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Search of human proteins with 84993742
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|84993742 tripartite motif-containing 71 [Homo sapiens]
(868 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|84993742 tripartite motif-containing 71 [Homo sapiens] 1768 0.0
gi|32454739 tripartite motif-containing 3 [Homo sapiens] 321 2e-87
gi|32454737 tripartite motif-containing 3 [Homo sapiens] 321 2e-87
gi|194248081 tripartite motif-containing 2 isoform 2 [Homo sapiens] 310 3e-84
gi|194248079 tripartite motif-containing 2 isoform 1 [Homo sapiens] 310 3e-84
gi|224548921 tripartite motif-containing 45 isoform 1 [Homo sapi... 150 6e-36
gi|224548923 tripartite motif-containing 45 isoform 2 [Homo sapi... 140 4e-33
gi|5032179 tripartite motif-containing 28 protein [Homo sapiens] 108 2e-23
gi|47419911 transcriptional intermediary factor 1 alpha isoform ... 108 3e-23
gi|47419909 transcriptional intermediary factor 1 alpha isoform ... 108 3e-23
gi|74027251 tripartite motif-containing 33 protein isoform beta ... 104 4e-22
gi|74027249 tripartite motif-containing 33 protein isoform alpha... 104 4e-22
gi|209977097 tripartite motif-containing 66 [Homo sapiens] 79 2e-14
gi|134288906 tripartite motif-containing 67 [Homo sapiens] 77 5e-14
gi|153791514 tripartite motif-containing 32 [Homo sapiens] 74 8e-13
gi|153792582 tripartite motif-containing 32 [Homo sapiens] 74 8e-13
gi|30794216 tripartite motif-containing 56 [Homo sapiens] 70 6e-12
gi|54792146 tripartite motif-containing 47 [Homo sapiens] 68 3e-11
gi|40255283 NHL repeat containing 1 [Homo sapiens] 68 4e-11
gi|61098457 NHL repeat containing 3 isoform a [Homo sapiens] 66 1e-10
gi|223890259 midline 2 isoform 2 [Homo sapiens] 65 2e-10
gi|223890257 midline 2 isoform 1 [Homo sapiens] 65 2e-10
gi|62865606 tripartite motif-containing 36 isoform 1 [Homo sapiens] 65 3e-10
gi|19924163 muscle specific ring finger protein 1 [Homo sapiens] 61 4e-09
gi|47174859 tripartite motif-containing 46 [Homo sapiens] 60 9e-09
gi|28195390 tripartite motif-containing 42 [Homo sapiens] 59 1e-08
gi|16519559 tripartite motif protein 9 isoform 2 [Homo sapiens] 58 4e-08
gi|190341104 tripartite motif protein 9 isoform 1 [Homo sapiens] 58 4e-08
gi|21070980 peptidylglycine alpha-amidating monooxygenase isofor... 55 2e-07
gi|62821785 NHL repeat containing 3 isoform b [Homo sapiens] 55 2e-07
>gi|84993742 tripartite motif-containing 71 [Homo sapiens]
Length = 868
Score = 1768 bits (4580), Expect = 0.0
Identities = 868/868 (100%), Positives = 868/868 (100%)
Query: 1 MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVLP 60
MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVLP
Sbjct: 1 MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVLP 60
Query: 61 CLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLL 120
CLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLL
Sbjct: 61 CLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLL 120
Query: 121 DAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPLPQAPQPPAPSRSA 180
DAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPLPQAPQPPAPSRSA
Sbjct: 121 DAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPLPQAPQPPAPSRSA 180
Query: 181 PGGPAASPSALLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIER 240
PGGPAASPSALLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIER
Sbjct: 181 PGGPAASPSALLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIER 240
Query: 241 GPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRE 300
GPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRE
Sbjct: 241 GPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRE 300
Query: 301 CTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVV 360
CTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVV
Sbjct: 301 CTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVV 360
Query: 361 QSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQ 420
QSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQ
Sbjct: 361 QSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQ 420
Query: 421 VLEEGRALDILLARDRMLAQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSS 480
VLEEGRALDILLARDRMLAQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSS
Sbjct: 421 VLEEGRALDILLARDRMLAQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSS 480
Query: 481 GAFAPLTKATGDGLKRALQGKVASFTVIGYDHDGEPRLSGGDLMSAVVLGPDGNLFGAEV 540
GAFAPLTKATGDGLKRALQGKVASFTVIGYDHDGEPRLSGGDLMSAVVLGPDGNLFGAEV
Sbjct: 481 GAFAPLTKATGDGLKRALQGKVASFTVIGYDHDGEPRLSGGDLMSAVVLGPDGNLFGAEV 540
Query: 541 SDQQNGTYVVSYRPQLEGEHLVSVTLCNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEG 600
SDQQNGTYVVSYRPQLEGEHLVSVTLCNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEG
Sbjct: 541 SDQQNGTYVVSYRPQLEGEHLVSVTLCNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEG 600
Query: 601 DSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVA 660
DSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVA
Sbjct: 601 DSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVA 660
Query: 661 CDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTR 720
CDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTR
Sbjct: 661 CDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTR 720
Query: 721 NHRIQLFGPDGVFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQS 780
NHRIQLFGPDGVFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQS
Sbjct: 721 NHRIQLFGPDGVFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQS 780
Query: 781 ARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSGFGQ 840
ARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSGFGQ
Sbjct: 781 ARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSGFGQ 840
Query: 841 MDRPSGIAITPDGMIVVVDFGNNRILVF 868
MDRPSGIAITPDGMIVVVDFGNNRILVF
Sbjct: 841 MDRPSGIAITPDGMIVVVDFGNNRILVF 868
>gi|32454739 tripartite motif-containing 3 [Homo sapiens]
Length = 744
Score = 321 bits (823), Expect = 2e-87
Identities = 220/658 (33%), Positives = 322/658 (48%), Gaps = 54/658 (8%)
Query: 250 AAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGH 309
A QQ G P P LSV R C +H+ + + YC+ C +C EC G H H
Sbjct: 88 AMQQAPDGAHDPEDPHP-LSVVAGRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREH 146
Query: 310 SFIYLQEALQDSRALTIQLLADAQQGR-QAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVT 368
+ L++ ++ +A +Q +A +GR + +I +++Q++ + +++ A
Sbjct: 147 GTVLLRDVVEQHKA-ALQRQLEAVRGRLPQLSAAIALVGGISQQLQERKAEALAQISAAF 205
Query: 369 ARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRAL 428
++AL++R+ L+ +E I K K L Q++ LRQ + S+ S +Q L G A
Sbjct: 206 EDLEQALQQRKQALVSDLETICGAKQKVLQSQLDTLRQGQEHIGSSCSFAEQALRLGSAP 265
Query: 429 DILLARDRMLAQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFG-FVSSGAFAPLT 487
++LL R M ++ L +P E+ ++ L ++ + G +++ A A T
Sbjct: 266 EVLLVRKHMRERLAALAAQAFPERPHENAQLELVLEVDGLRRSVLNLGALLTTSATAHET 325
Query: 488 KATGDGLKRALQGKVASFTVIGYDHDGEPRLSGGDLMSAVVLGPDGNLFGAEVSDQQNGT 547
ATG+GL++AL G+ AS TV D DG +G + A + GPDG V D +NGT
Sbjct: 326 VATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELRAEITGPDGTRLPVPVVDHKNGT 385
Query: 548 YVVSYRPQLEGEHLVSVTLCNQHIENSPFKV-VVKSG----------RSYVGIGLPG--- 593
Y + Y + EGE L+SV L Q + SPF+V ++ G R G PG
Sbjct: 386 YELVYTARTEGELLLSVLLYGQPVRGSPFRVRALRPGDLPPSPDDVKRRVKSPGGPGSHV 445
Query: 594 ----------------------------LSFGSEGDSDGKLCRPWGVSVDKEGYIIVADR 625
GS G G+ GVS G I+VAD
Sbjct: 446 RQKAVRRPSSMYSTGGKRKDNPIEDELVFRVGSRGREKGEFTNLQGVSAASSGRIVVADS 505
Query: 626 SNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQ 685
+N IQVF G F +FG G PGQ RP GVA D + I+VAD DN + IF+ EG+
Sbjct: 506 NNQCIQVFSNEGQFKFRFGVRGRSPGQLQRPTGVAVDTNGDIIVADYDNRWVSIFSPEGK 565
Query: 686 FLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGALWK 745
F K G G+ P VAV+ G I+V D ++ + F P+G + ++G GA +
Sbjct: 566 FKTKIGA-----GRLMGPKGVAVDRNGHIIVVDNKSCCVFTFQPNGKLVGRFGGRGATDR 620
Query: 746 HFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQE 805
HF P VA N++ +VVTDF+NH + V D + GS G GNGQF P GVAVD
Sbjct: 621 HFAGPHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGNGQFNAPTGVAVDSN 680
Query: 806 GRIIVADSRNHRVQMFESNGSFLCKFGAQGSGFGQMDRPSGIAITPDGMIVVVDFGNN 863
G IIVAD N R+Q+F+S+GSFL + P G+A+T DG +VV D GN+
Sbjct: 681 GNIIVADWGNSRIQVFDSSGSFLSYINTSAE---PLYGPQGLALTSDGHVVVADAGNH 735
Score = 60.8 bits (146), Expect = 5e-09
Identities = 43/125 (34%), Positives = 58/125 (46%), Gaps = 6/125 (4%)
Query: 558 GEHLVSVTLCNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDSDGKLCRPWGVSVDKE 617
G H V+V N+ + VK Y G FGS G+ +G+ P GV+VD
