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Search of human proteins with 8923881
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
(404 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 845 0.0
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 394 e-110
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ... 299 3e-81
gi|16554629 WD repeat domain 5 [Homo sapiens] 121 1e-27
gi|16554627 WD repeat domain 5 [Homo sapiens] 121 1e-27
gi|113865883 WD repeat domain 38 [Homo sapiens] 120 2e-27
gi|32189425 WD repeat domain 69 [Homo sapiens] 100 2e-21
gi|26665869 WD repeat domain 51B [Homo sapiens] 100 2e-21
gi|23199987 WD repeat domain 5B [Homo sapiens] 97 3e-20
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 97 3e-20
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 97 3e-20
gi|21071067 TBP-associated factor 5 [Homo sapiens] 94 2e-19
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 93 4e-19
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 93 4e-19
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 91 2e-18
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 89 5e-18
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 89 9e-18
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 87 4e-17
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 87 4e-17
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 85 1e-16
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 85 1e-16
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 85 1e-16
gi|13376840 WD repeat domain 61 [Homo sapiens] 85 1e-16
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 84 3e-16
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 84 3e-16
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 84 3e-16
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 83 5e-16
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 82 7e-16
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 82 7e-16
gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens] 81 1e-15
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 845 bits (2183), Expect = 0.0
Identities = 404/404 (100%), Positives = 404/404 (100%)
Query: 1 MEAGEEPLLLAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCIVKLIPWPLEEQ 60
MEAGEEPLLLAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCIVKLIPWPLEEQ
Sbjct: 1 MEAGEEPLLLAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCIVKLIPWPLEEQ 60
Query: 61 FIPKGFEAKSRSSKNETKGRGSPKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPD 120
FIPKGFEAKSRSSKNETKGRGSPKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPD
Sbjct: 61 FIPKGFEAKSRSSKNETKGRGSPKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPD 120
Query: 121 VSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRI 180
VSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRI
Sbjct: 121 VSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRI 180
Query: 181 WDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQS 240
WDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQS
Sbjct: 181 WDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQS 240
Query: 241 SVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVC 300
SVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVC
Sbjct: 241 SVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVC 300
Query: 301 FSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 360
FSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW
Sbjct: 301 FSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 360
Query: 361 TAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRTF 404
TAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRTF
Sbjct: 361 TAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRTF 404
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 394 bits (1013), Expect = e-110
Identities = 205/400 (51%), Positives = 260/400 (65%), Gaps = 12/400 (3%)
Query: 13 LKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCIVKLIPWP-LEEQFIPKGFEAKSR 71
L P P FD K E W+VAF+PDGS+FAWSQGH VKL+PW + F+ G + +
Sbjct: 23 LAPAAP--FDKKCGRENWTVAFAPDGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTN 80
Query: 72 SS------KNETKG-RGSPKEKTLDCGQIVWGLAF-SPWPSPPSRKLWARHHPQVPDVSC 123
SS +N G + P+E +DCG IVW LAF S P SR + H
Sbjct: 81 SSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQ 140
Query: 124 LVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDL 183
L+LATGLN+G+IKIW+V TG LLLNL H +VVRDL+F P GSLILVSASRDKTLR+WDL
Sbjct: 141 LLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200
Query: 184 NKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVV 243
G ++VL GH WVY C+ SPD SMLCS K+VFLW+M YT+IRKLEGH VV
Sbjct: 201 KDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVV 260
Query: 244 SCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPA-MDDSDVHISSLRSVCFS 302
+CDFSPD ALL TASYDT V +WDP+ G+ L H P + + +RSV FS
Sbjct: 261 ACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFS 320
Query: 303 PEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTA 362
+GL++A++ADD+++R W ++ P+ AP++NGLCC F G V+A GT DG V FW
Sbjct: 321 HDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWAT 380
Query: 363 PRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
PR + SL+HLCR ++R + T +V LPIP K+ EFL+YR
Sbjct: 381 PRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420
>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
sapiens]
Length = 275
Score = 299 bits (765), Expect = 3e-81
Identities = 143/268 (53%), Positives = 184/268 (68%), Gaps = 1/268 (0%)
Query: 136 KIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSG 195
++ E + G LLLNL H +VVRDL+F P GSLILVSASRDKTLR+WDL G ++VL G
Sbjct: 7 RVNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRG 66
Query: 196 HLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLV 255
H WVY C+ SPD SMLCS K+VFLW+M YT+IRKLEGH VV+CDFSPD ALL
Sbjct: 67 HQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLA 126
Query: 256 TASYDTNVIMWDPYTGERLRSLHHTQVDPA-MDDSDVHISSLRSVCFSPEGLYLATVADD 314
TASYDT V +WDP+ G+ L H P + + +RSV FS +GL++A++ADD
Sbjct: 127 TASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADD 186
Query: 315 RLLRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTAPRVLSSLKHLCR 374
+++R W ++ P+ AP++NGLCC F G V+A GT DG V FW PR + SL+HLCR
Sbjct: 187 KMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCR 246
Query: 375 KALRSFLTTYQVLALPIPKKMKEFLTYR 402
++R + T +V LPIP K+ EFL+YR
Sbjct: 247 MSIRRVMPTQEVQELPIPSKLLEFLSYR 274
Score = 47.4 bits (111), Expect = 2e-05
Identities = 40/137 (29%), Positives = 64/137 (46%), Gaps = 26/137 (18%)
Query: 108 RKLWARHHPQV-----PDVSCLVLATGLNDGQIKIWEVQTGLLLLNL------------- 149
RKL HH V PD + +LAT D ++ IW+ G +L+
Sbjct: 104 RKLEGHHHDVVACDFSPDGA--LLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAG 161
Query: 150 SGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK-HGKQIQVLSGHLQWVYCCSISPD 208
+ VR +SF+ G L + S + DK +R W +++ + Q+ LS L CC+ S D
Sbjct: 162 GANDRWVRSVSFSHDG-LHVASLADDKMVRFWRIDEDYPVQVAPLSNGL----CCAFSTD 216
Query: 209 CSMLCSAAGEKSVFLWS 225
S+L + + SV+ W+
Sbjct: 217 GSVLAAGTHDGSVYFWA 233
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 121 bits (304), Expect = 1e-27
Identities = 76/240 (31%), Positives = 128/240 (53%), Gaps = 18/240 (7%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
LA+ D IKIW G +SGH+ + D++++ S S +LVSAS DKTL+IWD++
Sbjct: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNLLVSASDDKTLKIWDVSS 118
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
GK ++ L GH +V+CC+ +P +++ S + ++SV +W +++ ++ L H V +
Sbjct: 119 -GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV 177
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
F+ D +L+V++SYD +WD +G+ L++L +DD + +S ++ FSP G
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDDNPPVSFVK---FSPNG 226
Query: 306 LYLATVADDRLLRIWALE----LKTPIAFAPMTNGLCCTFFPHGGV-IATGTRDGHVQFW 360
Y+ D L++W LKT + F GG I +G+ D V W
Sbjct: 227 KYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286
Score = 71.2 bits (173), Expect = 2e-12
Identities = 65/290 (22%), Positives = 116/290 (40%), Gaps = 63/290 (21%)
Query: 31 SVAFSPDGSWFAWSQGHCIVKLIPWPLEEQFIPK-------GFEAKSRSSKNETKGRGSP 83
SV FSP+G W A S ++K+ W + K G + SS + S
Sbjct: 50 SVKFSPNGEWLASSSADKLIKI--WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 84 KEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPDVSCLVLATGLNDGQIKIWEVQTG 143
+KTL + G + +PQ ++ +G D ++IW+V+TG
Sbjct: 108 -DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-----LIVSGSFDESVRIWDVKTG 161
Query: 144 LLLLNLSGHQDVVRDLSFTPSGSLI----------------------------------- 168
L L H D V + F GSLI
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 169 -------LVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCS---MLCSAAGE 218
+++A+ D TL++WD +K GK ++ +GH YC + + + S + +
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSK-GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 280
Query: 219 KSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASY--DTNVIMW 266
V++W++++ +++KL+GH V+S P ++ +A+ D + +W
Sbjct: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 57.8 bits (138), Expect = 2e-08
Identities = 43/172 (25%), Positives = 80/172 (46%), Gaps = 18/172 (10%)
Query: 193 LSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSA 252
L+GH + V SP+ L S++ +K + +W + + GH+ + +S DS
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 253 LLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVA 312
LLV+AS D + +WD +G+ L++L H + + F+P+ + + +
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKG------------HSNYVFCCNFNPQSNLIVSGS 148
Query: 313 DDRLLRIWALE----LKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 360
D +RIW ++ LKT A + + + F G +I + + DG + W
Sbjct: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAV--HFNRDGSLIVSSSYDGLCRIW 198
Score = 54.7 bits (130), Expect = 1e-07
Identities = 37/137 (27%), Positives = 61/137 (44%), Gaps = 18/137 (13%)
Query: 228 SYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMD 287
+Y L L GH +V S FSP+ L ++S D + +W Y G+ +++
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI---------- 83
Query: 288 DSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALE----LKTPIAFAPMTNGLCCTFFP 343
H + V +S + L + +DD+ L+IW + LKT + CC F P
Sbjct: 84 --SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV--FCCNFNP 139
Query: 344 HGGVIATGTRDGHVQFW 360
+I +G+ D V+ W
Sbjct: 140 QSNLIVSGSFDESVRIW 156
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 121 bits (304), Expect = 1e-27
Identities = 76/240 (31%), Positives = 128/240 (53%), Gaps = 18/240 (7%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
LA+ D IKIW G +SGH+ + D++++ S S +LVSAS DKTL+IWD++
Sbjct: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNLLVSASDDKTLKIWDVSS 118
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
GK ++ L GH +V+CC+ +P +++ S + ++SV +W +++ ++ L H V +
Sbjct: 119 -GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV 177
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
F+ D +L+V++SYD +WD +G+ L++L +DD + +S ++ FSP G
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDDNPPVSFVK---FSPNG 226
Query: 306 LYLATVADDRLLRIWALE----LKTPIAFAPMTNGLCCTFFPHGGV-IATGTRDGHVQFW 360
Y+ D L++W LKT + F GG I +G+ D V W
Sbjct: 227 KYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286
Score = 71.2 bits (173), Expect = 2e-12
Identities = 65/290 (22%), Positives = 116/290 (40%), Gaps = 63/290 (21%)
Query: 31 SVAFSPDGSWFAWSQGHCIVKLIPWPLEEQFIPK-------GFEAKSRSSKNETKGRGSP 83
SV FSP+G W A S ++K+ W + K G + SS + S
Sbjct: 50 SVKFSPNGEWLASSSADKLIKI--WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 84 KEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPDVSCLVLATGLNDGQIKIWEVQTG 143
+KTL + G + +PQ ++ +G D ++IW+V+TG
Sbjct: 108 -DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-----LIVSGSFDESVRIWDVKTG 161
Query: 144 LLLLNLSGHQDVVRDLSFTPSGSLI----------------------------------- 168
L L H D V + F GSLI
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 169 -------LVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCS---MLCSAAGE 218
+++A+ D TL++WD +K GK ++ +GH YC + + + S + +
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSK-GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 280
Query: 219 KSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASY--DTNVIMW 266
V++W++++ +++KL+GH V+S P ++ +A+ D + +W
Sbjct: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 57.8 bits (138), Expect = 2e-08
Identities = 43/172 (25%), Positives = 80/172 (46%), Gaps = 18/172 (10%)
Query: 193 LSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSA 252
L+GH + V SP+ L S++ +K + +W + + GH+ + +S DS
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 253 LLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVA 312
