BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens] (250 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens] 485 e-137 gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens] 479 e-135 gi|4506189 proteasome alpha 7 subunit [Homo sapiens] 416 e-116 gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens] 392 e-109 gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens] 169 3e-42 gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens] 169 3e-42 gi|4506181 proteasome subunit alpha type 2 [Homo sapiens] 159 3e-39 gi|23110942 proteasome alpha 5 subunit [Homo sapiens] 157 6e-39 gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens] 141 6e-34 gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens] 141 6e-34 gi|23110944 proteasome alpha 6 subunit [Homo sapiens] 124 6e-29 gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens] 122 4e-28 gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens] 117 7e-27 gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens] 116 2e-26 gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens] 83 3e-16 gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens] 49 5e-06 gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens] 49 5e-06 gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens] 49 5e-06 gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens] 43 2e-04 gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo... 41 0.001 gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo ... 41 0.001 gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens] 37 0.021 gi|70980531 GGA binding partner [Homo sapiens] 34 0.10 gi|4506193 proteasome beta 1 subunit [Homo sapiens] 33 0.23 gi|222144262 proteasome beta 5 subunit isoform 3 [Homo sapiens] 29 3.4 gi|102467242 inner centromere protein antigens 135/155kDa isofor... 29 3.4 gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 29 4.4 gi|109255234 centrosomal protein 290kDa [Homo sapiens] 28 5.8 gi|4506411 Ran GTPase activating protein 1 [Homo sapiens] 28 5.8 gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 28 7.5 >gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens] Length = 250 Score = 485 bits (1249), Expect = e-137 Identities = 250/250 (100%), Positives = 250/250 (100%) Query: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT Sbjct: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60 Query: 61 VRKICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKY 120 VRKICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKY Sbjct: 61 VRKICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKY 120 Query: 121 TQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTE 180 TQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTE Sbjct: 121 TQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTE 180 Query: 181 DAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEE 240 DAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEE Sbjct: 181 DAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEE 240 Query: 241 AEKKKSKKSV 250 AEKKKSKKSV Sbjct: 241 AEKKKSKKSV 250 >gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens] Length = 256 Score = 479 bits (1232), Expect = e-135 Identities = 250/256 (97%), Positives = 250/256 (97%), Gaps = 6/256 (2%) Query: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT Sbjct: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60 Query: 61 VRKICALDDHVCMAFA------GLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA 114 VRKICALDDHVCMAFA GLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA Sbjct: 61 VRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA 120 Query: 115 TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL 174 TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL Sbjct: 121 TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL 180 