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Search of human proteins with 71725341
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
sapiens]
(442 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo sa... 889 0.0
gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo sa... 879 0.0
gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo sa... 858 0.0
gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo sa... 849 0.0
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa... 711 0.0
gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo sa... 681 0.0
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens] 616 e-176
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 268 6e-72
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 261 7e-70
gi|11415052 retinoid X receptor, beta [Homo sapiens] 261 7e-70
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 229 5e-60
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 223 2e-58
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 219 3e-57
gi|238550159 estrogen-related receptor beta [Homo sapiens] 184 1e-46
gi|7657395 photoreceptor-specific nuclear receptor isoform b [Ho... 184 1e-46
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 178 8e-45
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 178 8e-45
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 178 8e-45
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 178 8e-45
gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo... 177 1e-44
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 169 6e-42
gi|18860920 estrogen-related receptor alpha [Homo sapiens] 162 7e-40
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 161 1e-39
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 161 1e-39
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 161 1e-39
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 160 3e-39
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 160 3e-39
gi|7706515 photoreceptor-specific nuclear receptor isoform a [Ho... 155 5e-38
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 145 7e-35
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 144 1e-34
>gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
sapiens]
Length = 442
Score = 889 bits (2296), Expect = 0.0
Identities = 442/442 (100%), Positives = 442/442 (100%)
Query: 1 MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG 60
MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG
Sbjct: 1 MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG 60
Query: 61 FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS 120
FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS
Sbjct: 61 FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS 120
Query: 121 SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA 180
SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA
Sbjct: 121 SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA 180
Query: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240
KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS
Sbjct: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240
Query: 241 RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300
RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY
Sbjct: 241 RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300
Query: 301 INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDA 360
INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDA
Sbjct: 301 INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDA 360
Query: 361 PHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMSTPETPQPSPPGGSGSEPYKLLPGA 420
PHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMSTPETPQPSPPGGSGSEPYKLLPGA
Sbjct: 361 PHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMSTPETPQPSPPGGSGSEPYKLLPGA 420
Query: 421 VATIVKPLSAIPQPTITKQEVI 442
VATIVKPLSAIPQPTITKQEVI
Sbjct: 421 VATIVKPLSAIPQPTITKQEVI 442
>gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo
sapiens]
Length = 452
Score = 879 bits (2272), Expect = 0.0
Identities = 441/452 (97%), Positives = 442/452 (97%), Gaps = 10/452 (2%)
Query: 1 MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG 60
MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG
Sbjct: 1 MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG 60
Query: 61 FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS 120
FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS
Sbjct: 61 FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS 120
Query: 121 SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA 180
SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA
Sbjct: 121 SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA 180
Query: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240
KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS
Sbjct: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240
Query: 241 RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300
RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY
Sbjct: 241 RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300
Query: 301 INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDA 360
INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDA
Sbjct: 301 INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDA 360
Query: 361 PHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQM----------STPETPQPSPPGGSG 410
PHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQM +TPETPQPSPPGGSG
Sbjct: 361 PHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSG 420
