Guide to the Human Genome
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Search of human proteins with 88758613

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|88758613 CD93 antigen precursor [Homo sapiens]
         (652 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|88758613 CD93 antigen precursor [Homo sapiens]                    1386   0.0  
gi|9966885 tumor endothelial marker 1 precursor [Homo sapiens]        201   2e-51
gi|4507483 thrombomodulin precursor [Homo sapiens]                    198   1e-50
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]              151   2e-36
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]              151   2e-36
gi|34734066 fibulin 1 isoform D [Homo sapiens]                        151   2e-36
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]              151   2e-36
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               146   5e-35
gi|24430141 fibrillin 1 precursor [Homo sapiens]                      143   4e-34
gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens]   142   7e-34
gi|46249414 latent transforming growth factor beta binding prote...   140   3e-33
gi|46249412 latent transforming growth factor beta binding prote...   140   3e-33
gi|66346695 fibrillin 2 precursor [Homo sapiens]                      138   2e-32
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]     138   2e-32
gi|194328809 latent transforming growth factor beta binding prot...   137   3e-32
gi|18497288 latent transforming growth factor beta binding prote...   137   3e-32
gi|110347437 latent transforming growth factor beta binding prot...   137   4e-32
gi|110347412 latent transforming growth factor beta binding prot...   137   4e-32
gi|110347431 latent transforming growth factor beta binding prot...   137   4e-32
gi|19743803 fibulin 5 precursor [Homo sapiens]                        134   3e-31
gi|56237021 fibrillin 3 precursor [Homo sapiens]                      130   4e-30
gi|190343004 EGF-containing fibulin-like extracellular matrix pr...   130   5e-30
gi|10190748 CEGP1 protein [Homo sapiens]                              128   1e-29
gi|4557733 latent transforming growth factor beta binding protei...   128   2e-29
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]              127   3e-29
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]              127   3e-29
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]    126   7e-29
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]             125   1e-28
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]             125   1e-28
gi|118572606 hemicentin 1 [Homo sapiens]                              124   3e-28

>gi|88758613 CD93 antigen precursor [Homo sapiens]
          Length = 652

 Score = 1386 bits (3588), Expect = 0.0
 Identities = 652/652 (100%), Positives = 652/652 (100%)

Query: 1   MATSMGLLLLLLLLLTQPGAGTGADTEAVVCVGTACYTAHSGKLSAAEAQNHCNQNGGNL 60
           MATSMGLLLLLLLLLTQPGAGTGADTEAVVCVGTACYTAHSGKLSAAEAQNHCNQNGGNL
Sbjct: 1   MATSMGLLLLLLLLLTQPGAGTGADTEAVVCVGTACYTAHSGKLSAAEAQNHCNQNGGNL 60

Query: 61  ATVKSKEEAQHVQRVLAQLLRREAALTARMSKFWIGLQREKGKCLDPSLPLKGFSWVGGG 120
           ATVKSKEEAQHVQRVLAQLLRREAALTARMSKFWIGLQREKGKCLDPSLPLKGFSWVGGG
Sbjct: 61  ATVKSKEEAQHVQRVLAQLLRREAALTARMSKFWIGLQREKGKCLDPSLPLKGFSWVGGG 120

Query: 121 EDTPYSNWHKELRNSCISKRCVSLLLDLSQPLLPSRLPKWSEGPCGSPGSPGSNIEGFVC 180
           EDTPYSNWHKELRNSCISKRCVSLLLDLSQPLLPSRLPKWSEGPCGSPGSPGSNIEGFVC
Sbjct: 121 EDTPYSNWHKELRNSCISKRCVSLLLDLSQPLLPSRLPKWSEGPCGSPGSPGSNIEGFVC 180

Query: 181 KFSFKGMCRPLALGGPGQVTYTTPFQTTSSSLEAVPFASAANVACGEGDKDETQSHYFLC 240
           KFSFKGMCRPLALGGPGQVTYTTPFQTTSSSLEAVPFASAANVACGEGDKDETQSHYFLC
Sbjct: 181 KFSFKGMCRPLALGGPGQVTYTTPFQTTSSSLEAVPFASAANVACGEGDKDETQSHYFLC 240

Query: 241 KEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTC 300
           KEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTC
Sbjct: 241 KEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTC 300

Query: 301 ASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVN 360
           ASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVN
Sbjct: 301 ASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVN 360

Query: 361 TPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGE 420
           TPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGE
Sbjct: 361 TPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGE 420

Query: 421 DGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGP 480
           DGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGP
Sbjct: 421 DGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGP 480

Query: 481 PDEEDKGEKEGSTVPRAATASPTRGPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGS 540
           PDEEDKGEKEGSTVPRAATASPTRGPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGS
Sbjct: 481 PDEEDKGEKEGSTVPRAATASPTRGPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGS 540

Query: 541 PGVWREPSIHHATAASGPQEPAGGDSSVATQNNDGTDGQKLLLFYILGTVVAILLLLALA 600
           PGVWREPSIHHATAASGPQEPAGGDSSVATQNNDGTDGQKLLLFYILGTVVAILLLLALA
Sbjct: 541 PGVWREPSIHHATAASGPQEPAGGDSSVATQNNDGTDGQKLLLFYILGTVVAILLLLALA 600

Query: 601 LGLLVYRKRRAKREEKKEKKPQNAADSYSWVPERAESRAMENQYSPTPGTDC 652
           LGLLVYRKRRAKREEKKEKKPQNAADSYSWVPERAESRAMENQYSPTPGTDC
Sbjct: 601 LGLLVYRKRRAKREEKKEKKPQNAADSYSWVPERAESRAMENQYSPTPGTDC 652


>gi|9966885 tumor endothelial marker 1 precursor [Homo sapiens]
          Length = 757

 Score =  201 bits (510), Expect = 2e-51
 Identities = 137/401 (34%), Positives = 189/401 (47%), Gaps = 54/401 (13%)

Query: 7   LLLLLLLLLTQPGAGTGADTEAV----VCVGTACYTAHSGKLSAAEAQNHCNQNGGNLAT 62
           +LL LLL     G   G D  A      C  ++CY     + +  EA   C + GG+LAT
Sbjct: 1   MLLRLLLAWAAAGPTLGQDPWAAEPRAACGPSSCYALFPRRRTFLEAWRACRELGGDLAT 60

Query: 63  VKSKEEAQHVQRVLAQLLRREAALTARMSKFWIGLQREKGKCLDPSLPLKGFSWVGGGED 122
            ++ EEAQ V  ++       A   +R+   WIGLQR+  +C     PL+GF+W  G +D
Sbjct: 61  PRTPEEAQRVDSLVG------AGPASRL--LWIGLQRQARQC-QLQRPLRGFTWTTGDQD 111

Query: 123 TPYSNWHKELRNS-CISKRCVSLLLDLSQPLLPSRLPKWSEGPCGSPGSPGSNIEGFVCK 181
           T ++NW +      C ++RCV+L          S   +W EG C         ++G++C+
Sbjct: 112 TAFTNWAQPASGGPCPAQRCVALEA--------SGEHRWLEGSCTLA------VDGYLCQ 157

Query: 182 FSFKGMCRPLA--LGGPGQVTYTTPFQTTSSSLEAVPFASAANVACGEGDKDETQSHYFL 239
           F F+G C  L    G  G   YTTPF   S+  E +PF S A V C  G     +    L
Sbjct: 158 FGFEGACPALQDEAGQAGPAVYTTPFHLVSTEFEWLPFGSVAAVQCQAG-----RGASLL 212

Query: 240 CKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVT 299
           C ++      W  +GPLC+    GC+ +NGGC  +C E  DG   C C  GFRL  D  +
Sbjct: 213 CVKQPEGGVGWSRAGPLCLGT--GCSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRS 270

Query: 300 CASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQ-LDSSQLDCVDVDECQ-DSPCAQE 357
           C   +PC+ +PC        GP G  Y+C C  G++  +     CVD DECQ    C Q 
Sbjct: 271 C--EDPCAQAPCEQQCE-PGGPQG--YSCHCRLGFRPAEDDPHRCVDTDECQIAGVCQQM 325

Query: 358 CVNTPGGFRCECWVGYE----------PGGPGEGACQDVDE 388
           CVN  GGF C C  G+E           G  G  A QD+ +
Sbjct: 326 CVNYVGGFECYCSEGHELEADGISCSPAGAMGAQASQDLGD 366


>gi|4507483 thrombomodulin precursor [Homo sapiens]
          Length = 575

 Score =  198 bits (503), Expect = 1e-50
 Identities = 172/557 (30%), Positives = 233/557 (41%), Gaps = 103/557 (18%)

Query: 5   MGLLLLLLLLLTQPGAGTGADTE--AVVCVGTACYTAHSGKLSAAEAQNHCNQNGGNLAT 62
           +G+L+L  L L   G    A+ +     CV   C+  + G  +   A   C+   G+L T
Sbjct: 2   LGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMT 61

Query: 63  VKSKEEAQHVQRVLAQLLRREAALTARMSKFWIGLQREKGKCLDPSL--PLKGFSWVGGG 120
           V+S   A     V++ LL  +  +  R  + WIGLQ   G C DP    PL+GF WV G 
Sbjct: 62  VRSSVAAD----VISLLLNGDGGVGRR--RLWIGLQLPPG-CGDPKRLGPLRGFQWVTGD 114

Query: 121 EDTPYSNWHKELRNSCISKRCVSLLLDLSQPLLPSRLPKWSEGPCGSPGSPGSNIEGFVC 180
            +T YS W +   N       + + +  ++  +PS  P W E  C          +GF+C
Sbjct: 115 NNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSE-PIWEEQQCEVKA------DGFLC 167

Query: 181 KFSFKGMCRPLALGGPG------QVTYTTPFQTTSSSLEAVPFASAANVA-------CGE 227
           +F F   CRPLA+  PG       +TY TPF    +  +A+P  S+A VA       C  
Sbjct: 168 EFHFPATCRPLAVE-PGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMC-T 225

Query: 228 GDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGC 287
                 Q H+     +AP  +D              C+  NGGC   C     G+  C C
Sbjct: 226 APPGAVQGHW---AREAPGAWD--------------CSVENGGCEHAC-NAIPGAPRCQC 267

Query: 288 RPGFRLLDDLVTC-ASRNPCSSSPCRGGATCVLGPHGK-NYTCRCPQGYQLDSSQLDCVD 345
             G  L  D  +C AS     +  C     CV  P    +Y+C C  GY+L + Q  C D
Sbjct: 268 PAGAALQADGRSCTASATQSCNDLCEH--FCVPNPDQPGSYSCMCETGYRLAADQHRCED 325

Query: 346 VDEC--QDSPCAQECVNTPGGFRCECWVGY--------EPGGP-----GEGACQDVDE-- 388
           VD+C  + SPC Q CVNT GGF C C+  Y        EP  P      E  CQ +++  
Sbjct: 326 VDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTS 385

Query: 389 ----CALGRSP-------CAQGCTNT--------DGSFHCSCEEGYVLAGEDGTQCQDVD 429
               CA G +P       C   C  T        +    C C EGY+L  +DG  C D+D
Sbjct: 386 YLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYIL--DDGFICTDID 443

Query: 430 ECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPN-GVSCTMGPVSLGPPSGPPDEEDKGE 488
           EC    G  C  +C N  G+F C C P   LA + G  C  G V  G       +   GE
Sbjct: 444 EC--ENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGG-------DSGSGE 494

Query: 489 KEGSTVPRAATASPTRG 505
              S  P +    P  G
Sbjct: 495 PPPSPTPGSTLTPPAVG 511


>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
          Length = 601

 Score =  151 bits (382), Expect = 2e-36
 Identities = 79/200 (39%), Positives = 106/200 (53%), Gaps = 17/200 (8%)

Query: 280 DGSFLC-----GCRPGFRLLDDLVTCASRNPCS--SSPCRGGATCVLGPHGKNYTCRCPQ 332
           +GS+ C      C  G+ L ++   C   + C+  + PC  G  CV  P   ++ C C  
Sbjct: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG--SFRCECKT 386

Query: 333 GYQLDSSQLDCVDVDECQDSP---CAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDEC 389
           GY  D     CVDV+ECQ  P   C  +C NT G + C C VG+     G  +C+D++EC
Sbjct: 387 GYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGR-SCEDINEC 445

Query: 390 ALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGP-GGPLCDSLCFNTQG 448
           +   SPC+Q C N  GS+ C C  GY L+  DG  C+D+DEC  P GG +C   C N  G
Sbjct: 446 S--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPG 503

Query: 449 SFHCGC-LPGWVLAPNGVSC 467
           SF C C   G+ LAPNG +C
Sbjct: 504 SFQCSCPSSGYRLAPNGRNC 523



 Score =  128 bits (322), Expect = 1e-29
 Identities = 73/179 (40%), Positives = 90/179 (50%), Gaps = 12/179 (6%)

Query: 281 GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCR-GGATC--VLGPHGKNYTCRCPQGYQLD 337
           GSF C C+ G+        C   N C   P R  G  C   LG    +Y C C  G++L 
Sbjct: 378 GSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG----SYLCSCSVGFRLS 433

Query: 338 SSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECAL--GRSP 395
                C D++EC  SPC+QEC N  G ++C C  GY+        C+D+DECAL  G   
Sbjct: 434 VDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHI 493

Query: 396 CAQGCTNTDGSFHCSC-EEGYVLAGEDGTQCQDVDECV-GPGGPLCDSLCFNTQGSFHC 452
           C+  C N  GSF CSC   GY LA  +G  CQD+DECV G      +  CFN QG F C
Sbjct: 494 CSYRCINIPGSFQCSCPSSGYRLA-PNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  119 bits (297), Expect = 1e-26
 Identities = 79/211 (37%), Positives = 103/211 (48%), Gaps = 27/211 (12%)

Query: 269 GGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC--SSSPCRGGATCV--LGPHGK 324
           G C Q C + GD   +C C  G++LL D V+C   N C   S  CR G +C+  +G    
Sbjct: 184 GPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC 242

Query: 325 NYTCRCPQGYQLDSSQLDCVDVDECQDS--PCAQE--CVNTPGGFRC----ECWVGYEPG 376
                C  GY+L      C D+DEC+     C  +  C NT G FRC    +C  G+   
Sbjct: 243 QRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD 301

Query: 377 GPGEGACQDVDECALGRSPCAQG--CTNTDGSFHC-----SCEEGYVLAGEDGTQCQDVD 429
             G   C D++EC    +PC  G  C NT+GS+ C     +C  GY L  E+GT+C DVD
Sbjct: 302 ALGN--CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL-NEEGTRCVDVD 358

Query: 430 ECVGPGGPLCDS--LCFNTQGSFHCGCLPGW 458
           EC  P  P C     C N+ GSF C C  G+
Sbjct: 359 ECAPPAEP-CGKGHRCVNSPGSFRCECKTGY 388



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 66/200 (33%), Positives = 89/200 (44%), Gaps = 29/200 (14%)

Query: 304 NPCSSSPCRGGATCV--LGPHGKNYTCRCPQGYQLDSSQLDCVDVDEC----QDSPCAQE 357
           +P  +  CRGG  C       G    C C  GYQL S  + C DV+EC          + 
Sbjct: 173 DPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232

Query: 358 CVNTPGGFRCE----CWVGYEPGGPGEGACQDVDECALGRSPCAQG--CTNTDGSFHC-- 409
           C+NT G FRC+    C  GYE     + +C+D+DEC  G   C     C NT GSF C  
Sbjct: 233 CINTVGSFRCQRDSSCGTGYEL--TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290

Query: 410 --SCEEGYVLAGEDGT-QCQDVDECVGPGGPL-CDSLCFNTQGSFHC-----GCLPGWVL 460
              C+ G++   +D    C D++EC+    P      C NT+GS+ C      C  G+ L
Sbjct: 291 KLQCKSGFI---QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL 347

Query: 461 APNGVSCTMGPVSLGPPSGP 480
              G  C +      PP+ P
Sbjct: 348 NEEGTRC-VDVDECAPPAEP 366


>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
          Length = 566

 Score =  151 bits (382), Expect = 2e-36
 Identities = 79/200 (39%), Positives = 106/200 (53%), Gaps = 17/200 (8%)

Query: 280 DGSFLC-----GCRPGFRLLDDLVTCASRNPCS--SSPCRGGATCVLGPHGKNYTCRCPQ 332
           +GS+ C      C  G+ L ++   C   + C+  + PC  G  CV  P   ++ C C  
Sbjct: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG--SFRCECKT 386

Query: 333 GYQLDSSQLDCVDVDECQDSP---CAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDEC 389
           GY  D     CVDV+ECQ  P   C  +C NT G + C C VG+     G  +C+D++EC
Sbjct: 387 GYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGR-SCEDINEC 445

Query: 390 ALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGP-GGPLCDSLCFNTQG 448
           +   SPC+Q C N  GS+ C C  GY L+  DG  C+D+DEC  P GG +C   C N  G
Sbjct: 446 S--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPG 503

Query: 449 SFHCGC-LPGWVLAPNGVSC 467
           SF C C   G+ LAPNG +C
Sbjct: 504 SFQCSCPSSGYRLAPNGRNC 523



 Score =  128 bits (322), Expect = 1e-29
 Identities = 73/179 (40%), Positives = 90/179 (50%), Gaps = 12/179 (6%)

Query: 281 GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCR-GGATC--VLGPHGKNYTCRCPQGYQLD 337
           GSF C C+ G+        C   N C   P R  G  C   LG    +Y C C  G++L 
Sbjct: 378 GSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG----SYLCSCSVGFRLS 433

Query: 338 SSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECAL--GRSP 395
                C D++EC  SPC+QEC N  G ++C C  GY+        C+D+DECAL  G   
Sbjct: 434 VDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHI 493

Query: 396 CAQGCTNTDGSFHCSC-EEGYVLAGEDGTQCQDVDECV-GPGGPLCDSLCFNTQGSFHC 452
           C+  C N  GSF CSC   GY LA  +G  CQD+DECV G      +  CFN QG F C
Sbjct: 494 CSYRCINIPGSFQCSCPSSGYRLA-PNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  119 bits (297), Expect = 1e-26
 Identities = 79/211 (37%), Positives = 103/211 (48%), Gaps = 27/211 (12%)

Query: 269 GGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC--SSSPCRGGATCV--LGPHGK 324
           G C Q C + GD   +C C  G++LL D V+C   N C   S  CR G +C+  +G    
Sbjct: 184 GPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC 242

Query: 325 NYTCRCPQGYQLDSSQLDCVDVDECQDS--PCAQE--CVNTPGGFRC----ECWVGYEPG 376
                C  GY+L      C D+DEC+     C  +  C NT G FRC    +C  G+   
Sbjct: 243 QRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD 301

Query: 377 GPGEGACQDVDECALGRSPCAQG--CTNTDGSFHC-----SCEEGYVLAGEDGTQCQDVD 429
             G   C D++EC    +PC  G  C NT+GS+ C     +C  GY L  E+GT+C DVD
Sbjct: 302 ALGN--CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL-NEEGTRCVDVD 358

Query: 430 ECVGPGGPLCDS--LCFNTQGSFHCGCLPGW 458
           EC  P  P C     C N+ GSF C C  G+
Sbjct: 359 ECAPPAEP-CGKGHRCVNSPGSFRCECKTGY 388



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 66/200 (33%), Positives = 89/200 (44%), Gaps = 29/200 (14%)

Query: 304 NPCSSSPCRGGATCV--LGPHGKNYTCRCPQGYQLDSSQLDCVDVDEC----QDSPCAQE 357
           +P  +  CRGG  C       G    C C  GYQL S  + C DV+EC          + 
Sbjct: 173 DPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232

Query: 358 CVNTPGGFRCE----CWVGYEPGGPGEGACQDVDECALGRSPCAQG--CTNTDGSFHC-- 409
           C+NT G FRC+    C  GYE     + +C+D+DEC  G   C     C NT GSF C  
Sbjct: 233 CINTVGSFRCQRDSSCGTGYEL--TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290

Query: 410 --SCEEGYVLAGEDGT-QCQDVDECVGPGGPL-CDSLCFNTQGSFHC-----GCLPGWVL 460
              C+ G++   +D    C D++EC+    P      C NT+GS+ C      C  G+ L
Sbjct: 291 KLQCKSGFI---QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL 347

Query: 461 APNGVSCTMGPVSLGPPSGP 480
              G  C +      PP+ P
Sbjct: 348 NEEGTRC-VDVDECAPPAEP 366


>gi|34734066 fibulin 1 isoform D [Homo sapiens]
          Length = 703

 Score =  151 bits (382), Expect = 2e-36
 Identities = 79/200 (39%), Positives = 106/200 (53%), Gaps = 17/200 (8%)

Query: 280 DGSFLC-----GCRPGFRLLDDLVTCASRNPCS--SSPCRGGATCVLGPHGKNYTCRCPQ 332
           +GS+ C      C  G+ L ++   C   + C+  + PC  G  CV  P   ++ C C  
Sbjct: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG--SFRCECKT 386

Query: 333 GYQLDSSQLDCVDVDECQDSP---CAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDEC 389
           GY  D     CVDV+ECQ  P   C  +C NT G + C C VG+     G  +C+D++EC
Sbjct: 387 GYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGR-SCEDINEC 445

Query: 390 ALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGP-GGPLCDSLCFNTQG 448
           +   SPC+Q C N  GS+ C C  GY L+  DG  C+D+DEC  P GG +C   C N  G
Sbjct: 446 S--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPG 503

Query: 449 SFHCGC-LPGWVLAPNGVSC 467
           SF C C   G+ LAPNG +C
Sbjct: 504 SFQCSCPSSGYRLAPNGRNC 523



 Score =  128 bits (322), Expect = 1e-29
 Identities = 73/179 (40%), Positives = 90/179 (50%), Gaps = 12/179 (6%)

Query: 281 GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCR-GGATC--VLGPHGKNYTCRCPQGYQLD 337
           GSF C C+ G+        C   N C   P R  G  C   LG    +Y C C  G++L 
Sbjct: 378 GSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG----SYLCSCSVGFRLS 433

Query: 338 SSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECAL--GRSP 395
                C D++EC  SPC+QEC N  G ++C C  GY+        C+D+DECAL  G   
Sbjct: 434 VDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHI 493

Query: 396 CAQGCTNTDGSFHCSC-EEGYVLAGEDGTQCQDVDECV-GPGGPLCDSLCFNTQGSFHC 452
           C+  C N  GSF CSC   GY LA  +G  CQD+DECV G      +  CFN QG F C
Sbjct: 494 CSYRCINIPGSFQCSCPSSGYRLA-PNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  119 bits (297), Expect = 1e-26
 Identities = 79/211 (37%), Positives = 103/211 (48%), Gaps = 27/211 (12%)

Query: 269 GGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC--SSSPCRGGATCV--LGPHGK 324
           G C Q C + GD   +C C  G++LL D V+C   N C   S  CR G +C+  +G    
Sbjct: 184 GPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC 242

Query: 325 NYTCRCPQGYQLDSSQLDCVDVDECQDS--PCAQE--CVNTPGGFRC----ECWVGYEPG 376
                C  GY+L      C D+DEC+     C  +  C NT G FRC    +C  G+   
Sbjct: 243 QRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD 301

Query: 377 GPGEGACQDVDECALGRSPCAQG--CTNTDGSFHC-----SCEEGYVLAGEDGTQCQDVD 429
             G   C D++EC    +PC  G  C NT+GS+ C     +C  GY L  E+GT+C DVD
Sbjct: 302 ALGN--CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL-NEEGTRCVDVD 358

Query: 430 ECVGPGGPLCDS--LCFNTQGSFHCGCLPGW 458
           EC  P  P C     C N+ GSF C C  G+
Sbjct: 359 ECAPPAEP-CGKGHRCVNSPGSFRCECKTGY 388



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 66/200 (33%), Positives = 89/200 (44%), Gaps = 29/200 (14%)

Query: 304 NPCSSSPCRGGATCV--LGPHGKNYTCRCPQGYQLDSSQLDCVDVDEC----QDSPCAQE 357
           +P  +  CRGG  C       G    C C  GYQL S  + C DV+EC          + 
Sbjct: 173 DPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232

Query: 358 CVNTPGGFRCE----CWVGYEPGGPGEGACQDVDECALGRSPCAQG--CTNTDGSFHC-- 409
           C+NT G FRC+    C  GYE     + +C+D+DEC  G   C     C NT GSF C  
Sbjct: 233 CINTVGSFRCQRDSSCGTGYEL--TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290

Query: 410 --SCEEGYVLAGEDGT-QCQDVDECVGPGGPL-CDSLCFNTQGSFHC-----GCLPGWVL 460
              C+ G++   +D    C D++EC+    P      C NT+GS+ C      C  G+ L
Sbjct: 291 KLQCKSGFI---QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL 347

Query: 461 APNGVSCTMGPVSLGPPSGP 480
              G  C +      PP+ P
Sbjct: 348 NEEGTRC-VDVDECAPPAEP 366


>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
          Length = 683

 Score =  151 bits (382), Expect = 2e-36
 Identities = 79/200 (39%), Positives = 106/200 (53%), Gaps = 17/200 (8%)

Query: 280 DGSFLC-----GCRPGFRLLDDLVTCASRNPCS--SSPCRGGATCVLGPHGKNYTCRCPQ 332
           +GS+ C      C  G+ L ++   C   + C+  + PC  G  CV  P   ++ C C  
Sbjct: 329 EGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPG--SFRCECKT 386

Query: 333 GYQLDSSQLDCVDVDECQDSP---CAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDEC 389
           GY  D     CVDV+ECQ  P   C  +C NT G + C C VG+     G  +C+D++EC
Sbjct: 387 GYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGR-SCEDINEC 445

Query: 390 ALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGP-GGPLCDSLCFNTQG 448
           +   SPC+Q C N  GS+ C C  GY L+  DG  C+D+DEC  P GG +C   C N  G
Sbjct: 446 S--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPG 503

Query: 449 SFHCGC-LPGWVLAPNGVSC 467
           SF C C   G+ LAPNG +C
Sbjct: 504 SFQCSCPSSGYRLAPNGRNC 523



 Score =  128 bits (322), Expect = 1e-29
 Identities = 73/179 (40%), Positives = 90/179 (50%), Gaps = 12/179 (6%)

Query: 281 GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCR-GGATC--VLGPHGKNYTCRCPQGYQLD 337
           GSF C C+ G+        C   N C   P R  G  C   LG    +Y C C  G++L 
Sbjct: 378 GSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG----SYLCSCSVGFRLS 433

Query: 338 SSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECAL--GRSP 395
                C D++EC  SPC+QEC N  G ++C C  GY+        C+D+DECAL  G   
Sbjct: 434 VDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHI 493

Query: 396 CAQGCTNTDGSFHCSC-EEGYVLAGEDGTQCQDVDECV-GPGGPLCDSLCFNTQGSFHC 452
           C+  C N  GSF CSC   GY LA  +G  CQD+DECV G      +  CFN QG F C
Sbjct: 494 CSYRCINIPGSFQCSCPSSGYRLA-PNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  119 bits (297), Expect = 1e-26
 Identities = 79/211 (37%), Positives = 103/211 (48%), Gaps = 27/211 (12%)

Query: 269 GGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC--SSSPCRGGATCV--LGPHGK 324
           G C Q C + GD   +C C  G++LL D V+C   N C   S  CR G +C+  +G    
Sbjct: 184 GPCKQQCRDTGD-EVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC 242

Query: 325 NYTCRCPQGYQLDSSQLDCVDVDECQDS--PCAQE--CVNTPGGFRC----ECWVGYEPG 376
                C  GY+L      C D+DEC+     C  +  C NT G FRC    +C  G+   
Sbjct: 243 QRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD 301

Query: 377 GPGEGACQDVDECALGRSPCAQG--CTNTDGSFHC-----SCEEGYVLAGEDGTQCQDVD 429
             G   C D++EC    +PC  G  C NT+GS+ C     +C  GY L  E+GT+C DVD
Sbjct: 302 ALGN--CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL-NEEGTRCVDVD 358

Query: 430 ECVGPGGPLCDS--LCFNTQGSFHCGCLPGW 458
           EC  P  P C     C N+ GSF C C  G+
Sbjct: 359 ECAPPAEP-CGKGHRCVNSPGSFRCECKTGY 388



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 66/200 (33%), Positives = 89/200 (44%), Gaps = 29/200 (14%)

Query: 304 NPCSSSPCRGGATCV--LGPHGKNYTCRCPQGYQLDSSQLDCVDVDEC----QDSPCAQE 357
           +P  +  CRGG  C       G    C C  GYQL S  + C DV+EC          + 
Sbjct: 173 DPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232

Query: 358 CVNTPGGFRCE----CWVGYEPGGPGEGACQDVDECALGRSPCAQG--CTNTDGSFHC-- 409
           C+NT G FRC+    C  GYE     + +C+D+DEC  G   C     C NT GSF C  
Sbjct: 233 CINTVGSFRCQRDSSCGTGYEL--TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290

Query: 410 --SCEEGYVLAGEDGT-QCQDVDECVGPGGPL-CDSLCFNTQGSFHC-----GCLPGWVL 460
              C+ G++   +D    C D++EC+    P      C NT+GS+ C      C  G+ L
Sbjct: 291 KLQCKSGFI---QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL 347

Query: 461 APNGVSCTMGPVSLGPPSGP 480
              G  C +      PP+ P
Sbjct: 348 NEEGTRC-VDVDECAPPAEP 366


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  146 bits (369), Expect = 5e-35
 Identities = 92/267 (34%), Positives = 113/267 (42%), Gaps = 58/267 (21%)

Query: 251 GSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP 310
           G  GP C      C  +NGGC   C     GS+LC C+PGFRL  D  TC + N C+   
Sbjct: 152 GFQGPRCQYDVDECRTHNGGCQHRCVNT-PGSYLCECKPGFRLHTDSRTCLAINSCALG- 209

Query: 311 CRGGAT--CVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDEC--QDSPCAQECVNTPGGFR 366
             GG    CV     + + C+C  G+QL      CV    C  ++  C   C    G  R
Sbjct: 210 -NGGCQHHCVQLTITR-HRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLAR 267

Query: 367 CECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQ 426
           CEC VGY+    G+ AC+DVDECA G + CA GC NT GSF C C  GY L G DG QC 
Sbjct: 268 CECHVGYQLAADGK-ACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYEL-GADGRQCY 325

Query: 427 ----------------------------------------------DVDECVGPGGPLCD 440
                                                         DVD+C     P C 
Sbjct: 326 RIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCAD--SPCCQ 383

Query: 441 SLCFNTQGSFHCGCLPGWVLAPNGVSC 467
            +C N  G + CGC  G+ L+ +G  C
Sbjct: 384 QVCTNNPGGYECGCYAGYRLSADGCGC 410



 Score =  133 bits (334), Expect = 6e-31
 Identities = 86/255 (33%), Positives = 105/255 (41%), Gaps = 58/255 (22%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSS--SPCRGGATCVLGP 321
           C   NGGC   C +       C CRPGF+L +D   C  R+PC++    C      V G 
Sbjct: 206 CALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGL 265

Query: 322 HGKNYTCRCPQGYQLDSSQLDCVDVDECQD--SPCAQECVNTPGGFRCECWVGYEPGGPG 379
                 C C  GYQL +    C DVDEC    + CA  C+NT G F+C C  GYE G  G
Sbjct: 266 A----RCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADG 321

Query: 380 ---------------------------------------------EGACQDVDECALGRS 394
                                                        +  C DVD+CA   S
Sbjct: 322 RQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCA--DS 379

Query: 395 PCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCG 453
           PC Q  CTN  G + C C  GY L+  DG  C+DVDEC    G  C+  C N  GSF C 
Sbjct: 380 PCCQQVCTNNPGGYECGCYAGYRLSA-DGCGCEDVDECASSRGG-CEHHCTNLAGSFQCS 437

Query: 454 CLPGWVLAPNGVSCT 468
           C  G+ L  +   C+
Sbjct: 438 CEAGYRLHEDRRGCS 452



 Score =  131 bits (329), Expect = 2e-30
 Identities = 73/171 (42%), Positives = 90/171 (52%), Gaps = 21/171 (12%)

Query: 271 CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASR-----NPCSSSPCRGGATCVLGPHGKN 325
           C   C     GSF C C  G+ L  D   C        N C ++   GG +     HG +
Sbjct: 296 CAHGCLNT-QGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEAN--NGGCS-----HGCS 347

Query: 326 YT-----CRCPQGYQLDSSQLDCVDVDECQDSPCAQE-CVNTPGGFRCECWVGYEPGGPG 379
           +T     C CP+GY+LD+ Q  C+DVD+C DSPC Q+ C N PGG+ C C+ GY     G
Sbjct: 348 HTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADG 407

Query: 380 EGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDE 430
            G C+DVDECA  R  C   CTN  GSF CSCE GY L  ED   C  ++E
Sbjct: 408 CG-CEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRL-HEDRRGCSPLEE 456



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 48/143 (33%), Positives = 64/143 (44%), Gaps = 13/143 (9%)

Query: 329 RCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFR-CECWVGYEPGGPGEGACQ-DV 386
           RC +G+     +  C+   EC  S C       PG  + C C  G++  GP    CQ DV
Sbjct: 109 RCCRGWMQQPDEEGCLSA-ECSASLCFHGGRCVPGSAQPCHCPPGFQ--GP---RCQYDV 162

Query: 387 DECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC-VGPGGPLCDSLCFN 445
           DEC      C   C NT GS+ C C+ G+ L   D   C  ++ C +G GG  C   C  
Sbjct: 163 DECRTHNGGCQHRCVNTPGSYLCECKPGFRL-HTDSRTCLAINSCALGNGG--CQHHCVQ 219

Query: 446 TQGSFH-CGCLPGWVLAPNGVSC 467
              + H C C PG+ L  +G  C
Sbjct: 220 LTITRHRCQCRPGFQLQEDGRHC 242



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 67/244 (27%), Positives = 82/244 (33%), Gaps = 25/244 (10%)

Query: 299  TCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQEC 358
            TC+ RN        G  +C LG  G++    CP G    +  L+C   +     P    C
Sbjct: 1304 TCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTC 1363

Query: 359  VNTPGGFRCECWVGYEPGGPGEGACQDVDECALGR--SPCAQGCTNTDGSFHCSCEEGYV 416
               PG +   C     PG  G G CQ +  C  G    P +  C    G     CE G  
Sbjct: 1364 RCGPGFYGQACEHPCPPGFHGAG-CQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERG-C 1421

Query: 417  LAGEDGTQCQDVDECVGPGGPLCD---SLCFNTQGSFHCGCLPGWVLAPNGVSCTM---- 469
              G  G  C    +C   GG  CD    LC    G     C         G SCT+    
Sbjct: 1422 EPGSFGEGCHQRCDC--DGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDC 1479

Query: 470  -GPVSLGPPSGPPDEEDKGEKEGSTVPRAATASPTRGPE------GTPKATPTTSRPSLS 522
             G     P SG     D     G   P      P R PE      G+    P +SRP+  
Sbjct: 1480 GGGADCDPVSGQCHCVD-----GYMGPTCREGGPLRLPENPSLAQGSAGTLPASSRPTSR 1534

Query: 523  SDAP 526
            S  P
Sbjct: 1535 SGGP 1538



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 60/222 (27%), Positives = 81/222 (36%), Gaps = 35/222 (15%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCG--CRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGP 321
           C     GC  DC EG  G  +C   C P     +   +C+ +N  +     G   C  G 
Sbjct: 533 CLLGLDGC--DCPEGWTG-LICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGV 589

Query: 322 HGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEG 381
            G N    CP+GY     +  C   +  +       C+  PG +   C +   P   G G
Sbjct: 590 SGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPG 649

Query: 382 ACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDE----------- 430
            C +  +C     P  Q C   DGS  CSC+ G+      G +CQ   E           
Sbjct: 650 -CSEECQCV---QPHTQSCDKRDGS--CSCKAGF-----RGERCQAECELGYFGPGCWQA 698

Query: 431 CVGPGGPLCDSLCFNTQGSFHCG--CLPGWVLAPNGVSCTMG 470
           C  P G  CDS+      S  CG  C  G+     G  C +G
Sbjct: 699 CTCPVGVACDSV------SGECGKRCPAGFQGEDCGQECPVG 734



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 65/248 (26%), Positives = 81/248 (32%), Gaps = 52/248 (20%)

Query: 240 CKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSF----LCGCRPGFRLLD 295
           C ++ P  F     G  C    +G N     C   C  GG         C C PG    D
Sbjct: 714 CGKRCPAGFQGEDCGQECPVGTFGVN-----CSSSCSCGGAPCHGVTGQCRCPPGRTGED 768

