Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 66346695

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|66346695 fibrillin 2 precursor [Homo sapiens]
         (2912 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|66346695 fibrillin 2 precursor [Homo sapiens]                     6509   0.0  
gi|24430141 fibrillin 1 precursor [Homo sapiens]                     4586   0.0  
gi|56237021 fibrillin 3 precursor [Homo sapiens]                     4452   0.0  
gi|110347437 latent transforming growth factor beta binding prot...   524   e-148
gi|110347412 latent transforming growth factor beta binding prot...   524   e-148
gi|110347431 latent transforming growth factor beta binding prot...   524   e-148
gi|4557733 latent transforming growth factor beta binding protei...   494   e-139
gi|24041035 notch 2 preproprotein [Homo sapiens]                      489   e-137
gi|148833508 notch1 preproprotein [Homo sapiens]                      473   e-133
gi|46249414 latent transforming growth factor beta binding prote...   472   e-132
gi|46249412 latent transforming growth factor beta binding prote...   472   e-132
gi|134244285 Notch homolog 3 [Homo sapiens]                           461   e-129
gi|18497288 latent transforming growth factor beta binding prote...   441   e-123
gi|194328809 latent transforming growth factor beta binding prot...   432   e-120
gi|55770876 notch4 preproprotein [Homo sapiens]                       315   4e-85
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               304   7e-82
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]              276   2e-73
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]             276   3e-73
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]             276   3e-73
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]              266   2e-70
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]    254   1e-66
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]               246   2e-64
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]               242   4e-63
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]              235   4e-61
gi|34734066 fibulin 1 isoform D [Homo sapiens]                        234   1e-60
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]               233   2e-60
gi|118572606 hemicentin 1 [Homo sapiens]                              232   4e-60
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]              231   8e-60
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]              231   8e-60
gi|10190748 CEGP1 protein [Homo sapiens]                              228   7e-59

>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score = 6509 bits (16887), Expect = 0.0
 Identities = 2912/2912 (100%), Positives = 2912/2912 (100%)

Query: 1    MGRRRRLCLQLYFLWLGCVVLWAQGTAGQPQPPPPKPPRPQPPPQQVRSATAGSEGGFLA 60
            MGRRRRLCLQLYFLWLGCVVLWAQGTAGQPQPPPPKPPRPQPPPQQVRSATAGSEGGFLA
Sbjct: 1    MGRRRRLCLQLYFLWLGCVVLWAQGTAGQPQPPPPKPPRPQPPPQQVRSATAGSEGGFLA 60

Query: 61   PEYREEGAAVASRVRRRGQQDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCG 120
            PEYREEGAAVASRVRRRGQQDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCG
Sbjct: 61   PEYREEGAAVASRVRRRGQQDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCG 120

Query: 121  DGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVC 180
            DGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVC
Sbjct: 121  DGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVC 180

Query: 181  ENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCC 240
            ENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCC
Sbjct: 181  ENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCC 240

Query: 241  ATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFE 300
            ATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFE
Sbjct: 241  ATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFE 300

Query: 301  CRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCID 360
            CRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCID
Sbjct: 301  CRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCID 360

Query: 361  QRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDG 420
            QRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDG
Sbjct: 361  QRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDG 420

Query: 421  LPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGG 480
            LPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGG
Sbjct: 421  LPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGG 480

Query: 481  QGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECT 540
            QGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECT
Sbjct: 481  QGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECT 540

Query: 541  SNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQC 600
            SNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQC
Sbjct: 541  SNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQC 600

Query: 601  ICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVD 660
            ICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVD
Sbjct: 601  ICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVD 660

Query: 661  ECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFP 720
            ECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFP
Sbjct: 661  ECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFP 720

Query: 721  GAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICA 780
            GAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICA
Sbjct: 721  GAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICA 780

Query: 781  NGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPG 840
            NGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPG
Sbjct: 781  NGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPG 840

Query: 841  YVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWL 900
            YVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWL
Sbjct: 841  YVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWL 900

Query: 901  NIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECE 960
            NIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECE
Sbjct: 901  NIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECE 960

Query: 961  VFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKF 1020
            VFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKF
Sbjct: 961  VFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKF 1020

Query: 1021 RMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAF 1080
            RMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAF
Sbjct: 1021 RMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAF 1080

Query: 1081 PGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFEC 1140
            PGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFEC
Sbjct: 1081 PGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFEC 1140

Query: 1141 ECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVD 1200
            ECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVD
Sbjct: 1141 ECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVD 1200

Query: 1201 INECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNS 1260
            INECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNS
Sbjct: 1201 INECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNS 1260

Query: 1261 EGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDM 1320
            EGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDM
Sbjct: 1261 EGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDM 1320

Query: 1321 KTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDM 1380
            KTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDM
Sbjct: 1321 KTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDM 1380

Query: 1381 HASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF 1440
            HASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF
Sbjct: 1381 HASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF 1440

Query: 1441 TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNI 1500
            TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNI
Sbjct: 1441 TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNI 1500

Query: 1501 CVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPP 1560
            CVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPP
Sbjct: 1501 CVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPP 1560

Query: 1561 DFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCET 1620
            DFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCET
Sbjct: 1561 DFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCET 1620

Query: 1621 CPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQG 1680
            CPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQG
Sbjct: 1621 CPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQG 1680

Query: 1681 YYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFC 1740
            YYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFC
Sbjct: 1681 YYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFC 1740

Query: 1741 YRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFD 1800
            YRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFD
Sbjct: 1741 YRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFD 1800

Query: 1801 IHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNL 1860
            IHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNL
Sbjct: 1801 IHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNL 1860

Query: 1861 CQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICH 1920
            CQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICH
Sbjct: 1861 CQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICH 1920

Query: 1921 NGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSF 1980
            NGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSF
Sbjct: 1921 NGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSF 1980

Query: 1981 FGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFR 2040
            FGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFR
Sbjct: 1981 FGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFR 2040

Query: 2041 CICPPGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR 2100
            CICPPGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR
Sbjct: 2041 CICPPGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR 2100

Query: 2101 QSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHG 2160
            QSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHG
Sbjct: 2101 QSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHG 2160

Query: 2161 TVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIG 2220
            TVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIG
Sbjct: 2161 TVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIG 2220

Query: 2221 NPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCP 2280
            NPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCP
Sbjct: 2221 NPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCP 2280

Query: 2281 IGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDEN 2340
            IGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDEN
Sbjct: 2281 IGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDEN 2340

Query: 2341 ECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASS 2400
            ECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASS
Sbjct: 2341 ECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASS 2400

Query: 2401 SRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLC 2460
            SRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLC
Sbjct: 2401 SRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLC 2460

Query: 2461 TNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRG 2520
            TNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRG
Sbjct: 2461 TNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRG 2520

Query: 2521 YVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPS 2580
            YVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPS
Sbjct: 2521 YVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPS 2580

Query: 2581 LCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCP 2640
            LCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCP
Sbjct: 2581 LCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCP 2640

Query: 2641 QGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECS 2700
            QGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECS
Sbjct: 2641 QGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECS 2700

Query: 2701 SSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPE 2760
            SSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPE
Sbjct: 2701 SSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPE 2760

Query: 2761 ACYECKINGYSKKDSRQKRSIHEPDPTAVEQISLESVDMDSPVNMKFNLSHLGSKEHILE 2820
            ACYECKINGYSKKDSRQKRSIHEPDPTAVEQISLESVDMDSPVNMKFNLSHLGSKEHILE
Sbjct: 2761 ACYECKINGYSKKDSRQKRSIHEPDPTAVEQISLESVDMDSPVNMKFNLSHLGSKEHILE 2820

Query: 2821 LRPAIQPLNNHIRYVISQGNDDSVFRIHQRNGLSYLHTAKKKLMPGTYTLEITSIPLYKK 2880
            LRPAIQPLNNHIRYVISQGNDDSVFRIHQRNGLSYLHTAKKKLMPGTYTLEITSIPLYKK
Sbjct: 2821 LRPAIQPLNNHIRYVISQGNDDSVFRIHQRNGLSYLHTAKKKLMPGTYTLEITSIPLYKK 2880

Query: 2881 KELKKLEESNEDDYLLGELGEALRMRLQIQLY 2912
            KELKKLEESNEDDYLLGELGEALRMRLQIQLY
Sbjct: 2881 KELKKLEESNEDDYLLGELGEALRMRLQIQLY 2912


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score = 4586 bits (11896), Expect = 0.0
 Identities = 1972/2867 (68%), Positives = 2342/2867 (81%), Gaps = 59/2867 (2%)

Query: 71   ASRVRRRGQ--QDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPN 128
            ASR +RRG    D L+GPNVCGSR+++YCCPGWKTLPGGNQCIVPICR+SCGDGFCSRPN
Sbjct: 39   ASRAKRRGGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPN 98

Query: 129  MCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGG 188
            MCTC SGQI+ +CGS+SIQ C++RCMNGG+C+DDHC CQKGYIGT+CGQPVCE+GC NGG
Sbjct: 99   MCTCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGG 158

Query: 189  RCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWG 248
            RC+ PNRCAC YGFTGPQCERDYRTGPCFT ++NQMCQGQL+GIVCTKTLCCAT+GRAWG
Sbjct: 159  RCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWG 218

Query: 249  HPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHK 308
            HPCEMCPAQP PCRRGFIPNIRTGACQDVDECQAIPG+CQGGNCINTVGSFEC+CPAGHK
Sbjct: 219  HPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHK 278

Query: 309  QSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFS 368
             +E +QKCEDIDECS IPGICE GEC+NTV SYFC CP G+ TS DG+RCID R G C++
Sbjct: 279  LNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYT 338

Query: 369  GLVNGRCAQELPGRMTKMQCCCEPGRCW--GIGTIPEACPVRGSEEYRRLCMDGLPMGGI 426
             L NGRC+ +LP  +TKMQCCC+ GRCW  G+   PE CP+R +E++ +LC   +PM  I
Sbjct: 339  ALTNGRCSNQLPQSITKMQCCCDAGRCWSPGVTVAPEMCPIRATEDFNKLC--SVPMV-I 395

Query: 427  PGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIP--IPGGNGFSPG----VGGAGVG--- 477
            PG    RP                Y P   G IP  +P   GF PG    V    V    
Sbjct: 396  PG----RPE---------------YPPPPLGPIPPVLPVPPGFPPGPQIPVPRPPVEYLY 436

Query: 478  AGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVD 537
               + P +  + +     D C+    LC NGRCIPT  S RCECN G++ D  G+CIDVD
Sbjct: 437  PSREPPRVLPVNVT----DYCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVD 492

Query: 538  ECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGS 597
            EC  NPC  G+C+N  GSY C+C AG+Q T T+  C DIDEC+QNG +C NGRC+NTDGS
Sbjct: 493  ECEKNPCAGGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGS 552

Query: 598  FQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCT 657
            F C+CNAGF +T DGKNC D DEC+  NMCLNGMCINEDGSFKCICKPGF LA +GRYC 
Sbjct: 553  FHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCK 612

Query: 658  DVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVR 717
            D++EC+TPGICMNG C+N++GS+RC+C PGLAVG+DGRVCVDTHMRSTCYGG K+G C++
Sbjct: 613  DINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIK 672

Query: 718  PFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPD 777
            P  GAVTKSECCCA+ +Y FGEPCQPCPA+NSAE+  LCSSG G+T  G DINECALDPD
Sbjct: 673  PLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPD 732

Query: 778  ICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTC 837
            IC NGICENLRG+Y+C CNSGYE D++G+NC+DI+EC++N LLCDNG CRNTPGS+ CTC
Sbjct: 733  ICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTC 792

Query: 838  PPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGT 897
            P G++++ + +TCEDI+ECES+PC+NG C+N+ GSF CECS  S L  T  ICI+++KGT
Sbjct: 793  PKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGT 852

Query: 898  CWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVN 957
            CW  + D RCE+NINGATLKS+CC++LGAAWGSPC  C++D  C +G +RIKG  CED++
Sbjct: 853  CWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDID 912

Query: 958  ECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVP 1017
            ECEVFPGVC NG CVN++GSF C+CP G+TLD TGR+CLDIR+E C+L+++++EC  P+ 
Sbjct: 913  ECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIA 972

Query: 1018 GKFRMDACCCAVGAAWGTE-CEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINE 1076
            G+ RMDACCC+VGAAWGTE CEECP   T EYE LCPRG GFA + ++  G+PF+KDINE
Sbjct: 973  GRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATK-EITNGKPFFKDINE 1031

Query: 1077 CKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPG 1136
            CK  P +CT+GKCRNTIGSFKCRC+SGFALD EERNCTDIDECRISPDLCG G CVNTPG
Sbjct: 1032 CKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPG 1091

Query: 1137 SFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSRE 1196
             FEC+C EGYESGFMMMKNCMDIDEC+R+PLLCRGG C NTEGS++C+CP GH+LSP+  
Sbjct: 1092 DFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNIS 1151

Query: 1197 DCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQ 1256
             C+DINEC LS +LC NG+CVN+IG YQC+CNPGY +TPDR  C DIDEC IMNGGC+T 
Sbjct: 1152 ACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETF 1211

Query: 1257 CTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMA 1316
            CTNSEGSYECSC  G+ALMPD RSC DIDECE+NP+ICDGGQCTNIPGEYRCLCYDGFMA
Sbjct: 1212 CTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMA 1271

Query: 1317 SMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAH 1376
            S DMKTC+DVNECDLN NIC+ G CENTKGSFICHC +GYS KKG TGCTD++ECEIGAH
Sbjct: 1272 SEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAH 1331

Query: 1377 NCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCAC 1436
            NC  HA C N  GSFKCSC  GWIG+GIKC DLDECSNGTH CS +A C NT GSYRC C
Sbjct: 1332 NCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLC 1391

Query: 1437 SEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECS 1496
             EG+TGDGFTC+D+DEC+EN+NLC NGQCLN PG YRCEC+MGF P++D ++C+DIDECS
Sbjct: 1392 KEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECS 1451

Query: 1497 FQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYEC 1556
              NICVFGTC+NLPG+F C C+ GYELDR+GGNCTD++EC DP  C++G CVNTPG Y C
Sbjct: 1452 LPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYIC 1511

Query: 1557 NCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGD-GSLSCNTEIGVGVSRSSCCCSLGKAWG 1615
            +CPPDF+LNPT VGCVD R GNCYL   PRGD G  +C+ EIGVGVS++SCCCSLGKAWG
Sbjct: 1512 DCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWG 1571

Query: 1616 NPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQC 1675
             PCE CP VN++EY  LCPGGEGFRPNPIT+ILEDIDECQELPGLCQGG CINTFGSFQC
Sbjct: 1572 TPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQC 1631

Query: 1676 ECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDM 1735
             CP GYYL+EDTR+C+D++EC   PG+CGPGTCYNT+GNYTCICPP+YMQVNGG+NCMDM
Sbjct: 1632 RCPTGYYLNEDTRVCDDVNECET-PGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDM 1690

Query: 1736 RKSFCYRSY--NGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGN 1793
            R+S CYR+Y  +  TC+ EL FN+TK+MCCC+YN+G+AWNKPCE CP P T +F T+CG+
Sbjct: 1691 RRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGS 1750

Query: 1794 I-PGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDID 1852
              PGF  DI+TG  VDIDEC+EIPG+C NGVCIN +GSFRCECP GF YND LLVCEDID
Sbjct: 1751 QRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDID 1810

Query: 1853 ECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQ 1912
            EC NG  +CQRNA+CIN+ GSYRC+C  G++ +  G C DRNEC EIPN+CSHG C+D  
Sbjct: 1811 ECQNGP-VCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTV 1869

Query: 1913 GSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCL 1972
            GS+ C+CH GFK + DQTMC+D++ECER  CGNGTC+NT+GS+NC C  GF L+HNNDC+
Sbjct: 1870 GSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCI 1929

Query: 1973 DIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTC 2032
            D+DEC+S  G +CRNG+C N +GSF+C CNEGYE+ PDG+ C+D NEC+  P  C+PGTC
Sbjct: 1930 DVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTC 1989

Query: 2033 QNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDN 2092
            QNL+GS+RCICPPGY +++E C DI+EC E+P IC  G+C+NT G F+CLCP GF LS +
Sbjct: 1990 QNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSS 2049

Query: 2093 GRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQ 2152
            GRRC D R S+C+  FE GKCS PK+ N +K +CCC+ + GEGWGDPCELCP + + AF+
Sbjct: 2050 GRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCA-LKGEGWGDPCELCPTEPDEAFR 2108

Query: 2153 DLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCV 2212
             +CPYG G +    D+  D++EC E P +C +GQCINTDGS+RCECP GY L   G  CV
Sbjct: 2109 QICPYGSGIIVGPDDSAVDMDECKE-PDVCKHGQCINTDGSYRCECPFGYIL--AGNECV 2165

Query: 2213 DTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTF 2272
            DTDECS+GNPCGNGTC NVIG FEC C EGFEPGPMM CEDINECAQNPLLCAFRC+NT+
Sbjct: 2166 DTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTY 2225

Query: 2273 GSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPD 2332
            GSYEC CP+GY LRED++MCKD DEC EG HDC  + M CKNLIGT+MCIC PG  RRPD
Sbjct: 2226 GSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPD 2285

Query: 2333 GEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQ 2392
            GEGCVDENEC+TKPGICENGRC+N  GSY CECN+GF +S +  ECLDNR+G CF EVLQ
Sbjct: 2286 GEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQ 2345

Query: 2393 TICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDE 2452
             +CQ+ SS+RN VTKSECCCDGGRGWG  CE+CP  GT  +KK+CPHG G+ T+G DIDE
Sbjct: 2346 NMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDE 2405

Query: 2453 CKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGS 2512
            CKV+ ++C NG+C+N  GS+ C CK GYT DI+GTSC+DL+EC+Q+PKPCN+ICKNTEGS
Sbjct: 2406 CKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGS 2465

Query: 2513 YQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDN 2572
            YQCSCP+GY+LQEDG++CKDLDEC TKQHNCQFLCVNT+GGFTCKCPPGFTQHHT+CIDN
Sbjct: 2466 YQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDN 2525

Query: 2573 NECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNIL 2632
            NEC S  +LCG+KGICQNTPGSF+CECQRGFSLD TG +CEDVDEC+GNHRCQHGCQNI+
Sbjct: 2526 NECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQNII 2585

Query: 2633 GGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSA 2692
            GGYRC CPQGY+QHYQWNQCVDENEC + + CG ASC+NTLGSYKC CP+GF ++QFS  
Sbjct: 2586 GGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGG 2645

Query: 2693 CHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVD 2752
            C D+NEC S++ PC+YGCSNTEGGYLCGCPPGY+R+GQGHCVSGMG  +G      +   
Sbjct: 2646 CQDINECGSAQAPCSYGCSNTEGGYLCGCPPGYFRIGQGHCVSGMGMGRGNPEPPVSGEM 2705

Query: 2753 EENALSPEACYECKINGYSKKDSRQKRSIHEPDPTAVE-------QISLESVDMDSPVNM 2805
            ++N+LSPEACYECKINGY K+  R++RS +E D + +E        +SL S D++     
Sbjct: 2706 DDNSLSPEACYECKINGYPKR-GRKRRSTNETDASNIEDQSETEANVSLASWDVEKTAIF 2764

Query: 2806 KFNLSHLGSKEHILELRPAIQPLNNHIRYVISQGNDDSVFRIHQRNGLSYLHTAKKKLMP 2865
             FN+SH+ +K  ILEL PA+  L NH RY+I  GN+D  F+I+Q+ G+SYLH  KKK + 
Sbjct: 2765 AFNISHVSNKVRILELLPALTTLTNHNRYLIESGNEDGFFKINQKEGISYLHFTKKKPVA 2824

Query: 2866 GTYTLEITSIPLYKKKELKKLEESNEDDYLLGELGEALRMRLQIQLY 2912
            GTY+L+I+S PLYKKKEL +LE+  + DYL GELG+ L+M++Q+ L+
Sbjct: 2825 GTYSLQISSTPLYKKKELNQLEDKYDKDYLSGELGDNLKMKIQVLLH 2871



 Score = 1061 bits (2744), Expect = 0.0
 Identities = 746/2395 (31%), Positives = 1040/2395 (43%), Gaps = 475/2395 (19%)

Query: 32   PPPPKPPRPQPP---------PQQVRSATAGSEGGFLAPEYREEGAAVASRVR-----RR 77
            PP P+ P P+PP         P +V      ++   L     + G  + +         +
Sbjct: 420  PPGPQIPVPRPPVEYLYPSREPPRVLPVNV-TDYCQLVRYLCQNGRCIPTPGSCRCECNK 478

Query: 78   GQQDVLRGPNV--------------CGSRFHSYCC---PGWKTLPGGNQC--IVPICRNS 118
            G Q  LRG  +              C +   SY C    G+++     +C  I    +N 
Sbjct: 479  GFQLDLRGECIDVDECEKNPCAGGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNG 538

Query: 119  --CGDGFCSRPN---MCTCSSGQISSTCGS--KSIQQCSVR--CMNGGTCADD---HCQC 166
              C +G C   +    C C++G   +  G   + + +CS+R  C+NG    +D    C C
Sbjct: 539  RICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCIC 598

Query: 167  QKGY----IGTYCGQ-PVCEN-GCQNGGRCI---GPNRCAC----VYGFTGPQCERDYRT 213
            + G+     G YC     CE  G    GRC+   G  RC C      G  G  C   +  
Sbjct: 599  KPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMR 658

Query: 214  GPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQP-----CRRGFIPN 268
              C+       C   L G V     CCA+   A+G PC+ CPAQ        C  G  P 
Sbjct: 659  STCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSG--PG 716

Query: 269  IRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGI 328
            + T A  D++EC   P IC  G C N  G+++C C +G++   T + C DI+EC +   +
Sbjct: 717  M-TSAGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLL 775

Query: 329  CETGECSNTVGSYFCVCPRGYVTSTD---------------------------------- 354
            C+ G+C NT GS+ C CP+G++   D                                  
Sbjct: 776  CDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSSE 835

Query: 355  ------GSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIG-TIPEACPV 407
                   + CI+   G C+  +++GRC   + G   K QCC   G  WG   T+ +  P+
Sbjct: 836  STLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPI 895

Query: 408  RGSEEYRRL----CMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPG 463
             G + Y R+    C D       PG                  NG      G+     P 
Sbjct: 896  CG-KGYSRIKGTQCEDIDECEVFPGVC---------------KNGLCVNTRGSFKCQCPS 939

Query: 464  GNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDIC--KHHANLCLNGRCIPTVSSYR--- 518
            G                     TG   L+  ++ C  ++    C     +P    +R   
Sbjct: 940  GMTLD----------------ATGRICLDIRLETCFLRYEDEEC----TLPIAGRHRMDA 979

Query: 519  CECNMGYKQDANGDCIDVDECTSNPCTNGD-----CVNTPGSYYCKCHAGFQRTPTKQAC 573
            C C++       G     +EC   P  N       C   PG       A  + T  K   
Sbjct: 980  CCCSV-------GAAWGTEECEECPMRNTPEYEELCPRGPG------FATKEITNGKPFF 1026

Query: 574  IDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDEC-TTTNMCLNGMC 632
             DI+EC     LC +G+C NT GSF+C C++GF L ++ +NC D DEC  + ++C  G C
Sbjct: 1027 KDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQC 1086

Query: 633  INEDGSFKCIC----KPGFVLAPNGRYCTDVDECQ-TPGICMNGHCINSEGSFRCDCPPG 687
            +N  G F+C C    + GF++  N   C D+DECQ  P +C  G C N+EGS+RC+CPPG
Sbjct: 1087 VNTPGDFECKCDEGYESGFMMMKN---CMDIDECQRDPLLCRGGVCHNTEGSYRCECPPG 1143

Query: 688  LAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCC-----ANPDYGFGEPCQ 742
              +  +   C+D +           G CV      + K +C C     + PD  F     
Sbjct: 1144 HQLSPNISACIDINECELSAHLCPNGRCV----NLIGKYQCACNPGYHSTPDRLFCVDID 1199

Query: 743  PCPAKN----------SAEFHGLCSSGVGITVDGR---DINECALDPDICANGICENLRG 789
             C   N             +   C  G  +  D R   DI+EC  +P+IC  G C N+ G
Sbjct: 1200 ECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPG 1259

Query: 790  SYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETET 849
             YRC C  G+      + C+D++EC +N  +C +G C NT GS+ C C  GY  +     
Sbjct: 1260 EYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTG 1319

Query: 850  CEDINECE---SNPCVNGACRNNLGSFNCECSPG-------------------------- 880
            C DINECE    N   +  C N  GSF C CSPG                          
Sbjct: 1320 CTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHAD 1379

Query: 881  --SKLSSTGLICIDSLKGTCWLNIQDSRCEVNI----NGATLKS----ECCATLG---AA 927
              + + S   +C +   G  +       C  N+    NG  L +     C   +G   +A
Sbjct: 1380 CKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSA 1439

Query: 928  WGSPCE---RCELDTACP-------RGLARIK----------GVTCEDVNECEVFPGVCP 967
             G  CE    C L   C         GL R +          G  C DVNEC + P  C 
Sbjct: 1440 DGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNEC-LDPTTCI 1498

Query: 968  NGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYL----KWDEDE--CIHPVPGKFR 1021
            +G CVN+ GS+ C+CP    L+ T   C+D R   CYL    + D  +  C + +     
Sbjct: 1499 SGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVS 1558

Query: 1022 MDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFP 1081
              +CCC++G AWGT CE CP   T EY+ LCP G GF  R + +T     +DI+EC+  P
Sbjct: 1559 KASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGF--RPNPIT--VILEDIDECQELP 1614

Query: 1082 GMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECE 1141
            G+C  GKC NT GSF+CRC +G+ L+ + R C D++EC  +P +CG G C NT G++ C 
Sbjct: 1615 GLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECE-TPGICGPGTCYNTVGNYTCI 1673

Query: 1142 CFEGYESGFMMMKNCMDIDE--CERN----PLLCRGGTCVN-TEGSFQCDCPLGHELSPS 1194
            C   Y        NCMD+    C RN       C G    N T+    C   +G   +  
Sbjct: 1674 CPPDYMQ-VNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKP 1732

Query: 1195 REDC----------------------------VDINECSLSDNLCRNGKCVNMIGTYQCS 1226
             E C                            VDI+EC     +C NG C+NM+G+++C 
Sbjct: 1733 CEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCE 1792

Query: 1227 CNPGYQATPDRQGCTDIDECMIMNGGC---DTQCTNSEGSYECSCSEGYALMPDGRSCAD 1283
            C  G+        C DIDEC   NG     + +C N+ GSY C C  GY     G+ C D
Sbjct: 1793 CPVGFFYNDKLLVCEDIDEC--QNGPVCQRNAECINTAGSYRCDCKPGYRFTSTGQ-CND 1849

Query: 1284 IDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECEN 1343
             +EC+  P+IC  GQC +  G + CLC+ GF  + D   C+D+NEC+ ++  C  G C N
Sbjct: 1850 RNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDA--CGNGTCRN 1907

Query: 1344 TKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW--IG 1401
            T GSF C C  G+ +      C DVDEC  G  N   +  C+N  GSF+C C EG+    
Sbjct: 1908 TIGSFNCRCNHGF-ILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAP 1966

Query: 1402 NGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCE 1461
            +G  C+D++EC     +C+    C N  GSYRC C  G++     C D+DEC E   +C 
Sbjct: 1967 DGRTCVDINECLLEPRKCA-PGTCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICA 2025

Query: 1462 NGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFH----CIC 1517
             G C N  G+++C C  GF+ +S  R CQD+           G C++     H    C C
Sbjct: 2026 LGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCC 2085

Query: 1518 -------DDGYELDRT--------------------GGNCTDIDECADPINCVNGLCVNT 1550
                    D  EL  T                      +  D+DEC +P  C +G C+NT
Sbjct: 2086 ALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINT 2145

Query: 1551 PGRYECNCPPDFQLNPTGVGCVDN---RVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCC 1607
             G Y C CP  + L   G  CVD     VGN      P G+G  +C   IG       C 
Sbjct: 2146 DGSYRCECPFGYIL--AGNECVDTDECSVGN------PCGNG--TCKNVIG----GFECT 2191

Query: 1608 CSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCI 1667
            C                            EGF P P+ +  EDI+EC + P LC    C+
Sbjct: 2192 CE---------------------------EGFEPGPM-MTCEDINECAQNPLLC-AFRCV 2222

Query: 1668 NTFGSFQCECPQGYYLSEDTRICEDID--------------------------------- 1694
            NT+GS++C+CP GY L ED R+C+D D                                 
Sbjct: 2223 NTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQR 2282

Query: 1695 -----------ECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRS 1743
                       EC   PG+C  G C NT G+YTC C   +        C+D R+ +C+  
Sbjct: 2283 RPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTE 2342

Query: 1744 YNGTTCE----NELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTF 1799
                 C+    N  P  VTK  CCC  + G+ W   CE CP  GT  FK +C +  GF  
Sbjct: 2343 VLQNMCQIGSSNRNP--VTKSECCC--DGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMT 2398

Query: 1800 DIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDN 1859
            +       DIDECK I  +C NG C+N  GS+ C C TG++ +     C D++EC+    
Sbjct: 2399 N-----GADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPK 2453

Query: 1860 LCQRNADCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCI 1918
             C  N  C N+ GSY+C C  G+ L  +G +C D +EC    + C   LCV+  G + C 
Sbjct: 2454 PC--NFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQF-LCVNTIGGFTCK 2510

Query: 1919 CHNGFKASQDQTMCMDVDEC--ERHPCGN-GTCKNTVGSYNCLCYPGFELTH-NNDCLDI 1974
            C  GF  +Q  T C+D +EC  + + CG+ G C+NT GS+ C C  GF L    + C D+
Sbjct: 2511 CPPGF--TQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDV 2568

Query: 1975 DECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQN 2034
            DEC       C++G C N IG ++C C +GY        C+D NEC++    C   +C N
Sbjct: 2569 DECEG--NHRCQHG-CQNIIGGYRCSCPQGYLQHYQWNQCVDENECLS-AHICGGASCHN 2624

Query: 2035 LEGSFRCICPPG--YEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGF 2087
              GS++C+CP G  YE  S  C DINEC      C +G C+NT GG+ C CPPG+
Sbjct: 2625 TLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYG-CSNTEGGYLCGCPPGY 2678


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score = 4452 bits (11546), Expect = 0.0
 Identities = 1901/2852 (66%), Positives = 2267/2852 (79%), Gaps = 90/2852 (3%)

Query: 68   AAVASRVRRRGQQDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRP 127
            AA   RVRRRG   +L+GPNVCGSRFH+YCCPGW+T PG +QC+VPICR +CG+GFCS+P
Sbjct: 39   AAGPGRVRRRGSPGILQGPNVCGSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQP 98

Query: 128  NMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNG 187
            N+CTC+ G ++ +CG      CSV CMNGGTC    C CQKGY GT CGQP+C+ GC NG
Sbjct: 99   NLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNG 158

Query: 188  GRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAW 247
            GRCIGPNRCACVYGF GPQCERDYRTGPCF QV  + CQ QLTG+VCTK LCCAT+GRAW
Sbjct: 159  GRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAW 218

Query: 248  GHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGH 307
            G PCE+CPAQP PCRRGFIPNI TGA                                  
Sbjct: 219  GLPCELCPAQPHPCRRGFIPNIHTGA---------------------------------- 244

Query: 308  KQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCF 367
                    C+D+DEC  +PG+C+ G C N VGS+ C CP G+  S   + C D R G CF
Sbjct: 245  --------CQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACF 296

Query: 368  SGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIP 427
            S L  GRCA +L G  T+ QCCC+ GRCW  G +PE CP RGS E+++LC   LP+  +P
Sbjct: 297  SVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPL--LP 354

Query: 428  GSAGSRPG--GTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPII 485
            G  G  PG  G G NG  P        P G+    IP     S G G + +G        
Sbjct: 355  GHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIP-----SLGPGNSNIGTA------ 403

Query: 486  TGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCT 545
                 LNQTIDIC+H  NLCLNGRC+PT SSYRCECN+GY QD  G+CIDVDECTS+PC 
Sbjct: 404  ----TLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCH 459

Query: 546  NGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAG 605
            +GDCVN PG+Y+C+C+ GFQ TPT+QAC+D+DECI +G LC  GRCVNT+GSFQC+CNAG
Sbjct: 460  HGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAG 519

Query: 606  FELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTP 665
            FEL+ DGKNCVDH+EC T+ MC+NG+C+NEDGSF C+CKPGF+LAP G YC D+DECQTP
Sbjct: 520  FELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTP 579

Query: 666  GICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTK 725
            GIC+NGHC N+EGSFRC C  GLAVG DGRVCVDTH+RSTCYG I+KG C RPFPG VTK
Sbjct: 580  GICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTK 639

Query: 726  SECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICE 785
            SECCCANPD+GFGEPCQ CPAK+SAEF  LCSSG+GIT DGRDINECALDP++CANG+CE
Sbjct: 640  SECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCE 699

Query: 786  NLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 845
            NLRGSYRC CN GYE  ASG++C D+DEC +N LLCDNG C+N+PGSYSC+CPPG+ F  
Sbjct: 700  NLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQ 759

Query: 846  ETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDS 905
            +TE C+D++EC S+PCV+G CRN  GS+ C+C PGS+L  +G  C+DS KGTCWL IQ+S
Sbjct: 760  DTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQES 819

Query: 906  RCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGV 965
            RCEVN+ GA+L+SECCATLGAAWGSPCERCE+D AC RG AR+ GVTC+DVNECE FPGV
Sbjct: 820  RCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGV 879

Query: 966  CPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDAC 1025
            CPNGRCVN+ GSF CECPEGL LD +GR+C+D+R+E C+L+WDEDEC   +PGK+RMD C
Sbjct: 880  CPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVC 939

Query: 1026 CCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCT 1085
            CC++GA WG ECE CP P + E+ +LCPRG GFA+R D L+GRPFYKD+NECK FPG+CT
Sbjct: 940  CCSIGAVWGVECEACPDPESLEFASLCPRGLGFASR-DFLSGRPFYKDVNECKVFPGLCT 998

Query: 1086 YGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEG 1145
            +G CRNT+GSF C C  GFALD +ERNCTDIDECRISPDLCG G CVNTPGSFECECF G
Sbjct: 999  HGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPG 1058

Query: 1146 YESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECS 1205
            YESGFM+MKNCMD+DEC R+PLLCRGGTC NT+GS++C CP GHEL+     C DI+ECS
Sbjct: 1059 YESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECS 1118

Query: 1206 LSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYE 1265
            LSD LC +G+CVN+IG +QCSC+ G+Q+TPDRQGC DI+EC + NGGCD  C N+EGSY 
Sbjct: 1119 LSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYR 1178

Query: 1266 CSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCID 1325
            CSC +GY+LMPDGR+CAD+DECE NP +CD G CTN+PG +RCLCYDGFMA+ DM+TC+D
Sbjct: 1179 CSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVD 1238

Query: 1326 VNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCL 1385
            V+ECDLN +IC+ G+CENTKGSF+CHCQLGY V+KG TGC+DVDECE+G HNCD HASCL
Sbjct: 1239 VDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCL 1298

Query: 1386 NIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGF 1445
            NIPGSF C C  GW+G+G +C DLDEC +  H+CS    C+N PGSYRC C +GF GDGF
Sbjct: 1299 NIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGF 1358

Query: 1446 TCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGT 1505
             C D DECAEN++LC+NGQCLN PG YRCECEMGF P  D R+CQD+DEC+  N+C FG+
Sbjct: 1359 FCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGS 1418

Query: 1506 CNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLN 1565
            C NLPGMF CIC+ GYELDR GGNCTDI+ECADP+NC+NG+C+NTPG Y C+CP DF+LN
Sbjct: 1419 CENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELN 1478

Query: 1566 PTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN 1625
            P+GVGCVD R GNC+L+   RGD  +SC+ EIGVGV+R+SCCCSLG+AWGNPCE CP  N
Sbjct: 1479 PSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMAN 1538

Query: 1626 STEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSE 1685
            +TEY TLCPGGEGF+PN IT+ILEDIDECQELPGLCQGG+C+NTFGSFQCECP GY+LSE
Sbjct: 1539 TTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSE 1598

Query: 1686 DTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYN 1745
             TRICEDIDEC  H G+CGPGTCYNTLGNYTC+CP EY+QVNGG+NCMDMRKS C+R YN
Sbjct: 1599 HTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYN 1658

Query: 1746 GTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGN-IPGFTFDIHTG 1804
            G TC+NEL FNVT++MCCC+YN+G+AWN+PCE CPTP + D++ +CGN  PGF  DIHTG
Sbjct: 1659 G-TCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTG 1717

Query: 1805 KAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRN 1864
            K +DIDEC EIP ICANG+CINQIGSFRCECP GF+YN +LL CED+DEC + ++ CQ+N
Sbjct: 1718 KPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQN 1777

Query: 1865 ADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFK 1924
            ADCIN PGSYRC+C  G+KLSP GACV RNEC EIPNVCSHG C+D +GSY C+CH GF+
Sbjct: 1778 ADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQ 1837

