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Search of human proteins with 66392157
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66392157 RGD motif, leucine rich repeats, tropomodulin
domain and proline-rich containing [Homo sapiens]
(1435 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|66392157 RGD motif, leucine rich repeats, tropomodulin domain... 2875 0.0
gi|156938257 leucine rich repeat containing 16B [Homo sapiens] 733 0.0
gi|63054866 leucine rich repeat containing 16A [Homo sapiens] 615 e-176
gi|118918429 NOD3 protein [Homo sapiens] 108 3e-23
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 78 5e-14
gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens] 64 1e-09
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 64 1e-09
gi|163965366 nascent polypeptide-associated complex alpha subuni... 64 1e-09
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 62 5e-09
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 60 2e-08
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 59 3e-08
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 58 7e-08
gi|112734870 hypothetical protein LOC57648 [Homo sapiens] 58 7e-08
gi|153792074 proline rich 12 [Homo sapiens] 58 7e-08
gi|25777608 NLR family member X1 isoform 1 [Homo sapiens] 57 1e-07
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 56 2e-07
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 56 2e-07
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 55 5e-07
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 55 6e-07
gi|149158690 HLA-B associated transcript-2 [Homo sapiens] 55 6e-07
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 55 6e-07
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 54 1e-06
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho... 54 1e-06
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 54 1e-06
gi|168986655 hypothetical protein LOC145497 [Homo sapiens] 54 1e-06
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 53 2e-06
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 53 2e-06
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 53 2e-06
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 53 2e-06
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 53 2e-06
>gi|66392157 RGD motif, leucine rich repeats, tropomodulin domain and
proline-rich containing [Homo sapiens]
Length = 1435
Score = 2875 bits (7452), Expect = 0.0
Identities = 1435/1435 (100%), Positives = 1435/1435 (100%)
Query: 1 MAQTPDGISCELRGEITRFLWPKEVELLLKTWLPGEGAVQNHVLALLRWRAYLLHTTCLP 60
MAQTPDGISCELRGEITRFLWPKEVELLLKTWLPGEGAVQNHVLALLRWRAYLLHTTCLP
Sbjct: 1 MAQTPDGISCELRGEITRFLWPKEVELLLKTWLPGEGAVQNHVLALLRWRAYLLHTTCLP 60
Query: 61 LRVDCTFSYLEVQAMALQETPPQVTFELESLRELVLEFPGVAALEQLAQHVAAAIKKVFP 120
LRVDCTFSYLEVQAMALQETPPQVTFELESLRELVLEFPGVAALEQLAQHVAAAIKKVFP
Sbjct: 61 LRVDCTFSYLEVQAMALQETPPQVTFELESLRELVLEFPGVAALEQLAQHVAAAIKKVFP 120
Query: 121 RSTLGKLFRRPTPASMLARLERSSPSESTDPCSPCGGFLETYEALCDYNGFPFREEIQWD 180
RSTLGKLFRRPTPASMLARLERSSPSESTDPCSPCGGFLETYEALCDYNGFPFREEIQWD
Sbjct: 121 RSTLGKLFRRPTPASMLARLERSSPSESTDPCSPCGGFLETYEALCDYNGFPFREEIQWD 180
Query: 181 VDTIYHRQGCRHFSLGDFSHLGSRDLALSVAALSYNLWFRCLSCVDMKLSLEVSEQILHM 240
VDTIYHRQGCRHFSLGDFSHLGSRDLALSVAALSYNLWFRCLSCVDMKLSLEVSEQILHM
Sbjct: 181 VDTIYHRQGCRHFSLGDFSHLGSRDLALSVAALSYNLWFRCLSCVDMKLSLEVSEQILHM 240
Query: 241 MSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLE 300
MSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLE
Sbjct: 241 MSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLE 300
Query: 301 RCPGALRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNPGALGASEDSGGLY 360
RCPGALRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNPGALGASEDSGGLY
Sbjct: 301 RCPGALRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNPGALGASEDSGGLY 360
Query: 361 SFLSRPNVLSFLNLAGTDTALDTVRGCSVGGWMTGRADWRAGRGGLGPPAGVANSLPPQL 420
SFLSRPNVLSFLNLAGTDTALDTVRGCSVGGWMTGRADWRAGRGGLGPPAGVANSLPPQL
Sbjct: 361 SFLSRPNVLSFLNLAGTDTALDTVRGCSVGGWMTGRADWRAGRGGLGPPAGVANSLPPQL 420
Query: 421 FAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDALR 480
FAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDALR
Sbjct: 421 FAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDALR 480
Query: 481 ALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGAVSSLDLADNGFGSDMVTLV 540
ALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGAVSSLDLADNGFGSDMVTLV
Sbjct: 481 ALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGAVSSLDLADNGFGSDMVTLV 540
Query: 541 LAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRLKLGASV 600
LAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRLKLGASV
Sbjct: 541 LAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRLKLGASV 600
Query: 601 LLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLRSVVWDRNHTSALGLLDVAQA 660
LLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLRSVVWDRNHTSALGLLDVAQA
Sbjct: 601 LLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLRSVVWDRNHTSALGLLDVAQA 660
Query: 661 LEQNHSLKAMPLPLNDVAQAQRSRPELTARAVHQIQACLLRNNRADPASSDHTTRLQPLG 720
LEQNHSLKAMPLPLNDVAQAQRSRPELTARAVHQIQACLLRNNRADPASSDHTTRLQPLG
Sbjct: 661 LEQNHSLKAMPLPLNDVAQAQRSRPELTARAVHQIQACLLRNNRADPASSDHTTRLQPLG 720
Query: 721 LVSDPSEQEVNELCQSVQEHVELLGCGAGPQGEAAVRQAEDAIQNANFSLSILPILYEAG 780
LVSDPSEQEVNELCQSVQEHVELLGCGAGPQGEAAVRQAEDAIQNANFSLSILPILYEAG
Sbjct: 721 LVSDPSEQEVNELCQSVQEHVELLGCGAGPQGEAAVRQAEDAIQNANFSLSILPILYEAG 780
Query: 781 SSPSHHWQLGQKLEGLLRQVGEVCRQDIQDFTQATLDTARSLCPQMLQGSSWREQLEGVL 840
SSPSHHWQLGQKLEGLLRQVGEVCRQDIQDFTQATLDTARSLCPQMLQGSSWREQLEGVL
Sbjct: 781 SSPSHHWQLGQKLEGLLRQVGEVCRQDIQDFTQATLDTARSLCPQMLQGSSWREQLEGVL 840
Query: 841 AGSRGLPELLPEQLLQDAFTRLRDMRLSITGTLAESIVAQALAGLSAARDQLVESLAQQA 900
AGSRGLPELLPEQLLQDAFTRLRDMRLSITGTLAESIVAQALAGLSAARDQLVESLAQQA
Sbjct: 841 AGSRGLPELLPEQLLQDAFTRLRDMRLSITGTLAESIVAQALAGLSAARDQLVESLAQQA 900
Query: 901 TVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFI 960
TVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFI
Sbjct: 901 TVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFI 960
Query: 961 HSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPT 1020
HSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPT
Sbjct: 961 HSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPT 1020
Query: 1021 RARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEED 1080
RARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEED
Sbjct: 1021 RARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEED 1080
Query: 1081 PATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPT 1140
PATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPT
Sbjct: 1081 PATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPT 1140
Query: 1141 RPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLER 1200
RPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLER
Sbjct: 1141 RPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLER 1200
Query: 1201 GETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPI 1260
GETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPI
Sbjct: 1201 GETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPI 1260
Query: 1261 SIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSP 1320
SIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSP
Sbjct: 1261 SIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSP 1320
Query: 1321 SPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQR 1380
SPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQR
Sbjct: 1321 SPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQR 1380
Query: 1381 SPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPSPATDQRGGGPNP 1435
SPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPSPATDQRGGGPNP
Sbjct: 1381 SPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPSPATDQRGGGPNP 1435
>gi|156938257 leucine rich repeat containing 16B [Homo sapiens]
Length = 1372
Score = 733 bits (1893), Expect = 0.0
Identities = 524/1442 (36%), Positives = 748/1442 (51%), Gaps = 162/1442 (11%)
Query: 40 QNHVLALLRWRAYLLHTTCLPLRVDCTFSYLEVQAMALQETPPQVTFELESLRELV-LEF 98
++ VLAL WR +L +P +V+ +F+ LE++A T Q +E+ R +V +
Sbjct: 41 EDRVLALTSWRLHLFLLK-VPAKVESSFNVLEIRAF---NTLSQNQILVETERGMVSMRL 96
Query: 99 PGVAALEQLAQHVAAAIKKVFPRSTLGKLFRR---PTPASMLARLERSSPSESTDPCSPC 155
P +++Q+ +HV++A+ KV P G L RR TP S S ST S C
Sbjct: 97 PSAESVDQVTRHVSSALSKVCPGP--GCLIRRGNADTPEGPRDTSPNSETSTSTTH-SVC 153
Query: 156 GGFLETYEALCDYNGFPFREEIQWDVDTIYHRQGCRHFSLGDFSHLGSRDLALSVAALSY 215
GGF ETY ALCDYNG REE+QWDVDTIYH + R F+L DFSHL SRDLAL VAAL+Y
Sbjct: 154 GGFSETYAALCDYNGLHCREEVQWDVDTIYHAEDNREFNLLDFSHLESRDLALMVAALAY 213
Query: 216 NLWFRCLSCVDMKLSLEVSEQILHMMSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSS 275
N WF L C D++L EV EQ+LH +S+S LEELVL+ L+ DFV++LA + S
Sbjct: 214 NQWFTKLYCKDLRLGSEVLEQVLHTLSKSGSLEELVLDNAGLKTDFVQKLAGVFGENGSC 273
Query: 276 GLRELSLAGNLLDDRGMTALSRHLERCPGALRRLSLAQTGLTPRGMRALGRALATNAAFD 335
L L+L+ N ++D+G +LS+ L P L +L LA+T ++PRG++ALG+ N AF
Sbjct: 274 VLHALTLSHNPIEDKGFLSLSQQLLCFPSGLTKLCLAKTAISPRGLQALGQTFGANPAFA 333
Query: 336 STLTHLDLSGNPGALGASEDSGGLYSFLSRPNVLSFLNLAGTDTALDTVRGCSVGGWMTG 395
S+L +LDLS NPG L A++++ LYSFL++PN L L+L+GTD +D + G
Sbjct: 334 SSLRYLDLSKNPGLL-ATDEANALYSFLAQPNALVHLDLSGTDCVIDLLLG--------- 383
Query: 396 RADWRAGRGGLGPPAGVANSLPPQLFAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQ 455
A+ GCC+ LT+L+ +RN S K R AP A +
Sbjct: 384 ---------------------------ALLHGCCSHLTYLNLARNSCSHRKGREAPPAFK 416
Query: 456 LFLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDL 515
F S A TL H+ L+ KLP +ALRALL GL+LN+HL DLHLDLS+CELRSAGAQ +Q+
Sbjct: 417 QFFSSAYTLSHVNLSATKLPLEALRALLQGLSLNSHLSDLHLDLSSCELRSAGAQALQEQ 476
Query: 516 VCDAGAVSSLDLADNGFGSDMVTLVLAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQ 575
+ V SLDL+DNGF SD++TLV A+G+++SL+H+ LG+NFNV+ K TL+++LH++VQ
Sbjct: 477 LGAVTCVGSLDLSDNGFDSDLLTLVPALGKNKSLKHLFLGKNFNVKAK-TLEEILHKLVQ 535
Query: 576 LMQDDDCPLQSLSVAESRLKLGASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRV 635
L+Q++DC LQSLSVA+SRLKL S+L+ AL +N L +D+SGN M D GAK+L+KAL++
Sbjct: 536 LIQEEDCSLQSLSVADSRLKLRTSILINALGSNTCLAKVDLSGNGMEDIGAKMLSKALQI 595
Query: 636 NSRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLNDVAQAQRSRPELTARAVHQI 695
NS LR+++WDRN+TSALG LD+A+ALE NH+L+ M P++D++QA RS PE T +I
Sbjct: 596 NSSLRTILWDRNNTSALGFLDIARALESNHTLRFMSFPVSDISQAYRSAPERTEDVWQKI 655
Query: 696 QACLLRNNRADPASSDHTTRLQPLGLVSDPSEQEVNELCQSVQEHVELLGCGAGPQGEAA 755
Q CL+RNN + + RLQ GLV+ +EQ + LC VQE V L +
Sbjct: 656 QWCLVRNNHSQTCPQEQAFRLQQ-GLVTSSAEQMLQRLCGRVQEEVRALRLCPLEPVQDE 714
Query: 756 VRQAEDAIQNANFSLSILPILYEAGSSPSHHWQLGQKLEGLLRQVGEVCRQDIQDFTQAT 815
+ A D I++A S ++ P LYE G ++ + Q+LE + +V + +++Q ++
Sbjct: 715 LLYARDLIKDAKNSRALFPSLYELGHVLANDGPVRQRLESVASEVSKAVDKELQVILESM 774
Query: 816 LDTARSLCPQMLQGSSWREQLEGVLAGSRGLPE-----LLPEQLLQDAFTRLRDMRLSIT 870
+ + LCP ++ + ++ +A +P L EQ QD +L +++LS+
Sbjct: 775 VSLTQELCPVAMRVAEGHNKMLSNVAERVTVPRNFIRGALLEQAGQDIQNKLDEVKLSVV 834
Query: 871 GTLAESIVAQALAGLSAARDQLVESLAQQATVTMPPALPAPDGGEPSLLEPGELEGLFFP 930
L SIV + L L + L L Q T++ PP P G L G
Sbjct: 835 TYLTSSIVDEILQELYHSHKSLARHLTQLRTLSDPPGCP---GQGQDLSSRGRGRNHDHE 891
Query: 931 EEKEEEKEKD-DSPPQKWPELSHGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSAR 989
E ++E + D+ K + + V SA P+ + G P S
Sbjct: 892 ETTDDELGTNIDTMAIKKQKRCRKIRPV----SAFISGSPQDMESQLGNLGIPPGWFSGL 947
Query: 990 GSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEG 1049
G P A G G +LP G LRH T+ RPRP R P PG P +P ++
Sbjct: 948 GGSQPTASGSWEG---LSELPTHGYKLRHQTQGRPRPPRT--TPPGPGRPSMPAPGTRQE 1002
Query: 1050 NGLSARVDEGVEEFFSKRLIQQDRLWAPEEDPATEG-GATPVPRTLRKKLGTLFAFKKPR 1108
NG++ R+DEG+E+FFS+R++++ + G P+P +K+ LF F++PR
Sbjct: 1003 NGMATRLDEGLEDFFSRRVLEESSSYPRTLRTVRPGLSEAPLPPLQKKRRRGLFHFRRPR 1062
Query: 1109 STRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPAGRSRPRY 1168
S +G R PG+ T G LL PP P +E SPDP
Sbjct: 1063 SFKGDR-----GPGS------PTTGLLLPPPPPPPPTQE------SPPSPDPPSLG---- 1101
Query: 1169 TRDSKAYSMILLPAEEEATL-----GARPDKRRPL-----ERGETELAPSFEQRVQVMLQ 1218
S +S P EE + L G P RR + E GE AP Q+ +V
Sbjct: 1102 NNSSPCWS----PEEESSLLPGFGGGRGPSFRRKMGTEGSEPGEGGPAPGTAQQPRVH-- 1155
Query: 1219 RIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPG 1278
GV+ G E + S DG+ + G D + ST+A K R+ + S +P
Sbjct: 1156 --GVA--LPGLERAKGWSFDGKREGPGPD---QEGSTQAWQ---KRRSSDDAGPGSWKPP 1205
Query: 1279 PGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLG----- 1333
P P +T + AE W + P QSPSP + G
Sbjct: 1206 P----PPQSTKPSFSAMRRAEAT---WHIAEESAPNHSCQSPSPASQDGEEEKEGTLFPE 1258
Query: 1334 --LP------EDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAE---------RPL 1376
LP +DP L P P+P++ R E ++ AE +P
Sbjct: 1259 RTLPARNAKLQDPALAP------WPPKPVAVPRGRQPPQEPGVREEAEAGDAAPGVNKPR 1312
Query: 1377 RLQRSPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTEPSS-------PERSPPSPATDQR 1429
S + P+++ PP P G T PL P+ T + R PP P
Sbjct: 1313 LRLSSQQDQEEPEVQGPPDP----GRRTAPLKPKRTRRAQSCDKLEPDRRRPPDPTGTSE 1368
Query: 1430 GG 1431
G
Sbjct: 1369 PG 1370
Score = 37.4 bits (85), Expect = 0.10
Identities = 51/192 (26%), Positives = 80/192 (41%), Gaps = 27/192 (14%)
Query: 1259 PISIKSRTHSVSADPSCRPG-PGSQGPESATWKTLGQQLNAELRSRGWG-QQDGPGPPSP 1316
P ++S+ ++ P G GSQ S +W+ L +EL + G+ + G P P
Sbjct: 927 PQDMESQLGNLGIPPGWFSGLGGSQPTASGSWEGL-----SELPTHGYKLRHQTQGRPRP 981
Query: 1317 GQSPSPCRTSPSPDSLGLPEDPCLGPRNEDG-------QLRPRPLSAGRRAVSVHEDQLQ 1369
++ P PS + G ++ + R ++G ++ S R +V +
Sbjct: 982 PRTTPPGPGRPSMPAPGTRQENGMATRLDEGLEDFFSRRVLEESSSYPRTLRTVRPGLSE 1041
Query: 1370 APAERPLRLQRSPVLK--RRPKL----EAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPS 1423
AP PL+ +R L RRP+ P SP+ G L P PP PT+ SPPS
Sbjct: 1042 APLP-PLQKKRRRGLFHFRRPRSFKGDRGPGSPTTGLLLPPPP-PPPPTQ-----ESPPS 1094
Query: 1424 PATDQRGGGPNP 1435
P G +P
Sbjct: 1095 PDPPSLGNNSSP 1106
>gi|63054866 leucine rich repeat containing 16A [Homo sapiens]
Length = 1326
Score = 615 bits (1587), Expect = e-176
Identities = 433/1360 (31%), Positives = 697/1360 (51%), Gaps = 121/1360 (8%)
Query: 39 VQNHVLALLRWRAYLLHTTCLPLRVDCTFSYLEVQAMALQETPPQVTFELESLRELVLEF 98
V+N VL L RA+L+ T +P +++ TFSYLE+ + ++ Q+ E E + ++
Sbjct: 41 VENKVLVLTSCRAFLV-TARIPTKLELTFSYLEIHGVVCSKSA-QMIVETEKC-SISMKM 97
Query: 99 PGVAALEQLAQHVAAAIKKVFPRSTLGKLFRRPT--PASMLARLERSSPSESTDPCSPCG 156
+ ++ H+ ++K+FP + ++ ++ + P+ LA L+ S++ PCG
Sbjct: 98 ASPEDVSEVLAHIGTCLRKIFPGLSPVRIMKKVSMEPSERLASLQALWDSQTVAEQGPCG 157
Query: 157 GFLETYEALCDYNGFPFREEIQWDVDTIYHRQGCRHFSLGDFSHLGSRDLALSVAALSYN 216
GF + Y +CD+ GF +REE+QWDVDTIY Q R +L DFSHL RDL +AAL YN
Sbjct: 158 GFSQMYACVCDWLGFSYREEVQWDVDTIYLTQDTRELNLQDFSHLDHRDLIPIIAALEYN 217
Query: 217 LWFRCLSCVDMKLSLEVSEQILHMMSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSG 276
WF LS D+KLS +V EQIL ++S+S+ LEELVLE LR DF ++LA ALA + +SG
Sbjct: 218 QWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSG 277
Query: 277 LRELSLAGNLLDDRGMTALSRHLERCPGALRRLSLAQTGLTPRGMRALGRALATNAAFDS 336
L ++LAGN L+DRG+++LS + P L+ L+L++T L+P+G+ +L ++L+ N S
Sbjct: 278 LHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTAS 337
Query: 337 TLTHLDLSGNPGALGASEDSGGLYSFLSRPNVLSFLNLAGTDTALDTVRGCSVGGWMTGR 396
TL HLDLSGN + +D +Y+FL++PN + L+L+ T+ +LD V G
Sbjct: 338 TLVHLDLSGN---VLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCG---------- 384
Query: 397 ADWRAGRGGLGPPAGVANSLPPQLFAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQL 456
A+ RGC L L+ SR VFS K + P + +
Sbjct: 385 --------------------------ALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQ 418
Query: 457 FLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLV 516
F S + L H+ L+G KL P+ L+ALL GLA N +L+ + LDLS CELRS GAQV++ +
Sbjct: 419 FFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCI 478
Query: 517 CDAGAVSSLDLADNGFGSDMVTLVLAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQL 576
+ ++SLD++DNG SD+ TL++ + ++RS++H+ALG+NFN + L VL +VQ+
Sbjct: 479 AEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQM 538
Query: 577 MQDDDCPLQSLSVAESRLKLGASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRVN 636
+QD++ PLQSLS+A+S+LK ++++ AL +N +LT +DISGN MGD GAK+LAKAL++N
Sbjct: 539 IQDEESPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQIN 598
Query: 637 SRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLNDVAQAQRSRPELTARAVHQIQ 696
++LR+V+WD+N+ +A G D+A A+E+N++L+ MP+P+ D +QA ++ PE T A+ +I+
Sbjct: 599 TKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTNPEKTEDALQKIE 658
Query: 697 ACLLRNNRADPASSDHTTRLQPLGLVSDPSEQEVNELCQSVQEHVELLGCGAGPQGEAAV 756
LLRN+ + RLQ G+V+ ++Q ++ +C VQ+H+ L G + +
Sbjct: 659 NYLLRNHETRKYLQEQAYRLQQ-GIVTSTTQQMIDRICVKVQDHLNSLRNCGGDAIQEDL 717
Query: 757 RQAEDAIQNANFSLSILPILYE------AGSSPSHHWQLGQKLEGLLRQVGEVCRQDIQD 810
+ AE +++A S ++LP LY AG+S + + LE + +V V + ++
Sbjct: 718 KSAERLMRDAKNSKTLLPNLYHVGGASWAGASGLLSSPIQETLESMAGEVTRVVDEQLKA 777
Query: 811 FTQATLDTARSLCPQMLQGSSWREQLEGVLAGSRGLP-----ELLPEQLLQDAFTRLRDM 865
++ +D A +LCP +++ + R+ L +P +L EQ D ++ ++
Sbjct: 778 LLESMVDAAENLCPNVMKKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEV 837
Query: 866 RLSITGTLAESIVAQALAGLSAARDQLVESLAQQATVTMPPALPAPDGGEPSLLEPGELE 925
+L++ L++ IV + L LS +L + +++ LP + E L E ++
Sbjct: 838 KLTVASFLSDRIVDEILDALSHCHHKLADHFSRRG-----KTLPQQESLEIELAEEKPVK 892
Query: 926 -GLFFPEEKEEEKEKDD-----SPPQKWPELSHGLHLVPFIHSAAEEAEPEPELAAPGED 979
+ EE E + +D P+ + H L P + E + + L
Sbjct: 893 RSIITVEELTEIERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIH 952
Query: 980 AEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGP 1039
E PS R + LP + G+ L H T+ RP+R +P
Sbjct: 953 IEDPPFPSLRQEKRSSG---FISELPSEE----GKKLEHFTKL--RPKRNKKQQPTQAAV 1003
Query: 1040 QVPPALPQEG--NGLSARVDEGVEEFFSKRLIQQD-RLWA---PEEDPATEGGATPVPRT 1093
+ Q+G NGL RVDEGV+EFF+K++ + D + W+ E EGG R
Sbjct: 1004 CAANIVSQDGEQNGLMGRVDEGVDEFFTKKVTKMDSKKWSTRGSESHELNEGGDEKKKRD 1063
Query: 1094 LRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGAEG 1153
RK G L K + P T L T ++P+ G + PP R
Sbjct: 1064 SRKSSGFLNLIKSRSKSERPPTILMTEEPSSPK------GAVRSPPVDCPR--------K 1109
Query: 1154 DTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRV 1213
DT + + G +S+ I P E + G K +ER +++ +P +R
Sbjct: 1110 DTKAAEHNG--------NSERIEEIKTPDSFEESQGEEIGK---VERSDSKSSPQAGRRY 1158
Query: 1214 QVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADP 1273
V + G+ AE K KQ + G ++ P SR+ S S+ P
Sbjct: 1159 GVQVMGSGLL-----AEMKAKQENRFGL------GTPEKNTKAEPKAEAGSRSRSSSSTP 1207
Query: 1274 SCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLG 1333
+ P P Q P+ + SR D P P P + PS
Sbjct: 1208 T-SPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVPSDKERD 1266
Query: 1334 LPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAE 1373
P PR ++ R S G++A E + ++ ++
Sbjct: 1267 GQSSPQPSPRTFSQEVSRR--SWGQQAQEYQEQKQRSSSK 1304
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 108 bits (271), Expect = 3e-23
Identities = 139/477 (29%), Positives = 208/477 (43%), Gaps = 40/477 (8%)
Query: 211 AALSYNLWFRCLSCVDMKLSLEVSEQILH-MMSQSSHLEELVLETCSLRGDFVRRLAQAL 269
AAL+Y L + LSL +S+ +L ++ Q + +L L+T + + L L
Sbjct: 602 AALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVL 661
Query: 270 AGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGALRRLSLAQTGLTPRGMRALGRALA 329
+G ++++SLA N + ++G AL+R L +L L L + P+G +AL AL
Sbjct: 662 SGKDCR-IQKISLAENQISNKGAKALARSL-LVNRSLTSLDLRGNSIGPQGAKALADALK 719
Query: 330 TNAAFDSTLTHLDLSGNPGALGASEDSGGLYSFLSRPNVLSFLNLAGTDTA-LDTVRGCS 388
N TLT L L GN + + + L+ LS L+L + R
Sbjct: 720 INR----TLTSLSLQGNTVR---DDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMAD 772
Query: 389 VGGWMTGRADWRAGRGGLGPPAGVANSLPPQLFAAVSRGCCTSLTHLDASRNVFSRTKSR 448
+ +G G A +L L V++G L LD N S
Sbjct: 773 ALKQNRSLKELMFSSNSIGD--GGAKALAEAL--KVNQG----LESLDLQSNSISD---- 820
Query: 449 AAPAALQLFLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAG 508
A AAL L +TL L L + P+ +A+ L N+ L++L DL+A L G
Sbjct: 821 AGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNL--DLTANLLHDQG 878
Query: 509 AQVIQDLVCDAGAVSSLDLADNGFGSDMV-TLVLAIGRSRSLRHVALGRNFNVRCKETLD 567
A+ I V + ++SL L N + L A+ +RSL + L N D
Sbjct: 879 ARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQEN------AIGD 932
Query: 568 DVLHRIVQLMQDDDCP----LQSLSVAESRLKLGASVLLRALATNPNLTALDISGNAMGD 623
D + + ++ + LQ S+ S GA VL ALA N L LD+ GNA+G
Sbjct: 933 DGACAVARALKVNTALTALYLQVASIGAS----GAQVLGEALAVNRTLEILDLRGNAIGV 988
Query: 624 AGAKLLAKALRVNSRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLNDVAQA 680
AGAK LA AL+VNS LR + N G + +A AL NH L+ + L N + +
Sbjct: 989 AGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDS 1045
Score = 68.9 bits (167), Expect = 3e-11
Identities = 105/404 (25%), Positives = 166/404 (41%), Gaps = 31/404 (7%)
Query: 282 LAGNLLDDRGMTALSRHLERCPGALRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHL 341
L G L D + A + ++ C L+ LA++ M + A T A + L +L
Sbjct: 550 LQGCLRPDAAVCARAINVLHCLHELQHTELARS--VEEAMESGALARLTGPAHRAALAYL 607
Query: 342 ----DLSGNPGALGASEDSGGLYSFLSRPNVLSFLNLAGTDTALDTVRGCSVGGWMTGRA 397
D L S G L S L + L L T+ D V +G ++G+
Sbjct: 608 LQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRL-DTNQFQDPVMEL-LGSVLSGK- 664
Query: 398 DWRAGRGGLGPPAGVANSLPPQLFAAVSRGCCT--SLTHLDASRNVFSRTKSRAAPAALQ 455
D R + L N + + A++R SLT LD N ++A AL+
Sbjct: 665 DCRIQKISLAE-----NQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALK 719
Query: 456 LFLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDL 515
