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Search of human proteins with 89111135
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
(1359 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 2683 0.0
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 1277 0.0
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 1277 0.0
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 1203 0.0
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 1150 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 758 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 720 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 697 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 668 0.0
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 622 e-178
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 615 e-175
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 609 e-174
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 595 e-170
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 584 e-166
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 583 e-166
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 582 e-166
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 575 e-163
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 567 e-161
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 558 e-158
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 439 e-123
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 429 e-119
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 280 7e-75
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 240 8e-63
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 223 7e-58
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 189 2e-47
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 167 5e-41
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 152 3e-36
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 149 2e-35
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 149 2e-35
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 148 4e-35
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 2683 bits (6954), Expect = 0.0
Identities = 1359/1359 (100%), Positives = 1359/1359 (100%)
Query: 1 MVGEGPYLISDLDQRGRRRSFAERYDPSLKTMIPVRPCARLAPNPVDDAGLLSFATFSWL 60
MVGEGPYLISDLDQRGRRRSFAERYDPSLKTMIPVRPCARLAPNPVDDAGLLSFATFSWL
Sbjct: 1 MVGEGPYLISDLDQRGRRRSFAERYDPSLKTMIPVRPCARLAPNPVDDAGLLSFATFSWL 60
Query: 61 TPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQR 120
TPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQR
Sbjct: 61 TPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQR 120
Query: 121 TRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFW 180
TRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFW
Sbjct: 121 TRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFW 180
Query: 181 ALAWAINYRTAIRLKVALSTLVFENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPL 240
ALAWAINYRTAIRLKVALSTLVFENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPL
Sbjct: 181 ALAWAINYRTAIRLKVALSTLVFENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPL 240
Query: 241 PATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQ 300
PATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQ
Sbjct: 241 PATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQ 300
Query: 301 TMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVL 360
TMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVL
Sbjct: 301 TMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVL 360
Query: 361 TLSCHILLRRKLTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSP 420
TLSCHILLRRKLTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSP
Sbjct: 361 TLSCHILLRRKLTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSP 420
Query: 421 PSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAK 480
PSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAK
Sbjct: 421 PSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAK 480
Query: 481 GATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVN 540
GATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVN
Sbjct: 481 GATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVN 540
Query: 541 GTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
GTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG
Sbjct: 541 GTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
Query: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH
Sbjct: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
Query: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVE 720
QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVE
Sbjct: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVE 720
Query: 721 AFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWK 780
AFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWK
Sbjct: 721 AFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWK 780
Query: 781 TYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVG 840
TYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVG
Sbjct: 781 TYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVG 840
Query: 841 AVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFF 900
AVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFF
Sbjct: 841 AVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFF 900
Query: 901 DTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAV 960
DTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAV
Sbjct: 901 DTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAV 960
Query: 961 GFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYHLLYFNC 1020
GFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYHLLYFNC
Sbjct: 961 GFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYHLLYFNC 1020
Query: 1021 ALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTET 1080
ALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTET
Sbjct: 1021 ALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTET 1080
Query: 1081 QAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSL 1140
QAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSL
Sbjct: 1081 QAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSL 1140
Query: 1141 NLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVI 1200
NLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVI
Sbjct: 1141 NLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVI 1200
Query: 1201 PQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVG 1260
PQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVG
Sbjct: 1201 PQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVG 1260
Query: 1261 ERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLN 1320
ERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLN
Sbjct: 1261 ERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLN 1320
Query: 1321 CDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEVRL 1359
CDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEVRL
Sbjct: 1321 CDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEVRL 1359
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 1277 bits (3305), Expect = 0.0
Identities = 650/1342 (48%), Positives = 894/1342 (66%), Gaps = 40/1342 (2%)
Query: 24 RYDPSLKTMIPVRPCARL-APNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLST 82
+YD +L+TMIP RP R AP P+D+AGL S+ T SWLTP+M++ R RL +T+PPLS
Sbjct: 63 KYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSV 122
Query: 83 YDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPV 142
+D+SD N +R LW+EEV+R G EKAS+ V+ +FQRTR++ D + I I + +GP+
Sbjct: 123 HDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPI 182
Query: 143 ILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLV 202
++I +IL+ +E G V G+GLC ALF +E K ++ +W IN RTAIR + A+S+
Sbjct: 183 LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFA 242
Query: 203 FENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPT 262
FE L+ FK++ HI+ GE ++ + D LFE + PL +V C+ ++FI+G T
Sbjct: 243 FEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYT 302
Query: 263 ALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFT 322
A I I Y++ P+ +FM ++ + V+D+R++ +E LTCI+LIKMY WEK F
Sbjct: 303 AFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFA 362
Query: 323 NTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIA 382
I+D+RR+ERKLLEK G VQS S I+ T+A + + H L+ KLTA +AFS++A
Sbjct: 363 KIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLA 422
Query: 383 MFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLT 442
N+++ S+ +P ++K + + ++ R KK + +SP Y+ +DP L+ ATL+
Sbjct: 423 SLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLS 482
Query: 443 WEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFV 502
W+ T + N L +R+ SE + A GPEE+ +SL LH I+ V
Sbjct: 483 WQQ------TCPGIVNGALEL---ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLV 533
Query: 503 VRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENIL 562
V KG +LG+CGN GSGKSSLL+A+L +M L +G V V G+LAYV QQAWI GN+RENIL
Sbjct: 534 VSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENIL 593
Query: 563 FGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQ 622
G YD RY + C L +DL LP+GD+TEIGERGLNLSGGQ+QRISLARAVYSDRQ
Sbjct: 594 MGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQ 653
Query: 623 LYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEK 682
+YLLDDPLSAVDAHVGKH+FEECIKKTLRGKTVVLVTHQLQ+LE C ++ILLE+G+ICE
Sbjct: 654 IYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICEN 713
Query: 683 GTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGN 742
GTH ELM+++G+YA+LI + KE+ ++ +D I P
Sbjct: 714 GTHSELMQKKGKYAQLIQKMH-------------------KEATSDMLQDTAKIAEKPKV 754
Query: 743 EKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLF 802
E + + VPEHQL Q E +EG+++W+ YH YI+A+GGY++S F
Sbjct: 755 ES-QALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFV 813
Query: 803 LLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFM 862
+L++ FS WWL WL++GS + N TM ++G + + YQ VY + + +
Sbjct: 814 VLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLL 873
Query: 863 LVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVR 922
+ GV +FTK T AS++LH+ +F+K+ + PMSFFDT P GRL+N F+ D+++LD
Sbjct: 874 ICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQL 933
Query: 923 LPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENV 982
LP +E FL MV+ +L+I++ + P +LL+ A + V FI +F + + K++EN
Sbjct: 934 LPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENY 993
Query: 983 SRSPWFTHITSSMQGLGIIHAYGKKESCITY----------HLLYFNCALRWFALRMDVL 1032
SRSP F+HI +S+QGL IH YGK E I+ +LL F + RW ALR++++
Sbjct: 994 SRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIM 1053
Query: 1033 MNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLRE 1092
N++T VAL V SS S K ++++ ++QL+ Q R G ET+A+FT+VE + +
Sbjct: 1054 TNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQ 1113
Query: 1093 YISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGI 1152
Y+ CV E ++ +CP+ WP GEI F+DY M+YRDNTP VL +NL I+ + VGI
Sbjct: 1114 YMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGI 1173
Query: 1153 VGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVR 1212
VGRTGSGKSSLGMALFRLVEP +G I ID VDIC + LEDLR+KL+VIPQDPVL GT+R
Sbjct: 1174 VGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIR 1233
Query: 1213 YNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALL 1272
+NLDPF+ HTD+ +W LERTF+ I K P+KL +V ENG NFSVGERQLLC+ARA+L
Sbjct: 1234 FNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVL 1293
Query: 1273 RNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKV 1332
RNSKIIL+DEATAS+D +TDTL+Q TI++AF+GCTVL IAHR+ TVLNCDH+LVM NGKV
Sbjct: 1294 RNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKV 1353
Query: 1333 IEFDKPEVLAEKPDSAFAMLLA 1354
+EFD+PEVL +KP S FA L+A
Sbjct: 1354 VEFDRPEVLRKKPGSLFAALMA 1375
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 1277 bits (3305), Expect = 0.0
Identities = 650/1342 (48%), Positives = 894/1342 (66%), Gaps = 40/1342 (2%)
Query: 24 RYDPSLKTMIPVRPCARL-APNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLST 82
+YD +L+TMIP RP R AP P+D+AGL S+ T SWLTP+M++ R RL +T+PPLS
Sbjct: 63 KYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSV 122
Query: 83 YDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPV 142
+D+SD N +R LW+EEV+R G EKAS+ V+ +FQRTR++ D + I I + +GP+
Sbjct: 123 HDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPI 182
Query: 143 ILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLV 202
++I +IL+ +E G V G+GLC ALF +E K ++ +W IN RTAIR + A+S+
Sbjct: 183 LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFA 242
Query: 203 FENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPT 262
FE L+ FK++ HI+ GE ++ + D LFE + PL +V C+ ++FI+G T
Sbjct: 243 FEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYT 302
Query: 263 ALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFT 322
A I I Y++ P+ +FM ++ + V+D+R++ +E LTCI+LIKMY WEK F
Sbjct: 303 AFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFA 362
Query: 323 NTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIA 382
I+D+RR+ERKLLEK G VQS S I+ T+A + + H L+ KLTA +AFS++A
Sbjct: 363 KIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLA 422
Query: 383 MFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLT 442
N+++ S+ +P ++K + + ++ R KK + +SP Y+ +DP L+ ATL+
Sbjct: 423 SLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLS 482
Query: 443 WEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFV 502
W+ T + N L +R+ SE + A GPEE+ +SL LH I+ V
Sbjct: 483 WQQ------TCPGIVNGALEL---ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLV 533
Query: 503 VRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENIL 562
V KG +LG+CGN GSGKSSLL+A+L +M L +G V V G+LAYV QQAWI GN+RENIL
Sbjct: 534 VSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENIL 593
Query: 563 FGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQ 622
G YD RY + C L +DL LP+GD+TEIGERGLNLSGGQ+QRISLARAVYSDRQ
Sbjct: 594 MGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQ 653
Query: 623 LYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEK 682
+YLLDDPLSAVDAHVGKH+FEECIKKTLRGKTVVLVTHQLQ+LE C ++ILLE+G+ICE
Sbjct: 654 IYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICEN 713
Query: 683 GTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGN 742
GTH ELM+++G+YA+LI + KE+ ++ +D I P
Sbjct: 714 GTHSELMQKKGKYAQLIQKMH-------------------KEATSDMLQDTAKIAEKPKV 754
Query: 743 EKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLF 802
E + + VPEHQL Q E +EG+++W+ YH YI+A+GGY++S F
Sbjct: 755 ES-QALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFV 813
Query: 803 LLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFM 862
+L++ FS WWL WL++GS + N TM ++G + + YQ VY + + +
Sbjct: 814 VLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLL 873
Query: 863 LVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVR 922
+ GV +FTK T AS++LH+ +F+K+ + PMSFFDT P GRL+N F+ D+++LD
Sbjct: 874 ICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQL 933
Query: 923 LPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENV 982
LP +E FL MV+ +L+I++ + P +LL+ A + V FI +F + + K++EN
Sbjct: 934 LPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENY 993
Query: 983 SRSPWFTHITSSMQGLGIIHAYGKKESCITY----------HLLYFNCALRWFALRMDVL 1032
SRSP F+HI +S+QGL IH YGK E I+ +LL F + RW ALR++++
Sbjct: 994 SRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIM 1053
Query: 1033 MNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLRE 1092
N++T VAL V SS S K ++++ ++QL+ Q R G ET+A+FT+VE + +
Sbjct: 1054 TNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQ 1113
Query: 1093 YISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGI 1152
Y+ CV E ++ +CP+ WP GEI F+DY M+YRDNTP VL +NL I+ + VGI
Sbjct: 1114 YMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGI 1173
Query: 1153 VGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVR 1212
VGRTGSGKSSLGMALFRLVEP +G I ID VDIC + LEDLR+KL+VIPQDPVL GT+R
Sbjct: 1174 VGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIR 1233
Query: 1213 YNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALL 1272
+NLDPF+ HTD+ +W LERTF+ I K P+KL +V ENG NFSVGERQLLC+ARA+L
Sbjct: 1234 FNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVL 1293
Query: 1273 RNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKV 1332
RNSKIIL+DEATAS+D +TDTL+Q TI++AF+GCTVL IAHR+ TVLNCDH+LVM NGKV
Sbjct: 1294 RNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKV 1353
Query: 1333 IEFDKPEVLAEKPDSAFAMLLA 1354
+EFD+PEVL +KP S FA L+A
Sbjct: 1354 VEFDRPEVLRKKPGSLFAALMA 1375
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 1203 bits (3112), Expect = 0.0
Identities = 622/1342 (46%), Positives = 862/1342 (64%), Gaps = 78/1342 (5%)
Query: 24 RYDPSLKTMIPVRPCARL-APNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLST 82
+YD +L+TMIP RP R AP P+D+AGL S+ T SWLTP+M++ R RL +T+PPLS
Sbjct: 63 KYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSV 122
Query: 83 YDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPV 142
+D+SD N +R LW+EEV+R G EKAS+ V+ +FQRTR++ D + I I + +GP+
Sbjct: 123 HDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPI 182
Query: 143 ILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLV 202
++I +IL+ +E G V G+GLC ALF +E K ++ +W IN RTAIR + A+S+
Sbjct: 183 LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFA 242
Query: 203 FENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPT 262
FE L+ FK++ HI+ GE ++ + D LFE + PL +V C+ ++FI+G T
Sbjct: 243 FEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYT 302
Query: 263 ALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFT 322
A I I Y++ P+ +FM ++ + V+D+R++ +E LTCI+LIKMY WEK F
Sbjct: 303 AFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFA 362
Query: 323 NTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIA 382
I+D+RR+ERKLLEK G VQS S I+ T+A + + H L+ KLTA +AFS++A
Sbjct: 363 KIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLA 422
Query: 383 MFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLT 442
N+++ S+ +P ++K + + ++ R KK + +SP Y+ +DP L+ ATL+
Sbjct: 423 SLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLS 482
Query: 443 WEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFV 502
W+ T + N L +R+ SE + A GPEE+ +SL LH I+ V
Sbjct: 483 WQ------QTCPGIVNGALEL---ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLV 533
Query: 503 VRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENIL 562
V KG +LG+CGN GSGKSSLL+A+L +M L +G V V G+LAYV QQAWI GN+RENIL
Sbjct: 534 VSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENIL 593
Query: 563 FGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQ 622
G YD RY + C L +DL LP+GD+TEIGERGLNLSGGQ+QRISLARAVYSDRQ
Sbjct: 594 MGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQ 653
Query: 623 LYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEK 682
+YLLDDPLSAVDAHVGKH+FEECIKKTLRGKTVVLVTHQLQ+LE C ++ILLE+G+ICE
Sbjct: 654 IYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICEN 713
Query: 683 GTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGN 742
GTH ELM+++G+YA+LI + KE+ ++ +D I P
Sbjct: 714 GTHSELMQKKGKYAQLIQKMH-------------------KEATSDMLQDTAKIAEKPKV 754
Query: 743 EKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLF 802
E + + VPEHQL Q E +EG+++W+ YH YI+A+GGY++S F
Sbjct: 755 E-SQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFV 813
Query: 803 LLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFM 862
