Search of human proteins with 70995267

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
         (301 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|70995267 ankyrin repeat domain 29 [Homo sapiens]                   589   e-169
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   153   2e-37
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   150   1e-36
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          140   1e-33
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        140   2e-33
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       136   3e-32
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        136   3e-32
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        136   3e-32
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        136   3e-32
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        136   3e-32
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        134   1e-31
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        134   1e-31
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       133   2e-31
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   127   1e-29
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   127   1e-29
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   127   1e-29
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    127   1e-29
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   124   8e-29
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   124   8e-29
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho...   123   2e-28
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   120   1e-27
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                    120   1e-27
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   117   2e-26
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...   115   5e-26
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...   115   5e-26
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...   114   1e-25
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof...   113   2e-25
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  113   2e-25
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    110   2e-24
gi|148596917 fibronectin type III and ankyrin repeat domains 1 [...   109   3e-24

>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
          Length = 301

 Score =  589 bits (1519), Expect = e-169
 Identities = 301/301 (100%), Positives = 301/301 (100%)

Query: 1   MCRMSFKKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHID 60
           MCRMSFKKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHID
Sbjct: 1   MCRMSFKKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHID 60

Query: 61  CVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAAS 120
           CVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAAS
Sbjct: 61  CVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAAS 120

Query: 121 QYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTA 180
           QYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTA
Sbjct: 121 QYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTA 180

Query: 181 PLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL 240
           PLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL
Sbjct: 181 PLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL 240

Query: 241 KNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLRSKEGPRK 300
           KNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLRSKEGPRK
Sbjct: 241 KNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLRSKEGPRK 300

Query: 301 S 301
           S
Sbjct: 301 S 301


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  153 bits (386), Expect = 2e-37
 Identities = 98/274 (35%), Positives = 145/274 (52%), Gaps = 7/274 (2%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AAR+G+  ++  L+  G  +++  D  G T L  AA+ GH + V  L+  G  ++     
Sbjct: 585 AARQGHTKVVNCLIGCG-ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD 643

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
             TAL  AA  GH D+V  L   GA       +G TAL+AA+  GH ++VE LL HGA +
Sbjct: 644 SRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEV 703

Query: 139 HDQLYDGATALFLAA-----QGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
           + +  DG TAL +AA       G+  V+ LL+  GA+V+   +DG  PL +A+  GH +V
Sbjct: 704 NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763

Query: 194 VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAAVL 252
           V ++L  GAD D   N+G T LL AA+ G+  V+  LL +   +  I   G + L  A  
Sbjct: 764 VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASA 823

Query: 253 SGNIKTVALLLEAGADPSLRNKANELPAELTKNE 286
            GN++ V  LL+ G D + R+ A   P  +   E
Sbjct: 824 QGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFE 857



 Score =  145 bits (367), Expect = 3e-35
 Identities = 98/247 (39%), Positives = 136/247 (55%), Gaps = 7/247 (2%)

Query: 28  LKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAA 87
           ++ LL++G     C DS+G TLL  AAY+G +D V  LV +GAD+ ++   G T L  AA
Sbjct: 528 IRTLLDNGASVNQC-DSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAA 586

Query: 88  QQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGAT 147
           +QGH  VV  L G GA+     +DG TAL +A+  GH +VV  LL  G  +     D  T
Sbjct: 587 RQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRT 646

Query: 148 ALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAA 207
           AL  AA GG+ D++  LL  GA+VN+   +G   L  A+ MGH E+V  +L  GA+ +  
Sbjct: 647 ALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHE 706

Query: 208 RNDGTTALLKA-----ANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIKTVAL 261
             DG TAL  A     A+KG+  V+  L+     +    K+G + L  A   G++  V L
Sbjct: 707 DVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDL 766

Query: 262 LLEAGAD 268
           LLE GAD
Sbjct: 767 LLEGGAD 773



 Score =  142 bits (359), Expect = 3e-34
 Identities = 102/289 (35%), Positives = 143/289 (49%), Gaps = 25/289 (8%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G+  ++  LL +G V VDC D+   T L  AA+ GH D V  L+  GA++N     
Sbjct: 618 AAWGGHTEVVSALLYAG-VKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNE 676

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAAS-----QYGHMQVVETLLK 133
           G TAL  AA  GH ++V  L   GA       DG TAL  A+       GH  VV  L+ 
Sbjct: 677 GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLID 736

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            GA +     DG T L +AA  G++DV+ LLL  GA V+    +G  PL  A+ MGH+ V
Sbjct: 737 RGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASV 796

Query: 194 VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKN-----GTSALH 248
           V  +L  GA  D+  ++G T L  A+ +G  +V++ LL      G+ +N     G + LH
Sbjct: 797 VNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLD----RGLDENHRDDAGWTPLH 852

Query: 249 AAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLRSKEG 297
            A   G+      L+E GA  +          E+  + RI  +L S+EG
Sbjct: 853 MAAFEGHRLICEALIEQGARTN----------EIDNDGRIPFILASQEG 891



 Score =  130 bits (328), Expect = 1e-30
 Identities = 86/250 (34%), Positives = 135/250 (54%), Gaps = 2/250 (0%)

Query: 19   AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
            AA  G+ +++  LL  G   VD  DS G T+L +A+  G+++ VR L+ +G D N + ++
Sbjct: 788  AASMGHASVVNTLLFWGAA-VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDA 846

Query: 79   GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
            G T L  AA +GH  +   L   GA T     DG    + ASQ GH   V+ LL++ +NI
Sbjct: 847  GWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNI 906

Query: 139  HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
              + YDG  AL +AA  G+ D++ LL + GA VN    DG   L+I +      +    L
Sbjct: 907  DQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFL 966

Query: 199  LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKN-GTSALHAAVLSGNIK 257
              GA+ +A+  +G TAL  +  +G+ ++++ L+ +   +    N   SAL +A   G++K
Sbjct: 967  ENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVK 1026

Query: 258  TVALLLEAGA 267
             V LL+E GA
Sbjct: 1027 VVQLLIEHGA 1036



 Score =  129 bits (325), Expect = 2e-30
 Identities = 84/250 (33%), Positives = 131/250 (52%), Gaps = 2/250 (0%)

Query: 20  ARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESG 79
           A +G+ +++ LL++ G  +VD  D  G T L+VAAY GH+D V  L+  GAD++    +G
Sbjct: 723 ASKGHASVVSLLIDRG-AEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNG 781

Query: 80  TTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIH 139
            T L  AA  GH  VV  L  +GA+ +    +G T L  AS  G+++VV TLL  G + +
Sbjct: 782 RTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN 841

Query: 140 DQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLL 199
            +   G T L +AA  G+  +   L+  GA+ N+   DG  P  +ASQ GH + V+++L 
Sbjct: 842 HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE 901

Query: 200 RGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIKT 258
             ++ D    DG  AL  AA +G+ D+++ L      +     +G   L+   L   +  
Sbjct: 902 NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTM 961

Query: 259 VALLLEAGAD 268
               LE GA+
Sbjct: 962 AEYFLENGAN 971



 Score =  122 bits (306), Expect = 4e-28
 Identities = 86/260 (33%), Positives = 130/260 (50%), Gaps = 5/260 (1%)

Query: 19  AARRGNLALLKLLLNSG----RVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           AA  G+  +++ LL+ G      DVD R +     L V A  GH   V  L+ +GA+++ 
Sbjct: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743

Query: 75  QRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKH 134
             + G T L  AA +GH DVV  L   GA  +    +G T LLAA+  GH  VV TLL  
Sbjct: 744 CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW 803

Query: 135 GANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVV 194
           GA +     +G T L +A+  G ++V+R LL  G   N     G  PL +A+  GH  + 
Sbjct: 804 GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLIC 863

Query: 195 RVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLS 253
             ++ +GA  +   NDG    + A+ +G+ D ++ LL+    +     +G +AL  A L 
Sbjct: 864 EALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALE 923

Query: 254 GNIKTVALLLEAGADPSLRN 273
           G+   V LL   GAD + ++
Sbjct: 924 GHRDIVELLFSHGADVNCKD 943



 Score =  120 bits (302), Expect = 1e-27
 Identities = 90/252 (35%), Positives = 128/252 (50%), Gaps = 7/252 (2%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G+  ++  LL  G  +V+  D+ G T L+ AAY GH + V  L+  GA++N +   
Sbjct: 651 AAWGGHEDIVLNLLQHG-AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVD 709

Query: 79  GTTALFFA-----AQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
           G TAL  A     A +GH  VV  L   GA  +   KDG T LL A+  GH+ VV+ LL+
Sbjct: 710 GRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            GA++     +G T L  AA  G+  V+  LL  GA V+    +G   L IAS  G+ EV
Sbjct: 770 GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829

Query: 194 VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKN-GTSALHAAVL 252
           VR +L RG D +   + G T L  AA +G+  + + L++       + N G      A  
Sbjct: 830 VRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQ 889

Query: 253 SGNIKTVALLLE 264
            G+   V +LLE
Sbjct: 890 EGHYDCVQILLE 901



 Score =  119 bits (297), Expect = 4e-27
 Identities = 88/287 (30%), Positives = 145/287 (50%), Gaps = 9/287 (3%)

Query: 10   TPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQG 69
            TPL  AAF   R    AL++    +  +D D     G    ++A+  GH DCV+ L+   
Sbjct: 849  TPLHMAAFEGHRLICEALIEQGARTNEIDND-----GRIPFILASQEGHYDCVQILLENK 903

Query: 70   ADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVE 129
            ++I+ +   G  AL  AA +GH D+V  LF  GA    +  DG   L   +    + + E
Sbjct: 904  SNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAE 963

Query: 130  TLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMG 189
              L++GAN+     +G TAL ++   G+++++++L+A  A VN    +  + L  A+  G
Sbjct: 964  YFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQG 1023

Query: 190  HSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKN-GTSALH 248
            H +VV++++  GA  D   N G TAL  AA +G+ DV++ LL+           G +A+ 
Sbjct: 1024 HVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMR 1083

Query: 249  AAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLRSK 295
             A  +G+ + + LL + GA  S  N  +  P   T  ++ L+ L SK
Sbjct: 1084 VAAKNGHSQIIKLLEKYGA--SSLNGCSPSPVH-TMEQKPLQSLSSK 1127



 Score =  119 bits (297), Expect = 4e-27
 Identities = 86/270 (31%), Positives = 137/270 (50%), Gaps = 13/270 (4%)

Query: 19   AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
            A++ G+   +++LL + + ++D R   G   L VAA  GH D V  L   GAD+N +   
Sbjct: 887  ASQEGHYDCVQILLEN-KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDAD 945

Query: 79   GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
            G   L+  A +    +  +    GA+ E    +G TAL  +   GHM++V+ L+ + A++
Sbjct: 946  GRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADV 1005

Query: 139  HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
            +    +  +AL  AA  G++ V++LL+  GA V+     G   L IA+Q GH +VV+V+L
Sbjct: 1006 NAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLL 1065

Query: 199  LRGADRDAARNDGTTALLKAANKGYNDVIKELLKF----------SPTLGILKNGTSALH 248
              GAD + A   G TA+  AA  G++ +IK L K+          SP   + +    +L 
Sbjct: 1066 EHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLS 1125

Query: 249  AAVLSGNIKTVALLLEAGAD--PSLRNKAN 276
            + V S  IK+ +     G D  PSLR   N
Sbjct: 1126 SKVQSLTIKSNSSGSTGGGDMQPSLRGLPN 1155



 Score =  117 bits (293), Expect = 1e-26
 Identities = 86/248 (34%), Positives = 127/248 (51%), Gaps = 9/248 (3%)

Query: 27  LLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFA 86
           +L+LL+ +G   V+  D    T  +V       D +R L+  GA +N    +G T L  A
Sbjct: 496 VLQLLVKAG-AHVNSEDDR--TSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA 552

Query: 87  AQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGA 146
           A  G  DVV  L   GA  E     G T L  A++ GH +VV  L+  GANI+    DG 
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612

Query: 147 TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDA 206
           TAL  AA GG+ +V+  LL +G KV+    D    L  A+  GH ++V  +L  GA+ + 
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672

Query: 207 ARNDGTTALLKAANKGYNDVIKELLKFSPTLGILK-NGTSALHAAVL-----SGNIKTVA 260
           A N+G TAL+ AA  G+ ++++ LL     +     +G +AL  A L      G+   V+
Sbjct: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732

Query: 261 LLLEAGAD 268
           LL++ GA+
Sbjct: 733 LLIDRGAE 740



 Score = 30.4 bits (67), Expect = 2.0
 Identities = 25/96 (26%), Positives = 48/96 (50%), Gaps = 3/96 (3%)

Query: 192 EVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAA 250
           EV+++++  GA  ++  +D T+ +++ A +   D I+ LL    ++     NG + L  A
Sbjct: 495 EVLQLLVKAGAHVNS-EDDRTSCIVRQALER-EDSIRTLLDNGASVNQCDSNGRTLLANA 552

Query: 251 VLSGNIKTVALLLEAGADPSLRNKANELPAELTKNE 286
             SG++  V LL+  GAD  + +     P  L   +
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQ 588


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  150 bits (379), Expect = 1e-36
 Identities = 97/255 (38%), Positives = 142/255 (55%), Gaps = 2/255 (0%)

Query: 24  NLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTAL 83
           N+  LK LL   + DVD R+  G T LM+AA  G+++ V+EL+  GA+ NL+     TAL
Sbjct: 17  NIPALKALLEKCK-DVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75

Query: 84  FFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLY 143
             A+++GH  +V  L   G + E R   G TAL+ A   G   VVE LL HGAN      
Sbjct: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135

Query: 144 DGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGAD 203
                +  AA  G+ D++ LLL +GAKVN   + GT PL  A++ GH E V+ +L  GAD
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195

Query: 204 RDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIKTVALL 262
            D    +  TAL+ A   GY   +KE+LK +P + +  K+G +AL  A   G+ + V  L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255

Query: 263 LEAGADPSLRNKANE 277
           L+AG   ++ +++ +
Sbjct: 256 LDAGTYVNIPDRSGD 270



 Score =  144 bits (363), Expect = 9e-35
 Identities = 91/266 (34%), Positives = 142/266 (53%), Gaps = 5/266 (1%)

Query: 18  WAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
           WAA RG+  ++ LLL +G   V+C D +GTT L+ AA  GH++CV+ L+  GAD++ +  
Sbjct: 143 WAAGRGHADIVHLLLQNG-AKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
           +  TAL  A + G+   V+ +     +     KDG TAL+ AS+ GH ++V+ LL  G  
Sbjct: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVM 197
           ++     G T L  A +GG+++++R LL   A ++   QD    L+ A + G++ +VR +
Sbjct: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321

Query: 198 LLRGADRDAARNDGTTALLKAANKGYNDVIKELL-KFSPTLGILKNGTSALHAAVLSGNI 256
           L    D +    DG T L+KA      +V++ LL K +    + K G + LH A+   + 
Sbjct: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381

Query: 257 KTVALLLEAGADPSL---RNKANELP 279
           K   LLL    D  L    NKA E P
Sbjct: 382 KLAELLLRNPKDGRLLYRPNKAGETP 407



 Score =  139 bits (351), Expect = 2e-33
 Identities = 92/278 (33%), Positives = 147/278 (52%), Gaps = 2/278 (0%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A  WA  +G   +++LLL+ G  +      +    ++ AA  GH D V  L+  GA +N 
Sbjct: 107 ALMWACYKGRTDVVELLLSHG-ANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC 165

Query: 75  QRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKH 134
             + GTT L +AA++GH + V+ L   GA  +    +  TAL+ A + G+ Q V+ +LK 
Sbjct: 166 SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKR 225

Query: 135 GANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVV 194
             N++    DG TAL +A++ G+ ++++ LL +G  VN P + G   L  A + GH E+V
Sbjct: 226 NPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIV 285

Query: 195 RVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLS 253
           R +L + AD D    D  TAL  A  KG   +++++L+ +P   I  K+G + L  A   
Sbjct: 286 RALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKM 345

Query: 254 GNIKTVALLLEAGADPSLRNKANELPAELTKNERILRL 291
            NI+ V LLL+ GA  S  +K  + P  +    R  +L
Sbjct: 346 RNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383



 Score =  129 bits (325), Expect = 2e-30
 Identities = 88/281 (31%), Positives = 146/281 (51%), Gaps = 5/281 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A++ G++ +++ LL  G V+++ RD  G T LM A Y G  D V  L+  GA+ ++    
Sbjct: 78  ASKEGHVHIVEELLKCG-VNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
               + +AA +GH D+V  L   GA      K G T L+ A++ GH++ V+ LL  GA++
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
             +  +  TAL +A +GGY   ++ +L     VN   +DG   L IAS+ GH+E+V+ +L
Sbjct: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIK 257
             G   +     G T L+ A   G+ ++++ LL+    + I  ++  +AL+ AV  GN  
Sbjct: 257 DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT 316

Query: 258 TVALLLEAGADPSLRNKANELP---AELTKNERILRLLRSK 295
            V  +L+   D  +  K  E P   A   +N  ++ LL  K
Sbjct: 317 MVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDK 357


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  140 bits (354), Expect = 1e-33
 Identities = 93/289 (32%), Positives = 148/289 (51%), Gaps = 2/289 (0%)

Query: 7   KKETPLANAAFWAARRGNLALLKLLLNS-GRVDVDCRDSHGTTLLMVAAYAGHIDCVREL 65
           ++++ +  A   A    N+  L+ LL S    DV+  + HGT  L++AA  G+I  ++ L
Sbjct: 339 EEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLL 398

Query: 66  VLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHM 125
           + +G+ I++Q + G+ A+++AA+ GH D ++FL       + + K G  AL  A++YGH 
Sbjct: 399 IKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHA 458

Query: 126 QVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIA 185
            V + L   G+N + Q  +  T L  AA  GY  V + L  +G  VN   ++G  PL  A
Sbjct: 459 DVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTA 518

Query: 186 SQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGT 244
           S  G+ ++V  +   GAD +A   DG  AL  A  +   +VIK LL     +    ++G 
Sbjct: 519 SARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGN 578

Query: 245 SALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLR 293
           + LH A   GN+  V  L EA  +  + NK    P  L  N  IL ++R
Sbjct: 579 TPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR 627



 Score =  119 bits (297), Expect = 4e-27
 Identities = 74/218 (33%), Positives = 115/218 (52%), Gaps = 1/218 (0%)

Query: 13  ANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADI 72
           +NA +WAAR G++  LK L +  +  +D +D  G   L VAA  GH D  + L   G++ 
Sbjct: 413 SNAVYWAARHGHVDTLKFL-SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNP 471

Query: 73  NLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLL 132
           N+Q +   T L  AA  G+  V + L   G +   + ++G T LL AS  G+  +VE L 
Sbjct: 472 NIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLA 531

Query: 133 KHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSE 192
           +HGA+++    DG  AL LA +   ++VI+ LL+ G  V+   + G  PL +A + G+  
Sbjct: 532 EHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMP 591

Query: 193 VVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKEL 230
           +V  +     + D +   G T L  AAN G  DV++ L
Sbjct: 592 IVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYL 629



 Score = 82.4 bits (202), Expect = 4e-16
 Identities = 59/191 (30%), Positives = 92/191 (48%), Gaps = 5/191 (2%)

Query: 7   KKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV 66
           ++ETPL  AA+     G  ++ K L  +G  +V+ ++  G T L+ A+  G+ D V  L 
Sbjct: 477 EEETPLHCAAW----HGYYSVAKALCEAG-CNVNIKNREGETPLLTASARGYHDIVECLA 531

Query: 67  LQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQ 126
             GAD+N   + G  AL  A ++   +V++ L   G   +++ + G T L  A + G+M 
Sbjct: 532 EHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMP 591

Query: 127 VVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIAS 186
           +V  L +   N+      G T L LAA  G LDV+R L   GA V     DG     +A 
Sbjct: 592 IVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLAR 651

Query: 187 QMGHSEVVRVM 197
              H  V  ++
Sbjct: 652 SEQHEHVAGLL 662



 Score = 62.4 bits (150), Expect = 5e-10
 Identities = 45/125 (36%), Positives = 61/125 (48%), Gaps = 1/125 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A RR  + ++K LL+ G   VD +D HG T L VA   G++  V  L     ++++  + 
Sbjct: 551 AVRRCQMEVIKTLLSQGCF-VDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKY 609

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AA  G  DVVR+L   GAS E  T DG TA   A    H  V   L +   + 
Sbjct: 610 GRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDT 669

Query: 139 HDQLY 143
           H  L+
Sbjct: 670 HRGLF 674


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  140 bits (352), Expect = 2e-33
 Identities = 96/281 (34%), Positives = 141/281 (50%), Gaps = 31/281 (11%)

Query: 14  NAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADIN 73
           NA   A++ G++ ++  LL     +VD     G T L +A+ AG  + V+ LV  GA++N
Sbjct: 76  NALHLASKEGHVEVVSELLQR-EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVN 134

Query: 74  LQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
            Q ++G T L+ AAQ+ H +VV+FL   GAS    T+DG T L  A Q GH QVV  LL+
Sbjct: 135 AQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE 194

Query: 134 HGA-----------------------------NIHDQLYDGATALFLAAQGGYLDVIRLL 164
           +                               N   +   G T L +AA  G ++V  LL
Sbjct: 195 NDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLL 254

Query: 165 LASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYN 224
           L   A V+   ++   PL +AS+ G++ +V+++L RGA  DA   DG T L   A  G+ 
Sbjct: 255 LNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHE 314

Query: 225 DVIKELL-KFSPTLGILKNGTSALHAAVLSGNIKTVALLLE 264
            V++ LL + +P L   KNG S LH A    ++  V LLL+
Sbjct: 315 QVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ 355



 Score =  130 bits (327), Expect = 1e-30
 Identities = 89/278 (32%), Positives = 144/278 (51%), Gaps = 5/278 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A +  +L  ++LLL    V VD   +   T L VAA+ GH    + L+ + A+ N +  +
Sbjct: 341 ATQGDHLNCVQLLLQHN-VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALN 399

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A ++    V+  L   GAS +  T+ G T +  A+  GH+ +V  L+ HGA+ 
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +     G TAL +AA+ G  +V+R L+  GA+V    +D   PL I++++G +++V+ +L
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
            +GA  +AA   G T L  +A +G+ DV   LL    +L I  K G + LH A   G ++
Sbjct: 520 QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLE 579

Query: 258 TVALLLEAGADPSLRNKANELPAELT---KNERILRLL 292
              LLL+  A P    K+   P  +     N+++  LL
Sbjct: 580 VANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617



 Score =  125 bits (313), Expect = 6e-29
 Identities = 90/302 (29%), Positives = 140/302 (46%), Gaps = 35/302 (11%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A ++  + +++LLL  G   +      G T + VAA+ GH++ V +L+  GA  N     
Sbjct: 407 ACKKNRIKVMELLLKHG-ASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR 465

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKD--------------------------- 111
           G TAL  AA+ G  +VVR+L   GA  E + KD                           
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 525

Query: 112 ------GGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLL 165
                 G T L  +++ GH  V   LL HGA++      G T L +AA+ G L+V  LLL
Sbjct: 526 NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585

Query: 166 ASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYND 225
              A  +   + G  PL +A+   + +V  ++L +GA   AA  +G T L  AA K   D
Sbjct: 586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMD 645

Query: 226 VIKELLKF-SPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTK 284
           +   LL++ +    + + G +++H A   G++  V+LLL   A+ +L NK+   P  L  
Sbjct: 646 IATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAA 705

Query: 285 NE 286
            E
Sbjct: 706 QE 707



 Score =  123 bits (308), Expect = 2e-28
 Identities = 86/244 (35%), Positives = 128/244 (52%), Gaps = 8/244 (3%)

Query: 53  AAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDG 112
           AA AGH++   + +  G DIN+  ++G  AL  A+++GH +VV  L    A+ +  TK G
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 113 GTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVN 172
            TAL  AS  G  +VV+ L+ +GAN++ Q  +G T L++AAQ  +L+V++ LL +GA  +
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167

Query: 173 QPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLK 232
              +DG  PL +A Q GH +VV ++L    + D        AL  AA K        LL+
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLLL----ENDTKGKVRLPALHIAARKDDTKAAALLLQ 223

Query: 233 FSPTLGI-LKNGTSALHAAVLSGNIKTVALLLE--AGADPSLRNKANEL-PAELTKNERI 288
                 +  K+G + LH A   GNI    LLL   A  D + RN    L  A    N  +
Sbjct: 224 NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANM 283

Query: 289 LRLL 292
           ++LL
Sbjct: 284 VKLL 287



 Score =  123 bits (308), Expect = 2e-28
 Identities = 83/266 (31%), Positives = 128/266 (48%), Gaps = 2/266 (0%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A   AAR G   +++ L+  G   V+ +     T L ++A  G  D V++L+ QGA  N 
Sbjct: 469 ALHMAARSGQAEVVRYLVQDG-AQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527

Query: 75  QRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKH 134
              SG T L  +A++GH DV  FL   GAS    TK G T L  A++YG ++V   LL+ 
Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587

Query: 135 GANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVV 194
            A+       G T L +AA      V  LLL  GA  +   ++G  PL IA++    ++ 
Sbjct: 588 SASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIA 647

Query: 195 RVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLS 253
             +L  GAD +A    G  ++  AA +G+ D++  LL  +  + +  K+G + LH A   
Sbjct: 648 TTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQE 707

Query: 254 GNIKTVALLLEAGADPSLRNKANELP 279
             +    +L+  GA    + K    P
Sbjct: 708 DRVNVAEVLVNQGAHVDAQTKMGYTP 733



 Score =  121 bits (303), Expect = 9e-28
 Identities = 81/261 (31%), Positives = 138/261 (52%), Gaps = 4/261 (1%)

Query: 19  AARRGNLALLKLLL-NSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
           AAR+ +     LLL N    DV+ +   G T L +AA+ G+I+    L+ + A ++    
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKS--GFTPLHIAAHYGNINVATLLLNRAAAVDFTAR 266

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
           +  T L  A+++G+ ++V+ L   GA  + +T+DG T L   ++ GH QVVE LL   A 
Sbjct: 267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVM 197
           I  +  +G + L +A QG +L+ ++LLL     V+    D    L +A+  GH +V +V+
Sbjct: 327 ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386

Query: 198 LLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAAVLSGNI 256
           L + A+ +A   +G T L  A  K    V++ LLK   ++  + ++G + +H A   G++
Sbjct: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHV 446

Query: 257 KTVALLLEAGADPSLRNKANE 277
             V+ L+  GA P+  N   E
Sbjct: 447 NIVSQLMHHGASPNTTNVRGE 467



 Score =  117 bits (294), Expect = 1e-26
 Identities = 81/269 (30%), Positives = 130/269 (48%), Gaps = 2/269 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A++RGN  ++KLLL+ G   +D +   G T L   A +GH   V  L+ + A I  + ++
Sbjct: 275 ASKRGNANMVKLLLDRG-AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKN 333

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G + L  A Q  H + V+ L       +  T D  TAL  A+  GH +V + LL   AN 
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP 393

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +  +G T L +A +   + V+ LLL  GA +    + G  P+ +A+ MGH  +V  ++
Sbjct: 394 NAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM 453

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAAVLSGNIK 257
             GA  +     G TAL  AA  G  +V++ L++    +    K+  + LH +   G   
Sbjct: 454 HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 513

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNE 286
            V  LL+ GA P+    +   P  L+  E
Sbjct: 514 IVQQLLQQGASPNAATTSGYTPLHLSARE 542



