Guide to the Human Genome
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Search of human proteins with 8659574

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8659574 transcription factor E3 [Homo sapiens]
         (575 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|8659574 transcription factor E3 [Homo sapiens]                    1115   0.0  
gi|38156699 microphthalmia-associated transcription factor isofo...   448   e-126
gi|38156703 microphthalmia-associated transcription factor isofo...   434   e-121
gi|38156701 microphthalmia-associated transcription factor isofo...   433   e-121
gi|38156705 microphthalmia-associated transcription factor isofo...   432   e-121
gi|38156697 microphthalmia-associated transcription factor isofo...   371   e-103
gi|4557755 microphthalmia-associated transcription factor isofor...   365   e-101
gi|24307933 transcription factor EB [Homo sapiens]                    345   8e-95
gi|6912702 transcription factor EC isoform a [Homo sapiens]           257   2e-68
gi|64762402 transcription factor EC isoform b [Homo sapiens]          234   2e-61
gi|52630419 sterol regulatory element binding transcription fact...    61   3e-09
gi|22547195 sterol regulatory element binding transcription fact...    61   3e-09
gi|4507847 upstream stimulatory factor 2 isoform 1 [Homo sapiens]      57   5e-08
gi|27477113 sterol regulatory element-binding transcription fact...    56   1e-07
gi|46877105 upstream stimulatory factor 2 isoform 2 [Homo sapiens]     56   1e-07
gi|19923312 v-myc myelocytomatosis viral related oncogene, neuro...    53   9e-07
gi|6005934 upstream stimulatory factor 1 isoform 1 [Homo sapiens]      53   9e-07
gi|46877102 upstream stimulatory factor 1 isoform 2 [Homo sapiens]     53   9e-07
gi|14602433 Williams Beuren syndrome chromosome region 14 isofor...    50   4e-06
gi|91208420 bassoon protein [Homo sapiens]                             50   7e-06
gi|114431248 hypothetical protein LOC205717 [Homo sapiens]             49   2e-05
gi|47717116 MAX interactor 1 isoform b [Homo sapiens]                  48   3e-05
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    47   5e-05
gi|9945318 MAX binding protein [Homo sapiens]                          47   5e-05
gi|4758010 clock [Homo sapiens]                                        46   1e-04
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo...    45   1e-04
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor...    45   1e-04
gi|5453734 MAD4 [Homo sapiens]                                         44   3e-04
gi|146134388 YLP motif containing 1 [Homo sapiens]                     44   5e-04
gi|56549694 enabled homolog isoform a [Homo sapiens]                   43   7e-04

>gi|8659574 transcription factor E3 [Homo sapiens]
          Length = 575

 Score = 1115 bits (2885), Expect = 0.0
 Identities = 575/575 (100%), Positives = 575/575 (100%)

Query: 1   MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLD 60
           MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLD
Sbjct: 1   MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLD 60

Query: 61  PDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQL 120
           PDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQL
Sbjct: 61  PDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQL 120

Query: 121 MRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ 180
           MRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ
Sbjct: 121 MRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ 180

Query: 181 THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPT 240
           THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPT
Sbjct: 181 THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPT 240

Query: 241 GSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSG 300
           GSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSG
Sbjct: 241 GSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSG 300

Query: 301 NLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRF 360
           NLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRF
Sbjct: 301 NLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRF 360

Query: 361 NINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQAN 420
           NINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQAN
Sbjct: 361 NINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQAN 420

Query: 421 RSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVG 480
           RSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVG
Sbjct: 421 RSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVG 480

Query: 481 GGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGA 540
           GGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGA
Sbjct: 481 GGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGA 540

Query: 541 LSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEES 575
           LSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEES
Sbjct: 541 LSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEES 575


>gi|38156699 microphthalmia-associated transcription factor isoform
           1 [Homo sapiens]
          Length = 520

 Score =  448 bits (1153), Expect = e-126
 Identities = 285/582 (48%), Positives = 347/582 (59%), Gaps = 124/582 (21%)

Query: 46  ESGIVADIELENVL--DPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGGSRT 103
           ESGIV D E+      +P ++YELKSQPL   SS                 +   G S+ 
Sbjct: 4   ESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSS-----------------AEHPGASKP 46

Query: 104 PAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPS---PAPASPAISVVGVSAG 160
           P  SSS +SR+LLRQQLMR Q QEQERRE++++  AA F     P   +PAI+V      
Sbjct: 47  PISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINV------ 100

Query: 161 GHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPP- 219
               + P   QVP EVLKVQTHLENPT+YH+QQA+RQQVKQYLSTTL  K A+Q L+ P 
Sbjct: 101 SVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPC 160

Query: 220 ---PGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKE---------------- 260
              PG     P+P            SAPNSPMA+LT+ S+ EKE                
Sbjct: 161 PNQPGDHVMPPVPG----------SSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECP 210

Query: 261 ------------IDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSS 308
                       +DDVID+IISLESSYN+E+L  +      LQ+ +TLPVSGNL+D+Y +
Sbjct: 211 GMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMD---PALQMANTLPVSGNLIDLYGN 267

Query: 309 QGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKE 368
           QG+  P +T+SNSCPA LPNIKRE++E+EA+AL KERQKKDNHNLIERRRRFNINDRIKE
Sbjct: 268 QGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKE 327

Query: 369 LGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQ 428
           LGTLIPKS+DP+MRWNKGTILKASVDYIRKLQ+EQQR+K+LE+RQ+ LE ANR L LRIQ
Sbjct: 328 LGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQ 387

Query: 429 ELELQAQIHGLPVPPTPGLLS-----------LATTSASDSLKPEQLDI----EEEGRPG 473
           ELE+QA+ HGL + P+ GL S               + S  L     D+      +   G
Sbjct: 388 ELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDG 447

Query: 474 AATF--HVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEG 531
             TF  ++G G   N  +  P    S                       LEDILM++   
Sbjct: 448 TITFNNNLGTGTEANQAYSVPTKMGSK----------------------LEDILMDD--- 482

Query: 532 VVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSMEE 573
                    LSP+   +DPLLSSVSP  SK SSRRSS SMEE
Sbjct: 483 --------TLSPV-GVTDPLLSSVSPGASKTSSRRSSMSMEE 515


>gi|38156703 microphthalmia-associated transcription factor isoform
           2 [Homo sapiens]
          Length = 504

 Score =  434 bits (1116), Expect = e-121
 Identities = 269/534 (50%), Positives = 328/534 (61%), Gaps = 105/534 (19%)

Query: 92  LSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPS---PAPA 148
           LS++   G S+ P  SSS +SR+LLRQQLMR Q QEQERRE++++  AA F     P   
Sbjct: 19  LSSAEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQ 78

Query: 149 SPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLG 208
           +PAI+V          + P   QVP EVLKVQTHLENPT+YH+QQA+RQQVKQYLSTTL 
Sbjct: 79  TPAINV------SVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTLA 132