+ RTL L L G + D R++ + LA N L LHL ++ + GAQ + D
Sbjct: 720 I----NRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNS--IGPMGAQRMADA 773
Query: 516 VCDAGAVSSLDLADNGFG-SDMVTLVLAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIV 574
+ ++ L + N G L A+ ++ L + L N ++ D +
Sbjct: 774 LKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSN-------SISDAGVAAL 826
Query: 575 QLMQDDDCPLQSLSVAESRLK-LGASVLLRALATNPNLTALDISGNAMGDAGAKLLAKAL 633
+ L SLS+ E+ + GA + AL N L LD++ N + D GA+ +A A+
Sbjct: 827 MGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAV 886
Query: 634 RVNSRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLNDV 677
R N L S+ N A + QAL+ N SL ++ L N +
Sbjct: 887 RENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAI 930
Score = 36.6 bits (83), Expect = 0.18
Identities = 80/324 (24%), Positives = 120/324 (37%), Gaps = 54/324 (16%)
Query: 193 FSLGDFSHLGSRDLALSVAALSYNLWFRCLSCVDMKLSLEVSEQILHMMSQSSHLEELVL 252
FS G++ LA AL N L +S ++ + + L L L
Sbjct: 785 FSSNSIGDGGAKALA---EALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSL 841
Query: 253 ETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGALRRLSLA 312
S+ + + +A AL +S+ L+ L L NLL D+G A++ + R L L L
Sbjct: 842 RENSISPEGAQAIAHALCANST--LKNLDLTANLLHDQGARAIAVAV-RENRTLTSLHLQ 898
Query: 313 QTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNPGALGASEDSGGLYSFLSRPNVLSFL 372
+ +ALG+AL N +LT LDL
Sbjct: 899 WNFIQAGAAQALGQALQLN----RSLTSLDLQE--------------------------- 927
Query: 373 NLAGTDTALDTVRGCSVGGWMTGRADWRAGRGGLGPPAGVANSLPPQLFAAVSRGCCTSL 432
N G D A R V +T A G G A L L AV+R +L
Sbjct: 928 NAIGDDGACAVARALKVNTALTALYLQVASIGASG-----AQVLGEAL--AVNR----TL 976
Query: 433 THLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHL 492
LD N ++A AL++ S LR L L L D + L+ N L
Sbjct: 977 EILDLRGNAIGVAGAKALANALKVNSS----LRRLNLQENSLGMDGAICIATALSGNHRL 1032
Query: 493 RDLHLDLSACELRSAGAQVIQDLV 516
+ H++L + +GA++I + +
Sbjct: 1033 Q--HINLQGNHIGDSGARMISEAI 1054
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 78.2 bits (191), Expect = 5e-14
Identities = 146/575 (25%), Positives = 191/575 (33%), Gaps = 110/575 (19%)
Query: 899 QATVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEE-----EKEKDDSPPQKWPE--LS 951
+A V + P L AP E LL P E L P E+ E + PP++ P L
Sbjct: 421 KAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLP 480
Query: 952 HGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQA-------GPSARGSPSPA-----APGP 999
LHL + + PE +P ++ P + P PSPA +P P
Sbjct: 481 EALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPP 540
Query: 1000 PAGPL--PRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPP------ALPQEGNG 1051
A PL P + PL+ P PT P P PP P PP + P E +
Sbjct: 541 EASPLSPPFEESPLSPPPEELPTS--PPPEASRLSPPPEESPMSPPPEESPMSPPPEASR 598
Query: 1052 LSARVDEGV-----EEFFSKRLIQQDRLWAPEED-----PATEGGATPVPRTLRKKLGTL 1101
L +E EE + RL P ED P E +P P R +
Sbjct: 599 LFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPV 658
Query: 1102 FAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPA 1161
+ P P L P +P + L PP E +SP P
Sbjct: 659 VSRLSPPPEESP---LSPPPEESPTSPPPEASRLSPPP------------EDSPTSPPPE 703
Query: 1162 GRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIG 1221
DS ++ LP EE L PL E +L P
Sbjct: 704 DSPASPPPEDS----LMSLPLEESPLL--------PLPE-EPQLCPR------------- 737
Query: 1222 VSRGSGGAEGKRKQSKDGEIKKAGSDGDI-MDSSTEAPPISIKSRTHSVSADPSCRP--G 1278
+EG + E + + + E P +S + + A P P
Sbjct: 738 -------SEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPE-EPHLS 789
Query: 1279 PGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPEDP 1338
P ++GP + Q L + P P P SP P + SP S E+P
Sbjct: 790 PQAEGPHLSP-----QPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQS----EEP 840
Query: 1339 CLGPRNEDGQLRPR----PLSAGRRAVSVHEDQLQAPAERPL-----RLQRSPVLKRRPK 1389
CL PR E+ L P PLS Q AP E PL SP+L P
Sbjct: 841 CLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGE-PA 899
Query: 1390 LEAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPSP 1424
L P P L PL P SP+ PP P
Sbjct: 900 LSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDP 934
Score = 52.4 bits (124), Expect = 3e-06
Identities = 122/486 (25%), Positives = 160/486 (32%), Gaps = 104/486 (21%)
Query: 970 EPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQ 1029
EP+L AP + P P SP P P P L+ P P A P P
Sbjct: 427 EPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASR-LSPPPEELP--ASPLPEAL 483
Query: 1030 HHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDPATEGGATP 1089
H RP P PP P+E + LS + FS +++ L PEE P + TP
Sbjct: 484 HLSRPLEESPLSPP--PEE-SPLSPPPESSP---FSP--LEESPLSPPEESPPSPALETP 535
Query: 1090 V-PRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGA-APRTRKTTFGDLLRPPTRPSRGEE 1147
+ P L F + P S P +L TSP A R + PP
Sbjct: 536 LSPPPEASPLSPPFE-ESPLSP--PPEELPTSPPPEASRLSPPPEESPMSPPPE------ 586
Query: 1148 LGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRR---PLERGETE 1204
E S P A R P + L P EE+ L P+ R P E ++
Sbjct: 587 ----ESPMSPPPEASRLFPPFEESP------LSPPPEESPLSPPPEASRLSPPPE--DSP 634
Query: 1205 LAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKS 1264
++P E+ S E+ + P+ + S
Sbjct: 635 MSPPPEES---------------------PMSPPPEVSRLS-------------PLPVVS 660
Query: 1265 RTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCR 1324
R + P P + P S E +D P P P SP+
Sbjct: 661 RLSPPPEESPLSPPP-EESPTSPP---------PEASRLSPPPEDSPTSPPPEDSPA--- 707
Query: 1325 TSPSPDS------------LGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPA 1372
SP P+ L LPE+P L PR+E L PRP + E L A
Sbjct: 708 -SPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRP-EEPHLSPRPEEPHLSPQA 765
Query: 1373 ERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTE-PSSPERSPP--SPATDQR 1429
E P SP + P P L L PQP E SP+ P SP ++
Sbjct: 766 EEP---HLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEP 822
Query: 1430 GGGPNP 1435
P P
Sbjct: 823 CLSPQP 828
Score = 50.1 bits (118), Expect = 2e-05
Identities = 141/588 (23%), Positives = 188/588 (31%), Gaps = 112/588 (19%)
Query: 892 LVESLAQQATVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELS 951
L E+L + P P P E S L P F P E+ ++SPP P L
Sbjct: 479 LPEALHLSRPLEESPLSPPP---EESPLSPPPESSPFSPLEESPLSPPEESPPS--PALE 533
Query: 952 HGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSA-RGSP----SPAAPGPPAGPLP- 1005
L P + E P L+ P E+ P A R SP SP +P P P+
Sbjct: 534 TPLSPPPEASPLSPPFEESP-LSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSP 592
Query: 1006 -----RMDLPLAGQPLRHP---TRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVD 1057
R+ P PL P + P P PP P PP P+E + +
Sbjct: 593 PPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPP--PEE-----SPMS 645
Query: 1058 EGVEEFFSKRLIQQDRLWAPEED-----PATEGGATPVPRTLRKKLGTLFAFKKPRSTRG 1112
E L RL P E+ P E +P P R L + T
Sbjct: 646 PPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASR-----LSPPPEDSPTSP 700
Query: 1113 PRTDLETSPGAAPRTRKTTFGD--LLRPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTR 1170
P D SP + LL P P G +P RP
Sbjct: 701 PPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPH 760
Query: 1171 DS-KAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGA 1229
S +A L P EE L A P+ E L+P A
Sbjct: 761 LSPQAEEPHLSPQPEEPCLCAVPE--------EPHLSPQ--------------------A 792
Query: 1230 EGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADP-SCRPGPGSQGPESAT 1288
EG + E+ + TE P +S +S P P S+ P +
Sbjct: 793 EGPHLSPQPEELH--------LSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEP-CLS 843
Query: 1289 WKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPS---------PCRTSPSP----DSLGLP 1335
+ L+ EL + P PGQ P+ P S SP +L P
Sbjct: 844 PRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEP 903
Query: 1336 EDPCLGPRNEDGQLRPRPLSAGRRAVS---VHEDQLQAPAERPLRLQRSPVLKRRPKLEA 1392
+P L P E+ L P +G ++S + D L P + P L +LE
Sbjct: 904 GEPPLSPLPEELPLSP----SGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEY 959
Query: 1393 P--------PSPSLGSGLGTEPLPPQP------TEPSSPERSPPSPAT 1426
P P L + + P+ P P EP P PPSP +
Sbjct: 960 PFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGS 1007
Score = 42.0 bits (97), Expect = 0.004
Identities = 63/223 (28%), Positives = 83/223 (37%), Gaps = 48/223 (21%)
Query: 905 PPALPA--PDGGEPSLLEPGELEGLFFPEEKEEEKEKDDS-PPQKWPELSHGLHLVPFIH 961
PP P+ P GEP+L EPGE PEE + S PQ P L P I
Sbjct: 885 PPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIIT 944
Query: 962 SAAEEA-----------------EPEPELAAP-----------GEDAEPQAGPSARGSPS 993
+AA A +PE LAAP +P+ P PS
Sbjct: 945 AAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPS 1004
Query: 994 PAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQ--VPPALPQEGNG 1051
P +P PA P+ L P + P QH P P PPALP
Sbjct: 1005 PGSPVGPASPI-----------LMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPS 1053
Query: 1052 LSARVDE--GVEEFFSKRLIQQDRLWAPEEDPATEGGAT-PVP 1091
+ + + GV + ++ +++ P E PA E AT P+P
Sbjct: 1054 PLSPIGKVVGVSDEAELHEMETEKVSEP-ECPALEPSATSPLP 1095
Score = 41.6 bits (96), Expect = 0.006
Identities = 113/464 (24%), Positives = 146/464 (31%), Gaps = 106/464 (22%)
Query: 974 AAPGEDAEPQAGPSARGSPSPAAPGPPAGP--LPRMDLPLAGQPLRHPTRARPRPRRQHH 1031
A P E P A P+ PSP G PA P L P AGQP
Sbjct: 2182 AYPLEPRFPTAPPTYPPYPSPT--GAPAQPPMLGASSRPGAGQP-------------GEF 2226
Query: 1032 HRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDPATEGGATPVP 1091
H PPG P+ P+ P + F R D L P E P GG P
Sbjct: 2227 HTTPPGTPRHQPSTP--------------DPFLKPRCPSLDNLAVP-ESPGVGGGKASEP 2271
Query: 1092 RTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGA 1151
G S + E ++P G + PS G LGG
Sbjct: 2272 LLSPPPFG--------ESRKALEVKKEELGASSPSYGPPNLGFV----DSPSSGTHLGGL 2319
Query: 1152 EGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQ 1211
E T P P R S+ + LG RP + P + LAPS
Sbjct: 2320 ELKT----PDVFKAPLTPRASQV-------EPQSPGLGLRPQEPPPAQ----ALAPSPPS 2364
Query: 1212 RVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKS-RTHSVS 1270
+ + G + + PP S + S+
Sbjct: 2365 HPDIF--------------------RPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLP 2404
Query: 1271 ADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPG-QSPSPCRTSPSP 1329
+DP R Q S+ + L+AE P P +P QSP P PS
Sbjct: 2405 SDPFSRVPASPQSQSSSQSPLTPRPLSAEAFC--------PSPVTPRFQSPDPYSRPPSR 2456
Query: 1330 DSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPK 1389
P P P RP+P +A S+ L A P L P + K
Sbjct: 2457 PQSRDPFAPLHKPP------RPQPPEVAFKAGSLAHTSLGA-GGFPAALPAGPAGELHAK 2509
Query: 1390 LEA--PP----SPSLGSGLGTEPLPPQPTEPSS---PERSPPSP 1424
+ + PP SP G+ +GT P P + T P + P PP P
Sbjct: 2510 VPSGQPPNFVRSPGTGAFVGT-PSPMRFTFPQAVGEPSLKPPVP 2552
Score = 41.2 bits (95), Expect = 0.007
Identities = 142/569 (24%), Positives = 192/569 (33%), Gaps = 112/569 (19%)
Query: 885 LSAARDQLVESLAQQATVTMPPALPAPDGGEPS---LLEPGELEGLFFP-EEKEEEKEKD 940
LS ++L S +A+ PP +P P + P E LF P EE +
Sbjct: 554 LSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPE 613
Query: 941 DSPPQKWPELSHGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPS--ARGSPSPA--- 995
+SP PE S L P PE +P + P + P +R SP P
Sbjct: 614 ESPLSPPPEASR---LSP---------PPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSR 661
Query: 996 -APGPPAGPL--PRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGL 1052
+P P PL P + P + P +R P P PP P PP P+
Sbjct: 662 LSPPPEESPLSPPPEESPTSPPP--EASRLSPPPEDSPTSPPPEDSPASPP--PE----- 712
Query: 1053 SARVDEGVEEFFSKRLIQQDRLWAPEED---PATEGGATPVPRTLRKKLGTLFAFKKPRS 1109
+ S L + L PEE P +EG PR L PR
Sbjct: 713 --------DSLMSLPLEESPLLPLPEEPQLCPRSEGPHLS-PRPEEPHL-------SPRP 756
Query: 1110 TRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYT 1169
+ P +P+ + L P P + AEG SP P T
Sbjct: 757 EEPHLSPQAEEPHLSPQPEEPC---LCAVPEEPHLSPQ---AEGPHLSPQPEELHLSPQT 810
Query: 1170 RDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGA 1229
+ L P EE L +P+ E+ L+P E+ + R S S
Sbjct: 811 EEPH-----LSPVPEEPCLSPQPE--------ESHLSPQSEE--PCLSPRPEESHLSPEL 855
Query: 1230 EGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPG--PGSQGPESA 1287
E + + + + PP S + + PG P S PE
Sbjct: 856 EKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEEL 915
Query: 1288 TWKTLGQ-QLNAELRSRGWGQQDGPGPPSPGQSP-SPCRTSPSPDSLGLPEDPCLGPRNE 1345
G+ L+ +L PP P P SP T+ +P +L P P
Sbjct: 916 PLSPSGEPSLSPQLM-----------PPDPLPPPLSPIITAAAPPALS-PLGELEYPFGA 963
Query: 1346 DGQLRPR-PLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLG- 1403
G P PL+A + E + P E PV P + PPSP GS +G
Sbjct: 964 KGDSDPESPLAA-----PILETPISPPPEANC-TDPEPV----PPMILPPSP--GSPVGP 1011
Query: 1404 -----TEPLPPQ--PTEPSS--PERSPPS 1423
EPLPPQ P S P+ SPPS
Sbjct: 1012 ASPILMEPLPPQCSPLLQHSLVPQNSPPS 1040
Score = 40.4 bits (93), Expect = 0.012
Identities = 63/242 (26%), Positives = 97/242 (40%), Gaps = 46/242 (19%)
Query: 842 GSRGLPELLPEQLLQDAFTRLRDMRLSITGTLAESIVAQALAGLSAARDQLVESLAQQAT 901
G+ GL +P +L + + + +S+ T++ + A+ L G+ A +L+ +
Sbjct: 4759 GALGLE--VPGKLPVTTWEKGKGSEVSVMLTVSAA-AAKNLNGVMVAVAELLSMKIPNSY 4815
Query: 902 VTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPP--QKWPELSHGLHLVPF 959
+ P PA G EP + GE EG E+ E K D P +++ + G L
Sbjct: 4816 EVLFPESPARAGTEP---KKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQ 4872
Query: 960 IH--SAAEEAEPEPE-------------------LAAPGEDAEPQAGPSARGSPSPAAPG 998
+ S ++ P PE A P E+ P P A PSPA+P
Sbjct: 4873 LDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLA---PSPASP- 4928
Query: 999 PPAGPLPRMDL-PLAGQPL-------RHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGN 1050
P PL + PLA P+ P ARP+PR RPP G P ++
Sbjct: 4929 -PTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRA----RPPEEGEDSRPPRLKKWK 4983
Query: 1051 GL 1052
G+
Sbjct: 4984 GV 4985
Score = 40.0 bits (92), Expect = 0.016
Identities = 58/205 (28%), Positives = 76/205 (37%), Gaps = 36/205 (17%)
Query: 1257 APPISIKSRTH----SVSADPSCRPGPGS-QGPESA--TWKTLGQQLNAELRSRGWGQQD 1309
AP I I S T S SAD +P GS GP+S + L Q+ A++ S+
Sbjct: 2121 APTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVPSQDPFGLA 2180
Query: 1310 GPGPPSPGQSPSPCRTSPSPDSLGLP-EDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQL 1368
P P +P P P G P + P LG + G +P H+
Sbjct: 2181 PAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPST 2240
Query: 1369 QAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPL--PP-------------QPTE 1413
P +P R P L L P SP +G G +EPL PP +
Sbjct: 2241 PDPFLKP----RCPSLDN---LAVPESPGVGGGKASEPLLSPPPFGESRKALEVKKEELG 2293
Query: 1414 PSSPERSPP------SPATDQRGGG 1432
SSP PP SP++ GG
Sbjct: 2294 ASSPSYGPPNLGFVDSPSSGTHLGG 2318
Score = 35.4 bits (80), Expect = 0.40
Identities = 117/509 (22%), Positives = 170/509 (33%), Gaps = 109/509 (21%)
Query: 966 EAEPEPELAAPGEDAEPQAG-PSARGSPSPAAPGPPAGPLPRMDLPLA-------GQPLR 1017
+A EP L P PQ G P G S PGP G + +A G PL
Sbjct: 2540 QAVGEPSLKPP----VPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLG 2595
Query: 1018 HPTRARPRPRRQHHHRPPPGGPQVPP--ALPQEGNGLSARVDEGVEEFFSKRLIQQDRLW 1075
+ + RPP P P +LP +G S R G+ KR
Sbjct: 2596 PSSGSTGESYGLSPLRPPSVLPPPAPDGSLPYLSHGASQR--SGITSPVEKR-------- 2645
Query: 1076 APEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDL 1135
EDP T G++ L GT + P + +T+LE R R+
Sbjct: 2646 ---EDPGTGMGSSLATAELP---GT----QDPGMSGLSQTELEKQR-QRQRLRELLIRQQ 2694
Query: 1136 LRPPTRPSRGEELGGAEGDTSSPDPAGR--SRPRYTRDSKAYSMILLPAEEEATLGARPD 1193
++ T E A G P G S P + + S+ + ++ + +G P
Sbjct: 2695 IQRNTLRQEKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPS 2754
Query: 1194 K------------------RRPLERGETELAPSFEQRV---QVMLQRIGVSRGSGGAEGK 1232
K R P + + + Q V Q QR + +
Sbjct: 2755 KLSGPILGPGSFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQ 2814
Query: 1233 RKQSKDGEIKKAGSDGDIMDS---STEAPPISIKSRTHSVSADPSCRPGPGSQGPESATW 1289
++ + + A S M + ST P + ++ ++ + PGPG P A
Sbjct: 2815 QQLWQQQQATAATSMRFAMSARFPSTPGPELGRQALGSPLAGISTRLPGPGEPVPGPA-- 2872
Query: 1290 KTLGQQLNAELRSRGWGQQDGPGP---PSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNED 1346
G ELR Q G GP P PGQ P P+ P P +ED
Sbjct: 2873 ---GPAQFIELRHN---VQKGLGPGGTPFPGQGP--------------PQRPRFYPVSED 2912
Query: 1347 GQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEP 1406
R G R ++V P ++P APP+P L + L P
Sbjct: 2913 PH---RLAPEGLRGLAVSG----LPPQKP---------------SAPPAPELNNSLHPTP 2950
Query: 1407 LPPQPTEPSSPERSPPSPATDQRGGGPNP 1435
PT P+ E P++ + G PNP
Sbjct: 2951 HTKGPTLPTGLELVNRPPSSTEL-GRPNP 2978
Score = 33.5 bits (75), Expect = 1.5
Identities = 68/292 (23%), Positives = 103/292 (35%), Gaps = 70/292 (23%)
Query: 1180 LPAEE--EATLGARPDKRRPLERGET-----ELAPSFEQRVQVMLQRIGVSRGSGGAEGK 1232
LPAE E +L +K++ RG ++ P++ Q + + +SR + A G
Sbjct: 1735 LPAEGAVEQSLAEGDEKKKQQRRGRKKSKLEDMFPAYLQEAFFGKELLDLSRKALFAVGV 1794
Query: 1233 RKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWKTL 1292
+ S KA DG S + P S K G GP+ A ++
Sbjct: 1795 GRPSFGLGTPKAKGDGG---SERKELPTSQK----------------GDDGPDIADEESR 1835
Query: 1293 GQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPR 1352
G + G+ D PGP G SP P+ G P + L +
Sbjct: 1836 GLE----------GKADTPGPEDGGVKASP--VPSDPEKPGTPGEGMLSSDLDRISTEEL 1883
Query: 1353 PLSAGRRAVSVHEDQLQAPAERPL-----RLQRSPVLKRRPKLEA-------PPSPSLGS 1400
P + + +D L + E+ L L+ S +RP L+ P S + S
Sbjct: 1884 PKMESKDLQQLFKDVLGSEREQHLGCGTPGLEGSRTPLQRPFLQGGLPLGNLPSSSPMDS 1943
Query: 1401 --GLGTEP----------LPPQPTEPSSP--------ERSPPSPATDQRGGG 1432
GL P P+P EP SP +P +P T+ G G
Sbjct: 1944 YPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDG 1995
Score = 32.7 bits (73), Expect = 2.6
Identities = 33/128 (25%), Positives = 50/128 (39%), Gaps = 21/128 (16%)
Query: 1313 PPSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLR------PRPLSAGRRAVSV-HE 1365
PP PG SP + +G P P + DG L+ P P S G + + +
Sbjct: 2107 PPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQ 2166
Query: 1366 DQLQAPAERPLRLQRSPVLKRRPKL-EAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPSP 1424
Q P++ P L +P P+ APP+ PP P+ +P + P
Sbjct: 2167 VPAQVPSQDPFGL--APAYPLEPRFPTAPPT-----------YPPYPSPTGAPAQPPMLG 2213
Query: 1425 ATDQRGGG 1432
A+ + G G
Sbjct: 2214 ASSRPGAG 2221
Score = 32.3 bits (72), Expect = 3.4
Identities = 43/148 (29%), Positives = 50/148 (33%), Gaps = 16/148 (10%)
Query: 1294 QQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPED------PCLGPRNEDG 1347
QQL A L R Q P Q P +TSP LG P GP E G
Sbjct: 4220 QQLQALLMQRQLQQSQAVRQTPPYQEPGT-QTSPLQGLLGCQPQLGGFPGPQTGPLQELG 4278
Query: 1348 QLRPRPLSAGRRAV---SVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGT 1404
PRP R ++ + P P SP +RP PS L +
Sbjct: 4279 A-GPRPQGPPRLPAPPGALSTGPVLGPVH-PTPPPSSPQEPKRPSQLPSPSSQLPTEAQL 4336
Query: 1405 EPLPPQPTEPSSPERSPP----SPATDQ 1428
P P +P P PP SPA Q
Sbjct: 4337 PPTHPGTPKPQGPTLEPPPGRVSPAAAQ 4364
Score = 31.6 bits (70), Expect = 5.7
Identities = 48/193 (24%), Positives = 66/193 (34%), Gaps = 40/193 (20%)
Query: 1219 RIGVSRGSGGAEGKRKQSKDGEIKKAGSDGD-IMDSSTEAPPISIKSRTHSVSADPSCRP 1277
R G G AEG + K E K + D + P ++KS+ +S P
Sbjct: 4825 RAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESP 4884
Query: 1278 GPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPED 1337
P S T+ N ++R Q P P P PSP SP+ P +
Sbjct: 4885 APEPPTQHSYTYNVS----NLDVR-----QLSAPPPEEPSPPPSPLAPSPASP----PTE 4931
Query: 1338 PCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPS 1397
P + +L PL+ + P PL L SP RPK A P
Sbjct: 4932 PLV-------ELPTEPLA-------------EPPVPSPLPLASSPE-SARPKPRARPPEE 4970
Query: 1398 LGSGLGTEPLPPQ 1410
G + PP+
Sbjct: 4971 -----GEDSRPPR 4978
Score = 31.2 bits (69), Expect = 7.5
Identities = 52/198 (26%), Positives = 65/198 (32%), Gaps = 47/198 (23%)
Query: 833 REQLEGVLAGSRGLPELLPEQLLQ-DAFTRLRDMRLS----ITGTLAE-SIVAQALAGLS 886
R QL+GVLA + L L P+Q Q A R ++ S T E L GL
Sbjct: 4198 RAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLL 4257
Query: 887 AARDQL----------VESLAQQATVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEEE 936
+ QL ++ L PP LPAP P L G + G P
Sbjct: 4258 GCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAP----PGALSTGPVLGPVHPTPPPSS 4313
Query: 937 KEKDDSPPQKWPELSHGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAA 996
++ P Q P P P E Q P+ G+P P
Sbjct: 4314 PQEPKRPSQL----------------------PSPSSQLP---TEAQLPPTHPGTPKP-- 4346
Query: 997 PGPPAGPLPRMDLPLAGQ 1014
GP P P P A Q
Sbjct: 4347 QGPTLEPPPGRVSPAAAQ 4364
Score = 30.8 bits (68), Expect = 9.8
Identities = 38/127 (29%), Positives = 51/127 (40%), Gaps = 33/127 (25%)
Query: 1313 PPSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPA 1372
PP PG +P+ PD+L + C G +P+ H +Q
Sbjct: 374 PPEPGDTPTD-----EPDALYVA---CQG--------QPK---------GGHVTSMQPKE 408
Query: 1373 ERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTE-PLPPQPTE-PSSP--ERSPPSPATDQ 1428
PL+ + P+ K +LE P L + L E PL P P E P SP E SP SP +
Sbjct: 409 PGPLQCEAKPLGKAGVQLE----PQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEA 464
Query: 1429 RGGGPNP 1435
P P
Sbjct: 465 SRLSPPP 471
>gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]
Length = 1120
Score = 63.9 bits (154), Expect = 1e-09
Identities = 125/500 (25%), Positives = 172/500 (34%), Gaps = 69/500 (13%)
Query: 896 LAQQATVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKE---EEKEKDDSPPQKWPELSH 952
L Q + P A GG P EP L P ++ + S Q P+ S
Sbjct: 583 LTFQGSELSPELQAAMAGGGP---EPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSG 639
Query: 953 GLHLVPFIHSAAEEAEPEPELAA--PGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLP 1010
G P + E E P+L + PG+ P +GSPS APGPP G P
Sbjct: 640 GDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGA-PWAFSY 698
Query: 1011 LAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQ 1070