Query: 175 EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI 234 EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI Sbjct: 181 EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI 240 Query: 235 EKEKEEAEKKKSKKSV 250 EKEKEEAEKKKSKKSV Sbjct: 241 EKEKEEAEKKKSKKSV 256 >gi|4506189 proteasome alpha 7 subunit [Homo sapiens] Length = 248 Score = 416 bits (1068), Expect = e-116 Identities = 208/245 (84%), Positives = 228/245 (93%) Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKI 64 YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVG+RG +IVVLGVEKKSVAKLQDERTVRKI Sbjct: 3 YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKI 62 Query: 65 CALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSN 124 CALDD+VCMAFAGLTADAR+VINRARVECQSH+LTVEDPVTVEYITR+IA+LKQ+YTQSN Sbjct: 63 CALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSN 122 Query: 125 GRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIA 184 GRRPFGISALIVGFD DG RLYQTDPSGTYHAWKANAIGR AK+VREFLEKNYT++AI Sbjct: 123 GRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIE 182 Query: 185 SDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEEAEKK 244 +D IKL IKALLEVVQSGGKNIELA++RR+Q LK+ + +E+E YV EIEKEKEE EKK Sbjct: 183 TDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENEKK 242 Query: 245 KSKKS 249 K KK+ Sbjct: 243 KQKKA 247 >gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens] Length = 212 Score = 392 bits (1008), Expect = e-109 Identities = 212/250 (84%), Positives = 212/250 (84%), Gaps = 38/250 (15%) Query: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRG Sbjct: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRG--------------------- 39 Query: 61 VRKICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKY 120 LTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKY Sbjct: 40 -----------------LTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKY 82 Query: 121 TQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTE 180 TQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTE Sbjct: 83 TQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTE 142 Query: 181 DAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEE 240 DAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEE Sbjct: 143 DAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEE 202 Query: 241 AEKKKSKKSV 250 AEKKKSKKSV Sbjct: 203 AEKKKSKKSV 212 >gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens] Length = 261 Score = 169 bits (427), Expect = 3e-42 Identities = 93/255 (36%), Positives = 151/255 (59%), Gaps = 8/255 (3%) Query: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60 M+ RYD T+FSP+G L+QVEYA EA+ T +GI + V+L E++++ KL DE Sbjct: 1 MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVF 60 Query: 61 V-RKICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQK 119 KI L++ + + AG+T+DA V+ N R+ Q + L ++P+ E + + +KQ Sbjct: 61 FSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQA 120 Query: 120 YTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYT 179 YTQ G+RPFG+S L +G+D +LYQ+DPSG Y WKA IG ++ L+++Y Sbjct: 121 YTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYK 180 Query: 180 EDAIASDSEAIKLAIKAL---LEVVQSGGKNIELAIIRRNQ---PLKMFSAKEVELYVTE 233 E + S A+ LAIK L ++V + + +E+A + R +++ KEVE + + Sbjct: 181 EGEMTLKS-ALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKK 239 Query: 234 IEKEKEEAEKKKSKK 248 E+E+ +AE++K +K Sbjct: 240 HEEEEAKAEREKKEK 254 >gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens] Length = 261 Score = 169 bits (427), Expect = 3e-42 Identities = 93/255 (36%), Positives = 151/255 (59%), Gaps = 8/255 (3%) Query: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60 M+ RYD T+FSP+G L+QVEYA EA+ T +GI + V+L E++++ KL DE Sbjct: 1 MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVF 60 Query: 61 