 Score =  110 bits (274), Expect = 2e-24
 Identities = 79/253 (31%), Positives = 122/253 (48%), Gaps = 2/253 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           +AR G+  +   LL+ G   +      G T L VAA  G ++    L+ + A  +   +S
Sbjct: 539 SAREGHEDVAAFLLDHG-ASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKS 597

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AA   +  V   L   GAS     K+G T L  A++   M +  TLL++GA+ 
Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA 657

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +     G  ++ LAAQ G++D++ LLL   A VN   + G  PL +A+Q     V  V++
Sbjct: 658 NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
            +GA  DA    G T L    + G   ++  LL+ S  +    KNG + LH A   G+  
Sbjct: 718 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTH 777

Query: 258 TVALLLEAGADPS 270
            + +LL+  A P+
Sbjct: 778 IINVLLQNNASPN 790



 Score =  106 bits (265), Expect = 2e-23
 Identities = 70/212 (33%), Positives = 100/212 (47%), Gaps = 1/212 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA   N  +  LLL+ G         +G T L +AA    +D    L+  GAD N     
Sbjct: 605 AAHYDNQKVALLLLDQG-ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQ 663

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G  ++  AAQ+GH D+V  L G  A+     K G T L  A+Q   + V E L+  GA++
Sbjct: 664 GIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV 723

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
             Q   G T L +    G + ++  LL   AKVN   ++G  PL  A+Q GH+ ++ V+L
Sbjct: 724 DAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 783

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKEL 230
              A  +    +G TAL  A   GY  V+  L
Sbjct: 784 QNNASPNELTVNGNTALGIARRLGYISVVDTL 815



 Score =  101 bits (252), Expect = 7e-22
 Identities = 89/290 (30%), Positives = 133/290 (45%), Gaps = 39/290 (13%)

Query: 10  TPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQG 69
           TPL    + AA+  +L ++K LL++G          G T L VA   GH D V  L+L+ 
Sbjct: 142 TPL----YMAAQENHLEVVKFLLDNG-ASQSLATEDGFTPLAVALQQGH-DQVVSLLLEN 195

Query: 70  A------------------------------DINLQRESGTTALFFAAQQGHNDVVRFLF 99
                                          + +++ +SG T L  AA  G+ +V   L 
Sbjct: 196 DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLL 255

Query: 100 GFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLD 159
              A+ +F  ++  T L  AS+ G+  +V+ LL  GA I  +  DG T L   A+ G+  
Sbjct: 256 NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQ 315

Query: 160 VIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAA 219
           V+ +LL   A +    ++G +PL +A+Q  H   V+++L      D   ND  TAL  AA
Sbjct: 316 VVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAA 375

Query: 220 NKGYNDVIKELL--KFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGA 267
           + G+  V K LL  K +P    L NG + LH A     IK + LLL+ GA
Sbjct: 376 HCGHYKVAKVLLDKKANPNAKAL-NGFTPLHIACKKNRIKVMELLLKHGA 424


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  136 bits (342), Expect = 3e-32
 Identities = 87/265 (32%), Positives = 146/265 (55%), Gaps = 2/265 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AAR  +     +LL +   + D     G T L +AA+  +++  + L+ +GA +N   ++
Sbjct: 213 AARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 271

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A+++G+  +VR L   GA  E +TKD  T L  A++ GH+++ E LL HGA I
Sbjct: 272 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 331

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
             +  +G + + +AAQG +LD +RLLL   A+++    D   PL +A+  GH  V +V+L
Sbjct: 332 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 391

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAAVLSGNIK 257
            +GA  ++   +G T L  A  K +  V++ LLK   ++  + ++G + LH A   G++ 
Sbjct: 392 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 451

Query: 258 TVALLLEAGADPSLRNKANELPAEL 282
            V  LL+ GA P++ N   E P  +
Sbjct: 452 IVKNLLQRGASPNVSNVKVETPLHM 476



 Score =  135 bits (339), Expect = 6e-32
 Identities = 89/269 (33%), Positives = 138/269 (51%), Gaps = 2/269 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A+RRGN+ +++LLL+ G   ++ +     T L  AA  GH+     L+  GA I  + ++
Sbjct: 279 ASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G + +  AAQ  H D VR L  + A  +  T D  T L  A+  GH +V + LL  GA  
Sbjct: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 397

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +  +G T L +A +  ++ V+ LLL +GA ++   + G  PL +AS MGH  +V+ +L
Sbjct: 398 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 457

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
            RGA  + +     T L  AA  G+ +V K LL+    +    K+  + LH A   G+  
Sbjct: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNE 286
            V LLLE  A+P+L   A   P  +   E
Sbjct: 518 MVKLLLENNANPNLATTAGHTPLHIAARE 546



 Score =  122 bits (307), Expect = 3e-28
 Identities = 92/283 (32%), Positives = 144/283 (50%), Gaps = 5/283 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+  +L  ++LLL       D    H  T L VAA+ GH    + L+ +GA  N +  +
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 403

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A ++ H  V+  L   GAS +  T+ G T L  AS  GH+ +V+ LL+ GA+ 
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +       T L +AA+ G+ +V + LL + AKVN   +D   PL  A+++GH+ +V+++L
Sbjct: 464 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 523

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELL-KFSPTLGILKNGTSALHAAVLSGNIK 257
              A+ + A   G T L  AA +G+ + +  LL K +    + K G + LH A   G ++
Sbjct: 524 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 583

Query: 258 TVALLLEAGADPSLRNKANELPAELT---KNERILRLLRSKEG 297
              LLLE  A P+   K    P  +     N  I++LL  + G
Sbjct: 584 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626



 Score =  119 bits (297), Expect = 4e-27
 Identities = 91/290 (31%), Positives = 143/290 (49%), Gaps = 10/290 (3%)

Query: 7   KKETPLANAAFWAARRGNLALLKLLL-NSGRVDVDCRDSHGTTLLMVAAYAGHIDCVREL 65
           K ETPL      AAR G+  + K LL N  +V+   +D    T L  AA  GH + V+ L
Sbjct: 469 KVETPL----HMAARAGHTEVAKYLLQNKAKVNAKAKDDQ--TPLHCAARIGHTNMVKLL 522

Query: 66  VLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHM 125
           +   A+ NL   +G T L  AA++GH + V  L    AS    TK G T L  A++YG +
Sbjct: 523 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 582

Query: 126 QVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIA 185
           +V E LL+  A+ +    +G T L +A     LD+++LLL  G   + P  +G  PL IA
Sbjct: 583 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 642

Query: 186 SQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELL--KFSPTLGILKNG 243
           ++    EV R +L  G   +A    G T L  AA +G+ +++  LL  + +  LG  K+G
Sbjct: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG-NKSG 701

Query: 244 TSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLR 293
            + LH     G++    +L++ G       +    P  +  +   ++L++
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 751



 Score =  114 bits (285), Expect = 1e-25
 Identities = 88/307 (28%), Positives = 146/307 (47%), Gaps = 34/307 (11%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G   +++ L+N G  +V+ +   G T L +AA   H++ V+ L+  GA+ N+  E 
Sbjct: 118 AALAGQDEVVRELVNYG-ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED 176

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFR-----------------------------T 109
           G T L  A QQGH +VV  L  +G   + R                             +
Sbjct: 177 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 236

Query: 110 KDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGA 169
           K G T L  A+ Y ++ V + LL  GA+++    +G T L +A++ G + ++RLLL  GA
Sbjct: 237 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 296

Query: 170 KVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKE 229
           ++    +D   PL  A++ GH  +  ++L  GA   A   +G + +  AA   + D ++ 
Sbjct: 297 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356

Query: 230 LLKFSPTL-GILKNGTSALHAAVLSGNIKTVALLLEAGADPSLR--NKANELPAELTKNE 286
           LL++   +  I  +  + LH A   G+ +   +LL+ GA P+ R  N    L     KN 
Sbjct: 357 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 416

Query: 287 -RILRLL 292
            R++ LL
Sbjct: 417 VRVMELL 423



 Score =  110 bits (276), Expect = 1e-24
 Identities = 82/267 (30%), Positives = 125/267 (46%), Gaps = 2/267 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AAR G++  +  LL        C    G T L VAA  G +     L+ + A  N   ++
Sbjct: 543 AAREGHVETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 601

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A    + D+V+ L   G S      +G T L  A++   ++V  +LL++G + 
Sbjct: 602 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 661

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +   G T L LAAQ G+ +++ LLL+  A  N   + G  PL + +Q GH  V  V++
Sbjct: 662 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 721

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
             G   DA    G T L  A++ G   ++K LL+    +    K G S LH A   G+  
Sbjct: 722 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTD 781

Query: 258 TVALLLEAGADPSLRNKANELPAELTK 284
            V LLL+ GA P+  +     P  + K
Sbjct: 782 IVTLLLKNGASPNEVSSDGTTPLAIAK 808



 Score =  110 bits (275), Expect = 2e-24
 Identities = 85/268 (31%), Positives = 126/268 (47%), Gaps = 30/268 (11%)

Query: 42  RDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGF 101
           + +   T  + AA +G++D   + +  G DIN   ++G   L  A+++GH  +V  L   
Sbjct: 41  KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100

Query: 102 GASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVI 161
               E  TK G TAL  A+  G  +VV  L+ +GAN++ Q   G T L++AAQ  +L+V+
Sbjct: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160

Query: 162 RLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRG--------ADRDAARNDGT- 212
           + LL +GA  N   +DG  PL +A Q GH  VV  ++  G        A   AARND T 
Sbjct: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 220

Query: 213 TALLKAANKGYNDVIKE--------------------LLKFSPTLGIL-KNGTSALHAAV 251
           TA +   N    DV+ +                    LL    ++    +NG + LH A 
Sbjct: 221 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 280

Query: 252 LSGNIKTVALLLEAGADPSLRNKANELP 279
             GN+  V LLL+ GA    + K    P
Sbjct: 281 RRGNVIMVRLLLDRGAQIETKTKDELTP 308



 Score =  110 bits (275), Expect = 2e-24
 Identities = 72/213 (33%), Positives = 106/213 (49%), Gaps = 4/213 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A    NL ++KLLL  G         +G T L +AA    ++  R L+  G   N +   
Sbjct: 609 AVHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 667

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AAQ+GH ++V  L    A+     K G T L   +Q GH+ V + L+KHG  +
Sbjct: 668 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 727

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
                 G T L +A+  G + +++ LL   A VN   + G +PL  A+Q GH+++V ++L
Sbjct: 728 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 787

Query: 199 LRGADRDAARNDGTTALLKAANKGY---NDVIK 228
             GA  +   +DGTT L  A   GY    DV+K
Sbjct: 788 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820



 Score =  110 bits (274), Expect = 2e-24
 Identities = 87/277 (31%), Positives = 130/277 (46%), Gaps = 2/277 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G+  + K+LL+ G    + R  +G T L +A    H+  +  L+  GA I+   ES
Sbjct: 378 AAHCGHHRVAKVLLDKG-AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES 436

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A+  GH  +V+ L   GAS         T L  A++ GH +V + LL++ A +
Sbjct: 437 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 496

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +  D  T L  AA+ G+ ++++LLL + A  N     G  PL IA++ GH E V  +L
Sbjct: 497 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 556

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIK 257
            + A +      G T L  AA  G   V + LL+         KNG + LH AV   N+ 
Sbjct: 557 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 616

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNERILRLLRS 294
            V LLL  G  P         P  +   +  + + RS
Sbjct: 617 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 653



 Score =  100 bits (250), Expect = 1e-21
 Identities = 78/246 (31%), Positives = 123/246 (50%), Gaps = 4/246 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+ G + + +LLL       +    +G T L VA +  ++D V+ L+ +G   +    +
Sbjct: 576 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 634

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AA+Q   +V R L  +G S    +  G T L  A+Q GH ++V  LL   AN 
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +     G T L L AQ G++ V  +L+  G  V+   + G  PL +AS  G+ ++V+ +L
Sbjct: 695 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 754

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLK--FSPTLGILKNGTSALHAAVLSGNI 256
              AD +A    G + L +AA +G+ D++  LLK   SP   +  +GT+ L  A   G I
Sbjct: 755 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIAKRLGYI 813

Query: 257 KTVALL 262
               +L
Sbjct: 814 SVTDVL 819



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 40/150 (26%), Positives = 65/150 (43%), Gaps = 32/150 (21%)

Query: 144 DGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGAD 203
           D AT+   AA+ G LD     L +G  +N   Q+G   L +AS+ GH ++V V LL    
Sbjct: 44  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV-VELLH--- 99

Query: 204 RDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLL 263
                                   KE++  + T    K G +ALH A L+G  + V  L+
Sbjct: 100 ------------------------KEIILETTT----KKGNTALHIAALAGQDEVVRELV 131

Query: 264 EAGADPSLRNKANELPAELTKNERILRLLR 293
             GA+ + +++    P  +   E  L +++
Sbjct: 132 NYGANVNAQSQKGFTPLYMAAQENHLEVVK 161


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  136 bits (342), Expect = 3e-32
 Identities = 87/265 (32%), Positives = 146/265 (55%), Gaps = 2/265 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AAR  +     +LL +   + D     G T L +AA+  +++  + L+ +GA +N   ++
Sbjct: 180 AARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A+++G+  +VR L   GA  E +TKD  T L  A++ GH+++ E LL HGA I
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
             +  +G + + +AAQG +LD +RLLL   A+++    D   PL +A+  GH  V +V+L
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAAVLSGNIK 257
            +GA  ++   +G T L  A  K +  V++ LLK   ++  + ++G + LH A   G++ 
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 418

Query: 258 TVALLLEAGADPSLRNKANELPAEL 282
            V  LL+ GA P++ N   E P  +
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHM 443



 Score =  135 bits (339), Expect = 6e-32
 Identities = 89/269 (33%), Positives = 138/269 (51%), Gaps = 2/269 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A+RRGN+ +++LLL+ G   ++ +     T L  AA  GH+     L+  GA I  + ++
Sbjct: 246 ASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G + +  AAQ  H D VR L  + A  +  T D  T L  A+  GH +V + LL  GA  
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +  +G T L +A +  ++ V+ LLL +GA ++   + G  PL +AS MGH  +V+ +L
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
            RGA  + +     T L  AA  G+ +V K LL+    +    K+  + LH A   G+  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNE 286
            V LLLE  A+P+L   A   P  +   E
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAARE 513



 Score =  122 bits (307), Expect = 3e-28
 Identities = 92/283 (32%), Positives = 144/283 (50%), Gaps = 5/283 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+  +L  ++LLL       D    H  T L VAA+ GH    + L+ +GA  N +  +
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A ++ H  V+  L   GAS +  T+ G T L  AS  GH+ +V+ LL+ GA+ 
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +       T L +AA+ G+ +V + LL + AKVN   +D   PL  A+++GH+ +V+++L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELL-KFSPTLGILKNGTSALHAAVLSGNIK 257
              A+ + A   G T L  AA +G+ + +  LL K +    + K G + LH A   G ++
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550

Query: 258 TVALLLEAGADPSLRNKANELPAELT---KNERILRLLRSKEG 297
              LLLE  A P+   K    P  +     N  I++LL  + G
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593



 Score =  119 bits (297), Expect = 4e-27
 Identities = 91/290 (31%), Positives = 143/290 (49%), Gaps = 10/290 (3%)

Query: 7   KKETPLANAAFWAARRGNLALLKLLL-NSGRVDVDCRDSHGTTLLMVAAYAGHIDCVREL 65
           K ETPL      AAR G+  + K LL N  +V+   +D    T L  AA  GH + V+ L
Sbjct: 436 KVETPL----HMAARAGHTEVAKYLLQNKAKVNAKAKDDQ--TPLHCAARIGHTNMVKLL 489

Query: 66  VLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHM 125
           +   A+ NL   +G T L  AA++GH + V  L    AS    TK G T L  A++YG +
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549

Query: 126 QVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIA 185
           +V E LL+  A+ +    +G T L +A     LD+++LLL  G   + P  +G  PL IA
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609

Query: 186 SQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELL--KFSPTLGILKNG 243
           ++    EV R +L  G   +A    G T L  AA +G+ +++  LL  + +  LG  K+G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG-NKSG 668

Query: 244 TSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLR 293
            + LH     G++    +L++ G       +    P  +  +   ++L++
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 718



 Score =  114 bits (285), Expect = 1e-25
 Identities = 88/307 (28%), Positives = 146/307 (47%), Gaps = 34/307 (11%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G   +++ L+N G  +V+ +   G T L +AA   H++ V+ L+  GA+ N+  E 
Sbjct: 85  AALAGQDEVVRELVNYG-ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED 143

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFR-----------------------------T 109
           G T L  A QQGH +VV  L  +G   + R                             +
Sbjct: 144 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 110 KDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGA 169
           K G T L  A+ Y ++ V + LL  GA+++    +G T L +A++ G + ++RLLL  GA
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263

Query: 170 KVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKE 229
           ++    +D   PL  A++ GH  +  ++L  GA   A   +G + +  AA   + D ++ 
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 230 LLKFSPTL-GILKNGTSALHAAVLSGNIKTVALLLEAGADPSLR--NKANELPAELTKNE 286
           LL++   +  I  +  + LH A   G+ +   +LL+ GA P+ R  N    L     KN 
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383

Query: 287 -RILRLL 292
            R++ LL
Sbjct: 384 VRVMELL 390



 Score =  113 bits (282), Expect = 2e-25
 Identities = 87/271 (32%), Positives = 128/271 (47%), Gaps = 30/271 (11%)

Query: 39  VDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFL 98
           V  R++   T  + AA +G++D   + +  G DIN   ++G   L  A+++GH  +V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 99  FGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYL 158
                  E  TK G TAL  A+  G  +VV  L+ +GAN++ Q   G T L++AAQ  +L
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 159 DVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRG--------ADRDAARND 210
           +V++ LL +GA  N   +DG  PL +A Q GH  VV  ++  G        A   AARND
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184

Query: 211 GT-TALLKAANKGYNDVIKE--------------------LLKFSPTLGIL-KNGTSALH 248
            T TA +   N    DV+ +                    LL    ++    +NG + LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244

Query: 249 AAVLSGNIKTVALLLEAGADPSLRNKANELP 279
            A   GN+  V LLL+ GA    + K    P
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTP 275



 Score =  110 bits (276), Expect = 1e-24
 Identities = 82/267 (30%), Positives = 125/267 (46%), Gaps = 2/267 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AAR G++  +  LL        C    G T L VAA  G +     L+ + A  N   ++
Sbjct: 510 AAREGHVETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A    + D+V+ L   G S      +G T L  A++   ++V  +LL++G + 
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +   G T L LAAQ G+ +++ LLL+  A  N   + G  PL + +Q GH  V  V++
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
             G   DA    G T L  A++ G   ++K LL+    +    K G S LH A   G+  
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTD 748

Query: 258 TVALLLEAGADPSLRNKANELPAELTK 284
            V LLL+ GA P+  +     P  + K
Sbjct: 749 IVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score =  110 bits (275), Expect = 2e-24
 Identities = 72/213 (33%), Positives = 106/213 (49%), Gaps = 4/213 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A    NL ++KLLL  G         +G T L +AA    ++  R L+  G   N +   
Sbjct: 576 AVHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AAQ+GH ++V  L    A+     K G T L   +Q GH+ V + L+KHG  +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
                 G T L +A+  G + +++ LL   A VN   + G +PL  A+Q GH+++V ++L
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754

Query: 199 LRGADRDAARNDGTTALLKAANKGY---NDVIK 228
             GA  +   +DGTT L  A   GY    DV+K
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787



 Score =  110 bits (274), Expect = 2e-24
 Identities = 87/277 (31%), Positives = 130/277 (46%), Gaps = 2/277 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G+  + K+LL+ G    + R  +G T L +A    H+  +  L+  GA I+   ES
Sbjct: 345 AAHCGHHRVAKVLLDKG-AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES 403

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A+  GH  +V+ L   GAS         T L  A++ GH +V + LL++ A +
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +  D  T L  AA+ G+ ++++LLL + A  N     G  PL IA++ GH E V  +L
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIK 257
            + A +      G T L  AA  G   V + LL+         KNG + LH AV   N+ 
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNERILRLLRS 294
            V LLL  G  P         P  +   +  + + RS
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620



 Score =  100 bits (250), Expect = 1e-21
 Identities = 78/246 (31%), Positives = 123/246 (50%), Gaps = 4/246 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+ G + + +LLL       +    +G T L VA +  ++D V+ L+ +G   +    +
Sbjct: 543 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AA+Q   +V R L  +G S    +  G T L  A+Q GH ++V  LL   AN 
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +     G T L L AQ G++ V  +L+  G  V+   + G  PL +AS  G+ ++V+ +L
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLK--FSPTLGILKNGTSALHAAVLSGNI 256
              AD +A    G + L +AA +G+ D++  LLK   SP   +  +GT+ L  A   G I
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIAKRLGYI 780

Query: 257 KTVALL 262
               +L
Sbjct: 781 SVTDVL 786



 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 53/196 (27%), Positives = 92/196 (46%), Gaps = 1/196 (0%)

Query: 104 STEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRL 163
           S  FR  D  T+ L A++ G++      L++G +I+    +G   L LA++ G++ ++  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 164 LLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGY 223
           LL     +    + G   L IA+  G  EVVR ++  GA+ +A    G T L  AA + +
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 224 NDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
            +V+K LL+      +  ++G + L  A+  G+   VA L+  G    +R  A  + A  
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 283 TKNERILRLLRSKEGP 298
                   LL++   P
Sbjct: 184 DDTRTAAVLLQNDPNP 199


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  136 bits (342), Expect = 3e-32
 Identities = 87/265 (32%), Positives = 146/265 (55%), Gaps = 2/265 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AAR  +     +LL +   + D     G T L +AA+  +++  + L+ +GA +N   ++
Sbjct: 180 AARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A+++G+  +VR L   GA  E +TKD  T L  A++ GH+++ E LL HGA I
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
             +  +G + + +AAQG +LD +RLLL   A+++    D   PL +A+  GH  V +V+L
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAAVLSGNIK 257
            +GA  ++   +G T L  A  K +  V++ LLK   ++  + ++G + LH A   G++ 
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 418

Query: 258 TVALLLEAGADPSLRNKANELPAEL 282
            V  LL+ GA P++ N   E P  +
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHM 443



 Score =  135 bits (339), Expect = 6e-32
 Identities = 89/269 (33%), Positives = 138/269 (51%), Gaps = 2/269 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A+RRGN+ +++LLL+ G   ++ +     T L  AA  GH+     L+  GA I  + ++
Sbjct: 246 ASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G + +  AAQ  H D VR L  + A  +  T D  T L  A+  GH +V + LL  GA  
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +  +G T L +A +  ++ V+ LLL +GA ++   + G  PL +AS MGH  +V+ +L
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
            RGA  + +     T L  AA  G+ +V K LL+    +    K+  + LH A   G+  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNE 286
            V LLLE  A+P+L   A   P  +   E
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAARE 513



 Score =  122 bits (307), Expect = 3e-28
 Identities = 92/283 (32%), Positives = 144/283 (50%), Gaps = 5/283 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+  +L  ++LLL       D    H  T L VAA+ GH    + L+ +GA  N +  +
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A ++ H  V+  L   GAS +  T+ G T L  AS  GH+ +V+ LL+ GA+ 
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +       T L +AA+ G+ +V + LL + AKVN   +D   PL  A+++GH+ +V+++L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELL-KFSPTLGILKNGTSALHAAVLSGNIK 257
              A+ + A   G T L  AA +G+ + +  LL K +    + K G + LH A   G ++
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550

Query: 258 TVALLLEAGADPSLRNKANELPAELT---KNERILRLLRSKEG 297
              LLLE  A P+   K    P  +     N  I++LL  + G
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593



 Score =  119 bits (297), Expect = 4e-27
 Identities = 91/290 (31%), Positives = 143/290 (49%), Gaps = 10/290 (3%)

Query: 7   KKETPLANAAFWAARRGNLALLKLLL-NSGRVDVDCRDSHGTTLLMVAAYAGHIDCVREL 65
           K ETPL      AAR G+  + K LL N  +V+   +D    T L  AA  GH + V+ L
Sbjct: 436 KVETPL----HMAARAGHTEVAKYLLQNKAKVNAKAKDDQ--TPLHCAARIGHTNMVKLL 489

Query: 66  VLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHM 125
           +   A+ NL   +G T L  AA++GH + V  L    AS    TK G T L  A++YG +
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549

Query: 126 QVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIA 185
           +V E LL+  A+ +    +G T L +A     LD+++LLL  G   + P  +G  PL IA
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609

Query: 186 SQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELL--KFSPTLGILKNG 243
           ++    EV R +L  G   +A    G T L  AA +G+ +++  LL  + +  LG  K+G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG-NKSG 668

Query: 244 TSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLR 293
            + LH     G++    +L++ G       +    P  +  +   ++L++
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 718



 Score =  114 bits (285), Expect = 1e-25
 Identities = 88/307 (28%), Positives = 146/307 (47%), Gaps = 34/307 (11%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G   +++ L+N G  +V+ +   G T L +AA   H++ V+ L+  GA+ N+  E 
Sbjct: 85  AALAGQDEVVRELVNYG-ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED 143

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFR-----------------------------T 109
           G T L  A QQGH +VV  L  +G   + R                             +
Sbjct: 144 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 110 KDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGA 169
           K G T L  A+ Y ++ V + LL  GA+++    +G T L +A++ G + ++RLLL  GA
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263

Query: 170 KVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKE 229
           ++    +D   PL  A++ GH  +  ++L  GA   A   +G + +  AA   + D ++ 
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 230 LLKFSPTL-GILKNGTSALHAAVLSGNIKTVALLLEAGADPSLR--NKANELPAELTKNE 286
           LL++   +  I  +  + LH A   G+ +   +LL+ GA P+ R  N    L     KN 
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383

Query: 287 -RILRLL 292
            R++ LL
Sbjct: 384 VRVMELL 390



 Score =  113 bits (282), Expect = 2e-25
 Identities = 87/271 (32%), Positives = 128/271 (47%), Gaps = 30/271 (11%)

Query: 39  VDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFL 98
           V  R++   T  + AA +G++D   + +  G DIN   ++G   L  A+++GH  +V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 99  FGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYL 158
                  E  TK G TAL  A+  G  +VV  L+ +GAN++ Q   G T L++AAQ  +L
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 159 DVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRG--------ADRDAARND 210
           +V++ LL +GA  N   +DG  PL +A Q GH  VV  ++  G        A   AARND
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184

Query: 211 GT-TALLKAANKGYNDVIKE--------------------LLKFSPTLGIL-KNGTSALH 248
            T TA +   N    DV+ +                    LL    ++    +NG + LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244

Query: 249 AAVLSGNIKTVALLLEAGADPSLRNKANELP 279
            A   GN+  V LLL+ GA    + K    P
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTP 275



 Score =  110 bits (276), Expect = 1e-24
 Identities = 82/267 (30%), Positives = 125/267 (46%), Gaps = 2/267 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AAR G++  +  LL        C    G T L VAA  G +     L+ + A  N   ++
Sbjct: 510 AAREGHVETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A    + D+V+ L   G S      +G T L  A++   ++V  +LL++G + 
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +   G T L LAAQ G+ +++ LLL+  A  N   + G  PL + +Q GH  V  V++
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
             G   DA    G T L  A++ G   ++K LL+    +    K G S LH A   G+  
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTD 748

Query: 258 TVALLLEAGADPSLRNKANELPAELTK 284
            V LLL+ GA P+  +     P  + K
Sbjct: 749 IVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score =  110 bits (275), Expect = 2e-24
 Identities = 72/213 (33%), Positives = 106/213 (49%), Gaps = 4/213 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A    NL ++KLLL  G         +G T L +AA    ++  R L+  G   N +   
Sbjct: 576 AVHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AAQ+GH ++V  L    A+     K G T L   +Q GH+ V + L+KHG  +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
                 G T L +A+  G + +++ LL   A VN   + G +PL  A+Q GH+++V ++L
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754

