Search of human proteins with 68989256

Search of human proteins with 68989256

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|68989256 ras inhibitor RIN1 [Homo sapiens]
         (783 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|68989256 ras inhibitor RIN1 [Homo sapiens]                        1558   0.0  
gi|18466802 Ras and Rab interactor 2 [Homo sapiens]                   236   8e-62
gi|40353729 Ras and Rab interactor 3 [Homo sapiens]                   164   3e-40
gi|38348206 Ras and Rab interactor-like [Homo sapiens]                 87   6e-17
gi|108860690 chromosome 16 open reading frame 7 [Homo sapiens]         54   7e-07
gi|7657496 RAB guanine nucleotide exchange factor (GEF) 1 [Homo ...    53   1e-06
gi|65288071 tensin 3 [Homo sapiens]                                    48   3e-05
gi|7662302 TBK1 binding protein 1 [Homo sapiens]                       47   7e-05
gi|149773456 hypothetical protein LOC643314 [Homo sapiens]             45   2e-04
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat...    44   8e-04
gi|157738639 tensin 4 [Homo sapiens]                                   43   0.001
gi|119829187 alpha 1 type XVII collagen [Homo sapiens]                 42   0.002
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    42   0.002
gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens]           41   0.004
gi|208022661 hypothetical protein LOC57701 [Homo sapiens]              41   0.005
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              41   0.005
gi|89941470 ankyrin repeat domain 34 [Homo sapiens]                    41   0.005
gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]      40   0.006
gi|163965366 nascent polypeptide-associated complex alpha subuni...    40   0.006
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    40   0.008
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex...    40   0.008
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int...    40   0.011
gi|150378503 leiomodin 2 (cardiac) [Homo sapiens]                      40   0.011
gi|170763515 DMRT-like family A1 [Homo sapiens]                        40   0.011
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]                     39   0.014
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]                     39   0.014
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom...    39   0.014
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom...    39   0.014
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap...    39   0.014
gi|149944516 tet oncogene family member 3 [Homo sapiens]               39   0.014

>gi|68989256 ras inhibitor RIN1 [Homo sapiens]
          Length = 783

 Score = 1558 bits (4035), Expect = 0.0
 Identities = 783/783 (100%), Positives = 783/783 (100%)

Query: 1   MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE 60
           MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE
Sbjct: 1   MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE 60

Query: 61  RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH 120
           RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH
Sbjct: 61  RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH 120

Query: 121 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL 180
           YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL
Sbjct: 121 YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL 180

Query: 181 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK 240
           GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK
Sbjct: 181 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK 240

Query: 241 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG 300
           FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG
Sbjct: 241 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG 300

Query: 301 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP 360
           SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP
Sbjct: 301 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP 360

Query: 361 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE 420
           ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE
Sbjct: 361 ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE 420

Query: 421 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF 480
           KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF
Sbjct: 421 KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF 480

Query: 481 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL 540
           GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL
Sbjct: 481 GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL 540

Query: 541 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL 600
           PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL
Sbjct: 541 PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL 600

Query: 601 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA 660
           SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA
Sbjct: 601 SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA 660

Query: 661 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG 720
           TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG
Sbjct: 661 TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG 720

Query: 721 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA 780
           QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA
Sbjct: 721 QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA 780

Query: 781 AEE 783
           AEE
Sbjct: 781 AEE 783


>gi|18466802 Ras and Rab interactor 2 [Homo sapiens]
          Length = 895

 Score =  236 bits (601), Expect = 8e-62
 Identities = 157/455 (34%), Positives = 238/455 (52%), Gaps = 30/455 (6%)

Query: 258 SPPAVPPPPVPV-LPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQEVDC 316
           SP   PP   P     A P  +E  PPC   R+  S    +   S  SL    S+     
Sbjct: 395 SPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLS-DMSISTSSSDSLEFDRSMPLFGY 453

Query: 317 GSPSSSEEEGVPGSRGSPATSPHLGRRRPL-------------LRSMSAAFCSLLAPERQ 363
            + ++S  E   G       +P +  ++               L+ +S  F S + PE++
Sbjct: 454 EADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQKVSGVFSSFMTPEKR 513

Query: 364 VGRAAAALMQDRHTAAGQLVQDLLTQVRAGPE-----PQELQGIRQALSRARAMLS--AE 416
           + R  A L +D+ T  G LVQD ++ ++   E        LQ IRQ +++ +  LS  +E
Sbjct: 514 MVRRIAELSRDKCTYFGCLVQDYVSFLQENKECHVSSTDMLQTIRQFMTQVKNYLSQSSE 573

Query: 417 LGP--EKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARA 474
           L P  E L+   +++ VLEK++H  +LKPL+  + A L+    ADGS  +L E L+L R 
Sbjct: 574 LDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFHMADGSWKQLKENLQLVRQ 633

Query: 475 QGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGA 534
           + P   G     P  V++E+++ K + + + YSP  +V  LL+ CKL+Y  +    G   
Sbjct: 634 RNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMY 693

Query: 535 GADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQ 594
           GAD+FLP+L+ V+A CD+ EL  E EYM ELL+PSLL GEGGYYLTS   +L+L+    +
Sbjct: 694 GADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQE 753

Query: 595 AHTLPLSPVQELRRSLSLWEQRR-----LPATHCFQHLLRVAYQDPSSGCTSKTLAVPPE 649
                L    E R +L  W +RR     +P+   FQ+ LRVA+Q+ +SGCT KTL V P 
Sbjct: 754 EQAARLLS-SETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPY 812

Query: 650 ASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRL 684
            +   + Q+CA KF+V  P  + LFL+ ++ + +L
Sbjct: 813 ITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQL 847



 Score =  133 bits (334), Expect = 7e-31
 Identities = 116/373 (31%), Positives = 164/373 (43%), Gaps = 72/373 (19%)

Query: 56  VSLRERLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPS 115
           +S+ +RLL T P+WLQL  +   A  +L+ +PPG FLV KS   Q + L +RLP   G  
Sbjct: 84  LSILDRLLHTHPIWLQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAP 143

Query: 116 FVSSHYILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELE 175
            +    I ES    SLEGS + F DL +LI  YC +RD+L   L+LP AI  A +  +LE
Sbjct: 144 -LKEFAIKESTYTFSLEGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKSEAQLE 202

Query: 176 AISHLGIEFWSSSLNIKAQRGP------AGGPVLP-------------QLKARSPQELD- 215
            ++ +G+ FWSS  + K    P      +   V P              +K R+P EL+ 
Sbjct: 203 ELAQMGLNFWSSPADSKPPNLPPPHRPLSSDGVCPASLRQLCLINGVHSIKTRTPSELEC 262

Query: 216 QGTGAALCFFNPLF----PGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPV---- 267
             T  ALCF NPLF      DL    +    R+     +  T SP  PP  PPP +    
Sbjct: 263 SQTNGALCFINPLFLKVHSQDLSGGLKRPSTRTPNANGTERTRSP--PPRPPPPAINSLH 320

Query: 268 -------------------------PVLPGAVPSQTERLPPCQLLRR----ESSVGYRVP 298
                                      LPG  P+    +PP +L ++    E+  G +  
Sbjct: 321 TSPRLARTETQTSMPETVNHNKHGNVALPGTKPTP---IPPPRLKKQASFLEAEGGAKTL 377

Query: 299 AGSGPSLPPMPSLQEVDCGSPSSSEEEGVPG--SRGSPATSP-----HLGRRRPLLRSMS 351
           +G  P     P L+    GSP  +  E  PG  +R  P +S      H GR+R    S+S
Sbjct: 378 SGGRPGAG--PELELGTAGSPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSDMSIS 435

Query: 352 AAFCSLLAPERQV 364
            +    L  +R +
Sbjct: 436 TSSSDSLEFDRSM 448


>gi|40353729 Ras and Rab interactor 3 [Homo sapiens]
          Length = 985

 Score =  164 bits (415), Expect = 3e-40
 Identities = 143/491 (29%), Positives = 225/491 (45%), Gaps = 41/491 (8%)

