LSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGE----------- 956
Query: 275 FNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPSGLRQKLS 334
L +G DP P+S PEA + P
Sbjct: 957 -----------LEYPFGAKGDSDPESPLAAPILETPIS---PPPEANCTDP--------- 993
Query: 335 RMEPVELDTPGHLCPDSPES-----SRLSLERRRYSASPL---TLPPAGSAPSPRQSQES 386
EPV P + P SP S S + +E SPL +L P S PS + S +
Sbjct: 994 --EPV----PPMILPPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPS-QCSPPA 1046
Query: 387 LPGAV-SPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHP-PIPDIRPQPG 444
LP +V SPLS + G+ + + + +S+ L P SP P P+ D+
Sbjct: 1047 LPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSPLPSPMGDLSCPAP 1106
Query: 445 GRAPSL 450
AP+L
Sbjct: 1107 SPAPAL 1112
Score = 34.7 bits (78), Expect = 0.21
Identities = 67/277 (24%), Positives = 92/277 (33%), Gaps = 39/277 (14%)
Query: 189 LQTAGGGGRGML-SPRAQEEEEKRDVFEFPLPKPPDDP--------SPSEPLPKPPR--- 236
L TAGGG G L S + E + P D P P +P+ + P
Sbjct: 4108 LHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNN 4167
Query: 237 ---HPPKPLKRLNSEPWGLVAPPQPVPPTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTE 293
PPKP L S G P + PT G +L A+ G+ L P+L +
Sbjct: 4168 TGPQPPKPGPVLQS---GQGLPGVGIMPTVG-----QLRAQLQGV-LAKNPQLRHLSPQQ 4218
Query: 294 GPEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPE 353
+ ++ R+ P QE G + Q L +P PG P +
Sbjct: 4219 QQQLQALLMQRQLQQSQAVRQ--TPPYQEPGTQTSPLQGLLGCQPQLGGFPG---PQTGP 4273
Query: 354 SSRLSLERRRYSASPLTLPPAGSAPSPRQSQ-ESLPGAVSPLSGRRRSPGLLERRGSGTL 412
L R L PP + P P SP +R P L S
Sbjct: 4274 LQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKR--PSQLPSPSSQLP 4331
Query: 413 LLDHISQTRPGFLPPLNVSPHPPIPDIRPQPGGRAPS 449
+ T PG +P P P + P PG +P+
Sbjct: 4332 TEAQLPPTHPG-------TPKPQGPTLEPPPGRVSPA 4361
Score = 33.1 bits (74), Expect = 0.60
Identities = 33/128 (25%), Positives = 44/128 (34%), Gaps = 28/128 (21%)
Query: 157 RQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEF 216
RQ PP P+P +PSP + ++L T + E
Sbjct: 4904 RQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPT-------------------EPLAEP 4944
Query: 217 PLPKP-PDDPSPSEPLPKPPRHPPKP--------LKRLNSEPWGLVAPPQPVPPTEGRPG 267
P+P P P SP PKP PP+ LK+ W + + GR
Sbjct: 4945 PVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLKKWKGVRWKRLRLLLTIQKGSGRQE 5004
Query: 268 IERLTAEF 275
ER AEF
Sbjct: 5005 DEREVAEF 5012
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 62.4 bits (150), Expect = 9e-10
Identities = 48/151 (31%), Positives = 67/151 (44%), Gaps = 27/151 (17%)
Query: 9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDD---------------- 52
L+ A +G L L + LL GA V+ A G+TAL AC + D
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 53 -----PQNKARM------VRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHG 101
P KA V++L+ +GA+ N A ++ GG AV LLLAHG
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 102 ADPSVRDHAGASALVHALDRGDRETLATLLD 132
ADP+ R G++ L+ A G ++ LLD
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 55.1 bits (131), Expect = 1e-07
Identities = 47/153 (30%), Positives = 62/153 (40%), Gaps = 29/153 (18%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARY--------------DDP 53
+L A G + R LL+ G VNE +GE+ L AC A Y +D
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 54 QNKA--------------RMVRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLA 99
NK +V+ LL AD N G TAL +ACA GG + +LL
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA-GGFVDIVKVLLN 326
Query: 100 HGADPSVRDHAGASALVHALDRGDRETLATLLD 132
GA+ + G + L+ A G E LLD
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLD 359
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/133 (37%), Positives = 65/133 (48%), Gaps = 10/133 (7%)
Query: 3 HTE-GHA-LLRAVGQGKLRLARLLLEGGAYVNEGDAQ-GETALMAACRARYDDPQNKARM 59
H E GH L+ A G + +AR+LL+ GA +N + E+AL AC + D M
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD------M 387
Query: 60 VRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHAL 119
VR+LLE GAD TALM AC G VA LLL GA ++ + S L A
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACM-DGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446
Query: 120 DRGDRETLATLLD 132
G E A L++
Sbjct: 447 CGGHVELAALLIE 459
Score = 49.7 bits (117), Expect = 6e-06
Identities = 46/128 (35%), Positives = 63/128 (49%), Gaps = 12/128 (9%)
Query: 5 EGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLL 64
E L A G G + LA LL+E GA + E + +G T LM A R +++ MV LL
Sbjct: 439 ESPLTLAACG-GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEE------MVALLL 491
Query: 65 EQGADPNI-ADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGD 123
QGA+ N + TAL AC GG + VA L+ GAD + ++ L+ A G
Sbjct: 492 AQGANINAQTEETQETALTLACC-GGFSEVADFLIKAGADIEL---GCSTPLMEASQEGH 547
Query: 124 RETLATLL 131
E + LL
Sbjct: 548 LELVKYLL 555
Score = 46.6 bits (109), Expect = 5e-05