Query: 199 LRGADRDAARNDGTTALLKAANKGY---NDVIK 228
             GA  +   +DGTT L  A   GY    DV+K
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787



 Score =  110 bits (274), Expect = 2e-24
 Identities = 87/277 (31%), Positives = 130/277 (46%), Gaps = 2/277 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G+  + K+LL+ G    + R  +G T L +A    H+  +  L+  GA I+   ES
Sbjct: 345 AAHCGHHRVAKVLLDKG-AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES 403

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A+  GH  +V+ L   GAS         T L  A++ GH +V + LL++ A +
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +  D  T L  AA+ G+ ++++LLL + A  N     G  PL IA++ GH E V  +L
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIK 257
            + A +      G T L  AA  G   V + LL+         KNG + LH AV   N+ 
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNERILRLLRS 294
            V LLL  G  P         P  +   +  + + RS
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620



 Score =  100 bits (250), Expect = 1e-21
 Identities = 78/246 (31%), Positives = 123/246 (50%), Gaps = 4/246 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+ G + + +LLL       +    +G T L VA +  ++D V+ L+ +G   +    +
Sbjct: 543 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AA+Q   +V R L  +G S    +  G T L  A+Q GH ++V  LL   AN 
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +     G T L L AQ G++ V  +L+  G  V+   + G  PL +AS  G+ ++V+ +L
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLK--FSPTLGILKNGTSALHAAVLSGNI 256
              AD +A    G + L +AA +G+ D++  LLK   SP   +  +GT+ L  A   G I
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIAKRLGYI 780

Query: 257 KTVALL 262
               +L
Sbjct: 781 SVTDVL 786



 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 53/196 (27%), Positives = 92/196 (46%), Gaps = 1/196 (0%)

Query: 104 STEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRL 163
           S  FR  D  T+ L A++ G++      L++G +I+    +G   L LA++ G++ ++  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 164 LLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGY 223
           LL     +    + G   L IA+  G  EVVR ++  GA+ +A    G T L  AA + +
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 224 NDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
            +V+K LL+      +  ++G + L  A+  G+   VA L+  G    +R  A  + A  
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 283 TKNERILRLLRSKEGP 298
                   LL++   P
Sbjct: 184 DDTRTAAVLLQNDPNP 199


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  136 bits (342), Expect = 3e-32
 Identities = 87/265 (32%), Positives = 146/265 (55%), Gaps = 2/265 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AAR  +     +LL +   + D     G T L +AA+  +++  + L+ +GA +N   ++
Sbjct: 180 AARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A+++G+  +VR L   GA  E +TKD  T L  A++ GH+++ E LL HGA I
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
             +  +G + + +AAQG +LD +RLLL   A+++    D   PL +A+  GH  V +V+L
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAAVLSGNIK 257
            +GA  ++   +G T L  A  K +  V++ LLK   ++  + ++G + LH A   G++ 
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 418

Query: 258 TVALLLEAGADPSLRNKANELPAEL 282
            V  LL+ GA P++ N   E P  +
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHM 443



 Score =  135 bits (339), Expect = 6e-32
 Identities = 89/269 (33%), Positives = 138/269 (51%), Gaps = 2/269 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A+RRGN+ +++LLL+ G   ++ +     T L  AA  GH+     L+  GA I  + ++
Sbjct: 246 ASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G + +  AAQ  H D VR L  + A  +  T D  T L  A+  GH +V + LL  GA  
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +  +G T L +A +  ++ V+ LLL +GA ++   + G  PL +AS MGH  +V+ +L
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
            RGA  + +     T L  AA  G+ +V K LL+    +    K+  + LH A   G+  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNE 286
            V LLLE  A+P+L   A   P  +   E
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAARE 513



 Score =  122 bits (307), Expect = 3e-28
 Identities = 92/283 (32%), Positives = 144/283 (50%), Gaps = 5/283 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+  +L  ++LLL       D    H  T L VAA+ GH    + L+ +GA  N +  +
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A ++ H  V+  L   GAS +  T+ G T L  AS  GH+ +V+ LL+ GA+ 
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +       T L +AA+ G+ +V + LL + AKVN   +D   PL  A+++GH+ +V+++L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELL-KFSPTLGILKNGTSALHAAVLSGNIK 257
              A+ + A   G T L  AA +G+ + +  LL K +    + K G + LH A   G ++
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550

Query: 258 TVALLLEAGADPSLRNKANELPAELT---KNERILRLLRSKEG 297
              LLLE  A P+   K    P  +     N  I++LL  + G
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593



 Score =  119 bits (297), Expect = 4e-27
 Identities = 91/290 (31%), Positives = 143/290 (49%), Gaps = 10/290 (3%)

Query: 7   KKETPLANAAFWAARRGNLALLKLLL-NSGRVDVDCRDSHGTTLLMVAAYAGHIDCVREL 65
           K ETPL      AAR G+  + K LL N  +V+   +D    T L  AA  GH + V+ L
Sbjct: 436 KVETPL----HMAARAGHTEVAKYLLQNKAKVNAKAKDDQ--TPLHCAARIGHTNMVKLL 489

Query: 66  VLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHM 125
           +   A+ NL   +G T L  AA++GH + V  L    AS    TK G T L  A++YG +
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549

Query: 126 QVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIA 185
           +V E LL+  A+ +    +G T L +A     LD+++LLL  G   + P  +G  PL IA
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609

Query: 186 SQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELL--KFSPTLGILKNG 243
           ++    EV R +L  G   +A    G T L  AA +G+ +++  LL  + +  LG  K+G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG-NKSG 668

Query: 244 TSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLR 293
            + LH     G++    +L++ G       +    P  +  +   ++L++
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 718



 Score =  114 bits (285), Expect = 1e-25
 Identities = 88/307 (28%), Positives = 146/307 (47%), Gaps = 34/307 (11%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G   +++ L+N G  +V+ +   G T L +AA   H++ V+ L+  GA+ N+  E 
Sbjct: 85  AALAGQDEVVRELVNYG-ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED 143

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFR-----------------------------T 109
           G T L  A QQGH +VV  L  +G   + R                             +
Sbjct: 144 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 110 KDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGA 169
           K G T L  A+ Y ++ V + LL  GA+++    +G T L +A++ G + ++RLLL  GA
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263

Query: 170 KVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKE 229
           ++    +D   PL  A++ GH  +  ++L  GA   A   +G + +  AA   + D ++ 
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 230 LLKFSPTL-GILKNGTSALHAAVLSGNIKTVALLLEAGADPSLR--NKANELPAELTKNE 286
           LL++   +  I  +  + LH A   G+ +   +LL+ GA P+ R  N    L     KN 
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383

Query: 287 -RILRLL 292
            R++ LL
Sbjct: 384 VRVMELL 390



 Score =  113 bits (282), Expect = 2e-25
 Identities = 87/271 (32%), Positives = 128/271 (47%), Gaps = 30/271 (11%)

Query: 39  VDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFL 98
           V  R++   T  + AA +G++D   + +  G DIN   ++G   L  A+++GH  +V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 99  FGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYL 158
                  E  TK G TAL  A+  G  +VV  L+ +GAN++ Q   G T L++AAQ  +L
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 159 DVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRG--------ADRDAARND 210
           +V++ LL +GA  N   +DG  PL +A Q GH  VV  ++  G        A   AARND
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184

Query: 211 GT-TALLKAANKGYNDVIKE--------------------LLKFSPTLGIL-KNGTSALH 248
            T TA +   N    DV+ +                    LL    ++    +NG + LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244

Query: 249 AAVLSGNIKTVALLLEAGADPSLRNKANELP 279
            A   GN+  V LLL+ GA    + K    P
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTP 275



 Score =  110 bits (276), Expect = 1e-24
 Identities = 82/267 (30%), Positives = 125/267 (46%), Gaps = 2/267 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AAR G++  +  LL        C    G T L VAA  G +     L+ + A  N   ++
Sbjct: 510 AAREGHVETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A    + D+V+ L   G S      +G T L  A++   ++V  +LL++G + 
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +   G T L LAAQ G+ +++ LLL+  A  N   + G  PL + +Q GH  V  V++
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
             G   DA    G T L  A++ G   ++K LL+    +    K G S LH A   G+  
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTD 748

Query: 258 TVALLLEAGADPSLRNKANELPAELTK 284
            V LLL+ GA P+  +     P  + K
Sbjct: 749 IVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score =  110 bits (275), Expect = 2e-24
 Identities = 72/213 (33%), Positives = 106/213 (49%), Gaps = 4/213 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A    NL ++KLLL  G         +G T L +AA    ++  R L+  G   N +   
Sbjct: 576 AVHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AAQ+GH ++V  L    A+     K G T L   +Q GH+ V + L+KHG  +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
                 G T L +A+  G + +++ LL   A VN   + G +PL  A+Q GH+++V ++L
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754

Query: 199 LRGADRDAARNDGTTALLKAANKGY---NDVIK 228
             GA  +   +DGTT L  A   GY    DV+K
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787



 Score =  110 bits (274), Expect = 2e-24
 Identities = 87/277 (31%), Positives = 130/277 (46%), Gaps = 2/277 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G+  + K+LL+ G    + R  +G T L +A    H+  +  L+  GA I+   ES
Sbjct: 345 AAHCGHHRVAKVLLDKG-AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES 403

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A+  GH  +V+ L   GAS         T L  A++ GH +V + LL++ A +
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +  D  T L  AA+ G+ ++++LLL + A  N     G  PL IA++ GH E V  +L
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIK 257
            + A +      G T L  AA  G   V + LL+         KNG + LH AV   N+ 
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNERILRLLRS 294
            V LLL  G  P         P  +   +  + + RS
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620



 Score =  100 bits (250), Expect = 1e-21
 Identities = 78/246 (31%), Positives = 123/246 (50%), Gaps = 4/246 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+ G + + +LLL       +    +G T L VA +  ++D V+ L+ +G   +    +
Sbjct: 543 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AA+Q   +V R L  +G S    +  G T L  A+Q GH ++V  LL   AN 
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +     G T L L AQ G++ V  +L+  G  V+   + G  PL +AS  G+ ++V+ +L
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLK--FSPTLGILKNGTSALHAAVLSGNI 256
              AD +A    G + L +AA +G+ D++  LLK   SP   +  +GT+ L  A   G I
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIAKRLGYI 780

Query: 257 KTVALL 262
               +L
Sbjct: 781 SVTDVL 786



 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 53/196 (27%), Positives = 92/196 (46%), Gaps = 1/196 (0%)

Query: 104 STEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRL 163
           S  FR  D  T+ L A++ G++      L++G +I+    +G   L LA++ G++ ++  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 164 LLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGY 223
           LL     +    + G   L IA+  G  EVVR ++  GA+ +A    G T L  AA + +
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 224 NDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
            +V+K LL+      +  ++G + L  A+  G+   VA L+  G    +R  A  + A  
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 283 TKNERILRLLRSKEGP 298
                   LL++   P
Sbjct: 184 DDTRTAAVLLQNDPNP 199


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  136 bits (342), Expect = 3e-32
 Identities = 87/265 (32%), Positives = 146/265 (55%), Gaps = 2/265 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AAR  +     +LL +   + D     G T L +AA+  +++  + L+ +GA +N   ++
Sbjct: 180 AARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A+++G+  +VR L   GA  E +TKD  T L  A++ GH+++ E LL HGA I
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
             +  +G + + +AAQG +LD +RLLL   A+++    D   PL +A+  GH  V +V+L
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAAVLSGNIK 257
            +GA  ++   +G T L  A  K +  V++ LLK   ++  + ++G + LH A   G++ 
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 418

Query: 258 TVALLLEAGADPSLRNKANELPAEL 282
            V  LL+ GA P++ N   E P  +
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHM 443



 Score =  135 bits (339), Expect = 6e-32
 Identities = 89/269 (33%), Positives = 138/269 (51%), Gaps = 2/269 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A+RRGN+ +++LLL+ G   ++ +     T L  AA  GH+     L+  GA I  + ++
Sbjct: 246 ASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G + +  AAQ  H D VR L  + A  +  T D  T L  A+  GH +V + LL  GA  
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +  +G T L +A +  ++ V+ LLL +GA ++   + G  PL +AS MGH  +V+ +L
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
            RGA  + +     T L  AA  G+ +V K LL+    +    K+  + LH A   G+  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNE 286
            V LLLE  A+P+L   A   P  +   E
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAARE 513



 Score =  122 bits (307), Expect = 3e-28
 Identities = 92/283 (32%), Positives = 144/283 (50%), Gaps = 5/283 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+  +L  ++LLL       D    H  T L VAA+ GH    + L+ +GA  N +  +
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A ++ H  V+  L   GAS +  T+ G T L  AS  GH+ +V+ LL+ GA+ 
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +       T L +AA+ G+ +V + LL + AKVN   +D   PL  A+++GH+ +V+++L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELL-KFSPTLGILKNGTSALHAAVLSGNIK 257
              A+ + A   G T L  AA +G+ + +  LL K +    + K G + LH A   G ++
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550

Query: 258 TVALLLEAGADPSLRNKANELPAELT---KNERILRLLRSKEG 297
              LLLE  A P+   K    P  +     N  I++LL  + G
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593



 Score =  119 bits (297), Expect = 4e-27
 Identities = 91/290 (31%), Positives = 143/290 (49%), Gaps = 10/290 (3%)

Query: 7   KKETPLANAAFWAARRGNLALLKLLL-NSGRVDVDCRDSHGTTLLMVAAYAGHIDCVREL 65
           K ETPL      AAR G+  + K LL N  +V+   +D    T L  AA  GH + V+ L
Sbjct: 436 KVETPL----HMAARAGHTEVAKYLLQNKAKVNAKAKDDQ--TPLHCAARIGHTNMVKLL 489

Query: 66  VLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHM 125
           +   A+ NL   +G T L  AA++GH + V  L    AS    TK G T L  A++YG +
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549

Query: 126 QVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIA 185
           +V E LL+  A+ +    +G T L +A     LD+++LLL  G   + P  +G  PL IA
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609

Query: 186 SQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELL--KFSPTLGILKNG 243
           ++    EV R +L  G   +A    G T L  AA +G+ +++  LL  + +  LG  K+G
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG-NKSG 668

Query: 244 TSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLR 293
            + LH     G++    +L++ G       +    P  +  +   ++L++
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 718



 Score =  114 bits (285), Expect = 1e-25
 Identities = 88/307 (28%), Positives = 146/307 (47%), Gaps = 34/307 (11%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G   +++ L+N G  +V+ +   G T L +AA   H++ V+ L+  GA+ N+  E 
Sbjct: 85  AALAGQDEVVRELVNYG-ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED 143

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFR-----------------------------T 109
           G T L  A QQGH +VV  L  +G   + R                             +
Sbjct: 144 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 110 KDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGA 169
           K G T L  A+ Y ++ V + LL  GA+++    +G T L +A++ G + ++RLLL  GA
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263

Query: 170 KVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKE 229
           ++    +D   PL  A++ GH  +  ++L  GA   A   +G + +  AA   + D ++ 
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 230 LLKFSPTL-GILKNGTSALHAAVLSGNIKTVALLLEAGADPSLR--NKANELPAELTKNE 286
           LL++   +  I  +  + LH A   G+ +   +LL+ GA P+ R  N    L     KN 
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383

Query: 287 -RILRLL 292
            R++ LL
Sbjct: 384 VRVMELL 390



 Score =  113 bits (282), Expect = 2e-25
 Identities = 87/271 (32%), Positives = 128/271 (47%), Gaps = 30/271 (11%)

Query: 39  VDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFL 98
           V  R++   T  + AA +G++D   + +  G DIN   ++G   L  A+++GH  +V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 99  FGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYL 158
                  E  TK G TAL  A+  G  +VV  L+ +GAN++ Q   G T L++AAQ  +L
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 159 DVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRG--------ADRDAARND 210
           +V++ LL +GA  N   +DG  PL +A Q GH  VV  ++  G        A   AARND
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184

Query: 211 GT-TALLKAANKGYNDVIKE--------------------LLKFSPTLGIL-KNGTSALH 248
            T TA +   N    DV+ +                    LL    ++    +NG + LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244

Query: 249 AAVLSGNIKTVALLLEAGADPSLRNKANELP 279
            A   GN+  V LLL+ GA    + K    P
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTP 275



 Score =  110 bits (276), Expect = 1e-24
 Identities = 82/267 (30%), Positives = 125/267 (46%), Gaps = 2/267 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AAR G++  +  LL        C    G T L VAA  G +     L+ + A  N   ++
Sbjct: 510 AAREGHVETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A    + D+V+ L   G S      +G T L  A++   ++V  +LL++G + 
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +   G T L LAAQ G+ +++ LLL+  A  N   + G  PL + +Q GH  V  V++
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
             G   DA    G T L  A++ G   ++K LL+    +    K G S LH A   G+  
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTD 748

Query: 258 TVALLLEAGADPSLRNKANELPAELTK 284
            V LLL+ GA P+  +     P  + K
Sbjct: 749 IVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score =  110 bits (275), Expect = 2e-24
 Identities = 72/213 (33%), Positives = 106/213 (49%), Gaps = 4/213 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A    NL ++KLLL  G         +G T L +AA    ++  R L+  G   N +   
Sbjct: 576 AVHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AAQ+GH ++V  L    A+     K G T L   +Q GH+ V + L+KHG  +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
                 G T L +A+  G + +++ LL   A VN   + G +PL  A+Q GH+++V ++L
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754

Query: 199 LRGADRDAARNDGTTALLKAANKGY---NDVIK 228
             GA  +   +DGTT L  A   GY    DV+K
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787



 Score =  110 bits (274), Expect = 2e-24
 Identities = 87/277 (31%), Positives = 130/277 (46%), Gaps = 2/277 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G+  + K+LL+ G    + R  +G T L +A    H+  +  L+  GA I+   ES
Sbjct: 345 AAHCGHHRVAKVLLDKG-AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES 403

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A+  GH  +V+ L   GAS         T L  A++ GH +V + LL++ A +
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           + +  D  T L  AA+ G+ ++++LLL + A  N     G  PL IA++ GH E V  +L
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIK 257
            + A +      G T L  AA  G   V + LL+         KNG + LH AV   N+ 
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNERILRLLRS 294
            V LLL  G  P         P  +   +  + + RS
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620



 Score =  100 bits (250), Expect = 1e-21
 Identities = 78/246 (31%), Positives = 123/246 (50%), Gaps = 4/246 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+ G + + +LLL       +    +G T L VA +  ++D V+ L+ +G   +    +
Sbjct: 543 AAKYGKVRVAELLLERD-AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AA+Q   +V R L  +G S    +  G T L  A+Q GH ++V  LL   AN 
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +     G T L L AQ G++ V  +L+  G  V+   + G  PL +AS  G+ ++V+ +L
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLK--FSPTLGILKNGTSALHAAVLSGNI 256
              AD +A    G + L +AA +G+ D++  LLK   SP   +  +GT+ L  A   G I
Sbjct: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIAKRLGYI 780

Query: 257 KTVALL 262
               +L
Sbjct: 781 SVTDVL 786



 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 53/196 (27%), Positives = 92/196 (46%), Gaps = 1/196 (0%)

Query: 104 STEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRL 163
           S  FR  D  T+ L A++ G++      L++G +I+    +G   L LA++ G++ ++  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 164 LLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGY 223
           LL     +    + G   L IA+  G  EVVR ++  GA+ +A    G T L  AA + +
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 224 NDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
            +V+K LL+      +  ++G + L  A+  G+   VA L+  G    +R  A  + A  
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 283 TKNERILRLLRSKEGP 298
                   LL++   P
Sbjct: 184 DDTRTAAVLLQNDPNP 199


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  134 bits (336), Expect = 1e-31
 Identities = 93/267 (34%), Positives = 141/267 (52%), Gaps = 14/267 (5%)

Query: 42  RDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGF 101
           + S      + AA AG++D V E +  G DIN   ++G  AL  AA++GH  +V+ L G 
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 102 GASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVI 161
           G+S +  TK G TAL  AS  G  +VV+ L+K GANI+ Q  +G T L++AAQ  ++DV+
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 162 RLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML---LRGADR-----DAARNDGTT 213
           + LL +GA  +   +DG  PL +A Q GH++ V ++L    +G  R      AAR D T 
Sbjct: 147 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206

Query: 214 ALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGA--DPSL 271
           +        +N  ++  +  + T    ++G + LH A   GN+    LLL  GA  D + 
Sbjct: 207 SAALLLQNDHNADVQSKMMVNRT---TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263

Query: 272 RNKANEL-PAELTKNERILRLLRSKEG 297
           RN    L  A    N  +++LL  + G
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGG 290



 Score =  124 bits (310), Expect = 1e-28
 Identities = 83/267 (31%), Positives = 143/267 (53%), Gaps = 8/267 (2%)

Query: 19  AARRGNLALLKLLL-NSGRVDVDCR------DSHGTTLLMVAAYAGHIDCVRELVLQGAD 71
           AAR+ +     LLL N    DV  +         G T L +AA+ G+++    L+ +GA 
Sbjct: 199 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 258

Query: 72  INLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETL 131
           ++    +G T L  A+++G+ ++V+ L   G   + +T+DG T L  A++ GH QVVE L
Sbjct: 259 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318

Query: 132 LKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHS 191
           L+ GA +  +  +G + L +AAQG +++ ++ LL   A V+    D    L +A+  GH 
Sbjct: 319 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378

Query: 192 EVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAA 250
            V +++L + A+ +A   +G T L  A  K    V++ L+K+  ++  I ++G + +H A
Sbjct: 379 RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438

Query: 251 VLSGNIKTVALLLEAGADPSLRNKANE 277
              G++  V LLL+ GA P + N   E
Sbjct: 439 AFMGHLNIVLLLLQNGASPDVTNIRGE 465



 Score =  122 bits (306), Expect = 4e-28
 Identities = 94/309 (30%), Positives = 148/309 (47%), Gaps = 40/309 (12%)

Query: 13  ANAAFW-AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGAD 71
           +NA+F  AAR GNL  +   L  G +D++  + +G   L +AA  GH+  V+EL+ +G+ 
Sbjct: 31  SNASFLRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 72  INLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETL 131
           ++   + G TAL  A+  G  +VV+ L   GA+   ++++G T L  A+Q  H+ VV+ L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 132 LKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAK--------------------- 170
           L++GAN      DG T L +A Q G+   + +LL +  K                     
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209

Query: 171 ----------------VNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTA 214
                           VN+  + G  PL IA+  G+  V  ++L RGA  D    +G T 
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269

Query: 215 LLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIKTVALLLEAGADPSLRN 273
           L  A+ +G  +++K LL     +    ++G + LH A  SG+ + V LLLE GA    R 
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART 329

Query: 274 KANELPAEL 282
           K    P  +
Sbjct: 330 KNGLSPLHM 338



 Score =  120 bits (300), Expect = 2e-27
 Identities = 87/270 (32%), Positives = 135/270 (50%), Gaps = 4/270 (1%)

Query: 19  AARRGNLALLKLLLN-SGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
           A++RGN  ++KLLL+  G++D   RD  G T L  AA +GH   V  L+ +GA +  + +
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTK 330

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
           +G + L  AAQ  H + V+ L    A  +  T D  TAL  A+  GH +V + LL   AN
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVM 197
            + +  +G T L +A +   + V+ LL+  GA +    + G  P+ +A+ MGH  +V ++
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450

Query: 198 LLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNI 256
           L  GA  D     G TAL  AA  G  +V++ LL+    +    +   + LH A   G  
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 510

Query: 257 KTVALLLEAGADPSLRNKANELPAELTKNE 286
           + V LLL+  A P         P  ++  E
Sbjct: 511 EIVQLLLQHMAHPDAATTNGYTPLHISARE 540



 Score =  119 bits (298), Expect = 3e-27
 Identities = 91/274 (33%), Positives = 133/274 (48%), Gaps = 2/274 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G+  + KLLL+  R + + R  +G T L +A     I  +  LV  GA I    ES
Sbjct: 372 AAHCGHYRVTKLLLDK-RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 430

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T +  AA  GH ++V  L   GAS +     G TAL  A++ G ++VV  LL++GA +
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
             +  +  T L +A++ G  ++++LLL   A  +    +G  PL I+++ G  +V  V+L
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIK 257
             GA    A   G T L  AA  G  DV K LL+         KNG + LH A    N K
Sbjct: 551 EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 610

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNERILRL 291
              LLLE GA P    K    P  +   +  +++
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644



 Score =  117 bits (293), Expect = 1e-26
 Identities = 92/281 (32%), Positives = 147/281 (52%), Gaps = 5/281 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+  ++  +K LL   +  VD       T L VAA+ GH    + L+ + A+ N +  +
Sbjct: 339 AAQGDHVECVKHLLQH-KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN 397

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A ++    V+  L  +GAS +  T+ G T +  A+  GH+ +V  LL++GA+ 
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
                 G TAL +AA+ G ++V+R LL +GA V+   ++   PL IAS++G +E+V+++L
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
              A  DAA  +G T L  +A +G  DV   LL+      +  K G + LH A   G++ 
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 577

Query: 258 TVALLLE--AGADPSLRNKANEL-PAELTKNERILRLLRSK 295
              LLL+  A AD + +N    L  A    N+++  LL  K
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 618



 Score =  115 bits (289), Expect = 4e-26
 Identities = 84/292 (28%), Positives = 137/292 (46%), Gaps = 39/292 (13%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A+  G   ++K+L+  G  +++ +  +G T L +AA   HID V+ L+  GA+ +   E 
Sbjct: 104 ASLAGQAEVVKVLVKEG-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATED 162

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFR------------------------------ 108
           G T L  A QQGHN  V  L       + R                              
Sbjct: 163 GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQS 222

Query: 109 -------TKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVI 161
                  T+ G T L  A+ YG++ V   LL  GA +     +G T L +A++ G  +++
Sbjct: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 282

Query: 162 RLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANK 221
           +LLL  G +++   +DG  PL  A++ GH +VV ++L RGA   A   +G + L  AA  
Sbjct: 283 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 342

Query: 222 GYNDVIKELLKF-SPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADPSLR 272
            + + +K LL+  +P   +  +  +ALH A   G+ +   LLL+  A+P+ R
Sbjct: 343 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 394



 Score =  115 bits (288), Expect = 5e-26
 Identities = 87/278 (31%), Positives = 135/278 (48%), Gaps = 6/278 (2%)

Query: 10  TPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQG 69
           TP+  AAF     G+L ++ LLL +G    D  +  G T L +AA AG ++ VR L+  G
Sbjct: 433 TPIHVAAFM----GHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487

Query: 70  ADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVE 129
           A ++ +     T L  A++ G  ++V+ L    A  +  T +G T L  +++ G + V  
Sbjct: 488 ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVAS 547

Query: 130 TLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMG 189
            LL+ GA        G T L +AA+ G LDV +LLL   A  +   ++G  PL +A+   
Sbjct: 548 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 607

Query: 190 HSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALH 248
           + +V  ++L +GA   A   +G T L  AA K    +   LL +     I+ K G + LH
Sbjct: 608 NQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 667

Query: 249 AAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNE 286
            A   G+   V LLL+ GA+  +  K+      L   E
Sbjct: 668 LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705