LLV+AS D + +WD +G+ L++L H + + F+P+ + + +
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKG------------HSNYVFCCNFNPQSNLIVSGS 148
Query: 313 DDRLLRIWALE----LKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 360
D +RIW ++ LKT A + + + F G +I + + DG + W
Sbjct: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAV--HFNRDGSLIVSSSYDGLCRIW 198
Score = 54.7 bits (130), Expect = 1e-07
Identities = 37/137 (27%), Positives = 61/137 (44%), Gaps = 18/137 (13%)
Query: 228 SYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMD 287
+Y L L GH +V S FSP+ L ++S D + +W Y G+ +++
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI---------- 83
Query: 288 DSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALE----LKTPIAFAPMTNGLCCTFFP 343
H + V +S + L + +DD+ L+IW + LKT + CC F P
Sbjct: 84 --SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV--FCCNFNP 139
Query: 344 HGGVIATGTRDGHVQFW 360
+I +G+ D V+ W
Sbjct: 140 QSNLIVSGSFDESVRIW 156
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 120 bits (302), Expect = 2e-27
Identities = 85/266 (31%), Positives = 125/266 (46%), Gaps = 40/266 (15%)
Query: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
+L TG DG + WE ++G LL L GH V+ F+P G L SAS D T+R+WD+
Sbjct: 35 MLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF-ASASCDCTVRLWDVA 93
Query: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
+ K ++VL GH + V S SPD L S +K V LW ++S ++R L GH+ S+ S
Sbjct: 94 R-AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS 152
Query: 245 CDFSPDSALLVTASYDTNVIMWD-----PYTGERLRSLHHTQVD-----------PAMDD 288
DFSP L T S+D+ V +WD P + H + D
Sbjct: 153 SDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWD 212
Query: 289 SDVHI-----SSL-----------RSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAP 332
+HI SSL +S+ FSP+ L+LA+ R++++W + T
Sbjct: 213 KTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW--DCNTGKCLET 270
Query: 333 MTNGL----CCTFFPHGGVIATGTRD 354
+ L C F P G ++ +G D
Sbjct: 271 LKGVLDVAHTCAFTPDGKILVSGAAD 296
Score = 100 bits (248), Expect = 3e-21
Identities = 70/225 (31%), Positives = 107/225 (47%), Gaps = 20/225 (8%)
Query: 152 HQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSM 211
H V +F+P G ++L + S D + W+ + G+ + L GH V C SPD +
Sbjct: 20 HGGEVNSSAFSPDGQMLL-TGSEDGCVYGWE-TRSGQLLWRLGGHTGPVKFCRFSPDGHL 77
Query: 212 LCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTG 271
SA+ + +V LW + +R L+GHQ SV + FSPDS L + +D V++WD +G
Sbjct: 78 FASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG 137
Query: 272 ERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFA 331
+ LR L H S++S FSP LAT + D + IW L + TP
Sbjct: 138 QMLRLLVG------------HRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSH 185
Query: 332 PMTNG----LCCTFFPHGGVIATGTRDGHVQFW--TAPRVLSSLK 370
G + C + G++A+G+ D + W T +L LK
Sbjct: 186 QALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLK 230
Score = 93.2 bits (230), Expect = 4e-19
Identities = 86/316 (27%), Positives = 136/316 (43%), Gaps = 62/316 (19%)
Query: 17 RPHQFDWKSSCETWSVAF---SPDGSWFAWSQGHCIVKLIPWPLEEQFIPKGFEAKSRSS 73
R Q W+ T V F SPDG FA + C V+L W + + + RS
Sbjct: 51 RSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRL--WDVARAKCLRVLKGHQRS- 107
Query: 74 KNETKGRGSPKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPDVSCLVLATGLNDG 133
V ++F SP SR+ LA+G D
Sbjct: 108 --------------------VETVSF----SPDSRQ----------------LASGGWDK 127
Query: 134 QIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQI--Q 191
++ +W+VQ+G +L L GH+D ++ F+P+ + L + S D T+ IWDL + Q
Sbjct: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVN-CLATGSWDSTVHIWDLRMVTPAVSHQ 186
Query: 192 VLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDS 251
L GH + C S +L S + +K++ +W + +L+ +L+GH + V S FSPD
Sbjct: 187 ALEGHSANISCLCYSAS-GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
Query: 252 ALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATV 311
L +A Y V +WD TG+ L +L + + F+P+G L +
Sbjct: 246 LWLASAGYSRMVKVWDCNTGKCLETLKGV------------LDVAHTCAFTPDGKILVSG 293
Query: 312 ADDRLLRIWALELKTP 327
A D+ R + K+P
Sbjct: 294 AADQTRRQISRTSKSP 309
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 100 bits (250), Expect = 2e-21
Identities = 65/245 (26%), Positives = 112/245 (45%), Gaps = 30/245 (12%)
Query: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
++ATG D K+W++Q G + L GH + LSF SG I ++ S D T+ +WD +
Sbjct: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRI-ITGSFDHTVVVWDAD 249
Query: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
G+++ +L GH + S + DCS++ + + +K+ LW + + L GH ++
Sbjct: 250 T-GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILD 308
Query: 245 CDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPE 304
F L+ TAS D ++ T + + L + H + + F+P+
Sbjct: 309 SCFDYTGKLIATASADGTARIFSAATRKCIAKL------------EGHEGEISKISFNPQ 356
Query: 305 GLYLATVADDRLLRIW---------ALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDG 355
G +L T + D+ RIW LE T F+ C F G ++ TG++D
Sbjct: 357 GNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFS-------CAFNYKGNIVITGSKDN 409
Query: 356 HVQFW 360
+ W
Sbjct: 410 TCRIW 414
Score = 95.5 bits (236), Expect = 8e-20
Identities = 66/273 (24%), Positives = 116/273 (42%), Gaps = 35/273 (12%)
Query: 122 SCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIW 181
SC + TG D K+W+ +G L L GH++VV ++F + + S DKT ++W
Sbjct: 105 SCFI--TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162
Query: 182 DLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSS 241
+ GK GH + C S +P +++ + + + + LW +++ + L GH +
Sbjct: 163 SVET-GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAE 221
Query: 242 VVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSL--HHTQVDPAMDDSDV-------- 291
++S F+ ++T S+D V++WD TG ++ L H ++ A + D
Sbjct: 222 IISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSM 281
Query: 292 --------------------HISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFA 331
H + CF G +AT + D RI++ + IA
Sbjct: 282 DKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKL 341
Query: 332 PMTNGLC--CTFFPHGGVIATGTRDGHVQFWTA 362
G +F P G + TG+ D + W A
Sbjct: 342 EGHEGEISKISFNPQGNHLLTGSSDKTARIWDA 374
Score = 75.1 bits (183), Expect = 1e-13
Identities = 43/144 (29%), Positives = 71/144 (49%), Gaps = 2/144 (1%)
Query: 123 CLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWD 182
C ++ TG D K+W+ G + L+GH D + D F +G LI +AS D T RI+
Sbjct: 273 CSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLI-ATASADGTARIFS 331
Query: 183 LNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSV 242
K I L GH + S +P + L + + +K+ +W ++ ++ LEGH +
Sbjct: 332 AATR-KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEI 390
Query: 243 VSCDFSPDSALLVTASYDTNVIMW 266
SC F+ +++T S D +W
Sbjct: 391 FSCAFNYKGNIVITGSKDNTCRIW 414
Score = 60.5 bits (145), Expect = 3e-09
Identities = 31/105 (29%), Positives = 58/105 (55%), Gaps = 2/105 (1%)
Query: 120 DVSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLR 179
D + ++AT DG +I+ T + L GH+ + +SF P G+ +L +S DKT R
Sbjct: 312 DYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSS-DKTAR 370
Query: 180 IWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLW 224
IWD + G+ +QVL GH ++ C+ + +++ + + + + +W
Sbjct: 371 IWDA-QTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 48.9 bits (115), Expect = 8e-06
Identities = 34/139 (24%), Positives = 65/139 (46%), Gaps = 15/139 (10%)
Query: 225 SMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDP 284
S ++ L + L+ H + + + + +T SYD +WD +GE L +L
Sbjct: 78 SNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTL------- 130
Query: 285 AMDDSDVHISSLRSVCF-SPEGLYLATVADDRLLRIWALEL-KTPIAFAPMTNGL-CCTF 341
+ H + + ++ F +P G +AT + D+ ++W++E K F T + C +F
Sbjct: 131 -----EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSF 185
Query: 342 FPHGGVIATGTRDGHVQFW 360
P ++ATG+ D + W
Sbjct: 186 NPQSTLVATGSMDTTAKLW 204
Score = 42.7 bits (99), Expect = 6e-04
Identities = 38/175 (21%), Positives = 74/175 (42%), Gaps = 15/175 (8%)
Query: 191 QVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDF-SP 249
+VL H+ + +++ S + + +++ LW S + LEGH++ V + F +P
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 250 DSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLA 309
+ T S+D +W TG+ +HT H + + + F+P+ +A
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGK----CYHT--------FRGHTAEIVCLSFNPQSTLVA 193
Query: 310 TVADDRLLRIWALELKTPI--AFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTA 362
T + D ++W ++ + + +F G I TG+ D V W A
Sbjct: 194 TGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA 248
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 100 bits (250), Expect = 2e-21
Identities = 66/232 (28%), Positives = 106/232 (45%), Gaps = 16/232 (6%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
LAT D + +W + GH+DVV + F+P G+L L SASRD+T+R+W +K
Sbjct: 33 LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL-LASASRDRTVRLWIPDK 91
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
GK H V S D L +A+ +KS+ +WSM + L H V
Sbjct: 92 RGK-FSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCA 150
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
FSPD L+V+ S D + +WD T +++ + V F+P G
Sbjct: 151 KFSPDGRLIVSCSEDKTIKIWD------------TTNKQCVNNFSDSVGFANFVDFNPSG 198
Query: 306 LYLATVADDRLLRIWALELKTPIAFAPMTNG--LCCTFFPHGGVIATGTRDG 355
+A+ D+ +++W + + + + +G C +F P G + T + DG
Sbjct: 199 TCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDG 250
Score = 85.5 bits (210), Expect = 8e-17
Identities = 63/223 (28%), Positives = 100/223 (44%), Gaps = 17/223 (7%)
Query: 151 GHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCS 210
GH+ + L +P+G L +AS D L +W+ H + + + GH V SP +
Sbjct: 16 GHKAAITSLDLSPNGKQ-LATASWDTFLMLWNFKPHARAYRYV-GHKDVVTSVQFSPHGN 73
Query: 211 MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYT 270
+L SA+ +++V LW + + H + V S DFS D L TAS D ++ +W Y
Sbjct: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
Query: 271 GERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAF 330
L SL+ H +R FSP+G + + ++D+ ++IW K +
Sbjct: 134 QRFLYSLYR------------HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
Query: 331 APMTNGLC--CTFFPHGGVIATGTRDGHVQFWTAPRVLSSLKH 371
+ G F P G IA+ D V+ W RV L+H
Sbjct: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV-RVNKLLQH 223
Score = 75.1 bits (183), Expect = 1e-13
Identities = 54/195 (27%), Positives = 86/195 (44%), Gaps = 14/195 (7%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
LAT D IK+W + L +L H VR F+P G LI VS S DKT++IWD
Sbjct: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLI-VSCSEDKTIKIWD-TT 174
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
+ + + S + + +P + + SA +++V +W +R L++ + H V
Sbjct: 175 NKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCI 234
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
F P L+TAS D + + D G + +L H + +V FS G
Sbjct: 235 SFHPSGNYLITASSDGTLKILDLLEGRLIYTLQG------------HTGPVFTVSFSKGG 282
Query: 306 LYLATVADDRLLRIW 320
A+ D + +W
Sbjct: 283 ELFASGGADTQVLLW 297
Score = 70.9 bits (172), Expect = 2e-12
Identities = 57/218 (26%), Positives = 92/218 (42%), Gaps = 5/218 (2%)
Query: 111 WARHHPQVPDVSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILV 170
W R PD +V + D IKIW+ + N S + F PSG+ I
Sbjct: 146 WVRCAKFSPDGRLIVSCS--EDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCI-A 202
Query: 171 SASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYT 230
SA D+T+++WD+ + K +Q H V C S P + L +A+ + ++ + +
Sbjct: 203 SAGSDQTVKVWDVRVN-KLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGR 261
Query: 231 LIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGE-RLRSLHHTQVDPAMDDS 289
LI L+GH V + FS L + DT V++W E + L + DS
Sbjct: 262 LIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDS 321
Query: 290 DVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTP 327
H+ + P + TV + L + L++ TP
Sbjct: 322 PPHLLDIYPRTPHPHEEKVETVEINPKLEVIDLQISTP 359
Score = 56.6 bits (135), Expect = 4e-08
Identities = 42/162 (25%), Positives = 76/162 (46%), Gaps = 32/162 (19%)
Query: 231 LIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD--------PYTGER------LRS 276
L R +GH++++ S D SP+ L TAS+DT +++W+ Y G + S
Sbjct: 10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
Query: 277 LHHTQVDPAMDDSDV----------------HISSLRSVCFSPEGLYLATVADDRLLRIW 320
H + A D V H + +RSV FS +G +LAT ++D+ +++W
Sbjct: 70 PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
Query: 321 AL-ELKTPIAFAPMTNGL-CCTFFPHGGVIATGTRDGHVQFW 360
++ + + T+ + C F P G +I + + D ++ W
Sbjct: 130 SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 97.1 bits (240), Expect = 3e-20
