Guide to the Human Genome
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Search of human proteins with 71725336

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
sapiens]
         (395 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa...   793   0.0  
gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo sa...   763   0.0  
gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo sa...   711   0.0  
gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo sa...   711   0.0  
gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo sa...   681   0.0  
gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo sa...   681   0.0  
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]        551   e-157
gi|4506755 retinoid X receptor, alpha [Homo sapiens]                  267   1e-71
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]        261   6e-70
gi|11415052 retinoid X receptor, beta [Homo sapiens]                  260   2e-69
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom...   226   4e-59
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof...   220   2e-57
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo...   216   2e-56
gi|7657395 photoreceptor-specific nuclear receptor isoform b [Ho...   184   9e-47
gi|238550159 estrogen-related receptor beta [Homo sapiens]            182   4e-46
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi...   178   7e-45
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi...   178   7e-45
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi...   178   7e-45
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap...   178   7e-45
gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo...   177   1e-44
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]     166   3e-41
gi|18860920 estrogen-related receptor alpha [Homo sapiens]            162   6e-40
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]   161   1e-39
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]    161   1e-39
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]     161   1e-39
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]   159   4e-39
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]     159   4e-39
gi|7706515 photoreceptor-specific nuclear receptor isoform a [Ho...   155   5e-38
gi|189491771 thyroid hormone receptor, beta [Homo sapiens]            144   1e-34
gi|189491769 thyroid hormone receptor, beta [Homo sapiens]            144   1e-34

>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
           sapiens]
          Length = 395

 Score =  793 bits (2048), Expect = 0.0
 Identities = 395/395 (100%), Positives = 395/395 (100%)

Query: 1   MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG 60
           MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG
Sbjct: 1   MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG 60

Query: 61  FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS 120
           FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS
Sbjct: 61  FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS 120

Query: 121 SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA 180
           SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA
Sbjct: 121 SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA 180

Query: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240
           KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS
Sbjct: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240

Query: 241 RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300
           RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY
Sbjct: 241 RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300

Query: 301 INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQ 360
           INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQ
Sbjct: 301 INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQ 360

Query: 361 EGRGWSGDSPGDRPHTVSSPLSSLASPLCRFGQVA 395
           EGRGWSGDSPGDRPHTVSSPLSSLASPLCRFGQVA
Sbjct: 361 EGRGWSGDSPGDRPHTVSSPLSSLASPLCRFGQVA 395


>gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo
           sapiens]
          Length = 417

 Score =  763 bits (1969), Expect = 0.0
 Identities = 379/379 (100%), Positives = 379/379 (100%)

Query: 17  DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 76
           DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF
Sbjct: 39  DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 98

Query: 77  SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 136
           SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA
Sbjct: 99  SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 158

Query: 137 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
           EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA
Sbjct: 159 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 218

Query: 197 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 256
           LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE
Sbjct: 219 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 278

Query: 257 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 316
           LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL
Sbjct: 279 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 338

Query: 317 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPGDRPHT 376
           LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPGDRPHT
Sbjct: 339 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPGDRPHT 398

Query: 377 VSSPLSSLASPLCRFGQVA 395
           VSSPLSSLASPLCRFGQVA
Sbjct: 399 VSSPLSSLASPLCRFGQVA 417


>gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
           sapiens]
          Length = 442

 Score =  711 bits (1835), Expect = 0.0
 Identities = 360/375 (96%), Positives = 360/375 (96%), Gaps = 13/375 (3%)

Query: 1   MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG 60
           MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG
Sbjct: 1   MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG 60

Query: 61  FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS 120
           FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS
Sbjct: 61  FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS 120

Query: 121 SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA 180
           SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA
Sbjct: 121 SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA 180

Query: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240
           KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS
Sbjct: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240

Query: 241 RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300
           RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY
Sbjct: 241 RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300

Query: 301 INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQ 360
           INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG     
Sbjct: 301 INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG----- 355

Query: 361 EGRGWSGDSPGDRPH 375
                   SP D PH
Sbjct: 356 --------SPSDAPH 362


>gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo
           sapiens]
          Length = 452

 Score =  711 bits (1835), Expect = 0.0
 Identities = 360/375 (96%), Positives = 360/375 (96%), Gaps = 13/375 (3%)

Query: 1   MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG 60
           MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG
Sbjct: 1   MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKG 60

Query: 61  FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS 120
           FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS
Sbjct: 61  FFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRS 120

Query: 121 SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA 180
           SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA
Sbjct: 121 SYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWA 180

Query: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240
           KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS
Sbjct: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240

Query: 241 RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300
           RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY
Sbjct: 241 RVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300

Query: 301 INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQ 360
           INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG     
Sbjct: 301 INDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG----- 355

Query: 361 EGRGWSGDSPGDRPH 375
                   SP D PH
Sbjct: 356 --------SPSDAPH 362


>gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo
           sapiens]
          Length = 464

 Score =  681 bits (1756), Expect = 0.0
 Identities = 344/359 (95%), Positives = 344/359 (95%), Gaps = 13/359 (3%)