Query: 1925 ASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQV 1984
            AS DQT+CMD+DEC+R PCGNGTCKN +GSYNCLC+PGF +THN DC+D DEC++  GQV
Sbjct: 1838 ASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQV 1897

Query: 1985 CRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICP 2044
            CR G C N  GSF CLC +G+ELT DGKNC+DTNEC++L G+C PGTCQNLEGSFRCICP
Sbjct: 1898 CRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICP 1957

Query: 2045 PGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFC 2104
            PG++V+S++CIDI+EC E+PN+CLFG+CTN+PG FQCLCPPGFVLSDNG RCFDTRQSFC
Sbjct: 1958 PGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFC 2017

Query: 2105 FTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPS 2164
            FT FE GKCSVPKAFNTTK +CCCSK PGEGWGDPCELCP++   AFQ+LCP+GHG VP 
Sbjct: 2018 FTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPG 2077

Query: 2165 LHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCG 2224
              D+REDVNEC E+PG+C+NG C+NTDGSFRCECP GY+LD+TG+ CVDTDECS+G+PCG
Sbjct: 2078 PDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCG 2137

Query: 2225 NGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYA 2284
             GTCTNVIG FEC C +GFEPG MM CEDI+EC+ NPLLCAFRC NT GSY CTCP GY 
Sbjct: 2138 QGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYT 2197

Query: 2285 LREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRP-DGEGCVDENECR 2343
            LRED  MC+D+DECA+G  DC +RGM CKNLIGTF C+CPPGM   P  GEGC D+NEC 
Sbjct: 2198 LREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECH 2257

Query: 2344 TKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRN 2403
             +P +C NGRCVN  GS+RC+C+EGFQ S + TEC D RQG CFAEVLQT+C+  SSS  
Sbjct: 2258 AQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSE 2317

Query: 2404 LVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNG 2463
             VT++ECCC GGRGWG +CELCPLPGT+ Y+K+CPHG GYT +GRD+DEC+++ +LC +G
Sbjct: 2318 AVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHG 2377

Query: 2464 QCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVL 2523
            +CIN++GSFRC C+ GYT D + T+C+D+DECSQ PKPC ++CKNT+GS+ CSCPRGY+L
Sbjct: 2378 ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLL 2437

Query: 2524 QEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCG 2583
            +EDG+TCKDLDEC ++QHNCQFLCVNT+G FTC+CPPGFTQHH AC DN+EC +QP  CG
Sbjct: 2438 EEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCG 2497

Query: 2584 AKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGY 2643
            A G C NTPGSF CEC +GF+L ++G  CEDV+ECDG HRCQHGCQN LGGYRC CPQG+
Sbjct: 2498 AHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGF 2557

Query: 2644 IQHYQWNQCVDENECS-NPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSS 2702
             QH QW QCVDENEC+ +P  CGSASC NTLG ++C CPSGF FDQ    C +V+EC+  
Sbjct: 2558 TQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGR 2617

Query: 2703 KNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEAC 2762
            + PC+Y C+NT GG+LCGCP GY+R GQGHCVSG+GF+ G     DT  D+E  LS EAC
Sbjct: 2618 RGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ---DTP-DKEELLSSEAC 2673

Query: 2763 YECKINGYSKKDSRQKRSIHEPDPTAVEQISLESVDMDSPVNMKFNLSHLGSKEHILELR 2822
            YECKING S +D R +RS H        Q++L ++D ++ + +  NLSHLG  E ILELR
Sbjct: 2674 YECKINGLSPRD-RPRRSAHRD-----HQVNLATLDSEALLTLGLNLSHLGRAERILELR 2727

Query: 2823 PAIQPLNNHIRYVISQGNDDSVFRIHQRNGLSYLHTAKKKLMPGTYTLEITSI---PLYK 2879
            PA++ L   IRYVI +GN+   FR+H   G+S L   +++  PGTY LE+ S    P   
Sbjct: 2728 PALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSSLQLGRRRPGPGTYRLEVVSHMAGPWGV 2787

Query: 2880 KKELKKLEESNEDDYLLGELGEALRMRLQIQL 2911
            + E +            G  G+ALR+++Q+QL
Sbjct: 2788 QPEGQP-----------GPWGQALRLKVQLQL 2808


>gi|110347437 latent transforming growth factor beta binding protein 4
            isoform c [Homo sapiens]
          Length = 1557

 Score =  524 bits (1350), Expect = e-148
 Identities = 369/1186 (31%), Positives = 490/1186 (41%), Gaps = 172/1186 (14%)

Query: 706  CYGGIKKGVCVRPFPGAVTKSECCCANPDYGFG-EPCQPCPAK--NSAEFH---GLCSSG 759
            C+  ++ G C  P PG  T+ E CC      +G   CQ C  +  NS       G C +G
Sbjct: 222  CFRELRGGECASPLPGLRTQ-EVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTG 280

Query: 760  VGITVDG--RDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVN 817
                V+G   D++ECA     C +G C N RG Y C C  G+  D+S  +C  I + +++
Sbjct: 281  FE-RVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVIS 336

Query: 818  RLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFN-CE 876
                  G C        C+ P       +   C  + +     C       + G    C 
Sbjct: 337  EA---KGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICP 393

Query: 877  CSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCE 936
              PG   S++     D    T  L  +  R  ++    TL +    + G       E   
Sbjct: 394  AGPGYHYSAS-----DLRYNTRPLGQEPPRVSLS-QPRTLPATSRPSAGFLPTHRLEPRP 447

Query: 937  LDTACPRG-----LARIKGVTCEDVNE-------CEVFPGVCPNGRCVNSKGSFHCECPE 984
                 PR      L  I   T  ++ E       C+  P VC  GRC++    + C C  
Sbjct: 448  EPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDS 507

Query: 985  GLTLDGTGRVCLDIRMEQCYLKWDEDEC-----------IHPVPGKFRMDACCCAVGAAW 1033
            G  L   G  C+D+           DEC               PG FR   C C  G   
Sbjct: 508  GFRLSPQGTRCIDV-----------DECRRVPPPCAPGRCENSPGSFR---CVCGPGFRA 553

Query: 1034 GTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTI 1093
            G    EC                                D++EC   P  C  G+C NT 
Sbjct: 554  GPRAAEC-------------------------------LDVDECHRVPPPCDLGRCENTP 582

Query: 1094 GSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMM 1153
            GSF C C +G+       +C D+DEC  SP LCG G C N PGSF C C  G+       
Sbjct: 583  GSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEE 642

Query: 1154 KNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRN 1213
                D+DEC + P  C  G C NT GSF C CP G         C D++EC+ S   C  
Sbjct: 643  ----DVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTY 698

Query: 1214 GKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYEC-SCSEGY 1272
            G+C N  G++QC C  G+Q       C D+DEC         +C NS GS++C +C  G+
Sbjct: 699  GRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGH 758

Query: 1273 ALMPDGRSCADIDECENNPDICDG-GQCTNIPGEYRCLCYDGFMASMDMK-TCIDVNECD 1330
             L   GR C D+DEC +    C   G CTN  G +RC C  G+ A       C DVNEC 
Sbjct: 759  HLHR-GR-CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC- 815

Query: 1331 LNSNICM-FGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPG 1389
            L  + C   GEC NT GSF C C  GY        C DVDEC     +      C N  G
Sbjct: 816  LEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS--EEDLCQSGICTNTDG 873

Query: 1390 SFKCSCREGWIGNG--IKCIDLDECSNGTHQCSINAQCVNTPGSYRCA--CSEGF-TGDG 1444
            SF+C C  G         C+D+DEC         + +C N+PGSYRC   C  G+  G  
Sbjct: 874  SFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPE 933

Query: 1445 FTCSDVDECAE-NINLCENGQCLNVPGAYRCE--CEMGFTPASDSRSCQDIDECSFQNIC 1501
             TC DVDEC E    +C   +C N PG+YRC   C+ G+ P      CQD+DEC  ++ C
Sbjct: 934  GTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFC 992

Query: 1502 -VFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPIN-CVNGLCVNTPGRYECNCP 1559
                 C NLPG F C+CD GYE  R G +C D++EC      C   LC N  G + C CP
Sbjct: 993  GAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCP 1052

Query: 1560 --PDFQLNPTGVGCVDNRVGNCYL-----------------------------KFGPRGD 1588
              P+ + +P    CV  R                                   + GP G 
Sbjct: 1053 NSPE-EFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGS 1111

Query: 1589 GSL----------SCNTEIGVGVSRSSCCCSLGKAWGNPC--ETCPPVNSTEYYTLCPGG 1636
            G            +C+  +   V+   CCC++G+ WG+ C  + CP   + EY +LCP G
Sbjct: 1112 GRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHG 1171

Query: 1637 EGF-RPNPITIILEDIDECQELPG-LCQGGNCINTFGSFQCECPQGYYLSEDTRICEDID 1694
             G+  P+    +  D+DECQ     +C+ G C+NT   + C C  GYY       C D D
Sbjct: 1172 RGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDND 1231

Query: 1695 ECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNC-------MDMRKSFCYRSYNG- 1746
            EC      C  G C NT+G+Y C C P  +       C       +D     C++     
Sbjct: 1232 ECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGAD 1291

Query: 1747 TTCEN-ELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC 1791
              C +  L    T   CCC Y  G+AW   C  CP   + DF+ +C
Sbjct: 1292 LVCSHPRLDRQATYTECCCLY--GEAWGMDCALCPAQDSDDFEALC 1335



 Score =  491 bits (1264), Expect = e-138
 Identities = 338/1034 (32%), Positives = 471/1034 (45%), Gaps = 139/1034 (13%)

Query: 1677 CPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMR 1736
            CP G+     +  CED+DEC A  G C  G C NT G YTC+CP  ++  +   +C+   
Sbjct: 277  CPTGFERVNGS--CEDVDEC-ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 333

Query: 1737 -----KSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC 1791
                 K  C+R      C   +  N+TK++CCC+  VGKAW + C+ CP  G+  F+ IC
Sbjct: 334  VISEAKGPCFRVLRDGGCSLPILRNITKQICCCS-RVGKAWGRGCQLCPPFGSEGFREIC 392

Query: 1792 GNIPGFTFDIHTGK-----------AVDIDECKEIPGIC---ANGVCINQIGSFRCECPT 1837
               PG+ +     +            V + + + +P      A  +  +++       P 
Sbjct: 393  PAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPD 452

Query: 1838 GFSYNDLLLVC------EDIDECSNGDNLCQRNAD------CINSPGSYRCECAAGFKLS 1885
                 +L L         +I E      +CQRN        CI+ P  Y C C +GF+LS
Sbjct: 453  PRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLS 512

Query: 1886 PNGA-CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECER--HP 1942
            P G  C+D +EC  +P  C+ G C +  GS++C+C  GF+A      C+DVDEC R   P
Sbjct: 513  PQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPP 572

Query: 1943 CGNGTCKNTVGSYNCLCYPGFELT-HNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLC 2001
            C  G C+NT GS+ C+C  G++   H   C D+DEC+   G +C  G C N  GSF+C+C
Sbjct: 573  CDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPG-LCGRGACKNLPGSFRCVC 631

Query: 2002 NEGYELTPDGKNCI-DTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDIN 2058
              G+     G  C  D +EC   P  C PG C N  GSF C CP G+  +     C D++
Sbjct: 632  PAGFR----GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVD 687

Query: 2059 ECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQ---------SFCFTNFE 2109
            EC   P  C +G C NT G FQC+CP GF  +  G  C D  +           C  +  
Sbjct: 688  ECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPG 747

Query: 2110 NGKC-SVPKAFNTTKAKC-----CCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVP 2163
            + +C + P   +  + +C     C S  P  G    C     + E +F+  C  G+    
Sbjct: 748  SFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCT----NTEGSFRCSCAPGYRAPS 803

Query: 2164 SLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPC 2223
                   DVNECLE      +G+C+NTDGSF C C  GY     G  C+D DECS  + C
Sbjct: 804  GRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLC 863

Query: 2224 GNGTCTNVIGSFECNCNEGFEPGP-MMNCEDINECAQ-NPLLC-AFRCMNTFGSYECT-- 2278
             +G CTN  GSFEC C  G   GP + +C D++EC +  P LC + RC N+ GSY C   
Sbjct: 864  QSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRD 923

Query: 2279 CPIGYALREDQKMCKDLDECAE-GLHDCESRGMMCKNLIGTFMC--ICPPGMARRPDGEG 2335
            C  GY     +  C D+DEC E G   C ++   C+N  G++ C   C PG    P G G
Sbjct: 924  CDPGYH-AGPEGTCDDVDECQEYGPEICGAQ--RCENTPGSYRCTPACDPGYQPTPGG-G 979

Query: 2336 CVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTIC 2395
            C D +ECR +     +  C N+ GS++C C++G++ +  G  C+D  +     E LQ +C
Sbjct: 980  CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNE----CETLQGVC 1035

Query: 2396 QMASSSRNLVTKSECCCDG---------GRGWGHQCELCPLPGT---AQYKKICPHGP-- 2441
              A+   N+     C C           GR    +      PG+   A    + P  P  
Sbjct: 1036 G-AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPP 1094

Query: 2442 ------------GYTTDGRDIDEC---KVMPNLCTNGQCINTMGSFRCFCKVGYTTDISG 2486
                        G    GR   EC      P+ C N    N      C C VG   +  G
Sbjct: 1095 PPLPRRPSTPRQGPVGSGR--RECYFDTAAPDACDNILARNVTWQ-ECCCTVG---EGWG 1148

Query: 2487 TSCIDLDECSQSPKPCNYICKNTE-GSYQCSCP--RGYVLQE-DGKTCKDLDECQT-KQH 2541
            + C       Q        C  TE   YQ  CP  RGY+    D    +D+DECQ  +  
Sbjct: 1149 SGC----RIQQ--------CPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQ 1196

Query: 2542 NCQF-LCVNTLGGFTCKCPPGFTQH--HTACIDNNECGSQPSLCGAKGICQNTPGSFSCE 2598
             C+  +CVNT  G++C C  G+  H     CIDN+EC  +   C   G C NT GS+ C 
Sbjct: 1197 VCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEG-GRCVNTVGSYHCT 1255

Query: 2599 CQRGFSLDATGLNC 2612
            C+    LD +   C
Sbjct: 1256 CEPPLVLDGSQRRC 1269



 Score =  472 bits (1214), Expect = e-132
 Identities = 368/1217 (30%), Positives = 501/1217 (41%), Gaps = 201/1217 (16%)

Query: 1436 CSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDEC 1495
            C  G  G  +   D   C+E +    N + ++ P      C  GF   + S  C+D+DEC
Sbjct: 244  CCRG-AGLAWGVHDCQLCSERLG---NSERVSAPDG---PCPTGFERVNGS--CEDVDEC 294

Query: 1496 SFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYE 1555
            +    C  G C N  G + C+C DG+ LD +  +C         I+   G C        
Sbjct: 295  ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCIS----QHVISEAKGPCFRVLRDGG 350

Query: 1556 CNCPPDFQLNPTGVGCVDNRVGNCYLK-------FGPRGDGSLSCNTEIGVGVSRSSCC- 1607
            C+ P     N T   C  +RVG  + +       FG  G   + C    G   S S    
Sbjct: 351  CSLP--ILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREI-CPAGPGYHYSASDLRY 407

Query: 1608 -----------CSLGKAWGNPCETCPPVNSTEYYTLCPGGEGF---RPNPITIILE---- 1649
                        SL +    P  + P       + L P  E     RP P   +      
Sbjct: 408  NTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAW 467

Query: 1650 ---DIDE-------CQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAH 1699
               +I E       CQ  P +C  G CI+    + C C  G+ LS     C D+DEC   
Sbjct: 468  TGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRV 527

Query: 1700 PGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTK 1759
            P  C PG C N+ G++ C+C P +        C+D+ +  C+R                 
Sbjct: 528  PPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDE--CHR---------------VP 570

Query: 1760 RMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGIC 1819
              C    ++G+  N       TPG+  F  +C    G+    H     D+DEC + PG+C
Sbjct: 571  PPC----DLGRCEN-------TPGS--FLCVCP--AGYQAAPHGASCQDVDECTQSPGLC 615

Query: 1820 ANGVCINQIGSFRCECPTGFSYNDLLLVC-EDIDECSNGDNLCQRNADCINSPGSYRCEC 1878
              G C N  GSFRC CP GF  +     C ED+DEC+     C     C N+ GS+ C C
Sbjct: 616  GRGACKNLPGSFRCVCPAGFRGS----ACEEDVDECAQEPPPCGPGR-CDNTAGSFHCAC 670

Query: 1879 AAGFK-LSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDE 1937
             AGF+   P   C D +EC   P  C++G C + +GS+QC+C  GF+ +   + C DVDE
Sbjct: 671  PAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE 730

Query: 1938 CERH-PCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGS 1996
            CE H  C    C N+ GS+ C   P     H   C D+DECSS       +G C N  GS
Sbjct: 731  CENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGS 790

Query: 1997 FKCLCNEGYELTPDGK--NCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYE--VKSE 2052
            F+C C  GY   P G+   C D NEC+        G C N +GSF C C PGY    +  
Sbjct: 791  FRCSCAPGYR-APSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 849

Query: 2053 NCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGK 2112
            +C+D++EC E+ ++C  G CTNT G F+C+CPPG     +   C D  +       E G 
Sbjct: 850  SCLDVDECSEE-DLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDEC-----RERG- 902

Query: 2113 CSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDV 2172
               P    + +    C   PG         C +D        C  G+   P    T +DV
Sbjct: 903  ---PALCGSQR----CENSPGS------YRCVRD--------CDPGYHAGP--EGTCDDV 939

Query: 2173 NECLE-SPGICSNGQCINTDGSFRC--ECPMGYNLDYTGVRCVDTDECSIGNPCG-NGTC 2228
            +EC E  P IC   +C NT GS+RC   C  GY     G  C D DEC   + CG +  C
Sbjct: 940  DECQEYGPEICGAQRCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRSFCGAHAVC 998

Query: 2229 TNVIGSFECNCNEGFEPG-PMMNCEDINECAQNPLLC-AFRCMNTFGSYECTCPIGYALR 2286
             N+ GSF+C C++G+E      +C D+NEC     +C A  C N  GS+ C CP      
Sbjct: 999  QNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCP------ 1052

Query: 2287 EDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICP-----PGMARRPDGEGCVDENE 2341
                         E       R +  +   GTF    P     P +  RP          
Sbjct: 1053 ----------NSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARP------PPPP 1096

Query: 2342 CRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSS 2401
               +P     G     +GS R EC       ++  +  DN                   +
Sbjct: 1097 LPRRPSTPRQGP----VGSGRREC----YFDTAAPDACDN-----------------ILA 1131

Query: 2402 RNLVTKSECCCDGGRGWGHQCEL--CPLPGTAQYKKICPHGPGYTTDG------RDIDEC 2453
            RN VT  ECCC  G GWG  C +  CP   TA+Y+ +CPHG GY          RD+DEC
Sbjct: 1132 RN-VTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDEC 1190

Query: 2454 KVM-PNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPC-NYICKNTEG 2511
            ++    +C +G C+NT   + C+C  GY        CID DEC+     C    C NT G
Sbjct: 1191 QLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVG 1250

Query: 2512 SYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCP---PGFTQHHTA 2568
            SY C+C    VL    + C   +E Q+   N             C  P      T     
Sbjct: 1251 SYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECC 1309

Query: 2569 CIDNNECGSQPSLCGAK 2585
            C+     G   +LC A+
Sbjct: 1310 CLYGEAWGMDCALCPAQ 1326



 Score =  458 bits (1179), Expect = e-128
 Identities = 293/923 (31%), Positives = 401/923 (43%), Gaps = 156/923 (16%)

Query: 1453 CAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECS-FQNICVFGTCNNLPG 1511
            C  N  +C  G+C++ P  Y C C+ GF  +     C D+DEC      C  G C N PG
Sbjct: 482  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 541

Query: 1512 MFHCICDDGYELDRTGGNCTDIDECAD-PINCVNGLCVNTPGRYECNCPPDFQLNPTGVG 1570
             F C+C  G+        C D+DEC   P  C  G C NTPG + C CP  +Q  P G  
Sbjct: 542  SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGAS 601

Query: 1571 CVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYY 1630
            C D  V  C    G  G G+                           C+  P      + 
Sbjct: 602  CQD--VDECTQSPGLCGRGA---------------------------CKNLPG----SFR 628

Query: 1631 TLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRIC 1690
             +CP G  FR +      ED+DEC + P  C  G C NT GSF C CP G+        C
Sbjct: 629  CVCPAG--FRGSACE---EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPC 683

Query: 1691 EDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCE 1750
            +D+DEC   P  C  G C NT G++ C+CP  +     G  C D+ +           CE
Sbjct: 684  QDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE-----------CE 732

Query: 1751 NELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDID 1810
            N L        C     V    +  C  CP+                   +H G+  D+D
Sbjct: 733  NHLA-------CPGQECVNSPGSFQCRTCPSG----------------HHLHRGRCTDVD 769

Query: 1811 ECKEIPGICA-NGVCINQIGSFRCECPTGF-SYNDLLLVCEDIDECSNGDNLCQRNADCI 1868
            EC      C  +G C N  GSFRC C  G+ + +     C D++EC  GD  C  + +C+
Sbjct: 770  ECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGD-FCFPHGECL 828

Query: 1869 NSPGSYRCECAAGFKLSPNGA-CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQ 1927
            N+ GS+ C CA G++  P GA C+D +EC E  ++C  G+C +  GS++CIC  G +A  
Sbjct: 829  NTDGSFACTCAPGYRPGPRGASCLDVDECSE-EDLCQSGICTNTDGSFECICPPGHRAGP 887

Query: 1928 DQTMCMDVDEC-ERHP--CGNGTCKNTVGSYNCL--CYPGFELTHNNDCLDIDECSSFFG 1982
            D   C+DVDEC ER P  CG+  C+N+ GSY C+  C PG+       C D+DEC  +  
Sbjct: 888  DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGP 947

Query: 1983 QVCRNGRCFNEIGSFKCL--CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFR 2040
            ++C   RC N  GS++C   C+ GY+ TP G  C D +EC       +   CQNL GSF+
Sbjct: 948  EICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQ 1006

Query: 2041 CICPPGYEVKSE--NCIDINECDEDPNICLFGSCTNTPGGF----------------QCL 2082
            C+C  GYE   +  +C+D+NEC+    +C    C N  G F                +C+
Sbjct: 1007 CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1066

Query: 2083 CPPGFVLSDNG---------------------RRCFDTRQS--------FCFTNFENGKC 2113
             P     +  G                     RR    RQ           F       C
Sbjct: 1067 PPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDAC 1126

Query: 2114 SVPKAFNTTKAKCCCSKMPGEGWGDPCEL--CPKDDEVAFQDLCPYGHGTVPSLHDT--R 2169
                A N T  +CCC+   GEGWG  C +  CP  +   +Q LCP+G G +    D   R
Sbjct: 1127 DNILARNVTWQECCCTV--GEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLR 1184

Query: 2170 EDVNEC-LESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNP-CGNGT 2227
             DV+EC L    +C +G C+NT   + C C  GY      + C+D DEC+   P C  G 
Sbjct: 1185 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGR 1244

Query: 2228 CTNVIGSFECNCNEGFE-PGPMMNC---------EDINECAQN---PLLCAFRCMNTFGS 2274
            C N +GS+ C C       G    C         +++  C Q     L+C+   ++   +
Sbjct: 1245 CVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQAT 1304

Query: 2275 Y-ECTCPIGYALREDQKMCKDLD 2296
            Y EC C  G A   D  +C   D
Sbjct: 1305 YTECCCLYGEAWGMDCALCPAQD 1327



 Score =  426 bits (1094), Expect = e-118
 Identities = 358/1219 (29%), Positives = 493/1219 (40%), Gaps = 250/1219 (20%)

Query: 214  GPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWG-HPCEMCPAQPQPCRRGFIPNIRTG 272
            G CF ++    C   L G+  T+ +CC   G AWG H C++C  +     R   P     
Sbjct: 220  GYCFRELRGGECASPLPGLR-TQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAP----- 273

Query: 273  ACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG 332
                                       +  CP G ++      CED+DEC+   G C+ G
Sbjct: 274  ---------------------------DGPCPTGFER--VNGSCEDVDECAT-GGRCQHG 303

Query: 333  ECSNTVGSYFCVCPRGYVTSTDGSRCIDQRT-----GMCFSGLVNGRCAQELPGRMTKMQ 387
            EC+NT G Y CVCP G++  +  S CI Q       G CF  L +G C+  +   +TK  
Sbjct: 304  ECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQI 363

Query: 388  CCCEP-GRCWGIGTIPEACPVRGSEEYRRLCMDG--------------LPMGGIPGS--- 429
            CCC   G+ WG G   + CP  GSE +R +C  G               P+G  P     
Sbjct: 364  CCCSRVGKAWGRGC--QLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSL 421

Query: 430  -------AGSRPGGTGGNGFAPSGNGNGYG-------PGGTGFIP-IPGGNGFSPGVGGA 474
                   A SRP      GF P+              PG    +P IP   G  P +  +
Sbjct: 422  SQPRTLPATSRPSA----GFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTG--PEIPES 475

Query: 475  GVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGD-C 533
            G  +G                 +C+ +  +C  GRCI   S Y C C+ G++    G  C
Sbjct: 476  GPSSG-----------------MCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRC 518

Query: 534  IDVDEC--TSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRC 591
            IDVDEC     PC  G C N+PGS+ C C  GF+  P    C+D+DEC +    C  GRC
Sbjct: 519  IDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 578

Query: 592  VNTDGSFQCICNAGFELTTDGKNCVDHDECTTT-NMCLNGMCINEDGSFKCICKPGFVLA 650
             NT GSF C+C AG++    G +C D DECT +  +C  G C N  GSF+C+C  GF   
Sbjct: 579  ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--- 635

Query: 651  PNGRYCT-DVDEC-QTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVD--------- 699
              G  C  DVDEC Q P  C  G C N+ GSF C CP G      G  C D         
Sbjct: 636  -RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPP 694

Query: 700  --THMRSTCYGGIKKGVCVRPFPGAVTKSEC-----------C----CANPDYGFGEPCQ 742
              T+ R     G  + VC   F      SEC           C    C N    F   C+
Sbjct: 695  PCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSF--QCR 752

Query: 743  PCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICA-NGICENLRGSYRCNCNSGYE- 800
             CP+ +     G C+          D++EC+     C  +G C N  GS+RC+C  GY  
Sbjct: 753  TCPSGHHLH-RGRCT----------DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRA 801

Query: 801  PDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINEC-ESN 859
            P      C D++ECL       +G C NT GS++CTC PGY       +C D++EC E +
Sbjct: 802  PSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEED 861

Query: 860  PCVNGACRNNLGSFNCECSPGSKLSSTGLICID----SLKGTCWLNIQDSRCEVNINGAT 915
             C +G C N  GSF C C PG +       C+D      +G      Q  RCE +     
Sbjct: 862  LCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ--RCENSPGSYR 919

Query: 916  LKSECCATLGAAWGSPCE----------------RCE-------LDTACPRGLARIKGVT 952
               +C     A     C+                RCE          AC  G     G  
Sbjct: 920  CVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG 979

Query: 953  CEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDEC 1012
            C+DV+EC        +  C N  GSF C C +G      GR C+D+         +E E 
Sbjct: 980  CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDV---------NECET 1030

Query: 1013 IHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPR------GAGF-------A 1059
            +  V G     A C  V  ++   C   P+    E++ +  R       AG        A
Sbjct: 1031 LQGVCGA----ALCENVEGSFLCVCPNSPE----EFDPMTGRCVPPRTSAGTFPGSQPQA 1082

Query: 1060 NRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFAL-----DMEERNCT 1114
                VL  RP    +    + P        +  +GS +  C    A      ++  RN T
Sbjct: 1083 PASPVLPARPPPPPLPRRPSTPR-------QGPVGSGRRECYFDTAAPDACDNILARNVT 1135

Query: 1115 DIDECRISPDLCGSGICVNT-PGSFE------CECFEGY--ESGFMMMKNCMDIDECER- 1164
              + C    +  GSG  +   PG+        C    GY   SG + ++   D+DEC+  
Sbjct: 1136 WQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRR--DVDECQLF 1193

Query: 1165 NPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQ 1224
               +C+ G CVNT   + C C  G+     R +C+D +EC+  +  C  G+CVN +G+Y 
Sbjct: 1194 RDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYH 1253

Query: 1225 CSCNPGYQATPDRQGCTDIDECMIMNG--------GCDTQCT----NSEGSY-ECSCSEG 1271
            C+C P       ++ C   +   + +         G D  C+    + + +Y EC C  G
Sbjct: 1254 CTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYG 1313

Query: 1272 YALMPDGRSC--ADIDECE 1288
             A   D   C   D D+ E
Sbjct: 1314 EAWGMDCALCPAQDSDDFE 1332



 Score =  424 bits (1089), Expect = e-118
 Identities = 299/929 (32%), Positives = 393/929 (42%), Gaps = 135/929 (14%)

Query: 1287 CENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKG 1346
            C+ NP +C  G+C + P  Y C C  GF  S     CIDV+EC      C  G CEN+ G
Sbjct: 482  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 541

Query: 1347 SFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIG--NGI 1404
            SF C C  G+        C DVDEC      CD+   C N PGSF C C  G+    +G 
Sbjct: 542  SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDL-GRCENTPGSFLCVCPAGYQAAPHGA 600

Query: 1405 KCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQ 1464
             C D+DEC+     C   A C N PGS+RC C  GF G      DVDECA+    C  G+
Sbjct: 601  SCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACE-EDVDECAQEPPPCGPGR 658

Query: 1465 CLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNI-CVFGTCNNLPGMFHCICDDGYEL 1523
            C N  G++ C C  GF        CQD+DEC+     C +G C N  G F C+C  G++ 
Sbjct: 659  CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 718

Query: 1524 DRTGGNCTDIDECADPINCVNGLCVNTPGRYECN-CPPDFQLNPTGVGCVDNRVGNCYLK 1582
            +  G  C D+DEC + + C    CVN+PG ++C  CP    L+     C D  V  C   
Sbjct: 719  NTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTD--VDECSSG 774

Query: 1583 FGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPN 1642
              P G      NTE         C C+ G                      P G   RP 
Sbjct: 775  APPCGPHGHCTNTE-----GSFRCSCAPGYR-------------------APSG---RPG 807

Query: 1643 PITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGV 1702
            P      D++EC E       G C+NT GSF C C  GY        C D+DEC +   +
Sbjct: 808  PCA----DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDEC-SEEDL 862

Query: 1703 CGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMC 1762
            C  G C NT G++ CICPP +       +C+D+ +           C    P      +C
Sbjct: 863  CQSGICTNTDGSFECICPPGHRAGPDLASCLDVDE-----------CRERGP-----ALC 906

Query: 1763 CCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEI-PGICAN 1821
                      ++ CE  P      ++ +    PG+      G   D+DEC+E  P IC  
Sbjct: 907  ---------GSQRCENSP----GSYRCVRDCDPGYHAGPE-GTCDDVDECQEYGPEICGA 952

Query: 1822 GVCINQIGSFRCE--CPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECA 1879
              C N  GS+RC   C  G+        C+D+DEC N  + C  +A C N PGS++C C 
Sbjct: 953  QRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNR-SFCGAHAVCQNLPGSFQCLCD 1010

Query: 1880 AGFKLSPNGA-CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNG---------------- 1922
             G++ + +G  CVD NEC  +  VC   LC +++GS+ C+C N                 
Sbjct: 1011 QGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRT 1070

Query: 1923 ----FKASQDQTMCMDVDECERHPCGNGTCKNT-----VGSYNCLCYPGFELTHNNDCLD 1973
                F  SQ Q     V      P       +T     VGS    CY  F+    + C +
Sbjct: 1071 SAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECY--FDTAAPDACDN 1128

Query: 1974 I-------DEC----SSFFGQVCRNGRC-FNEIGSFKCLCNEGYE-LTPDGKNCI--DTN 2018
            I        EC       +G  CR  +C   E   ++ LC  G   L P G   +  D +
Sbjct: 1129 ILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVD 1188

Query: 2019 ECVALPGS-CSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPNICLFGSCTNT 2075
            EC       C  G C N    + C C  GY   ++   CID +EC ++   C  G C NT
Sbjct: 1189 ECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNT 1248

Query: 2076 PGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNF-----ENGK---CSVPKA-FNTTKAKC 2126
             G + C C P  VL  + RRC          N      E G    CS P+     T  +C
Sbjct: 1249 VGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTEC 1308

Query: 2127 CCSKMPGEGWGDPCELCPKDDEVAFQDLC 2155
            CC  + GE WG  C LCP  D   F+ LC
Sbjct: 1309 CC--LYGEAWGMDCALCPAQDSDDFEALC 1335



 Score =  418 bits (1075), Expect = e-116
 Identities = 350/1212 (28%), Positives = 480/1212 (39%), Gaps = 267/1212 (22%)

Query: 171  IGTYCGQPVCENG-----CQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMC 225
            I  + G  + E+G     CQ   +  GP RC          C+  +R  P  T+      
Sbjct: 464  IPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRC----- 518

Query: 226  QGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIP 284
               +    C +       GR     CE  P   +  C  GF    R   C DVDEC  +P
Sbjct: 519  ---IDVDECRRVPPPCAPGR-----CENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVP 570

Query: 285  GICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCV 344
              C  G C NT GSF C CPAG++ +     C+D+DEC+  PG+C  G C N  GS+ CV
Sbjct: 571  PPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCV 630

Query: 345  CPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWG-IGTIPE 403
            CP G+     GS C +              CAQE P         C PGRC    G+   
Sbjct: 631  CPAGF----RGSACEED----------VDECAQEPPP--------CGPGRCDNTAGSFHC 668

Query: 404  ACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPG 463
            ACP        R    G P   +   A S P  T G      G+     P          
Sbjct: 669  ACPAG-----FRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCP---------- 713

Query: 464  GNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCE-CN 522
              GF P   G+                  + +D C++H   C    C+ +  S++C  C 
Sbjct: 714  -MGFQPNTAGSEC----------------EDVDECENHL-ACPGQECVNSPGSFQCRTCP 755

Query: 523  MGYKQDANGDCIDVDECTSN--PC-TNGDCVNTPGSYYCKCHAGFQRTPTKQ--ACIDID 577
             G+     G C DVDEC+S   PC  +G C NT GS+ C C  G+ R P+ +   C D++
Sbjct: 756  SGHHLH-RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGY-RAPSGRPGPCADVN 813

Query: 578  ECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDG 637
            EC++      +G C+NTDGSF C C  G+     G +C+D DEC+  ++C +G+C N DG
Sbjct: 814  ECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDG 873

Query: 638  SFKCICKPGFVLAPNGRYCTDVDECQT--PGICMNGHCINSEGSFRC--DCPPGLAVGMD 693
            SF+CIC PG    P+   C DVDEC+   P +C +  C NS GS+RC  DC PG   G +
Sbjct: 874  SFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPE 933

Query: 694  GRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFH 753
            G  C D                           EC    P+    + C+  P   S    
Sbjct: 934  G-TCDDV-------------------------DECQEYGPEICGAQRCENTP--GSYRCT 965

Query: 754  GLCSSGVGITVDG--RDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDI 811
              C  G   T  G  +D++EC       A+ +C+NL GS++C C+ GYE    GR+C+D+
Sbjct: 966  PACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDV 1025

Query: 812  DECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGAC---RN 868
            +EC   + +C   LC N  GS+ C CP               N  E    + G C   R 
Sbjct: 1026 NECETLQGVCGAALCENVEGSFLCVCP---------------NSPEEFDPMTGRCVPPRT 1070

Query: 869  NLGSF-----NCECSP-----------GSKLSSTGLICIDSLKGTCWLN-IQDSRCEVNI 911
            + G+F         SP             + S+     + S +  C+ +      C+  +
Sbjct: 1071 SAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNIL 1130

Query: 912  NGATLKSECCATLGAAWGSPC--------ERCELDTACPRG---LARIKGVTC-EDVNEC 959
                   ECC T+G  WGS C        E  E  + CP G   LA    ++   DV+EC
Sbjct: 1131 ARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDEC 1190

Query: 960  EVF------PGVCPN-------------------------------------GRCVNSKG 976
            ++F       GVC N                                     GRCVN+ G
Sbjct: 1191 QLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVG 1250

Query: 977  SFHCECPEGLTLDGTGRVC-------LDIRMEQCYLKWDED-ECIHP-VPGKFRMDACCC 1027
            S+HC C   L LDG+ R C       LD  +  C+ +   D  C HP +  +     CCC
Sbjct: 1251 SYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCC 1310

Query: 1028 AVGAAWGTECEECPKPGTKEYETLC----------PRGAGFA-------NRGDVLTGRPF 1070
              G AWG +C  CP   + ++E LC          PR  GF        + G    G P+
Sbjct: 1311 LYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPY 1370

Query: 1071 YKDINECKAFP-------------GMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDID 1117
              ++    A P                 YG  R  +  F+   + G      E       
Sbjct: 1371 GPELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFE---DDGGPYGESEAPAPPGP 1427