Identities = 72/335 (21%), Positives = 132/335 (39%), Gaps = 26/335 (7%)
Query: 9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQG--ETAL-MAACRARYDDPQNKARMVRYLLE 65
L+ A G + R+LL+ GA VN +TAL +AA + Y + L+
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY-------KFCELLIH 1313
Query: 66 QGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRE 125
+GA ++ ++ G T L A + GG V LL+ GAD D+ + L+ A +G +
Sbjct: 1314 RGAHIDVRNKKGNTPLWLA-SNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVK 1372
Query: 126 TLATLLDACKAKGTEV---IIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCT 182
+ L+ +++ I T T KK Q + + + A A+ +
Sbjct: 1373 VVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILL 1432
Query: 183 SPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPL 242
+++ + + + R + +E+++ E K +D E PK P+
Sbjct: 1433 KELDLEKSREESRKQALAAKREKRKEKRKKKKEEQKRKQEED---EENKPKENSELPEDE 1489
Query: 243 -KRLNSEPWGLVAPPQPVPPTEGRP-GIERLTAEFNGL------TLTGRPRLSRRHSTEG 294
+ N E P +P T GI +A F + + P +R++
Sbjct: 1490 DEEENDEDVEQEVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNK 1549
Query: 295 PEDPPPWAEKVTSGGPLS-RRNTAPEAQESGPPSG 328
++ PP A + +S + A + + +G P G
Sbjct: 1550 TKETPPTAHLILPEQHMSLAQQKADKNKINGEPRG 1584
Score = 43.5 bits (101), Expect = 4e-04
Identities = 45/134 (33%), Positives = 64/134 (47%), Gaps = 13/134 (9%)
Query: 2 LHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETAL-MAACRARYDDPQNKARMV 60
+HT AL+ A G + +ARLLL+ GA VN E+ L +AAC + +
Sbjct: 405 MHT---ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE-------LA 454
Query: 61 RYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVR-DHAGASALVHAL 119
L+E+GA+ + G T LM A G VA LLLA GA+ + + + +AL A
Sbjct: 455 ALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA-LLLAQGANINAQTEETQETALTLAC 513
Query: 120 DRGDRETLATLLDA 133
G E L+ A
Sbjct: 514 CGGFSEVADFLIKA 527
Score = 43.5 bits (101), Expect = 4e-04
Identities = 50/164 (30%), Positives = 64/164 (39%), Gaps = 33/164 (20%)
Query: 12 AVGQGKLRLARLLLEGGAYVNE--GDAQGETALMAACRARYDDPQNKARMVRYLLEQGAD 69
A G + + ++LL GA +N G G + LM A V+ LL+ G+D
Sbjct: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM------NGHVPAVKLLLDMGSD 1215
Query: 70 PNIADRLGR-TALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLA 128
N R TAL AC G A V SLLL A+ R G + L+ A G E
Sbjct: 1216 INAQIETNRNTALTLACF-QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1274
Query: 129 TLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPA 172
LLD KG +V N+PP P D A
Sbjct: 1275 VLLD----KGADV-------------------NAPPVPSSRDTA 1295
Score = 41.2 bits (95), Expect = 0.002
Identities = 41/131 (31%), Positives = 58/131 (44%), Gaps = 8/131 (6%)
Query: 4 TEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYL 63
T AL A G + + ++LL GA + + + G T LM A A + + R L
Sbjct: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGH------VEVARVL 357
Query: 64 LEQGADPNI-ADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRG 122
L+ GA N ++ +AL AC G V LL A GAD + +AL+ A G
Sbjct: 358 LDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA-GADQEHKTDEMHTALMEACMDG 416
Query: 123 DRETLATLLDA 133
E LLD+
Sbjct: 417 HVEVARLLLDS 427
Score = 41.2 bits (95), Expect = 0.002
Identities = 42/135 (31%), Positives = 61/135 (45%), Gaps = 11/135 (8%)
Query: 3 HTEGH---ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARM 59
HTE + AL A G L +L+ A + D +G T L+ A A + +
Sbjct: 1050 HTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGH------VGV 1103
Query: 60 VRYLLEQGADPNI-ADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHA 118
V LL++G D ++R T L AC+GG V LLLA GA+ R+ + + L A
Sbjct: 1104 VEILLDKGGDIEAQSERTKDTPLSLACSGGR-QEVVDLLLARGANKEHRNVSDYTPLSLA 1162
Query: 119 LDRGDRETLATLLDA 133
G + LL+A
Sbjct: 1163 ASGGYVNIIKILLNA 1177
Score = 36.2 bits (82), Expect = 0.071
Identities = 29/98 (29%), Positives = 44/98 (44%), Gaps = 6/98 (6%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A +G + LL+ GA+++ + +G T L A + D +V+ L++ G
Sbjct: 1295 ALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFD------VVQLLVQAG 1348
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPS 105
AD + AD T LM A G V L+ PS
Sbjct: 1349 ADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPS 1386
Score = 30.8 bits (68), Expect = 3.0
Identities = 63/274 (22%), Positives = 95/274 (34%), Gaps = 49/274 (17%)
Query: 148 TSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQEE 207
+SP+ T Q P S V D +P S + P+ + L SPR
Sbjct: 2068 SSPTPTSSNTQEEAQPSS--VSDLSPMSMPFASNSEPAPLTLT----------SPR-MVA 2114
Query: 208 EEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGL-VAPPQPVPPTEGRP 266
+ +D P P P+ + P ++ +P + V P + P +G P
Sbjct: 2115 ADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIFVTNPVTLTPPQGPP 2174
Query: 267 GIERLTAE---FNGLTLTGRPRLSRRHSTEGP-----------EDPPPWAEKVTSGGPLS 312
+L++ NG + P T GP + A + GPLS
Sbjct: 2175 AAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSSQVPANQGWGDGPLS 2234
Query: 313 RR---NTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPL 369
R + + Q + + + L M P PG P +R S SP+
Sbjct: 2235 SRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPS-----------QRVSTSPV 2283
Query: 370 TLP---PAGSAPS----PRQSQESLPGAVSPLSG 396
LP P+GS+PS P S +PG L G
Sbjct: 2284 GLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQG 2317
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 62.4 bits (150), Expect = 9e-10
Identities = 48/151 (31%), Positives = 67/151 (44%), Gaps = 27/151 (17%)
Query: 9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDD---------------- 52
L+ A +G L L + LL GA V+ A G+TAL AC + D
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 53 -----PQNKARM------VRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHG 101
P KA V++L+ +GA+ N A ++ GG AV LLLAHG
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 102 ADPSVRDHAGASALVHALDRGDRETLATLLD 132
ADP+ R G++ L+ A G ++ LLD
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 55.1 bits (131), Expect = 1e-07
Identities = 47/153 (30%), Positives = 62/153 (40%), Gaps = 29/153 (18%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARY--------------DDP 53
+L A G + R LL+ G VNE +GE+ L AC A Y +D
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 54 QNKA--------------RMVRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLA 99
NK +V+ LL AD N G TAL +ACA GG + +LL
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA-GGFVDIVKVLLN 326
Query: 100 HGADPSVRDHAGASALVHALDRGDRETLATLLD 132
GA+ + G + L+ A G E LLD
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLD 359
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/133 (37%), Positives = 65/133 (48%), Gaps = 10/133 (7%)
Query: 3 HTE-GHA-LLRAVGQGKLRLARLLLEGGAYVNEGDAQ-GETALMAACRARYDDPQNKARM 59
H E GH L+ A G + +AR+LL+ GA +N + E+AL AC + D M
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD------M 387
Query: 60 VRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHAL 119
VR+LLE GAD TALM AC G VA LLL GA ++ + S L A
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACM-DGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446
Query: 120 DRGDRETLATLLD 132
G E A L++
Sbjct: 447 CGGHVELAALLIE 459
Score = 49.7 bits (117), Expect = 6e-06
Identities = 46/128 (35%), Positives = 63/128 (49%), Gaps = 12/128 (9%)
Query: 5 EGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLL 64
E L A G G + LA LL+E GA + E + +G T LM A R +++ MV LL
Sbjct: 439 ESPLTLAACG-GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEE------MVALLL 491
Query: 65 EQGADPNI-ADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGD 123
QGA+ N + TAL AC GG + VA L+ GAD + ++ L+ A G
Sbjct: 492 AQGANINAQTEETQETALTLACC-GGFSEVADFLIKAGADIEL---GCSTPLMEASQEGH 547
Query: 124 RETLATLL 131
E + LL
Sbjct: 548 LELVKYLL 555
Score = 46.6 bits (109), Expect = 5e-05
Identities = 72/335 (21%), Positives = 132/335 (39%), Gaps = 26/335 (7%)
Query: 9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQG--ETAL-MAACRARYDDPQNKARMVRYLLE 65
L+ A G + R+LL+ GA VN +TAL +AA + Y + L+
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY-------KFCELLIH 1313
Query: 66 QGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRE 125
+GA ++ ++ G T L A + GG V LL+ GAD D+ + L+ A +G +
Sbjct: 1314 RGAHIDVRNKKGNTPLWLA-SNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVK 1372
Query: 126 TLATLLDACKAKGTEV---IIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCT 182
+ L+ +++ I T T KK Q + + + A A+ +
Sbjct: 1373 VVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILL 1432
Query: 183 SPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPL 242
+++ + + + R + +E+++ E K +D E PK P+
Sbjct: 1433 KELDLEKSREESRKQALAAKREKRKEKRKKKKEEQKRKQEED---EENKPKENSELPEDE 1489
Query: 243 -KRLNSEPWGLVAPPQPVPPTEGRP-GIERLTAEFNGL------TLTGRPRLSRRHSTEG 294
+ N E P +P T GI +A F + + P +R++
Sbjct: 1490 DEEENDEDVEQEVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNK 1549
Query: 295 PEDPPPWAEKVTSGGPLS-RRNTAPEAQESGPPSG 328
++ PP A + +S + A + + +G P G
Sbjct: 1550 TKETPPTAHLILPEQHMSLAQQKADKNKINGEPRG 1584
Score = 43.5 bits (101), Expect = 4e-04
Identities = 45/134 (33%), Positives = 64/134 (47%), Gaps = 13/134 (9%)
Query: 2 LHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETAL-MAACRARYDDPQNKARMV 60
+HT AL+ A G + +ARLLL+ GA VN E+ L +AAC + +
Sbjct: 405 MHT---ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE-------LA 454
Query: 61 RYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVR-DHAGASALVHAL 119
L+E+GA+ + G T LM A G VA LLLA GA+ + + + +AL A
Sbjct: 455 ALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA-LLLAQGANINAQTEETQETALTLAC 513
Query: 120 DRGDRETLATLLDA 133
G E L+ A
Sbjct: 514 CGGFSEVADFLIKA 527
Score = 43.5 bits (101), Expect = 4e-04
Identities = 50/164 (30%), Positives = 64/164 (39%), Gaps = 33/164 (20%)