+L++ FS WWL WL++GS + N TM ++G + + YQ VY + + +
Sbjct: 814 VLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLL 873
Query: 863 LVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVR 922
+ GV +FTK T AS++LH+ +F+K+ + PMSFFDT P GRL+N F+ D+++LD
Sbjct: 874 ICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQL 933
Query: 923 LPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENV 982
LP +E FL MV+ +L+I++ + P +LL+ A + V FI +F + + K++EN
Sbjct: 934 LPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENY 993
Query: 983 SRSPWFTHITSSMQGLGIIHAYGKKESCITY----------HLLYFNCALRWFALRMDVL 1032
SRSP F+HI +S+QGL IH YGK E I+ +LL F + RW ALR++++
Sbjct: 994 SRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIM 1053
Query: 1033 MNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLRE 1092
N++T VAL V SS S K ++++ ++QL+ Q R G ET+A+FT+VE + +
Sbjct: 1054 TNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQ 1113
Query: 1093 YISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGI 1152
Y+ CV E ++ +CP+ WP GEI F+DY M+YRDNTP VL +NL I+ + VGI
Sbjct: 1114 YMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGI 1173
Query: 1153 VGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVR 1212
VGRTGSGKSSLGMALFRLVEP +G I ID VDIC + LEDLR+KL+VIPQDPVL GT+R
Sbjct: 1174 VGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIR 1233
Query: 1213 YNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALL 1272
+NLDPF+ HTD+ +W LERTF+
Sbjct: 1234 FNLDPFDRHTDQQIWDALERTFL------------------------------------- 1256
Query: 1273 RNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKV 1332
IIL+DEATAS+D +TDTL+Q TI++AF+GCTVL IAHR+ TVLNCDH+LVM NGKV
Sbjct: 1257 -TKAIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKV 1315
Query: 1333 IEFDKPEVLAEKPDSAFAMLLA 1354
+EFD+PEVL +KP S FA L+A
Sbjct: 1316 VEFDRPEVLRKKPGSLFAALMA 1337
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 1150 bits (2975), Expect = 0.0
Identities = 616/1373 (44%), Positives = 874/1373 (63%), Gaps = 62/1373 (4%)
Query: 24 RYDPSLKTMIPVRPCARLAPNPVDDAGLLSFATFSWLTPVMVKGYRQ-RLTVDTLPPLST 82
+Y L + P+R ++ +PVD+AGL S TFSWL+ + +++ L+++ + LS
Sbjct: 80 KYHHGLSALKPIRTTSK-HQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSK 138
Query: 83 YDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPV 142
++SSD N +R LW EE+ VGP+ ASL VVW F RTR+++ IV ++ + GP
Sbjct: 139 HESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPA 198
Query: 143 ILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLV 202
++ +L+ T+ T + + L + L TE + + AL WA+NYRT +RL+ A+ T+
Sbjct: 199 FMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMA 258
Query: 203 FENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPT 262
F+ ++ K + S+GE++NI S+D +FEAA L A P++ + Y ILGPT
Sbjct: 259 FKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPT 318
Query: 263 ALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFT 322
+G +V+++F P MF ++L + FRR + TD+RVQ MNE LT I+ IKMYAW K+F+
Sbjct: 319 GFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFS 378
Query: 323 NTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIA 382
++Q IR ER++LEKAG+ QS +APIV IA V+T S H+ L LTA AF+V+
Sbjct: 379 QSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVT 438
Query: 383 MFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLT 442
+FN M F++ + PFS+K+++EA+V++ R K + + + +P P + + NATL
Sbjct: 439 VFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLA 498
Query: 443 WEH-----EASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPA-----KG--------ATG 484
W+ + S K TPK ++++ KK++ A KG
Sbjct: 499 WDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPS 558
Query: 485 PEEQSDS--------LKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGV 536
PEE+ L+ LHSI +++GK++GICG+VGSGK+SL++A+LGQM L +G
Sbjct: 559 PEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGS 618
Query: 537 VAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEI 596
+A++GT AYV+QQAWI + +R+NILFG++YD +RY + C L+ DL+ LP DLTEI
Sbjct: 619 IAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEI 678
Query: 597 GERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVV 656
GERG NLSGGQRQRISLARA+YSDR +Y+LDDPLSA+DAHVG H+F I+K L+ KTV+
Sbjct: 679 GERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVL 738
Query: 657 LVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNA 716
VTHQLQ+L CDEVI +++G I E+GTH+ELM G YA + +NL L + P N+
Sbjct: 739 FVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNL--LLGETPPVEINS 796
Query: 717 AMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVD--TKVPEHQLIQTESPQE 774
++E +G +K + K +TGS + K E QL+Q E +
Sbjct: 797 ------------KKETSG------SQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQ 838
Query: 775 GTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNR 834
G+V W Y YI+A+GG L L + LF+L +GS AFS WWL W+ +GS T +GN
Sbjct: 839 GSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNE 898
Query: 835 TMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILK 894
T ++ + Y +Y SM ML+ +G VF K TL ASS LHD +F +IL+
Sbjct: 899 TSVS-DSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILR 957
Query: 895 SPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLV 954
SPM FFDTTPTGR++NRFSKDMDE+DVRLPF AE F+Q +V F + ++A VFP L+
Sbjct: 958 SPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVA 1017
Query: 955 VASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYH 1014
V L + F +L + ++ELK+++N+++SP+ +HITSS+QGL IHAY K + + +
Sbjct: 1018 VGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRY 1077
Query: 1015 ----------LLYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYII 1064
F CA+RW A+R+D++ L T L++ L I + GL++SY +
Sbjct: 1078 QELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAV 1137
Query: 1065 QLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITFRD 1124
QL+GL Q VR +ET+A+FTSVE + YI T E +K DWP GE+TF +
Sbjct: 1138 QLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFEN 1197
Query: 1125 YQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVD 1184
+MRYR+N PLVL ++ I+ + +GIVGRTGSGKSSLGMALFRLVE + G I ID V
Sbjct: 1198 AEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVR 1257
Query: 1185 ICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPE 1244
I + L DLR+KL++IPQ+PVLF GTVR NLDPF +T++ +W LERT M++ I +LP
Sbjct: 1258 ISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPL 1317
Query: 1245 KLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFK 1304
KL++EV ENG+NFSVGERQLLC+ARALLR+ KI++LDEATA+MD++TD L+Q TI++AF
Sbjct: 1318 KLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFA 1377
Query: 1305 GCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAF-AMLLAAE 1356
CT+LTIAHRL+TVL D ++V+ G+V+EFD P VL S F AM AAE
Sbjct: 1378 DCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAE 1430
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 758 bits (1958), Expect = 0.0
Identities = 465/1348 (34%), Positives = 735/1348 (54%), Gaps = 109/1348 (8%)
Query: 32 MIPVRPCARLAPNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAK 91
M+PV + PNP+ DA L S F WL P+ G+++RL D + + D S +
Sbjct: 1 MLPVYQ--EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
Query: 92 RFRVLWDEEVARV--GPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQIL 149
+ WD+EV R +K SL+ + K L+ + ++ I P+ L +I+
Sbjct: 59 ELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFL-GKII 117
Query: 150 QQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYR--------TAIRLKVALSTL 201
E V + A +AT T F L AI + +RL+VA+ +
Sbjct: 118 NYFENYDPMDSVALNTAYA-YATVLT---FCTLILAILHHLYFYHVQCAGMRLRVAMCHM 173
Query: 202 VFENLVSFKTLT--HISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFIL 259
++ + + + G+++N+LS+D + +F P+ + A + +
Sbjct: 174 IYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEI 233
Query: 260 GPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEK 319
G + L G++V +I +P+Q KL S+ R TD R++TMNE +T IR+IKMYAWEK
Sbjct: 234 GISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEK 293
Query: 320 SFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFS 379
SF+N I ++R++E + ++ ++ N A S I + +T + ++LL +TA F
Sbjct: 294 SFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFV 353
Query: 380 VIAMFNVMKFSIAIL-PFSIKAMAEANVSLRRMKK-ILIDKSPPSYITQPEDPDTVLLLA 437
+ ++ ++ ++ + P +I+ ++EA VS+RR++ +L+D+ P D ++ +
Sbjct: 354 AVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQ 413
Query: 438 NATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLH 497
+ T W+ +AS T L
Sbjct: 414 DFTAFWD-KASETPT-------------------------------------------LQ 429
Query: 498 SISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNV 557
+SF VR G++L + G VG+GKSSLL+A+LG++ G+V+V+G +AYVSQQ W+F G +
Sbjct: 430 GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTL 489
Query: 558 RENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAV 617
R NILFG+KY+ +RY+ ++ C L+KDL L GDLT IG+RG LSGGQ+ R++LARAV
Sbjct: 490 RSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAV 549
Query: 618 YSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDG 677
Y D +YLLDDPLSAVDA V +H+FE CI + L K +LVTHQLQ+L++ ++++L+DG
Sbjct: 550 YQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDG 609
Query: 678 EICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIV 737
++ +KGT+ E ++ + L+ + P F ES ++
Sbjct: 610 KMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQS----- 664
Query: 738 LAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLF 797
+ + KD ES+ +E V + E E+ EG V ++ Y Y +A ++
Sbjct: 665 -SRPSLKDGALESQ-DTENVPVTLSE------ENRSEGKVGFQAYKNYFRAGAHWI---- 712
Query: 798 TVFLFLLMIGSAA-----FSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQ 852
VF+FL+++ +AA +WWL W +K S + N T+ G V + + Y
Sbjct: 713 -VFIFLILLNTAAQVAYVLQDWWLSYWANKQSML------NVTVNGGGNVTEKLDLNWYL 765
Query: 853 WVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRF 912
+Y+ V ++FG+ + + + +S +LH+ +F+ ILK+P+ FFD P GR++NRF
Sbjct: 766 GIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRF 825
Query: 913 SKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRG 972
SKD+ LD LP +F+Q VV ++ + AV P + + + L + F L R F
Sbjct: 826 SKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLET 885
Query: 973 VQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESC----------ITYHLLYFNCAL 1022
+++K++E+ +RSP F+H++SS+QGL I AY +E C + F
Sbjct: 886 SRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTS 945
Query: 1023 RWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQA 1082
RWFA+R+D + + VA + ++ GL+LSY + L G+ Q CVR E +
Sbjct: 946 RWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVEN 1005
Query: 1083 KFTSVELLREYISTCVPECTHPLKVGTCPKD-WPSRGEITFRDYQMRYRDNTPLVLDSLN 1141
SVE + EY E P + P WP G I F + Y PLVL L
Sbjct: 1006 MMISVERVIEYTDL---EKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLT 1062
Query: 1142 LNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIP 1201
I+S + VGIVGRTG+GKSSL ALFRL EP G I+ID++ + L DLR K+++IP
Sbjct: 1063 ALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIP 1121
Query: 1202 QDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGE 1261
Q+PVLF GT+R NLDPF HTDE LW L+ +++TI LP K+ E+ E+G NFSVG+
Sbjct: 1122 QEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQ 1181
Query: 1262 RQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNC 1321
RQL+C+ARA+LR ++I+++DEATA++D +TD L+Q I++ F CTVLTIAHRLNT+++
Sbjct: 1182 RQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDS 1241
Query: 1322 DHVLVMENGKVIEFDKPEVLAEKPDSAF 1349
D ++V+++G++ E+D+P VL + +S F
Sbjct: 1242 DKIMVLDSGRLKEYDEPYVLLQNKESLF 1269
Score = 84.0 bits (206), Expect = 9e-16
Identities = 58/225 (25%), Positives = 118/225 (52%), Gaps = 22/225 (9%)
Query: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALL------GQMQLQK------GVVAVNGT 542
VL ++ +++ + +GI G G+GKSSL++AL G++ + K G+ +
Sbjct: 1057 VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKK 1116
Query: 543 LAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLN 602
++ + Q+ +F G +R+N+ ++ + + ++ L++ + +LP TE+ E G N
Sbjct: 1117 MSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSN 1176
Query: 603 LSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGK----TVVLV 658
S GQRQ + LARA+ Q+ ++D+ + VD +E I+K +R K TV+ +
Sbjct: 1177 FSVGQRQLVCLARAILRKNQILIIDEATANVDPRT-----DELIQKKIREKFAHCTVLTI 1231
Query: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEER-GRYAKLIHNL 702
H+L + D++++L+ G + E L++ + + K++ L
Sbjct: 1232 AHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQL 1276
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 720 bits (1859), Expect = 0.0
Identities = 456/1385 (32%), Positives = 726/1385 (52%), Gaps = 143/1385 (10%)
Query: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVA 102
P P A LS TF W+T ++V+GYRQ L L L+ D+S+ W +E A
Sbjct: 207 PCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECA 266
Query: 103 RV-----------------------------------GPEKA---SLSHVVWKFQRTRVL 124
+ P+K SL V++K L
Sbjct: 267 KTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFL 326
Query: 125 MDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAW 184
M + +M GP IL +++ T W G + LF T + +
Sbjct: 327 MSFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYF 385
Query: 185 AINYRTAIRLKVALSTLVFEN--LVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPA 242
I + + +R+K A+ V+ +++ +VGE++N++S D+ + A + +
Sbjct: 386 HICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIW 445
Query: 243 TIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTM 302
+ P+ ++ + LGP+ L G++V V+ +PV MA ++ + + D R++ M
Sbjct: 446 SAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLM 505
Query: 303 NEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTL 362
NE L I+++K+YAWE +F + + IR+ E K+L+K+ ++ + + + + T
Sbjct: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTF 565
Query: 363 SCHILLRRK--LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKS- 419
+ ++ + L A AF +A+FN+++F + ILP I ++ +A+VSL+R++ L +
Sbjct: 566 AVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEEL 625
Query: 420 -PPSYITQPEDPD---TVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSER 475
P S +P + + NAT TW +
Sbjct: 626 EPDSIERRPVKDGGGTNSITVRNATFTW-----------------------------ARS 656
Query: 476 SPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKG 535
PP L+ I+F + +G ++ + G VG GKSSLL+ALL +M +G
Sbjct: 657 DPPT----------------LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG 700
Query: 536 VVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTE 595
VA+ G++AYV QQAWI + ++RENILFG + + Y+ ++ C L DL LP GD TE
Sbjct: 701 HVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTE 760
Query: 596 IGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECI--KKTLRGK 653
IGE+G+NLSGGQ+QR+SLARAVYS+ +YL DDPLSAVDAHVGKH+FE I K L+ K
Sbjct: 761 IGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNK 820
Query: 654 TVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGL-QFKDPEH 712
T +LVTH + +L D +I++ G+I E G+++EL+ G +A+ + Q +D E
Sbjct: 821 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEE 880
Query: 713 LYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDT------------- 759
+ KE+ ++ + G++V ++ + + S + S D
Sbjct: 881 NGVTGVSGPGKEA---KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKA 937
Query: 760 ---KVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWL 816
K +L++ + Q G V Y Y+KA G ++ S ++FLF+ SA SN+WL
Sbjct: 938 EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFI-SFLSIFLFMCNHVSALASNYWL 996
Query: 817 GLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKT 876
LW D P N T L+ G + VF V+ G +
Sbjct: 997 SLWTDD-------PIVNGTQEHTKVRLSVYGA---LGISQGIAVFGYSMAVSIGGI---- 1042
Query: 877 TLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFM 936
+AS LH + IL+SPMSFF+ TP+G L+NRFSK++D +D +P + F+ F
Sbjct: 1043 --LASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFN 1100
Query: 937 VVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQ 996
V+ +++ P +++ L + +F + R + ++LK++E+VSRSP ++H ++
Sbjct: 1101 VIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLL 1160
Query: 997 GLGIIHAYGKKESCITYHLLYFN----------CALRWFALRMDVLMNILTFTVALLVTL 1046
G+ +I A+ ++E I L + A RW A+R++ + N + AL +
Sbjct: 1161 GVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1220
Query: 1047 SFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLK 1106
S S+S GLS+SY +Q++ L VR +E + +VE L+EY T E ++
Sbjct: 1221 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQ 1279
Query: 1107 VGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMA 1166
P WP G + FR+Y +RYR++ VL +N+ I G+ VGIVGRTG+GKSSL +
Sbjct: 1280 ETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLG 1339
Query: 1167 LFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEML 1226
LFR+ E A G I ID ++I + L DLR K+T+IPQDPVLF G++R NLDPF ++DE +
Sbjct: 1340 LFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEV 1399
Query: 1227 WQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATAS 1286
W LE ++D + LP+KL E E GEN SVG+RQL+C+ARALLR +KI++LDEATA+
Sbjct: 1400 WTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAA 1459
Query: 1287 MDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPD 1346
+D +TD L+Q+TI+ F+ CTVLTIAHRLNT+++ V+V++ G++ E+ P L ++
Sbjct: 1460 VDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1519
Query: 1347 SAFAM 1351
++M
Sbjct: 1520 LFYSM 1524
Score = 79.3 bits (194), Expect = 2e-14
Identities = 64/246 (26%), Positives = 114/246 (46%), Gaps = 19/246 (7%)
Query: 1112 KDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLV 1171
KD IT R+ + + P L+ + +I G V +VG+ G GKSSL AL +
Sbjct: 636 KDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEM 695
Query: 1172 EPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQ-VL 1230
+ G + I + + +PQ + ++R N+ F +E ++ V+
Sbjct: 696 DKVEGHVAI-------------KGSVAYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVI 741
Query: 1231 ERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSK 1290
+ + + LP + E+ E G N S G++Q + +ARA+ N+ I L D+ +++D+
Sbjct: 742 QACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAH 801
Query: 1291 TDT-LVQNTI--KDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDS 1347
+ +N I K K T + + H ++ + D ++VM GK+ E + L + D
Sbjct: 802 VGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DG 860
Query: 1348 AFAMLL 1353
AFA L
Sbjct: 861 AFAEFL 866
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 697 bits (1799), Expect = 0.0
Identities = 447/1416 (31%), Positives = 736/1416 (51%), Gaps = 173/1416 (12%)
Query: 44 NPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVAR 103
NP A LS T+SW +++KGY++ LT++ + + + T +F E+ +
Sbjct: 193 NPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQK 252
Query: 104 VG------PEKAS--------------------------------------------LSH 113
EK+S L
Sbjct: 253 ARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMK 312
Query: 114 VVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATE 173
++K +L + ++ I + P +L I ++R + +W+G I LF
Sbjct: 313 ALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDT-YLWIGYLCAILLFTAA 371
Query: 174 FTKVFFWALAWAINYRTAIRLKVALSTLVFENLVSFKTLTH--ISVGEVLNILSSDSYSL 231
+ F + + ++ ++++ A+ V++ ++ L +VGE +N++S D+ L
Sbjct: 372 LIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKL 431
Query: 232 FEAALFCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSA 291
+ F + + + +V + + LGP+ L G+ V V+ IP+ ++ + +
Sbjct: 432 MDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKN 491
Query: 292 ILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAP 351
+ DKR++ MNE L+ I+++K +AWE SF + +Q++R++E K L +Q +