Query: 1118 ECR---ISPDLCGSGICVNTP---GSFECECFEGYESGFMMMKNCMDIDECERNPLLCRG 1171
              R    S D   S      P   GS+     E YE   +  + C  +D        C  
Sbjct: 1428 GTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEE--LEAEECGILDG-------CTN 1478

Query: 1172 GTCVNTEGSFQCDCPLGHELSPSREDCVDINEC---SLSDNLCRNGKCVNMIGTYQCSCN 1228
            G CV     F C C  G+ L  +R  CVDINEC     +  LC N +C+N  G+++C C 
Sbjct: 1479 GRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICR 1538

Query: 1229 PGYQATPDRQGC 1240
            PG+  T     C
Sbjct: 1539 PGFAPTHQPHHC 1550



 Score =  392 bits (1007), Expect = e-108
 Identities = 271/841 (32%), Positives = 363/841 (43%), Gaps = 144/841 (17%)

Query: 1983 QVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCI 2042
            QVC  GRC +    + C C+ G+ L+P G  CID +EC  +P  C+PG C+N  GSFRC+
Sbjct: 487  QVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCV 546

Query: 2043 CPPGYEV--KSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR 2100
            C PG+    ++  C+D++EC   P  C  G C NTPG F C+CP G+  + +G  C D  
Sbjct: 547  CGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVD 606

Query: 2101 QSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYG-H 2159
            +                          C++ PG      C+  P     +F+ +CP G  
Sbjct: 607  E--------------------------CTQSPGLCGRGACKNLPG----SFRCVCPAGFR 636

Query: 2160 GTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSI 2219
            G+        EDV+EC + P  C  G+C NT GSF C CP G+     G  C D DEC+ 
Sbjct: 637  GSA-----CEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 691

Query: 2220 GNP-CGNGTCTNVIGSFECNCNEGFEPGPM-MNCEDINECAQNPLLCAFR-CMNTFGSYE 2276
              P C  G C N  GSF+C C  GF+P      CED++EC +N L C  + C+N+ GS++
Sbjct: 692  SPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC-ENHLACPGQECVNSPGSFQ 750

Query: 2277 C-TCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEG 2335
            C TCP G+ L   +  C D+DEC+ G   C   G  C N  G+F C C PG  R P G  
Sbjct: 751  CRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGH-CTNTEGSFRCSCAPGY-RAPSGRP 806

Query: 2336 --CVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQT 2393
              C D NEC        +G C+N  GS+ C C  G++    G  CLD  +  C  E L  
Sbjct: 807  GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDE--CSEEDL-- 862

Query: 2394 ICQMASSSRNLVTKSECCCDGGRGWGHQCELC--------------------PLPGTAQY 2433
             CQ    + N     EC C  G   G     C                      PG+ + 
Sbjct: 863  -CQSGICT-NTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRC 920

Query: 2434 KKICPHGPGYTTDGR--DIDECKVM-PNLCTNGQCINTMGSFRCF--CKVGYTTDISGTS 2488
             + C  G     +G   D+DEC+   P +C   +C NT GS+RC   C  GY     G  
Sbjct: 921  VRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-G 979

Query: 2489 CIDLDEC-SQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNC-QFL 2546
            C D+DEC ++S    + +C+N  GS+QC C +GY    DG+ C D++EC+T Q  C   L
Sbjct: 980  CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAAL 1039

Query: 2547 CVNTLGGFTCKCPPG---FTQHHTACIDNNEC-----GSQPSLCGAKGICQNTP------ 2592
            C N  G F C CP     F      C+          GSQP    +  +    P      
Sbjct: 1040 CENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPR 1099

Query: 2593 ----------GSFSCECQRGFSLDATGLNCEDVDECDG----NHRCQHGCQNILGGYRCG 2638
                      GS   EC           +    D CD     N   Q  C  +  G+  G
Sbjct: 1100 RPSTPRQGPVGSGRRECY---------FDTAAPDACDNILARNVTWQECCCTVGEGWGSG 1150

Query: 2639 CP-------------------QGYIQ---HYQWNQCVDENECSNPNACGSASCYNTLGSY 2676
            C                    +GY+         + VDE +      C S  C NT   Y
Sbjct: 1151 CRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGY 1210

Query: 2677 KCACPSGFSFDQFSSACHDVNECSSSKNPCNYG-CSNTEGGYLCGC-PPGYYRVGQGHCV 2734
             C C +G+ +      C D +EC+  +  C  G C NT G Y C C PP      Q  CV
Sbjct: 1211 SCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1270

Query: 2735 S 2735
            S
Sbjct: 1271 S 1271



 Score =  377 bits (969), Expect = e-104
 Identities = 281/866 (32%), Positives = 378/866 (43%), Gaps = 143/866 (16%)

Query: 1896 CLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECER--HPCGNGTCKNTVG 1953
            C   P VC  G C+     Y C C +GF+ S   T C+DVDEC R   PC  G C+N+ G
Sbjct: 482  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 541

Query: 1954 SYNCLCYPGFEL-THNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGK 2012
            S+ C+C PGF       +CLD+DEC       C  GRC N  GSF C+C  GY+  P G 
Sbjct: 542  SFRCVCGPGFRAGPRAAECLDVDECHRV-PPPCDLGRCENTPGSFLCVCPAGYQAAPHGA 600

Query: 2013 NCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCI-DINECDEDPNICLFGS 2071
            +C D +EC   PG C  G C+NL GSFRC+CP G+  +   C  D++EC ++P  C  G 
Sbjct: 601  SCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--RGSACEEDVDECAQEPPPCGPGR 658

Query: 2072 CTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKM 2131
            C NT G F C CP GF     G  C D  +                          C++ 
Sbjct: 659  CDNTAGSFHCACPAGFRSRGPGAPCQDVDE--------------------------CARS 692

Query: 2132 PGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTD 2191
            P       CE    + E +FQ +CP G     +  +  EDV+EC E+   C   +C+N+ 
Sbjct: 693  PPPCTYGRCE----NTEGSFQCVCPMGFQPNTAGSEC-EDVDEC-ENHLACPGQECVNSP 746

Query: 2192 GSFRCE-CPMGYNLDYTGVRCVDTDECSIGNP-CG-NGTCTNVIGSFECNCNEGFE---- 2244
            GSF+C  CP G++L + G RC D DECS G P CG +G CTN  GSF C+C  G+     
Sbjct: 747  GSFQCRTCPSGHHL-HRG-RCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSG 804

Query: 2245 -PGPMMNCEDINECAQNPLLCAF-RCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGL 2302
             PGP   C D+NEC +         C+NT GS+ CTC  GY        C D+DEC+E  
Sbjct: 805  RPGP---CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEE- 860

Query: 2303 HDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTK-PGICENGRCVNIIGSY 2361
              C+S   +C N  G+F CICPPG    PD   C+D +ECR + P +C + RC N  GSY
Sbjct: 861  DLCQSG--ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSY 918

Query: 2362 RC--ECNEGFQSSSSGT-----ECLDNRQGLCFAEVLQTI-----CQMASSSRNLVTKSE 2409
            RC  +C+ G+ +   GT     EC +    +C A+  +       C  A       T   
Sbjct: 919  RCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG 978

Query: 2410 CCCD----GGRGWGHQCELCP-LPGTAQYKKICPHGPGYTTDGR---DIDECKVMPN--- 2458
             C D      R +     +C  LPG+ Q   +C  G     DGR   D++EC+ +     
Sbjct: 979  GCQDVDECRNRSFCGAHAVCQNLPGSFQC--LCDQGYEGARDGRHCVDVNECETLQGVCG 1036

Query: 2459 --LCTNGQ------CINTMGSF-----RCF---CKVGY---------------------- 2480
              LC N +      C N+   F     RC       G                       
Sbjct: 1037 AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPP 1096

Query: 2481 -----TTDISGTSCIDLDEC---SQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKD 2532
                 +T   G       EC   + +P  C+ I        +C C  G   +  G  C+ 
Sbjct: 1097 LPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVG---EGWGSGCR- 1152

Query: 2533 LDECQ-TKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNT 2591
            + +C  T+    Q LC +  G      P G         D +EC          G+C NT
Sbjct: 1153 IQQCPGTETAEYQSLCPHGRGYLA---PSGDLSLRR---DVDECQLFRDQVCKSGVCVNT 1206

Query: 2592 PGSFSCECQRGFSLDATGLNCEDVDEC-DGNHRCQHG-CQNILGGYRCGCPQGYIQHYQW 2649
               +SC C  G+      L C D DEC D    C+ G C N +G Y C C    +     
Sbjct: 1207 APGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQ 1266

Query: 2650 NQCVDENECSNPNACGSASCYNTLGS 2675
             +CV     S  +  G   C+  +G+
Sbjct: 1267 RRCVSNESQSLDDNLG--VCWQEVGA 1290



 Score =  372 bits (956), Expect = e-102
 Identities = 274/835 (32%), Positives = 375/835 (44%), Gaps = 104/835 (12%)

Query: 1959 CYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTN 2018
            C  GFE   N  C D+DEC++  G  C++G C N  G + C+C +G+ L     +CI  +
Sbjct: 277  CPTGFERV-NGSCEDVDECAT--GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 333

Query: 2019 EC---------VALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICL- 2068
                       V   G CS    +N+     C C    +     C           +C  
Sbjct: 334  VISEAKGPCFRVLRDGGCSLPILRNITKQI-CCCSRVGKAWGRGC----------QLCPP 382

Query: 2069 FGSCTNTPGGFQCLCP--PGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKC 2126
            FGS      GF+ +CP  PG+  S +  R ++TR          G+   P+   +     
Sbjct: 383  FGS-----EGFREICPAGPGYHYSASDLR-YNTRPL--------GQ-EPPRVSLSQPRTL 427

Query: 2127 CCSKMPGEGWGDPCELCPKDD---------EVAFQDLCPYGHGTVPSLHDTREDVNECLE 2177
              +  P  G+     L P+ +         E+    +  +   T P + ++      C  
Sbjct: 428  PATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAW---TGPEIPESGPSSGMCQR 484

Query: 2178 SPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDEC-SIGNPCGNGTCTNVIGSFE 2236
            +P +C  G+CI+    + C C  G+ L   G RC+D DEC  +  PC  G C N  GSF 
Sbjct: 485  NPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFR 544

Query: 2237 CNCNEGFEPGP-MMNCEDINECAQNPLLCAF-RCMNTFGSYECTCPIGYALREDQKMCKD 2294
            C C  GF  GP    C D++EC + P  C   RC NT GS+ C CP GY        C+D
Sbjct: 545  CVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQD 604

Query: 2295 LDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECRTKPGICENGR 2353
            +DEC +    C  RG  CKNL G+F C+CP G      G  C  D +EC  +P  C  GR
Sbjct: 605  VDECTQSPGLC-GRG-ACKNLPGSFRCVCPAGFR----GSACEEDVDECAQEPPPCGPGR 658

Query: 2354 CVNIIGSYRCECNEGFQSSSSGTECLDNRQ----------GLC--FAEVLQTICQMASSS 2401
            C N  GS+ C C  GF+S   G  C D  +          G C       Q +C M    
Sbjct: 659  CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 718

Query: 2402 RNLVTKSECC--CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR--DIDECKV-M 2456
                ++ E    C+       Q E    PG+ Q  + CP G  +   GR  D+DEC    
Sbjct: 719  NTAGSECEDVDECENHLACPGQ-ECVNSPGSFQC-RTCPSG-HHLHRGRCTDVDECSSGA 775

Query: 2457 PNLCTNGQCINTMGSFRCFCKVGYTTDISGT--SCIDLDECSQSPKPCNY-ICKNTEGSY 2513
            P    +G C NT GSFRC C  GY    SG    C D++EC +      +  C NT+GS+
Sbjct: 776  PPCGPHGHCTNTEGSFRCSCAPGYRAP-SGRPGPCADVNECLEGDFCFPHGECLNTDGSF 834

Query: 2514 QCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFT--QHHTACID 2571
             C+C  GY     G +C D+DEC  +      +C NT G F C CPPG        +C+D
Sbjct: 835  ACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLD 894

Query: 2572 NNECGSQ-PSLCGAKGICQNTPGSFSC--ECQRGFSLDATGLNCEDVDECD--GNHRC-Q 2625
             +EC  + P+LCG++  C+N+PGS+ C  +C  G+     G  C+DVDEC   G   C  
Sbjct: 895  VDECRERGPALCGSQR-CENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGA 952

Query: 2626 HGCQNILGGYRC--GCPQGYIQHYQWNQCVDENECSNPNACGS-ASCYNTLGSYKCACPS 2682
              C+N  G YRC   C  GY Q      C D +EC N + CG+ A C N  GS++C C  
Sbjct: 953  QRCENTPGSYRCTPACDPGY-QPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQ 1011

Query: 2683 GFSFDQFSSACHDVNECSSSKNPCNYG-CSNTEGGYLCGCP--PGYYRVGQGHCV 2734
            G+   +    C DVNEC + +  C    C N EG +LC CP  P  +    G CV
Sbjct: 1012 GYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1066



 Score =  315 bits (806), Expect = 5e-85
 Identities = 299/1019 (29%), Positives = 385/1019 (37%), Gaps = 251/1019 (24%)

Query: 29   QPQPPPPKPPRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLRGPNV 88
            +P+P P   PRP P           S   +  PE  E G   +S + +R  Q  + GP  
Sbjct: 444  EPRPEPRPDPRPGP------ELPLPSIPAWTGPEIPESGP--SSGMCQRNPQ--VCGPGR 493

Query: 89   CGSRFHSYCC---PGWKTLPGGNQCI-------VP------ICRNS-------CGDGFCS 125
            C SR   Y C    G++  P G +CI       VP       C NS       CG GF +
Sbjct: 494  CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 553

Query: 126  RPNMC-------------TCSSGQISSTCGSKSIQQCSV---RCMNGGTCAD-DHCQCQK 168
             P                 C  G+  +T GS  +  C        +G +C D D C    
Sbjct: 554  GPRAAECLDVDECHRVPPPCDLGRCENTPGS-FLCVCPAGYQAAPHGASCQDVDECTQSP 612

Query: 169  GYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQ 228
            G     CG+  C+N         G  RC C  GF G  CE D     C  +         
Sbjct: 613  G----LCGRGACKN-------LPGSFRCVCPAGFRGSACEED--VDECAQEPP------- 652

Query: 229  LTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQ 288
                 C    C  T G      C  CPA       GF        CQDVDEC   P  C 
Sbjct: 653  ----PCGPGRCDNTAG---SFHC-ACPA-------GFRSRGPGAPCQDVDECARSPPPCT 697

Query: 289  GGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFC-VCPR 347
             G C NT GSF+C CP G + +    +CED+DEC      C   EC N+ GS+ C  CP 
Sbjct: 698  YGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLA-CPGQECVNSPGSFQCRTCPS 756

Query: 348  GYVTSTDGSRCIDQRTGMCFSGL----VNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPE 403
            G+       RC D     C SG      +G C           +C C PG          
Sbjct: 757  GH--HLHRGRCTD--VDECSSGAPPCGPHGHCT----NTEGSFRCSCAPG---------- 798

Query: 404  ACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPG 463
                     YR              +   RPG        P  + N    G   F   P 
Sbjct: 799  ---------YR--------------APSGRPG--------PCADVNECLEGDFCF---PH 824

Query: 464  GNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNM 523
            G   +     A   A G  P   G + L+  +D C    +LC +G C  T  S+ C C  
Sbjct: 825  GECLNTDGSFACTCAPGYRPGPRGASCLD--VDECSEE-DLCQSGICTNTDGSFECICPP 881

Query: 524  GYKQDAN-GDCIDVDECTSNP---CTNGDCVNTPGSYYC--KCHAGFQRTPTKQACIDID 577
            G++   +   C+DVDEC       C +  C N+PGSY C   C  G+   P +  C D+D
Sbjct: 882  GHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGP-EGTCDDVD 940

Query: 578  ECIQNG-VLCKNGRCVNTDGSFQC--ICNAGFELTTDGKNCVDHDECTTTNMC-LNGMCI 633
            EC + G  +C   RC NT GS++C   C+ G++  T G  C D DEC   + C  + +C 
Sbjct: 941  ECQEYGPEICGAQRCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRSFCGAHAVCQ 999

Query: 634  NEDGSFKCICKPGFVLAPNGRYCTDVDECQT-PGICMNGHCINSEGSFRCDCP--PGLAV 690
            N  GSF+C+C  G+  A +GR+C DV+EC+T  G+C    C N EGSF C CP  P    
Sbjct: 1000 NLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFD 1059

Query: 691  GMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGA---------------------------- 722
             M GR CV     +  + G +      P   A                            
Sbjct: 1060 PMTGR-CVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYF 1118

Query: 723  ---------------VTKSECCCANPDYGFGEPC--QPCPAKNSAEFHGLCSSGVGITVD 765
                           VT  ECCC   + G+G  C  Q CP   +AE+  LC  G G    
Sbjct: 1119 DTAAPDACDNILARNVTWQECCCTVGE-GWGSGCRIQQCPGTETAEYQSLCPHGRGYLAP 1177

Query: 766  G------RDINECALDPD-ICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNR 818
                   RD++EC L  D +C +G+C N    Y C C++GY        CID DEC    
Sbjct: 1178 SGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEE 1237

Query: 819  LLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECS 878
              C+ G C NT GSY CTC P  V       C   NE +S                    
Sbjct: 1238 PACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQS-------------------- 1276

Query: 879  PGSKLSSTGLICIDSLKGTCWLNI-QDSRC-EVNINGATLKSECCATLGAAWGSPCERC 935
                        +D   G CW  +  D  C    ++     +ECC   G AWG  C  C
Sbjct: 1277 ------------LDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALC 1323



 Score =  310 bits (795), Expect = 1e-83
 Identities = 184/517 (35%), Positives = 244/517 (47%), Gaps = 59/517 (11%)

Query: 2257 CAQNPLLCA-FRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNL 2315
            C +NP +C   RC++    Y C C  G+ L      C D+DEC      C      C+N 
Sbjct: 482  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPG--RCENS 539

Query: 2316 IGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSG 2375
             G+F C+C PG    P    C+D +EC   P  C+ GRC N  GS+ C C  G+Q++  G
Sbjct: 540  PGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHG 599

Query: 2376 TECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKK 2435
              C D  +                      T+S   C  GRG    C+   LPG+  ++ 
Sbjct: 600  ASCQDVDE---------------------CTQSPGLC--GRG---ACK--NLPGS--FRC 629

Query: 2436 ICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDEC 2495
            +CP G   +    D+DEC   P  C  G+C NT GSF C C  G+ +   G  C D+DEC
Sbjct: 630  VCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDEC 689

Query: 2496 SQSPKPCNY-ICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGF 2554
            ++SP PC Y  C+NTEGS+QC CP G+     G  C+D+DEC+         CVN+ G F
Sbjct: 690  ARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSF 749

Query: 2555 TCK-CPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLN-C 2612
             C+ CP G   H   C D +EC S    CG  G C NT GSF C C  G+   +     C
Sbjct: 750  QCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPC 809

Query: 2613 EDVDEC-DGNHRCQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCY 2670
             DV+EC +G+    HG C N  G + C C  GY    +   C+D +ECS  + C S  C 
Sbjct: 810  ADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICT 869

Query: 2671 NTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYG---CSNTEGGYLC--GCPPGY 2725
            NT GS++C CP G       ++C DV+EC   + P   G   C N+ G Y C   C PGY
Sbjct: 870  NTDGSFECICPPGHRAGPDLASCLDVDEC-RERGPALCGSQRCENSPGSYRCVRDCDPGY 928

Query: 2726 YRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEAC 2762
            +   +G C                +VDE     PE C
Sbjct: 929  HAGPEGTC---------------DDVDECQEYGPEIC 950



 Score =  235 bits (599), Expect = 5e-61
 Identities = 168/517 (32%), Positives = 229/517 (44%), Gaps = 81/517 (15%)

Query: 2268 CMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI----- 2322
            C       EC  P+   LR  +  C+     A G+HDC+    +C   +G    +     
Sbjct: 222  CFRELRGGECASPLP-GLRTQEVCCRGAG-LAWGVHDCQ----LCSERLGNSERVSAPDG 275

Query: 2323 -CPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDN 2381
             CP G  R      C D +EC T  G C++G C N  G Y C C +GF   SS + C+  
Sbjct: 276  PCPTGFERV--NGSCEDVDECATG-GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQ 332

Query: 2382 R-----QGLCFAEVLQTICQMASSSRNLVTKSECCCDG-GRGWGHQCELCPLPGTAQYKK 2435
                  +G CF  +    C +    RN +TK  CCC   G+ WG  C+LCP  G+  +++
Sbjct: 333  HVISEAKGPCFRVLRDGGCSLPIL-RN-ITKQICCCSRVGKAWGRGCQLCPPFGSEGFRE 390

Query: 2436 ICPHGPGYTTDGRD----------------IDECKVMPNLCTNGQCINTMGSFRCFCKVG 2479
            ICP GPGY     D                + + + +P   T+      + + R   +  
Sbjct: 391  ICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLP--ATSRPSAGFLPTHRLEPRPE 448

Query: 2480 YTTD-----------ISGTSCIDLDECSQSPKPCN---YICKNTEGSYQC-SCPRGYV-- 2522
               D           I   +  ++ E   S   C     +C    G  +C S P GY   
Sbjct: 449  PRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVC----GPGRCISRPSGYTCA 504

Query: 2523 ------LQEDGKTCKDLDECQTKQHNC-QFLCVNTLGGFTCKCPPGFTQHHTA--CIDNN 2573
                  L   G  C D+DEC+     C    C N+ G F C C PGF     A  C+D +
Sbjct: 505  CDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVD 564

Query: 2574 ECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC-DGNHRCQHG-CQNI 2631
            EC   P  C   G C+NTPGSF C C  G+     G +C+DVDEC      C  G C+N+
Sbjct: 565  ECHRVPPPCDL-GRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNL 623

Query: 2632 LGGYRCGCPQGYIQHYQWNQC-VDENECS-NPNACGSASCYNTLGSYKCACPSGFSFDQF 2689
             G +RC CP G    ++ + C  D +EC+  P  CG   C NT GS+ CACP+GF     
Sbjct: 624  PGSFRCVCPAG----FRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGP 679

Query: 2690 SSACHDVNECSSSKNPCNYG-CSNTEGGYLCGCPPGY 2725
             + C DV+EC+ S  PC YG C NTEG + C CP G+
Sbjct: 680  GAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGF 716



 Score =  129 bits (324), Expect = 4e-29
 Identities = 108/389 (27%), Positives = 152/389 (39%), Gaps = 50/389 (12%)

Query: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWG-HQCELCPLPGTAQYKKICPHGPG 2442
            G CF E+    C  AS    L T+  CC   G  WG H C+LC        +   P GP 
Sbjct: 220  GYCFRELRGGEC--ASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPC 277

Query: 2443 YTTDGR------DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECS 2496
             T   R      D+DEC      C +G+C NT G + C C  G+  D S +SCI     S
Sbjct: 278  PTGFERVNGSCEDVDECAT-GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVIS 336

Query: 2497 QSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTC 2556
            ++  PC  + ++      CS P    + +    C  + +   +   CQ        GF  
Sbjct: 337  EAKGPCFRVLRDG----GCSLPILRNITKQICCCSRVGKAWGR--GCQLCPPFGSEGFRE 390

Query: 2557 KCPPGFTQHHTAC---IDNNECGSQP---SLCGAKGI-CQNTPGSFSCECQR-------- 2601
             CP G   H++A     +    G +P   SL   + +   + P +      R        
Sbjct: 391  ICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPR 450

Query: 2602 -----GFSLDATGLNC----EDVDECDGNHRCQHG--------CQNILGGYRCGCPQGYI 2644
                 G  L    +      E  +    +  CQ          C +   GY C C  G+ 
Sbjct: 451  PDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFR 510

Query: 2645 QHYQWNQCVDENECSN-PNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSK 2703
               Q  +C+D +EC   P  C    C N+ GS++C C  GF     ++ C DV+EC    
Sbjct: 511  LSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVP 570

Query: 2704 NPCNYG-CSNTEGGYLCGCPPGYYRVGQG 2731
             PC+ G C NT G +LC CP GY     G
Sbjct: 571  PPCDLGRCENTPGSFLCVCPAGYQAAPHG 599



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 35/99 (35%), Positives = 51/99 (51%), Gaps = 11/99 (11%)

Query: 1262 GSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMK 1321
            GSY  S +E Y  + +   C  +D C N       G+C  +P  + C C+DG+   M   
Sbjct: 1452 GSYAGSLAEPYEEL-EAEECGILDGCTN-------GRCVRVPEGFTCRCFDGYRLDMTRM 1503

Query: 1322 TCIDVNECD---LNSNICMFGECENTKGSFICHCQLGYS 1357
             C+D+NECD     S +C+   C NT GSF C C+ G++
Sbjct: 1504 ACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFA 1542



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 33/77 (42%), Positives = 41/77 (53%), Gaps = 6/77 (7%)

Query: 1491 DIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDEC-----ADPINCVNG 1545
            + +EC   + C  G C  +P  F C C DGY LD T   C DI+EC     A P+ CVN 
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL-CVNA 1524

Query: 1546 LCVNTPGRYECNCPPDF 1562
             C+NT G + C C P F
Sbjct: 1525 RCLNTDGSFRCICRPGF 1541



 Score = 66.2 bits (160), Expect = 4e-10
 Identities = 37/96 (38%), Positives = 45/96 (46%), Gaps = 7/96 (7%)

Query: 2156 PYGHGTVPSLHDTREDVN--ECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVD 2213
            P G     SL +  E++   EC    G C+NG+C+     F C C  GY LD T + CVD
Sbjct: 1449 PEGGSYAGSLAEPYEELEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1507

Query: 2214 TDECSIGNP----CGNGTCTNVIGSFECNCNEGFEP 2245
             +EC         C N  C N  GSF C C  GF P
Sbjct: 1508 INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP 1543



 Score = 65.9 bits (159), Expect = 6e-10
 Identities = 30/93 (32%), Positives = 44/93 (47%), Gaps = 4/93 (4%)

Query: 616  VDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQ----TPGICMNG 671
            ++ +EC   + C NG C+     F C C  G+ L      C D++EC        +C+N 
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 672  HCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRS 704
             C+N++GSFRC C PG A       C     R+
Sbjct: 1525 RCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA 1557



 Score = 65.5 bits (158), Expect = 7e-10
 Identities = 33/91 (36%), Positives = 44/91 (48%), Gaps = 6/91 (6%)

Query: 2015 IDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPN---ICLF 2069
            ++  EC  L G C+ G C  +   F C C  GY +      C+DINECDE      +C+ 
Sbjct: 1465 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1523

Query: 2070 GSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR 2100
              C NT G F+C+C PGF  +     C   R
Sbjct: 1524 ARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1554



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 33/79 (41%), Positives = 39/79 (49%), Gaps = 5/79 (6%)

Query: 1972 LDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNEC---VALPGSCS 2028
            L+ +EC    G  C NGRC      F C C +GY L      C+D NEC    A    C 
Sbjct: 1465 LEAEECGILDG--CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV 1522

Query: 2029 PGTCQNLEGSFRCICPPGY 2047
               C N +GSFRCIC PG+
Sbjct: 1523 NARCLNTDGSFRCICRPGF 1541



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 28/77 (36%), Positives = 45/77 (58%), Gaps = 5/77 (6%)

Query: 2449 DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQ----SPKPCNY 2504
            + +EC ++   CTNG+C+     F C C  GY  D++  +C+D++EC +    SP   N 
Sbjct: 1466 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 2505 ICKNTEGSYQCSCPRGY 2521
             C NT+GS++C C  G+
Sbjct: 1525 RCLNTDGSFRCICRPGF 1541



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 44/142 (30%), Positives = 64/142 (45%), Gaps = 16/142 (11%)

Query: 2103 FCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWG-DPCELCPK----DDEVAFQD-LCP 2156
            +CF     G+C+ P     T+  CC  +  G  WG   C+LC +     + V+  D  CP
Sbjct: 221  YCFRELRGGECASPLPGLRTQEVCC--RGAGLAWGVHDCQLCSERLGNSERVSAPDGPCP 278

Query: 2157 YGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDE 2216
             G   V   + + EDV+EC    G C +G+C NT G + C CP G+ LD +   C+    
Sbjct: 279  TGFERV---NGSCEDVDECATG-GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV 334

Query: 2217 CSIGNPCGNGTCTNVIGSFECN 2238
             S       G C  V+    C+
Sbjct: 335  ISE----AKGPCFRVLRDGGCS 352



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 33/86 (38%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 2212 VDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPG-PMMNCEDINEC----AQNPLLCAF 2266
            ++ +EC I + C NG C  V   F C C +G+      M C DINEC    A +PL    
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 2267 RCMNTFGSYECTCPIGYALREDQKMC 2292
            RC+NT GS+ C C  G+A       C
Sbjct: 1525 RCLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 35/91 (38%), Positives = 47/91 (51%), Gaps = 12/91 (13%)

Query: 1115 DIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPL---LCRG 1171
            + +EC I  D C +G CV  P  F C CF+GY      M  C+DI+EC+       LC  
Sbjct: 1466 EAEECGIL-DGCTNGRCVRVPEGFTCRCFDGYRLDMTRMA-CVDINECDEAEAASPLCVN 1523

Query: 1172 GTCVNTEGSFQCDCPLG-------HELSPSR 1195
              C+NT+GSF+C C  G       H  +P+R
Sbjct: 1524 ARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1554



 Score = 63.2 bits (152), Expect = 4e-09
 Identities = 28/82 (34%), Positives = 45/82 (54%), Gaps = 6/82 (7%)

Query: 1891 VDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHP-----CGN 1945
            ++  EC  I + C++G CV +   + C C +G++    +  C+D++EC+        C N
Sbjct: 1465 LEAEEC-GILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1523

Query: 1946 GTCKNTVGSYNCLCYPGFELTH 1967
              C NT GS+ C+C PGF  TH
Sbjct: 1524 ARCLNTDGSFRCICRPGFAPTH 1545



 Score = 62.4 bits (150), Expect = 6e-09
 Identities = 32/90 (35%), Positives = 43/90 (47%), Gaps = 13/90 (14%)

Query: 1405 KCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGD--GFTCSDVDECAEN---INL 1459
            +C  LD C+NG        +CV  P  + C C +G+  D     C D++EC E      L
Sbjct: 1469 ECGILDGCTNG--------RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL 1520

Query: 1460 CENGQCLNVPGAYRCECEMGFTPASDSRSC 1489
            C N +CLN  G++RC C  GF P      C
Sbjct: 1521 CVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 5/88 (5%)

Query: 1199 VDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGG----CD 1254
            ++  EC + D  C NG+CV +   + C C  GY+    R  C DI+EC           +
Sbjct: 1465 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1523

Query: 1255 TQCTNSEGSYECSCSEGYALMPDGRSCA 1282
             +C N++GS+ C C  G+A       CA
Sbjct: 1524 ARCLNTDGSFRCICRPGFAPTHQPHHCA 1551



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 28/90 (31%), Positives = 40/90 (44%), Gaps = 4/90 (4%)

Query: 276  DVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDEC---SIIPGICETG 332
            + +EC  + G C  G C+     F CRC  G++   T   C DI+EC        +C   
Sbjct: 1466 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 333  ECSNTVGSYFCVCPRGYVTSTDGSRCIDQR 362
             C NT GS+ C+C  G+  +     C   R
Sbjct: 1525 RCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1554



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 31/90 (34%), Positives = 41/90 (45%), Gaps = 4/90 (4%)

Query: 1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDEC---FAHPGVCGPG 1706
            + +EC  L G C  G C+     F C C  GY L      C DI+EC    A   +C   
Sbjct: 1466 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 1707 TCYNTLGNYTCICPPEYMQVNGGHNCMDMR 1736
             C NT G++ CIC P +   +  H+C   R
Sbjct: 1525 RCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1554



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 4/86 (4%)

Query: 1933 MDVDECE-RHPCGNGTCKNTVGSYNCLCYPGFELTHNN-DCLDIDEC--SSFFGQVCRNG 1988
            ++ +EC     C NG C      + C C+ G+ L      C+DI+EC  +     +C N 
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 1989 RCFNEIGSFKCLCNEGYELTPDGKNC 2014
            RC N  GSF+C+C  G+  T    +C
Sbjct: 1525 RCLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 29/79 (36%), Positives = 42/79 (53%), Gaps = 5/79 (6%)

Query: 1807 VDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGD---NLCQR 1863
            ++ +EC  + G C NG C+     F C C  G+  +   + C DI+EC   +    LC  
Sbjct: 1465 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV- 1522

Query: 1864 NADCINSPGSYRCECAAGF 1882
            NA C+N+ GS+RC C  GF
Sbjct: 1523 NARCLNTDGSFRCICRPGF 1541



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 26/85 (30%), Positives = 41/85 (48%), Gaps = 3/85 (3%)

Query: 1242 DIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDEC---ENNPDICDGGQ 1298
            + +EC I++G  + +C      + C C +GY L     +C DI+EC   E    +C   +
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525

Query: 1299 CTNIPGEYRCLCYDGFMASMDMKTC 1323
            C N  G +RC+C  GF  +     C
Sbjct: 1526 CLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 26/84 (30%), Positives = 38/84 (45%), Gaps = 4/84 (4%)

Query: 2653 VDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNEC----SSSKNPCNY 2708
            ++  EC   + C +  C      + C C  G+  D    AC D+NEC    ++S    N 
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 2709 GCSNTEGGYLCGCPPGYYRVGQGH 2732
             C NT+G + C C PG+    Q H
Sbjct: 1525 RCLNTDGSFRCICRPGFAPTHQPH 1548



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 26/77 (33%), Positives = 39/77 (50%), Gaps = 5/77 (6%)

Query: 1449 DVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDEC----SFQNICVFG 1504
            + +EC   ++ C NG+C+ VP  + C C  G+       +C DI+EC    +   +CV  
Sbjct: 1466 EAEECGI-LDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 1505 TCNNLPGMFHCICDDGY 1521
             C N  G F CIC  G+
Sbjct: 1525 RCLNTDGSFRCICRPGF 1541



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 12/89 (13%)

Query: 1848 CEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPN---VC 1903
            C  +D C+NG         C+  P  + C C  G++L     ACVD NEC E      +C
Sbjct: 1470 CGILDGCTNGR--------CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLC 1521

Query: 1904 SHGLCVDLQGSYQCICHNGFKASQDQTMC 1932
             +  C++  GS++CIC  GF  +     C
Sbjct: 1522 VNARCLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 71/269 (26%), Positives = 96/269 (35%), Gaps = 61/269 (22%)

Query: 29   QPQPP--PPKPPRPQPPPQQVRSAT--AGSEGGFLAPEYREEGAAVA-SRVRRRG---QQ 80
            QPQ P  P  P RP PPP   R +T   G  G      Y +  A  A   +  R    Q+
Sbjct: 1079 QPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQE 1138

Query: 81   DVLRGPNVCGSRFHSYCCPGWKT------LPGGNQCIVPI-----------CR----NSC 119
                     GS      CPG +T       P G   + P            C+      C
Sbjct: 1139 CCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVC 1198

Query: 120  GDGFC--SRPN-MCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKG----YIG 172
              G C  + P   C CS+G    T          + C++   CAD+   C+ G     +G
Sbjct: 1199 KSGVCVNTAPGYSCYCSNGYYYHT--------QRLECIDNDECADEEPACEGGRCVNTVG 1250

Query: 173  TY---CGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVN-NQMCQGQ 228
            +Y   C  P+  +G Q   RC+           +      D   G C+ +V  + +C   
Sbjct: 1251 SYHCTCEPPLVLDGSQR--RCV-----------SNESQSLDDNLGVCWQEVGADLVCSHP 1297

Query: 229  LTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257
                  T T CC   G AWG  C +CPAQ
Sbjct: 1298 RLDRQATYTECCCLYGEAWGMDCALCPAQ 1326



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 37/166 (22%), Positives = 67/166 (40%), Gaps = 21/166 (12%)

Query: 90  GSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQC 149
           G R    CC G     G + C +   R    +   +    C     +++ +C  + + +C
Sbjct: 237 GLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSC--EDVDEC 294

Query: 150 SVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCER 209
           +     GG C    C   +G  G  C   VC +G       +  +R +C+      + + 
Sbjct: 295 AT----GGRCQHGECANTRG--GYTC---VCPDGF-----LLDSSRSSCISQHVISEAK- 339

Query: 210 DYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCP 255
               GPCF  + +  C   +   +  +  CC+ +G+AWG  C++CP
Sbjct: 340 ----GPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCP 381



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 3/78 (3%)

Query: 1324 IDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECE--IGAHNCDMH 1381
            ++  EC +    C  G C      F C C  GY +      C D++EC+    A    ++
Sbjct: 1465 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1523

Query: 1382 ASCLNIPGSFKCSCREGW 1399
            A CLN  GSF+C CR G+
Sbjct: 1524 ARCLNTDGSFRCICRPGF 1541



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 28/77 (36%), Positives = 37/77 (48%), Gaps = 5/77 (6%)

Query: 2614 DVDECDGNHRCQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNA----CGSAS 2668
            + +EC     C +G C  +  G+ C C  GY        CVD NEC    A    C +A 
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525