Query: 12 AVGQGKLRLARLLLEGGAYVNE--GDAQGETALMAACRARYDDPQNKARMVRYLLEQGAD 69
A G + + ++LL GA +N G G + LM A V+ LL+ G+D
Sbjct: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM------NGHVPAVKLLLDMGSD 1215
Query: 70 PNIADRLGR-TALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLA 128
N R TAL AC G A V SLLL A+ R G + L+ A G E
Sbjct: 1216 INAQIETNRNTALTLACF-QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1274
Query: 129 TLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPA 172
LLD KG +V N+PP P D A
Sbjct: 1275 VLLD----KGADV-------------------NAPPVPSSRDTA 1295
Score = 41.2 bits (95), Expect = 0.002
Identities = 41/131 (31%), Positives = 58/131 (44%), Gaps = 8/131 (6%)
Query: 4 TEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYL 63
T AL A G + + ++LL GA + + + G T LM A A + + R L
Sbjct: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGH------VEVARVL 357
Query: 64 LEQGADPNI-ADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRG 122
L+ GA N ++ +AL AC G V LL A GAD + +AL+ A G
Sbjct: 358 LDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA-GADQEHKTDEMHTALMEACMDG 416
Query: 123 DRETLATLLDA 133
E LLD+
Sbjct: 417 HVEVARLLLDS 427
Score = 41.2 bits (95), Expect = 0.002
Identities = 42/135 (31%), Positives = 61/135 (45%), Gaps = 11/135 (8%)
Query: 3 HTEGH---ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARM 59
HTE + AL A G L +L+ A + D +G T L+ A A + +
Sbjct: 1050 HTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGH------VGV 1103
Query: 60 VRYLLEQGADPNI-ADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHA 118
V LL++G D ++R T L AC+GG V LLLA GA+ R+ + + L A
Sbjct: 1104 VEILLDKGGDIEAQSERTKDTPLSLACSGGR-QEVVDLLLARGANKEHRNVSDYTPLSLA 1162
Query: 119 LDRGDRETLATLLDA 133
G + LL+A
Sbjct: 1163 ASGGYVNIIKILLNA 1177
Score = 36.2 bits (82), Expect = 0.071
Identities = 29/98 (29%), Positives = 44/98 (44%), Gaps = 6/98 (6%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A +G + LL+ GA+++ + +G T L A + D +V+ L++ G
Sbjct: 1295 ALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFD------VVQLLVQAG 1348
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPS 105
AD + AD T LM A G V L+ PS
Sbjct: 1349 ADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPS 1386
Score = 30.8 bits (68), Expect = 3.0
Identities = 63/274 (22%), Positives = 95/274 (34%), Gaps = 49/274 (17%)
Query: 148 TSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRAQEE 207
+SP+ T Q P S V D +P S + P+ + L SPR
Sbjct: 2068 SSPTPTSSNTQEEAQPSS--VSDLSPMSMPFASNSEPAPLTLT----------SPR-MVA 2114
Query: 208 EEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGL-VAPPQPVPPTEGRP 266
+ +D P P P+ + P ++ +P + V P + P +G P
Sbjct: 2115 ADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIFVTNPVTLTPPQGPP 2174
Query: 267 GIERLTAE---FNGLTLTGRPRLSRRHSTEGP-----------EDPPPWAEKVTSGGPLS 312
+L++ NG + P T GP + A + GPLS
Sbjct: 2175 AAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSSQVPANQGWGDGPLS 2234
Query: 313 RR---NTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPL 369
R + + Q + + + L M P PG P +R S SP+
Sbjct: 2235 SRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPS-----------QRVSTSPV 2283
Query: 370 TLP---PAGSAPS----PRQSQESLPGAVSPLSG 396
LP P+GS+PS P S +PG L G
Sbjct: 2284 GLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQG 2317
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 62.4 bits (150), Expect = 9e-10
Identities = 52/152 (34%), Positives = 68/152 (44%), Gaps = 29/152 (19%)
Query: 9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDD---------------- 52
L+ A +G L L + LL GA V+ A G+TAL AC + D
Sbjct: 568 LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 627
Query: 53 -----PQNKAR------MVRYLLEQGADPN-IADRLGRTALMHACAGGGGAAVASLLLAH 100
P KA V++L+ +GA+ N T L ACA GG AV LLLAH
Sbjct: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACA-GGHLAVVELLLAH 686
Query: 101 GADPSVRDHAGASALVHALDRGDRETLATLLD 132
GADP+ R G++ L+ A G + LLD
Sbjct: 687 GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 56.6 bits (135), Expect = 5e-08
Identities = 42/132 (31%), Positives = 63/132 (47%), Gaps = 10/132 (7%)
Query: 4 TEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYL 63
++ +L A +G + R LL G VNE +GE+ L AC A Y + + + L
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYE------LAQVL 286
Query: 64 LEQGADPNIADR--LGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDR 121
L A N+ DR G + A A GG + LLLAH AD + + G +AL +A
Sbjct: 287 LAMHA--NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344
Query: 122 GDRETLATLLDA 133
G + + LL++
Sbjct: 345 GYVDVVKVLLES 356
Score = 55.8 bits (133), Expect = 9e-08
Identities = 51/133 (38%), Positives = 64/133 (48%), Gaps = 10/133 (7%)
Query: 3 HTE-GHA-LLRAVGQGKLRLARLLLEGGAYVNEGDAQ-GETALMAACRARYDDPQNKARM 59
H E GH L+ A G + +ARLLLE GA +N + E+AL AC + M
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACY------KGHLEM 416