Sbjct: 624 GPHFVAVNNKNEIVVTDFHNHSVKV---YSADGEFLFKFGSHGEGNGQFNAPTGVAVDSN 680
Query: 618 GYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRI 677
G IIVAD N+RIQVF G+F T P G+A + +VVAD NH
Sbjct: 681 GNIIVADWGNSRIQVFDSSGSFLSYINTSAE---PLYGPQGLALTSDGHVVVADAGNHCF 737
Query: 678 QIFTF 682
+ + +
Sbjct: 738 KAYRY 742
Score = 52.4 bits (124), Expect = 2e-06
Identities = 35/95 (36%), Positives = 50/95 (52%), Gaps = 16/95 (16%)
Query: 58 VLPCLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLS 117
VLPCLH FC CL+ + +PA + L L CPVC Q +L E G+ AL ++ F +S
Sbjct: 34 VLPCLHTFCERCLQNY-IPA-------QSLTLSCPVCRQTSILPE-QGVSALQNN-FFIS 83
Query: 118 NLLDAVVATAD------EPPPKNGRAGAPAGAGGH 146
+L++A+ D +P P + AG P H
Sbjct: 84 SLMEAMQQAPDGAHDPEDPHPLSVVAGRPLSCPNH 118
>gi|32454737 tripartite motif-containing 3 [Homo sapiens]
Length = 744
Score = 321 bits (823), Expect = 2e-87
Identities = 220/658 (33%), Positives = 322/658 (48%), Gaps = 54/658 (8%)
Query: 250 AAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGH 309
A QQ G P P LSV R C +H+ + + YC+ C +C EC G H H
Sbjct: 88 AMQQAPDGAHDPEDPHP-LSVVAGRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREH 146
Query: 310 SFIYLQEALQDSRALTIQLLADAQQGR-QAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVT 368
+ L++ ++ +A +Q +A +GR + +I +++Q++ + +++ A
Sbjct: 147 GTVLLRDVVEQHKA-ALQRQLEAVRGRLPQLSAAIALVGGISQQLQERKAEALAQISAAF 205
Query: 369 ARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRAL 428
++AL++R+ L+ +E I K K L Q++ LRQ + S+ S +Q L G A
Sbjct: 206 EDLEQALQQRKQALVSDLETICGAKQKVLQSQLDTLRQGQEHIGSSCSFAEQALRLGSAP 265
Query: 429 DILLARDRMLAQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFG-FVSSGAFAPLT 487
++LL R M ++ L +P E+ ++ L ++ + G +++ A A T
Sbjct: 266 EVLLVRKHMRERLAALAAQAFPERPHENAQLELVLEVDGLRRSVLNLGALLTTSATAHET 325
Query: 488 KATGDGLKRALQGKVASFTVIGYDHDGEPRLSGGDLMSAVVLGPDGNLFGAEVSDQQNGT 547
ATG+GL++AL G+ AS TV D DG +G + A + GPDG V D +NGT
Sbjct: 326 VATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELRAEITGPDGTRLPVPVVDHKNGT 385
Query: 548 YVVSYRPQLEGEHLVSVTLCNQHIENSPFKV-VVKSG----------RSYVGIGLPG--- 593
Y + Y + EGE L+SV L Q + SPF+V ++ G R G PG
Sbjct: 386 YELVYTARTEGELLLSVLLYGQPVRGSPFRVRALRPGDLPPSPDDVKRRVKSPGGPGSHV 445
Query: 594 ----------------------------LSFGSEGDSDGKLCRPWGVSVDKEGYIIVADR 625
GS G G+ GVS G I+VAD
Sbjct: 446 RQKAVRRPSSMYSTGGKRKDNPIEDELVFRVGSRGREKGEFTNLQGVSAASSGRIVVADS 505
Query: 626 SNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQ 685
+N IQVF G F +FG G PGQ RP GVA D + I+VAD DN + IF+ EG+
Sbjct: 506 NNQCIQVFSNEGQFKFRFGVRGRSPGQLQRPTGVAVDTNGDIIVADYDNRWVSIFSPEGK 565
Query: 686 FLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGALWK 745
F K G G+ P VAV+ G I+V D ++ + F P+G + ++G GA +
Sbjct: 566 FKTKIGA-----GRLMGPKGVAVDRNGHIIVVDNKSCCVFTFQPNGKLVGRFGGRGATDR 620
Query: 746 HFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQE 805
HF P VA N++ +VVTDF+NH + V D + GS G GNGQF P GVAVD
Sbjct: 621 HFAGPHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGNGQFNAPTGVAVDSN 680
Query: 806 GRIIVADSRNHRVQMFESNGSFLCKFGAQGSGFGQMDRPSGIAITPDGMIVVVDFGNN 863
G IIVAD N R+Q+F+S+GSFL + P G+A+T DG +VV D GN+
Sbjct: 681 GNIIVADWGNSRIQVFDSSGSFLSYINTSAE---PLYGPQGLALTSDGHVVVADAGNH 735
Score = 60.8 bits (146), Expect = 5e-09
Identities = 43/125 (34%), Positives = 58/125 (46%), Gaps = 6/125 (4%)
Query: 558 GEHLVSVTLCNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDSDGKLCRPWGVSVDKE 617
G H V+V N+ + VK Y G FGS G+ +G+ P GV+VD
Sbjct: 624 GPHFVAVNNKNEIVVTDFHNHSVKV---YSADGEFLFKFGSHGEGNGQFNAPTGVAVDSN 680
Query: 618 GYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRI 677
G IIVAD N+RIQVF G+F T P G+A + +VVAD NH
Sbjct: 681 GNIIVADWGNSRIQVFDSSGSFLSYINTSAE---PLYGPQGLALTSDGHVVVADAGNHCF 737
Query: 678 QIFTF 682
+ + +
Sbjct: 738 KAYRY 742
Score = 52.4 bits (124), Expect = 2e-06
Identities = 35/95 (36%), Positives = 50/95 (52%), Gaps = 16/95 (16%)
Query: 58 VLPCLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLS 117
VLPCLH FC CL+ + +PA + L L CPVC Q +L E G+ AL ++ F +S
Sbjct: 34 VLPCLHTFCERCLQNY-IPA-------QSLTLSCPVCRQTSILPE-QGVSALQNN-FFIS 83
Query: 118 NLLDAVVATAD------EPPPKNGRAGAPAGAGGH 146
+L++A+ D +P P + AG P H
Sbjct: 84 SLMEAMQQAPDGAHDPEDPHPLSVVAGRPLSCPNH 118
>gi|194248081 tripartite motif-containing 2 isoform 2 [Homo sapiens]
Length = 744
Score = 310 bits (795), Expect = 3e-84
Identities = 196/632 (31%), Positives = 317/632 (50%), Gaps = 50/632 (7%)
Query: 278 CQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGR- 336
C +HD V+ YC +C +CRECT G H H + L++ ++ +A ++Q+ DA R
Sbjct: 118 CPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKA-SLQVQLDAVNKRL 176
Query: 337 QAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKS 396
I +++ + Q+ + + ++ + +K L R+ LL ++E +K K
Sbjct: 177 PEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKV 236
Query: 397 LYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTVRSLLQPQED 456
L Q++ L Q ++S + Q L G ++LL + +M ++ EL L P+E+
Sbjct: 237 LQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPREN 296
Query: 457 DRVMFTPPDQALYLAIKSFGFV-SSGAFAPLTKATGDGLKRALQGKVASFTVIGYDHDGE 515
D++ F + L +I + G + ++ A A T ATG+GL++ + G+ S T+ D DGE
Sbjct: 297 DQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGE 356
Query: 516 PRLSGGDLMSAVVLGPDGNLFGAEVSDQQNGTYVVSYRPQLEGEHLVSVTLCNQHIENSP 575
+G ++A + PDG++ E+ D +NGTY Y Q EG+ +S+ L +QHI SP
Sbjct: 357 LCKTGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSP 416
Query: 576 FKV-VVKS-----------------GRSYV---GIGLPGLSF------------------ 596
FK+ V++S G +V + P +
Sbjct: 417 FKLKVIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRV 476
Query: 597 GSEGDSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRP 656
G++G + G+ GV+ G I++AD +N +Q+F G F +FG G PGQ RP
Sbjct: 477 GTKGRNKGEFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRP 536
Query: 657 AGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILV 716
GVA S I++AD DN + IF+ +G+F K G +G+ P V+V+ G I+V
Sbjct: 537 TGVAVHPSGDIIIADYDNKWVSIFSSDGKFKTKIG-----SGKLMGPKGVSVDRNGHIIV 591
Query: 717 SDTRNHRIQLFGPDGVFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHP 776
D + + +F P+G + ++G G + F P A N +++TDF+NH + V +
Sbjct: 592 VDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQ 651
Query: 777 DCQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGS 836
+ + GS G GNGQF P GVAVD G IIVAD N R+Q+F+ +GSFL
Sbjct: 652 EGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSAD 711
Query: 837 GFGQMDRPSGIAITPDGMIVVVDFGNNRILVF 868
+ P G+A+T DG +VV D GN+ V+
Sbjct: 712 ---PLYGPQGLALTSDGHVVVADSGNHCFKVY 740
Score = 65.5 bits (158), Expect = 2e-10
Identities = 44/132 (33%), Positives = 62/132 (46%), Gaps = 14/132 (10%)
Query: 555 QLEGEHLVSVTLCNQHI----ENSPFKVVVKSGRSYVGIGLPGLSFGSEGDSDGKLCRPW 610
Q G H +V N+ I N KV + G L FGS G+ +G+ P
Sbjct: 621 QFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFM-------LKFGSNGEGNGQFNAPT 673
Query: 611 GVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVA 670
GV+VD G IIVAD N+RIQVF G+F + + P G+A + +VVA
Sbjct: 674 GVAVDSNGNIIVADWGNSRIQVFDGSGSF---LSYINTSADPLYGPQGLALTSDGHVVVA 730
Query: 671 DKDNHRIQIFTF 682
D NH +++ +
Sbjct: 731 DSGNHCFKVYRY 742
Score = 47.4 bits (111), Expect = 6e-05
Identities = 29/69 (42%), Positives = 40/69 (57%), Gaps = 10/69 (14%)
Query: 58 VLPCLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLS 117
VLPCLH FC CL+ + +PA L L CPVC Q +L E G+ AL ++ F ++
Sbjct: 35 VLPCLHTFCERCLQNY-IPA-------HSLTLSCPVCRQTSILPE-KGVAALQNN-FFIT 84
Query: 118 NLLDAVVAT 126
NL+D + T
Sbjct: 85 NLMDVLQRT 93
>gi|194248079 tripartite motif-containing 2 isoform 1 [Homo sapiens]
Length = 771
Score = 310 bits (795), Expect = 3e-84
Identities = 196/632 (31%), Positives = 317/632 (50%), Gaps = 50/632 (7%)
Query: 278 CQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGR- 336
C +HD V+ YC +C +CRECT G H H + L++ ++ +A ++Q+ DA R
Sbjct: 145 CPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKA-SLQVQLDAVNKRL 203
Query: 337 QAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKS 396
I +++ + Q+ + + ++ + +K L R+ LL ++E +K K
Sbjct: 204 PEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKV 263
Query: 397 LYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTVRSLLQPQED 456
L Q++ L Q ++S + Q L G ++LL + +M ++ EL L P+E+
Sbjct: 264 LQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPREN 323
Query: 457 DRVMFTPPDQALYLAIKSFGFV-SSGAFAPLTKATGDGLKRALQGKVASFTVIGYDHDGE 515
D++ F + L +I + G + ++ A A T ATG+GL++ + G+ S T+ D DGE
Sbjct: 324 DQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGE 383
