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Search of human proteins with 73695473
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|73695473 roquin [Homo sapiens]
(1133 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|73695473 roquin [Homo sapiens] 2303 0.0
gi|156105697 ring finger and CCCH-type zinc finger domains 2 iso... 997 0.0
gi|156105699 ring finger and CCCH-type zinc finger domains 2 iso... 996 0.0
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 68 6e-11
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom... 66 2e-10
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom... 66 2e-10
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap... 66 2e-10
gi|47132519 Ras association and pleckstrin homology domains 1 is... 64 6e-10
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo... 62 3e-09
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ... 62 3e-09
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 62 4e-09
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 60 9e-09
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 59 2e-08
gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens] 58 6e-08
gi|42544130 splicing factor 1 isoform 1 [Homo sapiens] 57 8e-08
gi|18959210 WIRE protein [Homo sapiens] 57 8e-08
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 57 1e-07
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho... 57 1e-07
gi|110349719 titin isoform N2-A [Homo sapiens] 56 2e-07
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens] 55 4e-07
gi|21361320 TRK-fused [Homo sapiens] 54 8e-07
gi|56090139 TRK-fused [Homo sapiens] 54 8e-07
gi|42544125 splicing factor 1 isoform 2 [Homo sapiens] 54 1e-06
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens] 54 1e-06
gi|112734870 hypothetical protein LOC57648 [Homo sapiens] 54 1e-06
gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens] 53 1e-06
gi|237757312 synaptojanin 1 isoform c [Homo sapiens] 52 2e-06
gi|237757326 synaptojanin 1 isoform d [Homo sapiens] 52 2e-06
gi|155030236 ribonuclease III, nuclear isoform 2 [Homo sapiens] 52 4e-06
gi|155030234 ribonuclease III, nuclear isoform 1 [Homo sapiens] 52 4e-06
>gi|73695473 roquin [Homo sapiens]
Length = 1133
Score = 2303 bits (5967), Expect = 0.0
Identities = 1133/1133 (100%), Positives = 1133/1133 (100%)
Query: 1 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD 60
MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
Sbjct: 1 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD 60
Query: 61 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG 120
IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
Sbjct: 61 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG 120
Query: 121 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS 180
LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
Sbjct: 121 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS 180
Query: 181 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 240
SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
Sbjct: 181 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 240
Query: 241 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP 300
SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
Sbjct: 241 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP 300
Query: 301 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL 360
DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL
Sbjct: 301 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL 360
Query: 361 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR 420
ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
Sbjct: 361 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR 420
Query: 421 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE 480
DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
Sbjct: 421 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE 480
Query: 481 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL 540
GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL
Sbjct: 481 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL 540
Query: 541 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA 600
ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
Sbjct: 541 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA 600
Query: 601 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ 660
PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
Sbjct: 601 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ 660
Query: 661 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP 720
QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
Sbjct: 661 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP 720
Query: 721 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP 780
VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
Sbjct: 721 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP 780
Query: 781 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM 840
TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
Sbjct: 781 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM 840
Query: 841 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA 900
MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
Sbjct: 841 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA 900
Query: 901 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS 960
PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
Sbjct: 901 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS 960
Query: 961 AEREQLRLELQQLNHQISQQTQLRGLEAVSNRLVLQREANTLAGQSQPPPPPPPKWPGMI 1020
AEREQLRLELQQLNHQISQQTQLRGLEAVSNRLVLQREANTLAGQSQPPPPPPPKWPGMI
Sbjct: 961 AEREQLRLELQQLNHQISQQTQLRGLEAVSNRLVLQREANTLAGQSQPPPPPPPKWPGMI 1020
Query: 1021 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT 1080
SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT
Sbjct: 1021 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT 1080
Query: 1081 LTFSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP 1133
LTFSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
Sbjct: 1081 LTFSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP 1133
>gi|156105697 ring finger and CCCH-type zinc finger domains 2 isoform
1 [Homo sapiens]
Length = 1191
Score = 997 bits (2578), Expect = 0.0
Identities = 609/1171 (52%), Positives = 748/1171 (63%), Gaps = 115/1171 (9%)
Query: 1 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD 60
MPVQA QWT+FLSCPIC FDE + KPISLGC HTVCK CLNKLHRKACPFDQT INTD
Sbjct: 1 MPVQAAQWTEFLSCPICYNEFDENVHKPISLGCSHTVCKTCLNKLHRKACPFDQTAINTD 60
Query: 61 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG 120
I++LPVN ALLQLVGAQVP+ Q I L S + + KHYE AKKCVE+LALYLKPLS +GV
Sbjct: 61 IDVLPVNFALLQLVGAQVPDHQSIKL-SNLGENKHYEVAKKCVEDLALYLKPLSGGKGVA 119
Query: 121 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS 180
S QS LSRPMQRKLVTLV+CQLVEEEGR+RAMRAARSLGERTVTELILQHQNPQQLS
Sbjct: 120 --SLNQSALSRPMQRKLVTLVNCQLVEEEGRVRAMRAARSLGERTVTELILQHQNPQQLS 177
Query: 181 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 240
+NLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
Sbjct: 178 ANLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 237
Query: 241 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP 300
SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFR+YEALRREHD+QIV IAMEAGLRI+P
Sbjct: 238 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRSYEALRREHDAQIVHIAMEAGLRISP 297
Query: 301 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL 360
+QWSSLLYGD +HKSHMQSIIDKLQ+P SFA+SVQELTI LQRTGDPANLNRLRPHLELL
Sbjct: 298 EQWSSLLYGDLAHKSHMQSIIDKLQSPESFAKSVQELTIVLQRTGDPANLNRLRPHLELL 357
Query: 361 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR 420
ANIDP+PDA PTWEQLEN +VAV+TVVHGLVD+IQN+S+KG + QP +SKYKT MCR
Sbjct: 358 ANIDPNPDAVSPTWEQLENAMVAVKTVVHGLVDFIQNYSRKGHETPQPQPNSKYKTSMCR 417
Query: 421 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRL---VPRRPLSASLGQLNEVGLPSAAIL 477
D++Q+GGCPRG +CTFAHSQEELEK+R NK++ V PL +G N V + ++
Sbjct: 418 DLRQQGGCPRGTNCTFAHSQEELEKYRLRNKKINATVRTFPLLNKVGVNNTVTTTAGNVI 477
Query: 478 PDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDP---SYDSSLKPGKIDHLSSSAPG 534
G+ + + P+ NGI + N+V+QLI R TD + ++ K GK+ +A G
Sbjct: 478 SVIGSTETTGKIVPS-TNGISNAENSVSQLISRSTDSTLRALETVKKVGKVGANGQNAAG 536
Query: 535 SPPD-LLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQ-------LYPA 586
D + E+ S PV+ + GP++ V L VP+ S +YP
Sbjct: 537 PSADSVTENKIGSPPKTPVSNVAATSAGPSN-----VGTELNSVPQKSSPFLTRVPVYPP 591
Query: 587 QQTDV-YYQDPRGAAPPFEPAPYQQGMYYTPPP-------QCVSRFVR----PPPSAPEP 634
++ Y+QDPR PFE Y Q YY PPP CV RFVR P S P
Sbjct: 592 HSENIQYFQDPR-TQIPFEVPQYPQTGYYPPPPTVPAGVAPCVPRFVRSNNVPESSLPPA 650
Query: 635 APPYLDHYPPYL-QERVVNSQYGTQPQQ----YPPI----YPSHYDGRRVYPAPSYTREE 685
+ PY DHY + ++R+ +S Y P Q PP+ Y YD RR++ P Y R++
Sbjct: 651 SMPYADHYSTFSPRDRMNSSPYQPPPPQPYGPVPPVPSGMYAPVYDSRRIWRPPMYQRDD 710
Query: 686 IFRESPI-PIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPP 744
I R + + P+++ ++V Y RERY ++ YY VA P PS P + +P P
Sbjct: 711 IIRSNSLPPMDVMHSSV--YQTSLRERYNSLDGYYSVACQP----PS----EPRTTVPLP 760
Query: 745 PQP----HPSLDELHRRRKEIMAQLEERK---VISPPPFA-PSPTLP-PTFHPEEFLDED 795
+P S +E RR+ + AQ +K V S P A SPT P P F + D
Sbjct: 761 REPCGHLKTSCEEQIRRKPDQWAQYHTQKAPLVSSTLPVATQSPTPPSPLFSVDFRADFS 820
Query: 796 LKVAG-KYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEMMNVESKGM--RDQR 852
V+G K++ + S YSPWSC TIGS I D++PKDV+A + +M+++S + R
Sbjct: 821 ESVSGTKFEEDHLSHYSPWSCGTIGSCINAIDSEPKDVIANSNAVLMDLDSGDVKRRVHL 880
Query: 853 LDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMAPQGAPTKSINIS 912
+ QRR E +D +IPF D P +S++GAISR+S+T Y P+QA A QG+ TK I++S
Sbjct: 881 FETQRRTKE--EDPIIPFSDGPIISKWGAISRSSRTGYHTTDPVQATASQGSATKPISVS 938
Query: 913 DYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPSAEREQLRLELQQ 972
DY PY S Y S H+ ER+R +++++ H K S+ + L LELQQ
Sbjct: 939 DYVPYVNAVDSRWSSYG--NEATSSAHYVERDRFIVTDLSGHRK--HSSTGDLLSLELQQ 994
Query: 973 LNHQISQQTQLRGLEAVSNRLVLQREANTLAGQSQPPPPPPPKWPGMISSEQLSLELHQV 1032
A SN L+LQREAN LA Q KW + L+L L +
Sbjct: 995 ---------------AKSNSLLLQREANALAMQQ--------KWNSLDEGRHLTLNL--L 1029
Query: 1033 EREIGKRTREL-------SMENQCSLDMKSKLNTSKQAE-NGQPEPQNKV--------PA 1076
+EI R EL + + + D++ +L+ E +GQ EP ++
Sbjct: 1030 SKEIELRNGELQSDYTEDATDTKPDRDIELELSALDTDEPDGQSEPIEEILDIQLGISSQ 1089
Query: 1077 EDLTLTFSDVPNGSALTQENISLLSNKTSSL 1107
D L V NG + Q K SL
Sbjct: 1090 NDQLLNGMAVENGHPVQQHQKEPPKQKKQSL 1120
>gi|156105699 ring finger and CCCH-type zinc finger domains 2 isoform
2 [Homo sapiens]
Length = 1064
Score = 996 bits (2574), Expect = 0.0
Identities = 592/1098 (53%), Positives = 723/1098 (65%), Gaps = 98/1098 (8%)
Query: 1 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD 60
MPVQA QWT+FLSCPIC FDE + KPISLGC HTVCK CLNKLHRKACPFDQT INTD
Sbjct: 1 MPVQAAQWTEFLSCPICYNEFDENVHKPISLGCSHTVCKTCLNKLHRKACPFDQTAINTD 60
Query: 61 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG 120
I++LPVN ALLQLVGAQVP+ Q I L S + + KHYE AKKCVE+LALYLKPLS +GV
Sbjct: 61 IDVLPVNFALLQLVGAQVPDHQSIKL-SNLGENKHYEVAKKCVEDLALYLKPLSGGKGVA 119
Query: 121 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS 180
S QS LSRPMQRKLVTLV+CQLVEEEGR+RAMRAARSLGERTVTELILQHQNPQQLS
Sbjct: 120 --SLNQSALSRPMQRKLVTLVNCQLVEEEGRVRAMRAARSLGERTVTELILQHQNPQQLS 177
Query: 181 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 240
+NLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
Sbjct: 178 ANLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 237
Query: 241 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP 300
SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFR+YEALRREHD+QIV IAMEAGLRI+P
Sbjct: 238 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRSYEALRREHDAQIVHIAMEAGLRISP 297
Query: 301 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL 360