Query: 246 KVRVSTETSSPLSPPAV------------PPPPVPVLPGAVPSQ---TERLPPCQLLRRE 290
           K R+S + +S L  P               P P P   G  P+    T+  P       +
Sbjct: 463 KKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQ 522

Query: 291 SSVGYRVPAGS-GPSLPPMPSLQEVDCGSPSSSEEE----GVPGSRGSPATSPHLGRRRP 345
           SS  ++    S   SL       + D  S SS+EEE      P  +  P+      R R 
Sbjct: 523 SSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRL 582

Query: 346 LLRSMSAAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQD-----LLTQVRAGPEPQELQ 400
              S S+ F + L+  R++ +    L QD+ +  G LVQD     L    R     + LQ
Sbjct: 583 SFASFSSMFHAFLSNNRKLYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQ 642

Query: 401 GIRQALSRARAMLSAELGPEKLLSP-----KRLEHVLEKSLHCSVLKPLRPILAARLRRR 455
            IR  +++ ++ L      + L+ P     + LE ++E +L+  VLKPL+  + + L + 
Sbjct: 643 EIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQI 702

Query: 456 LAADGSLGRLAEGLRLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRL 515
            + DGSL +L E   +  A      G   S+P    +E++ QK   + + YSP  ++  L
Sbjct: 703 HSKDGSLQQLKENQLVILATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISIL 762

Query: 516 LQACKLLYMALRT-QEGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGE 574
           L+ CKL+Y ++     G+  GAD+FLP+L  VLA  +L E+LL  EYM EL++P+L  GE
Sbjct: 763 LKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGE 822

Query: 575 GGYYLTSLSASLALLSGLGQAHTLPLSPVQELRRSLSLWEQRRL-----PATHCFQHLLR 629
           G YYLT+   +L  +    +  T+      E++ S+  WE+RR       +    Q  + 
Sbjct: 823 GSYYLTTTYGALEHIKSYDKI-TVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFIC 881

Query: 630 VAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGAL 689
           V+Y +P     ++TLA   +     L   CA KF V +P    LF+  +    +L   AL
Sbjct: 882 VSYLEPEQ--QARTLASRADTQAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDAL 939

Query: 690 AHRLPTTGYLV 700
            H +   GYL+
Sbjct: 940 PHCI--KGYLL 948



 Score =  124 bits (310), Expect = 4e-28
 Identities = 104/327 (31%), Positives = 147/327 (44%), Gaps = 45/327 (13%)

Query: 49  PQRPGRVVSLRERLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRL 108
           P R G  +S+ E+L+ T PVWLQL    A    +L     G FLVR+ ++ +   LC+  
Sbjct: 45  PHRRG--ISILEKLIKTCPVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHF 102

Query: 109 PEASGPSF-VSSHYILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHH 167
           P  +  S  V  + I E    + LEGS L+F D+ +LI  YC +RD+L   L+LP+AI  
Sbjct: 103 PSLNESSAEVLEYTIKEEKSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILE 162

Query: 168 AATHKELEAISHLGIEFWSSSLNIKAQRG-PA--------GGPVLPQLK-----ARSPQE 213
           A++  +LE I++LG+ FW SSLN   +RG PA        G P++  L+     A    E
Sbjct: 163 ASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACE 222

Query: 214 LDQGTG-AALCFFNPLFPGD-----------LGPTKREKFKRSFKVRVSTETSSPLSPPA 261
           ++   G   L F NP+F  D           LG         +      T   +P  PP 
Sbjct: 223 IELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPP- 281

Query: 262 VPPPPV-----------PVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPS 310
            PPPPV           PVLP   P+    LP    +       +       P+ PPM +
Sbjct: 282 -PPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMT 340

Query: 311 LQEVDC---GSPSSSEEEGVPGSRGSP 334
            + + C   G     EE   PG+  SP
Sbjct: 341 CERLPCPTAGLGPLREEAMKPGAASSP 367


>gi|38348206 Ras and Rab interactor-like [Homo sapiens]
          Length = 452

 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 100/342 (29%), Positives = 147/342 (42%), Gaps = 29/342 (8%)

Query: 296 RVPAGSGPSLPPMPSLQEVDCGSPS-----SSEEEGVPGSRGSPATSPHLGRRRPLL--- 347
           R PA  G S    P   EVD   P+       EEE + G        P       +L   
Sbjct: 89  RNPAPHGVSWVKGPLSPEVDHPGPALASLLEEEEEDLEGKEEGREDDPEEEGPEDVLTIH 148

Query: 348 -RSMSAAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQAL 406
            +S+  A  S +A + +  R   A        +G    +LL  VR       L  ++  L
Sbjct: 149 VQSLVRARSSYVARQYRSLRVRIASDSGGPHGSGDPATELLQDVR-----HLLTDLQDHL 203

Query: 407 SRARAMLSAELGPEKLLSPKRLEH---VLEKSLHCSVLKPLRPILAARLRRRLAAD-GSL 462
           ++  + + A  G      PK+ E     LE ++  +VL PL+P L  RLR   A +   L
Sbjct: 204 AKD-SYIRAVFGSRGPGLPKKDEDPGPALETAVCQAVLAPLKPALWTRLRTLRAPELRRL 262

Query: 463 GRLAEGLRLAR----AQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQA 518
            R    LR       AQGPG  G     P+P    ++ ++L  L    +P  +V  LL+ 
Sbjct: 263 RRRQTALRAGAGPPGAQGPGPEGQS---PAPALRSRIHERLAHLHAACAPRRKVALLLEV 319

Query: 519 CKLLYMAL-RTQEGEGAGADEFLPLLSLVLAHC-DLPELLLEAEYMSELLEPSLLTGEGG 576
           C+ +Y  L R +  +  GAD FLP L+  L    D+ +  L+ E++ ELL+P  L GE G
Sbjct: 320 CRDVYAGLARGENQDPLGADAFLPALTEELIWSPDIGDTQLDVEFLMELLDPDELRGEAG 379

Query: 577 YYLTSLSASLALLSGL-GQAHTLPLSPVQELRRSLSLWEQRR 617
           YYLT+   +L  ++    +    P     E R SL  W +RR
Sbjct: 380 YYLTTWFGALHHIAHYQPETDRAPRGLSSEARASLHQWHRRR 421


>gi|108860690 chromosome 16 open reading frame 7 [Homo sapiens]
          Length = 631

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 94/364 (25%), Positives = 135/364 (37%), Gaps = 88/364 (24%)

Query: 258 SPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQEVDCG 317
           +P   PP P P      PSQ+     C L   E S   R P  S    PP P LQ    G
Sbjct: 310 APGCCPPTPNPGSRRLRPSQSLH---CMLSPPEPSAAPR-PQDS----PPTPPLQPGPVG 361

Query: 318 SPS--SSEEEGVPGSRGS-------PATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAA 368
           SPS       G+P    S         TS   GR R +             PE Q+ +  
Sbjct: 362 SPSPLGDTASGLPDKDSSFEDLEQFLGTSERQGRGRGV------------QPEPQLQQLK 409

Query: 369 AALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPEKLLSPKRL 428
            A+ ++ H A  +L+   L            +G+  A S+ R +   E   E   SP   
Sbjct: 410 TAV-EEIHNAVDRLLSLTLLA---------FEGLNTAASKDRCLACIE---EPFFSP--- 453

Query: 429 EHVLEKSLHCSVLKPLRPILAARLRR-RLAADGSLGRLAEGLRLARAQGPGAFGSHLSL- 486
                          L P+L A  R    A + +L R  E   L R   P A G    L 
Sbjct: 454 ---------------LWPLLLALYRSVHRAREAALSRSME---LYRNAPPTAIGIPTKLL 495

Query: 487 PSPVELE--------QVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRT---------Q 529
           P   E +           Q+L  L+    P  +++ +++  +++ +             Q
Sbjct: 496 PQNPEAKGATGYPYCAAAQELGLLVLESCPQKKLECIVRTLRIICVCAEDYCPTPEATPQ 555