Query: 516 PRLSGGDLMSAVVLGPDGNLFGAEVSDQQNGTYVVSYRPQLEGEHLVSVTLCNQHIENSP 575
+G ++A + PDG++ E+ D +NGTY Y Q EG+ +S+ L +QHI SP
Sbjct: 384 LCKTGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSP 443
Query: 576 FKV-VVKS-----------------GRSYV---GIGLPGLSF------------------ 596
FK+ V++S G +V + P +
Sbjct: 444 FKLKVIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRV 503
Query: 597 GSEGDSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRP 656
G++G + G+ GV+ G I++AD +N +Q+F G F +FG G PGQ RP
Sbjct: 504 GTKGRNKGEFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRP 563
Query: 657 AGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILV 716
GVA S I++AD DN + IF+ +G+F K G +G+ P V+V+ G I+V
Sbjct: 564 TGVAVHPSGDIIIADYDNKWVSIFSSDGKFKTKIG-----SGKLMGPKGVSVDRNGHIIV 618
Query: 717 SDTRNHRIQLFGPDGVFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHP 776
D + + +F P+G + ++G G + F P A N +++TDF+NH + V +
Sbjct: 619 VDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQ 678
Query: 777 DCQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGS 836
+ + GS G GNGQF P GVAVD G IIVAD N R+Q+F+ +GSFL
Sbjct: 679 EGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSAD 738
Query: 837 GFGQMDRPSGIAITPDGMIVVVDFGNNRILVF 868
+ P G+A+T DG +VV D GN+ V+
Sbjct: 739 ---PLYGPQGLALTSDGHVVVADSGNHCFKVY 767
Score = 65.5 bits (158), Expect = 2e-10
Identities = 44/132 (33%), Positives = 62/132 (46%), Gaps = 14/132 (10%)
Query: 555 QLEGEHLVSVTLCNQHI----ENSPFKVVVKSGRSYVGIGLPGLSFGSEGDSDGKLCRPW 610
Q G H +V N+ I N KV + G L FGS G+ +G+ P
Sbjct: 648 QFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFM-------LKFGSNGEGNGQFNAPT 700
Query: 611 GVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVA 670
GV+VD G IIVAD N+RIQVF G+F + + P G+A + +VVA
Sbjct: 701 GVAVDSNGNIIVADWGNSRIQVFDGSGSF---LSYINTSADPLYGPQGLALTSDGHVVVA 757
Query: 671 DKDNHRIQIFTF 682
D NH +++ +
Sbjct: 758 DSGNHCFKVYRY 769
Score = 47.4 bits (111), Expect = 6e-05
Identities = 29/69 (42%), Positives = 40/69 (57%), Gaps = 10/69 (14%)
Query: 58 VLPCLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLS 117
VLPCLH FC CL+ + +PA L L CPVC Q +L E G+ AL ++ F ++
Sbjct: 62 VLPCLHTFCERCLQNY-IPA-------HSLTLSCPVCRQTSILPE-KGVAALQNN-FFIT 111
Query: 118 NLLDAVVAT 126
NL+D + T
Sbjct: 112 NLMDVLQRT 120
>gi|224548921 tripartite motif-containing 45 isoform 1 [Homo
sapiens]
Length = 580
Score = 150 bits (378), Expect = 6e-36
Identities = 101/387 (26%), Positives = 184/387 (47%), Gaps = 27/387 (6%)
Query: 199 CSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGP 258
C C++ RC C+ +LC C +AH+R + T H + G + +G
Sbjct: 135 CDLCND-REVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKGYSR------IGK 187
Query: 259 PFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSFIYLQEAL 318
P C H E L L+C+ C P+C++C +G H H + +
Sbjct: 188 PI----------------LCPVHPAEELRLFCEFCDRPVCQDCVVGEHREHPCDFTSNVI 231
Query: 319 QDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEER 378
+LL Q +A++ ++ Q + ++ + + V ++V+ + + KA+EE
Sbjct: 232 HKHGDSVWELLKGTQPHVEALEEALAQIHIINSALQKRVEAVAADVRTFSEGYIKAIEEH 291
Query: 379 ECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRML 438
+LL ++E IR K SL LQ +L Q L + + + + +L G L+IL+ + ++
Sbjct: 292 RDKLLKQLEDIRAQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKRVVV 351
Query: 439 AQVQELKTVRSLLQPQEDDRVMFTPPDQA-LYLAIKSFGFVSSGAFAPL-TKATGDGLKR 496
++++L V+ +P +D++ F P ++A + +G +++ P G+ L R
Sbjct: 352 ERLRKLNKVQYSTRPGVNDKIRFCPQEKAGQCRGYEIYGTINTKEVDPAKCVLQGEDLHR 411
Query: 497 ALQGKVASFTVIGYDHDGEPRLSGGDLMSAVVLGPD--GNLFGAEVSDQQNGTYVVSYRP 554
A + + ASFT++ D GE GGD + V+ D + V D ++GTY +SY P
Sbjct: 412 AREKQTASFTLLCKDAAGEIMGRGGDNVQVAVVPKDKKDSPVRTMVQDNKDGTYYISYTP 471
Query: 555 QLEGEHLVSVTLCNQHIENSPFKVVVK 581
+ G + V V + QH++ SPF V+V+
Sbjct: 472 KEPGVYTVWVCIKEQHVQGSPFTVMVR 498
Score = 30.4 bits (67), Expect = 7.4
Identities = 27/86 (31%), Positives = 37/86 (43%), Gaps = 24/86 (27%)
Query: 58 VLPCLHAFCRPCLEAHR----LPAAGG-------GAAGEPLKLR---------CPVCDQK 97
+LPCLH C CLE + GG G+ + LK R CPVCD +
Sbjct: 41 LLPCLHTVCTTCLEQLEPFSVVDIRGGDSDTSSEGSIFQELKPRSLQSQIGILCPVCDAQ 100
Query: 98 VVL----AEAAGMDALPSSAFLLSNL 119
V L +A +D L + +L +L
Sbjct: 101 VDLPMGGVKALTIDHLAVNDVMLESL 126
>gi|224548923 tripartite motif-containing 45 isoform 2 [Homo
sapiens]
Length = 562
Score = 140 bits (354), Expect = 4e-33
Identities = 98/385 (25%), Positives = 177/385 (45%), Gaps = 41/385 (10%)
Query: 199 CSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGP 258
C C++ RC C+ +LC C +AH+R + T H + G + +G
Sbjct: 135 CDLCND-REVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKGYSR------IGK 187
Query: 259 PFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSFIYLQEAL 318
P C H E L L+C+ C P+C++C +G H H + +
Sbjct: 188 PI----------------LCPVHPAEELRLFCEFCDRPVCQDCVVGEHREHPCDFTSNVI 231
Query: 319 QDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEER 378
+LL Q +A++ ++ Q + ++ + + V ++V+ + + KA+EE
Sbjct: 232 HKHGDSVWELLKGTQPHVEALEEALAQIHIINSALQKRVEAVAADVRTFSEGYIKAIEEH 291
Query: 379 ECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRML 438
+LL ++E IR K SL LQ +L Q L + + + + +L G L+IL+ + ++
Sbjct: 292 RDKLLKQLEDIRAQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKRVVV 351
Query: 439 AQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSSGAFAPLTKATGDGLKRAL 498
++++L V+ +P +D++ F P ++A + + L RA
Sbjct: 352 ERLRKLNKVQYSTRPGVNDKIRFCPQEKA--GQCRGYEIYD--------------LHRAR 395
Query: 499 QGKVASFTVIGYDHDGEPRLSGGDLMSAVVLGPD--GNLFGAEVSDQQNGTYVVSYRPQL 556
+ + ASFT++ D GE GGD + V+ D + V D ++GTY +SY P+
Sbjct: 396 EKQTASFTLLCKDAAGEIMGRGGDNVQVAVVPKDKKDSPVRTMVQDNKDGTYYISYTPKE 455
Query: 557 EGEHLVSVTLCNQHIENSPFKVVVK 581
G + V V + QH++ SPF V+V+
Sbjct: 456 PGVYTVWVCIKEQHVQGSPFTVMVR 480
Score = 30.4 bits (67), Expect = 7.4
Identities = 27/86 (31%), Positives = 37/86 (43%), Gaps = 24/86 (27%)
Query: 58 VLPCLHAFCRPCLEAHR----LPAAGG-------GAAGEPLKLR---------CPVCDQK 97
+LPCLH C CLE + GG G+ + LK R CPVCD +
Sbjct: 41 LLPCLHTVCTTCLEQLEPFSVVDIRGGDSDTSSEGSIFQELKPRSLQSQIGILCPVCDAQ 100
Query: 98 VVL----AEAAGMDALPSSAFLLSNL 119
V L +A +D L + +L +L
Sbjct: 101 VDLPMGGVKALTIDHLAVNDVMLESL 126
>gi|5032179 tripartite motif-containing 28 protein [Homo sapiens]
Length = 835
Score = 108 bits (270), Expect = 2e-23
Identities = 100/427 (23%), Positives = 168/427 (39%), Gaps = 46/427 (10%)
Query: 29 SSASSSSSQTSTSSGGGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAAGGGAAGEPLK 88
S+A++S++ S +SG G G G+A A A PA GG A E L+
Sbjct: 4 SAAAASAAAASAASGSPGPGEGSAGGEKRSTAPSAAASASASAAASSPAGGGAEALELLE 63
Query: 89 LRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGAPAGAGGHSN 148
C VC +++ LL L A A P + GA G
Sbjct: 64 -HCGVCRERL---------RPEREPRLLPCLHSACSACLGPAAPAAANSSGDGGAAGDGT 113
Query: 149 HRHHAHHAHPRASASAPPLPQAPQPPAPSRSAPGGPAASPSALLLRRPHGCSSCDEGNAA 208
+ S + + S++A A+ C+SC++ A
Sbjct: 114 VVDCP--VCKQQCFSKDIVENYFMRDSGSKAATDAQDANQC---------CTSCEDNAPA 162
Query: 209 SSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSIL 268
+S C++C E LC+ CV AHQRV+ TKDH + P
Sbjct: 163 TSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKSRDG------------------- 203
Query: 269 SVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSFIYLQEALQDSRALTIQL 328
ER +C H E L L+C++C CR+C + H H + +L++A+++ R L L
Sbjct: 204 ----ERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASL 259
Query: 329 LADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEK 388
+ +Q S ++ ++ QV K VQ +VK + K L +R L+ +K
Sbjct: 260 VKRLGDKHATLQKSTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQK 319
Query: 389 IRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTVR 448
+ + + + L Q + + E + LE +LL++ + Q+ + ++
Sbjct: 320 VTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLH--RALK 377
Query: 449 SLLQPQE 455
++ P E
Sbjct: 378 MIVDPVE 384
Score = 48.5 bits (114), Expect = 3e-05
Identities = 36/106 (33%), Positives = 48/106 (45%), Gaps = 28/106 (26%)
Query: 20 GSPAP----------LSSNSSASSSSSQTSTSSGGGGGGP--------GAAARRLH---- 57
GSP P ++ S+A+S+S+ + SS GGG G RL
Sbjct: 18 GSPGPGEGSAGGEKRSTAPSAAASASASAAASSPAGGGAEALELLEHCGVCRERLRPERE 77
Query: 58 --VLPCLHAFCRPCLEAHRLPAAG----GGAAGEPLKLRCPVCDQK 97
+LPCLH+ C CL AA GGAAG+ + CPVC Q+
Sbjct: 78 PRLLPCLHSACSACLGPAAPAAANSSGDGGAAGDGTVVDCPVCKQQ 123
>gi|47419911 transcriptional intermediary factor 1 alpha isoform a
[Homo sapiens]
Length = 1050
Score = 108 bits (269), Expect = 3e-23
Identities = 66/274 (24%), Positives = 125/274 (45%), Gaps = 19/274 (6%)
Query: 188 PSALLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGA 247