Query: 2669 CYNTLGSYKCACPSGFS 2685
            C NT GS++C C  GF+
Sbjct: 1526 CLNTDGSFRCICRPGFA 1542



 Score = 52.4 bits (124), Expect = 7e-06
 Identities = 33/103 (32%), Positives = 45/103 (43%), Gaps = 5/103 (4%)

Query: 1739 FCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWN-KPCEPCPTPGTADFKTICGNIPGF 1797
            +C+R   G  C + LP   T+ +CC     G AW    C+ C        +    + P  
Sbjct: 221  YCFRELRGGECASPLPGLRTQEVCC--RGAGLAWGVHDCQLCSERLGNSERVSAPDGPCP 278

Query: 1798 T-FDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGF 1839
            T F+   G   D+DEC    G C +G C N  G + C CP GF
Sbjct: 279  TGFERVNGSCEDVDECAT-GGRCQHGECANTRGGYTCVCPDGF 320



 Score = 52.4 bits (124), Expect = 7e-06
 Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 7/88 (7%)

Query: 2570 IDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECD----GNHRCQ 2625
            ++  ECG         G C   P  F+C C  G+ LD T + C D++ECD     +  C 
Sbjct: 1465 LEAEECGILDGC--TNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV 1522

Query: 2626 HG-CQNILGGYRCGCPQGYIQHYQWNQC 2652
            +  C N  G +RC C  G+   +Q + C
Sbjct: 1523 NARCLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 48.9 bits (115), Expect = 7e-05
 Identities = 35/113 (30%), Positives = 43/113 (38%), Gaps = 13/113 (11%)

Query: 2273 GSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPD 2332
            GSY  +    Y   E ++ C  LD C  G          C  +   F C C  G      
Sbjct: 1452 GSYAGSLAEPYEELEAEE-CGILDGCTNG---------RCVRVPEGFTCRCFDGYRLDMT 1501

Query: 2333 GEGCVDENEC---RTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNR 2382
               CVD NEC        +C N RC+N  GS+RC C  GF  +     C   R
Sbjct: 1502 RMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1554



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 4/81 (4%)

Query: 2490 IDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFL--- 2546
            ++ +EC       N  C      + C C  GY L      C D++EC   +         
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 2547 -CVNTLGGFTCKCPPGFTQHH 2566
             C+NT G F C C PGF   H
Sbjct: 1525 RCLNTDGSFRCICRPGFAPTH 1545



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 11/99 (11%)

Query: 2233 GSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMC 2292
            GS+  +  E +E      C  ++ C         RC+     + C C  GY L   +  C
Sbjct: 1452 GSYAGSLAEPYEELEAEECGILDGCTNG------RCVRVPEGFTCRCFDGYRLDMTRMAC 1505

Query: 2293 KDLDECAEGLHDCESR---GMMCKNLIGTFMCICPPGMA 2328
             D++EC E   +  S       C N  G+F CIC PG A
Sbjct: 1506 VDINECDEA--EAASPLCVNARCLNTDGSFRCICRPGFA 1542



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 3/53 (5%)

Query: 1791 CGNIPGFTFDIHTGKAVDIDECKEIPG---ICANGVCINQIGSFRCECPTGFS 1840
            C    G+  D+     VDI+EC E      +C N  C+N  GSFRC C  GF+
Sbjct: 1490 CRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFA 1542



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 16/35 (45%), Positives = 22/35 (62%)

Query: 2446 DGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGY 2480
            D  + DE +    LC N +C+NT GSFRC C+ G+
Sbjct: 1507 DINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1541



 Score = 39.7 bits (91), Expect = 0.044
 Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 3/61 (4%)

Query: 1633 CPGGEGFRPNPITIILEDIDECQELPG---LCQGGNCINTFGSFQCECPQGYYLSEDTRI 1689
            C   +G+R +   +   DI+EC E      LC    C+NT GSF+C C  G+  +     
Sbjct: 1490 CRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHH 1549

Query: 1690 C 1690
            C
Sbjct: 1550 C 1550



 Score = 38.1 bits (87), Expect = 0.13
 Identities = 15/42 (35%), Positives = 22/42 (52%)

Query: 1532 DIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVD 1573
            + +EC     C NG CV  P  + C C   ++L+ T + CVD
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1507



 Score = 35.8 bits (81), Expect = 0.64
 Identities = 23/74 (31%), Positives = 31/74 (41%), Gaps = 14/74 (18%)

Query: 149 CSVRCMNGGT-------CADDHCQCQKGYI--GTYCGQP-----VCENGCQNGGRCIGPN 194
           C +RC++G T       CA  +          G   G P     +C   C NGG C+ P+
Sbjct: 41  CGLRCVHGPTGSRCTPTCAPRNATSVDSGAPGGAAPGGPGFRAFLCPLICHNGGVCVKPD 100

Query: 195 RCACVYGFTGPQCE 208
           RC C   F G  C+
Sbjct: 101 RCLCPPDFAGKFCQ 114


>gi|110347412 latent transforming growth factor beta binding protein 4
            isoform b [Homo sapiens]
          Length = 1587

 Score =  524 bits (1350), Expect = e-148
 Identities = 369/1186 (31%), Positives = 490/1186 (41%), Gaps = 172/1186 (14%)

Query: 706  CYGGIKKGVCVRPFPGAVTKSECCCANPDYGFG-EPCQPCPAK--NSAEFH---GLCSSG 759
            C+  ++ G C  P PG  T+ E CC      +G   CQ C  +  NS       G C +G
Sbjct: 252  CFRELRGGECASPLPGLRTQ-EVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTG 310

Query: 760  VGITVDG--RDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVN 817
                V+G   D++ECA     C +G C N RG Y C C  G+  D+S  +C  I + +++
Sbjct: 311  FE-RVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVIS 366

Query: 818  RLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFN-CE 876
                  G C        C+ P       +   C  + +     C       + G    C 
Sbjct: 367  EA---KGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICP 423

Query: 877  CSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCE 936
              PG   S++     D    T  L  +  R  ++    TL +    + G       E   
Sbjct: 424  AGPGYHYSAS-----DLRYNTRPLGQEPPRVSLS-QPRTLPATSRPSAGFLPTHRLEPRP 477

Query: 937  LDTACPRG-----LARIKGVTCEDVNE-------CEVFPGVCPNGRCVNSKGSFHCECPE 984
                 PR      L  I   T  ++ E       C+  P VC  GRC++    + C C  
Sbjct: 478  EPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDS 537

Query: 985  GLTLDGTGRVCLDIRMEQCYLKWDEDEC-----------IHPVPGKFRMDACCCAVGAAW 1033
            G  L   G  C+D+           DEC               PG FR   C C  G   
Sbjct: 538  GFRLSPQGTRCIDV-----------DECRRVPPPCAPGRCENSPGSFR---CVCGPGFRA 583

Query: 1034 GTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTI 1093
            G    EC                                D++EC   P  C  G+C NT 
Sbjct: 584  GPRAAEC-------------------------------LDVDECHRVPPPCDLGRCENTP 612

Query: 1094 GSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMM 1153
            GSF C C +G+       +C D+DEC  SP LCG G C N PGSF C C  G+       
Sbjct: 613  GSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEE 672

Query: 1154 KNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRN 1213
                D+DEC + P  C  G C NT GSF C CP G         C D++EC+ S   C  
Sbjct: 673  ----DVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTY 728

Query: 1214 GKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYEC-SCSEGY 1272
            G+C N  G++QC C  G+Q       C D+DEC         +C NS GS++C +C  G+
Sbjct: 729  GRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGH 788

Query: 1273 ALMPDGRSCADIDECENNPDICDG-GQCTNIPGEYRCLCYDGFMASMDMK-TCIDVNECD 1330
             L   GR C D+DEC +    C   G CTN  G +RC C  G+ A       C DVNEC 
Sbjct: 789  HLHR-GR-CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC- 845

Query: 1331 LNSNICM-FGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPG 1389
            L  + C   GEC NT GSF C C  GY        C DVDEC     +      C N  G
Sbjct: 846  LEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS--EEDLCQSGICTNTDG 903

Query: 1390 SFKCSCREGWIGNG--IKCIDLDECSNGTHQCSINAQCVNTPGSYRCA--CSEGF-TGDG 1444
            SF+C C  G         C+D+DEC         + +C N+PGSYRC   C  G+  G  
Sbjct: 904  SFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPE 963

Query: 1445 FTCSDVDECAE-NINLCENGQCLNVPGAYRCE--CEMGFTPASDSRSCQDIDECSFQNIC 1501
             TC DVDEC E    +C   +C N PG+YRC   C+ G+ P      CQD+DEC  ++ C
Sbjct: 964  GTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFC 1022

Query: 1502 -VFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPIN-CVNGLCVNTPGRYECNCP 1559
                 C NLPG F C+CD GYE  R G +C D++EC      C   LC N  G + C CP
Sbjct: 1023 GAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCP 1082

Query: 1560 --PDFQLNPTGVGCVDNRVGNCYL-----------------------------KFGPRGD 1588
              P+ + +P    CV  R                                   + GP G 
Sbjct: 1083 NSPE-EFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGS 1141

Query: 1589 GSL----------SCNTEIGVGVSRSSCCCSLGKAWGNPC--ETCPPVNSTEYYTLCPGG 1636
            G            +C+  +   V+   CCC++G+ WG+ C  + CP   + EY +LCP G
Sbjct: 1142 GRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHG 1201

Query: 1637 EGF-RPNPITIILEDIDECQELPG-LCQGGNCINTFGSFQCECPQGYYLSEDTRICEDID 1694
             G+  P+    +  D+DECQ     +C+ G C+NT   + C C  GYY       C D D
Sbjct: 1202 RGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDND 1261

Query: 1695 ECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNC-------MDMRKSFCYRSYNG- 1746
            EC      C  G C NT+G+Y C C P  +       C       +D     C++     
Sbjct: 1262 ECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGAD 1321

Query: 1747 TTCEN-ELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC 1791
              C +  L    T   CCC Y  G+AW   C  CP   + DF+ +C
Sbjct: 1322 LVCSHPRLDRQATYTECCCLY--GEAWGMDCALCPAQDSDDFEALC 1365



 Score =  491 bits (1264), Expect = e-138
 Identities = 338/1034 (32%), Positives = 471/1034 (45%), Gaps = 139/1034 (13%)

Query: 1677 CPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMR 1736
            CP G+     +  CED+DEC A  G C  G C NT G YTC+CP  ++  +   +C+   
Sbjct: 307  CPTGFERVNGS--CEDVDEC-ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 363

Query: 1737 -----KSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC 1791
                 K  C+R      C   +  N+TK++CCC+  VGKAW + C+ CP  G+  F+ IC
Sbjct: 364  VISEAKGPCFRVLRDGGCSLPILRNITKQICCCS-RVGKAWGRGCQLCPPFGSEGFREIC 422

Query: 1792 GNIPGFTFDIHTGK-----------AVDIDECKEIPGIC---ANGVCINQIGSFRCECPT 1837
               PG+ +     +            V + + + +P      A  +  +++       P 
Sbjct: 423  PAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPD 482

Query: 1838 GFSYNDLLLVC------EDIDECSNGDNLCQRNAD------CINSPGSYRCECAAGFKLS 1885
                 +L L         +I E      +CQRN        CI+ P  Y C C +GF+LS
Sbjct: 483  PRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLS 542

Query: 1886 PNGA-CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECER--HP 1942
            P G  C+D +EC  +P  C+ G C +  GS++C+C  GF+A      C+DVDEC R   P
Sbjct: 543  PQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPP 602

Query: 1943 CGNGTCKNTVGSYNCLCYPGFELT-HNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLC 2001
            C  G C+NT GS+ C+C  G++   H   C D+DEC+   G +C  G C N  GSF+C+C
Sbjct: 603  CDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPG-LCGRGACKNLPGSFRCVC 661

Query: 2002 NEGYELTPDGKNCI-DTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDIN 2058
              G+     G  C  D +EC   P  C PG C N  GSF C CP G+  +     C D++
Sbjct: 662  PAGFR----GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVD 717

Query: 2059 ECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQ---------SFCFTNFE 2109
            EC   P  C +G C NT G FQC+CP GF  +  G  C D  +           C  +  
Sbjct: 718  ECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPG 777

Query: 2110 NGKC-SVPKAFNTTKAKC-----CCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVP 2163
            + +C + P   +  + +C     C S  P  G    C     + E +F+  C  G+    
Sbjct: 778  SFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCT----NTEGSFRCSCAPGYRAPS 833

Query: 2164 SLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPC 2223
                   DVNECLE      +G+C+NTDGSF C C  GY     G  C+D DECS  + C
Sbjct: 834  GRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLC 893

Query: 2224 GNGTCTNVIGSFECNCNEGFEPGP-MMNCEDINECAQ-NPLLC-AFRCMNTFGSYECT-- 2278
             +G CTN  GSFEC C  G   GP + +C D++EC +  P LC + RC N+ GSY C   
Sbjct: 894  QSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRD 953

Query: 2279 CPIGYALREDQKMCKDLDECAE-GLHDCESRGMMCKNLIGTFMC--ICPPGMARRPDGEG 2335
            C  GY     +  C D+DEC E G   C ++   C+N  G++ C   C PG    P G G
Sbjct: 954  CDPGYH-AGPEGTCDDVDECQEYGPEICGAQ--RCENTPGSYRCTPACDPGYQPTPGG-G 1009

Query: 2336 CVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTIC 2395
            C D +ECR +     +  C N+ GS++C C++G++ +  G  C+D  +     E LQ +C
Sbjct: 1010 CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNE----CETLQGVC 1065

Query: 2396 QMASSSRNLVTKSECCCDG---------GRGWGHQCELCPLPGT---AQYKKICPHGP-- 2441
              A+   N+     C C           GR    +      PG+   A    + P  P  
Sbjct: 1066 G-AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPP 1124

Query: 2442 ------------GYTTDGRDIDEC---KVMPNLCTNGQCINTMGSFRCFCKVGYTTDISG 2486
                        G    GR   EC      P+ C N    N      C C VG   +  G
Sbjct: 1125 PPLPRRPSTPRQGPVGSGR--RECYFDTAAPDACDNILARNVTWQ-ECCCTVG---EGWG 1178

Query: 2487 TSCIDLDECSQSPKPCNYICKNTE-GSYQCSCP--RGYVLQE-DGKTCKDLDECQT-KQH 2541
            + C       Q        C  TE   YQ  CP  RGY+    D    +D+DECQ  +  
Sbjct: 1179 SGC----RIQQ--------CPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQ 1226

Query: 2542 NCQF-LCVNTLGGFTCKCPPGFTQH--HTACIDNNECGSQPSLCGAKGICQNTPGSFSCE 2598
             C+  +CVNT  G++C C  G+  H     CIDN+EC  +   C   G C NT GS+ C 
Sbjct: 1227 VCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEG-GRCVNTVGSYHCT 1285

Query: 2599 CQRGFSLDATGLNC 2612
            C+    LD +   C
Sbjct: 1286 CEPPLVLDGSQRRC 1299



 Score =  472 bits (1214), Expect = e-132
 Identities = 368/1217 (30%), Positives = 501/1217 (41%), Gaps = 201/1217 (16%)

Query: 1436 CSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDEC 1495
            C  G  G  +   D   C+E +    N + ++ P      C  GF   + S  C+D+DEC
Sbjct: 274  CCRG-AGLAWGVHDCQLCSERLG---NSERVSAPDG---PCPTGFERVNGS--CEDVDEC 324

Query: 1496 SFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYE 1555
            +    C  G C N  G + C+C DG+ LD +  +C         I+   G C        
Sbjct: 325  ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCIS----QHVISEAKGPCFRVLRDGG 380

Query: 1556 CNCPPDFQLNPTGVGCVDNRVGNCYLK-------FGPRGDGSLSCNTEIGVGVSRSSCC- 1607
            C+ P     N T   C  +RVG  + +       FG  G   + C    G   S S    
Sbjct: 381  CSLP--ILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREI-CPAGPGYHYSASDLRY 437

Query: 1608 -----------CSLGKAWGNPCETCPPVNSTEYYTLCPGGEGF---RPNPITIILE---- 1649
                        SL +    P  + P       + L P  E     RP P   +      
Sbjct: 438  NTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAW 497

Query: 1650 ---DIDE-------CQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAH 1699
               +I E       CQ  P +C  G CI+    + C C  G+ LS     C D+DEC   
Sbjct: 498  TGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRV 557

Query: 1700 PGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTK 1759
            P  C PG C N+ G++ C+C P +        C+D+ +  C+R                 
Sbjct: 558  PPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDE--CHR---------------VP 600

Query: 1760 RMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGIC 1819
              C    ++G+  N       TPG+  F  +C    G+    H     D+DEC + PG+C
Sbjct: 601  PPC----DLGRCEN-------TPGS--FLCVCP--AGYQAAPHGASCQDVDECTQSPGLC 645

Query: 1820 ANGVCINQIGSFRCECPTGFSYNDLLLVC-EDIDECSNGDNLCQRNADCINSPGSYRCEC 1878
              G C N  GSFRC CP GF  +     C ED+DEC+     C     C N+ GS+ C C
Sbjct: 646  GRGACKNLPGSFRCVCPAGFRGS----ACEEDVDECAQEPPPCGPGR-CDNTAGSFHCAC 700

Query: 1879 AAGFK-LSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDE 1937
             AGF+   P   C D +EC   P  C++G C + +GS+QC+C  GF+ +   + C DVDE
Sbjct: 701  PAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE 760

Query: 1938 CERH-PCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGS 1996
            CE H  C    C N+ GS+ C   P     H   C D+DECSS       +G C N  GS
Sbjct: 761  CENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGS 820

Query: 1997 FKCLCNEGYELTPDGK--NCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYE--VKSE 2052
            F+C C  GY   P G+   C D NEC+        G C N +GSF C C PGY    +  
Sbjct: 821  FRCSCAPGYR-APSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 879

Query: 2053 NCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGK 2112
            +C+D++EC E+ ++C  G CTNT G F+C+CPPG     +   C D  +       E G 
Sbjct: 880  SCLDVDECSEE-DLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDEC-----RERG- 932

Query: 2113 CSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDV 2172
               P    + +    C   PG         C +D        C  G+   P    T +DV
Sbjct: 933  ---PALCGSQR----CENSPGS------YRCVRD--------CDPGYHAGP--EGTCDDV 969

Query: 2173 NECLE-SPGICSNGQCINTDGSFRC--ECPMGYNLDYTGVRCVDTDECSIGNPCG-NGTC 2228
            +EC E  P IC   +C NT GS+RC   C  GY     G  C D DEC   + CG +  C
Sbjct: 970  DECQEYGPEICGAQRCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRSFCGAHAVC 1028

Query: 2229 TNVIGSFECNCNEGFEPG-PMMNCEDINECAQNPLLC-AFRCMNTFGSYECTCPIGYALR 2286
             N+ GSF+C C++G+E      +C D+NEC     +C A  C N  GS+ C CP      
Sbjct: 1029 QNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCP------ 1082

Query: 2287 EDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICP-----PGMARRPDGEGCVDENE 2341
                         E       R +  +   GTF    P     P +  RP          
Sbjct: 1083 ----------NSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARP------PPPP 1126

Query: 2342 CRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSS 2401
               +P     G     +GS R EC       ++  +  DN                   +
Sbjct: 1127 LPRRPSTPRQGP----VGSGRREC----YFDTAAPDACDN-----------------ILA 1161

Query: 2402 RNLVTKSECCCDGGRGWGHQCEL--CPLPGTAQYKKICPHGPGYTTDG------RDIDEC 2453
            RN VT  ECCC  G GWG  C +  CP   TA+Y+ +CPHG GY          RD+DEC
Sbjct: 1162 RN-VTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDEC 1220

Query: 2454 KVM-PNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPC-NYICKNTEG 2511
            ++    +C +G C+NT   + C+C  GY        CID DEC+     C    C NT G
Sbjct: 1221 QLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVG 1280

Query: 2512 SYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCP---PGFTQHHTA 2568
            SY C+C    VL    + C   +E Q+   N             C  P      T     
Sbjct: 1281 SYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECC 1339

Query: 2569 CIDNNECGSQPSLCGAK 2585
            C+     G   +LC A+
Sbjct: 1340 CLYGEAWGMDCALCPAQ 1356



 Score =  458 bits (1179), Expect = e-128
 Identities = 293/923 (31%), Positives = 401/923 (43%), Gaps = 156/923 (16%)

Query: 1453 CAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECS-FQNICVFGTCNNLPG 1511
            C  N  +C  G+C++ P  Y C C+ GF  +     C D+DEC      C  G C N PG
Sbjct: 512  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 571

Query: 1512 MFHCICDDGYELDRTGGNCTDIDECAD-PINCVNGLCVNTPGRYECNCPPDFQLNPTGVG 1570
             F C+C  G+        C D+DEC   P  C  G C NTPG + C CP  +Q  P G  
Sbjct: 572  SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGAS 631

Query: 1571 CVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYY 1630
            C D  V  C    G  G G+                           C+  P      + 
Sbjct: 632  CQD--VDECTQSPGLCGRGA---------------------------CKNLPG----SFR 658

Query: 1631 TLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRIC 1690
             +CP G  FR +      ED+DEC + P  C  G C NT GSF C CP G+        C
Sbjct: 659  CVCPAG--FRGSACE---EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPC 713

Query: 1691 EDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCE 1750
            +D+DEC   P  C  G C NT G++ C+CP  +     G  C D+ +           CE
Sbjct: 714  QDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE-----------CE 762

Query: 1751 NELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDID 1810
            N L        C     V    +  C  CP+                   +H G+  D+D
Sbjct: 763  NHLA-------CPGQECVNSPGSFQCRTCPSG----------------HHLHRGRCTDVD 799

Query: 1811 ECKEIPGICA-NGVCINQIGSFRCECPTGF-SYNDLLLVCEDIDECSNGDNLCQRNADCI 1868
            EC      C  +G C N  GSFRC C  G+ + +     C D++EC  GD  C  + +C+
Sbjct: 800  ECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGD-FCFPHGECL 858

Query: 1869 NSPGSYRCECAAGFKLSPNGA-CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQ 1927
            N+ GS+ C CA G++  P GA C+D +EC E  ++C  G+C +  GS++CIC  G +A  
Sbjct: 859  NTDGSFACTCAPGYRPGPRGASCLDVDECSE-EDLCQSGICTNTDGSFECICPPGHRAGP 917

Query: 1928 DQTMCMDVDEC-ERHP--CGNGTCKNTVGSYNCL--CYPGFELTHNNDCLDIDECSSFFG 1982
            D   C+DVDEC ER P  CG+  C+N+ GSY C+  C PG+       C D+DEC  +  
Sbjct: 918  DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGP 977

Query: 1983 QVCRNGRCFNEIGSFKCL--CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFR 2040
            ++C   RC N  GS++C   C+ GY+ TP G  C D +EC       +   CQNL GSF+
Sbjct: 978  EICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQ 1036

Query: 2041 CICPPGYEVKSE--NCIDINECDEDPNICLFGSCTNTPGGF----------------QCL 2082
            C+C  GYE   +  +C+D+NEC+    +C    C N  G F                +C+
Sbjct: 1037 CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1096

Query: 2083 CPPGFVLSDNG---------------------RRCFDTRQS--------FCFTNFENGKC 2113
             P     +  G                     RR    RQ           F       C
Sbjct: 1097 PPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDAC 1156

Query: 2114 SVPKAFNTTKAKCCCSKMPGEGWGDPCEL--CPKDDEVAFQDLCPYGHGTVPSLHDT--R 2169
                A N T  +CCC+   GEGWG  C +  CP  +   +Q LCP+G G +    D   R
Sbjct: 1157 DNILARNVTWQECCCTV--GEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLR 1214

Query: 2170 EDVNEC-LESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNP-CGNGT 2227
             DV+EC L    +C +G C+NT   + C C  GY      + C+D DEC+   P C  G 
Sbjct: 1215 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGR 1274

Query: 2228 CTNVIGSFECNCNEGFE-PGPMMNC---------EDINECAQN---PLLCAFRCMNTFGS 2274
            C N +GS+ C C       G    C         +++  C Q     L+C+   ++   +
Sbjct: 1275 CVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQAT 1334

Query: 2275 Y-ECTCPIGYALREDQKMCKDLD 2296
            Y EC C  G A   D  +C   D
Sbjct: 1335 YTECCCLYGEAWGMDCALCPAQD 1357



 Score =  426 bits (1094), Expect = e-118
 Identities = 358/1219 (29%), Positives = 493/1219 (40%), Gaps = 250/1219 (20%)

Query: 214  GPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWG-HPCEMCPAQPQPCRRGFIPNIRTG 272
            G CF ++    C   L G+  T+ +CC   G AWG H C++C  +     R   P     
Sbjct: 250  GYCFRELRGGECASPLPGLR-TQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAP----- 303

Query: 273  ACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG 332
                                       +  CP G ++      CED+DEC+   G C+ G
Sbjct: 304  ---------------------------DGPCPTGFER--VNGSCEDVDECAT-GGRCQHG 333

Query: 333  ECSNTVGSYFCVCPRGYVTSTDGSRCIDQRT-----GMCFSGLVNGRCAQELPGRMTKMQ 387
            EC+NT G Y CVCP G++  +  S CI Q       G CF  L +G C+  +   +TK  
Sbjct: 334  ECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQI 393

Query: 388  CCCEP-GRCWGIGTIPEACPVRGSEEYRRLCMDG--------------LPMGGIPGS--- 429
            CCC   G+ WG G   + CP  GSE +R +C  G               P+G  P     
Sbjct: 394  CCCSRVGKAWGRGC--QLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSL 451

Query: 430  -------AGSRPGGTGGNGFAPSGNGNGYG-------PGGTGFIP-IPGGNGFSPGVGGA 474
                   A SRP      GF P+              PG    +P IP   G  P +  +
Sbjct: 452  SQPRTLPATSRPSA----GFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTG--PEIPES 505

Query: 475  GVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGD-C 533
            G  +G                 +C+ +  +C  GRCI   S Y C C+ G++    G  C
Sbjct: 506  GPSSG-----------------MCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRC 548

Query: 534  IDVDEC--TSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRC 591
            IDVDEC     PC  G C N+PGS+ C C  GF+  P    C+D+DEC +    C  GRC
Sbjct: 549  IDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 608

Query: 592  VNTDGSFQCICNAGFELTTDGKNCVDHDECTTT-NMCLNGMCINEDGSFKCICKPGFVLA 650
             NT GSF C+C AG++    G +C D DECT +  +C  G C N  GSF+C+C  GF   
Sbjct: 609  ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--- 665

Query: 651  PNGRYCT-DVDEC-QTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVD--------- 699
              G  C  DVDEC Q P  C  G C N+ GSF C CP G      G  C D         
Sbjct: 666  -RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPP 724

Query: 700  --THMRSTCYGGIKKGVCVRPFPGAVTKSEC-----------C----CANPDYGFGEPCQ 742
              T+ R     G  + VC   F      SEC           C    C N    F   C+
Sbjct: 725  PCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSF--QCR 782

Query: 743  PCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICA-NGICENLRGSYRCNCNSGYE- 800
             CP+ +     G C+          D++EC+     C  +G C N  GS+RC+C  GY  
Sbjct: 783  TCPSGHHLH-RGRCT----------DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRA 831

Query: 801  PDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINEC-ESN 859
            P      C D++ECL       +G C NT GS++CTC PGY       +C D++EC E +
Sbjct: 832  PSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEED 891

Query: 860  PCVNGACRNNLGSFNCECSPGSKLSSTGLICID----SLKGTCWLNIQDSRCEVNINGAT 915
             C +G C N  GSF C C PG +       C+D      +G      Q  RCE +     
Sbjct: 892  LCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ--RCENSPGSYR 949

Query: 916  LKSECCATLGAAWGSPCE----------------RCE-------LDTACPRGLARIKGVT 952
               +C     A     C+                RCE          AC  G     G  
Sbjct: 950  CVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG 1009

Query: 953  CEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDEC 1012
            C+DV+EC        +  C N  GSF C C +G      GR C+D+         +E E 
Sbjct: 1010 CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDV---------NECET 1060

Query: 1013 IHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPR------GAGF-------A 1059
            +  V G     A C  V  ++   C   P+    E++ +  R       AG        A
Sbjct: 1061 LQGVCGA----ALCENVEGSFLCVCPNSPE----EFDPMTGRCVPPRTSAGTFPGSQPQA 1112

Query: 1060 NRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFAL-----DMEERNCT 1114
                VL  RP    +    + P        +  +GS +  C    A      ++  RN T
Sbjct: 1113 PASPVLPARPPPPPLPRRPSTPR-------QGPVGSGRRECYFDTAAPDACDNILARNVT 1165

Query: 1115 DIDECRISPDLCGSGICVNT-PGSFE------CECFEGY--ESGFMMMKNCMDIDECER- 1164
              + C    +  GSG  +   PG+        C    GY   SG + ++   D+DEC+  
Sbjct: 1166 WQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRR--DVDECQLF 1223

Query: 1165 NPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQ 1224
               +C+ G CVNT   + C C  G+     R +C+D +EC+  +  C  G+CVN +G+Y 
Sbjct: 1224 RDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYH 1283

Query: 1225 CSCNPGYQATPDRQGCTDIDECMIMNG--------GCDTQCT----NSEGSY-ECSCSEG 1271
            C+C P       ++ C   +   + +         G D  C+    + + +Y EC C  G
Sbjct: 1284 CTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYG 1343

Query: 1272 YALMPDGRSC--ADIDECE 1288
             A   D   C   D D+ E
Sbjct: 1344 EAWGMDCALCPAQDSDDFE 1362



 Score =  424 bits (1089), Expect = e-118
 Identities = 299/929 (32%), Positives = 393/929 (42%), Gaps = 135/929 (14%)

Query: 1287 CENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKG 1346
            C+ NP +C  G+C + P  Y C C  GF  S     CIDV+EC      C  G CEN+ G
Sbjct: 512  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 571

Query: 1347 SFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIG--NGI 1404
            SF C C  G+        C DVDEC      CD+   C N PGSF C C  G+    +G 
Sbjct: 572  SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDL-GRCENTPGSFLCVCPAGYQAAPHGA 630

Query: 1405 KCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQ 1464
             C D+DEC+     C   A C N PGS+RC C  GF G      DVDECA+    C  G+
Sbjct: 631  SCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACE-EDVDECAQEPPPCGPGR 688

Query: 1465 CLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNI-CVFGTCNNLPGMFHCICDDGYEL 1523
            C N  G++ C C  GF        CQD+DEC+     C +G C N  G F C+C  G++ 
Sbjct: 689  CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 748

Query: 1524 DRTGGNCTDIDECADPINCVNGLCVNTPGRYECN-CPPDFQLNPTGVGCVDNRVGNCYLK 1582
            +  G  C D+DEC + + C    CVN+PG ++C  CP    L+     C D  V  C   
Sbjct: 749  NTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTD--VDECSSG 804

Query: 1583 FGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPN 1642
              P G      NTE         C C+ G                      P G   RP 
Sbjct: 805  APPCGPHGHCTNTE-----GSFRCSCAPGYR-------------------APSG---RPG 837

Query: 1643 PITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGV 1702
            P      D++EC E       G C+NT GSF C C  GY        C D+DEC +   +
Sbjct: 838  PCA----DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDEC-SEEDL 892

Query: 1703 CGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMC 1762
            C  G C NT G++ CICPP +       +C+D+ +           C    P      +C
Sbjct: 893  CQSGICTNTDGSFECICPPGHRAGPDLASCLDVDE-----------CRERGP-----ALC 936

Query: 1763 CCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEI-PGICAN 1821
                      ++ CE  P      ++ +    PG+      G   D+DEC+E  P IC  
Sbjct: 937  ---------GSQRCENSP----GSYRCVRDCDPGYHAGPE-GTCDDVDECQEYGPEICGA 982

Query: 1822 GVCINQIGSFRCE--CPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECA 1879
              C N  GS+RC   C  G+        C+D+DEC N  + C  +A C N PGS++C C 
Sbjct: 983  QRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNR-SFCGAHAVCQNLPGSFQCLCD 1040

Query: 1880 AGFKLSPNGA-CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNG---------------- 1922
             G++ + +G  CVD NEC  +  VC   LC +++GS+ C+C N                 
Sbjct: 1041 QGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRT 1100

Query: 1923 ----FKASQDQTMCMDVDECERHPCGNGTCKNT-----VGSYNCLCYPGFELTHNNDCLD 1973
                F  SQ Q     V      P       +T     VGS    CY  F+    + C +
Sbjct: 1101 SAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECY--FDTAAPDACDN 1158

Query: 1974 I-------DEC----SSFFGQVCRNGRC-FNEIGSFKCLCNEGYE-LTPDGKNCI--DTN 2018
            I        EC       +G  CR  +C   E   ++ LC  G   L P G   +  D +
Sbjct: 1159 ILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVD 1218

Query: 2019 ECVALPGS-CSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPNICLFGSCTNT 2075
            EC       C  G C N    + C C  GY   ++   CID +EC ++   C  G C NT
Sbjct: 1219 ECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNT 1278

Query: 2076 PGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNF-----ENGK---CSVPKA-FNTTKAKC 2126
             G + C C P  VL  + RRC          N      E G    CS P+     T  +C
Sbjct: 1279 VGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTEC 1338

Query: 2127 CCSKMPGEGWGDPCELCPKDDEVAFQDLC 2155
            CC  + GE WG  C LCP  D   F+ LC
Sbjct: 1339 CC--LYGEAWGMDCALCPAQDSDDFEALC 1365



 Score =  418 bits (1075), Expect = e-116
 Identities = 350/1212 (28%), Positives = 480/1212 (39%), Gaps = 267/1212 (22%)

Query: 171  IGTYCGQPVCENG-----CQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMC 225
            I  + G  + E+G     CQ   +  GP RC          C+  +R  P  T+      
Sbjct: 494  IPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRC----- 548

Query: 226  QGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIP 284
               +    C +       GR     CE  P   +  C  GF    R   C DVDEC  +P
Sbjct: 549  ---IDVDECRRVPPPCAPGR-----CENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVP 600

Query: 285  GICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCV 344
              C  G C NT GSF C CPAG++ +     C+D+DEC+  PG+C  G C N  GS+ CV
Sbjct: 601  PPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCV 660

Query: 345  CPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWG-IGTIPE 403
            CP G+     GS C +              CAQE P         C PGRC    G+   
Sbjct: 661  CPAGF----RGSACEED----------VDECAQEPPP--------CGPGRCDNTAGSFHC 698

Query: 404  ACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPG 463
            ACP        R    G P   +   A S P  T G      G+     P          
Sbjct: 699  ACPAG-----FRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCP---------- 743

Query: 464  GNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCE-CN 522
              GF P   G+                  + +D C++H   C    C+ +  S++C  C 
Sbjct: 744  -MGFQPNTAGSEC----------------EDVDECENHL-ACPGQECVNSPGSFQCRTCP 785

Query: 523  MGYKQDANGDCIDVDECTSN--PC-TNGDCVNTPGSYYCKCHAGFQRTPTKQ--ACIDID 577
             G+     G C DVDEC+S   PC  +G C NT GS+ C C  G+ R P+ +   C D++
Sbjct: 786  SGHHLH-RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGY-RAPSGRPGPCADVN 843

Query: 578  ECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDG 637
            EC++      +G C+NTDGSF C C  G+     G +C+D DEC+  ++C +G+C N DG
Sbjct: 844  ECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDG 903

Query: 638  SFKCICKPGFVLAPNGRYCTDVDECQT--PGICMNGHCINSEGSFRC--DCPPGLAVGMD 693
            SF+CIC PG    P+   C DVDEC+   P +C +  C NS GS+RC  DC PG   G +
Sbjct: 904  SFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPE 963

Query: 694  GRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFH 753
            G  C D                           EC    P+    + C+  P   S    
Sbjct: 964  G-TCDDV-------------------------DECQEYGPEICGAQRCENTP--GSYRCT 995

Query: 754  GLCSSGVGITVDG--RDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDI 811
              C  G   T  G  +D++EC       A+ +C+NL GS++C C+ GYE    GR+C+D+
Sbjct: 996  PACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDV 1055

Query: 812  DECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGAC---RN 868
            +EC   + +C   LC N  GS+ C CP               N  E    + G C   R 
Sbjct: 1056 NECETLQGVCGAALCENVEGSFLCVCP---------------NSPEEFDPMTGRCVPPRT 1100

Query: 869  NLGSF-----NCECSP-----------GSKLSSTGLICIDSLKGTCWLN-IQDSRCEVNI 911
            + G+F         SP             + S+     + S +  C+ +      C+  +
Sbjct: 1101 SAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNIL 1160

Query: 912  NGATLKSECCATLGAAWGSPC--------ERCELDTACPRG---LARIKGVTC-EDVNEC 959
                   ECC T+G  WGS C        E  E  + CP G   LA    ++   DV+EC
Sbjct: 1161 ARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDEC 1220

Query: 960  EVF------PGVCPN-------------------------------------GRCVNSKG 976
            ++F       GVC N                                     GRCVN+ G
Sbjct: 1221 QLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVG 1280

Query: 977  SFHCECPEGLTLDGTGRVC-------LDIRMEQCYLKWDED-ECIHP-VPGKFRMDACCC 1027
            S+HC C   L LDG+ R C       LD  +  C+ +   D  C HP +  +     CCC
Sbjct: 1281 SYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCC 1340