V-RKICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQK 119 KI L++ + + AG+T+DA V+ N R+ Q + L ++P+ E + + +KQ Sbjct: 61 FSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQA 120 Query: 120 YTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYT 179 YTQ G+RPFG+S L +G+D +LYQ+DPSG Y WKA IG ++ L+++Y Sbjct: 121 YTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYK 180 Query: 180 EDAIASDSEAIKLAIKAL---LEVVQSGGKNIELAIIRRNQ---PLKMFSAKEVELYVTE 233 E + S A+ LAIK L ++V + + +E+A + R +++ KEVE + + Sbjct: 181 EGEMTLKS-ALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKK 239 Query: 234 IEKEKEEAEKKKSKK 248 E+E+ +AE++K +K Sbjct: 240 HEEEEAKAEREKKEK 254 >gi|4506181 proteasome subunit alpha type 2 [Homo sapiens] Length = 234 Score = 159 bits (401), Expect = 3e-39 Identities = 96/237 (40%), Positives = 139/237 (58%), Gaps = 7/237 (2%) Query: 1 MASR-YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDER 59 MA R Y ++T FSP G L Q+EYA AV G+ +VGI+ N VVL EKK + L DER Sbjct: 1 MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER 60 Query: 60 TVRKICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQK 119 +V K+ + H+ + ++G+ D RV+++RAR Q + L ++P+ + + +A++ Q+ Sbjct: 61 SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE 120 Query: 120 YTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYT 179 YTQS G RPFG+S LI G+ ++G L+Q+DPSG Y AWKA A+G++ + FLEK Y Sbjct: 121 YTQSGGVRPFGVSLLICGW-NEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYN 179 Query: 180 EDAIASDSEAIKLAIKALLEVV--QSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI 234 ED D AI AI L E Q NIE+ I + + EV+ Y+ I Sbjct: 180 EDLELED--AIHTAILTLKESFEGQMTEDNIEVGIC-NEAGFRRLTPTEVKDYLAAI 233 >gi|23110942 proteasome alpha 5 subunit [Homo sapiens] Length = 241 Score = 157 bits (398), Expect = 6e-39 Identities = 90/239 (37%), Positives = 144/239 (60%), Gaps = 10/239 (4%) Query: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVR 62 S YDR + FSP+G LFQVEYA EA+K GSTA+GI+ + V L VEK+ + L + ++ Sbjct: 6 SEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIE 65 Query: 63 KICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQ 122 KI +D H+ A +GL ADA+ +I++ARVE Q+H T + +TVE +T+ ++ L ++ + Sbjct: 66 KIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGE 125 Query: 123 SNG-----RRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKN 177 + RPFG++ L G D+ G +L+ DPSGT+ A AIG +++ + L++ Sbjct: 126 EDADPGAMSRPFGVALLFGGVDEKG-PQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEV 184 Query: 178 YTEDAIASDSEAIKLAIKALLEVVQS--GGKNIELAIIRRNQPLKMFSAKEVELYVTEI 234 Y + EAIK ++ L +V++ NIELA ++ Q MF+ +E+E + +I Sbjct: 185 YHKSMTL--KEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI 241 >gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens] Length = 263 Score = 141 bits (355), Expect = 6e-34 Identities = 78/241 (32%), Positives = 139/241 (57%), Gaps = 7/241 (2%) Query: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVR 62 ++YD +TV+SP G + Q+EYA EAVK+GS VG++ VL K++ ++L + + Sbjct: 4 NQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ--K 61 Query: 63 KICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQ 122 KI +D+H+ ++ AGLTADAR++ N R EC + + P+ V + I + Q TQ Sbjct: 62 KILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQ 121 Query: 123 SNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDA 182 GRRP+G+ LI G+DD G ++QT PS Y +A +IG +++ R +LE++ +E Sbjct: 122 RYGRRPYGVGLLIAGYDDMG-PHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM 180 Query: 183 IASDSEAIKLAIKALLEVVQS----GGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEK 238 + +E +K ++AL E + + KN+ + I+ ++ ++ +V ++ +E+ Sbjct: 181 ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP 240 Query: 239 E 239 + Sbjct: 241 Q 241 >gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens] Length = 269 Score = 141 bits (355), Expect = 6e-34 Identities = 78/241 (32%), Positives = 139/241 (57%), Gaps = 7/241 (2%) Query: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVR 62 ++YD +TV+SP G + Q+EYA EAVK+GS VG++ VL K++ ++L + + Sbjct: 10 NQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ--K 67 Query: 63 KICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQ 122 KI +D+H+ ++ AGLTADAR++ N R EC + + P+ V + I + Q TQ Sbjct: 68 KILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQ 127 Query: 123 SNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDA 182 GRRP+G+ LI G+DD G ++QT PS Y +A +IG +++ R +LE++ +E Sbjct: 128 RYGRRPYGVGLLIAGYDDMG-PHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM 186 Query: 183 IASDSEAIKLAIKALLEVVQS----GGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEK 238 + +E +K ++AL E + + KN+ + I+ ++ ++ +V ++ +E+ Sbjct: 187 ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP 246 Query: 239 E 239 + Sbjct: 247 Q 247 >gi|23110944 proteasome alpha 6 subunit [Homo sapiens] Length = 246 Score = 124 bits (312), Expect = 6e-29 Identities = 72/234 (30%), Positives = 126/234 (53%), Gaps = 4/234 (1%) Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGS-TAVGIRGTNIVVLGVEKKSVAKLQDERTVRK 63 +DR IT+FSP+G L+QVEYA +A+ +G T+V +RG + V+ +KK KL D TV Sbjct: 9 FDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTH 68 Query: 64 ICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQS 123 + + +++ G+TAD+R + RAR E + K + V+ + + IA + Q YTQ+ Sbjct: 69 LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQN 128 Query: 124 NGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAI 183 RP G +++G D++ ++Y+ DP+G Y +KA A G FLEK + Sbjct: 129 AEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFD 188 Query: 184 ASDSEAIKLAIKALLEVVQSGGK--NIELAIIR-RNQPLKMFSAKEVELYVTEI 234 + + ++ AI L V+ K IE+ ++ N ++ + E++ ++ + Sbjct: 189 WTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVAL 242 >gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens] Length = 255 Score = 122 bits (305), Expect = 4e-28 Identities = 79/245 (32%), Positives = 135/245 (55%), Gaps = 8/245 (3%) Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKI 64 YD + + FSPDG +FQVEYA +AV+ STA+GIR + VV GVEK ++KL +E + +++ Sbjct: 8 YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67 Query: 65 CALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSN 124 +D HV MA AGL ADAR + + AR E + + + ++++ +A YT + Sbjct: 68 FNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYS 127 Query: 125 GRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIA 184 RPFG S ++ + + ++LY DPSG + + AIG++ + + +EK ++ Sbjct: 128 AVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTC 187 Query: 185 SD--SEAIKLAIKALLEVVQSGGKNIELAII-----RRNQPLKMFSAKEVELYVTEIEKE 237 D E K+ I + + V+ +EL+ + R++ + +E E Y E KE Sbjct: 188 RDIVKEVAKI-IYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKE 246 Query: 238 KEEAE 242 ++E++ Sbjct: 247 EDESD 251 >gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens] Length = 248 Score = 117 bits (294), Expect = 7e-27 Identities = 81/245 (33%), Positives = 134/245 (54%), Gaps = 15/245 (6%) Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKI 64 YD + + FSPDG +FQVEYA +AV+ STA+GIR + VV GVEK ++KL +E + +++ Sbjct: 8 YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67 Query: 65 CALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSN 124 +D HV MA AGL ADAR + + AR E + + + ++++ +A YT + Sbjct: 68 FNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYS 127 Query: 125 GRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIA 184 RPFG S +DG ++LY DPSG + + AIG++ + + +EK ++ Sbjct: 128 AVRPFGCSV------NDG-AQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTC 180 Query: 185 SD--SEAIKLAIKALLEVVQSGGKNIELAII-----RRNQPLKMFSAKEVELYVTEIEKE 237 D E K+ I + + V+ +EL+ + R++ + +E E Y E KE Sbjct: 181 