PS+ + + C+SC++ A+ C++C E LC C+RAHQRV+ TKDH +
Sbjct: 152 PSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVR-------- 203
Query: 248 AAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHG 307
Q+ + P G V +R FC H E L LYC+TC CR+C + H
Sbjct: 204 ----QKEEVSPEAVG-------VTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHK 252
Query: 308 GHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAV 367
H + +++EA Q+ + + L+ + + I+ + Q Q +V K V+ ++K
Sbjct: 253 EHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVA 312
Query: 368 TARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRA 427
+ ++ LL ++E + + L Q +++ +LE + + + G +
Sbjct: 313 IFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSS 372
Query: 428 LDILLARDRMLAQVQELKTVRSLLQPQEDDRVMF 461
+L ++ + +++ L R P ++ + F
Sbjct: 373 TALLYSKRLITYRLRHLLRARCDASPVTNNTIQF 406
Score = 37.4 bits (85), Expect = 0.061
Identities = 34/117 (29%), Positives = 45/117 (38%), Gaps = 42/117 (35%)
Query: 23 APLSSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVL------------------PCLHA 64
A S SA+ S + S G G A RL++L PCLH+
Sbjct: 17 AAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSRAPKLLPCLHS 76
Query: 65 FCRPCLEAHR----LPAAGGGAA---------GEPLK-----------LRCPVCDQK 97
FC+ CL A + LPA G+A G P+ +RCPVC Q+
Sbjct: 77 FCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQE 133
Score = 32.3 bits (72), Expect = 2.0
Identities = 32/121 (26%), Positives = 46/121 (38%), Gaps = 30/121 (24%)
Query: 175 APSRSAPGGPAASPS------------------ALLLRRPHGCSSCDEG-NAASSRCLDC 215
A S +A GGP+A+PS A L C+ C + + + + L C
Sbjct: 14 AASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSRAPKLLPC 73
Query: 216 QEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERL 275
C C+ A QR Y+ P G+A + P PG P S S F ++
Sbjct: 74 LHSFCQRCLPAPQR-------YLMLPAPMLGSAETPPPV----PAPGSPVSGSSPFATQV 122
Query: 276 G 276
G
Sbjct: 123 G 123
>gi|47419909 transcriptional intermediary factor 1 alpha isoform b
[Homo sapiens]
Length = 1016
Score = 108 bits (269), Expect = 3e-23
Identities = 66/274 (24%), Positives = 125/274 (45%), Gaps = 19/274 (6%)
Query: 188 PSALLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGA 247
PS+ + + C+SC++ A+ C++C E LC C+RAHQRV+ TKDH +
Sbjct: 152 PSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVR-------- 203
Query: 248 AAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHG 307
Q+ + P G V +R FC H E L LYC+TC CR+C + H
Sbjct: 204 ----QKEEVSPEAVG-------VTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHK 252
Query: 308 GHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAV 367
H + +++EA Q+ + + L+ + + I+ + Q Q +V K V+ ++K
Sbjct: 253 EHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVA 312
Query: 368 TARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRA 427
+ ++ LL ++E + + L Q +++ +LE + + + G +
Sbjct: 313 IFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSS 372
Query: 428 LDILLARDRMLAQVQELKTVRSLLQPQEDDRVMF 461
+L ++ + +++ L R P ++ + F
Sbjct: 373 TALLYSKRLITYRLRHLLRARCDASPVTNNTIQF 406
Score = 37.4 bits (85), Expect = 0.061
Identities = 34/117 (29%), Positives = 45/117 (38%), Gaps = 42/117 (35%)
Query: 23 APLSSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVL------------------PCLHA 64
A S SA+ S + S G G A RL++L PCLH+
Sbjct: 17 AAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSRAPKLLPCLHS 76
Query: 65 FCRPCLEAHR----LPAAGGGAA---------GEPLK-----------LRCPVCDQK 97
FC+ CL A + LPA G+A G P+ +RCPVC Q+
Sbjct: 77 FCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQE 133
Score = 32.3 bits (72), Expect = 2.0
Identities = 32/121 (26%), Positives = 46/121 (38%), Gaps = 30/121 (24%)
Query: 175 APSRSAPGGPAASPS------------------ALLLRRPHGCSSCDEG-NAASSRCLDC 215
A S +A GGP+A+PS A L C+ C + + + + L C
Sbjct: 14 AASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSRAPKLLPC 73
Query: 216 QEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERL 275
C C+ A QR Y+ P G+A + P PG P S S F ++
Sbjct: 74 LHSFCQRCLPAPQR-------YLMLPAPMLGSAETPPPV----PAPGSPVSGSSPFATQV 122
Query: 276 G 276
G
Sbjct: 123 G 123
>gi|74027251 tripartite motif-containing 33 protein isoform beta
[Homo sapiens]
Length = 1110
Score = 104 bits (259), Expect = 4e-22
Identities = 100/450 (22%), Positives = 169/450 (37%), Gaps = 56/450 (12%)
Query: 20 GSPAPLSSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAAG 79
G+ P +A+SS S + SS G G A A P PA G
Sbjct: 58 GAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGG---------AVSTPAPAPASAPAPG 108
Query: 80 GGAA---GEPLKL--RCPVCDQKVVLAEAAGMDALPS-SAFLLSNLLDAVVATADEPPPK 133
A G P L C VC Q + A LP +F L L + P +
Sbjct: 109 PSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPE---------PER 159
Query: 134 NGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPL--PQAPQPPAPSRSAPGGPAASPSAL 191
P G+ G + P+ + Q + +PS+
Sbjct: 160 QLSVPIPGGSNGDIQ----------QVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSS 209
Query: 192 LLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAA 251
+ C+SC++ +A C++C E LC C+ AHQRV+ TKDH I + + A+
Sbjct: 210 DEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGAS 269
Query: 252 QQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSF 311
Q R FC H E L L+C+TC CR+C + H H +
Sbjct: 270 GQ--------------------RPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRY 309
Query: 312 IYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARH 371
+L+EA Q+ + LLA + + + + Q Q ++V K V+ E+K
Sbjct: 310 QFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTL 369
Query: 372 KKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDIL 431
+ ++ LL ++E + + + L Q + +++ ++ + G + +L
Sbjct: 370 INEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALL 429
Query: 432 LARDRMLAQVQELKTVRSLLQPQEDDRVMF 461
++ + Q++ + R P + + F
Sbjct: 430 YSKRLITFQLRHILKARCDPVPAANGAIRF 459
Score = 37.7 bits (86), Expect = 0.046
Identities = 44/174 (25%), Positives = 63/174 (36%), Gaps = 47/174 (27%)
Query: 77 AAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATADEPPPKNGR 136
+ GGG+ P V A AAG A + L + L++ E + GR
Sbjct: 12 SGGGGSGSAP------------VTAGAAGPAAQEAEPPLTAVLVE-------EEEEEGGR 52
Query: 137 AGAPAGAGGHSNHRHHAHHAHPRASASAP-----------------PLPQAPQPPAPSRS 179
AGA GA G + A + +AS+P P P + P PS
Sbjct: 53 AGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAG 112
Query: 180 APGGPAASPSALLLRRPHGCSSCDEG----NAASSRCLDCQEHLCDNCVRAHQR 229
P GP P++LL C+ C + A + L C C C+ +R
Sbjct: 113 PPPGP---PASLL----DTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPER 159
>gi|74027249 tripartite motif-containing 33 protein isoform alpha
[Homo sapiens]
Length = 1127
Score = 104 bits (259), Expect = 4e-22
Identities = 100/450 (22%), Positives = 169/450 (37%), Gaps = 56/450 (12%)
Query: 20 GSPAPLSSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAAG 79
G+ P +A+SS S + SS G G A A P PA G
Sbjct: 58 GAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGG---------AVSTPAPAPASAPAPG 108
Query: 80 GGAA---GEPLKL--RCPVCDQKVVLAEAAGMDALPS-SAFLLSNLLDAVVATADEPPPK 133
A G P L C VC Q + A LP +F L L + P +
Sbjct: 109 PSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPE---------PER 159
Query: 134 NGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPL--PQAPQPPAPSRSAPGGPAASPSAL 191
P G+ G + P+ + Q + +PS+
Sbjct: 160 QLSVPIPGGSNGDIQ----------QVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSS 209
Query: 192 LLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAA 251
+ C+SC++ +A C++C E LC C+ AHQRV+ TKDH I + + A+
Sbjct: 210 DEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGAS 269
Query: 252 QQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSF 311
Q R FC H E L L+C+TC CR+C + H H +
Sbjct: 270 GQ--------------------RPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRY 309
Query: 312 IYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARH 371
+L+EA Q+ + LLA + + + + Q Q ++V K V+ E+K
Sbjct: 310 QFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTL 369
Query: 372 KKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDIL 431
+ ++ LL ++E + + + L Q + +++ ++ + G + +L
Sbjct: 370 INEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALL 429
Query: 432 LARDRMLAQVQELKTVRSLLQPQEDDRVMF 461
++ + Q++ + R P + + F
Sbjct: 430 YSKRLITFQLRHILKARCDPVPAANGAIRF 459
Score = 37.7 bits (86), Expect = 0.046
Identities = 44/174 (25%), Positives = 63/174 (36%), Gaps = 47/174 (27%)
Query: 77 AAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATADEPPPKNGR 136
+ GGG+ P V A AAG A + L + L++ E + GR
Sbjct: 12 SGGGGSGSAP------------VTAGAAGPAAQEAEPPLTAVLVE-------EEEEEGGR 52