LAG P P PRP+R+ H PG + EG S G ++R +
Sbjct: 699 LAGPPATPPDP--PRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTL---GSYATLTRRPGR 753
Query: 1071 QDRLWAPEEDPATEGGATPVPRTL----RKKLGTLFAFKKPRSTRGPRTD---LETSPG- 1122
+ T TP ++ R+K K+ S GP + L+ SPG
Sbjct: 754 SALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGP 813
Query: 1123 --AAPRTRKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILL 1180
A R+ T + P P G A DT +P P T S+ S L
Sbjct: 814 KEGATGPRRRTLSEPAGPSEPPGPPAPAGPAS-DTEEEEPG----PEGTPPSRGSSGEGL 868
Query: 1181 PAEEEA--TLGARPDKRRPLERGETELAPSFE------------------QRVQVMLQRI 1220
P EE T+ RP P R ET + P + + +Q L
Sbjct: 869 PFAEEGNLTIKQRPKPAGPPPR-ETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAF 927
Query: 1221 GVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAP--PISIKSRTHSVSADPSCRPG 1278
GV+ + G GE A S SS A P + P C PG
Sbjct: 928 GVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPC-PG 986
Query: 1279 PGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPEDP 1338
PG + ++ W G+ + P P+ T+P P S+ +
Sbjct: 987 PGLESSAASRWN---------------GETEPPAAPAALLKVPGAGTAPKPVSVACTQLA 1031
Query: 1339 CLGPRNEDGQLRPRPLSAGR 1358
GP+ +L PRP+ R
Sbjct: 1032 FSGPKLAP-RLGPRPVPPPR 1050
Score = 53.5 bits (127), Expect = 1e-06
Identities = 129/518 (24%), Positives = 163/518 (31%), Gaps = 138/518 (26%)
Query: 949 ELSHGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARG-----------SPSPAAP 997
EL GL + PEL A E E GP+ G SP A
Sbjct: 539 ELRRGLLQGEALSEGGRRLAKGPELMAI-EGLENGEGPATAGPRLLTFQGSELSPELQAA 597
Query: 998 GPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVD 1057
GP P + LP A P + AR R +P P P+ PQE N +
Sbjct: 598 MAGGGPEP-LPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERN-----LP 651
Query: 1058 EGVEEFFSKRLIQQDRLWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDL 1117
EG E P + ++ G P P + F P+ + P +
Sbjct: 652 EGTER--------------PPKLCSSLPGQGPPP----------YVFMYPQGS--PSSPA 685
Query: 1118 ETSPGAAPRTRKTTFGDLLRP--PTRPSR--------GEELGGAEGDTSSPDPAGRSRPR 1167
P AP G P P RP R G G AEG+ P G +
Sbjct: 686 PGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEG--PVGSTLGS 743
Query: 1168 YTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSG 1227
Y ATL RP R L R + P+ + G R
Sbjct: 744 Y-----------------ATLTRRPG-RSALVRTSPSVTPTPAR---------GTPRSQS 776
Query: 1228 GA-EGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPES 1286
A +RK K+ S + S E PP+ D S P G+ GP
Sbjct: 777 FALRARRKGPPPPPPKRLSS---VSGPSPEPPPL-----------DESPGPKEGATGPRR 822
Query: 1287 ATWKTLGQQLNAELRSRGWGQQDGPGPPSPG--------QSPSPCRTSPSPDSLGLPEDP 1338
T S G + PGPP+P + P P T PS S G
Sbjct: 823 RT------------LSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGL-- 868
Query: 1339 CLGPRNEDGQL----RPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKL-EAP 1393
P E+G L RP+P R V P L S +KRRPK E
Sbjct: 869 ---PFAEEGNLTIKQRPKPAGPPPRETPV-------PPGLDFNLTESDTVKRRPKCRERE 918
Query: 1394 PSPSLGSGLGTEPLPPQPTEP---SSPERSPPSPATDQ 1428
P + G P P P +P SPP+ + Q
Sbjct: 919 PLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQ 956
Score = 39.7 bits (91), Expect = 0.021
Identities = 52/191 (27%), Positives = 66/191 (34%), Gaps = 41/191 (21%)
Query: 1254 STEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGP 1313
+T P K R+HS+S RPGP E +G L + +
Sbjct: 704 ATPPDPPRPKRRSHSLS-----RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVR 758
Query: 1314 PSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAE 1373
SP +P+P R +P S L G P P +R SV P+
Sbjct: 759 TSPSVTPTPARGTPRSQSFALRA-------RRKGPPPPPP----KRLSSV-----SGPSP 802
Query: 1374 RPLRLQRSPVLK------RRPKLEAPPSPSLGSGLGTEPLPPQPTEPSS--------PER 1419
P L SP K RR L P PS P PP P P+S PE
Sbjct: 803 EPPPLDESPGPKEGATGPRRRTLSEPAGPS------EPPGPPAPAGPASDTEEEEPGPEG 856
Query: 1420 SPPSPATDQRG 1430
+PPS + G
Sbjct: 857 TPPSRGSSGEG 867
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 63.9 bits (154), Expect = 1e-09
Identities = 125/500 (25%), Positives = 172/500 (34%), Gaps = 69/500 (13%)
Query: 896 LAQQATVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKE---EEKEKDDSPPQKWPELSH 952
L Q + P A GG P EP L P ++ + S Q P+ S
Sbjct: 665 LTFQGSELSPELQAAMAGGGP---EPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSG 721
Query: 953 GLHLVPFIHSAAEEAEPEPELAA--PGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLP 1010
G P + E E P+L + PG+ P +GSPS APGPP G P
Sbjct: 722 GDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGA-PWAFSY 780
Query: 1011 LAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQ 1070
LAG P P PRP+R+ H PG + EG S G ++R +
Sbjct: 781 LAGPPATPPDP--PRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTL---GSYATLTRRPGR 835
Query: 1071 QDRLWAPEEDPATEGGATPVPRTL----RKKLGTLFAFKKPRSTRGPRTD---LETSPG- 1122
+ T TP ++ R+K K+ S GP + L+ SPG
Sbjct: 836 SALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGP 895
Query: 1123 --AAPRTRKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILL 1180
A R+ T + P P G A DT +P P T S+ S L
Sbjct: 896 KEGATGPRRRTLSEPAGPSEPPGPPAPAGPAS-DTEEEEPG----PEGTPPSRGSSGEGL 950
Query: 1181 PAEEEA--TLGARPDKRRPLERGETELAPSFE------------------QRVQVMLQRI 1220
P EE T+ RP P R ET + P + + +Q L
Sbjct: 951 PFAEEGNLTIKQRPKPAGPPPR-ETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAF 1009
Query: 1221 GVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAP--PISIKSRTHSVSADPSCRPG 1278
GV+ + G GE A S SS A P + P C PG
Sbjct: 1010 GVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPC-PG 1068
Query: 1279 PGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPEDP 1338
PG + ++ W G+ + P P+ T+P P S+ +
Sbjct: 1069 PGLESSAASRWN---------------GETEPPAAPAALLKVPGAGTAPKPVSVACTQLA 1113
Query: 1339 CLGPRNEDGQLRPRPLSAGR 1358
GP+ +L PRP+ R
Sbjct: 1114 FSGPKLAP-RLGPRPVPPPR 1132
Score = 53.5 bits (127), Expect = 1e-06
Identities = 129/518 (24%), Positives = 163/518 (31%), Gaps = 138/518 (26%)
Query: 949 ELSHGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARG-----------SPSPAAP 997
EL GL + PEL A E E GP+ G SP A
Sbjct: 621 ELRRGLLQGEALSEGGRRLAKGPELMAI-EGLENGEGPATAGPRLLTFQGSELSPELQAA 679
Query: 998 GPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVD 1057
GP P + LP A P + AR R +P P P+ PQE N +
Sbjct: 680 MAGGGPEP-LPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERN-----LP 733
Query: 1058 EGVEEFFSKRLIQQDRLWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDL 1117
EG E P + ++ G P P + F P+ + P +
Sbjct: 734 EGTER--------------PPKLCSSLPGQGPPP----------YVFMYPQGS--PSSPA 767
Query: 1118 ETSPGAAPRTRKTTFGDLLRP--PTRPSR--------GEELGGAEGDTSSPDPAGRSRPR 1167
P AP G P P RP R G G AEG+ P G +
Sbjct: 768 PGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEG--PVGSTLGS 825
Query: 1168 YTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSG 1227
Y ATL RP R L R + P+ + G R
Sbjct: 826 Y-----------------ATLTRRPG-RSALVRTSPSVTPTPAR---------GTPRSQS 858
Query: 1228 GA-EGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPES 1286
A +RK K+ S + S E PP+ D S P G+ GP
Sbjct: 859 FALRARRKGPPPPPPKRLSS---VSGPSPEPPPL-----------DESPGPKEGATGPRR 904
Query: 1287 ATWKTLGQQLNAELRSRGWGQQDGPGPPSPG--------QSPSPCRTSPSPDSLGLPEDP 1338
T S G + PGPP+P + P P T PS S G
Sbjct: 905 RT------------LSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGL-- 950
Query: 1339 CLGPRNEDGQL----RPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKL-EAP 1393
P E+G L RP+P R V P L S +KRRPK E
Sbjct: 951 ---PFAEEGNLTIKQRPKPAGPPPRETPV-------PPGLDFNLTESDTVKRRPKCRERE 1000
Query: 1394 PSPSLGSGLGTEPLPPQPTEP---SSPERSPPSPATDQ 1428
P + G P P P +P SPP+ + Q
Sbjct: 1001 PLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQ 1038
Score = 39.7 bits (91), Expect = 0.021
Identities = 52/191 (27%), Positives = 66/191 (34%), Gaps = 41/191 (21%)
Query: 1254 STEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGP 1313
+T P K R+HS+S RPGP E +G L + +
Sbjct: 786 ATPPDPPRPKRRSHSLS-----RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVR 840
Query: 1314 PSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAE 1373
SP +P+P R +P S L G P P +R SV P+
Sbjct: 841 TSPSVTPTPARGTPRSQSFALRA-------RRKGPPPPPP----KRLSSV-----SGPSP 884
Query: 1374 RPLRLQRSPVLK------RRPKLEAPPSPSLGSGLGTEPLPPQPTEPSS--------PER 1419
P L SP K RR L P PS P PP P P+S PE
Sbjct: 885 EPPPLDESPGPKEGATGPRRRTLSEPAGPS------EPPGPPAPAGPASDTEEEEPGPEG 938
Query: 1420 SPPSPATDQRG 1430
+PPS + G
Sbjct: 939 TPPSRGSSGEG 949
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 63.5 bits (153), Expect = 1e-09
Identities = 126/563 (22%), Positives = 175/563 (31%), Gaps = 65/563 (11%)
Query: 903 TMPPALPAPDGGE-PSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFIH 961
T P P+P G PS + P +G+ P ++ + P K + P +
Sbjct: 853 THSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALS 912
Query: 962 SAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTR 1021
+ + P+ A P P A PS +G+P+P A PP+ P P P
Sbjct: 913 MTS--SSPKKARATPAPKGIP-ASPSPKGAPTPPAATPPS-PKGGPATPSPKWAPTPPAA 968
Query: 1022 ARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVD-EGVEEFFSKRLIQQDRLWAPEED 1080
P P+ P G P P A P G A +G + +P
Sbjct: 969 TPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPT--PPAVTPPSPKGSPAAT 1026
Query: 1081 PATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLET--SPGAAPRTRKTTFGDLLRP 1138
P +G +TP T G+ A P+ P T T SP P T L
Sbjct: 1027 PFPKGASTPPAATPPSPKGSPAATPLPKGA--PTTPAATLPSPKGGPATPS-----LKGA 1079
Query: 1139 PTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEAT----------- 1187
PT P+ +G ++P P G P + P + A
Sbjct: 1080 PTPPAATPP--SPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPK 1137
Query: 1188 --LGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAG 1245
L P K P T +P +G+ S G +
Sbjct: 1138 GGLATPPPKGAPTTPAATPPSPKGGLATPP-------PKGAPTTPAATPPSPKGGLATPS 1190
Query: 1246 SDGDIMDSSTEAP--------PISIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLN 1297
G + P P + T + PS + G + P+ A +
Sbjct: 1191 PKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPS 1250
Query: 1298 AELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAG 1357
+ GP P P +P+P +P GL P G N P P G
Sbjct: 1251 PK---------GGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSP--KG 1299
Query: 1358 RRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPLPPQ------- 1410
A S + PA P + SP PP+ + S GT LP
Sbjct: 1300 GPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGG 1359
Query: 1411 PTEPSSPERSPPSPATDQRGGGP 1433
PT PSS E P AT GGP
Sbjct: 1360 PTTPSSKEGPTPPAATPSHKGGP 1382
Score = 60.8 bits (146), Expect = 9e-09
Identities = 130/538 (24%), Positives = 171/538 (31%), Gaps = 109/538 (20%)
Query: 907 ALPAPDGGE--PSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFIHSAA 964
A P+P G P+ P GL P K +PP G P
Sbjct: 1210 ATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSP-----KGGPATP-----P 1259
Query: 965 EEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARP 1024
+ P P A P A P +G+P+PA PP+ P G P P P
Sbjct: 1260 PKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTP-PAATPP 1318
Query: 1025 RPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDPATE 1084
P+ PP G P P P G P P+++
Sbjct: 1319 SPKGSPGTPPPKGAPTPPAVTPPSPKGTPT---------------------LPATTPSSK 1357
Query: 1085 GGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSR 1144
GG T P S GP T P A P + G + PP+ P R
Sbjct: 1358 GGPTT-----------------PSSKEGP-----TPPAATPSHKG---GPAMTPPS-PKR 1391
Query: 1145 GEELGGAEGDTSSP-----DPAGRSRPRYTRDSKAYSM---ILLPAEEEATLGARPDKRR 1196
G + +GD +SP P TR+ A + PA +L P
Sbjct: 1392 GPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSA 1451
Query: 1197 PLERGETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQ-SKDGEIKKAGSDGDIMDSST 1255
P T PS + + V+ S KQ + KKA + M + T
Sbjct: 1452 PKGGPAT---PSSKGDPTLP----AVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPT 1504
Query: 1256 EAPPISIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPS 1315
P I S V A PS R + P + T L ++ A L + PS
Sbjct: 1505 L--PAVIPSSPKEVPATPSSR-----RDPIAPTATLLSKKTPATLAPKEALIPPAMTVPS 1557
Query: 1316 PGQSPS---PCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPA 1372
P ++P+ P +P S P + P G P+ L S +P
Sbjct: 1558 PKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTS------PSPK 1611
Query: 1373 ERPLRLQRSPVLKRRPKLEAPPSPSLGSGL----GTEPLPPQPTEPSSPERSPPSPAT 1426
E P P PPSP G GT PP PSS + SP SPA+
Sbjct: 1612 EAPT-----------PPAVTPPSPEKGPATPAPKGTPTSPP--VTPSSLKDSPTSPAS 1656
Score = 57.0 bits (136), Expect = 1e-07
Identities = 131/553 (23%), Positives = 171/553 (30%), Gaps = 133/553 (24%)
Query: 905 PPALPAPDGGE--PSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFIHS 962
P A P P G P+ P G P K +PP P G P
Sbjct: 1047 PAATPLPKGAPTTPAATLPSPKGGPATPSLKGAP-----TPPAATPPSPKGGPATP---- 1097
Query: 963 AAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRA 1022
+ + P P A P A P +G+P+ A PP+ P G P P
Sbjct: 1098 -SPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTT-PAAT 1155
Query: 1023 RPRPRRQHHHRPPPGGPQVPPAL-PQEGNGLSARVDEGVEEFFSKR-------LIQQDRL 1074
P P+ PP G P P A P GL+ +G + L
Sbjct: 1156 PPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPK 1215
Query: 1075 WAPEEDPAT----EGG-ATPVPRTLRKKLGTLFAFKKPRSTRGPRT----DLETSPGAAP 1125
AP AT +GG ATP P K T A P GP T T P A P
Sbjct: 1216 GAPTTPAATPPSPKGGLATPSP----KGAPTTPAATPPSPKGGPATPPPKGAPTPPAATP 1271
Query: 1126 RTRKTTFGDLLRPPTR----PSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLP 1181
+ K G L PP + P+ G +SP + P T P
Sbjct: 1272 PSLK---GGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAAT-----------P 1317
Query: 1182 AEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEI 1241
+ + G P K P T +P +G+ SK G
Sbjct: 1318 PSPKGSPGTPPPKGAPTPPAVTPPSP----------------KGTPTLPATTPSSKGGPT 1361
Query: 1242 KKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELR 1301
+ +G PP +A PS + GP P
Sbjct: 1362 TPSSKEG-------PTPP----------AATPSHKGGPAMTPP----------------- 1387
Query: 1302 SRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAV 1361
+ GP PSP P TSP+ L + P P +G P
Sbjct: 1388 ----SPKRGPAIPSPKGDP----TSPAVIPLSPKKAPAT-PVTREGAATP---------- 1428
Query: 1362 SVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTEP------- 1414
+ L PA P+ L+++P A PS S G PP P EP
Sbjct: 1429 --SKGDLTPPAVTPVSLKKAPATSAPKGGPATPS-SKGDPTLPAVTPPSPKEPPAPKQVA 1485
Query: 1415 --SSPERSPPSPA 1425
SSP+++P +PA
Sbjct: 1486 TSSSPKKAPATPA 1498
Score = 48.1 bits (113), Expect = 6e-05
Identities = 127/575 (22%), Positives = 189/575 (32%), Gaps = 126/575 (21%)
Query: 901 TVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFI 960
T+ +P + P PD + L L + FP +K+ + + L PF
Sbjct: 500 TLRIPVSPPLPDPEDLKNLPSSVL--VKFPTQKDLQT------------VPASLEGAPFS 545
Query: 961 HSAAEEAEPEPELAAPGEDAEPQAGPSARG-SPSPAAPGPPAGPLPRMDL--PLAGQPLR 1017
+ A + P A P+ PS + S SP P P L + L PL P+
Sbjct: 546 PAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPL---PIG 602
Query: 1018 HPTRARPRP----------RRQHHHRPPPGGPQVPPAL--------PQEGN---GLSARV 1056
P + P + + P GP + +L P E G++
Sbjct: 603 KPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTT 662
Query: 1057 DEGVEEFFSKR--LIQQDRLWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPR 1114
+G + + ++ AP+ P EG T +P A P++T P
Sbjct: 663 AKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVA-PSPQNTCAPL 721
Query: 1115 TDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKA 1174
L AP K+ L P P +++ G ++ A + T DS A
Sbjct: 722 ATLVL----APEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGA 777
Query: 1175 YSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRK 1234
+ A + TL D PL GVS + KR
Sbjct: 778 SAT----ASSKGTLTYLADSPSPL----------------------GVSVSP---QTKRP 808
Query: 1235 QSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQ 1294
+K G AG D I + S+ P+ + + + P +
Sbjct: 809 PTKKGS---AGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATT------------ 853
Query: 1295 QLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSP-SPDSLGLP--EDPCLG----PRNEDG 1347
P PPSP +P+P +P SP + LP E P P ++G
Sbjct: 854 --------------HSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEG 899
Query: 1348 QLRPRPLSAGRRAV--SVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTE 1405
P P A ++ S + PA + + SP P PPSP G
Sbjct: 900 PATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGG------ 953
Query: 1406 PLPPQPT-EPSSPERSPPS----PATDQRGGGPNP 1435
P P P P+ P +PPS PAT G P P
Sbjct: 954 PATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTP 988
Score = 47.4 bits (111), Expect = 1e-04
Identities = 117/496 (23%), Positives = 155/496 (31%), Gaps = 95/496 (19%)
Query: 969 PEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRR 1028
PE L+ G P + SP P P P P PL+ + + P + P P
Sbjct: 837 PENSLSFQGSKDSPAT------THSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSV 890
Query: 1029 QHHHRPPPG----GPQVPPALPQEGN----GLSARVDEGVEEFFSKRLIQQDRLWAPEED 1080
+ P G P+ PAL + + +G+ S + P
Sbjct: 891 VNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATP--- 947
Query: 1081 PATEGG-ATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPP 1139
P+ +GG ATP P K T A P GP T SP AP T PP
Sbjct: 948 PSPKGGPATPSP----KWAPTPPAATPPSPKGGPAT---PSPKGAPTPPAAT------PP 994
Query: 1140 TRPSRGEELGGAEGDTSSPDPAGR-SRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPL 1198
+ +G ++P P G + P T S S P + A+ P P
Sbjct: 995 S----------PKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGAS--TPPAATPPS 1042
Query: 1199 ERGETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAP 1258
+G P + +G+ S G G S AP
Sbjct: 1043 PKGSPAATP--------------LPKGAPTTPAATLPSPKG--------GPATPSLKGAP 1080
Query: 1259 PISIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLN-----AELRSRGWGQQDGPGP 1313
T + PS + GP + P+ A + A +G P
Sbjct: 1081 -------TPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATP 1133
Query: 1314 PSP----------GQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSV 1363
PSP G +P T PSP GL P G P P G A
Sbjct: 1134 PSPKGGLATPPPKGAPTTPAATPPSPKG-GLATPPPKGAPTTPAATPPSP--KGGLATPS 1190
Query: 1364 HEDQLQAPAERPLRLQ---RSPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTEPSSPERS 1420
+ PA P + +P K P A PS GL T PT P++ S
Sbjct: 1191 PKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPS 1250
Query: 1421 PP-SPATDQRGGGPNP 1435
P PAT G P P
Sbjct: 1251 PKGGPATPPPKGAPTP 1266
Score = 39.7 bits (91), Expect = 0.021
Identities = 75/324 (23%), Positives = 109/324 (33%), Gaps = 70/324 (21%)
Query: 898 QQATVTMPPALPAPDG-----GEPSLLEPGELEGLFFPEEKEEEKE---KDDSPPQKWPE 949
++++ T PP P P G S + P L P +K+ K KD S K P
Sbjct: 1707 KKSSATSPPICPDPSAKNGSKGPLSTVAPAPL----LPVQKDSSKTAKGKDASHSPKGPL 1762
Query: 950 LS-HGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAP----------- 997
P +A E+ P+PE A+ P SP P P
Sbjct: 1763 APPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPG 1822
Query: 998 ---GPPAGPLPRMD----LPL-------AGQPLRHPTRARPRPRRQHHHRPPPGGPQVPP 1043
P+ PL D LPL G P + P P+ P P Q P
Sbjct: 1823 LVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQ-PV 1881
Query: 1044 ALPQEGNGLSARVDEGV----EEFFSKRLIQQDRLWAP---EEDPATEG----------- 1085
+G+G + DE V E+ ++ QQ +L A +E+P ++
Sbjct: 1882 TKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARK 1941
Query: 1086 -----------GATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGD 1134
G T V T+RK LF KP + P +D G A +
Sbjct: 1942 AMSKLGLRQVTGVTRV--TIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQ 1999
Query: 1135 LLRPPTRPSRGEELGGAEGDTSSP 1158
L +GE + + +T +P
Sbjct: 2000 LAAAEKFKVQGEAVSNIQENTQTP 2023
Score = 34.7 bits (78), Expect = 0.68
Identities = 64/300 (21%), Positives = 100/300 (33%), Gaps = 65/300 (21%)
Query: 904 MPPALPAPDGGE-PSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHG------LHL 956
+PPA+ P + P++ P E P KE SPP P G L +
Sbjct: 1549 IPPAMTVPSPKKTPAIPTPKEAPAT--PSSKEAS-----SPPAVTPSTYKGAPSPKELLI 1601
Query: 957 VPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPL 1016
P + S + + P P P + A P+ +G+P+ PP P D P +
Sbjct: 1602 PPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPT----SPPVTPSSLKDSPTS---- 1653
Query: 1017 RHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWA 1076
P ++ +PQ GL A+ + L+ A
Sbjct: 1654 -----------------PASVTCKMGATVPQASKGLPAKKGPTA---LKEVLVAP----A 1689
Query: 1077 PEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLL 1136
PE P P+T + + P + G + L T AP
Sbjct: 1690 PESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLST---VAP----------- 1735
Query: 1137 RPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMI----LLPAEEEATLGARP 1192
P P + + A+G +S P G P ++ S + +LP E A++ A P
Sbjct: 1736 -APLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAP 1794
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 61.6 bits (148), Expect = 5e-09
Identities = 82/286 (28%), Positives = 122/286 (42%), Gaps = 19/286 (6%)
Query: 247 LEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGAL 306
LE L L+ C L +++Q L +S L+ LSLAGN + D+G+ LS L AL
Sbjct: 868 LESLRLDCCGLTHACYLKISQILT--TSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCAL 925
Query: 307 RRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNPGALGASEDSGGLYSFLSRP 366
++L L G+T G ++L AL +N +LTHL LS N +LG +E L + P
Sbjct: 926 QKLILEDCGITATGCQSLASALVSN----RSLTHLCLSNN--SLG-NEGVNLLCRSMRLP 978
Query: 367 NVLSFLNLAGTDTALDTVRGCSVGGWMTGRADWRAGRGGLGPPAGVANSLPPQLFAAVSR 426
+ S L LDT GC G++ + L +L V R
Sbjct: 979 H-CSLQRLMLNQCHLDTA-GC---GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMR 1033
Query: 427 GCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDALRALLDGL 486