Query: 530 EGE------GAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLS 583
            G         GAD+ LP+LS V+    LP+L+ E   + E +    L GE GY LTSL 
Sbjct: 556 AGPPPIAAAAIGADDLLPILSFVVLRSGLPQLVSECAALEEFIHEGYLIGEEGYCLTSLQ 615

Query: 584 ASLA 587
           ++L+
Sbjct: 616 SALS 619


>gi|7657496 RAB guanine nucleotide exchange factor (GEF) 1 [Homo
           sapiens]
          Length = 491

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 31/95 (32%), Positives = 53/95 (55%), Gaps = 2/95 (2%)

Query: 508 PSAQVKRLLQACKLLYMALRTQEGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLE 567
           P  ++  + +  K ++ A++  + E A AD+FLP L  ++   + P L    +Y++    
Sbjct: 284 PRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGNPPRLQSNIQYITRFCN 343

Query: 568 PS-LLTGEGGYYLTSLSASLALLSGLGQAHTLPLS 601
           PS L+TGE GYY T+L  ++A +  L  A +L LS
Sbjct: 344 PSRLMTGEDGYYFTNLCCAVAFIEKL-DAQSLNLS 377


>gi|65288071 tensin 3 [Homo sapiens]
          Length = 1445

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 51/179 (28%), Positives = 82/179 (45%), Gaps = 25/179 (13%)

Query: 3    SPGESGAGSPGAPSPSSFTTGHLAR--EKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE 60
            S G+   GS  +PS S F++ H       P  + L D   AS   +  P  PG  + + +
Sbjct: 1105 SEGDRSLGSV-SPSSSGFSSPHSGSTISIPFPNVLPDFSKASEAASPLPDSPGDKLVIVK 1163

Query: 61   RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNT-RQCQALCMRLPEASGPSFVSS 119
             +  T   W +   +   A+ ML+ + PG+F+VR S++ R    L M++  A+ P  V  
Sbjct: 1164 FVQDTSKFWYKADISREQAIAMLKDKEPGSFIVRDSHSFRGAYGLAMKV--ATPPPSVLQ 1221

Query: 120  --------------HYILE-SPGGVSLEG--SELMFPDLVQLICAYCHTRDILLLPLQL 161
                          H+++E +P GV L+G  +E  F  L  L+C   H+   L LP +L
Sbjct: 1222 LNKKAGDLANELVRHFLIECTPKGVRLKGCSNEPYFGSLTALVCQ--HSITPLALPCKL 1278


>gi|7662302 TBK1 binding protein 1 [Homo sapiens]
          Length = 615

 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 54/179 (30%), Positives = 66/179 (36%), Gaps = 31/179 (17%)

Query: 258 SPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLP-PMPSLQE--- 313
           SPPA   PP P     VP +   +PPC      S    R PA   PS P P+P  +    
Sbjct: 351 SPPARAAPPCPPCQSPVPQRRSPVPPC-----PSPQQRRSPA--SPSCPSPVPQRRSPVP 403

Query: 314 VDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQ 373
             C SPS      VP S   PA  P      P               ER +   A A   
Sbjct: 404 PSCQSPSPQRRSPVPPS--CPAPQPRPPPPPP-------------PGERTLAERAYAKPP 448

Query: 374 DRHTAAGQLVQDLLTQVR-----AGPEPQELQGIRQALSRARAMLSAELGPEKLLSPKR 427
             H  AG   +   +++      AG  P  LQ     L + RA  S   GP + LSP+R
Sbjct: 449 SHHVKAGFQGRRSYSELAEGAAYAGASPPWLQAEAATLPKPRAYGSELYGPGRPLSPRR 507


>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
          Length = 1427

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 46/183 (25%), Positives = 69/183 (37%), Gaps = 12/183 (6%)

Query: 158  PLQLPRAIHHAATHKELEAISHLGIEFWSSSLN--IKAQRGPAGGPVLPQLKARSPQELD 215
            P +   A+  A T + + A++    E+ + ++   I  + G   GPV P     +P+E D
Sbjct: 929  PEETAPAVAAAITQEGMSAVAGFSPEWAALAITVPITEEDGTPEGPVTPATTVHAPEEPD 988

Query: 216  QGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLP-GAV 274
                       P  P    PT  E    +  V    E +SP +  AVPPP  P  P  AV
Sbjct: 989  TAAVRVSTPEEPASPAAAVPTPEEPTSPAAAVPTPEEPTSPAA--AVPPPEEPTSPAAAV 1046

Query: 275  PSQTERLPPCQLL---RRESSVGYRVPAGSGPSLP----PMPSLQEVDCGSPSSSEEEGV 327
            P+  E   P   +      +S    VP    P+ P    P P        +  + EE   
Sbjct: 1047 PTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTS 1106

Query: 328  PGS 330
            P +
Sbjct: 1107 PAA 1109



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 50/226 (22%), Positives = 69/226 (30%), Gaps = 8/226 (3%)

Query: 201  PVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPP 260
            P  P     +P+E      A      P  P    PT  E    +  V    E +SP +  
Sbjct: 1052 PTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAA-- 1109

Query: 261  AVPPPPVPVLP-GAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQEVDCGSP 319
            AVP P  P  P  AVP+  E   P   +          PA   P++P            P
Sbjct: 1110 AVPTPEEPASPAAAVPTPEEPASPAAAVPTPEE-----PAFPAPAVPTPEESASAAVAVP 1164

Query: 320  SSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQDRHTAA 379
            +  E      +  +PA S         L   ++   S+  P   V               
Sbjct: 1165 TPEESASPAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPT 1224

Query: 380  GQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPEKLLSP 425
             +    L   V    EP         L    +  +A L PE+L SP
Sbjct: 1225 SEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSP 1270



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 42/190 (22%), Positives = 65/190 (34%), Gaps = 20/190 (10%)

Query: 201  PVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPP 260
            P  P     +P+E      A      P FP    PT  E    +  V    E++SP +  
Sbjct: 1117 PASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAA-- 1174

Query: 261  AVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPM-PSLQEVD---C 316
            AVP P       AV +  E                  PA S P+   M  +L+E      
Sbjct: 1175 AVPTPAESASFAAVVATLEEPTS--------------PAASVPTPAAMVATLEEFTSPAA 1220

Query: 317  GSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQDRH 376
              P+S E   +  +  +P          P L   +++  ++L PE     AA+    +  
Sbjct: 1221 SVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEP 1280

Query: 377  TAAGQLVQDL 386
             +    V +L
Sbjct: 1281 ASPAAAVSNL 1290


>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate
           3A [Homo sapiens]
          Length = 1115

 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 26/79 (32%), Positives = 39/79 (49%), Gaps = 7/79 (8%)

Query: 264 PPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLP----PMPSLQEVDCGSP 319
           PPP  ++   VPS +    PCQ+L+R   +G+ V  G+    P    P  + +  D    
Sbjct: 18  PPPCALVLAGVPSSSSHPQPCQILKR---IGHAVRVGAVHLQPWTTAPRAASRAPDDSRA 74

Query: 320 SSSEEEGVPGSRGSPATSP 338
            +  +E  PG+R SPA SP
Sbjct: 75  GAQRDEPEPGTRRSPAPSP 93


>gi|157738639 tensin 4 [Homo sapiens]
          Length = 715

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 45/173 (26%), Positives = 75/173 (43%), Gaps = 25/173 (14%)

Query: 3   SPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRERL 62
           +PG   +  PGA SPS+      +  +   D  +            P+ P R +    + 
Sbjct: 391 TPGHQNSVQPGAASPSNPCPATRSNSQTLSDAPFTTC---------PEGPARDMQPTMKF 441

Query: 63  LL-TRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNT-RQCQALCMRLPEA-----SGPS 115
           ++ T   W +       A+ +LR E PG F++R S++ R    L +++ E      S P 
Sbjct: 442 VMDTSKYWFKPNITREQAIELLRKEEPGAFVIRDSSSYRGSFGLALKVQEVPASAQSRPG 501