Query: 1028 AVGAAWGTECEECPKPGTKEYETLC----------PRGAGFA-------NRGDVLTGRPF 1070
              G AWG +C  CP   + ++E LC          PR  GF        + G    G P+
Sbjct: 1341 LYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPY 1400

Query: 1071 YKDINECKAFP-------------GMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDID 1117
              ++    A P                 YG  R  +  F+   + G      E       
Sbjct: 1401 GPELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFE---DDGGPYGESEAPAPPGP 1457

Query: 1118 ECR---ISPDLCGSGICVNTP---GSFECECFEGYESGFMMMKNCMDIDECERNPLLCRG 1171
              R    S D   S      P   GS+     E YE   +  + C  +D        C  
Sbjct: 1458 GTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEE--LEAEECGILDG-------CTN 1508

Query: 1172 GTCVNTEGSFQCDCPLGHELSPSREDCVDINEC---SLSDNLCRNGKCVNMIGTYQCSCN 1228
            G CV     F C C  G+ L  +R  CVDINEC     +  LC N +C+N  G+++C C 
Sbjct: 1509 GRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICR 1568

Query: 1229 PGYQATPDRQGC 1240
            PG+  T     C
Sbjct: 1569 PGFAPTHQPHHC 1580



 Score =  392 bits (1007), Expect = e-108
 Identities = 271/841 (32%), Positives = 363/841 (43%), Gaps = 144/841 (17%)

Query: 1983 QVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCI 2042
            QVC  GRC +    + C C+ G+ L+P G  CID +EC  +P  C+PG C+N  GSFRC+
Sbjct: 517  QVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCV 576

Query: 2043 CPPGYEV--KSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR 2100
            C PG+    ++  C+D++EC   P  C  G C NTPG F C+CP G+  + +G  C D  
Sbjct: 577  CGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVD 636

Query: 2101 QSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYG-H 2159
            +                          C++ PG      C+  P     +F+ +CP G  
Sbjct: 637  E--------------------------CTQSPGLCGRGACKNLPG----SFRCVCPAGFR 666

Query: 2160 GTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSI 2219
            G+        EDV+EC + P  C  G+C NT GSF C CP G+     G  C D DEC+ 
Sbjct: 667  GSA-----CEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 721

Query: 2220 GNP-CGNGTCTNVIGSFECNCNEGFEPGPM-MNCEDINECAQNPLLCAFR-CMNTFGSYE 2276
              P C  G C N  GSF+C C  GF+P      CED++EC +N L C  + C+N+ GS++
Sbjct: 722  SPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC-ENHLACPGQECVNSPGSFQ 780

Query: 2277 C-TCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEG 2335
            C TCP G+ L   +  C D+DEC+ G   C   G  C N  G+F C C PG  R P G  
Sbjct: 781  CRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGH-CTNTEGSFRCSCAPGY-RAPSGRP 836

Query: 2336 --CVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQT 2393
              C D NEC        +G C+N  GS+ C C  G++    G  CLD  +  C  E L  
Sbjct: 837  GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDE--CSEEDL-- 892

Query: 2394 ICQMASSSRNLVTKSECCCDGGRGWGHQCELC--------------------PLPGTAQY 2433
             CQ    + N     EC C  G   G     C                      PG+ + 
Sbjct: 893  -CQSGICT-NTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRC 950

Query: 2434 KKICPHGPGYTTDGR--DIDECKVM-PNLCTNGQCINTMGSFRCF--CKVGYTTDISGTS 2488
             + C  G     +G   D+DEC+   P +C   +C NT GS+RC   C  GY     G  
Sbjct: 951  VRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-G 1009

Query: 2489 CIDLDEC-SQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNC-QFL 2546
            C D+DEC ++S    + +C+N  GS+QC C +GY    DG+ C D++EC+T Q  C   L
Sbjct: 1010 CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAAL 1069

Query: 2547 CVNTLGGFTCKCPPG---FTQHHTACIDNNEC-----GSQPSLCGAKGICQNTP------ 2592
            C N  G F C CP     F      C+          GSQP    +  +    P      
Sbjct: 1070 CENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPR 1129

Query: 2593 ----------GSFSCECQRGFSLDATGLNCEDVDECDG----NHRCQHGCQNILGGYRCG 2638
                      GS   EC           +    D CD     N   Q  C  +  G+  G
Sbjct: 1130 RPSTPRQGPVGSGRRECY---------FDTAAPDACDNILARNVTWQECCCTVGEGWGSG 1180

Query: 2639 CP-------------------QGYIQ---HYQWNQCVDENECSNPNACGSASCYNTLGSY 2676
            C                    +GY+         + VDE +      C S  C NT   Y
Sbjct: 1181 CRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGY 1240

Query: 2677 KCACPSGFSFDQFSSACHDVNECSSSKNPCNYG-CSNTEGGYLCGC-PPGYYRVGQGHCV 2734
             C C +G+ +      C D +EC+  +  C  G C NT G Y C C PP      Q  CV
Sbjct: 1241 SCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1300

Query: 2735 S 2735
            S
Sbjct: 1301 S 1301



 Score =  377 bits (969), Expect = e-104
 Identities = 281/866 (32%), Positives = 378/866 (43%), Gaps = 143/866 (16%)

Query: 1896 CLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECER--HPCGNGTCKNTVG 1953
            C   P VC  G C+     Y C C +GF+ S   T C+DVDEC R   PC  G C+N+ G
Sbjct: 512  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 571

Query: 1954 SYNCLCYPGFEL-THNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGK 2012
            S+ C+C PGF       +CLD+DEC       C  GRC N  GSF C+C  GY+  P G 
Sbjct: 572  SFRCVCGPGFRAGPRAAECLDVDECHRV-PPPCDLGRCENTPGSFLCVCPAGYQAAPHGA 630

Query: 2013 NCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCI-DINECDEDPNICLFGS 2071
            +C D +EC   PG C  G C+NL GSFRC+CP G+  +   C  D++EC ++P  C  G 
Sbjct: 631  SCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--RGSACEEDVDECAQEPPPCGPGR 688

Query: 2072 CTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKM 2131
            C NT G F C CP GF     G  C D  +                          C++ 
Sbjct: 689  CDNTAGSFHCACPAGFRSRGPGAPCQDVDE--------------------------CARS 722

Query: 2132 PGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTD 2191
            P       CE    + E +FQ +CP G     +  +  EDV+EC E+   C   +C+N+ 
Sbjct: 723  PPPCTYGRCE----NTEGSFQCVCPMGFQPNTAGSEC-EDVDEC-ENHLACPGQECVNSP 776

Query: 2192 GSFRCE-CPMGYNLDYTGVRCVDTDECSIGNP-CG-NGTCTNVIGSFECNCNEGFE---- 2244
            GSF+C  CP G++L + G RC D DECS G P CG +G CTN  GSF C+C  G+     
Sbjct: 777  GSFQCRTCPSGHHL-HRG-RCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSG 834

Query: 2245 -PGPMMNCEDINECAQNPLLCAF-RCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGL 2302
             PGP   C D+NEC +         C+NT GS+ CTC  GY        C D+DEC+E  
Sbjct: 835  RPGP---CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEE- 890

Query: 2303 HDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTK-PGICENGRCVNIIGSY 2361
              C+S   +C N  G+F CICPPG    PD   C+D +ECR + P +C + RC N  GSY
Sbjct: 891  DLCQSG--ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSY 948

Query: 2362 RC--ECNEGFQSSSSGT-----ECLDNRQGLCFAEVLQTI-----CQMASSSRNLVTKSE 2409
            RC  +C+ G+ +   GT     EC +    +C A+  +       C  A       T   
Sbjct: 949  RCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG 1008

Query: 2410 CCCD----GGRGWGHQCELCP-LPGTAQYKKICPHGPGYTTDGR---DIDECKVMPN--- 2458
             C D      R +     +C  LPG+ Q   +C  G     DGR   D++EC+ +     
Sbjct: 1009 GCQDVDECRNRSFCGAHAVCQNLPGSFQC--LCDQGYEGARDGRHCVDVNECETLQGVCG 1066

Query: 2459 --LCTNGQ------CINTMGSF-----RCF---CKVGY---------------------- 2480
              LC N +      C N+   F     RC       G                       
Sbjct: 1067 AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPP 1126

Query: 2481 -----TTDISGTSCIDLDEC---SQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKD 2532
                 +T   G       EC   + +P  C+ I        +C C  G   +  G  C+ 
Sbjct: 1127 LPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVG---EGWGSGCR- 1182

Query: 2533 LDECQ-TKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNT 2591
            + +C  T+    Q LC +  G      P G         D +EC          G+C NT
Sbjct: 1183 IQQCPGTETAEYQSLCPHGRGYLA---PSGDLSLRR---DVDECQLFRDQVCKSGVCVNT 1236

Query: 2592 PGSFSCECQRGFSLDATGLNCEDVDEC-DGNHRCQHG-CQNILGGYRCGCPQGYIQHYQW 2649
               +SC C  G+      L C D DEC D    C+ G C N +G Y C C    +     
Sbjct: 1237 APGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQ 1296

Query: 2650 NQCVDENECSNPNACGSASCYNTLGS 2675
             +CV     S  +  G   C+  +G+
Sbjct: 1297 RRCVSNESQSLDDNLG--VCWQEVGA 1320



 Score =  372 bits (956), Expect = e-102
 Identities = 274/835 (32%), Positives = 375/835 (44%), Gaps = 104/835 (12%)

Query: 1959 CYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTN 2018
            C  GFE   N  C D+DEC++  G  C++G C N  G + C+C +G+ L     +CI  +
Sbjct: 307  CPTGFERV-NGSCEDVDECAT--GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 363

Query: 2019 EC---------VALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICL- 2068
                       V   G CS    +N+     C C    +     C           +C  
Sbjct: 364  VISEAKGPCFRVLRDGGCSLPILRNITKQI-CCCSRVGKAWGRGC----------QLCPP 412

Query: 2069 FGSCTNTPGGFQCLCP--PGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKC 2126
            FGS      GF+ +CP  PG+  S +  R ++TR          G+   P+   +     
Sbjct: 413  FGS-----EGFREICPAGPGYHYSASDLR-YNTRPL--------GQ-EPPRVSLSQPRTL 457

Query: 2127 CCSKMPGEGWGDPCELCPKDD---------EVAFQDLCPYGHGTVPSLHDTREDVNECLE 2177
              +  P  G+     L P+ +         E+    +  +   T P + ++      C  
Sbjct: 458  PATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAW---TGPEIPESGPSSGMCQR 514

Query: 2178 SPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDEC-SIGNPCGNGTCTNVIGSFE 2236
            +P +C  G+CI+    + C C  G+ L   G RC+D DEC  +  PC  G C N  GSF 
Sbjct: 515  NPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFR 574

Query: 2237 CNCNEGFEPGP-MMNCEDINECAQNPLLCAF-RCMNTFGSYECTCPIGYALREDQKMCKD 2294
            C C  GF  GP    C D++EC + P  C   RC NT GS+ C CP GY        C+D
Sbjct: 575  CVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQD 634

Query: 2295 LDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECRTKPGICENGR 2353
            +DEC +    C  RG  CKNL G+F C+CP G      G  C  D +EC  +P  C  GR
Sbjct: 635  VDECTQSPGLC-GRG-ACKNLPGSFRCVCPAGFR----GSACEEDVDECAQEPPPCGPGR 688

Query: 2354 CVNIIGSYRCECNEGFQSSSSGTECLDNRQ----------GLC--FAEVLQTICQMASSS 2401
            C N  GS+ C C  GF+S   G  C D  +          G C       Q +C M    
Sbjct: 689  CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 748

Query: 2402 RNLVTKSECC--CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR--DIDECKV-M 2456
                ++ E    C+       Q E    PG+ Q  + CP G  +   GR  D+DEC    
Sbjct: 749  NTAGSECEDVDECENHLACPGQ-ECVNSPGSFQC-RTCPSG-HHLHRGRCTDVDECSSGA 805

Query: 2457 PNLCTNGQCINTMGSFRCFCKVGYTTDISGT--SCIDLDECSQSPKPCNY-ICKNTEGSY 2513
            P    +G C NT GSFRC C  GY    SG    C D++EC +      +  C NT+GS+
Sbjct: 806  PPCGPHGHCTNTEGSFRCSCAPGYRAP-SGRPGPCADVNECLEGDFCFPHGECLNTDGSF 864

Query: 2514 QCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFT--QHHTACID 2571
             C+C  GY     G +C D+DEC  +      +C NT G F C CPPG        +C+D
Sbjct: 865  ACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLD 924

Query: 2572 NNECGSQ-PSLCGAKGICQNTPGSFSC--ECQRGFSLDATGLNCEDVDECD--GNHRC-Q 2625
             +EC  + P+LCG++  C+N+PGS+ C  +C  G+     G  C+DVDEC   G   C  
Sbjct: 925  VDECRERGPALCGSQR-CENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGA 982

Query: 2626 HGCQNILGGYRC--GCPQGYIQHYQWNQCVDENECSNPNACGS-ASCYNTLGSYKCACPS 2682
              C+N  G YRC   C  GY Q      C D +EC N + CG+ A C N  GS++C C  
Sbjct: 983  QRCENTPGSYRCTPACDPGY-QPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQ 1041

Query: 2683 GFSFDQFSSACHDVNECSSSKNPCNYG-CSNTEGGYLCGCP--PGYYRVGQGHCV 2734
            G+   +    C DVNEC + +  C    C N EG +LC CP  P  +    G CV
Sbjct: 1042 GYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1096



 Score =  315 bits (806), Expect = 5e-85
 Identities = 299/1019 (29%), Positives = 385/1019 (37%), Gaps = 251/1019 (24%)

Query: 29   QPQPPPPKPPRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLRGPNV 88
            +P+P P   PRP P           S   +  PE  E G   +S + +R  Q  + GP  
Sbjct: 474  EPRPEPRPDPRPGP------ELPLPSIPAWTGPEIPESGP--SSGMCQRNPQ--VCGPGR 523

Query: 89   CGSRFHSYCC---PGWKTLPGGNQCI-------VP------ICRNS-------CGDGFCS 125
            C SR   Y C    G++  P G +CI       VP       C NS       CG GF +
Sbjct: 524  CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 583

Query: 126  RPNMC-------------TCSSGQISSTCGSKSIQQCSV---RCMNGGTCAD-DHCQCQK 168
             P                 C  G+  +T GS  +  C        +G +C D D C    
Sbjct: 584  GPRAAECLDVDECHRVPPPCDLGRCENTPGS-FLCVCPAGYQAAPHGASCQDVDECTQSP 642

Query: 169  GYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQ 228
            G     CG+  C+N         G  RC C  GF G  CE D     C  +         
Sbjct: 643  G----LCGRGACKN-------LPGSFRCVCPAGFRGSACEED--VDECAQEPP------- 682

Query: 229  LTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQ 288
                 C    C  T G      C  CPA       GF        CQDVDEC   P  C 
Sbjct: 683  ----PCGPGRCDNTAG---SFHC-ACPA-------GFRSRGPGAPCQDVDECARSPPPCT 727

Query: 289  GGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFC-VCPR 347
             G C NT GSF+C CP G + +    +CED+DEC      C   EC N+ GS+ C  CP 
Sbjct: 728  YGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLA-CPGQECVNSPGSFQCRTCPS 786

Query: 348  GYVTSTDGSRCIDQRTGMCFSGL----VNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPE 403
            G+       RC D     C SG      +G C           +C C PG          
Sbjct: 787  GH--HLHRGRCTD--VDECSSGAPPCGPHGHCT----NTEGSFRCSCAPG---------- 828

Query: 404  ACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPG 463
                     YR              +   RPG        P  + N    G   F   P 
Sbjct: 829  ---------YR--------------APSGRPG--------PCADVNECLEGDFCF---PH 854

Query: 464  GNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNM 523
            G   +     A   A G  P   G + L+  +D C    +LC +G C  T  S+ C C  
Sbjct: 855  GECLNTDGSFACTCAPGYRPGPRGASCLD--VDECSEE-DLCQSGICTNTDGSFECICPP 911

Query: 524  GYKQDAN-GDCIDVDECTSNP---CTNGDCVNTPGSYYC--KCHAGFQRTPTKQACIDID 577
            G++   +   C+DVDEC       C +  C N+PGSY C   C  G+   P +  C D+D
Sbjct: 912  GHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGP-EGTCDDVD 970

Query: 578  ECIQNG-VLCKNGRCVNTDGSFQC--ICNAGFELTTDGKNCVDHDECTTTNMC-LNGMCI 633
            EC + G  +C   RC NT GS++C   C+ G++  T G  C D DEC   + C  + +C 
Sbjct: 971  ECQEYGPEICGAQRCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRSFCGAHAVCQ 1029

Query: 634  NEDGSFKCICKPGFVLAPNGRYCTDVDECQT-PGICMNGHCINSEGSFRCDCP--PGLAV 690
            N  GSF+C+C  G+  A +GR+C DV+EC+T  G+C    C N EGSF C CP  P    
Sbjct: 1030 NLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFD 1089

Query: 691  GMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGA---------------------------- 722
             M GR CV     +  + G +      P   A                            
Sbjct: 1090 PMTGR-CVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYF 1148

Query: 723  ---------------VTKSECCCANPDYGFGEPC--QPCPAKNSAEFHGLCSSGVGITVD 765
                           VT  ECCC   + G+G  C  Q CP   +AE+  LC  G G    
Sbjct: 1149 DTAAPDACDNILARNVTWQECCCTVGE-GWGSGCRIQQCPGTETAEYQSLCPHGRGYLAP 1207

Query: 766  G------RDINECALDPD-ICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNR 818
                   RD++EC L  D +C +G+C N    Y C C++GY        CID DEC    
Sbjct: 1208 SGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEE 1267

Query: 819  LLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECS 878
              C+ G C NT GSY CTC P  V       C   NE +S                    
Sbjct: 1268 PACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQS-------------------- 1306

Query: 879  PGSKLSSTGLICIDSLKGTCWLNI-QDSRC-EVNINGATLKSECCATLGAAWGSPCERC 935
                        +D   G CW  +  D  C    ++     +ECC   G AWG  C  C
Sbjct: 1307 ------------LDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALC 1353



 Score =  310 bits (795), Expect = 1e-83
 Identities = 184/517 (35%), Positives = 244/517 (47%), Gaps = 59/517 (11%)

Query: 2257 CAQNPLLCA-FRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNL 2315
            C +NP +C   RC++    Y C C  G+ L      C D+DEC      C      C+N 
Sbjct: 512  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPG--RCENS 569

Query: 2316 IGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSG 2375
             G+F C+C PG    P    C+D +EC   P  C+ GRC N  GS+ C C  G+Q++  G
Sbjct: 570  PGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHG 629

Query: 2376 TECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKK 2435
              C D  +                      T+S   C  GRG    C+   LPG+  ++ 
Sbjct: 630  ASCQDVDE---------------------CTQSPGLC--GRG---ACK--NLPGS--FRC 659

Query: 2436 ICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDEC 2495
            +CP G   +    D+DEC   P  C  G+C NT GSF C C  G+ +   G  C D+DEC
Sbjct: 660  VCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDEC 719

Query: 2496 SQSPKPCNY-ICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGF 2554
            ++SP PC Y  C+NTEGS+QC CP G+     G  C+D+DEC+         CVN+ G F
Sbjct: 720  ARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSF 779

Query: 2555 TCK-CPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLN-C 2612
             C+ CP G   H   C D +EC S    CG  G C NT GSF C C  G+   +     C
Sbjct: 780  QCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPC 839

Query: 2613 EDVDEC-DGNHRCQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCY 2670
             DV+EC +G+    HG C N  G + C C  GY    +   C+D +ECS  + C S  C 
Sbjct: 840  ADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICT 899

Query: 2671 NTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYG---CSNTEGGYLC--GCPPGY 2725
            NT GS++C CP G       ++C DV+EC   + P   G   C N+ G Y C   C PGY
Sbjct: 900  NTDGSFECICPPGHRAGPDLASCLDVDEC-RERGPALCGSQRCENSPGSYRCVRDCDPGY 958

Query: 2726 YRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEAC 2762
            +   +G C                +VDE     PE C
Sbjct: 959  HAGPEGTC---------------DDVDECQEYGPEIC 980



 Score =  235 bits (599), Expect = 5e-61
 Identities = 168/517 (32%), Positives = 229/517 (44%), Gaps = 81/517 (15%)

Query: 2268 CMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI----- 2322
            C       EC  P+   LR  +  C+     A G+HDC+    +C   +G    +     
Sbjct: 252  CFRELRGGECASPLP-GLRTQEVCCRGAG-LAWGVHDCQ----LCSERLGNSERVSAPDG 305

Query: 2323 -CPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDN 2381
             CP G  R      C D +EC T  G C++G C N  G Y C C +GF   SS + C+  
Sbjct: 306  PCPTGFERV--NGSCEDVDECATG-GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQ 362

Query: 2382 R-----QGLCFAEVLQTICQMASSSRNLVTKSECCCDG-GRGWGHQCELCPLPGTAQYKK 2435
                  +G CF  +    C +    RN +TK  CCC   G+ WG  C+LCP  G+  +++
Sbjct: 363  HVISEAKGPCFRVLRDGGCSLPIL-RN-ITKQICCCSRVGKAWGRGCQLCPPFGSEGFRE 420

Query: 2436 ICPHGPGYTTDGRD----------------IDECKVMPNLCTNGQCINTMGSFRCFCKVG 2479
            ICP GPGY     D                + + + +P   T+      + + R   +  
Sbjct: 421  ICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLP--ATSRPSAGFLPTHRLEPRPE 478

Query: 2480 YTTD-----------ISGTSCIDLDECSQSPKPCN---YICKNTEGSYQC-SCPRGYV-- 2522
               D           I   +  ++ E   S   C     +C    G  +C S P GY   
Sbjct: 479  PRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVC----GPGRCISRPSGYTCA 534

Query: 2523 ------LQEDGKTCKDLDECQTKQHNC-QFLCVNTLGGFTCKCPPGFTQHHTA--CIDNN 2573
                  L   G  C D+DEC+     C    C N+ G F C C PGF     A  C+D +
Sbjct: 535  CDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVD 594

Query: 2574 ECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC-DGNHRCQHG-CQNI 2631
            EC   P  C   G C+NTPGSF C C  G+     G +C+DVDEC      C  G C+N+
Sbjct: 595  ECHRVPPPCDL-GRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNL 653

Query: 2632 LGGYRCGCPQGYIQHYQWNQC-VDENECS-NPNACGSASCYNTLGSYKCACPSGFSFDQF 2689
             G +RC CP G    ++ + C  D +EC+  P  CG   C NT GS+ CACP+GF     
Sbjct: 654  PGSFRCVCPAG----FRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGP 709

Query: 2690 SSACHDVNECSSSKNPCNYG-CSNTEGGYLCGCPPGY 2725
             + C DV+EC+ S  PC YG C NTEG + C CP G+
Sbjct: 710  GAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGF 746



 Score =  129 bits (324), Expect = 4e-29
 Identities = 108/389 (27%), Positives = 152/389 (39%), Gaps = 50/389 (12%)

Query: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWG-HQCELCPLPGTAQYKKICPHGPG 2442
            G CF E+    C  AS    L T+  CC   G  WG H C+LC        +   P GP 
Sbjct: 250  GYCFRELRGGEC--ASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPC 307

Query: 2443 YTTDGR------DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECS 2496
             T   R      D+DEC      C +G+C NT G + C C  G+  D S +SCI     S
Sbjct: 308  PTGFERVNGSCEDVDECAT-GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVIS 366

Query: 2497 QSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTC 2556
            ++  PC  + ++      CS P    + +    C  + +   +   CQ        GF  
Sbjct: 367  EAKGPCFRVLRDG----GCSLPILRNITKQICCCSRVGKAWGR--GCQLCPPFGSEGFRE 420

Query: 2557 KCPPGFTQHHTAC---IDNNECGSQP---SLCGAKGI-CQNTPGSFSCECQR-------- 2601
             CP G   H++A     +    G +P   SL   + +   + P +      R        
Sbjct: 421  ICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPR 480

Query: 2602 -----GFSLDATGLNC----EDVDECDGNHRCQHG--------CQNILGGYRCGCPQGYI 2644
                 G  L    +      E  +    +  CQ          C +   GY C C  G+ 
Sbjct: 481  PDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFR 540

Query: 2645 QHYQWNQCVDENECSN-PNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSK 2703
               Q  +C+D +EC   P  C    C N+ GS++C C  GF     ++ C DV+EC    
Sbjct: 541  LSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVP 600

Query: 2704 NPCNYG-CSNTEGGYLCGCPPGYYRVGQG 2731
             PC+ G C NT G +LC CP GY     G
Sbjct: 601  PPCDLGRCENTPGSFLCVCPAGYQAAPHG 629



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 35/99 (35%), Positives = 51/99 (51%), Gaps = 11/99 (11%)

Query: 1262 GSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMK 1321
            GSY  S +E Y  + +   C  +D C N       G+C  +P  + C C+DG+   M   
Sbjct: 1482 GSYAGSLAEPYEEL-EAEECGILDGCTN-------GRCVRVPEGFTCRCFDGYRLDMTRM 1533

Query: 1322 TCIDVNECD---LNSNICMFGECENTKGSFICHCQLGYS 1357
             C+D+NECD     S +C+   C NT GSF C C+ G++
Sbjct: 1534 ACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFA 1572



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 33/77 (42%), Positives = 41/77 (53%), Gaps = 6/77 (7%)

Query: 1491 DIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDEC-----ADPINCVNG 1545
            + +EC   + C  G C  +P  F C C DGY LD T   C DI+EC     A P+ CVN 
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL-CVNA 1554

Query: 1546 LCVNTPGRYECNCPPDF 1562
             C+NT G + C C P F
Sbjct: 1555 RCLNTDGSFRCICRPGF 1571



 Score = 66.2 bits (160), Expect = 4e-10
 Identities = 37/96 (38%), Positives = 45/96 (46%), Gaps = 7/96 (7%)

Query: 2156 PYGHGTVPSLHDTREDVN--ECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVD 2213
            P G     SL +  E++   EC    G C+NG+C+     F C C  GY LD T + CVD
Sbjct: 1479 PEGGSYAGSLAEPYEELEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1537

Query: 2214 TDECSIGNP----CGNGTCTNVIGSFECNCNEGFEP 2245
             +EC         C N  C N  GSF C C  GF P
Sbjct: 1538 INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP 1573



 Score = 65.9 bits (159), Expect = 6e-10
 Identities = 30/93 (32%), Positives = 44/93 (47%), Gaps = 4/93 (4%)

Query: 616  VDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQ----TPGICMNG 671
            ++ +EC   + C NG C+     F C C  G+ L      C D++EC        +C+N 
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 672  HCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRS 704
             C+N++GSFRC C PG A       C     R+
Sbjct: 1555 RCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA 1587



 Score = 65.5 bits (158), Expect = 7e-10
 Identities = 33/91 (36%), Positives = 44/91 (48%), Gaps = 6/91 (6%)

Query: 2015 IDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPN---ICLF 2069
            ++  EC  L G C+ G C  +   F C C  GY +      C+DINECDE      +C+ 
Sbjct: 1495 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1553

Query: 2070 GSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR 2100
              C NT G F+C+C PGF  +     C   R
Sbjct: 1554 ARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1584



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 33/79 (41%), Positives = 39/79 (49%), Gaps = 5/79 (6%)

Query: 1972 LDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNEC---VALPGSCS 2028
            L+ +EC    G  C NGRC      F C C +GY L      C+D NEC    A    C 
Sbjct: 1495 LEAEECGILDG--CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV 1552

Query: 2029 PGTCQNLEGSFRCICPPGY 2047
               C N +GSFRCIC PG+
Sbjct: 1553 NARCLNTDGSFRCICRPGF 1571



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 28/77 (36%), Positives = 45/77 (58%), Gaps = 5/77 (6%)

Query: 2449 DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQ----SPKPCNY 2504
            + +EC ++   CTNG+C+     F C C  GY  D++  +C+D++EC +    SP   N 
Sbjct: 1496 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 2505 ICKNTEGSYQCSCPRGY 2521
             C NT+GS++C C  G+
Sbjct: 1555 RCLNTDGSFRCICRPGF 1571



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 44/142 (30%), Positives = 64/142 (45%), Gaps = 16/142 (11%)

Query: 2103 FCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWG-DPCELCPK----DDEVAFQD-LCP 2156
            +CF     G+C+ P     T+  CC  +  G  WG   C+LC +     + V+  D  CP
Sbjct: 251  YCFRELRGGECASPLPGLRTQEVCC--RGAGLAWGVHDCQLCSERLGNSERVSAPDGPCP 308

Query: 2157 YGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDE 2216
             G   V   + + EDV+EC    G C +G+C NT G + C CP G+ LD +   C+    
Sbjct: 309  TGFERV---NGSCEDVDECATG-GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV 364

Query: 2217 CSIGNPCGNGTCTNVIGSFECN 2238
             S       G C  V+    C+
Sbjct: 365  ISE----AKGPCFRVLRDGGCS 382



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 33/86 (38%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 2212 VDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPG-PMMNCEDINEC----AQNPLLCAF 2266
            ++ +EC I + C NG C  V   F C C +G+      M C DINEC    A +PL    
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 2267 RCMNTFGSYECTCPIGYALREDQKMC 2292
            RC+NT GS+ C C  G+A       C
Sbjct: 1555 RCLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 35/91 (38%), Positives = 47/91 (51%), Gaps = 12/91 (13%)

Query: 1115 DIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPL---LCRG 1171
            + +EC I  D C +G CV  P  F C CF+GY      M  C+DI+EC+       LC  
Sbjct: 1496 EAEECGIL-DGCTNGRCVRVPEGFTCRCFDGYRLDMTRMA-CVDINECDEAEAASPLCVN 1553

Query: 1172 GTCVNTEGSFQCDCPLG-------HELSPSR 1195
              C+NT+GSF+C C  G       H  +P+R
Sbjct: 1554 ARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1584



 Score = 63.2 bits (152), Expect = 4e-09
 Identities = 28/82 (34%), Positives = 45/82 (54%), Gaps = 6/82 (7%)

Query: 1891 VDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHP-----CGN 1945
            ++  EC  I + C++G CV +   + C C +G++    +  C+D++EC+        C N
Sbjct: 1495 LEAEEC-GILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1553

Query: 1946 GTCKNTVGSYNCLCYPGFELTH 1967
              C NT GS+ C+C PGF  TH
Sbjct: 1554 ARCLNTDGSFRCICRPGFAPTH 1575



 Score = 62.4 bits (150), Expect = 6e-09
 Identities = 32/90 (35%), Positives = 43/90 (47%), Gaps = 13/90 (14%)

Query: 1405 KCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGD--GFTCSDVDECAEN---INL 1459
            +C  LD C+NG        +CV  P  + C C +G+  D     C D++EC E      L
Sbjct: 1499 ECGILDGCTNG--------RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL 1550

Query: 1460 CENGQCLNVPGAYRCECEMGFTPASDSRSC 1489
            C N +CLN  G++RC C  GF P      C
Sbjct: 1551 CVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 5/88 (5%)

Query: 1199 VDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGG----CD 1254
            ++  EC + D  C NG+CV +   + C C  GY+    R  C DI+EC           +
Sbjct: 1495 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1553

Query: 1255 TQCTNSEGSYECSCSEGYALMPDGRSCA 1282
             +C N++GS+ C C  G+A       CA
Sbjct: 1554 ARCLNTDGSFRCICRPGFAPTHQPHHCA 1581



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 28/90 (31%), Positives = 40/90 (44%), Gaps = 4/90 (4%)

Query: 276  DVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDEC---SIIPGICETG 332
            + +EC  + G C  G C+     F CRC  G++   T   C DI+EC        +C   
Sbjct: 1496 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 333  ECSNTVGSYFCVCPRGYVTSTDGSRCIDQR 362
             C NT GS+ C+C  G+  +     C   R
Sbjct: 1555 RCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1584



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 31/90 (34%), Positives = 41/90 (45%), Gaps = 4/90 (4%)

Query: 1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDEC---FAHPGVCGPG 1706
            + +EC  L G C  G C+     F C C  GY L      C DI+EC    A   +C   
Sbjct: 1496 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 1707 TCYNTLGNYTCICPPEYMQVNGGHNCMDMR 1736
             C NT G++ CIC P +   +  H+C   R
Sbjct: 1555 RCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1584



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 4/86 (4%)

Query: 1933 MDVDECE-RHPCGNGTCKNTVGSYNCLCYPGFELTHNN-DCLDIDEC--SSFFGQVCRNG 1988
            ++ +EC     C NG C      + C C+ G+ L      C+DI+EC  +     +C N 
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 1989 RCFNEIGSFKCLCNEGYELTPDGKNC 2014
            RC N  GSF+C+C  G+  T    +C
Sbjct: 1555 RCLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 29/79 (36%), Positives = 42/79 (53%), Gaps = 5/79 (6%)

Query: 1807 VDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGD---NLCQR 1863
            ++ +EC  + G C NG C+     F C C  G+  +   + C DI+EC   +    LC  
Sbjct: 1495 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV- 1552

Query: 1864 NADCINSPGSYRCECAAGF 1882
            NA C+N+ GS+RC C  GF
Sbjct: 1553 NARCLNTDGSFRCICRPGF 1571



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 26/85 (30%), Positives = 41/85 (48%), Gaps = 3/85 (3%)

Query: 1242 DIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDEC---ENNPDICDGGQ 1298
            + +EC I++G  + +C      + C C +GY L     +C DI+EC   E    +C   +
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555

Query: 1299 CTNIPGEYRCLCYDGFMASMDMKTC 1323
            C N  G +RC+C  GF  +     C
Sbjct: 1556 CLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 26/84 (30%), Positives = 38/84 (45%), Gaps = 4/84 (4%)

Query: 2653 VDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNEC----SSSKNPCNY 2708
            ++  EC   + C +  C      + C C  G+  D    AC D+NEC    ++S    N 
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 2709 GCSNTEGGYLCGCPPGYYRVGQGH 2732
             C NT+G + C C PG+    Q H
Sbjct: 1555 RCLNTDGSFRCICRPGFAPTHQPH 1578



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 26/77 (33%), Positives = 39/77 (50%), Gaps = 5/77 (6%)

Query: 1449 DVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDEC----SFQNICVFG 1504
            + +EC   ++ C NG+C+ VP  + C C  G+       +C DI+EC    +   +CV  
Sbjct: 1496 EAEECGI-LDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 1505 TCNNLPGMFHCICDDGY 1521
             C N  G F CIC  G+
Sbjct: 1555 RCLNTDGSFRCICRPGF 1571



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 12/89 (13%)

Query: 1848 CEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPN---VC 1903
            C  +D C+NG         C+  P  + C C  G++L     ACVD NEC E      +C
Sbjct: 1500 CGILDGCTNGR--------CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLC 1551

Query: 1904 SHGLCVDLQGSYQCICHNGFKASQDQTMC 1932
             +  C++  GS++CIC  GF  +     C
Sbjct: 1552 VNARCLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 71/269 (26%), Positives = 96/269 (35%), Gaps = 61/269 (22%)

Query: 29   QPQPP--PPKPPRPQPPPQQVRSAT--AGSEGGFLAPEYREEGAAVA-SRVRRRG---QQ 80
            QPQ P  P  P RP PPP   R +T   G  G      Y +  A  A   +  R    Q+
Sbjct: 1109 QPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQE 1168

Query: 81   DVLRGPNVCGSRFHSYCCPGWKT------LPGGNQCIVPI-----------CR----NSC 119
                     GS      CPG +T       P G   + P            C+      C
Sbjct: 1169 CCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVC 1228

Query: 120  GDGFC--SRPN-MCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKG----YIG 172
              G C  + P   C CS+G    T          + C++   CAD+   C+ G     +G
Sbjct: 1229 KSGVCVNTAPGYSCYCSNGYYYHT--------QRLECIDNDECADEEPACEGGRCVNTVG 1280

Query: 173  TY---CGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVN-NQMCQGQ 228
            +Y   C  P+  +G Q   RC+           +      D   G C+ +V  + +C   
Sbjct: 1281 SYHCTCEPPLVLDGSQR--RCV-----------SNESQSLDDNLGVCWQEVGADLVCSHP 1327

Query: 229  LTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257
                  T T CC   G AWG  C +CPAQ
Sbjct: 1328 RLDRQATYTECCCLYGEAWGMDCALCPAQ 1356



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 37/166 (22%), Positives = 67/166 (40%), Gaps = 21/166 (12%)

Query: 90  GSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQC 149
           G R    CC G     G + C +   R    +   +    C     +++ +C  + + +C
Sbjct: 267 GLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSC--EDVDEC 324

Query: 150 SVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCER 209
           +     GG C    C   +G  G  C   VC +G       +  +R +C+      + + 
Sbjct: 325 AT----GGRCQHGECANTRG--GYTC---VCPDGF-----LLDSSRSSCISQHVISEAK- 369

Query: 210 DYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCP 255
               GPCF  + +  C   +   +  +  CC+ +G+AWG  C++CP
Sbjct: 370 ----GPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCP 411



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 3/78 (3%)