Query: 17  DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 76
           DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF
Sbjct: 39  DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 98

Query: 77  SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 136
           SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA
Sbjct: 99  SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 158

Query: 137 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
           EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA
Sbjct: 159 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 218

Query: 197 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 256
           LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE
Sbjct: 219 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 278

Query: 257 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 316
           LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL
Sbjct: 279 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 338

Query: 317 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPGDRPH 375
           LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG             SP D PH
Sbjct: 339 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG-------------SPSDAPH 384


>gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
           sapiens]
          Length = 474

 Score =  681 bits (1756), Expect = 0.0
 Identities = 344/359 (95%), Positives = 344/359 (95%), Gaps = 13/359 (3%)

Query: 17  DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 76
           DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF
Sbjct: 39  DTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF 98

Query: 77  SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 136
           SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA
Sbjct: 99  SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA 158

Query: 137 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
           EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA
Sbjct: 159 EVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 218

Query: 197 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 256
           LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE
Sbjct: 219 LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE 278

Query: 257 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 316
           LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL
Sbjct: 279 LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELL 338

Query: 317 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPGDRPH 375
           LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG             SP D PH
Sbjct: 339 LLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG-------------SPSDAPH 384


>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
          Length = 445

 Score =  551 bits (1419), Expect = e-157
 Identities = 274/342 (80%), Positives = 309/342 (90%), Gaps = 3/342 (0%)

Query: 14  SSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYS 73
           +S D+S  E T++N  ++ GV+ LCAICGDRATGKHYGASSCDGCKGFFRRS+RK+H+YS
Sbjct: 27  NSSDSSAPE-TSMNTTDN-GVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYS 84

Query: 74  CRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL 133
           CRFSRQCVVDKDKRNQCRYCRL+KCFRAGMKKEAVQNERDRISTRRS+++ S++PSIN L
Sbjct: 85  CRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTL 144

Query: 134 LQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDD 193
            QAEV SRQI+    G + DI  KKIASI DVCESMK+QLLVLVEWAKYIPAFCELPLDD
Sbjct: 145 AQAEVRSRQISVSSPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDD 204

Query: 194 QVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLP 253
           QVALLRAHAGEHLLLGATKRSM++KD+LLLGN+Y++ R+  E+ E+SRV+ R+LDELV P
Sbjct: 205 QVALLRAHAGEHLLLGATKRSMMYKDILLLGNNYVIHRNSCEV-EISRVANRVLDELVRP 263

Query: 254 FQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFG 313
           FQE+QIDDNEYA LKAI+FFDPDAKGLSDP KIK +R QVQ+ LEDYINDRQYDSRGRFG
Sbjct: 264 FQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFG 323

Query: 314 ELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG 355
           ELLLLLPTLQSITWQMIEQIQF+KLFGM KIDNLLQEMLLGG
Sbjct: 324 ELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLGG 365


>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
          Length = 462

 Score =  267 bits (682), Expect = 1e-71
 Identities = 150/356 (42%), Positives = 211/356 (59%), Gaps = 14/356 (3%)

Query: 11  PVESSYDTSPSEGTN--LNAP-NSLGVSA-----LCAICGDRATGKHYGASSCDGCKGFF 62
           PV SS D  P  G N  L  P +  G  A     +CAICGDR++GKHYG  SC+GCKGFF
Sbjct: 100 PVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFF 159

Query: 63  RRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSY 122
           +R+VRK+  Y+CR ++ C++DK +RN+C+YCR +KC   GMK+EAVQ ER R   R  + 
Sbjct: 160 KRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENE 219

Query: 123 EDSSLPS-----INALLQAEVLSRQITSPVSGINGDIRAKKIAS-IADVCESMKEQLLVL 176
            +S+  +     +  +L+AE+     T      N  +        + ++C++  +QL  L
Sbjct: 220 VESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTL 279

Query: 177 VEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPEL 236
           VEWAK IP F ELPLDDQV LLRA   E L+   + RS+  KD +LL     V R+    
Sbjct: 280 VEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHS 339

Query: 237 AEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVS 296
           A +  +  R+L ELV   +++Q+D  E   L+AI+ F+PD+KGLS+P +++ LR +V  S
Sbjct: 340 AGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYAS 399

Query: 297 LEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
           LE Y   +  +  GRF +LLL LP L+SI  + +E + F KL G   ID  L EML
Sbjct: 400 LEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 455


>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
          Length = 463

 Score =  261 bits (668), Expect = 6e-70
 Identities = 142/351 (40%), Positives = 210/351 (59%), Gaps = 10/351 (2%)

Query: 12  VESSYDTSPSEGT----NLNAPNSLG---VSALCAICGDRATGKHYGASSCDGCKGFFRR 64
           V SS D  P  G     N+N P++     V  +CAICGDR++GKHYG  SC+GCKGFF+R
Sbjct: 106 VSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKR 165

Query: 65  SVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED 124
           ++RK+ +Y+CR ++ C++DK +RN+C+YCR +KC   GMK+EAVQ ER R   R  S  +
Sbjct: 166 TIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAE 225