Query: 116 FVSS----HYILESPG-GVSLEGS--ELMFPDLVQLICAYCHTRDILLLPLQL 161
             S+    H+++ES   GV L+G+  E  F  L   +C   H+   L LP +L
Sbjct: 502 EDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQ--HSIMALALPCKL 552


>gi|119829187 alpha 1 type XVII collagen [Homo sapiens]
          Length = 1497

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 42/148 (28%), Positives = 56/148 (37%), Gaps = 19/148 (12%)

Query: 191 IKAQRGPAGGPVLPQLKA-RSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRV 249
           I+   GP+G P  P L   + PQ L    G       P  PG +               V
Sbjct: 765 IRGPPGPSGDPGKPGLTGPQGPQGLPGTPGRPGIKGEPGAPGKI---------------V 809

Query: 250 STETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG-SGPSLPPM 308
           ++E SS L+ P  P PP  + P   P       P  L   +  +  + P G  GP  PP 
Sbjct: 810 TSEGSSMLTVPGPPGPPGAMGPPGPPGAPGPAGPAGLPGHQEVLNLQGPPGPPGPRGPPG 869

Query: 309 PSLQEVDCGSPSSSEEEGVPGSRGSPAT 336
           PS+       P     EG+PG  G P +
Sbjct: 870 PSIPGPP--GPRGPPGEGLPGPPGPPGS 895



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 45/150 (30%), Positives = 53/150 (35%), Gaps = 27/150 (18%)

Query: 189 LNIKAQRGPAG--GPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFK 246
           LN++   GP G  GP  P +          G G          PG  GP        SF 
Sbjct: 853 LNLQGPPGPPGPRGPPGPSIPGPPGPRGPPGEG---------LPGPPGPPG------SFL 897

Query: 247 VRVSTETSSPLSPPAVPPPPVPV-LPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSL 305
               T  S P  PP  P P      PG    Q E+  P       SS G  +    GP  
Sbjct: 898 SNSETFLSGPPGPPGPPGPKGDQGPPGPRGHQGEQGLPGFSTSGSSSFGLNL---QGPPG 954

Query: 306 PPMPSLQEVDCGSPSSSEEEGVPGSRGSPA 335
           PP P   + D G P      GVPG+ G P+
Sbjct: 955 PPGPQGPKGDKGDP------GVPGALGIPS 978



 Score = 31.6 bits (70), Expect = 3.0
 Identities = 31/121 (25%), Positives = 43/121 (35%), Gaps = 5/121 (4%)

Query: 227 PLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPP--AVPPPPVPVLPGAVPSQTERLPPC 284
           P  PG  GP      +    ++       P  PP  ++P PP P  P          PP 
Sbjct: 835 PGAPGPAGPAGLPGHQEVLNLQGPPGPPGPRGPPGPSIPGPPGPRGPPGEGLPGPPGPPG 894

Query: 285 QLLRRESSVGYRVPAGSGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRR 344
             L    +     P   GP  PP P   +   G      E+G+PG   S ++S  L  + 
Sbjct: 895 SFLSNSETFLSGPP---GPPGPPGPKGDQGPPGPRGHQGEQGLPGFSTSGSSSFGLNLQG 951

Query: 345 P 345
           P
Sbjct: 952 P 952


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 13/86 (15%)

Query: 705 EWPETQGAVTEEEGSGQSEARS----RGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQ 760
           E  E +G   +EEG  + E R+    +GEE+G QG+G+        +   + E   EGG+
Sbjct: 760 EGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEE------EETEGRGEEKEEGGE 813

Query: 761 ---GQAQEGPAQPGEPEAEGSRAAEE 783
              G+ +EG  +  E E EG    EE
Sbjct: 814 VEGGEVEEGKGEREEEEEEGEGEEEE 839



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 30/91 (32%), Positives = 43/91 (47%), Gaps = 13/91 (14%)

Query: 705 EWPETQGAVTEEEGSG--------QSEARSRGEEQGCQGDG-DAGVKASPRDIREQSETT 755
           E  E +G   EEEG G        + E   +GEE+G +G+G + G +       E+ E  
Sbjct: 827 EEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGE 886

Query: 756 AE---GGQGQAQEGPAQPGEPEAEGSRAAEE 783
            E    G+G+ +EG  + GE E EG    EE
Sbjct: 887 GEEEGEGEGEEEEGEGE-GEEEGEGEGEEEE 916



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 5/81 (6%)

Query: 708 ETQGAVTEEEGSGQSE-ARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEG----GQGQ 762
           E +G    ++G G+ E    RGEE+   G+ + G     +  RE+ E   EG    G+G+
Sbjct: 784 EEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE 843

Query: 763 AQEGPAQPGEPEAEGSRAAEE 783
            +EG  +  E E +G    EE
Sbjct: 844 EEEGEGEEEEGEGKGEEEGEE 864



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 24/79 (30%), Positives = 36/79 (45%), Gaps = 3/79 (3%)

Query: 708 ETQGAVTEEEGSGQSEARSRGEEQGCQGDG---DAGVKASPRDIREQSETTAEGGQGQAQ 764
           E +G   EEEG G+ E    GE +  +G+G   + G +       E+ E   E G+G+ +
Sbjct: 890 EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGE 949

Query: 765 EGPAQPGEPEAEGSRAAEE 783
           E   +    E EG    EE
Sbjct: 950 EEEGEWEGEEEEGEGEGEE 968



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 24/85 (28%), Positives = 37/85 (43%), Gaps = 6/85 (7%)

Query: 705 EWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAE------G 758
           E  E +G   EEEG G+ E    GE +  +G+G+   +       E+ E   E       
Sbjct: 870 EGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGE 929

Query: 759 GQGQAQEGPAQPGEPEAEGSRAAEE 783
           G+G+ +EG  +  + E EG     E
Sbjct: 930 GEGEEEEGEGEGEDGEGEGEEEEGE 954



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 27/88 (30%), Positives = 38/88 (43%), Gaps = 12/88 (13%)

Query: 708 ETQGAVTEEEGSGQSE-----ARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEG---- 758
           E +G   EEEG G+ E         GEE+  +G+G+ G      +  E      EG    
Sbjct: 907 EGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEG 966

Query: 759 ---GQGQAQEGPAQPGEPEAEGSRAAEE 783
              G+G+ +EG  +  E E EG    EE
Sbjct: 967 EEEGEGEGEEGEGEGEEEEGEGEGEEEE 994



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 24/79 (30%), Positives = 35/79 (44%), Gaps = 10/79 (12%)

Query: 705  EWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQ 764
            E  E +G    EE  G+ E    GE +G +G+G+           E+ E   EG + + +
Sbjct: 947  EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEG----------EEEEGEGEGEEEEGE 996

Query: 765  EGPAQPGEPEAEGSRAAEE 783
            E   + GE E EG    EE
Sbjct: 997  EEGEEEGEGEEEGEGEGEE 1015



 Score = 38.1 bits (87), Expect = 0.032
 Identities = 24/80 (30%), Positives = 37/80 (46%), Gaps = 3/80 (3%)

Query: 705  EWPETQGAVTEEEGSGQSE-ARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQA 763
            E  E +G   EEEG G+ E     GEE+  +G+ +   +    +  E+ E   E G+G+ 
Sbjct: 924  EGEEGEGEGEEEEGEGEGEDGEGEGEEE--EGEWEGEEEEGEGEGEEEGEGEGEEGEGEG 981

Query: 764  QEGPAQPGEPEAEGSRAAEE 783
            +E   +    E EG    EE
Sbjct: 982  EEEEGEGEGEEEEGEEEGEE 1001



 Score = 36.6 bits (83), Expect = 0.092
 Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 7/79 (8%)

Query: 705  EWPETQGAVTEEEGSGQSE---ARSRGEEQG---CQGDGDAGVKASPRDIREQSETTAEG 758
            E  E +G   EEEG G+ E       GEE+G    +G+G+ G +    ++  + E     
Sbjct: 973  EGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGE-GEEEEEGEVEGEVEGEEGE 1031