Query: 296 DLVTC--------------ASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQL 341
               C              A ++     P  G   C+ G  G      CP G+   S Q 
Sbjct: 769 CEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQT 828

Query: 342 DCVDVDECQDSPCAQECVNTPG--GFRCE--CWVGYEPGGPGEGACQDVDECALGRSPCA 397
            C   ++    P    C   PG  GF C+  C  G+   GP    C     C+ G   C 
Sbjct: 829 RCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGH--WGPD---CSHPCNCSAGHGSC- 882

Query: 398 QGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC-VGPGGPLCDSLCFNTQG------SF 450
                   S  C CE GYV     G +C+   +C  G  GP C+  C    G      S 
Sbjct: 883 -----DAISGLCLCEAGYV-----GPRCE--QQCPQGHFGPGCEQRCQCQHGAACDHVSG 930

Query: 451 HCGCLPGW 458
            C C  GW
Sbjct: 931 ACTCPAGW 938



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 57/209 (27%), Positives = 69/209 (33%), Gaps = 27/209 (12%)

Query: 266  FNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKN 325
            F   GC Q C     GSF   C         +  C   NP +  P  G  +C  G HG +
Sbjct: 1153 FTGSGCEQAC---PPGSFGEDCA-------QMCQCPGENP-ACHPATGTCSCAAGYHGPS 1201

Query: 326  YTCRCPQG-YQLDSSQL-DCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGAC 383
               RCP G Y     QL  C++   C  +  A  C     G  C         GP    C
Sbjct: 1202 CQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPN---C 1258

Query: 384  QDVDECALGRS--PCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS 441
              V  C  G +  P    C    G     CE G       G  C+    C   G      
Sbjct: 1259 THVCGCGQGAACDPVTGTCLCPPGRAGVRCERG-CPQNRFGVGCEHTCSCRNGG------ 1311

Query: 442  LCFNTQGSFHCGCLPGWVLAPNGVSCTMG 470
            LC  + GS  C C  GW      ++C  G
Sbjct: 1312 LCHASNGS--CSCGLGWTGRHCELACPPG 1338



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 61/227 (26%), Positives = 78/227 (34%), Gaps = 24/227 (10%)

Query: 240  CKEKAPDVFDWGSSGPLCVSP---KYG--CNFNNGGCHQDCFEGGDGSFL-CGCRPGFRL 293
            C+++ P     G  GP C      ++G  C+  +G C   C  G  G+F    C  GF  
Sbjct: 900  CEQQCPQ----GHFGPGCEQRCQCQHGAACDHVSGAC--TCPAGWRGTFCEHACPAGFFG 953

Query: 294  LDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSP 353
            LD    C      +     G   C  G  G      CP      +    C   +     P
Sbjct: 954  LDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDP 1013

Query: 354  CAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEE 413
               +C   PG     C      G  G+  C+    C      C  G T    S HC+C E
Sbjct: 1014 VHGQCHCAPGWMGPSCLQACPAGLYGDN-CR--HSCL-----CQNGGTCDPVSGHCACPE 1065

Query: 414  GYV-LAGEDGTQCQDVDE-CVGPGGPLCDSLCFNTQGSFHCGCLPGW 458
            G+  LA E     +DV   C   GG L   LC    G   C C  GW
Sbjct: 1066 GWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTG--RCLCPAGW 1110



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 54/210 (25%), Positives = 66/210 (31%), Gaps = 63/210 (30%)

Query: 257  CVSPKYGCNFNNGGCHQDCF-------EGGDGSFLCG-----------CRPGFRLLDDLV 298
            C   +YG       CH +C        E   G+  CG           C PGF       
Sbjct: 1335 CPPGRYGA-----ACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQG 1389

Query: 299  TCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQEC 358
             C  ++     P  G   C  G HG      C +G               C+     + C
Sbjct: 1390 LCWCQHGAPCDPISGRCLCPAGFHGH----FCERG---------------CEPGSFGEGC 1430

Query: 359  VNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRS------PCAQGCTNTDGSFHCSCE 412
                   RC+C  G  P  P  G C     C  GRS       C +G      + HC C 
Sbjct: 1431 HQ-----RCDC-DGGAPCDPVTGLCL----CPPGRSGATCNLDCRRGQFGPSCTLHCDCG 1480

Query: 413  EGYVLAGEDGTQCQDVDECVGP----GGPL 438
             G       G QC  VD  +GP    GGPL
Sbjct: 1481 GGADCDPVSG-QCHCVDGYMGPTCREGGPL 1509



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 46/178 (25%), Positives = 59/178 (33%), Gaps = 22/178 (12%)

Query: 300  CASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECV 359
            CA  N  S  P  G   C  G  G +    CP G   D+ +  C+  +     P +  C 
Sbjct: 1003 CACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCA 1062

Query: 360  NTPG--GFRC--ECWV-GYEPGGPGEGACQDVDEC--ALGRSPCAQGCTNTDGSFHCSCE 412
               G  G  C  EC       G    G C +   C    GR  C  G T       C   
Sbjct: 1063 CPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPC--- 1119

Query: 413  EGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMG 470
                L G  G  C     C  P G    + C +  G+  C C PG+  +    +C  G
Sbjct: 1120 ----LRGWFGEAC--AQRCSCPPG----AACHHVTGA--CRCPPGFTGSGCEQACPPG 1165


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score =  143 bits (361), Expect = 4e-34
 Identities = 82/214 (38%), Positives = 110/214 (51%), Gaps = 20/214 (9%)

Query: 264  CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATCVLGP 321
            C+  NGGC   C    +GS+ C C+PGF L+ D  +C   + C  +P  C GG  C   P
Sbjct: 1201 CSIMNGGCETFC-TNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGG-QCTNIP 1258

Query: 322  HGKNYTCRCPQGYQLDSSQLDCVDVDECQDSP---CAQECVNTPGGFRCECWVGYEPGGP 378
                Y C C  G+        CVDV+EC  +P    +  C NT G F C C +GY  G  
Sbjct: 1259 --GEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYS-GKK 1315

Query: 379  GEGACQDVDECALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGG 436
            G+  C D++EC +G   C +   CTNT GSF CSC  G++    DG +C D+DEC   G 
Sbjct: 1316 GKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWI---GDGIKCTDLDEC-SNGT 1371

Query: 437  PLCD--SLCFNTQGSFHCGCLPGWVLAPNGVSCT 468
             +C   + C NT GS+ C C  G+    +G +CT
Sbjct: 1372 HMCSQHADCKNTMGSYRCLCKEGY--TGDGFTCT 1403



 Score =  138 bits (348), Expect = 1e-32
 Identities = 78/194 (40%), Positives = 99/194 (51%), Gaps = 17/194 (8%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATC--VLGPHGKNYTCRCPQGYQLDS 338
            GSF C C  GF+  DD   C   N C    C G  TC   +G    ++ CRC  G+ L  
Sbjct: 1870 GSFYCLCHTGFKTNDDQTMCLDINECERDAC-GNGTCRNTIG----SFNCRCNHGFILSH 1924

Query: 339  SQLDCVDVDECQDSP---CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRS 394
            +  DC+DVDEC       C   +C+NT G F+C+C  GYE    G   C D++EC L   
Sbjct: 1925 NN-DCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGR-TCVDINECLLEPR 1982

Query: 395  PCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCG 453
             CA G C N DGS+ C C  GY L  E   +C+D+DECV          C NT+GSF C 
Sbjct: 1983 KCAPGTCQNLDGSYRCICPPGYSLQNE---KCEDIDECVEEPEICALGTCSNTEGSFKCL 2039

Query: 454  CLPGWVLAPNGVSC 467
            C  G+ L+ +G  C
Sbjct: 2040 CPEGFSLSSSGRRC 2053



 Score =  136 bits (342), Expect = 7e-32
 Identities = 82/216 (37%), Positives = 113/216 (52%), Gaps = 21/216 (9%)

Query: 257 CVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGAT 316
           C   +Y C   NG C         GS  C C  GF+L D    C   + C  +PC GG  
Sbjct: 453 CQLVRYLCQ--NGRCIPT-----PGSCRCECNKGFQL-DLRGECIDVDECEKNPCAGGE- 503

Query: 317 CVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGY 373
           C+   +  +YTC+C  GYQ   ++ +C D+DEC  +   C    C+NT G F C C  G+
Sbjct: 504 CI--NNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGF 561

Query: 374 EPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECV 432
                G+  C+D+DEC++ R+ C  G C N DGSF C C+ G+ LA  DG  C+D++EC 
Sbjct: 562 HVTRDGKN-CEDMDECSI-RNMCLNGMCINEDGSFKCICKPGFQLA-SDGRYCKDINECE 618

Query: 433 GPGGPLC-DSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
            PG  +C +  C NT GS+ C C PG  +  +G  C
Sbjct: 619 TPG--ICMNGRCVNTDGSYRCECFPGLAVGLDGRVC 652



 Score =  132 bits (333), Expect = 8e-31
 Identities = 87/255 (34%), Positives = 121/255 (47%), Gaps = 18/255 (7%)

Query: 220  AANVACGEGDKDETQSHYFLCKEKAPD-VFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEG 278
            A N  C +     T     LC  + P  V D  +  P+ +     C    G C       
Sbjct: 1728 AWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDE---CREIPGVCENGVCIN 1784

Query: 279  GDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP-CRGGATCVLGPHGKNYTCRCPQGYQLD 337
              GSF C C  GF   D L+ C   + C + P C+  A C+      +Y C C  GY+  
Sbjct: 1785 MVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECI--NTAGSYRCDCKPGYRFT 1842

Query: 338  SSQLDCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRS 394
            S+   C D +ECQ+ P  C+  +C++T G F C C  G++     +  C D++EC   R 
Sbjct: 1843 STG-QCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDD-QTMCLDINECE--RD 1898

Query: 395  PCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC-DSLCFNTQGSFHC 452
             C  G C NT GSF+C C  G++L+  +   C DVDEC    G LC +  C NT GSF C
Sbjct: 1899 ACGNGTCRNTIGSFNCRCNHGFILSHNN--DCIDVDECASGNGNLCRNGQCINTVGSFQC 1956

Query: 453  GCLPGWVLAPNGVSC 467
             C  G+ +AP+G +C
Sbjct: 1957 QCNEGYEVAPDGRTC 1971



 Score =  132 bits (332), Expect = 1e-30
 Identities = 79/208 (37%), Positives = 106/208 (50%), Gaps = 19/208 (9%)

Query: 267  NNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATC--VLGPH 322
            +N G H  C     GSF C C PG+  + D + C   + CS+    C   A C   +G  
Sbjct: 1331 HNCGKHAVCTNTA-GSFKCSCSPGW--IGDGIKCTDLDECSNGTHMCSQHADCKNTMG-- 1385

Query: 323  GKNYTCRCPQGYQLDSSQLDCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPG 379
              +Y C C +GY  D     C D+DEC ++   C   +C+N PGG+RCEC +G+ P   G
Sbjct: 1386 --SYRCLCKEGYTGDG--FTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADG 1441

Query: 380  EGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC 439
            + AC+D+DEC+L        C N  G F C CE GY L    G  C DV+EC+ P   + 
Sbjct: 1442 K-ACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYEL-DRSGGNCTDVNECLDPTTCIS 1499

Query: 440  DSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
             + C NT GS+ C C P + L P  V C
Sbjct: 1500 GN-CVNTPGSYICDCPPDFELNPTRVGC 1526



 Score =  130 bits (328), Expect = 3e-30
 Identities = 75/196 (38%), Positives = 103/196 (52%), Gaps = 15/196 (7%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATCVLGPHGKNYTCRCPQGYQLDS 338
            GSF C C  GF L  +   C   + C  SP  C G   CV  P   ++ C+C +GY+   
Sbjct: 1049 GSFKCRCDSGFALDSEERNCTDIDECRISPDLC-GRGQCVNTPG--DFECKCDEGYESGF 1105

Query: 339  SQL-DCVDVDECQDSPCAQE---CVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRS 394
              + +C+D+DECQ  P       C NT G +RCEC  G++   P   AC D++EC L   
Sbjct: 1106 MMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLS-PNISACIDINECELSAH 1164

Query: 395  PCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC-VGPGGPLCDSLCFNTQGSFHC 452
             C  G C N  G + C+C  GY  +  D   C D+DEC +  GG  C++ C N++GS+ C
Sbjct: 1165 LCPNGRCVNLIGKYQCACNPGYH-STPDRLFCVDIDECSIMNGG--CETFCTNSEGSYEC 1221

Query: 453  GCLPGWVLAPNGVSCT 468
             C PG+ L P+  SCT
Sbjct: 1222 SCQPGFALMPDQRSCT 1237



 Score =  124 bits (310), Expect = 4e-28
 Identities = 81/246 (32%), Positives = 109/246 (44%), Gaps = 56/246 (22%)

Query: 269  GGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC--SSSPCRGG----------AT 316
            G CH       +GS+ C C PG +L  ++  C   N C  S+  C  G            
Sbjct: 1127 GVCHNT-----EGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCA 1181

Query: 317  CVLGPHGK----------------------------NYTCRCPQGYQLDSSQLDCVDVDE 348
            C  G H                              +Y C C  G+ L   Q  C D+DE
Sbjct: 1182 CNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDE 1241

Query: 349  CQDSP--C-AQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTD 404
            C+D+P  C   +C N PG +RC C+ G+         C DV+EC L  + C  G C NT 
Sbjct: 1242 CEDNPNICDGGQCTNIPGEYRCLCYDGF-MASEDMKTCVDVNECDLNPNICLSGTCENTK 1300

Query: 405  GSFHCSCEEGYVLAGEDG-TQCQDVDEC-VGPGGPLCDSLCFNTQGSFHCGCLPGWVLAP 462
            GSF C C+ GY  +G+ G T C D++EC +G       ++C NT GSF C C PGW+   
Sbjct: 1301 GSFICHCDMGY--SGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWI--G 1356

Query: 463  NGVSCT 468
            +G+ CT
Sbjct: 1357 DGIKCT 1362



 Score =  117 bits (292), Expect = 4e-26
 Identities = 68/186 (36%), Positives = 89/186 (47%), Gaps = 14/186 (7%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSP---CRGGATCVLGPHGKNYTCRCPQGYQLD 337
            GS+ C C+PG+R       C  RN C   P     G     +G    ++ C C  G++ +
Sbjct: 1829 GSYRCDCKPGYRFTST-GQCNDRNECQEIPNICSHGQCIDTVG----SFYCLCHTGFKTN 1883

Query: 338  SSQLDCVDVDECQDSPCAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSP- 395
              Q  C+D++EC+   C    C NT G F C C  G+      +  C DVDECA G    
Sbjct: 1884 DDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNND--CIDVDECASGNGNL 1941

Query: 396  CAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGC 454
            C  G C NT GSF C C EGY +A  DG  C D++EC+          C N  GS+ C C
Sbjct: 1942 CRNGQCINTVGSFQCQCNEGYEVA-PDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCIC 2000

Query: 455  LPGWVL 460
             PG+ L
Sbjct: 2001 PPGYSL 2006



 Score =  117 bits (292), Expect = 4e-26
 Identities = 71/215 (33%), Positives = 97/215 (45%), Gaps = 10/215 (4%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQ 340
            G F C C PGF       +C   N C+S     G+  +      ++TC C +G+ LD + 
Sbjct: 2505 GGFTCKCPPGFT--QHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTG 2562

Query: 341  LDCVDVDECQDSP-CAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG 399
              C DVDEC+ +  C   C N  GG+RC C  GY         C D +EC          
Sbjct: 2563 SSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWN-QCVDENECLSAHICGGAS 2621

Query: 400  CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWV 459
            C NT GS+ C C  G+      G  CQD++EC     P C   C NT+G + CGC PG+ 
Sbjct: 2622 CHNTLGSYKCMCPAGFQYEQFSGG-CQDINECGSAQAP-CSYGCSNTEGGYLCGCPPGYF 2679

Query: 460  LAPNGVSCTMGPVSLGPPSGPPDEEDKGEKEGSTV 494
                G  C  G   +G   G P+    GE + +++
Sbjct: 2680 RIGQG-HCVSG---MGMGRGNPEPPVSGEMDDNSL 2710



 Score =  116 bits (290), Expect = 7e-26
 Identities = 90/318 (28%), Positives = 129/318 (40%), Gaps = 59/318 (18%)

Query: 159  KWSEGPCGSPGSPGSNIEGFVCKFSFKGMCRPLALGGPGQVTYTTPFQTTSSSLEAVPFA 218
            K+  G C SP S   + +   C    +G   P  L          P +   +  +  P+ 
Sbjct: 2064 KFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCEL---------CPTEPDEAFRQICPYG 2114

Query: 219  SAANVACGEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEG 278
            S   V   +   D  +     CKE  PDV   G     C++                   
Sbjct: 2115 SGIIVGPDDSAVDMDE-----CKE--PDVCKHGQ----CINT------------------ 2145

Query: 279  GDGSFLCGCRPGFRLLD----DLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGY 334
             DGS+ C C  G+ L      D   C+  NPC +  C+     V+G     + C C +G+
Sbjct: 2146 -DGSYRCECPFGYILAGNECVDTDECSVGNPCGNGTCKN----VIG----GFECTCEEGF 2196

Query: 335  QLDSSQLDCVDVDECQDSP--CAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALG 392
            +     + C D++EC  +P  CA  CVNT G + C+C VGY         C+D DEC  G
Sbjct: 2197 E-PGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLR-EDRRMCKDEDECEEG 2254

Query: 393  RSPCAQG---CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGS 449
            +  C +    C N  G++ C C  GY     DG  C D +EC    G   +  C NT+GS
Sbjct: 2255 KHDCTEKQMECKNLIGTYMCICGPGYQRR-PDGEGCVDENECQTKPGICENGRCLNTRGS 2313

Query: 450  FHCGCLPGWVLAPNGVSC 467
            + C C  G+  +PN   C
Sbjct: 2314 YTCECNDGFTASPNQDEC 2331



 Score =  113 bits (282), Expect = 6e-25
 Identities = 66/194 (34%), Positives = 94/194 (48%), Gaps = 13/194 (6%)

Query: 281  GSFLCGCRPGFRL-LDDLVTCASRNPCSSSP--CRGGATCVLGPHGKNYTCRCPQGYQLD 337
            G F C C  G+      +  C   + C   P  CRGG   V      +Y C CP G+QL 
Sbjct: 1091 GDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGG---VCHNTEGSYRCECPPGHQLS 1147

Query: 338  SSQLDCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRS 394
             +   C+D++EC+ S   C    CVN  G ++C C  GY    P    C D+DEC++   
Sbjct: 1148 PNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYH-STPDRLFCVDIDECSIMNG 1206

Query: 395  PCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCD-SLCFNTQGSFHCG 453
             C   CTN++GS+ CSC+ G+ L   D   C D+DEC      +CD   C N  G + C 
Sbjct: 1207 GCETFCTNSEGSYECSCQPGFALM-PDQRSCTDIDEC-EDNPNICDGGQCTNIPGEYRCL 1264

Query: 454  CLPGWVLAPNGVSC 467
            C  G++ + +  +C
Sbjct: 1265 CYDGFMASEDMKTC 1278



 Score =  112 bits (279), Expect = 1e-24
 Identities = 91/278 (32%), Positives = 116/278 (41%), Gaps = 47/278 (16%)

Query: 225  CGEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYG---CNFNNGGCH--------- 272
            C  G    T+  +   K   P+ F   SSG  C   +       F  G C          
Sbjct: 2024 CALGTCSNTEGSF---KCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSK 2080

Query: 273  QDCF-----EG-GDGSFLCGCRP--GFRLL----DDLVTCASRNPCSSSPCRGGATCVLG 320
            Q+C      EG GD   LC   P   FR +      ++     +      C+    C   
Sbjct: 2081 QECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVC--- 2137

Query: 321  PHGK------NYTCRCPQGYQLDSSQLDCVDVDECQ-DSPCAQ-ECVNTPGGFRCECWVG 372
             HG+      +Y C CP GY L  ++  CVD DEC   +PC    C N  GGF C C  G
Sbjct: 2138 KHGQCINTDGSYRCECPFGYILAGNE--CVDTDECSVGNPCGNGTCKNVIGGFECTCEEG 2195

Query: 373  YEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECV 432
            +EPG      C+D++ECA     CA  C NT GS+ C C  GYVL  ED   C+D DEC 
Sbjct: 2196 FEPGPMM--TCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLR-EDRRMCKDEDEC- 2251

Query: 433  GPGGPLCDSL---CFNTQGSFHCGCLPGWVLAPNGVSC 467
              G   C      C N  G++ C C PG+   P+G  C
Sbjct: 2252 EEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGC 2289



 Score =  108 bits (270), Expect = 2e-23
 Identities = 75/227 (33%), Positives = 97/227 (42%), Gaps = 38/227 (16%)

Query: 264  CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTC---------------------AS 302
            C    G C         GS+ C C  GF    +   C                     ++
Sbjct: 2295 CQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSN 2354

Query: 303  RNPCSSSPC-----RG-GATCVLGPHGKNYTCR--CPQGYQLDSSQLDCVDVDECQ---D 351
            RNP + S C     RG G  C + P       +  CP G    ++     D+DEC+   D
Sbjct: 2355 RNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNG---ADIDECKVIHD 2411

Query: 352  SPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSC 411
                 ECVN  G + C C  GY P   G  +C D++EC     PC   C NT+GS+ CSC
Sbjct: 2412 VCRNGECVNDRGSYHCICKTGYTPDITGT-SCVDLNECNQAPKPCNFICKNTEGSYQCSC 2470

Query: 412  EEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGW 458
             +GY+L  EDG  C+D+DEC       C  LC NT G F C C PG+
Sbjct: 2471 PKGYILQ-EDGRSCKDLDECATKQHN-CQFLCVNTIGGFTCKCPPGF 2515



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 72/221 (32%), Positives = 99/221 (44%), Gaps = 41/221 (18%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATCVLGPHGKNYTCRCPQGYQLDS 338
            G+++C C PG++   D   C   N C + P  C  G    L   G +YTC C  G+    
Sbjct: 2270 GTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRC--LNTRG-SYTCECNDGFTASP 2326

Query: 339  SQLDCVDVDE-----------CQ------DSPCAQECVNTPG---GFRCECW-----VGY 373
            +Q +C+D  E           CQ      +     EC    G   G  CE       V +
Sbjct: 2327 NQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAF 2386

Query: 374  E---PGGPG---EGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQ 426
            +   P G G    GA  D+DEC +    C  G C N  GS+HC C+ GY      GT C 
Sbjct: 2387 KKLCPHGRGFMTNGA--DIDECKVIHDVCRNGECVNDRGSYHCICKTGYT-PDITGTSCV 2443

Query: 427  DVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
            D++EC     P C+ +C NT+GS+ C C  G++L  +G SC
Sbjct: 2444 DLNECNQAPKP-CNFICKNTEGSYQCSCPKGYILQEDGRSC 2483



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 66/228 (28%), Positives = 94/228 (41%), Gaps = 28/228 (12%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC--SSSPCRGGATCVLGP 321
           C  +   C     E   G++ C C  G+ +      C   N C  +S  C  G  C   P
Sbjct: 727 CALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQ-CRNTP 785

Query: 322 HGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQE-CVNTPGGFRCECWVGYEPGGPGE 380
              ++ C CP+G+        C D+DEC+ SPC    C N+PG F CEC        P +
Sbjct: 786 G--SFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICEC-SSESTLDPTK 842

Query: 381 GACQDV-----------DECAL---GRSPCAQGCTNTDGSFHCSCEEGYV--LAGED--- 421
             C +              C +   G +  +Q C++   ++   C    V  + G+    
Sbjct: 843 TICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSR 902

Query: 422 --GTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
             GTQC+D+DEC    G   + LC NT+GSF C C  G  L   G  C
Sbjct: 903 IKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRIC 950



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 81/263 (30%), Positives = 101/263 (38%), Gaps = 67/263 (25%)

Query: 242  EKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCA 301
            E APD       G  CV     C      C     +  DGS+ C C PG+ L ++   C 
Sbjct: 1963 EVAPD-------GRTCVDINE-CLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNE--KCE 2012

Query: 302  SRNPCSSSPCRGGATCVLGPHGK---NYTCRCPQGYQLDSSQLDCVDV------------ 346
              + C   P      C LG       ++ C CP+G+ L SS   C D+            
Sbjct: 2013 DIDECVEEP----EICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGG 2068

Query: 347  ------------DEC--------QDSPCAQECVNTPG-GFRCECWVGYEPG---GPGEGA 382
                         EC           PC + C   P   FR  C   Y  G   GP + A
Sbjct: 2069 KCSSPKSRNHSKQECCCALKGEGWGDPC-ELCPTEPDEAFRQIC--PYGSGIIVGPDDSA 2125

Query: 383  CQDVDECALGRSP--CAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC 439
              D+DEC   + P  C  G C NTDGS+ C C  GY+LA   G +C D DEC   G P  
Sbjct: 2126 V-DMDEC---KEPDVCKHGQCINTDGSYRCECPFGYILA---GNECVDTDEC-SVGNPCG 2177

Query: 440  DSLCFNTQGSFHCGCLPGWVLAP 462
            +  C N  G F C C  G+   P
Sbjct: 2178 NGTCKNVIGGFECTCEEGFEPGP 2200



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 70/223 (31%), Positives = 86/223 (38%), Gaps = 39/223 (17%)

Query: 271 CHQDCFEGGDGSF-LCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCR 329
           C+  C  GG  S   C C+ G+      +      P   S C  G  CV  P+     C 
Sbjct: 119 CNIRCMNGGSCSDDHCLCQKGY------IGTHCGQPVCESGCLNGGRCV-APN----RCA 167

Query: 330 CPQGYQLDSSQLD-----CVDV---DECQDSPCAQECVNT--------PGGFRCE----- 368
           C  G+     + D     C  V     CQ       C  T          G  CE     
Sbjct: 168 CTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ 227

Query: 369 ---CWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQ 424
              C  G+ P     GACQDVDEC      C  G C NT GSF C C  G+ L  E   +
Sbjct: 228 PHPCRRGFIPN-IRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKL-NEVSQK 285

Query: 425 CQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
           C+D+DEC    G      C NT  S+ C C PG+  +P+G  C
Sbjct: 286 CEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRC 328



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 64/227 (28%), Positives = 86/227 (37%), Gaps = 51/227 (22%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATC--VLGPHGKNYTCRCPQGYQLDS 338
            GSF C C  G+ L +D   C   N C +    G  TC   +G    NYTC CP  Y   +
Sbjct: 1627 GSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVG----NYTCICPPDYMQVN 1682

Query: 339  SQLDCVD-----------------------------------VDECQDSPCAQECVNTPG 363
               +C+D                                   +    + PC Q  + +  
Sbjct: 1683 GGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTD 1742

Query: 364  GFRCECWVGYEPGGPGE---GACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAG 419
             F   C     PG   +   G   D+DEC      C  G C N  GSF C C  G+    
Sbjct: 1743 EFATLCG-SQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGF-FYN 1800

Query: 420  EDGTQCQDVDECVGPGGPLC--DSLCFNTQGSFHCGCLPGWVLAPNG 464
            +    C+D+DEC    GP+C  ++ C NT GS+ C C PG+     G
Sbjct: 1801 DKLLVCEDIDEC--QNGPVCQRNAECINTAGSYRCDCKPGYRFTSTG 1845



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 70/266 (26%), Positives = 103/266 (38%), Gaps = 62/266 (23%)

Query: 239 LCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLV 298
           L + +  D+ +   +G +C         NNG C        DGSF C C  GF +  D  
Sbjct: 523 LTRTECRDIDECLQNGRIC---------NNGRCINT-----DGSFHCVCNAGFHVTRDGK 568

Query: 299 TCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQE- 357
            C   + CS         C+      ++ C C  G+QL S    C D++EC+        
Sbjct: 569 NCEDMDECSIRNMCLNGMCI--NEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNG 626

Query: 358 -CVNTPGGFRCECWVGYEPGGPGEGACQDVD------------EC------ALGRSPCAQ 398
            CVNT G +RCEC+ G   G  G   C D              +C      A+ +S C  
Sbjct: 627 RCVNTDGSYRCECFPGLAVGLDGR-VCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECC- 684

Query: 399 GCTNTDGSFH-----------------CSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS 441
            C +T+ +F                  CS   G   AG D  +C  +D  + P G     
Sbjct: 685 -CASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECA-LDPDICPNG----- 737

Query: 442 LCFNTQGSFHCGCLPGWVLAPNGVSC 467
           +C N +G++ C C  G+ +   G +C
Sbjct: 738 ICENLRGTYKCICNSGYEVDSTGKNC 763



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 76/279 (27%), Positives = 100/279 (35%), Gaps = 49/279 (17%)

Query: 229  DKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYG----------CNFNNGGCHQDCFEG 278
            D DE  +   +C + A      GS   LC     G          C+ N   C       
Sbjct: 1363 DLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLN 1422

Query: 279  GDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDS 338
              G + C C  GF    D   C   + CS        TC   P    + C C  GY+LD 
Sbjct: 1423 APGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPG--LFRCECEIGYELDR 1480

Query: 339  SQLDCVDVDECQD-SPCAQ-ECVNTPGGFRCECWVGYE---------------------- 374
            S  +C DV+EC D + C    CVNTPG + C+C   +E                      
Sbjct: 1481 SGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRP 1540

Query: 375  PGGPGEGACQD-----VDE----CALGRS---PCAQGCTNTDGSFHCSCEEGYVLAGEDG 422
             G  G+ AC +     V +    C+LG++   PC          +   C  G        
Sbjct: 1541 RGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPI 1600

Query: 423  TQC-QDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVL 460
            T   +D+DEC    G      C NT GSF C C  G+ L
Sbjct: 1601 TVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYL 1639



 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 40/116 (34%), Positives = 53/116 (45%), Gaps = 9/116 (7%)

Query: 268  NGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATC--VLGPHGKN 325
            N  C   C +   G + C C  G+        C   N C S+   GGA+C   LG    +
Sbjct: 2574 NHRCQHGC-QNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLG----S 2628

Query: 326  YTCRCPQGYQLDSSQLDCVDVDEC--QDSPCAQECVNTPGGFRCECWVGYEPGGPG 379
            Y C CP G+Q +     C D++EC    +PC+  C NT GG+ C C  GY   G G
Sbjct: 2629 YKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGYFRIGQG 2684



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 62/235 (26%), Positives = 85/235 (36%), Gaps = 51/235 (21%)

Query: 284  LCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATCVLGPHGKNYTCRCPQGYQLDSSQL 341
            LC    GFR     V     + C   P  C+GG    +   G ++ CRCP GY L+    
Sbjct: 1588 LCPGGEGFRPNPITVILEDIDECQELPGLCQGGKC--INTFG-SFQCRCPTGYYLNEDTR 1644

Query: 342  DCVDVDECQDSPCA--QECVNTPGGFRCECWVGYEPGGPGEGACQDVDE----------- 388
             C DV+EC+         C NT G + C C   Y     G   C D+             
Sbjct: 1645 VCDDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNN-CMDMRRSLCYRNYYADN 1703

Query: 389  -----------------CA--LGRS---PCAQGCTNTDGSFHCSC---EEGYVLAGEDGT 423
                             C+  +GR+   PC Q    +   F   C     G+V+    G 
Sbjct: 1704 QTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGL 1763

Query: 424  QCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGW------VLAPNGVSCTMGPV 472
               D+DEC    G   + +C N  GSF C C  G+      ++  +   C  GPV
Sbjct: 1764 PV-DIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPV 1817



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 72/320 (22%), Positives = 102/320 (31%), Gaps = 103/320 (32%)

Query: 248  FDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTC-----AS 302
            ++  S+G  CV     C  N+  C         GSF+C C  GF    DL TC       
Sbjct: 754  YEVDSTGKNCVDINE-CVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECE 812

Query: 303  RNPCSSSPCRGG--------------------------ATC------------VLGPHGK 324
             +PC +  C+                             TC            + G   K
Sbjct: 813  SSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLK 872

Query: 325  NYTCR------------------CPQGY-QLDSSQLDCVDVDECQDSPCAQE---CVNTP 362
            +  C                   C +GY ++  +Q  C D+DEC+  P   +   CVNT 
Sbjct: 873  SQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQ--CEDIDECEVFPGVCKNGLCVNTR 930

Query: 363  GGFRCECWVGYEPGGPGEGACQDV-----------DECAL-------------------G 392
            G F+C+C  G      G   C D+           +EC L                   G
Sbjct: 931  GSFKCQCPSGMTLDATGR-ICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWG 989

Query: 393  RSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQ----CQDVDECVGPGGPLCDSLCFNTQG 448
               C +        +   C  G   A ++ T      +D++EC           C NT G
Sbjct: 990  TEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIG 1049

Query: 449  SFHCGCLPGWVLAPNGVSCT 468
            SF C C  G+ L     +CT
Sbjct: 1050 SFKCRCDSGFALDSEERNCT 1069



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 32/118 (27%), Positives = 46/118 (38%), Gaps = 24/118 (20%)

Query: 250 WGSSGPLCVSPKYGC------NFNNGGCHQ--DC------FEGGD-----GSFLCGCRPG 290
           WG    +C +  + C      N   G C    +C       +GG+     GSF C C  G
Sbjct: 217 WGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAG 276

Query: 291 FRLLDDLVTCASRNPCSSSP--CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDV 346
            +L +    C   + CS+ P  C GG          +Y C+CP G+        C+DV
Sbjct: 277 HKLNEVSQKCEDIDECSTIPGICEGGECTNTV---SSYFCKCPPGFYTSPDGTRCIDV 331


>gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens]
          Length = 955

 Score =  142 bits (359), Expect = 7e-34
 Identities = 105/301 (34%), Positives = 135/301 (44%), Gaps = 38/301 (12%)

Query: 300 CASRNPCSSSPCRGGATC-----VLGPHGKNYTCR----------CPQGYQLDSSQ--LD 342
           C + N CS      GATC       G +G + TC           CP G+ +  +   + 
Sbjct: 80  CIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIR 139

Query: 343 CVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTN 402
           C D+DEC  S C   CVNT GGF CEC  G +       +CQD DEC LG +PC Q C N
Sbjct: 140 CTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSA-DRHSCQDTDEC-LG-TPCQQRCKN 196

Query: 403 TDGSFHCSCEEGYVLAGEDGTQCQDVDECVGP-GGPLCDSLCFNTQGSFHCGCLPGWVLA 461
           + GS+ CSC  G+ L G +   C DV+EC  P    +C   C NT GSF C C PG+ L 
Sbjct: 197 SIGSYKCSCRTGFHLHG-NRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLR 255

Query: 462 PNGVSCTMGPVSLGPPSGPPDEEDKGEKEGSTVPRAATA------SPTRGPEGTPKATPT 515
            + VSC   P ++  PS          K    +P A         SP  G  G P    T
Sbjct: 256 ADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPGPPAGVRT 315

Query: 516 TSRPSLSSDAPIT--SAPLKMLA-------PSGS-PGVWREPSIHHATAASGPQEPAGGD 565
           T  PS +   P +  SAP+ +L+       P+ S  G  R PS+        P  P G +
Sbjct: 316 TRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPE 375

Query: 566 S 566
           S
Sbjct: 376 S 376



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 111/468 (23%), Positives = 151/468 (32%), Gaps = 107/468 (22%)

Query: 161 SEGPCGSPGSPGSNIEGFVCKFSFKGMCRPLALGGPGQVTYTTPFQTTSSSLEAVP---- 216
           +EG   SP  P  N    VC         P    GP Q    TP QT   +   V     
Sbjct: 451 AEGDVFSP--PNENCTVCVCLAGNVSCISPECPSGPCQ----TPPQTDCCTCVPVRCYFH 504

Query: 217 ---FASAANVACGEGDK--------DETQSHYFLCKEKAPDVFDWGSSGPLCV------S 259
              +A  A V  G GD+         E +  +  C E A    +W      C       +
Sbjct: 505 GRWYADGA-VFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPT 563

Query: 260 PKYGCNFNNGGCH---QDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSS---PCR- 312
           P  GC+ ++ G        +  GD   LC C+      D  V+C  R  C  S   P R 
Sbjct: 564 PSTGCSLDDNGVEFPIGQIWSPGDPCELCICQA-----DGSVSC-KRTDCVDSCPHPIRI 617

Query: 313 GGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCE---- 368
            G  C     G  YT R     +   S LD          PC   C+   G   C     
Sbjct: 618 PGQCCPDCSAGCTYTGRIFYNNETFPSVLD----------PCLS-CICLLGSVACSPVDC 666