Identities = 74/252 (29%), Positives = 120/252 (47%), Gaps = 34/252 (13%)
Query: 124 LVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDL 183
L L++ N + ++ E L L GH + V + F+P+G L S+S D+ + IW
Sbjct: 13 LALSSSANQSK-EVPENPNYALKCTLVGHTEAVSSVKFSPNGEW-LASSSADRLIIIWGA 70
Query: 184 NKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVV 243
GK + L GH + + S D S L SA+ +K++ LW +RS ++ L+GH + V
Sbjct: 71 YD-GKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVF 129
Query: 244 SCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSP 303
C+F+P S L+++ S+D V +W+ TG+ L++L H + +V F+
Sbjct: 130 CCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL------------SAHSDPVSAVHFNC 177
Query: 304 EGLYLATVADDRLLRIWALE----LKT-------PIAFAPMTNGLCCTFFPHGGVIATGT 352
G + + + D L RIW LKT P++F F P+G I T T
Sbjct: 178 SGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV--------KFSPNGKYILTAT 229
Query: 353 RDGHVQFWTAPR 364
D ++ W R
Sbjct: 230 LDNTLKLWDYSR 241
Score = 76.6 bits (187), Expect = 4e-14
Identities = 57/243 (23%), Positives = 108/243 (44%), Gaps = 54/243 (22%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
LA+ D I IW G L GH + D++++ S S LVSAS DKTL++WD+ +
Sbjct: 56 LASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS-SDSSRLVSASDDKTLKLWDV-R 113
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSV--- 242
GK ++ L GH +V+CC+ +P +++ S + +++V +W +++ ++ L H V
Sbjct: 114 SGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAV 173
Query: 243 -VSCD---------------------------------------FSPDSALLVTASYDTN 262
+C FSP+ ++TA+ D
Sbjct: 174 HFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNT 233
Query: 263 VIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWAL 322
+ +WD G L++ + + ++ ++ G ++ + ++D L+ IW L
Sbjct: 234 LKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG---------GKWIVSGSEDNLVYIWNL 284
Query: 323 ELK 325
+ K
Sbjct: 285 QTK 287
Score = 71.2 bits (173), Expect = 2e-12
Identities = 67/289 (23%), Positives = 119/289 (41%), Gaps = 61/289 (21%)
Query: 31 SVAFSPDGSWFAWSQGHCIVKLIPW-----PLEEQFIPKGFEAKSRS-SKNETKGRGSPK 84
SV FSP+G W A S ++ I W E+ E + S + ++ +
Sbjct: 46 SVKFSPNGEWLASSSADRLI--IIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103
Query: 85 EKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPDVSCLVLATGLNDGQIKIWEVQTGL 144
+KTL + G + +P S L+++ G D +KIWEV+TG
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPP----SNLIIS-GSFDETVKIWEVKTGK 158
Query: 145 LLLNLSGHQDVVRDLSFTPSGSLI------------------------------------ 168
L LS H D V + F SGSLI
Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218
Query: 169 ------LVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCS---MLCSAAGEK 219
+++A+ D TL++WD ++ G+ ++ +GH YC + + + S + +
Sbjct: 219 SPNGKYILTATLDNTLKLWDYSR-GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 277
Query: 220 SVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASY--DTNVIMW 266
V++W++++ +++KL+GH V+S P L+ +A+ D + +W
Sbjct: 278 LVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 96.7 bits (239), Expect = 3e-20
Identities = 79/278 (28%), Positives = 110/278 (39%), Gaps = 56/278 (20%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
LA+G D + +W ++ +GH+D V ++F+PSG L L S SRDKT+RIW N
Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL-LASGSRDKTVRIWVPNV 92
Query: 186 HG------------------------------KQIQV-----------LSGHLQWVYCCS 204
G K ++V LS H+ WV C
Sbjct: 93 KGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAK 152
Query: 205 ISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVI 264
SPD ++ SA+ +K+V LW S + H V DF P + A D V
Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVK 212
Query: 265 MWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALEL 324
+WD T R L H Q +H +++ + F P G YL T + D L+I L
Sbjct: 213 VWDVRTH---RLLQHYQ---------LHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 260
Query: 325 KTPIAFAPMTNGLCCT--FFPHGGVIATGTRDGHVQFW 360
+ G T F G A+G D V W
Sbjct: 261 GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 68.2 bits (165), Expect = 1e-11
Identities = 44/168 (26%), Positives = 73/168 (43%), Gaps = 14/168 (8%)
Query: 195 GHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALL 254
GH V C S + L S + + + +W M+ + + GH+ +V +FSP LL
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 255 VTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADD 314
+ S D V +W P V H +++RSV F +G T +DD
Sbjct: 77 ASGSRDKTVRIWVP------------NVKGESTVFRAHTATVRSVHFCSDGQSFVTASDD 124
Query: 315 RLLRIWAL-ELKTPIAFAPMTNGL-CCTFFPHGGVIATGTRDGHVQFW 360
+ +++WA K + + N + C F P G +I + + D V+ W
Sbjct: 125 KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 96.7 bits (239), Expect = 3e-20
Identities = 79/278 (28%), Positives = 110/278 (39%), Gaps = 56/278 (20%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
LA+G D + +W ++ +GH+D V ++F+PSG L L S SRDKT+RIW N
Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL-LASGSRDKTVRIWVPNV 92
Query: 186 HG------------------------------KQIQV-----------LSGHLQWVYCCS 204
G K ++V LS H+ WV C
Sbjct: 93 KGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAK 152
Query: 205 ISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVI 264
SPD ++ SA+ +K+V LW S + H V DF P + A D V
Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVK 212
Query: 265 MWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALEL 324
+WD T R L H Q +H +++ + F P G YL T + D L+I L
Sbjct: 213 VWDVRTH---RLLQHYQ---------LHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 260
Query: 325 KTPIAFAPMTNGLCCT--FFPHGGVIATGTRDGHVQFW 360
+ G T F G A+G D V W
Sbjct: 261 GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 68.2 bits (165), Expect = 1e-11
Identities = 44/168 (26%), Positives = 73/168 (43%), Gaps = 14/168 (8%)
Query: 195 GHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALL 254
GH V C S + L S + + + +W M+ + + GH+ +V +FSP LL
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 255 VTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADD 314
+ S D V +W P V H +++RSV F +G T +DD
Sbjct: 77 ASGSRDKTVRIWVP------------NVKGESTVFRAHTATVRSVHFCSDGQSFVTASDD 124
Query: 315 RLLRIWAL-ELKTPIAFAPMTNGL-CCTFFPHGGVIATGTRDGHVQFW 360
+ +++WA K + + N + C F P G +I + + D V+ W
Sbjct: 125 KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 94.0 bits (232), Expect = 2e-19
Identities = 54/195 (27%), Positives = 95/195 (48%), Gaps = 14/195 (7%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
L + DG +++W +QT L+ GH V D F+P G VS D+ R+W +
Sbjct: 558 LLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG-YYFVSGGHDRVARLWATD- 615
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
H + +++ +GHL V C P+ + + + + +++V LW + + +R GH+ + S
Sbjct: 616 HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL 675
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
FSP+ L T + D V++WD G + L H ++ S+ FS +G
Sbjct: 676 TFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG------------HTDTVCSLRFSRDG 723
Query: 306 LYLATVADDRLLRIW 320
LA+ + D +R+W
Sbjct: 724 EILASGSMDNTVRLW 738
Score = 81.3 bits (199), Expect = 1e-15
Identities = 69/248 (27%), Positives = 106/248 (42%), Gaps = 34/248 (13%)
Query: 118 VPDVSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKT 177
V D S L+ A G D +++W V L S + L L+ D
Sbjct: 478 VTDDSSLI-AGGFADSTVRVWSVTPKKLR-------------SVKQASDLSLIDKESDDV 523
Query: 178 L-RIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLE 236
L RI D K ++++L GH VY S SPD + L S++ + +V LWS++++T + +
Sbjct: 524 LERIMD-EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK 582
Query: 237 GHQSSVVSCDFSPDSALLVTASYDTNVIMW--DPYTGERLRSLHHTQVDPAMDDSDVHIS 294
GH V FSP V+ +D +W D Y R+ + H++
Sbjct: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFA--------------GHLA 628
Query: 295 SLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNG--LCCTFFPHGGVIATGT 352
+ F P Y+AT + DR +R+W + + G TF P+G +ATG
Sbjct: 629 DVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGA 688
Query: 353 RDGHVQFW 360
DG V W
Sbjct: 689 TDGRVLLW 696
Score = 80.5 bits (197), Expect = 3e-15
Identities = 65/237 (27%), Positives = 101/237 (42%), Gaps = 16/237 (6%)
Query: 136 KIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSG 195
+I + +T L L GH V SF+P + +L S+S D T+R+W L + G
Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLL-SSSEDGTVRLWSLQTFTCLVGY-KG 583
Query: 196 HLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLV 255
H V+ SP S ++ LW+ Y +R GH + V F P+S +
Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
Query: 256 TASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDR 315
T S D V +WD G +R H + S+ FSP G +LAT A D
Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTG------------HKGPIHSLTFSPNGRFLATGATDG 691
Query: 316 LLRIWALELKTPIA-FAPMTNGLCCTFFPHGG-VIATGTRDGHVQFWTAPRVLSSLK 370
+ +W + + T+ +C F G ++A+G+ D V+ W A + L+
Sbjct: 692 RVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLE 748
Score = 55.8 bits (133), Expect = 7e-08
Identities = 27/60 (45%), Positives = 37/60 (61%), Gaps = 1/60 (1%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
LATG DG++ +W++ GL++ L GH D V L F+ G IL S S D T+R+WD K
Sbjct: 684 LATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWDAIK 742
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 93.2 bits (230), Expect = 4e-19
Identities = 57/199 (28%), Positives = 97/199 (48%), Gaps = 15/199 (7%)
Query: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
++ G G I++W+++ +L L GH+ + L F P G + S S+D +++WD+
Sbjct: 77 LIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWDIR 135
Query: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
+ G + GH Q V C SPD L SAA + +V LW + + ++ + GH V
Sbjct: 136 RKGCVFRY-RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNV 194
Query: 245 CDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPE 304
+F P+ LL + S D + WD E+ + + + +P +RSV F+P+
Sbjct: 195 VEFHPNEYLLASGSSDRTIRFWDL---EKFQVVSCIEGEP---------GPVRSVLFNPD 242
Query: 305 GLYLATVADDRLLRIWALE 323
G L + D LR++ E
Sbjct: 243 GCCLYSGCQDS-LRVYGWE 260
Score = 85.5 bits (210), Expect = 8e-17
Identities = 54/199 (27%), Positives = 92/199 (46%), Gaps = 14/199 (7%)
Query: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
+LATG +D ++ +W + +++L+GH V + LI V+ S+ ++R+WDL
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI-VAGSQSGSIRVWDL- 92
Query: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
+ K ++ L GH + P + S + + ++ LW +R + + GH +V
Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
Query: 245 CDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPE 304
FSPD L +A+ D V +WD G+ M + H + V F P
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGK------------MMSEFPGHTGPVNVVEFHPN 200
Query: 305 GLYLATVADDRLLRIWALE 323
LA+ + DR +R W LE
Sbjct: 201 EYLLASGSSDRTIRFWDLE 219
Score = 84.7 bits (208), Expect = 1e-16
Identities = 56/223 (25%), Positives = 104/223 (46%), Gaps = 17/223 (7%)
Query: 141 QTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWV 200
+T L + H V L + +L + D + +W +NK I L+GH V
Sbjct: 8 KTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNC-IMSLTGHTSPV 66
Query: 201 YCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYD 260
++ ++ + + S+ +W + + ++R L GH++++ S DF P + + S D
Sbjct: 67 ESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQD 126
Query: 261 TNVIMWD-PYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRI 319
TN+ +WD G R H+Q ++R + FSP+G +LA+ ADD +++
Sbjct: 127 TNIKLWDIRRKGCVFRYRGHSQ-------------AVRCLRFSPDGKWLASAADDHTVKL 173
Query: 320 WALELKTPIAFAPMTNG--LCCTFFPHGGVIATGTRDGHVQFW 360
W L ++ P G F P+ ++A+G+ D ++FW
Sbjct: 174 WDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
Score = 32.7 bits (73), Expect = 0.60
Identities = 34/137 (24%), Positives = 57/137 (41%), Gaps = 17/137 (12%)
Query: 232 IRKLEGHQSSVVSCDFSPDSA-LLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSD 290
++++ H S+V S S LL T D V +W + SL
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTG----------- 61
Query: 291 VHISSLRSVCFS-PEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCT--FFPHGGV 347
H S + SV + PE L +A + +R+W LE + C+ F P+G
Sbjct: 62 -HTSPVESVRLNTPEELIVAG-SQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEF 119
Query: 348 IATGTRDGHVQFWTAPR 364
+A+G++D +++ W R
Sbjct: 120 VASGSQDTNIKLWDIRR 136
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 93.2 bits (230), Expect = 4e-19
Identities = 70/238 (29%), Positives = 100/238 (42%), Gaps = 16/238 (6%)
Query: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
+LA+G D ++IW H VR + F G V+AS DKT+++W +
Sbjct: 37 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF-VTASDDKTVKVWATH 95
Query: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
+ K + LS H+ WV C SPD ++ SA+ +K+V LW S + H V
Sbjct: 96 RQ-KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY 154