Query: 411 SEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 442
SEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
Sbjct: 421 SEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 452
>gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo
sapiens]
Length = 464
Score = 858 bits (2217), Expect = 0.0
Identities = 426/426 (100%), Positives = 426/426 (100%)
Query: 17 DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 76
DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF
Sbjct: 39 DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 98
Query: 77 SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 136
SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA
Sbjct: 99 SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 158
Query: 137 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA
Sbjct: 159 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 218
Query: 197 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 256
LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE
Sbjct: 219 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 278
Query: 257 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 316
LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL
Sbjct: 279 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 338
Query: 317 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM 376
LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM
Sbjct: 339 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM 398
Query: 377 GTNVIVANTMPTHLSNGQMSTPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTI 436
GTNVIVANTMPTHLSNGQMSTPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTI
Sbjct: 399 GTNVIVANTMPTHLSNGQMSTPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTI 458
Query: 437 TKQEVI 442
TKQEVI
Sbjct: 459 TKQEVI 464
>gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
sapiens]
Length = 474
Score = 849 bits (2193), Expect = 0.0
Identities = 425/436 (97%), Positives = 426/436 (97%), Gaps = 10/436 (2%)
Query: 17 DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 76
DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF
Sbjct: 39 DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 98
Query: 77 SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 136
SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA
Sbjct: 99 SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 158
Query: 137 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA
Sbjct: 159 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 218
Query: 197 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 256
LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE
Sbjct: 219 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 278
Query: 257 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 316
LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL
Sbjct: 279 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 338
Query: 317 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM 376
LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM
Sbjct: 339 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHM 398
Query: 377 GTNVIVANTMPTHLSNGQM----------STPETPQPSPPGGSGSEPYKLLPGAVATIVK 426
GTNVIVANTMPTHLSNGQM +TPETPQPSPPGGSGSEPYKLLPGAVATIVK
Sbjct: 399 GTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVK 458
Query: 427 PLSAIPQPTITKQEVI 442
PLSAIPQPTITKQEVI
Sbjct: 459 PLSAIPQPTITKQEVI 474
>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
sapiens]
Length = 395
Score = 711 bits (1835), Expect = 0.0
Identities = 360/375 (96%), Positives = 360/375 (96%), Gaps = 13/375 (3%)
Query: 1 MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG 60
MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG
Sbjct: 1 MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG 60
Query: 61 FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS 120
FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS
Sbjct: 61 FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS 120
Query: 121 SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA 180
SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA
Sbjct: 121 SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA 180
Query: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240
KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS
Sbjct: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240
Query: 241 RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300
RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY
Sbjct: 241 RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300
Query: 301 INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG----- 355
INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG
Sbjct: 301 INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQ 360
Query: 356 --------SPSDAPH 362
SP D PH
Sbjct: 361 EGRGWSGDSPGDRPH 375
>gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo
sapiens]
Length = 417
Score = 681 bits (1756), Expect = 0.0
Identities = 344/359 (95%), Positives = 344/359 (95%), Gaps = 13/359 (3%)
Query: 17 DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 76
DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF
Sbjct: 39 DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 98
Query: 77 SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 136
SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA
Sbjct: 99 SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 158
Query: 137 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA
Sbjct: 159 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 218
Query: 197 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 256
LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE
Sbjct: 219 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 278
Query: 257 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 316
LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL
Sbjct: 279 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 338
Query: 317 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG-------------SPSDAPH 362
LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG SP D PH
Sbjct: 339 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPGDRPH 397
>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
Length = 445
Score = 616 bits (1588), Expect = e-176
Identities = 305/411 (74%), Positives = 350/411 (85%), Gaps = 3/411 (0%)
Query: 14 SSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYS 73
+S D+S E T++N ++ GV+ LCAICGDRATGKHYGASSCDGCKGFFRRS+RK+H+YS
Sbjct: 27 NSSDSSAPE-TSMNTTDN-GVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYS 84
Query: 74 CRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL 133
CRFSRQCVVDKDKRNQCRYCRL+KCFRAGMKKEAVQNERDRISTRRS+++ S++PSIN L
Sbjct: 85 CRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTL 144
Query: 134 LQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDD 193
QAEV SRQI+ G + DI KKIASI DVCESMK+QLLVLVEWAKYIPAFCELPLDD
Sbjct: 145 AQAEVRSRQISVSSPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDD 204
Query: 194 QVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLP 253
QVALLRAHAGEHLLLGATKRSM++KD+LLLGN+Y++ R+ E+ E+SRV+ R+LDELV P
Sbjct: 205 QVALLRAHAGEHLLLGATKRSMMYKDILLLGNNYVIHRNSCEV-EISRVANRVLDELVRP 263
Query: 254 FQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFG 313
FQE+QIDDNEYA LKAI+FFDPDAKGLSDP KIK +R QVQ+ LEDYINDRQYDSRGRFG
Sbjct: 264 FQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFG 323
Query: 314 ELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQ 373
ELLLLLPTLQSITWQMIEQIQF+KLFGM KIDNLLQEMLLGG+ +D H HHP+HPHL Q
Sbjct: 324 ELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLGGASNDGSHLHHPMHPHLSQ 383
Query: 374 EHMGTNVIVANTMPTHLSNGQMSTPETPQPSPPGGSGSEPYKLLPGAVATI 424
+ + I+ M T + Q+STPETP PSPP GSG E YK+ + I
Sbjct: 384 DPLTGQTILLGPMSTLVHADQISTPETPLPSPPQGSGQEQYKIAANQASVI 434
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 268 bits (686), Expect = 6e-72
Identities = 153/366 (41%), Positives = 215/366 (58%), Gaps = 20/366 (5%)
Query: 11 PVESSYDTSPSEGTN--LNAP-NSLGVSA-----LCAICGDRATGKHYGASSCDGCKGFF 62
PV SS D P G N L P + G A +CAICGDR++GKHYG SC+GCKGFF
Sbjct: 100 PVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFF 159
Query: 63 RRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSY 122
+R+VRK+ Y+CR ++ C++DK +RN+C+YCR +KC GMK+EAVQ ER R R +
Sbjct: 160 KRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENE 219
Query: 123 EDSSLPS-----INALLQAEVLSRQITSPVSGINGDIRAKKIAS-IADVCESMKEQLLVL 176
+S+ + + +L+AE+ T N + + ++C++ +QL L
Sbjct: 220 VESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTL 279
Query: 177 VEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPEL 236
VEWAK IP F ELPLDDQV LLRA E L+ + RS+ KD +LL V R+
Sbjct: 280 VEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHS 339
Query: 237 AEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVS 296
A + + R+L ELV +++Q+D E L+AI+ F+PD+KGLS+P +++ LR +V S
Sbjct: 340 AGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYAS 399
Query: 297 LEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGS 356
LE Y + + GRF +LLL LP L+SI + +E + F KL G ID L EML
Sbjct: 400 LEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML---- 455
Query: 357 PSDAPH 362
+APH
Sbjct: 456 --EAPH 459
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 261 bits (668), Expect = 7e-70
Identities = 142/351 (40%), Positives = 210/351 (59%), Gaps = 10/351 (2%)
Query: 12 VESSYDTSPSEGT----NLNAPNSLG---VSALCAICGDRATGKHYGASSCDGCKGFFRR 64
V SS D P G N+N P++ V +CAICGDR++GKHYG SC+GCKGFF+R
Sbjct: 106 VSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKR 165
Query: 65 SVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED 124
++RK+ +Y+CR ++ C++DK +RN+C+YCR +KC GMK+EAVQ ER R R S +
Sbjct: 166 TIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAE 225
Query: 125 SSLPSINALLQAEVLSRQIT-SPVSGINGDIRAKKIAS--IADVCESMKEQLLVLVEWAK 181
+ + +L ++ P + GD+ + + + ++C + +QL LVEWAK
Sbjct: 226 CATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAK 285
Query: 182 YIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSR 241
IP F +L L+DQV LLRA E L+ + RS+ +D +LL V R A +
Sbjct: 286 RIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGS 345
Query: 242 VSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYI 301
+ R+L ELV +++Q+D +E L+AI+ F+PDAKGLS+P +++ LR +V +LE Y
Sbjct: 346 IFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYT 405
Query: 302 NDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
+ + GRF +LLL LP L+SI + +E + F KL G ID L EML
Sbjct: 406 KQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 456
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 261 bits (668), Expect = 7e-70
Identities = 144/336 (42%), Positives = 204/336 (60%), Gaps = 19/336 (5%)
Query: 37 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
LCAICGDR++GKHYG SC+GCKGFF+R++RK+ YSCR ++ C VDK +RN+C+YCR +
Sbjct: 204 LCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQ 263
Query: 97 KCFRAGMKKEAVQNERDRISTRRSSYEDSS-----LPSINALLQAEVLSRQ-----ITSP 146