+QWSSLLYGD +HKSHMQSIIDKLQ+P SFA+SVQELTI LQRTGDPANLNRLRPHLELL
Sbjct: 298 EQWSSLLYGDLAHKSHMQSIIDKLQSPESFAKSVQELTIVLQRTGDPANLNRLRPHLELL 357
Query: 361 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR 420
ANIDP+PDA PTWEQLEN +VAV+TVVHGLVD+IQN+S+KG + QP +SKYKT MCR
Sbjct: 358 ANIDPNPDAVSPTWEQLENAMVAVKTVVHGLVDFIQNYSRKGHETPQPQPNSKYKTSMCR 417
Query: 421 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRL---VPRRPLSASLGQLNEVGLPSAAIL 477
D++Q+GGCPRG +CTFAHSQEELEK+R NK++ V PL +G N V + ++
Sbjct: 418 DLRQQGGCPRGTNCTFAHSQEELEKYRLRNKKINATVRTFPLLNKVGVNNTVTTTAGNVI 477
Query: 478 PDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDP---SYDSSLKPGKIDHLSSSAPG 534
G+ + + P+ NGI + N+V+QLI R TD + ++ K GK+ +A G
Sbjct: 478 SVIGSTETTGKIVPS-TNGISNAENSVSQLISRSTDSTLRALETVKKVGKVGANGQNAAG 536
Query: 535 SPPD-LLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQ-------LYPA 586
D + E+ S PV+ + GP++ V L VP+ S +YP
Sbjct: 537 PSADSVTENKIGSPPKTPVSNVAATSAGPSN-----VGTELNSVPQKSSPFLTRVPVYPP 591
Query: 587 QQTDV-YYQDPRGAAPPFEPAPYQQGMYYTPPP-------QCVSRFVR----PPPSAPEP 634
++ Y+QDPR PFE Y Q YY PPP CV RFVR P S P
Sbjct: 592 HSENIQYFQDPR-TQIPFEVPQYPQTGYYPPPPTVPAGVAPCVPRFVRSNNVPESSLPPA 650
Query: 635 APPYLDHYPPYL-QERVVNSQYGTQPQQ----YPPI----YPSHYDGRRVYPAPSYTREE 685
+ PY DHY + ++R+ +S Y P Q PP+ Y YD RR++ P Y R++
Sbjct: 651 SMPYADHYSTFSPRDRMNSSPYQPPPPQPYGPVPPVPSGMYAPVYDSRRIWRPPMYQRDD 710
Query: 686 IFRESPI-PIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPP 744
I R + + P+++ ++V Y RERY ++ YY VA P PS P + +P P
Sbjct: 711 IIRSNSLPPMDVMHSSV--YQTSLRERYNSLDGYYSVACQP----PS----EPRTTVPLP 760
Query: 745 PQP----HPSLDELHRRRKEIMAQLEERK---VISPPPFA-PSPTLP-PTFHPEEFLDED 795
+P S +E RR+ + AQ +K V S P A SPT P P F + D
Sbjct: 761 REPCGHLKTSCEEQIRRKPDQWAQYHTQKAPLVSSTLPVATQSPTPPSPLFSVDFRADFS 820
Query: 796 LKVAG-KYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEMMNVESKGM--RDQR 852
V+G K++ + S YSPWSC TIGS I D++PKDV+A + +M+++S + R
Sbjct: 821 ESVSGTKFEEDHLSHYSPWSCGTIGSCINAIDSEPKDVIANSNAVLMDLDSGDVKRRVHL 880
Query: 853 LDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMAPQGAPTKSINIS 912
+ QRR E +D +IPF D P +S++GAISR+S+T Y P+QA A QG+ TK I++S
Sbjct: 881 FETQRRTKE--EDPIIPFSDGPIISKWGAISRSSRTGYHTTDPVQATASQGSATKPISVS 938
Query: 913 DYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPSAEREQLRLELQQ 972
DY PY S Y S H+ ER+R +++++ H K S+ + L LELQQ
Sbjct: 939 DYVPYVNAVDSRWSSYG--NEATSSAHYVERDRFIVTDLSGHRK--HSSTGDLLSLELQQ 994
Query: 973 LNHQISQQTQLRGLEAVSNRLVLQREANTLAGQSQPPPPPPPKWPGMISSEQLSLELHQV 1032
A SN L+LQREAN LA Q KW + L+L L
Sbjct: 995 ---------------AKSNSLLLQREANALAMQQ--------KWNSLDEGRHLTLNLLSK 1031
Query: 1033 EREI-GKRTRELSMENQC 1049
E E+ ++L++ C
Sbjct: 1032 EIELRNGEVKKLNLSASC 1049
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 67.8 bits (164), Expect = 6e-11
Identities = 96/334 (28%), Positives = 114/334 (34%), Gaps = 45/334 (13%)
Query: 458 PLSASLGQLNEVGLPSAAILPDEGAVDLPSRKPPA-LPNGIVSTGNTVTQLIPRGTDPSY 516
PL SL I P + L S P A L + I+ T + L P
Sbjct: 468 PLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTP- 526
Query: 517 DSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQM 576
+SL +++L S AP PP S P + L P P P PP P+T P
Sbjct: 527 PASLTTPPLENLPSLAP--PPLQTASAPLTTPHLETPP--CPAPCPLQAPPSPLTTPPPE 582
Query: 577 VPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQ-GMYYTPPPQCVSRFVRPPPSAPEPA 635
P P Q P A+PP + P TPPPQ PP AP P+
Sbjct: 583 TPSSIATPPPQ------APPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAP-PS 635
Query: 636 PPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIE 695
PP PP S T Q P H P PS + F P
Sbjct: 636 PP---ASPPL-------SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPV 685
Query: 696 IPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYS-RLPPPPQPHPSLDEL 754
P A PS P S +A P Q+ PS PP S PPPQ P L
Sbjct: 686 SPSATPPSQAPPS------------LAAPPLQVPPSPPASPPMSPSATPPPQAPPPL--- 730
Query: 755 HRRRKEIMAQLEERKVISPPPFAPSPTLPPTFHP 788
Q+ S PP +PS T PP P
Sbjct: 731 ----AAPPLQVPPSPPAS-PPMSPSATPPPRVPP 759
Score = 63.2 bits (152), Expect = 1e-09
Identities = 84/297 (28%), Positives = 105/297 (35%), Gaps = 40/297 (13%)
Query: 490 PPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISA 549
PP P+ I + Q P P P + L++ P +PP L A
Sbjct: 580 PPETPSSIATPP---PQAPPALASPPLQGLPSP-PLSPLATPPPQAPPXL---------A 626
Query: 550 LPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQ 609
LP P PP PA P P+ P P ++ Q P AP PA
Sbjct: 627 LP--PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 684
Query: 610 QGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSH 669
TPP Q PP P P+PP PP S T P Q PP P
Sbjct: 685 VSPSATPPSQAPPSLAAPPLQVP-PSPP---ASPPM-------SPSATPPPQAPP--PLA 731
Query: 670 YDGRRVYPAPSYTREEIFRESPIPIEIPP--AAVPSYVPESRERYQQIESYYPVAPHPTQ 727
+V P+P + +P P +PP AA P VP S + P+A P Q
Sbjct: 732 APPLQVPPSPPASPPMSPSATP-PPRVPPLLAAPPLQVPPSPPASLPMS---PLAKPPPQ 787
Query: 728 IRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSPTLPP 784
P+ L PP LP PP P + A L + +PPP AP P
Sbjct: 788 APPA-LATPPLQALPSPPASFPG-----QAPFSPSASLPMSPLATPPPQAPPVLAAP 838
Score = 42.0 bits (97), Expect = 0.003
Identities = 71/298 (23%), Positives = 91/298 (30%), Gaps = 59/298 (19%)
Query: 509 PRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNP--HSIPPRGPADLP 566
P+G + P + D + P S L P A PV P ++ P PA LP
Sbjct: 274 PKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPL-PATLP 332
Query: 567 PMP-VTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVSRFV 625
P P + PL + P P+ QT P PA TPP Q
Sbjct: 333 PSPPLATPLPLAPPSPSAPPSLQT-----------LPSPPA--------TPPSQAPPSMT 373
Query: 626 RPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREE 685
PP AP P L PP + S P P+ S +P+
Sbjct: 374 TPPMQAP----PSLQTIPPIQVPHSLTSPSLQAPPS--PLALSSLQATTSLGSPTLQATH 427
Query: 686 IF----------------RESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIR 729
F R + P + PP P +P S + P I
Sbjct: 428 SFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIH 487
Query: 730 PSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP---TLPP 784
P S P P L L IM LE + ++PP P T PP
Sbjct: 488 PLQALSSLASHSPQAP-----LSSL------IMPPLETQSSLAPPSLQTPPASLTTPP 534
Score = 39.7 bits (91), Expect = 0.016
Identities = 55/198 (27%), Positives = 67/198 (33%), Gaps = 14/198 (7%)
Query: 468 EVGLPSAAILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDH 527
EVGLP P A P + P S +T PS L+
Sbjct: 186 EVGLPR----PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241
Query: 528 LSSSA-PGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPA 586
LSSSA P S P + P +P P+G L P VT P + L P
Sbjct: 242 LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRK--DAAPALGPL 299
Query: 587 QQTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYL 646
+ + P G P P TP P + PP + P P P PP L
Sbjct: 300 SSSPLATPSPSGTKARPVPPPDNAA---TPLPATLP--PSPPLATPLPLAPPSPSAPPSL 354
Query: 647 QERVVNSQYGTQPQQYPP 664
Q + S T P Q PP
Sbjct: 355 Q--TLPSPPATPPSQAPP 370
Score = 33.1 bits (74), Expect = 1.5
Identities = 40/166 (24%), Positives = 52/166 (31%), Gaps = 14/166 (8%)
Query: 486 PSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSS----APGSPP---- 537
PS PP ++ P + P S+ P ++ L ++ P SPP
Sbjct: 718 PSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLP 777
Query: 538 --DLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQD 595
L + P++ AL P P PA P P +P P Q
Sbjct: 778 MSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 837
Query: 596 PRGAAPPFEPAPYQQGMYYTPPPQCVSRFVRPP----PSAPEPAPP 637
P PP PA PP V P AP P PP
Sbjct: 838 PLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 883
>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
sapiens]
Length = 1188
Score = 66.2 bits (160), Expect = 2e-10
Identities = 87/327 (26%), Positives = 124/327 (37%), Gaps = 43/327 (13%)
Query: 491 PALPNGIVSTGNTVTQLIPRGTDPSYDS--SLKPGKIDH-------LSSSAPGSPPDLLE 541
P++P+ T T + G Y S L+PG+ APG P D+ E
Sbjct: 97 PSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISE 156
Query: 542 SVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAP 601
P S LP P + PP P L P P P M P + A P P
Sbjct: 157 --PPGGSPLPSPPSTAPPPPPLLLEPPP---PPSMAPPPPPVLEALSPPHTLSSPSIPTP 211
Query: 602 PFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPY---LDHYPP-----YLQERVVNS 653
P P + PPP V P P+ P PA P+ +PP + + +N
Sbjct: 212 PDFIPPAPPLAFLAPPPPPV-----PAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNG 266
Query: 654 QYGTQPQQYPPIYPSHYDGRRV--YPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRER 711
+ + PP P+ G + P P T F+ P P + +++P V E++E
Sbjct: 267 RQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPP-PTPVRTSSIP--VQEAQEA 323
Query: 712 YQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSL-DELHR------RRKEIMAQ 764
++ E AP + PS+ P S++ P P P EL R + +Q
Sbjct: 324 PRKEEGATKKAPSRLPLPPSF-HIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQ 382
Query: 765 LEERKVISP--PPF-APSPTLPPTFHP 788
+ER P PP P+P LPP P
Sbjct: 383 ADERAGTPPPAPPLPPPAPPLPPPAPP 409
Score = 34.7 bits (78), Expect = 0.53
Identities = 57/211 (27%), Positives = 71/211 (33%), Gaps = 52/211 (24%)
Query: 472 PSAAILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRG--TDPSYDSSLKPGKIDHLS 529
P A + P V P+ PA P+ + T+L P G T D +L + +
Sbjct: 220 PLAFLAPPPPPVPAPAPPAPASPHTVG------TRLFPPGGVTKWKSDVALNGRQAEATR 273
Query: 530 SSAPGSPPDLLESVPKSISALPVNP--HSIPPRGPADLPPMPV------TKPLQMVPR-- 579
+S P SP + PK SAL NP H PR PP PV + Q PR
Sbjct: 274 ASPPRSPAE-----PKG-SALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKE 327
Query: 580 ---------------------GSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYY---- 614
SQ+YP + + A P P Q
Sbjct: 328 EGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERA 387
Query: 615 -TPPPQCVSRFVRPPPSAPEPAPPYLDHYPP 644
TPPP P P P PAPP PP
Sbjct: 388 GTPPP--APPLPPPAPPLPPPAPPLPPAAPP 416
>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
sapiens]
Length = 1188
Score = 66.2 bits (160), Expect = 2e-10
Identities = 87/327 (26%), Positives = 124/327 (37%), Gaps = 43/327 (13%)
Query: 491 PALPNGIVSTGNTVTQLIPRGTDPSYDS--SLKPGKIDH-------LSSSAPGSPPDLLE 541
P++P+ T T + G Y S L+PG+ APG P D+ E
Sbjct: 97 PSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISE 156
Query: 542 SVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAP 601
P S LP P + PP P L P P P M P + A P P
Sbjct: 157 --PPGGSPLPSPPSTAPPPPPLLLEPPP---PPSMAPPPPPVLEALSPPHTLSSPSIPTP 211
Query: 602 PFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPY---LDHYPP-----YLQERVVNS 653
P P + PPP V P P+ P PA P+ +PP + + +N
Sbjct: 212 PDFIPPAPPLAFLAPPPPPV-----PAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNG 266
Query: 654 QYGTQPQQYPPIYPSHYDGRRV--YPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRER 711
+ + PP P+ G + P P T F+ P P + +++P V E++E
Sbjct: 267 RQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPP-PTPVRTSSIP--VQEAQEA 323
Query: 712 YQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSL-DELHR------RRKEIMAQ 764
++ E AP + PS+ P S++ P P P EL R + +Q
Sbjct: 324 PRKEEGATKKAPSRLPLPPSF-HIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQ 382
Query: 765 LEERKVISP--PPF-APSPTLPPTFHP 788
+ER P PP P+P LPP P
Sbjct: 383 ADERAGTPPPAPPLPPPAPPLPPPAPP 409
Score = 34.7 bits (78), Expect = 0.53
Identities = 57/211 (27%), Positives = 71/211 (33%), Gaps = 52/211 (24%)
Query: 472 PSAAILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRG--TDPSYDSSLKPGKIDHLS 529
P A + P V P+ PA P+ + T+L P G T D +L + +
Sbjct: 220 PLAFLAPPPPPVPAPAPPAPASPHTVG------TRLFPPGGVTKWKSDVALNGRQAEATR 273
Query: 530 SSAPGSPPDLLESVPKSISALPVNP--HSIPPRGPADLPPMPV------TKPLQMVPR-- 579
+S P SP + PK SAL NP H PR PP PV + Q PR
Sbjct: 274 ASPPRSPAE-----PKG-SALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKE 327
Query: 580 ---------------------GSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYY---- 614
SQ+YP + + A P P Q