Sbjct: 492 MKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQ 551
Query: 352 IVSTIAIVLTLSCHILLRRK--LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLR 409
+ + V+T S ++L+ L A AF+ I +FN+++F +++LP I +M +A+VS
Sbjct: 552 LTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTE 611
Query: 410 RMKKILI-DKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQR 468
R++K L D S I + D + + A+ TWEH++
Sbjct: 612 RLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDS--------------------- 650
Query: 469 SEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLG 528
++ + ++ + G+++ + G VGSGKSSL++A+LG
Sbjct: 651 ------------------------EATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLG 686
Query: 529 QMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNL 588
+M+ G + + GT AYV QQ+WI +G +++NILFG +++ +RYQ + C L DL L
Sbjct: 687 EMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEML 746
Query: 589 PYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKK 648
P GDL EIGE+G+NLSGGQ+QRISLARA Y + +YLLDDPLSAVDAHVGKH+F + +
Sbjct: 747 PGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGP 806
Query: 649 T--LRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQ 706
L+GKT +LVTH + FL DE+++L +G I EKG++ L+ ++G +AK + L+
Sbjct: 807 NGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTF--LR 864
Query: 707 FKDPEHLYNAAMVEAFKE---------SPAEREEDAGIIVLAPGNE---------KDEGK 748
PE A + + +E S E EDA I + N + G+
Sbjct: 865 HTGPEE--EATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGR 922
Query: 749 ESETGSEFVDTK-----------VPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLF 797
++ + T+ V +LI+ E + G V + Y Y++A G L S+F
Sbjct: 923 HLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIG--LFSIF 980
Query: 798 TVFLFLLMIGSAAF--SNWWLGLWLDKGS--RMTCGPQGNRTMCEVGAVLADIGQHVYQW 853
+ L +M S AF SN WL W T P R M VG VY
Sbjct: 981 FIILAFVM-NSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDM-RVG---------VYGA 1029
Query: 854 VYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFS 913
+ A +F+ + F F AS+ LH + + IL++PM FFDTTPTGR++NRF+
Sbjct: 1030 LGLAQGIFVFIAHFWSAFGFVH----ASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFA 1085
Query: 914 KDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGV 973
D+ +D LP +++ F ++ LV++ P ++V L + + + +
Sbjct: 1086 GDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTS 1145
Query: 974 QELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYHLLYFN----CAL------R 1023
++L+++++V+RSP ++H + ++ GL +I A+ ++ + ++ + + C R
Sbjct: 1146 RQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNR 1205
Query: 1024 WFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAK 1083
W A+R++++ N+ F AL++ + ++S + G LS + ++ L VR +E +
Sbjct: 1206 WLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETN 1265
Query: 1084 FTSVELLREY--ISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLN 1141
+VE + EY + P T P DWPS+G+I F +YQ+RYR LVL +
Sbjct: 1266 IVAVERITEYTKVENEAPWVTDKRP----PPDWPSKGKIQFNNYQVRYRPELDLVLRGIT 1321
Query: 1142 LNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIP 1201
+I S + +G+VGRTG+GKSSL LFR++E A G I ID VDI + L DLR KLT+IP
Sbjct: 1322 CDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIP 1381
Query: 1202 QDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGE 1261
QDP+LF G++R NLDPF +++DE +W+ LE ++ + L L EVTE G N S+G+
Sbjct: 1382 QDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQ 1441
Query: 1262 RQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNC 1321
RQLLC+ RALLR SKI++LDEATA++D +TD L+Q TI++ F CTV+TIAHRL+T+++
Sbjct: 1442 RQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDS 1501
Query: 1322 DHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEV 1357
D V+V++NGK+IE PE L + P + M A +
Sbjct: 1502 DKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 668 bits (1723), Expect = 0.0
Identities = 442/1381 (32%), Positives = 702/1381 (50%), Gaps = 164/1381 (11%)
Query: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLW----- 97
P P AG LS F W T + + GYR L L L D S ++ W
Sbjct: 206 PYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEK 265
Query: 98 -----------------DEEV---ARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMA 137
++EV AR P K S + + L+ ++ +++
Sbjct: 266 QTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLS 325
Query: 138 AIGPVILIHQILQQTERTSGKVWVG------IGLCIALFATEFTKVFFWALAWAINYRTA 191
I P +L +++ W G + LC + + + + + +RT
Sbjct: 326 FINPQLL-SILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTG 384
Query: 192 IRLKVALSTLVFENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFC 251
I + LV N V + +VGE++N++S D+ + A F L + P+ ++
Sbjct: 385 IMGVIYRKALVITNSVKRAS----TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILA 440
Query: 252 AAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRL 311
+ + LGP+ L G++ V+ IP+ +A AF+ + + D R++ M+E L I++
Sbjct: 441 IYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKV 500
Query: 312 IKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNS---ALAPIVSTIAIVLTLSCHILL 368
+K+YAWE SF ++ IR+ E +LL A ++ + + +P + T+ I L + ++
Sbjct: 501 LKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTL-ITLWVYVYVDP 559
Query: 369 RRKLTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKS--PPSYITQ 426
L A AF +++FN+++ + +LP I + +A+VSL+R+++ L + P S +
Sbjct: 560 NNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERK 619
Query: 427 PEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPE 486
P + + + T TW + PP
Sbjct: 620 TISPGYAITIHSGTFTWAQDL-----------------------------PPT------- 643
Query: 487 EQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYV 546
LHS+ V KG ++ + G VG GKSSL++ALLG+M+ +G V + G++AYV
Sbjct: 644 ---------LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYV 694
Query: 547 SQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGG 606
QQAWI + ++EN+LFG+ + +RYQ T+ C L DL LP GD TEIGE+G+NLSGG
Sbjct: 695 PQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGG 754
Query: 607 QRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECI--KKTLRGKTVVLVTHQLQF 664
QRQR+SLARAVYSD ++LLDDPLSAVD+HV KH+F+ I + L GKT VLVTH + F
Sbjct: 755 QRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISF 814
Query: 665 LESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYN--------- 715
L D +I+L DG++ E G + L++ G +A + N +D HL +
Sbjct: 815 LPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYA--PDEDQGHLEDSWTALEGAE 872
Query: 716 ---AAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQL------ 766
A ++E + + ++ + + + + E VP L
Sbjct: 873 DKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKV 932
Query: 767 -----------IQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFS--- 812
Q E GTV + Y KA G T+ + LL +G +A +
Sbjct: 933 QVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVG----LCTTLAICLLYVGQSAAAIGA 988
Query: 813 NWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFV 872
N WL W + + N T +G V A +G + +V + + G +
Sbjct: 989 NVWLSAWTNDAM---ADSRQNNTSLRLG-VYAALG------ILQGFLVMLAAMAMAAGGI 1038
Query: 873 FTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQ 932
A+ LH + ++SP SFFDTTP+GR++N FSKD+ +D L L
Sbjct: 1039 ------QAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLN 1092
Query: 933 QFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHIT 992
FF + LV++ A P +V+ LAV + ++ R + ++LK++E+VSRSP ++H +
Sbjct: 1093 SFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFS 1152
Query: 993 SSMQGLGIIHAYGK---------------KESCITYHLLYFNCALRWFALRMDVLMNILT 1037
++ G +I AY + + SC Y + + RW ++ ++ + N +
Sbjct: 1153 ETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYII-----SNRWLSIGVEFVGNCVV 1207
Query: 1038 FTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTC 1097
AL + SS++ GLS+SY +Q++ L +R ++ ++ +VE ++EY T
Sbjct: 1208 LFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKT- 1266
Query: 1098 VPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTG 1157
E ++ P+ WP RGE+ FR+Y +RYR LVL L+L++ G+ VGIVGRTG
Sbjct: 1267 ETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTG 1326
Query: 1158 SGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDP 1217
+GKSS+ + LFR++E A G I ID +++ + L DLR++LT+IPQDP+LF GT+R NLDP
Sbjct: 1327 AGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDP 1386
Query: 1218 FESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKI 1277
F S+++E +W LE + + + P L + +E GEN SVG+RQL+C+ARALLR S+I
Sbjct: 1387 FGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRI 1446
Query: 1278 ILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDK 1337
++LDEATA++D +TD L+Q TI+ F CTVLTIAHRLNT+++ VLV++ G V EFD
Sbjct: 1447 LVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDS 1506
Query: 1338 P 1338
P
Sbjct: 1507 P 1507
Score = 83.2 bits (204), Expect = 2e-15
Identities = 144/642 (22%), Positives = 247/642 (38%), Gaps = 97/642 (15%)
Query: 88 TNAKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCII---MAAIGPVIL 144
T AK L EE A +G + S V W + + L +A L + AAIG +
Sbjct: 935 TEAKADGALTQEEKAAIGTVELS---VFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVW 991
Query: 145 IHQILQQTERTS--GKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIR-LKVALSTL 201
+ S + +G+ AL + V A+A A A R L AL
Sbjct: 992 LSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHN 1051
Query: 202 VFENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFF--IL 259
+ SF T G +LN S D Y + E P + +L F A + I+
Sbjct: 1052 KIRSPQSFFDTT--PSGRILNCFSKDIYVVDEVLA----PVILMLLNSFFNAISTLVVIM 1105
Query: 260 GPTALIGISVY---VIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYA 316
T L + + V++ VQ F A + +R + +E +T +I+ Y
Sbjct: 1106 ASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYN 1165
Query: 317 WEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVS----TIAIVLTLSCHILLRRKL 372
R R+ +++ + S I+S +I + +C +L
Sbjct: 1166 ------------RSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFA--- 1210
Query: 373 TAPVAFSVIAMFNVMKFSIAI-LPFSIKAMAEANVSLRRMKK-----ILIDKSPPSYITQ 426
F+VI ++ + + + +S++ N +R M + +++ T+
Sbjct: 1211 ---ALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTE 1267
Query: 427 PEDPDTVLLLANATLTWEHEASR--KSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATG 484
E P W E SR + P + + + R+ YS R P
Sbjct: 1268 TEAP------------WVVEGSRPPEGWPPRGEVEFRN---------YSVRYRPG----- 1301
Query: 485 PEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT-- 542
L VL +S V G+ +GI G G+GKSS+ L ++ KG + ++G
Sbjct: 1302 -------LDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNV 1354
Query: 543 -----------LAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYG 591
L + Q +F G +R N+ Y + + + L +S+ P G
Sbjct: 1355 ADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAG 1414
Query: 592 DLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLR 651
+ E G NLS GQRQ + LARA+ ++ +LD+ +A+D ++ + I+
Sbjct: 1415 LDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLET-DNLIQATIRTQFD 1473
Query: 652 GKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERG 693
TV+ + H+L + V++L+ G + E + L+ RG
Sbjct: 1474 TCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARG 1515
Score = 74.3 bits (181), Expect = 7e-13
Identities = 59/237 (24%), Positives = 109/237 (45%), Gaps = 17/237 (7%)
Query: 1120 ITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIF 1179
IT + + P L SL++ + G V +VG G GKSSL AL +E G +
Sbjct: 627 ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH 686
Query: 1180 IDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTI 1239
++ + +PQ + T++ N+ ++ + Q LE + +
Sbjct: 687 -------------MKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADL 733
Query: 1240 MKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTI 1299
LP Q E+ E G N S G+RQ + +ARA+ ++ I LLD+ +++DS + + +
Sbjct: 734 EMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHV 793
Query: 1300 ---KDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLL 1353
+ G T + + H ++ + D ++V+ +G+V E L ++ + +FA L
Sbjct: 794 IGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQR-NGSFANFL 849
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 622 bits (1604), Expect = e-178
Identities = 409/1293 (31%), Positives = 652/1293 (50%), Gaps = 143/1293 (11%)
Query: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVA 102
P P A LS TF W+T ++V+GYRQ L L L+ D+S+ W +E A
Sbjct: 207 PCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECA 266
Query: 103 RV-----------------------------------GPEKA---SLSHVVWKFQRTRVL 124
+ P+K SL V++K L
Sbjct: 267 KTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFL 326
Query: 125 MDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAW 184
M + +M GP IL +++ T W G + LF T + +
Sbjct: 327 MSFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYF 385
Query: 185 AINYRTAIRLKVALSTLVFEN--LVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPA 242
I + + +R+K A+ V+ +++ +VGE++N++S D+ + A + +
Sbjct: 386 HICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIW 445
Query: 243 TIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTM 302
+ P+ ++ + LGP+ L G++V V+ +PV MA ++ + + D R++ M
Sbjct: 446 SAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLM 505
Query: 303 NEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTL 362
NE L I+++K+YAWE +F + + IR+ E K+L+K+ ++ + + + + T
Sbjct: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTF 565
Query: 363 SCHILLRRK--LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKS- 419
+ ++ + L A AF +A+FN+++F + ILP I ++ +A+VSL+R++ L +
Sbjct: 566 AVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEEL 625
Query: 420 -PPSYITQPEDPD---TVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSER 475
P S +P + + NAT TW +
Sbjct: 626 EPDSIERRPVKDGGGTNSITVRNATFTW-----------------------------ARS 656
Query: 476 SPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKG 535
PP L+ I+F + +G ++ + G VG GKSSLL+ALL +M +G
Sbjct: 657 DPPT----------------LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG 700
Query: 536 VVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTE 595
VA+ G++AYV QQAWI + ++RENILFG + + Y+ ++ C L DL LP GD TE
Sbjct: 701 HVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTE 760
Query: 596 IGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECI--KKTLRGK 653
IGE+G+NLSGGQ+QR+SLARAVYS+ +YL DDPLSAVDAHVGKH+FE I K L+ K
Sbjct: 761 IGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNK 820
Query: 654 TVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGL-QFKDPEH 712
T +LVTH + +L D +I++ G+I E G+++EL+ G +A+ + Q +D E
Sbjct: 821 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEE 880
Query: 713 LYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVD-------------- 758
+ KE+ ++ + G++V ++ + + S + S D
Sbjct: 881 NGVTGVSGPGKEA---KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKA 937
Query: 759 --TKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWL 816
K +L++ + Q G V Y Y+KA G +S ++FLF+ SA SN+WL
Sbjct: 938 EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAI-GLFISFLSIFLFMCNHVSALASNYWL 996
Query: 817 GLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKT 876
LW D P N T L+ G + VF V+ G
Sbjct: 997 SLWTD-------DPIVNGTQEHTKVRLSVYGA---LGISQGIAVFGYSMAVSIG------ 1040
Query: 877 TLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFM 936
++AS LH + IL+SPMSFF+ TP+G L+NRFSK++D +D +P + F+ F
Sbjct: 1041 GILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFN 1100
Query: 937 VVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQ 996
V+ +++ P +++ L + +F + R + ++LK++E+VSRSP ++H ++
Sbjct: 1101 VIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLL 1160
Query: 997 GLGIIHAYGKKESCITYHLLYFN----------CALRWFALRMDVLMNILTFTVALLVTL 1046
G+ +I A+ ++E I L + A RW A+R++ + N + AL +
Sbjct: 1161 GVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1220
Query: 1047 SFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLK 1106
S S+S GLS+SY +Q++ L VR +E + +VE L+EY T E ++
Sbjct: 1221 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQ 1279
Query: 1107 VGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMA 1166
P WP G + FR+Y +RYR++ VL +N+ I G+ VGIVGRTG+GKSSL +
Sbjct: 1280 ETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLG 1339
Query: 1167 LFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEML 1226
LFR+ E A G I ID ++I + L DLR K+T+IPQDPVLF G++R NLDPF ++DE +
Sbjct: 1340 LFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEV 1399
Query: 1227 WQVLERTFMRDTIMKLPEKLQAEVTENGENFSV 1259
W LE ++D + LP+KL E E GEN V
Sbjct: 1400 WTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
Score = 79.3 bits (194), Expect = 2e-14
Identities = 64/246 (26%), Positives = 114/246 (46%), Gaps = 19/246 (7%)
Query: 1112 KDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLV 1171
KD IT R+ + + P L+ + +I G V +VG+ G GKSSL AL +
Sbjct: 636 KDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEM 695
Query: 1172 EPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQ-VL 1230
+ G + I + + +PQ + ++R N+ F +E ++ V+
Sbjct: 696 DKVEGHVAI-------------KGSVAYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVI 741
Query: 1231 ERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSK 1290
+ + + LP + E+ E G N S G++Q + +ARA+ N+ I L D+ +++D+
Sbjct: 742 QACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAH 801
Query: 1291 TDT-LVQNTI--KDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDS 1347
+ +N I K K T + + H ++ + D ++VM GK+ E + L + D
Sbjct: 802 VGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DG 860
Query: 1348 AFAMLL 1353
AFA L
Sbjct: 861 AFAEFL 866
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 615 bits (1585), Expect = e-175
Identities = 421/1385 (30%), Positives = 678/1385 (48%), Gaps = 202/1385 (14%)
Query: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVA 102
P P A LS TF W+T ++V+GYRQ L L L+ D+S+ W +E A
Sbjct: 207 PCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECA 266
Query: 103 RV-----------------------------------GPEKA---SLSHVVWKFQRTRVL 124
+ P+K SL V++K L
Sbjct: 267 KTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFL 326
Query: 125 MDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAW 184
M + +M GP IL +++ T W G + LF T + +
Sbjct: 327 MSFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYF 385
Query: 185 AINYRTAIRLKVALSTLVFEN--LVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPA 242
I + + +R+K A+ V+ +++ +VGE++N++S D+ + A + +
Sbjct: 386 HICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIW 445
Query: 243 TIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTM 302
+ P+ ++ + LGP+ L G++V V+ +PV MA ++ + + D R++ M
Sbjct: 446 SAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLM 505
Query: 303 NEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTL 362
NE L I+++K+YAWE +F + + IR+ E K+L+K+ ++ + + + + T
Sbjct: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTF 565
Query: 363 SCHILLRRK--LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILI--DK 418
+ ++ + L A AF +A+FN+++F + ILP I ++ +A+VSL+R++ L +
Sbjct: 566 AVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEEL 625
Query: 419 SPPSYITQPEDP---DTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSER 475
P S +P + + NAT TW +
Sbjct: 626 EPDSIERRPVKDGGGTNSITVRNATFTW-----------------------------ARS 656
Query: 476 SPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKG 535
PP L+ I+F + +G ++ + G VG GKSSLL+ALL +M +G
Sbjct: 657 DPP----------------TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG 700
Query: 536 VVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTE 595