KC GMK+EAVQ ER R + E + +P ++ +L+AE+ Q + P
Sbjct: 264 KCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP-VDRILEAELAVEQKSDQGVEGP 322
Query: 147 VSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL 206
G G + + ++C++ +QL LVEWAK IP F LPLDDQV LLRA E L
Sbjct: 323 --GGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELL 380
Query: 207 LLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAY 266
+ + RS+ +D +LL V R+ A + + R+L ELV +++++D E
Sbjct: 381 IASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGC 440
Query: 267 LKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSIT 326
L+AII F+PDAKGLS+P +++ LR +V SLE Y + + +GRF +LLL LP L+SI
Sbjct: 441 LRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIG 500
Query: 327 WQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 362
+ +E + F KL G ID L EML +APH
Sbjct: 501 LKCLEHLFFFKLIGDTPIDTFLMEML------EAPH 530
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 229 bits (583), Expect = 5e-60
Identities = 135/353 (38%), Positives = 191/353 (54%), Gaps = 26/353 (7%)
Query: 33 GVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRY 92
G+ C +CGD+++GKHYG +C+GCK FF+RS+R+N Y+CR +R C +D+ RNQC+Y
Sbjct: 51 GLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQY 110
Query: 93 CRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL-----------------LQ 135
CRLKKCFR GM+KEAVQ R S + S P +AL L
Sbjct: 111 CRLKKCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELI 170
Query: 136 AEVLSRQITSPVSGI--NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDD 193
A++L + +G G A + I +VCE L VEWA++ P F ELP+ D
Sbjct: 171 AQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVAD 230
Query: 194 QVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDE 249
QVALLR E +L A + ++ LL H +A V+ +R E
Sbjct: 231 QVALLRLSWSELFVLNAAQAALPLHTAPLLA---AAGLHAAPMAAERAVAFMDQVRAFQE 287
Query: 250 LVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSR 309
V LQ+D EY LKAI F PDA GLSDP ++ L+ + QV+L +Y+ +
Sbjct: 288 QVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQP 347
Query: 310 GRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 362
RFG LLL LP L+++ +I Q+ F++L G I+ L+++MLL GS + P+
Sbjct: 348 QRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPY 400
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 223 bits (569), Expect = 2e-58
Identities = 129/337 (38%), Positives = 194/337 (57%), Gaps = 17/337 (5%)
Query: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
Query: 98 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQIT-------SPVSGI 150
C + GM++EAVQ R R+ + ++ +L + + L LS I+ P S
Sbjct: 139 CLKVGMRREAVQ--RGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRF 196
Query: 151 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 209
++ I I ++CE L VEWA+ IP F +L + DQVALLR E +L
Sbjct: 197 GSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLN 256
Query: 210 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 265
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 257 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 313
Query: 266 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 325
LKAI+ F DA GLSD ++ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 314 CLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTV 373
Query: 326 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 362
+ +IEQ+ F++L G I+ L+++MLL GS + P+
Sbjct: 374 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 410
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 219 bits (559), Expect = 3e-57
Identities = 128/337 (37%), Positives = 192/337 (56%), Gaps = 17/337 (5%)
Query: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
Query: 98 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALL-------QAEVLSRQITSPVSGI 150
C + GM++EAVQ R R+ + + +L + + L +L R P S
Sbjct: 146 CLKVGMRREAVQ--RGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRY 203
Query: 151 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 209
++ I I ++CE L VEWA+ IP F +L + DQV+LLR E +L
Sbjct: 204 GSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLN 263
Query: 210 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 265
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 264 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 320
Query: 266 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 325
LKAI+ F DA GLSD I+ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 321 CLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380
Query: 326 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 362
+ +IEQ+ F++L G I+ L+++MLL GS + P+
Sbjct: 381 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 417
>gi|238550159 estrogen-related receptor beta [Homo sapiens]
Length = 508
Score = 184 bits (468), Expect = 1e-46
Identities = 121/388 (31%), Positives = 193/388 (49%), Gaps = 37/388 (9%)
Query: 9 GAPVESSYDTSPS---EGTNLNAPNSLGV--SALCAICGDRATGKHYGASSCDGCKGFFR 63
G P SY+ S E + + L LC +CGD A+G HYG +SC+ CK FF+
Sbjct: 69 GTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFK 128
Query: 64 RSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRIS----TRR 119
R+++ N YSC + +C + K +R C+ CR KC + GM KE V+ +R R RR
Sbjct: 129 RTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRR 188
Query: 120 SSYEDSSLPS--------------INALLQAEVLSRQITSPVSGINGDIRAKKIASIADV 165
E S S ++ LL AE P GDI+A + +
Sbjct: 189 LDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKA-----LTTL 243
Query: 166 CESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGN 225