Sbjct: 328 EGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERA 387
Query: 615 -TPPPQCVSRFVRPPPSAPEPAPPYLDHYPP 644
TPPP P P P PAPP PP
Sbjct: 388 GTPPP--APPLPPPAPPLPPPAPPLPPAAPP 416
>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo
sapiens]
Length = 1188
Score = 66.2 bits (160), Expect = 2e-10
Identities = 87/327 (26%), Positives = 124/327 (37%), Gaps = 43/327 (13%)
Query: 491 PALPNGIVSTGNTVTQLIPRGTDPSYDS--SLKPGKIDH-------LSSSAPGSPPDLLE 541
P++P+ T T + G Y S L+PG+ APG P D+ E
Sbjct: 97 PSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISE 156
Query: 542 SVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAP 601
P S LP P + PP P L P P P M P + A P P
Sbjct: 157 --PPGGSPLPSPPSTAPPPPPLLLEPPP---PPSMAPPPPPVLEALSPPHTLSSPSIPTP 211
Query: 602 PFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPY---LDHYPP-----YLQERVVNS 653
P P + PPP V P P+ P PA P+ +PP + + +N
Sbjct: 212 PDFIPPAPPLAFLAPPPPPV-----PAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNG 266
Query: 654 QYGTQPQQYPPIYPSHYDGRRV--YPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRER 711
+ + PP P+ G + P P T F+ P P + +++P V E++E
Sbjct: 267 RQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPP-PTPVRTSSIP--VQEAQEA 323
Query: 712 YQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSL-DELHR------RRKEIMAQ 764
++ E AP + PS+ P S++ P P P EL R + +Q
Sbjct: 324 PRKEEGATKKAPSRLPLPPSF-HIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQ 382
Query: 765 LEERKVISP--PPF-APSPTLPPTFHP 788
+ER P PP P+P LPP P
Sbjct: 383 ADERAGTPPPAPPLPPPAPPLPPPAPP 409
Score = 34.7 bits (78), Expect = 0.53
Identities = 57/211 (27%), Positives = 71/211 (33%), Gaps = 52/211 (24%)
Query: 472 PSAAILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRG--TDPSYDSSLKPGKIDHLS 529
P A + P V P+ PA P+ + T+L P G T D +L + +
Sbjct: 220 PLAFLAPPPPPVPAPAPPAPASPHTVG------TRLFPPGGVTKWKSDVALNGRQAEATR 273
Query: 530 SSAPGSPPDLLESVPKSISALPVNP--HSIPPRGPADLPPMPV------TKPLQMVPR-- 579
+S P SP + PK SAL NP H PR PP PV + Q PR
Sbjct: 274 ASPPRSPAE-----PKG-SALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKE 327
Query: 580 ---------------------GSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYY---- 614
SQ+YP + + A P P Q
Sbjct: 328 EGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERA 387
Query: 615 -TPPPQCVSRFVRPPPSAPEPAPPYLDHYPP 644
TPPP P P P PAPP PP
Sbjct: 388 GTPPP--APPLPPPAPPLPPPAPPLPPAAPP 416
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 64.3 bits (155), Expect = 6e-10
Identities = 72/289 (24%), Positives = 104/289 (35%), Gaps = 62/289 (21%)
Query: 476 ILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDS------SLKPGKIDHLS 529
++P G V P PP + G+ + QL P PS LK ++ H++
Sbjct: 702 LVPPNGVVPPPPPPPPP-----PTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHIT 756
Query: 530 SSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQT 589
AP +PP PP PA LPP KPL +P +
Sbjct: 757 QVAPPTPPP-------------------PPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPV 797
Query: 590 DVYYQDPRGAAPPFEPAPYQQGM--YYTPPPQCVSRFVRPPPSAPE-------PAPPYLD 640
V P PP PA Q Y PP PPP+ P+ P P L
Sbjct: 798 -VTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLS 856
Query: 641 HYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAA 700
P +++ + SQ+ PP P + + + P P+ + +SP ++ P
Sbjct: 857 PVPSVVKQ--IASQFP------PPPTPPAMESQPLKPVPA----NVAPQSPPAVKAKPKW 904
Query: 701 VPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHP 749
PS +P + P P + + P PP S +P PP P P
Sbjct: 905 QPSSIPVPSPDFP------PPPPESSLVFPP----PPPSPVPAPPPPPP 943
Score = 42.0 bits (97), Expect = 0.003
Identities = 66/290 (22%), Positives = 92/290 (31%), Gaps = 65/290 (22%)
Query: 554 PHSIPPRGPADLPPMPVTKPLQMVPRGSQLYP--------------AQQTDVYYQ----- 594
P PP P PP P P Q P P +Q + ++
Sbjct: 631 PPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPP 690
Query: 595 -------------DPRGAAPP----------------FEPAPYQQGM--YYTPPPQC--- 620
P G PP +PAP + + PPP
Sbjct: 691 VMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIH 750
Query: 621 -VSRFVRPPPSAPEPAPPYLDHYPPYLQER-VVNSQYGTQPQQYPPIYPSHYDGRRVYPA 678
V + P P P PP PP + +V T + P+ P
Sbjct: 751 QVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPV 810
Query: 679 PSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPY 738
P ++ F S IP P VP VP QQ P P P PS +++
Sbjct: 811 PPAKKQPAFPASYIPPSPPTPPVP--VPPPTLPKQQSFCAKP-PPSPLSPVPSVVKQIA- 866
Query: 739 SRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSPTLPPTFHP 788
S+ PPPP P P+++ + K + A + + SPP P P+ P
Sbjct: 867 SQFPPPPTP-PAMES--QPLKPVPANVAPQ---SPPAVKAKPKWQPSSIP 910
Score = 38.1 bits (87), Expect = 0.048
Identities = 41/157 (26%), Positives = 59/157 (37%), Gaps = 24/157 (15%)
Query: 486 PSRKPPALPNGIVSTGNTVTQL-IPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVP 544
P++K PA P + + +P T P S + P SP + SV
Sbjct: 812 PAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQS---------FCAKPPPSPLSPVPSVV 862
Query: 545 KSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRG--SQLYPAQQTDVYYQDPR--GAA 600
K I++ PP PP ++PL+ VP Q PA + +Q +
Sbjct: 863 KQIAS------QFPP---PPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPS 913
Query: 601 PPFEPAPYQQGMYYTPPPQC-VSRFVRPPPSAPEPAP 636
P F P P + + + PPP V PPP P P
Sbjct: 914 PDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTP 950
Score = 34.3 bits (77), Expect = 0.69
Identities = 67/281 (23%), Positives = 93/281 (33%), Gaps = 58/281 (20%)
Query: 509 PRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPM 568
P P+ D S PGK +SS G P SI + H P R D
Sbjct: 943 PPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVS 1002
Query: 569 PVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFE----------PAPYQQGMYYTPPP 618
T P + GS P+++T P AAPP P QQG P
Sbjct: 1003 KFTPPAE---SGS---PSKET-----LPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAP 1051
Query: 619 -------QCVSRFVRPPPSAPEPAPPYLDHYP-PYLQERVVNS--------QYGTQPQQY 662
V F PP + P PP P P ++ V S QPQQ+
Sbjct: 1052 VLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQW 1111
Query: 663 ---------PPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQ 713
PP P D R+ T+ EI + + +P VP S +
Sbjct: 1112 SKMSVKKAPPPTRPKRNDSTRL------TQAEISEQPTMATVVP------QVPTSPKSSL 1159
Query: 714 QIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDEL 754
++ + + T R S R S +P ++D++
Sbjct: 1160 SVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDM 1200
Score = 33.5 bits (75), Expect = 1.2
Identities = 42/165 (25%), Positives = 56/165 (33%), Gaps = 38/165 (23%)
Query: 615 TPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRR 674
+P P+ V+ + PS P P PP PP P PP PS
Sbjct: 610 SPQPKIVTPYTASQPSPPLPPPPPPPPPPP------------PPPPPPPPPLPSQ----- 652
Query: 675 VYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLR 734
APS S P+ + + + S+ + P ++P L
Sbjct: 653 --SAPS-------AGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQIL- 702
Query: 735 EPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPS 779
PP +PPPP P P MAQL+ P P APS
Sbjct: 703 VPPNGVVPPPPPPPPP-----PTPGSAMAQLK------PAPCAPS 736
Score = 31.6 bits (70), Expect = 4.5
Identities = 20/65 (30%), Positives = 23/65 (35%), Gaps = 24/65 (36%)
Query: 720 PVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPS 779
P++P P + P Y P LPPPP P P PPP P
Sbjct: 608 PLSPQPKIVTP-YTASQPSPPLPPPPPPPP-----------------------PPPPPPP 643
Query: 780 PTLPP 784
P PP
Sbjct: 644 PPPPP 648
>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 62.0 bits (149), Expect = 3e-09
Identities = 70/265 (26%), Positives = 94/265 (35%), Gaps = 33/265 (12%)
Query: 531 SAPGSPPDLLESVPKSISALPVNPHSIP-PRGPADLPPMPVTKPLQMVPRGSQLYPA--Q 587
S P S P + S P+ I + P N S P P GP P P P RG+ L +
Sbjct: 178 SKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPG-NRGTALGGGSIR 236
Query: 588 QTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPA--------PPYL 639
Q+ + P PP P P + PPP PPP P+ PP
Sbjct: 237 QSPLSSSSPFSNRPPLPPTPSRALDDKPPPP--------PPPVGNRPSIHREAVPPPPPQ 288
Query: 640 DHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPA 699
++ PP ++ P PP P G P S +E R + + +
Sbjct: 289 NNKPPVPSTPRPSASSQAPPPPPPPSRP----GPPPLPPSSSGNDETPRLPQRNLSLSSS 344
Query: 700 AVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRK 759
P P P+ P P++ P +R+PP P PP P S + R
Sbjct: 345 TPPLPSPGRSG---------PLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRAL 395
Query: 760 EIMAQLEERKVISPPPFAPSPTLPP 784
QL R + P P P LPP
Sbjct: 396 PATPQLPSRSGVDSPRSGPRPPLPP 420
Score = 40.0 bits (92), Expect = 0.013
Identities = 56/203 (27%), Positives = 67/203 (33%), Gaps = 36/203 (17%)
Query: 486 PSRK-PPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSP-PDLLESV 543
PSR PP LP S+GN T +P+ + LSSS P P P +
Sbjct: 313 PSRPGPPPLPPS--SSGNDETPRLPQ-------------RNLSLSSSTPPLPSPGRSGPL 357
Query: 544 PKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPR-GAAPP 602
P S P P PP LPP P R P + PR G PP
Sbjct: 358 PPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPP 417
Query: 603 FEPAPYQQGMYYTPPP---------------QCVSRFVRPPPSAPEPAPPYLD---HYPP 644
P G PPP + SRF P S P PY+ YP
Sbjct: 418 LPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPS 477
Query: 645 YLQERVVNSQYGTQPQQYPPIYP 667
L S + + PP+ P
Sbjct: 478 KLARNESRSGSNRRERGAPPLPP 500
Score = 38.1 bits (87), Expect = 0.048
Identities = 38/154 (24%), Positives = 52/154 (33%), Gaps = 21/154 (13%)
Query: 652 NSQYGTQPQQYPP---------IYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVP 702
N G++P PP P GR P+P + P E +P
Sbjct: 119 NDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSG--------PPEPQRNRMP 170
Query: 703 SYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIM 762
P+ + I P P P Q P PP P P P P+ R +
Sbjct: 171 PPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTAL 230
Query: 763 --AQLEERKVISPPPFAPSPTLPPTFHPEEFLDE 794
+ + + S PF+ P LPPT P LD+
Sbjct: 231 GGGSIRQSPLSSSSPFSNRPPLPPT--PSRALDD 262
>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 62.0 bits (149), Expect = 3e-09
Identities = 70/265 (26%), Positives = 94/265 (35%), Gaps = 33/265 (12%)
Query: 531 SAPGSPPDLLESVPKSISALPVNPHSIP-PRGPADLPPMPVTKPLQMVPRGSQLYPA--Q 587
S P S P + S P+ I + P N S P P GP P P P RG+ L +
Sbjct: 178 SKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPG-NRGTALGGGSIR 236
Query: 588 QTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPA--------PPYL 639
Q+ + P PP P P + PPP PPP P+ PP
Sbjct: 237 QSPLSSSSPFSNRPPLPPTPSRALDDKPPPP--------PPPVGNRPSIHREAVPPPPPQ 288
Query: 640 DHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPA 699
++ PP ++ P PP P G P S +E R + + +
Sbjct: 289 NNKPPVPSTPRPSASSQAPPPPPPPSRP----GPPPLPPSSSGNDETPRLPQRNLSLSSS 344
Query: 700 AVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRK 759
P P P+ P P++ P +R+PP P PP P S + R
Sbjct: 345 TPPLPSPGRSG---------PLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRAL 395
Query: 760 EIMAQLEERKVISPPPFAPSPTLPP 784
QL R + P P P LPP
Sbjct: 396 PATPQLPSRSGVDSPRSGPRPPLPP 420
Score = 40.0 bits (92), Expect = 0.013
Identities = 56/203 (27%), Positives = 67/203 (33%), Gaps = 36/203 (17%)
Query: 486 PSRK-PPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSP-PDLLESV 543
PSR PP LP S+GN T +P+ + LSSS P P P +
Sbjct: 313 PSRPGPPPLPPS--SSGNDETPRLPQ-------------RNLSLSSSTPPLPSPGRSGPL 357
Query: 544 PKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPR-GAAPP 602
P S P P PP LPP P R P + PR G PP
Sbjct: 358 PPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPP 417
Query: 603 FEPAPYQQGMYYTPPP---------------QCVSRFVRPPPSAPEPAPPYLD---HYPP 644
P G PPP + SRF P S P PY+ YP
Sbjct: 418 LPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPS 477
Query: 645 YLQERVVNSQYGTQPQQYPPIYP 667
L S + + PP+ P
Sbjct: 478 KLARNESRSGSNRRERGAPPLPP 500
Score = 38.1 bits (87), Expect = 0.048
Identities = 38/154 (24%), Positives = 52/154 (33%), Gaps = 21/154 (13%)