Query: 759  GQGQAQEGPAQPGEPEAEG 777
            G+G+ +EG  +  E E EG
Sbjct: 1032 GEGEEEEGEEEGEEREKEG 1050



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 2/76 (2%)

Query: 708 ETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGP 767
           E +G    EE  G+ E    GE +G + +G+   K        + E   E G+G+ ++G 
Sbjct: 888 EEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEG--KGEEEGEEGEGEGEEEEGEGEGEDGE 945

Query: 768 AQPGEPEAEGSRAAEE 783
            +  E E E     EE
Sbjct: 946 GEGEEEEGEWEGEEEE 961



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 24/80 (30%), Positives = 37/80 (46%), Gaps = 7/80 (8%)

Query: 705 EWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEG-GQGQA 763
           E  E +G    EEG G+      GEE+  +G+G+   +    +   + E   EG G+G+ 
Sbjct: 861 EGEEGEGEEEGEEGEGE------GEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEE 914

Query: 764 QEGPAQPGEPEAEGSRAAEE 783
           +EG  +  E   EG    EE
Sbjct: 915 EEGEGKGEEEGEEGEGEGEE 934



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 25/72 (34%), Positives = 36/72 (50%), Gaps = 5/72 (6%)

Query: 715  EEEGSGQSE-ARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEG-GQGQAQEGPAQPGE 772
            EEEG G+ E     GEE+  +G+G+   +    +  E+ E   EG G+G+ +E     GE
Sbjct: 967  EEEGEGEGEEGEGEGEEEEGEGEGEE--EEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGE 1024

Query: 773  PEA-EGSRAAEE 783
             E  EG    EE
Sbjct: 1025 VEGEEGEGEGEE 1036



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 1/65 (1%)

Query: 708  ETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGP 767
            E +G V  EEG G+ E    GEE+G + + +   + + R+  E+ E   +  +   +E  
Sbjct: 1020 EVEGEVEGEEGEGEGE-EEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENE 1078

Query: 768  AQPGE 772
             Q GE
Sbjct: 1079 RQDGE 1083



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 2/82 (2%)

Query: 703 RAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQ 762
           + EW +  G   E++   Q   + R +E    G+ + G        RE+ E   EG   +
Sbjct: 699 KEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEK-EGEGKE 757

Query: 763 AQEGPAQPGEPEAE-GSRAAEE 783
             EG    GE E E G R  EE
Sbjct: 758 EGEGEEVEGEREKEEGERKKEE 779



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 22/81 (27%), Positives = 34/81 (41%), Gaps = 11/81 (13%)

Query: 703 RAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQ 762
           + E  E +G   EE    + E    GE +  +G+G+           E+ E   E G+G+
Sbjct: 808 KEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE----------EEEGEGEEEEGEGK 857

Query: 763 AQEGPAQPGEPEAEGSRAAEE 783
            +E   + GE E EG     E
Sbjct: 858 GEE-EGEEGEGEEEGEEGEGE 877



 Score = 30.0 bits (66), Expect = 8.6
 Identities = 17/64 (26%), Positives = 30/64 (46%), Gaps = 1/64 (1%)

Query: 715 EEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQ-PGEP 773
           EEE  G+ +    GEE   + + + G +       ++ +   EG QG+ +E   +  GE 
Sbjct: 748 EEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEE 807

Query: 774 EAEG 777
           + EG
Sbjct: 808 KEEG 811


>gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens]
          Length = 211

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 31/82 (37%), Positives = 41/82 (50%), Gaps = 5/82 (6%)

Query: 83  LRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGVSLEGSELMFPDLV 142
           LR EP GTFLVR S  R C    + +  ASGP+ +  H+     G   L+GS   F  L 
Sbjct: 93  LRAEPVGTFLVRDSRQRNC-FFALSVKMASGPTSIRVHF---QAGRFHLDGSRESFDCLF 148

Query: 143 QLICAY-CHTRDILLLPLQLPR 163
           +L+  Y    R +L  PL+  R
Sbjct: 149 ELLEHYVAAPRRMLGAPLRQRR 170


>gi|208022661 hypothetical protein LOC57701 [Homo sapiens]
          Length = 1334

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 63/243 (25%), Positives = 87/243 (35%), Gaps = 53/243 (21%)

Query: 260 PAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQEVDCGSP 319
           P+  PPP P+     P  T  +P    + R             P +PP P L E     P
Sbjct: 570 PSPEPPPSPLQVPTYPQLTLEVPQAPEVLR------------SPGVPPSPCLPE---SYP 614

Query: 320 SSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQDRHTAA 379
             S +E      GS   SPH GRR P   S   +  S     R+ G   +  ++DR  A 
Sbjct: 615 YGSPQEKSLDKAGS--ESPHPGRRTPGNSSKKPSQGS----GRRPGDPGSTPLRDRLAAL 668

Query: 380 GQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPEKLLSPKRLEHVLEKSLHCS 439
           G+L        + GPE         AL   +  + A  G EK   P +        +   
Sbjct: 669 GKL--------KTGPE--------GALGSEKNGVPARPGTEKTRGPGKSGESAGDMV--- 709

Query: 440 VLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAFG-------SHLSLPSPVEL 492
                 P +   L +  A  G  G +A G    + Q PG  G       S  S+ + V+L
Sbjct: 710 ------PSIHRPLEQLEAKGGIRGAVALGTNSLKQQEPGLMGDPGARVYSSHSMGARVDL 763

Query: 493 EQV 495
           E V
Sbjct: 764 EPV 766


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 54/211 (25%), Positives = 82/211 (38%), Gaps = 22/211 (10%)

Query: 224 FFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVP-PPPVPVLP---GAVPSQTE 279
           FF+   P   GP+   +   S     S+ T+  + PP  P PPP P  P    + P    
Sbjct: 794 FFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVA 853

Query: 280 RLPPCQLLRRESSVG-YRVPAGS---GPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPA 335
           +LP  + +      G  R   G+    PSL  M  L+ V           G PG   +PA
Sbjct: 854 KLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSV-----------GAPGGAPTPA 902

Query: 336 TSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPE 395
             P    ++PL R++S     + AP    G  AA  ++    AA + +           E
Sbjct: 903 LGPS-APQKPLRRALSGRASPVPAPSS--GLHAAVRLKACSLAASEGLSSAQPNGPPEAE 959

Query: 396 PQELQGIRQALSRARAMLSAELGPEKLLSPK 426
           P+  Q      S   +  S +L  E+ +SP+
Sbjct: 960 PRPPQSPASTASFIFSKGSRKLQLERPVSPE 990


>gi|89941470 ankyrin repeat domain 34 [Homo sapiens]
          Length = 496

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 51/176 (28%), Positives = 69/176 (39%), Gaps = 25/176 (14%)

Query: 193 AQRGPAGGPVLPQLKARSPQELDQGTGAA--LCFFNPL---FPGDLGPTKREKFKRSFKV 247
           A++  +GGP+  +  A   QE    +G    L    P+    PG L P   E  + S + 
Sbjct: 302 AEKVTSGGPLSRRNTAPEAQESGPPSGLRQKLSRMEPVELDTPGHLCPDSPESSRLSLER 361

Query: 248 RVSTETSSPLSPPAVPPPPVP-----VLPGAV-PSQTERLPPCQLLRRESSV-------- 293
           R    ++SPL+ P     P P      LPGAV P    R  P  L RR S          
Sbjct: 362 R--RYSASPLTLPPAGSAPSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQ 419

Query: 294 ---GYRVPAGSGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPL 346
              G+  P    P  PP+P ++    G   S       G+ GSP T   L RR  +
Sbjct: 420 TRPGFLPPLNVSPH-PPIPDIRPQPGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSM 474


>gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]
          Length = 1466

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 46/152 (30%), Positives = 54/152 (35%), Gaps = 21/152 (13%)

Query: 195 RGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETS 254
           RGP G P+ P   A  P   D+G G A     P  PG  GP            R S    
Sbjct: 761 RGPTG-PIGPPGPAGQPG--DKGEGGA-----PGLPGIAGP------------RGSPGER 800