C+ +L+V++ WAK+IP F L L DQ++LL++ E L+LG RS+ + D L+
Sbjct: 244 CDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAE 303
Query: 226 DYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGK 285
DYI+ LA + + IL +LV +++L+++ E+ LKA+ + D+ + D
Sbjct: 304 DYIMDEEHSRLAGLLELYRAIL-QLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEA 362
Query: 286 IKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKID 345
+++L+ + +L+DY ++++ R G+LLL LP L+ + ++ +KL G +
Sbjct: 363 VQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMH 422
Query: 346 NLLQEML--------LGGSPSDAPHAHH 365
L EML L GSP D + H
Sbjct: 423 KLFLEMLEAKVGQEQLRGSPKDERMSSH 450
>gi|7657395 photoreceptor-specific nuclear receptor isoform b [Homo
sapiens]
Length = 410
Score = 184 bits (468), Expect = 1e-46
Identities = 130/396 (32%), Positives = 187/396 (47%), Gaps = 47/396 (11%)
Query: 3 SVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFF 62
+V A A +S SP P + S C +CGD ++GKHYG +C+GC GFF
Sbjct: 12 TVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFF 71
Query: 63 RRSVRKNHMYSCRF-SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRR-- 119
+RSVR+ +Y C+ + C VDK RNQC+ CRLKKC +AGM ++AVQNER ST +
Sbjct: 72 KRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVH 131
Query: 120 ----SSYEDSSLPSINALLQAEVLSRQITSPVSG------------INGDIRAKKIASIA 163
S +S S+ A S + +P+S I + AK A
Sbjct: 132 LDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDA 191
Query: 164 D---------------------------VCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
D + E+ L + V+WAK +P F LP DQV
Sbjct: 192 DENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVI 251
Query: 197 LLRAHAGEHLLLGATKRSMVFKDV-LLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQ 255
LL E LLGA + S+ LL + ++ + R+L E + F+
Sbjct: 252 LLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFR 311
Query: 256 ELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGEL 315
L +D E+A +KA++ F P+ +GL DP ++ L+ Q QV L + RFG+L
Sbjct: 312 ALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKL 371
Query: 316 LLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEM 351
LLLLP+L+ IT + IE + F K G ++ LL +M
Sbjct: 372 LLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDM 407
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 178 bits (452), Expect = 8e-45
Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)
Query: 37 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
LC +CGD A+G HYG +SC+ CK FF+R+++ N YSC + +C + K +R C+ CR
Sbjct: 104 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 163
Query: 97 KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 147
KC + GM KE V Q + RI S Y + L +++S + +
Sbjct: 164 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 223
Query: 148 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 203
I + + I ++ +C+ +L+V++ WAK+IP F L L DQ++LL++
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283
Query: 204 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 263
E L+LG RS+ F+D L+ +DYI+ +LA + ++ IL +LV ++ ++++ E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 342
Query: 264 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 323
+ LKAI + D+ + D +++L+ + +L+DY + + R G++L+ LP L+
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402
Query: 324 SITWQMIEQIQFIKLFGMAKIDNLLQEML 352
+ + ++ IKL G + L EML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 178 bits (452), Expect = 8e-45
Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)
Query: 37 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
LC +CGD A+G HYG +SC+ CK FF+R+++ N YSC + +C + K +R C+ CR
Sbjct: 104 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 163
Query: 97 KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 147
KC + GM KE V Q + RI S Y + L +++S + +
Sbjct: 164 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 223
Query: 148 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 203
I + + I ++ +C+ +L+V++ WAK+IP F L L DQ++LL++
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283
Query: 204 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 263
E L+LG RS+ F+D L+ +DYI+ +LA + ++ IL +LV ++ ++++ E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 342
Query: 264 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 323
+ LKAI + D+ + D +++L+ + +L+DY + + R G++L+ LP L+
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402
Query: 324 SITWQMIEQIQFIKLFGMAKIDNLLQEML 352
+ + ++ IKL G + L EML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 178 bits (452), Expect = 8e-45
Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)
Query: 37 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
LC +CGD A+G HYG +SC+ CK FF+R+++ N YSC + +C + K +R C+ CR
Sbjct: 127 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 186
Query: 97 KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 147
KC + GM KE V Q + RI S Y + L +++S + +
Sbjct: 187 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 246
Query: 148 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 203
I + + I ++ +C+ +L+V++ WAK+IP F L L DQ++LL++
Sbjct: 247 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 306
Query: 204 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 263
E L+LG RS+ F+D L+ +DYI+ +LA + ++ IL +LV ++ ++++ E
Sbjct: 307 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 365
Query: 264 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 323
+ LKAI + D+ + D +++L+ + +L+DY + + R G++L+ LP L+
Sbjct: 366 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 425