RDIVKEVAKI-IYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKE 239 Query: 238 KEEAE 242 ++E++ Sbjct: 240 EDESD 244 >gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens] Length = 190 Score = 116 bits (290), Expect = 2e-26 Identities = 63/179 (35%), Positives = 105/179 (58%), Gaps = 7/179 (3%) Query: 76 AGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALI 135 AG+T+DA V+ N R+ Q + L ++P+ E + + +KQ YTQ G+RPFG+S L Sbjct: 6 AGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLY 65 Query: 136 VGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIASDSEAIKLAIK 195 +G+D +LYQ+DPSG Y WKA IG ++ L+++Y E + S A+ LAIK Sbjct: 66 IGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKS-ALALAIK 124 Query: 196 AL---LEVVQSGGKNIELAIIRRNQ---PLKMFSAKEVELYVTEIEKEKEEAEKKKSKK 248 L ++V + + +E+A + R +++ KEVE + + E+E+ +AE++K +K Sbjct: 125 VLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEK 183 >gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens] Length = 130 Score = 82.8 bits (203), Expect = 3e-16 Identities = 42/113 (37%), Positives = 69/113 (61%), Gaps = 2/113 (1%) Query: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVR 62 ++YD +TV+SP G + Q+EYA EAVK+GS VG++ VL K++ ++L + + Sbjct: 4 NQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ--K 61 Query: 63 KICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIAT 115 KI +D+H+ ++ AGLTADAR++ N R EC + + P+ V + I + Sbjct: 62 KILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGS 114 >gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens] Length = 272 Score = 48.5 bits (114), Expect = 5e-06 Identities = 44/172 (25%), Positives = 71/172 (41%), Gaps = 41/172 (23%) Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGS-TAVGIRGTNIVVLGVEKKSVAKLQDERTVRK 63 +DR + +FSP L+QV+YA +A+ +G T+V +R + V+ K KL D RT Sbjct: 93 FDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSRT--H 150 Query: 64 ICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQS 123 + + + G+TAD+R RA+ + + K + Sbjct: 151 LFKMTKNTGRVITGVTADSRSREQRAQYKAANCKYNI----------------------- 187 Query: 124 NGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLE 175 F++ G R+Y+ D +G Y +KA A G FLE Sbjct: 188 --------------FEELG-PRVYKCDAAGYYCGFKATAAGVKQAESTSFLE 224 >gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens] Length = 272 Score = 48.5 bits (114), Expect = 5e-06 Identities = 44/172 (25%), Positives = 71/172 (41%), Gaps = 41/172 (23%) Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGS-TAVGIRGTNIVVLGVEKKSVAKLQDERTVRK 63 +DR + +FSP L+QV+YA +A+ +G T+V +R + V+ K KL D RT Sbjct: 93 FDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSRT--H 150 Query: 64 ICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQS 123 + + + G+TAD+R RA+ + + K + Sbjct: 151 LFKMTKNTGRVITGVTADSRSREQRAQYKAANCKYNI----------------------- 187 Query: 124 NGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLE 175 F++ G R+Y+ D +G Y +KA A G FLE Sbjct: 188 --------------FEELG-PRVYKCDAAGYYCGFKATAAGVKQAESTSFLE 224 >gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens] Length = 272 Score = 48.5 bits (114), Expect = 5e-06 Identities = 44/172 (25%), Positives = 71/172 (41%), Gaps = 41/172 (23%) Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGS-TAVGIRGTNIVVLGVEKKSVAKLQDERTVRK 63 +DR + +FSP L+QV+YA +A+ +G T+V +R + V+ K KL D RT Sbjct: 93 FDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSRT--H 150 Query: 64 ICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQS 123 + + + G+TAD+R RA+ + + K + Sbjct: 151 LFKMTKNTGRVITGVTADSRSREQRAQYKAANCKYNI----------------------- 187 Query: 124 NGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLE 175 F++ G R+Y+ D +G Y +KA A G FLE Sbjct: 188 --------------FEELG-PRVYKCDAAGYYCGFKATAAGVKQAESTSFLE 224 >gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens] Length = 273 Score = 43.1 bits (100), Expect = 2e-04 Identities = 43/192 (22%), Positives = 80/192 (41%), Gaps = 10/192 (5%) Query: 27 AVKKGSTAVGIRGTNIVVLGVEKKSVA-KLQDERTVRKICALDDHVCMAFAGLTADARVV 85 A K G+T G+ + V+LG + ++ + +++ KI + + AG+ ADA + Sbjct: 35 ARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMT 94 Query: 86 INRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGISR 145 + + H L+ V +TR + +Y G ++LIVG D + Sbjct: 95 TRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVG------ASLIVGGVDLTGPQ 148 Query: 146 LYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAI--ASDSEAIKLAIKALLEVVQS 203 LY P G+Y A+G LE + + A+ ++ +L + S Sbjct: 149 LYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGS 208 Query: 204 GGKNIELAIIRR 215 GG N++ +I + Sbjct: 209 GG-NVDACVITK 219 >gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo sapiens] Length = 209 Score = 40.8 bits (94), Expect = 0.001 Identities = 28/123 (22%), Positives = 53/123 (43%), Gaps = 6/123 (4%) Query: 28 VKKGSTAVGIRGTNIVVLGVEKK-SVAKLQDERTVRKICALDDHVCMAFAGLTADARVVI 86 V G+T + + VV+G + + S + R K+ L + + A +G ADA+ V Sbjct: 7 VHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVA 66 Query: 87 NRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGISRL 146 + A + + H + +E+P V + + KY R ++ G+D ++ Sbjct: 67 DMAAYQLELHGIELEEPPLVLAAANVVRNISYKY-----REDLSAHLMVAGWDQREGGQV 121 Query: 147 YQT 149 Y T Sbjct: 122 YGT 124 >gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo sapiens] Length = 219 Score = 40.8 bits (94), Expect = 0.001 Identities = 28/123 (22%), Positives = 53/123 (43%), Gaps = 6/123 (4%) Query: 28 VKKGSTAVGIRGTNIVVLGVEKK-SVAKLQDERTVRKICALDDHVCMAFAGLTADARVVI 86 V G+T + + VV+G + + S + R K+ L + + A +G ADA+ V Sbjct: 17 VHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVA 76 Query: 87 NRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGISRL 146 + A + + H + +E+P V + + KY R ++ G+D ++ Sbjct: 77 DMAAYQLELHGIELEEPPLVLAAANVVRNISYKY-----REDLSAHLMVAGWDQREGGQV 131 Query: 147 YQT 149 Y T Sbjct: 132 YGT 134 >gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens] Length = 263 Score = 36.6 bits (83), Expect = 0.021 Identities = 38/205 (18%), Positives = 90/205 (43%), Gaps = 13/205 (6%) Query: 31 GSTAVGIRGTNIVVLGVEKKSVAKLQ-DERTVRKICALDDHVCMAFAGLTADARVVINRA 89 G+T + + + V++ + ++ A +TV+K+ ++ ++ AG AD Sbjct: 59 GTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLL 118 Query: 90 RVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQT 149 +C+ ++L ++ ++V ++ +A + +Y + +I G+D G LY Sbjct: 119 ARQCRIYELRNKERISVAAASKLLANMVYQYKGMG----LSMGTMICGWDKRG-PGLYYV 173 Query: 150 DPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIASDSEAIKLAIKALLEV----VQSGG 205 D G + ++G + +++ Y+ D +A LA +A+ + SGG Sbjct: 174 DSEGNRISGATFSVGSGSVYAYGVMDRGYSYD--LEVEQAYDLARRAIYQATYRDAYSGG 231 Query: 206 KNIELAIIRRNQPLKMFSAKEVELY 230 + L +R + +++ S +L+ Sbjct: 232 A-VNLYHVREDGWIRVSSDNVADLH 255 >gi|70980531 GGA binding partner [Homo sapiens] Length = 441 Score = 34.3 bits (77), Expect = 0.10 Identities = 25/77 (32%), Positives = 45/77 (58%), Gaps = 2/77 (2%) Query: 175 EKNYTEDAIASDSEAIKLAIK-ALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTE 233 E+ ++A+ S ++ K A+K A+L+VV+ KN+E A + K AK+ E E Sbjct: 295 ERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQE 354 Query: 234 IEKEKEEAEKKKSKKSV 250 I+K +E ++K S+++V Sbjct: 355 IQKAIQE-QRKISQETV 370 >gi|4506193 proteasome beta 1 subunit [Homo sapiens] Length = 241 Score = 33.1 bits (74), Expect = 0.23 Identities = 30/149 (20%), Positives = 58/149 (38%), Gaps = 5/149 (3%) Query: 28 VKKGSTAVGIRGTNIVVLGVEKK-SVAKLQDERTVRKICALDDHVCMAFAGLTADARVVI 86 V G T + I G + ++ + + S R K L D + +G D + Sbjct: 34 VFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLT 93 Query: 87 NRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGISRL 146 + +K + +T I ++T+ S P+ + +I G D++G + Sbjct: 94 