Query: 245 CDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPE 304
DF P + A D V +WD T R L H Q +H +++ + F P
Sbjct: 155 VDFHPSGTCIAAAGMDNTVKVWDVRTH---RLLQHYQ---------LHSAAVNGLSFHPS 202
Query: 305 GLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCT--FFPHGGVIATGTRDGHVQFW 360
G YL T + D L+I L + G T F G A+G D V W
Sbjct: 203 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 58.2 bits (139), Expect = 1e-08
Identities = 37/145 (25%), Positives = 64/145 (44%), Gaps = 14/145 (9%)
Query: 218 EKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSL 277
+ + +W M+ + + GH+ +V +FSP LL + S D V +W P
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVP--------- 52
Query: 278 HHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWAL-ELKTPIAFAPMTNG 336
V H +++RSV F +G T +DD+ +++WA K + + N
Sbjct: 53 ---NVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINW 109
Query: 337 L-CCTFFPHGGVIATGTRDGHVQFW 360
+ C F P G +I + + D V+ W
Sbjct: 110 VRCAKFSPDGRLIVSASDDKTVKLW 134
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 90.5 bits (223), Expect = 2e-18
Identities = 78/327 (23%), Positives = 131/327 (40%), Gaps = 84/327 (25%)
Query: 103 PSPPSRKLWARHHPQVPDVSC----LVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRD 158
P PP + + H V V V+ + D IK+W+ +TG L GH D V+D
Sbjct: 96 PRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQD 155
Query: 159 LSFTPSGSLI-----------------------------------------LVSASRDKT 177
+SF SG L+ +VSASRDKT
Sbjct: 156 ISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKT 215
Query: 178 LRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEG 237
+++W++ G ++ +GH +WV + D +++ S + +++V +W + + +L
Sbjct: 216 IKMWEVQT-GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE 274
Query: 238 HQSSVVSCDFSPDSA--------------------LLVTASYDTNVIMWDPYTGERLRSL 277
H+ V ++P+S+ L++ S D + MWD TG L +L
Sbjct: 275 HEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL 334
Query: 278 HHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALE----LKTPIAFAPM 333
H + +R V F G ++ + ADD+ LR+W + +KT A
Sbjct: 335 VG------------HDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHF 382
Query: 334 TNGLCCTFFPHGGVIATGTRDGHVQFW 360
L F + TG+ D V+ W
Sbjct: 383 VTSL--DFHKTAPYVVTGSVDQTVKVW 407
Score = 73.6 bits (179), Expect = 3e-13
Identities = 45/168 (26%), Positives = 76/168 (45%), Gaps = 20/168 (11%)
Query: 119 PDVSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSL----------- 167
P+ ++A+ ND +++W V T L H+ VV +S+ P S
Sbjct: 242 PNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSET 301
Query: 168 --------ILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEK 219
L+S SRDKT+++WD++ G + L GH WV + S A +K
Sbjct: 302 KKSGKPGPFLLSGSRDKTIKMWDVST-GMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 360
Query: 220 SVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD 267
++ +W ++ ++ L H+ V S DF + +VT S D V +W+
Sbjct: 361 TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 89.4 bits (220), Expect = 5e-18
Identities = 53/189 (28%), Positives = 92/189 (48%), Gaps = 14/189 (7%)
Query: 132 DGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQ 191
D I+ W++ + + GH V DL +P SL S S D+T R+W ++ ++
Sbjct: 363 DMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY-SLYFASGSHDRTARLWSFDRT-YPLR 420
Query: 192 VLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDS 251
+ +GHL V C P+ + L + + +K+V LWS + +R GH+ V+S FSP+
Sbjct: 421 IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG 480
Query: 252 ALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATV 311
L +A D + +WD +G + L H ++ S+ FSP+ +A+
Sbjct: 481 KYLASAGEDQRLKLWDLASGTLYKELRG------------HTDNITSLTFSPDSGLIASA 528
Query: 312 ADDRLLRIW 320
+ D +R+W
Sbjct: 529 SMDNSVRVW 537
Score = 87.4 bits (215), Expect = 2e-17
Identities = 48/144 (33%), Positives = 78/144 (54%), Gaps = 2/144 (1%)
Query: 124 LVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDL 183
L A+G +D ++W L +GH V + F P+ + L + S DKT+R+W
Sbjct: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNY-LATGSTDKTVRLWSA 455
Query: 184 NKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVV 243
+ G +++ +GH V + SP+ L SA ++ + LW + S TL ++L GH ++
Sbjct: 456 QQ-GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
Query: 244 SCDFSPDSALLVTASYDTNVIMWD 267
S FSPDS L+ +AS D +V +WD
Sbjct: 515 SLTFSPDSGLIASASMDNSVRVWD 538
Score = 84.3 bits (207), Expect = 2e-16
Identities = 73/260 (28%), Positives = 107/260 (41%), Gaps = 23/260 (8%)
Query: 109 KLWA------RHHPQVPDVSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFT 162
KLW+ + P DVS + LA + + + + G + L GH V F
Sbjct: 293 KLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDE-DDNAGTEMKILRGHCGPVYSTRFL 351
Query: 163 PSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVF 222
S +L S S D ++R WDL + + GH V+ ISP S + +++
Sbjct: 352 ADSSGLL-SCSEDMSIRYWDLGSFTNTV-LYQGHAYPVWDLDISPYSLYFASGSHDRTAR 409
Query: 223 LWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQV 282
LWS +R GH + V F P+S L T S D V +W G +R
Sbjct: 410 LWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTG--- 466
Query: 283 DPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKT--PIAFAPMTNGLCCT 340
H + S+ FSP G YLA+ +D+ L++W L T N T
Sbjct: 467 ---------HRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLT 517
Query: 341 FFPHGGVIATGTRDGHVQFW 360
F P G+IA+ + D V+ W
Sbjct: 518 FSPDSGLIASASMDNSVRVW 537
Score = 77.4 bits (189), Expect = 2e-14
Identities = 60/202 (29%), Positives = 92/202 (45%), Gaps = 35/202 (17%)
Query: 94 VWGLAFSPWP-------SPPSRKLWA--RHHP------QVPDVSCL-------VLATGLN 131
VW L SP+ + +LW+ R +P + DV C+ LATG
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 446
Query: 132 DGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQ 191
D +++W Q G + +GH+ V L+F+P+G L SA D+ L++WDL G +
Sbjct: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKY-LASAGEDQRLKLWDLAS-GTLYK 504
Query: 192 VLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMR-----------SYTLIRKLEGHQS 240
L GH + + SPD ++ SA+ + SV +W +R S L+ G S
Sbjct: 505 ELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMS 564
Query: 241 SVVSCDFSPDSALLVTASYDTN 262
+V+S F + LLVT N
Sbjct: 565 NVLSVQFMACNLLLVTGITQEN 586
Score = 57.0 bits (136), Expect = 3e-08
Identities = 49/199 (24%), Positives = 78/199 (39%), Gaps = 46/199 (23%)
Query: 198 QWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTL-------------------------- 231
Q + ISPD +L + + LWS+RS L
Sbjct: 269 QLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDED 328
Query: 232 ------IRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPA 285
++ L GH V S F DS+ L++ S D ++ WD L S +T +
Sbjct: 329 DNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWD------LGSFTNTVLYQG 382
Query: 286 MDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAF--APMTNGLCCTFFP 343
H + + SP LY A+ + DR R+W+ + P+ + + C F P
Sbjct: 383 ------HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHP 436
Query: 344 HGGVIATGTRDGHVQFWTA 362
+ +ATG+ D V+ W+A
Sbjct: 437 NSNYLATGSTDKTVRLWSA 455
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 88.6 bits (218), Expect = 9e-18
Identities = 62/234 (26%), Positives = 108/234 (46%), Gaps = 16/234 (6%)
Query: 128 TGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHG 187
TG D IKIW++ +G L L+L+GH VR + + S L S DK ++ WDL ++
Sbjct: 221 TGSADRTIKIWDLASGKLKLSLTGHISTVRGV-IVSTRSPYLFSCGEDKQVKCWDL-EYN 278
Query: 188 KQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDF 247
K I+ GHL VY + P +L + + + + +W +R+ + L GH ++V +
Sbjct: 279 KVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRC 338
Query: 248 SPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLY 307
++T S+DT + +WD G+ +L + H S+R+V P
Sbjct: 339 QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTN------------HKKSVRAVVLHPRHYT 386
Query: 308 LATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHG-GVIATGTRDGHVQFW 360
A+ + D ++ W + I N + T + GV+ +G +G + W
Sbjct: 387 FASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLW 439
Score = 66.2 bits (160), Expect = 5e-11
Identities = 68/312 (21%), Positives = 124/312 (39%), Gaps = 26/312 (8%)
Query: 32 VAFSPDGSWFAWSQGHCIVKLIPWPLEEQFIPKGFEAKSRSSKNETKGRGSP------KE 85
+A P WF +K+ W L + + + SP ++
Sbjct: 210 IAVEPGNQWFVTGSADRTIKI--WDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGED 267
Query: 86 KTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPDVSCLVLATGLNDGQIKIWEVQTGLL 145
K + C + + + S HP + VL T D +IW+V+T
Sbjct: 268 KQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTID-----VLVTCSRDSTARIWDVRTKAS 322
Query: 146 LLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSI 205
+ LSGH + V + + I ++ S D T+R+WDL GK L+ H + V +
Sbjct: 323 VHTLSGHTNAVATVRCQAAEPQI-ITGSHDTTIRLWDL-VAGKTRVTLTNHKKSVRAVVL 380
Query: 206 SPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIM 265
P S + + ++ W + I+ L GH + + + + D +LV+ + + + +
Sbjct: 381 HPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSD-GVLVSGADNGTMHL 438
Query: 266 WDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIW----- 320
WD TG + + H V P DS+ S + + F L T D+ ++++
Sbjct: 439 WDWRTGYNFQRV-HAAVQPGSLDSE---SGIFACAFDQSESRLLTAEADKTIKVYREDDT 494
Query: 321 ALELKTPIAFAP 332
A E P+++ P
Sbjct: 495 ATEETHPVSWKP 506
Score = 61.2 bits (147), Expect = 2e-09
Identities = 46/178 (25%), Positives = 74/178 (41%), Gaps = 20/178 (11%)
Query: 188 KQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDF 247
K +V+SGHL WV C ++ P + + ++++ +W + S L L GH S+V
Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
Query: 248 SPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLY 307
S S L + D V WD + +R H H+S++ + P
Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHG------------HLSAVYGLDLHPTIDV 302
Query: 308 LATVADDRLLRIWALELKTPI-AFAPMTNGL----CCTFFPHGGVIATGTRDGHVQFW 360
L T + D RIW + K + + TN + C P I TG+ D ++ W
Sbjct: 303 LVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQ---IITGSHDTTIRLW 357
Score = 41.6 bits (96), Expect = 0.001
Identities = 34/134 (25%), Positives = 53/134 (39%), Gaps = 14/134 (10%)
Query: 229 YTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDD 288
+ L R + GH V P + VT S D + +WD +G+ SL
Sbjct: 194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSL----------- 242
Query: 289 SDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIA--FAPMTNGLCCTFFPHGG 346
HIS++R V S YL + +D+ ++ W LE I ++ P
Sbjct: 243 -TGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTID 301
Query: 347 VIATGTRDGHVQFW 360
V+ T +RD + W
Sbjct: 302 VLVTCSRDSTARIW 315
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 86.7 bits (213), Expect = 4e-17
Identities = 65/210 (30%), Positives = 98/210 (46%), Gaps = 27/210 (12%)
Query: 124 LVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDL 183
L+LATG +D +K+W++ + GH + V F+P L L S S D TL++WD
Sbjct: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKL-LASCSADGTLKLWDA 772
Query: 184 N--KHGKQIQVLSGHLQW----------VYCCSISPDCSMLCSAAGEKSVFLWSMRSYTL 231
K I V L V CCS S D + + AA K +FL+ + + L
Sbjct: 773 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGL 831
Query: 232 IRKLE-GHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSD 290
+ ++ GH S++ CDFSP + L V A V +W +T + D
Sbjct: 832 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW------------NTDSRSKVADCR 879
Query: 291 VHISSLRSVCFSPEGLYLATVADDRLLRIW 320
H+S + V FSP+G T +DD+ +R+W
Sbjct: 880 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLW 909
Score = 77.0 bits (188), Expect = 3e-14
Identities = 51/183 (27%), Positives = 85/183 (46%), Gaps = 8/183 (4%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
L + +D +I++W Q + L GHQ+ V+D + L+ S S D T+++W++
Sbjct: 1018 LISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL--SWSFDGTVKVWNIIT 1074
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
K+ + H V C IS D + S + +K+ +WS + +L GH V
Sbjct: 1075 GNKEKDFVC-HQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCS 1133
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
FS DS LL T + + +W+ GE L H + + + H + +CFSP+G
Sbjct: 1134 AFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSEEGAATHGGWVTDLCFSPDG 1189
Query: 306 LYL 308
L
Sbjct: 1190 KML 1192
Score = 75.9 bits (185), Expect = 6e-14
Identities = 48/188 (25%), Positives = 87/188 (46%), Gaps = 5/188 (2%)
Query: 132 DGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQ 191
D +++++ +TG LL + H+D V +F+ I + S DK ++IW+ + G+ +
Sbjct: 636 DKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI-ATCSVDKKVKIWN-SMTGELVH 693
Query: 192 VLSGHLQWVYCCSISPDCSMLCSAAGEKSVFL--WSMRSYTLIRKLEGHQSSVVSCDFSP 249
H + V CC + L A G FL W + + GH +SV C FSP
Sbjct: 694 TYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSP 753