Query: 60 VRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHAL 119
VR+LLE GAD TALM AC G VA LLL GA ++ + S L A
Sbjct: 417 VRFLLEAGADQEHKTDEMHTALMEACM-DGHVEVARLLLDSGAQVNMPADSFESPLTLAA 475
Query: 120 DRGDRETLATLLD 132
G E A L++
Sbjct: 476 CGGHVELAALLIE 488
Score = 48.1 bits (113), Expect = 2e-05
Identities = 48/159 (30%), Positives = 64/159 (40%), Gaps = 37/159 (23%)
Query: 5 EGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLL 64
E L A G G + LA LL+E GA + E + +G T LM A R +++ MV LL
Sbjct: 468 ESPLTLAACG-GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEE------MVALLL 520
Query: 65 EQGADPNI-ADRLGRTALMHACAGG-----------------------------GGAAVA 94
QGA+ N + TAL AC GG G +
Sbjct: 521 GQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELV 580
Query: 95 SLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDA 133
LLA GA+ G +AL +A + G + LL A
Sbjct: 581 KYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQA 619
Score = 46.2 bits (108), Expect = 7e-05
Identities = 43/127 (33%), Positives = 59/127 (46%), Gaps = 8/127 (6%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A G L + LLE GA + D +G T L+ A A + +V LL+ G
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH------VGVVEILLDNG 1139
Query: 68 ADPNI-ADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRET 126
AD ++R T L AC+GG V LLLA GA+ R+ + + L A G
Sbjct: 1140 ADIEAQSERTKDTPLSLACSGGR-QEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNI 1198
Query: 127 LATLLDA 133
+ LL+A
Sbjct: 1199 IKILLNA 1205
Score = 42.4 bits (98), Expect = 0.001
Identities = 49/164 (29%), Positives = 63/164 (38%), Gaps = 33/164 (20%)
Query: 12 AVGQGKLRLARLLLEGGAYVNE--GDAQGETALMAACRARYDDPQNKARMVRYLLEQGAD 69
A G + + ++LL GA +N G G + LM A V+ LL+ G+D
Sbjct: 1190 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM------NGHTAAVKLLLDMGSD 1243
Query: 70 PNIADRLGR-TALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLA 128
N R TAL AC G V SLLL A+ R G + L+ A G E
Sbjct: 1244 INAQIETNRNTALTLACF-QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1302
Query: 129 TLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPA 172
LLD KG +V N+PP P D A
Sbjct: 1303 VLLD----KGADV-------------------NAPPVPSSRDTA 1323
Score = 41.2 bits (95), Expect = 0.002
Identities = 37/103 (35%), Positives = 50/103 (48%), Gaps = 12/103 (11%)
Query: 2 LHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETAL-MAACRARYDDPQNKARMV 60
+HT AL+ A G + +ARLLL+ GA VN E+ L +AAC + +
Sbjct: 434 MHT---ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE-------LA 483
Query: 61 RYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGAD 103
L+E+GA + G T LM A G VA LLL GA+
Sbjct: 484 ALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA-LLLGQGAN 525
Score = 41.2 bits (95), Expect = 0.002
Identities = 39/127 (30%), Positives = 53/127 (41%), Gaps = 7/127 (5%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A QG+ + LLL+ A V G T LM A Y A + R LL++G
Sbjct: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY------AEVGRVLLDKG 1308
Query: 68 ADPNIAD-RLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRET 126
AD N R + A G LL+ GA VR+ G + L A + G +
Sbjct: 1309 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDV 1368
Query: 127 LATLLDA 133
+ L+ A
Sbjct: 1369 VQLLVQA 1375
Score = 40.8 bits (94), Expect = 0.003
Identities = 81/404 (20%), Positives = 148/404 (36%), Gaps = 40/404 (9%)
Query: 9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQG--ETAL-MAACRARYDDPQNKARMVRYLLE 65
L+ A G + R+LL+ GA VN +TAL +AA + Y + L+
Sbjct: 1289 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY-------KFCELLIG 1341
Query: 66 QGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRE 125
+GA ++ ++ G T L A A GG V LL+ GAD D+ + L+ A +G +
Sbjct: 1342 RGAHIDVRNKKGNTPLWLA-ANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVK 1400
Query: 126 TLATLLDACKAKGTE---VIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCT 182
+ L+ ++ + I T T KK + S A A+ +
Sbjct: 1401 VVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILL 1460
Query: 183 SPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPL 242
+++ + + R + +E++R E K + + ++ + K
Sbjct: 1461 EELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEK 1520
Query: 243 KRLNSEPWGLVAPPQPVPPTEGRPGIERLTAEF--------NGLTLTGRPRLSRRHSTEG 294
++ EP L PP T GI N +T T R +R++
Sbjct: 1521 LKVEDEPEVLTEPPSATTTT--TIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKI-- 1576
Query: 295 PEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPES 354
P ++ PL + PE S + + + + + C D +
Sbjct: 1577 ----TPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISS----CSDESSN 1628
Query: 355 SRLSLERRRYSASPLTL------PPAGSAPSPRQSQESLPGAVS 392
S S + +S + +T P+ P++ ++S+ G S
Sbjct: 1629 SNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKAS 1672
Score = 35.0 bits (79), Expect = 0.16