Query: 369 ---CWVGYEPGGPGEGACQDVDE----------CALGRSPCAQGCTNTDGSFHC------ 409
              C   + P G     C+D +             L   PC + CT   G   C      
Sbjct: 667 PITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTR-CTCQLGEVSCEKVPCQ 725

Query: 410 -SCEEGYVLAGEDGTQCQD----VDECVG--PGGPLC-----DSLCFNTQGSFHCGCLPG 457
            +C +  +L G+  + C D    ++E  G  P G +       SL  +T+   +C   PG
Sbjct: 726 RACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPG 785

Query: 458 ---------------WVLAPNGVSCTMGPVSLGPPSGPPDEEDKGEKEGSTVPRAATASP 502
                           +L  N +     P S   P+G            +T P    ASP
Sbjct: 786 PPTASPSRPVLHLLQLLLRTNLMKTQTLPTS---PAGAHGPHSLALGLTATFPGEPGASP 842

Query: 503 TRGP-EGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSPGVWREPSI 549
              P   TP   PT    S  +  P    P +  + SG+  V R P +
Sbjct: 843 RLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPL 890



 Score = 30.0 bits (66), Expect = 7.0
 Identities = 21/63 (33%), Positives = 27/63 (42%), Gaps = 10/63 (15%)

Query: 450 FHCGCLPGWVLAPNGVSCTMGPVSLGPPSG----PPDEEDKGEKEGSTVPRAATASPTRG 505
           F  GC PGW  +  G  CT+   S G  SG    P     +  ++G+T P       T G
Sbjct: 49  FGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPE------THG 102

Query: 506 PEG 508
           P G
Sbjct: 103 PCG 105


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score =  140 bits (354), Expect = 3e-33
 Identities = 76/196 (38%), Positives = 108/196 (55%), Gaps = 18/196 (9%)

Query: 280  DGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGK---NYTCRCPQGYQL 336
            +GS++C C  G+    D   C   + C       G  CV G       ++ C C QGYQL
Sbjct: 1058 EGSYMCSCHKGYTRTPDHKHCRDIDECQQ-----GNLCVNGQCKNTEGSFRCTCGQGYQL 1112

Query: 337  DSSQLDCVDVDECQDSP-CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRS 394
             +++  C D+DECQ    CA  +C NT G F+C C  GY   G G+  C+D++EC   +S
Sbjct: 1113 SAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDH-CEDINECLEDKS 1171

Query: 395  PCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC--DSLCFNTQGSFH 451
             C +G C NT GS+ C+C +G+ L  +D   CQD++EC  PG  LC     C NT+GSFH
Sbjct: 1172 VCQRGDCINTAGSYDCTCPDGFQL--DDNKTCQDINECEHPG--LCGPQGECLNTEGSFH 1227

Query: 452  CGCLPGWVLAPNGVSC 467
            C C  G+ ++ +G +C
Sbjct: 1228 CVCQQGFSISADGRTC 1243



 Score =  115 bits (288), Expect = 1e-25
 Identities = 77/204 (37%), Positives = 102/204 (50%), Gaps = 18/204 (8%)

Query: 271  CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCV--LGPHGKNYTC 328
            C Q   E  +GSFLC C  GF   ++   C   + C      G   CV  +G     Y  
Sbjct: 927  CSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEY-- 984

Query: 329  RCPQGYQLDSSQLDCVDVDEC-QDSPCAQE-CVNTPGGFRC-ECWVGYEPGGPGEGACQD 385
             C  GY++ + +  C D+DEC   S C  E CVN+PG ++C  C  G+       G C D
Sbjct: 985  -CDSGYRM-TQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFR---GWNGQCLD 1039

Query: 386  VDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC-DSLC 443
            VDEC L  + CA G C+N +GS+ CSC +GY     D   C+D+DEC    G LC +  C
Sbjct: 1040 VDEC-LEPNVCANGDCSNLEGSYMCSCHKGYTRT-PDHKHCRDIDEC--QQGNLCVNGQC 1095

Query: 444  FNTQGSFHCGCLPGWVLAPNGVSC 467
             NT+GSF C C  G+ L+     C
Sbjct: 1096 KNTEGSFRCTCGQGYQLSAAKDQC 1119



 Score =  102 bits (253), Expect = 1e-21
 Identities = 68/197 (34%), Positives = 96/197 (48%), Gaps = 24/197 (12%)

Query: 281  GSFLCG-CRPGFRLL-----DDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGY 334
            G+F C  C  G+R+      +D+  C + + C    C       +   G      C +G+
Sbjct: 978  GAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQC-------VNSPGSYQCVPCTEGF 1030

Query: 335  QLDSSQLDCVDVDEC-QDSPCAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALG 392
            +  + Q  C+DVDEC + + CA  +C N  G + C C  GY    P    C+D+DEC  G
Sbjct: 1031 RGWNGQ--CLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRT-PDHKHCRDIDECQQG 1087

Query: 393  RSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC-DSLCFNTQGSF 450
               C  G C NT+GSF C+C +GY L+     QC+D+DEC      LC    C NT+GSF
Sbjct: 1088 NL-CVNGQCKNTEGSFRCTCGQGYQLSAAK-DQCEDIDEC--QHRHLCAHGQCRNTEGSF 1143

Query: 451  HCGCLPGWVLAPNGVSC 467
             C C  G+  +  G  C
Sbjct: 1144 QCVCDQGYRASGLGDHC 1160



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 61/156 (39%), Positives = 79/156 (50%), Gaps = 15/156 (9%)

Query: 304  NPCSSSP--CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSP--CAQ-EC 358
            N C+ +P  C G   C+  P    YTC C +GY+    Q  CVD+DEC      C+Q  C
Sbjct: 876  NECTVNPDIC-GAGHCINLP--VRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRC 932

Query: 359  VNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCS-CEEGYV 416
             NT G F C C  G+     G   C DVDEC L    C +G C NT G+F C  C+ GY 
Sbjct: 933  ENTEGSFLCICPAGFMASEEGTN-CIDVDEC-LRPDVCGEGHCVNTVGAFRCEYCDSGYR 990

Query: 417  LAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHC 452
            +      +C+D+DEC+ P     D  C N+ GS+ C
Sbjct: 991  MTQRG--RCEDIDECLNP-STCPDEQCVNSPGSYQC 1023



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 74/260 (28%), Positives = 95/260 (36%), Gaps = 62/260 (23%)

Query: 267  NNGGCHQDCF-EGGDGSFLCGCRPGFRLLDDLVTCASRNPCS--SSPC--------RGGA 315
            NN  C    F +   GSF C C  GF+   D   C   N C   S  C         G  
Sbjct: 1251 NNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSF 1310

Query: 316  TCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQD------------SPC--------- 354
             CV     + Y+    Q     S+ LD VDVD+ ++            S C         
Sbjct: 1311 LCVCADENQEYSPMTGQCRSRTSTDLD-VDVDQPKEEKKECYYNLNDASLCDNVLAPNVT 1369

Query: 355  AQECVNTPG---GFRCECWV-----------------GYEPGGPGEGAC-----QDVDEC 389
             QEC  T G   G  CE +                  G+ P G           +D DEC
Sbjct: 1370 KQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADEC 1429

Query: 390  AL-GRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQ 447
             L G+  C  G C NT   + C C++G         QC D+DEC  P   + D  C NT+
Sbjct: 1430 LLFGQEICKNGFCLNTRPGYECYCKQG-TYYDPVKLQCFDMDECQDPSSCI-DGQCVNTE 1487

Query: 448  GSFHCGCLPGWVLAPNGVSC 467
            GS++C C    VL  +   C
Sbjct: 1488 GSYNCFCTHPMVLDASEKRC 1507



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 30/71 (42%), Positives = 40/71 (56%), Gaps = 9/71 (12%)

Query: 311  CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQD-----SPCAQ-ECVNTPGG 364
            C  G  CV    G  YTC C  GY LD++++ CVDV+EC +     S C   +C+NT G 
Sbjct: 1632 CENGR-CVRVQEG--YTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGS 1688

Query: 365  FRCECWVGYEP 375
            ++C C  GY P
Sbjct: 1689 YKCLCLPGYVP 1699



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 28/84 (33%), Positives = 41/84 (48%), Gaps = 2/84 (2%)

Query: 385 DVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLC 443
           +++EC +    C  G C N    + C C EGY  + E   +C D+DEC           C
Sbjct: 874 EINECTVNPDICGAGHCINLPVRYTCICYEGYRFS-EQQRKCVDIDECTQVQHLCSQGRC 932

Query: 444 FNTQGSFHCGCLPGWVLAPNGVSC 467
            NT+GSF C C  G++ +  G +C
Sbjct: 933 ENTEGSFLCICPAGFMASEEGTNC 956



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 77/318 (24%), Positives = 105/318 (33%), Gaps = 69/318 (21%)

Query: 275 CFEGGDGSFLCGCRPGFRLLDDLV----TCASRNPCSSSPCRGGATCVLGPHGKNYTCRC 330
           CF+   GS      PG    +D      T    N C   P +         HG N    C
Sbjct: 559 CFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSY------HGYNQMMEC 612

Query: 331 PQGYQLDSSQLDCVDVDECQ-DSPCAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDE 388
             GY+  ++   C D++ECQ    C   EC+NT G +RC C +G+ P         D   
Sbjct: 613 LPGYKRVNNTF-CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPV 671

Query: 389 CALGRSPCAQGCTNTDGSFH----------CSCEEGYVLAGEDGTQCQDVDECVGPGGPL 438
            +  + PC +  ++     H          C C  G       G  C   ++C  PG   
Sbjct: 672 ISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAW----GPHC---EKCPLPGTAA 724

Query: 439 CDSLCFNTQG------------SFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGPPDEE-- 484
              +C    G              H G  P +V   N         S  PP  P  EE  
Sbjct: 725 FKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAK---STHPPPLPAKEEPV 781

Query: 485 -----DKGEKEGSTVPRAATASP-----------TRGPEGTPKATPTTSRPSLSSDAP-- 526
                 +    G   P  ATA P           T+   G P+ +P  S   L    P  
Sbjct: 782 EALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQFPGI 841

Query: 527 ---ITSAPLKM-LAPSGS 540
               TS P+ + +AP  S
Sbjct: 842 VIEKTSPPVPVEVAPEAS 859



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 31/86 (36%), Positives = 43/86 (50%), Gaps = 6/86 (6%)

Query: 387  DECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC--VGPGGPLC-DSL 442
            +EC +  + C  G C      + C C +GY L     T C DV+EC  +     LC ++ 
Sbjct: 1624 EECGI-LNGCENGRCVRVQEGYTCDCFDGYHLDTAKMT-CVDVNECDELNNRMSLCKNAK 1681

Query: 443  CFNTQGSFHCGCLPGWVLAPNGVSCT 468
            C NT GS+ C CLPG+V +     CT
Sbjct: 1682 CINTDGSYKCLCLPGYVPSDKPNYCT 1707


>gi|46249412 latent transforming growth factor beta binding protein
           1 isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score =  140 bits (354), Expect = 3e-33
 Identities = 76/196 (38%), Positives = 108/196 (55%), Gaps = 18/196 (9%)

Query: 280 DGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGK---NYTCRCPQGYQL 336
           +GS++C C  G+    D   C   + C       G  CV G       ++ C C QGYQL
Sbjct: 732 EGSYMCSCHKGYTRTPDHKHCRDIDECQQ-----GNLCVNGQCKNTEGSFRCTCGQGYQL 786

Query: 337 DSSQLDCVDVDECQDSP-CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRS 394
            +++  C D+DECQ    CA  +C NT G F+C C  GY   G G+  C+D++EC   +S
Sbjct: 787 SAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDH-CEDINECLEDKS 845

Query: 395 PCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC--DSLCFNTQGSFH 451
            C +G C NT GS+ C+C +G+ L  +D   CQD++EC  PG  LC     C NT+GSFH
Sbjct: 846 VCQRGDCINTAGSYDCTCPDGFQL--DDNKTCQDINECEHPG--LCGPQGECLNTEGSFH 901

Query: 452 CGCLPGWVLAPNGVSC 467
           C C  G+ ++ +G +C
Sbjct: 902 CVCQQGFSISADGRTC 917



 Score =  115 bits (288), Expect = 1e-25
 Identities = 77/204 (37%), Positives = 102/204 (50%), Gaps = 18/204 (8%)

Query: 271 CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCV--LGPHGKNYTC 328
           C Q   E  +GSFLC C  GF   ++   C   + C      G   CV  +G     Y  
Sbjct: 601 CSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEY-- 658

Query: 329 RCPQGYQLDSSQLDCVDVDEC-QDSPCAQE-CVNTPGGFRC-ECWVGYEPGGPGEGACQD 385
            C  GY++ + +  C D+DEC   S C  E CVN+PG ++C  C  G+       G C D
Sbjct: 659 -CDSGYRM-TQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFR---GWNGQCLD 713

Query: 386 VDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC-DSLC 443
           VDEC L  + CA G C+N +GS+ CSC +GY     D   C+D+DEC    G LC +  C
Sbjct: 714 VDEC-LEPNVCANGDCSNLEGSYMCSCHKGYTRT-PDHKHCRDIDEC--QQGNLCVNGQC 769

Query: 444 FNTQGSFHCGCLPGWVLAPNGVSC 467
            NT+GSF C C  G+ L+     C
Sbjct: 770 KNTEGSFRCTCGQGYQLSAAKDQC 793



 Score =  102 bits (253), Expect = 1e-21
 Identities = 68/197 (34%), Positives = 96/197 (48%), Gaps = 24/197 (12%)

Query: 281 GSFLCG-CRPGFRLL-----DDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGY 334
           G+F C  C  G+R+      +D+  C + + C    C       +   G      C +G+
Sbjct: 652 GAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQC-------VNSPGSYQCVPCTEGF 704

Query: 335 QLDSSQLDCVDVDEC-QDSPCAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALG 392
           +  + Q  C+DVDEC + + CA  +C N  G + C C  GY    P    C+D+DEC  G
Sbjct: 705 RGWNGQ--CLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRT-PDHKHCRDIDECQQG 761

Query: 393 RSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC-DSLCFNTQGSF 450
              C  G C NT+GSF C+C +GY L+     QC+D+DEC      LC    C NT+GSF
Sbjct: 762 NL-CVNGQCKNTEGSFRCTCGQGYQLSAAK-DQCEDIDEC--QHRHLCAHGQCRNTEGSF 817

Query: 451 HCGCLPGWVLAPNGVSC 467
            C C  G+  +  G  C
Sbjct: 818 QCVCDQGYRASGLGDHC 834



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 61/156 (39%), Positives = 79/156 (50%), Gaps = 15/156 (9%)

Query: 304 NPCSSSP--CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSP--CAQ-EC 358
           N C+ +P  C G   C+  P    YTC C +GY+    Q  CVD+DEC      C+Q  C
Sbjct: 550 NECTVNPDIC-GAGHCINLP--VRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRC 606

Query: 359 VNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCS-CEEGYV 416
            NT G F C C  G+     G   C DVDEC L    C +G C NT G+F C  C+ GY 
Sbjct: 607 ENTEGSFLCICPAGFMASEEGTN-CIDVDEC-LRPDVCGEGHCVNTVGAFRCEYCDSGYR 664

Query: 417 LAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHC 452
           +      +C+D+DEC+ P     D  C N+ GS+ C
Sbjct: 665 MTQRG--RCEDIDECLNP-STCPDEQCVNSPGSYQC 697



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 74/260 (28%), Positives = 95/260 (36%), Gaps = 62/260 (23%)

Query: 267  NNGGCHQDCF-EGGDGSFLCGCRPGFRLLDDLVTCASRNPCS--SSPC--------RGGA 315
            NN  C    F +   GSF C C  GF+   D   C   N C   S  C         G  
Sbjct: 925  NNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSF 984

Query: 316  TCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQD------------SPC--------- 354
             CV     + Y+    Q     S+ LD VDVD+ ++            S C         
Sbjct: 985  LCVCADENQEYSPMTGQCRSRTSTDLD-VDVDQPKEEKKECYYNLNDASLCDNVLAPNVT 1043

Query: 355  AQECVNTPG---GFRCECWV-----------------GYEPGGPGEGAC-----QDVDEC 389
             QEC  T G   G  CE +                  G+ P G           +D DEC
Sbjct: 1044 KQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADEC 1103

Query: 390  AL-GRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQ 447
             L G+  C  G C NT   + C C++G         QC D+DEC  P   + D  C NT+
Sbjct: 1104 LLFGQEICKNGFCLNTRPGYECYCKQG-TYYDPVKLQCFDMDECQDPSSCI-DGQCVNTE 1161

Query: 448  GSFHCGCLPGWVLAPNGVSC 467
            GS++C C    VL  +   C
Sbjct: 1162 GSYNCFCTHPMVLDASEKRC 1181



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 30/71 (42%), Positives = 40/71 (56%), Gaps = 9/71 (12%)

Query: 311  CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQD-----SPCAQ-ECVNTPGG 364
            C  G  CV    G  YTC C  GY LD++++ CVDV+EC +     S C   +C+NT G 
Sbjct: 1306 CENGR-CVRVQEG--YTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGS 1362

Query: 365  FRCECWVGYEP 375
            ++C C  GY P
Sbjct: 1363 YKCLCLPGYVP 1373



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 28/84 (33%), Positives = 41/84 (48%), Gaps = 2/84 (2%)

Query: 385 DVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLC 443
           +++EC +    C  G C N    + C C EGY  + E   +C D+DEC           C
Sbjct: 548 EINECTVNPDICGAGHCINLPVRYTCICYEGYRFS-EQQRKCVDIDECTQVQHLCSQGRC 606

Query: 444 FNTQGSFHCGCLPGWVLAPNGVSC 467
            NT+GSF C C  G++ +  G +C
Sbjct: 607 ENTEGSFLCICPAGFMASEEGTNC 630



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 77/318 (24%), Positives = 105/318 (33%), Gaps = 69/318 (21%)

Query: 275 CFEGGDGSFLCGCRPGFRLLDDLV----TCASRNPCSSSPCRGGATCVLGPHGKNYTCRC 330
           CF+   GS      PG    +D      T    N C   P +         HG N    C
Sbjct: 233 CFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSY------HGYNQMMEC 286

Query: 331 PQGYQLDSSQLDCVDVDECQ-DSPCAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDE 388
             GY+  ++   C D++ECQ    C   EC+NT G +RC C +G+ P         D   
Sbjct: 287 LPGYKRVNNTF-CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPV 345

Query: 389 CALGRSPCAQGCTNTDGSFH----------CSCEEGYVLAGEDGTQCQDVDECVGPGGPL 438
            +  + PC +  ++     H          C C  G       G  C   ++C  PG   
Sbjct: 346 ISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAW----GPHC---EKCPLPGTAA 398

Query: 439 CDSLCFNTQG------------SFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGPPDEE-- 484
              +C    G              H G  P +V   N         S  PP  P  EE  
Sbjct: 399 FKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAK---STHPPPLPAKEEPV 455

Query: 485 -----DKGEKEGSTVPRAATASP-----------TRGPEGTPKATPTTSRPSLSSDAP-- 526
                 +    G   P  ATA P           T+   G P+ +P  S   L    P  
Sbjct: 456 EALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQFPGI 515

Query: 527 ---ITSAPLKM-LAPSGS 540
               TS P+ + +AP  S
Sbjct: 516 VIEKTSPPVPVEVAPEAS 533



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 31/86 (36%), Positives = 43/86 (50%), Gaps = 6/86 (6%)

Query: 387  DECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC--VGPGGPLC-DSL 442
            +EC +  + C  G C      + C C +GY L     T C DV+EC  +     LC ++ 
Sbjct: 1298 EECGI-LNGCENGRCVRVQEGYTCDCFDGYHLDTAKMT-CVDVNECDELNNRMSLCKNAK 1355

Query: 443  CFNTQGSFHCGCLPGWVLAPNGVSCT 468
            C NT GS+ C CLPG+V +     CT
Sbjct: 1356 CINTDGSYKCLCLPGYVPSDKPNYCT 1381


>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score =  138 bits (347), Expect = 2e-32
 Identities = 70/150 (46%), Positives = 87/150 (58%), Gaps = 6/150 (4%)

Query: 321 PHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQ-ECVNTPGGFRCECWVGYEPGGPG 379
           P   +Y C C  GY+ D++  DC+DVDEC  +PC   +CVNTPG + C+C  G++   P 
Sbjct: 512 PTVSSYRCECNMGYKQDANG-DCIDVDECTSNPCTNGDCVNTPGSYYCKCHAGFQRT-PT 569

Query: 380 EGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPL 438
           + AC D+DEC      C  G C NTDGSF C C  G+ L   DG  C D DEC      L
Sbjct: 570 KQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELT-TDGKNCVDHDECTTTNMCL 628

Query: 439 CDSLCFNTQGSFHCGCLPGWVLAPNGVSCT 468
            + +C N  GSF C C PG+VLAPNG  CT
Sbjct: 629 -NGMCINEDGSFKCICKPGFVLAPNGRYCT 657



 Score =  135 bits (339), Expect = 2e-31
 Identities = 78/207 (37%), Positives = 106/207 (51%), Gaps = 17/207 (8%)

Query: 267  NNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATCVLGPHGK 324
            +N   H  C     GSF C CR G+  + + + C   + CS+    C   A CV  P   
Sbjct: 1376 HNCDMHASCLNI-PGSFKCSCREGW--IGNGIKCIDLDECSNGTHQCSINAQCVNTPG-- 1430

Query: 325  NYTCRCPQGYQLDSSQLDCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEG 381
            +Y C C +G+  D     C DVDEC ++   C   +C+N PG +RCEC +G+ P      
Sbjct: 1431 SYRCACSEGFTGDG--FTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSR- 1487

Query: 382  ACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCD 440
            +CQD+DEC+  ++ C  G C N  G FHC C++GY L    G  C D+DEC  P     +
Sbjct: 1488 SCQDIDECSF-QNICVFGTCNNLPGMFHCICDDGYEL-DRTGGNCTDIDECADPIN-CVN 1544

Query: 441  SLCFNTQGSFHCGCLPGWVLAPNGVSC 467
             LC NT G + C C P + L P GV C
Sbjct: 1545 GLCVNTPGRYECNCPPDFQLNPTGVGC 1571



 Score =  130 bits (327), Expect = 4e-30
 Identities = 76/211 (36%), Positives = 106/211 (50%), Gaps = 13/211 (6%)

Query: 264  CNFNNGGCHQDCFEGGDGSFLCGCRPGFRL-LDDLVTCASRNPCSSSP--CRGGATCVLG 320
            C  +   C         GSF C C  G+      +  C   + C  +P  CRGG TCV  
Sbjct: 1119 CRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGG-TCV-N 1176

Query: 321  PHGKNYTCRCPQGYQLDSSQLDCVDVDECQ--DSPCAQ-ECVNTPGGFRCECWVGYEPGG 377
              G ++ C CP G++L  S+ DCVD++EC   D+ C   +CVN  G ++C C  GY+   
Sbjct: 1177 TEG-SFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQ-AT 1234

Query: 378  PGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGP 437
            P    C D+DEC +    C   CTN++GS+ CSC EGY L   DG  C D+DEC      
Sbjct: 1235 PDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALM-PDGRSCADIDECEN-NPD 1292

Query: 438  LCD-SLCFNTQGSFHCGCLPGWVLAPNGVSC 467
            +CD   C N  G + C C  G++ + +  +C
Sbjct: 1293 ICDGGQCTNIPGEYRCLCYDGFMASMDMKTC 1323



 Score =  127 bits (320), Expect = 2e-29
 Identities = 76/191 (39%), Positives = 104/191 (54%), Gaps = 14/191 (7%)

Query: 282 SFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQL 341
           S+ C C  G++  D    C   + C+S+PC  G  CV  P   +Y C+C  G+Q   ++ 
Sbjct: 516 SYRCECNMGYKQ-DANGDCIDVDECTSNPCTNG-DCVNTP--GSYYCKCHAGFQRTPTKQ 571

Query: 342 DCVDVDEC-QDSPCAQ--ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQ 398
            C+D+DEC Q+    +   CVNT G F+C C  G+E    G+  C D DEC    + C  
Sbjct: 572 ACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKN-CVDHDECTT-TNMCLN 629

Query: 399 G-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC-DSLCFNTQGSFHCGCLP 456
           G C N DGSF C C+ G+VLA  +G  C DVDEC  PG  +C +  C N++GSF C C P
Sbjct: 630 GMCINEDGSFKCICKPGFVLA-PNGRYCTDVDECQTPG--ICMNGHCINSEGSFRCDCPP 686

Query: 457 GWVLAPNGVSC 467
           G  +  +G  C
Sbjct: 687 GLAVGMDGRVC 697



 Score =  124 bits (312), Expect = 2e-28
 Identities = 85/265 (32%), Positives = 114/265 (43%), Gaps = 63/265 (23%)

Query: 250  WGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTC-ASRNPCSS 308
            WG+    C  PK G       C +       G  L G RP ++   D+  C A    C+ 
Sbjct: 1033 WGTECEEC--PKPGTKEYETLCPRGAGFANRGDVLTG-RPFYK---DINECKAFPGMCTY 1086

Query: 309  SPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSP--CAQE-CVNTPGGF 365
              CR      +G    ++ CRC  G+ LD  + +C D+DEC+ SP  C    CVNTPG F
Sbjct: 1087 GKCRN----TIG----SFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSF 1138

Query: 366  RCECWVGYEPG------------------------------------------GPGEGAC 383
             CEC+ GYE G                                           P    C
Sbjct: 1139 ECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDC 1198

Query: 384  QDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSL 442
             D++EC+L  + C  G C N  G++ CSC  GY  A  D   C D+DEC+   G  CD+ 
Sbjct: 1199 VDINECSLSDNLCRNGKCVNMIGTYQCSCNPGY-QATPDRQGCTDIDECMIMNGG-CDTQ 1256

Query: 443  CFNTQGSFHCGCLPGWVLAPNGVSC 467
            C N++GS+ C C  G+ L P+G SC
Sbjct: 1257 CTNSEGSYECSCSEGYALMPDGRSC 1281



 Score =  120 bits (302), Expect = 3e-27
 Identities = 85/257 (33%), Positives = 110/257 (42%), Gaps = 28/257 (10%)

Query: 229  DKDETQSHYFLCKEKAPDVFDWGSSGPLC-----VSPKYGCNFNN------GGCHQDCFE 277
            D DE  +   LC+  A  +   GS    C     +SP   C   N        C      
Sbjct: 1850 DIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCV 1909

Query: 278  GGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATC--VLGPHGKNYTCRCPQGYQ 335
               GS+ C C  GF+   D   C   + C   PC G  TC   +G    +Y C C  G++
Sbjct: 1910 DLQGSYQCICHNGFKASQDQTMCMDVDECERHPC-GNGTCKNTVG----SYNCLCYPGFE 1964

Query: 336  LDSSQLDCVDVDECQD---SPCAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECAL 391
            L  +  DC+D+DEC       C    C N  G F+C C  GYE    G+  C D +EC  
Sbjct: 1965 LTHNN-DCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKN-CIDTNECVA 2022

Query: 392  GRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSF 450
                C+ G C N +GSF C C  GY +  E+   C D++EC           C NT G F
Sbjct: 2023 LPGSCSPGTCQNLEGSFRCICPPGYEVKSEN---CIDINECDEDPNICLFGSCTNTPGGF 2079

Query: 451  HCGCLPGWVLAPNGVSC 467
             C C PG+VL+ NG  C
Sbjct: 2080 QCLCPPGFVLSDNGRRC 2096



 Score =  120 bits (301), Expect = 4e-27
 Identities = 74/214 (34%), Positives = 106/214 (49%), Gaps = 20/214 (9%)

Query: 264  CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCS--SSPCRGGATCVLGP 321
            C+ N+  C     E   GSF+C C+ G+ +      C   + C   +  C   A+C+  P
Sbjct: 1329 CDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIP 1388

Query: 322  HGKNYTCRCPQGYQLDSSQLDCVDVDECQDSP--CA--QECVNTPGGFRCECWVGYEPGG 377
               ++ C C +G+    + + C+D+DEC +    C+   +CVNTPG +RC C  G+    
Sbjct: 1389 G--SFKCSCREGWI--GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT--- 1441

Query: 378  PGEG-ACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPG 435
             G+G  C DVDECA   + C  G C N  G++ C CE G+  A  D   CQD+DEC    
Sbjct: 1442 -GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPAS-DSRSCQDIDECSFQN 1499

Query: 436  GPLCD-SLCFNTQGSFHCGCLPGWVLAPNGVSCT 468
              +C    C N  G FHC C  G+ L   G +CT
Sbjct: 1500 --ICVFGTCNNLPGMFHCICDDGYELDRTGGNCT 1531



 Score =  120 bits (300), Expect = 5e-27
 Identities = 70/171 (40%), Positives = 88/171 (51%), Gaps = 14/171 (8%)

Query: 304  NPCSSSP--CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQ-DSPCAQ-ECV 359
            N C  SP  C  G    +   G ++ C CP GY LD + + CVD DEC   +PC    C 
Sbjct: 2173 NECLESPGICSNGQC--INTDG-SFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCT 2229

Query: 360  NTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAG 419
            N  G F C C  G+EPG      C+D++ECA     CA  C NT GS+ C+C  GY L  
Sbjct: 2230 NVIGSFECNCNEGFEPGPMMN--CEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALR- 2286

Query: 420  EDGTQCQDVDECVGPGGPLCDS---LCFNTQGSFHCGCLPGWVLAPNGVSC 467
            ED   C+D+DEC   G   C+S   +C N  G+F C C PG    P+G  C
Sbjct: 2287 EDQKMCKDLDEC-AEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC 2336



 Score =  120 bits (300), Expect = 5e-27
 Identities = 67/191 (35%), Positives = 92/191 (48%), Gaps = 7/191 (3%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQ 340
            G F C C PGF        C   N C S P   GA  +      +++C C +G+ LD++ 
Sbjct: 2552 GGFTCKCPPGFT--QHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATG 2609

Query: 341  LDCVDVDECQ-DSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG 399
            L+C DVDEC  +  C   C N  GG+RC C  GY         C D +EC+   +  +  
Sbjct: 2610 LNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQW-NQCVDENECSNPNACGSAS 2668

Query: 400  CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWV 459
            C NT GS+ C+C  G+    +  + C DV+EC     P C+  C NT+G + CGC PG+ 
Sbjct: 2669 CYNTLGSYKCACPSGFSF-DQFSSACHDVNECSSSKNP-CNYGCSNTEGGYLCGCPPGYY 2726

Query: 460  LAPNGVSCTMG 470
                G  C  G
Sbjct: 2727 RVGQG-HCVSG 2736



 Score =  119 bits (298), Expect = 9e-27
 Identities = 74/251 (29%), Positives = 102/251 (40%), Gaps = 54/251 (21%)

Query: 264  CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGAT----- 316
            C   NGGC   C    +GS+ C C  G+ L+ D  +CA  + C ++P  C GG       
Sbjct: 1246 CMIMNGGCDTQC-TNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPG 1304

Query: 317  -------------------------------CVLGPHGK---NYTCRCPQGYQLDSSQLD 342
                                           C+ G       ++ C C  GY +      
Sbjct: 1305 EYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTG 1364

Query: 343  CVDVDECQ----DSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCA- 397
            C DVDEC+    +      C+N PG F+C C  G+   G     C D+DEC+ G   C+ 
Sbjct: 1365 CTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGI---KCIDLDECSNGTHQCSI 1421

Query: 398  -QGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLP 456
               C NT GS+ C+C EG+     DG  C DVDEC        +  C N  G++ C C  
Sbjct: 1422 NAQCVNTPGSYRCACSEGFT---GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEM 1478

Query: 457  GWVLAPNGVSC 467
            G+  A +  SC
Sbjct: 1479 GFTPASDSRSC 1489



 Score =  115 bits (289), Expect = 1e-25
 Identities = 89/246 (36%), Positives = 114/246 (46%), Gaps = 29/246 (11%)

Query: 226  GEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCN--FNNGGCHQDCFEGGDGSF 283
            GEG  DE +     C+ K P + + G    +  S +  CN  F +     +C +   G  
Sbjct: 2333 GEGCVDENE-----CRTK-PGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQG-- 2384

Query: 284  LCGCRPGFRLLDDLVTCASRNPCSSSPC-----RG-GATCVLGP--HGKNYTCRCPQGYQ 335
            LC       +    +  +SRN  + S C     RG G  C L P      Y   CP G  
Sbjct: 2385 LCFAEVLQTICQ--MASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHG-- 2440

Query: 336  LDSSQLDCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALG 392
                  D  D+DEC+  P  C   +C+NT G FRC C VGY     G  +C D+DEC+  
Sbjct: 2441 -PGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGT-SCIDLDECSQS 2498

Query: 393  RSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHC 452
              PC   C NT+GS+ CSC  GYVL  EDG  C+D+DEC       C  LC NT G F C
Sbjct: 2499 PKPCNYICKNTEGSYQCSCPRGYVLQ-EDGKTCKDLDECQTKQHN-CQFLCVNTLGGFTC 2556

Query: 453  GCLPGW 458
             C PG+
Sbjct: 2557 KCPPGF 2562



 Score =  113 bits (283), Expect = 5e-25
 Identities = 73/215 (33%), Positives = 103/215 (47%), Gaps = 25/215 (11%)

Query: 264  CNFNNGGCH----QDCFEGGDGSF--LCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGA 315
            C +N G       + C   G   F  +CG  PGF            + C   P  C  G 
Sbjct: 1764 CTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGV 1823

Query: 316  TCV--LGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQ--DSPCAQ--ECVNTPGGFRCEC 369
             C+  +G    ++ C CP G+  +   L C D+DEC   D+ C +  +C+N+PG +RCEC
Sbjct: 1824 -CINQIG----SFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCEC 1878

Query: 370  WVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDV 428
              G++      GAC D +EC    + C+ G C +  GS+ C C  G+  A +D T C DV
Sbjct: 1879 AAGFKLS--PNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGF-KASQDQTMCMDV 1935

Query: 429  DECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPN 463
            DEC     P  +  C NT GS++C C PG+ L  N
Sbjct: 1936 DEC--ERHPCGNGTCKNTVGSYNCLCYPGFELTHN 1968



 Score =  112 bits (280), Expect = 1e-24
 Identities = 71/212 (33%), Positives = 100/212 (47%), Gaps = 16/212 (7%)

Query: 264  CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCS-SSPCRGGATC--VLG 320
            C  + G C        DGSF C C  G+ L    V C   + CS  +PC G  TC  V+G
Sbjct: 2175 CLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPC-GNGTCTNVIG 2233

Query: 321  PHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSP--CAQECVNTPGGFRCECWVGYEPGGP 378
                ++ C C +G++     ++C D++EC  +P  CA  C+NT G + C C +GY     
Sbjct: 2234 ----SFECNCNEGFE-PGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYAL-RE 2287

Query: 379  GEGACQDVDECALGRSPC---AQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPG 435
             +  C+D+DECA G   C      C N  G+F C C  G +    DG  C D +EC    
Sbjct: 2288 DQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPG-MARRPDGEGCVDENECRTKP 2346

Query: 436  GPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
            G   +  C N  GS+ C C  G+  + +G  C
Sbjct: 2347 GICENGRCVNIIGSYRCECNEGFQSSSSGTEC 2378



 Score =  103 bits (256), Expect = 6e-22
 Identities = 73/220 (33%), Positives = 102/220 (46%), Gaps = 39/220 (17%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATC-VLGPHGKNYTCRCPQGYQLD 337
            G+F+C C PG     D   C   N C + P  C  G    ++G    +Y C C +G+Q  
Sbjct: 2317 GTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIG----SYRCECNEGFQSS 2372

Query: 338  SSQLDCVDVDE-----------CQDSPCAQ------ECVNTPG---GFRCECW-----VG 372
            SS  +C+D  +           CQ +  ++      EC    G   G +CE         
Sbjct: 2373 SSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQ 2432

Query: 373  YE---PGGPGEGAC-QDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQD 427
            Y+   P GPG     +D+DEC +  + C  G C NT GSF C C+ GY      GT C D
Sbjct: 2433 YKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYT-TDISGTSCID 2491

Query: 428  VDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
            +DEC     P C+ +C NT+GS+ C C  G+VL  +G +C
Sbjct: 2492 LDECSQSPKP-CNYICKNTEGSYQCSCPRGYVLQEDGKTC 2530



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 71/255 (27%), Positives = 101/255 (39%), Gaps = 48/255 (18%)