Query: 250 DSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVC-FSPEGLYL 308
D LL + S D + +WD + +S++ Q ++D + + C +S +G +
Sbjct: 754 DDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI 813
Query: 309 ATVADDRL 316
A +++
Sbjct: 814 MVAAKNKI 821
Score = 64.3 bits (155), Expect = 2e-10
Identities = 56/249 (22%), Positives = 106/249 (42%), Gaps = 34/249 (13%)
Query: 125 VLATGLNDGQIKIWE---------VQTGLLLLNLSGHQD----VVRDLSFTPSGSLILVS 171
+LA+ DG +K+W+ + LNL Q+ +V+ S++ G+ I+V+
Sbjct: 757 LLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVA 816
Query: 172 ASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTL 231
A + ++D++ G ++ +GH + C SP + A + V LW+ S +
Sbjct: 817 AKNK--IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSK 874
Query: 232 IRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD-PYTGERLRSLHHTQVDPAMDDSD 290
+ GH S V FSPD + +T+S D + +W+ + + +VD +++
Sbjct: 875 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENE 934
Query: 291 VHISSLRSVCFSPEGLYLATVADDRLLRIWALELKT-PIAFAPMTNGLCCTFFPHGGVIA 349
V + +A D + R+ + +T I + CC PH IA
Sbjct: 935 VMV-----------------LAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 977
Query: 350 TGTRDGHVQ 358
G +G ++
Sbjct: 978 FGDENGAIE 986
Score = 63.9 bits (154), Expect = 2e-10
Identities = 45/173 (26%), Positives = 77/173 (44%), Gaps = 12/173 (6%)
Query: 192 VLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDS 251
V+ H VY S D + S +K++ ++ + + +++ H+ V+ C FS D
Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
Query: 252 ALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATV 311
+ T S D V +W+ TGE L HT + + + H ++ S L LAT
Sbjct: 670 RFIATCSVDKKVKIWNSMTGE----LVHTYDEHSEQVNCCHFTN------SSHHLLLATG 719
Query: 312 ADDRLLRIWALELK--TPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTA 362
+ D L++W L K F + C F P ++A+ + DG ++ W A
Sbjct: 720 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 772
Score = 60.1 bits (144), Expect = 4e-09
Identities = 58/305 (19%), Positives = 115/305 (37%), Gaps = 69/305 (22%)
Query: 135 IKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK--------- 185
+++W + + + GH V + F+P GS L S S D+T+R+W+ K
Sbjct: 864 VELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS-SDDQTIRLWETKKVCKNSAVML 922
Query: 186 -------------------HGKQIQVLSGHL--------QWVYCCSISPDCSMLCSAAGE 218
H +++Q+++G V CC +SP +
Sbjct: 923 KQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDEN 982
Query: 219 KSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD----------- 267
++ + + + + + H+ +V F+ D L+++S D + +W+
Sbjct: 983 GAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRG 1042
Query: 268 -PYTGERLRSLHHTQVDPAMDDSDV----------------HISSLRSVCFSPEGLYLAT 310
T + R L ++++ D V H ++ S S + ++
Sbjct: 1043 HQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSS 1102
Query: 311 VADDRLLRIWALELKTPIAFAPMTNGL--CCTFFPHGGVIATGTRDGHVQFWTAPRVLSS 368
+ D+ +IW+ +L P+ NG C F ++ATG +G ++ W
Sbjct: 1103 TSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN--GE 1160
Query: 369 LKHLC 373
L HLC
Sbjct: 1161 LLHLC 1165
Score = 53.9 bits (128), Expect = 3e-07
Identities = 62/247 (25%), Positives = 110/247 (44%), Gaps = 32/247 (12%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
+A G +G I+I E+ + + H+ V + FT + L+S+S D +++W N
Sbjct: 976 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFT-ADEKTLISSSDDAEIQVW--NW 1032
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
+ L GH + V + + S L S + + +V +W++ + + HQ +V+SC
Sbjct: 1033 QLDKCIFLRGHQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1091
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
D S D+ + S D +W + + L LH + H +R FS +
Sbjct: 1092 DISHDATKFSSTSADKTAKIW---SFDLLLPLHELRG---------HNGCVRCSAFSVDS 1139
Query: 306 LYLATVADDRLLRIW------ALELKTPIA-FAPMTNG-----LCCTFFPHGGVIATGTR 353
LAT D+ +RIW L L P++ T+G LC F P G ++ +
Sbjct: 1140 TLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC--FSPDGKMLISA-- 1195
Query: 354 DGHVQFW 360
G++++W
Sbjct: 1196 GGYIKWW 1202
Score = 36.2 bits (82), Expect = 0.054
Identities = 22/57 (38%), Positives = 32/57 (56%), Gaps = 8/57 (14%)
Query: 121 VSCLVLATGLNDGQIKIWEVQTGLLL-----LNLSG---HQDVVRDLSFTPSGSLIL 169
V +LATG ++G+I+IW V G LL L+ G H V DL F+P G +++
Sbjct: 1137 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1193
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 86.7 bits (213), Expect = 4e-17
Identities = 65/210 (30%), Positives = 98/210 (46%), Gaps = 27/210 (12%)
Query: 124 LVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDL 183
L+LATG +D +K+W++ + GH + V F+P L L S S D TL++WD
Sbjct: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKL-LASCSADGTLKLWDA 761
Query: 184 N--KHGKQIQVLSGHLQW----------VYCCSISPDCSMLCSAAGEKSVFLWSMRSYTL 231
K I V L V CCS S D + + AA K +FL+ + + L
Sbjct: 762 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGL 820
Query: 232 IRKLE-GHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSD 290
+ ++ GH S++ CDFSP + L V A V +W +T + D
Sbjct: 821 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW------------NTDSRSKVADCR 868
Query: 291 VHISSLRSVCFSPEGLYLATVADDRLLRIW 320
H+S + V FSP+G T +DD+ +R+W
Sbjct: 869 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLW 898
Score = 77.0 bits (188), Expect = 3e-14
Identities = 51/183 (27%), Positives = 85/183 (46%), Gaps = 8/183 (4%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
L + +D +I++W Q + L GHQ+ V+D + L+ S S D T+++W++
Sbjct: 1007 LISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL--SWSFDGTVKVWNIIT 1063
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
K+ + H V C IS D + S + +K+ +WS + +L GH V
Sbjct: 1064 GNKEKDFVC-HQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCS 1122
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
FS DS LL T + + +W+ GE L H + + + H + +CFSP+G
Sbjct: 1123 AFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSEEGAATHGGWVTDLCFSPDG 1178
Query: 306 LYL 308
L
Sbjct: 1179 KML 1181
Score = 75.9 bits (185), Expect = 6e-14
Identities = 48/188 (25%), Positives = 87/188 (46%), Gaps = 5/188 (2%)
Query: 132 DGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQ 191
D +++++ +TG LL + H+D V +F+ I + S DK ++IW+ + G+ +
Sbjct: 625 DKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI-ATCSVDKKVKIWN-SMTGELVH 682
Query: 192 VLSGHLQWVYCCSISPDCSMLCSAAGEKSVFL--WSMRSYTLIRKLEGHQSSVVSCDFSP 249
H + V CC + L A G FL W + + GH +SV C FSP
Sbjct: 683 TYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSP 742
Query: 250 DSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVC-FSPEGLYL 308
D LL + S D + +WD + +S++ Q ++D + + C +S +G +
Sbjct: 743 DDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI 802
Query: 309 ATVADDRL 316
A +++
Sbjct: 803 MVAAKNKI 810
Score = 64.3 bits (155), Expect = 2e-10
Identities = 56/249 (22%), Positives = 106/249 (42%), Gaps = 34/249 (13%)
Query: 125 VLATGLNDGQIKIWE---------VQTGLLLLNLSGHQD----VVRDLSFTPSGSLILVS 171
+LA+ DG +K+W+ + LNL Q+ +V+ S++ G+ I+V+
Sbjct: 746 LLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVA 805
Query: 172 ASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTL 231
A + ++D++ G ++ +GH + C SP + A + V LW+ S +
Sbjct: 806 AKNK--IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSK 863
Query: 232 IRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD-PYTGERLRSLHHTQVDPAMDDSD 290
+ GH S V FSPD + +T+S D + +W+ + + +VD +++
Sbjct: 864 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENE 923
Query: 291 VHISSLRSVCFSPEGLYLATVADDRLLRIWALELKT-PIAFAPMTNGLCCTFFPHGGVIA 349
V + +A D + R+ + +T I + CC PH IA
Sbjct: 924 VMV-----------------LAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 966
Query: 350 TGTRDGHVQ 358
G +G ++
Sbjct: 967 FGDENGAIE 975
Score = 63.9 bits (154), Expect = 2e-10
Identities = 45/173 (26%), Positives = 77/173 (44%), Gaps = 12/173 (6%)
Query: 192 VLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDS 251
V+ H VY S D + S +K++ ++ + + +++ H+ V+ C FS D
Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
Query: 252 ALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATV 311
+ T S D V +W+ TGE L HT + + + H ++ S L LAT
Sbjct: 659 RFIATCSVDKKVKIWNSMTGE----LVHTYDEHSEQVNCCHFTN------SSHHLLLATG 708
Query: 312 ADDRLLRIWALELK--TPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTA 362
+ D L++W L K F + C F P ++A+ + DG ++ W A
Sbjct: 709 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 761
Score = 60.1 bits (144), Expect = 4e-09
Identities = 58/305 (19%), Positives = 115/305 (37%), Gaps = 69/305 (22%)
Query: 135 IKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK--------- 185
+++W + + + GH V + F+P GS L S S D+T+R+W+ K
Sbjct: 853 VELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS-SDDQTIRLWETKKVCKNSAVML 911
Query: 186 -------------------HGKQIQVLSGHL--------QWVYCCSISPDCSMLCSAAGE 218
H +++Q+++G V CC +SP +
Sbjct: 912 KQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDEN 971
Query: 219 KSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD----------- 267
++ + + + + + H+ +V F+ D L+++S D + +W+
Sbjct: 972 GAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRG 1031
Query: 268 -PYTGERLRSLHHTQVDPAMDDSDV----------------HISSLRSVCFSPEGLYLAT 310
T + R L ++++ D V H ++ S S + ++
Sbjct: 1032 HQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSS 1091
Query: 311 VADDRLLRIWALELKTPIAFAPMTNGL--CCTFFPHGGVIATGTRDGHVQFWTAPRVLSS 368
+ D+ +IW+ +L P+ NG C F ++ATG +G ++ W
Sbjct: 1092 TSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN--GE 1149
Query: 369 LKHLC 373
L HLC
Sbjct: 1150 LLHLC 1154
Score = 53.9 bits (128), Expect = 3e-07
Identities = 62/247 (25%), Positives = 110/247 (44%), Gaps = 32/247 (12%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
+A G +G I+I E+ + + H+ V + FT + L+S+S D +++W N
Sbjct: 965 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFT-ADEKTLISSSDDAEIQVW--NW 1021
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
+ L GH + V + + S L S + + +V +W++ + + HQ +V+SC
Sbjct: 1022 QLDKCIFLRGHQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1080
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
D S D+ + S D +W + + L LH + H +R FS +
Sbjct: 1081 DISHDATKFSSTSADKTAKIW---SFDLLLPLHELRG---------HNGCVRCSAFSVDS 1128
Query: 306 LYLATVADDRLLRIW------ALELKTPIA-FAPMTNG-----LCCTFFPHGGVIATGTR 353
LAT D+ +RIW L L P++ T+G LC F P G ++ +
Sbjct: 1129 TLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC--FSPDGKMLISA-- 1184
Query: 354 DGHVQFW 360
G++++W
Sbjct: 1185 GGYIKWW 1191
Score = 36.2 bits (82), Expect = 0.054
Identities = 22/57 (38%), Positives = 32/57 (56%), Gaps = 8/57 (14%)
Query: 121 VSCLVLATGLNDGQIKIWEVQTGLLL-----LNLSG---HQDVVRDLSFTPSGSLIL 169
V +LATG ++G+I+IW V G LL L+ G H V DL F+P G +++
Sbjct: 1126 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1182
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 84.7 bits (208), Expect = 1e-16
Identities = 57/200 (28%), Positives = 96/200 (48%), Gaps = 17/200 (8%)
Query: 128 TGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHG 187
+G DG +++W++ TG GH V ++F+ S + +VS SRDKT+++W+
Sbjct: 80 SGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS-SDNRQIVSGSRDKTIKLWNTLGVC 138
Query: 188 KQIQVLSGHLQWVYCCSISPDCS--MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
K H +WV C SP+ S ++ S +K V +W++ + L GH + +
Sbjct: 139 KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTV 198
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
SPD +L + D ++WD G+ L +L D D+ + ++CFSP
Sbjct: 199 TVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL---------DGGDI----INALCFSPNR 245
Query: 306 LYLATVADDRLLRIWALELK 325
+L A ++IW LE K
Sbjct: 246 YWLC-AATGPSIKIWDLEGK 264
Score = 81.6 bits (200), Expect = 1e-15
Identities = 68/234 (29%), Positives = 108/234 (46%), Gaps = 27/234 (11%)
Query: 149 LSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK----HGKQIQVLSGHLQWVYCCS 204
L GH V ++ TP +++SASRDKT+ +W L + +G + L GH +V
Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70
Query: 205 ISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVI 264
IS D S + + ++ LW + + T R+ GH V+S FS D+ +V+ S D +
Sbjct: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130
Query: 265 MWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGL--YLATVADDRLLRIWAL 322
+W+ L +T D + H + V FSP + + D+L+++W L
Sbjct: 131 LWN-----TLGVCKYTVQD------ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179
Query: 323 ---ELKT-PIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTAPRVLSSLKHL 372
+LKT I N + T P G + A+G +DG W L+ KHL
Sbjct: 180 ANCKLKTNHIGHTGYLNTV--TVSPDGSLCASGGKDGQAMLWD----LNEGKHL 227
Score = 35.8 bits (81), Expect = 0.071
Identities = 31/105 (29%), Positives = 52/105 (49%), Gaps = 8/105 (7%)
Query: 119 PDVSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTL 178