Query: 125 SSLPSINALLQAEVLSRQIT-SPVSGINGDIRAKKIAS--IADVCESMKEQLLVLVEWAK 181
            +      +    +L  ++   P +   GD+  +   +  + ++C +  +QL  LVEWAK
Sbjct: 226 CATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAK 285

Query: 182 YIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSR 241
            IP F +L L+DQV LLRA   E L+   + RS+  +D +LL     V R     A +  
Sbjct: 286 RIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGS 345

Query: 242 VSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYI 301
           +  R+L ELV   +++Q+D +E   L+AI+ F+PDAKGLS+P +++ LR +V  +LE Y 
Sbjct: 346 IFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYT 405

Query: 302 NDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
             +  +  GRF +LLL LP L+SI  + +E + F KL G   ID  L EML
Sbjct: 406 KQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 456


>gi|11415052 retinoid X receptor, beta [Homo sapiens]
          Length = 533

 Score =  260 bits (664), Expect = 2e-69
 Identities = 141/326 (43%), Positives = 200/326 (61%), Gaps = 13/326 (3%)

Query: 37  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
           LCAICGDR++GKHYG  SC+GCKGFF+R++RK+  YSCR ++ C VDK +RN+C+YCR +
Sbjct: 204 LCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQ 263

Query: 97  KCFRAGMKKEAVQNERDRISTRRSSYEDSS-----LPSINALLQAEVLSRQ-----ITSP 146
           KC   GMK+EAVQ ER R   +    E +      +P ++ +L+AE+   Q     +  P
Sbjct: 264 KCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP-VDRILEAELAVEQKSDQGVEGP 322

Query: 147 VSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL 206
             G  G   +     + ++C++  +QL  LVEWAK IP F  LPLDDQV LLRA   E L
Sbjct: 323 --GGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELL 380

Query: 207 LLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAY 266
           +   + RS+  +D +LL     V R+    A +  +  R+L ELV   +++++D  E   
Sbjct: 381 IASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGC 440

Query: 267 LKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSIT 326
           L+AII F+PDAKGLS+P +++ LR +V  SLE Y   +  + +GRF +LLL LP L+SI 
Sbjct: 441 LRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIG 500

Query: 327 WQMIEQIQFIKLFGMAKIDNLLQEML 352
            + +E + F KL G   ID  L EML
Sbjct: 501 LKCLEHLFFFKLIGDTPIDTFLMEML 526


>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
           sapiens]
          Length = 404

 Score =  226 bits (575), Expect = 4e-59
 Identities = 133/346 (38%), Positives = 187/346 (54%), Gaps = 26/346 (7%)

Query: 33  GVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRY 92
           G+   C +CGD+++GKHYG  +C+GCK FF+RS+R+N  Y+CR +R C +D+  RNQC+Y
Sbjct: 51  GLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQY 110

Query: 93  CRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL-----------------LQ 135
           CRLKKCFR GM+KEAVQ  R   S   +    S  P  +AL                 L 
Sbjct: 111 CRLKKCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELI 170

Query: 136 AEVLSRQITSPVSGI--NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDD 193
           A++L  +     +G    G   A  +  I +VCE     L   VEWA++ P F ELP+ D
Sbjct: 171 AQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVAD 230

Query: 194 QVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDE 249
           QVALLR    E  +L A + ++      LL        H   +A    V+    +R   E
Sbjct: 231 QVALLRLSWSELFVLNAAQAALPLHTAPLLA---AAGLHAAPMAAERAVAFMDQVRAFQE 287

Query: 250 LVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSR 309
            V     LQ+D  EY  LKAI  F PDA GLSDP  ++ L+ + QV+L +Y+  +     
Sbjct: 288 QVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQP 347

Query: 310 GRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGG 355
            RFG LLL LP L+++   +I Q+ F++L G   I+ L+++MLL G
Sbjct: 348 QRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSG 393


>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
           a [Homo sapiens]
          Length = 414

 Score =  220 bits (561), Expect = 2e-57
 Identities = 127/330 (38%), Positives = 190/330 (57%), Gaps = 17/330 (5%)

Query: 38  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
           C +CGD+++GKHYG  +C+GCK FF+RSVR+N  Y+CR +R C +D+  RNQC+YCRLKK
Sbjct: 79  CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138

Query: 98  CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQIT-------SPVSGI 150
           C + GM++EAVQ  R R+   + ++   +L + + L     LS  I+        P S  
Sbjct: 139 CLKVGMRREAVQ--RGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRF 196

Query: 151 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 209
               ++   I  I ++CE     L   VEWA+ IP F +L + DQVALLR    E  +L 
Sbjct: 197 GSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLN 256

Query: 210 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 265
           A + SM      LL        H   ++    V+    IRI  E V   + L +D  EY+
Sbjct: 257 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 313

Query: 266 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 325
            LKAI+ F  DA GLSD   ++ L+ + Q +LE+Y+  +  +   RFG+LLL LP+L+++
Sbjct: 314 CLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTV 373

Query: 326 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGG 355
           +  +IEQ+ F++L G   I+ L+++MLL G
Sbjct: 374 SSSVIEQLFFVRLVGKTPIETLIRDMLLSG 403