Query: 262  YGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATCVL 319
            +G    NG C  +      GSF C C  G+ L  D   C   N C + P  C  G    L
Sbjct: 1981 FGQVCRNGRCFNEI-----GSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNL 2035

Query: 320  GPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSP---CAQECVNTPGGFRCECWVGYEPG 376
                 ++ C CP GY++ S   +C+D++EC + P       C NTPGGF+C C  G+   
Sbjct: 2036 EG---SFRCICPPGYEVKSE--NCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLS 2090

Query: 377  GPGEGACQDVDE-----------CALGRS--------------------PCAQGCTNTDG 405
              G   C D  +           C++ ++                    PC     + + 
Sbjct: 2091 DNGR-RCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEV 2149

Query: 406  SFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGV 465
            +F   C  G+          +DV+EC+   G   +  C NT GSF C C  G+ L   GV
Sbjct: 2150 AFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGV 2209

Query: 466  SCT-MGPVSLGPPSG 479
             C      S+G P G
Sbjct: 2210 RCVDTDECSIGNPCG 2224



 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 72/267 (26%), Positives = 96/267 (35%), Gaps = 84/267 (31%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQ 340
            G++ C C  GF    D  +C   + CS        TC   P    + C C  GY+LD + 
Sbjct: 1470 GAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPG--MFHCICDDGYELDRTG 1527

Query: 341  LDCVDVDECQD-----------SPCAQECVNTPGGFR----------------------- 366
             +C D+DEC D           +P   EC N P  F+                       
Sbjct: 1528 GNCTDIDECADPINCVNGLCVNTPGRYEC-NCPPDFQLNPTGVGCVDNRVGNCYLKFGPR 1586

Query: 367  -------------------CECWVGYEPGGP------------------GEG-------- 381
                               C C +G   G P                  GEG        
Sbjct: 1587 GDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITI 1646

Query: 382  ACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCD 440
              +D+DEC      C  G C NT GSF C C +GY L+ ED   C+D+DEC    G    
Sbjct: 1647 ILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLS-EDTRICEDIDECFAHPGVCGP 1705

Query: 441  SLCFNTQGSFHCGCLPGWVLAPNGVSC 467
              C+NT G++ C C P ++    G +C
Sbjct: 1706 GTCYNTLGNYTCICPPEYMQVNGGHNC 1732



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 66/233 (28%), Positives = 93/233 (39%), Gaps = 38/233 (16%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGF------RLLDDLVTC-ASRNPCSSSPCRGGAT 316
           C  +   C     E   GS+ C C  G+      R   D+  C  +R  C +  CR    
Sbjct: 772 CALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPG 831

Query: 317 CVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQ-ECVNTPGGFRCECWVGYEP 375
                   +Y+C CP GY   +    C D++EC+ +PC    C N  G F CEC  G + 
Sbjct: 832 --------SYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKL 883

Query: 376 GGPG-------EGAC----QDVDECAL---GRSPCAQGCTNTDGSFHCSCEEGYV----- 416
              G       +G C    QD   C +   G +  ++ C     ++   CE   +     
Sbjct: 884 SSTGLICIDSLKGTCWLNIQD-SRCEVNINGATLKSECCATLGAAWGSPCERCELDTACP 942

Query: 417 --LAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
             LA   G  C+DV+EC    G   +  C N++GSFHC C  G  L   G  C
Sbjct: 943 RGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVC 995



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 83/326 (25%), Positives = 110/326 (33%), Gaps = 102/326 (31%)

Query: 225 CGEGDKDETQSHYFL----------CKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQD 274
           C  GD   T   Y+            K+   D+ +   +G LC          NG C   
Sbjct: 544 CTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLC---------KNGRCVNT 594

Query: 275 CFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGY 334
                DGSF C C  GF L  D   C   + C+++       C+      ++ C C  G+
Sbjct: 595 -----DGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCI--NEDGSFKCICKPGF 647

Query: 335 QLDSSQLDCVDVDECQDSPCAQ--ECVNTPGGFRCECWVGYEPGGPG------------- 379
            L  +   C DVDECQ         C+N+ G FRC+C  G   G  G             
Sbjct: 648 VLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCY 707

Query: 380 ----EGACQDVDECALGRSPCAQGCTNTD---------------GSFH--CSCEEGYVLA 418
               +G C      A+ +S C   C N D                 FH  CS   G  + 
Sbjct: 708 GGIKKGVCVRPFPGAVTKSECC--CANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVD 765

Query: 419 GED------------------------------------GTQCQDVDECVGPGGPLCDS- 441
           G D                                    G  C D+DEC+     LCD+ 
Sbjct: 766 GRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL-VNRLLCDNG 824

Query: 442 LCFNTQGSFHCGCLPGWVLAPNGVSC 467
           LC NT GS+ C C PG+V      +C
Sbjct: 825 LCRNTPGSYSCTCPPGYVFRTETETC 850



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 68/202 (33%), Positives = 87/202 (43%), Gaps = 47/202 (23%)

Query: 298  VTCASRNPCSSSP--CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDV--DECQDSP 353
            VTC   N C   P  C  G  CV      ++ C CP+G  LD +   C+D+  ++C    
Sbjct: 951  VTCEDVNECEVFPGVCPNGR-CVNSKG--SFHCECPEGLTLDGTGRVCLDIRMEQCYLKW 1007

Query: 354  CAQECVN-TPGGFR---CECWVG-----------------YE---PGG----------PG 379
               EC++  PG FR   C C VG                 YE   P G           G
Sbjct: 1008 DEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTG 1067

Query: 380  EGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC-VGPGGP 437
                +D++EC      C  G C NT GSF C C  G+ L  E+   C D+DEC + P   
Sbjct: 1068 RPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEE-RNCTDIDECRISP--D 1124

Query: 438  LCDS-LCFNTQGSFHCGCLPGW 458
            LC S +C NT GSF C C  G+
Sbjct: 1125 LCGSGICVNTPGSFECECFEGY 1146



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 68/225 (30%), Positives = 92/225 (40%), Gaps = 43/225 (19%)

Query: 271 CHQDCFEGGD-GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCR 329
           C   C  GG      C C+ G+      +      P   + C+ G  C+ GP+     C 
Sbjct: 149 CSVRCMNGGTCADDHCQCQKGY------IGTYCGQPVCENGCQNGGRCI-GPN----RCA 197

Query: 330 CPQGYQLDSSQLDC--------VDVDECQDSPCAQECVNT--------PGGFRCE----- 368
           C  G+     + D         V+   CQ       C  T          G  CE     
Sbjct: 198 CVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257

Query: 369 ---CWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQ 424
              C  G+ P     GACQDVDEC      C  G C NT GSF C C  G+  + E   +
Sbjct: 258 PQPCRRGFIPN-IRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQS-ETTQK 315

Query: 425 CQDVDEC-VGPGGPLCDS-LCFNTQGSFHCGCLPGWVLAPNGVSC 467
           C+D+DEC + PG  +C++  C NT GS+ C C  G+V + +G  C
Sbjct: 316 CEDIDECSIIPG--ICETGECSNTVGSYFCVCPRGYVTSTDGSRC 358



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 58/213 (27%), Positives = 74/213 (34%), Gaps = 43/213 (20%)

Query: 284  LCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATCVLGPHGKNYTCRCPQGYQLDSSQL 341
            LC    GFR     +     + C   P  C+GG  C+    G ++ C CPQGY L     
Sbjct: 1632 LCPGGEGFRPNPITIILEDIDECQELPGLCQGG-NCI-NTFG-SFQCECPQGYYLSEDTR 1688

Query: 342  DCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRS---- 394
             C D+DEC   P  C    C NT G + C C   Y     G   C D+ +    RS    
Sbjct: 1689 ICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHN-CMDMRKSFCYRSYNGT 1747

Query: 395  ---------------------------PCAQGCTNTDGSFHCSCEE--GYVLAGEDGTQC 425
                                       PC    T     F   C    G+      G + 
Sbjct: 1748 TCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTG-KA 1806

Query: 426  QDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGW 458
             D+DEC    G   + +C N  GSF C C  G+
Sbjct: 1807 VDIDECKEIPGICANGVCINQIGSFRCECPTGF 1839



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 44/138 (31%), Positives = 56/138 (40%), Gaps = 15/138 (10%)

Query: 287 CRPGFRLLDDLVTCASRNPCSSSP--CRGGATCV--LGPHGKNYTCRCPQGYQLDSSQLD 342
           CR GF        C   + C + P  C+GG  C+  +G    ++ CRCP G++   +   
Sbjct: 261 CRRGFIPNIRTGACQDVDECQAIPGICQGG-NCINTVG----SFECRCPAGHKQSETTQK 315

Query: 343 CVDVDECQDSP--C-AQECVNTPGGFRCECWVGYEPGGPGEGAC-QDVDECALG--RSPC 396
           C D+DEC   P  C   EC NT G + C C  GY     G     Q    C  G     C
Sbjct: 316 CEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRC 375

Query: 397 AQGCTNTDGSFHCSCEEG 414
           AQ          C CE G
Sbjct: 376 AQELPGRMTKMQCCCEPG 393



 Score = 30.4 bits (67), Expect = 5.3
 Identities = 19/68 (27%), Positives = 26/68 (38%), Gaps = 5/68 (7%)

Query: 224  ACGEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSF 283
            ACG      T   Y   K   P  F +      C      C+ +   C+  C    +G +
Sbjct: 2663 ACGSASCYNTLGSY---KCACPSGFSFDQFSSACHDVNE-CSSSKNPCNYGC-SNTEGGY 2717

Query: 284  LCGCRPGF 291
            LCGC PG+
Sbjct: 2718 LCGCPPGY 2725


>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
          Length = 993

 Score =  138 bits (347), Expect = 2e-32
 Identities = 89/216 (41%), Positives = 104/216 (48%), Gaps = 23/216 (10%)

Query: 261 KYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDD----LVTCASRNPCSSSPCRGGAT 316
           K  CN+ NGGC   C +   G   CGC   F L  D    + TCA  N    S C   AT
Sbjct: 198 KLTCNYGNGGCQHTCDDTEQGP-RCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAAT 256

Query: 317 CVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQ--DSPCAQECVNTPGGFRCECWVGYE 374
              G H     C CP G+ L   +  C D+DEC+  +  C   C NT G F C C  GY+
Sbjct: 257 ---GVH-----CTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYK 308

Query: 375 PGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC-VG 433
                E  CQD+DEC+  R+ C   C NT GSF C C  GY+L G   T C DVDEC + 
Sbjct: 309 LL-INERNCQDIDECSFDRT-CDHICVNTPGSFQCLCHRGYLLYGI--THCGDVDECSIN 364

Query: 434 PGGPLCDSLCFNTQGSFHCGCLPG-WVLAPNGVSCT 468
            GG  C   C NT GS+ C C  G   L  NG  CT
Sbjct: 365 RGG--CRFGCINTPGSYQCTCPAGQGRLHWNGKDCT 398



 Score =  123 bits (309), Expect = 5e-28
 Identities = 89/283 (31%), Positives = 116/283 (40%), Gaps = 29/283 (10%)

Query: 176 EGFVCKFSFKG---MCRPLALGG------PGQVTYTTPFQTTSSSLEAVPFASAANVACG 226
           EG  C     G   +CR    GG      PG       F+ T +  +     +  N  C 
Sbjct: 157 EGMNCMNKNHGCAHICRETPKGGIACECRPG-------FELTKNQRDCKLTCNYGNGGCQ 209

Query: 227 EGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCG 286
               D  Q     C  K    F   + G  C+     C  NNGGC   C +   G   C 
Sbjct: 210 HTCDDTEQGPRCGCHIK----FVLHTDGKTCIET---CAVNNGGCDSKCHDAATGVH-CT 261

Query: 287 CRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDV 346
           C  GF L  D  TC   + C  +   GG   +      ++ C C +GY+L  ++ +C D+
Sbjct: 262 CPVGFMLQPDRKTCKDIDECRLN--NGGCDHICRNTVGSFECSCKKGYKLLINERNCQDI 319

Query: 347 DECQ-DSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDG 405
           DEC  D  C   CVNTPG F+C C  GY   G     C DVDEC++ R  C  GC NT G
Sbjct: 320 DECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITH--CGDVDECSINRGGCRFGCINTPG 377

Query: 406 SFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQG 448
           S+ C+C  G      +G  C +  +C G  G     L  N  G
Sbjct: 378 SYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSG 420



 Score =  116 bits (291), Expect = 6e-26
 Identities = 68/197 (34%), Positives = 88/197 (44%), Gaps = 8/197 (4%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHG 323
           C   N GC   C E   G   C CRPGF L  +   C       +  C+   TC     G
Sbjct: 161 CMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQH--TCDDTEQG 218

Query: 324 KNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGAC 383
               C C   + L +    C++     +  C  +C +   G  C C VG+    P    C
Sbjct: 219 PR--CGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQ-PDRKTC 275

Query: 384 QDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLC 443
           +D+DEC L    C   C NT GSF CSC++GY L   +   CQD+DEC       CD +C
Sbjct: 276 KDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINE-RNCQDIDEC--SFDRTCDHIC 332

Query: 444 FNTQGSFHCGCLPGWVL 460
            NT GSF C C  G++L
Sbjct: 333 VNTPGSFQCLCHRGYLL 349



 Score =  111 bits (277), Expect = 2e-24
 Identities = 70/215 (32%), Positives = 96/215 (44%), Gaps = 25/215 (11%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHG 323
           C   NGGC Q C     GS+ C CR GF L D+  TC  R          G  C+   HG
Sbjct: 116 CAEGNGGCQQSCVNMM-GSYECHCREGFFLSDNQHTCIQRP-------EEGMNCMNKNHG 167

Query: 324 KNYTCR----------CPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGY 373
             + CR          C  G++L  +Q DC       +  C   C +T  G RC C + +
Sbjct: 168 CAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKF 227

Query: 374 EPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC-V 432
                G+     ++ CA+    C   C +     HC+C  G++L  +  T C+D+DEC +
Sbjct: 228 VLHTDGKTC---IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKT-CKDIDECRL 283

Query: 433 GPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
             GG  CD +C NT GSF C C  G+ L  N  +C
Sbjct: 284 NNGG--CDHICRNTVGSFECSCKKGYKLLINERNC 316



 Score =  107 bits (266), Expect = 4e-23
 Identities = 61/166 (36%), Positives = 79/166 (47%), Gaps = 13/166 (7%)

Query: 311 CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQ---DSPCAQECVNTPGGFRC 367
           C   A C   P  ++Y C C  GY  D     C DVDEC+   ++ C  +CVN PG +RC
Sbjct: 40  CHIDAICQNTP--RSYKCICKSGYTGDGKH--CKDVDECEREDNAGCVHDCVNIPGNYRC 95

Query: 368 ECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQD 427
            C+ G+     G   C DVDECA G   C Q C N  GS+ C C EG+ L+    T  Q 
Sbjct: 96  TCYDGFHLAHDGHN-CLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQR 154

Query: 428 VDE---CVGPGGPLCDSLCFNT-QGSFHCGCLPGWVLAPNGVSCTM 469
            +E   C+      C  +C  T +G   C C PG+ L  N   C +
Sbjct: 155 PEEGMNCMNKNHG-CAHICRETPKGGIACECRPGFELTKNQRDCKL 199



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 53/133 (39%), Positives = 68/133 (51%), Gaps = 12/133 (9%)

Query: 345 DVDECQDSP--CAQE--CVNTPGGFRCECWVGYEPGGPGEGACQDVDECAL-GRSPCAQG 399
           DVDEC +    C  +  C NTP  ++C C  GY   G     C+DVDEC     + C   
Sbjct: 29  DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKH---CKDVDECEREDNAGCVHD 85

Query: 400 CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECV-GPGGPLCDSLCFNTQGSFHCGCLPGW 458
           C N  G++ C+C +G+ LA  DG  C DVDEC  G GG  C   C N  GS+ C C  G+
Sbjct: 86  CVNIPGNYRCTCYDGFHLA-HDGHNCLDVDECAEGNGG--CQQSCVNMMGSYECHCREGF 142

Query: 459 VLAPNGVSCTMGP 471
            L+ N  +C   P
Sbjct: 143 FLSDNQHTCIQRP 155



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 36/88 (40%), Positives = 44/88 (50%), Gaps = 5/88 (5%)

Query: 382 ACQDVDECALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC 439
           A QDVDEC  G   C     C NT  S+ C C+ GY     DG  C+DVDEC       C
Sbjct: 26  AAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT---GDGKHCKDVDECEREDNAGC 82

Query: 440 DSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
              C N  G++ C C  G+ LA +G +C
Sbjct: 83  VHDCVNIPGNYRCTCYDGFHLAHDGHNC 110


>gi|194328809 latent transforming growth factor beta binding protein
           3 isoform 1 [Homo sapiens]
          Length = 1303

 Score =  137 bits (345), Expect = 3e-32
 Identities = 87/202 (43%), Positives = 111/202 (54%), Gaps = 18/202 (8%)

Query: 275 CFEGGDGSFLCGCRPGFRLLDDLV--TCASRNPCSSSP-CRGGATCVLGPHGKNYTCRCP 331
           C   G GS+ C C  G+RL       +C   N C+    C  G  C+  P   +Y C C 
Sbjct: 632 CMNTG-GSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPG--HYKCNCY 688

Query: 332 QGYQLDSSQLD-CVDVDECQD-SPCAQ-ECVNTPGGFRC-ECWVGYEPGGPGEGACQDVD 387
            GY+L +S+   C D+DEC+D S C   +C N PG F+C  C  GY     G GAC+DV+
Sbjct: 689 PGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR--SQGGGACRDVN 746

Query: 388 ECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS-LCFN 445
           ECA G SPC+ G C N  GSF C+C +GY  A  DG  C DVDEC    G +CD+ +C N
Sbjct: 747 ECAEG-SPCSPGWCENLPGSFRCTCAQGYAPA-PDGRSCLDVDEC--EAGDVCDNGICSN 802

Query: 446 TQGSFHCGCLPGWVLAPNGVSC 467
           T GSF C CL G+ L+ +   C
Sbjct: 803 TPGSFQCQCLSGYHLSRDRSHC 824



 Score =  117 bits (294), Expect = 3e-26
 Identities = 71/206 (34%), Positives = 93/206 (45%), Gaps = 20/206 (9%)

Query: 271 CHQDCFEGGDGSFLC-GCRPGFR-----LLDDLVTCASRNPCSSSPCRGGATCVLGPHGK 324
           C     E   GSF C  C+PG+R        D+  CA  +PCS   C             
Sbjct: 713 CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPG-------- 764

Query: 325 NYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQE--CVNTPGGFRCECWVGYEPGGPGEGA 382
           ++ C C QGY        C+DVDEC+         C NTPG F+C+C  GY         
Sbjct: 765 SFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRD-RSH 823

Query: 383 CQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC-VGPGGPLCDS 441
           C+D+DEC    +     C NT+GS+ C C +G+ L G  G +CQD+DEC   P   L   
Sbjct: 824 CEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVG--GRKCQDIDECSQDPSLCLPHG 881

Query: 442 LCFNTQGSFHCGCLPGWVLAPNGVSC 467
            C N QGS+ C C  G+    +   C
Sbjct: 882 ACKNLQGSYVCVCDEGFTPTQDQHGC 907



 Score =  116 bits (290), Expect = 7e-26
 Identities = 98/302 (32%), Positives = 129/302 (42%), Gaps = 55/302 (18%)

Query: 196 PGQVTYTTPFQTTSSSL---EAVPFASAANVACGEGDKDETQSHYFLCKEKAPDVFDWGS 252
           P QVT T   +   +     E VP     +  C  G +   Q  Y +   +  +    G 
Sbjct: 569 PTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNEC-EAEPCGP 627

Query: 253 SGPLCVSP--KYGCNFNNG----------------GCHQD--CFEGG-----DGSFLCGC 287
              +C++    Y C+ N G                 C +   C +GG      G + C C
Sbjct: 628 GRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNC 687

Query: 288 RPGFRLLDDLVTCASRNPCSSS--PCRGGATCVLGPHGK------NYTC-RCPQGYQLDS 338
            PG+RL       ASR P       CR  ++C   P GK      ++ C  C  GY+   
Sbjct: 688 YPGYRLK------ASRPPVCEDIDECRDPSSC---PDGKCENKPGSFKCIACQPGYRSQG 738

Query: 339 SQLDCVDVDECQD-SPCAQE-CVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPC 396
               C DV+EC + SPC+   C N PG FRC C  GY P   G  +C DVDEC  G   C
Sbjct: 739 GGA-CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGR-SCLDVDECEAG-DVC 795

Query: 397 AQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCL 455
             G C+NT GSF C C  GY L+  D + C+D+DEC  P   +    C NT GS+ C C 
Sbjct: 796 DNGICSNTPGSFQCQCLSGYHLS-RDRSHCEDIDECDFPAACIGGD-CINTNGSYRCLCP 853

Query: 456 PG 457
            G
Sbjct: 854 QG 855



 Score =  105 bits (261), Expect = 2e-22
 Identities = 63/175 (36%), Positives = 80/175 (45%), Gaps = 11/175 (6%)

Query: 313 GGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQE---CVNTPGGFRCEC 369
           G   CV GP   +Y+C C  GY+       CVDV+EC+  PC      C+NT G + C C
Sbjct: 586 GHGECVPGP--PDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHC 643

Query: 370 WVGYE-PGGPGEGACQDVDECALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDGTQCQ 426
             GY    G G  +C D++ECA     C  G  C N  G + C+C  GY L       C+
Sbjct: 644 NRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPGHYKCNCYPGYRLKASRPPVCE 702

Query: 427 DVDECVGPGGPLCDSLCFNTQGSFHC-GCLPGWVLAPNGVSCTMGPVSLGPPSGP 480
           D+DEC  P     D  C N  GSF C  C PG+     G    +   + G P  P
Sbjct: 703 DIDECRDPSS-CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSP 756



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 60/192 (31%), Positives = 88/192 (45%), Gaps = 24/192 (12%)

Query: 257 CVSPKYGCNFNNGGCHQD---CFEGGD----------GSFLCGCRPGFRLLDDLVTCASR 303
           C++ + G     GG  +D   C EG            GSF C C  G+    D  +C   
Sbjct: 727 CIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV 786

Query: 304 NPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCA---QECVN 360
           + C +        C   P   ++ C+C  GY L   +  C D+DEC D P A    +C+N
Sbjct: 787 DECEAGDVCDNGICSNTPG--SFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDCIN 843

Query: 361 TPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQ--GCTNTDGSFHCSCEEGYVLA 418
           T G +RC C  G+   G  +  CQD+DEC+   S C     C N  GS+ C C+EG+   
Sbjct: 844 TNGSYRCLCPQGHRLVGGRK--CQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFT-P 900

Query: 419 GEDGTQCQDVDE 430
            +D   C++V++
Sbjct: 901 TQDQHGCEEVEQ 912



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 62/173 (35%), Positives = 77/173 (44%), Gaps = 17/173 (9%)

Query: 308  SSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQD-SPCAQ-ECVNTPGGF 365
            S  C+ G  CV    G  Y C C QG+  D + L+CVDVDEC D S C    C NT GG+
Sbjct: 1002 SEICKEGK-CVNTQPG--YECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGY 1058

Query: 366  RCECWVGYEPGGPGEGAC-----QDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAG 419
            RC C    E   P +  C      DVDEC    + C  G C N  GS+ C C   +V  G
Sbjct: 1059 RCACTPPAE-YSPAQRQCLSPEEMDVDECQ-DPAACRPGRCVNLPGSYRCECRPPWV-PG 1115

Query: 420  EDGTQCQDVDECVGPGGPLCDSLCFNTQG--SFHCGCLPGWVLAPNGVSCTMG 470
              G  CQ + E      P    +C++ +G      G L G  L  +   C  G
Sbjct: 1116 PSGRDCQ-LPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQG 1167



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 71/236 (30%), Positives = 91/236 (38%), Gaps = 39/236 (16%)

Query: 285  CGCRPGFRLLDDLVTCASRNPC-SSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDC 343
            C C+ GF    +L+ C   + C   S CR G   V       Y C C    +   +Q  C
Sbjct: 1019 CYCKQGFYYDGNLLECVDVDECLDESNCRNG---VCENTRGGYRCACTPPAEYSPAQRQC 1075

Query: 344  -----VDVDECQDSPCAQ--ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPC 396
                 +DVDECQD    +   CVN PG +RCEC   + PG  G        +C L  SP 
Sbjct: 1076 LSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGR-------DCQLPESPA 1128

Query: 397  AQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECV---GPG-GPLCDSLCFNTQGSFHC 452
             +     D  +    E+G + AG         D+C    G G G  C        GS HC
Sbjct: 1129 ERAPERRDVCWSQRGEDG-MCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGS-HC 1186

Query: 453  GCLPGWVLAPNGVSCTMGPVSLGPPSGPPDEEDKGEKE--------GSTVPRAATA 500
               P      N    T  P+ LG    PP +ED  E++        G  VPR   A
Sbjct: 1187 ---PTSQSESNSFWDT-SPLLLGK---PPRDEDSSEEDSDECRCVSGRCVPRPGGA 1235



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 37/83 (44%), Positives = 44/83 (53%), Gaps = 10/83 (12%)

Query: 308  SSPCRG-GATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSP-----CAQE-CVN 360
            S  CR     CV  P G    C CP G+QLD+S+  CVD+DEC++       C  E CVN
Sbjct: 1218 SDECRCVSGRCVPRPGGA--VCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVN 1275

Query: 361  TPGGFRCECWVGYEPGGPGEGAC 383
            T G FRC C  G+    P  GAC
Sbjct: 1276 TSGSFRCVCKAGFARSRP-HGAC 1297



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 30/83 (36%), Positives = 39/83 (46%), Gaps = 9/83 (10%)

Query: 345  DVDECQDSPCAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECA----LGRSPCAQG 399
            D DEC+   C    CV  PGG  CEC  G++        C D+DEC      G    ++ 
Sbjct: 1217 DSDECR---CVSGRCVPRPGGAVCECPGGFQLDA-SRARCVDIDECRELNQRGLLCKSER 1272

Query: 400  CTNTDGSFHCSCEEGYVLAGEDG 422
            C NT GSF C C+ G+  +   G
Sbjct: 1273 CVNTSGSFRCVCKAGFARSRPHG 1295



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 32/86 (37%), Positives = 40/86 (46%), Gaps = 11/86 (12%)

Query: 384  QDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC--VGPGGPLCD 440
            +D DEC      C  G C    G   C C  G+ L      +C D+DEC  +   G LC 
Sbjct: 1216 EDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRA-RCVDIDECRELNQRGLLCK 1269

Query: 441  S-LCFNTQGSFHCGCLPGWVLA-PNG 464
            S  C NT GSF C C  G+  + P+G
Sbjct: 1270 SERCVNTSGSFRCVCKAGFARSRPHG 1295



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 5/64 (7%)

Query: 405 GSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC-DSLCFNTQGSFHCGCLPGWVLAPN 463
           G     C +GY     + T CQD++EC  PG  +C    C N  GS+ C C PG  L P+
Sbjct: 335 GEVGADCPQGYKRL--NSTHCQDINECAMPG--VCRHGDCLNNPGSYRCVCPPGHSLGPS 390

Query: 464 GVSC 467
              C
Sbjct: 391 RTQC 394



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 59/221 (26%), Positives = 80/221 (36%), Gaps = 34/221 (15%)

Query: 320 GPHGKNYTCRCPQGYQLDSSQLDCVDVDEC-QDSPCAQ-ECVNTPGGFRCECWVGYEPGG 377
           GP        CPQGY+  +S   C D++EC     C   +C+N PG +RC C  G+   G
Sbjct: 331 GPVRGEVGADCPQGYKRLNST-HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL-G 388

Query: 378 PGEGAC-----QDVDECALGRSP---CAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVD 429
           P    C     ++   C    SP   C    T       C C  G       G +CQ   
Sbjct: 389 PSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAW----GARCQ--- 441

Query: 430 ECVGPGGPLCDSLC-----FNTQGSFHCGCLPG-----WVLAPNGVSCTMGPVSL-GPPS 478
            C   G      +C     ++   S     + G       L P+G      P  L   PS
Sbjct: 442 RCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDG---PPKPQQLPESPS 498

Query: 479 GPPDEEDKGEKEGSTVPRAATASPTRGPEGTPKATPTTSRP 519
             P  ED  E+ G T   +  +      +  P AT T +RP
Sbjct: 499 QAPPPEDTEEERGVTTD-SPVSEERSVQQSHPTATTTPARP 538


>gi|18497288 latent transforming growth factor beta binding protein
           3 isoform 2 [Homo sapiens]
          Length = 1256

 Score =  137 bits (345), Expect = 3e-32
 Identities = 87/202 (43%), Positives = 111/202 (54%), Gaps = 18/202 (8%)

Query: 275 CFEGGDGSFLCGCRPGFRLLDDLV--TCASRNPCSSSP-CRGGATCVLGPHGKNYTCRCP 331
           C   G GS+ C C  G+RL       +C   N C+    C  G  C+  P   +Y C C 
Sbjct: 632 CMNTG-GSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPG--HYKCNCY 688

Query: 332 QGYQLDSSQLD-CVDVDECQD-SPCAQ-ECVNTPGGFRC-ECWVGYEPGGPGEGACQDVD 387
            GY+L +S+   C D+DEC+D S C   +C N PG F+C  C  GY     G GAC+DV+
Sbjct: 689 PGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR--SQGGGACRDVN 746

Query: 388 ECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS-LCFN 445
           ECA G SPC+ G C N  GSF C+C +GY  A  DG  C DVDEC    G +CD+ +C N
Sbjct: 747 ECAEG-SPCSPGWCENLPGSFRCTCAQGYAPA-PDGRSCLDVDEC--EAGDVCDNGICSN 802

Query: 446 TQGSFHCGCLPGWVLAPNGVSC 467
           T GSF C CL G+ L+ +   C
Sbjct: 803 TPGSFQCQCLSGYHLSRDRSHC 824



 Score =  117 bits (294), Expect = 3e-26
 Identities = 71/206 (34%), Positives = 93/206 (45%), Gaps = 20/206 (9%)

Query: 271 CHQDCFEGGDGSFLC-GCRPGFR-----LLDDLVTCASRNPCSSSPCRGGATCVLGPHGK 324
           C     E   GSF C  C+PG+R        D+  CA  +PCS   C             
Sbjct: 713 CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPG-------- 764

Query: 325 NYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQE--CVNTPGGFRCECWVGYEPGGPGEGA 382
           ++ C C QGY        C+DVDEC+         C NTPG F+C+C  GY         
Sbjct: 765 SFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRD-RSH 823

Query: 383 CQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC-VGPGGPLCDS 441
           C+D+DEC    +     C NT+GS+ C C +G+ L G  G +CQD+DEC   P   L   
Sbjct: 824 CEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVG--GRKCQDIDECSQDPSLCLPHG 881

Query: 442 LCFNTQGSFHCGCLPGWVLAPNGVSC 467
            C N QGS+ C C  G+    +   C
Sbjct: 882 ACKNLQGSYVCVCDEGFTPTQDQHGC 907



 Score =  116 bits (290), Expect = 7e-26
 Identities = 98/302 (32%), Positives = 129/302 (42%), Gaps = 55/302 (18%)

Query: 196 PGQVTYTTPFQTTSSSL---EAVPFASAANVACGEGDKDETQSHYFLCKEKAPDVFDWGS 252
           P QVT T   +   +     E VP     +  C  G +   Q  Y +   +  +    G 
Sbjct: 569 PTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNEC-EAEPCGP 627

Query: 253 SGPLCVSP--KYGCNFNNG----------------GCHQD--CFEGG-----DGSFLCGC 287
              +C++    Y C+ N G                 C +   C +GG      G + C C
Sbjct: 628 GRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNC 687

Query: 288 RPGFRLLDDLVTCASRNPCSSS--PCRGGATCVLGPHGK------NYTC-RCPQGYQLDS 338
            PG+RL       ASR P       CR  ++C   P GK      ++ C  C  GY+   
Sbjct: 688 YPGYRLK------ASRPPVCEDIDECRDPSSC---PDGKCENKPGSFKCIACQPGYRSQG 738

Query: 339 SQLDCVDVDECQD-SPCAQE-CVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPC 396
               C DV+EC + SPC+   C N PG FRC C  GY P   G  +C DVDEC  G   C
Sbjct: 739 GGA-CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGR-SCLDVDECEAG-DVC 795

Query: 397 AQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCL 455
             G C+NT GSF C C  GY L+  D + C+D+DEC  P   +    C NT GS+ C C 
Sbjct: 796 DNGICSNTPGSFQCQCLSGYHLS-RDRSHCEDIDECDFPAACIGGD-CINTNGSYRCLCP 853

Query: 456 PG 457
            G
Sbjct: 854 QG 855



 Score =  105 bits (261), Expect = 2e-22
 Identities = 63/175 (36%), Positives = 80/175 (45%), Gaps = 11/175 (6%)

Query: 313 GGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQE---CVNTPGGFRCEC 369
           G   CV GP   +Y+C C  GY+       CVDV+EC+  PC      C+NT G + C C
Sbjct: 586 GHGECVPGP--PDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHC 643

Query: 370 WVGYE-PGGPGEGACQDVDECALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDGTQCQ 426
             GY    G G  +C D++ECA     C  G  C N  G + C+C  GY L       C+
Sbjct: 644 NRGYRLHVGAGGRSCVDLNECAKPHL-CGDGGFCINFPGHYKCNCYPGYRLKASRPPVCE 702

Query: 427 DVDECVGPGGPLCDSLCFNTQGSFHC-GCLPGWVLAPNGVSCTMGPVSLGPPSGP 480
           D+DEC  P     D  C N  GSF C  C PG+     G    +   + G P  P
Sbjct: 703 DIDECRDPSS-CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSP 756



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 60/192 (31%), Positives = 88/192 (45%), Gaps = 24/192 (12%)

Query: 257 CVSPKYGCNFNNGGCHQD---CFEGGD----------GSFLCGCRPGFRLLDDLVTCASR 303
           C++ + G     GG  +D   C EG            GSF C C  G+    D  +C   
Sbjct: 727 CIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV 786

Query: 304 NPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCA---QECVN 360
           + C +        C   P   ++ C+C  GY L   +  C D+DEC D P A    +C+N
Sbjct: 787 DECEAGDVCDNGICSNTPG--SFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDCIN 843

Query: 361 TPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQ--GCTNTDGSFHCSCEEGYVLA 418
           T G +RC C  G+   G  +  CQD+DEC+   S C     C N  GS+ C C+EG+   
Sbjct: 844 TNGSYRCLCPQGHRLVGGRK--CQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFT-P 900

Query: 419 GEDGTQCQDVDE 430
            +D   C++V++
Sbjct: 901 TQDQHGCEEVEQ 912



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 37/83 (44%), Positives = 44/83 (53%), Gaps = 10/83 (12%)

Query: 308  SSPCRG-GATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSP-----CAQE-CVN 360
            S  CR     CV  P G    C CP G+QLD+S+  CVD+DEC++       C  E CVN
Sbjct: 1171 SDECRCVSGRCVPRPGGA--VCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVN 1228

Query: 361  TPGGFRCECWVGYEPGGPGEGAC 383
            T G FRC C  G+    P  GAC
Sbjct: 1229 TSGSFRCVCKAGFARSRP-HGAC 1250



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 65/219 (29%), Positives = 82/219 (37%), Gaps = 58/219 (26%)

Query: 308  SSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQD-SPCAQ-ECVNTPGGF 365
            S  C+ G  CV    G  Y C C QG+  D + L+CVDVDEC D S C    C NT GG+
Sbjct: 1002 SEICKEGK-CVNTQPG--YECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGY 1058

Query: 366  RCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQC 425
            RC C    E   P +  C   +E  + R+P  +             +  +   GEDG   
Sbjct: 1059 RCACTPPAE-YSPAQRQCLSPEE--MERAPERR-------------DVCWSQRGEDGM-- 1100

Query: 426  QDVDECVGP-GGPLC--DSLCFNTQGSFHCGCLPGWVLAPNGVSC-------------TM 469
                 C GP  GP    D  C      +   C P     P G                  
Sbjct: 1101 -----CAGPLAGPALTFDDCCCRQGRGWGAQCRP---CPPRGAGSHCPTSQSESNSFWDT 1152

Query: 470  GPVSLGPPSGPPDEEDKGEKE--------GSTVPRAATA 500
             P+ LG    PP +ED  E++        G  VPR   A
Sbjct: 1153 SPLLLGK---PPRDEDSSEEDSDECRCVSGRCVPRPGGA 1188