Query: 652 NSQYGTQPQQYPP---------IYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVP 702
N G++P PP P GR P+P + P E +P
Sbjct: 119 NDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSG--------PPEPQRNRMP 170
Query: 703 SYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIM 762
P+ + I P P P Q P PP P P P P+ R +
Sbjct: 171 PPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTAL 230
Query: 763 --AQLEERKVISPPPFAPSPTLPPTFHPEEFLDE 794
+ + + S PF+ P LPPT P LD+
Sbjct: 231 GGGSIRQSPLSSSSPFSNRPPLPPT--PSRALDD 262
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 61.6 bits (148), Expect = 4e-09
Identities = 74/297 (24%), Positives = 100/297 (33%), Gaps = 56/297 (18%)
Query: 514 PSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNP-----HSIPPRGPADLPPM 568
P +S L P +P SPP + LP +P H P + L P
Sbjct: 443 PPEESPLSPPP-----EESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPP 497
Query: 569 PVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAP----PFEPAPYQQGMYYTPPPQCVSRF 624
P PL P S P +++ + + +P P P P + PP S
Sbjct: 498 PEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPL---SPPFEESPL 554
Query: 625 VRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTRE 684
PP P PP P +E ++ P PP + R++P
Sbjct: 555 SPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPP------EASRLFPP------ 602
Query: 685 EIFRESPI-------PIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPP 737
F ESP+ P+ PP A P P++P P R S L P
Sbjct: 603 --FEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPL--PV 658
Query: 738 YSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPP----FAPSPTLPPTFHPEE 790
SRL PPP+ P ++ E SPPP +P P PT P E
Sbjct: 659 VSRLSPPPEESP------------LSPPPEESPTSPPPEASRLSPPPEDSPTSPPPE 703
Score = 54.7 bits (130), Expect = 5e-07
Identities = 87/354 (24%), Positives = 120/354 (33%), Gaps = 48/354 (13%)
Query: 458 PLSASLGQLNEVGLPSAAIL---PDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDP 514
PLS +L P A+ L P+E + P + P P S + P P
Sbjct: 553 PLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPP 612
Query: 515 SYDSSLKPGKIDHLS---SSAPGSPPDLLESVPKS-------ISALPVNPHSIPPRGPAD 564
P + LS +P SPP E P S +S LPV PP +
Sbjct: 613 EESPLSPPPEASRLSPPPEDSPMSPPP--EESPMSPPPEVSRLSPLPVVSRLSPPPEESP 670
Query: 565 LPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRG--AAPPFEPA----PYQQGMYYTPP- 617
L P P P P S+L P + P A+PP E + P ++ P
Sbjct: 671 LSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPE 730
Query: 618 -PQCVSRFVRPPPSAPEPAPPYLDHYP--PYLQERVVNSQYGTQPQQ-------YPPIYP 667
PQ R P +P P P+L P P+L + QP++ P
Sbjct: 731 EPQLCPR-SEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLS 789
Query: 668 SHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP-VAPHPT 726
+G + P P E P +P P P+ E + +S P ++P P
Sbjct: 790 PQAEGPHLSPQPEELHLSPQTEEPHLSPVPEE--PCLSPQPEESHLSPQSEEPCLSPRPE 847
Query: 727 QIRPS-YLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPS 779
+ S L +PP S P P P E + PPP PS
Sbjct: 848 ESHLSPELEKPPLSPRPEKPPEEPG-----------QCPAPEELPLFPPPGEPS 890
Score = 51.6 bits (122), Expect = 4e-06
Identities = 77/303 (25%), Positives = 114/303 (37%), Gaps = 56/303 (18%)
Query: 527 HLSSSAPGSPPDL-LESVPKSISALPVNPHS----------IPPRGPADLPPMPVTKPLQ 575
H++S P P L E+ P + + + P +PP + L P P P
Sbjct: 400 HVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTS 459
Query: 576 MVPRGSQLYPAQQ-------TDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQC--VSRFVR 626
P S+L P + + + P P P + + +PPP+ S
Sbjct: 460 PPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPL--SPPPESSPFSPLEE 517
Query: 627 PPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYP---APSYTR 683
P S PE +PP P L+ + + P + P+ P + P P+
Sbjct: 518 SPLSPPEESPP-----SPALETPL------SPPPEASPLSPPFEESPLSPPPEELPTSPP 566
Query: 684 EEIFRESPIPIEIPPAAVP-----SYVPESRERYQQIESYYPVAPHPTQIRPSYLREPP- 737
E R SP P E P + P S PE+ + E P++P P + S L PP
Sbjct: 567 PEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEE-SPLSPPPEE---SPLSPPPE 622
Query: 738 YSRLPPPPQPHPSL---DELHRRRKEIMAQLEERKVI---SPP----PFAPSPTLPPTFH 787
SRL PPP+ P +E +++L V+ SPP P +P P PT
Sbjct: 623 ASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSP 682
Query: 788 PEE 790
P E
Sbjct: 683 PPE 685
Score = 47.4 bits (111), Expect = 8e-05
Identities = 67/306 (21%), Positives = 102/306 (33%), Gaps = 40/306 (13%)
Query: 478 PDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLS---SSAPG 534
P+E + P P +VS + + P P + P + LS +P
Sbjct: 639 PEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPT 698
Query: 535 SPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQ 594
SPP P+ A P S+ + P +P+ + Q+ PR + + + + +
Sbjct: 699 SPP------PEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHL 752
Query: 595 DPRGAAPPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQ-----ER 649
PR P P + + P C+ P +P+ P+L P L E
Sbjct: 753 SPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEE 812
Query: 650 VVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIF---------------------R 688
S +P P SH + P S EE
Sbjct: 813 PHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPG 872
Query: 689 ESPIPIEI---PPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYS--RLPP 743
+ P P E+ PP PS P E P++P P ++ S EP S +PP
Sbjct: 873 QCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPP 932
Query: 744 PPQPHP 749
P P P
Sbjct: 933 DPLPPP 938
Score = 43.1 bits (100), Expect = 0.001
Identities = 94/391 (24%), Positives = 121/391 (30%), Gaps = 138/391 (35%)
Query: 476 ILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPG- 534
I P GA+ P P A P + + T P G S D LKP + S PG
Sbjct: 2106 IPPQPGALGSPP--PAAAPTIFIGSPTT-----PAGLSTSADGFLKPP-----AGSVPGP 2153
Query: 535 -SPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYY 593
SP +L +P + P +P + P L P +P P YP Y
Sbjct: 2154 DSPGELFLKLPPQV------PAQVPSQDPFGLAPAYPLEP--RFPTAPPTYPP------Y 2199
Query: 594 QDPRGAA--PPF-----EPAPYQQGMYYTPP----------------PQCVSR------- 623
P GA PP P Q G ++T P P+C S
Sbjct: 2200 PSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPE 2259
Query: 624 ------------FVRPPP-----------------SAPEPAPPYLDHY------------ 642
+ PPP S+P PP L
Sbjct: 2260 SPGVGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGL 2319
Query: 643 -------------PPYLQERVVNSQYGTQPQQYPPIY------PSHYDGRRV--YPAPSY 681
P Q + G +PQ+ PP PSH D R Y P
Sbjct: 2320 ELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYA 2379
Query: 682 TREEIFRESPIPIE----IPPAAVPS----YVPESRERYQQIESYYPVAPHP-------- 725
R P P E +PP ++PS VP S + Q S P+ P P
Sbjct: 2380 QPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQ--SQSSSQSPLTPRPLSAEAFCP 2437
Query: 726 TQIRPSYLREPPYSRLPPPPQPHPSLDELHR 756
+ + P + PYSR P PQ LH+
Sbjct: 2438 SPVTPRFQSPDPYSRPPSRPQSRDPFAPLHK 2468
Score = 42.7 bits (99), Expect = 0.002
Identities = 67/261 (25%), Positives = 96/261 (36%), Gaps = 52/261 (19%)
Query: 514 PSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKP 573
P + SL P + + S PG PP L +P+ LP++P P P +PP P+ P
Sbjct: 885 PPGEPSLSP-LLGEPALSEPGEPP--LSPLPEE---LPLSPSGEPSLSPQLMPPDPLPPP 938
Query: 574 LQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEP-APYQQGMYYTPPPQCVSRFVRPPPSA- 631
L + + PA + P GA +P +P + TP + PPP A
Sbjct: 939 LSPIITAA-APPALSPLGELEYPFGAKGDSDPESPLAAPILETP--------ISPPPEAN 989
Query: 632 ---PEPAPPYLDHYPPYLQERVVNSQYG-TQPQQYPPIYPSHYDGRRVYPAPSYTREEIF 687
PEP PP + PP S G P P+ P +P +
Sbjct: 990 CTDPEPVPPMI--LPP-----SPGSPVGPASPILMEPLPPQ--------CSPLLQHSLVP 1034
Query: 688 RESPIPIEIPPAAVPSYVP------------ESRERYQQIESYYPVAPHPTQIRPSY--- 732
+ SP P + P A+P VP ++E+ P + PS
Sbjct: 1035 QNSP-PSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSP 1093
Query: 733 LREPPYSRLPPPPQPHPSLDE 753
L P P P P P+LD+
Sbjct: 1094 LPSPMGDLSCPAPSPAPALDD 1114
Score = 39.7 bits (91), Expect = 0.016
Identities = 60/242 (24%), Positives = 80/242 (33%), Gaps = 38/242 (15%)
Query: 544 PKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPF 603
P +S + P S P PP P T P M QL Q +YQ R P
Sbjct: 2753 PSKLSGPILGPGSFPSDDRLSRPPPPAT-PSSMDVNSRQLVGGSQA--FYQ--RAPYPGS 2807
Query: 604 EPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYP 663
P QQ + + +R SA P+ P P L + + S + P
Sbjct: 2808 LPLQQQQQQLWQQQQATAATSMRFAMSARFPSTP-----GPELGRQALGSPLAGISTRLP 2862
Query: 664 PIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVP--SYVPESRERYQQIESYYPV 721
G V P P+ + I + + P P P R R+ YPV
Sbjct: 2863 G------PGEPV-PGPAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRF------YPV 2909
Query: 722 APHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSPT 781
+ P ++ P LR S LPP P EL+ + P P PT
Sbjct: 2910 SEDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNS-------------LHPTPHTKGPT 2956
Query: 782 LP 783
LP
Sbjct: 2957 LP 2958
Score = 34.3 bits (77), Expect = 0.69
Identities = 42/150 (28%), Positives = 57/150 (38%), Gaps = 16/150 (10%)
Query: 510 RGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMP 569
R +P +L P H PGS D P + P P S P LP P
Sbjct: 2348 RPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDP 2407
Query: 570 VTKPLQMVPRGSQLYPAQQTDVYYQDPRG-AAPPFEPAPYQQGMYYTPPPQCVSRFVRPP 628
++ VP Q + Q+ + PR +A F P+P TP Q + R P
Sbjct: 2408 FSR----VPASPQSQSSSQSPL---TPRPLSAEAFCPSP------VTPRFQSPDPYSR-P 2453
Query: 629 PSAPEPAPPYLD-HYPPYLQERVVNSQYGT 657
PS P+ P+ H PP Q V + G+
Sbjct: 2454 PSRPQSRDPFAPLHKPPRPQPPEVAFKAGS 2483
Score = 30.8 bits (68), Expect = 7.6
Identities = 36/131 (27%), Positives = 51/131 (38%), Gaps = 22/131 (16%)
Query: 458 PLSASLG---QLNEVGLPSAAILPDEGAVDLPSRKPPALPN--GIVSTGNTVTQLIPRGT 512
PL LG QL P L + GA P + PP LP G +STG + + P
Sbjct: 4252 PLQGLLGCQPQLGGFPGPQTGPLQELGAGPRP-QGPPRLPAPPGALSTGPVLGPVHPTPP 4310
Query: 513 DPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTK 572
S +P ++ SS +P P +P + P+GP PP
Sbjct: 4311 PSSPQEPKRPSQLPSPSSQ-----------LPTEAQLPPTHPGTPKPQGPTLEPP----- 4354
Query: 573 PLQMVPRGSQL 583
P ++ P +QL
Sbjct: 4355 PGRVSPAAAQL 4365
>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
sapiens]
Length = 1362
Score = 60.5 bits (145), Expect = 9e-09
Identities = 94/379 (24%), Positives = 129/379 (34%), Gaps = 81/379 (21%)
Query: 472 PSAAILPDEGAVDLPSRKPP-----------ALPNGIVSTGNTVTQLIPRGTDPSYDSSL 520
P +P + A + S PP LP + TQ I P L
Sbjct: 780 PPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHL 839
Query: 521 ----KPGKIDHLSSSAPGSPPDLLESVPKSIS-------ALPVNPHSIPPRGPAD----- 564
+ HL+ A SPP L ++P+ S ALP P P PA
Sbjct: 840 PQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPL 899
Query: 565 LPPMPVTKPLQMVPRGS------------QLYPAQQTDVYYQDP--------RGAAPPFE 604
LP P+ +P Q++ QLY Q V P PP
Sbjct: 900 LPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLP 959
Query: 605 PAPY---QQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQ 661
P P+ QQ + PPP PPP P+P PP H PP + Q+ T QQ
Sbjct: 960 PPPHPSVQQQLQQQPPP--------PPPPQPQP-PPQQQHQPPPRPVHLQPMQFSTHIQQ 1010
Query: 662 YPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAV--PSYVPESRERYQQIESYY 719
PP + +P P ++ P P P V + P + +
Sbjct: 1011 PPP----PQGQQPPHPPPG-------QQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHL 1059
Query: 720 PVAPHPTQIRPSYLREPPYSRLPPPPQPH--PSLDELHRR---RKEIMAQLEERKVISP- 773
AP P I + + PPQ + P EL + + + ++E K+ SP
Sbjct: 1060 REAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPI 1119
Query: 774 ---PPFAPSPTLPPTFHPE 789
PF+PS P HPE
Sbjct: 1120 IRSEPFSPSLRPEPPKHPE 1138
Score = 54.3 bits (129), Expect = 6e-07
Identities = 106/461 (22%), Positives = 164/461 (35%), Gaps = 109/461 (23%)
Query: 399 SKKGADQQQPPQHSKYKTYMCRDMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRP 458
+KK ++ PP+ +K ++ ++ P + + EE +K + M+ +R
Sbjct: 560 NKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYE--EKRQ 617
Query: 459 LSASLGQLNEVGLPSAAIL------------PDEGAVDLPSRKPPALPNGIVSTGNTVTQ 506
LS + +L L + PDE +D + KP L VT
Sbjct: 618 LSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRE----LERYVTS 673