Query: 209 PKLASQALTPP----PGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKE---- 260
            K A+Q L+ P    PG     P+P            SAPNSPMA+LT+ S+ EKE    
Sbjct: 133 NKHANQVLSLPCPNQPGDHVMPPVPG----------SSAPNSPMAMLTLNSNCEKEGFYK 182

Query: 261 ------------------------IDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTL 296
                                   +DDVID+IISLESSYN+E+L  +      LQ+ +TL
Sbjct: 183 FEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMD---PALQMANTL 239

Query: 297 PVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIER 356
           PVSGNL+D+Y +QG+  P +T+SNSCPA LPNIKRE++E+EA+AL KERQKKDNHNLIER
Sbjct: 240 PVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIER 299

Query: 357 RRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSL 416
           RRRFNINDRIKELGTLIPKS+DP+MRWNKGTILKASVDYIRKLQ+EQQR+K+LE+RQ+ L
Sbjct: 300 RRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKL 359

Query: 417 EQANRSLQLRIQELELQAQIHGLPVPPTPGLLS-----------LATTSASDSLKPEQLD 465
           E ANR L LRIQELE+QA+ HGL + P+ GL S               + S  L     D
Sbjct: 360 EHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHAD 419

Query: 466 I----EEEGRPGAATF--HVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHL 519
           +      +   G  TF  ++G G   N  +  P    S                      
Sbjct: 420 LTCTTTLDLTDGTITFNNNLGTGTEANQAYSVPTKMGSK--------------------- 458

Query: 520 GLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSMEE 573
            LEDILM++            LSP+   +DPLLSSVSP  SK SSRRSS SMEE
Sbjct: 459 -LEDILMDD-----------TLSPV-GVTDPLLSSVSPGASKTSSRRSSMSMEE 499


>gi|38156701 microphthalmia-associated transcription factor isoform
           3 [Homo sapiens]
          Length = 519

 Score =  433 bits (1114), Expect = e-121
 Identities = 273/541 (50%), Positives = 330/541 (60%), Gaps = 108/541 (19%)

Query: 88  TPATLSASSSA---GGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPS 144
           T    S SSSA   G S+ P  SSS +SR+LLRQQLMR Q QEQERRE++++  AA F  
Sbjct: 27  TLCLFSRSSSAEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQ 86

Query: 145 ---PAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQ 201
              P   +PAI+V          + P   QVP EVLKVQTHLENPT+YH+QQA+RQQVKQ
Sbjct: 87  QRVPVSQTPAINV------SVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQ 140

Query: 202 YLSTTLGPKLASQALTPP----PGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSS 257
           YLSTTL  K A+Q L+ P    PG     P+P            SAPNSPMA+LT+ S+ 
Sbjct: 141 YLSTTLANKHANQVLSLPCPNQPGDHVMPPVPG----------SSAPNSPMAMLTLNSNC 190

Query: 258 EKE----------------------------IDDVIDEIISLESSYNDEMLSYLPGGTTG 289
           EKE                            +DDVID+IISLESSYN+E+L  +      
Sbjct: 191 EKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMD---PA 247

Query: 290 LQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKD 349
           LQ+ +TLPVSGNL+D+Y +QG+  P +T+SNSCPA LPNIKRE++E+EA+AL KERQKKD
Sbjct: 248 LQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKD 307

Query: 350 NHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDL 409
           NHNLIERRRRFNINDRIKELGTLIPKS+DP+MRWNKGTILKASVDYIRKLQ+EQQR+K+L
Sbjct: 308 NHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKEL 367

Query: 410 ESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLS-----------LATTSASDS 458
           E+RQ+ LE ANR L LRIQELE+QA+ HGL + P+ GL S               + S  
Sbjct: 368 ENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQD 427

Query: 459 LKPEQLDI----EEEGRPGAATF--HVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGD 512
           L     D+      +   G  TF  ++G G   N  +  P    S               
Sbjct: 428 LLQHHADLTCTTTLDLTDGTITFNNNLGTGTEANQAYSVPTKMGSK-------------- 473

Query: 513 LGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSME 572
                   LEDILM++            LSP+   +DPLLSSVSP  SK SSRRSS SME
Sbjct: 474 --------LEDILMDD-----------TLSPV-GVTDPLLSSVSPGASKTSSRRSSMSME 513

Query: 573 E 573
           E
Sbjct: 514 E 514


>gi|38156705 microphthalmia-associated transcription factor isoform
           6 [Homo sapiens]
          Length = 495

 Score =  432 bits (1112), Expect = e-121
 Identities = 268/533 (50%), Positives = 327/533 (61%), Gaps = 105/533 (19%)

Query: 93  SASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPS---PAPAS 149
           S++   G S+ P  SSS +SR+LLRQQLMR Q QEQERRE++++  AA F     P   +
Sbjct: 11  SSAEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQT 70

Query: 150 PAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGP 209
           PAI+V          + P   QVP EVLKVQTHLENPT+YH+QQA+RQQVKQYLSTTL  
Sbjct: 71  PAINV------SVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTLAN 124

Query: 210 KLASQALTPP----PGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKE----- 260
           K A+Q L+ P    PG     P+P            SAPNSPMA+LT+ S+ EKE     
Sbjct: 125 KHANQVLSLPCPNQPGDHVMPPVPG----------SSAPNSPMAMLTLNSNCEKEGFYKF 174

Query: 261 -----------------------IDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLP 297
                                  +DDVID+IISLESSYN+E+L  +      LQ+ +TLP
Sbjct: 175 EEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMD---PALQMANTLP 231

Query: 298 VSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERR 357
           VSGNL+D+Y +QG+  P +T+SNSCPA LPNIKRE++E+EA+AL KERQKKDNHNLIERR
Sbjct: 232 VSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERR 291

Query: 358 RRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLE 417
           RRFNINDRIKELGTLIPKS+DP+MRWNKGTILKASVDYIRKLQ+EQQR+K+LE+RQ+ LE
Sbjct: 292 RRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLE 351

Query: 418 QANRSLQLRIQELELQAQIHGLPVPPTPGLLS-----------LATTSASDSLKPEQLDI 466
            ANR L LRIQELE+QA+ HGL + P+ GL S               + S  L     D+
Sbjct: 352 HANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADL 411

Query: 467 ----EEEGRPGAATF--HVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLG 520
                 +   G  TF  ++G G   N  +  P    S                       
Sbjct: 412 TCTTTLDLTDGTITFNNNLGTGTEANQAYSVPTKMGSK---------------------- 449

Query: 521 LEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSMEE 573
           LEDILM++            LSP+   +DPLLSSVSP  SK SSRRSS SMEE
Sbjct: 450 LEDILMDD-----------TLSPV-GVTDPLLSSVSPGASKTSSRRSSMSMEE 490


>gi|38156697 microphthalmia-associated transcription factor isoform
           5 [Homo sapiens]
          Length = 413

 Score =  371 bits (953), Expect = e-103
 Identities = 227/445 (51%), Positives = 275/445 (61%), Gaps = 96/445 (21%)

Query: 178 KVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPP----PGPASAQPLPAPEA 233
           +VQTHLENPT+YH+QQA+RQQVKQYLSTTL  K A+Q L+ P    PG     P+P    
Sbjct: 11  QVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPG--- 67