Query: 324 SITWQMIEQIQFIKLFGMAKIDNLLQEML 352
+ + ++ IKL G + L EML
Sbjct: 426 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 454
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 178 bits (452), Expect = 8e-45
Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)
Query: 37 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
LC +CGD A+G HYG +SC+ CK FF+R+++ N YSC + +C + K +R C+ CR
Sbjct: 104 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 163
Query: 97 KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 147
KC + GM KE V Q + RI S Y + L +++S + +
Sbjct: 164 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 223
Query: 148 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 203
I + + I ++ +C+ +L+V++ WAK+IP F L L DQ++LL++
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283
Query: 204 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 263
E L+LG RS+ F+D L+ +DYI+ +LA + ++ IL +LV ++ ++++ E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 342
Query: 264 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 323
+ LKAI + D+ + D +++L+ + +L+DY + + R G++L+ LP L+
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402
Query: 324 SITWQMIEQIQFIKLFGMAKIDNLLQEML 352
+ + ++ IKL G + L EML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
>gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo
sapiens]
Length = 385
Score = 177 bits (450), Expect = 1e-44
Identities = 124/364 (34%), Positives = 178/364 (48%), Gaps = 50/364 (13%)
Query: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQ--CVVDKDKRNQCRYCRL 95
C +CGDR++GKHYG +CDGC GFF+RS+R+N Y C+ Q C VDK RNQCR CRL
Sbjct: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
Query: 96 KKCFRAGMKKEAVQNER-DRISTRR-----------------SSYEDSSLPS---INALL 134
KKC M K+AVQ+ER R ST R + + ++LP+ A+
Sbjct: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
Query: 135 QAE----VLSRQITSP---------------VSGINGDIRAKKIASIADVCESMKEQLLV 175
Q E L+ T+P +NG + VCES L +
Sbjct: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
Query: 176 LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM-VFKDVLLLGNDYIVPRHCP 234
++WAK +PAF L L DQ+ LL E +LG + ++ V + LL +
Sbjct: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
Query: 235 ELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFF-------DPDAKGLSDPGKIK 287
+ I+ L E+V F++L++D E+A LK I+ F + + + I
Sbjct: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315
Query: 288 RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 347
L+ + Q++L YI+ R RFG+LLLLLP L+SI+ IE++ F K G I L
Sbjct: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375
Query: 348 LQEM 351
L +M
Sbjct: 376 LSDM 379
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 169 bits (427), Expect = 6e-42
Identities = 112/373 (30%), Positives = 187/373 (50%), Gaps = 31/373 (8%)
Query: 14 SSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYS 73
SS + PS + L P V C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+
Sbjct: 60 SSEELVPSPPSPLPPPR---VYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYT 116
Query: 74 CRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL 133
C + CV++K RN+C+YCRL+KCF GM KE+V+N+R++ S E + + A
Sbjct: 117 CHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAE 176
Query: 134 LQ--AEVLSR----------QITSPVSGINGDIRAKKIASIADVCESMKEQLLV-LVEWA 180
L E + + Q+ + + D R + + D + + ++ +VE+A
Sbjct: 177 LDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFA 236
Query: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240
K +P F L + DQ+ LL+A + L+L R +D + + + R +M
Sbjct: 237 KRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR-----TQMH 291
Query: 241 RVSIRILDELVLPFQE----LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVS 296
L +LV F L++DD E L AI D + L +P K+ +L+ + +
Sbjct: 292 NAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEA 351
Query: 297 LEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGS 356
L+ YI R+ F ++L+ + L+SI+ + E++ +K+ + L+QEML
Sbjct: 352 LKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEML---- 407
Query: 357 PSDAPHAHHPLHP 369
+ H PL P
Sbjct: 408 --ENSEGHEPLTP 418
>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
Length = 423
Score = 162 bits (409), Expect = 7e-40
Identities = 102/346 (29%), Positives = 169/346 (48%), Gaps = 35/346 (10%)
Query: 37 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
LC +CGD A+G HYG +SC+ CK FF+R+++ + YSC S +C + K +R C+ CR
Sbjct: 78 LCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFT 137
Query: 97 KCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL----------LQAEVLSRQITSP 146
KC R GM KE V+ DR+ R Y+ P ++ L L R+ +P
Sbjct: 138 KCLRVGMLKEGVR--LDRVRGGRQKYK--RRPEVDPLPFPGPFPAGPLAVAGGPRKTAAP 193
Query: 147 VSGINGDIRAKK----------------IASIADVCESMKEQLLVLVEWAKYIPAFCELP 190
V+ + + + + ++A +C+ +++V + WAK IP F L
Sbjct: 194 VNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLS 253
Query: 191 LDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDEL 250
L DQ+++L++ E L+LG +RS+ +D L D ++ A + + +L +L
Sbjct: 254 LSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALL-QL 312
Query: 251 VLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRG 310
V Q L+++ EY LKA+ + D+ + D +++LR + +L +Y R G
Sbjct: 313 VRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGG 372
Query: 311 ----RFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
R G LLL LP L+ +++ +KL G + L EML
Sbjct: 373 AERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEML 418
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 161 bits (407), Expect = 1e-39