Query: 507 LIPRGTDPSYD--------SSLKPGKIDHLSSSAPGSPPDLLES----VPKSISALPV-- 552
+ + P + S +K SS+ S D +S PKS
Sbjct: 674 CLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGR 733
Query: 553 -------NPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEP 605
+ H + PA +P P P Q P P QQ Q P PP P
Sbjct: 734 EQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPP----PPQQQQ---QPPPPPPPPSMP 786
Query: 606 APYQQGMYYTPPP------------------QCVSRFVRPPPSAPEP-APPYLDH----- 641
M +PPP + F +P P+P PP+L
Sbjct: 787 QQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHS 846
Query: 642 YPPYLQERVVNSQ---YGTQPQQYPPIYPSH-------YDGRRVYPAPSYTREEIFRESP 691
PP+L + V S + PQQ P PS+ R +P+ T+ + + P
Sbjct: 847 TPPHLNQHAVVSPPALHNALPQQ--PSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPP 904
Query: 692 I--PIEI-----PPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSY-LREPPYSRLPP 743
+ P ++ P A P + + QQ++ P PT + PS ++ P LPP
Sbjct: 905 MAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQP----PTPLLPSVKVQSQPPPPLPP 960
Query: 744 PPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSPTLPP 784
P PHPS+ + QL+++ PPP P P PP
Sbjct: 961 P--PHPSVQQ----------QLQQQ---PPPPPPPQPQPPP 986
Score = 38.5 bits (88), Expect = 0.037
Identities = 53/230 (23%), Positives = 82/230 (35%), Gaps = 61/230 (26%)
Query: 547 ISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPA 606
+S +P + P P P P P+Q P +PA D+ Q P P P
Sbjct: 193 VSTVPNTTQASTP--PQTQTPQPNPPPVQATPHP---FPAVTPDLIVQTPVMTVVP--PQ 245
Query: 607 PYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIY 666
P Q PPP P+P PP P Q +PPI
Sbjct: 246 PLQT----------------PPPVPPQPQPPPAPAPQPV--------------QSHPPII 275
Query: 667 PSHYDGRRVYPAPSYTREEIFRESPI-------PIEIPPAAVPSYVPESRERYQQIESYY 719
+ P P T++ + R++ PI PP+ P P++ + Q+ ES
Sbjct: 276 AA-------TPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPE--PKTTKLGQRRESSR 326
Query: 720 PVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERK 769
PV P ++ P S+ P P+ + E + I+ ++ +K
Sbjct: 327 PVKPPK--------KDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKK 368
Score = 31.6 bits (70), Expect = 4.5
Identities = 41/193 (21%), Positives = 64/193 (33%), Gaps = 32/193 (16%)
Query: 653 SQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRES------PIPIEIPPAAVPSYVP 706
+Q T PQ P +P P+ T + I + P P++ PP P P
Sbjct: 200 TQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQP 259
Query: 707 ESRERYQQIESYYPV---APHPTQIRPSYLREPPYS--------RLPPPPQPHPSLDELH 755
Q ++S+ P+ P P + + R+ + PP P P +L
Sbjct: 260 PPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLG 319
Query: 756 RRRKEIMAQLEERKVISPPPFAPSPTLPPTFHPEEFLDEDLK---------VAGKYKGND 806
+RR+ R V P P P + E LK A K+
Sbjct: 320 QRRE------SSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYA 373
Query: 807 YSQYSPWSCDTIG 819
+ Y P + +G
Sbjct: 374 WPFYKPVDVEALG 386
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
Length = 816
Score = 59.3 bits (142), Expect = 2e-08
Identities = 87/343 (25%), Positives = 118/343 (34%), Gaps = 42/343 (12%)
Query: 455 PRRPLSASLGQLNEVGLPSAAILPDEGAVDLPSRKPP--ALPNGIVSTGNTVTQLIPRGT 512
PR+ + +LG L+ L + P A PS P LP+ + + T + T
Sbjct: 279 PRKDAAPALGPLSSSPLAT----PSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPT 334
Query: 513 DPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTK 572
+ S L + L++ P +PP L ALP P PP PA P P+
Sbjct: 335 LQATHSFLPSPPLSPLATPPPQAPPAL---------ALP--PLQAPPSPPASPPLSPLAT 383
Query: 573 PLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAP 632
P P ++ Q P AP PA TPP Q PP P
Sbjct: 384 PSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVP 443
Query: 633 EPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRESPI 692
P+PP PP S T P Q PP P ++ P +
Sbjct: 444 -PSPP---ASPPM-------SPSATPPPQAPP--PLAAPPLQLAKPPPQAPPALATPPLQ 490
Query: 693 PIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLD 752
+ PPA+ P P S + P+A P Q P + P ++PP P P+L
Sbjct: 491 ALPSPPASFPGQAPFSPSASLPMS---PLATPPPQAPP--VLAAPLLQVPPSPPASPTLQ 545
Query: 753 ELHRRRKEIMAQLEERKVISPP---PFAPSPTLPPTFHPEEFL 792
R + V P AP P PP+ P L
Sbjct: 546 APRRP----PTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTL 584
Score = 55.8 bits (133), Expect = 2e-07
Identities = 95/364 (26%), Positives = 116/364 (31%), Gaps = 76/364 (20%)
Query: 468 EVGLPSAAILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDH 527
EVGLP P A P + P S +T PS L+
Sbjct: 177 EVGLPR----PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 232
Query: 528 LSSSA-PGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKP------------- 573
LSSSA P S P + P +P P+G L P VT P
Sbjct: 233 LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 292
Query: 574 -------------------LQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYY 614
LQ +P P+Q T A F P+P +
Sbjct: 293 SPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPL-A 351
Query: 615 TPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRR 674
TPPPQ PP AP P+PP PP S T Q P H
Sbjct: 352 TPPPQAPPALALPPLQAP-PSPP---ASPPL-------SPLATPSPQAPNALAVHLLQAP 400
Query: 675 VYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLR 734
P PS + F P P A PS P S +A P Q+ PS
Sbjct: 401 FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPS------------LAAPPLQVPPSPPA 448
Query: 735 EPPY--SRLPPPPQPHP------SLDELHRRRKEIMAQLEERKVISPP-------PFAPS 779
PP S PPP P P L + + +A + + SPP PF+PS
Sbjct: 449 SPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 508
Query: 780 PTLP 783
+LP
Sbjct: 509 ASLP 512
>gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]
Length = 464
Score = 57.8 bits (138), Expect = 6e-08
Identities = 69/244 (28%), Positives = 89/244 (36%), Gaps = 32/244 (13%)
Query: 531 SAPGSPPDLLESVPKSISALPVNP---HSIPPRGPA--DLPPMPVTKPLQMVPRGSQLYP 585
S P PP + P ++ LP P S+PP P LPPMP T P P G P
Sbjct: 222 SLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLP 281
Query: 586 AQQTDVYYQDP------RGAAPP----FEPAP--YQQGMYYTPPPQCV---SRFVRPP-- 628
V+ P G PP PAP + PP V + V PP
Sbjct: 282 PPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAP 341
Query: 629 ---PSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPS----HYDGRRVYPAPSY 681
P AP PP +PP S G PQ P ++P+ H V+P
Sbjct: 342 GVHPPAPGVHPPAPGVHPPAPGVHPPPSA-GVHPQA-PGVHPAAPAVHPQAPGVHPPAPG 399
Query: 682 TREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRL 741
+ P P + P+A P P+ + +P P P +RP E P +
Sbjct: 400 MHPQAPGVHPQPPGVHPSA-PGVHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIP 458
Query: 742 PPPP 745
PPPP
Sbjct: 459 PPPP 462
>gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]
Length = 639
Score = 57.4 bits (137), Expect = 8e-08
Identities = 89/370 (24%), Positives = 122/370 (32%), Gaps = 59/370 (15%)
Query: 424 QRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDEGAV 483
QR G P+ A +E L ++ + VP AS+G + A P A
Sbjct: 295 QRPGDPQSAQDKARMDKEYLSLMAELGEAPVP-----ASVGSTSGPATTPLASAPRPAA- 348
Query: 484 DLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDH-LSSSAPGSPPDLLES 542
P+ PP P ++ST TQ P P +S + H + PG P S
Sbjct: 349 --PANNPP--PPSLMST----TQSRP----PWMNSGPSESRPYHGMHGGGPGGPGGGPHS 396
Query: 543 VPKSISALPV----NPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRG 598
P + +L +P P GP P P+ P + D Y
Sbjct: 397 FPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYL----- 451
Query: 599 AAPPFEPAPYQ--QGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYG 656
+ P Y+ QG PPP PPP + +P PP PP+ Q
Sbjct: 452 GSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQ--------- 502
Query: 657 TQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIE 716
Q QQ PP P P P S IPP + Q++
Sbjct: 503 -QQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQ 561
Query: 717 SYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPF 776
+ P P ++P PP + PPPP P S ++ +PPP
Sbjct: 562 GNPTMVPLPPGVQPPL---PPGAPPPPPPPPPGSAGMMY----------------APPPP 602
Query: 777 APSPTLPPTF 786
P P P F
Sbjct: 603 PPPPMDPSNF 612
>gi|18959210 WIRE protein [Homo sapiens]
Length = 440
Score = 57.4 bits (137), Expect = 8e-08
Identities = 84/342 (24%), Positives = 123/342 (35%), Gaps = 70/342 (20%)
Query: 450 NKRLVPRRPLSASLGQLNEVGLPSAAILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIP 509
++ PR P+SA+ G+ + S A LP+ + PS + PN STG + P
Sbjct: 118 SRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAP 177
Query: 510 RGTDPSYDSSLKPGKIDHLSSSAPG------SPPDLLESVPKSISALPVNPHSIPPRGPA 563
P ++ P + SS AP PP + + P P PP P
Sbjct: 178 PPPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPV 237
Query: 564 DL----------PPMPVTKPLQMVPRG--------SQLYPAQQTDVYYQDP---RGAAPP 602
++ PP P + VP G + P + ++ + P RG APP
Sbjct: 238 NIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTNESAPELPQRHNSLHRKTPGPVRGLAPP 297
Query: 603 FEPAPYQQGMYYTPPPQC---VSRFVRPPP----------SAPEPAPPYLDH-------- 641
+ + PPP SR PPP AP P PPY H
Sbjct: 298 PPTSASPSLLSNRPPPPARDPPSRGAAPPPPPPVIRNGARDAPPPPPPYRMHGSEPPSRG 357
Query: 642 YPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAV 701
PP R + G P PP+ H D + S+ + + S P+E PA
Sbjct: 358 KPPPPPSR---TPAGPPPPPPPPLRNGHRDS--ITTVRSFLDDFESKYSFHPVEDFPA-- 410
Query: 702 PSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPP 743
PE + +Q+I +P++ + PP LPP
Sbjct: 411 ----PEEYKHFQRI--------YPSKTNRAARGAPP---LPP 437
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 855
Score = 57.0 bits (136), Expect = 1e-07
Identities = 93/370 (25%), Positives = 122/370 (32%), Gaps = 66/370 (17%)
Query: 455 PRRPLSASLGQLNEVGL----PSAAILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPR 510
PR+ + +LG L+ L PSAA L S+ PP LP S+ T P
Sbjct: 288 PRKDAAPALGPLSSSPLATPSPSAA---------LQSQAPPTLPATPHSSSLTCQLATPL 338
Query: 511 GTDPSYDSSLKPGKIDHLSSSAPGSPPD-------------------------LLESVPK 545
P S+ P + L S P +PP L P+
Sbjct: 339 PLAPPSPSA--PPSLQTLPSP-PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQ 395
Query: 546 SISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEP 605
+ AL + P PP PA P P+ P P ++ Q P AP P
Sbjct: 396 APPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPP 455
Query: 606 APYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPI 665
A TPP Q PP P P+PP PP S T P Q PP
Sbjct: 456 ASPPVSPSATPPSQAPPSLAAPPLQVP-PSPP---ASPPM-------SPSATPPPQAPP- 503
Query: 666 YPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHP 725
P ++ P + + PPA+ P P S + P+A P
Sbjct: 504 -PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMS---PLATPP 559
Query: 726 TQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPP---PFAPSPTL 782
Q P + P ++PP P P+L R + V P AP P
Sbjct: 560 PQAPP--VLAAPLLQVPPSPPASPTLQAPRRP----PTPGPDTSVSGPRLTLALAPGPPP 613
Query: 783 PPTFHPEEFL 792
PP+ P L
Sbjct: 614 PPSRSPSSTL 623
Score = 47.0 bits (110), Expect = 1e-04
Identities = 97/394 (24%), Positives = 118/394 (29%), Gaps = 106/394 (26%)
Query: 468 EVGLPSAAILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDH 527
EVGLP P A P + P S +T PS L+
Sbjct: 186 EVGLPR----PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241
Query: 528 LSSSA-PGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKP------------- 573
LSSSA P S P + P +P P+G L P VT P
Sbjct: 242 LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 301
Query: 574 -------------------LQMVPRGSQLYPAQQTDVYYQDPRGAAPP------------ 602
L P S L T + P +APP
Sbjct: 302 SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATP 361
Query: 603 ------------------FEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPP 644
F P+P + TPPPQ PP AP P+PP PP
Sbjct: 362 PSQATTSLGSPTLQATHSFLPSPPLSPL-ATPPPQAPPALALPPLQAP-PSPP---ASPP 416
Query: 645 YLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSY 704
S T Q P H P PS + F P P A PS
Sbjct: 417 L-------SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQ 469
Query: 705 VPESRERYQQIESYYPVAPHPTQIRPSYLREPPY--SRLPPPPQPHP------SLDELHR 756
P S +A P Q+ PS PP S PPP P P L +
Sbjct: 470 APPS------------LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPP 517