Query: 234 AHTTGPTGSAPNSPMALLTIGSSSEKE----------------------------IDDVI 265
                   SAPNSPMA+LT+ S+ EKE                            +DDVI
Sbjct: 68  -------SSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVI 120

Query: 266 DEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAE 325
           D+IISLESSYN+E+L  +      LQ+ +TLPVSGNL+D+Y +QG+  P +T+SNSCPA 
Sbjct: 121 DDIISLESSYNEEILGLMD---PALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPAN 177

Query: 326 LPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNK 385
           LPNIKRE++E+EA+AL KERQKKDNHNLIERRRRFNINDRIKELGTLIPKS+DP+MRWNK
Sbjct: 178 LPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNK 237

Query: 386 GTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTP 445
           GTILKASVDYIRKLQ+EQQR+K+LE+RQ+ LE ANR L LRIQELE+QA+ HGL + P+ 
Sbjct: 238 GTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPST 297

Query: 446 GLLS-----------LATTSASDSLKPEQLDI----EEEGRPGAATF--HVGGGPAQNAP 488
           GL S               + S  L     D+      +   G  TF  ++G G   N  
Sbjct: 298 GLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDGTITFNNNLGTGTEANQA 357

Query: 489 HQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAAS 548
           +  P    S                       LEDILM++            LSP+   +
Sbjct: 358 YSVPTKMGSK----------------------LEDILMDD-----------TLSPV-GVT 383

Query: 549 DPLLSSVSPAVSKASSRRSSFSMEE 573
           DPLLSSVSP  SK SSRRSS SMEE
Sbjct: 384 DPLLSSVSPGASKTSSRRSSMSMEE 408


>gi|4557755 microphthalmia-associated transcription factor isoform 4
           [Homo sapiens]
          Length = 419

 Score =  365 bits (936), Expect = e-101
 Identities = 227/451 (50%), Positives = 275/451 (60%), Gaps = 102/451 (22%)

Query: 178 KVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPP----PGPASAQPLPAPEA 233
           +VQTHLENPT+YH+QQA+RQQVKQYLSTTL  K A+Q L+ P    PG     P+P    
Sbjct: 11  QVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPG--- 67

Query: 234 AHTTGPTGSAPNSPMALLTIGSSSEKE----------------------------IDDVI 265
                   SAPNSPMA+LT+ S+ EKE                            +DDVI
Sbjct: 68  -------SSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVI 120

Query: 266 DEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAE 325
           D+IISLESSYN+E+L  +      LQ+ +TLPVSGNL+D+Y +QG+  P +T+SNSCPA 
Sbjct: 121 DDIISLESSYNEEILGLMD---PALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPAN 177

Query: 326 LPNIKREIS------ETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDP 379
           LPNIKRE++      E+EA+AL KERQKKDNHNLIERRRRFNINDRIKELGTLIPKS+DP
Sbjct: 178 LPNIKRELTACIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDP 237

Query: 380 EMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGL 439
           +MRWNKGTILKASVDYIRKLQ+EQQR+K+LE+RQ+ LE ANR L LRIQELE+QA+ HGL
Sbjct: 238 DMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGL 297

Query: 440 PVPPTPGLLS-----------LATTSASDSLKPEQLDI----EEEGRPGAATF--HVGGG 482
            + P+ GL S               + S  L     D+      +   G  TF  ++G G
Sbjct: 298 SLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDGTITFNNNLGTG 357

Query: 483 PAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALS 542
              N  +  P    S                       LEDILM++            LS
Sbjct: 358 TEANQAYSVPTKMGSK----------------------LEDILMDD-----------TLS 384

Query: 543 PLRAASDPLLSSVSPAVSKASSRRSSFSMEE 573
           P+   +DPLLSSVSP  SK SSRRSS SMEE
Sbjct: 385 PV-GVTDPLLSSVSPGASKTSSRRSSMSMEE 414


>gi|24307933 transcription factor EB [Homo sapiens]
          Length = 476

 Score =  345 bits (884), Expect = 8e-95
 Identities = 226/499 (45%), Positives = 294/499 (58%), Gaps = 64/499 (12%)

Query: 111 SSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSP----------APASPAISVVGVSAG 160
           +SR+ LR QLMR QAQ++E+RER +Q A   +              P +PAI+       
Sbjct: 2   ASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPV---- 57

Query: 161 GHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQAL---- 216
            H  S PP   VP EVLKVQ++LENPT YHLQQ++ Q+V++YLS T G K A+       
Sbjct: 58  -HFQSPPP---VPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQG 113

Query: 217 TPPPGPASAQPLPAPEAAHTTGPTG--SAPNSPMALLTIGSSSEKEIDDVIDEIISLESS 274
           +P P PA++   P   A H    +   SAPNSPMA+L IGS+ E+E+DDVID I+ L   
Sbjct: 114 SPKPPPAAS---PGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRL--- 167

Query: 275 YNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAIT--VSNSCPAELPNIKRE 332
             D++L Y+      +Q+P+TLP+S + L+VYSS    T ++    S+SCPA+L   KRE
Sbjct: 168 --DDVLGYI---NPEMQMPNTLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQ-KRE 221

Query: 333 ISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKAS 392
           +++ E++AL KERQKKDNHNLIERRRRFNINDRIKELG LIPK++D ++RWNKGTILKAS
Sbjct: 222 LTDAESRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKAS 281

Query: 393 VDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLAT 452
           VDYIR++QK+ Q+S++LE+  R LE  N+ L LRIQELE+QA++HGLP     G+     
Sbjct: 282 VDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTTSPSGM----- 336

Query: 453 TSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGD 512
             A  + +  + ++  E  PG A       P        PP  P         P  HL  
Sbjct: 337 NMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDF 396

Query: 513 LGDPFHLGLEDILMEEEEGVVGGLSGGALSP------------------LRAASDPLLSS 554
                  G ED   E   G    L+ G  SP                  L  ASDPLLS+
Sbjct: 397 SHSLSFGGRED---EGPPGYPEPLAPGHGSPFPSLSKKDLDLMLLDDSLLPLASDPLLST 453

Query: 555 VSPAVSKASSRRSSFSMEE 573
           +SP  SKASSRRSSFSMEE
Sbjct: 454 MSPEASKASSRRSSFSMEE 472


>gi|6912702 transcription factor EC isoform a [Homo sapiens]
          Length = 347

 Score =  257 bits (657), Expect = 2e-68
 Identities = 166/360 (46%), Positives = 213/360 (59%), Gaps = 41/360 (11%)

Query: 222 PASAQPLPAPEAAHTT--GPTGSAPNSPMALLTIGSSSEK---EIDDVIDEIISLESSYN 276
           PA     P  + AHTT     G   N    LL IG   +     ++DVI++II +ESS+ 
Sbjct: 17  PAVPSGGPLVQHAHTTLDSDAGLTENPLTKLLAIGKEDDNAQWHMEDVIEDIIGMESSFK 76