L L+ + + A +L +SR+R L+ L L L + AL +GL
Sbjct: 1034 EPSCHLQDLE----LVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGL 1089
Query: 487 ALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGAVSSLDLADNGF 532
+ L L AC L S + + + ++SL+L N F
Sbjct: 1090 KQKNSVL-ARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNF 1134
Score = 52.4 bits (124), Expect = 3e-06
Identities = 79/357 (22%), Positives = 130/357 (36%), Gaps = 77/357 (21%)
Query: 306 LRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNPGALGASEDSGGLYSFLSR 365
LR+L L + LT R M+ L L TL + PG L+ +
Sbjct: 783 LRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQH-------LWRIVMA 835
Query: 366 PNVLSFLNLAGTDTALDTVRGCSVGGWMTGRADWRAGRGGLGPPAGVANSLPPQLFAAVS 425
L LNL GT + VR A A P L ++
Sbjct: 836 NRNLRSLNLGGTHLKEEDVR-----------------------MACEALKHPKCLLESLR 872
Query: 426 RGCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDALRALLDG 485
CC LTH A + L+ + +L+ L LAG K+ + L D
Sbjct: 873 LDCC-GLTH--------------ACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDA 917
Query: 486 LALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGAVSSLDLADNGFGSDMVTLVLAIGR 545
L ++ L L C + + G Q + + +++ L L++N G++ V L+ R
Sbjct: 918 LRVSQCALQ-KLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLC---R 973
Query: 546 SRSLRHVALGRNFNVRC---------------------------KETLDDVLHRIVQLMQ 578
S L H +L R +C D+ + + ++M+
Sbjct: 974 SMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMR 1033
Query: 579 DDDCPLQSLSVAESRLKLGASVLLRA-LATNPNLTALDISGNAMGDAGAKLLAKALR 634
+ C LQ L + + L L ++ + +L +LD++ NA+GD G L + L+
Sbjct: 1034 EPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLK 1090
Score = 40.8 bits (94), Expect = 0.009
Identities = 47/195 (24%), Positives = 85/195 (43%), Gaps = 11/195 (5%)
Query: 556 RNFNVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRLKLGASVLL-RALATNPNLTAL 614
R+ N+ ++ + + ++ C L+SL + L + + + L T+P+L +L
Sbjct: 840 RSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSL 899
Query: 615 DISGNAMGDAGAKLLAKALRVNS-RLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLP 673
++GN + D G L+ ALRV+ L+ ++ + +A G +A AL N SL + L
Sbjct: 900 SLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLS 959
Query: 674 LNDVAQAQRSRPELTARAVH-QIQACLLRNNRADPASSDH-------TTRLQPLGLVSDP 725
N + + + R H +Q +L D A + L L L +P
Sbjct: 960 NNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNP 1019
Query: 726 SEQE-VNELCQSVQE 739
E V LC+ ++E
Sbjct: 1020 VEDNGVKLLCEVMRE 1034
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
Length = 816
Score = 59.7 bits (143), Expect = 2e-08
Identities = 125/503 (24%), Positives = 160/503 (31%), Gaps = 86/503 (17%)
Query: 965 EEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAG-------------PLPRMDLPL 1011
++A+ P A P GSP P P PA PL +
Sbjct: 6 DKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGI 65
Query: 1012 AGQ------PLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFS 1065
G P PTR P R PP P + G S G
Sbjct: 66 GGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRA-SGTTRPGP----- 119
Query: 1066 KRLIQQDRLWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAP 1125
+ Q L E+ G AT P+ G R T GP T SP A
Sbjct: 120 ---LGQKGLRISAEETVARGKATEAPKRSALSAGAR------RDTSGP-TPGTPSPAMAR 169
Query: 1126 RTRKTTFGDLL---------RPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYS 1176
R+R L RPPT R +E T+ P PA R RP A
Sbjct: 170 RSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRP------SAGG 223
Query: 1177 MILLPA----EEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAEGK 1232
+ PA AT + P + P RG T AP+ + + G +
Sbjct: 224 GLQRPASRSLSSSATPLSSPARSGPSARG-TPRAPAHPSQPK-----------PKGLQAL 271
Query: 1233 RKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCR--PGPGSQGPESATWK 1290
R K A + SS A P S S SA PS + P P + P AT
Sbjct: 272 RPPQVTPPRKDAAPALGPLSSSPLATP--SPSAPPSPSAPPSLQTLPSPPATPPSQAT-T 328
Query: 1291 TLG----QQLNAELRSRGWGQQDGPGPPS-PGQSPSPCRTSPSPDSLGLPEDPCLGPRNE 1345
+LG Q ++ L S P P + P + P + PSP P P L P
Sbjct: 329 SLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-----PASPPLSP--- 380
Query: 1346 DGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTE 1405
P P + AV + + P P++ SP A P L
Sbjct: 381 --LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP 438
Query: 1406 PLPPQPTEPSSPERSPPSPATDQ 1428
PL P+ P+SP SP + Q
Sbjct: 439 PLQVPPSPPASPPMSPSATPPPQ 461
Score = 40.0 bits (92), Expect = 0.016
Identities = 59/223 (26%), Positives = 78/223 (34%), Gaps = 42/223 (18%)
Query: 958 PFIHSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLR 1017
P SA ++ P LAAP P P A SP+A PP P P PL Q +
Sbjct: 420 PVSPSATPPSQAPPSLAAPPLQVPP--SPPASPPMSPSATPPPQAPPPLAAPPL--QLAK 475
Query: 1018 HPTRARP---RPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRL 1074
P +A P P Q PP P P P +S + + ++ L
Sbjct: 476 PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ---APPVLAAPLL 532
Query: 1075 WAPEEDPATEGGATPVPRTLRKKLGTLFAFKKP------RSTRGPRTDLETSPGAAPRTR 1128
P PA+ TL A ++P S GPR L +PG P
Sbjct: 533 QVPPSPPASP---------------TLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 577
Query: 1129 KTTFGDLLRP------PTRPSRGEELGGAE-----GDTSSPDP 1160
++ L P + S EEL G + G +SP P
Sbjct: 578 RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPP 620
Score = 35.0 bits (79), Expect = 0.52
Identities = 110/529 (20%), Positives = 150/529 (28%), Gaps = 112/529 (21%)
Query: 979 DAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGG 1038
++ P+AGP+ P + G A P P R RP P Q
Sbjct: 72 ESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQ--------- 122
Query: 1039 PQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWA-PEEDPATEGGATPVPRTLRKK 1097
GL +E V + ++ L A D + TP P R+
Sbjct: 123 -----------KGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 171
Query: 1098 --LGTLFAFKKPRSTRGPRTDLE--------------TSPGAAPRTRKTTFGDLLRPPTR 1141
GT +P + PR E T P A R R + G L RP +R
Sbjct: 172 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 231
Query: 1142 PSRGEELGGAEGDTSSPDPAGRSR-PRYTRDSKAYSMILL------PAEEEATLGARPDK 1194
+ S P G R P + K + L P ++A P
Sbjct: 232 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 291
Query: 1195 RRPLERGETEL--APSFEQRVQVMLQ-------RIGVSRGSGGAEGKRKQSKDGEIKKAG 1245
PL +PS +Q + + S GS + +
Sbjct: 292 SSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA 351
Query: 1246 SDGDIMDSSTEAPPISIKSRTHSVSADPSCRP--GPGSQGPESATWKTLGQQLNAELRSR 1303
+ + PP+ S A P P P Q P + L +
Sbjct: 352 TPPPQAPPALALPPLQAPP---SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP 408
Query: 1304 GWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPE---------DPCLGPRNEDGQLRPRPL 1354
Q P SP SPS S +P SL P P + P P PL
Sbjct: 409 V--QAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPL 466
Query: 1355 SAGRRAVSVHEDQL---------------------QAPAERPLRLQRSPVLKRRPK---- 1389
+A ++ Q QAP L SP+ P+
Sbjct: 467 AAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV 526
Query: 1390 -----LEAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPSPATDQRGGGP 1433
L+ PPSP P PT R PP+P D GP
Sbjct: 527 LAAPLLQVPPSP-----------PASPT--LQAPRRPPTPGPDTSVSGP 562
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 59.3 bits (142), Expect = 3e-08
Identities = 130/548 (23%), Positives = 190/548 (34%), Gaps = 95/548 (17%)
Query: 930 PEEKEEEKE------KDDSPPQKWPELSHGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQ 983
PE+KE+ E K P + + + VP E EP PE + E + +
Sbjct: 214 PEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEK 273
Query: 984 AGPSARG---SPSPAAPGPPAGPLPRM---DLPLAGQPLRHPT-RARPRPRRQHHHRPPP 1036
P +R S S P+ PR + P R P+ R RP PRR R PP
Sbjct: 274 TRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRR----RTPP 329
Query: 1037 GGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDPATEGGATPVPRTLRK 1096
PP + + + R S R +P + P + P R R+
Sbjct: 330 RRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPP--RKTRR 387
Query: 1097 KLGTLFAFKK-----PRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGA 1151
+ ++ P +T P+T +P + RTRK+ + P + + G
Sbjct: 388 LSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVS--VSPGRTSGKVTKHKGT 445
Query: 1152 EGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQ 1211
E SP PA + R + L +EE+ + G+ A S +Q
Sbjct: 446 E-KRESPSPAPKPR----------KVELSESEED-------------KGGKMAAADSVQQ 481
Query: 1212 RVQVMLQRIGVSRGSGGAEG------KRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSR 1265
R Q Q S SG + KR K+GE+ + +
Sbjct: 482 RRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRR------------------RRH 523
Query: 1266 THSVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWG----QQDGPGPPSPGQSPS 1321
+ S SA PS R P ++ RS ++ P PP ++PS
Sbjct: 524 SPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPS 583
Query: 1322 PC--RTSPSPDSLGLP----EDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERP 1375
P R SPSP P P P+ P P RRA + + P
Sbjct: 584 PPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPP---KRRASPSPPPKRRVSHSPP 640
Query: 1376 LRLQRSPVLKRR-PKLEAP----PSPSLGSGLGTEPLPPQPTEPSSPERSP---PSPATD 1427
+ + SPV KRR P L + SPS + P P + PS R+P SP
Sbjct: 641 PKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPV 700
Query: 1428 QRGGGPNP 1435
+RG +P
Sbjct: 701 RRGASSSP 708
Score = 47.0 bits (110), Expect = 1e-04
Identities = 111/518 (21%), Positives = 164/518 (31%), Gaps = 108/518 (20%)
Query: 938 EKDDSPPQKWPELSHGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAP 997
++ SPP+K LS H + A P P+ PQ R S +P
Sbjct: 376 KRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTR---HSPTPQQSNRTRKSRVSVSP 432
Query: 998 GPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQH--HHRPPPGGPQVPPALPQEGNGLSAR 1055
G +G + + G R P+PR+ GG Q+ +
Sbjct: 433 GRTSGKVTKHK----GTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQ 488
Query: 1056 VDEGVEEFFSKRLIQQDRLWAPEEDPATEG------------GATPVPRTLRKKLGTLFA 1103
+ + S + +R P+ G A+P PR +K+ T
Sbjct: 489 NQQSSSDSGSSSSSEDER---PKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKE--TSPR 543
Query: 1104 FKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPAGR 1163
++ RS P T SP AP R+ R PT P R T SP P R
Sbjct: 544 GRRRRSPSPPPTRRRRSPSPAPPPRRR------RTPTPPPRRR--------TPSPPPRRR 589
Query: 1164 SRP--RYTRDSKAYSMILLPAEEEATLGARPDKRR----PLERGETELAPSFEQRVQVML 1217
S RY+ + P + P KRR P + +P +QR +
Sbjct: 590 SPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVT 649
Query: 1218 QRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRP 1277
+R R S + +K S + P ++ HS P
Sbjct: 650 KR-------------RSPSLSSKHRKGSSPSRSTREARSPQP----NKRHS--------P 684
Query: 1278 GPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRT-SPSPDSLGLPE 1336
P + P++++ P P G S SP R SPSP + +
Sbjct: 685 SPRPRAPQTSS---------------------SPPPVRRGASSSPQRRQSPSPSTRPIRR 723
Query: 1337 DPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSP 1396
P P + A + + + R + P K+ P APPSP
Sbjct: 724 V----------SRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPP---APPSP 770
Query: 1397 SLGSGLGTEPLPPQPTEPSSPERSPPSPA--TDQRGGG 1432
T P P + + PSP +DQ GGG
Sbjct: 771 VQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGG 808
Score = 32.7 bits (73), Expect = 2.6
Identities = 38/157 (24%), Positives = 60/157 (38%), Gaps = 16/157 (10%)
Query: 969 PEPELAAPGEDAEPQA------GPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRA 1022
PEP+ PQ+ S GSP PAA PPA P P + P + + A
Sbjct: 728 PEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQ----SQSPSTNWSPA 783
Query: 1023 RPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDPA 1082
P + + P P P QEG G + + + K+ ++ + E+ A
Sbjct: 784 VPVKKA----KSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKK-HKKHKKHKKEKAVA 838
Query: 1083 TEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLET 1119
A P + TL A ++P + P+ + E+
Sbjct: 839 AAAAAAVTPAAIAAATTTL-AQEEPVAAPEPKKETES 874
>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
Length = 416
Score = 57.8 bits (138), Expect = 7e-08
Identities = 113/472 (23%), Positives = 139/472 (29%), Gaps = 124/472 (26%)
Query: 968 EPEPELAAPG-EDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRP 1026
E P L A + A PQ G +G PSP PG P GP P+ G P
Sbjct: 26 EESPSLIAGNPQGAPPQGGNKPQGPPSP--PGKPQGPPPQGGNQPQGPP----------- 72
Query: 1027 RRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDPATEGG 1086
PPPG PQ PP PQ GN G + P +G
Sbjct: 73 -------PPPGKPQGPP--PQGGNKPQGPPPPG-----------------KPQGPPPQGD 106
Query: 1087 ATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGE 1146
+ PR+ P +GP P P PP +G
Sbjct: 107 KSRSPRS------------PPGKPQGPPPQGGNQPQGPP------------PPPGKPQGP 142
Query: 1147 ELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELA 1206
G P P P D+K+ S P + + P + G
Sbjct: 143 PPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGP---------PPQGGNQPQG 193
Query: 1207 PSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAG--SDGDIMDSSTEAPPISIKS 1264
P G +G G + Q K G GD S +PP
Sbjct: 194 PP---------PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPP----- 239
Query: 1265 RTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCR 1324
P + G QGP K G +G + GP PP Q P P
Sbjct: 240 ---GKPQGPPPQGGNQPQGPPPPPGKPQGPP------PQGGNKPQGPPPPGKPQGPPPQG 290
Query: 1325 TSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVL 1384
S S S P P GP + G +Q Q P P + Q P
Sbjct: 291 GSKSRSSRSPPGKP-QGPPPQGG------------------NQPQGPPPPPGKPQ-GPPP 330
Query: 1385 KRRPKLEAPPSPSLGSGLGTEPLPPQPTEPSSPERSPP-SPATDQRGGGPNP 1435
+ K + PP P G PPQ S RSPP P + G NP
Sbjct: 331 QGGNKPQGPPPPGKPQG-----PPPQGGSKSRSARSPPGKPQGPPQQEGNNP 377
Score = 40.4 bits (93), Expect = 0.012
Identities = 45/149 (30%), Positives = 57/149 (38%), Gaps = 27/149 (18%)
Query: 906 PALPAPDGGEPSLLE---PGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFIHS 962
P P P GG S PG+ +G P + + + PP P+ P
Sbjct: 283 PQGPPPQGGSKSRSSRSPPGKPQG---PPPQGGNQPQGPPPPPGKPQ-------GPPPQG 332
Query: 963 AAEEAEPEPELAAPG--EDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPT 1020
+ P P PG + PQ G +R + SP PG P GP P+ + P P
Sbjct: 333 GNKPQGPPP----PGKPQGPPPQGGSKSRSARSP--PGKPQGP-PQQE---GNNPQGPPP 382
Query: 1021 RARPRPRRQHHHRPPPGGPQVPPALPQEG 1049
A P Q PP G PQ PP PQ G
Sbjct: 383 PAGGNP--QQPQAPPAGQPQGPPRPPQGG 409
Score = 38.1 bits (87), Expect = 0.061
Identities = 46/171 (26%), Positives = 62/171 (36%), Gaps = 43/171 (25%)
Query: 906 PALPAPDGGEPSL--LEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFIHSA 963
P P P GG PG+ +G P + + + SPP K P+ P
Sbjct: 139 PQGPPPQGGNKPQGPPPPGKPQGP--PPQGDNKSRSSRSPPGK-PQ-------GPPPQGG 188
Query: 964 AEEAEPEPELAAPGEDAEPQAGPSARGSPSP------------------AAPGPPAGP-- 1003
+ P P P + PQ G +G P P + PG P GP
Sbjct: 189 NQPQGPPPPPGKP-QGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPP 247
Query: 1004 ----LPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGN 1050
P+ P G+P P + +P+ PPPG PQ PP PQ G+
Sbjct: 248 QGGNQPQGPPPPPGKPQGPPPQGGNKPQGP----PPPGKPQGPP--PQGGS 292
Score = 34.7 bits (78), Expect = 0.68
Identities = 26/72 (36%), Positives = 31/72 (43%), Gaps = 16/72 (22%)
Query: 974 AAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRM-DLPLAGQPLRHPTRARPRPRRQHHH 1032
+A +PQ P G+ +P P PPAG P+ P AGQP P
Sbjct: 358 SARSPPGKPQGPPQQEGN-NPQGPPPPAGGNPQQPQAPPAGQPQGPP------------- 403
Query: 1033 RPPPGG-PQVPP 1043
RPP GG P PP
Sbjct: 404 RPPQGGRPSRPP 415
>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
Length = 1094
Score = 57.8 bits (138), Expect = 7e-08
Identities = 63/211 (29%), Positives = 87/211 (41%), Gaps = 43/211 (20%)
Query: 1257 APPISIKS--RTHSVSADPSCRPGPGSQGPESA--TWK---------TLGQQLNAELRSR 1303
A P S++S R SVS+ P P S+ P S+ TW + G L+++ S
Sbjct: 385 ASPASVRSLGRFSSVSS-----PQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSE 439
Query: 1304 GWGQQDGPG-----PPSPGQ---SPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLS 1355
G + PP G SPS T+ + D+L + L R+ + RP
Sbjct: 440 GQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPP 499
Query: 1356 AGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTE-- 1413
RR S+H+ L P + PL L P K++P+L PP+ G G P PP P
Sbjct: 500 PPRRTHSLHQRGLAVP-DGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSW 558
Query: 1414 ------------PSSPER--SPPSPATDQRG 1430
P SPER SP S + Q G
Sbjct: 559 VPGLSPGGSRRPPRSPERTLSPSSGYSSQSG 589
Score = 43.5 bits (101), Expect = 0.001
Identities = 125/553 (22%), Positives = 183/553 (33%), Gaps = 105/553 (18%)
Query: 897 AQQATVTMPP---ALPAPDGGEPSLLEPGELEGLFFP------------EEKEEEKEKDD 941
+Q T T+PP A P G+ +P + L P + D
Sbjct: 586 SQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDR 645
Query: 942 SPPQKWPELSHGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARGSP-SPAAPGPP 1000
S PQ L + P A + P + +P A A P+ P S P
Sbjct: 646 SGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQ 705
Query: 1001 AGPLPRMDL-PLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEG 1059
+ P P+ L PL P+ ++ P +H PPP P P + E S +E
Sbjct: 706 SPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPP--PTKKPEVVVEAPSASETAEEP 763
Query: 1060 VEEFFSKRLIQQDRLWAPEEDPATEG-----GATPVPRTLRKKLGTLFAFKKPRSTRGPR 1114
+ QD W P PA E P P F+ P GP
Sbjct: 764 L----------QDPNWPPPPPPAPEEQDLSMADFPPPEE------AFFSVASPEPA-GPS 806
Query: 1115 --TDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDS 1172
+L +SP A+ + ++PP SPDP S
Sbjct: 807 GSPELVSSPAASSSSATAL---QIQPP----------------GSPDPPPAPPAPAPASS 847
Query: 1173 KAYSMILLPAEEEA--TLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAE 1230
+ LP +E + G P + + G + PS Q V++ S GA
Sbjct: 848 APGHVAKLPQKEPVGCSKGGGPPRE---DVGAPLVTPSLLQMVRLR---------SVGAP 895
Query: 1231 GKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWK 1290
G G+ + S P+ ++S S P P S + K
Sbjct: 896 G-------------GAPTPALGPSAPQKPLR-----RALSGRASPVPAPSSGLHAAVRLK 937
Query: 1291 TLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLR 1350
+ L S Q +GP P SP T+ S G + P + + Q
Sbjct: 938 ACSLAASEGLSS---AQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQAD 994
Query: 1351 -PRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPLPP 1409
R L A R++S QAP + P + P + R+P + PP P+ S EPL
Sbjct: 995 LQRNLVAELRSISEQRPP-QAPKKSP---KAPPPVARKPSVGVPP-PASPSYPRAEPLTA 1049
Query: 1410 QPTE--PSSPERS 1420
PT P + +R+
Sbjct: 1050 PPTNGLPHTQDRT 1062
Score = 32.7 bits (73), Expect = 2.6
Identities = 74/308 (24%), Positives = 106/308 (34%), Gaps = 56/308 (18%)
Query: 1140 TRPSRGEELGGAEGDTSS-----PDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDK 1194
T S+G G E T+S P G R + S A + L L R
Sbjct: 431 TLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVS 490
Query: 1195 RRPLERGETELAPSFEQRVQVMLQR-IGVSRGSGGAEGKRKQSKDGEIKK----AGSDGD 1249
R L+R P +R + QR + V G G K ++ + ++ + GS+G
Sbjct: 491 LRKLKR-----PPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGA 545
Query: 1250 IMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQD 1309
+ PP S P PG GS+ P + +TL S G+ Q
Sbjct: 546 ---GAAPCPPNPANSWV------PGLSPG-GSRRPPRSPERTLSP-------SSGYSSQS 588
Query: 1310 G-PGPPSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQL 1368
G P P G + P SP PE R L + +VS L
Sbjct: 589 GTPTLPPKGLAGPPA--SPGKAQPPKPE-------------RVTSLRSPGASVSSSLTSL 633
Query: 1369 QAPAERPLRLQRSPVLKRRP---KLEAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPSPA 1425
+ + P RS P + PP P + + P P P++P SP + P+ A
Sbjct: 634 CSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPA-----PFSPPPSKPRSPNPAAPALA 688
Query: 1426 TDQRGGGP 1433
GP
Sbjct: 689 APAVVPGP 696
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 57.8 bits (138), Expect = 7e-08
Identities = 135/619 (21%), Positives = 208/619 (33%), Gaps = 140/619 (22%)
Query: 909 PAPDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFIHSAAEEAE 968
P+P G + P L + FP+ +++E+ P + E+ G + + E E
Sbjct: 916 PSPQGTKAPRFVP--LTSICFPDSLLQDEERSFFPTME--EMFGGGAADDYGKAGPPEDE 971
Query: 969 PEPELAA---PGEDAEPQAGPSARGSPSPAAPGPPAGPL-----PRMDLPLAGQPL---- 1016
+P+ A PG A GP G S A P P L P + + +PL
Sbjct: 972 GDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQ 1031
Query: 1017 RHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARV-----DEGVEEFFSKRLIQQ 1071
P +A P P PPP P PA +G GL++ + + + + S L+++
Sbjct: 1032 SGPHQAAPPP-------PPPPPPPPAPASEPKG-GLTSPIFCSTKPKKLLKTSSFHLLRR 1083
Query: 1072 --------DRLWAPEEDPATEGGATPVPRTLR---KKLGTLFAFKKPRSTRGPRTDLETS 1120
+L+A E + + VP +R ++L L + + R P D++
Sbjct: 1084 RDPPFQTPKKLYAQEYEFEADEDKADVPADIRLNPRRLPDLVSSCRSRPALSPLGDIDFC 1143
Query: 1121 P------GAAPRTRKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKA 1174
P G R RK T PP RP + E T++ PA S P
Sbjct: 1144 PPNPGPDGPRRRGRKPTKAKRDGPP-RPRGRPRIRPLEVPTTA-GPASASTPT------- 1194
Query: 1175 YSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAEG--- 1231
++ R R+ E G T L P ++++ + + G G+ +
Sbjct: 1195 ------DGAKKPRGRGRGRGRKAEEAGGTRLEPLKPLKIKLSVPKAGEGLGTSSGDAISG 1248
Query: 1232 -------------------KRKQSKDGEIKKA--GSDGDIMDSSTEAPPISIKSRTHSVS 1270
K + K E+K S D + S PP+ T +S
Sbjct: 1249 TDHNSLDSSLTREKIEAKIKEVEEKQPEMKSGFMASFLDFLKSGKRHPPLYQAGLTPPLS 1308
Query: 1271 ADPSCRPGPGSQG--------------PESATWKTLGQQLNAELRSRGWGQQDGPGPPSP 1316
S P ++G P S + G AE G G
Sbjct: 1309 PPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEAAESEGLGLG---------- 1358
Query: 1317 GQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLS---------------AGRRAV 1361
PSPC+ L P ED + R L AG +
Sbjct: 1359 --CPSPCKRLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDT 1416
Query: 1362 SVHEDQLQAPAER-----PLR---------LQRSPVLKRRPKLEAPPSPSLGSGLGTEPL 1407
S + APA PL P+L+ +P PP+P+ P
Sbjct: 1417 STPDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPP 1476