Query: 757 RRKEIMAQLEERKVISPP-------PFAPSPTLP 783
+ +A + + SPP PF+PS +LP
Sbjct: 518 QAPPALATPPLQALPSPPASFPGQAPFSPSASLP 551
>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
sapiens]
Length = 1560
Score = 56.6 bits (135), Expect = 1e-07
Identities = 103/422 (24%), Positives = 138/422 (32%), Gaps = 89/422 (21%)
Query: 363 IDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQ---HSKYKTYMC 419
+ P+P APP L GL + Q + A QP S K +
Sbjct: 621 VQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEKIVL- 679
Query: 420 RDMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPD 479
G P A+ T +Q+ L+ F + ++PLSA L+ +P++ I+
Sbjct: 680 -------GQPPSATPTAILTQDSLQMFLPQERS---QQPLSAEGPHLS---VPASVIVSA 726
Query: 480 EGAVDLPSRKPPALPNGIVSTGNTVTQLIP------------RGTDPSYDSSLKP----G 523
P+ P + +Q P +G PS SL G
Sbjct: 727 PPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLG 786
Query: 524 KIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQL 583
HL S P PP S P+S+S P S PP P P P T P V
Sbjct: 787 DSPHLPSPHPTRPPSRPPSRPQSVS----RPPSEPPLHPCPPPQAPPTLPGIFV------ 836
Query: 584 YPAQQTDVYYQDPRGAAPP-FEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHY 642
Q+ G PP PAP G PPQ R PP P P P H
Sbjct: 837 ---------IQNQLGVPPPASNPAPTAPG-----PPQPPLRPQSQPPEGPLPPAP---HL 879
Query: 643 PPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVP 702
PP V S T + PAP+ S ++ PP+ P
Sbjct: 880 PPSSTSSAVASSSETSSR---------------LPAPT--------PSDFQLQFPPSQGP 916
Query: 703 SYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIM 762
P + P AP P R + P+ P PQP L+ H+ I+
Sbjct: 917 HKSPTPPPTLHLVPE--PAAPPPPPPRTFQMVTTPF---PALPQPKALLERFHQVPSGII 971
Query: 763 AQ 764
Q
Sbjct: 972 LQ 973
Score = 35.0 bits (79), Expect = 0.40
Identities = 19/54 (35%), Positives = 23/54 (42%), Gaps = 9/54 (16%)
Query: 612 MYYTPPPQCVSRFVRPPPSAPEPAPP------YLDHYPPYLQERVVNSQYGTQP 659
++ PPP + PPP P P PP +DH PP ER GT P
Sbjct: 1330 VHQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPER---KPLGTAP 1380
Score = 34.3 bits (77), Expect = 0.69
Identities = 45/185 (24%), Positives = 64/185 (34%), Gaps = 31/185 (16%)
Query: 459 LSASLGQLNEVGLPSAAILPDEGAVDLPSRKPPALP---NGIVSTGNTVTQLIPRGTDPS 515
L+++ G V L SA + P + + A+ NG G P GT
Sbjct: 263 LASAAGPSEPVTLASAGVSPQGAGLVIQKNLSAAVATTLNGNSVFGGAGAASAPTGTPSG 322
Query: 516 YDSSLKPGKIDHLSSSAPGS-----------------PPDLLESVPKSIS------ALPV 552
++ PG AP PP L + PK + +
Sbjct: 323 QPLAVAPGLGSSPLVPAPNVILHRTPTPIQPKPAGVLPPKLYQLTPKPFAPAGATLTIQG 382
Query: 553 NPHSIP--PRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDP---RGAAPPFEPAP 607
P ++P P+ P +L M K Q V PA Q +V+ Q P GAAPP P
Sbjct: 383 EPGALPQQPKAPQNLTFMAAGKAGQNVVLSGFPAPALQANVFKQPPATTTGAAPPQPPGA 442
Query: 608 YQQGM 612
+ M
Sbjct: 443 LSKPM 447
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 56.2 bits (134), Expect = 2e-07
Identities = 83/371 (22%), Positives = 132/371 (35%), Gaps = 44/371 (11%)
Query: 445 KFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDEGAVDLPSRKPPALPNGIVSTGNTV 504
K ++ K VP + + ++ E P P E +P +K PA P
Sbjct: 10552 KVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEV---VPEKKVPAAPPKKPEVTPVK 10608
Query: 505 TQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPAD 564
P+ P + P K P PP + VPK P +IPP+ P
Sbjct: 10609 VPEAPKEVVPEKKVPVPPPK-------KPEVPPTKVPEVPKVAVPEKKVPEAIPPK-PES 10660
Query: 565 LPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVSRF 624
PP +P ++ PA+ + +P AAPP P ++ + P V++
Sbjct: 10661 PPPEVFEEPEEVALEEP---PAEVVE----EPEPAAPPQVTVPPKKPVPEKKAPAVVAKK 10713
Query: 625 VRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVY-------- 676
PP P + P VV + P + P + ++V
Sbjct: 10714 PELPPVKVPEVPK--EVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVP 10771
Query: 677 PA--PSYTREEIFRESP-IPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYL 733
PA P ++ + E P +P+ P S PE E ++I +AP + P
Sbjct: 10772 PAKVPEVPKKPVLEEKPAVPV---PERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAE 10828
Query: 734 REPPYSRLPPPPQPHPSLDELHRRRKEIM--------AQLEERKVISPPPFAPSPTLPPT 785
E P +PPP P + ++ ++ + E KVI P P P PP
Sbjct: 10829 EEEP--EVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPP 10886
Query: 786 FHPEEFLDEDL 796
P+E + E +
Sbjct: 10887 APPKEDVKEKI 10897
Score = 55.1 bits (131), Expect = 4e-07
Identities = 79/378 (20%), Positives = 140/378 (37%), Gaps = 91/378 (24%)
Query: 468 EVGLPSAAILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDH 527
+V +P +P++ A + ++KP P V +++P K+
Sbjct: 10692 QVTVPPKKPVPEKKAPAVVAKKPELPP---VKVPEVPKEVVPEK------------KVPL 10736
Query: 528 LSSSAPGSPPDLLESVPKSIS-----ALPVNPHSIPPRGPADLPPMPVT--KPLQMVPRG 580
+ P +PP + VPK + A+P P +PP ++P PV KP VP
Sbjct: 10737 VVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPE-VPPAKVPEVPKKPVLEEKPAVPVPER 10795
Query: 581 SQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVSRFVR-PPPSAPEP----- 634
++ P + Y++P AP E AP ++ P P PPP+ PE
Sbjct: 10796 AESPPPE----VYEEPEEIAPEEEIAPEEE----KPVPVAEEEEPEVPPPAVPEEPKKII 10847
Query: 635 ------------APPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYT 682
APP + P + E+ + +P PP P +++ +
Sbjct: 10848 PEKKVPVIKKPEAPPPKEPEPEKVIEK---PKLKPRPPPPPPAPPKEDVKEKIFQLKAIP 10904
Query: 683 REEIFRESPIP--IEIPPAAVPS-------YVPESRERYQQ---IESYYPVAPHPTQ--I 728
++++ + +P +E+ P VP +PE + ++ ++S P + +
Sbjct: 10905 KKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKV 10964
Query: 729 RPSYLREPPYSRLPPPPQPHP----SLDELHRRRKEIMAQLE------------------ 766
P L + +P PP P P + + +R ++I +
Sbjct: 10965 EPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPK 11024
Query: 767 ---ERKVISPPPFAPSPT 781
E K I PPP P PT
Sbjct: 11025 PEAEVKTIKPPPVEPEPT 11042
Score = 53.9 bits (128), Expect = 8e-07
Identities = 77/340 (22%), Positives = 125/340 (36%), Gaps = 39/340 (11%)
Query: 471 LPSAAILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSS 530
LP ++P++ P++KP A P + P+ P + P K
Sbjct: 10499 LPPKEVVPEKKVPVPPAKKPEAPPPKVPEA--------PKEVVPEKKVPVPPPK------ 10544
Query: 531 SAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVP-RGSQLYPAQQT 589
P PP + VPK+ P +IPP+ P PP P ++VP + P ++
Sbjct: 10545 -KPEVPPTKVPEVPKAAVPEKKVPEAIPPK-PESPPPEVPEAPKEVVPEKKVPAAPPKKP 10602
Query: 590 DV----YYQDPRGAAPPFE---PAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHY 642
+V + P+ P + P P + + T P+ V + P PE PP +
Sbjct: 10603 EVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPE-VPKVAVPEKKVPEAIPPKPESP 10661
Query: 643 PPYLQERVVNSQYGTQP----QQYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPP 698
PP + E P ++ P P P P + + P E+PP
Sbjct: 10662 PPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKP---ELPP 10718
Query: 699 AAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRR 758
VP VP+ +++ P P + P+ + E P +P P E+ +
Sbjct: 10719 VKVPE-VPKEVVPEKKVPLVVPKKP---EAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAK 10774
Query: 759 KEIMAQ---LEERKVISPPPFAPSPTLPPTFHPEEFLDED 795
+ + LEE+ + P A SP PEE E+
Sbjct: 10775 VPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEE 10814
Score = 48.5 bits (114), Expect = 4e-05
Identities = 77/356 (21%), Positives = 130/356 (36%), Gaps = 41/356 (11%)
Query: 451 KRLVPRRPLSAS---LGQLNEVGLPSAA--ILPDEGAVDLPSRKPPALPNGIVSTGNTVT 505
K +VP + + A+ ++ V +P A ++P++ P +KP P +
Sbjct: 10586 KEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAV 10645
Query: 506 --QLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPA 563
+ +P P +S P + A PP + P+ + V ++PP+
Sbjct: 10646 PEKKVPEAIPPKPESP-PPEVFEEPEEVALEEPPAEVVEEPEPAAPPQV---TVPPK--- 10698
Query: 564 DLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQD-PRGAAPPFEPAPYQQGMYYTP--PPQC 620
P+P K +V + +L P + +V + P P P + P P +
Sbjct: 10699 --KPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEV 10756
Query: 621 VSRFVRPPPSAPEPAPPYLDHYP--PYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPA 678
V P PE P + P P L+E+ P +Y + + P
Sbjct: 10757 VPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYE---EPEEIAPE 10813
Query: 679 PSYTREEIFRESPIPI------EIPPAAVPS----YVPESRERYQQIESYYPVAPHPTQI 728
EE E P+P+ E+PP AVP +PE + + P AP P +
Sbjct: 10814 EEIAPEE---EKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIK----KPEAPPPKEP 10866
Query: 729 RPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSPTLPP 784
P + E P + PPP P E + + + + ++KV P L P
Sbjct: 10867 EPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTP 10922
Score = 38.9 bits (89), Expect = 0.028
Identities = 71/333 (21%), Positives = 124/333 (37%), Gaps = 36/333 (10%)
Query: 454 VPRRPLSASLGQLNEVGLPSAAILPDEGAVDLPSRKPPA-LPNGIVSTGNTVTQLIPRGT 512
VP++P + + P A +P+ +P K P +P + + V ++ +
Sbjct: 9981 VPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPV 10040
Query: 513 DPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTK 572
P K++ +PP + VPK + P +P + + PP V K
Sbjct: 10041 PEKKVPVPAPKKVE--------APPAKVPEVPKKLIPEEKKPTPVPKK--VEAPPPKVPK 10090
Query: 573 PLQMVPRGSQLYPAQQTDVYYQD---PRGAAPPFEPAPYQQGMYYTPPPQCVSRFVRPPP 629
+ VP L Q+ +V +++ P P E + P + V P
Sbjct: 10091 KREPVPVPVAL--PQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIP 10148
Query: 630 SAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRE 689
E PP + Y P +E V + + + P+ P+ P P ++ ++
Sbjct: 10149 PEEEEVPPE-EEYVPEEEEFVPEEEVLPEVKPKVPV-PA--------PVPEIKKKVTEKK 10198
Query: 690 SPIP--IEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQP 747
IP E PPA VP + E+ + V P P E P S P +P
Sbjct: 10199 VVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEP---EEEPISEEEIPEEP 10255
Query: 748 HPSLDELHRRRKEIMAQLEERKVISPPPFAPSP 780
PS++E+ + ++ ++ V P AP+P
Sbjct: 10256 -PSIEEVEEVAPPRVPEVIKKAV----PEAPTP 10283
Score = 38.5 bits (88), Expect = 0.037
Identities = 52/242 (21%), Positives = 78/242 (32%), Gaps = 44/242 (18%)
Query: 587 QQTDVYYQDPRGAAP----PFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHY 642
++ + Y +P P P EP P + PP V + P P P P L
Sbjct: 9780 EEHEEYITEPEKPIPVKPVPEEPVPTKP----KAPPAKVLKKAVPEEKVPVPIPKKLKPP 9835
Query: 643 PPYLQERVV--------------NSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFR 688
PP + E + T+P P+ P P P R
Sbjct: 9836 PPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVR 9895
Query: 689 ESPIPIEIPP----------AAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPY 738
+P E+ P V Y+ E E Y E + + P + E P
Sbjct: 9896 VPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPR 9955
Query: 739 SRLPPPPQPHP----------SLDELHRRRKEIMAQLEERKVISPPPFAPSPTLPPTFHP 788
+P +P P + E+ ++ +E + L +K PP A P +P P
Sbjct: 9956 KPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKK--EKPPPAKVPEVPKKPVP 10013
Query: 789 EE 790
EE
Sbjct: 10014 EE 10015
Score = 38.1 bits (87), Expect = 0.048
Identities = 41/211 (19%), Positives = 81/211 (38%), Gaps = 28/211 (13%)
Query: 533 PGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVY 592
P P++ + V + +P + P + P P V + ++P+ ++ P + T+
Sbjct: 10184 PAPVPEIKKKVTEKKVVIPKKEEAPPAKVPE--VPKKVEEKRIILPKEEEVLPVEVTEEP 10241
Query: 593 YQDPRGAAPPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERV-- 650
++P E P + + PP+ + P AP P P ++ P + +++
Sbjct: 10242 EEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPE 10301
Query: 651 ----VNSQYGTQPQQYPPIYPSHYDGRRVY--------PAPSYT----------REEIFR 688
V Q P P P ++V PA T R+E+
Sbjct: 10302 EKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVV 10361
Query: 689 ESPIPIEIPPAAVPSYVPESRERYQQIESYY 719
+ + +E+ A V +PE E + ++E Y+
Sbjct: 10362 KERLELEVVEAEVEE-IPE-EEEFHEVEEYF 10390
Score = 36.6 bits (83), Expect = 0.14
Identities = 50/191 (26%), Positives = 74/191 (38%), Gaps = 29/191 (15%)
Query: 621 VSRFVRPPPSAPE----PAPPYLDHYP-PYLQE----RVVNSQYGTQPQQYPPIYPSHYD 671
+S+ V PPP PE PAP + P P E +V P++ P+ +
Sbjct: 9278 ISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKE 9337
Query: 672 GRRVYPAPSYTREEIFRES-PIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRP 730
P ++ + E P+P+ A P+ VPE ++ E V TQ