 Score =  115 bits (287), Expect = 6e-26
 Identities = 81/253 (32%), Positives = 123/253 (48%), Gaps = 2/253 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           +AR G + +  +LL +G          G T L VAA  G +D  + L+ + A  +   ++
Sbjct: 537 SAREGQVDVASVLLEAGAAH-SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 595

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AA   +  V   L   GAS     K+G T L  A++   MQ+  TLL +GA  
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +     G T L LA+Q G+ D++ LLL  GA ++   + G   L +A+Q     V  ++ 
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILT 715

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
             GAD+DA    G T L+ A + G   ++  LLK    +    KNG + LH A   G+  
Sbjct: 716 KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTH 775

Query: 258 TVALLLEAGADPS 270
            + +LL+ GA P+
Sbjct: 776 IINVLLQHGAKPN 788



 Score =  114 bits (285), Expect = 1e-25
 Identities = 85/245 (34%), Positives = 123/245 (50%), Gaps = 2/245 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+ G+L + KLLL   R   D    +G T L VAA+  +      L+ +GA  +   ++
Sbjct: 570 AAKYGSLDVAKLLLQR-RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AA++    +   L  +GA T   TK G T L  ASQ GH  +V  LL  GANI
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           H     G T+L LAAQ   ++V  +L   GA  +   + G  PL +A   G+ ++V  +L
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKF-SPTLGILKNGTSALHAAVLSGNIK 257
            +GA+ +A   +G T L +AA +G+  +I  LL+  +       NG +AL  A   G I 
Sbjct: 749 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYIS 808

Query: 258 TVALL 262
            V  L
Sbjct: 809 VVDTL 813



 Score =  111 bits (278), Expect = 7e-25
 Identities = 86/274 (31%), Positives = 136/274 (49%), Gaps = 6/274 (2%)

Query: 7   KKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV 66
           +++TPL      A+R G   +++LLL       D   ++G T L ++A  G +D    L+
Sbjct: 496 EEQTPL----HIASRLGKTEIVQLLLQH-MAHPDAATTNGYTPLHISAREGQVDVASVLL 550

Query: 67  LQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQ 126
             GA  +L  + G T L  AA+ G  DV + L    A+ +   K+G T L  A+ Y + +
Sbjct: 551 EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 610

Query: 127 VVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIAS 186
           V   LL+ GA+ H    +G T L +AA+   + +   LL  GA+ N   + G  PL +AS
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670

Query: 187 QMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTS 245
           Q GH+++V ++L +GA+   +   G T+L  AA +   +V   L K         K G +
Sbjct: 671 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730

Query: 246 ALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
            L  A   GN+K V  LL+ GA+ + + K    P
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 764


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  134 bits (336), Expect = 1e-31
 Identities = 93/267 (34%), Positives = 141/267 (52%), Gaps = 14/267 (5%)

Query: 42  RDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGF 101
           + S      + AA AG++D V E +  G DIN   ++G  AL  AA++GH  +V+ L G 
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 102 GASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVI 161
           G+S +  TK G TAL  AS  G  +VV+ L+K GANI+ Q  +G T L++AAQ  ++DV+
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 162 RLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML---LRGADR-----DAARNDGTT 213
           + LL +GA  +   +DG  PL +A Q GH++ V ++L    +G  R      AAR D T 
Sbjct: 147 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206

Query: 214 ALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGA--DPSL 271
           +        +N  ++  +  + T    ++G + LH A   GN+    LLL  GA  D + 
Sbjct: 207 SAALLLQNDHNADVQSKMMVNRT---TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263

Query: 272 RNKANEL-PAELTKNERILRLLRSKEG 297
           RN    L  A    N  +++LL  + G
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGG 290



 Score =  124 bits (310), Expect = 1e-28
 Identities = 83/267 (31%), Positives = 143/267 (53%), Gaps = 8/267 (2%)

Query: 19  AARRGNLALLKLLL-NSGRVDVDCR------DSHGTTLLMVAAYAGHIDCVRELVLQGAD 71
           AAR+ +     LLL N    DV  +         G T L +AA+ G+++    L+ +GA 
Sbjct: 199 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 258

Query: 72  INLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETL 131
           ++    +G T L  A+++G+ ++V+ L   G   + +T+DG T L  A++ GH QVVE L
Sbjct: 259 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318

Query: 132 LKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHS 191
           L+ GA +  +  +G + L +AAQG +++ ++ LL   A V+    D    L +A+  GH 
Sbjct: 319 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378

Query: 192 EVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAA 250
            V +++L + A+ +A   +G T L  A  K    V++ L+K+  ++  I ++G + +H A
Sbjct: 379 RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438

Query: 251 VLSGNIKTVALLLEAGADPSLRNKANE 277
              G++  V LLL+ GA P + N   E
Sbjct: 439 AFMGHLNIVLLLLQNGASPDVTNIRGE 465



 Score =  122 bits (306), Expect = 4e-28
 Identities = 94/309 (30%), Positives = 148/309 (47%), Gaps = 40/309 (12%)

Query: 13  ANAAFW-AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGAD 71
           +NA+F  AAR GNL  +   L  G +D++  + +G   L +AA  GH+  V+EL+ +G+ 
Sbjct: 31  SNASFLRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 72  INLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETL 131
           ++   + G TAL  A+  G  +VV+ L   GA+   ++++G T L  A+Q  H+ VV+ L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 132 LKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAK--------------------- 170
           L++GAN      DG T L +A Q G+   + +LL +  K                     
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209

Query: 171 ----------------VNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTA 214
                           VN+  + G  PL IA+  G+  V  ++L RGA  D    +G T 
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269

Query: 215 LLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIKTVALLLEAGADPSLRN 273
           L  A+ +G  +++K LL     +    ++G + LH A  SG+ + V LLLE GA    R 
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART 329

Query: 274 KANELPAEL 282
           K    P  +
Sbjct: 330 KNGLSPLHM 338



 Score =  120 bits (300), Expect = 2e-27
 Identities = 87/270 (32%), Positives = 135/270 (50%), Gaps = 4/270 (1%)

Query: 19  AARRGNLALLKLLLN-SGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
           A++RGN  ++KLLL+  G++D   RD  G T L  AA +GH   V  L+ +GA +  + +
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTK 330

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
           +G + L  AAQ  H + V+ L    A  +  T D  TAL  A+  GH +V + LL   AN
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVM 197
            + +  +G T L +A +   + V+ LL+  GA +    + G  P+ +A+ MGH  +V ++
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450

Query: 198 LLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNI 256
           L  GA  D     G TAL  AA  G  +V++ LL+    +    +   + LH A   G  
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 510

Query: 257 KTVALLLEAGADPSLRNKANELPAELTKNE 286
           + V LLL+  A P         P  ++  E
Sbjct: 511 EIVQLLLQHMAHPDAATTNGYTPLHISARE 540



 Score =  119 bits (298), Expect = 3e-27
 Identities = 91/274 (33%), Positives = 133/274 (48%), Gaps = 2/274 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G+  + KLLL+  R + + R  +G T L +A     I  +  LV  GA I    ES
Sbjct: 372 AAHCGHYRVTKLLLDK-RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 430

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T +  AA  GH ++V  L   GAS +     G TAL  A++ G ++VV  LL++GA +
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
             +  +  T L +A++ G  ++++LLL   A  +    +G  PL I+++ G  +V  V+L
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIK 257
             GA    A   G T L  AA  G  DV K LL+         KNG + LH A    N K
Sbjct: 551 EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 610

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNERILRL 291
              LLLE GA P    K    P  +   +  +++
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644



 Score =  117 bits (293), Expect = 1e-26
 Identities = 92/281 (32%), Positives = 147/281 (52%), Gaps = 5/281 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+  ++  +K LL   +  VD       T L VAA+ GH    + L+ + A+ N +  +
Sbjct: 339 AAQGDHVECVKHLLQH-KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN 397

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A ++    V+  L  +GAS +  T+ G T +  A+  GH+ +V  LL++GA+ 
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
                 G TAL +AA+ G ++V+R LL +GA V+   ++   PL IAS++G +E+V+++L
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
              A  DAA  +G T L  +A +G  DV   LL+      +  K G + LH A   G++ 
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 577

Query: 258 TVALLLE--AGADPSLRNKANEL-PAELTKNERILRLLRSK 295
              LLL+  A AD + +N    L  A    N+++  LL  K
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 618



 Score =  115 bits (289), Expect = 4e-26
 Identities = 84/292 (28%), Positives = 137/292 (46%), Gaps = 39/292 (13%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A+  G   ++K+L+  G  +++ +  +G T L +AA   HID V+ L+  GA+ +   E 
Sbjct: 104 ASLAGQAEVVKVLVKEG-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATED 162

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFR------------------------------ 108
           G T L  A QQGHN  V  L       + R                              
Sbjct: 163 GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQS 222

Query: 109 -------TKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVI 161
                  T+ G T L  A+ YG++ V   LL  GA +     +G T L +A++ G  +++
Sbjct: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 282

Query: 162 RLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANK 221
           +LLL  G +++   +DG  PL  A++ GH +VV ++L RGA   A   +G + L  AA  
Sbjct: 283 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 342

Query: 222 GYNDVIKELLKF-SPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADPSLR 272
            + + +K LL+  +P   +  +  +ALH A   G+ +   LLL+  A+P+ R
Sbjct: 343 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 394



 Score =  115 bits (288), Expect = 5e-26
 Identities = 87/278 (31%), Positives = 135/278 (48%), Gaps = 6/278 (2%)

Query: 10  TPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQG 69
           TP+  AAF     G+L ++ LLL +G    D  +  G T L +AA AG ++ VR L+  G
Sbjct: 433 TPIHVAAFM----GHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487

Query: 70  ADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVE 129
           A ++ +     T L  A++ G  ++V+ L    A  +  T +G T L  +++ G + V  
Sbjct: 488 ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVAS 547

Query: 130 TLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMG 189
            LL+ GA        G T L +AA+ G LDV +LLL   A  +   ++G  PL +A+   
Sbjct: 548 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 607

Query: 190 HSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALH 248
           + +V  ++L +GA   A   +G T L  AA K    +   LL +     I+ K G + LH
Sbjct: 608 NQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 667

Query: 249 AAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNE 286
            A   G+   V LLL+ GA+  +  K+      L   E
Sbjct: 668 LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705



 Score =  115 bits (287), Expect = 6e-26
 Identities = 81/253 (32%), Positives = 123/253 (48%), Gaps = 2/253 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           +AR G + +  +LL +G          G T L VAA  G +D  + L+ + A  +   ++
Sbjct: 537 SAREGQVDVASVLLEAGAAH-SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 595

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AA   +  V   L   GAS     K+G T L  A++   MQ+  TLL +GA  
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +     G T L LA+Q G+ D++ LLL  GA ++   + G   L +A+Q     V  ++ 
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILT 715

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
             GAD+DA    G T L+ A + G   ++  LLK    +    KNG + LH A   G+  
Sbjct: 716 KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTH 775

Query: 258 TVALLLEAGADPS 270
            + +LL+ GA P+
Sbjct: 776 IINVLLQHGAKPN 788



 Score =  114 bits (285), Expect = 1e-25
 Identities = 85/245 (34%), Positives = 123/245 (50%), Gaps = 2/245 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+ G+L + KLLL   R   D    +G T L VAA+  +      L+ +GA  +   ++
Sbjct: 570 AAKYGSLDVAKLLLQR-RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AA++    +   L  +GA T   TK G T L  ASQ GH  +V  LL  GANI
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           H     G T+L LAAQ   ++V  +L   GA  +   + G  PL +A   G+ ++V  +L
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKF-SPTLGILKNGTSALHAAVLSGNIK 257
            +GA+ +A   +G T L +AA +G+  +I  LL+  +       NG +AL  A   G I 
Sbjct: 749 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYIS 808

Query: 258 TVALL 262
            V  L
Sbjct: 809 VVDTL 813



 Score =  111 bits (278), Expect = 7e-25
 Identities = 86/274 (31%), Positives = 136/274 (49%), Gaps = 6/274 (2%)

Query: 7   KKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV 66
           +++TPL      A+R G   +++LLL       D   ++G T L ++A  G +D    L+
Sbjct: 496 EEQTPL----HIASRLGKTEIVQLLLQH-MAHPDAATTNGYTPLHISAREGQVDVASVLL 550

Query: 67  LQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQ 126
             GA  +L  + G T L  AA+ G  DV + L    A+ +   K+G T L  A+ Y + +
Sbjct: 551 EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 610

Query: 127 VVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIAS 186
           V   LL+ GA+ H    +G T L +AA+   + +   LL  GA+ N   + G  PL +AS
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670

Query: 187 QMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTS 245
           Q GH+++V ++L +GA+   +   G T+L  AA +   +V   L K         K G +
Sbjct: 671 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730

Query: 246 ALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
            L  A   GN+K V  LL+ GA+ + + K    P
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 764


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  133 bits (335), Expect = 2e-31
 Identities = 92/256 (35%), Positives = 138/256 (53%), Gaps = 14/256 (5%)

Query: 53  AAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDG 112
           AA AG++D V E +  G DIN   ++G  AL  AA++GH  +V+ L G G+S +  TK G
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76

Query: 113 GTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVN 172
            TAL  AS  G  +VV+ L+K GANI+ Q  +G T L++AAQ  ++DV++ LL +GA  +
Sbjct: 77  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136

Query: 173 QPRQDGTAPLWIASQMGHSEVVRVML---LRGADR-----DAARNDGTTALLKAANKGYN 224
              +DG  PL +A Q GH++ V ++L    +G  R      AAR D T +        +N
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHN 196

Query: 225 DVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGA--DPSLRNKANEL-PAE 281
             ++  +  + T    ++G + LH A   GN+    LLL  GA  D + RN    L  A 
Sbjct: 197 ADVQSKMMVNRT---TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 253

Query: 282 LTKNERILRLLRSKEG 297
              N  +++LL  + G
Sbjct: 254 KRGNTNMVKLLLDRGG 269



 Score =  124 bits (310), Expect = 1e-28
 Identities = 83/267 (31%), Positives = 143/267 (53%), Gaps = 8/267 (2%)

Query: 19  AARRGNLALLKLLL-NSGRVDVDCR------DSHGTTLLMVAAYAGHIDCVRELVLQGAD 71
           AAR+ +     LLL N    DV  +         G T L +AA+ G+++    L+ +GA 
Sbjct: 178 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 237

Query: 72  INLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETL 131
           ++    +G T L  A+++G+ ++V+ L   G   + +T+DG T L  A++ GH QVVE L
Sbjct: 238 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297

Query: 132 LKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHS 191
           L+ GA +  +  +G + L +AAQG +++ ++ LL   A V+    D    L +A+  GH 
Sbjct: 298 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 357

Query: 192 EVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAA 250
            V +++L + A+ +A   +G T L  A  K    V++ L+K+  ++  I ++G + +H A
Sbjct: 358 RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 417

Query: 251 VLSGNIKTVALLLEAGADPSLRNKANE 277
              G++  V LLL+ GA P + N   E
Sbjct: 418 AFMGHLNIVLLLLQNGASPDVTNIRGE 444



 Score =  122 bits (306), Expect = 4e-28
 Identities = 94/309 (30%), Positives = 148/309 (47%), Gaps = 40/309 (12%)

Query: 13  ANAAFW-AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGAD 71
           +NA+F  AAR GNL  +   L  G +D++  + +G   L +AA  GH+  V+EL+ +G+ 
Sbjct: 10  SNASFLRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68

Query: 72  INLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETL 131
           ++   + G TAL  A+  G  +VV+ L   GA+   ++++G T L  A+Q  H+ VV+ L
Sbjct: 69  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128

Query: 132 LKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAK--------------------- 170
           L++GAN      DG T L +A Q G+   + +LL +  K                     
Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 188

Query: 171 ----------------VNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTA 214
                           VN+  + G  PL IA+  G+  V  ++L RGA  D    +G T 
Sbjct: 189 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 248

Query: 215 LLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIKTVALLLEAGADPSLRN 273
           L  A+ +G  +++K LL     +    ++G + LH A  SG+ + V LLLE GA    R 
Sbjct: 249 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART 308

Query: 274 KANELPAEL 282
           K    P  +
Sbjct: 309 KNGLSPLHM 317



 Score =  120 bits (300), Expect = 2e-27
 Identities = 87/270 (32%), Positives = 135/270 (50%), Gaps = 4/270 (1%)

Query: 19  AARRGNLALLKLLLN-SGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
           A++RGN  ++KLLL+  G++D   RD  G T L  AA +GH   V  L+ +GA +  + +
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTK 309

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
           +G + L  AAQ  H + V+ L    A  +  T D  TAL  A+  GH +V + LL   AN
Sbjct: 310 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 369

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVM 197
            + +  +G T L +A +   + V+ LL+  GA +    + G  P+ +A+ MGH  +V ++
Sbjct: 370 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429

Query: 198 LLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNI 256
           L  GA  D     G TAL  AA  G  +V++ LL+    +    +   + LH A   G  
Sbjct: 430 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 489

Query: 257 KTVALLLEAGADPSLRNKANELPAELTKNE 286
           + V LLL+  A P         P  ++  E
Sbjct: 490 EIVQLLLQHMAHPDAATTNGYTPLHISARE 519



 Score =  119 bits (298), Expect = 3e-27
 Identities = 91/274 (33%), Positives = 133/274 (48%), Gaps = 2/274 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G+  + KLLL+  R + + R  +G T L +A     I  +  LV  GA I    ES
Sbjct: 351 AAHCGHYRVTKLLLDK-RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 409

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T +  AA  GH ++V  L   GAS +     G TAL  A++ G ++VV  LL++GA +
Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 469

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
             +  +  T L +A++ G  ++++LLL   A  +    +G  PL I+++ G  +V  V+L
Sbjct: 470 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 529

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIK 257
             GA    A   G T L  AA  G  DV K LL+         KNG + LH A    N K
Sbjct: 530 EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 589

Query: 258 TVALLLEAGADPSLRNKANELPAELTKNERILRL 291
              LLLE GA P    K    P  +   +  +++
Sbjct: 590 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 623



 Score =  117 bits (293), Expect = 1e-26
 Identities = 92/281 (32%), Positives = 147/281 (52%), Gaps = 5/281 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+  ++  +K LL   +  VD       T L VAA+ GH    + L+ + A+ N +  +
Sbjct: 318 AAQGDHVECVKHLLQH-KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN 376

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  A ++    V+  L  +GAS +  T+ G T +  A+  GH+ +V  LL++GA+ 
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
                 G TAL +AA+ G ++V+R LL +GA V+   ++   PL IAS++G +E+V+++L
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
              A  DAA  +G T L  +A +G  DV   LL+      +  K G + LH A   G++ 
Sbjct: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 556

Query: 258 TVALLLE--AGADPSLRNKANEL-PAELTKNERILRLLRSK 295
              LLL+  A AD + +N    L  A    N+++  LL  K
Sbjct: 557 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 597



 Score =  115 bits (289), Expect = 4e-26
 Identities = 84/292 (28%), Positives = 137/292 (46%), Gaps = 39/292 (13%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A+  G   ++K+L+  G  +++ +  +G T L +AA   HID V+ L+  GA+ +   E 
Sbjct: 83  ASLAGQAEVVKVLVKEG-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATED 141

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFR------------------------------ 108
           G T L  A QQGHN  V  L       + R                              
Sbjct: 142 GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQS 201

Query: 109 -------TKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVI 161
                  T+ G T L  A+ YG++ V   LL  GA +     +G T L +A++ G  +++
Sbjct: 202 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 261

Query: 162 RLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANK 221
           +LLL  G +++   +DG  PL  A++ GH +VV ++L RGA   A   +G + L  AA  
Sbjct: 262 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 321

Query: 222 GYNDVIKELLKF-SPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADPSLR 272
            + + +K LL+  +P   +  +  +ALH A   G+ +   LLL+  A+P+ R
Sbjct: 322 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 373



 Score =  115 bits (288), Expect = 5e-26
 Identities = 87/278 (31%), Positives = 135/278 (48%), Gaps = 6/278 (2%)

Query: 10  TPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQG 69
           TP+  AAF     G+L ++ LLL +G    D  +  G T L +AA AG ++ VR L+  G
Sbjct: 412 TPIHVAAFM----GHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 466

Query: 70  ADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVE 129
           A ++ +     T L  A++ G  ++V+ L    A  +  T +G T L  +++ G + V  
Sbjct: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVAS 526

Query: 130 TLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMG 189
            LL+ GA        G T L +AA+ G LDV +LLL   A  +   ++G  PL +A+   
Sbjct: 527 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 586

Query: 190 HSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALH 248
           + +V  ++L +GA   A   +G T L  AA K    +   LL +     I+ K G + LH
Sbjct: 587 NQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 646

Query: 249 AAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNE 286
            A   G+   V LLL+ GA+  +  K+      L   E
Sbjct: 647 LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 684



 Score =  115 bits (287), Expect = 6e-26
 Identities = 81/253 (32%), Positives = 123/253 (48%), Gaps = 2/253 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           +AR G + +  +LL +G          G T L VAA  G +D  + L+ + A  +   ++
Sbjct: 516 SAREGQVDVASVLLEAGAAH-SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 574

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AA   +  V   L   GAS     K+G T L  A++   MQ+  TLL +GA  
Sbjct: 575 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 634

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           +     G T L LA+Q G+ D++ LLL  GA ++   + G   L +A+Q     V  ++ 
Sbjct: 635 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILT 694

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIK 257
             GAD+DA    G T L+ A + G   ++  LLK    +    KNG + LH A   G+  
Sbjct: 695 KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTH 754

Query: 258 TVALLLEAGADPS 270
            + +LL+ GA P+
Sbjct: 755 IINVLLQHGAKPN 767



 Score =  114 bits (285), Expect = 1e-25
 Identities = 85/245 (34%), Positives = 123/245 (50%), Gaps = 2/245 (0%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA+ G+L + KLLL   R   D    +G T L VAA+  +      L+ +GA  +   ++
Sbjct: 549 AAKYGSLDVAKLLLQR-RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 607

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
           G T L  AA++    +   L  +GA T   TK G T L  ASQ GH  +V  LL  GANI
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198
           H     G T+L LAAQ   ++V  +L   GA  +   + G  PL +A   G+ ++V  +L
Sbjct: 668 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 727

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKF-SPTLGILKNGTSALHAAVLSGNIK 257
            +GA+ +A   +G T L +AA +G+  +I  LL+  +       NG +AL  A   G I 
Sbjct: 728 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYIS 787

Query: 258 TVALL 262
            V  L
Sbjct: 788 VVDTL 792



 Score =  111 bits (278), Expect = 7e-25
 Identities = 86/274 (31%), Positives = 136/274 (49%), Gaps = 6/274 (2%)

Query: 7   KKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV 66
           +++TPL      A+R G   +++LLL       D   ++G T L ++A  G +D    L+
Sbjct: 475 EEQTPL----HIASRLGKTEIVQLLLQH-MAHPDAATTNGYTPLHISAREGQVDVASVLL 529

Query: 67  LQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQ 126
             GA  +L  + G T L  AA+ G  DV + L    A+ +   K+G T L  A+ Y + +
Sbjct: 530 EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 589

Query: 127 VVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIAS 186
           V   LL+ GA+ H    +G T L +AA+   + +   LL  GA+ N   + G  PL +AS
Sbjct: 590 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 649

Query: 187 QMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTS 245
           Q GH+++V ++L +GA+   +   G T+L  AA +   +V   L K         K G +
Sbjct: 650 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 709

Query: 246 ALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
            L  A   GN+K V  LL+ GA+ + + K    P
Sbjct: 710 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 743



 Score =  101 bits (252), Expect = 7e-22
 Identities = 67/202 (33%), Positives = 111/202 (54%), Gaps = 5/202 (2%)

Query: 74  LQRESGTTALFFAAQQGHND-VVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLL 132
           LQ+     +   AA+ G+ D VV +L G G       ++G  AL  A++ GH+ +V+ LL
Sbjct: 5   LQKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELL 63

Query: 133 KHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSE 192
             G+++      G TAL +A+  G  +V+++L+  GA +N   Q+G  PL++A+Q  H +
Sbjct: 64  GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHID 123

Query: 193 VVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVL 252
           VV+ +L  GA++  A  DG T L  A  +G+N  +  LL+ + T G  K    ALH A  
Sbjct: 124 VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-NDTKG--KVRLPALHIAAR 180

Query: 253 SGNIKTVALLLEAGADPSLRNK 274
             + K+ ALLL+   +  +++K
Sbjct: 181 KDDTKSAALLLQNDHNADVQSK 202



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 58/192 (30%), Positives = 100/192 (52%), Gaps = 1/192 (0%)

Query: 104 STEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRL 163
           +T  +  D   + L A++ G++  V   LK G +I+    +G  AL LAA+ G++ +++ 
Sbjct: 2   TTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE 61

Query: 164 LLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGY 223
           LL  G+ V+   + G   L IAS  G +EVV+V++  GA+ +A   +G T L  AA + +
Sbjct: 62  LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 121

Query: 224 NDVIKELLKFSPTLG-ILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
            DV+K LL+         ++G + L  A+  G+ + VA+LLE      +R  A  + A  
Sbjct: 122 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 181

Query: 283 TKNERILRLLRS 294
              +    LL++
Sbjct: 182 DDTKSAALLLQN 193


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  127 bits (319), Expect = 1e-29
 Identities = 90/260 (34%), Positives = 138/260 (53%), Gaps = 12/260 (4%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A+  G L ++KLLL     DV+ + + G T L  A   G +D V+ L+ +GA+I    E+
Sbjct: 279 ASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 337

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGA-----STEFRTKDGGTALLAASQYGHMQVVETLLK 133
           G T L  AA  GH +V R L   GA     S EF+     +AL  A   GH+ +V  LL+
Sbjct: 338 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE----SALTLACYKGHLDMVRFLLE 393

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            GA+   +  +  TAL  A   G+++V RLLL SGA+VN P     +PL +A+  GH E+
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453

Query: 194 VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGT--SALHAAV 251
             +++ RGA+ +   ++G T L++AA +G+ +++  LL     +      T  +AL  A 
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513

Query: 252 LSGNIKTVALLLEAGADPSL 271
             G  +    L++AGAD  L
Sbjct: 514 CGGFSEVADFLIKAGADIEL 533



 Score =  126 bits (317), Expect = 2e-29
 Identities = 87/256 (33%), Positives = 141/256 (55%), Gaps = 5/256 (1%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A  +A   G + ++K+LLN G  +++  + +G T LM AA AGH++  R L+  GA IN 
Sbjct: 308 ALTYACAGGFVDIVKVLLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINT 366

Query: 75  Q-RESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
              E   +AL  A  +GH D+VRFL   GA  E +T +  TAL+ A   GH++V   LL 
Sbjct: 367 HSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            GA ++       + L LAA GG++++  LL+  GA + +   +G  PL  A++ GH E+
Sbjct: 427 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 486

Query: 194 VRVMLLRGADRDAARND-GTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVL 252
           V ++L +GA+ +A   +   TAL  A   G+++V   L+K    + +    ++ L  A  
Sbjct: 487 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL--GCSTPLMEASQ 544

Query: 253 SGNIKTVALLLEAGAD 268
            G+++ V  LL +GA+
Sbjct: 545 EGHLELVKYLLASGAN 560



 Score =  120 bits (301), Expect = 1e-27
 Identities = 81/256 (31%), Positives = 135/256 (52%), Gaps = 17/256 (6%)

Query: 33  NSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHN 92
           N+G+VD        T  L  A   G ++ VR+L+ +G  +N   E G + L  A   G+ 
Sbjct: 200 NAGQVD--------TRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYY 251

Query: 93  DVVRFLFGFGASTEFRTKDGG-TALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFL 151
           ++ + L    A+ E R   G  T L+AAS  G++ +V+ LL H A+++ Q   G TAL  
Sbjct: 252 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 311