Query: 1408 PPQPTEPSSPERSPPSPAT 1426
PPQP PS P P+P++
Sbjct: 1477 PPQPALPSPPPLVAPTPSS 1495
Score = 42.7 bits (99), Expect = 0.002
Identities = 116/523 (22%), Positives = 164/523 (31%), Gaps = 113/523 (21%)
Query: 856 QDAFTRLRDMRLSITGTLAESIVAQALAGLSAARDQLVESLAQQATVTMPPALPA-PDGG 914
+D+ + RD++ SI+ ++ ++ LAG LA A V PP LP P
Sbjct: 1385 EDSVAKNRDLQESISSAIS-ALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSAN 1443
Query: 915 EPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFIHSAAEEAEPEPELA 974
EP LE EK PP P+ P P+P L
Sbjct: 1444 SNGTPEPPLLE----------EKPPPTPPPAPTPQPQPPPPPPP----------PQPALP 1483
Query: 975 APGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRP 1034
+P P PS+ P P PPA P P P A PL P + P
Sbjct: 1484 SPPPLVAPT--PSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPP--------EEPAAP 1533
Query: 1035 PPGGPQVPPALP------QEGNGLSARVDE-----GVEEFFSKR---LIQQDRLWAPEED 1080
P P++P P QE + DE G E F +R +I+ + + P
Sbjct: 1534 SPEDPELPDTRPLHLAKKQETAAVCGETDEEAGESGGEGIFRERDEFVIRAEDI--PSLK 1591
Query: 1081 PATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSP-----GAAPRTRKTTFGDL 1135
A + G P P +K L P G R TS G A + +
Sbjct: 1592 LALQTGREPPPIWRVQK--ALLQKFTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVKF 1649
Query: 1136 L------------------RPPTRPSRGEELGG--AEGDTSSPDPAGRSRPRYTRDSKAY 1175
L RPP R + + G +S+P P + P
Sbjct: 1650 LENVNKKDYVRVCARKPWHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPP-------- 1701
Query: 1176 SMILLPAEEEATLGARPDKRRP---LERGETELAPSFEQRVQVMLQRIGVSRGSGGAEGK 1232
P E T +P ++ P + PS + V+ ++ V+RG G+
Sbjct: 1702 ----KPETPEKTTSEKPPEQTPETAMPEPPAPEKPSLLRPVEKEKEKEKVTRGERPLRGE 1757
Query: 1233 RKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWKTL 1292
R S P S+ + + S P RP P K
Sbjct: 1758 RATS----------------GRQTRPERSLATGQPATSRLPKARPTKVKAEPPPKKRKKW 1801
Query: 1293 GQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLP 1335
L+ G G GPP +PS D +P
Sbjct: 1802 -------LKEAGGNATAGGGPPGSSSDSESSPGAPSEDERAVP 1837
Score = 39.3 bits (90), Expect = 0.028
Identities = 37/119 (31%), Positives = 43/119 (36%), Gaps = 19/119 (15%)
Query: 1309 DGP--GPPSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHED 1366
DGP P + P P PS +S G PE P L + P P A +
Sbjct: 1420 DGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPP-----PTPPPA-----PTPQP 1469
Query: 1367 QLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPSPA 1425
Q P P SP P +PP P L P PP P PS P PP+ A
Sbjct: 1470 QPPPPPPPPQPALPSPPPLVAPTPSSPPPPPL-------PPPPPPAMPSPPPPPPPAAA 1521
Score = 32.7 bits (73), Expect = 2.6
Identities = 48/172 (27%), Positives = 61/172 (35%), Gaps = 35/172 (20%)
Query: 987 SARGS--PSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPA 1044
SA GS P P AP PP P+ + P T +P + P P P+ P
Sbjct: 1685 SAGGSSAPPPKAPAPP----PKPETP------EKTTSEKPPEQTPETAMPEPPAPEKPSL 1734
Query: 1045 L-PQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDPATEGGAT--------------P 1089
L P E +V G +R R PE AT AT P
Sbjct: 1735 LRPVEKEKEKEKVTRGERPLRGER-ATSGRQTRPERSLATGQPATSRLPKARPTKVKAEP 1793
Query: 1090 VPRTLRKKL----GTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLR 1137
P+ +K L G A P G +D E+SPGA + G LL+
Sbjct: 1794 PPKKRKKWLKEAGGNATAGGGP---PGSSSDSESSPGAPSEDERAVPGRLLK 1842
Score = 31.2 bits (69), Expect = 7.5
Identities = 33/106 (31%), Positives = 36/106 (33%), Gaps = 25/106 (23%)
Query: 969 PEPELAAPGEDAEPQAGPSAR-------------GSPSPAAPGPPAGPLPRMDLPLAGQP 1015
P P+L P PSA G+P P P PP P P M L L
Sbjct: 797 PPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPP--PPPPMPLQLEAHL 854
Query: 1016 LRHPTR-ARPRPR-RQHHHRPPPGGPQ--------VPPALPQEGNG 1051
H A P PR R PPG Q +PPA G G
Sbjct: 855 RSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVG 900
>gi|25777608 NLR family member X1 isoform 1 [Homo sapiens]
Length = 975
Score = 57.0 bits (136), Expect = 1e-07
Identities = 55/221 (24%), Positives = 94/221 (42%), Gaps = 38/221 (17%)
Query: 463 TLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGAV 522
+LR L LAG ++ P + L H D ++L++C+L AG + + + A
Sbjct: 697 SLRQLNLAGVRMTPVKCTVVAAVLGSGRHALD-EVNLASCQLDPAGLRTLLPVFLRA--- 752
Query: 523 SSLDLADNGFGSDMVTLVLAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDC 582
L L N G + CK+ D +LH D C
Sbjct: 753 RKLGLQLNSLGPEA-------------------------CKDLRDLLLH--------DQC 779
Query: 583 PLQSLSVAESRLKL-GASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLRS 641
+ +L ++ + L G +VL+ LA N ++T L + +GD G +LLA L N +L+
Sbjct: 780 QITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQE 839
Query: 642 VVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLNDVAQAQR 682
+ N L +A+A ++ SL+ + L N+++ R
Sbjct: 840 LNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGR 880
Score = 37.7 bits (86), Expect = 0.080
Identities = 33/108 (30%), Positives = 52/108 (48%), Gaps = 2/108 (1%)
Query: 451 PAALQLFLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQ 510
PA L+ L R LGL L P+A + L D L L+ + L LS L +AG
Sbjct: 739 PAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRD-LLLHDQCQITTLRLSNNPLTAAGVA 797
Query: 511 VIQDLVCDAGAVSSLDLADNGFGSDMVTLVLA-IGRSRSLRHVALGRN 557
V+ + + +V+ L L G G + + L+ A + R+R L+ + + N
Sbjct: 798 VLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYN 845
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 56.2 bits (134), Expect = 2e-07
Identities = 75/289 (25%), Positives = 125/289 (43%), Gaps = 25/289 (8%)
Query: 420 LFAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDAL 479
LF+ +S SLT LD S N R LQ +R L L C L +
Sbjct: 733 LFSVLSTS--QSLTELDLSDNSLGDPGMRVLCETLQ---HPGCNIRRLWLGRCGLSHECC 787
Query: 480 RALLDGLALNTHLRDLHLDLSACELRSAGAQVI----QDLVCDAGAVSSLDLADNGFGSD 535
+ L L+++ + + LDLS L G +++ + L+C+ + +
Sbjct: 788 FDI--SLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQ 845
Query: 536 MVTLVLAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRL- 594
+ VL+ S SL + +G N D + + + ++ C LQ L + S L
Sbjct: 846 DLASVLST--SHSLTRLYVGEN------ALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 897
Query: 595 KLGASVLLRALATNPNLTALDISGNAMGDAGAKLLAKA-LRVNSRLRSVVWDRNHTSALG 653
+ S L L+TN NLT L + GN +GD G KLL + L + +L+ + D + ++
Sbjct: 898 SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC 957
Query: 654 LLDVAQALEQNHSLKAMPLPLNDVAQAQRSRPELTARAVHQIQACLLRN 702
D++ L + SL+ + L ND+ + V + Q+CLL+N
Sbjct: 958 CWDLSTLLTSSQSLRKLSLGNNDLGDL----GVMMFCEVLKQQSCLLQN 1002
Score = 47.0 bits (110), Expect = 1e-04
Identities = 80/315 (25%), Positives = 121/315 (38%), Gaps = 24/315 (7%)
Query: 257 LRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGALRRLSLAQTGL 316
L F R L L+ +S L EL L+ N L D GM L L+ +RRL L + GL
Sbjct: 725 LTSSFCRGLFSVLS--TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGL 782
Query: 317 TPRGMRALGRALATNAAFDSTLTHLDLSGNP-GALGASEDSGGLYSFLSRPNVLSFLNLA 375
+ + L++N L LDLS N G G GL L L ++
Sbjct: 783 SHECCFDISLVLSSN----QKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCC 838
Query: 376 GTDTALDTVRGCSVGGWMTGRADWRAGRGGLGPPAGVANSLPPQLFAAVSRGCCTSLTHL 435
T + SV G LG +GVA + ++ +L L
Sbjct: 839 LTSACCQDL--ASVLSTSHSLTRLYVGENALG-DSGVA------ILCEKAKNPQCNLQKL 889
Query: 436 DASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDL 495
+ + + +AL LS + L HL L G L ++ L +GL L+ +
Sbjct: 890 ----GLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGL-LHPDCKLQ 944
Query: 496 HLDLSACELRSAGAQVIQDLVCDAGAVSSLDLADNGFGSDMVTLVLAIGRSRSLRHVALG 555
L+L C L S + L+ + ++ L L +N G V + + + +S LG
Sbjct: 945 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
Query: 556 RN---FNVRCKETLD 567
+ FN K L+
Sbjct: 1005 LSEMYFNYETKSALE 1019
Score = 42.7 bits (99), Expect = 0.002
Identities = 34/101 (33%), Positives = 48/101 (47%), Gaps = 6/101 (5%)
Query: 246 HLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGA 305
+L++L L +C L + LA L+ +S L L + N L D G+ L +
Sbjct: 828 NLKKLWLVSCCLTSACCQDLASVLS--TSHSLTRLYVGENALGDSGVAILCEKAKNPQCN 885
Query: 306 LRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGN 346
L++L L +GLT AL L+TN LTHL L GN
Sbjct: 886 LQKLGLVNSGLTSVCCSALSSVLSTN----QNLTHLYLRGN 922
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 56.2 bits (134), Expect = 2e-07
Identities = 75/289 (25%), Positives = 125/289 (43%), Gaps = 25/289 (8%)
Query: 420 LFAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDAL 479
LF+ +S SLT LD S N R LQ +R L L C L +
Sbjct: 733 LFSVLSTS--QSLTELDLSDNSLGDPGMRVLCETLQ---HPGCNIRRLWLGRCGLSHECC 787
Query: 480 RALLDGLALNTHLRDLHLDLSACELRSAGAQVI----QDLVCDAGAVSSLDLADNGFGSD 535
+ L L+++ + + LDLS L G +++ + L+C+ + +
Sbjct: 788 FDI--SLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQ 845
Query: 536 MVTLVLAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRL- 594
+ VL+ S SL + +G N D + + + ++ C LQ L + S L
Sbjct: 846 DLASVLST--SHSLTRLYVGEN------ALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 897
Query: 595 KLGASVLLRALATNPNLTALDISGNAMGDAGAKLLAKA-LRVNSRLRSVVWDRNHTSALG 653
+ S L L+TN NLT L + GN +GD G KLL + L + +L+ + D + ++
Sbjct: 898 SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC 957
Query: 654 LLDVAQALEQNHSLKAMPLPLNDVAQAQRSRPELTARAVHQIQACLLRN 702
D++ L + SL+ + L ND+ + V + Q+CLL+N
Sbjct: 958 CWDLSTLLTSSQSLRKLSLGNNDLGDL----GVMMFCEVLKQQSCLLQN 1002
Score = 47.0 bits (110), Expect = 1e-04
Identities = 80/315 (25%), Positives = 121/315 (38%), Gaps = 24/315 (7%)
Query: 257 LRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGALRRLSLAQTGL 316
L F R L L+ +S L EL L+ N L D GM L L+ +RRL L + GL
Sbjct: 725 LTSSFCRGLFSVLS--TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGL 782
Query: 317 TPRGMRALGRALATNAAFDSTLTHLDLSGNP-GALGASEDSGGLYSFLSRPNVLSFLNLA 375
+ + L++N L LDLS N G G GL L L ++
Sbjct: 783 SHECCFDISLVLSSN----QKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCC 838
Query: 376 GTDTALDTVRGCSVGGWMTGRADWRAGRGGLGPPAGVANSLPPQLFAAVSRGCCTSLTHL 435
T + SV G LG +GVA + ++ +L L
Sbjct: 839 LTSACCQDL--ASVLSTSHSLTRLYVGENALG-DSGVA------ILCEKAKNPQCNLQKL 889
Query: 436 DASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDL 495
+ + + +AL LS + L HL L G L ++ L +GL L+ +
Sbjct: 890 ----GLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGL-LHPDCKLQ 944
Query: 496 HLDLSACELRSAGAQVIQDLVCDAGAVSSLDLADNGFGSDMVTLVLAIGRSRSLRHVALG 555
L+L C L S + L+ + ++ L L +N G V + + + +S LG
Sbjct: 945 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
Query: 556 RN---FNVRCKETLD 567
+ FN K L+
Sbjct: 1005 LSEMYFNYETKSALE 1019
Score = 42.7 bits (99), Expect = 0.002
Identities = 34/101 (33%), Positives = 48/101 (47%), Gaps = 6/101 (5%)
Query: 246 HLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGA 305
+L++L L +C L + LA L+ +S L L + N L D G+ L +
Sbjct: 828 NLKKLWLVSCCLTSACCQDLASVLS--TSHSLTRLYVGENALGDSGVAILCEKAKNPQCN 885
Query: 306 LRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGN 346
L++L L +GLT AL L+TN LTHL L GN
Sbjct: 886 LQKLGLVNSGLTSVCCSALSSVLSTN----QNLTHLYLRGN 922
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 55.1 bits (131), Expect = 5e-07
Identities = 67/264 (25%), Positives = 118/264 (44%), Gaps = 43/264 (16%)
Query: 465 RHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGAVSS 524
RHL + C LP + A GL +N+HL S+ + + ++ + +++
Sbjct: 699 RHLDMVQCVLPSSSHAACSHGL-VNSHLT------------SSFCRGLFSVLSTSQSLTE 745
Query: 525 LDLADNGFGSDMVTLVLAIGRSR--SLRHVALGR-NFNVRCKETLDDVL---HRIVQLMQ 578
LDL+DN G + ++ + ++R + LGR + C + VL ++V+L
Sbjct: 746 LDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDL 805
Query: 579 DDD------------------CPLQSLSVAESRL-KLGASVLLRALATNPNLTALDISGN 619
D+ C L+ L + S L + S L L+TN NLT L + GN
Sbjct: 806 SDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGN 865
Query: 620 AMGDAGAKLLAKA-LRVNSRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLNDVA 678
+GD G KLL + L + +L+ + D + ++ D++ L + SL+ + L ND+
Sbjct: 866 TLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLG 925
Query: 679 QAQRSRPELTARAVHQIQACLLRN 702
+ V + Q+CLL+N
Sbjct: 926 DL----GVMMFCEVLKQQSCLLQN 945
Score = 39.3 bits (90), Expect = 0.028
Identities = 34/101 (33%), Positives = 48/101 (47%), Gaps = 6/101 (5%)
Query: 246 HLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGA 305
++ L L C L + ++ L+ S+ L EL L+ N L D G+ L L+
Sbjct: 771 NIRRLWLGRCGLSHECCFDISLVLS--SNQKLVELDLSDNALGDFGIRLLCVGLKHLLCN 828
Query: 306 LRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGN 346
L++L L +GLT AL L+TN LTHL L GN
Sbjct: 829 LKKLWLVNSGLTSVCCSALSSVLSTN----QNLTHLYLRGN 865
Score = 37.4 bits (85), Expect = 0.10
Identities = 34/95 (35%), Positives = 44/95 (46%), Gaps = 8/95 (8%)
Query: 257 LRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGALRRLSLAQTGL 316
L F R L L+ +S L EL L+ N L D GM L L+ +RRL L + GL
Sbjct: 725 LTSSFCRGLFSVLS--TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGL 782
Query: 317 TPRGMRALGRALATNAAFDSTLTHLDLSGNPGALG 351
+ + L++N L LDLS N ALG
Sbjct: 783 SHECCFDISLVLSSN----QKLVELDLSDN--ALG 811
Score = 33.9 bits (76), Expect = 1.2
Identities = 32/119 (26%), Positives = 52/119 (43%), Gaps = 4/119 (3%)
Query: 452 AALQLFLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQV 511
+AL LS + L HL L G L ++ L +GL L+ + L+L C L S
Sbjct: 845 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGL-LHPDCKLQVLELDNCNLTSHCCWD 903
Query: 512 IQDLVCDAGAVSSLDLADNGFGSDMVTLVLAIGRSRSLRHVALGRN---FNVRCKETLD 567
+ L+ + ++ L L +N G V + + + +S LG + FN K L+
Sbjct: 904 LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALE 962
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 1124
Score = 54.7 bits (130), Expect = 6e-07
Identities = 101/378 (26%), Positives = 137/378 (36%), Gaps = 49/378 (12%)
Query: 1081 PATEGGATPVPRTLRKKLGTLFAF-KKPRSTRGPRTDLETSPGAAPRTRKT-TFGDLLR- 1137
P + PV + LG A +KP + R T P +APR T + G R
Sbjct: 30 PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRN 89
Query: 1138 PPTRP---SRGEELGGAE----GDTSSPDPA-GRSRPRYTRDSKAYSMILLPAEEEATLG 1189
P +RP RGE A+ G SSP A G +RP + + AEE G
Sbjct: 90 PASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRP----GPLGQKGLRISAEETVARG 145
Query: 1190 ARPD--KRRPLERGETE--LAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAG 1245
+ KR L G P+ M +R SR +G G + + +
Sbjct: 146 KATEAPKRSALSAGARRDTSGPTPGTPSPAMARR---SRAAGTEVGLPRPAPSARPRPP- 201
Query: 1246 SDGDIMDSSTEAPPISIKSRTHSVSADPSC----RP--GPGSQGPESATWKTLGQQLNAE 1299
TE P S+ S + + +PS RP G G Q P S + + L++
Sbjct: 202 ---------TEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 252
Query: 1300 LRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPED---PCLGPRNEDGQLRPRPLSA 1356
RS + P P Q + P + P P LGP + P P
Sbjct: 253 ARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGT 312
Query: 1357 GRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTEPSS 1416
R V ++ A P L SP L P APPSPS L T P PP +
Sbjct: 313 KARPVPPPDN---AATPLPATLPPSPPLAT-PLPLAPPSPSAPPSLQTLPSPP----ATP 364
Query: 1417 PERSPPSPATDQRGGGPN 1434
P ++PPS T P+
Sbjct: 365 PSQAPPSMTTPPMQAPPS 382
Score = 47.0 bits (110), Expect = 1e-04
Identities = 128/511 (25%), Positives = 164/511 (32%), Gaps = 80/511 (15%)
Query: 965 EEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAG-------------PLPRMDLPL 1011
++A+ P A P GSP P P PA PL +
Sbjct: 6 DKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGI 65
Query: 1012 AGQ------PLRHPTRARPRPRRQHHHRPPPGG--PQVPPALPQEGNGLSARVDEGVEEF 1063
G P PTR+ R RPP G + PPA +S+
Sbjct: 66 GGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSS--PGRASGT 123
Query: 1064 FSKRLIQQDRLWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGA 1123
+ Q L E+ G AT P+ G R T GP T SP
Sbjct: 124 TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGAR------RDTSGP-TPGTPSPAM 176
Query: 1124 APRTRKTTFGDLL---------RPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKA 1174
A R+R L RPPT R +E T+ P PA R RP A
Sbjct: 177 ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRP------SA 230
Query: 1175 YSMILLPA----EEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAE 1230
+ PA AT + P + P RG T AP+ + + G +
Sbjct: 231 GGGLQRPASRSLSSSATPLSSPARSGPSARG-TPRAPAHPSQPK-----------PKGLQ 278
Query: 1231 GKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSV-SADPSCRPGPGSQGPESATW 1289
R K A + SS A P ++ V D + P P + P
Sbjct: 279 ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLA 338
Query: 1290 KTLGQQLNAELRSRGWGQQDGPGPPS--PGQSPSPCRTSP--SPDSL-GLPEDPCLGPRN 1344
L L S Q P PP+ P Q+P T P +P SL +P P P +
Sbjct: 339 TPL--PLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIP--PIQVPHS 394
Query: 1345 EDG---QLRPRP--LSAGRRAVSVHEDQLQAP----AERPLRLQRSPVLKRRPKLEAPPS 1395
Q P P LS+ + S+ LQA P + Q S RP P S
Sbjct: 395 LTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDS 454
Query: 1396 PSLGSGLGTEPLPPQPTEPSSPERSPPSPAT 1426
P L + L PP T S SP T
Sbjct: 455 PPLQAPLSLPASPPLQTSLSPAVSPLSSPLT 485
Score = 47.0 bits (110), Expect = 1e-04
Identities = 128/530 (24%), Positives = 174/530 (32%), Gaps = 107/530 (20%)
Query: 935 EEKEKDDSPP-QKWPELSHGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARGSP- 992
E + SP ++ P GL P S + A P L++P ++GPSARG+P
Sbjct: 214 EHSTTEPSPAARRRPSAGGGLQR-PASRSLSSSATP---LSSPA-----RSGPSARGTPR 264
Query: 993 SPAAPG-----------PPAGPLPRMDL-----PLAGQPLRHP----TRARPRPRRQHHH 1032
+PA P PP PR D PL+ PL P T+ARP P +
Sbjct: 265 APAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAA 324
Query: 1033 RP-----PPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDPATEGGA 1087
P PP P P LP SA S + + P + P +
Sbjct: 325 TPLPATLPPSPPLATP-LPLAPPSPSAPP--------SLQTLPSPPATPPSQAPPS---M 372
Query: 1088 TPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEE 1147
T P L T+ + P S P SP A + TT L PT +
Sbjct: 373 TTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTS---LGSPTLQATHSF 429
Query: 1148 LGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAP 1207
L + T + SRP T P + +L A P PL+ T L+P
Sbjct: 430 LTMSPRQTQA-SLTSPSRPASTPPDSP------PLQAPLSLPASP----PLQ---TSLSP 475
Query: 1208 SFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTH 1267
+ + + S + + + + + S + PP S+ T
Sbjct: 476 AVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLT--TP 533
Query: 1268 SVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSP 1327
+ PS P P T L PP P +P P + P
Sbjct: 534 PLENLPSLAPPPLQTASAPLTTPHLET------------------PPCP--APCPLQAPP 573
Query: 1328 SPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRL--QRSPVLK 1385
SP + PE P + P A S L +P PL ++P
Sbjct: 574 SPLTTPPPETP--------SSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXL 625
Query: 1386 RRPKLEAPPSPSLGSGLG--TEPLPPQPT--------EPSSPERSPPSPA 1425
P L+APPSP L P P P P SP SPP A
Sbjct: 626 ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA 675
Score = 42.0 bits (97), Expect = 0.004
Identities = 105/481 (21%), Positives = 148/481 (30%), Gaps = 78/481 (16%)
Query: 969 PEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPL----PRMDLPLAGQPLRHPTRARP 1024
P PE + PQA P+ P P PP PL P+ LA PL+ P P
Sbjct: 579 PPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAP----P 634
Query: 1025 RPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDPATE 1084
P PP P P+ PQ N L+ + + F ++P P
Sbjct: 635 SPPAS-----PPLSPLATPS-PQAPNALAVHLLQA--PFSPPPSPPVQAPFSPPASPPVS 686
Query: 1085 GGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSR 1144
ATP + P S P + SP A+P + PP P
Sbjct: 687 PSATPPSQA-------------PPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP--PLA 731
Query: 1145 GEELGGAEGDTSSP--DPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLERGE 1202
L +SP P+ PR A + +P A+L P + P +
Sbjct: 732 APPLQVPPSPPASPPMSPSATPPPR-VPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPP 790
Query: 1203 TELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISI 1262
P + + G+ S + + + +APP+ +
Sbjct: 791 ALATPPLQ----------ALPSPPASFPGQAPFSPSASLPMS----PLATPPPQAPPV-L 835
Query: 1263 KSRTHSVSADPSCRP------GPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSP 1316
+ V P P P + GP+++ G +L L PGPP P
Sbjct: 836 AAPLLQVPPSPPASPTLQAPRRPPTPGPDTS---VSGPRLTLAL---------APGPPPP 883
Query: 1317 GQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPL 1376
S SP T PD G P +LR A + + A P
Sbjct: 884 -PSRSPSSTLSGPDLAGHSSSATSTPE----ELRGYDSGPEGGAAASPPPDAELAACHPA 938
Query: 1377 RLQRSP----VLKRRPKLEAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPSPATDQRGGG 1432
R P + P P P+ G G TE PE + P+P G
Sbjct: 939 AWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETE--GPESATPAPGALDPGPS 996
Query: 1433 P 1433
P
Sbjct: 997 P 997
Score = 40.8 bits (94), Expect = 0.009
Identities = 33/97 (34%), Positives = 38/97 (39%), Gaps = 15/97 (15%)
Query: 958 PFIHSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLR 1017
P SA ++ P LAAP P P A SP+A PP P P LA PL+
Sbjct: 684 PVSPSATPPSQAPPSLAAPPLQVPPS--PPASPPMSPSATPPPQAPPP-----LAAPPLQ 736
Query: 1018 HPTRARPRPRRQHHHRPPPGGP--------QVPPALP 1046
P P PPP P QVPP+ P
Sbjct: 737 VPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPP 773
Score = 38.1 bits (87), Expect = 0.061
Identities = 92/380 (24%), Positives = 115/380 (30%), Gaps = 77/380 (20%)
Query: 904 MPPALPAPDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFIHSA 963
+PP+ PA PS P + + SPP P + + P + +
Sbjct: 706 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMS-PSATPPPRVPPLLAAP 764
Query: 964 AEEAEPEPELAAPGEDAE---PQAGPSARGSPSPAAPGPPAG------------------ 1002
+ P P + P PQA P+ P A P PPA
Sbjct: 765 PLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL 824
Query: 1003 --PLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGV 1060
P P+ LA L+ P P Q RPP GP + P+ L+
Sbjct: 825 ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPP 884