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 59/235 (25%), Positives = 80/235 (34%), Gaps = 60/235 (25%)

Query: 285  CGCRPGFRLLDDLVTCASRNPC-SSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDC 343
            C C+ GF    +L+ C   + C   S CR G   V       Y C C    +   +Q  C
Sbjct: 1019 CYCKQGFYYDGNLLECVDVDECLDESNCRNG---VCENTRGGYRCACTPPAEYSPAQRQC 1075

Query: 344  VDVDECQDSP---------------CAQE-----------CVNTPGGFRCECWVGYEPGG 377
            +  +E + +P               CA             C     G+  +C     P G
Sbjct: 1076 LSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQC-RPCPPRG 1134

Query: 378  PG---------EGACQDVDECALGRSP--------------CAQG-CTNTDGSFHCSCEE 413
             G           +  D     LG+ P              C  G C    G   C C  
Sbjct: 1135 AGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPG 1194

Query: 414  GYVLAGEDGTQCQDVDEC--VGPGGPLCDS-LCFNTQGSFHCGCLPGWVLA-PNG 464
            G+ L      +C D+DEC  +   G LC S  C NT GSF C C  G+  + P+G
Sbjct: 1195 GFQL-DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHG 1248



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 5/64 (7%)

Query: 405 GSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC-DSLCFNTQGSFHCGCLPGWVLAPN 463
           G     C +GY     + T CQD++EC  PG  +C    C N  GS+ C C PG  L P+
Sbjct: 335 GEVGADCPQGYKRL--NSTHCQDINECAMPG--VCRHGDCLNNPGSYRCVCPPGHSLGPS 390

Query: 464 GVSC 467
              C
Sbjct: 391 RTQC 394



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 59/221 (26%), Positives = 80/221 (36%), Gaps = 34/221 (15%)

Query: 320 GPHGKNYTCRCPQGYQLDSSQLDCVDVDEC-QDSPCAQ-ECVNTPGGFRCECWVGYEPGG 377
           GP        CPQGY+  +S   C D++EC     C   +C+N PG +RC C  G+   G
Sbjct: 331 GPVRGEVGADCPQGYKRLNST-HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL-G 388

Query: 378 PGEGAC-----QDVDECALGRSP---CAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVD 429
           P    C     ++   C    SP   C    T       C C  G       G +CQ   
Sbjct: 389 PSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAW----GARCQ--- 441

Query: 430 ECVGPGGPLCDSLC-----FNTQGSFHCGCLPG-----WVLAPNGVSCTMGPVSL-GPPS 478
            C   G      +C     ++   S     + G       L P+G      P  L   PS
Sbjct: 442 RCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDG---PPKPQQLPESPS 498

Query: 479 GPPDEEDKGEKEGSTVPRAATASPTRGPEGTPKATPTTSRP 519
             P  ED  E+ G T   +  +      +  P AT T +RP
Sbjct: 499 QAPPPEDTEEERGVTTD-SPVSEERSVQQSHPTATTTPARP 538


>gi|110347437 latent transforming growth factor beta binding protein
           4 isoform c [Homo sapiens]
          Length = 1557

 Score =  137 bits (344), Expect = 4e-32
 Identities = 82/225 (36%), Positives = 102/225 (45%), Gaps = 15/225 (6%)

Query: 251 GSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP 310
           G  G  C      C      C     +   GSF C C  GFR       C   + C+ SP
Sbjct: 634 GFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSP 693

Query: 311 CRGGATCVLGPHGK---NYTCRCPQGYQLDSSQLDCVDVDECQDSPCA--QECVNTPGGF 365
                 C  G       ++ C CP G+Q +++  +C DVDEC++      QECVN+PG F
Sbjct: 694 ----PPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSF 749

Query: 366 RCE-CWVGYEPGGPGEGACQDVDECALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDG 422
           +C  C  G+       G C DVDEC+ G  PC     CTNT+GSF CSC  GY       
Sbjct: 750 QCRTCPSGHHLH---RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRP 806

Query: 423 TQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
             C DV+EC+          C NT GSF C C PG+   P G SC
Sbjct: 807 GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC 851



 Score =  134 bits (338), Expect = 2e-31
 Identities = 81/198 (40%), Positives = 91/198 (45%), Gaps = 16/198 (8%)

Query: 277 EGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGK---NYTCRCPQG 333
           E   GSF C C PGFR       C   + C   P      C LG       ++ C CP G
Sbjct: 537 ENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVP----PPCDLGRCENTPGSFLCVCPAG 592

Query: 334 YQLDSSQLDCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECA 390
           YQ       C DVDEC  SP  C +  C N PG FRC C  G+     G    +DVDECA
Sbjct: 593 YQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFR----GSACEEDVDECA 648

Query: 391 LGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGS 449
               PC  G C NT GSFHC+C  G+   G  G  CQDVDEC     P     C NT+GS
Sbjct: 649 QEPPPCGPGRCDNTAGSFHCACPAGFRSRGP-GAPCQDVDECARSPPPCTYGRCENTEGS 707

Query: 450 FHCGCLPGWVLAPNGVSC 467
           F C C  G+     G  C
Sbjct: 708 FQCVCPMGFQPNTAGSEC 725



 Score =  124 bits (311), Expect = 3e-28
 Identities = 91/245 (37%), Positives = 112/245 (45%), Gaps = 28/245 (11%)

Query: 277 EGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATCVLGPHGKNYTCRCPQGY 334
           E   GSFLC C  G++      +C   + C+ SP  C  GA C   P   ++ C CP G+
Sbjct: 579 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA-CKNLPG--SFRCVCPAGF 635

Query: 335 QLDSSQLDCVDVDEC--QDSPCAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECAL 391
           +  + +    DVDEC  +  PC    C NT G F C C  G+   GPG   CQDVDECA 
Sbjct: 636 RGSACE---EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPG-APCQDVDECAR 691

Query: 392 GRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVG----PGGPLCDSLCFNT 446
              PC  G C NT+GSF C C  G+      G++C+DVDEC      PG       C N+
Sbjct: 692 SPPPCTYGRCENTEGSFQCVCPMGFQ-PNTAGSECEDVDECENHLACPGQE-----CVNS 745

Query: 447 QGSFHCGCLPGWVLAPNGVSCTMGPVSLG-PPSGPPDEEDKGEKEGSTVPRAATASPTRG 505
            GSF C   P       G    +   S G PP GP         EGS   R + A   R 
Sbjct: 746 PGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGP--HGHCTNTEGSF--RCSCAPGYRA 801

Query: 506 PEGTP 510
           P G P
Sbjct: 802 PSGRP 806



 Score =  122 bits (307), Expect = 8e-28
 Identities = 77/185 (41%), Positives = 86/185 (46%), Gaps = 19/185 (10%)

Query: 303 RNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQ--DSPCAQ-ECV 359
           RNP    P R    C+  P G  YTC C  G++L      C+DVDEC+    PCA   C 
Sbjct: 484 RNPQVCGPGR----CISRPSG--YTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCE 537

Query: 360 NTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLA 418
           N+PG FRC C  G+   GP    C DVDEC     PC  G C NT GSF C C  GY  A
Sbjct: 538 NSPGSFRCVCGPGFR-AGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGY-QA 595

Query: 419 GEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGW---VLAPNGVSCTMGPVSLG 475
              G  CQDVDEC    G      C N  GSF C C  G+       +   C   P    
Sbjct: 596 APHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEP---- 651

Query: 476 PPSGP 480
           PP GP
Sbjct: 652 PPCGP 656



 Score =  122 bits (307), Expect = 8e-28
 Identities = 101/283 (35%), Positives = 117/283 (41%), Gaps = 34/283 (12%)

Query: 271  CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSS--PCRGGATCVLGPHGKNYTC 328
            C        DGSF C C PG R   DL +C   + C        G   C   P       
Sbjct: 863  CQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVR 922

Query: 329  RCPQGYQLDSSQLDCVDVDECQD---SPC-AQECVNTPGGFRCE--CWVGYEPGGPGEGA 382
             C  GY     +  C DVDECQ+     C AQ C NTPG +RC   C  GY+P  PG G 
Sbjct: 923  DCDPGYHA-GPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPT-PG-GG 979

Query: 383  CQDVDECALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCD 440
            CQDVDEC   RS C     C N  GSF C C++GY  A  DG  C DV+EC    G    
Sbjct: 980  CQDVDECR-NRSFCGAHAVCQNLPGSFQCLCDQGYEGA-RDGRHCVDVNECETLQGVCGA 1037

Query: 441  SLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSG--PPDEEDKGEKEGSTVPRAA 498
            +LC N +GSF C C       PN       P    P +G   P     G   GS     A
Sbjct: 1038 ALCENVEGSFLCVC-------PN------SPEEFDPMTGRCVPPRTSAGTFPGS--QPQA 1082

Query: 499  TASPTRGPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSP 541
             ASP       P   P   RPS     P+ S   +    + +P
Sbjct: 1083 PASPVL--PARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAP 1123



 Score =  122 bits (306), Expect = 1e-27
 Identities = 87/246 (35%), Positives = 113/246 (45%), Gaps = 39/246 (15%)

Query: 235 SHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLL 294
           S + L + +  DV +  S  P C            G H  C    +GSF C C PG+R  
Sbjct: 756 SGHHLHRGRCTDVDECSSGAPPC------------GPHGHC-TNTEGSFRCSCAPGYR-- 800

Query: 295 DDLVTCASRNPCSS-SPCRGGATCVLGPHGK------NYTCRCPQGYQLDSSQLDCVDVD 347
                     PC+  + C  G  C   PHG+      ++ C C  GY+       C+DVD
Sbjct: 801 ---APSGRPGPCADVNECLEGDFCF--PHGECLNTDGSFACTCAPGYRPGPRGASCLDVD 855

Query: 348 ECQDSPCAQE--CVNTPGGFRCECWVGYEPGGPGEGACQDVDEC-ALGRSPC-AQGCTNT 403
           EC +    Q   C NT G F C C  G+   GP   +C DVDEC   G + C +Q C N+
Sbjct: 856 ECSEEDLCQSGICTNTDGSFECICPPGHR-AGPDLASCLDVDECRERGPALCGSQRCENS 914

Query: 404 DGSFHC--SCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS-LCFNTQGSFHC--GCLPGW 458
            GS+ C   C+ GY  AG +GT C DVDEC   G  +C +  C NT GS+ C   C PG+
Sbjct: 915 PGSYRCVRDCDPGY-HAGPEGT-CDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGY 972

Query: 459 VLAPNG 464
              P G
Sbjct: 973 QPTPGG 978



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 52/123 (42%), Positives = 62/123 (50%), Gaps = 6/123 (4%)

Query: 349 CQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTD 404
           CQ +P  C    C++ P G+ C C  G+     G   C DVDEC     PCA G C N+ 
Sbjct: 482 CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGT-RCIDVDECRRVPPPCAPGRCENSP 540

Query: 405 GSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNG 464
           GSF C C  G+  AG    +C DVDEC     P     C NT GSF C C  G+  AP+G
Sbjct: 541 GSFRCVCGPGF-RAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHG 599

Query: 465 VSC 467
            SC
Sbjct: 600 ASC 602



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 60/173 (34%), Positives = 73/173 (42%), Gaps = 27/173 (15%)

Query: 320  GPHGKNYTCRCP--QGYQLDSSQLDCV-DVDECQ---DSPCAQE-CVNTPGGFRCECWVG 372
            G     Y   CP  +GY   S  L    DVDECQ   D  C    CVNT  G+ C C  G
Sbjct: 1158 GTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNG 1217

Query: 373  YEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGED----GTQCQD 427
            Y         C D DECA     C  G C NT GS+HC+CE   VL G        + Q 
Sbjct: 1218 YYYHTQ-RLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQS 1276

Query: 428  VDECVG-----PGGPL-CDSLCFNTQGSF-HCGCLPG--WVLAPNGVSCTMGP 471
            +D+ +G      G  L C     + Q ++  C CL G  W     G+ C + P
Sbjct: 1277 LDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAW-----GMDCALCP 1324



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 30/71 (42%), Positives = 41/71 (57%), Gaps = 9/71 (12%)

Query: 311  CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQ------ECVNTPGG 364
            C  G  CV  P G  +TCRC  GY+LD +++ CVD++EC ++  A        C+NT G 
Sbjct: 1476 CTNGR-CVRVPEG--FTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGS 1532

Query: 365  FRCECWVGYEP 375
            FRC C  G+ P
Sbjct: 1533 FRCICRPGFAP 1543



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 69/249 (27%), Positives = 88/249 (35%), Gaps = 39/249 (15%)

Query: 345 DVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNT 403
           D   C +     E V+ P G    C  G+E      G+C+DVDECA G   C  G C NT
Sbjct: 256 DCQLCSERLGNSERVSAPDG---PCPTGFERVN---GSCEDVDECATG-GRCQHGECANT 308

Query: 404 DGSFHCSCEEGYVLAGEDGTQCQD--VDECVGPGGPLCDSLCFNTQGSFHCG-------- 453
            G + C C +G++L     +      + E  GP        CF       C         
Sbjct: 309 RGGYTCVCPDGFLLDSSRSSCISQHVISEAKGP--------CFRVLRDGGCSLPILRNIT 360

Query: 454 ---CLPGWVLAPNGVSCTMGPV--SLG----PPSGPPDEEDKGEKEGSTVPRAATASPTR 504
              C    V    G  C + P   S G     P+GP       +   +T P      P R
Sbjct: 361 KQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLG--QEPPR 418

Query: 505 GPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSPGVWREPSIHHATAASGPQEPAGG 564
                P+  P TSRPS          P     P   PG   E  +    A +GP+ P  G
Sbjct: 419 VSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPG--PELPLPSIPAWTGPEIPESG 476

Query: 565 DSSVATQNN 573
            SS   Q N
Sbjct: 477 PSSGMCQRN 485



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 45/125 (36%), Positives = 52/125 (41%), Gaps = 9/125 (7%)

Query: 343  CVDVDECQDSPCA-QECVNTPGG---FRCECWVGYEPGGPGEGACQDVDECALGRSP-CA 397
            C  V E   S C  Q+C  T        C    GY          +DVDEC L R   C 
Sbjct: 1140 CCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCK 1199

Query: 398  QG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS-LCFNTQGSFHCGCL 455
             G C NT   + C C  GY    +   +C D DEC     P C+   C NT GS+HC C 
Sbjct: 1200 SGVCVNTAPGYSCYCSNGYYYHTQR-LECIDNDECADEE-PACEGGRCVNTVGSYHCTCE 1257

Query: 456  PGWVL 460
            P  VL
Sbjct: 1258 PPLVL 1262



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 35/99 (35%), Positives = 47/99 (47%), Gaps = 10/99 (10%)

Query: 321  PHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGE 380
            P G +Y     + Y+   ++ +C  +D C +      CV  P GF C C+ GY       
Sbjct: 1449 PEGGSYAGSLAEPYEELEAE-ECGILDGCTNG----RCVRVPEGFTCRCFDGYRLDMT-R 1502

Query: 381  GACQDVDEC--ALGRSP-CAQG-CTNTDGSFHCSCEEGY 415
             AC D++EC  A   SP C    C NTDGSF C C  G+
Sbjct: 1503 MACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1541



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 24/62 (38%), Positives = 31/62 (50%), Gaps = 6/62 (9%)

Query: 311  CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQE---CVNTPGGFRC 367
            C+ G      P    Y+C C  GY   + +L+C+D DEC D   A E   CVNT G + C
Sbjct: 1198 CKSGVCVNTAP---GYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHC 1254

Query: 368  EC 369
             C
Sbjct: 1255 TC 1256



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 31/81 (38%), Positives = 39/81 (48%), Gaps = 14/81 (17%)

Query: 383  CQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQ--CQDVDEC--VGPGGPL 438
            C  +D C  GR      C      F C C +GY L   D T+  C D++EC       PL
Sbjct: 1470 CGILDGCTNGR------CVRVPEGFTCRCFDGYRL---DMTRMACVDINECDEAEAASPL 1520

Query: 439  C-DSLCFNTQGSFHCGCLPGW 458
            C ++ C NT GSF C C PG+
Sbjct: 1521 CVNARCLNTDGSFRCICRPGF 1541



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 28/91 (30%), Positives = 41/91 (45%), Gaps = 10/91 (10%)

Query: 379 GEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQ--CQDVDECVGPGG 436
           G G    V +C L    C++   N++     S  +G    G +     C+DVDEC   GG
Sbjct: 247 GAGLAWGVHDCQL----CSERLGNSE---RVSAPDGPCPTGFERVNGSCEDVDECA-TGG 298

Query: 437 PLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
                 C NT+G + C C  G++L  +  SC
Sbjct: 299 RCQHGECANTRGGYTCVCPDGFLLDSSRSSC 329


>gi|110347412 latent transforming growth factor beta binding protein
           4 isoform b [Homo sapiens]
          Length = 1587

 Score =  137 bits (344), Expect = 4e-32
 Identities = 82/225 (36%), Positives = 102/225 (45%), Gaps = 15/225 (6%)

Query: 251 GSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP 310
           G  G  C      C      C     +   GSF C C  GFR       C   + C+ SP
Sbjct: 664 GFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSP 723

Query: 311 CRGGATCVLGPHGK---NYTCRCPQGYQLDSSQLDCVDVDECQDSPCA--QECVNTPGGF 365
                 C  G       ++ C CP G+Q +++  +C DVDEC++      QECVN+PG F
Sbjct: 724 ----PPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSF 779

Query: 366 RCE-CWVGYEPGGPGEGACQDVDECALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDG 422
           +C  C  G+       G C DVDEC+ G  PC     CTNT+GSF CSC  GY       
Sbjct: 780 QCRTCPSGHHLH---RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRP 836

Query: 423 TQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
             C DV+EC+          C NT GSF C C PG+   P G SC
Sbjct: 837 GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC 881



 Score =  134 bits (338), Expect = 2e-31
 Identities = 81/198 (40%), Positives = 91/198 (45%), Gaps = 16/198 (8%)

Query: 277 EGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGK---NYTCRCPQG 333
           E   GSF C C PGFR       C   + C   P      C LG       ++ C CP G
Sbjct: 567 ENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVP----PPCDLGRCENTPGSFLCVCPAG 622

Query: 334 YQLDSSQLDCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECA 390
           YQ       C DVDEC  SP  C +  C N PG FRC C  G+     G    +DVDECA
Sbjct: 623 YQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFR----GSACEEDVDECA 678

Query: 391 LGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGS 449
               PC  G C NT GSFHC+C  G+   G  G  CQDVDEC     P     C NT+GS
Sbjct: 679 QEPPPCGPGRCDNTAGSFHCACPAGFRSRGP-GAPCQDVDECARSPPPCTYGRCENTEGS 737

Query: 450 FHCGCLPGWVLAPNGVSC 467
           F C C  G+     G  C
Sbjct: 738 FQCVCPMGFQPNTAGSEC 755



 Score =  124 bits (311), Expect = 3e-28
 Identities = 91/245 (37%), Positives = 112/245 (45%), Gaps = 28/245 (11%)

Query: 277 EGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATCVLGPHGKNYTCRCPQGY 334
           E   GSFLC C  G++      +C   + C+ SP  C  GA C   P   ++ C CP G+
Sbjct: 609 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA-CKNLPG--SFRCVCPAGF 665

Query: 335 QLDSSQLDCVDVDEC--QDSPCAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECAL 391
           +  + +    DVDEC  +  PC    C NT G F C C  G+   GPG   CQDVDECA 
Sbjct: 666 RGSACE---EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPG-APCQDVDECAR 721

Query: 392 GRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVG----PGGPLCDSLCFNT 446
              PC  G C NT+GSF C C  G+      G++C+DVDEC      PG       C N+
Sbjct: 722 SPPPCTYGRCENTEGSFQCVCPMGFQ-PNTAGSECEDVDECENHLACPGQE-----CVNS 775

Query: 447 QGSFHCGCLPGWVLAPNGVSCTMGPVSLG-PPSGPPDEEDKGEKEGSTVPRAATASPTRG 505
            GSF C   P       G    +   S G PP GP         EGS   R + A   R 
Sbjct: 776 PGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGP--HGHCTNTEGSF--RCSCAPGYRA 831

Query: 506 PEGTP 510
           P G P
Sbjct: 832 PSGRP 836



 Score =  122 bits (307), Expect = 8e-28
 Identities = 77/185 (41%), Positives = 86/185 (46%), Gaps = 19/185 (10%)

Query: 303 RNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQ--DSPCAQ-ECV 359
           RNP    P R    C+  P G  YTC C  G++L      C+DVDEC+    PCA   C 
Sbjct: 514 RNPQVCGPGR----CISRPSG--YTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCE 567

Query: 360 NTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLA 418
           N+PG FRC C  G+   GP    C DVDEC     PC  G C NT GSF C C  GY  A
Sbjct: 568 NSPGSFRCVCGPGFR-AGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGY-QA 625

Query: 419 GEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGW---VLAPNGVSCTMGPVSLG 475
              G  CQDVDEC    G      C N  GSF C C  G+       +   C   P    
Sbjct: 626 APHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEP---- 681

Query: 476 PPSGP 480
           PP GP
Sbjct: 682 PPCGP 686



 Score =  122 bits (307), Expect = 8e-28
 Identities = 101/283 (35%), Positives = 117/283 (41%), Gaps = 34/283 (12%)

Query: 271  CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSS--PCRGGATCVLGPHGKNYTC 328
            C        DGSF C C PG R   DL +C   + C        G   C   P       
Sbjct: 893  CQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVR 952

Query: 329  RCPQGYQLDSSQLDCVDVDECQD---SPC-AQECVNTPGGFRCE--CWVGYEPGGPGEGA 382
             C  GY     +  C DVDECQ+     C AQ C NTPG +RC   C  GY+P  PG G 
Sbjct: 953  DCDPGYHA-GPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPT-PG-GG 1009

Query: 383  CQDVDECALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCD 440
            CQDVDEC   RS C     C N  GSF C C++GY  A  DG  C DV+EC    G    
Sbjct: 1010 CQDVDECR-NRSFCGAHAVCQNLPGSFQCLCDQGYEGA-RDGRHCVDVNECETLQGVCGA 1067

Query: 441  SLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSG--PPDEEDKGEKEGSTVPRAA 498
            +LC N +GSF C C       PN       P    P +G   P     G   GS     A
Sbjct: 1068 ALCENVEGSFLCVC-------PN------SPEEFDPMTGRCVPPRTSAGTFPGS--QPQA 1112

Query: 499  TASPTRGPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSP 541
             ASP       P   P   RPS     P+ S   +    + +P
Sbjct: 1113 PASPVL--PARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAP 1153



 Score =  122 bits (306), Expect = 1e-27
 Identities = 87/246 (35%), Positives = 113/246 (45%), Gaps = 39/246 (15%)

Query: 235  SHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLL 294
            S + L + +  DV +  S  P C            G H  C    +GSF C C PG+R  
Sbjct: 786  SGHHLHRGRCTDVDECSSGAPPC------------GPHGHC-TNTEGSFRCSCAPGYR-- 830

Query: 295  DDLVTCASRNPCSS-SPCRGGATCVLGPHGK------NYTCRCPQGYQLDSSQLDCVDVD 347
                      PC+  + C  G  C   PHG+      ++ C C  GY+       C+DVD
Sbjct: 831  ---APSGRPGPCADVNECLEGDFCF--PHGECLNTDGSFACTCAPGYRPGPRGASCLDVD 885

Query: 348  ECQDSPCAQE--CVNTPGGFRCECWVGYEPGGPGEGACQDVDEC-ALGRSPC-AQGCTNT 403
            EC +    Q   C NT G F C C  G+   GP   +C DVDEC   G + C +Q C N+
Sbjct: 886  ECSEEDLCQSGICTNTDGSFECICPPGHR-AGPDLASCLDVDECRERGPALCGSQRCENS 944

Query: 404  DGSFHC--SCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS-LCFNTQGSFHC--GCLPGW 458
             GS+ C   C+ GY  AG +GT C DVDEC   G  +C +  C NT GS+ C   C PG+
Sbjct: 945  PGSYRCVRDCDPGY-HAGPEGT-CDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGY 1002

Query: 459  VLAPNG 464
               P G
Sbjct: 1003 QPTPGG 1008



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 52/123 (42%), Positives = 62/123 (50%), Gaps = 6/123 (4%)

Query: 349 CQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTD 404
           CQ +P  C    C++ P G+ C C  G+     G   C DVDEC     PCA G C N+ 
Sbjct: 512 CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGT-RCIDVDECRRVPPPCAPGRCENSP 570

Query: 405 GSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNG 464
           GSF C C  G+  AG    +C DVDEC     P     C NT GSF C C  G+  AP+G
Sbjct: 571 GSFRCVCGPGF-RAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHG 629

Query: 465 VSC 467
            SC
Sbjct: 630 ASC 632



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 60/173 (34%), Positives = 73/173 (42%), Gaps = 27/173 (15%)

Query: 320  GPHGKNYTCRCP--QGYQLDSSQLDCV-DVDECQ---DSPCAQE-CVNTPGGFRCECWVG 372
            G     Y   CP  +GY   S  L    DVDECQ   D  C    CVNT  G+ C C  G
Sbjct: 1188 GTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNG 1247

Query: 373  YEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGED----GTQCQD 427
            Y         C D DECA     C  G C NT GS+HC+CE   VL G        + Q 
Sbjct: 1248 YYYHTQ-RLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQS 1306

Query: 428  VDECVG-----PGGPL-CDSLCFNTQGSF-HCGCLPG--WVLAPNGVSCTMGP 471
            +D+ +G      G  L C     + Q ++  C CL G  W     G+ C + P
Sbjct: 1307 LDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAW-----GMDCALCP 1354



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 30/71 (42%), Positives = 41/71 (57%), Gaps = 9/71 (12%)

Query: 311  CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQ------ECVNTPGG 364
            C  G  CV  P G  +TCRC  GY+LD +++ CVD++EC ++  A        C+NT G 
Sbjct: 1506 CTNGR-CVRVPEG--FTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGS 1562

Query: 365  FRCECWVGYEP 375
            FRC C  G+ P
Sbjct: 1563 FRCICRPGFAP 1573



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 69/249 (27%), Positives = 88/249 (35%), Gaps = 39/249 (15%)

Query: 345 DVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNT 403
           D   C +     E V+ P G    C  G+E      G+C+DVDECA G   C  G C NT
Sbjct: 286 DCQLCSERLGNSERVSAPDG---PCPTGFERVN---GSCEDVDECATG-GRCQHGECANT 338

Query: 404 DGSFHCSCEEGYVLAGEDGTQCQD--VDECVGPGGPLCDSLCFNTQGSFHCG-------- 453
            G + C C +G++L     +      + E  GP        CF       C         
Sbjct: 339 RGGYTCVCPDGFLLDSSRSSCISQHVISEAKGP--------CFRVLRDGGCSLPILRNIT 390

Query: 454 ---CLPGWVLAPNGVSCTMGPV--SLG----PPSGPPDEEDKGEKEGSTVPRAATASPTR 504
              C    V    G  C + P   S G     P+GP       +   +T P      P R
Sbjct: 391 KQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLG--QEPPR 448

Query: 505 GPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSPGVWREPSIHHATAASGPQEPAGG 564
                P+  P TSRPS          P     P   PG   E  +    A +GP+ P  G
Sbjct: 449 VSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPG--PELPLPSIPAWTGPEIPESG 506

Query: 565 DSSVATQNN 573
            SS   Q N
Sbjct: 507 PSSGMCQRN 515



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 45/125 (36%), Positives = 52/125 (41%), Gaps = 9/125 (7%)

Query: 343  CVDVDECQDSPCA-QECVNTPGG---FRCECWVGYEPGGPGEGACQDVDECALGRSP-CA 397
            C  V E   S C  Q+C  T        C    GY          +DVDEC L R   C 
Sbjct: 1170 CCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCK 1229

Query: 398  QG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS-LCFNTQGSFHCGCL 455
             G C NT   + C C  GY    +   +C D DEC     P C+   C NT GS+HC C 
Sbjct: 1230 SGVCVNTAPGYSCYCSNGYYYHTQR-LECIDNDECADEE-PACEGGRCVNTVGSYHCTCE 1287

Query: 456  PGWVL 460
            P  VL
Sbjct: 1288 PPLVL 1292



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 35/99 (35%), Positives = 47/99 (47%), Gaps = 10/99 (10%)

Query: 321  PHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGE 380
            P G +Y     + Y+   ++ +C  +D C +      CV  P GF C C+ GY       
Sbjct: 1479 PEGGSYAGSLAEPYEELEAE-ECGILDGCTNG----RCVRVPEGFTCRCFDGYRLDMT-R 1532

Query: 381  GACQDVDEC--ALGRSP-CAQG-CTNTDGSFHCSCEEGY 415
             AC D++EC  A   SP C    C NTDGSF C C  G+
Sbjct: 1533 MACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1571



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 24/62 (38%), Positives = 31/62 (50%), Gaps = 6/62 (9%)

Query: 311  CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQE---CVNTPGGFRC 367
            C+ G      P    Y+C C  GY   + +L+C+D DEC D   A E   CVNT G + C
Sbjct: 1228 CKSGVCVNTAP---GYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHC 1284

Query: 368  EC 369
             C
Sbjct: 1285 TC 1286



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 31/81 (38%), Positives = 39/81 (48%), Gaps = 14/81 (17%)

Query: 383  CQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQ--CQDVDEC--VGPGGPL 438
            C  +D C  GR      C      F C C +GY L   D T+  C D++EC       PL
Sbjct: 1500 CGILDGCTNGR------CVRVPEGFTCRCFDGYRL---DMTRMACVDINECDEAEAASPL 1550

Query: 439  C-DSLCFNTQGSFHCGCLPGW 458
            C ++ C NT GSF C C PG+
Sbjct: 1551 CVNARCLNTDGSFRCICRPGF 1571



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 28/91 (30%), Positives = 41/91 (45%), Gaps = 10/91 (10%)

Query: 379 GEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQ--CQDVDECVGPGG 436
           G G    V +C L    C++   N++     S  +G    G +     C+DVDEC   GG
Sbjct: 277 GAGLAWGVHDCQL----CSERLGNSE---RVSAPDGPCPTGFERVNGSCEDVDECA-TGG 328

Query: 437 PLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
                 C NT+G + C C  G++L  +  SC
Sbjct: 329 RCQHGECANTRGGYTCVCPDGFLLDSSRSSC 359


>gi|110347431 latent transforming growth factor beta binding protein
           4 isoform a [Homo sapiens]
          Length = 1624

 Score =  137 bits (344), Expect = 4e-32
 Identities = 82/225 (36%), Positives = 102/225 (45%), Gaps = 15/225 (6%)

Query: 251 GSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP 310
           G  G  C      C      C     +   GSF C C  GFR       C   + C+ SP
Sbjct: 701 GFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSP 760

Query: 311 CRGGATCVLGPHGK---NYTCRCPQGYQLDSSQLDCVDVDECQDSPCA--QECVNTPGGF 365
                 C  G       ++ C CP G+Q +++  +C DVDEC++      QECVN+PG F
Sbjct: 761 ----PPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSF 816

Query: 366 RCE-CWVGYEPGGPGEGACQDVDECALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDG 422
           +C  C  G+       G C DVDEC+ G  PC     CTNT+GSF CSC  GY       
Sbjct: 817 QCRTCPSGHHLH---RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRP 873

Query: 423 TQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
             C DV+EC+          C NT GSF C C PG+   P G SC
Sbjct: 874 GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC 918



 Score =  134 bits (338), Expect = 2e-31
 Identities = 81/198 (40%), Positives = 91/198 (45%), Gaps = 16/198 (8%)

Query: 277 EGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGK---NYTCRCPQG 333
           E   GSF C C PGFR       C   + C   P      C LG       ++ C CP G
Sbjct: 604 ENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVP----PPCDLGRCENTPGSFLCVCPAG 659

Query: 334 YQLDSSQLDCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECA 390
           YQ       C DVDEC  SP  C +  C N PG FRC C  G+     G    +DVDECA
Sbjct: 660 YQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFR----GSACEEDVDECA 715

Query: 391 LGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGS 449
               PC  G C NT GSFHC+C  G+   G  G  CQDVDEC     P     C NT+GS
Sbjct: 716 QEPPPCGPGRCDNTAGSFHCACPAGFRSRGP-GAPCQDVDECARSPPPCTYGRCENTEGS 774

Query: 450 FHCGCLPGWVLAPNGVSC 467
           F C C  G+     G  C
Sbjct: 775 FQCVCPMGFQPNTAGSEC 792



 Score =  124 bits (311), Expect = 3e-28
 Identities = 91/245 (37%), Positives = 112/245 (45%), Gaps = 28/245 (11%)

Query: 277 EGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATCVLGPHGKNYTCRCPQGY 334
           E   GSFLC C  G++      +C   + C+ SP  C  GA C   P   ++ C CP G+
Sbjct: 646 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA-CKNLPG--SFRCVCPAGF 702

Query: 335 QLDSSQLDCVDVDEC--QDSPCAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECAL 391
           +  + +    DVDEC  +  PC    C NT G F C C  G+   GPG   CQDVDECA 
Sbjct: 703 RGSACE---EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPG-APCQDVDECAR 758

Query: 392 GRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVG----PGGPLCDSLCFNT 446
              PC  G C NT+GSF C C  G+      G++C+DVDEC      PG       C N+
Sbjct: 759 SPPPCTYGRCENTEGSFQCVCPMGFQ-PNTAGSECEDVDECENHLACPGQE-----CVNS 812

Query: 447 QGSFHCGCLPGWVLAPNGVSCTMGPVSLG-PPSGPPDEEDKGEKEGSTVPRAATASPTRG 505
            GSF C   P       G    +   S G PP GP         EGS   R + A   R 
Sbjct: 813 PGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGP--HGHCTNTEGSF--RCSCAPGYRA 868

Query: 506 PEGTP 510
           P G P
Sbjct: 869 PSGRP 873



 Score =  122 bits (307), Expect = 8e-28
 Identities = 77/185 (41%), Positives = 86/185 (46%), Gaps = 19/185 (10%)

Query: 303 RNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQ--DSPCAQ-ECV 359
           RNP    P R    C+  P G  YTC C  G++L      C+DVDEC+    PCA   C 
Sbjct: 551 RNPQVCGPGR----CISRPSG--YTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCE 604

Query: 360 NTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLA 418
           N+PG FRC C  G+   GP    C DVDEC     PC  G C NT GSF C C  GY  A
Sbjct: 605 NSPGSFRCVCGPGFR-AGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGY-QA 662

Query: 419 GEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGW---VLAPNGVSCTMGPVSLG 475
              G  CQDVDEC    G      C N  GSF C C  G+       +   C   P    
Sbjct: 663 APHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEP---- 718

Query: 476 PPSGP 480
           PP GP
Sbjct: 719 PPCGP 723



 Score =  122 bits (307), Expect = 8e-28
 Identities = 101/283 (35%), Positives = 117/283 (41%), Gaps = 34/283 (12%)

Query: 271  CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSS--PCRGGATCVLGPHGKNYTC 328
            C        DGSF C C PG R   DL +C   + C        G   C   P       
Sbjct: 930  CQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVR 989

Query: 329  RCPQGYQLDSSQLDCVDVDECQD---SPC-AQECVNTPGGFRCE--CWVGYEPGGPGEGA 382
             C  GY     +  C DVDECQ+     C AQ C NTPG +RC   C  GY+P  PG G 
Sbjct: 990  DCDPGYHA-GPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPT-PG-GG 1046

Query: 383  CQDVDECALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCD 440
            CQDVDEC   RS C     C N  GSF C C++GY  A  DG  C DV+EC    G    
Sbjct: 1047 CQDVDECR-NRSFCGAHAVCQNLPGSFQCLCDQGYEGA-RDGRHCVDVNECETLQGVCGA 1104

Query: 441  SLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSG--PPDEEDKGEKEGSTVPRAA 498
            +LC N +GSF C C       PN       P    P +G   P     G   GS     A
Sbjct: 1105 ALCENVEGSFLCVC-------PN------SPEEFDPMTGRCVPPRTSAGTFPGS--QPQA 1149

Query: 499  TASPTRGPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSP 541
             ASP       P   P   RPS     P+ S   +    + +P
Sbjct: 1150 PASPVL--PARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAP 1190



 Score =  122 bits (306), Expect = 1e-27
 Identities = 87/246 (35%), Positives = 113/246 (45%), Gaps = 39/246 (15%)

Query: 235  SHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLL 294
            S + L + +  DV +  S  P C            G H  C    +GSF C C PG+R  
Sbjct: 823  SGHHLHRGRCTDVDECSSGAPPC------------GPHGHC-TNTEGSFRCSCAPGYR-- 867