Query: 152 AAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARND- 210
           A  GG++D++++LL  GA +    ++G  PL  A+  GH EV RV+L  GA  +   N+ 
Sbjct: 312 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371

Query: 211 GTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAV----LSGNIKTVALLLEAG 266
             +AL  A  KG+ D+++ LL+        ++ T  +H A+    + G+++   LLL++G
Sbjct: 372 KESALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHTALMEACMDGHVEVARLLLDSG 428

Query: 267 ADPSLRNKANELPAEL 282
           A  ++   + E P  L
Sbjct: 429 AQVNMPADSFESPLTL 444



 Score =  110 bits (275), Expect = 2e-24
 Identities = 79/226 (34%), Positives = 119/226 (52%), Gaps = 9/226 (3%)

Query: 8   KETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVL 67
           KE+ L  A +    +G+L +++ LL +G  D + +     T LM A   GH++  R L+ 
Sbjct: 372 KESALTLACY----KGHLDMVRFLLEAG-ADQEHKTDEMHTALMEACMDGHVEVARLLLD 426

Query: 68  QGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQV 127
            GA +N+  +S  + L  AA  GH ++   L   GA+ E    +G T L+ A++ GH ++
Sbjct: 427 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 486

Query: 128 VETLLKHGANIHDQLYDGA-TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIAS 186
           V  LL  GANI+ Q  +   TAL LA  GG+ +V   L+ +GA +       + PL  AS
Sbjct: 487 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEAS 543

Query: 187 QMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLK 232
           Q GH E+V+ +L  GA+  A    G TAL  A   G+ DV   LL+
Sbjct: 544 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 61/156 (39%), Positives = 87/156 (55%), Gaps = 5/156 (3%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQ-RE 77
           AA  G++ L  LL+  G  +++  +  G T LM AA  GH + V  L+ QGA+IN Q  E
Sbjct: 445 AACGGHVELAALLIERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
           +  TAL  A   G ++V  FL   GA  E       T L+ ASQ GH+++V+ LL  GAN
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN 560

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQ 173
           +H     G TAL  A + G+ DV  +LL +GA +++
Sbjct: 561 VHATTATGDTALTYACENGHTDVADVLLQAGADLDK 596



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 42/145 (28%), Positives = 69/145 (47%), Gaps = 2/145 (1%)

Query: 137 NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRV 196
           N H+       +L  A   G ++ +R LL  G  VN+  ++G + L +A   G+ E+ +V
Sbjct: 197 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256

Query: 197 MLLRGADRDAARNDG-TTALLKAANKGYNDVIKELLKFSPTLGILK-NGTSALHAAVLSG 254
           +L   A+ +   N G  T L+ A++ GY D++K LL     +      G +AL  A   G
Sbjct: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316

Query: 255 NIKTVALLLEAGADPSLRNKANELP 279
            +  V +LL  GA+    N+    P
Sbjct: 317 FVDIVKVLLNEGANIEDHNENGHTP 341



 Score = 36.6 bits (83), Expect = 0.028
 Identities = 23/62 (37%), Positives = 33/62 (53%), Gaps = 1/62 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A++ G+L L+K LL SG  +V    + G T L  A   GH D    L+  GAD++ Q + 
Sbjct: 542 ASQEGHLELVKYLLASG-ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM 600

Query: 79  GT 80
            T
Sbjct: 601 KT 602


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  127 bits (319), Expect = 1e-29
 Identities = 90/260 (34%), Positives = 138/260 (53%), Gaps = 12/260 (4%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A+  G L ++KLLL     DV+ + + G T L  A   G +D V+ L+ +GA+I    E+
Sbjct: 268 ASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 326

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGA-----STEFRTKDGGTALLAASQYGHMQVVETLLK 133
           G T L  AA  GH +V R L   GA     S EF+     +AL  A   GH+ +V  LL+
Sbjct: 327 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE----SALTLACYKGHLDMVRFLLE 382

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            GA+   +  +  TAL  A   G+++V RLLL SGA+VN P     +PL +A+  GH E+
Sbjct: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 442

Query: 194 VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGT--SALHAAV 251
             +++ RGA+ +   ++G T L++AA +G+ +++  LL     +      T  +AL  A 
Sbjct: 443 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 502

Query: 252 LSGNIKTVALLLEAGADPSL 271
             G  +    L++AGAD  L
Sbjct: 503 CGGFSEVADFLIKAGADIEL 522



 Score =  126 bits (317), Expect = 2e-29
 Identities = 87/256 (33%), Positives = 141/256 (55%), Gaps = 5/256 (1%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A  +A   G + ++K+LLN G  +++  + +G T LM AA AGH++  R L+  GA IN 
Sbjct: 297 ALTYACAGGFVDIVKVLLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINT 355

Query: 75  Q-RESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
              E   +AL  A  +GH D+VRFL   GA  E +T +  TAL+ A   GH++V   LL 
Sbjct: 356 HSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            GA ++       + L LAA GG++++  LL+  GA + +   +G  PL  A++ GH E+
Sbjct: 416 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 475

Query: 194 VRVMLLRGADRDAARND-GTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVL 252
           V ++L +GA+ +A   +   TAL  A   G+++V   L+K    + +    ++ L  A  
Sbjct: 476 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL--GCSTPLMEASQ 533

Query: 253 SGNIKTVALLLEAGAD 268
            G+++ V  LL +GA+
Sbjct: 534 EGHLELVKYLLASGAN 549



 Score =  120 bits (301), Expect = 1e-27
 Identities = 81/256 (31%), Positives = 135/256 (52%), Gaps = 17/256 (6%)

Query: 33  NSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHN 92
           N+G+VD        T  L  A   G ++ VR+L+ +G  +N   E G + L  A   G+ 
Sbjct: 189 NAGQVD--------TRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYY 240

Query: 93  DVVRFLFGFGASTEFRTKDGG-TALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFL 151
           ++ + L    A+ E R   G  T L+AAS  G++ +V+ LL H A+++ Q   G TAL  
Sbjct: 241 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 300

Query: 152 AAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARND- 210
           A  GG++D++++LL  GA +    ++G  PL  A+  GH EV RV+L  GA  +   N+ 
Sbjct: 301 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 360

Query: 211 GTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAV----LSGNIKTVALLLEAG 266
             +AL  A  KG+ D+++ LL+        ++ T  +H A+    + G+++   LLL++G
Sbjct: 361 KESALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHTALMEACMDGHVEVARLLLDSG 417

Query: 267 ADPSLRNKANELPAEL 282
           A  ++   + E P  L
Sbjct: 418 AQVNMPADSFESPLTL 433



 Score =  110 bits (275), Expect = 2e-24
 Identities = 79/226 (34%), Positives = 119/226 (52%), Gaps = 9/226 (3%)

Query: 8   KETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVL 67
           KE+ L  A +    +G+L +++ LL +G  D + +     T LM A   GH++  R L+ 
Sbjct: 361 KESALTLACY----KGHLDMVRFLLEAG-ADQEHKTDEMHTALMEACMDGHVEVARLLLD 415

Query: 68  QGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQV 127
            GA +N+  +S  + L  AA  GH ++   L   GA+ E    +G T L+ A++ GH ++
Sbjct: 416 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 475

Query: 128 VETLLKHGANIHDQLYDGA-TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIAS 186
           V  LL  GANI+ Q  +   TAL LA  GG+ +V   L+ +GA +       + PL  AS
Sbjct: 476 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEAS 532

Query: 187 QMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLK 232
           Q GH E+V+ +L  GA+  A    G TAL  A   G+ DV   LL+
Sbjct: 533 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 578



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 61/156 (39%), Positives = 87/156 (55%), Gaps = 5/156 (3%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQ-RE 77
           AA  G++ L  LL+  G  +++  +  G T LM AA  GH + V  L+ QGA+IN Q  E
Sbjct: 434 AACGGHVELAALLIERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
           +  TAL  A   G ++V  FL   GA  E       T L+ ASQ GH+++V+ LL  GAN
Sbjct: 493 TQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN 549

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQ 173
           +H     G TAL  A + G+ DV  +LL +GA +++
Sbjct: 550 VHATTATGDTALTYACENGHTDVADVLLQAGADLDK 585



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 54/206 (26%), Positives = 86/206 (41%), Gaps = 23/206 (11%)

Query: 97  FLFGFGASTEFRTKDGGT-----ALLAASQYGHMQVVETLLKH----------------G 135
           FL       + RT D  T     ALL A+ +   +V+  L                    
Sbjct: 125 FLSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKA 184

Query: 136 ANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVR 195
            N H+       +L  A   G ++ +R LL  G  VN+  ++G + L +A   G+ E+ +
Sbjct: 185 ENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQ 244

Query: 196 VMLLRGADRDAARNDG-TTALLKAANKGYNDVIKELLKFSPTLGILK-NGTSALHAAVLS 253
           V+L   A+ +   N G  T L+ A++ GY D++K LL     +      G +AL  A   
Sbjct: 245 VLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAG 304

Query: 254 GNIKTVALLLEAGADPSLRNKANELP 279
           G +  V +LL  GA+    N+    P
Sbjct: 305 GFVDIVKVLLNEGANIEDHNENGHTP 330



 Score = 36.6 bits (83), Expect = 0.028
 Identities = 23/62 (37%), Positives = 33/62 (53%), Gaps = 1/62 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A++ G+L L+K LL SG  +V    + G T L  A   GH D    L+  GAD++ Q + 
Sbjct: 531 ASQEGHLELVKYLLASG-ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM 589

Query: 79  GT 80
            T
Sbjct: 590 KT 591


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  127 bits (319), Expect = 1e-29
 Identities = 90/260 (34%), Positives = 138/260 (53%), Gaps = 12/260 (4%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A+  G L ++KLLL     DV+ + + G T L  A   G +D V+ L+ +GA+I    E+
Sbjct: 279 ASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 337

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGA-----STEFRTKDGGTALLAASQYGHMQVVETLLK 133
           G T L  AA  GH +V R L   GA     S EF+     +AL  A   GH+ +V  LL+
Sbjct: 338 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE----SALTLACYKGHLDMVRFLLE 393

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            GA+   +  +  TAL  A   G+++V RLLL SGA+VN P     +PL +A+  GH E+
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453

Query: 194 VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGT--SALHAAV 251
             +++ RGA+ +   ++G T L++AA +G+ +++  LL     +      T  +AL  A 
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513

Query: 252 LSGNIKTVALLLEAGADPSL 271
             G  +    L++AGAD  L
Sbjct: 514 CGGFSEVADFLIKAGADIEL 533



 Score =  126 bits (317), Expect = 2e-29
 Identities = 87/256 (33%), Positives = 141/256 (55%), Gaps = 5/256 (1%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A  +A   G + ++K+LLN G  +++  + +G T LM AA AGH++  R L+  GA IN 
Sbjct: 308 ALTYACAGGFVDIVKVLLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINT 366

Query: 75  Q-RESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
              E   +AL  A  +GH D+VRFL   GA  E +T +  TAL+ A   GH++V   LL 
Sbjct: 367 HSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            GA ++       + L LAA GG++++  LL+  GA + +   +G  PL  A++ GH E+
Sbjct: 427 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 486

Query: 194 VRVMLLRGADRDAARND-GTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVL 252
           V ++L +GA+ +A   +   TAL  A   G+++V   L+K    + +    ++ L  A  
Sbjct: 487 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL--GCSTPLMEASQ 544

Query: 253 SGNIKTVALLLEAGAD 268
            G+++ V  LL +GA+
Sbjct: 545 EGHLELVKYLLASGAN 560



 Score =  124 bits (310), Expect = 1e-28
 Identities = 82/219 (37%), Positives = 124/219 (56%), Gaps = 6/219 (2%)

Query: 19   AARRGNLALLKLLLNSGRVDVDCRDSH--GTTLLMVAAYAGHIDCVRELVLQGADINLQR 76
            AA  G + ++K+LLN+G  +++ R     G + LM+AA  GH+  V+ L+  G+DIN Q 
Sbjct: 1162 AASGGYVNIIKILLNAG-AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQI 1220

Query: 77   ESG-TTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHG 135
            E+   TAL  A  QG  +VV  L    A+ E R K G T L+ A+  G+ +V   LL  G
Sbjct: 1221 ETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG 1280

Query: 136  ANIHDQLYDGA--TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            A+++      +  TAL +AA  G+     LL+  GA ++   + G  PLW+AS  GH +V
Sbjct: 1281 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV 1340

Query: 194  VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLK 232
            V++++  GAD DAA N   T L+ A  KG+  V++ L+K
Sbjct: 1341 VQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  120 bits (301), Expect = 1e-27
 Identities = 81/256 (31%), Positives = 135/256 (52%), Gaps = 17/256 (6%)

Query: 33  NSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHN 92
           N+G+VD        T  L  A   G ++ VR+L+ +G  +N   E G + L  A   G+ 
Sbjct: 200 NAGQVD--------TRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYY 251

Query: 93  DVVRFLFGFGASTEFRTKDGG-TALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFL 151
           ++ + L    A+ E R   G  T L+AAS  G++ +V+ LL H A+++ Q   G TAL  
Sbjct: 252 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 311

Query: 152 AAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARND- 210
           A  GG++D++++LL  GA +    ++G  PL  A+  GH EV RV+L  GA  +   N+ 
Sbjct: 312 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371

Query: 211 GTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAV----LSGNIKTVALLLEAG 266
             +AL  A  KG+ D+++ LL+        ++ T  +H A+    + G+++   LLL++G
Sbjct: 372 KESALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHTALMEACMDGHVEVARLLLDSG 428

Query: 267 ADPSLRNKANELPAEL 282
           A  ++   + E P  L
Sbjct: 429 AQVNMPADSFESPLTL 444



 Score =  118 bits (296), Expect = 6e-27
 Identities = 90/300 (30%), Positives = 142/300 (47%), Gaps = 38/300 (12%)

Query: 8   KETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVL 67
           KE+ L  A +    +G+L +++ LL +G  D + +     T LM A   GH++  R L+ 
Sbjct: 372 KESALTLACY----KGHLDMVRFLLEAG-ADQEHKTDEMHTALMEACMDGHVEVARLLLD 426

Query: 68  QGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQV 127
            GA +N+  +S  + L  AA  GH ++   L   GA+ E    +G T L+ A++ GH ++
Sbjct: 427 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 486

Query: 128 VETLLKHGANIHDQLYDG-------------------------------ATALFLAAQGG 156
           V  LL  GANI+ Q  +                                +T L  A+Q G
Sbjct: 487 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEG 546

Query: 157 YLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALL 216
           +L++++ LLASGA V+     G   L  A + GH++V  V+L  GAD +     G T L+
Sbjct: 547 HLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLM 606

Query: 217 KAANKGYNDVIKELLKFSPTLG--ILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNK 274
           KAA  G+   ++ L+     +      N  + +  A   G++  V LLL  GADP+ R K
Sbjct: 607 KAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLK 666



 Score =  117 bits (292), Expect = 2e-26
 Identities = 92/251 (36%), Positives = 133/251 (52%), Gaps = 11/251 (4%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQ-RE 77
           AA  G++ L  LL+  G  +++  +  G T LM AA  GH + V  L+ QGA+IN Q  E
Sbjct: 445 AACGGHVELAALLIERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
           +  TAL  A   G ++V  FL   GA  E       T L+ ASQ GH+++V+ LL  GAN
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN 560

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVM 197
           +H     G TAL  A + G+ DV  +LL +GA +    + G  PL  A++ GH   V+ +
Sbjct: 561 VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFL 620

Query: 198 LLRGA--DRDAARNDGTTALLKAANKGYNDVIKELLKF--SPTLGILKNGTSALHAAVLS 253
           + +GA  +R  A ND T   L  A  G+  V++ LL     PT   LK+G++ L  A   
Sbjct: 621 ISKGANVNRATANNDHTVVSLACAG-GHLAVVELLLAHGADPT-HRLKDGSTMLIEAAKG 678

Query: 254 GNIKTVALLLE 264
           G+   V+ LL+
Sbjct: 679 GHTNVVSYLLD 689



 Score =  107 bits (266), Expect = 2e-23
 Identities = 88/259 (33%), Positives = 128/259 (49%), Gaps = 16/259 (6%)

Query: 37   VDVDCR-DSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVV 95
            VD+D   +S+  T L +A   GH + V  L+ + A I  + + G T L  AA  GH  VV
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104

Query: 96   RFLFGFGASTEF---RTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLA 152
              L   G   E    RTKD  T L  A   G  +VV+ LL  GAN   +     T L LA
Sbjct: 1105 EILLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162

Query: 153  AQGGYLDVIRLLLASGAKVNQPRQD--GTAPLWIASQMGHSEVVRVMLLRGADRDA-ARN 209
            A GGY+++I++LL +GA++N       G +PL +A+  GH   V+++L  G+D +A    
Sbjct: 1163 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIET 1222

Query: 210  DGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAAVLSGNIKTVALLLEAGAD 268
            +  TAL  A  +G  +V+  LL     +    K G + L  A   G  +   +LL+ GAD
Sbjct: 1223 NRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1282

Query: 269  ------PSLRNKANELPAE 281
                  PS R+ A  + A+
Sbjct: 1283 VNAPPVPSSRDTALTIAAD 1301



 Score =  100 bits (250), Expect = 1e-21
 Identities = 84/257 (32%), Positives = 134/257 (52%), Gaps = 8/257 (3%)

Query: 19   AARRGNLALLKLLLNSGRVDVDCRDSHGT-TLLMVAAYAGHIDCVRELVLQGADINLQRE 77
            AA  G++ ++++LL+ G  D++ +      T L +A   G  + V  L+ +GA+   +  
Sbjct: 1095 AATAGHVGVVEILLDKGG-DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 1153

Query: 78   SGTTALFFAAQQGHNDVVRFLFGFGASTEFRT--KDGGTALLAASQYGHMQVVETLLKHG 135
            S  T L  AA  G+ ++++ L   GA    RT  K G + L+ A+  GH+  V+ LL  G
Sbjct: 1154 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213

Query: 136  ANIHDQLYDGA-TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVV 194
            ++I+ Q+     TAL LA   G  +V+ LLL   A V    + G  PL  A+  G++EV 
Sbjct: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273

Query: 195  RVMLLRGADRDA--ARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAV 251
            RV+L +GAD +A    +   TAL  AA+KG+    + L+     + +  K G + L  A 
Sbjct: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333

Query: 252  LSGNIKTVALLLEAGAD 268
              G+   V LL++AGAD
Sbjct: 1334 NGGHFDVVQLLVQAGAD 1350



 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 44/125 (35%), Positives = 64/125 (51%), Gaps = 2/125 (1%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A  +A   G+  +  +LL +G  D++     G T LM AA AGH+  V+ L+ +GA++N 
Sbjct: 571 ALTYACENGHTDVADVLLQAG-ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629

Query: 75  QRESGT-TALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
              +   T +  A   GH  VV  L   GA    R KDG T L+ A++ GH  VV  LL 
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689

Query: 134 HGANI 138
           +  N+
Sbjct: 690 YPNNV 694



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 42/145 (28%), Positives = 69/145 (47%), Gaps = 2/145 (1%)

Query: 137 NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRV 196
           N H+       +L  A   G ++ +R LL  G  VN+  ++G + L +A   G+ E+ +V
Sbjct: 197 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256

Query: 197 MLLRGADRDAARNDG-TTALLKAANKGYNDVIKELLKFSPTLGILK-NGTSALHAAVLSG 254
           +L   A+ +   N G  T L+ A++ GY D++K LL     +      G +AL  A   G
Sbjct: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316

Query: 255 NIKTVALLLEAGADPSLRNKANELP 279
            +  V +LL  GA+    N+    P
Sbjct: 317 FVDIVKVLLNEGANIEDHNENGHTP 341



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 39/147 (26%), Positives = 63/147 (42%), Gaps = 31/147 (21%)

Query: 147  TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDA 206
            TAL LA  GG+ +++ +L+A  AK+    + G  PL +A+  GH  VV ++L +G D +A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 207  ARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAG 266
                                  E  K +P           L  A   G  + V LLL  G
Sbjct: 1117 Q--------------------SERTKDTP-----------LSLACSGGRQEVVDLLLARG 1145

Query: 267  ADPSLRNKANELPAELTKNERILRLLR 293
            A+   RN ++  P  L  +   + +++
Sbjct: 1146 ANKEHRNVSDYTPLSLAASGGYVNIIK 1172



 Score = 32.3 bits (72), Expect = 0.53
 Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 2/54 (3%)

Query: 14   NAAFW-AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV 66
            N   W A+  G+  +++LL+ +G  DVD  D+   T LM A   GH+  V+ LV
Sbjct: 1326 NTPLWLASNGGHFDVVQLLVQAG-ADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  127 bits (319), Expect = 1e-29
 Identities = 90/260 (34%), Positives = 138/260 (53%), Gaps = 12/260 (4%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           A+  G L ++KLLL     DV+ + + G T L  A   G +D V+ L+ +GA+I    E+
Sbjct: 279 ASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 337

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGA-----STEFRTKDGGTALLAASQYGHMQVVETLLK 133
           G T L  AA  GH +V R L   GA     S EF+     +AL  A   GH+ +V  LL+
Sbjct: 338 GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE----SALTLACYKGHLDMVRFLLE 393

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            GA+   +  +  TAL  A   G+++V RLLL SGA+VN P     +PL +A+  GH E+
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453

Query: 194 VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGT--SALHAAV 251
             +++ RGA+ +   ++G T L++AA +G+ +++  LL     +      T  +AL  A 
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513

Query: 252 LSGNIKTVALLLEAGADPSL 271
             G  +    L++AGAD  L
Sbjct: 514 CGGFSEVADFLIKAGADIEL 533



 Score =  126 bits (317), Expect = 2e-29
 Identities = 87/256 (33%), Positives = 141/256 (55%), Gaps = 5/256 (1%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A  +A   G + ++K+LLN G  +++  + +G T LM AA AGH++  R L+  GA IN 
Sbjct: 308 ALTYACAGGFVDIVKVLLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINT 366

Query: 75  Q-RESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
              E   +AL  A  +GH D+VRFL   GA  E +T +  TAL+ A   GH++V   LL 
Sbjct: 367 HSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            GA ++       + L LAA GG++++  LL+  GA + +   +G  PL  A++ GH E+
Sbjct: 427 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 486

Query: 194 VRVMLLRGADRDAARND-GTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVL 252
           V ++L +GA+ +A   +   TAL  A   G+++V   L+K    + +    ++ L  A  
Sbjct: 487 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL--GCSTPLMEASQ 544

Query: 253 SGNIKTVALLLEAGAD 268
            G+++ V  LL +GA+
Sbjct: 545 EGHLELVKYLLASGAN 560



 Score =  124 bits (310), Expect = 1e-28
 Identities = 82/219 (37%), Positives = 124/219 (56%), Gaps = 6/219 (2%)

Query: 19   AARRGNLALLKLLLNSGRVDVDCRDSH--GTTLLMVAAYAGHIDCVRELVLQGADINLQR 76
            AA  G + ++K+LLN+G  +++ R     G + LM+AA  GH+  V+ L+  G+DIN Q 
Sbjct: 1162 AASGGYVNIIKILLNAG-AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQI 1220

Query: 77   ESG-TTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHG 135
            E+   TAL  A  QG  +VV  L    A+ E R K G T L+ A+  G+ +V   LL  G
Sbjct: 1221 ETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG 1280

Query: 136  ANIHDQLYDGA--TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            A+++      +  TAL +AA  G+     LL+  GA ++   + G  PLW+AS  GH +V
Sbjct: 1281 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV 1340

Query: 194  VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLK 232
            V++++  GAD DAA N   T L+ A  KG+  V++ L+K
Sbjct: 1341 VQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  120 bits (301), Expect = 1e-27
 Identities = 81/256 (31%), Positives = 135/256 (52%), Gaps = 17/256 (6%)

Query: 33  NSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHN 92
           N+G+VD        T  L  A   G ++ VR+L+ +G  +N   E G + L  A   G+ 
Sbjct: 200 NAGQVD--------TRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYY 251

Query: 93  DVVRFLFGFGASTEFRTKDGG-TALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFL 151
           ++ + L    A+ E R   G  T L+AAS  G++ +V+ LL H A+++ Q   G TAL  
Sbjct: 252 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 311

Query: 152 AAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARND- 210
           A  GG++D++++LL  GA +    ++G  PL  A+  GH EV RV+L  GA  +   N+ 
Sbjct: 312 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371

Query: 211 GTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAV----LSGNIKTVALLLEAG 266
             +AL  A  KG+ D+++ LL+        ++ T  +H A+    + G+++   LLL++G
Sbjct: 372 KESALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHTALMEACMDGHVEVARLLLDSG 428

Query: 267 ADPSLRNKANELPAEL 282
           A  ++   + E P  L
Sbjct: 429 AQVNMPADSFESPLTL 444



 Score =  118 bits (296), Expect = 6e-27
 Identities = 90/300 (30%), Positives = 142/300 (47%), Gaps = 38/300 (12%)

Query: 8   KETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVL 67
           KE+ L  A +    +G+L +++ LL +G  D + +     T LM A   GH++  R L+ 
Sbjct: 372 KESALTLACY----KGHLDMVRFLLEAG-ADQEHKTDEMHTALMEACMDGHVEVARLLLD 426

Query: 68  QGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQV 127
            GA +N+  +S  + L  AA  GH ++   L   GA+ E    +G T L+ A++ GH ++
Sbjct: 427 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 486

Query: 128 VETLLKHGANIHDQLYDG-------------------------------ATALFLAAQGG 156
           V  LL  GANI+ Q  +                                +T L  A+Q G
Sbjct: 487 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEG 546

Query: 157 YLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALL 216
           +L++++ LLASGA V+     G   L  A + GH++V  V+L  GAD +     G T L+
Sbjct: 547 HLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLM 606

Query: 217 KAANKGYNDVIKELLKFSPTLG--ILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNK 274
           KAA  G+   ++ L+     +      N  + +  A   G++  V LLL  GADP+ R K
Sbjct: 607 KAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLK 666



 Score =  117 bits (292), Expect = 2e-26
 Identities = 92/251 (36%), Positives = 133/251 (52%), Gaps = 11/251 (4%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQ-RE 77
           AA  G++ L  LL+  G  +++  +  G T LM AA  GH + V  L+ QGA+IN Q  E
Sbjct: 445 AACGGHVELAALLIERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
           +  TAL  A   G ++V  FL   GA  E       T L+ ASQ GH+++V+ LL  GAN
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN 560

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVM 197
           +H     G TAL  A + G+ DV  +LL +GA +    + G  PL  A++ GH   V+ +
Sbjct: 561 VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFL 620

Query: 198 LLRGA--DRDAARNDGTTALLKAANKGYNDVIKELLKF--SPTLGILKNGTSALHAAVLS 253
           + +GA  +R  A ND T   L  A  G+  V++ LL     PT   LK+G++ L  A   
Sbjct: 621 ISKGANVNRATANNDHTVVSLACAG-GHLAVVELLLAHGADPT-HRLKDGSTMLIEAAKG 678

Query: 254 GNIKTVALLLE 264
           G+   V+ LL+
Sbjct: 679 GHTNVVSYLLD 689



 Score =  107 bits (266), Expect = 2e-23
 Identities = 88/259 (33%), Positives = 128/259 (49%), Gaps = 16/259 (6%)

Query: 37   VDVDCR-DSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVV 95
            VD+D   +S+  T L +A   GH + V  L+ + A I  + + G T L  AA  GH  VV
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104