Query: 1061 EEFFSKRLIQQD-------RLWAPEE----DPATEGGATPVPRTLRKKLGTLFAFKKPRS 1109
S L D PEE D EGGA P L A
Sbjct: 885 SRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASP----PPDAELAACHPAAW 940
Query: 1110 TRGPRTDL--ETSPGAAPRTRKTTFGDLLRPP-TRPSRGE------ELGGAEGDTSSPDP 1160
+RGP L +PGA L PP T P + E G E T +P
Sbjct: 941 SRGPAPPLAFRGAPGA----------PLPWPPATGPGSADGLCTIYETEGPESATPAPGA 990
Query: 1161 AGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLER--GETELAPSFEQRVQVMLQ 1218
T KA A GA R P + GE L VQ +L
Sbjct: 991 LDPGPSPGTSGGKA----------AAGAGAGASSRSPKQARLGELPLGALQASVVQHLLS 1040
Query: 1219 RI-------GVSRGSGGAEG 1231
R G + GSGG G
Sbjct: 1041 RTLLLAAAEGAAGGSGGGPG 1060
Score = 37.0 bits (84), Expect = 0.14
Identities = 39/141 (27%), Positives = 49/141 (34%), Gaps = 35/141 (24%)
Query: 1313 PPSPGQSPSPCRTSPSPDSLGLPE---------DPCLGPRNEDGQLRPRPLSAGRRAVSV 1363
P SP SPS S +P SL P P + P P PL+A
Sbjct: 680 PASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAA------- 732
Query: 1364 HEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTEPSS------- 1416
LQ P P SP A P P + L PL P+ P+S
Sbjct: 733 --PPLQVPPSPPASPPMSP--------SATPPPRVPPLLAAPPLQVPPSPPASLPMSPLA 782
Query: 1417 --PERSPPSPATDQRGGGPNP 1435
P ++PP+ AT P+P
Sbjct: 783 KPPPQAPPALATPPLQALPSP 803
Score = 36.6 bits (83), Expect = 0.18
Identities = 127/565 (22%), Positives = 182/565 (32%), Gaps = 92/565 (16%)
Query: 913 GGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFIHSAAEEAEPEPE 972
G +P G + G PE S P+ P S G +++ P
Sbjct: 54 GRKPLAERAGGIGGATIPE----------SAPRAGPTRSAG--------TSSRNPASRPP 95
Query: 973 LAAPGEDAEP--QAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRR-- 1028
+ GE A P P SP A+ GPL + L ++ + +A P+R
Sbjct: 96 ASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSA 155
Query: 1029 ------QHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDP- 1081
+ P PG P PA+ + V R R P E P
Sbjct: 156 LSAGARRDTSGPTPGTPS--PAMARRSRAAGTEVG-------LPRPAPSARPRPPTEGPR 206
Query: 1082 -----ATEGGATPVPRTLRKKLGTLFAFKKP--RSTRGPRTDLETSPGAAPRTRKTTFG- 1133
A+E T R++ ++P RS T L + + P R T
Sbjct: 207 KSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAP 266
Query: 1134 -----------DLLRPPTRPSRGEELGGAEGDTSS-----PDPAG-RSRPRYTRDSKAYS 1176
LRPP ++ A G SS P P+G ++RP D+ A
Sbjct: 267 AHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATP 326
Query: 1177 MILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGV--SRGSGGAEGKRK 1234
+ ATL P PL +PS +Q + S+
Sbjct: 327 L-------PATLPPSPPLATPLPLAPP--SPSAPPSLQTLPSPPATPPSQAPPSMTTPPM 377
Query: 1235 QSKDG--EIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWKTL 1292
Q+ I + S +APP + S+ A S P Q S +
Sbjct: 378 QAPPSLQTIPPIQVPHSLTSPSLQAPPSPLA--LSSLQATTSLG-SPTLQATHSFLTMS- 433
Query: 1293 GQQLNAELRSRGWGQQDGPGPPSPGQSP------SPCRTSPSPDSLGLPEDPCLGPRNED 1346
+Q A L S P P P Q+P P +TS SP L + P
Sbjct: 434 PRQTQASLTSPSRPASTPPDSP-PLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQAL 492
Query: 1347 GQLRPR----PLSAGRRAVSVHEDQLQAPA-ERPLRLQRSPVLKRRPKLEAPPSPSLGSG 1401
L PLS+ + L P+ + P +P L+ P L PP + +
Sbjct: 493 SSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAP 552
Query: 1402 LGTEPLPPQPTEPSSPERSPPSPAT 1426
L T L P P ++PPSP T
Sbjct: 553 LTTPHLETPPCPAPCPLQAPPSPLT 577
Score = 32.3 bits (72), Expect = 3.4
Identities = 25/72 (34%), Positives = 33/72 (45%), Gaps = 8/72 (11%)
Query: 1371 PAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPLP---PQPTEPSS----PERSPPS 1423
P+ P LQ + P LE PP P+ L P P P P PSS P ++PP+
Sbjct: 539 PSLAPPPLQTASAPLTTPHLETPPCPA-PCPLQAPPSPLTTPPPETPSSIATPPPQAPPA 597
Query: 1424 PATDQRGGGPNP 1435
A+ G P+P
Sbjct: 598 LASPPLQGLPSP 609
>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
Length = 2157
Score = 54.7 bits (130), Expect = 6e-07
Identities = 122/544 (22%), Positives = 187/544 (34%), Gaps = 115/544 (21%)
Query: 964 AEEAEPEPELAAPGED----AEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHP 1019
AE +P ++ +D A Q + S + A P + PLP P + QP R
Sbjct: 67 AENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPKR-- 124
Query: 1020 TRARPRPRRQHHHRPPPGGPQVPPALPQ----------------EGNGLSARVDEGVEEF 1063
PP P+ P +P +G S+ + E
Sbjct: 125 ---------------PPAAPENTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREE 169
Query: 1064 FSKRLIQQDRLWAPEEDPATEGGATPVPRTLRKKLGTLF---AFKKPRSTRGPRTDLETS 1120
F D+ A +E + E + P P +LR + T + + P GP D +
Sbjct: 170 FPTLQAAGDQDKAAKERESAEQSSGPGP-SLRPQNSTTWRDGGGRGPDELEGP--DSKLH 226
Query: 1121 PGAAPRTRKTTFGDLLRPPTRPSRGEEL----------GGAEGDTSSPDPAGRSR-PRYT 1169
G PR G PP R + G +G P P G SR PR
Sbjct: 227 HGHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVA 286
Query: 1170 --RDSKAYSMILLPAEEEATLGARPDKRRPLERGETE---------LAPSFEQRVQVMLQ 1218
R S ++ P + L + D + ++ + E + ++++ +
Sbjct: 287 GPRGSGPPMRLVEPVGRPSIL--KEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDE 344
Query: 1219 RIGVSRGSGGAEGKR-KQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRP 1277
G GAEG R QS GE + +DG +S PP + K+ S P P
Sbjct: 345 EDGRDSDEEGAEGHRDSQSASGEERPPEADGKKGNSPNSEPP-TPKTAWAETSRPPETEP 403
Query: 1278 GPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPED 1337
GP + P RG GP P + PC+ P+P+ ED
Sbjct: 404 GPPAPKPPLPP------------PHRGPAGNWGPPGDYPDRGGPPCK-PPAPED----ED 446
Query: 1338 PCLGPRNEDG---------QLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQR---SPVLK 1385
R + + R R RR + E++ A AE+ RL +P +
Sbjct: 447 EAWRQRRKQSSSEISLAVERARRRREEEERR---MQEERRAACAEKLKRLDEKFGAPDKR 503
Query: 1386 RRPKLEAPPS--------PSLGSGLGTEPLPP------QPTEPSSPERSPPSPATDQRGG 1431
+ + APP+ P++ L P PP TEP P ++PP+ +T G
Sbjct: 504 LKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGV 563
Query: 1432 GPNP 1435
P
Sbjct: 564 AAAP 567
Score = 52.0 bits (123), Expect = 4e-06
Identities = 138/563 (24%), Positives = 187/563 (33%), Gaps = 110/563 (19%)
Query: 902 VTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFIH 961
V PP A G P PG P E+ P WP P
Sbjct: 828 VPPPPPYLASYPGFPENGAPG-------PPISRFPLEEPGPRPLPWP---------PGSD 871
Query: 962 SAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTR 1021
A+ P P+ P E+ GP A P+ GP P + R TR
Sbjct: 872 EVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQGP------PPPRRESRTETR 925
Query: 1022 ARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDP 1081
PRP PP P PP + G VEE K L Q D P
Sbjct: 926 WGPRPGSSRRGIPPE-EPGAPPR--RAGPIKKPPPPTKVEELPPKPLEQGDETPKP---- 978
Query: 1082 ATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGA----APRTRKTTFGDLLR 1137
P P L+ G L GP+ ET P APR R+ + +
Sbjct: 979 -------PKPDPLKITKGKL---------GGPK---ETPPNGNLSPAPRLRRDYSYERVG 1019
Query: 1138 PPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRP 1197
P + RG A G GR R +R+ ++Y ++ G P
Sbjct: 1020 PTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYRE--FRGDDGRGGGTGGPNHPP 1077
Query: 1198 LERGETELAPSFEQRVQVMLQRIGVSRGSGGAE-GKRKQSKDGEIKKAGSDGDIMDSSTE 1256
RG T + E R S GS E KR++ + E + D+ S E
Sbjct: 1078 APRGRT----ASETR----------SEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKE 1123
Query: 1257 APPISIKSRTHSVSADPSCRPGPGS-QGPESATWKTLGQQLNA-----ELRSRGWGQ--- 1307
AP + +++ P P PG+ P A + G ++ R RG G+
Sbjct: 1124 AP----TPKEGTLTQVPLAPPPPGAPPSPAPARFTARGGRVFTPRGVPSRRGRGGGRPPP 1179
Query: 1308 QDGPG--PPSPGQSPSPCRTSPSPDSL-GLPEDPCLGPRN---------------EDGQL 1349
Q PG PP+ +P T P P S L E GP + EDG+
Sbjct: 1180 QVCPGWSPPAKSLAPKKPPTGPLPPSKEPLKEKLIPGPLSPVARGGSNGGSNVGMEDGE- 1238
Query: 1350 RPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLK---RRPKLEAPPS-PSLGSGLGTE 1405
RPR GR + Q + P R L+ +R + +P L P S P L T
Sbjct: 1239 RPRRRRHGRA-----QQQDKPPRFRRLKQERENAARGSEGKPSLTLPASAPGPEEALTTV 1293
Query: 1406 PLPPQPTEPSSPERSPPSPATDQ 1428
+ P P ++ + +DQ
Sbjct: 1294 TVAPAPRRAAAKSPDLSNQNSDQ 1316
Score = 46.2 bits (108), Expect = 2e-04
Identities = 146/671 (21%), Positives = 211/671 (31%), Gaps = 154/671 (22%)
Query: 876 SIVAQALAGLSAARDQLVESLAQQATVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEE 935
S+V + G ++ ++Q + +T P + P P P+ +P P E
Sbjct: 77 SLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPKR------PPAAPE 130
Query: 936 EKEKDDSPPQKWPELS--HGLH----------------LVPFIHSA------AEEAEPEP 971
S + W + S HG H P + +A A+E E
Sbjct: 131 NTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGDQDKAAKERESAE 190
Query: 972 ELAAPGEDAEPQAGPSAR---GSPSPAAPGPPA----GPLPRMDLPLAGQPLRHPTRARP 1024
+ + PG PQ + R G GP + G PR L +G P P R
Sbjct: 191 QSSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMM 250
Query: 1025 RPRRQHHHRP--PPGGPQVPPALPQ-------------EGNGLSARVDEGVEEFFSKRLI 1069
P + P PP GPQ P P G+G R+ VE ++
Sbjct: 251 PPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPPMRL---VEPVGRPSIL 307
Query: 1070 QQDRLWA-----PEEDPATEGGATPVPRTLRKKL---------------GTLFAFKKPRS 1109
++D L E D G V T + K G +
Sbjct: 308 KEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRDSQSASGE 367
Query: 1110 TRGPRTDLE--TSPGAAPRTRKTTFGDLLRPPTR-------------PSRGEELG-GAEG 1153
R P D + SP + P T KT + + RPP P RG G G
Sbjct: 368 ERPPEADGKKGNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPAGNWGPPG 427
Query: 1154 DTSSPDPAGR--SRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQ 1211
D PD G P + +A+ + E +L +RR E E E+
Sbjct: 428 DY--PDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRR----EEEERRMQEE 481
Query: 1212 RVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSA 1271
R +++ GA KR +++ A ST APP ++ + A
Sbjct: 482 RRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAA--------PSTPAPPPAVPKELPAPPA 533
Query: 1272 DPSC-------RPGPGSQGPESATWKTLGQQLNAELRSRGWG------------------ 1306
P P +Q P + + T G L S G
Sbjct: 534 PPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQL 593
Query: 1307 -QQDGPGPPS---PGQSPSPCRTSPSPDSLGLPEDPC---LGPRNEDGQLRPRPLSAGRR 1359
++GP PP P +P + P D +G P LG L PR +
Sbjct: 594 PSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQE 653
Query: 1360 AVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPL------PPQPTE 1413
+ + Q Q + +PV PPSP LG P PP+
Sbjct: 654 QLLKQQQQHQWQQHQQGSAPPTPV---------PPSPPQPVTLGAVPAPQAPPPPPKALY 704
Query: 1414 PSSPERSPPSP 1424
P + R PP P
Sbjct: 705 PGALGRPPPMP 715
Score = 42.0 bits (97), Expect = 0.004
Identities = 126/556 (22%), Positives = 176/556 (31%), Gaps = 122/556 (21%)
Query: 914 GEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQ---KWPELSHGLHLVPFIHSAAEEAEPE 970
G+PSL P G PEE +P + K P+LS+ +++A E
Sbjct: 1273 GKPSLTLPASAPG---PEEALTTVTVAPAPRRAAAKSPDLSN---------QNSDQANEE 1320
Query: 971 PELAAPGEDAEPQAGPSARGSP----SPAAPGPPAG----------PLPRMDLPLAGQPL 1016
E A+ D + P +P A G P G + R DL + L
Sbjct: 1321 WETASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSRGDLSQRAKDL 1380
Query: 1017 RHPTRARPRP-RRQHHHRPPPGGPQVPPALPQEGNG--LSARVDEGVEEFFSKRLIQQDR 1073
+ + RP + + RP PGG G G R G + S ++R
Sbjct: 1381 SKRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPS-PKNR 1439
Query: 1074 LWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLE------TSPGAAPRT 1127
PEE P P P + P + L T+PG PR
Sbjct: 1440 SRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRH 1499
Query: 1128 R----KTTFGDLLRPPTR--PSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLP 1181
+ + G RPPTR P R ++ P P R RDS S
Sbjct: 1500 KPGLPQAPQGPSPRPPTRYEPQRVNSGLSSDPHFEEPGPMVRGVGGTPRDSAGVSPFPPK 1559
Query: 1182 AEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEI 1241
E RP ++ L + E+ P S G G + +
Sbjct: 1560 RRE------RPPRKPELLQEESLPPPH-----------------SSGFLGSKPEGP---- 1592
Query: 1242 KKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELR 1301
G + D+ TEA I +R H+ ++ S R P S P E+
Sbjct: 1593 ---GPQAESRDTGTEALTPHIWNRLHTATSRKSYR--PSSMEPWMEPLSPFEDVAGTEMS 1647
Query: 1302 SRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPED--------------PCLGPRNEDG 1347
G D G P R+SP G E PC GP +
Sbjct: 1648 QSDSG-VDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPGGSSPLNAVPCEGPPGSEP 1706
Query: 1348 QLRPRPLSAGRRAVSVHE-DQLQAPAERPLRLQRSPVLKRRPKLEAPPSP-----SLGSG 1401
RP P + H+ D+ + P E+PL PP P S +
Sbjct: 1707 PRRPPP--------APHDGDRKELPREQPL----------------PPGPIGTERSQRTD 1742
Query: 1402 LGTEPLPPQPTEPSSP 1417
GTEP P +P+ P
Sbjct: 1743 RGTEPGPIRPSHRPGP 1758
Score = 40.8 bits (94), Expect = 0.009
Identities = 113/500 (22%), Positives = 162/500 (32%), Gaps = 97/500 (19%)
Query: 966 EAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPR 1025
+AEP AAP A P A P + P+P AP P + P P + P +A P
Sbjct: 505 KAEPAAPPAAPSTPAPPPAVP--KELPAPPAPPPASAPTPETEP-------EEPAQAPPA 555
Query: 1026 PRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEF--FSKRLIQQDRLWAPEEDPAT 1083
P PG P + G G ++ G E +L ++ PEE P
Sbjct: 556 -----QSTPTPGVAAAPTLV--SGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPP 608
Query: 1084 EGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLR------ 1137
PVP+ K G + P G ++ P PR ++ LL+
Sbjct: 609 T--TPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLP---PRFQRQQQEQLLKQQQQHQ 663
Query: 1138 ---------PPT----RPSRGEELGGAEGDTSSPDPA--------GRSRPRYTRDSKAYS 1176
PPT P + LG + P P GR P +
Sbjct: 664 WQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRW 723
Query: 1177 MILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQS 1236
M++ P + L RP PL+ + PS R++S
Sbjct: 724 MMIPPYVDPRLLQGRP----PLDFYPPGVHPS--------------------GLVPRERS 759
Query: 1237 KDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQL 1296
G GS + D P ++ R P P G + L
Sbjct: 760 DSG-----GSSSEPFDRHA---PAMLRER-----GTPPVDPKLAWVGDVFTATPAEPRPL 806
Query: 1297 NAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLR---PRP 1353
+ LR G +P P P + P G PE+ GP L PRP
Sbjct: 807 TSPLRQAADEDDKGMRSETPPVPPPPPYLASYP---GFPENGAPGPPISRFPLEEPGPRP 863
Query: 1354 LSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTE 1413
L + V + Q P + P + + + + EA P+ G G G + PP E
Sbjct: 864 LPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGP----EAGRKPARGVGSGGQGPPPPRRE 919
Query: 1414 PSSPERSPPSPATDQRGGGP 1433
+ R P P + +RG P
Sbjct: 920 SRTETRWGPRPGSSRRGIPP 939
Score = 39.3 bits (90), Expect = 0.028
Identities = 129/542 (23%), Positives = 176/542 (32%), Gaps = 95/542 (17%)
Query: 898 QQATVTMPPALPAPDGGEPSLLEPGELEG----LFFPEEKEEEKEKDDS--PPQKWPELS 951
++ T+T P P P G PS P +F P + + PPQ P S
Sbjct: 1128 KEGTLTQVPLAPPPPGAPPS-PAPARFTARGGRVFTPRGVPSRRGRGGGRPPPQVCPGWS 1186
Query: 952 HGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPL 1011
P S A + P L E + + P G SP A G G
Sbjct: 1187 ------PPAKSLAPKKPPTGPLPPSKEPLKEKLIP---GPLSPVARGGSNG--------- 1228
Query: 1012 AGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQ 1071
G + RPR RR+H P L QE +AR EG +
Sbjct: 1229 -GSNVGMEDGERPR-RRRHGRAQQQDKPPRFRRLKQEREN-AARGSEG-----------K 1274
Query: 1072 DRLWAPEEDPATEGGAT-----PVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPR 1126
L P P E T P PR K L ++ T E+S + R
Sbjct: 1275 PSLTLPASAPGPEEALTTVTVAPAPRRAAAKSPDLSNQNSDQANEEWETASESSDFTSER 1334
Query: 1127 TRKTTFGDLLRPPTRPSRGEELG--GAEGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEE 1184
GD PP + +G G G + P + SR ++ +K S ++
Sbjct: 1335 R-----GDKEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSRGDLSQRAKDLSKRSFSSQR 1389
Query: 1185 EATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKA 1244
G RRP G+ + S S G GG G R G+ +
Sbjct: 1390 P---GMERQNRRPGPGGKAGSSGS-------------SSGGGGGGPGGRTGPGRGDKRSW 1433
Query: 1245 GSDGDIMDSSTEAPP-ISIKSRTHSVSA----DPSCRPGPGSQGPESATWKTLGQQLNAE 1299
S + E PP + + S SA D P G + A + +Q
Sbjct: 1434 PSPKNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPA--GIQQALAQLSSRQ--GS 1489
Query: 1300 LRSRGWGQQDGPGPPSPGQSPS---PCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSA 1356
+ + G + PG P Q PS P R P + GL DP P P+
Sbjct: 1490 VTAPGGHPRHKPGLPQAPQGPSPRPPTRYEPQRVNSGLSSDPHFE--------EPGPMVR 1541
Query: 1357 GRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKL---EAPPSPSLGSGLGTEPLPPQPTE 1413
G D P R +R P R+P+L E+ P P LG++P P P
Sbjct: 1542 G--VGGTPRDSAGVSPFPPKRRERPP---RKPELLQEESLPPPHSSGFLGSKPEGPGPQA 1596
Query: 1414 PS 1415
S
Sbjct: 1597 ES 1598
Score = 35.8 bits (81), Expect = 0.30
Identities = 120/502 (23%), Positives = 159/502 (31%), Gaps = 136/502 (27%)
Query: 956 LVPFIHSAAEEAEPEPELAAPGEDAEPQAGP-SARGSPSP----AAPGPP---AGPLPRM 1007
L PF A E D++ +GP S R SP AA GPP G P
Sbjct: 1635 LSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPGGSSPLN 1694
Query: 1008 DLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKR 1067
+P G P P R RPPP P +G
Sbjct: 1695 AVPCEGPPGSEPPR-----------RPPPA--------PHDG------------------ 1717
Query: 1068 LIQQDRLWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRT 1127
DR P E P G +GT R RTD T PG
Sbjct: 1718 ----DRKELPREQPLPPG-----------PIGT---------ERSQRTDRGTEPGP---- 1749
Query: 1128 RKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEAT 1187
+RP RP + G ++ D+ G S L AE+E T
Sbjct: 1750 --------IRPSHRPGPPVQFGTSDKDSDLRLVVGDS---------------LKAEKELT 1786
Query: 1188 LGARPDKRRPLERGETELAPSFEQRVQVMLQRIG----VSRGSGGAEGKRKQSKDGEIKK 1243
A + P+ R + EL PS + + + V S + + G
Sbjct: 1787 --ASVTEAIPVSR-DWELLPSAAASAEPQSKNLDSGHCVPEPSSSGQRLYPEVFYGSAGP 1843
Query: 1244 AGS--DGDIMDSSTEAPPISIKSRTHSV----SADPSCRPGPGSQGPESATWKTLGQQLN 1297
+ S G MDS + T S+ S PGP + GQ L+
Sbjct: 1844 SSSQISGGAMDSQLHPNSGGFRPGTPSLHPYRSQPLYLPPGPAPPSALLSGLALKGQFLD 1903
Query: 1298 -AELRSRGWGQQDGPG----PPSPGQSPSPCRTSPSPDS--------LGLPEDPCLGPRN 1344
+ +++ G+ G PPS SP+ C SP PD+ L P D P
Sbjct: 1904 FSTMQATELGKLPAGGVLYPPPSFLYSPAFC-PSPLPDTSLLQVRQDLPSPSDFYSTPLQ 1962
Query: 1345 EDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGT 1404
GQ P A + + + Q P L +P PP+P L
Sbjct: 1963 PGGQSGFLPSGAPAQQMLLPMVDSQLPVVNFGSLPPAP----------PPAP---PPLSL 2009
Query: 1405 EPLPPQPTEPSSPERSPPSPAT 1426
P+ P PS R PP+PAT
Sbjct: 2010 LPVGPALQPPSLAVRPPPAPAT 2031
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 54.7 bits (130), Expect = 6e-07
Identities = 60/213 (28%), Positives = 90/213 (42%), Gaps = 43/213 (20%)
Query: 467 LGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGAVSSLD 526
LG G KL LR L N L+ + SACE SA ++L + +D
Sbjct: 725 LGSRGVKLLCQGLRHPNCKLQ-NLRLKRCRISSSACEDLSAALIANKNL-------TRMD 776
Query: 527 LADNGFGSDMVTLVLAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDCPLQS 586
L+ NG G + L+ LRH C LQ
Sbjct: 777 LSGNGVGFPGMMLLC-----EGLRH----------------------------PQCRLQM 803
Query: 587 LSVAESRLKLGA-SVLLRALATNPNLTALDISGNAMGDAGAKLLAKALR-VNSRLRSVVW 644
+ + + +L+ GA + L TNP+L LD++GNA+ D G +LL + LR RLR++
Sbjct: 804 IQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWL 863
Query: 645 DRNHTSALGLLDVAQALEQNHSLKAMPLPLNDV 677
+A ++A L N SL+ + L LN++
Sbjct: 864 KICRLTAAACDELASTLSVNQSLRELDLSLNEL 896
Score = 51.6 bits (122), Expect = 5e-06
Identities = 103/391 (26%), Positives = 146/391 (37%), Gaps = 65/391 (16%)
Query: 261 FVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGALRRLSLAQTGLTPRG 320
+ LA AL ++ L ELSL N L RG+ L + L L+ L L + ++
Sbjct: 701 YSEHLAAALC--TNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSA 758
Query: 321 MRALGRALATNAAFDSTLTHLDLSGN----PGALGASEDSGGLYSFLSRPNVLSFLNLAG 376
L AL N LT +DLSGN PG + E GL R ++
Sbjct: 759 CEDLSAALIAN----KNLTRMDLSGNGVGFPGMMLLCE---GLRHPQCRLQMIQ------ 805
Query: 377 TDTALDTVRGCSVGGWMTGRADWRAGRGGLGPPAGVANSLPPQLFAAVSRGCCTSLTHLD 436
+R C + G A V + P L LD
Sbjct: 806 -------LRKCQLES------------GACQEMASVLGTNP-------------HLVELD 833
Query: 437 ASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLH 496
+ N R L+ + R RTL L C+L A L L++N LR+L
Sbjct: 834 LTGNALEDLGLRLLCQGLRHPVCRLRTL---WLKICRLTAAACDELASTLSVNQSLREL- 889
Query: 497 LDLSACELRSAGAQVI-QDLVCDAGAVSSLDLADNGFGSDMVT-LVLAIGRSRSLRHVAL 554
DLS EL G ++ + L + +L L GS L + + + +LR + L
Sbjct: 890 -DLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDL 948
Query: 555 GRNFNVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRLKLGASV-LLRALATNPNLTA 613
N + D L + + +Q C LQ L + L A L L N LT
Sbjct: 949 SFN------DLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTD 1002
Query: 614 LDISGNAMGDAGAKLLAKALRVNSRLRSVVW 644
L ++ NA+GD G +LL K L V+W
Sbjct: 1003 LYLTNNALGDTGVRLLCKRLSHPGCKLRVLW 1033
Score = 46.6 bits (109), Expect = 2e-04
Identities = 31/78 (39%), Positives = 42/78 (53%), Gaps = 1/78 (1%)
Query: 601 LLRALATNPNLTALDISGNAMGDAGAKLLAKALR-VNSRLRSVVWDRNHTSALGLLDVAQ 659
L AL TNPNL L + NA+G G KLL + LR N +L+++ R S+ D++
Sbjct: 705 LAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSA 764
Query: 660 ALEQNHSLKAMPLPLNDV 677
AL N +L M L N V
Sbjct: 765 ALIANKNLTRMDLSGNGV 782
Score = 37.0 bits (84), Expect = 0.14
Identities = 35/106 (33%), Positives = 46/106 (43%), Gaps = 7/106 (6%)
Query: 247 LEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGAL 306
L+ + L C L + +A L ++ L EL L GN L+D G+ L + L L
Sbjct: 801 LQMIQLRKCQLESGACQEMASVLG--TNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRL 858
Query: 307 RRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNP-GALG 351
R L L LT L L+ N +L LDLS N G LG
Sbjct: 859 RTLWLKICRLTAAACDELASTLSVN----QSLRELDLSLNELGDLG 900
Score = 35.0 bits (79), Expect = 0.52
Identities = 36/105 (34%), Positives = 48/105 (45%), Gaps = 8/105 (7%)
Query: 247 LEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGAL 306
L+ L L C L L+ L ++ LREL L+ N L D G+ L+ L+ L
Sbjct: 915 LQTLRLGICRLGSAACEGLSVVL--QANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRL 972
Query: 307 RRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNPGALG 351
++L L GLT + L L N TLT L L+ N ALG
Sbjct: 973 QKLWLDSCGLTAKACENLYFTLGIN----QTLTDLYLTNN--ALG 1011
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 53.9 bits (128), Expect = 1e-06