Query: 137 AGAPAGAGGHSNHRHHAHHAHPRASASAP-----------------PLPQAPQPPAPSRS 179
AGA GA G + A + +AS+P P P + P PS
Sbjct: 53 AGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAG 112
Query: 180 APGGPAASPSALLLRRPHGCSSCDEG----NAASSRCLDCQEHLCDNCVRAHQR 229
P GP P++LL C+ C + A + L C C C+ +R
Sbjct: 113 PPPGP---PASLL----DTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPER 159
>gi|209977097 tripartite motif-containing 66 [Homo sapiens]
Length = 1216
Score = 79.0 bits (193), Expect = 2e-14
Identities = 57/264 (21%), Positives = 110/264 (41%), Gaps = 19/264 (7%)
Query: 199 CSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGP 258
CS C E AA C C LC +C H+ + GP P A + + GP
Sbjct: 5 CSECKEKRAAHILCTYCNRWLCSSCTEEHRHSP------VPGGPFFPRAQKGSPGVNGGP 58
Query: 259 PFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSFIYLQEAL 318
F++ +C H EVL L+C+TC + C C + H H +++E L
Sbjct: 59 G----DFTL---------YCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVL 105
Query: 319 QDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEER 378
Q+ R L + + ++Q S +Q + +V+ + + V++++K L ++
Sbjct: 106 QNQRMLLEGVTTQVAHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQ 165
Query: 379 ECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRML 438
L+ ++E I + + L Q++ + + E + + + ++ L +++ ++
Sbjct: 166 ANGLIEELEGITNERKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIV 225
Query: 439 AQVQELKTVRSLLQPQEDDRVMFT 462
Q+Q L P + FT
Sbjct: 226 FQMQRLLETSCNTDPGSPWSIRFT 249
>gi|134288906 tripartite motif-containing 67 [Homo sapiens]
Length = 783
Score = 77.4 bits (189), Expect = 5e-14
Identities = 114/523 (21%), Positives = 181/523 (34%), Gaps = 107/523 (20%)
Query: 50 GAAARRLHVLPCLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDAL 109
G+ R +LPC H C PC + G + P Q ++L+ +G+ A
Sbjct: 11 GSLFREPIILPCSHNVCLPCARTIAVQTPDG-------EQHLP---QPLLLSRGSGLQAG 60
Query: 110 PSSAFLLSNLLDAVVATADEPPPKNGRAGAPAGAGGHSNHR------------HHAHHAH 157
++A L + DA A + G GAGG +H + ++
Sbjct: 61 AAAAASLEH--DAAAGPACGGAGGSAAGGLGGGAGGGGDHADKLSLYSETDSGYGSYTPS 118
Query: 158 PRASASAPPLPQAPQPPAPSRSAPGGPAASP----------------------------- 188
++ LP P PP S +A G A S
Sbjct: 119 LKSPNGVRVLPMVPAPPGSSAAAARGAACSSLSSSSSSITCPQCHRSASLDHRGLRGFQR 178
Query: 189 ----SALLLRRPHG---------------CSSCDEG--NAASSRCLDCQEHLCDNC-VRA 226
A++ R G C CD A++ C C C C ++
Sbjct: 179 NRLLEAIVQRYQQGRGAVPGTSAAAAVAICQLCDRTPPEPAATLCEQCDVLYCSACQLKC 238
Query: 227 H-QRVRLTKDHYIERGPPGP----------GAAAAAQQLGLGPPFPGPPF------SILS 269
H R K ++ PP P G A A G G PG S
Sbjct: 239 HPSRGPFAKHRLVQPPPPPPPPAEAASGPTGTAQGAPSGGGGCKSPGGAGAGATGGSTAR 298
Query: 270 VFPERLGFCQHHDDEVLHLYCDTCSVPICREC-TMGRHGGHSFIYLQEALQDSRALTIQL 328
FP C H+ E +YC +C P+C C GRH H L + +A Q
Sbjct: 299 KFPT----CPEHEMENYSMYCVSCRTPVCYLCLEEGRHAKHEVKPLGAMWKQHKAQLSQA 354
Query: 329 LADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEK 388
L + + + Q + + +Q++ ++ + A AL ++ +LL KV K
Sbjct: 355 LNGVSDKAKEAKEFLVQLKNILQQIQENGLDYEACLVAQCDALVDALTRQKAKLLTKVTK 414
Query: 389 IRQVKAKSLYLQVE----KLRQNLNKLESTISAVQQVLEEG--RALDILLARDRMLAQVQ 442
R+ K K ++ Q+ KLRQ+ +E + +++ G + D L+ R QV
Sbjct: 415 EREHKLKMVWDQINHCTLKLRQSTGLMEYCLEVIKENDPSGFLQISDALIKR----VQVS 470
Query: 443 ELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSSGAFAP 485
+ + V+ L+P+ T + L AI F+ P
Sbjct: 471 QEQWVKGALEPKVSAEFDLTLDSEPLLQAIHQLDFIQMKCRVP 513
>gi|153791514 tripartite motif-containing 32 [Homo sapiens]
Length = 653
Score = 73.6 bits (179), Expect = 8e-13
Identities = 77/301 (25%), Positives = 123/301 (40%), Gaps = 48/301 (15%)
Query: 597 GSEGDSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVF-----------KPCGAFHHKFGT 645
G++G + G P + V +G ++VADR N RIQVF P G
Sbjct: 362 GAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLSF 421
Query: 646 LGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWD 705
LG+ P VA + I V D ++ ++++T +G + Q + PW
Sbjct: 422 LGADLPNL-TPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCV------ACHRSQLSKPWG 474
Query: 706 VAVNSEGKILVSDTRNHRIQLFGPD-GVFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVT 764
+ G+ +V+D ++ F D G + KY + + P+ V + EG + T
Sbjct: 475 ITALPSGQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVR----PKFVTCDAEGTVYFT 530
Query: 765 D---------FNNHRLL------VIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQEGRII 809
N H L + PD Q R + + N F G+ VD G +I
Sbjct: 531 QGLGLNLENRQNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLI 590
Query: 810 VADSRNHRVQMFESNG--SFLCKFGAQGSGFGQMDRPSGIAITPDGMIVVVDFGNNRILV 867
VADS + F G S L + G + P GIA+TP G ++V+D ++ I +
Sbjct: 591 VADSSRKEILHFPKGGGYSVLIREG--------LTCPVGIALTPKGQLLVLDCWDHCIKI 642
Query: 868 F 868
+
Sbjct: 643 Y 643
Score = 58.9 bits (141), Expect = 2e-08
Identities = 51/182 (28%), Positives = 77/182 (42%), Gaps = 23/182 (12%)
Query: 686 FLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLF-----------GPDGVFL 734
FL K G KG+ G FN P + V S+G++LV+D N+RIQ+F P G+
Sbjct: 357 FLKKMGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDS 416
Query: 735 NKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQF 794
F GA + +P VA N +G + VTD ++ L V D Q
Sbjct: 417 FVLSFLGADLPNL-TPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCV------ACHRSQL 469
Query: 795 LRPQGVAVDQEGRIIVADSRNHRVQMFE-SNGSFLCKFGAQGSGFGQMDRPSGIAITPDG 853
+P G+ G+ +V D ++ F GS + K+ S RP + +G
Sbjct: 470 SKPWGITALPSGQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAV----RPKFVTCDAEG 525
Query: 854 MI 855
+
Sbjct: 526 TV 527
Score = 42.4 bits (98), Expect = 0.002
Identities = 37/151 (24%), Positives = 65/151 (43%), Gaps = 24/151 (15%)
Query: 732 VFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHP--------------D 777
+FL K G +G+ F+ P + +G ++V D N+R+ V D
Sbjct: 356 LFLKKMGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGID 415
Query: 778 CQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSG 837
FLG++ L P VA++ +G I V DS ++ ++++ +G + +
Sbjct: 416 SFVLSFLGADLPN----LTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRS---- 467
Query: 838 FGQMDRPSGIAITPDGMIVVVDFGNNRILVF 868
Q+ +P GI P G VV D ++ F
Sbjct: 468 --QLSKPWGITALPSGQFVVTDVEGGKLWCF 496
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/102 (27%), Positives = 47/102 (46%), Gaps = 12/102 (11%)
Query: 778 CQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSG 837
C + +G++G+ G F P + V +G ++VAD N+R+Q+F G FL + SG
Sbjct: 355 CLFLKKMGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKG-FLKEIRRSPSG 413
Query: 838 FGQMD-----------RPSGIAITPDGMIVVVDFGNNRILVF 868
P +A+ G+I V D +N + V+
Sbjct: 414 IDSFVLSFLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVY 455
>gi|153792582 tripartite motif-containing 32 [Homo sapiens]
Length = 653
Score = 73.6 bits (179), Expect = 8e-13
Identities = 77/301 (25%), Positives = 123/301 (40%), Gaps = 48/301 (15%)
Query: 597 GSEGDSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVF-----------KPCGAFHHKFGT 645
G++G + G P + V +G ++VADR N RIQVF P G
Sbjct: 362 GAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLSF 421
Query: 646 LGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWD 705
LG+ P VA + I V D ++ ++++T +G + Q + PW
Sbjct: 422 LGADLPNL-TPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCV------ACHRSQLSKPWG 474
Query: 706 VAVNSEGKILVSDTRNHRIQLFGPD-GVFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVT 764
+ G+ +V+D ++ F D G + KY + + P+ V + EG + T
Sbjct: 475 ITALPSGQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVR----PKFVTCDAEGTVYFT 530
Query: 765 D---------FNNHRLL------VIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQEGRII 809
N H L + PD Q R + + N F G+ VD G +I
Sbjct: 531 QGLGLNLENRQNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLI 590
Query: 810 VADSRNHRVQMFESNG--SFLCKFGAQGSGFGQMDRPSGIAITPDGMIVVVDFGNNRILV 867
VADS + F G S L + G + P GIA+TP G ++V+D ++ I +
Sbjct: 591 VADSSRKEILHFPKGGGYSVLIREG--------LTCPVGIALTPKGQLLVLDCWDHCIKI 642
Query: 868 F 868
+
Sbjct: 643 Y 643
Score = 58.9 bits (141), Expect = 2e-08
Identities = 51/182 (28%), Positives = 77/182 (42%), Gaps = 23/182 (12%)
Query: 686 FLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLF-----------GPDGVFL 734
FL K G KG+ G FN P + V S+G++LV+D N+RIQ+F P G+
Sbjct: 357 FLKKMGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDS 416
Query: 735 NKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQF 794
F GA + +P VA N +G + VTD ++ L V D Q
Sbjct: 417 FVLSFLGADLPNL-TPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCV------ACHRSQL 469
Query: 795 LRPQGVAVDQEGRIIVADSRNHRVQMFE-SNGSFLCKFGAQGSGFGQMDRPSGIAITPDG 853
+P G+ G+ +V D ++ F GS + K+ S RP + +G