Query: 277 DEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAIT--VSNSCPAELPNIKREIS 334
           +E      G  + L +  TL  SG++LDVYS +   +P      S SCP+ LP +KREI+
Sbjct: 77  EE------GADSPLLMQRTL--SGSILDVYSGEQGISPINMGLTSASCPSSLP-MKREIT 127

Query: 335 ETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVD 394
           ET+ +AL KERQKKDNHNLIERRRR+NIN RIKELGTLIPKS+DP+MRWNKGTILKASV+
Sbjct: 128 ETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVE 187

Query: 395 YIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTS 454
           YI+ LQKEQQR+++LE RQ+ LEQANR L LRIQELE+QA+ HGLP   + G + L    
Sbjct: 188 YIKWLQKEQQRARELEHRQKKLEQANRRLLLRIQELEIQARTHGLPTLASLGTVDLGAHV 247

Query: 455 ASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPAPP-SDALLDLHFPSDHLGDL 513
                 PEQ  ++                 Q     Q P+P   D  +    P  +  DL
Sbjct: 248 TKQQSHPEQNSVDY---------------CQQLTVSQGPSPELCDQAIAFSDPLSYFTDL 292

Query: 514 GDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSMEE 573
                       ++EE+ + G L    +SP    +DPLLS+ SPAVSK SSRRSSFS ++
Sbjct: 293 S-------FSAALKEEQRLDGMLLDDTISPF--GTDPLLSATSPAVSKESSRRSSFSSDD 343


>gi|64762402 transcription factor EC isoform b [Homo sapiens]
          Length = 318

 Score =  234 bits (596), Expect = 2e-61
 Identities = 140/279 (50%), Positives = 177/279 (63%), Gaps = 28/279 (10%)

Query: 298 VSGNLLDVYSSQGVATPAIT--VSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIE 355
           +SG++LDVYS +   +P      S SCP+ LP +KREI+ET+ +AL KERQKKDNHNLIE
Sbjct: 61  LSGSILDVYSGEQGISPINMGLTSASCPSSLP-MKREITETDTRALAKERQKKDNHNLIE 119

Query: 356 RRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRS 415
           RRRR+NIN RIKELGTLIPKS+DP+MRWNKGTILKASV+YI+ LQKEQQR+++LE RQ+ 
Sbjct: 120 RRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKK 179

Query: 416 LEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAA 475
           LEQANR L LRIQELE+QA+ HGLP   + G + L          PEQ  ++        
Sbjct: 180 LEQANRRLLLRIQELEIQARTHGLPTLASLGTVDLGAHVTKQQSHPEQNSVDY------- 232

Query: 476 TFHVGGGPAQNAPHQQPPAPP-SDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVG 534
                    Q     Q P+P   D  +    P  +  DL            ++EE+ + G
Sbjct: 233 --------CQQLTVSQGPSPELCDQAIAFSDPLSYFTDLS-------FSAALKEEQRLDG 277

Query: 535 GLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSMEE 573
            L    +SP    +DPLLS+ SPAVSK SSRRSSFS ++
Sbjct: 278 MLLDDTISPF--GTDPLLSATSPAVSKESSRRSSFSSDD 314


>gi|52630419 sterol regulatory element binding transcription factor
           1 isoform a [Homo sapiens]
          Length = 1177

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 94/372 (25%), Positives = 140/372 (37%), Gaps = 45/372 (12%)

Query: 60  DPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGG--SRTPAMSSSSSSRVLLR 117
           D  S   L   P  L SSL   L    A P+ LS    A       P+M + S    +  
Sbjct: 95  DTSSPGSLSPPPATLSSSLEAFLSGPQAAPSPLSPPQPAPTPLKMYPSMPAFSPGPGIKE 154

Query: 118 QQLMRAQAQEQERRERREQAAAAPFPSPAP----ASPAISVVGVSAGGHTLSRPPPAQVP 173
           + +  +  Q    +          FP+PAP    ++P +       G  T S P   Q P
Sbjct: 155 ESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGYPSPPGGFSTGSPPGNTQQP 214

Query: 174 REVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEA 233
              L + +    P      Q +    +Q L+ T  P  A    T     +  Q +P    
Sbjct: 215 LPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVT---SQIQQVPVLLQ 271

Query: 234 AHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLP 293
            H          +   LLT   +    +                  LS L  GTT    P
Sbjct: 272 PHFI-------KADSLLLTAMKTDGATVKAA--------------GLSPLVSGTTVQTGP 310

Query: 294 STLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKER-QKKDNHN 352
               VSG  +       +AT  + V     AE   I R  + ++A A  + R +K+  HN
Sbjct: 311 LPTLVSGGTI-------LATVPLVVD----AEKLPINRLAAGSKAPASAQSRGEKRTAHN 359

Query: 353 LIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESR 412
            IE+R R +IND+I EL  L+  +   E + NK  +L+ ++DYIR LQ   Q+ K     
Sbjct: 360 AIEKRYRSSINDKIIELKDLVVGT---EAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLS 416

Query: 413 QRSLEQANRSLQ 424
            R+    ++SL+
Sbjct: 417 LRTAVHKSKSLK 428


>gi|22547195 sterol regulatory element binding transcription factor
           1 isoform b [Homo sapiens]
          Length = 1147

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 94/372 (25%), Positives = 140/372 (37%), Gaps = 45/372 (12%)

Query: 60  DPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGG--SRTPAMSSSSSSRVLLR 117
           D  S   L   P  L SSL   L    A P+ LS    A       P+M + S    +  
Sbjct: 65  DTSSPGSLSPPPATLSSSLEAFLSGPQAAPSPLSPPQPAPTPLKMYPSMPAFSPGPGIKE 124

Query: 118 QQLMRAQAQEQERRERREQAAAAPFPSPAP----ASPAISVVGVSAGGHTLSRPPPAQVP 173
           + +  +  Q    +          FP+PAP    ++P +       G  T S P   Q P
Sbjct: 125 ESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGYPSPPGGFSTGSPPGNTQQP 184

Query: 174 REVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEA 233
              L + +    P      Q +    +Q L+ T  P  A    T     +  Q +P    
Sbjct: 185 LPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVT---SQIQQVPVLLQ 241

Query: 234 AHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLP 293
            H          +   LLT   +    +                  LS L  GTT    P
Sbjct: 242 PHFI-------KADSLLLTAMKTDGATVKAA--------------GLSPLVSGTTVQTGP 280

Query: 294 STLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKER-QKKDNHN 352
               VSG  +       +AT  + V     AE   I R  + ++A A  + R +K+  HN
Sbjct: 281 LPTLVSGGTI-------LATVPLVVD----AEKLPINRLAAGSKAPASAQSRGEKRTAHN 329

Query: 353 LIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESR 412
            IE+R R +IND+I EL  L+  +   E + NK  +L+ ++DYIR LQ   Q+ K     
Sbjct: 330 AIEKRYRSSINDKIIELKDLVVGT---EAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLS 386