Identities = 97/332 (29%), Positives = 171/332 (51%), Gaps = 22/332 (6%)
Query: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+C + C+++K RN+C+YCRL+K
Sbjct: 88 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 147
Query: 98 CFRAGMKKEAVQNERDR----ISTRRSSYEDSSLPSINALLQAEVLSRQITSPV-----S 148
CF GM KE+V+N+R++ + S + P + L++ + Q T P
Sbjct: 148 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 207
Query: 149 GINGDIRAKKIASIADVCESMKEQ----LLVLVEWAKYIPAFCELPLDDQVALLRAHAGE 204
+ ++++ D+ + E ++ VE+AK +P F L + DQ+ LL+A +
Sbjct: 208 YTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 267
Query: 205 HLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE----LQID 260
L+L R +D + + + R +M L +LV F L++D
Sbjct: 268 ILILRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFANQLLPLEMD 322
Query: 261 DNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLP 320
D E L AI D + L P ++ L+ + +L+ Y+ R+ F ++L+ +
Sbjct: 323 DAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT 382
Query: 321 TLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
L+SI+ + E++ +K+ + L+QEML
Sbjct: 383 DLRSISAKGAERVITLKMEIPGSMPPLIQEML 414
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 161 bits (407), Expect = 1e-39
Identities = 97/332 (29%), Positives = 171/332 (51%), Gaps = 22/332 (6%)
Query: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+C + C+++K RN+C+YCRL+K
Sbjct: 83 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 142
Query: 98 CFRAGMKKEAVQNERDR----ISTRRSSYEDSSLPSINALLQAEVLSRQITSPV-----S 148
CF GM KE+V+N+R++ + S + P + L++ + Q T P
Sbjct: 143 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 202
Query: 149 GINGDIRAKKIASIADVCESMKEQ----LLVLVEWAKYIPAFCELPLDDQVALLRAHAGE 204
+ ++++ D+ + E ++ VE+AK +P F L + DQ+ LL+A +
Sbjct: 203 YTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 262
Query: 205 HLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE----LQID 260
L+L R +D + + + R +M L +LV F L++D
Sbjct: 263 ILILRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFANQLLPLEMD 317
Query: 261 DNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLP 320
D E L AI D + L P ++ L+ + +L+ Y+ R+ F ++L+ +
Sbjct: 318 DAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT 377
Query: 321 TLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
L+SI+ + E++ +K+ + L+QEML
Sbjct: 378 DLRSISAKGAERVITLKMEIPGSMPPLIQEML 409
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 161 bits (407), Expect = 1e-39
Identities = 97/332 (29%), Positives = 171/332 (51%), Gaps = 22/332 (6%)
Query: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+C + C+++K RN+C+YCRL+K
Sbjct: 88 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 147
Query: 98 CFRAGMKKEAVQNERDR----ISTRRSSYEDSSLPSINALLQAEVLSRQITSPV-----S 148
CF GM KE+V+N+R++ + S + P + L++ + Q T P
Sbjct: 148 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 207
Query: 149 GINGDIRAKKIASIADVCESMKEQ----LLVLVEWAKYIPAFCELPLDDQVALLRAHAGE 204
+ ++++ D+ + E ++ VE+AK +P F L + DQ+ LL+A +
Sbjct: 208 YTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 267
Query: 205 HLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE----LQID 260
L+L R +D + + + R +M L +LV F L++D
Sbjct: 268 ILILRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFANQLLPLEMD 322
Query: 261 DNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLP 320
D E L AI D + L P ++ L+ + +L+ Y+ R+ F ++L+ +
Sbjct: 323 DAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT 382
Query: 321 TLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
L+SI+ + E++ +K+ + L+QEML
Sbjct: 383 DLRSISAKGAERVITLKMEIPGSMPPLIQEML 414
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 160 bits (404), Expect = 3e-39
Identities = 105/356 (29%), Positives = 174/356 (48%), Gaps = 26/356 (7%)
Query: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
C +C D+++G HYG SSC+GCKGFFRRS++KN +Y+C + C+++K RN+C+YCRL+K
Sbjct: 79 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 138
Query: 98 CFRAGMKKEAVQNERDRISTR------RSSYEDSSLPSINALLQAEVLSRQITSP----- 146
CF GM KEAV+N+R++ SYE S P + L+ + Q T P
Sbjct: 139 CFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELS--PQLEELITKVSKAHQETFPSLCQL 196
Query: 147 ---VSGINGDIRAKKIASIADVCESMKEQLLV-LVEWAKYIPAFCELPLDDQVALLRAHA 202
+ + D R + + D + + ++ +VE+AK +P F L + DQ+ LL+A
Sbjct: 197 GKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAAC 256
Query: 203 GEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQ----ELQ 258
+ L+L R +D + + + R +M L +LV F L+
Sbjct: 257 LDILMLRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFAGQLLPLE 311
Query: 259 IDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLL 318
+DD E L AI D L +P K+ +L+ + +L Y R+ F +L+
Sbjct: 312 MDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMK 371
Query: 319 LPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQE 374
+ L+ I+ + E+ +K+ + L++EML + + HP+ E
Sbjct: 372 ITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSE 427
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 160 bits (404), Expect = 3e-39
Identities = 105/356 (29%), Positives = 174/356 (48%), Gaps = 26/356 (7%)
Query: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
C +C D+++G HYG SSC+GCKGFFRRS++KN +Y+C + C+++K RN+C+YCRL+K
Sbjct: 90 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 149
Query: 98 CFRAGMKKEAVQNERDRISTR------RSSYEDSSLPSINALLQAEVLSRQITSP----- 146
CF GM KEAV+N+R++ SYE S P + L+ + Q T P
Sbjct: 150 CFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELS--PQLEELITKVSKAHQETFPSLCQL 207