Query: 255 SPLSPPAVPP-PPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQE 313
               PP     P  P   G    + ER  P +            P GSGP+ PP P   +
Sbjct: 801 GETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVK 860

Query: 314 VDCGSPSSSEEEGVPGSRGSPATSPHLGRRRP 345
            + GSP      G PG+RG P      G   P
Sbjct: 861 GERGSPGGPGAAGFPGARGLPGPPGSNGNPGP 892



 Score = 30.4 bits (67), Expect = 6.6
 Identities = 42/170 (24%), Positives = 57/170 (33%), Gaps = 33/170 (19%)

Query: 190 NIKAQRGPAGGPVLPQLKARS--------PQELDQGTGAALCFFNPLFPGDLGPTKRE-K 240
           N +  +GP G P  P +  R+        P          +C   P  P +  P      
Sbjct: 100 NGQGPQGPKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYD 159

Query: 241 FKRSFKVRVSTETSSPLSPPAVPPPP-VPVLPGAVPSQTERLPPCQLLRRESSVGYRVPA 299
            K    V        P  PP  P PP     PG+  S   + PP +            P 
Sbjct: 160 VKSGVAVGGLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGE------------PG 207

Query: 300 GSGPSLPP---------MPSLQEVDCGSPSSSEEEGVPGSRG--SPATSP 338
            +GPS PP          P+ ++ + G P    E G+PG  G   PA  P
Sbjct: 208 QAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPGERGLPGPPGIKGPAGIP 257



 Score = 30.0 bits (66), Expect = 8.6
 Identities = 44/158 (27%), Positives = 58/158 (36%), Gaps = 17/158 (10%)

Query: 249  VSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG----SGPS 304
            V  E  SP  P A   P    LPG   S     PP        S G   P G    +G  
Sbjct: 859  VKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGP----SGSPGKDGPPGPAGNTGAP 914

Query: 305  LPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQV 364
              P  S  + D G P    E+G PG++G P     LG     +  ++ A   L  P    
Sbjct: 915  GSPGVSGPKGDAGQPG---EKGSPGAQGPPGAPGPLG-----IAGITGA-RGLAGPPGMP 965

Query: 365  GRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGI 402
            G   +   Q     +G+   + L+  R  P PQ L G+
Sbjct: 966  GPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGL 1003


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 39/151 (25%), Positives = 57/151 (37%), Gaps = 32/151 (21%)

Query: 193  AQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTE 252
            A   P GGP  P  K                  +P  P    P+ +E        +V+T 
Sbjct: 1448 ATSAPKGGPATPSSKG-----------------DPTLPAVTPPSPKEP---PAPKQVAT- 1486

Query: 253  TSSPLSPPAVPPPP-VPVLPGAVPSQTERLPPCQLLRRE------SSVGYRVPAGSGPSL 305
            +SSP   PA P P   P LP  +PS  + +P     RR+      + +  + PA   P  
Sbjct: 1487 SSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKE 1546

Query: 306  PPMPSLQEVDCGSPSSSEEEGVPGSRGSPAT 336
              +P    V    PS  +   +P  + +PAT
Sbjct: 1547 ALIPPAMTV----PSPKKTPAIPTPKEAPAT 1573



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 28/96 (29%), Positives = 39/96 (40%), Gaps = 13/96 (13%)

Query: 258  SPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQEVDCG 317
            +PPA  PP     PG  P +    PP        +V    P G+ P+LP      +    
Sbjct: 1311 TPPAATPPSPKGSPGTPPPKGAPTPP--------AVTPPSPKGT-PTLPATTPSSKGGPT 1361

Query: 318  SPSSSE----EEGVPGSRGSPATSPHLGRRRPLLRS 349
            +PSS E        P  +G PA +P   +R P + S
Sbjct: 1362 TPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPS 1397



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 49/193 (25%), Positives = 66/193 (34%), Gaps = 43/193 (22%)

Query: 186  SSSLNIKAQRGPAGGPVLPQLKARSPQE------------------LDQGTGAALCFFNP 227
            SS     A   P G P LP +   SP+E                  L + T A L     
Sbjct: 1488 SSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEA 1547

Query: 228  LFPGDL---GPTKREKFKRSFKVRVSTETSSPLSPPAV--------PPPPVPVLPGAV-- 274
            L P  +    P K        +   +  +    SPPAV        P P   ++P AV  
Sbjct: 1548 LIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTS 1607

Query: 275  PSQTERLPPCQLLRRESSVGYRVPAGSG-PSLPPM-PSLQEVDCGSPSS----------S 322
            PS  E   P  +       G   PA  G P+ PP+ PS  +    SP+S           
Sbjct: 1608 PSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQ 1667

Query: 323  EEEGVPGSRGSPA 335
              +G+P  +G  A
Sbjct: 1668 ASKGLPAKKGPTA 1680



 Score = 31.2 bits (69), Expect = 3.9
 Identities = 54/249 (21%), Positives = 94/249 (37%), Gaps = 13/249 (5%)

Query: 198  AGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPL 257
            A  P+LP  K  S  +  +G  A+     PL P +   +         KV    E++S  
Sbjct: 1734 APAPLLPVQKDSS--KTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVS 1791

Query: 258  SPPAVPPPPVPVLPGAVPS---QTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQEV 314
            + P+ PP  +P+ P  VP+   + + LP    L  ES      PA     LP +P  + +
Sbjct: 1792 AAPS-PPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPP-EPI 1849

Query: 315  DCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQD 374
              G P  S    +P  + +    P    ++P+ ++   +       E     +   L + 
Sbjct: 1850 SGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGS-----GTESDSDESVPELEEQ 1904

Query: 375  RHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPEKLLSPKRLEHVLEK 434
              T A      L        EP       ++  +AR  +S +LG  ++    R+     K
Sbjct: 1905 DSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMS-KLGLRQVTGVTRVTIRKSK 1963

Query: 435  SLHCSVLKP 443
            ++   + KP
Sbjct: 1964 NILFVITKP 1972



 Score = 30.4 bits (67), Expect = 6.6
 Identities = 30/106 (28%), Positives = 38/106 (35%), Gaps = 25/106 (23%)

Query: 255  SPLSPPAVPPPPVPVL----PGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPM-- 308
            +P +P A PP P   L    P   P+     PP          G   P   G   PP   
Sbjct: 1217 APTTPAATPPSPKGGLATPSPKGAPTTPAATPP------SPKGGPATPPPKGAPTPPAAT 1270

Query: 309  -PSLQEVDCGSPSSSEEEGVPGS--------RGSPATSPHLGRRRP 345
             PSL+    G  ++   +G P          +G PATSP  G   P
Sbjct: 1271 PPSLK----GGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTP 1312



 Score = 30.0 bits (66), Expect = 8.6
 Identities = 36/154 (23%), Positives = 53/154 (34%), Gaps = 12/154 (7%)

Query: 197 PAGGPVLPQLKARSPQELDQGTGAALC-FFNPLFPGDLG--PTKREKFKRSFKVRVSTET 253
           P G  V PQ K    ++   G    +    +P+ P +    P     F+ S     +T +
Sbjct: 796 PLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHS 855

Query: 254 SSPLSPPAVPPPPV--PVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSL 311
            +P SP   P P    P+ P  V    +  P        S V    P   GP+ P     
Sbjct: 856 PTPPSPKGAPTPSAVTPLSPKGVTLPPKETPT------PSVVNLPFPK-EGPATPAPKQA 908

Query: 312 QEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRP 345
             +   S S  +    P  +G PA+    G   P
Sbjct: 909 PALSMTSSSPKKARATPAPKGIPASPSPKGAPTP 942



 Score = 30.0 bits (66), Expect = 8.6
 Identities = 24/88 (27%), Positives = 33/88 (37%), Gaps = 15/88 (17%)

Query: 258  SPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQEVDCG 317
            +PPAV PP     P A P       P              PA + PS    P+   +  G
Sbjct: 1010 TPPAVTPPSPKGSPAATPFPKGASTP--------------PAATPPSPKGSPAATPLPKG 1055