Sbjct: 9338 PAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIV----TQREE 9393
Query: 731 SYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSPTLPPTFHPEE 790
S PPP P ++ RK + + EE + PPP P+ LP PEE
Sbjct: 9394 S----------PPPAVPEIPKKKVPEERKPVPRKEEE---VPPPPKVPA--LPKKPVPEE 9438
Query: 791 FLDEDLKVAGK 801
+ + VA K
Sbjct: 9439 KVAVPVPVAKK 9449
Score = 36.2 bits (82), Expect = 0.18
Identities = 33/134 (24%), Positives = 50/134 (37%), Gaps = 23/134 (17%)
Query: 504 VTQLIP-RGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGP 562
V +L+P R +P + LK P P LE V K P P PP+
Sbjct: 10932 VRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKK-----PAVPEPPPPKPV 10986
Query: 563 ADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVS 622
++ VTK + +P +++ P +PA P P+
Sbjct: 10987 EEVEVPTVTKRERKIPEPTKV-----------------PEIKPAIPLPAPEPKPKPEAEV 11029
Query: 623 RFVRPPPSAPEPAP 636
+ ++PPP PEP P
Sbjct: 11030 KTIKPPPVEPEPTP 11043
>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
Length = 1970
Score = 55.1 bits (131), Expect = 4e-07
Identities = 79/329 (24%), Positives = 108/329 (32%), Gaps = 22/329 (6%)
Query: 472 PSAAILPDEGAVDLPSRKP------PALPNGIVSTGNTVTQLIPR--GTDPSYDSSLKPG 523
PS+ +P G PS P P P G + + P T PSY S P
Sbjct: 1577 PSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSY-SPTSPN 1635
Query: 524 KIDHLSSSAPGSP---PDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRG 580
S +P SP P P S S P +P S P P+ P P P P
Sbjct: 1636 YSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSP-SYSPTSPSYSPTSPSYSPTS--PSY 1692
Query: 581 SQLYPAQQ-TDVYYQDPRGAAPPFEPAPYQQGMYYTPP-PQCVSRFVRPPPSAPEPAPPY 638
S P+ T Y + P P+ Y+P P P++P +P
Sbjct: 1693 SPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTS 1752
Query: 639 LDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYP--APSYTREEIFRESPIPIEI 696
++ P + Y Y P P++ Y +PSY+ P
Sbjct: 1753 PNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYT 1812
Query: 697 PPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHR 756
P + P+Y P S SY P +P T PSY P P P+ P+ +
Sbjct: 1813 PQS--PTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSP-EYTPTSPKYSPTSPKYSP 1869
Query: 757 RRKEIMAQLEERKVISPPPFAPSPTLPPT 785
+ +P SPT PT
Sbjct: 1870 TSPKYSPTSPTYSPTTPKYSPTSPTYSPT 1898
Score = 43.5 bits (101), Expect = 0.001
Identities = 65/267 (24%), Positives = 87/267 (32%), Gaps = 16/267 (5%)
Query: 486 PSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSP---PDLLES 542
PS P + S + T T PSY S P S +P SP P
Sbjct: 1690 PSYSPTSPSYSPTSPSYSPTSPSYSPTSPSY-SPTSPSYSPTSPSYSPTSPSYSPTSPNY 1748
Query: 543 VPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQ-TDVYYQDPRGAAP 601
P S + P +P S P P+ P P P P S P+ T Y +
Sbjct: 1749 SPTSPNYTPTSP-SYSPTSPSYSPTSPNYTPTS--PNYSPTSPSYSPTSPSYSPTSPSYS 1805
Query: 602 PFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQ 661
P P Q YTP S PS+P +P + P + +Y +
Sbjct: 1806 PSSPRYTPQSPTYTPSSPSYS------PSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPK 1859
Query: 662 YPPIYPSHYDGRRVYPAPSYTREEIF-RESPIPIEIPPAAVPSYVPESRERYQQIESYYP 720
Y P P + Y S T + SP P + P Y P S + +Y P
Sbjct: 1860 YSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTS-PVYTPTSPKYSPTSPTYSP 1918
Query: 721 VAPHPTQIRPSYLREPPYSRLPPPPQP 747
+P + P+Y P P P
Sbjct: 1919 TSPKYSPTSPTYSPTSPKGSTYSPTSP 1945
>gi|21361320 TRK-fused [Homo sapiens]
Length = 400
Score = 53.9 bits (128), Expect = 8e-07
Identities = 74/323 (22%), Positives = 109/323 (33%), Gaps = 55/323 (17%)
Query: 442 ELEKFRKMNKRLVP-RRPLSASLGQLNEVGLPSAAI-LPDEGAVDLPSRKPPALPNGIVS 499
E + + + + L+ R ++ L L G P + +P+ VD K + +G S
Sbjct: 98 ESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQS 157
Query: 500 T---GNTVTQLIPRGTDPSYDSSLKP--GKIDHLSSSAPGSPPDLLESVPKSISALPVNP 554
T +++ P + ++ G D S P +P + P SI++
Sbjct: 158 TQVMAASMSAFDPLKNQDEINKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAA 217
Query: 555 HSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEP--------A 606
H PP PP + G Q+Y Q Y + APP +P A
Sbjct: 218 H--PPGVQPQQPPYTGAQTQAGQIEG-QMYQQYQQQAGYGAQQPQAPPQQPQQYGIQYSA 274
Query: 607 PYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIY 666
Y Q P Q +P AP PA + QPQQ P
Sbjct: 275 SYSQQTGPQQPQQFQGYGQQPTSQAPAPA-------------------FSGQPQQLPAQP 315
Query: 667 PSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPT 726
P Y YPA +YT + P + PA+ P P YQ
Sbjct: 316 PQQYQASN-YPAQTYTAQT---SQPTNYTVAPASQPGMAPSQPGAYQP------------ 359
Query: 727 QIRPSYLREPPYSRLPPPPQPHP 749
RP + P + PPP P+P
Sbjct: 360 --RPGFTSLPGSTMTPPPSGPNP 380
>gi|56090139 TRK-fused [Homo sapiens]
Length = 400
Score = 53.9 bits (128), Expect = 8e-07
Identities = 74/323 (22%), Positives = 109/323 (33%), Gaps = 55/323 (17%)
Query: 442 ELEKFRKMNKRLVP-RRPLSASLGQLNEVGLPSAAI-LPDEGAVDLPSRKPPALPNGIVS 499
E + + + + L+ R ++ L L G P + +P+ VD K + +G S
Sbjct: 98 ESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQS 157
Query: 500 T---GNTVTQLIPRGTDPSYDSSLKP--GKIDHLSSSAPGSPPDLLESVPKSISALPVNP 554
T +++ P + ++ G D S P +P + P SI++
Sbjct: 158 TQVMAASMSAFDPLKNQDEINKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAA 217
Query: 555 HSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEP--------A 606
H PP PP + G Q+Y Q Y + APP +P A
Sbjct: 218 H--PPGVQPQQPPYTGAQTQAGQIEG-QMYQQYQQQAGYGAQQPQAPPQQPQQYGIQYSA 274
Query: 607 PYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIY 666
Y Q P Q +P AP PA + QPQQ P
Sbjct: 275 SYSQQTGPQQPQQFQGYGQQPTSQAPAPA-------------------FSGQPQQLPAQP 315
Query: 667 PSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPT 726
P Y YPA +YT + P + PA+ P P YQ
Sbjct: 316 PQQYQASN-YPAQTYTAQT---SQPTNYTVAPASQPGMAPSQPGAYQP------------ 359
Query: 727 QIRPSYLREPPYSRLPPPPQPHP 749
RP + P + PPP P+P
Sbjct: 360 --RPGFTSLPGSTMTPPPSGPNP 380
>gi|42544125 splicing factor 1 isoform 2 [Homo sapiens]
Length = 638
Score = 53.5 bits (127), Expect = 1e-06
Identities = 81/331 (24%), Positives = 111/331 (33%), Gaps = 43/331 (12%)
Query: 424 QRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDEGAV 483
QR G P+ A +E L ++ + VP AS+G + A P A
Sbjct: 295 QRPGDPQSAQDKARMDKEYLSLMAELGEAPVP-----ASVGSTSGPATTPLASAPRPAA- 348
Query: 484 DLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDH-LSSSAPGSPPDLLES 542
P+ PP P ++ST TQ P P +S + H + PG P S
Sbjct: 349 --PANNPP--PPSLMST----TQSRP----PWMNSGPSESRPYHGMHGGGPGGPGGGPHS 396
Query: 543 VPKSISALPV----NPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRG 598
P + +L +P P GP P P+ P + D Y
Sbjct: 397 FPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYL----- 451
Query: 599 AAPPFEPAPYQ--QGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYG 656
+ P Y+ QG PPP PPP + +P PP PP+ Q
Sbjct: 452 GSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQ--------- 502
Query: 657 TQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIE 716
Q QQ PP P P P S IPP + Q++
Sbjct: 503 -QQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQ 561
Query: 717 SYYPVAPHPTQIRPSYLREPPYSRLPPPPQP 747
+ P P ++P PP + PPPP P
Sbjct: 562 GNPTMVPLPPGVQPPL---PPGAPPPPPPPP 589
>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
Length = 2217
Score = 53.5 bits (127), Expect = 1e-06
Identities = 78/274 (28%), Positives = 104/274 (37%), Gaps = 22/274 (8%)
Query: 486 PSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSS-SAPGSPPDLLESVP 544
P +P LP + Q +P P + + G L P +P L VP
Sbjct: 733 PLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVP 792
Query: 545 KSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA--PP 602
+ +PV P P G LPP P VP + P Q P AA PP
Sbjct: 793 PQMPPIPVVPPITPLAGIDGLPPALPDLPTATVP---PVPPPQYFSPAVILPSLAAPLPP 849
Query: 603 FEPA-PYQQGMYYTPPPQCVSRFVRP-PPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ 660
PA P Q PP ++ R P+AP P L PP + ++S P
Sbjct: 850 ASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATI-PLLAVAPPGVAALSIHSAVAQLPG 908
Query: 661 QYPPIYPSHYDGRR---VYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIES 717
Q P+YP+ + V P+P +T + + R +P +PP P+ P+ Q
Sbjct: 909 Q--PVYPAAFPQMAPTDVPPSPHHTVQNM-RATPPQPALPPQ--PTLPPQPVLPPQPTLP 963
Query: 718 YYPVAPHPTQIRPSYLREPPYSRLPP----PPQP 747
PV P P RP PP LPP PPQP
Sbjct: 964 PQPVLP-PQPTRPPQPVLPPQPMLPPQPVLPPQP 996
Score = 48.5 bits (114), Expect = 4e-05
Identities = 80/310 (25%), Positives = 109/310 (35%), Gaps = 62/310 (20%)
Query: 455 PRRPLSASLGQLNEVGLPSAAILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDP 514
P PL + + G P P+E D PP LP S + T +G+
Sbjct: 567 PPVPLQVQVTYHAQAGQPGPPE-PEEPEAD-QHLLPPTLPTSATSLASDSTFDSGQGSTV 624
Query: 515 SYDS--SLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTK 572
DS S + + L+ +AP SP + S P +S PV P S+P G P
Sbjct: 625 YSDSQSSQQSVMLGSLADAAP-SPAQCVCSPP--VSEGPVLPQSLPSLGAYQQPTAAPGL 681
Query: 573 PLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAP 632
P+ VP AP P+ Q + P P V PPPS P
Sbjct: 682 PVGSVP---------------------APACPPSLQQ----HFPDPAMSFAPVLPPPSTP 716
Query: 633 ------EPAPPYLDHYPPYLQERVVNSQYGTQP----QQYPPIYPSHYDGRRVYPAPSYT 682
+PAPP PP Q + QP Q PP P + AP+
Sbjct: 717 MPTGPGQPAPPG-QQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQL 775
Query: 683 REEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIR-----PSYLREPP 737
+ ++P+ P A VP +P PV P T + P L + P
Sbjct: 776 KPLQMPQAPLQ---PLAQVPPQMPP-----------IPVVPPITPLAGIDGLPPALPDLP 821
Query: 738 YSRLPPPPQP 747
+ +PP P P
Sbjct: 822 TATVPPVPPP 831
Score = 41.2 bits (95), Expect = 0.006
Identities = 62/247 (25%), Positives = 83/247 (33%), Gaps = 47/247 (19%)
Query: 522 PGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMP--------VTKP 573
P I L+ + PG + S + PV P + P P D+PP P T P
Sbjct: 881 PATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPP 940
Query: 574 LQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYYTPP-PQCVSRFVRPP---- 628
+P L P Q + Q P P P + PP P + V PP
Sbjct: 941 QPALPPQPTLPP--QPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPAL 998
Query: 629 PSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFR 688
P PEP P+L P+Q P +PAP Y + +
Sbjct: 999 PVRPEPLQPHL-------------------PEQAAPAATPGSQILLGHPAP-YAVDVAAQ 1038
Query: 689 ESPIPIEIPPAAVPS------YVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLP 742
+P +PPAAV S +P + E Q S Q P+ + LP
Sbjct: 1039 VPTVP--VPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTA----TLLP 1092
Query: 743 PPPQPHP 749
P P P
Sbjct: 1093 PANPPLP 1099
Score = 40.4 bits (93), Expect = 0.010
Identities = 81/346 (23%), Positives = 117/346 (33%), Gaps = 75/346 (21%)
Query: 459 LSASLGQLNEVGLPSAAILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDS 518
L SL L P+AA G+V P+ PP+L + ++P PS
Sbjct: 662 LPQSLPSLGAYQQPTAAPGLPVGSVPAPAC-PPSLQQHFPDPAMSFAPVLP---PPSTPM 717
Query: 519 SLKPGKIDHLSSSAPGS-PPDLLES--VPKSISALPVNP-HSIPPRGPADLPPMPVTKPL 574
PG+ + PG PP L + +P+ ++ PV P +PP P P P
Sbjct: 718 PTGPGQ-----PAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLP------PYLAPA 766
Query: 575 QMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPE- 633
V +QL P Q Q P P P PP ++ PP+ P+
Sbjct: 767 SQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPIPV------VPPITPLAGIDGLPPALPDL 820
Query: 634 ------PAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIF 687
P PP P Y V+ P P+ P+ PA ++
Sbjct: 821 PTATVPPVPP-----PQYFSPAVI------LPSLAAPLPPAS-------PALPLQAVKLP 862
Query: 688 RESPIPIEIP--------PAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLRE-PPY 738
P+ +P PA +P + + + + VA P Q P Y P
Sbjct: 863 HPPGAPLAMPCRTIVPNAPATIP-LLAVAPPGVAALSIHSAVAQLPGQ--PVYPAAFPQM 919
Query: 739 SRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSPTLPP 784
+ PP PH ++ + R P P PTLPP
Sbjct: 920 APTDVPPSPHHTVQNM-------------RATPPQPALPPQPTLPP 952
Score = 31.6 bits (70), Expect = 4.5
Identities = 26/81 (32%), Positives = 32/81 (39%), Gaps = 5/81 (6%)
Query: 720 PVAPHPTQIRPSYLREPPYSRLPPPPQPH--PSLDELHRRRKE---IMAQLEERKVISPP 774
PVA HP P P S LPP P D+L + + QL + S P