Identities = 65/259 (25%), Positives = 112/259 (43%), Gaps = 33/259 (12%)
Query: 465 RHLGLAGCKLPPDALRALLDGLA---------------LNTHLRDLHLDLSACELRSAGA 509
RHL + C LP + A GL L+++ + + LDLS L G
Sbjct: 699 RHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGI 758
Query: 510 QVI----QDLVCDAGAVSSLDLADNGFGSDMVTLVLAIGRSRSLRHVALGRNFNVRCKET 565
+++ + L+C+ + + + VL+ S SL + +G N
Sbjct: 759 RLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLST--SHSLTRLYVGEN------AL 810
Query: 566 LDDVLHRIVQLMQDDDCPLQSLSVAESRL-KLGASVLLRALATNPNLTALDISGNAMGDA 624
D + + + ++ C LQ L + S L + S L L+TN NLT L + GN +GD
Sbjct: 811 GDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDK 870
Query: 625 GAKLLAKA-LRVNSRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLNDVAQAQRS 683
G KLL + L + +L+ + D + ++ D++ L + SL+ + L ND+
Sbjct: 871 GIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDL--- 927
Query: 684 RPELTARAVHQIQACLLRN 702
+ V + Q+CLL+N
Sbjct: 928 -GVMMFCEVLKQQSCLLQN 945
Score = 42.7 bits (99), Expect = 0.002
Identities = 34/101 (33%), Positives = 48/101 (47%), Gaps = 6/101 (5%)
Query: 246 HLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGA 305
+L++L L +C L + LA L+ +S L L + N L D G+ L +
Sbjct: 771 NLKKLWLVSCCLTSACCQDLASVLS--TSHSLTRLYVGENALGDSGVAILCEKAKNPQCN 828
Query: 306 LRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGN 346
L++L L +GLT AL L+TN LTHL L GN
Sbjct: 829 LQKLGLVNSGLTSVCCSALSSVLSTN----QNLTHLYLRGN 865
Score = 33.9 bits (76), Expect = 1.2
Identities = 32/119 (26%), Positives = 52/119 (43%), Gaps = 4/119 (3%)
Query: 452 AALQLFLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQV 511
+AL LS + L HL L G L ++ L +GL L+ + L+L C L S
Sbjct: 845 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGL-LHPDCKLQVLELDNCNLTSHCCWD 903
Query: 512 IQDLVCDAGAVSSLDLADNGFGSDMVTLVLAIGRSRSLRHVALGRN---FNVRCKETLD 567
+ L+ + ++ L L +N G V + + + +S LG + FN K L+
Sbjct: 904 LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALE 962
>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
sapiens]
Length = 287
Score = 53.9 bits (128), Expect = 1e-06
Identities = 34/103 (33%), Positives = 57/103 (55%), Gaps = 2/103 (1%)
Query: 577 MQDDDCPLQSLSVAESRLKLGA-SVLLRALATNPNLTALDISGNAMGDAGAKLLAKALR- 634
++ C LQ + + + +L+ GA + L TNP+L LD++GNA+ D G +LL + LR
Sbjct: 77 LRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRH 136
Query: 635 VNSRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLNDV 677
RLR++ +A ++A L N SL+ + L LN++
Sbjct: 137 PVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNEL 179
Score = 42.4 bits (98), Expect = 0.003
Identities = 60/220 (27%), Positives = 81/220 (36%), Gaps = 38/220 (17%)
Query: 429 CTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHL---GLAGCKLPPDALRALLDG 485
C L H + K + A Q S T HL L G L LR L G
Sbjct: 74 CEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQG 133
Query: 486 LALNT-HLRDLHLDLSACELRSAGAQVIQDLVCDAGAVSSLDLADNGFGSDMVTLVLAIG 544
L LR L L + C L +A + + ++ LDL+ N G D+ L+L G
Sbjct: 134 LRHPVCRLRTLWLKI--CRLTAAACDELASTLSVNQSLRELDLSLNELG-DLGVLLLCEG 190
Query: 545 RSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRLKLGASVLLRA 604
LRH CK +Q ++ D C L + + LG
Sbjct: 191 ----LRHPT--------CK----------LQTLRLDSCGLTAKACENLYFTLGI------ 222
Query: 605 LATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLRSVVW 644
N LT L ++ NA+GD G +LL K L V+W
Sbjct: 223 ---NQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLW 259
Score = 37.0 bits (84), Expect = 0.14
Identities = 35/106 (33%), Positives = 46/106 (43%), Gaps = 7/106 (6%)
Query: 247 LEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGAL 306
L+ + L C L + +A L ++ L EL L GN L+D G+ L + L L
Sbjct: 84 LQMIQLRKCQLESGACQEMASVLG--TNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRL 141
Query: 307 RRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNP-GALG 351
R L L LT L L+ N +L LDLS N G LG
Sbjct: 142 RTLWLKICRLTAAACDELASTLSVN----QSLRELDLSLNELGDLG 183
Score = 37.0 bits (84), Expect = 0.14
Identities = 38/105 (36%), Positives = 46/105 (43%), Gaps = 8/105 (7%)
Query: 247 LEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGAL 306
L L L+ C L LA L+ + S LREL L+ N L D G+ L L L
Sbjct: 141 LRTLWLKICRLTAAACDELASTLSVNQS--LRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
Query: 307 RRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNPGALG 351
+ L L GLT + L L N TLT L L+ N ALG
Sbjct: 199 QTLRLDSCGLTAKACENLYFTLGIN----QTLTDLYLTNN--ALG 237
Score = 35.0 bits (79), Expect = 0.52
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 601 LLRALATNPNLTALDISGNAMGDAGAKLLAKALR-VNSRLRSVVWDRNHTSALGLLDVAQ 659
L AL N NLT +D+SGN +G G LL + LR RL+ + + + ++A
Sbjct: 45 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 104
Query: 660 ALEQNHSLKAMPLPLN 675
L N L + L N
Sbjct: 105 VLGTNPHLVELDLTGN 120
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 53.5 bits (127), Expect = 1e-06
Identities = 61/250 (24%), Positives = 94/250 (37%), Gaps = 33/250 (13%)
Query: 931 EEKEEEKEKDDSPPQKWPELSHGLHLVPFIHSAAEEAE---PEPELAAPGEDAEPQAGPS 987
EE+++E+E+ D ++ E + ++P AAE+ E P P L P P P
Sbjct: 365 EEEKKEEEEKDKEGEEKEERAVAEEMMP----AAEKEEAKLPPPPLTPPAPSPPPPLPPP 420
Query: 988 ARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQV------ 1041
+ P P P PP P++ PL P+ P + + PPP P
Sbjct: 421 STSPPPPLCPPPPP--------PVSPPPL--PSPPPPPAQEEQEESPPPVVPATCSRKRG 470
Query: 1042 -PPALP-QEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEED-PATEGGATPVPRTLRKKL 1098
PP P Q +AR G E P ED P +T + +R+ +
Sbjct: 471 RPPLTPSQRAEREAARA--GPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFI 528
Query: 1099 GTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPP--TRPSRGEELGGAEGDTS 1156
+ + + R + PR ++ P P+ K +LRPP T P +E
Sbjct: 529 MPVVSARSSRVIKTPRRFMDEDP---PKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPR 585
Query: 1157 SPDPAGRSRP 1166
+P P P
Sbjct: 586 APTPPSTPVP 595
Score = 51.6 bits (122), Expect = 5e-06
Identities = 136/590 (23%), Positives = 205/590 (34%), Gaps = 82/590 (13%)
Query: 893 VESLAQQATVTMPPALPA-PDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELS 951
+E+ + T+ PA + P GGE L+ L P E + P P+
Sbjct: 1795 LEAAEENQTIVHSPAPSSEPPGGEDPPLDTDVL----VPGAPERHSPIQNLDPPLRPDSG 1850
Query: 952 HGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRM---D 1008
P S A P P G S PSP +P +P + D
Sbjct: 1851 SAPPPAPRSFSGARIKVPNYS-----PSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPD 1905
Query: 1009 LPLAGQPLRHPTRARPRPRRQHHHRPP-PGGPQ--VPPA-------------LPQEGNGL 1052
P + R P+ PRP PP PQ VPP L G
Sbjct: 1906 FPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAP 1965
Query: 1053 SARVDEGVEEFFSKRLIQQDRLWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRG 1112
S E + F + A + A+ G P ++++ A G
Sbjct: 1966 SPPPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEP----FQEEIVAAGAMGSSHGGPG 2021
Query: 1113 PRTDLETSPGAA----PRTRKTTFGDLLRPPTRPS--RGEELGGAEGDTSSPDPAGRSRP 1166
++ E+SP + P T + G L P P R E+L G + T S A + +P
Sbjct: 2022 DSSEEESSPTSRYIHFPVTVVSAPG--LAPSATPGAPRIEQLDGVDDGTDSEAEAVQ-QP 2078
Query: 1167 RYTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGS 1226
R + ++ LGA D+ RP E +E+ V +L+ +G G
Sbjct: 2079 RGQGTPPSGPGVV----RAGVLGAAGDRARPPEDLPSEI-------VDFVLKNLG-GPGD 2126
Query: 1227 GGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHS-VSADPSCRP---GPGSQ 1282
GGA + + GS +++ A P +RT + + P R GP +
Sbjct: 2127 GGAGPREESLPPAPPLANGSQPSQGLTASPADP----TRTFAWLPGAPGVRVLSLGPAPE 2182
Query: 1283 GPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPS-PDSLGLPEDPCLG 1341
P+ AT K + ++ + G+ + P PP Q P P SP+ P S LP P LG
Sbjct: 2183 PPKPATSKIILVNKLGQVFVKMAGEGE-PVPPPVKQPPLPPTISPTAPTSWTLPPGPLLG 2241
Query: 1342 PRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQR----------SPVLKRRPKL- 1390
G +RP P V +P + +R++R +P + P+L
Sbjct: 2242 VLPVVGVVRPAPPPPPPPLTLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLD 2301
Query: 1391 -------EAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPSPATDQRGGGP 1433
+ P P LGSG + PT + P + GP
Sbjct: 2302 EDGEASEDTPQVPGLGSGGFSRVRMKTPTVRGVLDLDRPGEPAGEESPGP 2351
Score = 44.7 bits (104), Expect = 7e-04
Identities = 118/539 (21%), Positives = 173/539 (32%), Gaps = 154/539 (28%)
Query: 931 EEKEEEKEKDDSPPQKWPELSHGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARG 990
EEK+EE+EKD +K + AEE P AA E+A+ P
Sbjct: 366 EEKKEEEEKDKEGEEKEER------------AVAEEMMP----AAEKEEAKLPPPPLTPP 409
Query: 991 SPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGN 1050
+PSP P PP P+ + P P PPP P PP LP
Sbjct: 410 APSPPPPLPP------------------PSTSPPPPLC-----PPPPPPVSPPPLPSPPP 446
Query: 1051 GLSARVDEGVEEFFSKRLIQQDRLWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRST 1110
P ++ E VP T +K G +P T
Sbjct: 447 -------------------------PPAQEEQEESPPPVVPATCSRKRG------RPPLT 475
Query: 1111 RGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTR 1170
R + E + T PPT P+ GG D SP A P+ T
Sbjct: 476 PSQRAEREAARAGPEGTS---------PPT-PTPSTATGGPPED--SPTVA----PKSTT 519
Query: 1171 DSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAE 1230
K ++P + AR + R + P +V+V S
Sbjct: 520 FLKNIRQFIMPV-----VSARSSRVIKTPRRFMDEDPPKPPKVEV----------SPVLR 564
Query: 1231 GKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWK 1290
S + A + + P+ + + S+ +P+ R W
Sbjct: 565 PPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFR------------WT 612
Query: 1291 TLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTS------------PS---------- 1328
+L ++L + P PP+P P+P +S PS
Sbjct: 613 SLTRELPPPPPAP-------PPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESV 665
Query: 1329 --PDSLGLPEDP-CLGPRNEDGQLRPRPLSAGRR---AVSVHEDQLQAPAERPLRLQRSP 1382
P LG PE P P +D P P + GR ++ + P + + +P
Sbjct: 666 LTPPPLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAP 725
Query: 1383 VLKRRPKLEA---PPSPSLGSGLGTEPLP---PQPTEPSSPERSPPSPATDQRGGGPNP 1435
L P+ +A P +L + L + LP PQ P SP++ PP G G P
Sbjct: 726 ALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVGSLP 784
Score = 31.2 bits (69), Expect = 7.5
Identities = 36/128 (28%), Positives = 47/128 (36%), Gaps = 24/128 (18%)
Query: 956 LVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARG----------SPSPAAP-------- 997
L P A E EPEP P +D+ + P A G +P P
Sbjct: 666 LTPPPLGAPEAPEPEPP---PADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPH 722
Query: 998 GPPA---GPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSA 1054
G PA GP + L Q L+ + P Q +PPP Q+PP G+ +
Sbjct: 723 GAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVGS 782
Query: 1055 RVDEGVEE 1062
GVEE
Sbjct: 783 LPLSGVEE 790
>gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
Length = 488
Score = 53.5 bits (127), Expect = 1e-06
Identities = 54/204 (26%), Positives = 95/204 (46%), Gaps = 12/204 (5%)
Query: 477 DALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLV-CDAGAVSSLDLADNGFGSD 535
+ + +L++ L N +L+++++ S L GA++I D ++ ++ SL+L+ N F D
Sbjct: 148 EGVLSLVEMLQENYYLQEMNI--SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKED 205
Query: 536 MVTLVL-AIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRL 594
L+ A+ + ++ + L N DV + M + L SL ++ +
Sbjct: 206 SAALLCQALSTNYQIKKLDLSHN-------QFSDVGGEHLGQMLAINVGLTSLDLSWNNF 258
Query: 595 KL-GASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLRSVVWDRNHTSALG 653
GA L L N LT LD+S N G+ A L + LR+N L + N G
Sbjct: 259 HTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEG 318
Query: 654 LLDVAQALEQNHSLKAMPLPLNDV 677
+++ LE N SL+ + L LN +
Sbjct: 319 ASKISKGLESNESLRVLKLFLNPI 342
Score = 41.6 bits (96), Expect = 0.006
Identities = 52/220 (23%), Positives = 95/220 (43%), Gaps = 19/220 (8%)
Query: 466 HLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGAVSSL 525
HLGL G ++ D + L+LS + + A ++ + + L
Sbjct: 172 HLGLEGARIISDFFERNSSSI--------WSLELSGNDFKEDSAALLCQALSTNYQIKKL 223
Query: 526 DLADNGF---GSDMVTLVLAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDC 582
DL+ N F G + + +LAI + ++ NF+ R L + L V L + D
Sbjct: 224 DLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWN-NFHTRGAVALCNGLRGNVTLTKLD-- 280
Query: 583 PLQSLSVAESRLKLGASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLRSV 642
S++ + + L +LR N L LDI GN +G+ GA ++K L N LR +
Sbjct: 281 --LSMNGFGNEVALALGEVLRL---NRCLVYLDIGGNDIGNEGASKISKGLESNESLRVL 335
Query: 643 VWDRNHTSALGLLDVAQALEQNHSLKAMPLPLNDVAQAQR 682
N + G + + A+++N + L +++V +++
Sbjct: 336 KLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQ 375
Score = 33.5 bits (75), Expect = 1.5
Identities = 26/117 (22%), Positives = 50/117 (42%), Gaps = 1/117 (0%)
Query: 597 GASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLRSVVWDRNHTSALGLLD 656
G + AL +N +T L++ N + + G L + L+ N L+ + NH G
Sbjct: 121 GTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARI 180
Query: 657 VAQALEQN-HSLKAMPLPLNDVAQAQRSRPELTARAVHQIQACLLRNNRADPASSDH 712
++ E+N S+ ++ L ND + + +QI+ L +N+ +H
Sbjct: 181 ISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEH 237
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 855
Score = 53.1 bits (126), Expect = 2e-06
Identities = 119/521 (22%), Positives = 157/521 (30%), Gaps = 91/521 (17%)
Query: 965 EEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAG-------------PLPRMDLPL 1011
++A+ P A P GSP P P PA PL +
Sbjct: 6 DKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGI 65
Query: 1012 AGQ------PLRHPTRARPRPRRQHHHRPPPGG--PQVPPALPQEGNGLSARVDEGVEEF 1063
G P PTR+ R RPP G + PPA +S+
Sbjct: 66 GGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSS--PGRASGT 123
Query: 1064 FSKRLIQQDRLWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGA 1123
+ Q L E+ G AT P+ G R T GP T SP
Sbjct: 124 TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGAR------RDTSGP-TPGTPSPAM 176
Query: 1124 APRTRKTTFGDLL---------RPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKA 1174
A R+R L RPPT R +E T+ P PA R RP A
Sbjct: 177 ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRP------SA 230
Query: 1175 YSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRK 1234
+ PA + A P P G + +RG+ A
Sbjct: 231 GGGLQRPASRSLSSSATP-LSSPARSGPS-------------------ARGTPRAPAHPS 270
Query: 1235 QSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPG----SQGPESATWK 1290
Q K ++ AP + +S+ P P P SQ P +
Sbjct: 271 QPKPKGLQALRPPQVTPPRKDAAPALG------PLSSSPLATPSPSAALQSQAPPTLPAT 324
Query: 1291 TLGQQLNAELRSRGWGQQDGPG-PPSPGQSPSPCRTSPSP--DSLGLPEDPCLGPRNEDG 1347
L +L + P PPS PSP T PS SLG P
Sbjct: 325 PHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSP 384
Query: 1348 QLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPK-------------LEAPP 1394
L P + ++ LQAP P SP+ P+ PP
Sbjct: 385 PLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPP 444
Query: 1395 SPSLGSGLGTEPLPPQPTEPSSPERSPPSPATDQRGGGPNP 1435
SP + + PP + P ++PPS A P+P
Sbjct: 445 SPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP 485
Score = 41.2 bits (95), Expect = 0.007
Identities = 59/214 (27%), Positives = 76/214 (35%), Gaps = 33/214 (15%)
Query: 844 RGLPELLPEQLL---QDAFTRLRDMRLSITGTLAESIVAQALAGLSAARDQLVESLAQQA 900
+GL L P Q+ +DA L + S T + S Q+ A + SL Q
Sbjct: 275 KGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQL 334
Query: 901 TVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFI 960
+P A P+P P L+ L P +PP + S G +
Sbjct: 335 ATPLPLAPPSPSA-------PPSLQTLPSPPA---------TPPSQ-ATTSLGSPTLQAT 377
Query: 961 HSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGP--------LPRMDLPLA 1012
HS P P L+ P PQA P+ P A P PPA P P+ LA
Sbjct: 378 HSFL----PSPPLS-PLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALA 432
Query: 1013 GQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALP 1046
L+ P P P Q PP P P A P
Sbjct: 433 VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP 466
Score = 40.8 bits (94), Expect = 0.009
Identities = 135/573 (23%), Positives = 182/573 (31%), Gaps = 122/573 (21%)
Query: 874 AESIVAQALAGLSAARDQLVESLAQQATVTMPPALPAPDGGEPSLLEPGELEGLFFPEEK 933
AE VA+ A + R L A++ T P P+P S E+ GL P
Sbjct: 138 AEETVARGKATEAPKRSALSAG-ARRDTSGPTPGTPSPAMARRSRAAGTEV-GLPRPAPS 195
Query: 934 EEEKEKDDSPPQKWPELSHGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAG-------- 985
+ PP + P S + SA+E + EP +P P AG
Sbjct: 196 ARPR-----PPTEGPRKS--------VSSASEHSTTEP---SPAARRRPSAGGGLQRPAS 239
Query: 986 ----PSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQV 1041
SA SPA GP A PR HP++ P+P+ RPP P
Sbjct: 240 RSLSSSATPLSSPARSGPSARGTPRAPA--------HPSQ--PKPKGLQALRPPQVTPPR 289
Query: 1042 PPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDPATEGGATPVPRTLRKKLGTL 1101
A P G S+ + S L Q AP PAT P +L +L T
Sbjct: 290 KDAAPALGPLSSSPLATPSP---SAALQSQ----APPTLPAT-----PHSSSLTCQLATP 337
Query: 1102 FAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPA 1161
P + P SP A P ++ TT L PT + T S P+
Sbjct: 338 LPLAPPSPSAPPSLQTLPSPPATPPSQATTS---LGSPTLQA-----------THSFLPS 383
Query: 1162 GRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIG 1221
P T +A + LP + P PL T + +LQ
Sbjct: 384 PPLSPLATPPPQAPPALALPPLQAPP---SPPASPPLSPLATPSPQAPNALAVHLLQAPF 440
Query: 1222 VSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIK-SRTHSVSADPSCRPGPG 1280
S + + + + S APP+ + S S PS P P
Sbjct: 441 SPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQ 500
Query: 1281 SQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPEDPCL 1340
+ P +A L + P P + P + PSP + P
Sbjct: 501 APPPLAAPPLQLAKP---------------PPQAPPALATPPLQALPSPPA----SFPGQ 541
Query: 1341 GPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGS 1400
P + L PL+ P + P PVL P L+ PPSP
Sbjct: 542 APFSPSASLPMSPLAT-------------PPPQAP------PVLAA-PLLQVPPSP---- 577
Query: 1401 GLGTEPLPPQPTEPSSPERSPPSPATDQRGGGP 1433
P PT R PP+P D GP
Sbjct: 578 -------PASPT--LQAPRRPPTPGPDTSVSGP 601
Score = 40.0 bits (92), Expect = 0.016
Identities = 59/223 (26%), Positives = 78/223 (34%), Gaps = 42/223 (18%)
Query: 958 PFIHSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLR 1017
P SA ++ P LAAP P P A SP+A PP P P PL Q +
Sbjct: 459 PVSPSATPPSQAPPSLAAPPLQVPP--SPPASPPMSPSATPPPQAPPPLAAPPL--QLAK 514
Query: 1018 HPTRARP---RPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRL 1074
P +A P P Q PP P P P +S + + ++ L
Sbjct: 515 PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ---APPVLAAPLL 571
Query: 1075 WAPEEDPATEGGATPVPRTLRKKLGTLFAFKKP------RSTRGPRTDLETSPGAAPRTR 1128
P PA+ TL A ++P S GPR L +PG P
Sbjct: 572 QVPPSPPASP---------------TLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 616
Query: 1129 KTTFGDLLRP------PTRPSRGEELGGAE-----GDTSSPDP 1160
++ L P + S EEL G + G +SP P
Sbjct: 617 RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPP 659
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 53.1 bits (126), Expect = 2e-06
Identities = 80/332 (24%), Positives = 125/332 (37%), Gaps = 63/332 (18%)
Query: 559 NVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRLK-LGASVLLRALATNPNLTALDIS 617
N+R E D +H ++Q +Q C +Q LS+ L G VL L T P L L +S
Sbjct: 62 NLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLS 121
Query: 618 GNAMGDAGAKLLAKA-LRVNSRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLND 676
N +GDAG +LL + L RL + + SA +A L K + + ND
Sbjct: 122 DNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNND 181
Query: 677 VAQAQRSRPELTARAVHQIQACLLRNNRADPASSDHTTRLQPLGLVSDPSEQEVNELCQS 736
+ +A +L D +L+ G+ SD +LC
Sbjct: 182 INEA---------------GVRVLCQGLKDSPCQLEALKLESCGVTSD----NCRDLCGI 222
Query: 737 VQEHVEL--LGCGAGPQGEAAVRQAEDAIQNANFSLSILPILYEAGSSPSHHWQLGQKLE 794
V L L G+ G+ + + + + + L L I W+ G +
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI-----------WECGITAK 271
Query: 795 GLLRQVGEVCR-----QDIQDFTQATLDT----ARSLCPQMLQGSSWREQL--------- 836
G G++CR + +++ + A + AR LC +L+ E L
Sbjct: 272 G----CGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTA 327
Query: 837 ------EGVLAGSRGLPEL-LPEQLLQDAFTR 861
VLA +R L EL + L+DA R
Sbjct: 328 ACCSHFSSVLAQNRFLLELQISNNRLEDAGVR 359
Score = 48.1 bits (113), Expect = 6e-05
Identities = 37/100 (37%), Positives = 48/100 (48%), Gaps = 6/100 (6%)
Query: 247 LEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGAL 306
LE L LE+C + D R L +A S + LREL+L N L D GM L L L
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVA--SKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Query: 307 RRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGN 346
R L + + G+T +G L R L +L L L+GN
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAK----ESLKELSLAGN 294
Score = 44.7 bits (104), Expect = 7e-04
Identities = 82/334 (24%), Positives = 131/334 (39%), Gaps = 29/334 (8%)
Query: 240 MMSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHL 299
++ LE+L LE CSL LA L + +EL+++ N +++ G+ L + L
Sbjct: 137 LLDPQCRLEKLQLEYCSLSAASCEPLASVL--RAKPDFKELTVSNNDINEAGVRVLCQGL 194
Query: 300 ERCPGALRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNP-GALGASEDSGG 358
+ P L L L G+T R L +A+ A +L L L N G +G +E G
Sbjct: 195 KDSPCQLEALKLESCGVTSDNCRDLCGIVASKA----SLRELALGSNKLGDVGMAELCPG 250
Query: 359 LYSFLSRPNVLSFL----------NLAGTDTALDTVRGCSVGGWMTGRADWRAGRGGLGP 408
L SR L +L A ++++ S+ G G R L
Sbjct: 251 LLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLE 310
Query: 409 PAGVANSLPPQLFAAVSRGCCTSLTHLDASRNVF-------SRTKSRAAPAALQLFLSRA 461
P SL + + + CC+ + + A +R + Q
Sbjct: 311 PGCQLESLWVK-SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
Query: 462 RTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGA 521
LR L LA C + + +L L N LR+ LDLS L AG + + V G
Sbjct: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRE--LDLSNNCLGDAGILQLVESVRQPGC 427