Query: 1324 IDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECE--IGAHNCDMH 1381
            ++  EC +    C  G C      F C C  GY +      C D++EC+    A    ++
Sbjct: 1495 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1553

Query: 1382 ASCLNIPGSFKCSCREGW 1399
            A CLN  GSF+C CR G+
Sbjct: 1554 ARCLNTDGSFRCICRPGF 1571



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 28/77 (36%), Positives = 37/77 (48%), Gaps = 5/77 (6%)

Query: 2614 DVDECDGNHRCQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNA----CGSAS 2668
            + +EC     C +G C  +  G+ C C  GY        CVD NEC    A    C +A 
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555

Query: 2669 CYNTLGSYKCACPSGFS 2685
            C NT GS++C C  GF+
Sbjct: 1556 CLNTDGSFRCICRPGFA 1572



 Score = 52.4 bits (124), Expect = 7e-06
 Identities = 33/103 (32%), Positives = 45/103 (43%), Gaps = 5/103 (4%)

Query: 1739 FCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWN-KPCEPCPTPGTADFKTICGNIPGF 1797
            +C+R   G  C + LP   T+ +CC     G AW    C+ C        +    + P  
Sbjct: 251  YCFRELRGGECASPLPGLRTQEVCC--RGAGLAWGVHDCQLCSERLGNSERVSAPDGPCP 308

Query: 1798 T-FDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGF 1839
            T F+   G   D+DEC    G C +G C N  G + C CP GF
Sbjct: 309  TGFERVNGSCEDVDECAT-GGRCQHGECANTRGGYTCVCPDGF 350



 Score = 52.4 bits (124), Expect = 7e-06
 Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 7/88 (7%)

Query: 2570 IDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECD----GNHRCQ 2625
            ++  ECG         G C   P  F+C C  G+ LD T + C D++ECD     +  C 
Sbjct: 1495 LEAEECGILDGC--TNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV 1552

Query: 2626 HG-CQNILGGYRCGCPQGYIQHYQWNQC 2652
            +  C N  G +RC C  G+   +Q + C
Sbjct: 1553 NARCLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 48.9 bits (115), Expect = 7e-05
 Identities = 35/113 (30%), Positives = 43/113 (38%), Gaps = 13/113 (11%)

Query: 2273 GSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPD 2332
            GSY  +    Y   E ++ C  LD C  G          C  +   F C C  G      
Sbjct: 1482 GSYAGSLAEPYEELEAEE-CGILDGCTNG---------RCVRVPEGFTCRCFDGYRLDMT 1531

Query: 2333 GEGCVDENEC---RTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNR 2382
               CVD NEC        +C N RC+N  GS+RC C  GF  +     C   R
Sbjct: 1532 RMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1584



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 4/81 (4%)

Query: 2490 IDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFL--- 2546
            ++ +EC       N  C      + C C  GY L      C D++EC   +         
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 2547 -CVNTLGGFTCKCPPGFTQHH 2566
             C+NT G F C C PGF   H
Sbjct: 1555 RCLNTDGSFRCICRPGFAPTH 1575



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 11/99 (11%)

Query: 2233 GSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMC 2292
            GS+  +  E +E      C  ++ C         RC+     + C C  GY L   +  C
Sbjct: 1482 GSYAGSLAEPYEELEAEECGILDGCTNG------RCVRVPEGFTCRCFDGYRLDMTRMAC 1535

Query: 2293 KDLDECAEGLHDCESR---GMMCKNLIGTFMCICPPGMA 2328
             D++EC E   +  S       C N  G+F CIC PG A
Sbjct: 1536 VDINECDEA--EAASPLCVNARCLNTDGSFRCICRPGFA 1572



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 3/53 (5%)

Query: 1791 CGNIPGFTFDIHTGKAVDIDECKEIPG---ICANGVCINQIGSFRCECPTGFS 1840
            C    G+  D+     VDI+EC E      +C N  C+N  GSFRC C  GF+
Sbjct: 1520 CRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFA 1572



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 16/35 (45%), Positives = 22/35 (62%)

Query: 2446 DGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGY 2480
            D  + DE +    LC N +C+NT GSFRC C+ G+
Sbjct: 1537 DINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1571



 Score = 39.7 bits (91), Expect = 0.044
 Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 3/61 (4%)

Query: 1633 CPGGEGFRPNPITIILEDIDECQELPG---LCQGGNCINTFGSFQCECPQGYYLSEDTRI 1689
            C   +G+R +   +   DI+EC E      LC    C+NT GSF+C C  G+  +     
Sbjct: 1520 CRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHH 1579

Query: 1690 C 1690
            C
Sbjct: 1580 C 1580



 Score = 38.1 bits (87), Expect = 0.13
 Identities = 15/42 (35%), Positives = 22/42 (52%)

Query: 1532 DIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVD 1573
            + +EC     C NG CV  P  + C C   ++L+ T + CVD
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1537



 Score = 35.0 bits (79), Expect = 1.1
 Identities = 13/30 (43%), Positives = 17/30 (56%)

Query: 179 VCENGCQNGGRCIGPNRCACVYGFTGPQCE 208
           +C   C NGG C+ P+RC C   F G  C+
Sbjct: 115 LCPLICHNGGVCVKPDRCLCPPDFAGKFCQ 144


>gi|110347431 latent transforming growth factor beta binding protein 4
            isoform a [Homo sapiens]
          Length = 1624

 Score =  524 bits (1350), Expect = e-148
 Identities = 369/1186 (31%), Positives = 490/1186 (41%), Gaps = 172/1186 (14%)

Query: 706  CYGGIKKGVCVRPFPGAVTKSECCCANPDYGFG-EPCQPCPAK--NSAEFH---GLCSSG 759
            C+  ++ G C  P PG  T+ E CC      +G   CQ C  +  NS       G C +G
Sbjct: 289  CFRELRGGECASPLPGLRTQ-EVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTG 347

Query: 760  VGITVDG--RDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVN 817
                V+G   D++ECA     C +G C N RG Y C C  G+  D+S  +C  I + +++
Sbjct: 348  FE-RVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVIS 403

Query: 818  RLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFN-CE 876
                  G C        C+ P       +   C  + +     C       + G    C 
Sbjct: 404  EA---KGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICP 460

Query: 877  CSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCE 936
              PG   S++     D    T  L  +  R  ++    TL +    + G       E   
Sbjct: 461  AGPGYHYSAS-----DLRYNTRPLGQEPPRVSLS-QPRTLPATSRPSAGFLPTHRLEPRP 514

Query: 937  LDTACPRG-----LARIKGVTCEDVNE-------CEVFPGVCPNGRCVNSKGSFHCECPE 984
                 PR      L  I   T  ++ E       C+  P VC  GRC++    + C C  
Sbjct: 515  EPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDS 574

Query: 985  GLTLDGTGRVCLDIRMEQCYLKWDEDEC-----------IHPVPGKFRMDACCCAVGAAW 1033
            G  L   G  C+D+           DEC               PG FR   C C  G   
Sbjct: 575  GFRLSPQGTRCIDV-----------DECRRVPPPCAPGRCENSPGSFR---CVCGPGFRA 620

Query: 1034 GTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTI 1093
            G    EC                                D++EC   P  C  G+C NT 
Sbjct: 621  GPRAAEC-------------------------------LDVDECHRVPPPCDLGRCENTP 649

Query: 1094 GSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMM 1153
            GSF C C +G+       +C D+DEC  SP LCG G C N PGSF C C  G+       
Sbjct: 650  GSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEE 709

Query: 1154 KNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRN 1213
                D+DEC + P  C  G C NT GSF C CP G         C D++EC+ S   C  
Sbjct: 710  ----DVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTY 765

Query: 1214 GKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYEC-SCSEGY 1272
            G+C N  G++QC C  G+Q       C D+DEC         +C NS GS++C +C  G+
Sbjct: 766  GRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGH 825

Query: 1273 ALMPDGRSCADIDECENNPDICDG-GQCTNIPGEYRCLCYDGFMASMDMK-TCIDVNECD 1330
             L   GR C D+DEC +    C   G CTN  G +RC C  G+ A       C DVNEC 
Sbjct: 826  HLHR-GR-CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC- 882

Query: 1331 LNSNICM-FGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPG 1389
            L  + C   GEC NT GSF C C  GY        C DVDEC     +      C N  G
Sbjct: 883  LEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS--EEDLCQSGICTNTDG 940

Query: 1390 SFKCSCREGWIGNG--IKCIDLDECSNGTHQCSINAQCVNTPGSYRCA--CSEGF-TGDG 1444
            SF+C C  G         C+D+DEC         + +C N+PGSYRC   C  G+  G  
Sbjct: 941  SFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPE 1000

Query: 1445 FTCSDVDECAE-NINLCENGQCLNVPGAYRCE--CEMGFTPASDSRSCQDIDECSFQNIC 1501
             TC DVDEC E    +C   +C N PG+YRC   C+ G+ P      CQD+DEC  ++ C
Sbjct: 1001 GTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFC 1059

Query: 1502 -VFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPIN-CVNGLCVNTPGRYECNCP 1559
                 C NLPG F C+CD GYE  R G +C D++EC      C   LC N  G + C CP
Sbjct: 1060 GAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCP 1119

Query: 1560 --PDFQLNPTGVGCVDNRVGNCYL-----------------------------KFGPRGD 1588
              P+ + +P    CV  R                                   + GP G 
Sbjct: 1120 NSPE-EFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGS 1178

Query: 1589 GSL----------SCNTEIGVGVSRSSCCCSLGKAWGNPC--ETCPPVNSTEYYTLCPGG 1636
            G            +C+  +   V+   CCC++G+ WG+ C  + CP   + EY +LCP G
Sbjct: 1179 GRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHG 1238

Query: 1637 EGF-RPNPITIILEDIDECQELPG-LCQGGNCINTFGSFQCECPQGYYLSEDTRICEDID 1694
             G+  P+    +  D+DECQ     +C+ G C+NT   + C C  GYY       C D D
Sbjct: 1239 RGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDND 1298

Query: 1695 ECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNC-------MDMRKSFCYRSYNG- 1746
            EC      C  G C NT+G+Y C C P  +       C       +D     C++     
Sbjct: 1299 ECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGAD 1358

Query: 1747 TTCEN-ELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC 1791
              C +  L    T   CCC Y  G+AW   C  CP   + DF+ +C
Sbjct: 1359 LVCSHPRLDRQATYTECCCLY--GEAWGMDCALCPAQDSDDFEALC 1402



 Score =  491 bits (1264), Expect = e-138
 Identities = 338/1034 (32%), Positives = 471/1034 (45%), Gaps = 139/1034 (13%)

Query: 1677 CPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMR 1736
            CP G+     +  CED+DEC A  G C  G C NT G YTC+CP  ++  +   +C+   
Sbjct: 344  CPTGFERVNGS--CEDVDEC-ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 400

Query: 1737 -----KSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC 1791
                 K  C+R      C   +  N+TK++CCC+  VGKAW + C+ CP  G+  F+ IC
Sbjct: 401  VISEAKGPCFRVLRDGGCSLPILRNITKQICCCS-RVGKAWGRGCQLCPPFGSEGFREIC 459

Query: 1792 GNIPGFTFDIHTGK-----------AVDIDECKEIPGIC---ANGVCINQIGSFRCECPT 1837
               PG+ +     +            V + + + +P      A  +  +++       P 
Sbjct: 460  PAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPD 519

Query: 1838 GFSYNDLLLVC------EDIDECSNGDNLCQRNAD------CINSPGSYRCECAAGFKLS 1885
                 +L L         +I E      +CQRN        CI+ P  Y C C +GF+LS
Sbjct: 520  PRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLS 579

Query: 1886 PNGA-CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECER--HP 1942
            P G  C+D +EC  +P  C+ G C +  GS++C+C  GF+A      C+DVDEC R   P
Sbjct: 580  PQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPP 639

Query: 1943 CGNGTCKNTVGSYNCLCYPGFELT-HNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLC 2001
            C  G C+NT GS+ C+C  G++   H   C D+DEC+   G +C  G C N  GSF+C+C
Sbjct: 640  CDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPG-LCGRGACKNLPGSFRCVC 698

Query: 2002 NEGYELTPDGKNCI-DTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDIN 2058
              G+     G  C  D +EC   P  C PG C N  GSF C CP G+  +     C D++
Sbjct: 699  PAGFR----GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVD 754

Query: 2059 ECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQ---------SFCFTNFE 2109
            EC   P  C +G C NT G FQC+CP GF  +  G  C D  +           C  +  
Sbjct: 755  ECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPG 814

Query: 2110 NGKC-SVPKAFNTTKAKC-----CCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVP 2163
            + +C + P   +  + +C     C S  P  G    C     + E +F+  C  G+    
Sbjct: 815  SFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCT----NTEGSFRCSCAPGYRAPS 870

Query: 2164 SLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPC 2223
                   DVNECLE      +G+C+NTDGSF C C  GY     G  C+D DECS  + C
Sbjct: 871  GRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLC 930

Query: 2224 GNGTCTNVIGSFECNCNEGFEPGP-MMNCEDINECAQ-NPLLC-AFRCMNTFGSYECT-- 2278
             +G CTN  GSFEC C  G   GP + +C D++EC +  P LC + RC N+ GSY C   
Sbjct: 931  QSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRD 990

Query: 2279 CPIGYALREDQKMCKDLDECAE-GLHDCESRGMMCKNLIGTFMC--ICPPGMARRPDGEG 2335
            C  GY     +  C D+DEC E G   C ++   C+N  G++ C   C PG    P G G
Sbjct: 991  CDPGYH-AGPEGTCDDVDECQEYGPEICGAQ--RCENTPGSYRCTPACDPGYQPTPGG-G 1046

Query: 2336 CVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTIC 2395
            C D +ECR +     +  C N+ GS++C C++G++ +  G  C+D  +     E LQ +C
Sbjct: 1047 CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNE----CETLQGVC 1102

Query: 2396 QMASSSRNLVTKSECCCDG---------GRGWGHQCELCPLPGT---AQYKKICPHGP-- 2441
              A+   N+     C C           GR    +      PG+   A    + P  P  
Sbjct: 1103 G-AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPP 1161

Query: 2442 ------------GYTTDGRDIDEC---KVMPNLCTNGQCINTMGSFRCFCKVGYTTDISG 2486
                        G    GR   EC      P+ C N    N      C C VG   +  G
Sbjct: 1162 PPLPRRPSTPRQGPVGSGR--RECYFDTAAPDACDNILARNVTWQ-ECCCTVG---EGWG 1215

Query: 2487 TSCIDLDECSQSPKPCNYICKNTE-GSYQCSCP--RGYVLQE-DGKTCKDLDECQT-KQH 2541
            + C       Q        C  TE   YQ  CP  RGY+    D    +D+DECQ  +  
Sbjct: 1216 SGC----RIQQ--------CPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQ 1263

Query: 2542 NCQF-LCVNTLGGFTCKCPPGFTQH--HTACIDNNECGSQPSLCGAKGICQNTPGSFSCE 2598
             C+  +CVNT  G++C C  G+  H     CIDN+EC  +   C   G C NT GS+ C 
Sbjct: 1264 VCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEG-GRCVNTVGSYHCT 1322

Query: 2599 CQRGFSLDATGLNC 2612
            C+    LD +   C
Sbjct: 1323 CEPPLVLDGSQRRC 1336



 Score =  472 bits (1214), Expect = e-132
 Identities = 368/1217 (30%), Positives = 501/1217 (41%), Gaps = 201/1217 (16%)

Query: 1436 CSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDEC 1495
            C  G  G  +   D   C+E +    N + ++ P      C  GF   + S  C+D+DEC
Sbjct: 311  CCRG-AGLAWGVHDCQLCSERLG---NSERVSAPDG---PCPTGFERVNGS--CEDVDEC 361

Query: 1496 SFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYE 1555
            +    C  G C N  G + C+C DG+ LD +  +C         I+   G C        
Sbjct: 362  ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCIS----QHVISEAKGPCFRVLRDGG 417

Query: 1556 CNCPPDFQLNPTGVGCVDNRVGNCYLK-------FGPRGDGSLSCNTEIGVGVSRSSCC- 1607
            C+ P     N T   C  +RVG  + +       FG  G   + C    G   S S    
Sbjct: 418  CSLP--ILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREI-CPAGPGYHYSASDLRY 474

Query: 1608 -----------CSLGKAWGNPCETCPPVNSTEYYTLCPGGEGF---RPNPITIILE---- 1649
                        SL +    P  + P       + L P  E     RP P   +      
Sbjct: 475  NTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAW 534

Query: 1650 ---DIDE-------CQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAH 1699
               +I E       CQ  P +C  G CI+    + C C  G+ LS     C D+DEC   
Sbjct: 535  TGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRV 594

Query: 1700 PGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTK 1759
            P  C PG C N+ G++ C+C P +        C+D+ +  C+R                 
Sbjct: 595  PPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDE--CHR---------------VP 637

Query: 1760 RMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGIC 1819
              C    ++G+  N       TPG+  F  +C    G+    H     D+DEC + PG+C
Sbjct: 638  PPC----DLGRCEN-------TPGS--FLCVCP--AGYQAAPHGASCQDVDECTQSPGLC 682

Query: 1820 ANGVCINQIGSFRCECPTGFSYNDLLLVC-EDIDECSNGDNLCQRNADCINSPGSYRCEC 1878
              G C N  GSFRC CP GF  +     C ED+DEC+     C     C N+ GS+ C C
Sbjct: 683  GRGACKNLPGSFRCVCPAGFRGS----ACEEDVDECAQEPPPCGPGR-CDNTAGSFHCAC 737

Query: 1879 AAGFK-LSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDE 1937
             AGF+   P   C D +EC   P  C++G C + +GS+QC+C  GF+ +   + C DVDE
Sbjct: 738  PAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE 797

Query: 1938 CERH-PCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGS 1996
            CE H  C    C N+ GS+ C   P     H   C D+DECSS       +G C N  GS
Sbjct: 798  CENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGS 857

Query: 1997 FKCLCNEGYELTPDGK--NCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYE--VKSE 2052
            F+C C  GY   P G+   C D NEC+        G C N +GSF C C PGY    +  
Sbjct: 858  FRCSCAPGYR-APSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 916

Query: 2053 NCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGK 2112
            +C+D++EC E+ ++C  G CTNT G F+C+CPPG     +   C D  +       E G 
Sbjct: 917  SCLDVDECSEE-DLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDEC-----RERG- 969

Query: 2113 CSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDV 2172
               P    + +    C   PG         C +D        C  G+   P    T +DV
Sbjct: 970  ---PALCGSQR----CENSPGS------YRCVRD--------CDPGYHAGP--EGTCDDV 1006

Query: 2173 NECLE-SPGICSNGQCINTDGSFRC--ECPMGYNLDYTGVRCVDTDECSIGNPCG-NGTC 2228
            +EC E  P IC   +C NT GS+RC   C  GY     G  C D DEC   + CG +  C
Sbjct: 1007 DECQEYGPEICGAQRCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRSFCGAHAVC 1065

Query: 2229 TNVIGSFECNCNEGFEPG-PMMNCEDINECAQNPLLC-AFRCMNTFGSYECTCPIGYALR 2286
             N+ GSF+C C++G+E      +C D+NEC     +C A  C N  GS+ C CP      
Sbjct: 1066 QNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCP------ 1119

Query: 2287 EDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICP-----PGMARRPDGEGCVDENE 2341
                         E       R +  +   GTF    P     P +  RP          
Sbjct: 1120 ----------NSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARP------PPPP 1163

Query: 2342 CRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSS 2401
               +P     G     +GS R EC       ++  +  DN                   +
Sbjct: 1164 LPRRPSTPRQGP----VGSGRREC----YFDTAAPDACDN-----------------ILA 1198

Query: 2402 RNLVTKSECCCDGGRGWGHQCEL--CPLPGTAQYKKICPHGPGYTTDG------RDIDEC 2453
            RN VT  ECCC  G GWG  C +  CP   TA+Y+ +CPHG GY          RD+DEC
Sbjct: 1199 RN-VTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDEC 1257

Query: 2454 KVM-PNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPC-NYICKNTEG 2511
            ++    +C +G C+NT   + C+C  GY        CID DEC+     C    C NT G
Sbjct: 1258 QLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVG 1317

Query: 2512 SYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCP---PGFTQHHTA 2568
            SY C+C    VL    + C   +E Q+   N             C  P      T     
Sbjct: 1318 SYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECC 1376

Query: 2569 CIDNNECGSQPSLCGAK 2585
            C+     G   +LC A+
Sbjct: 1377 CLYGEAWGMDCALCPAQ 1393



 Score =  458 bits (1179), Expect = e-128
 Identities = 293/923 (31%), Positives = 401/923 (43%), Gaps = 156/923 (16%)

Query: 1453 CAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECS-FQNICVFGTCNNLPG 1511
            C  N  +C  G+C++ P  Y C C+ GF  +     C D+DEC      C  G C N PG
Sbjct: 549  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 608

Query: 1512 MFHCICDDGYELDRTGGNCTDIDECAD-PINCVNGLCVNTPGRYECNCPPDFQLNPTGVG 1570
             F C+C  G+        C D+DEC   P  C  G C NTPG + C CP  +Q  P G  
Sbjct: 609  SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGAS 668

Query: 1571 CVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYY 1630
            C D  V  C    G  G G+                           C+  P      + 
Sbjct: 669  CQD--VDECTQSPGLCGRGA---------------------------CKNLPG----SFR 695

Query: 1631 TLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRIC 1690
             +CP G  FR +      ED+DEC + P  C  G C NT GSF C CP G+        C
Sbjct: 696  CVCPAG--FRGSACE---EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPC 750

Query: 1691 EDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCE 1750
            +D+DEC   P  C  G C NT G++ C+CP  +     G  C D+ +           CE
Sbjct: 751  QDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE-----------CE 799

Query: 1751 NELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDID 1810
            N L        C     V    +  C  CP+                   +H G+  D+D
Sbjct: 800  NHLA-------CPGQECVNSPGSFQCRTCPSG----------------HHLHRGRCTDVD 836

Query: 1811 ECKEIPGICA-NGVCINQIGSFRCECPTGF-SYNDLLLVCEDIDECSNGDNLCQRNADCI 1868
            EC      C  +G C N  GSFRC C  G+ + +     C D++EC  GD  C  + +C+
Sbjct: 837  ECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGD-FCFPHGECL 895

Query: 1869 NSPGSYRCECAAGFKLSPNGA-CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQ 1927
            N+ GS+ C CA G++  P GA C+D +EC E  ++C  G+C +  GS++CIC  G +A  
Sbjct: 896  NTDGSFACTCAPGYRPGPRGASCLDVDECSE-EDLCQSGICTNTDGSFECICPPGHRAGP 954

Query: 1928 DQTMCMDVDEC-ERHP--CGNGTCKNTVGSYNCL--CYPGFELTHNNDCLDIDECSSFFG 1982
            D   C+DVDEC ER P  CG+  C+N+ GSY C+  C PG+       C D+DEC  +  
Sbjct: 955  DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGP 1014

Query: 1983 QVCRNGRCFNEIGSFKCL--CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFR 2040
            ++C   RC N  GS++C   C+ GY+ TP G  C D +EC       +   CQNL GSF+
Sbjct: 1015 EICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQ 1073

Query: 2041 CICPPGYEVKSE--NCIDINECDEDPNICLFGSCTNTPGGF----------------QCL 2082
            C+C  GYE   +  +C+D+NEC+    +C    C N  G F                +C+
Sbjct: 1074 CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1133

Query: 2083 CPPGFVLSDNG---------------------RRCFDTRQS--------FCFTNFENGKC 2113
             P     +  G                     RR    RQ           F       C
Sbjct: 1134 PPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDAC 1193

Query: 2114 SVPKAFNTTKAKCCCSKMPGEGWGDPCEL--CPKDDEVAFQDLCPYGHGTVPSLHDT--R 2169
                A N T  +CCC+   GEGWG  C +  CP  +   +Q LCP+G G +    D   R
Sbjct: 1194 DNILARNVTWQECCCTV--GEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLR 1251

Query: 2170 EDVNEC-LESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNP-CGNGT 2227
             DV+EC L    +C +G C+NT   + C C  GY      + C+D DEC+   P C  G 
Sbjct: 1252 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGR 1311

Query: 2228 CTNVIGSFECNCNEGFE-PGPMMNC---------EDINECAQN---PLLCAFRCMNTFGS 2274
            C N +GS+ C C       G    C         +++  C Q     L+C+   ++   +
Sbjct: 1312 CVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQAT 1371

Query: 2275 Y-ECTCPIGYALREDQKMCKDLD 2296
            Y EC C  G A   D  +C   D
Sbjct: 1372 YTECCCLYGEAWGMDCALCPAQD 1394



 Score =  426 bits (1094), Expect = e-118
 Identities = 358/1219 (29%), Positives = 493/1219 (40%), Gaps = 250/1219 (20%)

Query: 214  GPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWG-HPCEMCPAQPQPCRRGFIPNIRTG 272
            G CF ++    C   L G+  T+ +CC   G AWG H C++C  +     R   P     
Sbjct: 287  GYCFRELRGGECASPLPGLR-TQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAP----- 340

Query: 273  ACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG 332
                                       +  CP G ++      CED+DEC+   G C+ G
Sbjct: 341  ---------------------------DGPCPTGFER--VNGSCEDVDECAT-GGRCQHG 370

Query: 333  ECSNTVGSYFCVCPRGYVTSTDGSRCIDQRT-----GMCFSGLVNGRCAQELPGRMTKMQ 387
            EC+NT G Y CVCP G++  +  S CI Q       G CF  L +G C+  +   +TK  
Sbjct: 371  ECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQI 430

Query: 388  CCCEP-GRCWGIGTIPEACPVRGSEEYRRLCMDG--------------LPMGGIPGS--- 429
            CCC   G+ WG G   + CP  GSE +R +C  G               P+G  P     
Sbjct: 431  CCCSRVGKAWGRGC--QLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSL 488

Query: 430  -------AGSRPGGTGGNGFAPSGNGNGYG-------PGGTGFIP-IPGGNGFSPGVGGA 474
                   A SRP      GF P+              PG    +P IP   G  P +  +
Sbjct: 489  SQPRTLPATSRPSA----GFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTG--PEIPES 542

Query: 475  GVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGD-C 533
            G  +G                 +C+ +  +C  GRCI   S Y C C+ G++    G  C
Sbjct: 543  GPSSG-----------------MCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRC 585

Query: 534  IDVDEC--TSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRC 591
            IDVDEC     PC  G C N+PGS+ C C  GF+  P    C+D+DEC +    C  GRC
Sbjct: 586  IDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 645

Query: 592  VNTDGSFQCICNAGFELTTDGKNCVDHDECTTT-NMCLNGMCINEDGSFKCICKPGFVLA 650
             NT GSF C+C AG++    G +C D DECT +  +C  G C N  GSF+C+C  GF   
Sbjct: 646  ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--- 702

Query: 651  PNGRYCT-DVDEC-QTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVD--------- 699
              G  C  DVDEC Q P  C  G C N+ GSF C CP G      G  C D         
Sbjct: 703  -RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPP 761

Query: 700  --THMRSTCYGGIKKGVCVRPFPGAVTKSEC-----------C----CANPDYGFGEPCQ 742
              T+ R     G  + VC   F      SEC           C    C N    F   C+
Sbjct: 762  PCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSF--QCR 819

Query: 743  PCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICA-NGICENLRGSYRCNCNSGYE- 800
             CP+ +     G C+          D++EC+     C  +G C N  GS+RC+C  GY  
Sbjct: 820  TCPSGHHLH-RGRCT----------DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRA 868

Query: 801  PDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINEC-ESN 859
            P      C D++ECL       +G C NT GS++CTC PGY       +C D++EC E +
Sbjct: 869  PSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEED 928

Query: 860  PCVNGACRNNLGSFNCECSPGSKLSSTGLICID----SLKGTCWLNIQDSRCEVNINGAT 915
             C +G C N  GSF C C PG +       C+D      +G      Q  RCE +     
Sbjct: 929  LCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ--RCENSPGSYR 986

Query: 916  LKSECCATLGAAWGSPCE----------------RCE-------LDTACPRGLARIKGVT 952
               +C     A     C+                RCE          AC  G     G  
Sbjct: 987  CVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG 1046

Query: 953  CEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDEC 1012
            C+DV+EC        +  C N  GSF C C +G      GR C+D+         +E E 
Sbjct: 1047 CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDV---------NECET 1097

Query: 1013 IHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPR------GAGF-------A 1059
            +  V G     A C  V  ++   C   P+    E++ +  R       AG        A
Sbjct: 1098 LQGVCGA----ALCENVEGSFLCVCPNSPE----EFDPMTGRCVPPRTSAGTFPGSQPQA 1149

Query: 1060 NRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFAL-----DMEERNCT 1114
                VL  RP    +    + P        +  +GS +  C    A      ++  RN T
Sbjct: 1150 PASPVLPARPPPPPLPRRPSTPR-------QGPVGSGRRECYFDTAAPDACDNILARNVT 1202

Query: 1115 DIDECRISPDLCGSGICVNT-PGSFE------CECFEGY--ESGFMMMKNCMDIDECER- 1164
              + C    +  GSG  +   PG+        C    GY   SG + ++   D+DEC+  
Sbjct: 1203 WQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRR--DVDECQLF 1260

Query: 1165 NPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQ 1224
               +C+ G CVNT   + C C  G+     R +C+D +EC+  +  C  G+CVN +G+Y 
Sbjct: 1261 RDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYH 1320

Query: 1225 CSCNPGYQATPDRQGCTDIDECMIMNG--------GCDTQCT----NSEGSY-ECSCSEG 1271
            C+C P       ++ C   +   + +         G D  C+    + + +Y EC C  G
Sbjct: 1321 CTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYG 1380

Query: 1272 YALMPDGRSC--ADIDECE 1288
             A   D   C   D D+ E
Sbjct: 1381 EAWGMDCALCPAQDSDDFE 1399



 Score =  424 bits (1089), Expect = e-118
 Identities = 299/929 (32%), Positives = 393/929 (42%), Gaps = 135/929 (14%)

Query: 1287 CENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKG 1346
            C+ NP +C  G+C + P  Y C C  GF  S     CIDV+EC      C  G CEN+ G
Sbjct: 549  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 608

Query: 1347 SFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIG--NGI 1404
            SF C C  G+        C DVDEC      CD+   C N PGSF C C  G+    +G 
Sbjct: 609  SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDL-GRCENTPGSFLCVCPAGYQAAPHGA 667

Query: 1405 KCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQ 1464
             C D+DEC+     C   A C N PGS+RC C  GF G      DVDECA+    C  G+
Sbjct: 668  SCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACE-EDVDECAQEPPPCGPGR 725

Query: 1465 CLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNI-CVFGTCNNLPGMFHCICDDGYEL 1523
            C N  G++ C C  GF        CQD+DEC+     C +G C N  G F C+C  G++ 
Sbjct: 726  CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 785

Query: 1524 DRTGGNCTDIDECADPINCVNGLCVNTPGRYECN-CPPDFQLNPTGVGCVDNRVGNCYLK 1582
            +  G  C D+DEC + + C    CVN+PG ++C  CP    L+     C D  V  C   
Sbjct: 786  NTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTD--VDECSSG 841

Query: 1583 FGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPN 1642
              P G      NTE         C C+ G                      P G   RP 
Sbjct: 842  APPCGPHGHCTNTE-----GSFRCSCAPGYR-------------------APSG---RPG 874

Query: 1643 PITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGV 1702
            P      D++EC E       G C+NT GSF C C  GY        C D+DEC +   +
Sbjct: 875  PCA----DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDEC-SEEDL 929

Query: 1703 CGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMC 1762
            C  G C NT G++ CICPP +       +C+D+ +           C    P      +C
Sbjct: 930  CQSGICTNTDGSFECICPPGHRAGPDLASCLDVDE-----------CRERGP-----ALC 973

Query: 1763 CCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEI-PGICAN 1821
                      ++ CE  P      ++ +    PG+      G   D+DEC+E  P IC  
Sbjct: 974  ---------GSQRCENSP----GSYRCVRDCDPGYHAGPE-GTCDDVDECQEYGPEICGA 1019

Query: 1822 GVCINQIGSFRCE--CPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECA 1879
              C N  GS+RC   C  G+        C+D+DEC N  + C  +A C N PGS++C C 
Sbjct: 1020 QRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNR-SFCGAHAVCQNLPGSFQCLCD 1077

Query: 1880 AGFKLSPNGA-CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNG---------------- 1922
             G++ + +G  CVD NEC  +  VC   LC +++GS+ C+C N                 
Sbjct: 1078 QGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRT 1137

Query: 1923 ----FKASQDQTMCMDVDECERHPCGNGTCKNT-----VGSYNCLCYPGFELTHNNDCLD 1973
                F  SQ Q     V      P       +T     VGS    CY  F+    + C +
Sbjct: 1138 SAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECY--FDTAAPDACDN 1195

Query: 1974 I-------DEC----SSFFGQVCRNGRC-FNEIGSFKCLCNEGYE-LTPDGKNCI--DTN 2018
            I        EC       +G  CR  +C   E   ++ LC  G   L P G   +  D +
Sbjct: 1196 ILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVD 1255

Query: 2019 ECVALPGS-CSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPNICLFGSCTNT 2075
            EC       C  G C N    + C C  GY   ++   CID +EC ++   C  G C NT
Sbjct: 1256 ECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNT 1315

Query: 2076 PGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNF-----ENGK---CSVPKA-FNTTKAKC 2126
             G + C C P  VL  + RRC          N      E G    CS P+     T  +C
Sbjct: 1316 VGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTEC 1375

Query: 2127 CCSKMPGEGWGDPCELCPKDDEVAFQDLC 2155
            CC  + GE WG  C LCP  D   F+ LC
Sbjct: 1376 CC--LYGEAWGMDCALCPAQDSDDFEALC 1402



 Score =  418 bits (1075), Expect = e-116
 Identities = 350/1212 (28%), Positives = 480/1212 (39%), Gaps = 267/1212 (22%)

Query: 171  IGTYCGQPVCENG-----CQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMC 225
            I  + G  + E+G     CQ   +  GP RC          C+  +R  P  T+      
Sbjct: 531  IPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRC----- 585

Query: 226  QGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIP 284
               +    C +       GR     CE  P   +  C  GF    R   C DVDEC  +P
Sbjct: 586  ---IDVDECRRVPPPCAPGR-----CENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVP 637

Query: 285  GICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCV 344
              C  G C NT GSF C CPAG++ +     C+D+DEC+  PG+C  G C N  GS+ CV
Sbjct: 638  PPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCV 697

Query: 345  CPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWG-IGTIPE 403
            CP G+     GS C +              CAQE P         C PGRC    G+   
Sbjct: 698  CPAGF----RGSACEED----------VDECAQEPPP--------CGPGRCDNTAGSFHC 735

Query: 404  ACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPG 463
            ACP        R    G P   +   A S P  T G      G+     P          
Sbjct: 736  ACPAG-----FRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCP---------- 780

Query: 464  GNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCE-CN 522
              GF P   G+                  + +D C++H   C    C+ +  S++C  C 
Sbjct: 781  -MGFQPNTAGSEC----------------EDVDECENHL-ACPGQECVNSPGSFQCRTCP 822

Query: 523  MGYKQDANGDCIDVDECTSN--PC-TNGDCVNTPGSYYCKCHAGFQRTPTKQ--ACIDID 577
             G+     G C DVDEC+S   PC  +G C NT GS+ C C  G+ R P+ +   C D++
Sbjct: 823  SGHHLH-RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGY-RAPSGRPGPCADVN 880

Query: 578  ECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDG 637
            EC++      +G C+NTDGSF C C  G+     G +C+D DEC+  ++C +G+C N DG
Sbjct: 881  ECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDG 940

Query: 638  SFKCICKPGFVLAPNGRYCTDVDECQT--PGICMNGHCINSEGSFRC--DCPPGLAVGMD 693
            SF+CIC PG    P+   C DVDEC+   P +C +  C NS GS+RC  DC PG   G +
Sbjct: 941  SFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPE 1000

Query: 694  GRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFH 753
            G  C D                           EC    P+    + C+  P   S    
Sbjct: 1001 G-TCDDV-------------------------DECQEYGPEICGAQRCENTP--GSYRCT 1032

Query: 754  GLCSSGVGITVDG--RDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDI 811
              C  G   T  G  +D++EC       A+ +C+NL GS++C C+ GYE    GR+C+D+
Sbjct: 1033 PACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDV 1092

Query: 812  DECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGAC---RN 868
            +EC   + +C   LC N  GS+ C CP               N  E    + G C   R 
Sbjct: 1093 NECETLQGVCGAALCENVEGSFLCVCP---------------NSPEEFDPMTGRCVPPRT 1137

Query: 869  NLGSF-----NCECSP-----------GSKLSSTGLICIDSLKGTCWLN-IQDSRCEVNI 911
            + G+F         SP             + S+     + S +  C+ +      C+  +
Sbjct: 1138 SAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNIL 1197

Query: 912  NGATLKSECCATLGAAWGSPC--------ERCELDTACPRG---LARIKGVTC-EDVNEC 959
                   ECC T+G  WGS C        E  E  + CP G   LA    ++   DV+EC
Sbjct: 1198 ARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDEC 1257