VA+ G V + G QK +L
Sbjct: 701 HVAIKG----------------------------------VNLSGGQKQRVSL------- 719
Query: 596 IGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECI--KKTLRGK 653
ARAVYS+ +YL DDPLSAVDAHVGKH+FE I K L+ K
Sbjct: 720 ------------------ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNK 761
Query: 654 TVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGL-QFKDPEH 712
T +LVTH + +L D +I++ G+I E G+++EL+ G +A+ + Q +D E
Sbjct: 762 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEE 821
Query: 713 LYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVD-------------- 758
+ KE+ ++ + G++V ++ + + S + S D
Sbjct: 822 NGVTGVSGPGKEA---KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKA 878
Query: 759 --TKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWL 816
K +L++ + Q G V Y Y+KA G +S ++FLF+ SA SN+WL
Sbjct: 879 EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAI-GLFISFLSIFLFMCNHVSALASNYWL 937
Query: 817 GLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKT 876
LW D P N T L+ G + VF V+ G
Sbjct: 938 SLWTD-------DPIVNGTQEHTKVRLSVYGA---LGISQGIAVFGYSMAVSIG------ 981
Query: 877 TLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFM 936
++AS LH + IL+SPMSFF+ TP+G L+NRFSK++D +D +P + F+ F
Sbjct: 982 GILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFN 1041
Query: 937 VVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQ 996
V+ +++ P +++ L + +F + R + ++LK++E+VSRSP ++H ++
Sbjct: 1042 VIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLL 1101
Query: 997 GLGIIHAYGKKESCITYHLLYFN----------CALRWFALRMDVLMNILTFTVALLVTL 1046
G+ +I A+ ++E I L + A RW A+R++ + N + AL +
Sbjct: 1102 GVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1161
Query: 1047 SFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLK 1106
S S+S GLS+SY +Q++ L VR +E + +VE L+EY T E ++
Sbjct: 1162 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQ 1220
Query: 1107 VGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMA 1166
P WP G + FR+Y +RYR++ VL +N+ I G+ VGIVGRTG+GKSSL +
Sbjct: 1221 ETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLG 1280
Query: 1167 LFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEML 1226
LFR+ E A G I ID ++I + L DLR K+T+IPQDPVLF G++R NLDPF ++DE +
Sbjct: 1281 LFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEV 1340
Query: 1227 WQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATAS 1286
W LE ++D + LP+KL E E GEN SVG+RQL+C+ARALLR +KI++LDEATA+
Sbjct: 1341 WTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAA 1400
Query: 1287 MDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPD 1346
+D +TD L+Q+TI+ F+ CTVLTIAHRLNT+++ V+V++ G++ E+ P L ++
Sbjct: 1401 VDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1460
Query: 1347 SAFAM 1351
++M
Sbjct: 1461 LFYSM 1465
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 609 bits (1570), Expect = e-174
Identities = 414/1383 (29%), Positives = 676/1383 (48%), Gaps = 195/1383 (14%)
Query: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVA 102
P P A LS TF W+T ++V+GYRQ L L L+ D+S+ W +E A
Sbjct: 207 PCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECA 266
Query: 103 RV-----------------------------------GPEKA---SLSHVVWKFQRTRVL 124
+ P+K SL V++K L
Sbjct: 267 KTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFL 326
Query: 125 MDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAW 184
M + +M GP IL +++ T W G + LF T + +
Sbjct: 327 MSFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYF 385
Query: 185 AINYRTAIRLKVALSTLVFEN--LVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPA 242
I + + +R+K A+ V+ +++ +VGE++N++S D+ + A + +
Sbjct: 386 HICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIW 445
Query: 243 TIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTM 302
+ P+ ++ + LGP+ L G++V V+ +PV MA ++ + + D R++ M
Sbjct: 446 SAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLM 505
Query: 303 NEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTL 362
NE L I+++K+YAWE +F + + IR+ E K+L+K+ ++ + + + + T
Sbjct: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTF 565
Query: 363 SCHILLRRK--LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKS- 419
+ ++ + L A AF +A+FN+++F + ILP I ++ +A+VSL+R++ L +
Sbjct: 566 AVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEEL 625
Query: 420 -PPSYITQPEDPD---TVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSER 475
P S +P + + NAT TW +
Sbjct: 626 EPDSIERRPVKDGGGTNSITVRNATFTW-----------------------------ARS 656
Query: 476 SPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKG 535
PP L+ I+F + +G ++ + G VG GKSSLL+ALL +M +G
Sbjct: 657 DPPT----------------LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG 700
Query: 536 VVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTE 595
VA+ G++AYV QQAWI + ++RENILFG + + Y+ ++ C L DL LP
Sbjct: 701 HVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILP------ 754
Query: 596 IGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTV 655
G R I KT
Sbjct: 755 ---------SGDRTEIG---------------------------------------EKTR 766
Query: 656 VLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGL-QFKDPEHLY 714
+LVTH + +L D +I++ G+I E G+++EL+ G +A+ + Q +D E
Sbjct: 767 ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENG 826
Query: 715 NAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDT--------------- 759
+ KE+ ++ + G++V ++ + + S + S D
Sbjct: 827 VTGVSGPGKEA---KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 883
Query: 760 -KVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGL 818
K +L++ + Q G V Y Y+KA G ++ S ++FLF+ SA SN+WL L
Sbjct: 884 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFI-SFLSIFLFMCNHVSALASNYWLSL 942
Query: 819 WLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTL 878
W D P N T L+ G + VF V+ G +
Sbjct: 943 WTDD-------PIVNGTQEHTKVRLSVYGA---LGISQGIAVFGYSMAVSIGGI------ 986
Query: 879 MASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVV 938
+AS LH + IL+SPMSFF+ TP+G L+NRFSK++D +D +P + F+ F V+
Sbjct: 987 LASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVI 1046
Query: 939 FILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGL 998
+++ P +++ L + +F + R + ++LK++E+VSRSP ++H ++ G+
Sbjct: 1047 GACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGV 1106
Query: 999 GIIHAYGKKESCITYHLLYFN----------CALRWFALRMDVLMNILTFTVALLVTLSF 1048
+I A+ ++E I L + A RW A+R++ + N + AL +S
Sbjct: 1107 SVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1166
Query: 1049 SSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVG 1108
S+S GLS+SY +Q++ L VR +E + +VE L+EY T E ++
Sbjct: 1167 HSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQET 1225
Query: 1109 TCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALF 1168
P WP G + FR+Y +RYR++ VL +N+ I G+ VGIVGRTG+GKSSL + LF
Sbjct: 1226 APPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLF 1285
Query: 1169 RLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQ 1228
R+ E A G I ID ++I + L DLR K+T+IPQDPVLF G++R NLDPF ++DE +W
Sbjct: 1286 RINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWT 1345
Query: 1229 VLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMD 1288
LE ++D + LP+KL E E GEN SVG+RQL+C+ARALLR +KI++LDEATA++D
Sbjct: 1346 SLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVD 1405
Query: 1289 SKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSA 1348
+TD L+Q+TI+ F+ CTVLTIAHRLNT+++ V+V++ G++ E+ P L ++
Sbjct: 1406 LETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1465
Query: 1349 FAM 1351
++M
Sbjct: 1466 YSM 1468
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 595 bits (1535), Expect = e-170
Identities = 407/1389 (29%), Positives = 687/1389 (49%), Gaps = 115/1389 (8%)
Query: 51 LLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVAR--VGPEK 108
LLS T+ W+ + +++ + + + L + TN +R +D +V + G +
Sbjct: 224 LLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQG 283
Query: 109 A-----SLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILI---------HQILQQTER 154
A +LSH + R+++ IL ++ GP+ + + + Q +
Sbjct: 284 ARAIWQALSHAFGR----RLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQ 339
Query: 155 TSGKVWVGIG--------LCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENL 206
G +V L + LF + F ++ + T I L+ A+ T ++ +
Sbjct: 340 FLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKI 399
Query: 207 VSFKT----LTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPT 262
+ T + ++ G++ N+++ D+ L CP +P+ ++ ++ILG +
Sbjct: 400 MHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVS 459
Query: 263 ALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFT 322
ALIG +V ++ PVQ F+A S +RS + +++R++ NE L I+L+K+YAWE F
Sbjct: 460 ALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFR 519
Query: 323 NTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRK--LTAPVAFSV 380
++ RR+E L S + + + A+++T H+ ++ + VAF+
Sbjct: 520 TRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFAS 579
Query: 381 IAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANAT 440
+++F+++ + +L +++ +A VS++++ + L P +P
Sbjct: 580 LSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEP---------- 629
Query: 441 LTWEHEASR-KSTPKKLQNQKRHLCKKQRSEAYSERS--PPAKGAT---------GPEEQ 488
T + AS+ ++ P ++ N+KR + R +S P A G G
Sbjct: 630 -TPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTW 688
Query: 489 SDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVV----------- 537
+ L +I+ + +G++ I G VG GKSSLL A LG+MQ G V
Sbjct: 689 TPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIG 748
Query: 538 ---------------AVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQ 582
G +AY SQ+ W+ + V ENI+F ++ QRY+ + C LQ
Sbjct: 749 EDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQ 808
Query: 583 KDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVF 642
D+ LP+GD T+IGERG+NLSGGQRQRIS+ARA+Y + LDDP SA+D H+ H+
Sbjct: 809 PDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLM 868
Query: 643 EECIKKTLRG--KTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIH 700
+ I + LR +TVVLVTH+LQ+L D +I ++DG I +GT K+ +L
Sbjct: 869 QAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE---CQLFE 925
Query: 701 NLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTK 760
+ + L + + L + E P + A + G +DE +E E +E
Sbjct: 926 HWKTLMNRQDQELEKETVTERKATEPPQGLSRA--MSSRDGLLQDEEEEEEEAAES---- 979
Query: 761 VPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWL 820
E + + Q + W+ Y+ ++G LLSL VF LL ++WL W
Sbjct: 980 -EEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLL-VFSQLLKHMVLVAIDYWLAKWT 1037
Query: 821 DKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMA 880
D S +T P L Q VY V+T +V + T L
Sbjct: 1038 D--SALTLTPAARNCSLSQECTL---DQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKV 1092
Query: 881 SSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFI 940
+ LH ++ ++I+ +PM FF+TTP G ++NRFS D + +D +P E + + V
Sbjct: 1093 AKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSA 1152
Query: 941 LVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGI 1000
L +++ V P L+ + LA+ + + + F ++L+++++ ++ P +H +++GL
Sbjct: 1153 LAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTT 1212
Query: 1001 IHAYGKK----ESCITYH------LLYFNCALRWFALRMDVLMNILTFTVALLVTLSFS- 1049
I A+ + + + Y L+ A RW +RM+ + +A + ++S S
Sbjct: 1213 IRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYI-GACVVLIAAVTSISNSL 1271
Query: 1050 --SISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKV 1107
+S GL L+Y + +S L VR + + + +V+ + + T L
Sbjct: 1272 HRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAP 1331
Query: 1108 GTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMAL 1167
PK+WP +G+I ++ +RY + VL +N I GQ +GI GRTGSGKSS +A
Sbjct: 1332 SLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAF 1391
Query: 1168 FRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLW 1227
FR+V+ G I ID +DI L L LR++L++I QDPVLF GT+R+NLDP +D LW
Sbjct: 1392 FRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLW 1451
Query: 1228 QVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASM 1287
+ LE ++ + LP L A +TE GENFS G+RQL C+ARA +R + I ++DEATAS+
Sbjct: 1452 EALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASI 1511
Query: 1288 DSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDS 1347
D T+ ++Q + AF TV+TIAHR++T+L+ D V+V++ G ++EFDKPE L + DS
Sbjct: 1512 DMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDS 1571
Query: 1348 AFAMLLAAE 1356
FA + A+
Sbjct: 1572 VFASFVRAD 1580
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 584 bits (1506), Expect = e-166
Identities = 399/1382 (28%), Positives = 689/1382 (49%), Gaps = 129/1382 (9%)
Query: 51 LLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVG--PEK 108
LLS AT+ W+ +++ +++ + + + L + TN + ++E+ +V P +
Sbjct: 222 LLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNR 281
Query: 109 A-SLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCI 167
S+ +++ +L+ L ++ GP + I I+Q+ T G+
Sbjct: 282 TPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGP-LCISGIVQRVNETQNGTNNTTGISE 340
Query: 168 ALFATEFTK-------VFFWAL---------AWAINYRTAIRLKVALSTLVFENLVSFKT 211
L + EF + + F AL ++ + T I L+ AL +++ ++ T
Sbjct: 341 TLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLST 400
Query: 212 ----LTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGI 267
+ +++G++ N+++ ++ L CP +P+ ++ + +LG +AL+G
Sbjct: 401 SNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGA 460
Query: 268 SVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQD 327
+V V+ P+Q F+A + ++S + + +R++ NE L I+L+K+YAWE F ++++
Sbjct: 461 AVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEE 520
Query: 328 IRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPV-AFSVIAMFNV 386
R +E L+ S + + + A++ T H P AF+ +++F++
Sbjct: 521 TRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHI 580
Query: 387 MKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWE-- 444
+ + +L ++ +A +S++++ + L+ E D ++L +E
Sbjct: 581 LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSD---------EIGDDSWRTGESSLPFESC 631
Query: 445 --HEASRKSTPKKLQNQKRHLCKKQRSEAY---SERSPPAKGATGPEEQSDSLKSVLHSI 499
H + T + Q + HL ++S +E A T S + L +I
Sbjct: 632 KKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNI 691
Query: 500 SFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG-----------------T 542
+ G++ I G VG GKSSLL A+LG+MQ +G V + +
Sbjct: 692 DIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYS 751
Query: 543 LAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLN 602
+AY +Q+ W+ + V ENI FG ++ QRY+ C LQ D+ LP+GD TEIGERG+N
Sbjct: 752 VAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGIN 811
Query: 603 LSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRG--KTVVLVTH 660
LSGGQRQRI +ARA+Y + + LDDP SA+D H+ H+ +E I K L+ +T+VLVTH
Sbjct: 812 LSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTH 871
Query: 661 QLQFLESCDEVILLEDGEICEKGTHKELME---ERGRYAKLIHNLRGLQF-KDPEHLYNA 716
+LQ+L D +I ++DG + +GT K++ E + K + N + + KD E
Sbjct: 872 KLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTT 931
Query: 717 AMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGT 776
+ + + RE A + ++DE +E E E D + ++T+ P
Sbjct: 932 LERKTLRRAMYSREAKAQM------EDEDEEEEEE---EDEDDNMSTVMRLRTKMP---- 978
Query: 777 VTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQ----- 831
WKT Y+ SGG+ L + +F LL ++WL W + S G
Sbjct: 979 --WKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYY 1035
Query: 832 --GNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVF 889
G +C G L + +W+ L A+ +LH +
Sbjct: 1036 VAGFSILCGAGIFLCLVTSLTVEWM----------------------GLTAAKNLHHNLL 1073
Query: 890 DKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFP 949
+KI+ P+ FFDTTP G ++NRFS D + +D +P E+ + + + + +++ P
Sbjct: 1074 NKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATP 1133
Query: 950 AVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKK-- 1007
L+ + L V F+ + + F ++L+++++ ++ P H + + +GL I A+ +
Sbjct: 1134 VFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETR 1193
Query: 1008 ------ESCITYHL--LYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSK--- 1056
E T ++ L+ + A RW +R D L +++T S +SIS SS
Sbjct: 1194 FKQRMLELTDTNNIAYLFLSAANRWLEVRTDYL------GACIVLTASIASISGSSNSGL 1247
Query: 1057 -GLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWP 1115
GL L Y + ++ L VR + + + +V+ + +++ + P+ WP
Sbjct: 1248 VGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWP 1307
Query: 1116 SRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPAS 1175
GEI D +RY +N VL + I+ GQ VGI GRTGSGKSSL +A FR+V+
Sbjct: 1308 QEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFD 1367
Query: 1176 GTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFM 1235
G I ID +DI L L LR++L++I QDP+LF G++R+NLDP TD+ LW+ LE +
Sbjct: 1368 GKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQL 1427
Query: 1236 RDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLV 1295
++ + LP L A VTE GENFSVG+RQL C+ARA +R S I+++DEATAS+D T+ ++
Sbjct: 1428 KNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENIL 1487
Query: 1296 QNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAA 1355
Q + AF TV+TIAHR++T+L D V+VM+ G ++E+D PE L + + FA + A
Sbjct: 1488 QKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVRA 1547
Query: 1356 EV 1357
++
Sbjct: 1548 DM 1549
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 583 bits (1503), Expect = e-166
Identities = 413/1368 (30%), Positives = 678/1368 (49%), Gaps = 145/1368 (10%)
Query: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLW----- 97
P P A S ATF W++ ++ +GYR+ L L L +SS+ R W
Sbjct: 202 PCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRS 261
Query: 98 ------------------------DEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILC 133
+ + + G + L +W+ + L+ ++ I+
Sbjct: 262 AARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIIS 321
Query: 134 IIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIR 193
+ P +L L+ W G L + +F + + F +R
Sbjct: 322 DVFRFTVPKLL-SLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMR 380
Query: 194 LKVALSTLVFENLVSFKTLTH--ISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFC 251
L+ A++ LV+ +++ + + +VG+V+N++S D L E+ L+ + +V C
Sbjct: 381 LRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVC 440
Query: 252 AAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRL 311
Y + +LGP+AL I+V++ +P+ F++K + + + D R + + L +
Sbjct: 441 FVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKT 500
Query: 312 IKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRK 371
IK + WE +F + + IR +E L +G + S + + + + ++ + H L+
Sbjct: 501 IKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAEN 560
Query: 372 -LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDP 430
+ A AF + + N++ + A LPFSI ++ +A VS R+ L + DP
Sbjct: 561 AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLC--------LEEVDP 612
Query: 431 DTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSD 490
V + +S + K + + A+S+ SPP
Sbjct: 613 GVV----------DSSSSGSAAGKDC------ITIHSATFAWSQESPPC----------- 645
Query: 491 SLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQA 550
LH I+ V +G +L + G VG+GKSSLL+ALLG++ +G V++ G +AYV Q+A
Sbjct: 646 -----LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEA 700
Query: 551 WIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQR 610
W+ + +V EN+ FG++ D + + C LQ D+ + P G T IGE+G+NLSGGQ+QR
Sbjct: 701 WVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQR 760