PD S + A+G DGQ +W++ G L L G D++ L F+P + + A+ ++
Sbjct: 202 PDGS--LCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP--NRYWLCAATGPSI 256
Query: 179 RIWDLNKHGKQI-QVLSGHLQWVYCCSISPDCSMLCSAAGEKSVF 222
+IWDL GK I L + + P C+ L +A +++F
Sbjct: 257 KIWDL--EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 84.7 bits (208), Expect = 1e-16
Identities = 60/267 (22%), Positives = 118/267 (44%), Gaps = 12/267 (4%)
Query: 132 DGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQ 191
D +++++ +TG LL + H+D V +F+ I + S DK ++IW+ + G+ +
Sbjct: 636 DKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI-ATCSVDKKVKIWN-SMTGELVH 693
Query: 192 VLSGHLQWVYCCSISPDCSMLCSAAGEKSVFL--WSMRSYTLIRKLEGHQSSVVSCDFSP 249
H + V CC + L A G FL W + + GH +SV C FSP
Sbjct: 694 TYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSP 753
Query: 250 DSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVC-FSPEGLYL 308
D LL + S D + +WD + +S++ Q ++D + + C +S +G +
Sbjct: 754 DDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI 813
Query: 309 ATVADDRLLRIWALELKTPIA----FAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTAPR 364
A +++ +W + ++ +A +G+ F P G T + D ++ W +
Sbjct: 814 MVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGV--MFSPDGSSFLTSSDDQTIRLWETKK 870
Query: 365 VLSSLKHLCRKALRSFLTTYQVLALPI 391
V + + ++ + +V+ L +
Sbjct: 871 VCKNSAVMLKQEVDVVFQENEVMVLAV 897
Score = 77.0 bits (188), Expect = 3e-14
Identities = 67/249 (26%), Positives = 106/249 (42%), Gaps = 33/249 (13%)
Query: 124 LVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDL 183
L+LATG +D +K+W++ + GH + V F+P L L S S D TL++WD
Sbjct: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKL-LASCSADGTLKLWDA 772
Query: 184 N--KHGKQIQVLSGHLQW----------VYCCSISPDCSMLCSAAGEKSVFLWSMRSYTL 231
K I V L V CCS S D + + AA K +FLW+ S +
Sbjct: 773 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSK 831
Query: 232 IRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD-PYTGERLRSLHHTQVDPAMDDSD 290
+ GH S V FSPD + +T+S D + +W+ + + +VD +++
Sbjct: 832 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENE 891
Query: 291 VHISSLRSVCFSPEGLYLATVADDRLLRIWALELKT-PIAFAPMTNGLCCTFFPHGGVIA 349
V + +A D + R+ + +T I + CC PH IA
Sbjct: 892 VMV-----------------LAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 934
Query: 350 TGTRDGHVQ 358
G +G ++
Sbjct: 935 FGDENGAIE 943
Score = 77.0 bits (188), Expect = 3e-14
Identities = 51/183 (27%), Positives = 85/183 (46%), Gaps = 8/183 (4%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
L + +D +I++W Q + L GHQ+ V+D + L+ S S D T+++W++
Sbjct: 975 LISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL--SWSFDGTVKVWNIIT 1031
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
K+ + H V C IS D + S + +K+ +WS + +L GH V
Sbjct: 1032 GNKEKDFVC-HQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCS 1090
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
FS DS LL T + + +W+ GE L H + + + H + +CFSP+G
Sbjct: 1091 AFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSEEGAATHGGWVTDLCFSPDG 1146
Query: 306 LYL 308
L
Sbjct: 1147 KML 1149
Score = 76.6 bits (187), Expect = 4e-14
Identities = 57/209 (27%), Positives = 92/209 (44%), Gaps = 28/209 (13%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSG-SLILVSASRDKTLRIWDLN 184
+AT D ++KIW TG L+ H + V FT S L+L + S D L++WDLN
Sbjct: 672 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731
Query: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKL--------- 235
+ + + GH V C SPD +L S + + ++ LW S + +
Sbjct: 732 QKECR-NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 790
Query: 236 ----EGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDV 291
E + V C +S D A ++ A+ + +W +T + D
Sbjct: 791 EDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLW------------NTDSRSKVADCRG 837
Query: 292 HISSLRSVCFSPEGLYLATVADDRLLRIW 320
H+S + V FSP+G T +DD+ +R+W
Sbjct: 838 HLSWVHGVMFSPDGSSFLTSSDDQTIRLW 866
Score = 63.9 bits (154), Expect = 2e-10
Identities = 45/173 (26%), Positives = 77/173 (44%), Gaps = 12/173 (6%)
Query: 192 VLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDS 251
V+ H VY S D + S +K++ ++ + + +++ H+ V+ C FS D
Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
Query: 252 ALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATV 311
+ T S D V +W+ TGE L HT + + + H ++ S L LAT
Sbjct: 670 RFIATCSVDKKVKIWNSMTGE----LVHTYDEHSEQVNCCHFTN------SSHHLLLATG 719
Query: 312 ADDRLLRIWALELK--TPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTA 362
+ D L++W L K F + C F P ++A+ + DG ++ W A
Sbjct: 720 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 772
Score = 59.3 bits (142), Expect = 6e-09
Identities = 59/306 (19%), Positives = 115/306 (37%), Gaps = 69/306 (22%)
Query: 134 QIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK-------- 185
+I +W + + + GH V + F+P GS L S S D+T+R+W+ K
Sbjct: 820 KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS-SDDQTIRLWETKKVCKNSAVM 878
Query: 186 --------------------HGKQIQVLSGHL--------QWVYCCSISPDCSMLCSAAG 217
H +++Q+++G V CC +SP +
Sbjct: 879 LKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDE 938
Query: 218 EKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD---------- 267
++ + + + + + H+ +V F+ D L+++S D + +W+
Sbjct: 939 NGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR 998
Query: 268 --PYTGERLRSLHHTQVDPAMDDSDV----------------HISSLRSVCFSPEGLYLA 309
T + R L ++++ D V H ++ S S + +
Sbjct: 999 GHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFS 1058
Query: 310 TVADDRLLRIWALELKTPIAFAPMTNGL--CCTFFPHGGVIATGTRDGHVQFWTAPRVLS 367
+ + D+ +IW+ +L P+ NG C F ++ATG +G ++ W
Sbjct: 1059 STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN--G 1116
Query: 368 SLKHLC 373
L HLC
Sbjct: 1117 ELLHLC 1122
Score = 53.9 bits (128), Expect = 3e-07
Identities = 62/247 (25%), Positives = 110/247 (44%), Gaps = 32/247 (12%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
+A G +G I+I E+ + + H+ V + FT + L+S+S D +++W N
Sbjct: 933 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFT-ADEKTLISSSDDAEIQVW--NW 989
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
+ L GH + V + + S L S + + +V +W++ + + HQ +V+SC
Sbjct: 990 QLDKCIFLRGHQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1048
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
D S D+ + S D +W + + L LH + H +R FS +
Sbjct: 1049 DISHDATKFSSTSADKTAKIW---SFDLLLPLHELRG---------HNGCVRCSAFSVDS 1096
Query: 306 LYLATVADDRLLRIW------ALELKTPIA-FAPMTNG-----LCCTFFPHGGVIATGTR 353
LAT D+ +RIW L L P++ T+G LC F P G ++ +
Sbjct: 1097 TLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC--FSPDGKMLISA-- 1152
Query: 354 DGHVQFW 360
G++++W
Sbjct: 1153 GGYIKWW 1159
Score = 36.2 bits (82), Expect = 0.054
Identities = 22/57 (38%), Positives = 32/57 (56%), Gaps = 8/57 (14%)
Query: 121 VSCLVLATGLNDGQIKIWEVQTGLLL-----LNLSG---HQDVVRDLSFTPSGSLIL 169
V +LATG ++G+I+IW V G LL L+ G H V DL F+P G +++
Sbjct: 1094 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1150
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 84.7 bits (208), Expect = 1e-16
Identities = 60/267 (22%), Positives = 118/267 (44%), Gaps = 12/267 (4%)
Query: 132 DGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQ 191
D +++++ +TG LL + H+D V +F+ I + S DK ++IW+ + G+ +
Sbjct: 625 DKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI-ATCSVDKKVKIWN-SMTGELVH 682
Query: 192 VLSGHLQWVYCCSISPDCSMLCSAAGEKSVFL--WSMRSYTLIRKLEGHQSSVVSCDFSP 249
H + V CC + L A G FL W + + GH +SV C FSP
Sbjct: 683 TYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSP 742
Query: 250 DSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVC-FSPEGLYL 308
D LL + S D + +WD + +S++ Q ++D + + C +S +G +
Sbjct: 743 DDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI 802
Query: 309 ATVADDRLLRIWALELKTPIA----FAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTAPR 364
A +++ +W + ++ +A +G+ F P G T + D ++ W +
Sbjct: 803 MVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGV--MFSPDGSSFLTSSDDQTIRLWETKK 859
Query: 365 VLSSLKHLCRKALRSFLTTYQVLALPI 391
V + + ++ + +V+ L +
Sbjct: 860 VCKNSAVMLKQEVDVVFQENEVMVLAV 886
Score = 77.0 bits (188), Expect = 3e-14
Identities = 67/249 (26%), Positives = 106/249 (42%), Gaps = 33/249 (13%)
Query: 124 LVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDL 183
L+LATG +D +K+W++ + GH + V F+P L L S S D TL++WD
Sbjct: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKL-LASCSADGTLKLWDA 761
Query: 184 N--KHGKQIQVLSGHLQW----------VYCCSISPDCSMLCSAAGEKSVFLWSMRSYTL 231
K I V L V CCS S D + + AA K +FLW+ S +
Sbjct: 762 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSK 820
Query: 232 IRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD-PYTGERLRSLHHTQVDPAMDDSD 290
+ GH S V FSPD + +T+S D + +W+ + + +VD +++
Sbjct: 821 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENE 880
Query: 291 VHISSLRSVCFSPEGLYLATVADDRLLRIWALELKT-PIAFAPMTNGLCCTFFPHGGVIA 349
V + +A D + R+ + +T I + CC PH IA
Sbjct: 881 VMV-----------------LAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 923
Query: 350 TGTRDGHVQ 358
G +G ++
Sbjct: 924 FGDENGAIE 932
Score = 77.0 bits (188), Expect = 3e-14
Identities = 51/183 (27%), Positives = 85/183 (46%), Gaps = 8/183 (4%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
L + +D +I++W Q + L GHQ+ V+D + L+ S S D T+++W++
Sbjct: 964 LISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL--SWSFDGTVKVWNIIT 1020
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
K+ + H V C IS D + S + +K+ +WS + +L GH V
Sbjct: 1021 GNKEKDFVC-HQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCS 1079
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
FS DS LL T + + +W+ GE L H + + + H + +CFSP+G
Sbjct: 1080 AFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSEEGAATHGGWVTDLCFSPDG 1135
Query: 306 LYL 308
L
Sbjct: 1136 KML 1138
Score = 76.6 bits (187), Expect = 4e-14
Identities = 57/209 (27%), Positives = 92/209 (44%), Gaps = 28/209 (13%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSG-SLILVSASRDKTLRIWDLN 184
+AT D ++KIW TG L+ H + V FT S L+L + S D L++WDLN
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
Query: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKL--------- 235
+ + + GH V C SPD +L S + + ++ LW S + +
Sbjct: 721 QKECR-NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 779
Query: 236 ----EGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDV 291
E + V C +S D A ++ A+ + +W +T + D
Sbjct: 780 EDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLW------------NTDSRSKVADCRG 826
Query: 292 HISSLRSVCFSPEGLYLATVADDRLLRIW 320
H+S + V FSP+G T +DD+ +R+W
Sbjct: 827 HLSWVHGVMFSPDGSSFLTSSDDQTIRLW 855
Score = 63.9 bits (154), Expect = 2e-10
Identities = 45/173 (26%), Positives = 77/173 (44%), Gaps = 12/173 (6%)
Query: 192 VLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDS 251
V+ H VY S D + S +K++ ++ + + +++ H+ V+ C FS D
Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
Query: 252 ALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATV 311
+ T S D V +W+ TGE L HT + + + H ++ S L LAT
Sbjct: 659 RFIATCSVDKKVKIWNSMTGE----LVHTYDEHSEQVNCCHFTN------SSHHLLLATG 708
Query: 312 ADDRLLRIWALELK--TPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTA 362
+ D L++W L K F + C F P ++A+ + DG ++ W A
Sbjct: 709 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 761
Score = 59.3 bits (142), Expect = 6e-09
Identities = 59/306 (19%), Positives = 115/306 (37%), Gaps = 69/306 (22%)
Query: 134 QIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK-------- 185
+I +W + + + GH V + F+P GS L S S D+T+R+W+ K
Sbjct: 809 KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS-SDDQTIRLWETKKVCKNSAVM 867
Query: 186 --------------------HGKQIQVLSGHL--------QWVYCCSISPDCSMLCSAAG 217
H +++Q+++G V CC +SP +
Sbjct: 868 LKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDE 927
Query: 218 EKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD---------- 267
++ + + + + + H+ +V F+ D L+++S D + +W+
Sbjct: 928 NGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR 987
Query: 268 --PYTGERLRSLHHTQVDPAMDDSDV----------------HISSLRSVCFSPEGLYLA 309
T + R L ++++ D V H ++ S S + +
Sbjct: 988 GHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFS 1047
Query: 310 TVADDRLLRIWALELKTPIAFAPMTNGL--CCTFFPHGGVIATGTRDGHVQFWTAPRVLS 367
+ + D+ +IW+ +L P+ NG C F ++ATG +G ++ W
Sbjct: 1048 STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN--G 1105
Query: 368 SLKHLC 373
L HLC
Sbjct: 1106 ELLHLC 1111
Score = 53.9 bits (128), Expect = 3e-07
Identities = 62/247 (25%), Positives = 110/247 (44%), Gaps = 32/247 (12%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
+A G +G I+I E+ + + H+ V + FT + L+S+S D +++W N
Sbjct: 922 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFT-ADEKTLISSSDDAEIQVW--NW 978