>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
           sapiens]
          Length = 423

 Score =  216 bits (551), Expect = 2e-56
 Identities = 126/330 (38%), Positives = 188/330 (56%), Gaps = 17/330 (5%)

Query: 38  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
           C +CGD+++GKHYG  +C+GCK FF+RSVR+N  Y+CR +R C +D+  RNQC+YCRLKK
Sbjct: 86  CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145

Query: 98  CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALL-------QAEVLSRQITSPVSGI 150
           C + GM++EAVQ  R R+   + +    +L + + L           +L R    P S  
Sbjct: 146 CLKVGMRREAVQ--RGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRY 203

Query: 151 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 209
               ++   I  I ++CE     L   VEWA+ IP F +L + DQV+LLR    E  +L 
Sbjct: 204 GSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLN 263

Query: 210 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 265
           A + SM      LL        H   ++    V+    IRI  E V   + L +D  EY+
Sbjct: 264 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 320

Query: 266 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 325
            LKAI+ F  DA GLSD   I+ L+ + Q +LE+Y+  +  +   RFG+LLL LP+L+++
Sbjct: 321 CLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380

Query: 326 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGG 355
           +  +IEQ+ F++L G   I+ L+++MLL G
Sbjct: 381 SSSVIEQLFFVRLVGKTPIETLIRDMLLSG 410


>gi|7657395 photoreceptor-specific nuclear receptor isoform b [Homo
           sapiens]
          Length = 410

 Score =  184 bits (468), Expect = 9e-47
 Identities = 130/396 (32%), Positives = 187/396 (47%), Gaps = 47/396 (11%)

Query: 3   SVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFF 62
           +V A   A   +S   SP        P  +  S  C +CGD ++GKHYG  +C+GC GFF
Sbjct: 12  TVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFF 71

Query: 63  RRSVRKNHMYSCRF-SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRR-- 119
           +RSVR+  +Y C+  +  C VDK  RNQC+ CRLKKC +AGM ++AVQNER   ST +  
Sbjct: 72  KRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVH 131

Query: 120 ----SSYEDSSLPSINALLQAEVLSRQITSPVSG------------INGDIRAKKIASIA 163
                S  +S   S+ A       S +  +P+S             I  +  AK     A
Sbjct: 132 LDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDA 191

Query: 164 D---------------------------VCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
           D                           + E+    L + V+WAK +P F  LP  DQV 
Sbjct: 192 DENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVI 251

Query: 197 LLRAHAGEHLLLGATKRSMVFKDV-LLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQ 255
           LL     E  LLGA + S+      LL   +            ++ +  R+L E +  F+
Sbjct: 252 LLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFR 311

Query: 256 ELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGEL 315
            L +D  E+A +KA++ F P+ +GL DP  ++ L+ Q QV L  +          RFG+L
Sbjct: 312 ALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKL 371

Query: 316 LLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEM 351
           LLLLP+L+ IT + IE + F K  G   ++ LL +M
Sbjct: 372 LLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDM 407


>gi|238550159 estrogen-related receptor beta [Homo sapiens]
          Length = 508

 Score =  182 bits (463), Expect = 4e-46
 Identities = 124/403 (30%), Positives = 198/403 (49%), Gaps = 37/403 (9%)

Query: 9   GAPVESSYDTSPS---EGTNLNAPNSLGV--SALCAICGDRATGKHYGASSCDGCKGFFR 63
           G P   SY+   S   E + +     L      LC +CGD A+G HYG +SC+ CK FF+
Sbjct: 69  GTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFK 128

Query: 64  RSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRIS----TRR 119
           R+++ N  YSC  + +C + K +R  C+ CR  KC + GM KE V+ +R R       RR
Sbjct: 129 RTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRR 188

Query: 120 SSYEDSSLPS--------------INALLQAEVLSRQITSPVSGINGDIRAKKIASIADV 165
              E S   S              ++ LL AE        P     GDI+A     +  +
Sbjct: 189 LDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKA-----LTTL 243

Query: 166 CESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGN 225
           C+    +L+V++ WAK+IP F  L L DQ++LL++   E L+LG   RS+ + D L+   
Sbjct: 244 CDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAE 303

Query: 226 DYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGK 285
           DYI+      LA +  +   IL +LV  +++L+++  E+  LKA+   + D+  + D   
Sbjct: 304 DYIMDEEHSRLAGLLELYRAIL-QLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEA 362

Query: 286 IKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKID 345
           +++L+  +  +L+DY   ++++   R G+LLL LP L+    + ++    +KL G   + 
Sbjct: 363 VQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMH 422

Query: 346 NLLQEMLLGGPCQAQEGRGWSGDSPGDR---PHTVSSPLSSLA 385
            L  EML     +A+ G+     SP D     H    P  S A
Sbjct: 423 KLFLEML-----EAKVGQEQLRGSPKDERMSSHDGKCPFQSAA 460


>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
           sapiens]
          Length = 435

 Score =  178 bits (452), Expect = 7e-45
 Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)