Query: 413 QRSLEQANRSLQ 424
            R+    ++SL+
Sbjct: 387 LRTAVHKSKSLK 398


>gi|4507847 upstream stimulatory factor 2 isoform 1 [Homo sapiens]
          Length = 346

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 60/226 (26%), Positives = 98/226 (43%), Gaps = 42/226 (18%)

Query: 215 ALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESS 274
           A + PPGPA+  PL   +   + G       SP A                 E +S E+ 
Sbjct: 130 AASVPPGPAAPFPLAVIQNPFSNG------GSPAA-----------------EAVSGEAR 166

Query: 275 YNDEMLSYLP----GGTTGLQLPST---LPVSGNLLDVYSSQGVATPAITVSNSCPAELP 327
           +     +Y P    G TT + + +T   L   G    + + Q V     T     P   P
Sbjct: 167 F-----AYFPASSVGDTTAVSVQTTDQSLQAGGQFYVMMTPQDVLQTG-TQRTIAPRTHP 220

Query: 328 NIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIP--KSSDPEMRWNK 385
               +I  T      ++ +++  HN +ERRRR  IN+ I +L  +IP   + + +   +K
Sbjct: 221 -YSPKIDGTRTP---RDERRRAQHNEVERRRRDKINNWIVQLSKIIPDCNADNSKTGASK 276

Query: 386 GTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELE 431
           G IL  + DYIR+L++  QR ++       L+  N  L+ +I+EL+
Sbjct: 277 GGILSKACDYIRELRQTNQRMQETFKEAERLQMDNELLRQQIEELK 322


>gi|27477113 sterol regulatory element-binding transcription factor
           2 [Homo sapiens]
          Length = 1141

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 84/378 (22%), Positives = 151/378 (39%), Gaps = 66/378 (17%)

Query: 86  PATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSP 145
           P +  + S+S S+G S + +    SSS  +                +R       P  SP
Sbjct: 55  PGSGGSGSSSGSSGSSSSSSNGRGSSSGAV------------DPSVQRSFTQVTLPSFSP 102

Query: 146 APASPAISVVGVSAGGHTLS-----------RPPPAQVPREVLKVQTHLENPTRYHLQQA 194
           + ASP    + V     ++            RP P   P+  L+ QT +  PT     Q 
Sbjct: 103 SAASPQAPTLQVKVSPTSVPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQT 162

Query: 195 RRQQ---VKQYLSTT---LGPKLASQALTPPPGPASAQP-LPAPEAAHTTGPTGSAPNSP 247
           R  Q   + Q  +T+   L P++ S   +    P + Q  +   +A      T +     
Sbjct: 163 RIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQT 222

Query: 248 MALLTIGSSSEKEIDDVI----DEIISLES---------------SYNDEMLSYL--PGG 286
           +A  T+ + +  ++  V      +II  +S               +  +  L+ L  P  
Sbjct: 223 LAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQ 282

Query: 287 TTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQ 346
           T  LQ+P+ +  SG +L          P +      P  +  +   + + E     KE +
Sbjct: 283 TAALQVPTLVGSSGTIL-------TTMPVMMGQEKVP--IKQVPGGVKQLEPP---KEGE 330

Query: 347 KKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRS 406
           ++  HN+IE+R R +IND+I EL  L+   +D +M  +K  +L+ ++DYI+ LQ+   + 
Sbjct: 331 RRTTHNIIEKRYRSSINDKIIELKDLV-MGTDAKM--HKSGVLRKAIDYIKYLQQVNHKL 387

Query: 407 KDLESRQRSLEQANRSLQ 424
           +      +   Q N+ L+
Sbjct: 388 RQENMVLKLANQKNKLLK 405


>gi|46877105 upstream stimulatory factor 2 isoform 2 [Homo sapiens]
          Length = 279

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 30/91 (32%), Positives = 54/91 (59%), Gaps = 2/91 (2%)

Query: 343 KERQKKDNHNLIERRRRFNINDRIKELGTLIP--KSSDPEMRWNKGTILKASVDYIRKLQ 400
           ++ +++  HN +ERRRR  IN+ I +L  +IP   + + +   +KG IL  + DYIR+L+
Sbjct: 165 RDERRRAQHNEVERRRRDKINNWIVQLSKIIPDCNADNSKTGASKGGILSKACDYIRELR 224

Query: 401 KEQQRSKDLESRQRSLEQANRSLQLRIQELE 431
           +  QR ++       L+  N  L+ +I+EL+
Sbjct: 225 QTNQRMQETFKEAERLQMDNELLRQQIEELK 255


>gi|19923312 v-myc myelocytomatosis viral related oncogene,
           neuroblastoma derived [Homo sapiens]
          Length = 464

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 76/344 (22%), Positives = 133/344 (38%), Gaps = 56/344 (16%)

Query: 117 RQQLMRAQAQE-QERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPRE 175
           R++L RA +++ Q  R      + A  P    ASPA    G +AG        PA++   
Sbjct: 123 REKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHP 182

Query: 176 VLK-VQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAA 234
             + V   +  P   + ++          +   GP +AS A    P  A     P P   
Sbjct: 183 AAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGR 242

Query: 235 HTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDE---------IISLE---SSYNDEMLSY 282
            T+G          AL T G  +  + DD  DE         ++++E   SS N + ++ 
Sbjct: 243 QTSG------GDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTT 296

Query: 283 L------------PGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIK 330
                        PG     +L     +    L ++     A P+  V +        IK
Sbjct: 297 FTITVRPKNAALGPGRAQSSEL-----ILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIK 351

Query: 331 REISETEAKALL--------------KERQKKDNHNLIERRRRFNINDRIKELGTLIPKS 376
            E S    K+++              ++ +++ NHN++ER+RR ++      L   +P+ 
Sbjct: 352 SEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPEL 411

Query: 377 SDPEMRWNKGTILKASVDYIRKLQKEQQR----SKDLESRQRSL 416
              E +  K  ILK + +Y+  LQ E+ +     + L++RQ+ L
Sbjct: 412 VKNE-KAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQL 454


>gi|6005934 upstream stimulatory factor 1 isoform 1 [Homo sapiens]
          Length = 310

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 36/116 (31%), Positives = 64/116 (55%), Gaps = 9/116 (7%)

Query: 335 ETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSS--DPEMRWNKGTILKAS 392
           ++EA    ++ +++  HN +ERRRR  IN+ I +L  +IP  S    +   +KG IL  +
Sbjct: 188 KSEAPRTTRDEKRRAQHNEVERRRRDKINNWIVQLSKIIPDCSMESTKSGQSKGGILSKA 247

Query: 393 VDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELE-----LQAQI--HGLPV 441
            DYI++L++   R  +       L+  N  L+ ++++L+     L+AQ+  HGL V
Sbjct: 248 CDYIQELRQSNHRLSEELQGLDQLQLDNDVLRQQVEDLKNKNLLLRAQLRHHGLEV 303


>gi|46877102 upstream stimulatory factor 1 isoform 2 [Homo sapiens]
          Length = 251

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 36/116 (31%), Positives = 64/116 (55%), Gaps = 9/116 (7%)