Query: 96   RFLFGFGASTEF---RTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLA 152
              L   G   E    RTKD  T L  A   G  +VV+ LL  GAN   +     T L LA
Sbjct: 1105 EILLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162

Query: 153  AQGGYLDVIRLLLASGAKVNQPRQD--GTAPLWIASQMGHSEVVRVMLLRGADRDA-ARN 209
            A GGY+++I++LL +GA++N       G +PL +A+  GH   V+++L  G+D +A    
Sbjct: 1163 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIET 1222

Query: 210  DGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAAVLSGNIKTVALLLEAGAD 268
            +  TAL  A  +G  +V+  LL     +    K G + L  A   G  +   +LL+ GAD
Sbjct: 1223 NRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1282

Query: 269  ------PSLRNKANELPAE 281
                  PS R+ A  + A+
Sbjct: 1283 VNAPPVPSSRDTALTIAAD 1301



 Score =  100 bits (250), Expect = 1e-21
 Identities = 84/257 (32%), Positives = 134/257 (52%), Gaps = 8/257 (3%)

Query: 19   AARRGNLALLKLLLNSGRVDVDCRDSHGT-TLLMVAAYAGHIDCVRELVLQGADINLQRE 77
            AA  G++ ++++LL+ G  D++ +      T L +A   G  + V  L+ +GA+   +  
Sbjct: 1095 AATAGHVGVVEILLDKGG-DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 1153

Query: 78   SGTTALFFAAQQGHNDVVRFLFGFGASTEFRT--KDGGTALLAASQYGHMQVVETLLKHG 135
            S  T L  AA  G+ ++++ L   GA    RT  K G + L+ A+  GH+  V+ LL  G
Sbjct: 1154 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213

Query: 136  ANIHDQLYDGA-TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVV 194
            ++I+ Q+     TAL LA   G  +V+ LLL   A V    + G  PL  A+  G++EV 
Sbjct: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273

Query: 195  RVMLLRGADRDA--ARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAV 251
            RV+L +GAD +A    +   TAL  AA+KG+    + L+     + +  K G + L  A 
Sbjct: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333

Query: 252  LSGNIKTVALLLEAGAD 268
              G+   V LL++AGAD
Sbjct: 1334 NGGHFDVVQLLVQAGAD 1350



 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 44/125 (35%), Positives = 64/125 (51%), Gaps = 2/125 (1%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A  +A   G+  +  +LL +G  D++     G T LM AA AGH+  V+ L+ +GA++N 
Sbjct: 571 ALTYACENGHTDVADVLLQAG-ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629

Query: 75  QRESGT-TALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
              +   T +  A   GH  VV  L   GA    R KDG T L+ A++ GH  VV  LL 
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689

Query: 134 HGANI 138
           +  N+
Sbjct: 690 YPNNV 694



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 42/145 (28%), Positives = 69/145 (47%), Gaps = 2/145 (1%)

Query: 137 NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRV 196
           N H+       +L  A   G ++ +R LL  G  VN+  ++G + L +A   G+ E+ +V
Sbjct: 197 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256

Query: 197 MLLRGADRDAARNDG-TTALLKAANKGYNDVIKELLKFSPTLGILK-NGTSALHAAVLSG 254
           +L   A+ +   N G  T L+ A++ GY D++K LL     +      G +AL  A   G
Sbjct: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316

Query: 255 NIKTVALLLEAGADPSLRNKANELP 279
            +  V +LL  GA+    N+    P
Sbjct: 317 FVDIVKVLLNEGANIEDHNENGHTP 341



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 39/147 (26%), Positives = 63/147 (42%), Gaps = 31/147 (21%)

Query: 147  TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDA 206
            TAL LA  GG+ +++ +L+A  AK+    + G  PL +A+  GH  VV ++L +G D +A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 207  ARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAG 266
                                  E  K +P           L  A   G  + V LLL  G
Sbjct: 1117 Q--------------------SERTKDTP-----------LSLACSGGRQEVVDLLLARG 1145

Query: 267  ADPSLRNKANELPAELTKNERILRLLR 293
            A+   RN ++  P  L  +   + +++
Sbjct: 1146 ANKEHRNVSDYTPLSLAASGGYVNIIK 1172



 Score = 32.3 bits (72), Expect = 0.53
 Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 2/54 (3%)

Query: 14   NAAFW-AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV 66
            N   W A+  G+  +++LL+ +G  DVD  D+   T LM A   GH+  V+ LV
Sbjct: 1326 NTPLWLASNGGHFDVVQLLVQAG-ADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  124 bits (312), Expect = 8e-29
 Identities = 94/290 (32%), Positives = 142/290 (48%), Gaps = 38/290 (13%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGT-TLLMVAAYAGHIDCVRELVLQGADINLQRE 77
           A   G   L ++LL +   +V+ R   G  T LM AA  GH+  V+ L+   AD+N Q  
Sbjct: 274 ACSAGYYELAQVLL-AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSS 332

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
           +G TAL +A   G+ DVV+ L   GAS E   ++G T L+ A   GH++V   LL++GA 
Sbjct: 333 TGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAG 392

Query: 138 IHDQ------------------------LYDGA----------TALFLAAQGGYLDVIRL 163
           I+                          L  GA          TAL  A   G+++V RL
Sbjct: 393 INTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 452

Query: 164 LLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGY 223
           LL SGA+VN P     +PL +A+  GH E+  +++ RGA  +   ++G T L++AA +G+
Sbjct: 453 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGH 512

Query: 224 NDVIKELLKFSPTLGILKNGT--SALHAAVLSGNIKTVALLLEAGADPSL 271
            +++  LL     +      T  +AL  A   G ++    L++AGAD  L
Sbjct: 513 EEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL 562



 Score =  122 bits (306), Expect = 4e-28
 Identities = 88/270 (32%), Positives = 139/270 (51%), Gaps = 7/270 (2%)

Query: 8   KETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVL 67
           K   +  A   A   G++ + +LLL+SG   V+       + L +AA  GH++    L+ 
Sbjct: 430 KTDEMHTALMEACMDGHVEVARLLLDSG-AQVNMPADSFESPLTLAACGGHVELAALLIE 488

Query: 68  QGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGG-TALLAASQYGHMQ 126
           +GA +    + G T L  AA++GH ++V  L G GA+   +T++   TAL  A   G ++
Sbjct: 489 RGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLE 548

Query: 127 VVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIAS 186
           V + L+K GA+I       +T L  AAQ G+L++++ LLA+GA V+     G   L  A 
Sbjct: 549 VADFLIKAGADIE---LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYAC 605

Query: 187 QMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLG--ILKNGT 244
           + GH++V  V+L  GAD +     G T L+KAA  G+   ++ L+     +      N  
Sbjct: 606 ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDH 665

Query: 245 SALHAAVLSGNIKTVALLLEAGADPSLRNK 274
           + L  A   G++  V LLL  GADP+ R K
Sbjct: 666 TVLSLACAGGHLAVVELLLAHGADPTHRLK 695



 Score =  122 bits (306), Expect = 4e-28
 Identities = 81/219 (36%), Positives = 123/219 (56%), Gaps = 6/219 (2%)

Query: 19   AARRGNLALLKLLLNSGRVDVDCRDSH--GTTLLMVAAYAGHIDCVRELVLQGADINLQR 76
            AA  G + ++K+LLN+G  +++ R     G + LM+AA  GH   V+ L+  G+DIN Q 
Sbjct: 1190 AASGGYVNIIKILLNAG-AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI 1248

Query: 77   ESG-TTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHG 135
            E+   TAL  A  QG  +VV  L    A+ E R K G T L+ A+  G+ +V   LL  G
Sbjct: 1249 ETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG 1308

Query: 136  ANIHDQLYDGA--TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            A+++      +  TAL +AA  G+     LL+  GA ++   + G  PLW+A+  GH +V
Sbjct: 1309 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDV 1368

Query: 194  VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLK 232
            V++++  GAD DAA N   T L+ A  KG+  V++ L+K
Sbjct: 1369 VQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score =  121 bits (304), Expect = 7e-28
 Identities = 86/256 (33%), Positives = 138/256 (53%), Gaps = 5/256 (1%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A  +A   G + ++K+LL SG   ++  + +G T LM A  AGH++  R L+  GA IN 
Sbjct: 337 ALTYACAGGYVDVVKVLLESG-ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINT 395

Query: 75  Q-RESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
              E   +AL  A  +GH ++VRFL   GA  E +T +  TAL+ A   GH++V   LL 
Sbjct: 396 HSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 455

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            GA ++       + L LAA GG++++  LL+  GA + +   +G  PL  A++ GH E+
Sbjct: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515

Query: 194 VRVMLLRGADRDAARND-GTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVL 252
           V ++L +GA+ +A   +   TAL  A   G+ +V   L+K    + +    ++ L  A  
Sbjct: 516 VALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL--GCSTPLMEAAQ 573

Query: 253 SGNIKTVALLLEAGAD 268
            G+++ V  LL AGA+
Sbjct: 574 EGHLELVKYLLAAGAN 589



 Score =  120 bits (302), Expect = 1e-27
 Identities = 77/239 (32%), Positives = 130/239 (54%), Gaps = 9/239 (3%)

Query: 50  LMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRT 109
           L  A   G ++ VR+L+++G  +N   E G + L  A   G+ ++ + L    A+ E R 
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297

Query: 110 KDGG-TALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASG 168
             G  T L+AA+  GH+++V+ LL H A+++ Q   G TAL  A  GGY+DV+++LL SG
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357

Query: 169 AKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARND-GTTALLKAANKGYNDVI 227
           A +    ++G  PL  A   GH EV R++L  GA  +   N+   +AL  A  KG+ +++
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 417

Query: 228 KELLKFSPTLGILKNGTSALHAAV----LSGNIKTVALLLEAGADPSLRNKANELPAEL 282
           + LL+        ++ T  +H A+    + G+++   LLL++GA  ++   + E P  L
Sbjct: 418 RFLLEAGAD---QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473



 Score =  114 bits (285), Expect = 1e-25
 Identities = 90/259 (34%), Positives = 133/259 (51%), Gaps = 16/259 (6%)

Query: 37   VDVDCR-DSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVV 95
            +D+D + +S+  T L +A   GH + V+ L+ +GA I  + + G T L  AA  GH  VV
Sbjct: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132

Query: 96   RFLFGFGASTEF---RTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLA 152
              L   GA  E    RTKD  T L  A   G  +VVE LL  GAN   +     T L LA
Sbjct: 1133 EILLDNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLA 1190

Query: 153  AQGGYLDVIRLLLASGAKVNQPRQD--GTAPLWIASQMGHSEVVRVMLLRGADRDA-ARN 209
            A GGY+++I++LL +GA++N       G +PL +A+  GH+  V+++L  G+D +A    
Sbjct: 1191 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIET 1250

Query: 210  DGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAAVLSGNIKTVALLLEAGAD 268
            +  TAL  A  +G  +V+  LL     +    K G + L  A   G  +   +LL+ GAD
Sbjct: 1251 NRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1310

Query: 269  ------PSLRNKANELPAE 281
                  PS R+ A  + A+
Sbjct: 1311 VNAPPVPSSRDTALTIAAD 1329



 Score =  112 bits (280), Expect = 4e-25
 Identities = 92/251 (36%), Positives = 129/251 (51%), Gaps = 11/251 (4%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQ-RE 77
           AA  G++ L  LL+  G    +  D  G T LM AA  GH + V  L+ QGA+IN Q  E
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDE-GYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
           +  TAL  A   G  +V  FL   GA  E       T L+ A+Q GH+++V+ LL  GAN
Sbjct: 533 TQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGAN 589

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVM 197
           +H     G TAL  A + G+ DV  +LL +GA +    + G  PL  A++ GH   V+ +
Sbjct: 590 VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649

Query: 198 LLRGA--DRDAARNDGTTALLKAANKGYNDVIKELLKF--SPTLGILKNGTSALHAAVLS 253
           + +GA  +R  A ND T   L  A  G+  V++ LL     PT   LK+G++ L  A   
Sbjct: 650 ISKGANVNRTTANNDHTVLSLACAG-GHLAVVELLLAHGADPT-HRLKDGSTMLIEAAKG 707

Query: 254 GNIKTVALLLE 264
           G+   V  LL+
Sbjct: 708 GHTSVVCYLLD 718



 Score =  112 bits (279), Expect = 5e-25
 Identities = 74/221 (33%), Positives = 116/221 (52%), Gaps = 6/221 (2%)

Query: 19  AARRGNLALLKLLLNSG-RVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
           AAR G+  ++ LLL  G  ++    ++  T L + A   G ++    L+  GADI L   
Sbjct: 507 AAREGHEEMVALLLGQGANINAQTEETQETALTL-ACCGGFLEVADFLIKAGADIEL--- 562

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
             +T L  AAQ+GH ++V++L   GA+    T  G TAL  A + GH  V + LL+ GA+
Sbjct: 563 GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 622

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGT-APLWIASQMGHSEVVRV 196
           +  +   G T L  AA+ G++  ++ L++ GA VN+   +     L +A   GH  VV +
Sbjct: 623 LEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVEL 682

Query: 197 MLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL 237
           +L  GAD      DG+T L++AA  G+  V+  LL +   L
Sbjct: 683 LLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNL 723



 Score =  103 bits (258), Expect = 1e-22
 Identities = 93/290 (32%), Positives = 136/290 (46%), Gaps = 41/290 (14%)

Query: 19   AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE- 77
            A   G+  L++ LL  G   ++ RD  G T L++AA AGH+  V  L+  GADI  Q E 
Sbjct: 1090 ACAGGHEELVQTLLERG-ASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 1148

Query: 78   ---------------------------------SGTTALFFAAQQGHNDVVRFLFGFGAS 104
                                             S  T L  AA  G+ ++++ L   GA 
Sbjct: 1149 TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 1208

Query: 105  TEFRT--KDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGA-TALFLAAQGGYLDVI 161
               RT  K G + L+ A+  GH   V+ LL  G++I+ Q+     TAL LA   G  +V+
Sbjct: 1209 INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1268

Query: 162  RLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDA--ARNDGTTALLKAA 219
             LLL   A V    + G  PL  A+  G++EV RV+L +GAD +A    +   TAL  AA
Sbjct: 1269 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAA 1328

Query: 220  NKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIKTVALLLEAGAD 268
            +KG+    + L+     + +  K G + L  A   G++  V LL++AGAD
Sbjct: 1329 DKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1378



 Score = 77.4 bits (189), Expect = 1e-14
 Identities = 54/166 (32%), Positives = 85/166 (51%), Gaps = 2/166 (1%)

Query: 104 STEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRL 163
           ST    +    +L  A   G +  V  LL  G ++++   +G + L LA   GY ++ ++
Sbjct: 226 STANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQV 285

Query: 164 LLASGAKVNQPRQDG-TAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKG 222
           LLA  A V      G   PL  A+  GH ++V+++L   AD +A  + G TAL  A   G
Sbjct: 286 LLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGG 345

Query: 223 YNDVIKELLKFSPTL-GILKNGTSALHAAVLSGNIKTVALLLEAGA 267
           Y DV+K LL+   ++    +NG + L  A  +G+++   LLLE GA
Sbjct: 346 YVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGA 391



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 45/125 (36%), Positives = 64/125 (51%), Gaps = 2/125 (1%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A  +A   G+  +  +LL +G  D++     G T LM AA AGH+  V+ L+ +GA++N 
Sbjct: 600 ALTYACENGHTDVADVLLQAG-ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658

Query: 75  QRESGT-TALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
              +   T L  A   GH  VV  L   GA    R KDG T L+ A++ GH  VV  LL 
Sbjct: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718

Query: 134 HGANI 138
           +  N+
Sbjct: 719 YPNNL 723



 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 40/147 (27%), Positives = 62/147 (42%), Gaps = 31/147 (21%)

Query: 147  TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDA 206
            TAL LA  GG+ ++++ LL  GA +    + G  PL +A+  GH  VV ++L  GAD +A
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 207  ARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAG 266
                                  E  K +P           L  A   G  + V LLL  G
Sbjct: 1145 Q--------------------SERTKDTP-----------LSLACSGGRQEVVELLLARG 1173

Query: 267  ADPSLRNKANELPAELTKNERILRLLR 293
            A+   RN ++  P  L  +   + +++
Sbjct: 1174 ANKEHRNVSDYTPLSLAASGGYVNIIK 1200



 Score = 37.4 bits (85), Expect = 0.016
 Identities = 23/54 (42%), Positives = 31/54 (57%), Gaps = 2/54 (3%)

Query: 14   NAAFW-AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV 66
            N   W AA  G+L +++LL+ +G  DVD  D+   T LM A   GH+  VR LV
Sbjct: 1354 NTPLWLAANGGHLDVVQLLVQAG-ADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score =  124 bits (312), Expect = 8e-29
 Identities = 94/290 (32%), Positives = 142/290 (48%), Gaps = 38/290 (13%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGT-TLLMVAAYAGHIDCVRELVLQGADINLQRE 77
           A   G   L ++LL +   +V+ R   G  T LM AA  GH+  V+ L+   AD+N Q  
Sbjct: 274 ACSAGYYELAQVLL-AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSS 332

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
           +G TAL +A   G+ DVV+ L   GAS E   ++G T L+ A   GH++V   LL++GA 
Sbjct: 333 TGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAG 392

Query: 138 IHDQ------------------------LYDGA----------TALFLAAQGGYLDVIRL 163
           I+                          L  GA          TAL  A   G+++V RL
Sbjct: 393 INTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 452

Query: 164 LLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGY 223
           LL SGA+VN P     +PL +A+  GH E+  +++ RGA  +   ++G T L++AA +G+
Sbjct: 453 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGH 512

Query: 224 NDVIKELLKFSPTLGILKNGT--SALHAAVLSGNIKTVALLLEAGADPSL 271
            +++  LL     +      T  +AL  A   G ++    L++AGAD  L
Sbjct: 513 EEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL 562



 Score =  122 bits (306), Expect = 4e-28
 Identities = 88/270 (32%), Positives = 139/270 (51%), Gaps = 7/270 (2%)

Query: 8   KETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVL 67
           K   +  A   A   G++ + +LLL+SG   V+       + L +AA  GH++    L+ 
Sbjct: 430 KTDEMHTALMEACMDGHVEVARLLLDSG-AQVNMPADSFESPLTLAACGGHVELAALLIE 488

Query: 68  QGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGG-TALLAASQYGHMQ 126
           +GA +    + G T L  AA++GH ++V  L G GA+   +T++   TAL  A   G ++
Sbjct: 489 RGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLE 548

Query: 127 VVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIAS 186
           V + L+K GA+I       +T L  AAQ G+L++++ LLA+GA V+     G   L  A 
Sbjct: 549 VADFLIKAGADIE---LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYAC 605

Query: 187 QMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLG--ILKNGT 244
           + GH++V  V+L  GAD +     G T L+KAA  G+   ++ L+     +      N  
Sbjct: 606 ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDH 665

Query: 245 SALHAAVLSGNIKTVALLLEAGADPSLRNK 274
           + L  A   G++  V LLL  GADP+ R K
Sbjct: 666 TVLSLACAGGHLAVVELLLAHGADPTHRLK 695



 Score =  122 bits (306), Expect = 4e-28
 Identities = 81/219 (36%), Positives = 123/219 (56%), Gaps = 6/219 (2%)

Query: 19   AARRGNLALLKLLLNSGRVDVDCRDSH--GTTLLMVAAYAGHIDCVRELVLQGADINLQR 76
            AA  G + ++K+LLN+G  +++ R     G + LM+AA  GH   V+ L+  G+DIN Q 
Sbjct: 939  AASGGYVNIIKILLNAG-AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI 997

Query: 77   ESG-TTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHG 135
            E+   TAL  A  QG  +VV  L    A+ E R K G T L+ A+  G+ +V   LL  G
Sbjct: 998  ETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKG 1057

Query: 136  ANIHDQLYDGA--TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            A+++      +  TAL +AA  G+     LL+  GA ++   + G  PLW+A+  GH +V
Sbjct: 1058 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDV 1117

Query: 194  VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLK 232
            V++++  GAD DAA N   T L+ A  KG+  V++ L+K
Sbjct: 1118 VQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156



 Score =  121 bits (304), Expect = 7e-28
 Identities = 86/256 (33%), Positives = 138/256 (53%), Gaps = 5/256 (1%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A  +A   G + ++K+LL SG   ++  + +G T LM A  AGH++  R L+  GA IN 
Sbjct: 337 ALTYACAGGYVDVVKVLLESG-ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINT 395

Query: 75  Q-RESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
              E   +AL  A  +GH ++VRFL   GA  E +T +  TAL+ A   GH++V   LL 
Sbjct: 396 HSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 455

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
            GA ++       + L LAA GG++++  LL+  GA + +   +G  PL  A++ GH E+
Sbjct: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515

Query: 194 VRVMLLRGADRDAARND-GTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVL 252
           V ++L +GA+ +A   +   TAL  A   G+ +V   L+K    + +    ++ L  A  
Sbjct: 516 VALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL--GCSTPLMEAAQ 573

Query: 253 SGNIKTVALLLEAGAD 268
            G+++ V  LL AGA+
Sbjct: 574 EGHLELVKYLLAAGAN 589



 Score =  120 bits (302), Expect = 1e-27
 Identities = 77/239 (32%), Positives = 130/239 (54%), Gaps = 9/239 (3%)

Query: 50  LMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRT 109
           L  A   G ++ VR+L+++G  +N   E G + L  A   G+ ++ + L    A+ E R 
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297

Query: 110 KDGG-TALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASG 168
             G  T L+AA+  GH+++V+ LL H A+++ Q   G TAL  A  GGY+DV+++LL SG
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357

Query: 169 AKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARND-GTTALLKAANKGYNDVI 227
           A +    ++G  PL  A   GH EV R++L  GA  +   N+   +AL  A  KG+ +++
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 417

Query: 228 KELLKFSPTLGILKNGTSALHAAV----LSGNIKTVALLLEAGADPSLRNKANELPAEL 282
           + LL+        ++ T  +H A+    + G+++   LLL++GA  ++   + E P  L
Sbjct: 418 RFLLEAGAD---QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473



 Score =  114 bits (285), Expect = 1e-25
 Identities = 90/259 (34%), Positives = 133/259 (51%), Gaps = 16/259 (6%)

Query: 37   VDVDCR-DSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVV 95
            +D+D + +S+  T L +A   GH + V+ L+ +GA I  + + G T L  AA  GH  VV
Sbjct: 822  IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 881

Query: 96   RFLFGFGASTEF---RTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLA 152
              L   GA  E    RTKD  T L  A   G  +VVE LL  GAN   +     T L LA
Sbjct: 882  EILLDNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLA 939

Query: 153  AQGGYLDVIRLLLASGAKVNQPRQD--GTAPLWIASQMGHSEVVRVMLLRGADRDA-ARN 209
            A GGY+++I++LL +GA++N       G +PL +A+  GH+  V+++L  G+D +A    
Sbjct: 940  ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIET 999

Query: 210  DGTTALLKAANKGYNDVIKELLKFSPTL-GILKNGTSALHAAVLSGNIKTVALLLEAGAD 268
            +  TAL  A  +G  +V+  LL     +    K G + L  A   G  +   +LL+ GAD
Sbjct: 1000 NRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1059

Query: 269  ------PSLRNKANELPAE 281
                  PS R+ A  + A+
Sbjct: 1060 VNAPPVPSSRDTALTIAAD 1078



 Score =  112 bits (280), Expect = 4e-25
 Identities = 92/251 (36%), Positives = 129/251 (51%), Gaps = 11/251 (4%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQ-RE 77
           AA  G++ L  LL+  G    +  D  G T LM AA  GH + V  L+ QGA+IN Q  E
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDE-GYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
           +  TAL  A   G  +V  FL   GA  E       T L+ A+Q GH+++V+ LL  GAN
Sbjct: 533 TQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGAN 589

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVM 197
           +H     G TAL  A + G+ DV  +LL +GA +    + G  PL  A++ GH   V+ +
Sbjct: 590 VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649

Query: 198 LLRGA--DRDAARNDGTTALLKAANKGYNDVIKELLKF--SPTLGILKNGTSALHAAVLS 253
           + +GA  +R  A ND T   L  A  G+  V++ LL     PT   LK+G++ L  A   
Sbjct: 650 ISKGANVNRTTANNDHTVLSLACAG-GHLAVVELLLAHGADPT-HRLKDGSTMLIEAAKG 707

Query: 254 GNIKTVALLLE 264
           G+   V  LL+
Sbjct: 708 GHTSVVCYLLD 718



 Score =  112 bits (279), Expect = 5e-25
 Identities = 74/221 (33%), Positives = 116/221 (52%), Gaps = 6/221 (2%)

Query: 19  AARRGNLALLKLLLNSG-RVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
           AAR G+  ++ LLL  G  ++    ++  T L + A   G ++    L+  GADI L   
Sbjct: 507 AAREGHEEMVALLLGQGANINAQTEETQETALTL-ACCGGFLEVADFLIKAGADIEL--- 562

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
             +T L  AAQ+GH ++V++L   GA+    T  G TAL  A + GH  V + LL+ GA+
Sbjct: 563 GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 622

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGT-APLWIASQMGHSEVVRV 196
           +  +   G T L  AA+ G++  ++ L++ GA VN+   +     L +A   GH  VV +
Sbjct: 623 LEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVEL 682

Query: 197 MLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL 237
           +L  GAD      DG+T L++AA  G+  V+  LL +   L
Sbjct: 683 LLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNL 723



 Score =  103 bits (258), Expect = 1e-22
 Identities = 93/290 (32%), Positives = 136/290 (46%), Gaps = 41/290 (14%)

Query: 19   AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE- 77
            A   G+  L++ LL  G   ++ RD  G T L++AA AGH+  V  L+  GADI  Q E 
Sbjct: 839  ACAGGHEELVQTLLERG-ASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 897

Query: 78   ---------------------------------SGTTALFFAAQQGHNDVVRFLFGFGAS 104
                                             S  T L  AA  G+ ++++ L   GA 
Sbjct: 898  TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 957

Query: 105  TEFRT--KDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGA-TALFLAAQGGYLDVI 161
               RT  K G + L+ A+  GH   V+ LL  G++I+ Q+     TAL LA   G  +V+
Sbjct: 958  INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1017

Query: 162  RLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDA--ARNDGTTALLKAA 219
             LLL   A V    + G  PL  A+  G++EV RV+L +GAD +A    +   TAL  AA
Sbjct: 1018 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAA 1077

Query: 220  NKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIKTVALLLEAGAD 268
            +KG+    + L+     + +  K G + L  A   G++  V LL++AGAD
Sbjct: 1078 DKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1127



 Score = 77.4 bits (189), Expect = 1e-14
 Identities = 54/166 (32%), Positives = 85/166 (51%), Gaps = 2/166 (1%)

Query: 104 STEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRL 163
           ST    +    +L  A   G +  V  LL  G ++++   +G + L LA   GY ++ ++
Sbjct: 226 STANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQV 285

Query: 164 LLASGAKVNQPRQDG-TAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKG 222
           LLA  A V      G   PL  A+  GH ++V+++L   AD +A  + G TAL  A   G
Sbjct: 286 LLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGG 345

Query: 223 YNDVIKELLKFSPTL-GILKNGTSALHAAVLSGNIKTVALLLEAGA 267
           Y DV+K LL+   ++    +NG + L  A  +G+++   LLLE GA
Sbjct: 346 YVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGA 391



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 45/125 (36%), Positives = 64/125 (51%), Gaps = 2/125 (1%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A  +A   G+  +  +LL +G  D++     G T LM AA AGH+  V+ L+ +GA++N 
Sbjct: 600 ALTYACENGHTDVADVLLQAG-ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658