Query: 295  DDLVTCASRNPCSS-SPCRGGATCVLGPHGK------NYTCRCPQGYQLDSSQLDCVDVD 347
                      PC+  + C  G  C   PHG+      ++ C C  GY+       C+DVD
Sbjct: 868  ---APSGRPGPCADVNECLEGDFCF--PHGECLNTDGSFACTCAPGYRPGPRGASCLDVD 922

Query: 348  ECQDSPCAQE--CVNTPGGFRCECWVGYEPGGPGEGACQDVDEC-ALGRSPC-AQGCTNT 403
            EC +    Q   C NT G F C C  G+   GP   +C DVDEC   G + C +Q C N+
Sbjct: 923  ECSEEDLCQSGICTNTDGSFECICPPGHR-AGPDLASCLDVDECRERGPALCGSQRCENS 981

Query: 404  DGSFHC--SCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS-LCFNTQGSFHC--GCLPGW 458
             GS+ C   C+ GY  AG +GT C DVDEC   G  +C +  C NT GS+ C   C PG+
Sbjct: 982  PGSYRCVRDCDPGY-HAGPEGT-CDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGY 1039

Query: 459  VLAPNG 464
               P G
Sbjct: 1040 QPTPGG 1045



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 52/123 (42%), Positives = 62/123 (50%), Gaps = 6/123 (4%)

Query: 349 CQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTD 404
           CQ +P  C    C++ P G+ C C  G+     G   C DVDEC     PCA G C N+ 
Sbjct: 549 CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGT-RCIDVDECRRVPPPCAPGRCENSP 607

Query: 405 GSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNG 464
           GSF C C  G+  AG    +C DVDEC     P     C NT GSF C C  G+  AP+G
Sbjct: 608 GSFRCVCGPGF-RAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHG 666

Query: 465 VSC 467
            SC
Sbjct: 667 ASC 669



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 60/173 (34%), Positives = 73/173 (42%), Gaps = 27/173 (15%)

Query: 320  GPHGKNYTCRCP--QGYQLDSSQLDCV-DVDECQ---DSPCAQE-CVNTPGGFRCECWVG 372
            G     Y   CP  +GY   S  L    DVDECQ   D  C    CVNT  G+ C C  G
Sbjct: 1225 GTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNG 1284

Query: 373  YEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGED----GTQCQD 427
            Y         C D DECA     C  G C NT GS+HC+CE   VL G        + Q 
Sbjct: 1285 YYYHTQ-RLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQS 1343

Query: 428  VDECVG-----PGGPL-CDSLCFNTQGSF-HCGCLPG--WVLAPNGVSCTMGP 471
            +D+ +G      G  L C     + Q ++  C CL G  W     G+ C + P
Sbjct: 1344 LDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAW-----GMDCALCP 1391



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 30/71 (42%), Positives = 41/71 (57%), Gaps = 9/71 (12%)

Query: 311  CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQ------ECVNTPGG 364
            C  G  CV  P G  +TCRC  GY+LD +++ CVD++EC ++  A        C+NT G 
Sbjct: 1543 CTNGR-CVRVPEG--FTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGS 1599

Query: 365  FRCECWVGYEP 375
            FRC C  G+ P
Sbjct: 1600 FRCICRPGFAP 1610



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 69/249 (27%), Positives = 88/249 (35%), Gaps = 39/249 (15%)

Query: 345 DVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNT 403
           D   C +     E V+ P G    C  G+E      G+C+DVDECA G   C  G C NT
Sbjct: 323 DCQLCSERLGNSERVSAPDG---PCPTGFERVN---GSCEDVDECATG-GRCQHGECANT 375

Query: 404 DGSFHCSCEEGYVLAGEDGTQCQD--VDECVGPGGPLCDSLCFNTQGSFHCG-------- 453
            G + C C +G++L     +      + E  GP        CF       C         
Sbjct: 376 RGGYTCVCPDGFLLDSSRSSCISQHVISEAKGP--------CFRVLRDGGCSLPILRNIT 427

Query: 454 ---CLPGWVLAPNGVSCTMGPV--SLG----PPSGPPDEEDKGEKEGSTVPRAATASPTR 504
              C    V    G  C + P   S G     P+GP       +   +T P      P R
Sbjct: 428 KQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLG--QEPPR 485

Query: 505 GPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSPGVWREPSIHHATAASGPQEPAGG 564
                P+  P TSRPS          P     P   PG   E  +    A +GP+ P  G
Sbjct: 486 VSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPG--PELPLPSIPAWTGPEIPESG 543

Query: 565 DSSVATQNN 573
            SS   Q N
Sbjct: 544 PSSGMCQRN 552



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 45/125 (36%), Positives = 52/125 (41%), Gaps = 9/125 (7%)

Query: 343  CVDVDECQDSPCA-QECVNTPGG---FRCECWVGYEPGGPGEGACQDVDECALGRSP-CA 397
            C  V E   S C  Q+C  T        C    GY          +DVDEC L R   C 
Sbjct: 1207 CCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCK 1266

Query: 398  QG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS-LCFNTQGSFHCGCL 455
             G C NT   + C C  GY    +   +C D DEC     P C+   C NT GS+HC C 
Sbjct: 1267 SGVCVNTAPGYSCYCSNGYYYHTQR-LECIDNDECADEE-PACEGGRCVNTVGSYHCTCE 1324

Query: 456  PGWVL 460
            P  VL
Sbjct: 1325 PPLVL 1329



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 35/99 (35%), Positives = 47/99 (47%), Gaps = 10/99 (10%)

Query: 321  PHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGE 380
            P G +Y     + Y+   ++ +C  +D C +      CV  P GF C C+ GY       
Sbjct: 1516 PEGGSYAGSLAEPYEELEAE-ECGILDGCTNG----RCVRVPEGFTCRCFDGYRLDMT-R 1569

Query: 381  GACQDVDEC--ALGRSP-CAQG-CTNTDGSFHCSCEEGY 415
             AC D++EC  A   SP C    C NTDGSF C C  G+
Sbjct: 1570 MACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1608



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 24/62 (38%), Positives = 31/62 (50%), Gaps = 6/62 (9%)

Query: 311  CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQE---CVNTPGGFRC 367
            C+ G      P    Y+C C  GY   + +L+C+D DEC D   A E   CVNT G + C
Sbjct: 1265 CKSGVCVNTAP---GYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHC 1321

Query: 368  EC 369
             C
Sbjct: 1322 TC 1323



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 31/81 (38%), Positives = 39/81 (48%), Gaps = 14/81 (17%)

Query: 383  CQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQ--CQDVDEC--VGPGGPL 438
            C  +D C  GR      C      F C C +GY L   D T+  C D++EC       PL
Sbjct: 1537 CGILDGCTNGR------CVRVPEGFTCRCFDGYRL---DMTRMACVDINECDEAEAASPL 1587

Query: 439  C-DSLCFNTQGSFHCGCLPGW 458
            C ++ C NT GSF C C PG+
Sbjct: 1588 CVNARCLNTDGSFRCICRPGF 1608



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 28/91 (30%), Positives = 41/91 (45%), Gaps = 10/91 (10%)

Query: 379 GEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQ--CQDVDECVGPGG 436
           G G    V +C L    C++   N++     S  +G    G +     C+DVDEC   GG
Sbjct: 314 GAGLAWGVHDCQL----CSERLGNSE---RVSAPDGPCPTGFERVNGSCEDVDECA-TGG 365

Query: 437 PLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
                 C NT+G + C C  G++L  +  SC
Sbjct: 366 RCQHGECANTRGGYTCVCPDGFLLDSSRSSC 396


>gi|19743803 fibulin 5 precursor [Homo sapiens]
          Length = 448

 Score =  134 bits (337), Expect = 3e-31
 Identities = 74/183 (40%), Positives = 96/183 (52%), Gaps = 11/183 (6%)

Query: 287 CRPGFRLLDDLVTCASRNPCS--SSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCV 344
           CR G+++ D+   C   + C+  S  C     C+    G  YTC C  GY L   Q  C+
Sbjct: 113 CRFGYQM-DESNQCVDVDECATDSHQCNPTQICINTEGG--YTCSCTDGYWLLEGQ--CL 167

Query: 345 DVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTD 404
           D+DEC+   C Q C N PG + C C  G+     G  +CQDV+ECA   +PC Q C NT 
Sbjct: 168 DIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGR-SCQDVNECAT-ENPCVQTCVNTY 225

Query: 405 GSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNG 464
           GSF C C+ GY L  EDG  C D+DEC      LC   C N  G++ C C PG++L  + 
Sbjct: 226 GSFICRCDPGYELE-EDGVHCSDMDEC-SFSEFLCQHECVNQPGTYFCSCPPGYILLDDN 283

Query: 465 VSC 467
            SC
Sbjct: 284 RSC 286



 Score =  119 bits (297), Expect = 1e-26
 Identities = 67/144 (46%), Positives = 79/144 (54%), Gaps = 15/144 (10%)

Query: 330 CPQGYQLDSSQLDCVDVDEC-----QDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQ 384
           C  GYQ+D S   CVDVDEC     Q +P  Q C+NT GG+ C C  GY      EG C 
Sbjct: 113 CRFGYQMDESN-QCVDVDECATDSHQCNP-TQICINTEGGYTCSCTDGY---WLLEGQCL 167

Query: 385 DVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCF 444
           D+DEC  G   C Q C N  GS+ C+C  G+ L  EDG  CQDV+EC       C   C 
Sbjct: 168 DIDECRYGY--CQQLCANVPGSYSCTCNPGFTL-NEDGRSCQDVNECATENP--CVQTCV 222

Query: 445 NTQGSFHCGCLPGWVLAPNGVSCT 468
           NT GSF C C PG+ L  +GV C+
Sbjct: 223 NTYGSFICRCDPGYELEEDGVHCS 246



 Score =  118 bits (295), Expect = 2e-26
 Identities = 68/198 (34%), Positives = 92/198 (46%), Gaps = 16/198 (8%)

Query: 257 CVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGAT 316
           C +  + CN       Q C    +G + C C  G+ LL+    C   + C    C+    
Sbjct: 131 CATDSHQCNPT-----QICINT-EGGYTCSCTDGYWLLEG--QCLDIDECRYGYCQQLCA 182

Query: 317 CVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQ-DSPCAQECVNTPGGFRCECWVGYEP 375
            V G    +Y+C C  G+ L+     C DV+EC  ++PC Q CVNT G F C C  GYE 
Sbjct: 183 NVPG----SYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYEL 238

Query: 376 GGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPG 435
              G   C D+DEC+     C   C N  G++ CSC  GY+L  +D   CQD++EC    
Sbjct: 239 EEDGVH-CSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILL-DDNRSCQDINECEHRN 296

Query: 436 GPL-CDSLCFNTQGSFHC 452
                   C+N QG F C
Sbjct: 297 HTCNLQQTCYNLQGGFKC 314



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 62/197 (31%), Positives = 78/197 (39%), Gaps = 59/197 (29%)

Query: 321 PHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCA----QECVNTPGGFRC--------- 367
           P   N   +C  G+ LD     C+D+DEC+  P A      CVN  GG+ C         
Sbjct: 18  PSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYR 77

Query: 368 ----------------------------------ECWVGYEPGGPGEGACQDVDECALGR 393
                                              C  GY+     +  C DVDECA   
Sbjct: 78  GPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQ--CVDVDECATDS 135

Query: 394 SPC--AQGCTNTDGSFHCSCEEGY-VLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSF 450
             C   Q C NT+G + CSC +GY +L G    QC D+DEC       C  LC N  GS+
Sbjct: 136 HQCNPTQICINTEGGYTCSCTDGYWLLEG----QCLDIDEC---RYGYCQQLCANVPGSY 188

Query: 451 HCGCLPGWVLAPNGVSC 467
            C C PG+ L  +G SC
Sbjct: 189 SCTCNPGFTLNEDGRSC 205



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 36/151 (23%), Positives = 53/151 (35%), Gaps = 52/151 (34%)

Query: 358 CVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCA--QGCTNTDGSFHC------ 409
           C+ +PG  + +C  G++      G C D+DEC      C     C N +G + C      
Sbjct: 16  CLPSPGNAQAQCTNGFDLDRQS-GQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74

Query: 410 -------------------------------------SCEEGYVLAGEDGTQCQDVDECV 432
                                                 C  GY +  ++  QC DVDEC 
Sbjct: 75  VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQM--DESNQCVDVDEC- 131

Query: 433 GPGGPLCD--SLCFNTQGSFHCGCLPG-WVL 460
                 C+   +C NT+G + C C  G W+L
Sbjct: 132 ATDSHQCNPTQICINTEGGYTCSCTDGYWLL 162



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 36/121 (29%), Positives = 44/121 (36%), Gaps = 27/121 (22%)

Query: 400 CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC-VGPGGPLCDSLCFNTQGSFHCGCLPGW 458
           C  + G+    C  G+ L  + G QC D+DEC   P     D +C N  G +   C+P  
Sbjct: 16  CLPSPGNAQAQCTNGFDLDRQSG-QCLDIDECRTIPEACRGDMMCVNQNGGYL--CIP-- 70

Query: 459 VLAPNGVSCTMGPVSLGPPSGPPDEEDKGEKEGSTVPRAATASPTRGPEGTPKATPTTSR 518
                       PV  GP S P      G       P  A A P   P       PT SR
Sbjct: 71  ---------RTNPVYRGPYSNPYSTPYSG-------PYPAAAPPLSAPN-----YPTISR 109

Query: 519 P 519
           P
Sbjct: 110 P 110


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score =  130 bits (327), Expect = 4e-30
 Identities = 65/147 (44%), Positives = 82/147 (55%), Gaps = 5/147 (3%)

Query: 325  NYTCRCPQGYQLDSSQLDCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEG 381
            ++ C C  G+ LD+ + +C D+DEC+ SP  C Q  CVNTPG F CEC+ GYE G     
Sbjct: 1008 SFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMK 1067

Query: 382  ACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCD 440
             C DVDECA     C  G CTNTDGS+ C C  G+ L  + GT C+D+DEC    G    
Sbjct: 1068 NCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAK-GTACEDIDECSLSDGLCPH 1126

Query: 441  SLCFNTQGSFHCGCLPGWVLAPNGVSC 467
              C N  G+F C C  G+   P+   C
Sbjct: 1127 GQCVNVIGAFQCSCHAGFQSTPDRQGC 1153



 Score =  130 bits (326), Expect = 5e-30
 Identities = 79/211 (37%), Positives = 103/211 (48%), Gaps = 13/211 (6%)

Query: 264  CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP-CRGGATCVLGPH 322
            C    G C         GSF C C  GF L      C   + C  SP   G  TCV  P 
Sbjct: 990  CKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTP- 1048

Query: 323  GKNYTCRCPQGYQLDSSQL-DCVDVDECQDSPC---AQECVNTPGGFRCECWVGYEPGGP 378
              ++ C C  GY+     + +C+DVDEC   P       C NT G ++C+C  G+E    
Sbjct: 1049 -GSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAK 1107

Query: 379  GEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC-VGPGG 436
            G  AC+D+DEC+L    C  G C N  G+F CSC  G+  +  D   C D++EC V  GG
Sbjct: 1108 GT-ACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGF-QSTPDRQGCVDINECRVQNGG 1165

Query: 437  PLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
              CD  C NT+GS+ C C  G+ L P+G +C
Sbjct: 1166 --CDVHCINTEGSYRCSCGQGYSLMPDGRAC 1194



 Score =  127 bits (320), Expect = 2e-29
 Identities = 76/211 (36%), Positives = 102/211 (48%), Gaps = 13/211 (6%)

Query: 264  CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLV-TCASRNPCSSSP--CRGGATCVLG 320
            C  +   C Q       GSF C C PG+     L+  C   + C+  P  CRGG TC   
Sbjct: 1032 CRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGG-TCT-- 1088

Query: 321  PHGKNYTCRCPQGYQLDSSQLDCVDVDECQ--DSPCAQ-ECVNTPGGFRCECWVGYEPGG 377
                +Y C+CP G++L +    C D+DEC   D  C   +CVN  G F+C C  G++   
Sbjct: 1089 NTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQ-ST 1147

Query: 378  PGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGP 437
            P    C D++EC +    C   C NT+GS+ CSC +GY L   DG  C DVDEC      
Sbjct: 1148 PDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLM-PDGRACADVDEC-EENPR 1205

Query: 438  LCD-SLCFNTQGSFHCGCLPGWVLAPNGVSC 467
            +CD   C N  G   C C  G++  P+  +C
Sbjct: 1206 VCDQGHCTNMPGGHRCLCYDGFMATPDMRTC 1236



 Score =  127 bits (320), Expect = 2e-29
 Identities = 95/293 (32%), Positives = 118/293 (40%), Gaps = 53/293 (18%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQ 340
            GSFLC C  G+ L +D  TC   + C+S        CV       +TCRCP G+      
Sbjct: 2425 GSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGA--FTCRCPPGFTQHHQA 2482

Query: 341  LDCVDVDEC--QDSPCAQE--CVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPC 396
              C D DEC  Q  PC     C NTPG FRCEC  G+     G G C+DV+EC  G   C
Sbjct: 2483 --CFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHG-CEDVNECD-GPHRC 2538

Query: 397  AQGCTNTDGSFHCSCEEGYVL-------------------------------------AG 419
              GC N  G + CSC +G+                                       +G
Sbjct: 2539 QHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSG 2598

Query: 420  EDGTQ----CQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLG 475
             D  Q    CQ+VDEC G  GP C   C NT G F CGC  G+  A  G  C  G     
Sbjct: 2599 FDFDQALGGCQEVDECAGRRGP-CSYSCANTPGGFLCGCPQGYFRAGQG-HCVSGLGFSP 2656

Query: 476  PPSGPPDEEDKGEKEGSTVPRAATASPTRGPEGTPKATPTTSRPSLSSDAPIT 528
             P   PD+E+    E     +    SP   P  +       +  +L S+A +T
Sbjct: 2657 GPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLATLDSEALLT 2709



 Score =  127 bits (318), Expect = 4e-29
 Identities = 87/250 (34%), Positives = 116/250 (46%), Gaps = 21/250 (8%)

Query: 225  CGEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGC--HQDCFEGGDGS 282
            C  GD + T+   F+C  +   +   G++G   V     C      C  H  C     GS
Sbjct: 1249 CLHGDCENTKGS-FVCHCQLGYMVRKGATGCSDVDE---CEVGGHNCDSHASCLNI-PGS 1303

Query: 283  FLCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATCVLGPHGKNYTCRCPQGYQLDSSQ 340
            F C C PG+  + D   C   + C S    C     C+  P   +Y C C QG+  D   
Sbjct: 1304 FSCRCLPGW--VGDGFECHDLDECVSQEHRCSPRGDCLNVPG--SYRCTCRQGFAGDG-- 1357

Query: 341  LDCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCA 397
              C D DEC ++   C   +C+N PGG+RCEC +G++P      ACQDVDECA G     
Sbjct: 1358 FFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPT-EDHRACQDVDECAQGNLCAF 1416

Query: 398  QGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPG 457
              C N  G F C C  GY L    G  C D++EC  P   + + +C NT GS+ C C   
Sbjct: 1417 GSCENLPGMFRCICNGGYEL-DRGGGNCTDINECADPVNCI-NGVCINTPGSYLCSCPQD 1474

Query: 458  WVLAPNGVSC 467
            + L P+GV C
Sbjct: 1475 FELNPSGVGC 1484



 Score =  126 bits (317), Expect = 5e-29
 Identities = 79/191 (41%), Positives = 100/191 (52%), Gaps = 14/191 (7%)

Query: 282 SFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQL 341
           S+ C C  G+   D    C   + C+SSPC  G  CV  P    Y CRC  G+Q   ++ 
Sbjct: 430 SYRCECNVGYTQ-DVRGECIDVDECTSSPCHHG-DCVNIPG--TYHCRCYPGFQATPTRQ 485

Query: 342 DCVDVDEC--QDSPC-AQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQ 398
            CVDVDEC      C    CVNT G F+C C  G+E    G+  C D +ECA   + C  
Sbjct: 486 ACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKN-CVDHNECATS-TMCVN 543

Query: 399 G-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC-DSLCFNTQGSFHCGCLP 456
           G C N DGSF C C+ G++LA   G  C D+DEC  PG  +C +  C NT+GSF C CL 
Sbjct: 544 GVCLNEDGSFSCLCKPGFLLA-PGGHYCMDIDECQTPG--ICVNGHCTNTEGSFRCQCLG 600

Query: 457 GWVLAPNGVSC 467
           G  +  +G  C
Sbjct: 601 GLAVGTDGRVC 611



 Score =  126 bits (316), Expect = 7e-29
 Identities = 81/214 (37%), Positives = 99/214 (46%), Gaps = 22/214 (10%)

Query: 264  CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP--CRGGATCVLGP 321
            C   NGGC   C    +GS+ C C  G+ L+ D   CA  + C  +P  C  G  C   P
Sbjct: 1159 CRVQNGGCDVHCINT-EGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGH-CTNMP 1216

Query: 322  HGKNYTCRCPQGYQLDSSQLDCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGP 378
             G  + C C  G+        CVDVDEC  +P  C   +C NT G F C C +GY     
Sbjct: 1217 GG--HRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMV-RK 1273

Query: 379  GEGACQDVDECALGRSPCAQ--GCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPG- 435
            G   C DVDEC +G   C     C N  GSF C C  G+V    DG +C D+DECV    
Sbjct: 1274 GATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWV---GDGFECHDLDECVSQEH 1330

Query: 436  --GPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
               P  D  C N  GS+ C C  G+  A +G  C
Sbjct: 1331 RCSPRGD--CLNVPGSYRCTCRQGF--AGDGFFC 1360



 Score =  125 bits (315), Expect = 9e-29
 Identities = 75/173 (43%), Positives = 93/173 (53%), Gaps = 15/173 (8%)

Query: 304  NPCSSSP--CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQ-DSPCAQ-ECV 359
            N C+ +P  C  G  CV      ++ C CP GY LD + ++CVD DEC    PC Q  C 
Sbjct: 2086 NECAENPGVCTNGV-CV--NTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCT 2142

Query: 360  NTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAG 419
            N  GGF C C  G+EPG      C+D+DEC+L    CA  C NT+GS+ C+C  GY L  
Sbjct: 2143 NVIGGFECACADGFEPGLMM--TCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLR- 2199

Query: 420  EDGTQCQDVDECVGPGGPLCDSL---CFNTQGSFHCGCLPGWVLAP-NGVSCT 468
            EDG  C+DVDEC   G   C +    C N  G+F C C PG    P +G  CT
Sbjct: 2200 EDGAMCRDVDEC-ADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCT 2251



 Score =  124 bits (310), Expect = 4e-28
 Identities = 78/223 (34%), Positives = 102/223 (45%), Gaps = 18/223 (8%)

Query: 252  SSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPC 311
            S G  CV         N   H DC +  +GS++C C  GF+   D   C   + C   PC
Sbjct: 1798 SPGGACVGRNECREIPNVCSHGDCMDT-EGSYMCLCHRGFQASADQTLCMDIDECDRQPC 1856

Query: 312  RGGATC--VLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQD---SPCA-QECVNTPGGF 365
             G  TC  ++G    +Y C C  G+ +  +  DCVD DEC       C    C+NT G F
Sbjct: 1857 -GNGTCKNIIG----SYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSF 1910

Query: 366  RCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQ 424
             C C  G+E    G+  C D +EC      C  G C N +GSF C C  G+ +  +    
Sbjct: 1911 HCLCQDGFELTADGKN-CVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD---H 1966

Query: 425  CQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
            C D+DEC           C N+ GSF C C PG+VL+ NG  C
Sbjct: 1967 CIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRC 2009



 Score =  117 bits (294), Expect = 3e-26
 Identities = 79/215 (36%), Positives = 106/215 (49%), Gaps = 22/215 (10%)

Query: 264  CNFNNGGC-HQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCS--SSPCRGGATCVLG 320
            C+ N   C H DC E   GSF+C C+ G+ +      C+  + C      C   A+C+  
Sbjct: 1242 CDLNPHICLHGDC-ENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNI 1300

Query: 321  PHGKNYTCRCPQGYQLDSSQLDCVDVDEC--QDSPCAQ--ECVNTPGGFRCECWVGYEPG 376
            P   +++CRC  G+  D    +C D+DEC  Q+  C+   +C+N PG +RC C  G+   
Sbjct: 1301 PG--SFSCRCLPGWVGDG--FECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFA-- 1354

Query: 377  GPGEGA-CQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGP 434
              G+G  C+D DECA     C  G C N  G + C CE G+    ED   CQDVDEC   
Sbjct: 1355 --GDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPT-EDHRACQDVDECAQ- 1410

Query: 435  GGPLCD-SLCFNTQGSFHCGCLPGWVLAPNGVSCT 468
             G LC    C N  G F C C  G+ L   G +CT
Sbjct: 1411 -GNLCAFGSCENLPGMFRCICNGGYELDRGGGNCT 1444



 Score =  115 bits (288), Expect = 1e-25
 Identities = 74/193 (38%), Positives = 102/193 (52%), Gaps = 16/193 (8%)

Query: 280  DGSFLCGCR-PGFRLLDDLVTCASRN--PCSSSPCRGGATCVLGPHGKNYTCRCPQGYQL 336
            D   LCG + PGF  L D+ T    +   C   P        +   G ++ C CP G+  
Sbjct: 1698 DYQILCGNQAPGF--LTDIHTGKPLDIDECGEIPAICANGICINQIG-SFRCECPAGFNY 1754

Query: 337  DSSQLDCVDVDEC--QDSPCAQ--ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALG 392
            +S  L C DVDEC  ++SPC Q  +C+N PG +RC+C  GY+   PG GAC   +EC   
Sbjct: 1755 NSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKL-SPG-GACVGRNECREI 1812

Query: 393  RSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFH 451
             + C+ G C +T+GS+ C C  G+  A  D T C D+DEC     P  +  C N  GS++
Sbjct: 1813 PNVCSHGDCMDTEGSYMCLCHRGF-QASADQTLCMDIDEC--DRQPCGNGTCKNIIGSYN 1869

Query: 452  CGCLPGWVLAPNG 464
            C C PG+V+  NG
Sbjct: 1870 CLCFPGFVVTHNG 1882



 Score =  114 bits (286), Expect = 2e-25
 Identities = 85/235 (36%), Positives = 99/235 (42%), Gaps = 46/235 (19%)

Query: 263  GCNFNNGGCHQD---CFEGG----DGSFLCGCRPGFRLLDDLVTCAS--RNPC------- 306
            GC  +N  CH     C  G      GSF C C  GF+    L  C    + PC       
Sbjct: 2249 GCTDDNE-CHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQT 2307

Query: 307  ------SSSPCRGGATCVLG--------------PHGKNYTCRCPQGYQLDSSQLDCVDV 346
                  SSS     A C  G              P    Y   CP G        +  DV
Sbjct: 2308 MCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHG---SGYTAEGRDV 2364

Query: 347  DECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNT 403
            DEC+     CA  EC+N+ G FRC C  GY P       C D+DEC+    PC   C NT
Sbjct: 2365 DECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATAT-TCLDMDECSQVPKPCTFLCKNT 2423

Query: 404  DGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGW 458
             GSF CSC  GY+L  EDG  C+D+DEC       C  LC NT G+F C C PG+
Sbjct: 2424 KGSFLCSCPRGYLLE-EDGRTCKDLDECTSRQHN-CQFLCVNTVGAFTCRCPPGF 2476



 Score =  113 bits (283), Expect = 5e-25
 Identities = 65/155 (41%), Positives = 75/155 (48%), Gaps = 10/155 (6%)

Query: 270  GCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSP-CRGGATCVLGPHGKNYTC 328
            G H  C     GSF C C  GF L+     C   N C     C+ G    LG     Y C
Sbjct: 2497 GAHGHC-HNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLG----GYRC 2551

Query: 329  RCPQGYQLDSSQLDCVDVDECQDSP--CAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQD 385
             CPQG+   S    CVD +EC  SP  C    C NT GGFRC C  G++      G CQ+
Sbjct: 2552 SCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFD-FDQALGGCQE 2610

Query: 386  VDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGE 420
            VDECA  R PC+  C NT G F C C +GY  AG+
Sbjct: 2611 VDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQ 2645



 Score = 96.7 bits (239), Expect = 6e-20
 Identities = 51/111 (45%), Positives = 62/111 (55%), Gaps = 6/111 (5%)

Query: 358 CVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYV 416
           C+ TP  +RCEC VGY     GE  C DVDEC    SPC  G C N  G++HC C  G+ 
Sbjct: 424 CLPTPSSYRCECNVGYTQDVRGE--CIDVDECT--SSPCHHGDCVNIPGTYHCRCYPGFQ 479

Query: 417 LAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
            A      C DVDEC+  GG      C NT+GSF C C  G+ L+P+G +C
Sbjct: 480 -ATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC 529



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 76/237 (32%), Positives = 97/237 (40%), Gaps = 50/237 (21%)

Query: 273  QDCFEGGD------GSFLCGCRPGFRLLDDLVT-CASRNPCSSSP--CRGGATCVLGPHG 323
            QDC   G       G+F C C PG R L      C   N C + P  C  G  CV     
Sbjct: 2216 QDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGR-CV--NTA 2272

Query: 324  KNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNT---------PGGFRCECWVGYE 374
             ++ C C +G+Q   +  +C D+   +  PC  E + T             R EC  G  
Sbjct: 2273 GSFRCDCDEGFQPSPTLTECHDI---RQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGG 2329

Query: 375  PG-GPGEGAC----------------------QDVDECALGRSPCAQG-CTNTDGSFHCS 410
             G GP    C                      +DVDEC +    CA G C N+ GSF C 
Sbjct: 2330 RGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCH 2389

Query: 411  CEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
            C+ GY       T C D+DEC     P C  LC NT+GSF C C  G++L  +G +C
Sbjct: 2390 CQAGYT-PDATATTCLDMDECSQVPKP-CTFLCKNTKGSFLCSCPRGYLLEEDGRTC 2444



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 67/234 (28%), Positives = 92/234 (39%), Gaps = 32/234 (13%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHG 323
           C  + G CH       +GSF C C  GF L  D   C   N C++S       C L   G
Sbjct: 493 CIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVC-LNEDG 551

Query: 324 KNYTCRCPQGYQLDSSQLDCVDVDECQ-DSPCAQ-ECVNTPGGFRCECWVGYEPGGPGEG 381
            +++C C  G+ L      C+D+DECQ    C    C NT G FRC+C  G   G  G  
Sbjct: 552 -SFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGR- 609

Query: 382 ACQDV---DEC--ALGRSPCAQGCTNTDGSFHCSC--------EEGYVLAGEDGTQCQ-- 426
            C D      C  A+ +  CA+    T     C C        E   +   +D  + Q  
Sbjct: 610 VCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQAL 669

Query: 427 ------------DVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCT 468
                       D++EC        + +C N +GS+ C C  G+    +G  CT
Sbjct: 670 CSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCT 723



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 66/237 (27%), Positives = 97/237 (40%), Gaps = 45/237 (18%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGK---NYTCRCPQGYQLD 337
            GSF C C+ GF L  D   C   N C S       TC+ G       ++ C CP G+Q+ 
Sbjct: 1908 GSFHCLCQDGFELTADGKNCVDTNECLSL----AGTCLPGTCQNLEGSFRCICPPGFQVQ 1963

Query: 338  SSQLDCVDVDECQDSP---CAQECVNTPGGFRCECWVGYEPGGPGEGACQ---------- 384
            S    C+D+DEC + P       C N+PG F+C C  G+     G               
Sbjct: 1964 SDH--CIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRF 2021

Query: 385  DVDECALGRS--------------------PCAQGCTNTDGSFHCSCEEGY-VLAGEDGT 423
            +  +C++ ++                    PC         +F   C  G+  + G D +
Sbjct: 2022 EAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDS 2081

Query: 424  QCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCT-MGPVSLGPPSG 479
            + +DV+EC    G   + +C NT GSF C C  G+ L   G++C      S+G P G
Sbjct: 2082 R-EDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCG 2137



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 57/165 (34%), Positives = 74/165 (44%), Gaps = 17/165 (10%)

Query: 271 CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLG---PHGKNYT 327
           CH        G++ C C PGF+       C   + C  S    G  C LG       ++ 
Sbjct: 458 CHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVS----GGLCHLGRCVNTEGSFQ 513

Query: 328 CRCPQGYQLDSSQLDCVDVDECQDSPCAQE--CVNTPGGFRCECWVGYEPGGPGEGACQD 385
           C C  G++L     +CVD +EC  S       C+N  G F C C  G+    PG   C D
Sbjct: 514 CVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLL-APGGHYCMD 572

Query: 386 VDECALGRSP--CAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQD 427
           +DEC   ++P  C  G CTNT+GSF C C  G +  G DG  C D
Sbjct: 573 IDEC---QTPGICVNGHCTNTEGSFRCQCLGG-LAVGTDGRVCVD 613



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 68/208 (32%), Positives = 84/208 (40%), Gaps = 35/208 (16%)

Query: 248 FDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCS 307
           ++ G+SG  C      C  N+  C     +   GS+ C C PGF    D   C   + C 
Sbjct: 713 YEAGASGKDCTDVDE-CALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECL 771

Query: 308 SSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVD------ECQDSPCAQECVNT 361
           SSPC  G    L     +YTC+C  G +LD S   C+D        + Q+S C    VN 
Sbjct: 772 SSPCVSGVCRNL---AGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCE---VNL 825

Query: 362 PG-GFRCEC--WVGYEPGGPGEG-----------------ACQDVDECALGRSPCAQG-C 400
            G   R EC   +G   G P E                   C DV+EC      C  G C
Sbjct: 826 QGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRC 885

Query: 401 TNTDGSFHCSCEEGYVLAGEDGTQCQDV 428
            NT GSF C C EG +L    G  C DV
Sbjct: 886 VNTAGSFRCECPEGLML-DASGRLCVDV 912



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 102/367 (27%), Positives = 134/367 (36%), Gaps = 59/367 (16%)

Query: 165 CGSPG----SPGSNIEGFVCKFSFKGMCRP-LALGGPGQVTYTTPFQTTSSSLEAVPFAS 219
           C +PG       +N EG     SF+  C   LA+G  G+V   T  ++T     A+   S
Sbjct: 576 CQTPGICVNGHCTNTEG-----SFRCQCLGGLAVGTDGRVCVDTHVRSTCYG--AIEKGS 628

Query: 220 AANVACGEGDKDE----TQSHYF-----LCKEKAPDVFDWGSSGPLCVSPK----YGCNF 266
            A    G   K E       H F     LC  K    F    S  L ++        C  
Sbjct: 629 CARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECAL 688

Query: 267 NNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCS--SSPCRGGATCVLGPHGK 324
           +   C     E   GS+ C C  G+        C   + C+  S  C  G  C   P   
Sbjct: 689 DPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNG-WCQNSPG-- 745

Query: 325 NYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQE-CVNTPGGFRCECWVG--YEPGGP--- 378
           +Y+C CP G+        C DVDEC  SPC    C N  G + C+C  G   +P G    
Sbjct: 746 SYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCL 805

Query: 379 -----------GEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYV-------LAGE 420
                       E  C+   + A  RS C   C     ++   CE   +        A  
Sbjct: 806 DSTKGTCWLKIQESRCEVNLQGASLRSEC---CATLGAAWGSPCERCEIDPACARGFARM 862

Query: 421 DGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGP 480
            G  C DV+EC    G   +  C NT GSF C C  G +L  +G  C    V L P    
Sbjct: 863 TGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCV--DVRLEPCFLR 920

Query: 481 PDEEDKG 487
            DE++ G
Sbjct: 921 WDEDECG 927



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 65/225 (28%), Positives = 86/225 (38%), Gaps = 41/225 (18%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQ 340
            G F C C  G+ L      C   N C+         C+  P   +Y C CPQ ++L+ S 
Sbjct: 1424 GMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPG--SYLCSCPQDFELNPSG 1481

Query: 341  LDCVDVD------ECQDS-----PCAQECVNTPGGFRCECWVGYEPGGP----------- 378
            + CVD        E  D       C+ E         C C +G   G P           
Sbjct: 1482 VGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTE 1541

Query: 379  -------GEG--------ACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDG 422
                   GEG          +D+DEC      C  G C NT GSF C C  GY L+ E  
Sbjct: 1542 YRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLS-EHT 1600

Query: 423  TQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
              C+D+DEC    G      C+NT G++ C C   ++    G +C
Sbjct: 1601 RICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNC 1645