Query: 611 ISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKK--TLRGKTVVLVTHQLQFLESC 668
+SLARAVY +YLLDDPL+A+DAHVG+HVF + I L+G T +LVTH L L
Sbjct: 761 LSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQA 820
Query: 669 DEVILLEDGEICEKGTHKELMEERGRYAKLIHNLR------------GLQFKDPEHLYNA 716
D +I+L +G I E G+++EL++ +G L+ R G KDP
Sbjct: 821 DWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRG---- 876
Query: 717 AMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQT------E 770
A + RE K ++ T SE T+VP + +
Sbjct: 877 --TSAGRRPELRRERSI----------KSVPEKDRTTSE-AQTEVPLDDPDRAGWPAGKD 923
Query: 771 SPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGP 830
S Q G V + Y++A G L L+ +FLFL ++ +WL LW D +
Sbjct: 924 SIQYGRVKATVHLAYLRAV-GTPLCLYALFLFLCQQVASFCRGYWLSLWADDPA-----V 977
Query: 831 QGNRTMCEV-GAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVF 889
G +T + G + +G ++ ASM +L+ G AS L +
Sbjct: 978 GGQQTQAALRGGIFGLLGCLQAIGLF-ASMAAVLLGGA-----------RASRLLFQRLL 1025
Query: 890 DKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFP 949
+++SP+SFF+ TP G L+NRFSK+ D +DV +P + L F ++ + +++A P
Sbjct: 1026 WDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP 1085
Query: 950 AVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKES 1009
+ + L + + ++ +L+++E+ S S +H+ + QG ++ A+ +
Sbjct: 1086 LATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAP 1145
Query: 1010 CITYHLLYFN----------CALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLS 1059
+ + + A RW A +++L N L F A LS + +S G S
Sbjct: 1146 FVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFS 1205
Query: 1060 LSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKD--WPSR 1117
+S +Q++ LQ VR T+ + SVE +++Y T P+ P ++ TC WP
Sbjct: 1206 VSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWT--PK-EAPWRLPTCAAQPPWPQG 1262
Query: 1118 GEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGT 1177
G+I FRD+ +RYR PL + ++ I +G+ VGIVGRTG+GKSSL L RL E A G
Sbjct: 1263 GQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGG 1322
Query: 1178 IFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRD 1237
I+ID V I + L LR+++++IPQDP+LF G++R NLD + H+DE +W LE ++
Sbjct: 1323 IWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKA 1382
Query: 1238 TIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQN 1297
+ LP +LQ + + GE+ SVG++QLLC+ARALLR ++I++LDEATA++D T+ +Q
Sbjct: 1383 LVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQA 1442
Query: 1298 TIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKP-EVLAEK 1344
+ F CTVL IAHRL +V++C VLVM+ G+V E P ++LA+K
Sbjct: 1443 MLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK 1490
Score = 89.7 bits (221), Expect = 2e-17
Identities = 55/220 (25%), Positives = 114/220 (51%), Gaps = 14/220 (6%)
Query: 492 LKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT--------- 542
L + +SF + G+ +GI G G+GKSSL + LL + +G + ++G
Sbjct: 1278 LPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHT 1337
Query: 543 ----LAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
++ + Q +F G++R N+ +++ + + L+ +++LP + +
Sbjct: 1338 LRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCAD 1397
Query: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
RG +LS GQ+Q + LARA+ Q+ +LD+ +AVD + + + TV+L+
Sbjct: 1398 RGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLI 1456
Query: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
H+L+ + C V++++ G++ E G+ +L+ ++G + +L
Sbjct: 1457 AHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1496
Score = 87.4 bits (215), Expect = 8e-17
Identities = 101/492 (20%), Positives = 203/492 (41%), Gaps = 44/492 (8%)
Query: 882 SSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFIL 941
S++ V+ K+L + G ++N S D+ L + + +L ++VV +
Sbjct: 383 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 442
Query: 942 VILAAVFPAVLLVVAS----LAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQG 997
+ + P+ L +A L + FFI + H +++++ ++ +R +TSS+
Sbjct: 443 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRAR------LTSSILR 496
Query: 998 LGIIHAYGKKESCITYHLLYFNC----ALRWFALRMDVLM---NILTFTVALLVTLSFSS 1050
+ E +L ALR L V + + TF VAL+V +
Sbjct: 497 NSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTL 556
Query: 1051 ISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYIS-------TCVPECTH 1103
++ ++ +++ L + + + F+ L++ +S C+ E
Sbjct: 557 VAENAMNAEKAFVT----LTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDP 612
Query: 1104 PLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSL 1163
+ + + IT + +P L +NL + G + +VG G+GKSSL
Sbjct: 613 GVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSL 672
Query: 1164 GMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTD 1223
AL + G + I+ + +PQ+ + +V N+ +
Sbjct: 673 LSALLGELSKVEGFVSIEGA-------------VAYVPQEAWVQNTSVVENVCFGQELDP 719
Query: 1224 EMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEA 1283
L +VLE ++ + PE + + E G N S G++Q L +ARA+ R + + LLD+
Sbjct: 720 PWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDP 779
Query: 1284 TASMDSKTDTLVQNTI---KDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEV 1340
A++D+ V N + +G T + + H L+ + D ++V+ NG + E +
Sbjct: 780 LAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQE 839
Query: 1341 LAEKPDSAFAML 1352
L ++ + +L
Sbjct: 840 LLQRKGALVCLL 851
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 582 bits (1501), Expect = e-166
Identities = 412/1368 (30%), Positives = 679/1368 (49%), Gaps = 145/1368 (10%)
Query: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLW----- 97
P P A S ATF W++ ++ +GYR+ L L L +SS+ R W
Sbjct: 11 PCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRS 70
Query: 98 ------------------------DEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILC 133
+ + + G + L +W+ + L+ ++ I+
Sbjct: 71 AARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIIS 130
Query: 134 IIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIR 193
+ P +L L+ W G L + +F + + F +R
Sbjct: 131 DVFRFTVPKLL-SLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMR 189
Query: 194 LKVALSTLVFENLVSFKTLTH--ISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFC 251
L+ A++ LV+ +++ + + +VG+V+N++S D L E+ L+ + +V C
Sbjct: 190 LRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVC 249
Query: 252 AAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRL 311
Y + +LGP+AL I+V++ +P+ F++K + + + D R + + L +
Sbjct: 250 FVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKT 309
Query: 312 IKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRK 371
IK + WE +F + + IR +E L +G + S + + + + ++ + H L+
Sbjct: 310 IKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAEN 369
Query: 372 -LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDP 430
+ A AF + + N++ + A LPFSI ++ +A VS R+ L + DP
Sbjct: 370 AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLC--------LEEVDP 421
Query: 431 DTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSD 490
V + +S + K + + + A+S+ SPP
Sbjct: 422 GAV----------DSSSSGSAAGKDC------ITIQSATFAWSQESPPC----------- 454
Query: 491 SLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQA 550
LH I+ V +G +L + G VG+GKSSLL+ALLG++ +G V++ G +AYV Q+A
Sbjct: 455 -----LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEA 509
Query: 551 WIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQR 610
W+ + +V EN+ FG++ D + + C LQ D+ + P G T IGE+G+NLSGGQ+QR
Sbjct: 510 WVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQR 569
Query: 611 ISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKK--TLRGKTVVLVTHQLQFLESC 668
+SLARAVY +YLLDDPL+A+DAHVG+HVF + I L+G T +LVTH L L
Sbjct: 570 LSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQA 629
Query: 669 DEVILLEDGEICEKGTHKELMEERGRYAKLIHNLR------------GLQFKDPEHLYNA 716
D +I+L +G I E G+++EL++ +G L+ R G KDP
Sbjct: 630 DWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRG---- 685
Query: 717 AMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQT------E 770
A + RE K ++ T SE T+VP + +
Sbjct: 686 --TSAGRRPELRRERSI----------KSVPEKDRTTSE-AQTEVPLDDPDRAGWPAGKD 732
Query: 771 SPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGP 830
S Q G V + Y++A G L L+ +FLFL ++ +WL LW D +
Sbjct: 733 SIQYGRVKATVHLAYLRAV-GTPLCLYALFLFLCQQVASFCRGYWLSLWADDPA-----V 786
Query: 831 QGNRTMCEV-GAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVF 889
G +T + G + +G ++ ASM +L+ G AS L +
Sbjct: 787 GGQQTQAALRGGIFGLLGCLQAIGLF-ASMAAVLLGGA-----------RASRLLFQRLL 834
Query: 890 DKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFP 949
+++SP+SFF+ TP G L+NRFSK+ D +DV +P + L F ++ + +++A P
Sbjct: 835 WDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP 894
Query: 950 AVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKES 1009
+ + L + + ++ +L+++E+ S S +H+ + QG ++ A+ +
Sbjct: 895 LATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAP 954
Query: 1010 CITYHLLYFN----------CALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLS 1059
+ + + A RW A +++L N L F A LS + +S G S
Sbjct: 955 FVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFS 1014
Query: 1060 LSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKD--WPSR 1117
+S +Q++ LQ VR T+ + SVE +++Y T P+ P ++ TC WP
Sbjct: 1015 VSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWT--PK-EAPWRLPTCAAQPPWPQG 1071
Query: 1118 GEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGT 1177
G+I F+D+ +RYR PL + ++ I +G+ VGIVGRTG+GKSSL L RL E A G
Sbjct: 1072 GQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGG 1131
Query: 1178 IFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRD 1237
I+ID V I + L LR+++++IPQDP+LF G++R NLD + H+DE +W LE ++
Sbjct: 1132 IWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKA 1191
Query: 1238 TIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQN 1297
+ LP +LQ + + GE+ SVG++QLLC+ARALLR ++I++LDEATA++D T+ +Q
Sbjct: 1192 LVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQA 1251
Query: 1298 TIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKP-EVLAEK 1344
+ F CTVL IAHRL +V++C VLVM+ G+V E P ++LA+K
Sbjct: 1252 MLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK 1299
Score = 89.7 bits (221), Expect = 2e-17
Identities = 55/220 (25%), Positives = 114/220 (51%), Gaps = 14/220 (6%)
Query: 492 LKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT--------- 542
L + +SF + G+ +GI G G+GKSSL + LL + +G + ++G
Sbjct: 1087 LPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHT 1146
Query: 543 ----LAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
++ + Q +F G++R N+ +++ + + L+ +++LP + +
Sbjct: 1147 LRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCAD 1206
Query: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
RG +LS GQ+Q + LARA+ Q+ +LD+ +AVD + + + TV+L+
Sbjct: 1207 RGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLI 1265
Query: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
H+L+ + C V++++ G++ E G+ +L+ ++G + +L
Sbjct: 1266 AHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1305
Score = 87.0 bits (214), Expect = 1e-16
Identities = 101/492 (20%), Positives = 203/492 (41%), Gaps = 44/492 (8%)
Query: 882 SSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFIL 941
S++ V+ K+L + G ++N S D+ L + + +L ++VV +
Sbjct: 192 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 251
Query: 942 VILAAVFPAVLLVVAS----LAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQG 997
+ + P+ L +A L + FFI + H +++++ ++ +R +TSS+
Sbjct: 252 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRAR------LTSSILR 305
Query: 998 LGIIHAYGKKESCITYHLLYFNC----ALRWFALRMDVLM---NILTFTVALLVTLSFSS 1050
+ E +L ALR L V + + TF VAL+V +
Sbjct: 306 NSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTL 365
Query: 1051 ISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYIS-------TCVPECTH 1103
++ ++ +++ L + + + F+ L++ +S C+ E
Sbjct: 366 VAENAMNAEKAFVT----LTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDP 421
Query: 1104 PLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSL 1163
+ + IT + + +P L +NL + G + +VG G+GKSSL
Sbjct: 422 GAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSL 481
Query: 1164 GMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTD 1223
AL + G + I+ + +PQ+ + +V N+ +
Sbjct: 482 LSALLGELSKVEGFVSIEGA-------------VAYVPQEAWVQNTSVVENVCFGQELDP 528
Query: 1224 EMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEA 1283
L +VLE ++ + PE + + E G N S G++Q L +ARA+ R + + LLD+
Sbjct: 529 PWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDP 588
Query: 1284 TASMDSKTDTLVQNTI---KDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEV 1340
A++D+ V N + +G T + + H L+ + D ++V+ NG + E +
Sbjct: 589 LAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQE 648
Query: 1341 LAEKPDSAFAML 1352
L ++ + +L
Sbjct: 649 LLQRKGALVCLL 660
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 575 bits (1481), Expect = e-163
Identities = 394/1200 (32%), Positives = 607/1200 (50%), Gaps = 148/1200 (12%)
Query: 218 GEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQ 277
GE LN+L +DS L A +P+ + + +G + G+ + ++ +PV
Sbjct: 335 GEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVN 394
Query: 278 MFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLE 337
+A A + + D RV+ + E L+ IR+IK WE++ ++ R RE L
Sbjct: 395 KVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLR 454
Query: 338 KAGFVQSGNS---ALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSIAIL 394
++ + A P+V +I I +T ++L+ +LTA F+ +A+ ++ +
Sbjct: 455 VIKYLDAACVYLWAALPVVISIVIFIT---YVLMGHQLTATKVFTALALVRMLILPLNNF 511
Query: 395 PFSIKAMAEANVSLRRMKKILI--DKSPPSYITQ-----------------PEDPDTVLL 435
P+ I + EA VSL R++ L + +P +Y + P +P TVL
Sbjct: 512 PWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLE 571
Query: 436 LANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSV 495
L A +W+ + SL++
Sbjct: 572 LHGALFSWDPVGT------------------------------------------SLETF 589
Query: 496 LHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT---LAYVSQQAWI 552
+ + V+KG ++GI G VG GKSSLLAA+ G++ +G VAV G +Q+ WI
Sbjct: 590 ISHLE--VKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWI 647
Query: 553 FHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRIS 612
+R+NILFG+ +D Q Y+ + C L DLS LP GD TE+GE+G+ LSGGQR RI+
Sbjct: 648 QFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIA 707
Query: 613 LARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVI 672
LARAVY +++LYLLDDPL+AVDA V H+ CI L T +L TH+ ++LE D V+
Sbjct: 708 LARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVL 767
Query: 673 LLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREED 732
L+E G + G E++ L+ A+ +A+ E+ E +
Sbjct: 768 LMEAGRLIRAGPPSEILP-------LVQ----------------AVPKAWAENGQESDSA 804
Query: 733 AGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGY 792
V P K EG E E + +L+Q ES +EG V Y Y KA G
Sbjct: 805 TAQSVQNPEKTK-EGLEEEQSTS--------GRLLQEESKKEGAVALHVYQAYWKAVGQG 855
Query: 793 LLSLFTVFLFLLMIGSAAFSNWWLGLWLD--KGSRMTCGPQGNRTMCEVGA-----VLAD 845
L +L +F LLM + ++WWL W+ K + Q + + +G +L
Sbjct: 856 L-ALAILFSLLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFS 914
Query: 846 IGQ-------------------HVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHD 886
G Y VY + + + +F TL A+++LH
Sbjct: 915 PGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHR 974
Query: 887 TVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAA 946
+ ++L +P++FF+ TPTGR++NRFS D+ D LPF L ++ +L +L +
Sbjct: 975 RLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGS 1034
Query: 947 VFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGK 1006
P +LL++ L++ ++ + R + +EL+++ +++ SP ++H+ ++ GL ++ A G
Sbjct: 1035 GLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGA 1094
Query: 1007 ----KESCITYHLLYFNC------ALRWFALRMDVLMNILTFTVA--LLVTLSFSSISTS 1054
+E + L C ++W +R+ ++ + +A LV +
Sbjct: 1095 TYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPG 1154
Query: 1055 SKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECT-HPLKVGTCPKD 1113
GLSLSY + L+GLL V + T+T+A SVE L EY E PL++GT
Sbjct: 1155 LVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGT---G 1211
Query: 1114 WPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEP 1173
W ++G + F+D + YR P LD + +Q G+ +GIVGRTGSGKSSL + LFRL+EP
Sbjct: 1212 WLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEP 1271
Query: 1174 ASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERT 1233
+SG + +D VD L L LR++L +IPQ+P LF GTVR NLDP H D LWQ L++
Sbjct: 1272 SSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQC 1331
Query: 1234 FMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDT 1293
+ + I + L E+ E G + S+G+RQLLC+ARALL ++KI+ +DEATAS+D KTD
Sbjct: 1332 HLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQ 1390
Query: 1294 LVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLL 1353
L+Q TI F TVLTIAHRLNT+LN D VLV++ G+V+E D P L +P S F LL
Sbjct: 1391 LLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLL 1450
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 567 bits (1461), Expect = e-161
Identities = 394/1370 (28%), Positives = 680/1370 (49%), Gaps = 130/1370 (9%)
Query: 51 LLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVG--PEK 108
LLS AT+ W+ +++ +++ + + + L + TN + ++E+ +V P +
Sbjct: 222 LLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNR 281
Query: 109 A-SLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCI 167
S+ +++ +L+ L ++ GP + I I+Q+ T G+
Sbjct: 282 TPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGP-LCISGIVQRVNETQNGTNNTTGISE 340
Query: 168 ALFATEFTK-------VFFWAL---------AWAINYRTAIRLKVALSTLVFENLVSFKT 211
L + EF + + F AL ++ + T I L+ AL +++ ++ T
Sbjct: 341 TLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLST 400
Query: 212 ----LTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGI 267
+ +++G++ N+++ ++ L CP +P+ ++ + +LG +AL+G
Sbjct: 401 SNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGA 460
Query: 268 SVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQD 327
+V V+ P+Q F+A + ++S + + +R++ NE L I+L+K+YAWE F ++++
Sbjct: 461 AVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEE 520
Query: 328 IRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPV-AFSVIAMFNV 386
R +E L+ S + + + A++ T H P AF+ +++F++
Sbjct: 521 TRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHI 580
Query: 387 MKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWE-- 444
+ + +L ++ +A +S++++ + L+ E D ++L +E
Sbjct: 581 LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSD---------EIGDDSWRTGESSLPFESC 631
Query: 445 --HEASRKSTPKKLQNQKRHLCKKQRSEAY---SERSPPAKGATGPEEQSDSLKSVLHSI 499
H + T + Q + HL ++S +E A T S + L +I
Sbjct: 632 KKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNI 691
Query: 500 SFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG-----------------T 542
+ G++ I G VG GKSSLL A+LG+MQ +G V + +
Sbjct: 692 DIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYS 751
Query: 543 LAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLN 602
+AY +Q+ W+ + V ENI FG ++ QRY+ C LQ D+ LP+GD TEIGERG+N
Sbjct: 752 VAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGIN 811
Query: 603 LSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRG--KTVVLVTH 660
LSGGQRQRI +ARA+Y + + LDDP SA+D H+ H+ +E I K L+ +T+VLVTH
Sbjct: 812 LSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTH 871
Query: 661 QLQFLESCDEVILLEDGEICEKGTHKELME---ERGRYAKLIHNLRGLQF-KDPEHLYNA 716
+LQ+L D +I ++DG + +GT K++ E + K + N + + KD E
Sbjct: 872 KLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTT 931