Sbjct: 470 SKPWGITALPSGQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAV----RPKFVTCDAEG 525
Query: 854 MI 855
+
Sbjct: 526 TV 527
Score = 42.4 bits (98), Expect = 0.002
Identities = 37/151 (24%), Positives = 65/151 (43%), Gaps = 24/151 (15%)
Query: 732 VFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHP--------------D 777
+FL K G +G+ F+ P + +G ++V D N+R+ V D
Sbjct: 356 LFLKKMGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGID 415
Query: 778 CQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSG 837
FLG++ L P VA++ +G I V DS ++ ++++ +G + +
Sbjct: 416 SFVLSFLGADLPN----LTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRS---- 467
Query: 838 FGQMDRPSGIAITPDGMIVVVDFGNNRILVF 868
Q+ +P GI P G VV D ++ F
Sbjct: 468 --QLSKPWGITALPSGQFVVTDVEGGKLWCF 496
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/102 (27%), Positives = 47/102 (46%), Gaps = 12/102 (11%)
Query: 778 CQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSG 837
C + +G++G+ G F P + V +G ++VAD N+R+Q+F G FL + SG
Sbjct: 355 CLFLKKMGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKG-FLKEIRRSPSG 413
Query: 838 FGQMD-----------RPSGIAITPDGMIVVVDFGNNRILVF 868
P +A+ G+I V D +N + V+
Sbjct: 414 IDSFVLSFLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVY 455
>gi|30794216 tripartite motif-containing 56 [Homo sapiens]
Length = 755
Score = 70.5 bits (171), Expect = 6e-12
Identities = 89/352 (25%), Positives = 125/352 (35%), Gaps = 102/352 (28%)
Query: 59 LPCLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLSN 118
LPCLH +C+ CL A GG ++RCP C ++ V G+ + ++ F ++
Sbjct: 34 LPCLHTYCQDCLAQ----LADGG------RVRCPEC-RETVPVPPEGVASFKTN-FFVNG 81
Query: 119 LLDAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPLPQAPQPPAPSR 178
LLD V A A + RAG PA A P
Sbjct: 82 LLDLVKARACG----DLRAGKPACA----------------------------LCPLVGG 109
Query: 179 SAPGGPAASPSALLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYI 238
++ GGPA ++RCLDC + LC C H+ R T H +
Sbjct: 110 TSTGGPA-----------------------TARCLDCADDLCQACADGHRCTRQTHTHRV 146
Query: 239 ERGPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPIC 298
+G + + C H E L C CS +C
Sbjct: 147 ------------VDLVGYRAGWYDE-----EARERQAAQCPQHPGEALRFLCQPCSQLLC 189
Query: 299 RECTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQG-----------RQAIQLSIEQAQ 347
REC + H H + L EA++ R LLA ++A+ EQA
Sbjct: 190 RECRLDPHLDHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQAA 249
Query: 348 TVAEQVEMKAKVV-------QSEVKAVTARHKKALEERECELLWKVEKIRQV 392
V QVE A+ V + EV H +A EE E L ++E QV
Sbjct: 250 RVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQV 301
Score = 34.7 bits (78), Expect = 0.39
Identities = 16/39 (41%), Positives = 23/39 (58%)
Query: 607 CRPWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGT 645
C+P VSVDK+GYI + R N++ + P G+ F T
Sbjct: 679 CQPGSVSVDKKGYIFLTLREVNKVVILDPKGSLLGDFLT 717
>gi|54792146 tripartite motif-containing 47 [Homo sapiens]
Length = 638
Score = 68.2 bits (165), Expect = 3e-11
Identities = 92/392 (23%), Positives = 141/392 (35%), Gaps = 90/392 (22%)
Query: 59 LPCLHAFCRPCLEA---HRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFL 115
LPC H FC CL A HR + GG G RCP+C + P L
Sbjct: 22 LPCGHNFCLACLGALWPHRGASGAGGPGG---AARCPLC-----------QEPFPDGLQL 67
Query: 116 LSN-LLDAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPLPQAPQPP 174
N L ++ P +G APA A P SA + LP P+P
Sbjct: 68 RKNHTLSELLQLRQGSGPGSGPGPAPALA--------------PEPSAPS-ALPSVPEPS 112
Query: 175 APSRSAPGGPAASPSALLLRRPHGCSSCDEGNA--ASSRCLDCQEHLCDNCVRAHQRVRL 232
AP P PA P C +C EG A A+ CL C C + H+R
Sbjct: 113 APCAPEP-WPAG-------EEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPA 164
Query: 233 TKDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDT 292
+ H + PP L C H L YC
Sbjct: 165 LRGHRLV-----------------------PPLRRLEE-----SLCPRH-LRPLERYCRA 195
Query: 293 CSVPICRECTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQ 352
V +C C H GH + L++ A ++L+ + + I Q++
Sbjct: 196 ERVCLCEACAAQEHRGHELVPLEQERALQEAEQSKVLSAVEDRMDELGAGIAQSRRTVAL 255
Query: 353 VEMKAKVVQSEVKAVTARHKKALEERECELLWKVEK-------------IRQVKAKSLYL 399
++ A + V + A AL+ + ++L +E+ RQ + +S
Sbjct: 256 IKSAAVAERERVSRLFADAAAALQGFQTQVLGFIEEGEAAMLGRSQGDLRRQEEQRS--- 312
Query: 400 QVEKLRQNLNKL--ESTISAVQQVLEEGRALD 429
++ + RQNL+++ ++S +Q++L AL+
Sbjct: 313 RLSRARQNLSQVPEADSVSFLQELLALRLALE 344
>gi|40255283 NHL repeat containing 1 [Homo sapiens]
Length = 395
Score = 67.8 bits (164), Expect = 4e-11
Identities = 70/283 (24%), Positives = 108/283 (38%), Gaps = 34/283 (12%)
Query: 604 GKLCRPWGVSV-DKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACD 662
G L P G+++ K G ++V R+++F G H+FG G P V
Sbjct: 124 GTLVNPTGLALCPKTGRVVVVHDGRRRVKIFDSGGGCAHQFGEKGDAAQDIRYPVDVTIT 183
Query: 663 ASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNH 722
+VV D + I++F F GQ L G GQF+ PW V + I+V+D
Sbjct: 184 NDCHVVVTDAGDRSIKVFDFFGQIKLVIG------GQFSLPWGVETTPQNGIVVTDAEAG 237
Query: 723 RIQLFGPD---GVFLNKYGFEGALWKHFDSPRGVAFNH-EGHLVVTDFNNHRLLVIHPDC 778
+ L D GV L H +PRGVA + G + V + H L + C
Sbjct: 238 SLHLLDVDFAEGVLRR----TERLQAHLCNPRGVAVSWLTGAIAVLE---HPLALGTGVC 290
Query: 779 --------QSARFLGSEGTGNGQFLRP-----QGVAVDQEGRIIVADSRNHRVQMFESNG 825
S + +G T P V D +G +IVAD+ +
Sbjct: 291 STRVKVFSSSMQLVGQVDTFGLSLYFPSKITASAVTFDHQGNVIVADTSGPAILCLGKPE 350
Query: 826 SFLCKFGAQGSGFGQMDRPSGIAITPDGMIVVVDFGNNRILVF 868
F G + P + T + ++V+D ++ I V+
Sbjct: 351 EFPVPKPMVTHG---LSHPVALTFTKENSLLVLDTASHSIKVY 390
Score = 59.3 bits (142), Expect = 1e-08
Identities = 63/239 (26%), Positives = 98/239 (41%), Gaps = 23/239 (9%)
Query: 640 HHKFGTLGSRPGQFDRPAGVA-CDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNG 698
HH FG G+ P G+A C + R+VV R++IF G +FGEKG
Sbjct: 117 HHTFGGWGT----LVNPTGLALCPKTGRVVVVHDGRRRVKIFDSGGGCAHQFGEKGDAAQ 172
Query: 699 QFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGALWKHFDSPRGVAFNHE 758
YP DV + ++ ++V+D + I++F G G + F P GV +
Sbjct: 173 DIRYPVDVTITNDCHVVVTDAGDRSIKVFDFFGQIKLVIGGQ------FSLPWGVETTPQ 226
Query: 759 GHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGVAVD-QEGRIIVADSR--- 814
+VVTD L ++ D +E P+GVAV G I V +
Sbjct: 227 NGIVVTDAEAGSLHLLDVDFAEGVLRRTERL-QAHLCNPRGVAVSWLTGAIAVLEHPLAL 285
Query: 815 -----NHRVQMFESNGSFLCKFGAQGSGFGQMDRPSGIAITPD--GMIVVVDFGNNRIL 866
+ RV++F S+ + + G + + A+T D G ++V D IL
Sbjct: 286 GTGVCSTRVKVFSSSMQLVGQVDTFGLSLYFPSKITASAVTFDHQGNVIVADTSGPAIL 344
Score = 48.5 bits (114), Expect = 3e-05
Identities = 27/80 (33%), Positives = 42/80 (52%), Gaps = 1/80 (1%)
Query: 790 GNGQFLRPQGVAV-DQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSGFGQMDRPSGIA 848
G G + P G+A+ + GR++V RV++F+S G +FG +G + P +
Sbjct: 122 GWGTLVNPTGLALCPKTGRVVVVHDGRRRVKIFDSGGGCAHQFGEKGDAAQDIRYPVDVT 181
Query: 849 ITPDGMIVVVDFGNNRILVF 868
IT D +VV D G+ I VF
Sbjct: 182 ITNDCHVVVTDAGDRSIKVF 201
Score = 43.5 bits (101), Expect = 8e-04
Identities = 59/262 (22%), Positives = 108/262 (41%), Gaps = 29/262 (11%)
Query: 578 VVVKSGRSYVGI----GLPGLSFGSEGDSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVF 633
VVV GR V I G FG +GD+ + P V++ + +++V D + I+VF
Sbjct: 142 VVVHDGRRRVKIFDSGGGCAHQFGEKGDAAQDIRYPVDVTITNDCHVVVTDAGDRSIKVF 201
Query: 634 KPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFE-GQFLLKFGE 692
G G GQF P GV IVV D + + + + + +L+ E
Sbjct: 202 DFFGQIKLVIG------GQFSLPWGVETTPQNGIVVTDAEAGSLHLLDVDFAEGVLRRTE 255
Query: 693 KGTKNGQFNYPWDVAVN-SEGKILV--------SDTRNHRIQLFGPDGVFLNKYGFEGAL 743
+ P VAV+ G I V + + R+++F + + G L
Sbjct: 256 R--LQAHLCNPRGVAVSWLTGAIAVLEHPLALGTGVCSTRVKVFSSSMQLVGQVDTFG-L 312
Query: 744 WKHFDS---PRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGV 800
+F S V F+H+G+++V D + +L + + F + P +
Sbjct: 313 SLYFPSKITASAVTFDHQGNVIVADTSGPAILCLG---KPEEFPVPKPMVTHGLSHPVAL 369
Query: 801 AVDQEGRIIVADSRNHRVQMFE 822
+E ++V D+ +H +++++
Sbjct: 370 TFTKENSLLVLDTASHSIKVYK 391
>gi|61098457 NHL repeat containing 3 isoform a [Homo sapiens]
Length = 347
Score = 66.2 bits (160), Expect = 1e-10
Identities = 87/333 (26%), Positives = 138/333 (41%), Gaps = 59/333 (17%)
Query: 544 QNGTYVVSYRPQLEGEHL-VSVTLCNQHIENSPFKVVVKSGRSYVGIG-----LPGLSFG 597
+N T+ VS+R + L V ++ + F V V S V IG +P +
Sbjct: 31 RNFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVF 90
Query: 598 SEGDSDGKLCRPWGVSVDKEGYIIVADRS---------------NNRIQVFKPCGAFHHK 642
+E DG R W +VD I A + ++ + G
Sbjct: 91 TE---DGYFLRAWNYTVDTPHGIFAASTLYEQSVWITDVGSGFFGHTVKKYSSFGDLVQV 147
Query: 643 FGTLGSR-----PGQFDRPAGVACDASRRIVVADKD---NHRIQIFTFEGQFLLKFGEKG 694
GT G + P QFD PA + + + I + D D N+R+ + + L GE G