Query: 37  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
           LC +CGD A+G HYG +SC+ CK FF+R+++ N  YSC  + +C + K +R  C+ CR  
Sbjct: 104 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 163

Query: 97  KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 147
           KC + GM KE V         Q  + RI    S Y +  L         +++S  + +  
Sbjct: 164 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 223

Query: 148 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 203
             I    +  +    I ++  +C+    +L+V++ WAK+IP F  L L DQ++LL++   
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283

Query: 204 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 263
           E L+LG   RS+ F+D L+  +DYI+     +LA +  ++  IL +LV  ++ ++++  E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 342

Query: 264 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 323
           +  LKAI   + D+  + D   +++L+  +  +L+DY   +  +   R G++L+ LP L+
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402

Query: 324 SITWQMIEQIQFIKLFGMAKIDNLLQEML 352
             + + ++    IKL G   +  L  EML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431


>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
           sapiens]
          Length = 435

 Score =  178 bits (452), Expect = 7e-45
 Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)

Query: 37  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
           LC +CGD A+G HYG +SC+ CK FF+R+++ N  YSC  + +C + K +R  C+ CR  
Sbjct: 104 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 163

Query: 97  KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 147
           KC + GM KE V         Q  + RI    S Y +  L         +++S  + +  
Sbjct: 164 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 223

Query: 148 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 203
             I    +  +    I ++  +C+    +L+V++ WAK+IP F  L L DQ++LL++   
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283

Query: 204 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 263
           E L+LG   RS+ F+D L+  +DYI+     +LA +  ++  IL +LV  ++ ++++  E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 342

Query: 264 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 323
           +  LKAI   + D+  + D   +++L+  +  +L+DY   +  +   R G++L+ LP L+
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402

Query: 324 SITWQMIEQIQFIKLFGMAKIDNLLQEML 352
             + + ++    IKL G   +  L  EML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431


>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
           sapiens]
          Length = 458

 Score =  178 bits (452), Expect = 7e-45
 Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)

Query: 37  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
           LC +CGD A+G HYG +SC+ CK FF+R+++ N  YSC  + +C + K +R  C+ CR  
Sbjct: 127 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 186

Query: 97  KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 147
           KC + GM KE V         Q  + RI    S Y +  L         +++S  + +  
Sbjct: 187 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 246

Query: 148 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 203
             I    +  +    I ++  +C+    +L+V++ WAK+IP F  L L DQ++LL++   
Sbjct: 247 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 306

Query: 204 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 263
           E L+LG   RS+ F+D L+  +DYI+     +LA +  ++  IL +LV  ++ ++++  E
Sbjct: 307 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 365

Query: 264 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 323
           +  LKAI   + D+  + D   +++L+  +  +L+DY   +  +   R G++L+ LP L+
Sbjct: 366 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 425

Query: 324 SITWQMIEQIQFIKLFGMAKIDNLLQEML 352
             + + ++    IKL G   +  L  EML
Sbjct: 426 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 454


>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
           sapiens]
          Length = 435

 Score =  178 bits (452), Expect = 7e-45
 Identities = 101/329 (30%), Positives = 176/329 (53%), Gaps = 14/329 (4%)

Query: 37  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
           LC +CGD A+G HYG +SC+ CK FF+R+++ N  YSC  + +C + K +R  C+ CR  
Sbjct: 104 LCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFM 163

Query: 97  KCFRAGMKKEAV---------QNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPV 147
           KC + GM KE V         Q  + RI    S Y +  L         +++S  + +  
Sbjct: 164 KCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEP 223

Query: 148 SGI----NGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 203
             I    +  +    I ++  +C+    +L+V++ WAK+IP F  L L DQ++LL++   
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283

Query: 204 EHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNE 263
           E L+LG   RS+ F+D L+  +DYI+     +LA +  ++  IL +LV  ++ ++++  E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEE 342

Query: 264 YAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQ 323
           +  LKAI   + D+  + D   +++L+  +  +L+DY   +  +   R G++L+ LP L+
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402

Query: 324 SITWQMIEQIQFIKLFGMAKIDNLLQEML 352
             + + ++    IKL G   +  L  EML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431


>gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo
           sapiens]
          Length = 385

 Score =  177 bits (450), Expect = 1e-44
 Identities = 124/364 (34%), Positives = 178/364 (48%), Gaps = 50/364 (13%)

Query: 38  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQ--CVVDKDKRNQCRYCRL 95
           C +CGDR++GKHYG  +CDGC GFF+RS+R+N  Y C+   Q  C VDK  RNQCR CRL
Sbjct: 16  CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75

Query: 96  KKCFRAGMKKEAVQNER-DRISTRR-----------------SSYEDSSLPS---INALL 134
           KKC    M K+AVQ+ER  R ST R                 + +  ++LP+     A+ 
Sbjct: 76  KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135

Query: 135 QAE----VLSRQITSP---------------VSGINGDIRAKKIASIADVCESMKEQLLV 175
           Q E     L+   T+P                  +NG        +   VCES    L +
Sbjct: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195

Query: 176 LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM-VFKDVLLLGNDYIVPRHCP 234
            ++WAK +PAF  L L DQ+ LL     E  +LG  + ++ V  + LL  +         
Sbjct: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255