Query: 335 ETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSS--DPEMRWNKGTILKAS 392
           ++EA    ++ +++  HN +ERRRR  IN+ I +L  +IP  S    +   +KG IL  +
Sbjct: 129 KSEAPRTTRDEKRRAQHNEVERRRRDKINNWIVQLSKIIPDCSMESTKSGQSKGGILSKA 188

Query: 393 VDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELE-----LQAQI--HGLPV 441
            DYI++L++   R  +       L+  N  L+ ++++L+     L+AQ+  HGL V
Sbjct: 189 CDYIQELRQSNHRLSEELQGLDQLQLDNDVLRQQVEDLKNKNLLLRAQLRHHGLEV 244


>gi|14602433 Williams Beuren syndrome chromosome region 14 isoform
           alpha [Homo sapiens]
          Length = 852

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 74/302 (24%), Positives = 120/302 (39%), Gaps = 72/302 (23%)

Query: 134 REQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQ 193
           R Q A+ P  +PA ASP  +     +    L++   A  P + L  +  L + T      
Sbjct: 501 RGQKASPPTLAPATASPPTTA---GSNNPCLTQLLTAAKPEQAL--EPPLVSSTLLRSPG 555

Query: 194 ARRQQVKQYLSTTLGPKLASQALTPPPGPAS---AQPLPAPEAAHTTGPTGSAPNSPMAL 250
           + ++ V ++  T L P  A     PPPGPA+   ++PL  P+A   + P   AP      
Sbjct: 556 SPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPP---AP------ 606

Query: 251 LTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQG 310
               S SE+ +                  LS +PG       P TL V            
Sbjct: 607 ----SGSERRLSGD---------------LSSMPG-------PGTLSVR----------- 629

Query: 311 VATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELG 370
           V+ P   +S   P       R I+   A                E++RRFNI      L 
Sbjct: 630 VSPPQPILSRGRPDSNKTENRRITHISA----------------EQKRRFNIKLGFDTLH 673

Query: 371 TLIPK-SSDPEMRWNKGTILKASVDYIRKLQKEQQ-RSKDLESRQRSLEQANRSLQLRIQ 428
            L+   S+ P ++ +K T L+ + +YI  LQ+E+    ++ +  +  +E+ N ++ L  Q
Sbjct: 674 GLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEIEELNAAINLCQQ 733

Query: 429 EL 430
           +L
Sbjct: 734 QL 735


>gi|91208420 bassoon protein [Homo sapiens]
          Length = 3926

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 53/164 (32%), Positives = 69/164 (42%), Gaps = 24/164 (14%)

Query: 83   QATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPF 142
            Q + A+ A   AS S  GSR     + S    L  +   +AQ Q Q R     QAA  P 
Sbjct: 3707 QPSRASSAYHHASDSKKGSR----QAHSGPAALQSKAEPQAQPQLQGR-----QAAPGPQ 3757

Query: 143  PSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQY 202
             S +P+S  I            SR P  Q  ++ L +Q     P +  L QAR QQ  Q 
Sbjct: 3758 QSQSPSSRQIP-------SGAASRQPQTQQQQQGLGLQ-----PPQQALTQARLQQQSQP 3805

Query: 203  LSTTLGPKLASQALTPPPGPASA---QPLPAPEAAHTTGPTGSA 243
             +    P  +  A  P PGP++A   QP   P A  T G  G+A
Sbjct: 3806 TTRGSAPAASQPAGKPQPGPSTATGPQPAGPPRAEQTNGSKGTA 3849



 Score = 33.1 bits (74), Expect = 0.71
 Identities = 49/196 (25%), Positives = 74/196 (37%), Gaps = 27/196 (13%)

Query: 75  RSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLR-----QQLMRAQAQEQE 129
           R++ P   QA+  TP   S   +   ++ PA   +   R  L+     Q+  R+ +   +
Sbjct: 90  RAASPTPKQASATTPGHESPRETR--AQGPAGQEADGPRRTLQVDSRTQRSGRSPSVSPD 147

Query: 130 RRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRP---PPAQVPREVLKVQTHLENP 186
           R        + P  +P P+S    +   S    T S+P      Q   +V        NP
Sbjct: 148 RGSTPTSPYSVPQIAPLPSSTLCPICKTSDLTSTPSQPNFNTCTQCHNKVCNQCGFNPNP 207

Query: 187 TRYHLQQAR-------RQQVKQYLSTTLGPKLASQ------ALTPPPGPASAQPLPAPEA 233
              HL Q +       + Q    +  T  P+  SQ      AL+P   PA  QPL  P+ 
Sbjct: 208 ---HLTQVKEWLCLNCQMQRALGMDMTTAPRSKSQQQLHSPALSPAHSPAK-QPLGKPDQ 263

Query: 234 AHTTGPTGSAPNSPMA 249
             + GP G  P S  A
Sbjct: 264 ERSRGPGGPQPGSRQA 279



 Score = 30.8 bits (68), Expect = 3.5
 Identities = 47/233 (20%), Positives = 75/233 (32%), Gaps = 35/233 (15%)

Query: 60   DPDSFYELKSQPLPLRSSLPISLQATPATPAT--------------LSASSSAGGSRTPA 105
            DP   +   + P      + +     P TPAT              ++ +S AG  R+P+
Sbjct: 1352 DPLKLHSSPASPSSASKEIGMPFSQGPGTPATTAVAPCPAGLPRGYMTPASPAGSERSPS 1411

Query: 106  MSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLS 165
             SS++ S              E   +     AAA       P S +    G        S
Sbjct: 1412 PSSTAHSYGHSPTTANYGSQTEDLPQAPSGLAAAGRAAREKPLSASDGEGGTPQPSRAYS 1471

Query: 166  RPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASA 225
                +  P   L   +  E+PT              +    +GP+  ++  T  P PA A
Sbjct: 1472 YFASSSPP---LSPSSPSESPT--------------FSPGKMGPRATAEFSTQTPSPAPA 1514

Query: 226  QPLPAPEAAHTTGPT----GSAPNSPMALLTIGSSSEKEIDDVIDEIISLESS 274
              +P    A T  P        P+ P     +   S +E   ++  + S  SS
Sbjct: 1515 SDMPRSPGAPTPSPMVAQGTQTPHRPSTPRLVWQESSQEAPFMVITLASDASS 1567


>gi|114431248 hypothetical protein LOC205717 [Homo sapiens]
          Length = 2245

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 34/105 (32%), Positives = 57/105 (54%), Gaps = 6/105 (5%)

Query: 332 EISETEAKALLKERQK-KDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILK 390
           E++E E     + R+K ++ HN +ER R+  IN  I  +G LIP S  P ++ +K  IL 
Sbjct: 3   EMTENETPTKKQHRKKNRETHNAVERHRKKKINAGINRIGELIPCS--PALKQSKNMILD 60

Query: 391 ASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQ 435
            +  YI +L+++   + +L     + EQA    +LR Q  E+Q +
Sbjct: 61  QAFKYITELKRQ---NDELLLNGGNNEQAEEIKKLRKQLEEIQKE 102