 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 73/237 (30%), Positives = 94/237 (39%), Gaps = 59/237 (24%)

Query: 277  EGGD-----GSFLCGCRPGFRLLDDLVTCASRNPCSS-SPCRGGATC--VLGPHGKNYTC 328
            +GGD     GSF C C PG+ L +    C   + CS+ S   G  TC   LG    NYTC
Sbjct: 1575 QGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLG----NYTC 1630

Query: 329  RCPQGYQLDSSQLDCVDVDE----------CQDS---------PCAQECVNTPGGFRCE- 368
             CP  Y   +   +C+D+ +          CQ+           C    +       CE 
Sbjct: 1631 VCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEA 1690

Query: 369  CWVGYEPG--------GPG------EGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEE 413
            C     P          PG       G   D+DEC    + CA G C N  GSF C C  
Sbjct: 1691 CPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPA 1750

Query: 414  GY-----VLAGEDGTQCQDVDECVGPGGPLCDSL-CFNTQGSFHCGCLPGWVLAPNG 464
            G+     +LA      C+DVDEC     P   +  C N  GS+ C C  G+ L+P G
Sbjct: 1751 GFNYNSILLA------CEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGG 1801



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 47/132 (35%), Positives = 58/132 (43%), Gaps = 15/132 (11%)

Query: 258  VSPKYGCNFNNG-----GCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCS-SSPC 311
            VS  +GC   N       C   C +   G + C C  GF        C   N C+ S P 
Sbjct: 2520 VSSGHGCEDVNECDGPHRCQHGC-QNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPT 2578

Query: 312  RGGATC--VLGPHGKNYTCRCPQGYQLDSSQLDCVDVDEC--QDSPCAQECVNTPGGFRC 367
             G A+C   LG     + C CP G+  D +   C +VDEC  +  PC+  C NTPGGF C
Sbjct: 2579 CGSASCRNTLG----GFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLC 2634

Query: 368  ECWVGYEPGGPG 379
             C  GY   G G
Sbjct: 2635 GCPQGYFRAGQG 2646



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 74/285 (25%), Positives = 92/285 (32%), Gaps = 70/285 (24%)

Query: 169 GSPGSNIEGFVCKFSFKGMCRPLALGGPGQVTYTTPFQTTSSSLEAVPFASAANVACGEG 228
           GSPG      VC   F   C P     PG+     P                   ACGEG
Sbjct: 49  GSPGILQGPNVCGSRFHAYCCPGWRTFPGRSQCVVPI---------------CRRACGEG 93

Query: 229 DKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGD-GSFLCGC 287
               +Q +   C +        G+  P C   +        GC   C  GG      C C
Sbjct: 94  FC--SQPNLCTCAD--------GTLAPSCGVSR------GSGCSVSCMNGGTCRGASCLC 137

Query: 288 RPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDC---- 343
           + G+             P     C  G  C+ GP+     C C  G+     + D     
Sbjct: 138 QKGY------TGTVCGQPICDRGCHNGGRCI-GPN----RCACVYGFMGPQCERDYRTGP 186

Query: 344 ----VDVDECQDSPCAQEC--------VNTPGGFRCE--------CWVGYEPGGPGEGAC 383
               V  + CQ       C        V    G  CE        C  G+ P     GAC
Sbjct: 187 CFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPN-IHTGAC 245

Query: 384 QDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQD 427
           QDVDEC      C  G C N  GSFHC C  G+ L+ +    C+D
Sbjct: 246 QDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLS-DSSAACED 289



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 58/219 (26%), Positives = 73/219 (33%), Gaps = 59/219 (26%)

Query: 287 CRPGFRLLDDLVTCA----------SRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQL 336
           C  GF    +L TCA          SR    S  C  G TC      +  +C C +GY  
Sbjct: 90  CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTC------RGASCLCQKGYT- 142

Query: 337 DSSQLDCVDVDECQDSPCAQECVNTP---GGFRCECWVG---------YEPG------GP 378
                       C    C + C N     G  RC C  G         Y  G      GP
Sbjct: 143 ---------GTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGP 193

Query: 379 GEGACQDVDECALGRSPCAQGCTNTDGSFHCSCE----------EGYVLAGEDGTQCQDV 428
            EG    +      ++ C   C     ++   CE           G++     G  CQDV
Sbjct: 194 -EGCQHQLTGLVCTKALC---CATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGA-CQDV 248

Query: 429 DECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
           DEC    G      C N  GSFHC C  G  L+ +  +C
Sbjct: 249 DECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC 287


>gi|190343004 EGF-containing fibulin-like extracellular matrix
           protein 2 [Homo sapiens]
          Length = 443

 Score =  130 bits (326), Expect = 5e-30
 Identities = 71/176 (40%), Positives = 93/176 (52%), Gaps = 11/176 (6%)

Query: 287 CRPGFRLLDDLVTCASRNPCSSS--PCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCV 344
           C PG+   DD  +C   + C+ +   CR    C   P   +Y C CP GY+    +  CV
Sbjct: 109 CPPGYEP-DDQDSCVDVDECAQALHDCRPSQDCHNLPG--SYQCTCPDGYRKIGPE--CV 163

Query: 345 DVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTD 404
           D+DEC+   C   CVN PG FRC+C  G++  GP   +C DV+EC +G +PC Q C N+ 
Sbjct: 164 DIDECRYRYCQHRCVNLPGSFRCQCEPGFQL-GPNNRSCVDVNECDMG-APCEQRCFNSY 221

Query: 405 GSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVL 460
           G+F C C +GY L   DG  C D+DEC      LC   C N  G F C C  G+ L
Sbjct: 222 GTFLCRCHQGYEL-HRDGFSCSDIDEC-SYSSYLCQYRCVNEPGRFSCHCPQGYQL 275



 Score =  113 bits (283), Expect = 5e-25
 Identities = 75/215 (34%), Positives = 94/215 (43%), Gaps = 44/215 (20%)

Query: 287 CRPGFRLLDDLVTCASRNPCSSSP--CRGGATCVLGPHGKNYTCR--------------- 329
           C  G+    D   C   N C + P  C+G   C+   H   Y C                
Sbjct: 39  CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCI--NHYGGYLCLPRSAAVINDLHGEGP 96

Query: 330 ------------CPQGYQLDSSQLDCVDVDEC----QDSPCAQECVNTPGGFRCECWVGY 373
                       CP GY+ D  Q  CVDVDEC     D   +Q+C N PG ++C C  GY
Sbjct: 97  PPPVPPAQHPNPCPPGYEPDD-QDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGY 155

Query: 374 EPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVG 433
              GP    C D+DEC      C   C N  GSF C CE G+ L G +   C DV+EC  
Sbjct: 156 RKIGP---ECVDIDECRYRY--CQHRCVNLPGSFRCQCEPGFQL-GPNNRSCVDVNEC-D 208

Query: 434 PGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCT 468
            G P C+  CFN+ G+F C C  G+ L  +G SC+
Sbjct: 209 MGAP-CEQRCFNSYGTFLCRCHQGYELHRDGFSCS 242



 Score =  100 bits (248), Expect = 5e-21
 Identities = 58/154 (37%), Positives = 70/154 (45%), Gaps = 15/154 (9%)

Query: 281 GSFLCGCRPGFRLLDDLVTCASRNPCS-SSPCRGGATCVLGPHGKNYTCRCPQGYQLDSS 339
           GSF C C PGF+L  +  +C   N C   +PC        G     + CRC QGY+L   
Sbjct: 182 GSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYG----TFLCRCHQGYELHRD 237

Query: 340 QLDCVDVDECQDSP--CAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPC- 396
              C D+DEC  S   C   CVN PG F C C  GY+        CQD+DEC  G   C 
Sbjct: 238 GFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQL--LATRLCQDIDECESGAHQCS 295

Query: 397 -AQGCTNTDGSFHC----SCEEGYVLAGEDGTQC 425
            AQ C N  G + C     C E Y+   E+   C
Sbjct: 296 EAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLC 329



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 63/187 (33%), Positives = 81/187 (43%), Gaps = 43/187 (22%)

Query: 325 NYTCRCPQGYQLDSSQLDCVDVDECQDSPCA----QECVNTPGGFRC------------- 367
           +YT  C  GY+ D     C DV+EC   P A     +C+N  GG+ C             
Sbjct: 35  SYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHG 93

Query: 368 --------------ECWVGYEPGGPGEGACQDVDECALGRSPC--AQGCTNTDGSFHCSC 411
                          C  GYEP    + +C DVDECA     C  +Q C N  GS+ C+C
Sbjct: 94  EGPPPPVPPAQHPNPCPPGYEPDD--QDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTC 151

Query: 412 EEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCT-MG 470
            +GY    + G +C D+DEC       C   C N  GSF C C PG+ L PN  SC  + 
Sbjct: 152 PDGY---RKIGPECVDIDEC---RYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVN 205

Query: 471 PVSLGPP 477
              +G P
Sbjct: 206 ECDMGAP 212



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 43/101 (42%), Positives = 56/101 (55%), Gaps = 8/101 (7%)

Query: 271 CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRC 330
           C Q CF    G+FLC C  G+ L  D  +C+  + CS S       CV  P    ++C C
Sbjct: 213 CEQRCFNSY-GTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEP--GRFSCHC 269

Query: 331 PQGYQLDSSQLDCVDVDECQDS--PC--AQECVNTPGGFRC 367
           PQGYQL +++L C D+DEC+     C  AQ CVN  GG+RC
Sbjct: 270 PQGYQLLATRL-CQDIDECESGAHQCSEAQTCVNFHGGYRC 309


>gi|10190748 CEGP1 protein [Homo sapiens]
          Length = 999

 Score =  128 bits (322), Expect = 1e-29
 Identities = 84/246 (34%), Positives = 111/246 (45%), Gaps = 40/246 (16%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC--------SSSPCRGGA 315
           CN  NGGC   C +  DG   C C P +++  D  +C  R           ++S   G  
Sbjct: 217 CNHGNGGCQHSCDDTADGPE-CSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDK 275

Query: 316 ---------TCVLGPHGKNYTCR---------CPQGYQLDSSQLDCVDVDECQ--DSPCA 355
                    TC +   G + TC+         CP G+ L      C D+DECQ  +  C 
Sbjct: 276 RVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCD 335

Query: 356 QECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGY 415
             C N  G F C C  G++     E +CQDVDEC+L R+ C   C N  G+F C+C  GY
Sbjct: 336 HFCKNIVGSFDCGCKKGFKLL-TDEKSCQDVDECSLDRT-CDHSCINHPGTFACACNRGY 393

Query: 416 VLAGEDGTQCQDVDEC-VGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCT----MG 470
            L G   T C D +EC +  GG  C  +C NT GS+ C C PG+ L  N   C     + 
Sbjct: 394 TLYGF--THCGDTNECSINNGG--CQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLL 449

Query: 471 PVSLGP 476
           P S+ P
Sbjct: 450 PTSVSP 455



 Score =  109 bits (272), Expect = 9e-24
 Identities = 71/235 (30%), Positives = 93/235 (39%), Gaps = 35/235 (14%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNP----CSSSPCRGGATCVL 319
           C  NNGGC   C     GS+ C C+ GF L D+  TC  R+     C +        C  
Sbjct: 132 CLENNGGCQHTCVNVM-GSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKE 190

Query: 320 GPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPG 379
            P G +  C C  G++L  +Q DC+      +  C   C +T  G  C C   Y+    G
Sbjct: 191 APRG-SVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDG 249

Query: 380 EGACQDVD---------------------------ECALGRSPCAQGCTNTDGSFHCSCE 412
               +  D                            CA+    C + C +T    HCSC 
Sbjct: 250 RSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCP 309

Query: 413 EGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
            G+ L   DG  C+D+DEC    G  CD  C N  GSF CGC  G+ L  +  SC
Sbjct: 310 VGFTLQ-LDGKTCKDIDECQTRNGG-CDHFCKNIVGSFDCGCKKGFKLLTDEKSC 362



 Score =  106 bits (264), Expect = 8e-23
 Identities = 66/191 (34%), Positives = 87/191 (45%), Gaps = 15/191 (7%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHG 323
           C  NNGGC + C +   G   C C  GF L  D  TC   + C +    GG         
Sbjct: 286 CAVNNGGCDRTCKDTSTGVH-CSCPVGFTLQLDGKTCKDIDECQTR--NGGCDHFCKNIV 342

Query: 324 KNYTCRCPQGYQLDSSQLDCVDVDECQ-DSPCAQECVNTPGGFRCECWVGYEPGGPGEGA 382
            ++ C C +G++L + +  C DVDEC  D  C   C+N PG F C C  GY   G     
Sbjct: 343 GSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACNRGYTLYGFTH-- 400

Query: 383 CQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSL 442
           C D +EC++    C Q C NT GS+ C C  GY L         +  +CV   G L  S+
Sbjct: 401 CGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLH-------WNKKDCVEVKGLLPTSV 453

Query: 443 CFNTQGSFHCG 453
             + + S HCG
Sbjct: 454 --SPRVSLHCG 462



 Score =  100 bits (250), Expect = 3e-21
 Identities = 58/172 (33%), Positives = 77/172 (44%), Gaps = 25/172 (14%)

Query: 311 CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDS---PCAQECVNTPGGFRC 367
           C   A C   P   +Y C C  GYQ +  Q  C D+DEC +     C  +C+N PG +RC
Sbjct: 56  CHADALCQNTP--TSYKCSCKPGYQGEGRQ--CEDIDECGNELNGGCVHDCLNIPGNYRC 111

Query: 368 ECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLA--------- 418
            C+ G+     G   C DVDEC      C   C N  GS+ C C+EG+ L+         
Sbjct: 112 TCFDGFMLAHDGHN-CLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHR 170

Query: 419 GEDGTQCQDVDECVGPGGPLCDSLCFNT-QGSFHCGCLPGWVLAPNGVSCTM 469
            E+G  C + D         C  +C    +GS  C C PG+ LA N   C +
Sbjct: 171 SEEGLSCMNKDHG-------CSHICKEAPRGSVACECRPGFELAKNQRDCIL 215



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 50/140 (35%), Positives = 70/140 (50%), Gaps = 23/140 (16%)

Query: 330 CPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEG-ACQDVDE 388
           C QG  LD    D +    CQ++P +         ++C C    +PG  GEG  C+D+DE
Sbjct: 49  CAQG--LDDCHADAL----CQNTPTS---------YKCSC----KPGYQGEGRQCEDIDE 89

Query: 389 CALG-RSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQ 447
           C       C   C N  G++ C+C +G++LA  DG  C DVDEC+   G  C   C N  
Sbjct: 90  CGNELNGGCVHDCLNIPGNYRCTCFDGFMLA-HDGHNCLDVDECLENNGG-CQHTCVNVM 147

Query: 448 GSFHCGCLPGWVLAPNGVSC 467
           GS+ C C  G+ L+ N  +C
Sbjct: 148 GSYECCCKEGFFLSDNQHTC 167



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 41/96 (42%), Positives = 52/96 (54%), Gaps = 6/96 (6%)

Query: 375 PG-GPGEGACQDVDECALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC 431
           PG G   G  +DVDECA G   C     C NT  S+ CSC+ GY   GE G QC+D+DEC
Sbjct: 34  PGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGE-GRQCEDIDEC 90

Query: 432 VGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
                  C   C N  G++ C C  G++LA +G +C
Sbjct: 91  GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNC 126



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 61/223 (27%), Positives = 85/223 (38%), Gaps = 52/223 (23%)

Query: 271 CHQDCF-EGGDGSFLCGCRPGF----RLLDDLVTCASRNPCSSSPCRGGAT--CVLGPHG 323
           CH D   +    S+ C C+PG+    R  +D+  C +          GG    C+  P  
Sbjct: 56  CHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNE-------LNGGCVHDCLNIP-- 106

Query: 324 KNYTCRCPQGYQLDSSQLDCVDVDEC--QDSPCAQECVNTPGGFRCECWVGYEPGGPGEG 381
            NY C C  G+ L     +C+DVDEC   +  C   CVN  G + C C  G+        
Sbjct: 107 GNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGF-------- 158

Query: 382 ACQDVDECALGRSPCAQGCTNTD------------GSFHCSCEEGYVLAGEDGTQCQDVD 429
              D     + RS     C N D            GS  C C  G+ LA       ++  
Sbjct: 159 FLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELA-------KNQR 211

Query: 430 ECV-----GPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
           +C+     G GG  C   C +T     C C P + +  +G SC
Sbjct: 212 DCILTCNHGNGG--CQHSCDDTADGPECSCHPQYKMHTDGRSC 252


>gi|4557733 latent transforming growth factor beta binding protein 2
            [Homo sapiens]
          Length = 1821

 Score =  128 bits (321), Expect = 2e-29
 Identities = 84/207 (40%), Positives = 110/207 (53%), Gaps = 19/207 (9%)

Query: 269  GGCHQDCFEGGDGSFLC-GCRPGFRLLDDLVTCASRNPCSS--SPCRGG-ATCVLGPHGK 324
            G C         GSF C  C  G+R      +C   + C    S C GG     +G    
Sbjct: 1101 GVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVG---- 1156

Query: 325  NYTCRCPQGYQLDSSQLDCVDVDECQ-DSPCAQ--ECVNTPGGFRCECWVGYEPGGPGEG 381
            +Y C CPQG+QL +  + C DV+EC  +  CA   EC+N+ G F C C  G+     G  
Sbjct: 1157 SYQCLCPQGFQLANGTV-CEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFV-SAEGGT 1214

Query: 382  ACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCD 440
            +CQDVDECA    PC  G C NT+GSF+C CE G+  + E G +C D+DEC   G P+C 
Sbjct: 1215 SCQDVDECAT-TDPCVGGHCVNTEGSFNCLCETGFQPSPESG-ECVDIDECEDYGDPVCG 1272

Query: 441  S-LCFNTQGSFHC--GCLPGWVLAPNG 464
            +  C N+ GS+ C  GC PG+ +APNG
Sbjct: 1273 TWKCENSPGSYRCVLGCQPGFHMAPNG 1299



 Score =  127 bits (318), Expect = 4e-29
 Identities = 86/195 (44%), Positives = 106/195 (54%), Gaps = 17/195 (8%)

Query: 280  DGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTC-RCPQGYQLDS 338
            +GS+ C C  G+ ++     C   N C          CV  P   +YTC  C +GY+  S
Sbjct: 949  EGSYHCECDQGYIMVRK-GHCQDINECRHPGTCPDGRCVNSPG--SYTCLACEEGYRGQS 1005

Query: 339  SQLDCVDVDEC-QDSPCAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPC 396
                CVDV+EC     CA  +C N  G FRC C  GYE     +G CQDVDECA  R+ C
Sbjct: 1006 GS--CVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKG-CQDVDECA-SRASC 1061

Query: 397  AQG-CTNTDGSFHCS-CEEGYVLAGEDGTQCQDVDECVGPGGPLCDS-LCFNTQGSFHC- 452
              G C NT+GSF CS CE GY +  EDGT C+D+DEC  PG  +C S +C NT GSF C 
Sbjct: 1062 PTGLCLNTEGSFACSACENGYWV-NEDGTACEDLDECAFPG--VCPSGVCTNTAGSFSCK 1118

Query: 453  GCLPGWVLAPNGVSC 467
             C  G+  +P G SC
Sbjct: 1119 DCDGGYRPSPLGDSC 1133



 Score =  121 bits (304), Expect = 2e-27
 Identities = 84/238 (35%), Positives = 109/238 (45%), Gaps = 52/238 (21%)

Query: 275  CFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGY 334
            C    DG + C C PG++L      C   N C   PC+G   C+      +Y+C C  GY
Sbjct: 861  CVNLPDG-YRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCI--NRVGSYSCFCYPGY 917

Query: 335  QLDSS--QLDCVDVDEC-QDSPCA-QECVNTPGGFRCECWVGY---------------EP 375
             L +S    +C D++EC Q   C+  +C NT G + CEC  GY                P
Sbjct: 918  TLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHP 977

Query: 376  G---------GPG--------------EGACQDVDECALGRSPCAQG-CTNTDGSFHCSC 411
            G          PG               G+C DV+EC L    CA G CTN +GSF CSC
Sbjct: 978  GTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNEC-LTPGVCAHGKCTNLEGSFRCSC 1036

Query: 412  EEGYVLAGEDGTQCQDVDECVGPGGPLCDS-LCFNTQGSFHC-GCLPGWVLAPNGVSC 467
            E+GY +   D   CQDVDEC       C + LC NT+GSF C  C  G+ +  +G +C
Sbjct: 1037 EQGYEVT-SDEKGCQDVDECASRAS--CPTGLCLNTEGSFACSACENGYWVNEDGTAC 1091



 Score =  112 bits (281), Expect = 8e-25
 Identities = 73/196 (37%), Positives = 94/196 (47%), Gaps = 17/196 (8%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSP-CRGGATCVLGPHGKNYTCRCPQGYQLDSS 339
            GS+ C C  GF+L +  V C   N C     C     C L  HG ++ C C  G+     
Sbjct: 1156 GSYQCLCPQGFQLANGTV-CEDVNECMGEEHCAPHGEC-LNSHG-SFFCLCAPGFVSAEG 1212

Query: 340  QLDCVDVDECQDS-PCAQ-ECVNTPGGFRCECWVGYEPGGPGEGACQDVDECA-LGRSPC 396
               C DVDEC  + PC    CVNT G F C C  G++P  P  G C D+DEC   G   C
Sbjct: 1213 GTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPS-PESGECVDIDECEDYGDPVC 1271

Query: 397  AQG-CTNTDGSFHC--SCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS--LCFNTQGSFH 451
                C N+ GS+ C   C+ G+ +A      C D+DEC      +C S   C NT GSF 
Sbjct: 1272 GTWKCENSPGSYRCVLGCQPGFHMAPNG--DCIDIDECAND--TMCGSHGFCDNTDGSFR 1327

Query: 452  CGCLPGWVLAPNGVSC 467
            C C  G+ ++P+G  C
Sbjct: 1328 CLCDQGFEISPSGWDC 1343



 Score =  112 bits (279), Expect = 1e-24
 Identities = 61/157 (38%), Positives = 80/157 (50%), Gaps = 12/157 (7%)

Query: 311  CRGGATCVLGPHG-----KNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQE--CVNTPG 363
            C  GAT V GP         Y C C  GYQL  SQ  C D +EC   PC  +  C+N  G
Sbjct: 848  CAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVG 907

Query: 364  GFRCECWVGYEPGGPGEGA-CQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDG 422
             + C C+ GY     G    CQD++EC          CTNT+GS+HC C++GY++  +  
Sbjct: 908  SYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG- 966

Query: 423  TQCQDVDECVGPGGPLCDSLCFNTQGSFHC-GCLPGW 458
              CQD++EC  P G   D  C N+ GS+ C  C  G+
Sbjct: 967  -HCQDINECRHP-GTCPDGRCVNSPGSYTCLACEEGY 1001



 Score =  108 bits (271), Expect = 1e-23
 Identities = 78/211 (36%), Positives = 94/211 (44%), Gaps = 26/211 (12%)

Query: 269  GGCHQDCFEGGDGSFLC-GCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGK--- 324
            G C         GS+ C  C  G+R      +C   N C +        C    HGK   
Sbjct: 978  GTCPDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVNECLTP-----GVCA---HGKCTN 1027

Query: 325  ---NYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQE--CVNTPGGFRCE-CWVGYEPGGP 378
               ++ C C QGY++ S +  C DVDEC          C+NT G F C  C  GY     
Sbjct: 1028 LEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNED 1087

Query: 379  GEGACQDVDECALGRSPCAQG-CTNTDGSFHC-SCEEGYVLAGEDGTQCQDVDECVGPGG 436
            G  AC+D+DECA     C  G CTNT GSF C  C+ GY      G  C+DVDEC  P  
Sbjct: 1088 GT-ACEDLDECAFP-GVCPSGVCTNTAGSFSCKDCDGGY-RPSPLGDSCEDVDECEDPQS 1144

Query: 437  PLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
                  C NT GS+ C C  G+ LA NG  C
Sbjct: 1145 SCLGGECKNTVGSYQCLCPQGFQLA-NGTVC 1174



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 63/243 (25%), Positives = 86/243 (35%), Gaps = 63/243 (25%)

Query: 277  EGGDGSFLC--GCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGY 334
            E   GS+ C  GC+PGF +  +   C   + C++    G         G ++ C C QG+
Sbjct: 1277 ENSPGSYRCVLGCQPGFHMAPN-GDCIDIDECANDTMCGSHGFCDNTDG-SFRCLCDQGF 1334

Query: 335  QLDSSQLDCVDVDECQD--SPC-AQECVNTPGGFRCECWVGYEPGGPGEGAC-------Q 384
            ++  S  DCVDV+EC+   + C A  C N  G F C C    E     EG C       Q
Sbjct: 1335 EISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQ 1394

Query: 385  DVDECALG-----------------RSPCAQGCTNTDGSFHCSCEEGY-------VLAGE 420
             + E   G                  +PC+           C C +G        +   E
Sbjct: 1395 SMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSE 1454

Query: 421  DG------------------------TQCQDVDECVGPGGPLC-DSLCFNTQGSFHCGCL 455
            D                         T   D DECV  G  LC +  C NT   + C C 
Sbjct: 1455 DSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCN 1514

Query: 456  PGW 458
            PG+
Sbjct: 1515 PGF 1517



 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 77/270 (28%), Positives = 97/270 (35%), Gaps = 55/270 (20%)

Query: 220  AANVACGE-GDKDETQSHY-FLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFE 277
            A +  CG  G  D T   +  LC +     F+   SG  CV     C      C     E
Sbjct: 1308 ANDTMCGSHGFCDNTDGSFRCLCDQG----FEISPSGWDCVDVNE-CELMLAVCGAALCE 1362

Query: 278  GGDGSFLCGCRPGFRLLD----------------------DLVTCASRNPCSSSPCRGGA 315
              +GSFLC C       D                      D     +R  C S   +G A
Sbjct: 1363 NVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQ-KGHA 1421

Query: 316  TC--VLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGY 373
             C  VLG +     C C QG    +S  D  D+   +DS    E         C    GY
Sbjct: 1422 PCSSVLGRNTTQAECCCTQG----ASWGDACDLCPSEDSAEFSEI--------CPSGKGY 1469

Query: 374  EPGGP----GEGACQDVDECAL-GRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQD 427
             P       G+    D DEC + G   C  G C NT   + C C  G+        +C+D
Sbjct: 1470 IPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASH-KKCED 1528

Query: 428  VDECVGPGGPLCDS-LCFNTQGSFHCGCLP 456
             DEC       C++  C NT+GSFHC C P
Sbjct: 1529 HDECQDLA---CENGECVNTEGSFHCFCSP 1555



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 28/63 (44%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 324  KNYTCRCPQGYQLDSSQLDCVDVDECQD--SPCA----QECVNTPGGFRCECWVGY--EP 375
            + YTC C +G+QLD++ + CVDV+EC D   P        C NT G +RC C  GY  E 
Sbjct: 1753 EGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEA 1812

Query: 376  GGP 378
            G P
Sbjct: 1813 GPP 1815



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 48/194 (24%), Positives = 65/194 (33%), Gaps = 32/194 (16%)

Query: 185  KGMCRPLALGGPGQVTYTTPFQTTSSSLEAVPFASAANVACGEGDKDETQSHYFLCKEKA 244
            +G CRP   GG       T     + +          +  C       T      C + A
Sbjct: 1383 EGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGA 1442

Query: 245  PDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRN 304
                 WG +  LC S                 +  + S +C    G+  ++   T     
Sbjct: 1443 ----SWGDACDLCPSE----------------DSAEFSEICPSGKGYIPVEGAWTFGQTM 1482

Query: 305  PCSSSPCR--GGATCVLGPHGK------NYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQ 356
               +  C   G   C   P+G+       Y C C  G+  D+S   C D DECQD  C  
Sbjct: 1483 YTDADECVIFGPGLC---PNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACEN 1539

Query: 357  -ECVNTPGGFRCEC 369
             ECVNT G F C C
Sbjct: 1540 GECVNTEGSFHCFC 1553



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 37/120 (30%), Positives = 55/120 (45%), Gaps = 13/120 (10%)

Query: 301  ASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVN 360
            A R P   SP +      L PH        P G++   ++ +C  ++ C++      CV 
Sbjct: 1699 ADRTPILESPLQPSE---LQPHYVASHPEPPAGFEGLQAE-ECGILNGCENG----RCVR 1750

Query: 361  TPGGFRCECWVGYEPGGPGEGACQDVDECALGRSP---CAQG-CTNTDGSFHCSCEEGYV 416
               G+ C+C+ G++       AC DV+EC     P   C  G C NT+GS+ C C  GYV
Sbjct: 1751 VREGYTCDCFEGFQLDA-AHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYV 1809



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 34/103 (33%), Positives = 44/103 (42%), Gaps = 6/103 (5%)

Query: 370  WVGYEPGGPGEGACQDVDECALGRSPCAQG-CTNTDGSFHCSCEEGYVLAGEDGTQCQDV 428
            +V   P  P        +EC +  + C  G C      + C C EG+ L       C DV
Sbjct: 1718 YVASHPEPPAGFEGLQAEECGI-LNGCENGRCVRVREGYTCDCFEGFQLDAAH-MACVDV 1775

Query: 429  DECVGPGGP--LC-DSLCFNTQGSFHCGCLPGWVLAPNGVSCT 468
            +EC    GP  LC    C NT+GS+ C C PG+V       CT
Sbjct: 1776 NECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCT 1818



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 25/58 (43%), Positives = 34/58 (58%), Gaps = 5/58 (8%)

Query: 411 CEEGYVLAGEDGTQCQDVDECVGPGGPLC-DSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
           C +GY       T CQD++EC+  G  LC D+ C NT+GS+ C C PG +L P+   C
Sbjct: 608 CPQGYKRLNL--THCQDINECLTLG--LCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 60/254 (23%), Positives = 86/254 (33%), Gaps = 50/254 (19%)

Query: 265 NFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGK 324
           N  NG C     E       CG    F     +  CA   PC   P          P  +
Sbjct: 557 NTVNGQCANPLLELTTQEDCCGSVGAFW---GVTLCA---PCPPRPA--------SPVIE 602

Query: 325 NYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQ--ECVNTPGGFRCECWVGYEPG---GPG 379
           N    CPQGY+   +   C D++EC      +  ECVNT G + C C     PG    P 
Sbjct: 603 NGQLECPQGYKR-LNLTHCQDINECLTLGLCKDAECVNTRGSYLCTC----RPGLMLDPS 657

Query: 380 EGAC---------QDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDE 430
              C         Q +   +LG   C            C C     +    G++C   ++
Sbjct: 658 RSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSR---VGKAWGSEC---EK 711

Query: 431 CVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGPPDEEDKGEKE 490
           C  PG      +C     + H     G+  A + +  +M        + PP E+  G++ 
Sbjct: 712 CPLPGTEAFREIC----PAGH-----GYTYASSDIRLSMRKAEEEELARPPREQ--GQRS 760

Query: 491 GSTVPRAATASPTR 504
              +P  A   P R
Sbjct: 761 SGALPGPAERQPLR 774



 Score = 33.5 bits (75), Expect = 0.63
 Identities = 39/171 (22%), Positives = 55/171 (32%), Gaps = 35/171 (20%)

Query: 195  GPGQVTYT------TPFQTTSSSLEAVPFASAANVACGEGDK----------DETQSHYF 238
            GP  + Y+       PF       + VP  +  N A    D+           E Q HY 
Sbjct: 1660 GPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYV 1719

Query: 239  LCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLV 298
                + P  F+   +          C   NG  +  C    +G + C C  GF+L    +
Sbjct: 1720 ASHPEPPAGFEGLQAEE--------CGILNGCENGRCVRVREG-YTCDCFEGFQLDAAHM 1770

Query: 299  TCASRNPCSSSPCRGGATCVLGPHG------KNYTCRCPQGYQLDSSQLDC 343
             C   N C           VL  HG       +Y C C  GY  ++    C
Sbjct: 1771 ACVDVNECDDL----NGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817



 Score = 30.8 bits (68), Expect = 4.1
 Identities = 13/42 (30%), Positives = 18/42 (42%), Gaps = 1/42 (2%)

Query: 428 VDECVGPGGPLCD-SLCFNTQGSFHCGCLPGWVLAPNGVSCT 468
           +D C      +C    C N    + C C PG+ L P+   CT
Sbjct: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCT 886


>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
          Length = 1184

 Score =  127 bits (319), Expect = 3e-29
 Identities = 82/207 (39%), Positives = 107/207 (51%), Gaps = 30/207 (14%)

Query: 281 GSFLCG----CRPGFRLLDDLVTCASRNPCSS--SPCRGGATCV--LGPHGKNYTCR--- 329
           GSF C     C  GF L D    C   N C+S   PCR G +C+  +G    +YTC+   
Sbjct: 786 GSFYCQARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFSCINTVG----SYTCQRNP 840

Query: 330 --CPQGYQLDSSQLDCVDVDECQDSP--CA--QECVNTPGGFRCECWVGYEPGGPGEGAC 383
             C +GY        CVDV+EC+     C   Q C N PG +RC+C  G++    G G C
Sbjct: 841 LICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRG-C 899

Query: 384 QDVDEC--ALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS 441
            DV+EC  + GR  C   C NT GS+ CSC  G++LA  DG +C+DV+EC       C  
Sbjct: 900 IDVNECWASPGRL-CQHTCENTLGSYRCSCASGFLLAA-DGKRCEDVNECEAQR---CSQ 954

Query: 442 LCFNTQGSFHCGCLPGWVLAPNGVSCT 468
            C N  GS+ C C  G+ LA +G +CT
Sbjct: 955 ECANIYGSYQCYCRQGYQLAEDGHTCT 981



 Score =  117 bits (293), Expect = 3e-26
 Identities = 70/188 (37%), Positives = 93/188 (49%), Gaps = 15/188 (7%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSP---CRGGATCVLGPHGKNYTCRCPQGYQLD 337
            GS+ C C+ GF+       C   N C +SP   C+      LG    +Y C C  G+ L 
Sbjct: 880  GSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLG----SYRCSCASGFLLA 935

Query: 338  SSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRS-PC 396
            +    C DV+EC+   C+QEC N  G ++C C  GY+    G   C D+DECA G    C
Sbjct: 936  ADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGH-TCTDIDECAQGAGILC 994

Query: 397  AQGCTNTDGSFHCSC-EEGYVLAGEDGTQCQDVDEC-VGPGGPLCDSLCFNTQGSFHC-- 452
               C N  GS+ C+C E+GY +   +G  C+DVDEC +G         C N QGSF C  
Sbjct: 995  TFRCLNVPGSYQCACPEQGYTMTA-NGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLR 1053

Query: 453  -GCLPGWV 459
              C P +V
Sbjct: 1054 FECPPNYV 1061



 Score =  112 bits (281), Expect = 8e-25
 Identities = 78/261 (29%), Positives = 104/261 (39%), Gaps = 64/261 (24%)

Query: 267 NNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC-------------------- 306
           +NG C Q C   G GS +C C PG+ ++ D V+C   N C                    
Sbjct: 685 DNGPCKQVCSTVG-GSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSF 743

Query: 307 --------------SSSPCRGGATCVLGPHG--KNYTC-------------RCPQGYQLD 337
                             C     C +G H     + C             RC  G+ L 
Sbjct: 744 HCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGF-LQ 802

Query: 338 SSQLDCVDVDECQD--SPCAQ--ECVNTPGGFRCE-----CWVGYEPGGPGEGACQDVDE 388
             + +CVD++EC     PC     C+NT G + C+     C  GY     G   C DV+E
Sbjct: 803 DPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGT-KCVDVNE 861

Query: 389 CALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNT 446
           C  G   C +G  C N  GS+ C C+ G+      G  C DV+EC    G LC   C NT
Sbjct: 862 CETGVHRCGEGQVCHNLPGSYRCDCKAGFQ-RDAFGRGCIDVNECWASPGRLCQHTCENT 920

Query: 447 QGSFHCGCLPGWVLAPNGVSC 467
            GS+ C C  G++LA +G  C
Sbjct: 921 LGSYRCSCASGFLLAADGKRC 941



 Score =  107 bits (267), Expect = 3e-23
 Identities = 75/219 (34%), Positives = 92/219 (42%), Gaps = 20/219 (9%)

Query: 225  CGEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFL 284
            CGEG         + C  KA   F   + G  C+     C  + G   Q   E   GS+ 
Sbjct: 869  CGEGQVCHNLPGSYRCDCKAG--FQRDAFGRGCIDVNE-CWASPGRLCQHTCENTLGSYR 925