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
+ L GH + V + + S L S + + +V +W++ + + HQ +V+SC
Sbjct: 979 QLDKCIFLRGHQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1037
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
D S D+ + S D +W + + L LH + H +R FS +
Sbjct: 1038 DISHDATKFSSTSADKTAKIW---SFDLLLPLHELRG---------HNGCVRCSAFSVDS 1085
Query: 306 LYLATVADDRLLRIW------ALELKTPIA-FAPMTNG-----LCCTFFPHGGVIATGTR 353
LAT D+ +RIW L L P++ T+G LC F P G ++ +
Sbjct: 1086 TLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC--FSPDGKMLISA-- 1141
Query: 354 DGHVQFW 360
G++++W
Sbjct: 1142 GGYIKWW 1148
Score = 36.2 bits (82), Expect = 0.054
Identities = 22/57 (38%), Positives = 32/57 (56%), Gaps = 8/57 (14%)
Query: 121 VSCLVLATGLNDGQIKIWEVQTGLLL-----LNLSG---HQDVVRDLSFTPSGSLIL 169
V +LATG ++G+I+IW V G LL L+ G H V DL F+P G +++
Sbjct: 1083 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1139
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 84.7 bits (208), Expect = 1e-16
Identities = 65/241 (26%), Positives = 109/241 (45%), Gaps = 47/241 (19%)
Query: 28 ETWSVAFSPDGSWFAWSQGHCIVKLIPWPLEEQFIPKGFEAKSRSSKNETKGRGSPKEKT 87
+ W++AFSPD + A G + K+ + +E KE +
Sbjct: 108 DAWTLAFSPDSQYLA--TGTHVGKVNIFGVES----------------------GKKEYS 143
Query: 88 LDC-GQIVWGLAFSPWPSPPSRKLWARHHPQVPDVSCLVLATGLNDGQIKIWEVQTGLLL 146
LD G+ + +A+SP LA+G DG I I+++ TG LL
Sbjct: 144 LDTRGKFILSIAYSP--------------------DGKYLASGAIDGIINIFDIATGKLL 183
Query: 147 LNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSIS 206
L GH +R L+F+P L LV+AS D ++I+D+ +H LSGH WV +
Sbjct: 184 HTLEGHAMPIRSLTFSPDSQL-LVTASDDGYIKIYDV-QHANLAGTLSGHASWVLNVAFC 241
Query: 207 PDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMW 266
PD + S++ +KSV +W + + T + HQ V ++ + + +V+ D + ++
Sbjct: 242 PDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
Query: 267 D 267
D
Sbjct: 302 D 302
Score = 79.7 bits (195), Expect = 4e-15
Identities = 62/236 (26%), Positives = 108/236 (45%), Gaps = 35/236 (14%)
Query: 86 KTLDCGQI-VWGLAFSPWPSPPSRKLWARHHPQVPDVSCLVLATGLNDGQIKIWEVQTGL 144
K++D G + W LAFSP LATG + G++ I+ V++G
Sbjct: 100 KSIDAGPVDAWTLAFSP--------------------DSQYLATGTHVGKVNIFGVESGK 139
Query: 145 LLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCS 204
+L + ++++P G L S + D + I+D+ GK + L GH + +
Sbjct: 140 KEYSLDTRGKFILSIAYSPDGKY-LASGAIDGIINIFDIAT-GKLLHTLEGHAMPIRSLT 197
Query: 205 ISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVI 264
SPD +L +A+ + + ++ ++ L L GH S V++ F PD V++S D +V
Sbjct: 198 FSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVK 257
Query: 265 MWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIW 320
+WD T R+ HT D H + V ++ G + +V DD+ + I+
Sbjct: 258 VWDVGT----RTCVHTFFD--------HQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
Score = 68.9 bits (167), Expect = 8e-12
Identities = 56/202 (27%), Positives = 97/202 (48%), Gaps = 20/202 (9%)
Query: 126 LATGLNDGQIKIWEVQTGLLLL--NLSGHQ--DVVRDLSFTPSGSLILVSASRDKTLRIW 181
+ TG D +K+W+ + L L +L GHQ V D+S T I S+S D +R+W
Sbjct: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLP---IAASSSLDAHIRLW 91
Query: 182 DLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSS 241
DL ++GKQI+ + + + SPD L + V ++ + S L+
Sbjct: 92 DL-ENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF 150
Query: 242 VVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCF 301
++S +SPD L + + D + ++D TG+ L +L + H +RS+ F
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL------------EGHAMPIRSLTF 198
Query: 302 SPEGLYLATVADDRLLRIWALE 323
SP+ L T +DD ++I+ ++
Sbjct: 199 SPDSQLLVTASDDGYIKIYDVQ 220
Score = 67.4 bits (163), Expect = 2e-11
Identities = 52/220 (23%), Positives = 101/220 (45%), Gaps = 24/220 (10%)
Query: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
+ A+ D I++W+++ G + ++ L+F+P S L + + + I+ +
Sbjct: 78 IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPD-SQYLATGTHVGKVNIFGVE 136
Query: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
GK+ L +++ + SPD L S A + + ++ + + L+ LEGH + S
Sbjct: 137 S-GKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRS 195
Query: 245 CDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPE 304
FSPDS LLVTAS D + ++D + H + + H S + +V F P+
Sbjct: 196 LTFSPDSQLLVTASDDGYIKIYD---------VQHANLAGTLSG---HASWVLNVAFCPD 243
Query: 305 GLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPH 344
+ + + D+ +++W + +T + TFF H
Sbjct: 244 DTHFVSSSSDKSVKVWDVGTRTCVH----------TFFDH 273
Score = 50.4 bits (119), Expect = 3e-06
Identities = 39/143 (27%), Positives = 64/143 (44%), Gaps = 16/143 (11%)
Query: 221 VFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHT 280
V+ W L LEGHQ VVS D S + ++S D ++ +WD G++++S+
Sbjct: 46 VWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAG 105
Query: 281 QVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNG---L 337
VD ++ FSP+ YLAT + I+ +E ++ T G L
Sbjct: 106 PVD------------AWTLAFSPDSQYLATGTHVGKVNIFGVE-SGKKEYSLDTRGKFIL 152
Query: 338 CCTFFPHGGVIATGTRDGHVQFW 360
+ P G +A+G DG + +
Sbjct: 153 SIAYSPDGKYLASGAIDGIINIF 175
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 83.6 bits (205), Expect = 3e-16
Identities = 68/241 (28%), Positives = 111/241 (46%), Gaps = 29/241 (12%)
Query: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
++ +G D +K+W +TG + L GH VR + +VS SRD TLR+WD+
Sbjct: 315 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR---VVSGSRDATLRVWDI- 370
Query: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
+ G+ + VL GH+ V C + D + S A + V +W + T + L+GH + V S
Sbjct: 371 ETGQCLHVLMGHVAAVRC--VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS 428
Query: 245 CDFSPDSALLVTASYDTNVIMWDPYTGERLRSL-HHTQVDPAMDDSDVHISSLRSVCFSP 303
F D +V+ S DT++ +WD TG + +L H + M+ D + S +
Sbjct: 429 LQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNA----- 481
Query: 304 EGLYLATVADDRLLRIWALE----LKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQF 359
D ++IW ++ L+T + + C F VI T + DG V+
Sbjct: 482 ----------DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI-TSSDDGTVKL 530
Query: 360 W 360
W
Sbjct: 531 W 531
Score = 75.5 bits (184), Expect = 8e-14
Identities = 68/284 (23%), Positives = 119/284 (41%), Gaps = 41/284 (14%)
Query: 96 GLAFSPWPSPPSRKL-----WARHHPQVPDV---------SCLV-----LATGLNDGQIK 136
G SPW S R+ W R + P V +CL + +G +D +K
Sbjct: 227 GFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLK 286
Query: 137 IWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGH 196
+W TG L L GH V + I++S S D+TL++W+ + G+ I L GH
Sbjct: 287 VWSAVTGKCLRTLVGHTGGVWSSQMRDN---IIISGSTDRTLKVWNA-ETGECIHTLYGH 342
Query: 197 LQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVT 256
V C + + S + + ++ +W + + + L GH ++V + D +V+
Sbjct: 343 TSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVS 398
Query: 257 ASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRL 316
+YD V +WDP T L +L H + + S+ F +G+++ + + D
Sbjct: 399 GAYDFMVKVWDPETETCLHTLQG------------HTNRVYSLQF--DGIHVVSGSLDTS 444
Query: 317 LRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 360
+R+W +E I L ++ +G D V+ W
Sbjct: 445 IRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIW 488
Score = 71.2 bits (173), Expect = 2e-12
Identities = 46/155 (29%), Positives = 81/155 (52%), Gaps = 11/155 (7%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
+ +G D +K+W+ +T L L GH + V L F + +VS S D ++R+WD+
Sbjct: 396 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD---GIHVVSGSLDTSIRVWDVET 452
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEG---HQSSV 242
G I L+GH + + +L S + +V +W +++ ++ L+G HQS+V
Sbjct: 453 -GNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 509
Query: 243 VSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSL 277
F+ + ++T+S D V +WD TGE +R+L
Sbjct: 510 TCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 542
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 83.6 bits (205), Expect = 3e-16
Identities = 68/241 (28%), Positives = 111/241 (46%), Gaps = 29/241 (12%)
Query: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
++ +G D +K+W +TG + L GH VR + +VS SRD TLR+WD+
Sbjct: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR---VVSGSRDATLRVWDI- 488
Query: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
+ G+ + VL GH+ V C + D + S A + V +W + T + L+GH + V S
Sbjct: 489 ETGQCLHVLMGHVAAVRC--VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS 546
Query: 245 CDFSPDSALLVTASYDTNVIMWDPYTGERLRSL-HHTQVDPAMDDSDVHISSLRSVCFSP 303
F D +V+ S DT++ +WD TG + +L H + M+ D + S +
Sbjct: 547 LQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNA----- 599
Query: 304 EGLYLATVADDRLLRIWALE----LKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQF 359
D ++IW ++ L+T + + C F VI T + DG V+
Sbjct: 600 ----------DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI-TSSDDGTVKL 648
Query: 360 W 360
W
Sbjct: 649 W 649
Score = 75.5 bits (184), Expect = 8e-14
Identities = 68/284 (23%), Positives = 119/284 (41%), Gaps = 41/284 (14%)
Query: 96 GLAFSPWPSPPSRKL-----WARHHPQVPDV---------SCLV-----LATGLNDGQIK 136
G SPW S R+ W R + P V +CL + +G +D +K
Sbjct: 345 GFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLK 404
Query: 137 IWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGH 196
+W TG L L GH V + I++S S D+TL++W+ + G+ I L GH
Sbjct: 405 VWSAVTGKCLRTLVGHTGGVWSSQMRDN---IIISGSTDRTLKVWNA-ETGECIHTLYGH 460
Query: 197 LQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVT 256
V C + + S + + ++ +W + + + L GH ++V + D +V+
Sbjct: 461 TSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVS 516
Query: 257 ASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRL 316
+YD V +WDP T L +L H + + S+ F +G+++ + + D
Sbjct: 517 GAYDFMVKVWDPETETCLHTLQG------------HTNRVYSLQF--DGIHVVSGSLDTS 562
Query: 317 LRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 360
+R+W +E I L ++ +G D V+ W
Sbjct: 563 IRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIW 606
Score = 71.2 bits (173), Expect = 2e-12
Identities = 46/155 (29%), Positives = 81/155 (52%), Gaps = 11/155 (7%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
+ +G D +K+W+ +T L L GH + V L F + +VS S D ++R+WD+
Sbjct: 514 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD---GIHVVSGSLDTSIRVWDVET 570
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEG---HQSSV 242
G I L+GH + + +L S + +V +W +++ ++ L+G HQS+V
Sbjct: 571 -GNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 627
Query: 243 VSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSL 277
F+ + ++T+S D V +WD TGE +R+L
Sbjct: 628 TCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 660
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 83.6 bits (205), Expect = 3e-16
Identities = 68/241 (28%), Positives = 111/241 (46%), Gaps = 29/241 (12%)
Query: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
++ +G D +K+W +TG + L GH VR + +VS SRD TLR+WD+
Sbjct: 353 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR---VVSGSRDATLRVWDI- 408
Query: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
+ G+ + VL GH+ V C + D + S A + V +W + T + L+GH + V S
Sbjct: 409 ETGQCLHVLMGHVAAVRC--VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS 466
Query: 245 CDFSPDSALLVTASYDTNVIMWDPYTGERLRSL-HHTQVDPAMDDSDVHISSLRSVCFSP 303
F D +V+ S DT++ +WD TG + +L H + M+ D + S +
Sbjct: 467 LQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNA----- 519
Query: 304 EGLYLATVADDRLLRIWALE----LKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQF 359
D ++IW ++ L+T + + C F VI T + DG V+
Sbjct: 520 ----------DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI-TSSDDGTVKL 568
Query: 360 W 360
W
Sbjct: 569 W 569
Score = 75.5 bits (184), Expect = 8e-14
Identities = 68/284 (23%), Positives = 119/284 (41%), Gaps = 41/284 (14%)
Query: 96 GLAFSPWPSPPSRKL-----WARHHPQVPDV---------SCLV-----LATGLNDGQIK 136
G SPW S R+ W R + P V +CL + +G +D +K
Sbjct: 265 GFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLK 324
Query: 137 IWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGH 196
+W TG L L GH V + I++S S D+TL++W+ + G+ I L GH
Sbjct: 325 VWSAVTGKCLRTLVGHTGGVWSSQMRDN---IIISGSTDRTLKVWNA-ETGECIHTLYGH 380
Query: 197 LQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVT 256
V C + + S + + ++ +W + + + L GH ++V + D +V+
Sbjct: 381 TSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVS 436
Query: 257 ASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRL 316
+YD V +WDP T L +L H + + S+ F +G+++ + + D
Sbjct: 437 GAYDFMVKVWDPETETCLHTLQG------------HTNRVYSLQF--DGIHVVSGSLDTS 482
Query: 317 LRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 360
+R+W +E I L ++ +G D V+ W
Sbjct: 483 IRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIW 526
Score = 71.2 bits (173), Expect = 2e-12