Query: 235 ELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFF-------DPDAKGLSDPGKIK 287
           +        I+ L E+V  F++L++D  E+A LK I+ F         + +   +   I 
Sbjct: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315

Query: 288 RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 347
            L+ + Q++L  YI+ R      RFG+LLLLLP L+SI+   IE++ F K  G   I  L
Sbjct: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375

Query: 348 LQEM 351
           L +M
Sbjct: 376 LSDM 379


>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
          Length = 448

 Score =  166 bits (421), Expect = 3e-41
 Identities = 108/356 (30%), Positives = 182/356 (51%), Gaps = 25/356 (7%)

Query: 14  SSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYS 73
           SS +  PS  + L  P    V   C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+
Sbjct: 60  SSEELVPSPPSPLPPPR---VYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYT 116

Query: 74  CRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL 133
           C   + CV++K  RN+C+YCRL+KCF  GM KE+V+N+R++     S  E +    + A 
Sbjct: 117 CHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAE 176

Query: 134 LQ--AEVLSR----------QITSPVSGINGDIRAKKIASIADVCESMKEQLLV-LVEWA 180
           L    E + +          Q+    +  + D R +    + D    +  + ++ +VE+A
Sbjct: 177 LDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFA 236

Query: 181 KYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMS 240
           K +P F  L + DQ+ LL+A   + L+L    R    +D +   +   + R      +M 
Sbjct: 237 KRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR-----TQMH 291

Query: 241 RVSIRILDELVLPFQE----LQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVS 296
                 L +LV  F      L++DD E   L AI     D + L +P K+ +L+  +  +
Sbjct: 292 NAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEA 351

Query: 297 LEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
           L+ YI  R+      F ++L+ +  L+SI+ +  E++  +K+     +  L+QEML
Sbjct: 352 LKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEML 407


>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
          Length = 423

 Score =  162 bits (409), Expect = 6e-40
 Identities = 102/346 (29%), Positives = 169/346 (48%), Gaps = 35/346 (10%)

Query: 37  LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
           LC +CGD A+G HYG +SC+ CK FF+R+++ +  YSC  S +C + K +R  C+ CR  
Sbjct: 78  LCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFT 137

Query: 97  KCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINAL----------LQAEVLSRQITSP 146
           KC R GM KE V+   DR+   R  Y+    P ++ L          L      R+  +P
Sbjct: 138 KCLRVGMLKEGVR--LDRVRGGRQKYK--RRPEVDPLPFPGPFPAGPLAVAGGPRKTAAP 193

Query: 147 VSGINGDIRAKK----------------IASIADVCESMKEQLLVLVEWAKYIPAFCELP 190
           V+ +   +   +                + ++A +C+    +++V + WAK IP F  L 
Sbjct: 194 VNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLS 253

Query: 191 LDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDEL 250
           L DQ+++L++   E L+LG  +RS+  +D L    D ++       A +  +   +L +L
Sbjct: 254 LSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALL-QL 312

Query: 251 VLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRG 310
           V   Q L+++  EY  LKA+   + D+  + D   +++LR  +  +L +Y   R     G
Sbjct: 313 VRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGG 372

Query: 311 ----RFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
               R G LLL LP L+    +++     +KL G   +  L  EML
Sbjct: 373 AERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEML 418


>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  161 bits (407), Expect = 1e-39
 Identities = 97/332 (29%), Positives = 171/332 (51%), Gaps = 22/332 (6%)

Query: 38  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
           C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+C   + C+++K  RN+C+YCRL+K
Sbjct: 88  CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 147

Query: 98  CFRAGMKKEAVQNERDR----ISTRRSSYEDSSLPSINALLQAEVLSRQITSPV-----S 148
           CF  GM KE+V+N+R++    +     S   +  P +  L++    + Q T P       
Sbjct: 148 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 207

Query: 149 GINGDIRAKKIASIADVCESMKEQ----LLVLVEWAKYIPAFCELPLDDQVALLRAHAGE 204
               +   ++++   D+ +   E     ++  VE+AK +P F  L + DQ+ LL+A   +
Sbjct: 208 YTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 267

Query: 205 HLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE----LQID 260
            L+L    R    +D +   +   + R      +M       L +LV  F      L++D
Sbjct: 268 ILILRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFANQLLPLEMD 322

Query: 261 DNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLP 320
           D E   L AI     D + L  P ++  L+  +  +L+ Y+  R+      F ++L+ + 
Sbjct: 323 DAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT 382

Query: 321 TLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
            L+SI+ +  E++  +K+     +  L+QEML
Sbjct: 383 DLRSISAKGAERVITLKMEIPGSMPPLIQEML 414


>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
          Length = 457

 Score =  161 bits (407), Expect = 1e-39
 Identities = 97/332 (29%), Positives = 171/332 (51%), Gaps = 22/332 (6%)

Query: 38  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
           C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+C   + C+++K  RN+C+YCRL+K
Sbjct: 83  CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 142