>gi|47717116 MAX interactor 1 isoform b [Homo sapiens]
          Length = 295

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 60/252 (23%), Positives = 114/252 (45%), Gaps = 36/252 (14%)

Query: 219 PPGPASAQPLPAPEAAHTTGPTGSAPNSPMALL--TIGSSSEKEIDDVIDEI-ISLESSY 275
           PP  A+ QP   PE      P G+ P  P + +  T  +S EK I+  +  + I LE++ 
Sbjct: 27  PPAVAAPQPPALPE-----DPAGAKPRCPFSDIFNTSENSMEKHINTFLQNVQILLEAA- 80

Query: 276 NDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISE 335
                SYL      ++  +     G     Y+S   + P+  + +S P    +  ++ S 
Sbjct: 81  -----SYLEQ----IEKENKKCEHG-----YASSFPSMPSPRLQHSKPPRRLSRAQKHSS 126

Query: 336 TEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDY 395
             +      R     HN +E+ RR ++   ++ L  LIP   D       G + KA   +
Sbjct: 127 GSSNTSTANRS---THNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKA-H 182

Query: 396 IRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSA 455
           I+KL++ +++S   + +  +LE+  R L+ R+++L+   ++  + +       S+ +T +
Sbjct: 183 IKKLEEAERKS---QHQLENLEREQRFLKWRLEQLQGPQEMERIRMD------SIGSTIS 233

Query: 456 SDSLKPEQLDIE 467
           SD    E+ +IE
Sbjct: 234 SDRSDSEREEIE 245


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 51/197 (25%), Positives = 73/197 (37%), Gaps = 19/197 (9%)

Query: 68  KSQPLPLRSSLPISLQA-----TPATPA-TLSASSSAGGSRTPAMSSSSSSRVLLRQQLM 121
           K+   P RS+L    +      TP TP+  ++  S A G+       + S+R     +  
Sbjct: 146 KATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGP 205

Query: 122 RAQAQEQERRERREQAAAAPFPSPA------PASPAISVVGVSAGGHTLSRPPPAQVPRE 175
           R            E + AA     A      PAS ++S           S P     PR 
Sbjct: 206 RKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPR- 264

Query: 176 VLKVQTHLENPTRYHLQQARRQQV---KQYLSTTLGPKLASQALTPPPGPASAQPLPAPE 232
                 H   P    LQ  R  QV   ++  +  LGP  +S   TP P    A+P+P P+
Sbjct: 265 ---APAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPD 321

Query: 233 AAHTTGPTGSAPNSPMA 249
            A T  P    P+ P+A
Sbjct: 322 NAATPLPATLPPSPPLA 338



 Score = 37.0 bits (84), Expect = 0.049
 Identities = 34/120 (28%), Positives = 44/120 (36%), Gaps = 6/120 (5%)

Query: 140 APFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKV-QTHLENPTRYHLQQARRQQ 198
           A FP  AP SP+ S+         L+ PPP   P     + Q     P    LQ  RR  
Sbjct: 805 ASFPGQAPFSPSASLPM-----SPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPP 859

Query: 199 VKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSE 258
                ++  GP+L       PP P S  P          G + SA ++P  L    S  E
Sbjct: 860 TPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPE 919



 Score = 36.2 bits (82), Expect = 0.084
 Identities = 70/282 (24%), Positives = 105/282 (37%), Gaps = 48/282 (17%)

Query: 68  KSQPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQE 127
           K++P+P     P    ATP  PATL  S         A  S S+   L        Q   
Sbjct: 313 KARPVP-----PPDNAATPL-PATLPPSPPLATPLPLAPPSPSAPPSL--------QTLP 358

Query: 128 QERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRP----PPAQVPREVLKVQTHL 183
                   QA  +    P  A P++  +      H+L+ P    PP+ +    L+  T L
Sbjct: 359 SPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSL 418

Query: 184 ENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQP----------LPA-PE 232
            +PT         Q    +L  T+ P+    +LT P  PAS  P          LPA P 
Sbjct: 419 GSPTL--------QATHSFL--TMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPP 468

Query: 233 AAHTTGPTGSAPNSPM------ALLTIGS-SSEKEIDDVIDEIISLESSYNDEMLSYLPG 285
              +  P  S  +SP+      AL ++ S S +  +  +I   +  +SS     L   P 
Sbjct: 469 LQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPA 528

Query: 286 GTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELP 327
             T   L +   ++   L   +S  + TP +  +  CPA  P
Sbjct: 529 SLTTPPLENLPSLAPPPLQT-ASAPLTTPHLE-TPPCPAPCP 568


>gi|9945318 MAX binding protein [Homo sapiens]
          Length = 582

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 73/316 (23%), Positives = 117/316 (37%), Gaps = 49/316 (15%)

Query: 218 PPPGPASAQPLP-APEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYN 276
           PPP PA+AQPLP AP      G  G +   P  L +              ++ +      
Sbjct: 104 PPPLPAAAQPLPLAPRQPALVGAPGLSIKEPAPLPS------------RPQVPTPAPLLP 151

Query: 277 DEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIK----RE 332
           D   +  P G+     P   PV    L +    GV  P +      P  L  +K     E
Sbjct: 152 DSKATIPPNGSPKPLQPLPTPV----LTIAPHPGV-QPQLAPQQPPPPTLGTLKLAPAEE 206

Query: 333 ISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKAS 392
           +  +E K        ++ HN +E+ RR ++ +  + L   IP   D   + +  ++L+ +
Sbjct: 207 VKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDD--KKTSNLSVLRTA 264

Query: 393 VDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQEL--ELQAQIHGLPV--------P 442
           + YI+ L++++   K+ E     L +   + Q R+ EL  EL   +  L +         
Sbjct: 265 LRYIQSLKRKE---KEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQ 321

Query: 443 PTPGLLSLATTSASDSLKPEQLDIEEEG--------RPGAATFHVGGGPAQNAPHQQP-- 492
           P     S +T S  +    E ++ +  G        RP          P    P   P  
Sbjct: 322 PEDDQASTSTASEGEDNIDEDMEEDRAGLGPPKLSHRPQPELLKSTLPPPSTTPAPLPPH 381

Query: 493 --PAPPSDALLDLHFP 506
             P P S AL   H P
Sbjct: 382 PHPHPHSVALPPAHLP 397



 Score = 30.8 bits (68), Expect = 3.5
 Identities = 25/112 (22%), Positives = 43/112 (38%), Gaps = 13/112 (11%)

Query: 130 RRERREQAAAAPFPSPAPASPAISVVG------VSAGGHTLSRPPPAQVPREVLKVQTHL 183
           ++++ +Q    P P P PA+PA ++V        +AGG +      A     V++   H+
Sbjct: 399 QQQQPQQKTPLPAPPPPPAAPAQTLVPAPAHLVATAGGGSTVIAHTATTHASVIQTVNHV 458

Query: 184 ENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAH 235
                  LQ    + +     +   P +     TPP G  +  P      AH
Sbjct: 459 -------LQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAH 503