Query: 522 -VSSLDLADNGFGSDMVTLVLAIGRSR-SLRHVA 553
+ L L D + +M + A+ + + SLR ++
Sbjct: 428 LLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
Score = 41.2 bits (95), Expect = 0.007
Identities = 56/221 (25%), Positives = 93/221 (42%), Gaps = 12/221 (5%)
Query: 464 LRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAG-AQVIQDLVCDAGAV 522
L L L C + D R L +A LR+L L + +L G A++ L+ + +
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN--KLGDVGMAELCPGLLHPSSRL 258
Query: 523 SSLDLADNGFGSDMVTLVLAIGRSR-SLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDD 581
+L + + G + + + R++ SL+ ++L N E D+ + + + +
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN------ELGDEGARLLCETLLEPG 312
Query: 582 CPLQSLSVAESRLKLGA-SVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLR 640
C L+SL V S LA N L L IS N + DAG + L + L +
Sbjct: 313 CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372
Query: 641 SVVWDRN-HTSALGLLDVAQALEQNHSLKAMPLPLNDVAQA 680
V+W + S +A L NHSL+ + L N + A
Sbjct: 373 RVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Score = 35.0 bits (79), Expect = 0.52
Identities = 89/401 (22%), Positives = 146/401 (36%), Gaps = 63/401 (15%)
Query: 240 MMSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHL 299
+ + S +++L L+ C L G L+ L + L+EL L+ NLL D G+ L L
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTL--RTLPTLQELHLSDNLLGDAGLQLLCEGL 137
Query: 300 ERCPGALRRLSLAQTGLTPRGMRALGRALATNAAF-DSTLTHLDLSGNPGALGASEDSGG 358
L +L L L+ L L F + T+++ D++ G G
Sbjct: 138 LDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN----EAGVRVLCQG 193
Query: 359 LYSFLSRPNVLSFLNLAGTDTALDTVRG-CSVGGWMTGRADWRAGRGGLGPPAGVANSLP 417
L P L L L D R C + + G LG G+A
Sbjct: 194 L---KDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG-DVGMAE--- 246
Query: 418 PQLFAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPD 477
C L H +SR LR L + C +
Sbjct: 247 ----------LCPGLLH-PSSR------------------------LRTLWIWECGITAK 271
Query: 478 ALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGA-VSSLDLADNGFGSDM 536
L L L++ L L+ EL GA+++ + + + G + SL + F +
Sbjct: 272 GCGDLCRVLRAKESLKE--LSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAAC 329
Query: 537 VT-LVLAIGRSRSLRHVALGRNFNVRCKETLDDV-LHRIVQLMQDDDCPLQSLSVAESRL 594
+ + ++R L + + N L+D + + Q + L+ L +A+ +
Sbjct: 330 CSHFSSVLAQNRFLLELQISNN-------RLEDAGVRELCQGLGQPGSVLRVLWLADCDV 382
Query: 595 K-LGASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALR 634
S L L N +L LD+S N +GDAG L +++R
Sbjct: 383 SDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVR 423
Score = 33.1 bits (74), Expect = 2.0
Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 15/88 (17%)
Query: 556 RNFNVRCKETLDDVLHRIVQLMQD------DDCPLQSLSVAESRLKLGASVLLRALATNP 609
++ +++C+E D ++ L+Q DDC L E+R K +S AL NP
Sbjct: 6 QSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGL-----TEARCKDISS----ALRVNP 56
Query: 610 NLTALDISGNAMGDAGAKLLAKALRVNS 637
L L++ N +GD G + + L+ S
Sbjct: 57 ALAELNLRSNELGDVGVHCVLQGLQTPS 84
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 53.1 bits (126), Expect = 2e-06
Identities = 80/332 (24%), Positives = 125/332 (37%), Gaps = 63/332 (18%)
Query: 559 NVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRLK-LGASVLLRALATNPNLTALDIS 617
N+R E D +H ++Q +Q C +Q LS+ L G VL L T P L L +S
Sbjct: 62 NLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLS 121
Query: 618 GNAMGDAGAKLLAKA-LRVNSRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLND 676
N +GDAG +LL + L RL + + SA +A L K + + ND
Sbjct: 122 DNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNND 181
Query: 677 VAQAQRSRPELTARAVHQIQACLLRNNRADPASSDHTTRLQPLGLVSDPSEQEVNELCQS 736
+ +A +L D +L+ G+ SD +LC
Sbjct: 182 INEA---------------GVRVLCQGLKDSPCQLEALKLESCGVTSD----NCRDLCGI 222
Query: 737 VQEHVEL--LGCGAGPQGEAAVRQAEDAIQNANFSLSILPILYEAGSSPSHHWQLGQKLE 794
V L L G+ G+ + + + + + L L I W+ G +
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI-----------WECGITAK 271
Query: 795 GLLRQVGEVCR-----QDIQDFTQATLDT----ARSLCPQMLQGSSWREQL--------- 836
G G++CR + +++ + A + AR LC +L+ E L
Sbjct: 272 G----CGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTA 327
Query: 837 ------EGVLAGSRGLPEL-LPEQLLQDAFTR 861
VLA +R L EL + L+DA R
Sbjct: 328 ACCSHFSSVLAQNRFLLELQISNNRLEDAGVR 359
Score = 48.1 bits (113), Expect = 6e-05
Identities = 37/100 (37%), Positives = 48/100 (48%), Gaps = 6/100 (6%)
Query: 247 LEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGAL 306
LE L LE+C + D R L +A S + LREL+L N L D GM L L L
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVA--SKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Query: 307 RRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGN 346
R L + + G+T +G L R L +L L L+GN
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAK----ESLKELSLAGN 294
Score = 44.7 bits (104), Expect = 7e-04
Identities = 82/334 (24%), Positives = 131/334 (39%), Gaps = 29/334 (8%)
Query: 240 MMSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHL 299
++ LE+L LE CSL LA L + +EL+++ N +++ G+ L + L
Sbjct: 137 LLDPQCRLEKLQLEYCSLSAASCEPLASVL--RAKPDFKELTVSNNDINEAGVRVLCQGL 194
Query: 300 ERCPGALRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNP-GALGASEDSGG 358
+ P L L L G+T R L +A+ A +L L L N G +G +E G
Sbjct: 195 KDSPCQLEALKLESCGVTSDNCRDLCGIVASKA----SLRELALGSNKLGDVGMAELCPG 250
Query: 359 LYSFLSRPNVLSFL----------NLAGTDTALDTVRGCSVGGWMTGRADWRAGRGGLGP 408
L SR L +L A ++++ S+ G G R L
Sbjct: 251 LLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLE 310
Query: 409 PAGVANSLPPQLFAAVSRGCCTSLTHLDASRNVF-------SRTKSRAAPAALQLFLSRA 461
P SL + + + CC+ + + A +R + Q
Sbjct: 311 PGCQLESLWVK-SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
Query: 462 RTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGA 521
LR L LA C + + +L L N LR+ LDLS L AG + + V G
Sbjct: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRE--LDLSNNCLGDAGILQLVESVRQPGC 427
Query: 522 -VSSLDLADNGFGSDMVTLVLAIGRSR-SLRHVA 553
+ L L D + +M + A+ + + SLR ++
Sbjct: 428 LLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
Score = 41.2 bits (95), Expect = 0.007
Identities = 56/221 (25%), Positives = 93/221 (42%), Gaps = 12/221 (5%)
Query: 464 LRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAG-AQVIQDLVCDAGAV 522
L L L C + D R L +A LR+L L + +L G A++ L+ + +
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN--KLGDVGMAELCPGLLHPSSRL 258
Query: 523 SSLDLADNGFGSDMVTLVLAIGRSR-SLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDD 581
+L + + G + + + R++ SL+ ++L N E D+ + + + +
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN------ELGDEGARLLCETLLEPG 312
Query: 582 CPLQSLSVAESRLKLGA-SVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLR 640
C L+SL V S LA N L L IS N + DAG + L + L +
Sbjct: 313 CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372
Query: 641 SVVWDRN-HTSALGLLDVAQALEQNHSLKAMPLPLNDVAQA 680
V+W + S +A L NHSL+ + L N + A
Sbjct: 373 RVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Score = 35.0 bits (79), Expect = 0.52
Identities = 89/401 (22%), Positives = 146/401 (36%), Gaps = 63/401 (15%)
Query: 240 MMSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHL 299
+ + S +++L L+ C L G L+ L + L+EL L+ NLL D G+ L L
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTL--RTLPTLQELHLSDNLLGDAGLQLLCEGL 137
Query: 300 ERCPGALRRLSLAQTGLTPRGMRALGRALATNAAF-DSTLTHLDLSGNPGALGASEDSGG 358
L +L L L+ L L F + T+++ D++ G G
Sbjct: 138 LDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN----EAGVRVLCQG 193
Query: 359 LYSFLSRPNVLSFLNLAGTDTALDTVRG-CSVGGWMTGRADWRAGRGGLGPPAGVANSLP 417
L P L L L D R C + + G LG G+A
Sbjct: 194 L---KDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG-DVGMAE--- 246
Query: 418 PQLFAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPD 477
C L H +SR LR L + C +
Sbjct: 247 ----------LCPGLLH-PSSR------------------------LRTLWIWECGITAK 271
Query: 478 ALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGA-VSSLDLADNGFGSDM 536
L L L++ L L+ EL GA+++ + + + G + SL + F +
Sbjct: 272 GCGDLCRVLRAKESLKE--LSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAAC 329
Query: 537 VT-LVLAIGRSRSLRHVALGRNFNVRCKETLDDV-LHRIVQLMQDDDCPLQSLSVAESRL 594
+ + ++R L + + N L+D + + Q + L+ L +A+ +
Sbjct: 330 CSHFSSVLAQNRFLLELQISNN-------RLEDAGVRELCQGLGQPGSVLRVLWLADCDV 382
Query: 595 K-LGASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALR 634
S L L N +L LD+S N +GDAG L +++R
Sbjct: 383 SDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVR 423
Score = 33.1 bits (74), Expect = 2.0
Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 15/88 (17%)
Query: 556 RNFNVRCKETLDDVLHRIVQLMQD------DDCPLQSLSVAESRLKLGASVLLRALATNP 609
++ +++C+E D ++ L+Q DDC L E+R K +S AL NP
Sbjct: 6 QSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGL-----TEARCKDISS----ALRVNP 56
Query: 610 NLTALDISGNAMGDAGAKLLAKALRVNS 637
L L++ N +GD G + + L+ S
Sbjct: 57 ALAELNLRSNELGDVGVHCVLQGLQTPS 84
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 53.1 bits (126), Expect = 2e-06
Identities = 80/332 (24%), Positives = 125/332 (37%), Gaps = 63/332 (18%)
Query: 559 NVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRLK-LGASVLLRALATNPNLTALDIS 617
N+R E D +H ++Q +Q C +Q LS+ L G VL L T P L L +S
Sbjct: 62 NLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLS 121
Query: 618 GNAMGDAGAKLLAKA-LRVNSRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLND 676
N +GDAG +LL + L RL + + SA +A L K + + ND
Sbjct: 122 DNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNND 181
Query: 677 VAQAQRSRPELTARAVHQIQACLLRNNRADPASSDHTTRLQPLGLVSDPSEQEVNELCQS 736
+ +A +L D +L+ G+ SD +LC
Sbjct: 182 INEA---------------GVRVLCQGLKDSPCQLEALKLESCGVTSD----NCRDLCGI 222
Query: 737 VQEHVEL--LGCGAGPQGEAAVRQAEDAIQNANFSLSILPILYEAGSSPSHHWQLGQKLE 794
V L L G+ G+ + + + + + L L I W+ G +
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI-----------WECGITAK 271
Query: 795 GLLRQVGEVCR-----QDIQDFTQATLDT----ARSLCPQMLQGSSWREQL--------- 836
G G++CR + +++ + A + AR LC +L+ E L
Sbjct: 272 G----CGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTA 327
Query: 837 ------EGVLAGSRGLPEL-LPEQLLQDAFTR 861
VLA +R L EL + L+DA R
Sbjct: 328 ACCSHFSSVLAQNRFLLELQISNNRLEDAGVR 359
Score = 48.1 bits (113), Expect = 6e-05
Identities = 37/100 (37%), Positives = 48/100 (48%), Gaps = 6/100 (6%)
Query: 247 LEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGAL 306
LE L LE+C + D R L +A S + LREL+L N L D GM L L L
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVA--SKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Query: 307 RRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGN 346
R L + + G+T +G L R L +L L L+GN
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAK----ESLKELSLAGN 294
Score = 44.7 bits (104), Expect = 7e-04
Identities = 82/334 (24%), Positives = 131/334 (39%), Gaps = 29/334 (8%)
Query: 240 MMSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHL 299
++ LE+L LE CSL LA L + +EL+++ N +++ G+ L + L
Sbjct: 137 LLDPQCRLEKLQLEYCSLSAASCEPLASVL--RAKPDFKELTVSNNDINEAGVRVLCQGL 194
Query: 300 ERCPGALRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNP-GALGASEDSGG 358
+ P L L L G+T R L +A+ A +L L L N G +G +E G
Sbjct: 195 KDSPCQLEALKLESCGVTSDNCRDLCGIVASKA----SLRELALGSNKLGDVGMAELCPG 250
Query: 359 LYSFLSRPNVLSFL----------NLAGTDTALDTVRGCSVGGWMTGRADWRAGRGGLGP 408
L SR L +L A ++++ S+ G G R L
Sbjct: 251 LLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLE 310
Query: 409 PAGVANSLPPQLFAAVSRGCCTSLTHLDASRNVF-------SRTKSRAAPAALQLFLSRA 461
P SL + + + CC+ + + A +R + Q
Sbjct: 311 PGCQLESLWVK-SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
Query: 462 RTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGA 521
LR L LA C + + +L L N LR+ LDLS L AG + + V G
Sbjct: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRE--LDLSNNCLGDAGILQLVESVRQPGC 427
Query: 522 -VSSLDLADNGFGSDMVTLVLAIGRSR-SLRHVA 553
+ L L D + +M + A+ + + SLR ++
Sbjct: 428 LLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
Score = 41.2 bits (95), Expect = 0.007
Identities = 56/221 (25%), Positives = 93/221 (42%), Gaps = 12/221 (5%)
Query: 464 LRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAG-AQVIQDLVCDAGAV 522
L L L C + D R L +A LR+L L + +L G A++ L+ + +
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN--KLGDVGMAELCPGLLHPSSRL 258
Query: 523 SSLDLADNGFGSDMVTLVLAIGRSR-SLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDD 581
+L + + G + + + R++ SL+ ++L N E D+ + + + +
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN------ELGDEGARLLCETLLEPG 312
Query: 582 CPLQSLSVAESRLKLGA-SVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLR 640
C L+SL V S LA N L L IS N + DAG + L + L +
Sbjct: 313 CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372
Query: 641 SVVWDRN-HTSALGLLDVAQALEQNHSLKAMPLPLNDVAQA 680
V+W + S +A L NHSL+ + L N + A
Sbjct: 373 RVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Score = 35.0 bits (79), Expect = 0.52
Identities = 89/401 (22%), Positives = 146/401 (36%), Gaps = 63/401 (15%)
Query: 240 MMSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHL 299
+ + S +++L L+ C L G L+ L + L+EL L+ NLL D G+ L L
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTL--RTLPTLQELHLSDNLLGDAGLQLLCEGL 137
Query: 300 ERCPGALRRLSLAQTGLTPRGMRALGRALATNAAF-DSTLTHLDLSGNPGALGASEDSGG 358
L +L L L+ L L F + T+++ D++ G G
Sbjct: 138 LDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN----EAGVRVLCQG 193
Query: 359 LYSFLSRPNVLSFLNLAGTDTALDTVRG-CSVGGWMTGRADWRAGRGGLGPPAGVANSLP 417
L P L L L D R C + + G LG G+A
Sbjct: 194 L---KDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG-DVGMAE--- 246
Query: 418 PQLFAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPD 477
C L H +SR LR L + C +
Sbjct: 247 ----------LCPGLLH-PSSR------------------------LRTLWIWECGITAK 271
Query: 478 ALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGA-VSSLDLADNGFGSDM 536
L L L++ L L+ EL GA+++ + + + G + SL + F +
Sbjct: 272 GCGDLCRVLRAKESLKE--LSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAAC 329
Query: 537 VT-LVLAIGRSRSLRHVALGRNFNVRCKETLDDV-LHRIVQLMQDDDCPLQSLSVAESRL 594
+ + ++R L + + N L+D + + Q + L+ L +A+ +
Sbjct: 330 CSHFSSVLAQNRFLLELQISNN-------RLEDAGVRELCQGLGQPGSVLRVLWLADCDV 382
Query: 595 K-LGASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALR 634
S L L N +L LD+S N +GDAG L +++R
Sbjct: 383 SDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVR 423
Score = 33.1 bits (74), Expect = 2.0
Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 15/88 (17%)
Query: 556 RNFNVRCKETLDDVLHRIVQLMQD------DDCPLQSLSVAESRLKLGASVLLRALATNP 609
++ +++C+E D ++ L+Q DDC L E+R K +S AL NP
Sbjct: 6 QSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGL-----TEARCKDISS----ALRVNP 56
Query: 610 NLTALDISGNAMGDAGAKLLAKALRVNS 637
L L++ N +GD G + + L+ S
Sbjct: 57 ALAELNLRSNELGDVGVHCVLQGLQTPS 84
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 53.1 bits (126), Expect = 2e-06
Identities = 80/332 (24%), Positives = 125/332 (37%), Gaps = 63/332 (18%)
Query: 559 NVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRLK-LGASVLLRALATNPNLTALDIS 617
N+R E D +H ++Q +Q C +Q LS+ L G VL L T P L L +S
Sbjct: 62 NLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLS 121
Query: 618 GNAMGDAGAKLLAKA-LRVNSRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLND 676
N +GDAG +LL + L RL + + SA +A L K + + ND
Sbjct: 122 DNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNND 181
Query: 677 VAQAQRSRPELTARAVHQIQACLLRNNRADPASSDHTTRLQPLGLVSDPSEQEVNELCQS 736
+ +A +L D +L+ G+ SD +LC
Sbjct: 182 INEA---------------GVRVLCQGLKDSPCQLEALKLESCGVTSD----NCRDLCGI 222
Query: 737 VQEHVEL--LGCGAGPQGEAAVRQAEDAIQNANFSLSILPILYEAGSSPSHHWQLGQKLE 794
V L L G+ G+ + + + + + L L I W+ G +
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI-----------WECGITAK 271
Query: 795 GLLRQVGEVCR-----QDIQDFTQATLDT----ARSLCPQMLQGSSWREQL--------- 836
G G++CR + +++ + A + AR LC +L+ E L
Sbjct: 272 G----CGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTA 327
Query: 837 ------EGVLAGSRGLPEL-LPEQLLQDAFTR 861
VLA +R L EL + L+DA R
Sbjct: 328 ACCSHFSSVLAQNRFLLELQISNNRLEDAGVR 359
Score = 48.1 bits (113), Expect = 6e-05
Identities = 37/100 (37%), Positives = 48/100 (48%), Gaps = 6/100 (6%)
Query: 247 LEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGAL 306
LE L LE+C + D R L +A S + LREL+L N L D GM L L L
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVA--SKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Query: 307 RRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGN 346
R L + + G+T +G L R L +L L L+GN
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAK----ESLKELSLAGN 294
Score = 44.7 bits (104), Expect = 7e-04
Identities = 82/334 (24%), Positives = 131/334 (39%), Gaps = 29/334 (8%)
Query: 240 MMSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHL 299
++ LE+L LE CSL LA L + +EL+++ N +++ G+ L + L
Sbjct: 137 LLDPQCRLEKLQLEYCSLSAASCEPLASVL--RAKPDFKELTVSNNDINEAGVRVLCQGL 194
Query: 300 ERCPGALRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNP-GALGASEDSGG 358
+ P L L L G+T R L +A+ A +L L L N G +G +E G
Sbjct: 195 KDSPCQLEALKLESCGVTSDNCRDLCGIVASKA----SLRELALGSNKLGDVGMAELCPG 250
Query: 359 LYSFLSRPNVLSFL----------NLAGTDTALDTVRGCSVGGWMTGRADWRAGRGGLGP 408
L SR L +L A ++++ S+ G G R L
Sbjct: 251 LLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLE 310
Query: 409 PAGVANSLPPQLFAAVSRGCCTSLTHLDASRNVF-------SRTKSRAAPAALQLFLSRA 461
P SL + + + CC+ + + A +R + Q
Sbjct: 311 PGCQLESLWVK-SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
Query: 462 RTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGA 521
LR L LA C + + +L L N LR+ LDLS L AG + + V G
Sbjct: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRE--LDLSNNCLGDAGILQLVESVRQPGC 427
Query: 522 -VSSLDLADNGFGSDMVTLVLAIGRSR-SLRHVA 553
+ L L D + +M + A+ + + SLR ++
Sbjct: 428 LLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
Score = 41.2 bits (95), Expect = 0.007
Identities = 56/221 (25%), Positives = 93/221 (42%), Gaps = 12/221 (5%)
Query: 464 LRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAG-AQVIQDLVCDAGAV 522
L L L C + D R L +A LR+L L + +L G A++ L+ + +
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN--KLGDVGMAELCPGLLHPSSRL 258
Query: 523 SSLDLADNGFGSDMVTLVLAIGRSR-SLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDD 581
+L + + G + + + R++ SL+ ++L N E D+ + + + +
Sbjct: 259 RTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN------ELGDEGARLLCETLLEPG 312
Query: 582 CPLQSLSVAESRLKLGA-SVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLR 640
C L+SL V S LA N L L IS N + DAG + L + L +
Sbjct: 313 CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372
Query: 641 SVVWDRN-HTSALGLLDVAQALEQNHSLKAMPLPLNDVAQA 680
V+W + S +A L NHSL+ + L N + A
Sbjct: 373 RVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Score = 35.0 bits (79), Expect = 0.52
Identities = 89/401 (22%), Positives = 146/401 (36%), Gaps = 63/401 (15%)
Query: 240 MMSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHL 299
+ + S +++L L+ C L G L+ L + L+EL L+ NLL D G+ L L
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTL--RTLPTLQELHLSDNLLGDAGLQLLCEGL 137
Query: 300 ERCPGALRRLSLAQTGLTPRGMRALGRALATNAAF-DSTLTHLDLSGNPGALGASEDSGG 358
L +L L L+ L L F + T+++ D++ G G
Sbjct: 138 LDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN----EAGVRVLCQG 193
Query: 359 LYSFLSRPNVLSFLNLAGTDTALDTVRG-CSVGGWMTGRADWRAGRGGLGPPAGVANSLP 417
L P L L L D R C + + G LG G+A
Sbjct: 194 L---KDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG-DVGMAE--- 246
Query: 418 PQLFAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPD 477
C L H +SR LR L + C +
Sbjct: 247 ----------LCPGLLH-PSSR------------------------LRTLWIWECGITAK 271
Query: 478 ALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGA-VSSLDLADNGFGSDM 536
L L L++ L L+ EL GA+++ + + + G + SL + F +
Sbjct: 272 GCGDLCRVLRAKESLKE--LSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAAC 329
Query: 537 VT-LVLAIGRSRSLRHVALGRNFNVRCKETLDDV-LHRIVQLMQDDDCPLQSLSVAESRL 594
+ + ++R L + + N L+D + + Q + L+ L +A+ +
Sbjct: 330 CSHFSSVLAQNRFLLELQISNN-------RLEDAGVRELCQGLGQPGSVLRVLWLADCDV 382
Query: 595 K-LGASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALR 634
S L L N +L LD+S N +GDAG L +++R
Sbjct: 383 SDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVR 423
Score = 33.1 bits (74), Expect = 2.0
Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 15/88 (17%)
Query: 556 RNFNVRCKETLDDVLHRIVQLMQD------DDCPLQSLSVAESRLKLGASVLLRALATNP 609
++ +++C+E D ++ L+Q DDC L E+R K +S AL NP
Sbjct: 6 QSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGL-----TEARCKDISS----ALRVNP 56
Query: 610 NLTALDISGNAMGDAGAKLLAKALRVNS 637
L L++ N +GD G + + L+ S
Sbjct: 57 ALAELNLRSNELGDVGVHCVLQGLQTPS 84
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,153,166
Number of Sequences: 37866
Number of extensions: 3965117
Number of successful extensions: 38929
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 195
Number of HSP's successfully gapped in prelim test: 1490
Number of HSP's that attempted gapping in prelim test: 24579
Number of HSP's gapped (non-prelim): 12154
length of query: 1435
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1320
effective length of database: 13,892,928
effective search space: 18338664960
effective search space used: 18338664960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.