Query: 98  CFRAGMKKEAVQNERDR----ISTRRSSYEDSSLPSINALLQAEVLSRQITSPV-----S 148
           CF  GM KE+V+N+R++    +     S   +  P +  L++    + Q T P       
Sbjct: 143 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 202

Query: 149 GINGDIRAKKIASIADVCESMKEQ----LLVLVEWAKYIPAFCELPLDDQVALLRAHAGE 204
               +   ++++   D+ +   E     ++  VE+AK +P F  L + DQ+ LL+A   +
Sbjct: 203 YTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 262

Query: 205 HLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE----LQID 260
            L+L    R    +D +   +   + R      +M       L +LV  F      L++D
Sbjct: 263 ILILRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFANQLLPLEMD 317

Query: 261 DNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLP 320
           D E   L AI     D + L  P ++  L+  +  +L+ Y+  R+      F ++L+ + 
Sbjct: 318 DAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT 377

Query: 321 TLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
            L+SI+ +  E++  +K+     +  L+QEML
Sbjct: 378 DLRSISAKGAERVITLKMEIPGSMPPLIQEML 409


>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  161 bits (407), Expect = 1e-39
 Identities = 97/332 (29%), Positives = 171/332 (51%), Gaps = 22/332 (6%)

Query: 38  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
           C +C D+++G HYG S+C+GCKGFFRRS++KN +Y+C   + C+++K  RN+C+YCRL+K
Sbjct: 88  CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 147

Query: 98  CFRAGMKKEAVQNERDR----ISTRRSSYEDSSLPSINALLQAEVLSRQITSPV-----S 148
           CF  GM KE+V+N+R++    +     S   +  P +  L++    + Q T P       
Sbjct: 148 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 207

Query: 149 GINGDIRAKKIASIADVCESMKEQ----LLVLVEWAKYIPAFCELPLDDQVALLRAHAGE 204
               +   ++++   D+ +   E     ++  VE+AK +P F  L + DQ+ LL+A   +
Sbjct: 208 YTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 267

Query: 205 HLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQE----LQID 260
            L+L    R    +D +   +   + R      +M       L +LV  F      L++D
Sbjct: 268 ILILRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFANQLLPLEMD 322

Query: 261 DNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLP 320
           D E   L AI     D + L  P ++  L+  +  +L+ Y+  R+      F ++L+ + 
Sbjct: 323 DAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT 382

Query: 321 TLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
            L+SI+ +  E++  +K+     +  L+QEML
Sbjct: 383 DLRSISAKGAERVITLKMEIPGSMPPLIQEML 414


>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
          Length = 443

 Score =  159 bits (402), Expect = 4e-39
 Identities = 102/334 (30%), Positives = 168/334 (50%), Gaps = 26/334 (7%)

Query: 38  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
           C +C D+++G HYG SSC+GCKGFFRRS++KN +Y+C   + C+++K  RN+C+YCRL+K
Sbjct: 79  CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 138

Query: 98  CFRAGMKKEAVQNERDRISTR------RSSYEDSSLPSINALLQAEVLSRQITSP----- 146
           CF  GM KEAV+N+R++            SYE S  P +  L+     + Q T P     
Sbjct: 139 CFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELS--PQLEELITKVSKAHQETFPSLCQL 196

Query: 147 ---VSGINGDIRAKKIASIADVCESMKEQLLV-LVEWAKYIPAFCELPLDDQVALLRAHA 202
               +  + D R +    + D    +  + ++ +VE+AK +P F  L + DQ+ LL+A  
Sbjct: 197 GKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAAC 256

Query: 203 GEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQ----ELQ 258
            + L+L    R    +D +   +   + R      +M       L +LV  F      L+
Sbjct: 257 LDILMLRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFAGQLLPLE 311

Query: 259 IDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLL 318
           +DD E   L AI     D   L +P K+ +L+  +  +L  Y   R+      F  +L+ 
Sbjct: 312 MDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMK 371

Query: 319 LPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
           +  L+ I+ +  E+   +K+     +  L++EML
Sbjct: 372 ITDLRGISTKGAERAITLKMEIPGPMPPLIREML 405


>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
          Length = 454

 Score =  159 bits (402), Expect = 4e-39
 Identities = 102/334 (30%), Positives = 168/334 (50%), Gaps = 26/334 (7%)

Query: 38  CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
           C +C D+++G HYG SSC+GCKGFFRRS++KN +Y+C   + C+++K  RN+C+YCRL+K
Sbjct: 90  CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 149

Query: 98  CFRAGMKKEAVQNERDRISTR------RSSYEDSSLPSINALLQAEVLSRQITSP----- 146
           CF  GM KEAV+N+R++            SYE S  P +  L+     + Q T P     
Sbjct: 150 CFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELS--PQLEELITKVSKAHQETFPSLCQL 207

Query: 147 ---VSGINGDIRAKKIASIADVCESMKEQLLV-LVEWAKYIPAFCELPLDDQVALLRAHA 202
               +  + D R +    + D    +  + ++ +VE+AK +P F  L + DQ+ LL+A  
Sbjct: 208 GKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAAC 267