Query: 960  EVF------PGVCPN-------------------------------------GRCVNSKG 976
            ++F       GVC N                                     GRCVN+ G
Sbjct: 1258 QLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVG 1317

Query: 977  SFHCECPEGLTLDGTGRVC-------LDIRMEQCYLKWDED-ECIHP-VPGKFRMDACCC 1027
            S+HC C   L LDG+ R C       LD  +  C+ +   D  C HP +  +     CCC
Sbjct: 1318 SYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCC 1377

Query: 1028 AVGAAWGTECEECPKPGTKEYETLC----------PRGAGFA-------NRGDVLTGRPF 1070
              G AWG +C  CP   + ++E LC          PR  GF        + G    G P+
Sbjct: 1378 LYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPY 1437

Query: 1071 YKDINECKAFP-------------GMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDID 1117
              ++    A P                 YG  R  +  F+   + G      E       
Sbjct: 1438 GPELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFE---DDGGPYGESEAPAPPGP 1494

Query: 1118 ECR---ISPDLCGSGICVNTP---GSFECECFEGYESGFMMMKNCMDIDECERNPLLCRG 1171
              R    S D   S      P   GS+     E YE   +  + C  +D        C  
Sbjct: 1495 GTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEE--LEAEECGILDG-------CTN 1545

Query: 1172 GTCVNTEGSFQCDCPLGHELSPSREDCVDINEC---SLSDNLCRNGKCVNMIGTYQCSCN 1228
            G CV     F C C  G+ L  +R  CVDINEC     +  LC N +C+N  G+++C C 
Sbjct: 1546 GRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICR 1605

Query: 1229 PGYQATPDRQGC 1240
            PG+  T     C
Sbjct: 1606 PGFAPTHQPHHC 1617



 Score =  392 bits (1007), Expect = e-108
 Identities = 271/841 (32%), Positives = 363/841 (43%), Gaps = 144/841 (17%)

Query: 1983 QVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCI 2042
            QVC  GRC +    + C C+ G+ L+P G  CID +EC  +P  C+PG C+N  GSFRC+
Sbjct: 554  QVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCV 613

Query: 2043 CPPGYEV--KSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR 2100
            C PG+    ++  C+D++EC   P  C  G C NTPG F C+CP G+  + +G  C D  
Sbjct: 614  CGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVD 673

Query: 2101 QSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYG-H 2159
            +                          C++ PG      C+  P     +F+ +CP G  
Sbjct: 674  E--------------------------CTQSPGLCGRGACKNLPG----SFRCVCPAGFR 703

Query: 2160 GTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSI 2219
            G+        EDV+EC + P  C  G+C NT GSF C CP G+     G  C D DEC+ 
Sbjct: 704  GSA-----CEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 758

Query: 2220 GNP-CGNGTCTNVIGSFECNCNEGFEPGPM-MNCEDINECAQNPLLCAFR-CMNTFGSYE 2276
              P C  G C N  GSF+C C  GF+P      CED++EC +N L C  + C+N+ GS++
Sbjct: 759  SPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDEC-ENHLACPGQECVNSPGSFQ 817

Query: 2277 C-TCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEG 2335
            C TCP G+ L   +  C D+DEC+ G   C   G  C N  G+F C C PG  R P G  
Sbjct: 818  CRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGH-CTNTEGSFRCSCAPGY-RAPSGRP 873

Query: 2336 --CVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQT 2393
              C D NEC        +G C+N  GS+ C C  G++    G  CLD  +  C  E L  
Sbjct: 874  GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDE--CSEEDL-- 929

Query: 2394 ICQMASSSRNLVTKSECCCDGGRGWGHQCELC--------------------PLPGTAQY 2433
             CQ    + N     EC C  G   G     C                      PG+ + 
Sbjct: 930  -CQSGICT-NTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRC 987

Query: 2434 KKICPHGPGYTTDGR--DIDECKVM-PNLCTNGQCINTMGSFRCF--CKVGYTTDISGTS 2488
             + C  G     +G   D+DEC+   P +C   +C NT GS+RC   C  GY     G  
Sbjct: 988  VRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-G 1046

Query: 2489 CIDLDEC-SQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNC-QFL 2546
            C D+DEC ++S    + +C+N  GS+QC C +GY    DG+ C D++EC+T Q  C   L
Sbjct: 1047 CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAAL 1106

Query: 2547 CVNTLGGFTCKCPPG---FTQHHTACIDNNEC-----GSQPSLCGAKGICQNTP------ 2592
            C N  G F C CP     F      C+          GSQP    +  +    P      
Sbjct: 1107 CENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPR 1166

Query: 2593 ----------GSFSCECQRGFSLDATGLNCEDVDECDG----NHRCQHGCQNILGGYRCG 2638
                      GS   EC           +    D CD     N   Q  C  +  G+  G
Sbjct: 1167 RPSTPRQGPVGSGRRECY---------FDTAAPDACDNILARNVTWQECCCTVGEGWGSG 1217

Query: 2639 CP-------------------QGYIQ---HYQWNQCVDENECSNPNACGSASCYNTLGSY 2676
            C                    +GY+         + VDE +      C S  C NT   Y
Sbjct: 1218 CRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGY 1277

Query: 2677 KCACPSGFSFDQFSSACHDVNECSSSKNPCNYG-CSNTEGGYLCGC-PPGYYRVGQGHCV 2734
             C C +G+ +      C D +EC+  +  C  G C NT G Y C C PP      Q  CV
Sbjct: 1278 SCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1337

Query: 2735 S 2735
            S
Sbjct: 1338 S 1338



 Score =  377 bits (969), Expect = e-104
 Identities = 281/866 (32%), Positives = 378/866 (43%), Gaps = 143/866 (16%)

Query: 1896 CLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECER--HPCGNGTCKNTVG 1953
            C   P VC  G C+     Y C C +GF+ S   T C+DVDEC R   PC  G C+N+ G
Sbjct: 549  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 608

Query: 1954 SYNCLCYPGFEL-THNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGK 2012
            S+ C+C PGF       +CLD+DEC       C  GRC N  GSF C+C  GY+  P G 
Sbjct: 609  SFRCVCGPGFRAGPRAAECLDVDECHRV-PPPCDLGRCENTPGSFLCVCPAGYQAAPHGA 667

Query: 2013 NCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCI-DINECDEDPNICLFGS 2071
            +C D +EC   PG C  G C+NL GSFRC+CP G+  +   C  D++EC ++P  C  G 
Sbjct: 668  SCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--RGSACEEDVDECAQEPPPCGPGR 725

Query: 2072 CTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKM 2131
            C NT G F C CP GF     G  C D  +                          C++ 
Sbjct: 726  CDNTAGSFHCACPAGFRSRGPGAPCQDVDE--------------------------CARS 759

Query: 2132 PGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTD 2191
            P       CE    + E +FQ +CP G     +  +  EDV+EC E+   C   +C+N+ 
Sbjct: 760  PPPCTYGRCE----NTEGSFQCVCPMGFQPNTAGSEC-EDVDEC-ENHLACPGQECVNSP 813

Query: 2192 GSFRCE-CPMGYNLDYTGVRCVDTDECSIGNP-CG-NGTCTNVIGSFECNCNEGFE---- 2244
            GSF+C  CP G++L + G RC D DECS G P CG +G CTN  GSF C+C  G+     
Sbjct: 814  GSFQCRTCPSGHHL-HRG-RCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSG 871

Query: 2245 -PGPMMNCEDINECAQNPLLCAF-RCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGL 2302
             PGP   C D+NEC +         C+NT GS+ CTC  GY        C D+DEC+E  
Sbjct: 872  RPGP---CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEE- 927

Query: 2303 HDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTK-PGICENGRCVNIIGSY 2361
              C+S   +C N  G+F CICPPG    PD   C+D +ECR + P +C + RC N  GSY
Sbjct: 928  DLCQSG--ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSY 985

Query: 2362 RC--ECNEGFQSSSSGT-----ECLDNRQGLCFAEVLQTI-----CQMASSSRNLVTKSE 2409
            RC  +C+ G+ +   GT     EC +    +C A+  +       C  A       T   
Sbjct: 986  RCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG 1045

Query: 2410 CCCD----GGRGWGHQCELCP-LPGTAQYKKICPHGPGYTTDGR---DIDECKVMPN--- 2458
             C D      R +     +C  LPG+ Q   +C  G     DGR   D++EC+ +     
Sbjct: 1046 GCQDVDECRNRSFCGAHAVCQNLPGSFQC--LCDQGYEGARDGRHCVDVNECETLQGVCG 1103

Query: 2459 --LCTNGQ------CINTMGSF-----RCF---CKVGY---------------------- 2480
              LC N +      C N+   F     RC       G                       
Sbjct: 1104 AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPP 1163

Query: 2481 -----TTDISGTSCIDLDEC---SQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKD 2532
                 +T   G       EC   + +P  C+ I        +C C  G   +  G  C+ 
Sbjct: 1164 LPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVG---EGWGSGCR- 1219

Query: 2533 LDECQ-TKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNT 2591
            + +C  T+    Q LC +  G      P G         D +EC          G+C NT
Sbjct: 1220 IQQCPGTETAEYQSLCPHGRGYLA---PSGDLSLRR---DVDECQLFRDQVCKSGVCVNT 1273

Query: 2592 PGSFSCECQRGFSLDATGLNCEDVDEC-DGNHRCQHG-CQNILGGYRCGCPQGYIQHYQW 2649
               +SC C  G+      L C D DEC D    C+ G C N +G Y C C    +     
Sbjct: 1274 APGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQ 1333

Query: 2650 NQCVDENECSNPNACGSASCYNTLGS 2675
             +CV     S  +  G   C+  +G+
Sbjct: 1334 RRCVSNESQSLDDNLG--VCWQEVGA 1357



 Score =  372 bits (956), Expect = e-102
 Identities = 274/835 (32%), Positives = 375/835 (44%), Gaps = 104/835 (12%)

Query: 1959 CYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTN 2018
            C  GFE   N  C D+DEC++  G  C++G C N  G + C+C +G+ L     +CI  +
Sbjct: 344  CPTGFERV-NGSCEDVDECAT--GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 400

Query: 2019 EC---------VALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICL- 2068
                       V   G CS    +N+     C C    +     C           +C  
Sbjct: 401  VISEAKGPCFRVLRDGGCSLPILRNITKQI-CCCSRVGKAWGRGC----------QLCPP 449

Query: 2069 FGSCTNTPGGFQCLCP--PGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKC 2126
            FGS      GF+ +CP  PG+  S +  R ++TR          G+   P+   +     
Sbjct: 450  FGS-----EGFREICPAGPGYHYSASDLR-YNTRPL--------GQ-EPPRVSLSQPRTL 494

Query: 2127 CCSKMPGEGWGDPCELCPKDD---------EVAFQDLCPYGHGTVPSLHDTREDVNECLE 2177
              +  P  G+     L P+ +         E+    +  +   T P + ++      C  
Sbjct: 495  PATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAW---TGPEIPESGPSSGMCQR 551

Query: 2178 SPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDEC-SIGNPCGNGTCTNVIGSFE 2236
            +P +C  G+CI+    + C C  G+ L   G RC+D DEC  +  PC  G C N  GSF 
Sbjct: 552  NPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFR 611

Query: 2237 CNCNEGFEPGP-MMNCEDINECAQNPLLCAF-RCMNTFGSYECTCPIGYALREDQKMCKD 2294
            C C  GF  GP    C D++EC + P  C   RC NT GS+ C CP GY        C+D
Sbjct: 612  CVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQD 671

Query: 2295 LDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECRTKPGICENGR 2353
            +DEC +    C  RG  CKNL G+F C+CP G      G  C  D +EC  +P  C  GR
Sbjct: 672  VDECTQSPGLC-GRG-ACKNLPGSFRCVCPAGFR----GSACEEDVDECAQEPPPCGPGR 725

Query: 2354 CVNIIGSYRCECNEGFQSSSSGTECLDNRQ----------GLC--FAEVLQTICQMASSS 2401
            C N  GS+ C C  GF+S   G  C D  +          G C       Q +C M    
Sbjct: 726  CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 785

Query: 2402 RNLVTKSECC--CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR--DIDECKV-M 2456
                ++ E    C+       Q E    PG+ Q  + CP G  +   GR  D+DEC    
Sbjct: 786  NTAGSECEDVDECENHLACPGQ-ECVNSPGSFQC-RTCPSG-HHLHRGRCTDVDECSSGA 842

Query: 2457 PNLCTNGQCINTMGSFRCFCKVGYTTDISGT--SCIDLDECSQSPKPCNY-ICKNTEGSY 2513
            P    +G C NT GSFRC C  GY    SG    C D++EC +      +  C NT+GS+
Sbjct: 843  PPCGPHGHCTNTEGSFRCSCAPGYRAP-SGRPGPCADVNECLEGDFCFPHGECLNTDGSF 901

Query: 2514 QCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFT--QHHTACID 2571
             C+C  GY     G +C D+DEC  +      +C NT G F C CPPG        +C+D
Sbjct: 902  ACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLD 961

Query: 2572 NNECGSQ-PSLCGAKGICQNTPGSFSC--ECQRGFSLDATGLNCEDVDECD--GNHRC-Q 2625
             +EC  + P+LCG++  C+N+PGS+ C  +C  G+     G  C+DVDEC   G   C  
Sbjct: 962  VDECRERGPALCGSQR-CENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGA 1019

Query: 2626 HGCQNILGGYRC--GCPQGYIQHYQWNQCVDENECSNPNACGS-ASCYNTLGSYKCACPS 2682
              C+N  G YRC   C  GY Q      C D +EC N + CG+ A C N  GS++C C  
Sbjct: 1020 QRCENTPGSYRCTPACDPGY-QPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQ 1078

Query: 2683 GFSFDQFSSACHDVNECSSSKNPCNYG-CSNTEGGYLCGCP--PGYYRVGQGHCV 2734
            G+   +    C DVNEC + +  C    C N EG +LC CP  P  +    G CV
Sbjct: 1079 GYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1133



 Score =  315 bits (806), Expect = 5e-85
 Identities = 299/1019 (29%), Positives = 385/1019 (37%), Gaps = 251/1019 (24%)

Query: 29   QPQPPPPKPPRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLRGPNV 88
            +P+P P   PRP P           S   +  PE  E G   +S + +R  Q  + GP  
Sbjct: 511  EPRPEPRPDPRPGP------ELPLPSIPAWTGPEIPESGP--SSGMCQRNPQ--VCGPGR 560

Query: 89   CGSRFHSYCC---PGWKTLPGGNQCI-------VP------ICRNS-------CGDGFCS 125
            C SR   Y C    G++  P G +CI       VP       C NS       CG GF +
Sbjct: 561  CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 620

Query: 126  RPNMC-------------TCSSGQISSTCGSKSIQQCSV---RCMNGGTCAD-DHCQCQK 168
             P                 C  G+  +T GS  +  C        +G +C D D C    
Sbjct: 621  GPRAAECLDVDECHRVPPPCDLGRCENTPGS-FLCVCPAGYQAAPHGASCQDVDECTQSP 679

Query: 169  GYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQ 228
            G     CG+  C+N         G  RC C  GF G  CE D     C  +         
Sbjct: 680  G----LCGRGACKN-------LPGSFRCVCPAGFRGSACEED--VDECAQEPP------- 719

Query: 229  LTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQ 288
                 C    C  T G      C  CPA       GF        CQDVDEC   P  C 
Sbjct: 720  ----PCGPGRCDNTAG---SFHC-ACPA-------GFRSRGPGAPCQDVDECARSPPPCT 764

Query: 289  GGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFC-VCPR 347
             G C NT GSF+C CP G + +    +CED+DEC      C   EC N+ GS+ C  CP 
Sbjct: 765  YGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLA-CPGQECVNSPGSFQCRTCPS 823

Query: 348  GYVTSTDGSRCIDQRTGMCFSGL----VNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPE 403
            G+       RC D     C SG      +G C           +C C PG          
Sbjct: 824  GH--HLHRGRCTD--VDECSSGAPPCGPHGHCT----NTEGSFRCSCAPG---------- 865

Query: 404  ACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPG 463
                     YR              +   RPG        P  + N    G   F   P 
Sbjct: 866  ---------YR--------------APSGRPG--------PCADVNECLEGDFCF---PH 891

Query: 464  GNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNM 523
            G   +     A   A G  P   G + L+  +D C    +LC +G C  T  S+ C C  
Sbjct: 892  GECLNTDGSFACTCAPGYRPGPRGASCLD--VDECSEE-DLCQSGICTNTDGSFECICPP 948

Query: 524  GYKQDAN-GDCIDVDECTSNP---CTNGDCVNTPGSYYC--KCHAGFQRTPTKQACIDID 577
            G++   +   C+DVDEC       C +  C N+PGSY C   C  G+   P +  C D+D
Sbjct: 949  GHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGP-EGTCDDVD 1007

Query: 578  ECIQNG-VLCKNGRCVNTDGSFQC--ICNAGFELTTDGKNCVDHDECTTTNMC-LNGMCI 633
            EC + G  +C   RC NT GS++C   C+ G++  T G  C D DEC   + C  + +C 
Sbjct: 1008 ECQEYGPEICGAQRCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRSFCGAHAVCQ 1066

Query: 634  NEDGSFKCICKPGFVLAPNGRYCTDVDECQT-PGICMNGHCINSEGSFRCDCP--PGLAV 690
            N  GSF+C+C  G+  A +GR+C DV+EC+T  G+C    C N EGSF C CP  P    
Sbjct: 1067 NLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFD 1126

Query: 691  GMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGA---------------------------- 722
             M GR CV     +  + G +      P   A                            
Sbjct: 1127 PMTGR-CVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYF 1185

Query: 723  ---------------VTKSECCCANPDYGFGEPC--QPCPAKNSAEFHGLCSSGVGITVD 765
                           VT  ECCC   + G+G  C  Q CP   +AE+  LC  G G    
Sbjct: 1186 DTAAPDACDNILARNVTWQECCCTVGE-GWGSGCRIQQCPGTETAEYQSLCPHGRGYLAP 1244

Query: 766  G------RDINECALDPD-ICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNR 818
                   RD++EC L  D +C +G+C N    Y C C++GY        CID DEC    
Sbjct: 1245 SGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEE 1304

Query: 819  LLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECS 878
              C+ G C NT GSY CTC P  V       C   NE +S                    
Sbjct: 1305 PACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQS-------------------- 1343

Query: 879  PGSKLSSTGLICIDSLKGTCWLNI-QDSRC-EVNINGATLKSECCATLGAAWGSPCERC 935
                        +D   G CW  +  D  C    ++     +ECC   G AWG  C  C
Sbjct: 1344 ------------LDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALC 1390



 Score =  310 bits (795), Expect = 1e-83
 Identities = 184/517 (35%), Positives = 244/517 (47%), Gaps = 59/517 (11%)

Query: 2257 CAQNPLLCA-FRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNL 2315
            C +NP +C   RC++    Y C C  G+ L      C D+DEC      C      C+N 
Sbjct: 549  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPG--RCENS 606

Query: 2316 IGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSG 2375
             G+F C+C PG    P    C+D +EC   P  C+ GRC N  GS+ C C  G+Q++  G
Sbjct: 607  PGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHG 666

Query: 2376 TECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKK 2435
              C D  +                      T+S   C  GRG    C+   LPG+  ++ 
Sbjct: 667  ASCQDVDE---------------------CTQSPGLC--GRG---ACK--NLPGS--FRC 696

Query: 2436 ICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDEC 2495
            +CP G   +    D+DEC   P  C  G+C NT GSF C C  G+ +   G  C D+DEC
Sbjct: 697  VCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDEC 756

Query: 2496 SQSPKPCNY-ICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGF 2554
            ++SP PC Y  C+NTEGS+QC CP G+     G  C+D+DEC+         CVN+ G F
Sbjct: 757  ARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSF 816

Query: 2555 TCK-CPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLN-C 2612
             C+ CP G   H   C D +EC S    CG  G C NT GSF C C  G+   +     C
Sbjct: 817  QCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPC 876

Query: 2613 EDVDEC-DGNHRCQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCY 2670
             DV+EC +G+    HG C N  G + C C  GY    +   C+D +ECS  + C S  C 
Sbjct: 877  ADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICT 936

Query: 2671 NTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYG---CSNTEGGYLC--GCPPGY 2725
            NT GS++C CP G       ++C DV+EC   + P   G   C N+ G Y C   C PGY
Sbjct: 937  NTDGSFECICPPGHRAGPDLASCLDVDEC-RERGPALCGSQRCENSPGSYRCVRDCDPGY 995

Query: 2726 YRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEAC 2762
            +   +G C                +VDE     PE C
Sbjct: 996  HAGPEGTC---------------DDVDECQEYGPEIC 1017



 Score =  235 bits (599), Expect = 5e-61
 Identities = 168/517 (32%), Positives = 229/517 (44%), Gaps = 81/517 (15%)

Query: 2268 CMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI----- 2322
            C       EC  P+   LR  +  C+     A G+HDC+    +C   +G    +     
Sbjct: 289  CFRELRGGECASPLP-GLRTQEVCCRGAG-LAWGVHDCQ----LCSERLGNSERVSAPDG 342

Query: 2323 -CPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDN 2381
             CP G  R      C D +EC T  G C++G C N  G Y C C +GF   SS + C+  
Sbjct: 343  PCPTGFERV--NGSCEDVDECATG-GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQ 399

Query: 2382 R-----QGLCFAEVLQTICQMASSSRNLVTKSECCCDG-GRGWGHQCELCPLPGTAQYKK 2435
                  +G CF  +    C +    RN +TK  CCC   G+ WG  C+LCP  G+  +++
Sbjct: 400  HVISEAKGPCFRVLRDGGCSLPIL-RN-ITKQICCCSRVGKAWGRGCQLCPPFGSEGFRE 457

Query: 2436 ICPHGPGYTTDGRD----------------IDECKVMPNLCTNGQCINTMGSFRCFCKVG 2479
            ICP GPGY     D                + + + +P   T+      + + R   +  
Sbjct: 458  ICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLP--ATSRPSAGFLPTHRLEPRPE 515

Query: 2480 YTTD-----------ISGTSCIDLDECSQSPKPCN---YICKNTEGSYQC-SCPRGYV-- 2522
               D           I   +  ++ E   S   C     +C    G  +C S P GY   
Sbjct: 516  PRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVC----GPGRCISRPSGYTCA 571

Query: 2523 ------LQEDGKTCKDLDECQTKQHNC-QFLCVNTLGGFTCKCPPGFTQHHTA--CIDNN 2573
                  L   G  C D+DEC+     C    C N+ G F C C PGF     A  C+D +
Sbjct: 572  CDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVD 631

Query: 2574 ECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC-DGNHRCQHG-CQNI 2631
            EC   P  C   G C+NTPGSF C C  G+     G +C+DVDEC      C  G C+N+
Sbjct: 632  ECHRVPPPCDL-GRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNL 690

Query: 2632 LGGYRCGCPQGYIQHYQWNQC-VDENECS-NPNACGSASCYNTLGSYKCACPSGFSFDQF 2689
             G +RC CP G    ++ + C  D +EC+  P  CG   C NT GS+ CACP+GF     
Sbjct: 691  PGSFRCVCPAG----FRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGP 746

Query: 2690 SSACHDVNECSSSKNPCNYG-CSNTEGGYLCGCPPGY 2725
             + C DV+EC+ S  PC YG C NTEG + C CP G+
Sbjct: 747  GAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGF 783



 Score =  129 bits (324), Expect = 4e-29
 Identities = 108/389 (27%), Positives = 152/389 (39%), Gaps = 50/389 (12%)

Query: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWG-HQCELCPLPGTAQYKKICPHGPG 2442
            G CF E+    C  AS    L T+  CC   G  WG H C+LC        +   P GP 
Sbjct: 287  GYCFRELRGGEC--ASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPC 344

Query: 2443 YTTDGR------DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECS 2496
             T   R      D+DEC      C +G+C NT G + C C  G+  D S +SCI     S
Sbjct: 345  PTGFERVNGSCEDVDECAT-GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVIS 403

Query: 2497 QSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTC 2556
            ++  PC  + ++      CS P    + +    C  + +   +   CQ        GF  
Sbjct: 404  EAKGPCFRVLRDG----GCSLPILRNITKQICCCSRVGKAWGR--GCQLCPPFGSEGFRE 457

Query: 2557 KCPPGFTQHHTAC---IDNNECGSQP---SLCGAKGI-CQNTPGSFSCECQR-------- 2601
             CP G   H++A     +    G +P   SL   + +   + P +      R        
Sbjct: 458  ICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPR 517

Query: 2602 -----GFSLDATGLNC----EDVDECDGNHRCQHG--------CQNILGGYRCGCPQGYI 2644
                 G  L    +      E  +    +  CQ          C +   GY C C  G+ 
Sbjct: 518  PDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFR 577

Query: 2645 QHYQWNQCVDENECSN-PNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSK 2703
               Q  +C+D +EC   P  C    C N+ GS++C C  GF     ++ C DV+EC    
Sbjct: 578  LSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVP 637

Query: 2704 NPCNYG-CSNTEGGYLCGCPPGYYRVGQG 2731
             PC+ G C NT G +LC CP GY     G
Sbjct: 638  PPCDLGRCENTPGSFLCVCPAGYQAAPHG 666



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 35/99 (35%), Positives = 51/99 (51%), Gaps = 11/99 (11%)

Query: 1262 GSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMK 1321
            GSY  S +E Y  + +   C  +D C N       G+C  +P  + C C+DG+   M   
Sbjct: 1519 GSYAGSLAEPYEEL-EAEECGILDGCTN-------GRCVRVPEGFTCRCFDGYRLDMTRM 1570

Query: 1322 TCIDVNECD---LNSNICMFGECENTKGSFICHCQLGYS 1357
             C+D+NECD     S +C+   C NT GSF C C+ G++
Sbjct: 1571 ACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFA 1609



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 33/77 (42%), Positives = 41/77 (53%), Gaps = 6/77 (7%)

Query: 1491 DIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDEC-----ADPINCVNG 1545
            + +EC   + C  G C  +P  F C C DGY LD T   C DI+EC     A P+ CVN 
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL-CVNA 1591

Query: 1546 LCVNTPGRYECNCPPDF 1562
             C+NT G + C C P F
Sbjct: 1592 RCLNTDGSFRCICRPGF 1608



 Score = 66.2 bits (160), Expect = 4e-10
 Identities = 37/96 (38%), Positives = 45/96 (46%), Gaps = 7/96 (7%)

Query: 2156 PYGHGTVPSLHDTREDVN--ECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVD 2213
            P G     SL +  E++   EC    G C+NG+C+     F C C  GY LD T + CVD
Sbjct: 1516 PEGGSYAGSLAEPYEELEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1574

Query: 2214 TDECSIGNP----CGNGTCTNVIGSFECNCNEGFEP 2245
             +EC         C N  C N  GSF C C  GF P
Sbjct: 1575 INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP 1610



 Score = 65.9 bits (159), Expect = 6e-10
 Identities = 30/93 (32%), Positives = 44/93 (47%), Gaps = 4/93 (4%)

Query: 616  VDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQ----TPGICMNG 671
            ++ +EC   + C NG C+     F C C  G+ L      C D++EC        +C+N 
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 672  HCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRS 704
             C+N++GSFRC C PG A       C     R+
Sbjct: 1592 RCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA 1624



 Score = 65.5 bits (158), Expect = 7e-10
 Identities = 33/91 (36%), Positives = 44/91 (48%), Gaps = 6/91 (6%)

Query: 2015 IDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPN---ICLF 2069
            ++  EC  L G C+ G C  +   F C C  GY +      C+DINECDE      +C+ 
Sbjct: 1532 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1590

Query: 2070 GSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR 2100
              C NT G F+C+C PGF  +     C   R
Sbjct: 1591 ARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1621



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 33/79 (41%), Positives = 39/79 (49%), Gaps = 5/79 (6%)

Query: 1972 LDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNEC---VALPGSCS 2028
            L+ +EC    G  C NGRC      F C C +GY L      C+D NEC    A    C 
Sbjct: 1532 LEAEECGILDG--CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV 1589

Query: 2029 PGTCQNLEGSFRCICPPGY 2047
               C N +GSFRCIC PG+
Sbjct: 1590 NARCLNTDGSFRCICRPGF 1608



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 28/77 (36%), Positives = 45/77 (58%), Gaps = 5/77 (6%)

Query: 2449 DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQ----SPKPCNY 2504
            + +EC ++   CTNG+C+     F C C  GY  D++  +C+D++EC +    SP   N 
Sbjct: 1533 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 2505 ICKNTEGSYQCSCPRGY 2521
             C NT+GS++C C  G+
Sbjct: 1592 RCLNTDGSFRCICRPGF 1608



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 44/142 (30%), Positives = 64/142 (45%), Gaps = 16/142 (11%)

Query: 2103 FCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWG-DPCELCPK----DDEVAFQD-LCP 2156
            +CF     G+C+ P     T+  CC  +  G  WG   C+LC +     + V+  D  CP
Sbjct: 288  YCFRELRGGECASPLPGLRTQEVCC--RGAGLAWGVHDCQLCSERLGNSERVSAPDGPCP 345

Query: 2157 YGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDE 2216
             G   V   + + EDV+EC    G C +G+C NT G + C CP G+ LD +   C+    
Sbjct: 346  TGFERV---NGSCEDVDECATG-GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV 401

Query: 2217 CSIGNPCGNGTCTNVIGSFECN 2238
             S       G C  V+    C+
Sbjct: 402  ISE----AKGPCFRVLRDGGCS 419



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 33/86 (38%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 2212 VDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPG-PMMNCEDINEC----AQNPLLCAF 2266
            ++ +EC I + C NG C  V   F C C +G+      M C DINEC    A +PL    
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 2267 RCMNTFGSYECTCPIGYALREDQKMC 2292
            RC+NT GS+ C C  G+A       C
Sbjct: 1592 RCLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 35/91 (38%), Positives = 47/91 (51%), Gaps = 12/91 (13%)

Query: 1115 DIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPL---LCRG 1171
            + +EC I  D C +G CV  P  F C CF+GY      M  C+DI+EC+       LC  
Sbjct: 1533 EAEECGIL-DGCTNGRCVRVPEGFTCRCFDGYRLDMTRMA-CVDINECDEAEAASPLCVN 1590

Query: 1172 GTCVNTEGSFQCDCPLG-------HELSPSR 1195
              C+NT+GSF+C C  G       H  +P+R
Sbjct: 1591 ARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1621



 Score = 63.2 bits (152), Expect = 4e-09
 Identities = 28/82 (34%), Positives = 45/82 (54%), Gaps = 6/82 (7%)

Query: 1891 VDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHP-----CGN 1945
            ++  EC  I + C++G CV +   + C C +G++    +  C+D++EC+        C N
Sbjct: 1532 LEAEEC-GILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1590

Query: 1946 GTCKNTVGSYNCLCYPGFELTH 1967
              C NT GS+ C+C PGF  TH
Sbjct: 1591 ARCLNTDGSFRCICRPGFAPTH 1612



 Score = 62.4 bits (150), Expect = 6e-09
 Identities = 32/90 (35%), Positives = 43/90 (47%), Gaps = 13/90 (14%)

Query: 1405 KCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGD--GFTCSDVDECAEN---INL 1459
            +C  LD C+NG        +CV  P  + C C +G+  D     C D++EC E      L
Sbjct: 1536 ECGILDGCTNG--------RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL 1587

Query: 1460 CENGQCLNVPGAYRCECEMGFTPASDSRSC 1489
            C N +CLN  G++RC C  GF P      C
Sbjct: 1588 CVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 5/88 (5%)

Query: 1199 VDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGG----CD 1254
            ++  EC + D  C NG+CV +   + C C  GY+    R  C DI+EC           +
Sbjct: 1532 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1590

Query: 1255 TQCTNSEGSYECSCSEGYALMPDGRSCA 1282
             +C N++GS+ C C  G+A       CA
Sbjct: 1591 ARCLNTDGSFRCICRPGFAPTHQPHHCA 1618



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 28/90 (31%), Positives = 40/90 (44%), Gaps = 4/90 (4%)

Query: 276  DVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDEC---SIIPGICETG 332
            + +EC  + G C  G C+     F CRC  G++   T   C DI+EC        +C   
Sbjct: 1533 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 333  ECSNTVGSYFCVCPRGYVTSTDGSRCIDQR 362
             C NT GS+ C+C  G+  +     C   R
Sbjct: 1592 RCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1621



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 31/90 (34%), Positives = 41/90 (45%), Gaps = 4/90 (4%)

Query: 1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDEC---FAHPGVCGPG 1706
            + +EC  L G C  G C+     F C C  GY L      C DI+EC    A   +C   
Sbjct: 1533 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 1707 TCYNTLGNYTCICPPEYMQVNGGHNCMDMR 1736
             C NT G++ CIC P +   +  H+C   R
Sbjct: 1592 RCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1621



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 4/86 (4%)

Query: 1933 MDVDECE-RHPCGNGTCKNTVGSYNCLCYPGFELTHNN-DCLDIDEC--SSFFGQVCRNG 1988
            ++ +EC     C NG C      + C C+ G+ L      C+DI+EC  +     +C N 
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 1989 RCFNEIGSFKCLCNEGYELTPDGKNC 2014
            RC N  GSF+C+C  G+  T    +C
Sbjct: 1592 RCLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 29/79 (36%), Positives = 42/79 (53%), Gaps = 5/79 (6%)

Query: 1807 VDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGD---NLCQR 1863
            ++ +EC  + G C NG C+     F C C  G+  +   + C DI+EC   +    LC  
Sbjct: 1532 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV- 1589

Query: 1864 NADCINSPGSYRCECAAGF 1882
            NA C+N+ GS+RC C  GF
Sbjct: 1590 NARCLNTDGSFRCICRPGF 1608



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 26/85 (30%), Positives = 41/85 (48%), Gaps = 3/85 (3%)

Query: 1242 DIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDEC---ENNPDICDGGQ 1298
            + +EC I++G  + +C      + C C +GY L     +C DI+EC   E    +C   +
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592

Query: 1299 CTNIPGEYRCLCYDGFMASMDMKTC 1323
            C N  G +RC+C  GF  +     C
Sbjct: 1593 CLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 26/84 (30%), Positives = 38/84 (45%), Gaps = 4/84 (4%)

Query: 2653 VDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNEC----SSSKNPCNY 2708
            ++  EC   + C +  C      + C C  G+  D    AC D+NEC    ++S    N 
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 2709 GCSNTEGGYLCGCPPGYYRVGQGH 2732
             C NT+G + C C PG+    Q H
Sbjct: 1592 RCLNTDGSFRCICRPGFAPTHQPH 1615



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 26/77 (33%), Positives = 39/77 (50%), Gaps = 5/77 (6%)

Query: 1449 DVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDEC----SFQNICVFG 1504
            + +EC   ++ C NG+C+ VP  + C C  G+       +C DI+EC    +   +CV  
Sbjct: 1533 EAEECGI-LDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 1505 TCNNLPGMFHCICDDGY 1521
             C N  G F CIC  G+
Sbjct: 1592 RCLNTDGSFRCICRPGF 1608



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 12/89 (13%)

Query: 1848 CEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPN---VC 1903
            C  +D C+NG         C+  P  + C C  G++L     ACVD NEC E      +C
Sbjct: 1537 CGILDGCTNGR--------CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLC 1588

Query: 1904 SHGLCVDLQGSYQCICHNGFKASQDQTMC 1932
             +  C++  GS++CIC  GF  +     C
Sbjct: 1589 VNARCLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 71/269 (26%), Positives = 96/269 (35%), Gaps = 61/269 (22%)

Query: 29   QPQPP--PPKPPRPQPPPQQVRSAT--AGSEGGFLAPEYREEGAAVA-SRVRRRG---QQ 80
            QPQ P  P  P RP PPP   R +T   G  G      Y +  A  A   +  R    Q+
Sbjct: 1146 QPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQE 1205

Query: 81   DVLRGPNVCGSRFHSYCCPGWKT------LPGGNQCIVPI-----------CR----NSC 119
                     GS      CPG +T       P G   + P            C+      C
Sbjct: 1206 CCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVC 1265

Query: 120  GDGFC--SRPN-MCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKG----YIG 172
              G C  + P   C CS+G    T          + C++   CAD+   C+ G     +G
Sbjct: 1266 KSGVCVNTAPGYSCYCSNGYYYHT--------QRLECIDNDECADEEPACEGGRCVNTVG 1317

Query: 173  TY---CGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVN-NQMCQGQ 228
            +Y   C  P+  +G Q   RC+           +      D   G C+ +V  + +C   
Sbjct: 1318 SYHCTCEPPLVLDGSQR--RCV-----------SNESQSLDDNLGVCWQEVGADLVCSHP 1364

Query: 229  LTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257
                  T T CC   G AWG  C +CPAQ
Sbjct: 1365 RLDRQATYTECCCLYGEAWGMDCALCPAQ 1393



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 37/166 (22%), Positives = 67/166 (40%), Gaps = 21/166 (12%)

Query: 90  GSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQC 149
           G R    CC G     G + C +   R    +   +    C     +++ +C  + + +C
Sbjct: 304 GLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSC--EDVDEC 361

Query: 150 SVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCER 209
           +     GG C    C   +G  G  C   VC +G       +  +R +C+      + + 
Sbjct: 362 AT----GGRCQHGECANTRG--GYTC---VCPDGF-----LLDSSRSSCISQHVISEAK- 406