Query: 717 AMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGT 776
+ + + RE A + ++DE +E E E D + ++T+ P
Sbjct: 932 LERKTLRRAMYSREAKAQM------EDEDEEEEEE---EDEDDNMSTVMRLRTKMP---- 978
Query: 777 VTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQ----- 831
WKT Y+ SGG+ L + +F LL ++WL W + S G
Sbjct: 979 --WKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYY 1035
Query: 832 --GNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVF 889
G +C G L + +W+ L A+ +LH +
Sbjct: 1036 VAGFSILCGAGIFLCLVTSLTVEWM----------------------GLTAAKNLHHNLL 1073
Query: 890 DKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFP 949
+KI+ P+ FFDTTP G ++NRFS D + +D +P E+ + + + + +++ P
Sbjct: 1074 NKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATP 1133
Query: 950 AVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKK-- 1007
L+ + L V F+ + + F ++L+++++ ++ P H + + +GL I A+ +
Sbjct: 1134 VFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETR 1193
Query: 1008 ------ESCITYHL--LYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSK--- 1056
E T ++ L+ + A RW +R D L +++T S +SIS SS
Sbjct: 1194 FKQRMLELTDTNNIAYLFLSAANRWLEVRTDYL------GACIVLTASIASISGSSNSGL 1247
Query: 1057 -GLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWP 1115
GL L Y + ++ L VR + + + +V+ + +++ + P+ WP
Sbjct: 1248 VGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWP 1307
Query: 1116 SRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPAS 1175
GEI D +RY +N VL + I+ GQ VGI GRTGSGKSSL +A FR+V+
Sbjct: 1308 QEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFD 1367
Query: 1176 GTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFM 1235
G I ID +DI L L LR++L++I QDP+LF G++R+NLDP TD+ LW+ LE +
Sbjct: 1368 GKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQL 1427
Query: 1236 RDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLV 1295
++ + LP L A VTE GENFSVG+RQL C+ARA +R S I+++DEATAS+D T+ ++
Sbjct: 1428 KNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENIL 1487
Query: 1296 QNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDK-PEVLAEK 1344
Q + AF TV+TIAHR++++++ VLV G ++E D P +LA K
Sbjct: 1488 QKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHK 1537
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 558 bits (1437), Expect = e-158
Identities = 388/1363 (28%), Positives = 669/1363 (49%), Gaps = 152/1363 (11%)
Query: 51 LLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVG--PEK 108
LLS AT+ W+ +++ +++ + + + L + TN + ++E+ +V P +
Sbjct: 222 LLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNR 281
Query: 109 A-SLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCI 167
S+ +++ +L+ L ++ GP + I I+Q+ T G+
Sbjct: 282 TPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGP-LCISGIVQRVNETQNGTNNTTGISE 340
Query: 168 ALFATEFTK-------VFFWAL---------AWAINYRTAIRLKVALSTLVFENLVSFKT 211
L + EF + + F AL ++ + T I L+ AL +++ ++ T
Sbjct: 341 TLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLST 400
Query: 212 ----LTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGI 267
+ +++G++ N+++ ++ L CP +P+ ++ + +LG +AL+G
Sbjct: 401 SNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGA 460
Query: 268 SVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQD 327
+V V+ P+Q F+A + ++S + + +R++ NE L I+L+K+YAWE F ++++
Sbjct: 461 AVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEE 520
Query: 328 IRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPV-AFSVIAMFNV 386
R +E L+ S + + + A++ T H P AF+ +++F++
Sbjct: 521 TRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHI 580
Query: 387 MKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHE 446
+ + +L ++ +A +S++++ + L+ E D ++L +E
Sbjct: 581 LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSD---------EIGDDSWRTGESSLPFES- 630
Query: 447 ASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKG 506
CKK + G + L +I + G
Sbjct: 631 -----------------CKKHTGVVTNGYFSWGSGL-----------ATLSNIDIRIPTG 662
Query: 507 KILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG-----------------TLAYVSQQ 549
++ I G VG GKSSLL A+LG+MQ +G V + ++AY +Q+
Sbjct: 663 QLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQK 722
Query: 550 AWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQ 609
W+ + V ENI FG ++ QRY+ C LQ D+ LP+GD TEIGERG+NLSGGQRQ
Sbjct: 723 PWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQ 782
Query: 610 RISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRG--KTVVLVTHQLQFLES 667
RI +ARA+Y + + LDDP SA+D H+ H+ +E I K L+ +T+VLVTH+LQ+L
Sbjct: 783 RICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTH 842
Query: 668 CDEVILLEDGEICEKGTHKELME---ERGRYAKLIHNLRGLQF-KDPEHLYNAAMVEAFK 723
D +I ++DG + +GT K++ E + K + N + + KD E + +
Sbjct: 843 ADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLR 902
Query: 724 ESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYH 783
+ RE A + ++DE +E E E D + ++T+ P WKT
Sbjct: 903 RAMYSREAKAQM------EDEDEEEEEE---EDEDDNMSTVMRLRTKMP------WKTCW 947
Query: 784 TYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQ-------GNRTM 836
Y+ SGG+ L + +F LL ++WL W + S G G +
Sbjct: 948 RYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSIL 1006
Query: 837 CEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSP 896
C G L + +W+ L A+ +LH + +KI+ P
Sbjct: 1007 CGAGIFLCLVTSLTVEWM----------------------GLTAAKNLHHNLLNKIILGP 1044
Query: 897 MSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVA 956
+ FFDTTP G ++NRFS D + +D +P E+ + + + + +++ P L+ +
Sbjct: 1045 IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL 1104
Query: 957 SLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKK--------E 1008
L V F+ + + F ++L+++++ ++ P H + + +GL I A+ + E
Sbjct: 1105 PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE 1164
Query: 1009 SCITYHL--LYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSK----GLSLSY 1062
T ++ L+ + A RW +R D L +++T S +SIS SS GL L Y
Sbjct: 1165 LTDTNNIAYLFLSAANRWLEVRTDYL------GACIVLTASIASISGSSNSGLVGLGLLY 1218
Query: 1063 IIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITF 1122
+ ++ L VR + + + +V+ + +++ + P+ WP GEI
Sbjct: 1219 ALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKI 1278
Query: 1123 RDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDE 1182
D +RY +N VL + I+ GQ VGI GRTGSGKSSL +A FR+V+ G I ID
Sbjct: 1279 HDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDG 1338
Query: 1183 VDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKL 1242
+DI L L LR++L++I QDP+LF G++R+NLDP TD+ LW+ LE +++ + L
Sbjct: 1339 IDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSL 1398
Query: 1243 PEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDA 1302
P L A VTE GENFSVG+RQL C+ARA +R S I+++DEATAS+D T+ ++Q + A
Sbjct: 1399 PGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTA 1458
Query: 1303 FKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDK-PEVLAEK 1344
F TV+TIAHR++++++ VLV G ++E D P +LA K
Sbjct: 1459 FADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHK 1501
Score = 84.3 bits (207), Expect = 7e-16
Identities = 56/224 (25%), Positives = 107/224 (47%), Gaps = 15/224 (6%)
Query: 490 DSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG-------- 541
++LK VL + ++ G+ +GICG GSGKSSL A + + G + ++G
Sbjct: 1287 NNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1346
Query: 542 -----TLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEI 596
L+ + Q +F G++R N+ K R + + L+ + +LP G +
Sbjct: 1347 HTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVV 1406
Query: 597 GERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVV 656
E G N S GQRQ LARA + ++D+ +++D +++ ++ + +TVV
Sbjct: 1407 TEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKVVMTAFADRTVV 1465
Query: 657 LVTHQLQFLESCDEVILLEDGEICEKGTHKELM-EERGRYAKLI 699
+ H++ + V++ +G + E T L+ + G ++ L+
Sbjct: 1466 TIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 439 bits (1130), Expect = e-123
Identities = 289/926 (31%), Positives = 480/926 (51%), Gaps = 94/926 (10%)
Query: 32 MIPVRPCARLAPNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAK 91
M+PV + PNP+ DA L S F WL P+ G+++RL D + + D S +
Sbjct: 1 MLPVYQ--EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
Query: 92 RFRVLWDEEVARV--GPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQIL 149
+ WD+EV R +K SL+ + K L+ + ++ I P+ L +I+
Sbjct: 59 ELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFL-GKII 117
Query: 150 QQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYR--------TAIRLKVALSTL 201
E V + A +AT T F L AI + +RL+VA+ +
Sbjct: 118 NYFENYDPMDSVALNTAYA-YATVLT---FCTLILAILHHLYFYHVQCAGMRLRVAMCHM 173
Query: 202 VFENLVSFKTLT--HISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFIL 259
++ + + + G+++N+LS+D + +F P+ + A + +
Sbjct: 174 IYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEI 233
Query: 260 GPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEK 319
G + L G++V +I +P+Q KL S+ R TD R++TMNE +T IR+IKMYAWEK
Sbjct: 234 GISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEK 293
Query: 320 SFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFS 379
SF+N I ++R++E + ++ ++ N A S I + +T + ++LL +TA F
Sbjct: 294 SFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFV 353
Query: 380 VIAMFNVMKFSIAIL-PFSIKAMAEANVSLRRMKK-ILIDKSPPSYITQPEDPDTVLLLA 437
+ ++ ++ ++ + P +I+ ++EA VS+RR++ +L+D+ P D ++ +
Sbjct: 354 AVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQ 413
Query: 438 NATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLH 497
+ T W+ +AS T L
Sbjct: 414 DFTAFWD-KASETPT-------------------------------------------LQ 429
Query: 498 SISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNV 557
+SF VR G++L + G VG+GKSSLL+A+LG++ G+V+V+G +AYVSQQ W+F G +
Sbjct: 430 GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTL 489
Query: 558 RENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAV 617
R NILFG+KY+ +RY+ ++ C L+KDL L GDLT IG+RG LSGGQ+ R++LARAV
Sbjct: 490 RSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAV 549
Query: 618 YSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDG 677
Y D +YLLDDPLSAVDA V +H+FE CI + L K +LVTHQLQ+L++ ++++L+DG
Sbjct: 550 YQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDG 609
Query: 678 EICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIV 737
++ +KGT+ E ++ + L+ + P F ES ++
Sbjct: 610 KMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQS----- 664
Query: 738 LAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLF 797
+ + KD ES+ +E V + E E+ EG V ++ Y Y +A ++
Sbjct: 665 -SRPSLKDGALESQ-DTENVPVTLSE------ENRSEGKVGFQAYKNYFRAGAHWI---- 712
Query: 798 TVFLFLLMIGSAA-----FSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQ 852
VF+FL+++ +AA +WWL W +K S + N T+ G V + + Y
Sbjct: 713 -VFIFLILLNTAAQVAYVLQDWWLSYWANKQSML------NVTVNGGGNVTEKLDLNWYL 765
Query: 853 WVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRF 912
+Y+ V ++FG+ + + + +S +LH+ +F+ ILK+P+ FFD P GR++NRF
Sbjct: 766 GIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRF 825
Query: 913 SKDMDELDVRLPFHAENFLQQFFMVV 938
SKD+ LD LP +F+Q++ + V
Sbjct: 826 SKDIGHLDDLLPLTFLDFIQRWDLAV 851
Score = 66.6 bits (161), Expect = 2e-10
Identities = 42/199 (21%), Positives = 98/199 (49%), Gaps = 14/199 (7%)
Query: 1137 LDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTK 1196
L L+ ++ G+ + +VG G+GKSSL A+ + P+ G + + +
Sbjct: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSV-------------HGR 474
Query: 1197 LTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGEN 1256
+ + Q P +F GT+R N+ + + E +V++ ++ + L + + + G
Sbjct: 475 IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTT 534
Query: 1257 FSVGERQLLCVARALLRNSKIILLDEATASMDSKTDT-LVQNTIKDAFKGCTVLTIAHRL 1315
S G++ + +ARA+ +++ I LLD+ +++D++ L + I + + H+L
Sbjct: 535 LSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQL 594
Query: 1316 NTVLNCDHVLVMENGKVIE 1334
+ +L++++GK+++
Sbjct: 595 QYLKAASQILILKDGKMVQ 613
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 429 bits (1102), Expect = e-119
Identities = 255/726 (35%), Positives = 403/726 (55%), Gaps = 48/726 (6%)
Query: 653 KTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGL-QFKDPE 711
KT +LVTH + +L D +I++ G+I E G+++EL+ G +A+ + Q +D E
Sbjct: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
Query: 712 HLYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDT------------ 759
+ KE+ ++ + G++V ++ + + S + S D
Sbjct: 765 ENGVTGVSGPGKEA---KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQK 821
Query: 760 ----KVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWW 815
K +L++ + Q G V Y Y+KA G ++ S ++FLF+ SA SN+W
Sbjct: 822 AEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFI-SFLSIFLFMCNHVSALASNYW 880
Query: 816 LGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTK 875
L LW D P N T L+ G + VF V+ G +
Sbjct: 881 LSLWTDD-------PIVNGTQEHTKVRLSVYGA---LGISQGIAVFGYSMAVSIGGI--- 927
Query: 876 TTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFF 935
+AS LH + IL+SPMSFF+ TP+G L+NRFSK++D +D +P + F+ F
Sbjct: 928 ---LASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLF 984
Query: 936 MVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSM 995
V+ +++ P +++ L + +F + R + ++LK++E+VSRSP ++H ++
Sbjct: 985 NVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETL 1044
Query: 996 QGLGIIHAYGKKESCITYHLLYFN----------CALRWFALRMDVLMNILTFTVALLVT 1045
G+ +I A+ ++E I L + A RW A+R++ + N + AL
Sbjct: 1045 LGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAV 1104
Query: 1046 LSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPL 1105
+S S+S GLS+SY +Q++ L VR +E + +VE L+EY T E +
Sbjct: 1105 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQI 1163
Query: 1106 KVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGM 1165
+ P WP G + FR+Y +RYR++ VL +N+ I G+ VGIVGRTG+GKSSL +
Sbjct: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
Query: 1166 ALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEM 1225
LFR+ E A G I ID ++I + L DLR K+T+IPQDPVLF G++R NLDPF ++DE
Sbjct: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283
Query: 1226 LWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATA 1285
+W LE ++D + LP+KL E E GEN SVG+RQL+C+ARALLR +KI++LDEATA
Sbjct: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343
Query: 1286 SMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKP 1345
++D +TD L+Q+TI+ F+ CTVLTIAHRLNT+++ V+V++ G++ E+ P L ++
Sbjct: 1344 AVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1403
Query: 1346 DSAFAM 1351
++M
Sbjct: 1404 GLFYSM 1409
Score = 163 bits (413), Expect = 9e-40
Identities = 133/557 (23%), Positives = 241/557 (43%), Gaps = 93/557 (16%)
Query: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVA 102
P P A LS TF W+T ++V+GYRQ L L L+ D+S+ W +E A
Sbjct: 207 PCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECA 266
Query: 103 RV-----------------------------------GPEKA---SLSHVVWKFQRTRVL 124
+ P+K SL V++K L
Sbjct: 267 KTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFL 326
Query: 125 MDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAW 184
M + +M GP IL +++ T W G + LF T + +
Sbjct: 327 MSFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYF 385
Query: 185 AINYRTAIRLKVALSTLVFEN--LVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPA 242
I + + +R+K A+ V+ +++ +VGE++N++S D+ + A + +
Sbjct: 386 HICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIW 445
Query: 243 TIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTM 302
+ P+ ++ + LGP+ L G++V V+ +PV MA ++ + + D R++ M
Sbjct: 446 SAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLM 505
Query: 303 NEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTL 362
NE L I+++K+YAWE +F + + IR+ E K+L+K+ ++ + + + + T
Sbjct: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTF 565
Query: 363 SCHILLRRK--LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILI--DK 418
+ ++ + L A AF +A+FN+++F + ILP I ++ +A+VSL+R++ L +
Sbjct: 566 AVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEEL 625
Query: 419 SPPSYITQPEDP---DTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSER 475
P S +P + + NAT TW +
Sbjct: 626 EPDSIERRPVKDGGGTNSITVRNATFTW-----------------------------ARS 656
Query: 476 SPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKG 535
PP L+ I+F + +G ++ + G VG GKSSLL+ALL +M +G
Sbjct: 657 DPP----------------TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG 700
Query: 536 VVAVNGTLAYVSQQAWI 552
VA+ + +++
Sbjct: 701 HVAIKTRILVTHSMSYL 717
Score = 90.5 bits (223), Expect = 1e-17
Identities = 62/219 (28%), Positives = 107/219 (48%), Gaps = 14/219 (6%)
Query: 490 DSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------- 542
+ L VL I+ + G+ +GI G G+GKSSL L + +G + ++G
Sbjct: 1189 EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGL 1248
Query: 543 ------LAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEI 596
+ + Q +F G++R N+ +Y + ++ + L+ +S LP E
Sbjct: 1249 HDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHEC 1308
Query: 597 GERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVV 656
E G NLS GQRQ + LARA+ ++ +LD+ +AVD + + I+ TV+
Sbjct: 1309 AEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVL 1367
Query: 657 LVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRY 695
+ H+L + VI+L+ GEI E G +L+++RG +
Sbjct: 1368 TIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1406
Score = 39.3 bits (90), Expect = 0.026
Identities = 22/69 (31%), Positives = 33/69 (47%)
Query: 1112 KDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLV 1171
KD IT R+ + + P L+ + +I G V +VG+ G GKSSL AL +
Sbjct: 636 KDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEM 695
Query: 1172 EPASGTIFI 1180
+ G + I
Sbjct: 696 DKVEGHVAI 704
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 280 bits (716), Expect = 7e-75
Identities = 181/600 (30%), Positives = 302/600 (50%), Gaps = 50/600 (8%)
Query: 778 TWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMC 837
TW TY YI SL V ++ L+I A + + LWL + + +GN T
Sbjct: 845 TWNTYLRYITVHK----SLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQ--DKGNSTHS 898
Query: 838 E---VGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILK 894
++ + ++Y +L G +G T + S LH + +L+
Sbjct: 899 RNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQ 958
Query: 895 SPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLV 954
+PMS +T G ++NRFSKD+ LD LP +F+Q +V+ + ++A + P + +
Sbjct: 959 APMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVA 1018
Query: 955 VASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKK------- 1007
+ V F +L F + Q+LK++E+ RSP FTH+ +S++GL + A+G++
Sbjct: 1019 TVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLF 1078
Query: 1008 ESCITYH----LLYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKG-----L 1058
+ H LY + LRWF +R++++ V + ++F SI T+ +G +
Sbjct: 1079 HKALNLHTANWFLYLS-TLRWFQMRIEMIF------VIFFIAVTFISILTTGEGEGRVGI 1131
Query: 1059 SLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVP----ECTHPLKVGTCPKD- 1113
L+ + + LQ V + + + SV + ++I + T P K G K
Sbjct: 1132 ILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVM 1191
Query: 1114 ------------WPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKS 1161
WPS G++T +D +Y + +L++++ +I GQ VG++GRTGSGKS
Sbjct: 1192 IIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKS 1251
Query: 1162 SLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESH 1221
+L A RL+ G I ID V ++L+ R VIPQ +F GT R NLDP+E
Sbjct: 1252 TLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQW 1310