Query: 203 GEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQ----ELQ 258
            + L+L    R    +D +   +   + R      +M       L +LV  F      L+
Sbjct: 268 LDILMLRICTRYTPEQDTMTFSDGLTLNR-----TQMHNAGFGPLTDLVFAFAGQLLPLE 322

Query: 259 IDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLL 318
           +DD E   L AI     D   L +P K+ +L+  +  +L  Y   R+      F  +L+ 
Sbjct: 323 MDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMK 382

Query: 319 LPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
           +  L+ I+ +  E+   +K+     +  L++EML
Sbjct: 383 ITDLRGISTKGAERAITLKMEIPGPMPPLIREML 416


>gi|7706515 photoreceptor-specific nuclear receptor isoform a [Homo
           sapiens]
          Length = 367

 Score =  155 bits (393), Expect = 5e-38
 Identities = 110/345 (31%), Positives = 159/345 (46%), Gaps = 47/345 (13%)

Query: 3   SVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFF 62
           +V A   A   +S   SP        P  +  S  C +CGD ++GKHYG  +C+GC GFF
Sbjct: 12  TVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFF 71

Query: 63  RRSVRKNHMYSCRF-SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRR-- 119
           +RSVR+  +Y C+  +  C VDK  RNQC+ CRLKKC +AGM ++AVQNER   ST +  
Sbjct: 72  KRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVH 131

Query: 120 ----SSYEDSSLPSINALLQAEVLSRQITSPVSG------------INGDIRAKKIASIA 163
                S  +S   S+ A       S +  +P+S             I  +  AK     A
Sbjct: 132 LDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDA 191

Query: 164 D---------------------------VCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
           D                           + E+    L + V+WAK +P F  LP  DQV 
Sbjct: 192 DENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVI 251

Query: 197 LLRAHAGEHLLLGATKRSMVFKDV-LLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQ 255
           LL     E  LLGA + S+      LL   +            ++ +  R+L E +  F+
Sbjct: 252 LLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFR 311

Query: 256 ELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDY 300
            L +D  E+A +KA++ F P+ +GL DP  ++ L+ Q QV L  +
Sbjct: 312 ALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQH 356


>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  144 bits (364), Expect = 1e-34
 Identities = 99/335 (29%), Positives = 158/335 (47%), Gaps = 39/335 (11%)

Query: 29  PNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKN--HMYSCRFSRQCVVDKDK 86
           P+ L    LC +CGD+ATG HY   +C+GCKGFFRR+++KN    YSC++  +CV+DK  
Sbjct: 98  PSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVT 157

Query: 87  RNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA---------- 136
           RNQC+ CR KKC   GM  + V ++  R++ R+   E+        L ++          
Sbjct: 158 RNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDE 217

Query: 137 ------EVLSRQITSPVSGINGDIRAKKI------ASIADVCESMKEQLLV--------- 175
                  V    + +   G +   + K +      A I +  E  K  L           
Sbjct: 218 EWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIIT 277

Query: 176 -----LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVP 230
                +V++AK +P FCELP +DQ+ LL+    E + L A  R     + L L  +  V 
Sbjct: 278 PAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVT 337

Query: 231 RHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLR 290
           R   +   +  VS  I D L +      +DD E A L+A++    D  GL+   +I++ +
Sbjct: 338 RGQLKNGGLGVVSDAIFD-LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQ 396

Query: 291 SQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 325
               ++ E YIN R++     + +LL+ +  L+ I
Sbjct: 397 DSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMI 431


>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  144 bits (364), Expect = 1e-34
 Identities = 99/335 (29%), Positives = 158/335 (47%), Gaps = 39/335 (11%)

Query: 29  PNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKN--HMYSCRFSRQCVVDKDK 86
           P+ L    LC +CGD+ATG HY   +C+GCKGFFRR+++KN    YSC++  +CV+DK  
Sbjct: 98  PSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVT 157

Query: 87  RNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQA---------- 136
           RNQC+ CR KKC   GM  + V ++  R++ R+   E+        L ++          
Sbjct: 158 RNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDE 217

Query: 137 ------EVLSRQITSPVSGINGDIRAKKI------ASIADVCESMKEQLLV--------- 175
                  V    + +   G +   + K +      A I +  E  K  L           
Sbjct: 218 EWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIIT 277

Query: 176 -----LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVP 230
                +V++AK +P FCELP +DQ+ LL+    E + L A  R     + L L  +  V 
Sbjct: 278 PAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVT 337

Query: 231 RHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLR 290
           R   +   +  VS  I D L +      +DD E A L+A++    D  GL+   +I++ +
Sbjct: 338 RGQLKNGGLGVVSDAIFD-LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQ 396

Query: 291 SQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 325
               ++ E YIN R++     + +LL+ +  L+ I
Sbjct: 397 DSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMI 431


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,111,051
Number of Sequences: 37866
Number of extensions: 662866
Number of successful extensions: 2043
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 118
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 1710
Number of HSP's gapped (non-prelim): 209
length of query: 395
length of database: 18,247,518
effective HSP length: 104
effective length of query: 291
effective length of database: 14,309,454
effective search space: 4164051114
effective search space used: 4164051114
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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