Query: 318  SPSSSEEEGVPGSRGSPATSPHLGRRRP 345
            +P++     +P  +G PAT    G   P
Sbjct: 1056 APTTPAAT-LPSPKGGPATPSLKGAPTP 1082


>gi|155030232 proline, glutamic acid and leucine rich protein 1
           [Homo sapiens]
          Length = 1130

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 36/100 (36%), Positives = 38/100 (38%), Gaps = 18/100 (18%)

Query: 256 PLSPPAVP-----PPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPS 310
           P  PP  P     P P PV P   PS   R PP        SVG    AG  PS  PMPS
Sbjct: 633 PRVPPLQPMGPTCPTPAPVPPPEAPSPF-RAPPFHPPGPMPSVGSMPSAGPMPSAGPMPS 691

Query: 311 LQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSM 350
              V    P            G P T+ HLG   P L S+
Sbjct: 692 AGPVPSARP------------GPPTTANHLGLSVPGLVSV 719



 Score = 34.7 bits (78), Expect = 0.35
 Identities = 29/74 (39%), Positives = 33/74 (44%), Gaps = 23/74 (31%)

Query: 256 PLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQE-- 313
           PL PP  PPPPV   PG V      LPP QL      V    P G GP     P+L+E  
Sbjct: 838 PLPPPPPPPPPV---PGPV-----TLPPPQL------VPEGTPGGGGP-----PALEEDL 878

Query: 314 --VDCGSPSSSEEE 325
             ++  S    EEE
Sbjct: 879 TVININSSDEEEEE 892



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 28/90 (31%), Positives = 34/90 (37%), Gaps = 15/90 (16%)

Query: 259 PPAVPPPPV-----PVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQE 313
           PP  PPPP      P+ P   P+ +  +P     + E      +PA  GP  PP P    
Sbjct: 796 PPLPPPPPSGATPPPIAPTGPPTASPPVPA----KEEPE---ELPAAPGPLPPPPPPPPP 848

Query: 314 VDCG---SPSSSEEEGVPGSRGSPATSPHL 340
           V       P     EG PG  G PA    L
Sbjct: 849 VPGPVTLPPPQLVPEGTPGGGGPPALEEDL 878


>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
           exchanger), member 1 [Homo sapiens]
          Length = 1099

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 3/78 (3%)

Query: 705 EWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQ 764
           E  E  G  T+ EG G++E + +GEE  C+ + +A  K    +  ++ E  AE G+ +  
Sbjct: 768 ETEEKSGGETQPEGEGETETQGKGEE--CEDENEAEGKGD-NEGEDEGEIHAEDGEMKGN 824

Query: 765 EGPAQPGEPEAEGSRAAE 782
           EG  +  E  AE    A+
Sbjct: 825 EGETESQELSAENHGEAK 842



 Score = 34.7 bits (78), Expect = 0.35
 Identities = 19/76 (25%), Positives = 34/76 (44%), Gaps = 1/76 (1%)

Query: 708 ETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGP 767
           E  G   E  G G++E +S GE Q  +G+G+   +    +  +++E   +G      EG 
Sbjct: 755 EMPGEEGETAGEGETEEKSGGETQP-EGEGETETQGKGEECEDENEAEGKGDNEGEDEGE 813

Query: 768 AQPGEPEAEGSRAAEE 783
               + E +G+    E
Sbjct: 814 IHAEDGEMKGNEGETE 829


>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
           interacting protein [Homo sapiens]
          Length = 1211

 Score = 39.7 bits (91), Expect = 0.011
 Identities = 53/191 (27%), Positives = 71/191 (37%), Gaps = 36/191 (18%)

Query: 256 PLSPPAVPPPPVP---VLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQ 312
           PLSPP  PPPP+P     P +  S   R P   L +  + + + VP    P LPP     
Sbjct: 753 PLSPP--PPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPP----- 805

Query: 313 EVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALM 372
            V C  P          SRG       LG RR     MS         E   G     L 
Sbjct: 806 PVPCAPPML--------SRG-------LGHRRSETSHMSVKRLRWEQVENSEGTIWGQLG 850

Query: 373 QDR-HTAAGQLVQDLLTQVR----------AGPEPQELQGIRQALSRARAMLSAELGPEK 421
           +D  +     +V+ L  ++            GPEP   + + + LS  +A  ++ L    
Sbjct: 851 EDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHL 910

Query: 422 LLSPKRLEHVL 432
            LSP  L  VL
Sbjct: 911 KLSPAELRQVL 921



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 45/163 (27%), Positives = 57/163 (34%), Gaps = 9/163 (5%)

Query: 186 SSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFF-NPLFPGDLGPTKREKFKRS 244
           S  L      GP+  P +P      P E   G G +L    NP     +      +   S
Sbjct: 509 SQGLEAGLSCGPSECPEMPL--PLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSS 566

Query: 245 FKVRVSTETSSPLSPPAVPPPPVPVLP---GAVPSQTERLPPCQLLRRESSVGYRVPAGS 301
           FK ++ T + S  SPP  P P V   P     V   +ERL P        S G   P+ S
Sbjct: 567 FKGKMGTVSKSRASPPG-PSPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSS 625

Query: 302 GPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRR 344
                P  SL      SP        P S  SP  +    RR+
Sbjct: 626 --ESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPPSRRK 666


>gi|150378503 leiomodin 2 (cardiac) [Homo sapiens]
          Length = 547

 Score = 39.7 bits (91), Expect = 0.011
 Identities = 32/92 (34%), Positives = 42/92 (45%), Gaps = 15/92 (16%)

Query: 192 KAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVST 251
           K Q G  GGP L        +   +GT ++  + +P       P    K  +    +V T
Sbjct: 364 KQQEGYDGGPNL------RTKVWQRGTPSSSPYVSPRH----SPWSSPKLPK----KVQT 409

Query: 252 ETSSPLSPPAVPPPPVPVLPGAVPSQTERLPP 283
             S PLSP A PPPP P  P   PS ++RLPP
Sbjct: 410 VRSRPLSPVATPPPPPPPPPPPPPS-SQRLPP 440


>gi|170763515 DMRT-like family A1 [Homo sapiens]
          Length = 504

 Score = 39.7 bits (91), Expect = 0.011
 Identities = 39/126 (30%), Positives = 53/126 (42%), Gaps = 16/126 (12%)

Query: 261 AVPPPPVPVLPGAVPSQTE-----RLPPCQLLRRESSVGYRVPAGSGP-SLPPMPSLQE- 313
           A PPPP P LP  VPS  +       PP   LR  ++      A SG    PP P L+  
Sbjct: 26  AAPPPPSPALP--VPSGMQVPPAFLRPPSLFLRAAAAAAAAAAATSGSGGCPPAPGLESG 83

Query: 314 ---VDCGSPSSSEEEGVPGSRGSPATSPHLGRRR-PLLRSMSAAFCSLLAPERQVGRAAA 369
              V CG P + +       R     S   G +R    R  + A C+L+A  ++V  A  
Sbjct: 84  VGAVGCGYPRTPK---CARCRNHGVVSALKGHKRFCRWRDCACAKCTLIAERQRVMAAQV 140

Query: 370 ALMQDR 375
           AL + +
Sbjct: 141 ALRRQQ 146


>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
          Length = 1263

 Score = 39.3 bits (90), Expect = 0.014
 Identities = 31/87 (35%), Positives = 38/87 (43%), Gaps = 11/87 (12%)

Query: 259 PPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQE-VDCG 317
           PP  PPPP P LPG V   +   PP   L   +++    P     ++PP P L E V   
Sbjct: 601 PPPPPPPPPPPLPGGVCISS---PPS--LPGGTAISPPPPLSGDATIPPPPPLPEGVGIP 655

Query: 318 SPSSSEEEGVPGSRGSPATSPHLGRRR 344
           SPSS     +PG    P   P  G  R
Sbjct: 656 SPSS-----LPGGTAIPPPPPLPGSAR 677



 Score = 33.1 bits (74), Expect = 1.0
 Identities = 28/94 (29%), Positives = 33/94 (35%), Gaps = 28/94 (29%)