KIIEARLKMYKHSNNKAMTTGAIAAMLSTI----LYSRRFFPYYVYNIIGGLDEEGKGAV 149 Query: 147 YQTDPSGTYHAWKANAIGRSAKTVREFLE 175 Y DP G+Y A G ++ ++ L+ Sbjct: 150 YSFDPVGSYQRDSFKAGGSASAMLQPLLD 178 >gi|222144262 proteasome beta 5 subunit isoform 3 [Homo sapiens] Length = 203 Score = 29.3 bits (64), Expect = 3.4 Identities = 20/113 (17%), Positives = 52/113 (46%), Gaps = 5/113 (4%) Query: 31 GSTAVGIRGTNIVVLGVEKKSVAKLQ-DERTVRKICALDDHVCMAFAGLTADARVVINRA 89 G+T + + + V++ + ++ A +TV+K+ ++ ++ AG AD Sbjct: 59 GTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLL 118 Query: 90 RVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDG 142 +C+ ++L ++ ++V ++ +A + +Y + +I G+D G Sbjct: 119 ARQCRIYELRNKERISVAAASKLLANMVYQYKGMG----LSMGTMICGWDKRG 167 >gi|102467242 inner centromere protein antigens 135/155kDa isoform 2 [Homo sapiens] Length = 914 Score = 29.3 bits (64), Expect = 3.4 Identities = 18/52 (34%), Positives = 29/52 (55%), Gaps = 1/52 (1%) Query: 197 LLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEEAEKKKSKK 248 +L S +++ + I+RN PL+M KE E E + KEEAE+ + +K Sbjct: 504 MLMTPTSAPRSVMKSFIKRNTPLRM-DPKEKERQRLENLRRKEEAEQLRRQK 554 >gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] Length = 1684 Score = 28.9 bits (63), Expect = 4.4 Identities = 20/63 (31%), Positives = 33/63 (52%), Gaps = 11/63 (17%) Query: 194 IKALLEVVQSGGKNIELAIIR---------RNQPLKMFSAKEVELYVTEIEKEKEEAEKK 244 +K LLE + + EL +++ +N PL S KE+E + +EKE +E E+K Sbjct: 909 LKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLS--SVKELEEKIENLEKECKEKEEK 966 Query: 245 KSK 247 +K Sbjct: 967 INK 969 >gi|109255234 centrosomal protein 290kDa [Homo sapiens] Length = 2479 Score = 28.5 bits (62), Expect = 5.8 Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 1/59 (1%) Query: 185 SDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEEAEK 243 +D+ I L+ + E+ +N+ + + R Q L A+EVEL + E+EK EE K Sbjct: 25 ADNLLISLSKVEVNELKSEKQENV-IHLFRITQSLMKMKAQEVELALEEVEKAGEEQAK 82 >gi|4506411 Ran GTPase activating protein 1 [Homo sapiens] Length = 587 Score = 28.5 bits (62), Expect = 5.8 Identities = 35/134 (26%), Positives = 59/134 (44%), Gaps = 14/134 (10%) Query: 111 RFIATLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTV 170 R I TL++ + NG GI+AL F + + R+ + T+ A A+ + KT+ Sbjct: 205 RVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLN-DNTFTEKGAVAMAETLKTL 263 Query: 171 REFLEKNYTEDAIAS-DSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVEL 229 R+ N+ + + S + AI AI+ L ++ N+ I+R + L Sbjct: 264 RQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKE--LNLSFCEIKR----------DAAL 311 Query: 230 YVTEIEKEKEEAEK 243 V E +K E EK Sbjct: 312 AVAEAMADKAELEK 325 >gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] Length = 1356 Score = 28.1 bits (61), Expect = 7.5 Identities = 18/81 (22%), Positives = 42/81 (51%), Gaps = 1/81 (1%) Query: 168 KTVREFLEKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPL-KMFSAKE 226 ++ R ++K+Y + A+ D E ++ + E +SG +++ A + + L + + + Sbjct: 923 ESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERQMNGNQ 982 Query: 227 VELYVTEIEKEKEEAEKKKSK 247 + T+ +K+K EKKK + Sbjct: 983 EKGDKTDRKKDKTGKEKKKDR 1003 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.131 0.358 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 7,999,404 Number of Sequences: 37866 Number of extensions: 311462 Number of successful extensions: 1535 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 23 Number of HSP's successfully gapped in prelim test: 15 Number of HSP's that attempted gapping in prelim test: 1478 Number of HSP's gapped (non-prelim): 54 length of query: 250 length of database: 18,247,518 effective HSP length: 100 effective length of query: 150 effective length of database: 14,460,918 effective search space: 2169137700 effective search space used: 2169137700 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.