Sbjct: 148 LGTPGKKGTSLNPLQFDNPAELYVEDTGDIYIVDGDGGLNNRLIKLSQDFMILWLHGENG 207
Query: 695 TKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPD-----GVFLNKYGFEGALWKHFDS 749
T +FN P V ++S G++ V+D N RIQ+F D G + N + EG
Sbjct: 208 TGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWLGAWNNCFTEEG-------- 259
Query: 750 PRGVAFNHEG-HLVVTDFNNHRLLVIHPDCQSARFLGSEGTGN-------GQFLRPQGVA 801
P V F +G +L+V N RL V+ +A +GS G + + P +
Sbjct: 260 PSSVRFTPDGKYLIVAQLNLSRLSVV-----AAPPVGSIGECSVISTIQLADQVLPHLLE 314
Query: 802 VDQE-GRIIVADSRNHRVQMFESNGSFLCKFGA 833
VD++ G + VA+ +VQ + S++ FG+
Sbjct: 315 VDRKTGAVYVAEIGAKQVQKYVPLNSYVPSFGS 347
Score = 59.3 bits (142), Expect = 1e-08
Identities = 49/188 (26%), Positives = 81/188 (43%), Gaps = 28/188 (14%)
Query: 695 TKNGQFNYPWDVAVNSEGKILVSDTR---------------NHRIQLFGPDGVFLNKYGF 739
T++G F W+ V++ I + T H ++ + G + G
Sbjct: 91 TEDGYFLRAWNYTVDTPHGIFAASTLYEQSVWITDVGSGFFGHTVKKYSSFGDLVQVLGT 150
Query: 740 EGALWK-----HFDSPRGVAFNHEGHLVVTDFN---NHRLLVIHPDCQSARFLGSEGTGN 791
G FD+P + G + + D + N+RL+ + D G GTG
Sbjct: 151 PGKKGTSLNPLQFDNPAELYVEDTGDIYIVDGDGGLNNRLIKLSQDFMILWLHGENGTGP 210
Query: 792 GQFLRPQGVAVDQEGRIIVADSRNHRVQMFESN-GSFLCKFGAQGSGFGQMDRPSGIAIT 850
+F P V +D GR+ VAD N R+Q+F+ + G +L GA + F + + PS + T
Sbjct: 211 AKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWL---GAWNNCFTE-EGPSSVRFT 266
Query: 851 PDGMIVVV 858
PDG ++V
Sbjct: 267 PDGKYLIV 274
Score = 40.0 bits (92), Expect = 0.009
Identities = 40/161 (24%), Positives = 65/161 (40%), Gaps = 21/161 (13%)
Query: 723 RIQLFGPDGVFLNKYGFEGALWKHFDSPRGV---AFNHEGHLVVTD----FNNHRLLVIH 775
+I +F DG FL + + D+P G+ + +E + +TD F H +
Sbjct: 86 KILVFTEDGYFLRAWNYT------VDTPHGIFAASTLYEQSVWITDVGSGFFGHTVKKYS 139
Query: 776 PDCQSARFLGSEGTGNG-----QFLRPQGVAVDQEGRIIVADSR---NHRVQMFESNGSF 827
+ LG+ G QF P + V+ G I + D N+R+ +
Sbjct: 140 SFGDLVQVLGTPGKKGTSLNPLQFDNPAELYVEDTGDIYIVDGDGGLNNRLIKLSQDFMI 199
Query: 828 LCKFGAQGSGFGQMDRPSGIAITPDGMIVVVDFGNNRILVF 868
L G G+G + + P + + G + V D GN RI VF
Sbjct: 200 LWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVF 240
>gi|223890259 midline 2 isoform 2 [Homo sapiens]
Length = 705
Score = 65.5 bits (158), Expect = 2e-10
Identities = 69/372 (18%), Positives = 136/372 (36%), Gaps = 76/372 (20%)
Query: 58 VLPCLHAFCRPCLEAHRLPAAGGGAAGEPLK-LRCPVCDQKVVLAEAAGMDALPSSAFLL 116
+LPC H+ C C + + G + EP+ +CP C + V+ G+D L + L
Sbjct: 42 LLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTC-RYVISLNHRGLDGLKRNV-TL 99
Query: 117 SNLLDAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPLPQAPQPPAP 176
N++D +AS S P P +
Sbjct: 100 QNIIDRF----------------------------------QKASVSGPNSPSESRRERT 125
Query: 177 SRSAPGGPAASPSALLLRRPHGCSSCDEG--NAASSRCLDCQEHLCDNCVRA-HQRVRLT 233
R P+ + C C++ A C+ C+ CD C+RA H +
Sbjct: 126 YR---------PTTAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPF 176
Query: 234 KDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTC 293
H + P P + + C H++E +++YC +
Sbjct: 177 TSHRLVE--------------------PVPDTHLRGIT------CLDHENEKVNMYCVSD 210
Query: 294 SVPICRECTM-GRHGGHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQ 352
IC C + GRH H L + + + L + + ++ + + + +Q
Sbjct: 211 DQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQ 270
Query: 353 VEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLE 412
VE+ + ++++ + +++R+ + K+++ + +K + L QV RQ L +
Sbjct: 271 VEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERST 330
Query: 413 STISAVQQVLEE 424
I+ + +L+E
Sbjct: 331 VLINQAEHILKE 342
>gi|223890257 midline 2 isoform 1 [Homo sapiens]
Length = 735
Score = 65.5 bits (158), Expect = 2e-10
Identities = 69/372 (18%), Positives = 136/372 (36%), Gaps = 76/372 (20%)
Query: 58 VLPCLHAFCRPCLEAHRLPAAGGGAAGEPLK-LRCPVCDQKVVLAEAAGMDALPSSAFLL 116
+LPC H+ C C + + G + EP+ +CP C + V+ G+D L + L
Sbjct: 42 LLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTC-RYVISLNHRGLDGLKRNV-TL 99
Query: 117 SNLLDAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPLPQAPQPPAP 176
N++D +AS S P P +
Sbjct: 100 QNIIDRF----------------------------------QKASVSGPNSPSESRRERT 125
Query: 177 SRSAPGGPAASPSALLLRRPHGCSSCDEG--NAASSRCLDCQEHLCDNCVRA-HQRVRLT 233
R P+ + C C++ A C+ C+ CD C+RA H +
Sbjct: 126 YR---------PTTAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPF 176
Query: 234 KDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTC 293
H + P P + + C H++E +++YC +
Sbjct: 177 TSHRLVE--------------------PVPDTHLRGIT------CLDHENEKVNMYCVSD 210
Query: 294 SVPICRECTM-GRHGGHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQ 352
IC C + GRH H L + + + L + + ++ + + + +Q
Sbjct: 211 DQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQ 270
Query: 353 VEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLE 412
VE+ + ++++ + +++R+ + K+++ + +K + L QV RQ L +
Sbjct: 271 VEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERST 330
Query: 413 STISAVQQVLEE 424
I+ + +L+E
Sbjct: 331 VLINQAEHILKE 342
>gi|62865606 tripartite motif-containing 36 isoform 1 [Homo sapiens]
Length = 728
Score = 65.1 bits (157), Expect = 3e-10
Identities = 62/296 (20%), Positives = 117/296 (39%), Gaps = 41/296 (13%)
Query: 199 CSSCDEGNAASSR-CLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLG 257
C C S++ C+DC C+ C + H P AQ +G
Sbjct: 157 CDLCKPPPQESTKSCMDCSASYCNECFKIHH----------------PWGTIKAQHEYVG 200
Query: 258 PPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTM-GRHGGHSFIYLQE 316
P + F ++ C H+ E +++YC+ C P+C C + G H H +
Sbjct: 201 PT---------TNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHANHRVTTMSS 251
Query: 317 A---LQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKK 373
A L++ + I L + ++ I + + ++ E + + E + +
Sbjct: 252 AYKTLKEKLSKDIDYLIGKE---SQVKSQISELNLLMKETECNGERAKEEAITHFEKLFE 308
Query: 374 ALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEE-GRALDILL 432
LEER+ +L ++ ++++ Q+E+ Q L + + Q+VL+E ++ +
Sbjct: 309 VLEERKSSVLKAIDSSKKLRLDKFQTQMEEY-QGLLENNGLVGYAQEVLKETDQSCFVQT 367
Query: 433 ARD---RMLAQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSSGAFAP 485
A+ R+ + LK+ R Q +D V+ T L + F SSG P
Sbjct: 368 AKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTEL---LGELSFFSSGIDVP 420
>gi|19924163 muscle specific ring finger protein 1 [Homo sapiens]
Length = 353
Score = 61.2 bits (147), Expect = 4e-09
Identities = 37/167 (22%), Positives = 72/167 (43%), Gaps = 1/167 (0%)
Query: 278 CQHHDDEVLHLYCDTCSVPICREC-TMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGR 336
C+ H+DE +++YC TC VP C C G H LQ Q + ++ G
Sbjct: 122 CKEHEDEKINIYCLTCEVPTCSMCKVFGIHKACEVAPLQSVFQGQKTELNNCISMLVAGN 181
Query: 337 QAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKS 396
+Q I Q + + + V+ E+ L+E++ ELL ++ + ++ K
Sbjct: 182 DRVQTIITQLEDSRRVTKENSHQVKEELSQKFDTLYAILDEKKSELLQRITQEQEKKLSF 241
Query: 397 LYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQE 443
+ +++ ++ L+K + Q L+E LL +++ + E
Sbjct: 242 IEALIQQYQEQLDKSTKLVETAIQSLDEPGGATFLLTAKQLIKSIVE 288
Score = 30.4 bits (67), Expect = 7.4
Identities = 21/84 (25%), Positives = 34/84 (40%), Gaps = 8/84 (9%)
Query: 58 VLPCLHAFCRPCLEAHRLPA------AGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPS 111
+LPC H CR C A G + + RCP C +V++ + G+ L
Sbjct: 36 ILPCQHNLCRKCANDIFQAANPYWTSRGSSVSMSGGRFRCPTCRHEVIM-DRHGVYGLQR 94
Query: 112 SAFLLSNLLDAVVATADEPPPKNG 135
+ L+ N++D P + G
Sbjct: 95 N-LLVENIIDIYKQECSSRPLQKG 117
>gi|47174859 tripartite motif-containing 46 [Homo sapiens]
Length = 759
Score = 60.1 bits (144), Expect = 9e-09
Identities = 51/218 (23%), Positives = 84/218 (38%), Gaps = 28/218 (12%)
Query: 208 ASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSI 267
A+ C +C+ C+ C + P AQ P
Sbjct: 182 ATKGCTECRATFCNECFKLFH----------------PWGTQKAQH--------EPTLPT 217
Query: 268 LSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGR-HGGHSFIYLQEALQDSRALTI 326
LS P+ L C H +EV H YC TC +C+ C + R H GH + A Q +
Sbjct: 218 LSFRPKGL-MCPDHKEEVTH-YCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLT 275
Query: 327 QLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKV 386
+ L + +Q I + + E+ + + EV + LEE+ LL +
Sbjct: 276 KSLTYILGNQDTVQTQICELEEAVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAI 335
Query: 387 EKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEE 424
E+ +Q + L Q+++ R L+ + Q+VL+E
Sbjct: 336 EECQQERLARLSAQIQEHRSLLDG-SGLVGYAQEVLKE 372
>gi|28195390 tripartite motif-containing 42 [Homo sapiens]
Length = 723
Score = 59.3 bits (142), Expect = 1e-08
Identities = 44/245 (17%), Positives = 94/245 (38%), Gaps = 27/245 (11%)
Query: 199 CSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGP 258
C C A RC+ C+ +LC++C++A +DH