Query: 285  CGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCV 344
            C C  GF L  D   C   N C +  C      + G    +Y C C QGYQL      C 
Sbjct: 926  CSCASGFLLAADGKRCEDVNECEAQRCSQECANIYG----SYQCYCRQGYQLAEDGHTCT 981

Query: 345  DVDECQDSP---CAQECVNTPGGFRCEC-WVGYEPGGPGEGACQDVDECALGRSPC--AQ 398
            D+DEC       C   C+N PG ++C C   GY     G  +C+DVDECALG   C  A+
Sbjct: 982  DIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGR-SCKDVDECALGTHNCSEAE 1040

Query: 399  GCTNTDGSFHC---SCEEGYVLAGE---DGTQCQDVDEC 431
             C N  GSF C    C   YV   +   + T C D  EC
Sbjct: 1041 TCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLEC 1079



 Score =  102 bits (253), Expect = 1e-21
 Identities = 74/234 (31%), Positives = 99/234 (42%), Gaps = 49/234 (20%)

Query: 281 GSFLCGCRPGFRLLDDLVTC----------ASRNPCSSS------------------PCR 312
           GS+ C C PGF L DD  TC          A + P   S                   C+
Sbjct: 625 GSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCK 684

Query: 313 GGATC--VLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDS--PCA--QECVNTPGGFR 366
               C  V    G +  C C  GY + +  + C D++EC      C+  + CVNT G F 
Sbjct: 685 DNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFH 744

Query: 367 CECWVGYEPG-GPGEGACQDVDECALGRSPCAQG--CTNTDGSFHCS----CEEGYVLAG 419
           C   +  EPG    +G C+DVDECA+G   C  G  C NT GSF+C     C +G++   
Sbjct: 745 CYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDP 804

Query: 420 EDGTQCQDVDECVGPGGPLCDSL-CFNTQGSFHCG-----CLPGWVLAPNGVSC 467
           E    C D++EC     P      C NT GS+ C      C  G+  + +G  C
Sbjct: 805 EG--NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKC 856



 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 51/175 (29%), Positives = 64/175 (36%), Gaps = 44/175 (25%)

Query: 345 DVDECQDSP---CAQECVNTPGGFRCECWVGY----------------EPGGPGEGACQD 385
           D DEC   P   C   C+NT G + C C+ G+                +P  P E A + 
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663

Query: 386 ---------------VDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDE 430
                                   PC Q C+   GS  CSC  GY +   DG  C+D++E
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMA-DGVSCEDINE 722

Query: 431 CVGPGGPLC-DSLCFNTQGSFHC----GCLPGWVLAPNGV----SCTMGPVSLGP 476
           CV           C NT GSFHC     C PG+ L          C MG  +  P
Sbjct: 723 CVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQP 777



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 25/58 (43%), Positives = 30/58 (51%), Gaps = 7/58 (12%)

Query: 427 DVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGPPDEE 484
           D DEC+   G LC  LC NT GS+HC C PG+ L  +G +C        P   PP  E
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCR-------PEGHPPQPE 654



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 36/129 (27%), Positives = 46/129 (35%), Gaps = 33/129 (25%)

Query: 371 VGYEPGGPGEGACQDVDECALGRSP-CAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVD 429
           +G E   P      D DEC L     C   C NT GS+HC+C  G+ L  +DG  C+   
Sbjct: 590 LGTEAELPNSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQ-DDGRTCRPEG 648

Query: 430 ECVGPGGPL-------------------------------CDSLCFNTQGSFHCGCLPGW 458
               P  P                                C  +C    GS  C C PG+
Sbjct: 649 HPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGY 708

Query: 459 VLAPNGVSC 467
            +  +GVSC
Sbjct: 709 AIMADGVSC 717


>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  127 bits (319), Expect = 3e-29
 Identities = 82/207 (39%), Positives = 107/207 (51%), Gaps = 30/207 (14%)

Query: 281  GSFLCG----CRPGFRLLDDLVTCASRNPCSS--SPCRGGATCV--LGPHGKNYTCR--- 329
            GSF C     C  GF L D    C   N C+S   PCR G +C+  +G    +YTC+   
Sbjct: 833  GSFYCQARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFSCINTVG----SYTCQRNP 887

Query: 330  --CPQGYQLDSSQLDCVDVDECQDSP--CA--QECVNTPGGFRCECWVGYEPGGPGEGAC 383
              C +GY        CVDV+EC+     C   Q C N PG +RC+C  G++    G G C
Sbjct: 888  LICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRG-C 946

Query: 384  QDVDEC--ALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS 441
             DV+EC  + GR  C   C NT GS+ CSC  G++LA  DG +C+DV+EC       C  
Sbjct: 947  IDVNECWASPGRL-CQHTCENTLGSYRCSCASGFLLAA-DGKRCEDVNECEAQR---CSQ 1001

Query: 442  LCFNTQGSFHCGCLPGWVLAPNGVSCT 468
             C N  GS+ C C  G+ LA +G +CT
Sbjct: 1002 ECANIYGSYQCYCRQGYQLAEDGHTCT 1028



 Score =  117 bits (293), Expect = 3e-26
 Identities = 70/188 (37%), Positives = 93/188 (49%), Gaps = 15/188 (7%)

Query: 281  GSFLCGCRPGFRLLDDLVTCASRNPCSSSP---CRGGATCVLGPHGKNYTCRCPQGYQLD 337
            GS+ C C+ GF+       C   N C +SP   C+      LG    +Y C C  G+ L 
Sbjct: 927  GSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLG----SYRCSCASGFLLA 982

Query: 338  SSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRS-PC 396
            +    C DV+EC+   C+QEC N  G ++C C  GY+    G   C D+DECA G    C
Sbjct: 983  ADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGH-TCTDIDECAQGAGILC 1041

Query: 397  AQGCTNTDGSFHCSC-EEGYVLAGEDGTQCQDVDEC-VGPGGPLCDSLCFNTQGSFHC-- 452
               C N  GS+ C+C E+GY +   +G  C+DVDEC +G         C N QGSF C  
Sbjct: 1042 TFRCLNVPGSYQCACPEQGYTMTA-NGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLR 1100

Query: 453  -GCLPGWV 459
              C P +V
Sbjct: 1101 FECPPNYV 1108



 Score =  116 bits (291), Expect = 6e-26
 Identities = 79/223 (35%), Positives = 111/223 (49%), Gaps = 26/223 (11%)

Query: 267 NNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPC--SSSPCRGGATCV--LGP- 321
           +NG C Q C   G GS +C C PG+ ++ D V+C  ++ C   +  C     CV  LG  
Sbjct: 685 DNGPCKQVCSTVG-GSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSF 743

Query: 322 HGKNYTCRCPQGYQLDSSQLDCVDVDECQDS--PCA--QECVNTPGGFRCECWVGYEPG- 376
           +  N+T  C  GY L++ +  CVD++EC      C+  + CVNT G F C   +  EPG 
Sbjct: 744 YCVNHTVLCADGYILNAHR-KCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY 802

Query: 377 GPGEGACQDVDECALGRSPCAQG--CTNTDGSFHCS----CEEGYVLAGEDGTQCQDVDE 430
              +G C+DVDECA+G   C  G  C NT GSF+C     C +G++   E    C D++E
Sbjct: 803 ALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEG--NCVDINE 860

Query: 431 CVGPGGPLCDSL-CFNTQGSFHCG-----CLPGWVLAPNGVSC 467
           C     P      C NT GS+ C      C  G+  + +G  C
Sbjct: 861 CTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKC 903



 Score =  107 bits (267), Expect = 3e-23
 Identities = 75/219 (34%), Positives = 92/219 (42%), Gaps = 20/219 (9%)

Query: 225  CGEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFL 284
            CGEG         + C  KA   F   + G  C+     C  + G   Q   E   GS+ 
Sbjct: 916  CGEGQVCHNLPGSYRCDCKAG--FQRDAFGRGCIDVNE-CWASPGRLCQHTCENTLGSYR 972

Query: 285  CGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCV 344
            C C  GF L  D   C   N C +  C      + G    +Y C C QGYQL      C 
Sbjct: 973  CSCASGFLLAADGKRCEDVNECEAQRCSQECANIYG----SYQCYCRQGYQLAEDGHTCT 1028

Query: 345  DVDECQDSP---CAQECVNTPGGFRCEC-WVGYEPGGPGEGACQDVDECALGRSPC--AQ 398
            D+DEC       C   C+N PG ++C C   GY     G  +C+DVDECALG   C  A+
Sbjct: 1029 DIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGR-SCKDVDECALGTHNCSEAE 1087

Query: 399  GCTNTDGSFHC---SCEEGYVLAGE---DGTQCQDVDEC 431
             C N  GSF C    C   YV   +   + T C D  EC
Sbjct: 1088 TCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLEC 1126



 Score =  106 bits (264), Expect = 8e-23
 Identities = 71/206 (34%), Positives = 94/206 (45%), Gaps = 24/206 (11%)

Query: 281 GSFLC----GCRPGFRLLDDLVTCASRNPCS--SSPCRGGATC--VLGPHGKNYTCRCPQ 332
           GSF C     C PG+ L D    C   + C+  +  C+ G  C    G        RC  
Sbjct: 788 GSFHCYKALTCEPGYALKDG--ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMD 845

Query: 333 GYQLDSSQLDCVDVDECQD--SPCAQ--ECVNTPGGFRCE-----CWVGYEPGGPGEGAC 383
           G+ L   + +CVD++EC     PC     C+NT G + C+     C  GY     G   C
Sbjct: 846 GF-LQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGT-KC 903

Query: 384 QDVDECALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS 441
            DV+EC  G   C +G  C N  GS+ C C+ G+      G  C DV+EC    G LC  
Sbjct: 904 VDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQ-RDAFGRGCIDVNECWASPGRLCQH 962

Query: 442 LCFNTQGSFHCGCLPGWVLAPNGVSC 467
            C NT GS+ C C  G++LA +G  C
Sbjct: 963 TCENTLGSYRCSCASGFLLAADGKRC 988



 Score =  102 bits (255), Expect = 8e-22
 Identities = 81/235 (34%), Positives = 101/235 (42%), Gaps = 57/235 (24%)

Query: 281 GSFLCGCRPGFRLLDDLVTC----------ASRNPCSSS------------------PCR 312
           GS+ C C PGF L DD  TC          A + P   S                   C+
Sbjct: 625 GSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCK 684

Query: 313 GGATC--VLGPHGKNYTCRCPQGYQLDSSQLDCVDVDEC----QDSPCAQECVNTPGGFR 366
               C  V    G +  C C  GY + +  + C D DEC     D    Q CVNT G F 
Sbjct: 685 DNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFY 744

Query: 367 CE-----CWVGYEPGGPGEGACQDVDECALGRSPCAQG--CTNTDGSFHC----SCEEGY 415
           C      C  GY         C D++EC      C++G  C NT GSFHC    +CE GY
Sbjct: 745 CVNHTVLCADGYILN--AHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY 802

Query: 416 VLAGEDGTQCQDVDECVGPGGPLCDS--LCFNTQGSFHC----GCLPGWVLAPNG 464
            L  +DG +C+DVDEC   G   C    LC NT+GSF+C     C+ G++  P G
Sbjct: 803 AL--KDG-ECEDVDEC-AMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEG 853



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 47/157 (29%), Positives = 60/157 (38%), Gaps = 43/157 (27%)

Query: 345 DVDECQDSP---CAQECVNTPGGFRCECWVGY----------------EPGGPGEGACQD 385
           D DEC   P   C   C+NT G + C C+ G+                +P  P E A + 
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663

Query: 386 ---------------VDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDE 430
                                   PC Q C+   GS  CSC  GY +   DG  C+D DE
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMA-DGVSCEDQDE 722

Query: 431 CVGPGGPLCD--SLCFNTQGSFHCG-----CLPGWVL 460
           C+  G   C     C NT GSF+C      C  G++L
Sbjct: 723 CL-MGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYIL 758



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 25/58 (43%), Positives = 30/58 (51%), Gaps = 7/58 (12%)

Query: 427 DVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGPPDEE 484
           D DEC+   G LC  LC NT GS+HC C PG+ L  +G +C        P   PP  E
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCR-------PEGHPPQPE 654



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 36/129 (27%), Positives = 46/129 (35%), Gaps = 33/129 (25%)

Query: 371 VGYEPGGPGEGACQDVDECALGRSP-CAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVD 429
           +G E   P      D DEC L     C   C NT GS+HC+C  G+ L  +DG  C+   
Sbjct: 590 LGTEAELPNSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQ-DDGRTCRPEG 648

Query: 430 ECVGPGGPL-------------------------------CDSLCFNTQGSFHCGCLPGW 458
               P  P                                C  +C    GS  C C PG+
Sbjct: 649 HPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGY 708

Query: 459 VLAPNGVSC 467
            +  +GVSC
Sbjct: 709 AIMADGVSC 717


>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
          Length = 988

 Score =  126 bits (316), Expect = 7e-29
 Identities = 81/241 (33%), Positives = 105/241 (43%), Gaps = 51/241 (21%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNP---------------CSS 308
           C  NNGGC Q C     GS+ C C  GF L D+  TC  R+                C  
Sbjct: 121 CQDNNGGCQQICVNAM-GSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRE 179

Query: 309 SP-------CRGG-----------ATCVLGPHGKNY---------TCRCPQGYQLDSSQL 341
           +P       CR G            TC  G  G  +         TC C Q Y L S   
Sbjct: 180 TPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGR 239

Query: 342 DCVDVDECQDSPCAQECVNTPGGFRCECWVGY--EPGGPGEGACQDVDECALGRSPCAQG 399
            C++     +  C + C +T  G RC C VG+  +P G     C+D++EC +    C   
Sbjct: 240 TCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGK---TCKDINECLVNNGGCDHF 296

Query: 400 CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWV 459
           C NT GSF C C +GY L  ++ T CQD+DEC       CD +C N+ GSF C C  G++
Sbjct: 297 CRNTVGSFECGCRKGYKLLTDERT-CQDIDEC--SFERTCDHICINSPGSFQCLCHRGYI 353

Query: 460 L 460
           L
Sbjct: 354 L 354



 Score =  116 bits (291), Expect = 6e-26
 Identities = 75/245 (30%), Positives = 104/245 (42%), Gaps = 14/245 (5%)

Query: 252 SSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPC 311
           S G  C+     C  NNGGC + C +   G   C C  GF L  D  TC   N C  +  
Sbjct: 236 SDGRTCIET---CAVNNGGCDRTCKDTATG-VRCSCPVGFTLQPDGKTCKDINECLVN-- 289

Query: 312 RGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQ-DSPCAQECVNTPGGFRCECW 370
            GG          ++ C C +GY+L + +  C D+DEC  +  C   C+N+PG F+C C 
Sbjct: 290 NGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCH 349

Query: 371 VGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDE 430
            GY   G     C DVDEC++    C QGC NT GS+ C C  G  L   +G  C +  +
Sbjct: 350 RGYILYGTTH--CGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHW-NGKDCVETGK 406

Query: 431 CVGPG--GPLCDSLCFNTQGSFHC--GCLPGWVLAPNGVSCTMGPVSLGPPSGPPDEEDK 486
           C+      P     C    G   C   C    +  P+  +  +    +  P G   ++  
Sbjct: 407 CLSRAKTSPRAQLSCSKAGGVESCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRN 466

Query: 487 GEKEG 491
           G   G
Sbjct: 467 GTSSG 471



 Score =  103 bits (256), Expect = 6e-22
 Identities = 72/247 (29%), Positives = 102/247 (41%), Gaps = 50/247 (20%)

Query: 265 NFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGK 324
           ++ NGGC  +C     G++ C C  GF L  D   C   + C  +   GG   +      
Sbjct: 81  DYYNGGCVHECINI-PGNYRCTCFDGFMLAHDGHNCLDVDECQDN--NGGCQQICVNAMG 137

Query: 325 NYTCRCPQGYQLDSSQLDCV----DVDEC--QDSPCAQECVNTP-GGFRCECWVGYEPG- 376
           +Y C+C  G+ L  +Q  C+    +   C  +D  CA  C  TP GG  C+C  G++   
Sbjct: 138 SYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQ 197

Query: 377 ---------GPGEGACQD--------------------------VDECALGRSPCAQGCT 401
                      G G CQ                           ++ CA+    C + C 
Sbjct: 198 NQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCK 257

Query: 402 NTDGSFHCSCEEGYVLAGEDGTQCQDVDEC-VGPGGPLCDSLCFNTQGSFHCGCLPGWVL 460
           +T     CSC  G+ L   DG  C+D++EC V  GG  CD  C NT GSF CGC  G+ L
Sbjct: 258 DTATGVRCSCPVGFTLQ-PDGKTCKDINECLVNNGG--CDHFCRNTVGSFECGCRKGYKL 314

Query: 461 APNGVSC 467
             +  +C
Sbjct: 315 LTDERTC 321



 Score =  102 bits (254), Expect = 1e-21
 Identities = 59/173 (34%), Positives = 78/173 (45%), Gaps = 26/173 (15%)

Query: 311 CRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDS----PCAQECVNTPGGFR 366
           C   A C   P  K+Y C C  GY+ +  Q  C D+DEC++      C  EC+N PG +R
Sbjct: 44  CHIDAICQNTP--KSYKCLCKPGYKGEGKQ--CEDIDECENDYYNGGCVHECINIPGNYR 99

Query: 367 CECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLA-------- 418
           C C+ G+     G   C DVDEC      C Q C N  GS+ C C  G+ L+        
Sbjct: 100 CTCFDGFMLAHDGHN-CLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIH 158

Query: 419 -GEDGTQCQDVDECVGPGGPLCDSLCFNT-QGSFHCGCLPGWVLAPNGVSCTM 469
              +G  C + D         C  +C  T +G   C C PG+ LA N   CT+
Sbjct: 159 RSNEGMNCMNKDHG-------CAHICRETPKGGVACDCRPGFDLAQNQKDCTL 204



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 48/141 (34%), Positives = 70/141 (49%), Gaps = 24/141 (17%)

Query: 330 CPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEG-ACQDVDE 388
           C +G   D   +D +    CQ++P +         ++C C    +PG  GEG  C+D+DE
Sbjct: 37  CSEG--TDDCHIDAI----CQNTPKS---------YKCLC----KPGYKGEGKQCEDIDE 77

Query: 389 CA--LGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNT 446
           C        C   C N  G++ C+C +G++LA  DG  C DVDEC    G  C  +C N 
Sbjct: 78  CENDYYNGGCVHECINIPGNYRCTCFDGFMLA-HDGHNCLDVDECQDNNGG-CQQICVNA 135

Query: 447 QGSFHCGCLPGWVLAPNGVSC 467
            GS+ C C  G+ L+ N  +C
Sbjct: 136 MGSYECQCHSGFFLSDNQHTC 156



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 40/97 (41%), Positives = 51/97 (52%), Gaps = 10/97 (10%)

Query: 376 GGPGEGACQDVDECALGRSPCAQG--CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVG 433
           GG G     DVDEC+ G   C     C NT  S+ C C+ GY   GE G QC+D+DEC  
Sbjct: 24  GGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGE-GKQCEDIDECEN 80

Query: 434 P---GGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
               GG  C   C N  G++ C C  G++LA +G +C
Sbjct: 81  DYYNGG--CVHECINIPGNYRCTCFDGFMLAHDGHNC 115


>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
          Length = 937

 Score =  125 bits (314), Expect = 1e-28
 Identities = 75/216 (34%), Positives = 106/216 (49%), Gaps = 11/216 (5%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHG 323
           C   + GC Q C    D SF+C C  GF + +DL TC+  + C  S      +CV     
Sbjct: 447 CAQQDHGCEQLCLNTED-SFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCV--NMD 503

Query: 324 KNYTCRCPQGYQLDSSQLDCVDVDECQ--DSPCAQECVNTPGGFRCECWVGYEPGGPGEG 381
           +++ C+CP+G+ L S    C  +D C   D  C   CV++   F C+C+ GY     G+ 
Sbjct: 504 RSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGK- 562

Query: 382 ACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS 441
            C+  D C      C   C N+D S+ C C EG+ LA EDG +C+  D C       C+ 
Sbjct: 563 TCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLA-EDGKRCRRKDVCKSTHHG-CEH 620

Query: 442 LCFNTQGSFHCGCLPGWVLAPNG---VSCTMGPVSL 474
           +C N   S+ C C  G+VLA +G     CT GP+ L
Sbjct: 621 ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDL 656



 Score =  121 bits (303), Expect = 2e-27
 Identities = 63/190 (33%), Positives = 93/190 (48%), Gaps = 7/190 (3%)

Query: 281 GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQ 340
           GS++C C+ G+ L  D  TC  ++ C+         CV  P   ++ C+C  GY L    
Sbjct: 258 GSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVP--GSFVCQCYSGYALAEDG 315

Query: 341 LDCVDVDEC--QDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQ 398
             CV VD C  ++  C  ECVN  G + C+C  G+    P +  C  +D CA     C  
Sbjct: 316 KRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFAL-NPDKKTCTKIDYCASSNHGCQH 374

Query: 399 GCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGW 458
            C NTD S+ C C +G+ L   D   C+ ++ C     P C+  C N + S++C C  G+
Sbjct: 375 ECVNTDDSYSCHCLKGFTL-NPDKKTCRRINYC-ALNKPGCEHECVNMEESYYCRCHRGY 432

Query: 459 VLAPNGVSCT 468
            L PNG +C+
Sbjct: 433 TLDPNGKTCS 442



 Score =  120 bits (302), Expect = 3e-27
 Identities = 90/297 (30%), Positives = 117/297 (39%), Gaps = 89/297 (29%)

Query: 254 GPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSS---- 309
           G  CV+  Y C   N GC  +C    DGS+LC C  GF L  D  TC   + C+SS    
Sbjct: 315 GKRCVAVDY-CASENHGCEHECVNA-DGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGC 372

Query: 310 --------------------------PCRGGATCVLGPHG---------KNYTCRCPQGY 334
                                      CR    C L   G         ++Y CRC +GY
Sbjct: 373 QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGY 432

Query: 335 QLDSSQLDCVDVDEC--QDSPCAQECVNTPGGFRCECWVGYE------------------ 374
            LD +   C  VD C  QD  C Q C+NT   F C+C  G+                   
Sbjct: 433 TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSD 492

Query: 375 ------------------PGGP---GEG-ACQDVDECALGRSPCAQGCTNTDGSFHCSCE 412
                             P G     +G  C  +D CALG   C   C +++ SF C C 
Sbjct: 493 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF 552

Query: 413 EGYVLAGEDGTQC--QDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
           EGY+L  EDG  C  +DV + +  G   C+ +C N+  S+ C CL G+ LA +G  C
Sbjct: 553 EGYILR-EDGKTCRRKDVCQAIDHG---CEHICVNSDDSYTCECLEGFRLAEDGKRC 605



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 63/192 (32%), Positives = 82/192 (42%), Gaps = 14/192 (7%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHG 323
           C  ++ GC   C    D SF C C  G  L  D  TCA  + C+        +CV     
Sbjct: 488 CLLSDHGCEYSCVNM-DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSED- 545

Query: 324 KNYTCRCPQGYQLDSSQLDCVDVDECQ--DSPCAQECVNTPGGFRCECWVGYEPGGPGEG 381
            ++ C+C +GY L      C   D CQ  D  C   CVN+   + CEC  G+     G+ 
Sbjct: 546 -SFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGK- 603

Query: 382 ACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS 441
            C+  D C      C   C N   S+ C C EG+VLA EDG +C+   E     GP+   
Sbjct: 604 RCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLA-EDGRRCKKCTE-----GPI--D 655

Query: 442 LCFNTQGSFHCG 453
           L F   GS   G
Sbjct: 656 LVFVIDGSKSLG 667



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 46/115 (40%), Positives = 57/115 (49%), Gaps = 3/115 (2%)

Query: 354 CAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEE 413
           CA  C+N PG + C C  GY      +  C+  D CA+    C Q C N  GSF C C  
Sbjct: 249 CAHFCINIPGSYVCRCKQGYILNS-DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYS 307

Query: 414 GYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCT 468
           GY LA EDG +C  VD C       C+  C N  GS+ C C  G+ L P+  +CT
Sbjct: 308 GYALA-EDGKRCVAVDYCASENHG-CEHECVNADGSYLCQCHEGFALNPDKKTCT 360



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 31/79 (39%), Positives = 40/79 (50%), Gaps = 2/79 (2%)

Query: 389 CALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQG 448
           C+     CA  C N  GS+ C C++GY+L   D T C+  D C       C+ LC N  G
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYIL-NSDQTTCRIQDLCAMEDHN-CEQLCVNVPG 299

Query: 449 SFHCGCLPGWVLAPNGVSC 467
           SF C C  G+ LA +G  C
Sbjct: 300 SFVCQCYSGYALAEDGKRC 318


>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
          Length = 956

 Score =  125 bits (314), Expect = 1e-28
 Identities = 75/216 (34%), Positives = 106/216 (49%), Gaps = 11/216 (5%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHG 323
           C   + GC Q C    D SF+C C  GF + +DL TC+  + C  S      +CV     
Sbjct: 447 CAQQDHGCEQLCLNTED-SFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCV--NMD 503

Query: 324 KNYTCRCPQGYQLDSSQLDCVDVDECQ--DSPCAQECVNTPGGFRCECWVGYEPGGPGEG 381
           +++ C+CP+G+ L S    C  +D C   D  C   CV++   F C+C+ GY     G+ 
Sbjct: 504 RSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGK- 562

Query: 382 ACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS 441
            C+  D C      C   C N+D S+ C C EG+ LA EDG +C+  D C       C+ 
Sbjct: 563 TCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLA-EDGKRCRRKDVCKSTHHG-CEH 620

Query: 442 LCFNTQGSFHCGCLPGWVLAPNG---VSCTMGPVSL 474
           +C N   S+ C C  G+VLA +G     CT GP+ L
Sbjct: 621 ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDL 656



 Score =  121 bits (303), Expect = 2e-27
 Identities = 63/190 (33%), Positives = 93/190 (48%), Gaps = 7/190 (3%)

Query: 281 GSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQ 340
           GS++C C+ G+ L  D  TC  ++ C+         CV  P   ++ C+C  GY L    
Sbjct: 258 GSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVP--GSFVCQCYSGYALAEDG 315

Query: 341 LDCVDVDEC--QDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQ 398
             CV VD C  ++  C  ECVN  G + C+C  G+    P +  C  +D CA     C  
Sbjct: 316 KRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFAL-NPDKKTCTKIDYCASSNHGCQH 374

Query: 399 GCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGW 458
            C NTD S+ C C +G+ L   D   C+ ++ C     P C+  C N + S++C C  G+
Sbjct: 375 ECVNTDDSYSCHCLKGFTL-NPDKKTCRRINYC-ALNKPGCEHECVNMEESYYCRCHRGY 432

Query: 459 VLAPNGVSCT 468
            L PNG +C+
Sbjct: 433 TLDPNGKTCS 442



 Score =  120 bits (302), Expect = 3e-27
 Identities = 90/297 (30%), Positives = 117/297 (39%), Gaps = 89/297 (29%)

Query: 254 GPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSS---- 309
           G  CV+  Y C   N GC  +C    DGS+LC C  GF L  D  TC   + C+SS    
Sbjct: 315 GKRCVAVDY-CASENHGCEHECVNA-DGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGC 372

Query: 310 --------------------------PCRGGATCVLGPHG---------KNYTCRCPQGY 334
                                      CR    C L   G         ++Y CRC +GY
Sbjct: 373 QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGY 432

Query: 335 QLDSSQLDCVDVDEC--QDSPCAQECVNTPGGFRCECWVGYE------------------ 374
            LD +   C  VD C  QD  C Q C+NT   F C+C  G+                   
Sbjct: 433 TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSD 492

Query: 375 ------------------PGGP---GEG-ACQDVDECALGRSPCAQGCTNTDGSFHCSCE 412
                             P G     +G  C  +D CALG   C   C +++ SF C C 
Sbjct: 493 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF 552

Query: 413 EGYVLAGEDGTQC--QDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
           EGY+L  EDG  C  +DV + +  G   C+ +C N+  S+ C CL G+ LA +G  C
Sbjct: 553 EGYILR-EDGKTCRRKDVCQAIDHG---CEHICVNSDDSYTCECLEGFRLAEDGKRC 605



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 63/192 (32%), Positives = 82/192 (42%), Gaps = 14/192 (7%)

Query: 264 CNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHG 323
           C  ++ GC   C    D SF C C  G  L  D  TCA  + C+        +CV     
Sbjct: 488 CLLSDHGCEYSCVNM-DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSED- 545

Query: 324 KNYTCRCPQGYQLDSSQLDCVDVDECQ--DSPCAQECVNTPGGFRCECWVGYEPGGPGEG 381
            ++ C+C +GY L      C   D CQ  D  C   CVN+   + CEC  G+     G+ 
Sbjct: 546 -SFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGK- 603

Query: 382 ACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDS 441
            C+  D C      C   C N   S+ C C EG+VLA EDG +C+   E     GP+   
Sbjct: 604 RCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLA-EDGRRCKKCTE-----GPI--D 655

Query: 442 LCFNTQGSFHCG 453
           L F   GS   G
Sbjct: 656 LVFVIDGSKSLG 667



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 46/115 (40%), Positives = 57/115 (49%), Gaps = 3/115 (2%)

Query: 354 CAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEE 413
           CA  C+N PG + C C  GY      +  C+  D CA+    C Q C N  GSF C C  
Sbjct: 249 CAHFCINIPGSYVCRCKQGYILNS-DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYS 307

Query: 414 GYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCT 468
           GY LA EDG +C  VD C       C+  C N  GS+ C C  G+ L P+  +CT
Sbjct: 308 GYALA-EDGKRCVAVDYCASENHG-CEHECVNADGSYLCQCHEGFALNPDKKTCT 360



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 31/79 (39%), Positives = 40/79 (50%), Gaps = 2/79 (2%)

Query: 389 CALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQG 448
           C+     CA  C N  GS+ C C++GY+L   D T C+  D C       C+ LC N  G
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYIL-NSDQTTCRIQDLCAMEDHN-CEQLCVNVPG 299

Query: 449 SFHCGCLPGWVLAPNGVSC 467
           SF C C  G+ LA +G  C
Sbjct: 300 SFVCQCYSGYALAEDGKRC 318


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  124 bits (311), Expect = 3e-28
 Identities = 83/216 (38%), Positives = 104/216 (48%), Gaps = 24/216 (11%)

Query: 264  CNFNNGGCH--QDCFEGGDGSFLC--GCRPGFRLLDDLVTCASRNPCS-SSPCRGGATCV 318
            C      CH  QDC +   GS+ C   C  GFR   D ++C   N C  SSPC       
Sbjct: 5151 CALGRHTCHAGQDC-DNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQRCFNA 5209

Query: 319  LGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCA--QECVNTPGGFRCECWVGYEPG 376
            +G    ++ C C  GYQL   +  C+DV+EC+ + C   Q C NT GG++C   +   P 
Sbjct: 5210 IG----SFHCGCEPGYQLKGRK--CMDVNECRQNVCRPDQHCKNTRGGYKC---IDLCPN 5260

Query: 377  GPGE---GACQDVDECALGRSPCA--QGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDEC 431
            G  +   G C D+DEC  G   C   Q C NT GS+ C C  GY   G  G  C D++EC
Sbjct: 5261 GMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGV-GRPCMDINEC 5319

Query: 432  VGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
                 P C   C NT GSF C C PG  L  +G SC
Sbjct: 5320 EQVPKP-CAHQCSNTPGSFKCICPPGQHLLGDGKSC 5354



 Score =  114 bits (285), Expect = 3e-25
 Identities = 61/137 (44%), Positives = 72/137 (52%), Gaps = 9/137 (6%)

Query: 329  RCPQGYQLDSSQLDCVDVDEC-QDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVD 387
            +CP G+ LDS    C D DEC   +PC+  C N  G + C C  G      G   CQD+D
Sbjct: 5091 QCPSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGR-TCQDID 5149

Query: 388  ECALGRSPC--AQGCTNTDGSFHC--SCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLC 443
            ECALGR  C   Q C NT GS+ C   C  G+     DG  CQD++EC       C   C
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGF-RRTSDGLSCQDINEC--QESSPCHQRC 5206

Query: 444  FNTQGSFHCGCLPGWVL 460
            FN  GSFHCGC PG+ L
Sbjct: 5207 FNAIGSFHCGCEPGYQL 5223



 Score =  108 bits (271), Expect = 1e-23
 Identities = 64/163 (39%), Positives = 77/163 (47%), Gaps = 10/163 (6%)

Query: 271  CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRC 330
            CHQ CF    GSF CGC PG++L      C   N C  + CR    C     G      C
Sbjct: 5202 CHQRCFNA-IGSFHCGCEPGYQLKGR--KCMDVNECRQNVCRPDQHCKNTRGGYKCIDLC 5258

Query: 331  PQGYQLDSSQLDCVDVDECQDSP--CA--QECVNTPGGFRCECWVGYEPGGPGEGACQDV 386
            P G    +    C+D+DEC+D    C   Q C NT G +RC C  GY   G G   C D+
Sbjct: 5259 PNG-MTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGR-PCMDI 5316

Query: 387  DECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVD 429
            +EC     PCA  C+NT GSF C C  G  L G DG  C  ++
Sbjct: 5317 NECEQVPKPCAHQCSNTPGSFKCICPPGQHLLG-DGKSCAGLE 5358



 Score =  104 bits (259), Expect = 3e-22
 Identities = 69/189 (36%), Positives = 89/189 (47%), Gaps = 23/189 (12%)

Query: 287  CRPGFRLLDDLVTCASRNPCSS-SPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVD 345
            C  GF L      CA  + C++ +PC       +G     Y C CP+G  + +    C D
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMG----TYYCSCPKGLTIAADGRTCQD 5147

Query: 346  VDEC----QDSPCAQECVNTPGGFRC--ECWVGYEPGGPGEGACQDVDECALGRSPCAQG 399
            +DEC          Q+C NT G +RC   C  G+     G  +CQD++EC    SPC Q 
Sbjct: 5148 IDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGL-SCQDINECQES-SPCHQR 5205

Query: 400  CTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLC--DSLCFNTQGSFHC--GCL 455
            C N  GSFHC CE GY L G    +C DV+EC      +C  D  C NT+G + C   C 
Sbjct: 5206 CFNAIGSFHCGCEPGYQLKGR---KCMDVNEC---RQNVCRPDQHCKNTRGGYKCIDLCP 5259

Query: 456  PGWVLAPNG 464
             G   A NG
Sbjct: 5260 NGMTKAENG 5268



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 68/223 (30%), Positives = 87/223 (39%), Gaps = 33/223 (14%)

Query: 271  CHQDCFEGGDGSFLCGCRPGFRLLDDLVTCAS--RNPCSSSPCRGGATCVLGPHGKNYTC 328
            C   C     GSF C C PG  LL D  +CA   R P   +           P   NY  
Sbjct: 5326 CAHQC-SNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQ- 5383

Query: 329  RCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDE 388
              PQ +    S L      E ++S  +     T    R  C  G E        C D+DE
Sbjct: 5384 --PQQHYRQYSHLYS-SYSEYRNSRTSLS--RTRRTIRKTCPEGSEAS---HDTCVDIDE 5435

Query: 389  CALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPG---GPLCDSLCFN 445
            C      C   C NT GS+ C C  GY L   +G  CQD+DEC+      GP  + +CFN
Sbjct: 5436 CE-NTDACQHECKNTFGSYQCICPPGYQLT-HNGKTCQDIDECLEQNVHCGP--NRMCFN 5491

Query: 446  TQGSFHC---GCLPGWV-----------LAPNGVSCTMGPVSL 474
             +GS+ C    C P +              PN + C + P +L
Sbjct: 5492 MRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYAL 5534



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 21/57 (36%), Positives = 28/57 (49%), Gaps = 3/57 (5%)

Query: 411  CEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSC 467
            C  G+ L    G  C D DEC   G P C   C N  G+++C C  G  +A +G +C
Sbjct: 5092 CPSGFTLDSV-GPFCADEDECAA-GNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTC 5145


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.135    0.436 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,725,603
Number of Sequences: 37866
Number of extensions: 2030930
Number of successful extensions: 17332
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 211
Number of HSP's successfully gapped in prelim test: 606
Number of HSP's that attempted gapping in prelim test: 9654
Number of HSP's gapped (non-prelim): 4822
length of query: 652
length of database: 18,247,518
effective HSP length: 109
effective length of query: 543
effective length of database: 14,120,124
effective search space: 7667227332
effective search space used: 7667227332
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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