Identities = 29/98 (29%), Positives = 44/98 (44%), Gaps = 6/98 (6%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A +G + LL+ GA+++ + +G T L A + D +V+ L++ G
Sbjct: 1323 ALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD------VVQLLVQAG 1376
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPS 105
AD + AD T LM A G V L+ PS
Sbjct: 1377 ADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS 1414
Score = 30.0 bits (66), Expect = 5.1
Identities = 22/54 (40%), Positives = 26/54 (48%), Gaps = 1/54 (1%)
Query: 79 TALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLD 132
TAL ACAGG V + LL GA RD G + L+ A G + LLD
Sbjct: 1085 TALTLACAGGHEELVQT-LLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 1137
Score = 29.3 bits (64), Expect = 8.6
Identities = 33/137 (24%), Positives = 47/137 (34%), Gaps = 28/137 (20%)
Query: 145 TTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLSPRA 204
T T P T K ++SP SP PA P SP + G ++ +
Sbjct: 2025 TNATYPMPTAKEHYPVSSPSSPS----PPAQPGGVSRNSPLD-----CGSASPNKVASSS 2075
Query: 205 QEEEEKRDVFEFPLPKPPDDPS-------------PSEPLPKPPRHP------PKPLKRL 245
++E V E +PP+ S P + + PR P P P R+
Sbjct: 2076 EQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRM 2135
Query: 246 NSEPWGLVAPPQPVPPT 262
P + P VP T
Sbjct: 2136 TVPPLATSSAPVAVPST 2152
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 61.2 bits (147), Expect = 2e-09
Identities = 44/130 (33%), Positives = 70/130 (53%), Gaps = 10/130 (7%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A QG +++ +LL+E GA V+ QG TAL A + + D +V+ LLE G
Sbjct: 1015 ALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHID------VVQVLLEHG 1068
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETL 127
ADPN AD+ GRTA M A G + + LL +GA + + + VH +++ ++L
Sbjct: 1069 ADPNHADQFGRTA-MRVAAKNGHSQIIKLLEKYGASSL---NGCSPSPVHTMEQKPLQSL 1124
Query: 128 ATLLDACKAK 137
++ + + K
Sbjct: 1125 SSKVQSLTIK 1134
Score = 58.9 bits (141), Expect = 1e-08
Identities = 43/118 (36%), Positives = 57/118 (48%), Gaps = 7/118 (5%)
Query: 15 QGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQGADPNIAD 74
+ +L +A LE GA V DA+G TAL +C Q MV+ L+ AD N AD
Sbjct: 956 ENQLTMAEYFLENGANVEASDAEGRTALHVSCW------QGHMEMVQVLIAYHADVNAAD 1009
Query: 75 RLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLD 132
R+AL A A G V LL+ HGA + GA+AL A G + + LL+
Sbjct: 1010 NEKRSALQSA-AWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLE 1066
Score = 58.2 bits (139), Expect = 2e-08
Identities = 46/128 (35%), Positives = 62/128 (48%), Gaps = 8/128 (6%)
Query: 6 GHA-LLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLL 64
GH L A QG ++ L+ GA +N D G TAL +A + + +V LL
Sbjct: 578 GHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTE------VVSALL 631
Query: 65 EQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDR 124
G + AD RTAL A A GG + LL HGA+ + D+ G +AL+ A G R
Sbjct: 632 YAGVKVDCADADSRTAL-RAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHR 690
Query: 125 ETLATLLD 132
E + LLD
Sbjct: 691 EIVEHLLD 698
Score = 55.8 bits (133), Expect = 9e-08
Identities = 46/129 (35%), Positives = 65/129 (50%), Gaps = 10/129 (7%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A G + LL+ GA VN+ D +G TAL+AA + + +V +LL+ G
Sbjct: 647 ALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHRE------IVEHLLDHG 700
Query: 68 ADPNIADRLGRTALMHAC----AGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGD 123
A+ N D GRTAL A A G A+V SLL+ GA+ D G + L+ A G
Sbjct: 701 AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGH 760
Query: 124 RETLATLLD 132
+ + LL+
Sbjct: 761 VDVVDLLLE 769
Score = 53.1 bits (126), Expect = 6e-07
Identities = 46/124 (37%), Positives = 57/124 (45%), Gaps = 7/124 (5%)
Query: 9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQGA 68
LL A +G + + LLLEGGA V+ D G T L+AA A +V LL GA
Sbjct: 752 LLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA------SMGHASVVNTLLFWGA 805
Query: 69 DPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLA 128
+ D GRT L A A G V LL G D + RD AG + L A G R
Sbjct: 806 AVDSIDSEGRTVLSIASA-QGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICE 864
Query: 129 TLLD 132
L++
Sbjct: 865 ALIE 868
Score = 51.2 bits (121), Expect = 2e-06
Identities = 40/126 (31%), Positives = 58/126 (46%), Gaps = 7/126 (5%)
Query: 7 HALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQ 66
+AL A +G + LL GA VN DA G L +N+ M Y LE
Sbjct: 915 NALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILAL------ENQLTMAEYFLEN 968
Query: 67 GADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRET 126
GA+ +D GRTAL H G + +L+A+ AD + D+ SAL A +G +
Sbjct: 969 GANVEASDAEGRTAL-HVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKV 1027
Query: 127 LATLLD 132
+ L++
Sbjct: 1028 VQLLIE 1033
Score = 45.8 bits (107), Expect = 9e-05
Identities = 40/112 (35%), Positives = 54/112 (48%), Gaps = 7/112 (6%)
Query: 22 RLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQGADPNIADRLGRTAL 81
R LL+ GA VN+ D+ G T L A + D +V L+ +GAD I D G T L
Sbjct: 529 RTLLDNGASVNQCDSNGRTLLANAAYSGSLD------VVNLLVSRGADLEIEDAHGHTPL 582
Query: 82 MHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDA 133
A A G V + L+ GA+ + D G +AL A G E ++ LL A
Sbjct: 583 TLA-ARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYA 633
Score = 35.8 bits (81), Expect = 0.092
Identities = 32/105 (30%), Positives = 46/105 (43%), Gaps = 9/105 (8%)
Query: 12 AVGQGKLRLARLLLEGGAYVNEGDAQGETA-LMAACRARYDDPQNKARMVRYLLEQGADP 70
A +G + L+E GA NE D G ++A+ YD V+ LLE ++
Sbjct: 854 AAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYD-------CVQILLENKSNI 906
Query: 71 NIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASAL 115
+ GR AL A G + LL +HGAD + +D G L
Sbjct: 907 DQRGYDGRNAL-RVAALEGHRDIVELLFSHGADVNCKDADGRPTL 950
>gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain
containing 1 [Homo sapiens]
Length = 475
Score = 60.5 bits (145), Expect = 3e-09
Identities = 45/125 (36%), Positives = 67/125 (53%), Gaps = 5/125 (4%)
Query: 9 LLRAVGQGKLRLARLLLEGGAYVN-EGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
L+ A L R+LL+ GA + E D Q + L+ AC A + Q + V LL +
Sbjct: 83 LMYAASVANAELVRVLLDRGANASFEKDKQ--SILITACSAHGSEEQI-LKCVELLLSRN 139
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETL 127
ADPN+A R T +M+A A G V +LL+AHGA+ + +D G +AL A +G + +
Sbjct: 140 ADPNVACRRLMTPIMYA-ARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIV 198
Query: 128 ATLLD 132
LL+
Sbjct: 199 LKLLE 203
>gi|7657265 fem-1 homolog b [Homo sapiens]
Length = 627
Score = 60.5 bits (145), Expect = 3e-09
Identities = 44/124 (35%), Positives = 63/124 (50%), Gaps = 7/124 (5%)
Query: 8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQG 67
AL A G G + +LL+ GA VN T L AAC +D + +V+YL+E
Sbjct: 91 ALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAAC---FD---GRLDIVKYLVENN 144
Query: 68 ADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETL 127
A+ +IA++ T LM A A G V LL ADP+ + H GA+AL A + G + +
Sbjct: 145 ANISIANKYDNTCLMIA-AYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIV 203
Query: 128 ATLL 131
L+
Sbjct: 204 KELI 207
Score = 46.2 bits (108), Expect = 7e-05
Identities = 42/144 (29%), Positives = 58/144 (40%), Gaps = 20/144 (13%)
Query: 4 TEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYL 63
T L A G+L + + L+E A ++ + T LM A + D +VRYL
Sbjct: 120 TNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTD------VVRYL 173
Query: 64 LEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGD 123
LEQ ADPN G TAL H A G + L+ A V H V A
Sbjct: 174 LEQRADPNAKAHCGATAL-HFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAA----- 227
Query: 124 RETLATLLDACKAKGTEVIIITTD 147
++CKA E+++ D
Sbjct: 228 --------ESCKADVVELLLSHAD 243
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 58.2 bits (139), Expect = 2e-08
Identities = 84/333 (25%), Positives = 115/333 (34%), Gaps = 48/333 (14%)
Query: 137 KGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAP----ASPSPGFCTSPSEIQLQTA 192
KG T SP G T +P +P P+P A+P P +P +
Sbjct: 1215 KGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSL 1274
Query: 193 GGGGRGMLSPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPP-RHPPKPLKRLNS-EPW 250
GG L+ + V P PK SP + P PP PP P + P
Sbjct: 1275 KGG----LATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPK 1330
Query: 251 GLVAPPQPVPPT-EGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGG 309
G PP PP+ +G P + T G T S EGP PP A GG
Sbjct: 1331 GAPTPPAVTPPSPKGTPTLPATTPSSKGGPTT-------PSSKEGP--TPPAATPSHKGG 1381
Query: 310 PLSRRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLERRRYSASPL 369
P P + + GP + P T + P SP+ + + R +A+P
Sbjct: 1382 PA----MTPPSPKRGP--------AIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATP- 1428
Query: 370 TLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLN 429
+ P AV+P+S +++P +G T P PP
Sbjct: 1429 ------------SKGDLTPPAVTPVS-LKKAPATSAPKGGPATPSSKGDPTLPAVTPPSP 1475
Query: 430 VSPHPPIPDIRPQPGGRAPSLPAPPYAGAPGSP 462
P P +AP+ PAP GAP P
Sbjct: 1476 KEPPAPKQVATSSSPKKAPATPAP--MGAPTLP 1506
Score = 52.4 bits (124), Expect = 1e-06
Identities = 87/351 (24%), Positives = 120/351 (34%), Gaps = 40/351 (11%)
Query: 145 TTDTSPSGT---KKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGGRGMLS 201
T D+ S T K T YL PSP +P + P T T G +S
Sbjct: 772 TEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPP--TKKGSAGPDTPIGNLSSPVS 829
Query: 202 P-RAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVP 260
P A E F+ P SP+ P PK P P P G+ PP+ P
Sbjct: 830 PVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGA---PTPSAVTPLSPKGVTLPPKETP 886
Query: 261 ---------PTEG--------RPGIERLTAEFNGLTLTGRPR-LSRRHSTEGPEDPPPWA 302
P EG P + ++ T P+ + S +G PP
Sbjct: 887 TPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAAT 946