Sbjct: 1317 PVAEHPAPEAPESSPPLPLSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNP 1376
Query: 775 PFAPSPTLPPTFHPEEFLDED 795
P AP L P+ P L +D
Sbjct: 1377 PGAPPAPLAPSSPPVTALPQD 1397
Score = 31.6 bits (70), Expect = 4.5
Identities = 43/190 (22%), Positives = 59/190 (31%), Gaps = 47/190 (24%)
Query: 486 PSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPK 545
PS P A P + + VT L G P+ + +P + PG+P L +
Sbjct: 1373 PSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELET 1432
Query: 546 SISALPVNPHSIPPRGPADLPPMPV-TKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFE 604
S P + P + P+ V P P + R A+ P E
Sbjct: 1433 S------QPLAETHEAPLAVQPLVVGLAPCTPAPEAAST-------------RDASAPRE 1473
Query: 605 PAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAP------PYLDHYPPYLQERVVNSQYGTQ 658
P P P APEP+P P L P L V T
Sbjct: 1474 PLP---------------------PPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATS 1512
Query: 659 PQQYPPIYPS 668
PP+ P+
Sbjct: 1513 QLPSPPLGPT 1522
>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
Length = 1094
Score = 53.5 bits (127), Expect = 1e-06
Identities = 77/306 (25%), Positives = 105/306 (34%), Gaps = 44/306 (14%)
Query: 455 PRRPLSASLGQLNEVGLPSAAILPDEGAVDLPSRKPPALPNGIVS-------TGNTVTQL 507
P R LS S G ++ G P+ G P + P P + S +++T L
Sbjct: 574 PERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSL 633
Query: 508 IPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPP 567
+DP+ P + L P VP S P P S P PA P
Sbjct: 634 CSSSSDPAPSDRSGPQILTPLGDRFVIPPHP---KVPAPFSPPPSKPRSPNPAAPALAAP 690
Query: 568 MPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVSRFVRP 627
V P+ Q P QT + P + +P +PPP P
Sbjct: 691 AVVPGPVSTTDASPQSPPTPQTTL---------TPLQESPV-ISKDQSPPPS-------P 733
Query: 628 PPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQ---YPPIYPSHYDGRRVYPAPSYTRE 684
PPS P PP P + E S+ +P Q +PP P + + + A E
Sbjct: 734 PPSYHPPPPP--TKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPE 791
Query: 685 EIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPP 744
E F + P A PS PE S + QI+P +PP P P
Sbjct: 792 EAF----FSVASPEPAGPSGSPELVSSPAASSS----SATALQIQPPGSPDPP----PAP 839
Query: 745 PQPHPS 750
P P P+
Sbjct: 840 PAPAPA 845
Score = 40.0 bits (92), Expect = 0.013
Identities = 98/406 (24%), Positives = 142/406 (34%), Gaps = 57/406 (14%)
Query: 399 SKKGADQQQPPQHSKYKTYMCRDMKQRG-GCPRGASCTFAHSQEELEKFRKMNKRLVPRR 457
S KG + QP + + + G G P G S A + +++ R V R
Sbjct: 433 SSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLR 492
Query: 458 PLSASLGQLNEV-GLPSAAILPDEGAVDLPSR----KPPALPNGIVSTGNTVTQLIPRGT 512
L L + +G + LP + + P LP + G+ P
Sbjct: 493 KLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPP 552
Query: 513 DPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTK 572
+P+ +S PG S P SP L P S + ++PP+G A PP K
Sbjct: 553 NPA--NSWVPGLSPGGSRRPPRSPERTLS--PSSGYSSQSGTPTLPPKGLAG-PPASPGK 607
Query: 573 PLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVS----RFVRPP 628
P + V + +PAP + PQ ++ RFV PP
Sbjct: 608 AQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRS-----GPQILTPLGDRFVIPP 662
Query: 629 -PSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYP---SHYDGRRVYPAPSYTRE 684
P P P P P + R N P + P S D P T
Sbjct: 663 HPKVPAPFSP------PPSKPRSPNP--AAPALAAPAVVPGPVSTTDASPQSPPTPQTTL 714
Query: 685 EIFRESPIPIEI---PPAAVPSY---VPESRERYQQIESYYPVAPHPTQIRPSYLREPPY 738
+ESP+ + PP+ PSY P +++ +E AP ++ L++P +
Sbjct: 715 TPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVE-----APSASETAEEPLQDPNW 769
Query: 739 SRLPPPPQPHPSLDELHRRRKEIMAQL---EER--KVISPPPFAPS 779
PPPP P P +L MA EE V SP P PS
Sbjct: 770 ---PPPPPPAPEEQDLS------MADFPPPEEAFFSVASPEPAGPS 806
Score = 32.0 bits (71), Expect = 3.4
Identities = 46/194 (23%), Positives = 58/194 (29%), Gaps = 45/194 (23%)
Query: 602 PFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYL-------DHYPPYLQERVVNSQ 654
P +P QQ PP S P P PA ++ PP ER ++
Sbjct: 522 PPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPS 581
Query: 655 YGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQ 714
G Q P P P + PPA+ P ER
Sbjct: 582 SGYSSQSGTPTLP-----------------------PKGLAGPPASPGKAQPPKPERVTS 618
Query: 715 IESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPP 774
+ S P S L S P P R +I+ L +R VI P
Sbjct: 619 LRS-------PGASVSSSLTSLCSSSSDPAPSD--------RSGPQILTPLGDRFVIPPH 663
Query: 775 PFAPSPTLPPTFHP 788
P P+P PP P
Sbjct: 664 PKVPAPFSPPPSKP 677
>gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]
Length = 1711
Score = 53.1 bits (126), Expect = 1e-06
Identities = 77/299 (25%), Positives = 105/299 (35%), Gaps = 57/299 (19%)
Query: 471 LPSAAILPDEGAVDLPSRKPPA------LPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGK 524
LP+ P G+ +P P A +P + +G Q+ PS + P
Sbjct: 199 LPAPICPPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPA- 257
Query: 525 IDHLSSSAPGSPPDLLESVPKSISA---LPVNPHSIPPRGPADLPPMPVTKPLQMVPRGS 581
L+ + P P + +S P S+SA +PV P S PP GP L P PL VP +
Sbjct: 258 ---LAPAPPSVPTLISDSNPLSVSASVLVPV-PASAPPSGPVPLSA-PAPAPLS-VPVSA 311
Query: 582 QLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDH 641
Q V P P P P M + PP + PPS P P P
Sbjct: 312 PPLALIQAPVPPSAPTLVLAPV-PTPVLAPMPASTPPAAPA-----PPSVPMPTPT---- 361
Query: 642 YPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAV 701
P PP P+ P P+ T IF +P P+ PAA
Sbjct: 362 -----------------PSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPM---PAAT 401
Query: 702 PSYVPESR---ERYQQIESYYPVAPHPT------QIRPSYLREP--PYSRLPPPPQPHP 749
P+ +P S + +P A P +P + P P +PPP P
Sbjct: 402 PAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQP 460
>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
Length = 1295
Score = 52.4 bits (124), Expect = 2e-06
Identities = 73/290 (25%), Positives = 107/290 (36%), Gaps = 49/290 (16%)
Query: 504 VTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKS-ISALPVNPHSIPPRGP 562
V +L+P+ PS S L SS+P + P ++ + + +LP+ P P R P
Sbjct: 1022 VEELLPQHLQPSSSSGLGTSP-----SSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTP 1076
Query: 563 ADLPPMPVTKPLQMVPRGS--QLYPAQQTDVYYQDP-RGAAPPFEPAPYQQGMYYTPPPQ 619
PP + P+ P Q PAQ + P R APP PAP Q+ PP
Sbjct: 1077 G--PPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQR-----PP-- 1127
Query: 620 CVSRFVRPPPSAPEPAPPYLDHYPP-----YLQERVVNSQYGTQPQQYPPIYPSHYDGRR 674
PP A PAP + P ++ + SQ Q P P+ Y R
Sbjct: 1128 -------PPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGP-GPAGYSTAR 1179
Query: 675 VYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLR 734
P R + P A+ PES+ + + P P + + ++
Sbjct: 1180 PTIPP---RAGVI---SAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAF-- 1231
Query: 735 EPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSPTLPP 784
PP S LPPP Q R ++ ++ P P +P PP
Sbjct: 1232 -PPQSSLPPPAQ---------RLQEPLVPVAAPMPQSGPQPNLETPPQPP 1271
>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
Length = 1526
Score = 52.4 bits (124), Expect = 2e-06
Identities = 74/271 (27%), Positives = 102/271 (37%), Gaps = 41/271 (15%)
Query: 504 VTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKS-ISALPVNPHSIPPRGP 562
V +L+P+ PS S L SS+P + P ++ + + +LP+ P P R P
Sbjct: 1017 VEELLPQHLQPSSSSGLGTSP-----SSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTP 1071
Query: 563 ADLPPMPVTKPLQMVPRGS--QLYPAQQTDVYYQDP-RGAAPPFEPAPYQQGMYYTPPPQ 619
PP + P+ P Q PAQ + P R APP PAP Q+ PPP
Sbjct: 1072 G--PPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQR-----PPPP 1124
Query: 620 CVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAP 679
P P P P + R + + PQ + + R+ P
Sbjct: 1125 SGRSQPSPQAGLAGPGPAGYSTARPTIPPR---AGVISAPQSH-----ARASAGRLTPES 1176
Query: 680 SYTREEIFRES---PIPIEIPPAAVP--SYVPESRERYQQIESYYPV-APHPTQIRPSYL 733
E + S P P++ P AA P S +P +R Q E PV AP P
Sbjct: 1177 QSKTSETSKGSTFLPEPLK-PQAAFPPQSSLPPPAQRLQ--EPLVPVAAPMP-------- 1225
Query: 734 REPPYSRLPPPPQPHPSLDELHRRRKEIMAQ 764
+ P L PPQP P H E +Q
Sbjct: 1226 QSGPQPNLETPPQPPPRSRSSHSLPSEASSQ 1256
>gi|155030236 ribonuclease III, nuclear isoform 2 [Homo sapiens]
Length = 1337
Score = 51.6 bits (122), Expect = 4e-06
Identities = 50/183 (27%), Positives = 66/183 (36%), Gaps = 42/183 (22%)
Query: 554 PHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMY 613
P +PP LPP P+ P P +P + PP P P +
Sbjct: 82 PPPMPPSAQGPLPPCPIRPPF---PNHQMRHPFPVPPCF-----PPMPPPMPCPNNPPVP 133
Query: 614 YTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGR 673
PP Q F+ PPPS P P P PP + ++V QYPP Y H
Sbjct: 134 GAPPGQGTFPFMMPPPSMPHPPP------PPVMPQQV--------NYQYPPGYSHHN--- 176
Query: 674 RVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYL 733
+P PS+ F+ + P P+A S P R + P+P PS
Sbjct: 177 --FPPPSFNS---FQNN--PSSFLPSANNSSSPHFRH----------LPPYPLPKAPSER 219
Query: 734 REP 736
R P
Sbjct: 220 RSP 222
Score = 42.0 bits (97), Expect = 0.003
Identities = 48/199 (24%), Positives = 66/199 (33%), Gaps = 33/199 (16%)
Query: 489 KPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSIS 548
+PP+ P+ S L PR + + P S+ P P + P
Sbjct: 54 EPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPP------SAQGPLPPCPIRPPFPNHQM 107
Query: 549 ALPVNPHSIPPRGPADLPPMPV--TKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPA 606
+P +PP P PPMP P+ P G +P P PP
Sbjct: 108 R---HPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHP----PPPPVM 160
Query: 607 PYQQGMYYTP-------PPQCVSRFVRPP----PSAPEPAPPYLDHYPPYLQERVVNSQY 655
P Q Y P PP + F P PSA + P+ H PPY + +
Sbjct: 161 PQQVNYQYPPGYSHHNFPPPSFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPS--- 217
Query: 656 GTQPQQYPPIYPSHYDGRR 674
++ P HYD R
Sbjct: 218 ----ERRSPERLKHYDDHR 232
>gi|155030234 ribonuclease III, nuclear isoform 1 [Homo sapiens]
Length = 1374
Score = 51.6 bits (122), Expect = 4e-06
Identities = 50/183 (27%), Positives = 66/183 (36%), Gaps = 42/183 (22%)
Query: 554 PHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMY 613
P +PP LPP P+ P P +P + PP P P +
Sbjct: 82 PPPMPPSAQGPLPPCPIRPPF---PNHQMRHPFPVPPCF-----PPMPPPMPCPNNPPVP 133
Query: 614 YTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGR 673
PP Q F+ PPPS P P P PP + ++V QYPP Y H
Sbjct: 134 GAPPGQGTFPFMMPPPSMPHPPP------PPVMPQQV--------NYQYPPGYSHHN--- 176
Query: 674 RVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYL 733
+P PS+ F+ + P P+A S P R + P+P PS
Sbjct: 177 --FPPPSFNS---FQNN--PSSFLPSANNSSSPHFRH----------LPPYPLPKAPSER 219
Query: 734 REP 736
R P
Sbjct: 220 RSP 222
Score = 42.0 bits (97), Expect = 0.003
Identities = 48/199 (24%), Positives = 66/199 (33%), Gaps = 33/199 (16%)
Query: 489 KPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSIS 548
+PP+ P+ S L PR + + P S+ P P + P
Sbjct: 54 EPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPP------SAQGPLPPCPIRPPFPNHQM 107
Query: 549 ALPVNPHSIPPRGPADLPPMPV--TKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPA 606
+P +PP P PPMP P+ P G +P P PP
Sbjct: 108 R---HPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHP----PPPPVM 160
Query: 607 PYQQGMYYTP-------PPQCVSRFVRPP----PSAPEPAPPYLDHYPPYLQERVVNSQY 655
P Q Y P PP + F P PSA + P+ H PPY + +
Sbjct: 161 PQQVNYQYPPGYSHHNFPPPSFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPS--- 217
Query: 656 GTQPQQYPPIYPSHYDGRR 674
++ P HYD R
Sbjct: 218 ----ERRSPERLKHYDDHR 232
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,385,695
Number of Sequences: 37866
Number of extensions: 3159863
Number of successful extensions: 22260
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 133
Number of HSP's successfully gapped in prelim test: 902
Number of HSP's that attempted gapping in prelim test: 15405
Number of HSP's gapped (non-prelim): 6211
length of query: 1133
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1020
effective length of database: 13,968,660
effective search space: 14248033200
effective search space used: 14248033200
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.