Query: 1222 TDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLD 1281
+D+ +W+V + +R I + P KL + + G S G +QL+C+AR++L +KI+LLD
Sbjct: 1311 SDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLD 1370
Query: 1282 EATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVL 1341
E +A +D T +++ T+K AF CTV+ HR+ +L C LV+E KV ++D + L
Sbjct: 1371 EPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKL 1430
Score = 263 bits (672), Expect = 8e-70
Identities = 169/655 (25%), Positives = 323/655 (49%), Gaps = 35/655 (5%)
Query: 44 NPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVAR 103
+P++ A ++S FSW P++ KGYRQRL + + + + DS+D +++ WD E+A
Sbjct: 4 SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELAS 63
Query: 104 VGPEK---ASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVW 160
K A W+F + + + + +G +I + + ER+ ++
Sbjct: 64 KKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA-IY 122
Query: 161 VGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENLV--SFKTLTHISVG 218
+GIGLC+ T + A+ + +++++A+ +L+++ + S + L IS+G
Sbjct: 123 LGIGLCLLFIVR--TLLLHPAIFGL--HHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIG 178
Query: 219 EVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQM 278
+++++LS++ E P+ + + +L +A G+ ++ Q
Sbjct: 179 QLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQA 238
Query: 279 FMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEK 338
+ ++ +R +R+ +E + I+ +K Y WE++ I+++R+ E KL K
Sbjct: 239 GLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
Query: 339 AGFVQSGNSALAPIVSTIAIVLTLSCHILLR----RKLTAPVAFSVIAMFNVMKFSIAIL 394
A +V+ NS+ + L++ + L++ RK+ ++F ++ V +
Sbjct: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQ----F 354
Query: 395 PFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTV-LLLANATLTWEHEASRKSTP 453
P++++ ++ ++ +++ L Y T + T +++ N T WE
Sbjct: 355 PWAVQTWYDSLGAINKIQDFL---QKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEK 411
Query: 454 KKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICG 513
K N R S +S S VL I+F + +G++L + G
Sbjct: 412 AKQNNNNRKTSNGDDSLFFSNFSLLGT-------------PVLKDINFKIERGQLLAVAG 458
Query: 514 NVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQ 573
+ G+GK+SLL ++G+++ +G + +G +++ SQ +WI G ++ENI+FG YD RY+
Sbjct: 459 STGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYR 518
Query: 574 HTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAV 633
++ C L++D+S D +GE G+ LSGGQR RISLARAVY D LYLLD P +
Sbjct: 519 SVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYL 578
Query: 634 DAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKEL 688
D K +FE C+ K + KT +LVT +++ L+ D++++L +G GT EL
Sbjct: 579 DVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
Score = 88.6 bits (218), Expect = 4e-17
Identities = 61/255 (23%), Positives = 123/255 (48%), Gaps = 18/255 (7%)
Query: 494 SVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG------------ 541
++L +ISF + G+ +G+ G GSGKS+LL+A L + + G + ++G
Sbjct: 1225 AILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDSITLQQWR 1283
Query: 542 -TLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
+ Q+ +IF G R+N+ E++ Q GL+ + P + + G
Sbjct: 1284 KAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
LS G +Q + LAR+V S ++ LLD+P + +D V + +K+ TV+L H
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADCTVILCEH 1402
Query: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLI---HNLRGLQFKDPEHLYNAA 717
+++ + C + +++E+ ++ + + ++L+ ER + + I ++ ++ +
Sbjct: 1403 RIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKP 1462
Query: 718 MVEAFKESPAEREED 732
+ A KE E +D
Sbjct: 1463 QIAALKEETEEEVQD 1477
Score = 67.4 bits (163), Expect = 9e-11
Identities = 97/498 (19%), Positives = 200/498 (40%), Gaps = 80/498 (16%)
Query: 883 SLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILV 942
++ ++ K LK D G+L++ S ++++ D L L F + + V
Sbjct: 155 AMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLA------LAHFVWIAPLQV 208
Query: 943 -ILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTH---ITSSM-QG 997
+L + +L A +GF I+L +F G+ + R+ + ITS M +
Sbjct: 209 ALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIEN 268
Query: 998 LGIIHAYGKKESCITY----------------HLLYFNCALRWFALRMDVLMNILTFTVA 1041
+ + AY +E+ ++ YFN + +F+ V +++L + +
Sbjct: 269 IQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALI 328
Query: 1042 -------LLVTLSFSSISTSSKGLSLSYIIQ--------LSGLLQVCVRTGTET-QAKFT 1085
+ T+SF + + + +Q ++ + + +T + T
Sbjct: 329 KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLT 388
Query: 1086 SVELLREYISTCVPECTHPL-----KVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSL 1140
+ E++ E ++ E L + K + F ++ + TP VL +
Sbjct: 389 TTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLL---GTP-VLKDI 444
Query: 1141 NLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVI 1200
N I+ GQ + + G TG+GK+SL M + +EP+ G I +++
Sbjct: 445 NFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKI-------------KHSGRISFC 491
Query: 1201 PQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVG 1260
Q + GT++ N+ S+ + V++ + + I K EK + E G S G
Sbjct: 492 SQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGG 551
Query: 1261 ERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGC--------TVLTIA 1312
+R + +ARA+ +++ + LLD +D T+ K+ F+ C T + +
Sbjct: 552 QRARISLARAVYKDADLYLLDSPFGYLDVLTE-------KEIFESCVCKLMANKTRILVT 604
Query: 1313 HRLNTVLNCDHVLVMENG 1330
++ + D +L++ G
Sbjct: 605 SKMEHLKKADKILILHEG 622
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 240 bits (612), Expect = 8e-63
Identities = 264/1150 (22%), Positives = 488/1150 (42%), Gaps = 151/1150 (13%)
Query: 258 ILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAW 317
IL + ++G+S V AK+ S+F +L K E L IR + +
Sbjct: 218 ILAISPVLGLSAAV--------WAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGG 269
Query: 318 EKS----FTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLT 373
+K + +++ +R K A S +A I ++ A+ ++L + +
Sbjct: 270 QKKELERYNKNLEEAKRIGIKKAITANI--SIGAAFLLIYASYALAFWYGTTLVLSGEYS 327
Query: 374 APVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDK-SPPSYITQPEDPDT 432
+V + FS+ SI+A A A + + KI+ +K S SY PD
Sbjct: 328 IGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDN 387
Query: 433 VLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSL 492
+ L+ + H R E
Sbjct: 388 I-------------------KGNLEFRNVHFSYPSRKEV--------------------- 407
Query: 493 KSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT---------- 542
+L ++ V+ G+ + + GN G GKS+ + + +G+V+V+G
Sbjct: 408 -KILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFL 466
Query: 543 ---LAYVSQQAWIFHGNVRENILFG-EKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
+ VSQ+ +F + ENI +G E + V+ + LP+ T +GE
Sbjct: 467 REIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGE 526
Query: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
RG LSGGQ+QRI++ARA+ + ++ LLD+ SA+D + V + + K +G+T +++
Sbjct: 527 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAVVQVALDKARKGRTTIVI 585
Query: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAM 718
H+L + + D + +DG I EKG H ELM+E+G Y KL+ + E+ + +
Sbjct: 586 AHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESK 645
Query: 719 VEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVT 778
E + + + +I K + S GS+ D K+ + + P
Sbjct: 646 SEIDALEMSSNDSRSSLI------RKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSF-- 697
Query: 779 WKTYHTYIKASGGYLLSLFTVFLFL-LMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMC 837
W+ + +++ +F + L A + +G++ +R+ P+ R
Sbjct: 698 WRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVF----TRID-DPETKRQ-- 750
Query: 838 EVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPM 897
+++ ++ A + + +GF F K + + L VF +L+ +
Sbjct: 751 ---------NSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDV 801
Query: 898 SFFDT--TPTGRLMNRFSKDMDE----LDVRLPFHAENFLQQFFMVVFILVI---LAAVF 948
S+FD TG L R + D + + RL +N ++ + L +
Sbjct: 802 SWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLL 861
Query: 949 PAVLLVVASLAVGFFILL---------------RIFHRGVQELKKVENVSRSPWFTHI-T 992
A++ ++A V +L +I ++ + V ++++ F H+
Sbjct: 862 LAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYA 921
Query: 993 SSMQ-----GLGIIHAYGKKESCITYHLLYFNCALRWFALRMDVLMNILTFTVALLVTLS 1047
S+Q L H +G S T ++YF+ A + V +++F LLV
Sbjct: 922 QSLQVPYRNSLRKAHIFGITFS-FTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLV--- 977
Query: 1048 FSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKV 1107
FS++ + + QV +AK ++ ++ T P
Sbjct: 978 FSAVVFGAMAVG-----------QVSSFAPDYAKAKISAAHIIMIIEKT--PLIDSYSTE 1024
Query: 1108 GTCPKDWPSRGEITFRDYQMRY--RDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGM 1165
G P G +TF + Y R + P VL L+L ++ GQT+ +VG +G GKS++
Sbjct: 1025 GLMPNTL--EGNVTFGEVVFNYPTRPDIP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1081
Query: 1166 ALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNL---DPFESHT 1222
L R +P +G + +D +I L+++ LR L ++ Q+P+LF ++ N+ D +
Sbjct: 1082 LLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVS 1141
Query: 1223 DEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDE 1282
E + + + + I LP K +V + G S G++Q + +ARAL+R I+LLDE
Sbjct: 1142 QEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDE 1201
Query: 1283 ATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLA 1342
AT+++D++++ +VQ + A +G T + IAHRL+T+ N D ++V +NG+V E + L
Sbjct: 1202 ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1261
Query: 1343 EKPDSAFAML 1352
+ F+M+
Sbjct: 1262 AQKGIYFSMV 1271
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 223 bits (569), Expect = 7e-58
Identities = 221/898 (24%), Positives = 393/898 (43%), Gaps = 125/898 (13%)
Query: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
+L ++ V+ G+ + + G+ G GKS+ + + +G + ++G
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
Query: 543 -LAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
+ VSQ+ +F + ENI +G + V+ + + LP T +GERG
Sbjct: 471 IIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERG 530
Query: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
LSGGQ+QRI++ARA+ + ++ LLD+ SA+D V + + K G+T +++ H
Sbjct: 531 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAH 589
Query: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIH-NLRGLQFKDPEHLYNAAMV 719
+L + + D + EDG I E+G+H ELM++ G Y KL++ G Q + E N
Sbjct: 590 RLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELN---- 645
Query: 720 EAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTW 779
E A R +AP K T ++++ + L E V
Sbjct: 646 ---DEKAATR--------MAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPP 694
Query: 780 KTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEV 839
++ +K + T + + ++ A +N L P + E+
Sbjct: 695 VSFLKVLKLNK-------TEWPYFVVGTVCAIANGGLQ------------PAFSVIFSEI 735
Query: 840 GAVLADIGQHVYQWVYTASMVFMLVFGVT-------KGFVFTKTTLMASSSLHDTVFDKI 892
A+ V Q + L G+ +GF F K + + L F +
Sbjct: 736 IAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAM 795
Query: 893 LKSPMSFFDT--TPTGRLMNRFSKDMDELD----VRLPFHAENF--LQQFFMVVFIL--- 941
L+ MS+FD TG L R + D ++ RL A+N L ++ FI
Sbjct: 796 LRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQ 855
Query: 942 --VILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLG 999
++L AV P ++ S V +L R +EL+ ++ T +++ +
Sbjct: 856 LTLLLLAVVP---IIAVSGIVEMKLLAGNAKRDKKELEAAGKIA--------TEAIENIR 904
Query: 1000 IIHAYGKKESCITYHLLYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLS 1059
+ + ++ + ++ R F+ I+ VAL SF+ +K LS
Sbjct: 905 TVVSLTQERKFESMYVEKLYGPYRVFSA-------IVFGAVALGHASSFAPDYAKAK-LS 956
Query: 1060 LSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGE 1119
+++ L F L+ Y G P + G
Sbjct: 957 AAHLFML-----------------FERQPLIDSYSEE-----------GLKPDKF--EGN 986
Query: 1120 ITFRDYQMRY--RDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGT 1177
ITF + Y R N P VL L+L ++ GQT+ +VG +G GKS++ L R +P +GT
Sbjct: 987 ITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGT 1045
Query: 1178 IFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNL---DPFESHTDEMLWQVLERTF 1234
+ +D + L+++ LR +L ++ Q+P+LF ++ N+ D + + + +
Sbjct: 1046 VLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAAN 1105
Query: 1235 MRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTL 1294
+ I LP K + V + G S G++Q + +ARAL+R +I+LLDEAT+++D++++ +
Sbjct: 1106 IHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKV 1165
Query: 1295 VQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAML 1352
VQ + A +G T + IAHRL+T+ N D ++V +NG+V E + L + F+M+
Sbjct: 1166 VQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1223
Score = 149 bits (375), Expect = 2e-35
Identities = 88/238 (36%), Positives = 137/238 (57%), Gaps = 2/238 (0%)
Query: 1117 RGEITFRDYQMRYRDNTPL-VLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPAS 1175
+G + F D Y + +L LNL +QSGQTV +VG +G GKS+ + RL +P
Sbjct: 391 KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE 450
Query: 1176 GTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESH-TDEMLWQVLERTF 1234
GTI ID DI ++ LR + V+ Q+PVLF T+ N+ + T + + + ++
Sbjct: 451 GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEAN 510
Query: 1235 MRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTL 1294
+ IMKLP+K V E G S G++Q + +ARAL+RN KI+LLDEAT+++D++++
Sbjct: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
Query: 1295 VQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAML 1352
VQ + A +G T + IAHRL+TV N D + E+G ++E L +K F ++
Sbjct: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
Score = 118 bits (295), Expect = 4e-26
Identities = 67/228 (29%), Positives = 120/228 (52%), Gaps = 17/228 (7%)
Query: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
VL +S V+KG+ L + G+ G GKS+++ L G V ++G
Sbjct: 1004 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRA 1063
Query: 543 -LAYVSQQAWIFHGNVRENILFGEK---YDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
L VSQ+ +F ++ ENI +G+ + + + LP+ T +G+
Sbjct: 1064 QLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGD 1123
Query: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
+G LSGGQ+QRI++ARA+ Q+ LLD+ SA+D K V +E + K G+T +++
Sbjct: 1124 KGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIVI 1182
Query: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQ 706
H+L +++ D +++ ++G + E GTH++L+ ++G Y ++ G Q
Sbjct: 1183 AHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1230
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 189 bits (479), Expect = 2e-47
Identities = 190/854 (22%), Positives = 365/854 (42%), Gaps = 98/854 (11%)
Query: 543 LAYVSQQAWIFHGNVRENILFG-EKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGL 601
+ VSQ+ +F + NI +G + + + R + P T +GE+G
Sbjct: 19 IGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGA 78
Query: 602 NLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQ 661
+SGGQ+QRI++ARA+ + ++ +LD+ SA+D+ K + ++K +G+T ++V H+
Sbjct: 79 QMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKGRTTIVVAHR 137
Query: 662 LQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEA 721
L + S D ++ L+DG ++ E+G +A+L+ RGL Y+ M +
Sbjct: 138 LSTIRSADLIVTLKDG----------MLAEKGAHAELMAK-RGLY-------YSLVMSQD 179
Query: 722 FKESP---------AEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESP 772
K++ ER+ ++ + + D ++E ++ + +PE L++
Sbjct: 180 IKKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKL 239
Query: 773 QEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQG 832
+ + T G + +F++ ++ F N
Sbjct: 240 NKPEWPFVVLGTLASVLNGTVHPVFSIIFAKII---TMFGN------------------N 278
Query: 833 NRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKI 892
++T + A +Y ++ V V +G + + + + L F +
Sbjct: 279 DKTTLKHDA-------EIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAM 331
Query: 893 LKSPMSFFDT--TPTGRLMNRFSKDMDELD----VRLPFHAENFLQQFFMVV-------- 938
L +++FD TG L + D+ ++ R+ +N V+
Sbjct: 332 LYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWE 391
Query: 939 --FILVILAAVFPAVLLVVASLAVGFFILLR--IFHRG------VQELKKVENVSRSPWF 988
F+++ +A V ++ + GF + + H G ++ ++ + +++R F
Sbjct: 392 MTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAF 451
Query: 989 THITSSMQGLGIIHAYGKKESCITYHLLYFNCALRWFALRMDVLMNILTFTVALLVTLSF 1048
+ M L H K++ I F+ A +FA +
Sbjct: 452 EQMYEEM--LQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGM 509
Query: 1049 SSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVG 1108
+ T+ ++Y G V ++ ++ + L E K
Sbjct: 510 FIVFTA-----IAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPD 564
Query: 1109 TCPKDWPSRGEITFRDYQMRYRDNTPL-VLDSLNLNIQSGQTVGIVGRTGSGKSSLGMAL 1167
TC G + FR+ Y + +L L+L+I+ G+TV VG +G GKS+ L
Sbjct: 565 TC------EGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLL 618
Query: 1168 FRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLW 1227
RL +P G + D VD L+++ LR+++ ++PQ+PVLF ++ N+ ++ L
Sbjct: 619 QRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLD 678
Query: 1228 QVLERTF---MRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEAT 1284
++ E + I LPEK +V G S G++Q L +ARALL+ KI+LLDEAT
Sbjct: 679 EIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEAT 738
Query: 1285 ASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEK 1344
+++D+ ++ +VQ+ + A G T L + HRL+ + N D ++V+ NGK+ E + L
Sbjct: 739 SALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRN 798
Query: 1345 PDSAFAMLLAAEVR 1358
D F ++ A V+
Sbjct: 799 RDIYFKLVNAQSVQ 812
Score = 110 bits (274), Expect = 1e-23
Identities = 65/222 (29%), Positives = 117/222 (52%), Gaps = 17/222 (7%)
Query: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
+L +S + +GK + G+ G GKS+ + L +G V +G
Sbjct: 587 ILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRS 646
Query: 543 -LAYVSQQAWIFHGNVRENILFGEK---YDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
+A V Q+ +F+ ++ ENI +G+ + + + LP T++G
Sbjct: 647 QIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGL 706
Query: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
+G LSGGQ+QR+++ARA+ ++ LLD+ SA+D K V + + K G+T ++V
Sbjct: 707 KGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEK-VVQHALDKARTGRTCLVV 765
Query: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIH 700
TH+L +++ D +++L +G+I E+GTH+EL+ R Y KL++
Sbjct: 766 THRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVN 807
Score = 109 bits (273), Expect = 2e-23
Identities = 59/180 (32%), Positives = 106/180 (58%), Gaps = 1/180 (0%)
Query: 1180 IDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLD-PFESHTDEMLWQVLERTFMRDT 1238
+DE DI L++ R + V+ Q+PVLF T+ N+ + TDE + + D
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
Query: 1239 IMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNT 1298
IM+ P K V E G S G++Q + +ARAL+RN KI++LDEAT+++DS++ + VQ
Sbjct: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
Query: 1299 IKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEVR 1358
++ A KG T + +AHRL+T+ + D ++ +++G + E L K ++++++ +++
Sbjct: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIK 181
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 167 bits (424), Expect = 5e-41
Identities = 141/492 (28%), Positives = 233/492 (47%), Gaps = 30/492 (6%)
Query: 884 LHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVI 943
L ++F IL+ ++FFD T TG L+NR S D L + + + L+ + +
Sbjct: 247 LRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISM 306
Query: 944 LAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHA 1003
+ V P + V S+ I+ I+ R +++L KV S + + + + A