Query: 75  QRESGT-TALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
              +   T L  A   GH  VV  L   GA    R KDG T L+ A++ GH  VV  LL 
Sbjct: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718

Query: 134 HGANI 138
           +  N+
Sbjct: 719 YPNNL 723



 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 40/147 (27%), Positives = 62/147 (42%), Gaps = 31/147 (21%)

Query: 147 TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDA 206
           TAL LA  GG+ ++++ LL  GA +    + G  PL +A+  GH  VV ++L  GAD +A
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893

Query: 207 ARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAG 266
                                 E  K +P           L  A   G  + V LLL  G
Sbjct: 894 Q--------------------SERTKDTP-----------LSLACSGGRQEVVELLLARG 922

Query: 267 ADPSLRNKANELPAELTKNERILRLLR 293
           A+   RN ++  P  L  +   + +++
Sbjct: 923 ANKEHRNVSDYTPLSLAASGGYVNIIK 949



 Score = 37.4 bits (85), Expect = 0.016
 Identities = 23/54 (42%), Positives = 31/54 (57%), Gaps = 2/54 (3%)

Query: 14   NAAFW-AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV 66
            N   W AA  G+L +++LL+ +G  DVD  D+   T LM A   GH+  VR LV
Sbjct: 1103 NTPLWLAANGGHLDVVQLLVQAG-ADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155


>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
           sapiens]
          Length = 587

 Score =  123 bits (308), Expect = 2e-28
 Identities = 79/258 (30%), Positives = 128/258 (49%), Gaps = 4/258 (1%)

Query: 11  PLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGA 70
           PL  AA++    G +  LK+L  +    +D R     T + +A   GH+DC+  L+  GA
Sbjct: 93  PLHEAAYY----GQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGA 148

Query: 71  DINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVET 130
           + ++  +S  T L+ A ++ + + V+ L    A T  R   G TAL  +     ++V++ 
Sbjct: 149 EPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQI 208

Query: 131 LLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGH 190
           L+  GA +  +   G T LF+AAQ G L+ +R L   GA +N    D  + L+ A +  H
Sbjct: 209 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH 268

Query: 191 SEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAA 250
            EVV  +L +GAD +    DG   L  A+ KG   +++ LL  +    I ++G S LH A
Sbjct: 269 EEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLA 328

Query: 251 VLSGNIKTVALLLEAGAD 268
               + + +  LL A  D
Sbjct: 329 AERNHDEVLEALLSARFD 346



 Score =  120 bits (301), Expect = 1e-27
 Identities = 87/266 (32%), Positives = 137/266 (51%), Gaps = 12/266 (4%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A + A  RG+L  L  LL +G  + D  +    T L  A    + + V+ LV   AD N 
Sbjct: 127 AVYLATCRGHLDCLLSLLQAG-AEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNH 185

Query: 75  QRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKH 134
           +   G TAL  +  +   +V++ L   GA  E +   G T L  A+Q G ++ +  L K+
Sbjct: 186 RCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKY 245

Query: 135 GANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVV 194
           GA+I+ Q  D A+AL+ A +  + +V+  LL+ GA  N+  +DG  PL IAS+ G+  +V
Sbjct: 246 GADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIV 305

Query: 195 RVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLK--------FSPTLGILKNG--T 244
           + MLL    R   R  G + L  AA + +++V++ LL          +P    L     +
Sbjct: 306 Q-MLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRS 364

Query: 245 SALHAAVLSGNIKTVALLLEAGADPS 270
           SAL+ AV++ N+    LLL+ GADP+
Sbjct: 365 SALYFAVVNNNVYATELLLQHGADPN 390



 Score = 99.4 bits (246), Expect = 4e-21
 Identities = 80/284 (28%), Positives = 136/284 (47%), Gaps = 10/284 (3%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGA---DINLQ 75
           A + G+   LK ++  G+ ++   +  G   L  AAY G + C++  VLQ A    I+ +
Sbjct: 64  AIKDGDEEALKTMIKEGK-NLAEPNKEGWLPLHEAAYYGQVGCLK--VLQRAYPGTIDQR 120

Query: 76  RESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHG 135
                TA++ A  +GH D +  L   GA  +   K   T L  A +  + + V+ L++H 
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180

Query: 136 ANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVR 195
           A+ + +   G TAL  +     L+V+++L++ GAKV      G  PL++A+Q G  E +R
Sbjct: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240

Query: 196 VMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSG 254
            +   GAD +   +D  +AL +A    + +V++ LL          K+G   LH A   G
Sbjct: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKG 300

Query: 255 NIKTVALLLEAGADPSLRNKA---NELPAELTKNERILRLLRSK 295
           N + V +LL   +   +R        L AE   +E +  LL ++
Sbjct: 301 NYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSAR 344



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 62/224 (27%), Positives = 104/224 (46%), Gaps = 41/224 (18%)

Query: 22  RGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTT 81
           R +L ++++L+ SG   V+ ++++G T L VAA +G ++ +R L   GADIN Q     +
Sbjct: 200 RNDLEVMQILV-SGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNAS 258

Query: 82  ALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQ 141
           AL+ A +  H +VV FL   GA      KDG   L  AS+ G+ ++V+ LL   +    +
Sbjct: 259 ALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR 318

Query: 142 LYDGATALFLAAQGGYLDVIRLLLASGAKVN----------------------------- 172
              G + L LAA+  + +V+  LL++   VN                             
Sbjct: 319 R-SGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVY 377

Query: 173 ----------QPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDA 206
                      P +D  +PL +A + G    ++++L  GA+ DA
Sbjct: 378 ATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDA 421



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 6/103 (5%)

Query: 181 PLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL 240
           PL  A + G  E ++ M+  G +      +G   L +AA  G    +K L +  P  G +
Sbjct: 60  PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYP--GTI 117

Query: 241 KNGT----SALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
              T    +A++ A   G++  +  LL+AGA+P + NK+ E P
Sbjct: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETP 160



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 36/140 (25%), Positives = 65/140 (46%), Gaps = 16/140 (11%)

Query: 19  AARRGNLALLKLLLN-SGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADIN---- 73
           A+++GN  ++++LL  + R  +      G + L +AA   H + +  L+    D+N    
Sbjct: 296 ASKKGNYRIVQMLLPVTSRTRIR---RSGVSPLHLAAERNHDEVLEALLSARFDVNTPLA 352

Query: 74  -----LQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVV 128
                L  +  ++AL+FA    +      L   GA      +D  + LL A ++G ++ +
Sbjct: 353 PERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTM 409

Query: 129 ETLLKHGANIHDQLYDGATA 148
           + LL HGANI   +    TA
Sbjct: 410 QLLLDHGANIDAYIATHPTA 429


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  120 bits (302), Expect = 1e-27
 Identities = 86/268 (32%), Positives = 137/268 (51%), Gaps = 5/268 (1%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A  WAA  G++ ++KLL++ G  +V C+D    T L  AA +G I  V+ L+  G D+N 
Sbjct: 176 AIHWAAYMGHIEVVKLLVSHG-AEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNE 234

Query: 75  QRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTAL--LAASQYGHMQVVETLL 132
               G T L  A   G + VV  L   GA    + + G T L   AAS +G +  +E L+
Sbjct: 235 PNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL-CLELLV 293

Query: 133 KHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSE 192
            +GA+++ +  DG T L + A  G     + ++ SGA ++   ++G  PL IA++ GH  
Sbjct: 294 GNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHEL 353

Query: 193 VVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKN-GTSALHAAV 251
           ++  ++  GAD       G   L  AA  G++D  ++LL     +    + G + LHAA 
Sbjct: 354 LINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAA 413

Query: 252 LSGNIKTVALLLEAGADPSLRNKANELP 279
             GN++ + LLL  GAD + ++K    P
Sbjct: 414 AGGNLECLNLLLNTGADFNKKDKFGRSP 441



 Score =  107 bits (267), Expect = 1e-23
 Identities = 88/276 (31%), Positives = 132/276 (47%), Gaps = 7/276 (2%)

Query: 9   ETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQ 68
           +TPL  AA   A +   AL+ LL N     V+  D  G T L  AA++GH + V+ L+ +
Sbjct: 108 QTPLHIAAANKAVKCAEALVPLLSN-----VNVSDRAGRTALHHAAFSGHGEMVKLLLSR 162

Query: 69  GADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVV 128
           GA+IN   +    A+ +AA  GH +VV+ L   GA    + K   T L AA+  G + VV
Sbjct: 163 GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVV 222

Query: 129 ETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQM 188
           + LL  G ++++    G T L +A   G   V+  L+  GA VNQ  + G  PL  A+  
Sbjct: 223 KYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAAS 282

Query: 189 GHSEVVRVMLL-RGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSA 246
            H  +   +L+  GAD +    DG T L   A  G     + +++    +    KNG + 
Sbjct: 283 THGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTP 342

Query: 247 LHAAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
           LH A   G+   +  L+ +GAD + R      P  L
Sbjct: 343 LHIAARYGHELLINTLITSGADTAKRGIHGMFPLHL 378



 Score =  104 bits (260), Expect = 8e-23
 Identities = 84/257 (32%), Positives = 129/257 (50%), Gaps = 15/257 (5%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE- 77
           AA  G+   L++L+ S  +D+D R+S G T L +AA+ GH++CV  L+ QGA I ++   
Sbjct: 557 AAYHGHHQALEVLVQS-LLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYI 615

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGA---STEFRTKDGGTALLAASQYGHMQVVETLLKH 134
              T +  AA  GH++ +R L G      + + +  +G T L+ +   GH   V +LL  
Sbjct: 616 LKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675

Query: 135 GANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVV 194
           GAN+  +   G TAL   A  G+ + +  LL  GAK       G  P+ +++  GH  V+
Sbjct: 676 GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL 735

Query: 195 RVMLLRGADRDA----ARNDGTTALLKAANKGYNDVIKELLK---FSPTLGILKNGTSAL 247
             +L   A  DA    A N G TAL  A   G+   ++ LL+   F  T G   N  S L
Sbjct: 736 GALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG---NAFSPL 792

Query: 248 HAAVLSGNIKTVALLLE 264
           H AV++ N     +L++
Sbjct: 793 HCAVINDNEGAAEMLID 809



 Score =  103 bits (258), Expect = 1e-22
 Identities = 80/275 (29%), Positives = 122/275 (44%), Gaps = 7/275 (2%)

Query: 10  TPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQG 69
           TPL  A    +      LLK        DV+ RD +  T L +AA    + C   LV   
Sbjct: 76  TPLHRAVASCSEEAVQVLLK-----HSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130

Query: 70  ADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVE 129
           +++N+   +G TAL  AA  GH ++V+ L   GA+     K    A+  A+  GH++VV+
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190

Query: 130 TLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMG 189
            L+ HGA +  +     T L  AA  G + V++ LL  G  +N+P   G  PL +A   G
Sbjct: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250

Query: 190 HSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELL--KFSPTLGILKNGTSAL 247
              VV  ++  GA  +     G T L  AA   +  +  ELL    +      K+G + L
Sbjct: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310

Query: 248 HAAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
           H   L G       ++++GA     +K    P  +
Sbjct: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345



 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 76/248 (30%), Positives = 119/248 (47%), Gaps = 11/248 (4%)

Query: 38  DVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRF 97
           DV+ +D+   T L  AAY G  + +  L+L GA +N +     T L  A      + V+ 
Sbjct: 33  DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQV 92

Query: 98  LFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGY 157
           L    A    R K+  T L  A+    ++  E L+   +N++     G TAL  AA  G+
Sbjct: 93  LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH 152

Query: 158 LDVIRLLLASGAKVNQ-PRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALL 216
            ++++LLL+ GA +N   ++D  A  W A+ MGH EVV++++  GA+         T L 
Sbjct: 153 GEMVKLLLSRGANINAFDKKDRRAIHW-AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLH 211

Query: 217 KAANKGYNDVIKELLKFSPTLGILKN-----GTSALHAAVLSGNIKTVALLLEAGADPSL 271
            AA+ G   V+K LL     LG+  N     G + LH A  +G    V  L++ GA  + 
Sbjct: 212 AAASSGMISVVKYLL----DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQ 267

Query: 272 RNKANELP 279
           +N+    P
Sbjct: 268 KNEKGFTP 275



 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 84/292 (28%), Positives = 132/292 (45%), Gaps = 37/292 (12%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGH-------IDC---------- 61
           AA  G ++++K LL+ G VD++  +++G T L VA Y G        IDC          
Sbjct: 213 AASSGMISVVKYLLDLG-VDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEK 271

Query: 62  -----------------VRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGAS 104
                            +  LV  GAD+N++ + G T L   A  G     + +   GA 
Sbjct: 272 GFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAV 331

Query: 105 TEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLL 164
            +   K+G T L  A++YGH  ++ TL+  GA+   +   G   L LAA  G+ D  R L
Sbjct: 332 IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKL 391

Query: 165 LASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTAL-LKAANKGY 223
           L+SG  ++ P   G   L  A+  G+ E + ++L  GAD +     G + L   AAN  Y
Sbjct: 392 LSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNY 451

Query: 224 NDVIKELLKFSPTLGILKNGTSALH-AAVLSGNIKTVALLLEAGADPSLRNK 274
             +   +   +    + + G + LH AA    + K +  LL   A+P +R+K
Sbjct: 452 QCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDK 503



 Score = 92.4 bits (228), Expect = 4e-19
 Identities = 82/300 (27%), Positives = 130/300 (43%), Gaps = 42/300 (14%)

Query: 19  AARRGNLALLKLLLNSGRVD--VDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQR 76
           AA  G+   L+LL+ +      VD +D +G T LM++   GH DCV  L+ +GA+++ + 
Sbjct: 624 AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKD 683

Query: 77  ESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGA 136
           + G TAL   A  GH + V  L   GA    R   G T +  ++  GH+ V+  LL+  A
Sbjct: 684 KWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAA 743

Query: 137 NIHDQL----YDGATALFLAAQGGYLDVIRLLLAS------------------------- 167
           ++          G TAL  A   G+   + LLL                           
Sbjct: 744 SMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGA 803

Query: 168 --------GAK-VNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKA 218
                   GA  VN     G  PL  A+   H E ++++L   A  ++  + G T L+ A
Sbjct: 804 AEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMA 863

Query: 219 ANKGYNDVIKELLKFSPTLGILKNGT--SALHAAVLSGNIKTVALLLEAGADPSLRNKAN 276
           A  G  + ++ L+  +     L++ +  +ALH A   G+  +  L+LE   D +L N  N
Sbjct: 864 AENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATN 923



 Score = 84.7 bits (208), Expect = 9e-17
 Identities = 68/231 (29%), Positives = 105/231 (45%), Gaps = 1/231 (0%)

Query: 50  LMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRT 109
           L+ A + G  D VR L+ +  D+N Q     T L  AA  G  +++  L   GA    + 
Sbjct: 12  LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71

Query: 110 KDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGA 169
               T L  A      + V+ LLKH A+++ +  +  T L +AA    +     L+   +
Sbjct: 72  SKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLS 131

Query: 170 KVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKE 229
            VN   + G   L  A+  GH E+V+++L RGA+ +A       A+  AA  G+ +V+K 
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191

Query: 230 LLKFSPTLGIL-KNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
           L+     +    K   + LHAA  SG I  V  LL+ G D +  N     P
Sbjct: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP 242



 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 72/277 (25%), Positives = 123/277 (44%), Gaps = 15/277 (5%)

Query: 20  ARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESG 79
           A  G  +  + ++ SG V +DC D +G T L +AA  GH   +  L+  GAD   +   G
Sbjct: 314 ALHGRFSRSQTIIQSGAV-IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG 372

Query: 80  TTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIH 139
              L  AA  G +D  R L   G   +     G T L AA+  G+++ +  LL  GA+ +
Sbjct: 373 MFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN 432

Query: 140 DQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPL-WIASQMGHSEVVRVML 198
            +   G + L  AA       +  L+ SGA VN   + G  PL + A+     + +  +L
Sbjct: 433 KKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLL 492

Query: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILK-NGT------------S 245
              A+       G  A+  +A  G+   ++ +   +P   +++ +GT            S
Sbjct: 493 RNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATIS 552

Query: 246 ALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
            LH A   G+ + + +L+++  D  +RN +   P +L
Sbjct: 553 PLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDL 589



 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 52/213 (24%), Positives = 97/213 (45%), Gaps = 1/213 (0%)

Query: 82  ALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQ 141
           +L  A   G  D VR L        F+  +  T L AA+  G  +++E L+  GA ++ +
Sbjct: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70

Query: 142 LYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRG 201
                T L  A      + +++LL   A VN   ++   PL IA+     +    ++   
Sbjct: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130

Query: 202 ADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIKTVA 260
           ++ + +   G TAL  AA  G+ +++K LL     +    K    A+H A   G+I+ V 
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190

Query: 261 LLLEAGADPSLRNKANELPAELTKNERILRLLR 293
           LL+  GA+ + ++K +  P     +  ++ +++
Sbjct: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVK 223



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 65/256 (25%), Positives = 102/256 (39%), Gaps = 44/256 (17%)

Query: 19  AARRGNLALLKLLLNSGR---VDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQ 75
           +A  G++ +L  LL S      +    D+HG T L  A Y GH  CV EL+L+       
Sbjct: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCV-ELLLEQEVFQKT 784

Query: 76  RESGTTALFFAAQQGHNDVVRFLFG-FGASTEFRTKDGG-TALLAASQYGHMQVVETLLK 133
             +  + L  A    +      L    GAS    T   G T L AA+   H++ ++ LL 
Sbjct: 785 EGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLS 844

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAK----------------------- 170
           H A ++     G T L +AA+ G  + + +L++S +                        
Sbjct: 845 HNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHET 904

Query: 171 --------------VNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDG-TTAL 215
                         +N        PL +A++ G + VV+ +L +GA   A   +G T AL
Sbjct: 905 SALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPAL 964

Query: 216 LKAANKGYNDVIKELL 231
             A NK   D +  +L
Sbjct: 965 ACAPNKDVADCLALIL 980


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score =  120 bits (301), Expect = 1e-27
 Identities = 87/265 (32%), Positives = 130/265 (49%), Gaps = 15/265 (5%)

Query: 50  LMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRT 109
           L+VAAY G  + V +L+ +GA + + +  G T L  AA +GH  VV+ L   G   + + 
Sbjct: 14  LLVAAYKGQTENVVQLINKGARVAVTKH-GRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72

Query: 110 KDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGA 169
               TAL  A+  G+ +++  L+  G  +  Q  DG TAL  A+  G+    +LL+ +GA
Sbjct: 73  DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132

Query: 170 KVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKE 229
            V    + G   L +A Q  HS+  RV+LL G+  D   N G T L  AA   +  +I+ 
Sbjct: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192

Query: 230 LLK-FSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAE------- 281
           LL  F       + G +ALH A    + K   +LLEAGAD ++ N A + P E       
Sbjct: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252

Query: 282 ------LTKNERILRLLRSKEGPRK 300
                 LTK  ++LR  R +   +K
Sbjct: 253 PEVALLLTKAPQVLRFSRGRSLRKK 277


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  117 bits (292), Expect = 2e-26
 Identities = 86/281 (30%), Positives = 138/281 (49%), Gaps = 4/281 (1%)

Query: 20  ARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESG 79
           A + N   +  LL S + D +  ++ G T L VAAY GH+  V+ L  QGA+++ Q+ + 
Sbjct: 468 AAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL 527

Query: 80  TTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIH 139
            T L  A ++G    ++ L   GA  +   + G   L  A+  G   + + LL++GA++ 
Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLE 587

Query: 140 DQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLL 199
              + G T L LAA  G+L++I LL  S A +         PL +A++ G   VV  +L 
Sbjct: 588 LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQ 647

Query: 200 RGADRDAARNDGTTALLKAANKG-YNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKT 258
            GAD +AA   G T L  A  +  +  VI  L   +      K G +  H A L GN   
Sbjct: 648 CGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAI 707

Query: 259 VALLLEAGADPSLRNKANELPAEL---TKNERILRLLRSKE 296
           + +L+EAGA   +++  +  P +L   ++ + I+  L  KE
Sbjct: 708 LKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKE 748



 Score =  116 bits (291), Expect = 2e-26
 Identities = 86/278 (30%), Positives = 139/278 (50%), Gaps = 10/278 (3%)

Query: 8   KETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVL 67
           K TPL     +   +G++  ++LLL +  VDVDC+ + G T L++AA     D    L+ 
Sbjct: 362 KVTPL----HFLVAQGSVEQVRLLL-AHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA 416

Query: 68  QGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQV 127
            GAD N   E G   L FAAQ G +   R L   GA  + + ++G T L  A+Q     V
Sbjct: 417 HGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENV 476

Query: 128 VETLLKHGA--NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIA 185
              L+   A  N+H+   +G T L +AA  G++ +++LL + GA+++  +++   PL +A
Sbjct: 477 ARLLVSRQADPNLHEA--EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLA 534

Query: 186 SQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGT 244
            + G    ++ +L  GA  DA    G   L  AA +G   + K LL++  +L +    G 
Sbjct: 535 VERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW 594

Query: 245 SALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
           + LH A   G+++ + LL E+ A+       N  P  L
Sbjct: 595 TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHL 632



 Score =  104 bits (259), Expect = 1e-22
 Identities = 78/253 (30%), Positives = 112/253 (44%), Gaps = 1/253 (0%)

Query: 41  CRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFG 100
           C   +  T L      G ++ VR L+    D++ Q  SG T L  AAQ    D+   L  
Sbjct: 357 CIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA 416

Query: 101 FGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDV 160
            GA      +DG   L  A+Q G       LL HGA +  Q  +G T L LAAQ  + +V
Sbjct: 417 HGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENV 476

Query: 161 IRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAAN 220
            RLL++  A  N    +G  PL +A+  GH  +V+++  +GA+ DA + +  T L  A  
Sbjct: 477 ARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVE 536

Query: 221 KGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
           +G    I+ LLK       L ++G   LH A   G      +LL  GA   L       P
Sbjct: 537 RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTP 596

Query: 280 AELTKNERILRLL 292
             L   +  L ++
Sbjct: 597 LHLAAYKGHLEII 609



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 45/153 (29%), Positives = 62/153 (40%), Gaps = 13/153 (8%)

Query: 155 GGYLDVIRLLLASGAKVNQPR-------QDGTAPLWIASQMGHSEVVRVMLLRGADRDAA 207
           G YL   R L  S  K   PR       ++   PL      G  E VR++L    D D  
Sbjct: 334 GNYLK--RALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQ 391

Query: 208 RNDGTTALLKAANKGYNDVIKELLKFSPTLG-ILKNGTSALHAAVLSGNIKTVALLLEAG 266
              G T LL AA     D+   LL        + ++G + LH A  +G+  T  LLL+ G
Sbjct: 392 TASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHG 451

Query: 267 ADPSLRNKANELPAELTKN---ERILRLLRSKE 296
           A    + +    P  L      E + RLL S++
Sbjct: 452 ACVDAQEREGWTPLHLAAQNNFENVARLLVSRQ 484


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score =  115 bits (288), Expect = 5e-26
 Identities = 93/274 (33%), Positives = 139/274 (50%), Gaps = 16/274 (5%)

Query: 23   GNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTA 82
            G+  ++ LLL  G   +D    +G T L  AA AGH+  V  L  +G  ++   + G  A
Sbjct: 938  GHEEVVTLLLEFGAC-LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCA 996

Query: 83   LFFAAQQGHNDVVRFLFGFGAS-------TEFRTKDGGTALLAASQYGHMQVVETLL--- 132
            L  +A +GH D++++L     S       T  ++     AL AA+  GH  VV+ LL   
Sbjct: 997  LVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGME 1056

Query: 133  -KHGANIH--DQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMG 189
             +H   ++  D L+ G TAL  AA  G L+V  LLL  GA V++  + G  PL+ A++ G
Sbjct: 1057 KEHEVEVNGTDTLW-GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQG 1115

Query: 190  HSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALH 248
            H ++VR++L RG D + +   G T L+ AA +G+   ++ LL     L  L K G SAL 
Sbjct: 1116 HWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALS 1175

Query: 249  AAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
             A L G+   V  L+E GA     +K    P +L
Sbjct: 1176 WACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1209



 Score = 96.7 bits (239), Expect = 2e-20
 Identities = 72/238 (30%), Positives = 115/238 (48%), Gaps = 4/238 (1%)

Query: 5    SFKKETPLANAAFWAARRGNLALLKLLLNSGR---VDVDCRDS-HGTTLLMVAAYAGHID 60
            + +K   L  A   AA  G+ ++++ LL   +   V+V+  D+  G T L  AA  G ++
Sbjct: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085

Query: 61   CVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAAS 120
                L+  GA ++     G   LF AA+QGH  +VR L   G       K G T L+ A+
Sbjct: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1145

Query: 121  QYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTA 180
              GH+  VE LL  GA +     +G +AL  A   G+  V++ L+  GA ++Q  ++G  
Sbjct: 1146 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1205

Query: 181  PLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLG 238
            PL +A+  G +E V  ++ +GA  +   + G   L +A       V+  LL+    LG
Sbjct: 1206 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLG 1263



 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 51/165 (30%), Positives = 78/165 (47%), Gaps = 34/165 (20%)

Query: 17   FWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQR 76
            F AAR+G+  +++LLL  G  DV+  D  G T LMVAA  GH+  V  L+ +GA ++   
Sbjct: 1109 FCAARQGHWQIVRLLLERG-CDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLD 1167

Query: 77   ESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQ---------- 126
            + G +AL +A  +GH  VV++L   GA+ +   K+G T L  A+ YG  +          
Sbjct: 1168 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGA 1227

Query: 127  -----------------------VVETLLKHGANIHDQLYDGATA 148
                                   VV  LL+ GA + +  +  AT+
Sbjct: 1228 VIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATS 1272


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score =  115 bits (288), Expect = 5e-26
 Identities = 93/274 (33%), Positives = 139/274 (50%), Gaps = 16/274 (5%)

Query: 23   GNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTA 82
            G+  ++ LLL  G   +D    +G T L  AA AGH+  V  L  +G  ++   + G  A
Sbjct: 946  GHEEVVTLLLEFGAC-LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCA 1004

Query: 83   LFFAAQQGHNDVVRFLFGFGAS-------TEFRTKDGGTALLAASQYGHMQVVETLL--- 132
            L  +A +GH D++++L     S       T  ++     AL AA+  GH  VV+ LL   
Sbjct: 1005 LVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGME 1064

Query: 133  -KHGANIH--DQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMG 189
             +H   ++  D L+ G TAL  AA  G L+V  LLL  GA V++  + G  PL+ A++ G
Sbjct: 1065 KEHEVEVNGTDTLW-GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQG 1123

Query: 190  HSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALH 248
            H ++VR++L RG D + +   G T L+ AA +G+   ++ LL     L  L K G SAL 
Sbjct: 1124 HWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALS 1183

Query: 249  AAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
             A L G+   V  L+E GA     +K    P +L
Sbjct: 1184 WACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1217



 Score = 96.7 bits (239), Expect = 2e-20
 Identities = 72/238 (30%), Positives = 115/238 (48%), Gaps = 4/238 (1%)

Query: 5    SFKKETPLANAAFWAARRGNLALLKLLLNSGR---VDVDCRDS-HGTTLLMVAAYAGHID 60
            + +K   L  A   AA  G+ ++++ LL   +   V+V+  D+  G T L  AA  G ++
Sbjct: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093

Query: 61   CVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAAS 120
                L+  GA ++     G   LF AA+QGH  +VR L   G       K G T L+ A+
Sbjct: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1153