Sbjct: 238 CQVCRNRRIAYKRCITCRLNLCNDCLKAFHSDVAMQDHV--------------------- 276
Query: 259 PFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSFIYLQEAL 318
F S + C HH + YC + +C C H GH I L +A
Sbjct: 277 ------FVDTSAEEQDEKICIHHPSSRIIEYCRNDNKLLCTFCKFSFHNGHDTISLIDAC 330
Query: 319 QDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEER 378
+ A +A + R I + + + + + + E++ + + L+E+
Sbjct: 331 SERAASLFSAIAKFKAVRYEIDNDLMEFNILKNSFKADKEAKRKEIRNGFLKLRSILQEK 390
Query: 379 ECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRML 438
E ++ ++E + + K + V +N+++ I+ ++ L+E + L + ++
Sbjct: 391 EKIIMEQIENLEVSRQKEIEKYVYVTTMKVNEMDGLIAYSKEALKETGQVAFLQSAKILV 450
Query: 439 AQVQE 443
Q+++
Sbjct: 451 DQIED 455
>gi|16519559 tripartite motif protein 9 isoform 2 [Homo sapiens]
Length = 550
Score = 57.8 bits (138), Expect = 4e-08
Identities = 64/293 (21%), Positives = 113/293 (38%), Gaps = 25/293 (8%)
Query: 199 CSSCDEG-NAASSRCLDCQEHLCDNC-VRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGL 256
C C++ A+ C C CD C +R H P GP A L
Sbjct: 168 CQLCEKAPKEATVMCEQCDVFYCDPCRLRCHP-------------PRGPLAKHR-----L 209
Query: 257 GPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICREC-TMGRHGGHSFIYLQ 315
PP G LS P ++ C H+ E +YC C +P+C +C G+H H L
Sbjct: 210 VPPAQGRVSRRLS--PRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALG 267
Query: 316 EALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKAL 375
+ ++ Q L + + + Q + + +Q++ + ++ + A AL
Sbjct: 268 AMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDAL 327
Query: 376 EERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARD 435
R+ +LL +V K + K K + Q+ L + + +V++E L D
Sbjct: 328 NRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISD 387
Query: 436 RMLAQVQ--ELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSSGAFAPL 486
++ +V E + + L P+ + + L +I FV A +P+
Sbjct: 388 ALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPV 440
>gi|190341104 tripartite motif protein 9 isoform 1 [Homo sapiens]
Length = 710
Score = 57.8 bits (138), Expect = 4e-08
Identities = 64/293 (21%), Positives = 113/293 (38%), Gaps = 25/293 (8%)
Query: 199 CSSCDEG-NAASSRCLDCQEHLCDNC-VRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGL 256
C C++ A+ C C CD C +R H P GP A L
Sbjct: 168 CQLCEKAPKEATVMCEQCDVFYCDPCRLRCHP-------------PRGPLAKHR-----L 209
Query: 257 GPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICREC-TMGRHGGHSFIYLQ 315
PP G LS P ++ C H+ E +YC C +P+C +C G+H H L
Sbjct: 210 VPPAQGRVSRRLS--PRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALG 267
Query: 316 EALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKAL 375
+ ++ Q L + + + Q + + +Q++ + ++ + A AL
Sbjct: 268 AMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDAL 327
Query: 376 EERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARD 435
R+ +LL +V K + K K + Q+ L + + +V++E L D
Sbjct: 328 NRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISD 387
Query: 436 RMLAQVQ--ELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSSGAFAPL 486
++ +V E + + L P+ + + L +I FV A +P+
Sbjct: 388 ALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPV 440
>gi|21070980 peptidylglycine alpha-amidating monooxygenase isoform c
preproprotein [Homo sapiens]
Length = 866
Score = 55.5 bits (132), Expect = 2e-07
Identities = 87/383 (22%), Positives = 147/383 (38%), Gaps = 64/383 (16%)
Query: 504 SFTVIGYDHDGEPRLSGGDLMSA--VVLGP---DGNLFGAEVSDQQNGTYVVSYRPQLEG 558
+F +G+ D +S GDL++A V G + G SD+ Y++ Y +E
Sbjct: 268 AFYPVGHPVD----VSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYY---MEA 320
Query: 559 EHLVSVTLCNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDSDGKLCRPWGVSVDKEG 618
+H VS C Q++ F+ + + + + + + K
Sbjct: 321 KHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHEHHKETEYKDKIPLLQQPKRE 380
Query: 619 YIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQ 678
V D+ + + G + PGQ +GVA D +V+ + +H
Sbjct: 381 EEEVLDQDFHMEEALDWPGVY--------LLPGQV---SGVALDPKNNLVIFHRGDHVWD 429
Query: 679 IFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRI-QLFGPDGVFLNKY 737
+F+ +F+ + G E ILV D N + Q G + +L
Sbjct: 430 GNSFDSKFVYQQIGLGPIE-------------EDTILVIDPNNAAVLQSSGKNLFYL--- 473
Query: 738 GFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFL-----GSEGTGNG 792
P G++ + +G+ VTD H++ + P+ + L G+
Sbjct: 474 ------------PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQN 521
Query: 793 QFLRPQGVAVDQ-EGRIIVADSR-NHRVQMFESNGSFLCKFGAQGSGF----GQMDRPSG 846
F +P VAVD G I V+D N R+ F +G F+ ++G + SG GQ P
Sbjct: 522 HFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVPHS 581
Query: 847 IAITP-DGMIVVVDFGNNRILVF 868
+A+ P G + V D N RI F
Sbjct: 582 LALVPLLGQLCVADRENGRIQCF 604
Score = 47.4 bits (111), Expect = 6e-05
Identities = 44/138 (31%), Positives = 69/138 (50%), Gaps = 20/138 (14%)
Query: 609 PWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTL---------GSRPGQFDRPAGV 659
P G+S+DK+G V D + +++ P ++K G + GS F +P V
Sbjct: 474 PHGLSIDKDGNYWVTDVALHQVFKLDP----NNKEGPVLILGRSMQPGSDQNHFCQPTDV 529
Query: 660 ACD-ASRRIVVAD-KDNHRIQIFTFEGQFLLKFGEKGTKN----GQFNYPWDVA-VNSEG 712
A D + I V+D N RI F+ G+F+ ++GE+ + + GQF P +A V G
Sbjct: 530 AVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLG 589
Query: 713 KILVSDTRNHRIQLFGPD 730
++ V+D N RIQ F D
Sbjct: 590 QLCVADRENGRIQCFKTD 607
>gi|62821785 NHL repeat containing 3 isoform b [Homo sapiens]
Length = 280
Score = 55.5 bits (132), Expect = 2e-07
Identities = 43/141 (30%), Positives = 71/141 (50%), Gaps = 24/141 (17%)
Query: 723 RIQLFGPDGVFLNKYGFEGALWKHFDSPRGV---AFNHEGHLVVTDF-NNHRLLVIHPDC 778
+I +F DG FL + + D+P G+ + +E + +TD ++ +L +H
Sbjct: 86 KILVFTEDGYFLRAWNYT------VDTPHGIFAASTLYEQSVWITDVGSDFMILWLH--- 136
Query: 779 QSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESN-GSFLCKFGAQGSG 837
G GTG +F P V +D GR+ VAD N R+Q+F+ + G +L GA +
Sbjct: 137 ------GENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWL---GAWNNC 187
Query: 838 FGQMDRPSGIAITPDGMIVVV 858
F + + PS + TPDG ++V
Sbjct: 188 FTE-EGPSSVRFTPDGKYLIV 207
Score = 50.4 bits (119), Expect = 7e-06
Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 27/157 (17%)
Query: 691 GEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPD-----GVFLNKYGFEGALWK 745
GE GT +FN P V ++S G++ V+D N RIQ+F D G + N + EG
Sbjct: 137 GENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWLGAWNNCFTEEG---- 192
Query: 746 HFDSPRGVAFNHEG-HLVVTDFNNHRLLVIHPDCQSARFLGSEGTGN-------GQFLRP 797
P V F +G +L+V N RL V+ +A +GS G + + P
Sbjct: 193 ----PSSVRFTPDGKYLIVAQLNLSRLSVV-----AAPPVGSIGECSVISTIQLADQVLP 243
Query: 798 QGVAVDQE-GRIIVADSRNHRVQMFESNGSFLCKFGA 833
+ VD++ G + VA+ +VQ + S++ FG+
Sbjct: 244 HLLEVDRKTGAVYVAEIGAKQVQKYVPLNSYVPSFGS 280
Score = 43.5 bits (101), Expect = 8e-04
Identities = 50/183 (27%), Positives = 78/183 (42%), Gaps = 17/183 (9%)
Query: 544 QNGTYVVSYRPQLEGEHL-VSVTLCNQHIENSPFKVVVKSGRSYVGIG-----LPGLSFG 597
+N T+ VS+R + L V ++ + F V V S V IG +P +
Sbjct: 31 RNFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVF 90
Query: 598 SEGDSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGA---FHHKFGTLGSRPGQFD 654
+E DG R W +VD I A + G+ G G+ P +F+
Sbjct: 91 TE---DGYFLRAWNYTVDTPHGIFAASTLYEQSVWITDVGSDFMILWLHGENGTGPAKFN 147
Query: 655 RPAGVACDASRRIVVADKDNHRIQIFTFE-GQFLLKFGEKGTKNGQFNYPWDVAVNSEGK 713
P V D++ R+ VAD+ N RIQ+F + G++L + T+ G P V +GK
Sbjct: 148 IPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWLGAWNNCFTEEG----PSSVRFTPDGK 203
Query: 714 ILV 716
L+
Sbjct: 204 YLI 206
Score = 34.3 bits (77), Expect = 0.51
Identities = 25/83 (30%), Positives = 34/83 (40%), Gaps = 3/83 (3%)
Query: 789 TGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGS---FLCKFGAQGSGFGQMDRPS 845
T +G FLR VD I A + + GS L G G+G + + P
Sbjct: 91 TEDGYFLRAWNYTVDTPHGIFAASTLYEQSVWITDVGSDFMILWLHGENGTGPAKFNIPH 150
Query: 846 GIAITPDGMIVVVDFGNNRILVF 868
+ + G + V D GN RI VF
Sbjct: 151 SVTLDSAGRVWVADRGNKRIQVF 173
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,612,869
Number of Sequences: 37866
Number of extensions: 2135447
Number of successful extensions: 23947
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 229
Number of HSP's successfully gapped in prelim test: 739
Number of HSP's that attempted gapping in prelim test: 18831
Number of HSP's gapped (non-prelim): 4702
length of query: 868
length of database: 18,247,518
effective HSP length: 111
effective length of query: 757
effective length of database: 14,044,392
effective search space: 10631604744
effective search space used: 10631604744
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.