Sbjct: 307 MFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRA 366
Query: 1004 YGKKESCITYHLLYFNCALRW-----FA---------LRMDVLMNILTFTVALLVTLSFS 1049
+GK+ + I + + ++ FA L ++++ + + LL+ +
Sbjct: 367 FGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHM 426
Query: 1050 SISTSSKGLSLSYIIQLS--GLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKV 1107
++ S L ++ + +S GL A ELL E P
Sbjct: 427 TVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLER-------EPKLPFNE 479
Query: 1108 GTCPKDWPSRGEITFRDYQMRY--RDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGM 1165
G + +G + F++ Y R P+ D +L+I SG +VG +GSGKS++
Sbjct: 480 GVILNEKSFQGALEFKNVHFAYPARPEVPIFQD-FSLSIPSGSVTALVGPSGSGKSTVLS 538
Query: 1166 ALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLF----VGTVRYNLDPFESH 1221
L RL +PASGTI +D DI L+ LR+K+ + Q+P+LF + Y D S
Sbjct: 539 LLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSV 598
Query: 1222 TDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLD 1281
T E + +V E I P+ V E G S G++Q + +ARALL+N KI+LLD
Sbjct: 599 TAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLD 658
Query: 1282 EATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVL 1341
EAT+++D++ + LVQ + G TVL IAHRL+T+ N + V V++ GK+ E+ K E L
Sbjct: 659 EATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEEL 718
Query: 1342 AEKPDSAFAMLL 1353
KP+ + L+
Sbjct: 719 LSKPNGIYRKLM 730
Score = 114 bits (285), Expect = 6e-25
Identities = 67/224 (29%), Positives = 122/224 (54%), Gaps = 19/224 (8%)
Query: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG------------- 541
+ S + G + + G GSGKS++L+ LL G ++++G
Sbjct: 509 IFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRS 568
Query: 542 TLAYVSQQAWIFHGNVRENILFG----EKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIG 597
+ VSQ+ +F ++ ENI +G + Q V + N P G T +G
Sbjct: 569 KIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVG 628
Query: 598 ERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVL 657
E+G+ LSGGQ+QRI++ARA+ + ++ LLD+ SA+DA +++ +E + + + G+TV++
Sbjct: 629 EKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEALDRLMDGRTVLV 687
Query: 658 VTHQLQFLESCDEVILLEDGEICEKGTHKELMEE-RGRYAKLIH 700
+ H+L +++ + V +L+ G+I E G H+EL+ + G Y KL++
Sbjct: 688 IAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMN 731
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 152 bits (383), Expect = 3e-36
Identities = 137/523 (26%), Positives = 221/523 (42%), Gaps = 43/523 (8%)
Query: 855 YTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSK 914
Y S F + VF K + + VF + + F + TG L +
Sbjct: 197 YGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDR 256
Query: 915 DMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQ 974
+ L N L F V+ + +L A +V +G +
Sbjct: 257 GTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAF-------- 308
Query: 975 ELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYHLL-YFNCALRWFALRMDVLM 1033
V+ + W T M +S + Y + YFN R+ A R D +
Sbjct: 309 ------TVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNE-RYEAQRYDGFL 361
Query: 1034 NILTF----TVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAK--FTSV 1087
+ + L L+F + S GL+ ++ G++ + G +
Sbjct: 362 KTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQL 421
Query: 1088 ELLREYISTCVPECTHPL----------KVGTCPKD---------WPSRGEITFRDYQMR 1128
L ++ T E L KV T KD P + F +
Sbjct: 422 SLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFE 481
Query: 1129 YRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICIL 1188
Y + VL ++ + +G+ V IVG +GSGKS++ LFR EP G+I++ +I +
Sbjct: 482 YIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV 540
Query: 1189 SLEDLRTKLTVIPQDPVLFVGTVRYNLDPFE-SHTDEMLWQVLERTFMRDTIMKLPEKLQ 1247
SLE LR + V+PQD VLF T+ YNL S + E ++ V + + D I+++P
Sbjct: 541 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD 600
Query: 1248 AEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCT 1307
+V E G S GE+Q + +ARA+L++ +IL DEAT+S+DS T+ + +KD K T
Sbjct: 601 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT 660
Query: 1308 VLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFA 1350
+ IAHRL+TV++ D ++V++ GKV E L P S ++
Sbjct: 661 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYS 703
Score = 118 bits (296), Expect = 3e-26
Identities = 66/211 (31%), Positives = 115/211 (54%), Gaps = 15/211 (7%)
Query: 493 KSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG----------- 541
+ VL ISF V GK + I G GSGKS+++ L + QKG + + G
Sbjct: 486 QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESL 545
Query: 542 --TLAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
+ V Q A +FH + N+L+G + ++ GL + +P+G T++GE
Sbjct: 546 RRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGE 605
Query: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
RGL LSGG++QR+++ARA+ D + L D+ S++D+ + + +K ++ +T + +
Sbjct: 606 RGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDS-ITEETILGAMKDVVKHRTSIFI 664
Query: 659 THQLQFLESCDEVILLEDGEICEKGTHKELM 689
H+L + DE+I+L+ G++ E+GTH L+
Sbjct: 665 AHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 149 bits (375), Expect = 2e-35
Identities = 88/238 (36%), Positives = 137/238 (57%), Gaps = 2/238 (0%)
Query: 1117 RGEITFRDYQMRYRDNTPL-VLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPAS 1175
+G + F D Y + +L LNL +QSGQTV +VG +G GKS+ + RL +P
Sbjct: 391 KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE 450
Query: 1176 GTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESH-TDEMLWQVLERTF 1234
GTI ID DI ++ LR + V+ Q+PVLF T+ N+ + T + + + ++
Sbjct: 451 GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEAN 510
Query: 1235 MRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTL 1294
+ IMKLP+K V E G S G++Q + +ARAL+RN KI+LLDEAT+++D++++
Sbjct: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
Query: 1295 VQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAML 1352
VQ + A +G T + IAHRL+TV N D + E+G ++E L +K F ++
Sbjct: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
Score = 137 bits (345), Expect = 7e-32
Identities = 81/247 (32%), Positives = 141/247 (57%), Gaps = 13/247 (5%)
Query: 1118 GEITFRDYQMRY--RDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPAS 1175
G ITF + Y R N P VL L+L ++ GQT+ +VG +G GKS++ L R +P +
Sbjct: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
Query: 1176 GTIFID-------EVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNL---DPFESHTDEM 1225
GT+F+D + L+++ LR +L ++ Q+P+LF ++ N+ D + +
Sbjct: 1091 GTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 1150
Query: 1226 LWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATA 1285
+ + + I LP K + V + G S G++Q + +ARAL+R +I+LLDEAT+
Sbjct: 1151 IVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATS 1210
Query: 1286 SMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKP 1345
++D++++ +VQ + A +G T + IAHRL+T+ N D ++V +NG+V E + L +
Sbjct: 1211 ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK 1270
Query: 1346 DSAFAML 1352
F+M+
Sbjct: 1271 GIYFSMV 1277
Score = 115 bits (288), Expect = 3e-25
Identities = 67/235 (28%), Positives = 120/235 (51%), Gaps = 24/235 (10%)
Query: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALL--------------------GQMQLQK 534
VL +S V+KG+ L + G+ G GKS+++ L GQ +
Sbjct: 1051 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKL 1110
Query: 535 GVVAVNGTLAYVSQQAWIFHGNVRENILFGEK---YDHQRYQHTVRVCGLQKDLSNLPYG 591
V + L VSQ+ +F ++ ENI +G+ + + + LP+
Sbjct: 1111 NVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHK 1170
Query: 592 DLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLR 651
T +G++G LSGGQ+QRI++ARA+ Q+ LLD+ SA+D K V +E + K
Sbjct: 1171 YETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKARE 1229
Query: 652 GKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQ 706
G+T +++ H+L +++ D +++ ++G + E GTH++L+ ++G Y ++ G Q
Sbjct: 1230 GRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1284
Score = 113 bits (283), Expect = 1e-24
Identities = 117/512 (22%), Positives = 209/512 (40%), Gaps = 63/512 (12%)
Query: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
+L ++ V+ G+ + + G+ G GKS+ + + +G + ++G
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
Query: 543 -LAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
+ VSQ+ +F + ENI +G + V+ + + LP T +GERG
Sbjct: 471 IIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERG 530
Query: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
LSGGQ+QRI++ARA+ + ++ LLD+ SA+D V + + K G+T +++ H
Sbjct: 531 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAH 589
Query: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIH-NLRGLQFKDPEHLYNAAMV 719
+L + + D + EDG I E+G+H ELM++ G Y KL++ G Q + E N
Sbjct: 590 RLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELN---- 645
Query: 720 EAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTW 779
E A R +AP K T ++++ + L E V
Sbjct: 646 ---DEKAATR--------MAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPP 694
Query: 780 KTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEV 839
++ +K + T + + ++ A +N L P + E+
Sbjct: 695 VSFLKVLKLNK-------TEWPYFVVGTVCAIANGGL------------QPAFSVIFSEI 735
Query: 840 GAVLADIGQHVYQWVYTASMVFMLVFGV-------TKGFVFTKTTLMASSSLHDTVFDKI 892
A+ V Q + L G+ +GF F K + + L F +
Sbjct: 736 IAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAM 795
Query: 893 LKSPMSFFD--TTPTGRLMNRFSKDMDELD----VRLPFHAENFLQQFFMVVFILVILAA 946
L+ MS+FD TG L R + D ++ RL A+N ++ +
Sbjct: 796 LRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQ 855
Query: 947 VFPAVLLVVASLAVGFFILLRIFHRGVQELKK 978
+ +L VV +AV + +++ + KK
Sbjct: 856 LTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKK 887
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 149 bits (375), Expect = 2e-35
Identities = 88/238 (36%), Positives = 137/238 (57%), Gaps = 2/238 (0%)
Query: 1117 RGEITFRDYQMRYRDNTPL-VLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPAS 1175
+G + F D Y + +L LNL +QSGQTV +VG +G GKS+ + RL +P
Sbjct: 391 KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE 450
Query: 1176 GTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESH-TDEMLWQVLERTF 1234
GTI ID DI ++ LR + V+ Q+PVLF T+ N+ + T + + + ++
Sbjct: 451 GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEAN 510
Query: 1235 MRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTL 1294
+ IMKLP+K V E G S G++Q + +ARAL+RN KI+LLDEAT+++D++++
Sbjct: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
Query: 1295 VQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAML 1352
VQ + A +G T + IAHRL+TV N D + E+G ++E L +K F ++
Sbjct: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
Score = 141 bits (356), Expect = 4e-33
Identities = 80/240 (33%), Positives = 140/240 (58%), Gaps = 6/240 (2%)
Query: 1118 GEITFRDYQMRY--RDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPAS 1175
G ITF + Y R N P VL L+L ++ GQT+ +VG +G GKS++ L R +P +
Sbjct: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
Query: 1176 GTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNL---DPFESHTDEMLWQVLER 1232
GT+ +D + L+++ LR +L ++ Q+P+LF ++ N+ D + + + +
Sbjct: 1091 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1150
Query: 1233 TFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTD 1292
+ I LP K + V + G S G++Q + +ARAL+R +I+LLDEAT+++D++++
Sbjct: 1151 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1210
Query: 1293 TLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAML 1352
+VQ + A +G T + IAHRL+T+ N D ++V +NG+V E + L + F+M+
Sbjct: 1211 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1270
Score = 118 bits (295), Expect = 4e-26
Identities = 67/228 (29%), Positives = 120/228 (52%), Gaps = 17/228 (7%)
Query: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
VL +S V+KG+ L + G+ G GKS+++ L G V ++G
Sbjct: 1051 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRA 1110
Query: 543 -LAYVSQQAWIFHGNVRENILFGEK---YDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
L VSQ+ +F ++ ENI +G+ + + + LP+ T +G+
Sbjct: 1111 QLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGD 1170
Query: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
+G LSGGQ+QRI++ARA+ Q+ LLD+ SA+D K V +E + K G+T +++
Sbjct: 1171 KGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIVI 1229
Query: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQ 706
H+L +++ D +++ ++G + E GTH++L+ ++G Y ++ G Q
Sbjct: 1230 AHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1277
Score = 113 bits (283), Expect = 1e-24
Identities = 117/512 (22%), Positives = 209/512 (40%), Gaps = 63/512 (12%)
Query: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
+L ++ V+ G+ + + G+ G GKS+ + + +G + ++G
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
Query: 543 -LAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
+ VSQ+ +F + ENI +G + V+ + + LP T +GERG
Sbjct: 471 IIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERG 530
Query: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
LSGGQ+QRI++ARA+ + ++ LLD+ SA+D V + + K G+T +++ H
Sbjct: 531 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAH 589
Query: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIH-NLRGLQFKDPEHLYNAAMV 719
+L + + D + EDG I E+G+H ELM++ G Y KL++ G Q + E N
Sbjct: 590 RLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELN---- 645
Query: 720 EAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTW 779
E A R +AP K T ++++ + L E V
Sbjct: 646 ---DEKAATR--------MAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPP 694
Query: 780 KTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEV 839
++ +K + T + + ++ A +N L P + E+
Sbjct: 695 VSFLKVLKLNK-------TEWPYFVVGTVCAIANGGL------------QPAFSVIFSEI 735
Query: 840 GAVLADIGQHVYQWVYTASMVFMLVFGV-------TKGFVFTKTTLMASSSLHDTVFDKI 892
A+ V Q + L G+ +GF F K + + L F +
Sbjct: 736 IAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAM 795
Query: 893 LKSPMSFFD--TTPTGRLMNRFSKDMDELD----VRLPFHAENFLQQFFMVVFILVILAA 946
L+ MS+FD TG L R + D ++ RL A+N ++ +
Sbjct: 796 LRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQ 855
Query: 947 VFPAVLLVVASLAVGFFILLRIFHRGVQELKK 978
+ +L VV +AV + +++ + KK
Sbjct: 856 LTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKK 887
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 148 bits (373), Expect = 4e-35
Identities = 127/521 (24%), Positives = 238/521 (45%), Gaps = 34/521 (6%)
Query: 855 YTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSK 914
Y V +L+ G + + + F +I++ + +FD G L RFS
Sbjct: 145 YAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSD 204
Query: 915 DMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQ 974
D+++++ + F+Q+ M I L F L + ++V I + G+
Sbjct: 205 DINKINDAIADQMALFIQR--MTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLS 262
Query: 975 ELKKVENVSRSPWFTHITSS--MQGLGIIHAYGKKESCITYHLLYFNCALRWFALRMDVL 1032
K + ++ + + + + + A+G ++ + + A RW +R ++
Sbjct: 263 VSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRW-GIRKGIV 321
Query: 1033 MNILTFTVALLVTLSFSSISTSSKGLSLS------------YIIQLSGLLQV-----CVR 1075
M T V L+ L ++ L L ++ + G L + C+
Sbjct: 322 MGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLE 381
Query: 1076 TGTETQAKFTSV--ELLREYISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNT 1133
+A TS+ + R+ I C+ E + L +GEI F + Y
Sbjct: 382 AFATGRAAATSIFETIDRKPIIDCMSEDGYKLD--------RIKGEIEFHNVTFHYPSRP 433
Query: 1134 PL-VLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLED 1192
+ +L+ LN+ I+ G+ +VG +G+GKS+ + R +P G + +D DI L+++
Sbjct: 434 EVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQW 493
Query: 1193 LRTKLTVIPQDPVLFVGTVRYNLD-PFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVT 1251
LR ++ ++ Q+PVLF T+ N+ E T E + Q + + IM LP++ V
Sbjct: 494 LRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVG 553
Query: 1252 ENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTI 1311
E G S G++Q + +ARAL+RN KI+LLD AT+++D++++ +VQ + G T++++
Sbjct: 554 EGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISV 613
Query: 1312 AHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAML 1352
AHRL+TV D ++ E+G +E E L E+ F ++
Sbjct: 614 AHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLV 654
Score = 139 bits (349), Expect = 2e-32
Identities = 85/248 (34%), Positives = 146/248 (58%), Gaps = 7/248 (2%)
Query: 1104 PLKV-GTCPKDWPS-RGEITFRDYQMRYRDNTPL-VLDSLNLNIQSGQTVGIVGRTGSGK 1160
P+ V T + W + +G+I F D + Y VL+ L+++I GQT+ VG +G GK
Sbjct: 1060 PISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGK 1119
Query: 1161 SSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFES 1220
S+ L R +P G + ID D ++++ LR+ + ++ Q+PVLF ++ N+ ++
Sbjct: 1120 STSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDN 1179
Query: 1221 HTDEMLWQVL---ERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKI 1277
+ + +V+ ++ + D +M LPEK + V G S GE+Q + +ARA++R+ KI
Sbjct: 1180 TKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKI 1239
Query: 1278 ILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIE-FD 1336
+LLDEAT+++D++++ VQ + A +G T + IAHRL+T+ N D + VM G VIE
Sbjct: 1240 LLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGT 1299
Query: 1337 KPEVLAEK 1344
E++A+K
Sbjct: 1300 HEELMAQK 1307
Score = 107 bits (268), Expect = 6e-23
Identities = 65/221 (29%), Positives = 116/221 (52%), Gaps = 17/221 (7%)
Query: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG------------- 541
VL+ +S + G+ L G+ G GKS+ + L +G V ++G
Sbjct: 1095 VLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRS 1154
Query: 542 TLAYVSQQAWIFHGNVRENILFGEKYDH---QRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
+ VSQ+ +F ++ +NI +G+ +R + L + +LP T +G
Sbjct: 1155 NIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGS 1214
Query: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
+G LS G++QRI++ARA+ D ++ LLD+ SA+D K V + + K G+T +++
Sbjct: 1215 QGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV-QVALDKAREGRTCIVI 1273
Query: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLI 699
H+L +++ D + ++ G + EKGTH+ELM ++G Y KL+
Sbjct: 1274 AHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
Score = 102 bits (253), Expect = 3e-21
Identities = 63/219 (28%), Positives = 114/219 (52%), Gaps = 15/219 (6%)
Query: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG------------- 541
+L+ ++ V++ G++ + G G+GKS+ L + +G+V V+G
Sbjct: 437 ILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRD 496
Query: 542 TLAYVSQQAWIFHGNVRENILFG-EKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
+ V Q+ +F + ENI +G E + + + +LP T +GE G
Sbjct: 497 QIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGG 556
Query: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
+SGGQ+QR+++ARA+ + ++ LLD SA+D + + + +E + K G T++ V H
Sbjct: 557 GQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSKIQHGHTIISVAH 615
Query: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLI 699
+L + + D +I E G E+GTH+EL+E +G Y L+
Sbjct: 616 RLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLV 654
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,317,472
Number of Sequences: 37866
Number of extensions: 2023797
Number of successful extensions: 6472
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 5795
Number of HSP's gapped (non-prelim): 329
length of query: 1359
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1244
effective length of database: 13,892,928
effective search space: 17282802432
effective search space used: 17282802432
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.