>gi|4758010 clock [Homo sapiens]
          Length = 846

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 24/71 (33%), Positives = 45/71 (63%), Gaps = 3/71 (4%)

Query: 343 KERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKE 402
           K++ K+ + N  E++RR   N  IKELG+++P ++    + +K T+L+ S+D++RK ++ 
Sbjct: 31  KDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNA---RKMDKSTVLQKSIDFLRKHKEI 87

Query: 403 QQRSKDLESRQ 413
             +S   E RQ
Sbjct: 88  TAQSDASEIRQ 98


>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
           2 [Homo sapiens]
          Length = 328

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 26/75 (34%), Positives = 42/75 (56%)

Query: 334 SETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASV 393
           S+ E  +  KER  ++NH+ IERRRR  +   I EL  ++P  S    + +K TIL+ +V
Sbjct: 77  SDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136

Query: 394 DYIRKLQKEQQRSKD 408
            +++ L+     S D
Sbjct: 137 SHMKSLRGTGNTSTD 151


>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
           [Homo sapiens]
          Length = 789

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 26/75 (34%), Positives = 42/75 (56%)

Query: 334 SETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASV 393
           S+ E  +  KER  ++NH+ IERRRR  +   I EL  ++P  S    + +K TIL+ +V
Sbjct: 77  SDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136

Query: 394 DYIRKLQKEQQRSKD 408
            +++ L+     S D
Sbjct: 137 SHMKSLRGTGNTSTD 151


>gi|5453734 MAD4 [Homo sapiens]
          Length = 209

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 26/101 (25%), Positives = 61/101 (60%), Gaps = 5/101 (4%)

Query: 335 ETEAKALLKER-QKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASV 393
           +T+A  L+++    + +HN +E+ RR  +   +++L  L+P   D   R    ++LK + 
Sbjct: 41  KTKAAGLVRKAPNNRSSHNELEKHRRAKLRLYLEQLKQLVPLGPD-STRHTTLSLLKRAK 99

Query: 394 DYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQA 434
            +I+KL+++ +R+  ++ +   L+Q +R L+ R+++L +Q+
Sbjct: 100 VHIKKLEEQDRRALSIKEQ---LQQEHRFLKRRLEQLSVQS 137


>gi|146134388 YLP motif containing 1 [Homo sapiens]
          Length = 2146

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 70/279 (25%), Positives = 106/279 (37%), Gaps = 38/279 (13%)

Query: 86  PATPATLSASSSAGG---SRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPF 142
           P  P  L  +S   G   S TPA + SSS  +  R+Q +    Q Q+  +++ Q    P 
Sbjct: 21  PPPPVALPEASPGPGYSSSTTPA-APSSSGFMSFREQHLAQLQQLQQMHQKQMQCVLQPH 79

Query: 143 PSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQY 202
             P P  P   V  +  GG+   +PPP  +P            P    L   ++QQ K  
Sbjct: 80  HLPPPPLPPPPV--MPGGGYGDWQPPPPPMP-----------PPPGPALSYQKQQQYKHQ 126

Query: 203 L--STTLGP------KLASQALTPPPGPASAQP-----LPAPEAAHT-TGPTGSAPNSPM 248
           +      GP      +L S   +PP  P S  P     +P P+   +   PT S P  P 
Sbjct: 127 MLHHQRDGPPGLVPMELESPPESPPVPPGSYMPPSQSYMPPPQPPPSYYPPTSSQPYLPP 186

Query: 249 ALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSS 308
           A  +   S   +         S  SS +   LS+        Q   + P  G+      S
Sbjct: 187 AQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYLSHSQSYLPSSQASPSRPSQGH----SKS 242

Query: 309 QGVATPAITVSNSCPAELPNIKREISETEAKALLKERQK 347
           Q +A P     ++ P     +++E  E+ AK    E+Q+
Sbjct: 243 QLLAPPP---PSAPPGNKTTVQQEPLESGAKNKSTEQQQ 278



 Score = 30.0 bits (66), Expect = 6.0
 Identities = 47/195 (24%), Positives = 67/195 (34%), Gaps = 27/195 (13%)

Query: 61  PDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQL 120
           P S+Y       P  SS P    A P+   +  + S    + + + SSSSS   L   Q 
Sbjct: 171 PPSYY-------PPTSSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYLSHSQS 223

Query: 121 MRAQAQEQERR----ERREQAAAAPFPSPAPAS-PAISVVGVSAGGHTLSRPPPAQVPRE 175
               +Q    R      + Q  A P PS  P +   +    + +G    S       P  
Sbjct: 224 YLPSSQASPSRPSQGHSKSQLLAPPPPSAPPGNKTTVQQEPLESGAKNKSTEQQQAAPEP 283

Query: 176 VLKVQTHLENPTRYHLQQ--ARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEA 233
                T  E    ++ Q   + +Q+ K +L    G K          GP  A+  P P  
Sbjct: 284 DPSTMTPQEQQQYWYRQHLLSLQQRTKVHLP---GHK---------KGPVVAKDTPEPVK 331

Query: 234 AHTTGP-TGSAPNSP 247
              T P T   P SP
Sbjct: 332 EEVTVPATSQVPESP 346


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 42/136 (30%), Positives = 54/136 (39%), Gaps = 25/136 (18%)

Query: 117 RQQLMRAQAQEQER----RERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQV 172
           RQ+  R +  E+E+    RERR  +AAAP     P +  +     S  G   +   PA+ 
Sbjct: 242 RQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPG-LQAASQPAET 300

Query: 173 PREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPE 232
           P +   V   L  P    L                GP  AS AL PPPGP    PLP   
Sbjct: 301 PSQQGIVLGPLAPPPPPPLPP--------------GPAQASVALPPPPGPPPPPPLP--- 343

Query: 233 AAHTTGPTGSAPNSPM 248
              +TGP    P  P+
Sbjct: 344 ---STGPPPPPPPPPL 356



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 35/175 (20%), Positives = 63/175 (36%), Gaps = 25/175 (14%)

Query: 332 EISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKA 391
           E    E + L +ERQ+++    +ER+ R    +R++    L                   
Sbjct: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERL------------------- 222

Query: 392 SVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLA 451
                R+ Q+ Q+R + LE  +R  ++  R  QL  ++LE + +   +     P  +   
Sbjct: 223 ----DRERQERQERER-LERLERERQERERQEQLEREQLEWERE-RRISSAAAPASVETP 276

Query: 452 TTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPAPPSDALLDLHFP 506
             S        +  ++   +P       G      AP   PP PP  A   +  P
Sbjct: 277 LNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALP 331


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.127    0.350 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,584,215
Number of Sequences: 37866
Number of extensions: 1426157
Number of successful extensions: 14255
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 741
Number of HSP's that attempted gapping in prelim test: 11330
Number of HSP's gapped (non-prelim): 3366
length of query: 575
length of database: 18,247,518
effective HSP length: 108
effective length of query: 467
effective length of database: 14,157,990
effective search space: 6611781330
effective search space used: 6611781330
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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