Query: 303 EKVTSGGPLS-RRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLER 361
GGP + AP + PPS + + P TP P SP+ +
Sbjct: 947 PPSPKGGPATPSPKWAPTPPAATPPSP-KGGPATPSPKGAPTPPAATPPSPKGGPATPSP 1005
Query: 362 RRYSASPLTLPPA---GSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHIS 418
+ P PP+ A +P S P A +P S + +G+ T +
Sbjct: 1006 KGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLP 1065
Query: 419 QTRPG-FLPPLNVSPHPPIPDIRPQPGGRAPSLPAP-----PYAGAPGSPR 463
+ G P L +P PP P P G P+ P+P P A P SP+
Sbjct: 1066 SPKGGPATPSLKGAPTPPAA-TPPSPKG-GPATPSPKGAPMPPAATPPSPK 1114
Score = 49.3 bits (116), Expect = 8e-06
Identities = 90/366 (24%), Positives = 117/366 (31%), Gaps = 55/366 (15%)
Query: 137 KGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAP-----ASPSP-GFCTSPSEIQLQ 190
KG T SP G T +P P V P+P A+P P G T P+
Sbjct: 983 KGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPS 1042
Query: 191 TAGGGGRGML------SPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPK-------PPRH 237
G L +P A K L P P+ + P PK P
Sbjct: 1043 PKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGA 1102
Query: 238 PPKPLKRLNSEPWGLVAPPQ---PVPPTEGRPGIERLTAEFNGLTLTGRPRLSRRHSTEG 294
P P S GL PP P P P + A P + G
Sbjct: 1103 PMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGG 1162
Query: 295 PEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPES 354
PPP G P T P A P GL + P TP P SP+
Sbjct: 1163 LATPPP------KGAP-----TTPAATPPSPKGGLATPSPKGAPT---TPA-ATPPSPKG 1207
Query: 355 SRLSLERRRYSASPLTLPPAG----SAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSG 410
+ + +P PP+ + PSP+ + P A P + P +G+
Sbjct: 1208 GLATPSPKGAPTTPAATPPSPKGGLATPSPK-GAPTTPAATPP--SPKGGPATPPPKGAP 1264
Query: 411 TLLLDHISQTRPGF-LPPLNVSPHPPIPDIRPQPGGRAPS----LPAPPYA------GAP 459
T + G PP +P+P + GG A S P PP A G+P
Sbjct: 1265 TPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSP 1324
Query: 460 GSPRTK 465
G+P K
Sbjct: 1325 GTPPPK 1330
Score = 47.4 bits (111), Expect = 3e-05
Identities = 80/354 (22%), Positives = 119/354 (33%), Gaps = 48/354 (13%)
Query: 137 KGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPGFCTSPSEIQLQTAGGGG 196
KG T SP G+ T +P P V P+P T+PS T
Sbjct: 1307 KGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSK 1366
Query: 197 RGMLSPRAQEEEEKRDVFEFPLPK-------PPDDPSPSEPLP-KPPRHPPKPLKR--LN 246
G P A + P PK P DP+ +P P + P P+ R
Sbjct: 1367 EGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAA 1426
Query: 247 SEPWGLVAPPQPVPPT-EGRPGIERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKV 305
+ G + PP P + + P + G P L + P++PP +
Sbjct: 1427 TPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLP-AVTPPSPKEPPAPKQVA 1485
Query: 306 TSGGPLSR--------RNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRL 357
TS P T P S P SR +P+ +P ++ L
Sbjct: 1486 TSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPI-----------APTATLL 1534
Query: 358 SLER-RRYSASPLTLPPAGSAPSPRQSQESLP----GAVSPLSGRRRSPGLLERRGSGTL 412
S + + +PPA + PSP+++ ++P +P S SP +
Sbjct: 1535 SKKTPATLAPKEALIPPAMTVPSPKKT-PAIPTPKEAPATPSSKEASSPPAVT-----PS 1588
Query: 413 LLDHISQTRPGFLPPLNVSPH----PPIPDIRPQPGGRAPSLPAPPYAGAPGSP 462
+ +PP SP P P + P + P+ PAP G P SP
Sbjct: 1589 TYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAP--KGTPTSP 1640
Score = 36.2 bits (82), Expect = 0.071
Identities = 65/270 (24%), Positives = 93/270 (34%), Gaps = 49/270 (18%)
Query: 165 SPGVEDP--APASPSPGFCTSPSEIQLQTAGGGG--RGMLSPRAQEEEEKRDVFEFPLPK 220
+P + P APA+PS +SP + T G + +L P A ++ P
Sbjct: 1561 TPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVT 1620
Query: 221 PPD-DPSPSEPLPK-PPRHPPKPLKRLNSEP---------WGLVAPP--QPVPPTEGRPG 267
PP + P+ P PK P PP L P G P + +P +G
Sbjct: 1621 PPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTA 1680
Query: 268 IERL--------TAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPE 319
++ + T T G P+ + +T P P P A K S GPLS AP
Sbjct: 1681 LKEVLVAPAPESTPIITAPTRKG-PQTKKSSATSPPICPDPSA-KNGSKGPLSTVAPAPL 1738
Query: 320 AQESGPPSGLRQKLSRMEPVELDTPGHLCPDS------------------PESSRLSLER 361
P K ++ + G L P PES+ +S
Sbjct: 1739 L----PVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAP 1794
Query: 362 RRYSASPLTLPPAGSAPSPRQSQESLPGAV 391
+ PL P + P +Q S PG V
Sbjct: 1795 SPPVSLPLAPSPVPTLPPKQQFLPSSPGLV 1824
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,048,508
Number of Sequences: 37866
Number of extensions: 2022723
Number of successful extensions: 21603
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 446
Number of HSP's successfully gapped in prelim test: 1479
Number of HSP's that attempted gapping in prelim test: 10707
Number of HSP's gapped (non-prelim): 7779
length of query: 496
length of database: 18,247,518
effective HSP length: 106
effective length of query: 390
effective length of database: 14,233,722
effective search space: 5551151580
effective search space used: 5551151580
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.