Query: 147 ---VSGINGDIRAKKIASIADVCESMKEQLLV-LVEWAKYIPAFCELPLDDQVALLRAHA 202
+ + D R + + D + + ++ +VE+AK +P F L + DQ+ LL+A
Sbjct: 208 GKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAAC 267
Query: 203 GEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQ----ELQ 258
+ L+L R +D + + + R +M L +LV F L+
Sbjct: 268 LDILMLRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFAGQLLPLE 322
Query: 259 IDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLL 318
+DD E L AI D L +P K+ +L+ + +L Y R+ F +L+
Sbjct: 323 MDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMK 382
Query: 319 LPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQE 374
+ L+ I+ + E+ +K+ + L++EML + + HP+ E
Sbjct: 383 ITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSE 438
>gi|7706515 photoreceptor-specific nuclear receptor isoform a [Homo
sapiens]
Length = 367
Score = 155 bits (393), Expect = 5e-38
Identities = 110/345 (31%), Positives = 159/345 (46%), Gaps = 47/345 (13%)
Query: 3 SVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFF 62
+V A A +S SP P + S C +CGD ++GKHYG +C+GC GFF
Sbjct: 12 TVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFF 71
Query: 63 RRSVRKNHMYSCRF-SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRR-- 119
+RSVR+ +Y C+ + C VDK RNQC+ CRLKKC +AGM ++AVQNER ST +
Sbjct: 72 KRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVH 131
Query: 120 ----SSYEDSSLPSINALLQAEVLSRQITSPVSG------------INGDIRAKKIASIA 163
S +S S+ A S + +P+S I + AK A
Sbjct: 132 LDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDA 191
Query: 164 D---------------------------VCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
D + E+ L + V+WAK +P F LP DQV
Sbjct: 192 DENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVI 251
Query: 197 LLRAHAGEHLLLGATKRSMVFKDV-LLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQ 255
LL E LLGA + S+ LL + ++ + R+L E + F+
Sbjct: 252 LLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFR 311
Query: 256 ELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300
L +D E+A +KA++ F P+ +GL DP ++ L+ Q QV L +
Sbjct: 312 ALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQH 356
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 145 bits (366), Expect = 7e-35
Identities = 104/368 (28%), Positives = 183/368 (49%), Gaps = 36/368 (9%)
Query: 12 VESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHM 71
+++ + PS G+ N LCA+CGD A +HYG +C+GCKGFF+R+V+KN
Sbjct: 244 LDTQVPSPPSRGSPSN-------EGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAK 296
Query: 72 YSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNE-----RDRISTRRSSYEDSS 126
Y C ++ C VDK +RN+C+YCR +KC GM KE V+ + R R+ ++ S ++ S
Sbjct: 297 YVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPS 356
Query: 127 LPS-----INALLQAEV----------LSRQITSPVSGINGDIRAKKIASIADVCESMKE 171
PS I+AL++A V SR +P ++GD + I D+ E
Sbjct: 357 PPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGD-DTQHIQQFYDLLTGSME 415
Query: 172 QLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPR 231
++ WA+ IP F +LP DQ L + E +L RS + L+ N ++
Sbjct: 416 ---IIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVL-- 470
Query: 232 HCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRS 291
H + I + E Q + ID + ++ + A+ + GL +P +++ L++
Sbjct: 471 HRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMV-TERHGLKEPKRVEELQN 529
Query: 292 QVQVSLEDYI--NDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQ 349
++ L+D++ N+ + +LL LP L+++ Q +++I ++KL + ++
Sbjct: 530 KIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIID 589
Query: 350 EMLLGGSP 357
++ L P
Sbjct: 590 KLFLDTLP 597
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 144 bits (364), Expect = 1e-34
Identities = 99/335 (29%), Positives = 158/335 (47%), Gaps = 39/335 (11%)
Query: 29 PNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKN--HMYSCRFSRQCVVDKDK 86
P+ L LC +CGD+ATG HY +C+GCKGFFRR+++KN YSC++ +CV+DK
Sbjct: 98 PSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVT 157
Query: 87 RNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA---------- 136
RNQC+ CR KKC GM + V ++ R++ R+ E+ L ++
Sbjct: 158 RNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDE 217
Query: 137 ------EVLSRQITSPVSGINGDIRAKKI------ASIADVCESMKEQLLV--------- 175
V + + G + + K + A I + E K L
Sbjct: 218 EWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIIT 277
Query: 176 -----LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVP 230
+V++AK +P FCELP +DQ+ LL+ E + L A R + L L + V
Sbjct: 278 PAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVT 337
Query: 231 RHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLR 290
R + + VS I D L + +DD E A L+A++ D GL+ +I++ +
Sbjct: 338 RGQLKNGGLGVVSDAIFD-LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQ 396
Query: 291 SQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 325
++ E YIN R++ + +LL+ + L+ I
Sbjct: 397 DSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMI 431
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,933,659
Number of Sequences: 37866
Number of extensions: 867289
Number of successful extensions: 4211
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 121
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 3835
Number of HSP's gapped (non-prelim): 270
length of query: 442
length of database: 18,247,518
effective HSP length: 105
effective length of query: 337
effective length of database: 14,271,588
effective search space: 4809525156
effective search space used: 4809525156
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.