Identities = 46/155 (29%), Positives = 81/155 (52%), Gaps = 11/155 (7%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
+ +G D +K+W+ +T L L GH + V L F + +VS S D ++R+WD+
Sbjct: 434 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD---GIHVVSGSLDTSIRVWDVET 490
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEG---HQSSV 242
G I L+GH + + +L S + +V +W +++ ++ L+G HQS+V
Sbjct: 491 -GNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 547
Query: 243 VSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSL 277
F+ + ++T+S D V +WD TGE +R+L
Sbjct: 548 TCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 580
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 82.8 bits (203), Expect = 5e-16
Identities = 65/249 (26%), Positives = 100/249 (40%), Gaps = 23/249 (9%)
Query: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLIL-------VSASRDKT 177
+LAT G K+W V LL L GH V + F P ++ L S + D +
Sbjct: 245 MLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGS 304
Query: 178 LRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEG 237
+++W L+ + + + GH V P L + ++S LW + + I EG
Sbjct: 305 VKLWSLDSD-EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEG 363
Query: 238 HQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLR 297
H V F D +L T D +WD TG + L + H+ +
Sbjct: 364 HSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL------------EGHLKEIY 411
Query: 298 SVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLC--CTFFP-HGGVIATGTRD 354
+ FSP G ++AT + D ++W L + + P L F P HG + TG D
Sbjct: 412 GINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYD 471
Query: 355 GHVQFWTAP 363
+ WT P
Sbjct: 472 NTAKIWTHP 480
Score = 76.3 bits (186), Expect = 5e-14
Identities = 51/199 (25%), Positives = 90/199 (45%), Gaps = 15/199 (7%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
L T D ++W+++ +L+ GH V D++F GSL + D R+WDL +
Sbjct: 338 LGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLA-GTGGLDAFGRVWDL-R 395
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
G+ I L GHL+ +Y + SP+ + + +G+ + +W +R + + HQ+ V
Sbjct: 396 TGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGV 455
Query: 246 DFSP-DSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPE 304
F P L+T +YD +W L++L H + + S +
Sbjct: 456 KFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAG------------HEGKVMGLDISSD 503
Query: 305 GLYLATVADDRLLRIWALE 323
G +AT + DR ++W E
Sbjct: 504 GQLIATCSYDRTFKLWMAE 522
Score = 53.5 bits (127), Expect = 3e-07
Identities = 42/160 (26%), Positives = 60/160 (37%), Gaps = 6/160 (3%)
Query: 203 CSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTN 262
C SP+ ML +A LWS+ L+ L GH ++V + F P S T S D
Sbjct: 237 CHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKS----TVSLDPK 292
Query: 263 VIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWAL 322
+ + L D + D + H + V + P G +L T DR R+W L
Sbjct: 293 DVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352
Query: 323 ELKTPIAF--APMTNGLCCTFFPHGGVIATGTRDGHVQFW 360
E + I F G + TG D + W
Sbjct: 353 EAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVW 392
Score = 39.3 bits (90), Expect = 0.006
Identities = 30/107 (28%), Positives = 49/107 (45%), Gaps = 8/107 (7%)
Query: 225 SMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSL--HHTQV 282
S+RS G + C FSP+S +L TA + +W L +L H+T V
Sbjct: 217 SLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNV 276
Query: 283 DPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIA 329
+ H S +V P+ + LA+ A D +++W+L+ P+A
Sbjct: 277 GAIV----FHPKS--TVSLDPKDVNLASCAADGSVKLWSLDSDEPVA 317
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 82.4 bits (202), Expect = 7e-16
Identities = 45/153 (29%), Positives = 83/153 (54%), Gaps = 9/153 (5%)
Query: 120 DVSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLR 179
D S +++ G+ D IK+W+++ L + GH D V LS + GS +L +A D T+R
Sbjct: 203 DTSDQIISGGI-DNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM-DNTVR 260
Query: 180 IWDLNKHGKQ---IQVLSGHL----QWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLI 232
+WD+ + +++ G++ + + CS SPD S + + + ++ V++W S ++
Sbjct: 261 VWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL 320
Query: 233 RKLEGHQSSVVSCDFSPDSALLVTASYDTNVIM 265
KL GH S+ F PD ++++AS D + M
Sbjct: 321 YKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
Score = 79.7 bits (195), Expect = 4e-15
Identities = 74/271 (27%), Positives = 113/271 (41%), Gaps = 53/271 (19%)
Query: 146 LLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSI 205
++ LSGH+ V F P+GS L SA D+ + +W++ L GH V
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGST-LASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117
Query: 206 SPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC-DFSPDSALLVTASYDTNVI 264
+ D SML SA+ +K+V +W + +++L+GH S V SC L+ T S D V
Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177
Query: 265 MWDPYTGERLRSLHHT-------------QVDPAMDDSDV----------------HISS 295
+WD +++ +T Q+ D+D+ H S
Sbjct: 178 LWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADS 237
Query: 296 LRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPM---------------TNGLCCT 340
+ + S EG YL + A D +R+W + FAP N L C+
Sbjct: 238 VTGLSLSSEGSYLLSNAMDNTVRVWDVR-----PFAPKERCVKIFQGNVHNFEKNLLRCS 292
Query: 341 FFPHGGVIATGTRDGHVQFW--TAPRVLSSL 369
+ P G IA G+ D V W T+ R+L L
Sbjct: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKL 323
Score = 65.5 bits (158), Expect = 8e-11
Identities = 45/198 (22%), Positives = 84/198 (42%), Gaps = 10/198 (5%)
Query: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
+L + D + +W+ +TG + L GH V G ++ + S D T+++WD+
Sbjct: 123 MLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIR 182
Query: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
K IQ Q V + + + S + + +W +R L + GH SV
Sbjct: 183 KKA-AIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240
Query: 245 CDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVH--ISSLRSVCFS 302
S + + L++ + D V +WD +R + + +VH +L +S
Sbjct: 241 LSLSSEGSYLLSNAMDNTVRVWD------VRPFAPKERCVKIFQGNVHNFEKNLLRCSWS 294
Query: 303 PEGLYLATVADDRLLRIW 320
P+G +A + DR + +W
Sbjct: 295 PDGSKIAAGSADRFVYVW 312
Score = 49.3 bits (116), Expect = 6e-06
Identities = 35/162 (21%), Positives = 70/162 (43%), Gaps = 25/162 (15%)
Query: 232 IRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTG-ERLRSLHHTQVDPAMDDSD 290
I L GH+ V C F P+ + L +A +D +++W+ Y + +L
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKG----------- 107
Query: 291 VHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHGG---V 347
H ++ + ++ +G L + + D+ + +W E + + +P +
Sbjct: 108 -HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQL 166
Query: 348 IATGTRDGHVQFWTAPRVLSSLKHLCRKALRSFLTTYQVLAL 389
+ TG+ DG V+ W + + A+++F TYQVLA+
Sbjct: 167 VCTGSDDGTVKLWDIRK---------KAAIQTFQNTYQVLAV 199
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 82.4 bits (202), Expect = 7e-16
Identities = 67/229 (29%), Positives = 108/229 (47%), Gaps = 21/229 (9%)
Query: 133 GQIKIWEVQTGL----LLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGK 188
G+ ++W+V GL +LL GH D + D F PSG L ++S D T+++WDL K G
Sbjct: 371 GEDRLWKV-LGLPKCNVLLTGFGHTDWLSDCCFHPSGDK-LATSSGDTTVKLWDLCK-GD 427
Query: 189 QIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFS 248
I GH + V+ C+ + + S++ +K+ +W + S L GH SV S +F
Sbjct: 428 CILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFF 487
Query: 249 PDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYL 308
P S L+T+S D + +WD TG +SL+ H+ S+ F P G +
Sbjct: 488 PFSNTLLTSSADKTLSIWDARTGICEQSLYG------------HMHSINDAIFDPRGHMI 535
Query: 309 ATVADDRLLRIWALELKTPIAFAPM--TNGLCCTFFPHGGVIATGTRDG 355
A+ + ++W PI + + G F G V+A + +G
Sbjct: 536 ASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNG 584
Score = 68.6 bits (166), Expect = 1e-11
Identities = 56/237 (23%), Positives = 98/237 (41%), Gaps = 15/237 (6%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
LAT D +K+W++ G +L GH V ++ G+ + S+S DKT +IWD+N
Sbjct: 409 LATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV-ASSSLDKTSKIWDVNS 467
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSC 245
+ L GH V P + L +++ +K++ +W R+ + L GH S+
Sbjct: 468 ERCRC-TLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDA 526
Query: 246 DFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEG 305
F P ++ + +WD +L + + P S V F G
Sbjct: 527 IFDPRGHMIASCDACGVTKLWD---FRKLLPIVSIDIGP---------SPGNEVNFDSSG 574
Query: 306 LYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHGG-VIATGTRDGHVQFWT 361
LA + + ++ + L+ N F H G ++ +G DG V+ W+
Sbjct: 575 RVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
Score = 42.0 bits (97), Expect = 0.001
Identities = 36/167 (21%), Positives = 66/167 (39%), Gaps = 18/167 (10%)
Query: 200 VYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASY 259
V C S+ P +L S ++ + + ++ GH + C F P L T+S
Sbjct: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414
Query: 260 DTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRI 319
DT V +WD G+ + + + H ++ S + G ++A+ + D+ +I
Sbjct: 415 DTTVKLWDLCKGDCILTF------------EGHSRAVWSCTWHSCGNFVASSSLDKTSKI 462
Query: 320 WALELK----TPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTA 362
W + + T N + FFP + T + D + W A
Sbjct: 463 WDVNSERCRCTLYGHTDSVNSI--EFFPFSNTLLTSSADKTLSIWDA 507
>gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]
Length = 919
Score = 81.3 bits (199), Expect = 1e-15
Identities = 48/196 (24%), Positives = 95/196 (48%), Gaps = 14/196 (7%)
Query: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
+ TG +DG++K+W +G + + H V ++FT +G ++V++S D T+R +DL++
Sbjct: 388 IVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATG-YVVVTSSMDGTVRAFDLHR 446
Query: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEK-SVFLWSMRSYTLIRKLEGHQSSVVS 244
+ S C ++ ++ + A + +F+WSM++ L+ L GH+ +
Sbjct: 447 YRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISG 506
Query: 245 CDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPE 304
F+P ++L +AS+D V +WD + R + ++ S +V F P+
Sbjct: 507 LCFNPMKSVLASASWDKTVRLWDMFDSWRTK------------ETLALTSDALAVTFRPD 554
Query: 305 GLYLATVADDRLLRIW 320
G LA + + W
Sbjct: 555 GAELAVATLNSQITFW 570
Score = 63.2 bits (152), Expect = 4e-10
Identities = 58/270 (21%), Positives = 103/270 (38%), Gaps = 35/270 (12%)
Query: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
+L TG G + E+ L+ +LS + ++ SG I S L +W+
Sbjct: 302 LLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQ 361
Query: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
++ GH + + SPD + + + V +W+ S H S V
Sbjct: 362 SESYVLKQ-QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTG 420
Query: 245 CDFSPDSALLVTASYDTNVIMWD--------PYTGERLRSLHHTQVDP--------AMDD 288
F+ ++VT+S D V +D +T R VD A D
Sbjct: 421 VTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDS 480
Query: 289 SDVHISSLRS----------------VCFSPEGLYLATVADDRLLRIWAL--ELKTPIAF 330
++ + S+++ +CF+P LA+ + D+ +R+W + +T
Sbjct: 481 FEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETL 540
Query: 331 APMTNGLCCTFFPHGGVIATGTRDGHVQFW 360
A ++ L TF P G +A T + + FW
Sbjct: 541 ALTSDALAVTFRPDGAELAVATLNSQITFW 570
Score = 55.1 bits (131), Expect = 1e-07
Identities = 37/119 (31%), Positives = 57/119 (47%), Gaps = 3/119 (2%)
Query: 120 DVSCLVLATGLNDG-QIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTL 178
D S +++ G D +I +W +QTG LL LSGH+ + L F P S +L SAS DKT+
Sbjct: 467 DASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKS-VLASASWDKTV 525
Query: 179 RIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEG 237
R+WD+ + + L+ + PD + L A + W + +EG
Sbjct: 526 RLWDMFDSWRTKETLA-LTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEG 583
Score = 30.4 bits (67), Expect = 3.0
Identities = 20/70 (28%), Positives = 31/70 (44%), Gaps = 7/70 (10%)
Query: 213 CSAAGEKSVFLWSMRSYT----LIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD- 267
C G K + W + + L GH+ ++V+C F +S L + S D + MW
Sbjct: 158 CFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQC 217
Query: 268 --PYTGERLR 275
P G RL+
Sbjct: 218 DTPPEGLRLK 227
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.443
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,453,791
Number of Sequences: 37866
Number of extensions: 820531
Number of successful extensions: 4791
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 247
Number of HSP's successfully gapped in prelim test: 93
Number of HSP's that attempted gapping in prelim test: 1856
Number of HSP's gapped (non-prelim): 1492
length of query: 404
length of database: 18,247,518
effective HSP length: 105
effective length of query: 299
effective length of database: 14,271,588
effective search space: 4267204812
effective search space used: 4267204812
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.