Query: 121  QYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTA 180
              GH+  VE LL  GA +     +G +AL  A   G+  V++ L+  GA ++Q  ++G  
Sbjct: 1154 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1213

Query: 181  PLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLG 238
            PL +A+  G +E V  ++ +GA  +   + G   L +A       V+  LL+    LG
Sbjct: 1214 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLG 1271



 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 51/165 (30%), Positives = 78/165 (47%), Gaps = 34/165 (20%)

Query: 17   FWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQR 76
            F AAR+G+  +++LLL  G  DV+  D  G T LMVAA  GH+  V  L+ +GA ++   
Sbjct: 1117 FCAARQGHWQIVRLLLERG-CDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLD 1175

Query: 77   ESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQ---------- 126
            + G +AL +A  +GH  VV++L   GA+ +   K+G T L  A+ YG  +          
Sbjct: 1176 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGA 1235

Query: 127  -----------------------VVETLLKHGANIHDQLYDGATA 148
                                   VV  LL+ GA + +  +  AT+
Sbjct: 1236 VIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATS 1280


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score =  114 bits (284), Expect = 1e-25
 Identities = 91/279 (32%), Positives = 138/279 (49%), Gaps = 21/279 (7%)

Query: 23   GNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTA 82
            G   ++ LLL  G  +VD     G T L  AA AG++  V  L  + A ++   ++G  A
Sbjct: 896  GYTEMVALLLEFG-ANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCA 954

Query: 83   LFFAAQQGHNDVVRFLF-------GFGASTEFRTKDGGTALLAASQYGHMQVVETLL--- 132
            L  AA +GH +VV+FL        G       ++     AL+AA+  G+ ++V  LL   
Sbjct: 955  LVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLP 1014

Query: 133  --------KHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWI 184
                    +   N  D L+ G TAL  AA  G L+V RLLL  GA V QP + G  PL+ 
Sbjct: 1015 EKDEEEVERAQINSFDSLW-GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFS 1073

Query: 185  ASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNG 243
              + GH ++V ++L  GAD + A   G T L+ AA++G+   +  LL    ++ ++ K G
Sbjct: 1074 TVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEG 1133

Query: 244  TSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
             +AL  A L G++  V  L++ GA     +K    P +L
Sbjct: 1134 LTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDL 1172



 Score = 99.4 bits (246), Expect = 4e-21
 Identities = 76/242 (31%), Positives = 111/242 (45%), Gaps = 9/242 (3%)

Query: 6    FKKETPLANAAFWAARRGNLALLKLLLNSG--------RVDVDCRDS-HGTTLLMVAAYA 56
            FKK   +  A   AA  G   ++  LL+          R  ++  DS  G T L  AA  
Sbjct: 985  FKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGR 1044

Query: 57   GHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTAL 116
            G ++  R L+ QGA +      G   LF   +QGH  +V  L   GA      K G T L
Sbjct: 1045 GKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPL 1104

Query: 117  LAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQ 176
            + A+  GH+  V+ LL  GA+I     +G TAL  A   G+L V+R L+ +GA  +   +
Sbjct: 1105 MMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADK 1164

Query: 177  DGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPT 236
            +G  PL +A+  G +EVV+ ++  GA  +     G   L +A       V+  LLK    
Sbjct: 1165 NGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAK 1224

Query: 237  LG 238
            +G
Sbjct: 1225 IG 1226



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 70/252 (27%), Positives = 114/252 (45%), Gaps = 20/252 (7%)

Query: 55   YAGHIDCVRELVLQGADINLQRESGTTALFFAAQQ--GHNDVVRFLFGFGASTEFRTKDG 112
            Y  +I   R L+L GA+IN + E    A     Q   G+ ++V  L  FGA+ +  ++ G
Sbjct: 859  YTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESG 918

Query: 113  GTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVN 172
             T L  A+  G++ +V  L K  A +     +G  AL  AA  G+L+V++ L+     + 
Sbjct: 919  LTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMA 978

Query: 173  QPRQDG-------TAPLWIASQMGHSEVVRVML-LRGADRDAARND---------GTTAL 215
              +Q            L  A+ MG++E+V  +L L   D +              G TAL
Sbjct: 979  GQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETAL 1038

Query: 216  LKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIKTVALLLEAGADPSLRNK 274
              AA +G  +V + LL+    +    + G   L + V  G+ + V LLL  GAD ++ +K
Sbjct: 1039 TAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADK 1098

Query: 275  ANELPAELTKNE 286
                P  +  +E
Sbjct: 1099 QGRTPLMMAASE 1110



 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 57/165 (34%), Positives = 76/165 (46%), Gaps = 34/165 (20%)

Query: 17   FWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQR 76
            F   R+G+  ++ LLL  G  DV+  D  G T LM+AA  GH+  V  L+ QGA I L  
Sbjct: 1072 FSTVRQGHWQIVDLLLTHG-ADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMD 1130

Query: 77   ESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVE------- 129
            + G TAL +A  +GH  VVR L   GA+T+   K+G T L  A+ YG  +VV+       
Sbjct: 1131 KEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGA 1190

Query: 130  --------------------------TLLKHGANIHDQLYDGATA 148
                                      TLLK GA I    +  AT+
Sbjct: 1191 MIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATS 1235



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 68/240 (28%), Positives = 106/240 (44%), Gaps = 22/240 (9%)

Query: 62   VRELVLQGADINLQRESGTTALFFAAQ--QGHNDVVRFLFGFGASTEFRTK--DGGTALL 117
            V   +LQG  I+   E  + AL         +  V R L   GA+  +RT+  +    L 
Sbjct: 831  VSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILC 890

Query: 118  AASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQD 177
              S  G+ ++V  LL+ GAN+      G T L  AA  GYL ++ LL    AKV+   ++
Sbjct: 891  VQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKN 950

Query: 178  GTAPLWIASQMGHSEVVRVML-----LRGADRDAARNDGT--TALLKAANKGYNDVIKEL 230
            G   L  A+  GH EVV+ ++     + G  +   +       AL+ AA+ GY +++  L
Sbjct: 951  GQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYL 1010

Query: 231  LKF---------SPTLGILKN--GTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
            L              +    +  G +AL AA   G ++   LLLE GA  +  N+   +P
Sbjct: 1011 LDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVP 1070


>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
           a [Homo sapiens]
          Length = 518

 Score =  113 bits (283), Expect = 2e-25
 Identities = 89/291 (30%), Positives = 138/291 (47%), Gaps = 41/291 (14%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGAD---INLQ 75
           AAR GN+ +L+ LL  GR  VD  D+ G   +  AAY   ++C++ L+   +    I ++
Sbjct: 17  AAREGNVKVLRKLLKKGR-SVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75

Query: 76  RESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHG 135
              G  AL  AA QGH  +V+ L   GA     T +  T L  A + G + V+  LL+HG
Sbjct: 76  TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135

Query: 136 ANIH--------DQLYD--------------------------GATALFLAAQGGYLDVI 161
           AN++        + L+                           G T LF+AAQ G L+ +
Sbjct: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195

Query: 162 RLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTAL--LKAA 219
            +L++SGA VN    D   PL+IA+Q GH++ V ++L  GAD D   N+ +  L    AA
Sbjct: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255

Query: 220 NKGYNDVIKELLKF-SPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADP 269
             G+  ++  L+   +       N  S +++AV  G+   + +LL  G  P
Sbjct: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSP 306



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 64/224 (28%), Positives = 108/224 (48%), Gaps = 37/224 (16%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA +G+  ++++LL +G  D +      TT L +A   G ID +R L+  GA++N     
Sbjct: 86  AASQGHWKIVQILLEAG-ADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSM 144

Query: 79  -GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
            G  +L  A+ Q + ++++ L   GA+ E +   G T L  A+QYG ++ +  L+  GAN
Sbjct: 145 CGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGAN 204

Query: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGT--APLWIASQMGHSEVV- 194
           ++ Q  D AT LF+AAQ G+   + LLL+SGA  +    + +   P+  A+QMGH++++ 
Sbjct: 205 VNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILD 264

Query: 195 --------------------------------RVMLLRGADRDA 206
                                            ++L  G   DA
Sbjct: 265 LLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 308



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 35/121 (28%), Positives = 58/121 (47%), Gaps = 4/121 (3%)

Query: 177 DGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPT 236
           D  + + +A++ G+ +V+R +L +G   D A N G   + +AA     + ++ L+    +
Sbjct: 9   DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68

Query: 237 LGILK----NGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLL 292
              +K     G  ALH A   G+ K V +LLEAGADP+        P  L      + +L
Sbjct: 69  ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128

Query: 293 R 293
           R
Sbjct: 129 R 129



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 42/163 (25%), Positives = 67/163 (41%), Gaps = 38/163 (23%)

Query: 144 DGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAP---------------------- 181
           D  + + LAA+ G + V+R LL  G  V+     G  P                      
Sbjct: 9   DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68

Query: 182 --------------LWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVI 227
                         L +A+  GH ++V+++L  GAD +A   + TT L  A   G  DV+
Sbjct: 69  ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128

Query: 228 KELLKFSPTLGILKN--GTSALHAAVLSGNIKTVALLLEAGAD 268
           + LL+    +    +  G ++LH A    N + + LLL  GA+
Sbjct: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGAN 171


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  113 bits (282), Expect = 2e-25
 Identities = 84/282 (29%), Positives = 135/282 (47%), Gaps = 21/282 (7%)

Query: 18  WAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
           WAA  G+L +LKLL+  G  D+ C+D  G  LL  AA +G I+ V+ L+  GA+I+    
Sbjct: 179 WAAFLGHLEVLKLLVARG-ADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNA 237

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTAL-LAASQYGHMQVVETLLKHGA 136
            G TAL  A   G + V   L   GA+       G T L +AA        +E L+ +GA
Sbjct: 238 FGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGA 297

Query: 137 NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRV 196
           +++ Q  +G + L +AA  G     ++L+ +G++++   + G  PL +A++ GH  ++  
Sbjct: 298 DVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIST 357

Query: 197 MLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKN-------------- 242
           ++  GAD           L  A   G++D  ++LL       I+ +              
Sbjct: 358 LMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDIN 417

Query: 243 -----GTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
                G + LHAA   GN++ + LLL +GAD   R+K    P
Sbjct: 418 TPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTP 459



 Score = 95.1 bits (235), Expect = 7e-20
 Identities = 82/272 (30%), Positives = 121/272 (44%), Gaps = 7/272 (2%)

Query: 10  TPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQG 69
           TPL  AA   A R    L  LL +S   DV+ RD    T L VAA      C   L    
Sbjct: 76  TPLHRAA---ASRNEKVLGLLLAHSA--DVNARDKLWQTPLHVAAANRATKCAEALAPLL 130

Query: 70  ADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVE 129
           + +N+   SG +AL  A   GH + V  L   GAS     K     L  A+  GH++V++
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190

Query: 130 TLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMG 189
            L+  GA++  +   G   L  AA  G ++V++ LL  GA++++P   G   L IA  +G
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250

Query: 190 HSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELL--KFSPTLGILKNGTSAL 247
              V   ++  GA+ +   + G T L  AA      +  ELL    +      K G S L
Sbjct: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310

Query: 248 HAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
           H A + G      +L++ G++    +K    P
Sbjct: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTP 342



 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 82/276 (29%), Positives = 132/276 (47%), Gaps = 7/276 (2%)

Query: 9   ETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQ 68
           +TPL  AA   A +   AL  LL +     ++  D  G + L  A ++GH++ V  L+ +
Sbjct: 108 QTPLHVAAANRATKCAEALAPLLSS-----LNVADRSGRSALHHAVHSGHLETVNLLLNK 162

Query: 69  GADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVV 128
           GA +N+  +     L +AA  GH +V++ L   GA    + + G   L  A+  G ++VV
Sbjct: 163 GASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVV 222

Query: 129 ETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQM 188
           + LL+ GA I +    G TAL +A   G   V   L+ +GA VNQP   G  PL +A+  
Sbjct: 223 KYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVS 282

Query: 189 GHSEVVRVMLLR-GADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSA 246
            +  +   +L+  GAD +    +G + L  AA  G     + L++    +    K G + 
Sbjct: 283 TNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTP 342

Query: 247 LHAAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
           LH A   G+   ++ L+  GAD + R   +  P  L
Sbjct: 343 LHVAARYGHELLISTLMTNGADTARRGIHDMFPLHL 378



 Score = 92.0 bits (227), Expect = 6e-19
 Identities = 79/255 (30%), Positives = 112/255 (43%), Gaps = 9/255 (3%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL-QRE 77
           AA  G+   LK L  +  V++D RD  G T L +A   G  +CV  L   GA   + +R+
Sbjct: 592 AAYNGHCEALKTLAET-LVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERK 650

Query: 78  SGTTALFFAAQQGHNDVVRFLFGFGAS---TEFRTKDGGTALLAASQYGHMQVVETLLKH 134
              T L  AA  GH D +  L   G     T+     G T L+ A   GH+  V  LL+ 
Sbjct: 651 RKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710

Query: 135 GANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVV 194
           G+        G TAL   A  G  D +  LL   A V      G  P+ +AS  GH+ V+
Sbjct: 711 GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVL 770

Query: 195 RVMLLRGADRD----AARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAA 250
           R +L      D         G + +  A+  G+ D ++ LL+ SP   +  N  + LH A
Sbjct: 771 RTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCA 830

Query: 251 VLSGNIKTVALLLEA 265
           V++    T  +LL A
Sbjct: 831 VINNQDSTTEMLLGA 845



 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 80/279 (28%), Positives = 122/279 (43%), Gaps = 10/279 (3%)

Query: 4   MSFKKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVR 63
           +S   + PL  A F        +LL     S + +++  D    T L  AAY G +  ++
Sbjct: 4   LSITDQPPLVQAIFSRDVEEVRSLL-----SQKENINVLDQERRTPLHAAAYVGDVPILQ 58

Query: 64  ELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYG 123
            L++ GA++N +     T L  AA   +  V+  L    A    R K   T L  A+   
Sbjct: 59  LLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANR 118

Query: 124 HMQVVETL--LKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAP 181
             +  E L  L    N+ D+   G +AL  A   G+L+ + LLL  GA +N   +    P
Sbjct: 119 ATKCAEALAPLLSSLNVADR--SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP 176

Query: 182 LWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILK 241
           L  A+ +GH EV+++++ RGAD       G   L  AA  G  +V+K LL+    +    
Sbjct: 177 LHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPN 236

Query: 242 N-GTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
             G +ALH A   G       L+ AGA+ +  N     P
Sbjct: 237 AFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTP 275



 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 96/313 (30%), Positives = 136/313 (43%), Gaps = 48/313 (15%)

Query: 7   KKETPLANAAFWAARRGNLALLKLLLNSG-RVDV-DCRDSHGTTLLMVAAYAGHIDCVRE 64
           +K TPL  AA      G+   L LL++SG R D+ D  D++G T LM+A   GH+DCV  
Sbjct: 651 RKWTPLHAAA----ASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHL 706

Query: 65  LVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGH 124
           L+ +G+  +     G TAL   A  G  D +  L    A    R   G T +  AS  GH
Sbjct: 707 LLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGH 766

Query: 125 MQVVETLLKHGANIHDQL-----YDGATALFLAAQGGYLDVIRLLL-------------- 165
             V+ TLL+  A   D L     Y G + +  A+  G+ D + LLL              
Sbjct: 767 TAVLRTLLQ-AALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFT 825

Query: 166 -------------------ASGAK-VNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRD 205
                              A GAK VN     G  PL  A+   +   +R++L   A+ +
Sbjct: 826 PLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN 885

Query: 206 AARNDGTTALLKAANKGYNDVIKELL-KFSPTLGIL-KNGTSALHAAVLSGNIKTVALLL 263
           A  + G TAL+ AA  G    ++ LL +    L +L +N  +ALH A   G+ K   ++L
Sbjct: 886 ATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMIL 945

Query: 264 EAGADPSLRNKAN 276
               D  L N  N
Sbjct: 946 AETQDLGLINATN 958



 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 78/284 (27%), Positives = 116/284 (40%), Gaps = 51/284 (17%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAG--------------------- 57
           AA  G + ++K LL  G  ++D  ++ G T L +A Y G                     
Sbjct: 213 AAASGQIEVVKYLLRMG-AEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDK 271

Query: 58  -----HID--------CVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGAS 104
                H+         C+  LV  GAD+N Q + G + L  AA  G     + L   G+ 
Sbjct: 272 GFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSE 331

Query: 105 TEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLL 164
            +   K G T L  A++YGH  ++ TL+ +GA+   +       L LA   G+ D  R L
Sbjct: 332 IDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKL 391

Query: 165 LASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYN 224
           L+SG   +           I S + +  V    L  G D +   N G T L  AA+ G  
Sbjct: 392 LSSGQLYS-----------IVSSLSNEHV----LSAGFDINTPDNLGRTCLHAAASGGNV 436

Query: 225 DVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIKTVALLLEAGA 267
           + +  LL     L    K G + LH A  +G+ +    L+ AGA
Sbjct: 437 ECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480



 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 64/229 (27%), Positives = 107/229 (46%), Gaps = 7/229 (3%)

Query: 61  CVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFL--FGFGASTEFRTKDGGTALLA 118
           C+  L+  GAD +L+   G TA+ +AA  G+   +  L    F    +  +    + L  
Sbjct: 532 CLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHL 591

Query: 119 ASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAK-VNQPRQD 177
           A+  GH + ++TL +   N+  + + G TALFLA + G  + + +L A GA  + + R+ 
Sbjct: 592 AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651

Query: 178 GTAPLWIASQMGHSEVVRVMLLRG--AD-RDAARNDGTTALLKAANKGYNDVIKELLKFS 234
              PL  A+  GH++ + +++  G  AD  D     G T L+ A   G+ D +  LL+  
Sbjct: 652 KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711

Query: 235 PTLGILK-NGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
            T       G +ALH   ++G    +A LL+  A    R+     P  L
Sbjct: 712 STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHL 760



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 48/150 (32%), Positives = 70/150 (46%), Gaps = 10/150 (6%)

Query: 39  VDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFL 98
           V+ RD+ G T L  AA+A ++  +R L+   A++N    +G TAL  AA+ G    V FL
Sbjct: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910

Query: 99  FGFG-ASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGAT------ALFL 151
              G A      ++  TAL  A   GH +    +L   A   D     AT       L +
Sbjct: 911 LYRGKADLTVLDENKNTALHLACSKGHEKCALMIL---AETQDLGLINATNSALQMPLHI 967

Query: 152 AAQGGYLDVIRLLLASGAKVNQPRQDGTAP 181
           AA+ G   V++ LL+ GA V    ++G  P
Sbjct: 968 AARNGLASVVQALLSHGATVLAVDEEGHTP 997



 Score = 35.0 bits (79), Expect = 0.081
 Identities = 31/130 (23%), Positives = 54/130 (41%), Gaps = 32/130 (24%)

Query: 158 LDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLK 217
           ++ +R LL+    +N   Q+   PL  A+ +G   +++++L+ GA+ +A           
Sbjct: 21  VEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNA----------- 69

Query: 218 AANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANE 277
                     K+ L  +P           LH A  S N K + LLL   AD + R+K  +
Sbjct: 70  ----------KDTLWLTP-----------LHRAAASRNEKVLGLLLAHSADVNARDKLWQ 108

Query: 278 LPAELTKNER 287
            P  +    R
Sbjct: 109 TPLHVAAANR 118


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  110 bits (275), Expect = 2e-24
 Identities = 78/239 (32%), Positives = 119/239 (49%), Gaps = 6/239 (2%)

Query: 31  LLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQG 90
           LL + ++ V+ +D    T L  AA  G     R L+ + A +N     G T +  A Q G
Sbjct: 489 LLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHG 548

Query: 91  HNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKH-GANIHDQLYDGATAL 149
             ++VR L   G     + KD    L  A+  GH+ +V+ L K  G +++ Q  DG T L
Sbjct: 549 QENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPL 608

Query: 150 FLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARN 209
            LAAQ G+  V R+L+   + VN        PL +A++ GH+   R++L RGA ++A  +
Sbjct: 609 HLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTS 668

Query: 210 DGTTALLKAANKGYNDVIKELLKFSPTLGILKNG---TSALHAAVLSGNIKTVALLLEA 265
           DG TAL  AA  G+   +K L++      +L  G    +ALH A   G+ + V  L+ A
Sbjct: 669 DGYTALHLAARNGHLATVKLLVE--EKADVLARGPLNQTALHLAAAHGHSEVVEELVSA 725



 Score =  108 bits (271), Expect = 4e-24
 Identities = 85/260 (32%), Positives = 131/260 (50%), Gaps = 2/260 (0%)

Query: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
           A  +AA+ G+ +  +LLL      V+  D  G T + VA   G  + VR L+ +G D++L
Sbjct: 507 ALHFAAQNGDESSTRLLLEKN-ASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSL 565

Query: 75  QRESGTTALFFAAQQGHNDVVRFLFGF-GASTEFRTKDGGTALLAASQYGHMQVVETLLK 133
           Q +     L +AA QGH  +V+ L    G S   +T DG T L  A+Q GH +V   L+ 
Sbjct: 566 QGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILID 625

Query: 134 HGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
             ++++       T L +AA+ G+    RLLL  GA       DG   L +A++ GH   
Sbjct: 626 LCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLAT 685

Query: 194 VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLS 253
           V++++   AD  A      TAL  AA  G+++V++EL+         + G SALH A   
Sbjct: 686 VKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQG 745

Query: 254 GNIKTVALLLEAGADPSLRN 273
            + +TV  LL  GA  +L++
Sbjct: 746 RHAQTVETLLRHGAHINLQS 765



 Score =  104 bits (259), Expect = 1e-22
 Identities = 71/232 (30%), Positives = 114/232 (49%), Gaps = 2/232 (0%)

Query: 38  DVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRF 97
           DVD     G +LL +A  AG  +C + L+L  A+ NL    G+T L  A ++    VV  
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489

Query: 98  LFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGY 157
           L     S   + +D  TAL  A+Q G       LL+  A++++  ++G T + +A Q G 
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549

Query: 158 LDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLR-GADRDAARNDGTTALL 216
            +++R+LL  G  V+   +D   PL  A+  GH  +V+++  + G   +A   DG T L 
Sbjct: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLH 609

Query: 217 KAANKGYNDVIKELLKFSPTLGILK-NGTSALHAAVLSGNIKTVALLLEAGA 267
            AA +G+  V + L+     + +      + LH A  +G+  T  LLL  GA
Sbjct: 610 LAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA 661



 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 63/217 (29%), Positives = 104/217 (47%), Gaps = 4/217 (1%)

Query: 66  VLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHM 125
           +LQ  D++L  +SG + L  A + G  +  ++L    A+     + G T L  A +    
Sbjct: 425 ILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVR 484

Query: 126 QVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIA 185
            VVE LL    +++ +  D  TAL  AAQ G     RLLL   A VN+   +G  P+ +A
Sbjct: 485 GVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVA 544

Query: 186 SQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGI---LKN 242
            Q G   +VR++L RG D      D    L  AA +G+  ++K L K  P + +     +
Sbjct: 545 CQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK-QPGVSVNAQTLD 603

Query: 243 GTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
           G + LH A   G+ +   +L++  +D ++ +   + P
Sbjct: 604 GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTP 640



 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 55/149 (36%), Positives = 75/149 (50%), Gaps = 10/149 (6%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA  G+ +  +LLL+ G    +   S G T L +AA  GH+  V+ LV + AD+  +   
Sbjct: 644 AAETGHTSTARLLLHRG-AGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPL 702

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
             TAL  AA  GH++VV  L        F  + G +AL  A+Q  H Q VETLL+HGA+I
Sbjct: 703 NQTALHLAAAHGHSEVVEELVSADVIDLF-DEQGLSALHLAAQGRHAQTVETLLRHGAHI 761

Query: 139 HDQLYDGATALFLAAQGGYLDVIRLLLAS 167
           + Q         L  QGG+     LL  S
Sbjct: 762 NLQ--------SLKFQGGHGPAATLLRRS 782



 Score = 32.0 bits (71), Expect = 0.69
 Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 6/92 (6%)

Query: 203 DRDAARND-GTT-----ALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNI 256
           +R+ + +D GTT      L+ A   G    + ++L+       L +G S LH AV +G  
Sbjct: 392 EREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQE 451

Query: 257 KTVALLLEAGADPSLRNKANELPAELTKNERI 288
           +    LL   A+P+L N+    P  +    R+
Sbjct: 452 ECAKWLLLNNANPNLSNRRGSTPLHMAVERRV 483


>gi|148596917 fibronectin type III and ankyrin repeat domains 1
           [Homo sapiens]
          Length = 345

 Score =  109 bits (272), Expect = 3e-24
 Identities = 71/191 (37%), Positives = 99/191 (51%), Gaps = 2/191 (1%)

Query: 27  LLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFA 86
           LL  +L  GRV VD  +  G T LMVAA  G+   V+ LV  G D+NL+  SG  +L  A
Sbjct: 125 LLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLA 184

Query: 87  AQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIH--DQLYD 144
              GH DVV++L   GAS + R   G TAL  A+  GH  V+E ++K G  +   D    
Sbjct: 185 CYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244

Query: 145 GATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADR 204
               + ++A  G   V  LL+ +GA VN   ++G  PL +A    H E+V+++L +GAD 
Sbjct: 245 WTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADA 304

Query: 205 DAARNDGTTAL 215
                 G   L
Sbjct: 305 SVKNEFGKGVL 315



 Score = 85.5 bits (210), Expect = 5e-17
 Identities = 57/181 (31%), Positives = 95/181 (52%), Gaps = 3/181 (1%)

Query: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
           AA++G   L+K+L+++G  DV+ ++  G   LM+A YAGH+D V+ L   GA    +   
Sbjct: 151 AAQKGYTRLVKILVSNG-TDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLG 209

Query: 79  GTTALFFAAQQGHNDVVRFLFGFGASTE-FRTKDGGTALLAASQY-GHMQVVETLLKHGA 136
           G TAL +AA  GH  V+ ++   G   +   T  G T L+  S   G+ +V   L+  GA
Sbjct: 210 GCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGA 269

Query: 137 NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRV 196
           N++ +  +G T L +A    + ++++LLL  GA  +   + G   L +A       VV +
Sbjct: 270 NVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSL 329

Query: 197 M 197
           +
Sbjct: 330 L 330



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 64/217 (29%), Positives = 110/217 (50%), Gaps = 9/217 (4%)

Query: 94  VVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAA 153
           +VR L G     +   K G TAL+ A+Q G+ ++V+ L+ +G +++ +   G  +L LA 
Sbjct: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185

Query: 154 QGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAA-RNDGT 212
             G+LDV++ L   GA        G   L  A+  GH  V+  M+  G + D      G 
Sbjct: 186 YAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGW 245

Query: 213 TALLK-AANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIKTVALLLEAGADPS 270
           T L++ +A  G   V   L+     + +  +NG + L  AVL+ + + V LLL+ GAD S
Sbjct: 246 TPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADAS 305

Query: 271 LRNKANELPAELTK---NERILRLL---RSKEGPRKS 301
           ++N+  +   E+ +    + ++ LL   + K+ P+KS
Sbjct: 306 VKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPKKS 342


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.134    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,797,261
Number of Sequences: 37866
Number of extensions: 371515
Number of successful extensions: 5458
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 347
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 817
Number of HSP's gapped (non-prelim): 1974
length of query: 301
length of database: 18,247,518
effective HSP length: 102
effective length of query: 199
effective length of database: 14,385,186
effective search space: 2862652014
effective search space used: 2862652014
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.