Query: 259 PPAVP-----PPPVPVLPGA--VPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSL 311
           PP +P     PPP P LPG+  +P     LP                AG  P  PP+P  
Sbjct: 669 PPPLPGSARIPPPPPPLPGSAGIPPPPPPLPG--------------EAGMPPPPPPLP-- 712

Query: 312 QEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRP 345
                G P        PG  G P   P +G   P
Sbjct: 713 -----GGPGIPPPPPFPGGPGIPPPPPGMGMPPP 741


>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
          Length = 1272

 Score = 39.3 bits (90), Expect = 0.014
 Identities = 31/87 (35%), Positives = 38/87 (43%), Gaps = 11/87 (12%)

Query: 259 PPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQE-VDCG 317
           PP  PPPP P LPG V   +   PP   L   +++    P     ++PP P L E V   
Sbjct: 610 PPPPPPPPPPPLPGGVCISS---PPS--LPGGTAISPPPPLSGDATIPPPPPLPEGVGIP 664

Query: 318 SPSSSEEEGVPGSRGSPATSPHLGRRR 344
           SPSS     +PG    P   P  G  R
Sbjct: 665 SPSS-----LPGGTAIPPPPPLPGSAR 686



 Score = 33.1 bits (74), Expect = 1.0
 Identities = 28/94 (29%), Positives = 33/94 (35%), Gaps = 28/94 (29%)

Query: 259 PPAVP-----PPPVPVLPGA--VPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSL 311
           PP +P     PPP P LPG+  +P     LP                AG  P  PP+P  
Sbjct: 678 PPPLPGSARIPPPPPPLPGSAGIPPPPPPLPG--------------EAGMPPPPPPLP-- 721

Query: 312 QEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRP 345
                G P        PG  G P   P +G   P
Sbjct: 722 -----GGPGIPPPPPFPGGPGIPPPPPGMGMPPP 750


>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 39.3 bits (90), Expect = 0.014
 Identities = 29/80 (36%), Positives = 33/80 (41%), Gaps = 16/80 (20%)

Query: 256 PLSPPAVP-PPPVPVLPGAVPSQTERLPPCQLLRRESSVGY-RVPAGSGPSLPPMP---- 309
           PL PPA P PPP P LP A P       PC         G+ + P  S P+L P P    
Sbjct: 395 PLPPPAPPLPPPAPPLPPAAPPL-----PCAQKAAHPPAGFTKTPKSSSPALKPKPNPPS 449

Query: 310 -----SLQEVDCGSPSSSEE 324
                S   VD   PS  E+
Sbjct: 450 PENTASSAPVDWRDPSQMEK 469



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 39/163 (23%), Positives = 59/163 (36%), Gaps = 39/163 (23%)

Query: 181 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK 240
           G+  W S + +  ++  A        +A  P+   +  G+AL            P     
Sbjct: 254 GVTKWKSDVALNGRQAEA-------TRASPPRSPAEPKGSAL---------GPNPEPHLT 297

Query: 241 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG 300
           F RSFKV                PPP PV   ++P Q  +  P    R+E     + P  
Sbjct: 298 FPRSFKV----------------PPPTPVRTSSIPVQEAQEAP----RKEEGATKKAP-- 335

Query: 301 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGS-RGSPATSPHLGR 342
           S   LPP   ++      P  + E   PG  + +   SP LG+
Sbjct: 336 SRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQ 378


>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 39.3 bits (90), Expect = 0.014
 Identities = 29/80 (36%), Positives = 33/80 (41%), Gaps = 16/80 (20%)

Query: 256 PLSPPAVP-PPPVPVLPGAVPSQTERLPPCQLLRRESSVGY-RVPAGSGPSLPPMP---- 309
           PL PPA P PPP P LP A P       PC         G+ + P  S P+L P P    
Sbjct: 395 PLPPPAPPLPPPAPPLPPAAPPL-----PCAQKAAHPPAGFTKTPKSSSPALKPKPNPPS 449

Query: 310 -----SLQEVDCGSPSSSEE 324
                S   VD   PS  E+
Sbjct: 450 PENTASSAPVDWRDPSQMEK 469



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 39/163 (23%), Positives = 59/163 (36%), Gaps = 39/163 (23%)

Query: 181 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK 240
           G+  W S + +  ++  A        +A  P+   +  G+AL            P     
Sbjct: 254 GVTKWKSDVALNGRQAEA-------TRASPPRSPAEPKGSAL---------GPNPEPHLT 297

Query: 241 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG 300
           F RSFKV                PPP PV   ++P Q  +  P    R+E     + P  
Sbjct: 298 FPRSFKV----------------PPPTPVRTSSIPVQEAQEAP----RKEEGATKKAP-- 335

Query: 301 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGS-RGSPATSPHLGR 342
           S   LPP   ++      P  + E   PG  + +   SP LG+
Sbjct: 336 SRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQ 378


>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo
           sapiens]
          Length = 1188

 Score = 39.3 bits (90), Expect = 0.014
 Identities = 29/80 (36%), Positives = 33/80 (41%), Gaps = 16/80 (20%)

Query: 256 PLSPPAVP-PPPVPVLPGAVPSQTERLPPCQLLRRESSVGY-RVPAGSGPSLPPMP---- 309
           PL PPA P PPP P LP A P       PC         G+ + P  S P+L P P    
Sbjct: 395 PLPPPAPPLPPPAPPLPPAAPPL-----PCAQKAAHPPAGFTKTPKSSSPALKPKPNPPS 449

Query: 310 -----SLQEVDCGSPSSSEE 324
                S   VD   PS  E+
Sbjct: 450 PENTASSAPVDWRDPSQMEK 469



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 39/163 (23%), Positives = 59/163 (36%), Gaps = 39/163 (23%)

Query: 181 GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK 240
           G+  W S + +  ++  A        +A  P+   +  G+AL            P     
Sbjct: 254 GVTKWKSDVALNGRQAEA-------TRASPPRSPAEPKGSAL---------GPNPEPHLT 297

Query: 241 FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG 300
           F RSFKV                PPP PV   ++P Q  +  P    R+E     + P  
Sbjct: 298 FPRSFKV----------------PPPTPVRTSSIPVQEAQEAP----RKEEGATKKAP-- 335

Query: 301 SGPSLPPMPSLQEVDCGSPSSSEEEGVPGS-RGSPATSPHLGR 342
           S   LPP   ++      P  + E   PG  + +   SP LG+
Sbjct: 336 SRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQ 378


>gi|149944516 tet oncogene family member 3 [Homo sapiens]
          Length = 1660

 Score = 39.3 bits (90), Expect = 0.014
 Identities = 45/158 (28%), Positives = 61/158 (38%), Gaps = 23/158 (14%)

Query: 197 PAGGPV-----LPQLK--ARSPQELDQGTGAALCFFNPLFPGDLGPTKR---EKFKRSFK 246
           PAGGPV      P +K   R P ++ +          PLFP    P ++   E  +    
Sbjct: 450 PAGGPVGTEKAAPGIKPSVRKPIQIKKSRPREA---QPLFP----PVRQIVLEGLRSPAS 502

Query: 247 VRVSTETSSPLSPP---AVPPPPVPVLP--GAVPSQTERLPPCQLLRRESSVGYRVPAGS 301
             V     +PL      AVP PP P L      PS+   LPP Q +R  S +    P  +
Sbjct: 503 QEVQAHPPAPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGST 562

Query: 302 GPSLPPMPSLQE-VDCGSPSSSEEEGVPGSRGSPATSP 338
           GP  P    L+E +        +  G+PG    P   P
Sbjct: 563 GPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDP 600


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,389,570
Number of Sequences: 37866
Number of extensions: 2157527
Number of successful extensions: 17511
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 83
Number of HSP's successfully gapped in prelim test: 554
Number of HSP's that attempted gapping in prelim test: 13551
Number of HSP's gapped (non-prelim): 3803
length of query: 783
length of database: 18,247,518
effective HSP length: 110
effective length of query: 673
effective length of database: 14,082,258
effective search space: 9477359634
effective search space used: 9477359634
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.