Query: 210 DYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCP 255
               GPCF  + +  C   +   +  +  CC+ +G+AWG  C++CP
Sbjct: 407 ----GPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCP 448



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 3/78 (3%)

Query: 1324 IDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECE--IGAHNCDMH 1381
            ++  EC +    C  G C      F C C  GY +      C D++EC+    A    ++
Sbjct: 1532 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1590

Query: 1382 ASCLNIPGSFKCSCREGW 1399
            A CLN  GSF+C CR G+
Sbjct: 1591 ARCLNTDGSFRCICRPGF 1608



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 28/77 (36%), Positives = 37/77 (48%), Gaps = 5/77 (6%)

Query: 2614 DVDECDGNHRCQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNA----CGSAS 2668
            + +EC     C +G C  +  G+ C C  GY        CVD NEC    A    C +A 
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592

Query: 2669 CYNTLGSYKCACPSGFS 2685
            C NT GS++C C  GF+
Sbjct: 1593 CLNTDGSFRCICRPGFA 1609



 Score = 52.4 bits (124), Expect = 7e-06
 Identities = 33/103 (32%), Positives = 45/103 (43%), Gaps = 5/103 (4%)

Query: 1739 FCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWN-KPCEPCPTPGTADFKTICGNIPGF 1797
            +C+R   G  C + LP   T+ +CC     G AW    C+ C        +    + P  
Sbjct: 288  YCFRELRGGECASPLPGLRTQEVCC--RGAGLAWGVHDCQLCSERLGNSERVSAPDGPCP 345

Query: 1798 T-FDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGF 1839
            T F+   G   D+DEC    G C +G C N  G + C CP GF
Sbjct: 346  TGFERVNGSCEDVDECAT-GGRCQHGECANTRGGYTCVCPDGF 387



 Score = 52.4 bits (124), Expect = 7e-06
 Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 7/88 (7%)

Query: 2570 IDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECD----GNHRCQ 2625
            ++  ECG         G C   P  F+C C  G+ LD T + C D++ECD     +  C 
Sbjct: 1532 LEAEECGILDGC--TNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV 1589

Query: 2626 HG-CQNILGGYRCGCPQGYIQHYQWNQC 2652
            +  C N  G +RC C  G+   +Q + C
Sbjct: 1590 NARCLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 48.9 bits (115), Expect = 7e-05
 Identities = 35/113 (30%), Positives = 43/113 (38%), Gaps = 13/113 (11%)

Query: 2273 GSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPD 2332
            GSY  +    Y   E ++ C  LD C  G          C  +   F C C  G      
Sbjct: 1519 GSYAGSLAEPYEELEAEE-CGILDGCTNG---------RCVRVPEGFTCRCFDGYRLDMT 1568

Query: 2333 GEGCVDENEC---RTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNR 2382
               CVD NEC        +C N RC+N  GS+RC C  GF  +     C   R
Sbjct: 1569 RMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1621



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 4/81 (4%)

Query: 2490 IDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFL--- 2546
            ++ +EC       N  C      + C C  GY L      C D++EC   +         
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 2547 -CVNTLGGFTCKCPPGFTQHH 2566
             C+NT G F C C PGF   H
Sbjct: 1592 RCLNTDGSFRCICRPGFAPTH 1612



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 11/99 (11%)

Query: 2233 GSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMC 2292
            GS+  +  E +E      C  ++ C         RC+     + C C  GY L   +  C
Sbjct: 1519 GSYAGSLAEPYEELEAEECGILDGCTNG------RCVRVPEGFTCRCFDGYRLDMTRMAC 1572

Query: 2293 KDLDECAEGLHDCESR---GMMCKNLIGTFMCICPPGMA 2328
             D++EC E   +  S       C N  G+F CIC PG A
Sbjct: 1573 VDINECDEA--EAASPLCVNARCLNTDGSFRCICRPGFA 1609



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 3/53 (5%)

Query: 1791 CGNIPGFTFDIHTGKAVDIDECKEIPG---ICANGVCINQIGSFRCECPTGFS 1840
            C    G+  D+     VDI+EC E      +C N  C+N  GSFRC C  GF+
Sbjct: 1557 CRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFA 1609



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 16/35 (45%), Positives = 22/35 (62%)

Query: 2446 DGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGY 2480
            D  + DE +    LC N +C+NT GSFRC C+ G+
Sbjct: 1574 DINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1608



 Score = 39.7 bits (91), Expect = 0.044
 Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 3/61 (4%)

Query: 1633 CPGGEGFRPNPITIILEDIDECQELPG---LCQGGNCINTFGSFQCECPQGYYLSEDTRI 1689
            C   +G+R +   +   DI+EC E      LC    C+NT GSF+C C  G+  +     
Sbjct: 1557 CRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHH 1616

Query: 1690 C 1690
            C
Sbjct: 1617 C 1617



 Score = 38.1 bits (87), Expect = 0.13
 Identities = 15/42 (35%), Positives = 22/42 (52%)

Query: 1532 DIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVD 1573
            + +EC     C NG CV  P  + C C   ++L+ T + CVD
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1574



 Score = 37.4 bits (85), Expect = 0.22
 Identities = 34/131 (25%), Positives = 46/131 (35%), Gaps = 23/131 (17%)

Query: 97  CCPGWKTLPGGNQCIVPICR-NSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMN 155
           CCPG  +    ++CI   CR  SC    C+ P  C      + S   S   +Q S+    
Sbjct: 55  CCPGQTSRR--SRCIRAFCRVRSCQPKKCAGPQRCLNPVPAVPSPSPSVRKRQVSLNWQP 112

Query: 156 ------------------GGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCA 197
                             GG         Q+   G      +C   C NGG C+ P+RC 
Sbjct: 113 LTLQEARALLKRRRPRGPGGRGLLRRRPPQRAPAGK--APVLCPLICHNGGVCVKPDRCL 170

Query: 198 CVYGFTGPQCE 208
           C   F G  C+
Sbjct: 171 CPPDFAGKFCQ 181


>gi|4557733 latent transforming growth factor beta binding protein 2
            [Homo sapiens]
          Length = 1821

 Score =  494 bits (1271), Expect = e-139
 Identities = 280/771 (36%), Positives = 389/771 (50%), Gaps = 73/771 (9%)

Query: 1073 DINECKAFPGMCT-YGKCRNTIGSFKCRCNSGFALDME--ERNCTDIDECRISPDLCGSG 1129
            D NEC   P  C   G+C N +GS+ C C  G+ L      + C DI+EC   P +C  G
Sbjct: 887  DDNECLRDP--CKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECE-QPGVCSGG 943

Query: 1130 ICVNTPGSFECECFEGYESGFMMMK-NCMDIDECERNPLLCRGGTCVNTEGSFQC-DCPL 1187
             C NT GS+ CEC +GY    M+ K +C DI+EC R+P  C  G CVN+ GS+ C  C  
Sbjct: 944  QCTNTEGSYHCECDQGY---IMVRKGHCQDINEC-RHPGTCPDGRCVNSPGSYTCLACEE 999

Query: 1188 GHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECM 1247
            G+        CVD+NEC L+  +C +GKC N+ G+++CSC  GY+ T D +GC D+DEC 
Sbjct: 1000 GYRGQSG--SCVDVNEC-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECA 1056

Query: 1248 IMNGGCDTQ-CTNSEGSYECS-CSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGE 1305
                 C T  C N+EGS+ CS C  GY +  DG +C D+DEC   P +C  G CTN  G 
Sbjct: 1057 -SRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAF-PGVCPSGVCTNTAGS 1114

Query: 1306 YRCL-CYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTG 1364
            + C  C  G+  S    +C DV+EC+   + C+ GEC+NT GS+ C C  G+ +  GT  
Sbjct: 1115 FSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTV- 1173

Query: 1365 CTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIG--NGIKCIDLDECSNGTHQCSIN 1422
            C DV+EC +G  +C  H  CLN  GSF C C  G++    G  C D+DEC+  T  C + 
Sbjct: 1174 CEDVNEC-MGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECAT-TDPC-VG 1230

Query: 1423 AQCVNTPGSYRCACSEGF--TGDGFTCSDVDECAENIN-LCENGQCLNVPGAYRCE--CE 1477
              CVNT GS+ C C  GF  + +   C D+DEC +  + +C   +C N PG+YRC   C+
Sbjct: 1231 GHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQ 1290

Query: 1478 MGFTPASDSRSCQDIDECSFQNIC-VFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDEC 1536
             GF  A +   C DIDEC+   +C   G C+N  G F C+CD G+E+  +G +C D++EC
Sbjct: 1291 PGFHMAPNG-DCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNEC 1349

Query: 1537 ADPIN-CVNGLCVNTPGRYECNCPPDFQLNPTGVG-CVDNRVGNCYLKFGPRGD------ 1588
               +  C   LC N  G + C C  D +      G C     G   +   P GD      
Sbjct: 1350 ELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPT 1409

Query: 1589 ---------GSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGF 1639
                     G   C++ +G   +++ CCC+ G +WG+ C+ CP  +S E+  +CP G+G+
Sbjct: 1410 RMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGY 1469

Query: 1640 RPNPIT-----IILEDIDECQEL-PGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDI 1693
             P          +  D DEC    PGLC  G C+NT   + C C  G++     + CED 
Sbjct: 1470 IPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDH 1529

Query: 1694 DECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCM------------DMRKSFCY 1741
            DEC      C  G C NT G++ C C P          CM            D+    C+
Sbjct: 1530 DEC--QDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICW 1587

Query: 1742 RSYNGTTCENEL-PFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC 1791
            +      C   L     T   CCC    G+AW++ C  CP   +  +  +C
Sbjct: 1588 KKVTNDVCSEPLRGHRTTYTECCC--QDGEAWSQQCALCPPRSSEVYAQLC 1636



 Score =  464 bits (1193), Expect = e-130
 Identities = 379/1340 (28%), Positives = 536/1340 (40%), Gaps = 260/1340 (19%)

Query: 214  GPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHP-CEMCPAQPQPCRRGFIPNIRTG 272
            G C+    N  C   L  +  T+  CC ++G  WG   C  CP +P        P I  G
Sbjct: 552  GRCYLNTVNGQCANPLLELT-TQEDCCGSVGAFWGVTLCAPCPPRPAS------PVIENG 604

Query: 273  ACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG 332
                                       +  CP G+K+   T  C+DI+EC  + G+C+  
Sbjct: 605  ---------------------------QLECPQGYKRLNLTH-CQDINECLTL-GLCKDA 635

Query: 333  ECSNTVGSYFCVCPRGYVTSTDGSRCIDQRT-----GMCFSGLVNGRCAQELPGRMTKMQ 387
            EC NT GSY C C  G +     SRC+  +      G+C+  L  G C   L  R+TK  
Sbjct: 636  ECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQI 695

Query: 388  CCCEP-GRCWGIGTIPEACPVRGSEEYRRLCMDG-----------LPM------------ 423
            CCC   G+ WG     E CP+ G+E +R +C  G           L M            
Sbjct: 696  CCCSRVGKAWGSEC--EKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPP 753

Query: 424  --------GGIPGSAGSRPGGTGGN-----GFAPSGNGNGYGPGGTGFIPIPG---GNGF 467
                    G +PG A  +P     +     G  P    +  G   T     P    GN  
Sbjct: 754  REQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNAT 813

Query: 468  SPGVGGAGVGAGGQGPIITG----LTILNQTIDICKHHA-NLCLNGRCIPTVSSYRCECN 522
            +P +   G+    +  +       +T+    ID C   A N+C  G C+     YRC C+
Sbjct: 814  TPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCS 873

Query: 523  MGYK-QDANGDCIDVDECTSNPCTN-GDCVNTPGSYYCKCHAGFQRTPT--KQACIDIDE 578
             GY+   +   C D +EC  +PC   G C+N  GSY C C+ G+    +   Q C DI+E
Sbjct: 874  PGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINE 933

Query: 579  CIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGS 638
            C Q GV C  G+C NT+GS+ C C+ G+ +   G +C D +EC     C +G C+N  GS
Sbjct: 934  CEQPGV-CSGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINECRHPGTCPDGRCVNSPGS 991

Query: 639  FKCI-CKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVC 697
            + C+ C+ G+        C DV+EC TPG+C +G C N EGSFRC C  G  V  D + C
Sbjct: 992  YTCLACEEGY--RGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGC 1049

Query: 698  VDTH---MRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHG 754
             D      R++C      G+C+    G+   S C      Y   E    C   +   F G
Sbjct: 1050 QDVDECASRASC----PTGLCLNT-EGSFACSAC---ENGYWVNEDGTACEDLDECAFPG 1101

Query: 755  LCSSGVGITVDG--------------------RDINECALDPDICANGICENLRGSYRCN 794
            +C SGV     G                     D++EC      C  G C+N  GSY+C 
Sbjct: 1102 VCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCL 1161

Query: 795  CNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDIN 854
            C  G++  A+G  C D++EC+       +G C N+ GS+ C C PG+V      +C+D++
Sbjct: 1162 CPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVD 1220

Query: 855  ECES-NPCVNGACRNNLGSFNCECSPGSKLSSTGLICID---------SLKGT--CWLNI 902
            EC + +PCV G C N  GSFNC C  G + S     C+D          + GT  C  + 
Sbjct: 1221 ECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSP 1280

Query: 903  QDSRCEVNI--------NGATLKSECCA--TLGAAWGSPCERCE--LDTACPRGLA-RIK 949
               RC +          NG  +  + CA  T+  + G  C+  +      C +G      
Sbjct: 1281 GSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGF-CDNTDGSFRCLCDQGFEISPS 1339

Query: 950  GVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTL----------DGTGRVCLD-- 997
            G  C DVNECE+   VC    C N +GSF C C   L             G G   +   
Sbjct: 1340 GWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEA 1399

Query: 998  ---------IRMEQCYLKWDEDECIHPVPGKFRMDA-CCCAVGAAWGTECEECPKPGTKE 1047
                      RM+ CY           V G+    A CCC  GA+WG  C+ CP   + E
Sbjct: 1400 PTGDHAPAPTRMD-CYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAE 1458

Query: 1048 YETLCPRGAGFAN-RGDVLTGRPFYKDINECKAF-PGMCTYGKCRNTI------------ 1093
            +  +CP G G+    G    G+  Y D +EC  F PG+C  G+C NT+            
Sbjct: 1459 FSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFH 1518

Query: 1094 ----------------------------GSFKCRCNSGFALDMEERNCTD---------- 1115
                                        GSF C C+    LD+ ++ C +          
Sbjct: 1519 YDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPD 1578

Query: 1116 ----IDEC--RISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLC 1169
                +D C  +++ D+C   +  +     EC C +G E+       C      E    LC
Sbjct: 1579 HDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDG-EAWSQQCALCPPRSS-EVYAQLC 1636

Query: 1170 RGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNP 1229
                 +  E         G+E  P  +D         S          N +G       P
Sbjct: 1637 NVAR-IEAEREAGVHFRPGYEYGPGPDDL------HYSIYGPDGAPFYNYLGPEDTVPEP 1689

Query: 1230 GYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECEN 1289
             +  T         D   I+      Q +  +  Y  S  E     P G      +EC  
Sbjct: 1690 AFPNTAGHSA----DRTPILES--PLQPSELQPHYVASHPEP----PAGFEGLQAEEC-G 1738

Query: 1290 NPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNEC-DLN--SNICMFGECENTKG 1346
              + C+ G+C  +   Y C C++GF        C+DVNEC DLN  + +C+ G CENT+G
Sbjct: 1739 ILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEG 1798

Query: 1347 SFICHCQLGYSVKKGTTGCT 1366
            S+ CHC  GY  + G   CT
Sbjct: 1799 SYRCHCSPGYVAEAGPPHCT 1818



 Score =  440 bits (1131), Expect = e-122
 Identities = 318/1027 (30%), Positives = 442/1027 (43%), Gaps = 135/1027 (13%)

Query: 1116 IDECRI-SPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRG-GT 1173
            ID C   + ++CG G CVN P  + C C  GY+        C D +EC R+P  C+G G 
Sbjct: 845  IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQL-HPSQAYCTDDNECLRDP--CKGKGR 901

Query: 1174 CVNTEGSFQCDCPLGHELSPS--REDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGY 1231
            C+N  GS+ C C  G+ L+ S   ++C DINEC     +C  G+C N  G+Y C C+ GY
Sbjct: 902  CINRVGSYSCFCYPGYTLATSGATQECQDINECE-QPGVCSGGQCTNTEGSYHCECDQGY 960

Query: 1232 QATPDRQG-CTDIDECMIMNGGCDTQCTNSEGSYEC-SCSEGYALMPDGRSCADIDECEN 1289
                 R+G C DI+EC       D +C NS GSY C +C EGY       SC D++EC  
Sbjct: 961  IMV--RKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVNECLT 1016

Query: 1290 NPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFI 1349
             P +C  G+CTN+ G +RC C  G+  + D K C DV+EC   ++ C  G C NT+GSF 
Sbjct: 1017 -PGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRAS-CPTGLCLNTEGSFA 1074

Query: 1350 CH-CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCS-CREGWIGN--GIK 1405
            C  C+ GY V +  T C D+DEC      C     C N  GSF C  C  G+  +  G  
Sbjct: 1075 CSACENGYWVNEDGTACEDLDECAFPGV-CPSGV-CTNTAGSFSCKDCDGGYRPSPLGDS 1132

Query: 1406 CIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT-GDGFTCSDVDECAENINLCENGQ 1464
            C D+DEC +    C +  +C NT GSY+C C +GF   +G  C DV+EC    +   +G+
Sbjct: 1133 CEDVDECEDPQSSC-LGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGE 1191

Query: 1465 CLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELD 1524
            CLN  G++ C C  GF  A    SCQD+DEC+  + CV G C N  G F+C+C+ G++  
Sbjct: 1192 CLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPS 1251

Query: 1525 RTGGNCTDIDEC---ADPINCVNGLCVNTPGRYEC--NCPPDFQLNPTGVGCVDNRVGNC 1579
               G C DIDEC    DP+ C    C N+PG Y C   C P F + P G  C+D  +  C
Sbjct: 1252 PESGECVDIDECEDYGDPV-CGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCID--IDEC 1307

Query: 1580 YLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGF 1639
                                  +  + C S G             ++T+    C   +GF
Sbjct: 1308 ----------------------ANDTMCGSHGFC-----------DNTDGSFRCLCDQGF 1334

Query: 1640 RPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAH 1699
              +P      D++EC+ +  +C    C N  GSF C C              D++E  A 
Sbjct: 1335 EISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLC------------ASDLEEYDAQ 1382

Query: 1700 PGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNG-TTCENELPFNVT 1758
             G C P       G  +    P      G H     R   CY    G   C + L  N T
Sbjct: 1383 EGHCRP----RGAGGQSMSEAP-----TGDHAPAPTRMD-CYSGQKGHAPCSSVLGRNTT 1432

Query: 1759 KRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGF-----TFDIHTGKAVDIDECK 1813
            +  CCCT   G +W   C+ CP+  +A+F  IC +  G+      +        D DEC 
Sbjct: 1433 QAECCCTQ--GASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECV 1490

Query: 1814 EI-PGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPG 1872
               PG+C NG C+N +  + C C  GF Y+     CED DEC    +L   N +C+N+ G
Sbjct: 1491 IFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDEC---QDLACENGECVNTEG 1547

Query: 1873 SYRCECAAGFKLS-PNGACVDRNECLE-IP---------------NVCSHGLCVDLQGSY 1915
            S+ C C+    L      C++     E +P               +VCS  L        
Sbjct: 1548 SFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYT 1607

Query: 1916 QCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDID 1975
            +C C +G   SQ   +C            N               PG+E     D L   
Sbjct: 1608 ECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHY- 1666

Query: 1976 ECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNL 2035
               S +G        +N +G    +    +  T         +    L     P   Q  
Sbjct: 1667 ---SIYGP--DGAPFYNYLGPEDTVPEPAFPNTAGH----SADRTPILESPLQPSELQPH 1717

Query: 2036 EGSFRCICPPGYE-VKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGR 2094
              +     P G+E +++E C  +N C+        G C     G+ C C  GF L     
Sbjct: 1718 YVASHPEPPAGFEGLQAEECGILNGCEN-------GRCVRVREGYTCDCFEGFQLDAAHM 1770

Query: 2095 RCFDTRQ 2101
             C D  +
Sbjct: 1771 ACVDVNE 1777



 Score =  439 bits (1128), Expect = e-122
 Identities = 287/815 (35%), Positives = 377/815 (46%), Gaps = 109/815 (13%)

Query: 1771 AW---NKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKE-IPGICANGVCIN 1826
            AW   N    P P  G A+ +     +   T  + T     ID C      +C  G C+N
Sbjct: 806  AWVTGNATTPPMPEQGIAEIQE--EQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVN 863

Query: 1827 QIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSP 1886
                +RC C  G+  +     C D +EC      C+    CIN  GSY C C  G+ L+ 
Sbjct: 864  LPDGYRCVCSPGYQLHPSQAYCTDDNECLRDP--CKGKGRCINRVGSYSCFCYPGYTLAT 921

Query: 1887 NGA---CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHP- 1942
            +GA   C D NEC E P VCS G C + +GSY C C  G+   + +  C D++EC RHP 
Sbjct: 922  SGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCECDQGYIMVR-KGHCQDINEC-RHPG 978

Query: 1943 -CGNGTCKNTVGSYNCL-CYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCL 2000
             C +G C N+ GSY CL C  G+    +  C+D++EC +    VC +G+C N  GSF+C 
Sbjct: 979  TCPDGRCVNSPGSYTCLACEEGYR-GQSGSCVDVNECLT--PGVCAHGKCTNLEGSFRCS 1035

Query: 2001 CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRC-ICPPGYEVKSEN--CIDI 2057
            C +GYE+T D K C D +EC A   SC  G C N EGSF C  C  GY V  +   C D+
Sbjct: 1036 CEQGYEVTSDEKGCQDVDEC-ASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDL 1094

Query: 2058 NECDEDPNICLFGSCTNTPGGFQCL-CPPGFVLSDNGRRCFDTR-----QSFCFTNFENG 2111
            +EC   P +C  G CTNT G F C  C  G+  S  G  C D       QS C      G
Sbjct: 1095 DEC-AFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCL----GG 1149

Query: 2112 KCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTRED 2171
            +C      NT  +  C              LCP+  ++A   +C              ED
Sbjct: 1150 ECK-----NTVGSYQC--------------LCPQGFQLANGTVC--------------ED 1176

Query: 2172 VNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNV 2231
            VNEC+       +G+C+N+ GSF C C  G+     G  C D DEC+  +PC  G C N 
Sbjct: 1177 VNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNT 1236

Query: 2232 IGSFECNCNEGFEPGPMM-NCEDINECAQ--NPLLCAFRCMNTFGSYECT--CPIGYALR 2286
             GSF C C  GF+P P    C DI+EC    +P+   ++C N+ GSY C   C  G+ + 
Sbjct: 1237 EGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMA 1296

Query: 2287 EDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKP 2346
             +   C D+DECA     C S G  C N  G+F C+C  G    P G  CVD NEC    
Sbjct: 1297 PNGD-CIDIDECANDTM-CGSHG-FCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELML 1353

Query: 2347 GICENGRCVNIIGSYRCEC-----------------NEGFQSSS---SGTECLDNRQGLC 2386
             +C    C N+ GS+ C C                   G QS S   +G       +  C
Sbjct: 1354 AVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDC 1413

Query: 2387 FAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGY--- 2443
            ++         +   RN  T++ECCC  G  WG  C+LCP   +A++ +ICP G GY   
Sbjct: 1414 YSGQKGHAPCSSVLGRN-TTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPV 1472

Query: 2444 -------TTDGRDIDECKVM-PNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDEC 2495
                    T   D DEC +  P LC NG+C+NT+  + C C  G+  D S   C D DEC
Sbjct: 1473 EGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDEC 1532

Query: 2496 SQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTC 2530
             Q     N  C NTEGS+ C C     L    + C
Sbjct: 1533 -QDLACENGECVNTEGSFHCFCSPPLTLDLSQQRC 1566



 Score =  408 bits (1048), Expect = e-113
 Identities = 372/1375 (27%), Positives = 522/1375 (37%), Gaps = 331/1375 (24%)

Query: 24   QGTAGQPQPPPPK-PPRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDV 82
            +GT  + QPP P+ PP PQ PP       AG+  G       ++   ++  VR       
Sbjct: 254  EGTLARAQPPAPQSPPAPQSPP-------AGTLSGLSQTHPSQQHVGLSRTVR------- 299

Query: 83   LRGPNVCGSRFHSYCCPGWKTLP--GGNQCIVP--------------------------I 114
            L       S+  S   P    L    G Q  VP                          I
Sbjct: 300  LHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPTI 359

Query: 115  CRNSCGDGFCSRPNMCTCSSGQISSTCGSKS----------IQQCSVRCMNGGTC-ADDH 163
            C+ +C  G C+     +C  G  ++                I  C + C+NGG C   D 
Sbjct: 360  CKQTCARGHCAN----SCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCLNGGRCIGRDE 415

Query: 164  CQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACV----YGFTGPQCERDYRTGPCFTQ 219
            C C     G +C  P+ +   +  GR   P            FT P   +     P   +
Sbjct: 416  CWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTFTLPLSNQLASVNPSLVK 475

Query: 220  VN-----------NQMCQ---GQLTGIV--CTKTLCCATIGRAWGH-------------- 249
            V+           +Q+ Q   G    +V    +T     +  + GH              
Sbjct: 476  VHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWDSNNIPARSGE 535

Query: 250  -PCEMCPAQPQPCRRGFIP----NIRTGACQDVDECQAIPGICQGGNCINTVGSFE---- 300
             P  + PA P+P  RG +     N   G C        +  +    +C  +VG+F     
Sbjct: 536  PPRPLPPAAPRP--RGLLGRCYLNTVNGQC-----ANPLLELTTQEDCCGSVGAFWGVTL 588

Query: 301  -CRCPA---------GHKQSETTQKCEDIDECSIIPGICETGECS-----NTVGSYFCVC 345
               CP          G  +     K  ++  C  I      G C      NT GSY C C
Sbjct: 589  CAPCPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTC 648

Query: 346  PRGYVTSTDGSRCIDQRT-----GMCFSGLVNGRCAQELPGRMTKMQCCC-EPGRCWGIG 399
              G +     SRC+  +      G+C+  L  G C   L  R+TK  CCC   G+ W  G
Sbjct: 649  RPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAW--G 706

Query: 400  TIPEACPVRGSEEYRRLCMDG-----------LPM--------------------GGIPG 428
            +  E CP+ G+E +R +C  G           L M                    G +PG
Sbjct: 707  SECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPG 766

Query: 429  SAGSRPGGTGGN-----GFAPSGNGNGYGPGGTGFIPIPG---GNGFSPGVGGAGVGAGG 480
             A  +P     +     G  P    +  G   T     P    GN  +P +   G+    
Sbjct: 767  PAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQ 826

Query: 481  QGPIITG----LTILNQTIDICKHHA-NLCLNGRCIPTVSSYRCECNMGYK-QDANGDCI 534
            +  +       +T+    ID C   A N+C  G C+     YRC C+ GY+   +   C 
Sbjct: 827  EEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCT 886

Query: 535  DVDECTSNPCT-NGDCVNTPGSYYCKCHAGF--QRTPTKQACIDIDECIQNGVLCKNGRC 591
            D +EC  +PC   G C+N  GSY C C+ G+    +   Q C DI+EC Q GV C  G+C
Sbjct: 887  DDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGV-CSGGQC 945

Query: 592  VNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCI-CKPGFVLA 650
             NT+GS+ C C+ G+ +   G +C D +EC     C +G C+N  GS+ C+ C+ G+   
Sbjct: 946  TNTEGSYHCECDQGYIMVRKG-HCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGY--R 1002

Query: 651  PNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTH---MRSTCY 707
                 C DV+EC TPG+C +G C N EGSFRC C  G  V  D + C D      R++C 
Sbjct: 1003 GQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCP 1062

Query: 708  GGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDG- 766
             G+                   C N +  F      C A         C +G  +  DG 
Sbjct: 1063 TGL-------------------CLNTEGSFA-----CSA---------CENGYWVNEDGT 1089

Query: 767  --RDINECALDPDICANGICENLRGSYRC-NCNSGYEPDASGRNCIDIDECLVNRLLCDN 823
               D++ECA  P +C +G+C N  GS+ C +C+ GY P   G +C D+DEC   +  C  
Sbjct: 1090 ACEDLDECAF-PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLG 1148

Query: 824  GLCRNTPGSYSCTCPPGYVFRTETETCEDINEC--ESNPCVNGACRNNLGSFNCECSPGS 881
            G C+NT GSY C CP G+     T  CED+NEC  E +   +G C N+ GSF C C+PG 
Sbjct: 1149 GECKNTVGSYQCLCPQGFQLANGT-VCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGF 1207

Query: 882  KLSSTGLICID---------SLKGTCWLNIQDS---RCEVNINGATLKSEC--------- 920
              +  G  C D          + G C +N + S    CE     +    EC         
Sbjct: 1208 VSAEGGTSCQDVDECATTDPCVGGHC-VNTEGSFNCLCETGFQPSPESGECVDIDECEDY 1266

Query: 921  ----CATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKG 976
                C T          RC L   C  G        C D++EC        +G C N+ G
Sbjct: 1267 GDPVCGTWKCENSPGSYRCVL--GCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDG 1324

Query: 977  SFHCECPEGLTLDGTGRVCLDI----------------RMEQCYL--------KWDEDE- 1011
            SF C C +G  +  +G  C+D+                 +E  +L        ++D  E 
Sbjct: 1325 SFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEG 1384

Query: 1012 ----------------CIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRG 1055
                                 P   RMD   C  G      C       T + E  C +G
Sbjct: 1385 HCRPRGAGGQSMSEAPTGDHAPAPTRMD---CYSGQKGHAPCSSVLGRNTTQAECCCTQG 1441

Query: 1056 AGFANRGDVLT--------------------------GRPFYKDINECKAF-PGMCTYGK 1088
            A + +  D+                            G+  Y D +EC  F PG+C  G+
Sbjct: 1442 ASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGR 1501

Query: 1089 CRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDL-CGSGICVNTPGSFECEC 1142
            C NT+  + C CN GF  D   + C D DEC+   DL C +G CVNT GSF C C
Sbjct: 1502 CLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ---DLACENGECVNTEGSFHCFC 1553



 Score =  402 bits (1033), Expect = e-111
 Identities = 325/1091 (29%), Positives = 458/1091 (41%), Gaps = 207/1091 (18%)

Query: 1608 CSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQG-GNC 1666
            C+ G    N C     VN  + Y  C    G++ +P      D +EC   P  C+G G C
Sbjct: 848  CAAGAT--NVCGPGTCVNLPDGYR-CVCSPGYQLHPSQAYCTDDNECLRDP--CKGKGRC 902

Query: 1667 INTFGSFQCECPQGYYLSED--TRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYM 1724
            IN  GS+ C C  GY L+    T+ C+DI+EC   PGVC  G C NT G+Y C C   Y+
Sbjct: 903  INRVGSYSCFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCECDQGYI 961

Query: 1725 QVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGT 1784
             V  GH C D+ +      + GT  +             C  + G      CE       
Sbjct: 962  MVRKGH-CQDINEC----RHPGTCPDGR-----------CVNSPGSYTCLACEE------ 999

Query: 1785 ADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDL 1844
                          +   +G  VD++EC   PG+CA+G C N  GSFRC C  G+     
Sbjct: 1000 -------------GYRGQSGSCVDVNECLT-PGVCAHGKCTNLEGSFRCSCEQGYEVTSD 1045

Query: 1845 LLVCEDIDECSNGDNLCQRNADCINSPGSYRCE-CAAGFKLSPNG-ACVDRNECLEIPNV 1902
               C+D+DEC++  + C     C+N+ GS+ C  C  G+ ++ +G AC D +EC   P V
Sbjct: 1046 EKGCQDVDECASRAS-CPTGL-CLNTEGSFACSACENGYWVNEDGTACEDLDEC-AFPGV 1102

Query: 1903 CSHGLCVDLQGSYQC-ICHNGFKASQDQTMCMDVDECE--RHPCGNGTCKNTVGSYNCLC 1959
            C  G+C +  GS+ C  C  G++ S     C DVDECE  +  C  G CKNTVGSY CLC
Sbjct: 1103 CPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLC 1162

Query: 1960 YPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNE 2019
              GF+L +   C D++EC         +G C N  GSF CLC  G+     G +C D +E
Sbjct: 1163 PQGFQLANGTVCEDVNECMG-EEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDE 1221

Query: 2020 CVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDE--DPNICLFGSCTNT 2075
            C A    C  G C N EGSF C+C  G++   E+  C+DI+EC++  DP +C    C N+
Sbjct: 1222 C-ATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDP-VCGTWKCENS 1279

Query: 2076 PGGFQCL--CPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPG 2133
            PG ++C+  C PGF ++ NG  C D  +                        C    M G
Sbjct: 1280 PGSYRCVLGCQPGFHMAPNG-DCIDIDE------------------------CANDTMCG 1314

Query: 2134 -EGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDG 2192
              G+ D       + + +F+ LC  G    PS  D   DVNEC     +C    C N +G
Sbjct: 1315 SHGFCD-------NTDGSFRCLCDQGFEISPSGWDC-VDVNECELMLAVCGAALCENVEG 1366

Query: 2193 SFRCECPMGYNLDY---------TGVRCVDTDECSIGNPC-------------GNGTCTN 2230
            SF C C      +Y          G       E   G+               G+  C++
Sbjct: 1367 SFLCLCASDLE-EYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSS 1425

Query: 2231 VIG----SFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALR 2286
            V+G      EC C +G   G   +     + A+   +C         S +   P+  A  
Sbjct: 1426 VLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICP--------SGKGYIPVEGAWT 1477

Query: 2287 EDQKMCKDLDECA-EGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTK 2345
              Q M  D DEC   G   C +    C N +  ++C+C PG       + C D +EC+  
Sbjct: 1478 FGQTMYTDADECVIFGPGLCPNG--RCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDL 1535

Query: 2346 PGICENGRCVNIIGSYRCECN---------EGFQSSSSGTECL---DNRQGLCFAEVLQT 2393
               CENG CVN  GS+ C C+         +   +S+S TE L   D    +C+ +V   
Sbjct: 1536 --ACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTND 1593

Query: 2394 ICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKIC---------------- 2437
            +C          T +ECCC  G  W  QC LCP   +  Y ++C                
Sbjct: 1594 VCSEPLRGHR-TTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFR 1652

Query: 2438 ---PHGPG--------YTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISG 2486
                +GPG        Y  DG          +        NT          G++ D + 
Sbjct: 1653 PGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNT---------AGHSADRTP 1703

Query: 2487 TSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYV-LQEDGKTCKDLDECQTKQHNCQF 2545
                 L      P   +Y+  + E       P G+  LQ   + C  L+ C+  +     
Sbjct: 1704 ILESPLQPSELQP---HYVASHPEP------PAGFEGLQ--AEECGILNGCENGR----- 1747

Query: 2546 LCVNTLGGFTCKCPPGF--TQHHTACIDNNECG--SQPSLCGAKGICQNTPGSFSCECQR 2601
             CV    G+TC C  GF     H AC+D NEC   + P++    G C+NT GS+ C C  
Sbjct: 1748 -CVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSP 1806

Query: 2602 GFSLDATGLNC 2612
            G+  +A   +C
Sbjct: 1807 GYVAEAGPPHC 1817



 Score =  392 bits (1007), Expect = e-108
 Identities = 256/745 (34%), Positives = 342/745 (45%), Gaps = 125/745 (16%)

Query: 1851 IDECSNG-DNLCQRNADCINSPGSYRCECAAGFKLSPNGA-CVDRNECLEIPNVCS-HGL 1907
            ID C+ G  N+C     C+N P  YRC C+ G++L P+ A C D NECL  P  C   G 
Sbjct: 845  IDRCAAGATNVCGPGT-CVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDP--CKGKGR 901

Query: 1908 CVDLQGSYQCICHNGFK-ASQDQTM-CMDVDECERHP-CGNGTCKNTVGSYNCLCYPGFE 1964
            C++  GSY C C+ G+  A+   T  C D++ECE+   C  G C NT GSY+C C  G+ 
Sbjct: 902  CINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYI 961

Query: 1965 LTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCL-CNEGYELTPDGKNCIDTNECVAL 2023
            +     C DI+EC       C +GRC N  GS+ CL C EGY       +C+D NEC+  
Sbjct: 962  MVRKGHCQDINECRH--PGTCPDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVNECLT- 1016

Query: 2024 PGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPNICLFGSCTNTPGGFQC 2081
            PG C+ G C NLEGSFRC C  GYEV S+   C D++EC    + C  G C NT G F C
Sbjct: 1017 PGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRAS-CPTGLCLNTEGSFAC 1075

Query: 2082 -LCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPC 2140
              C  G+ ++++G  C D  +        +G C+      +   K C         GD C
Sbjct: 1076 SACENGYWVNEDGTACEDLDECAFPGVCPSGVCT--NTAGSFSCKDCDGGYRPSPLGDSC 1133

Query: 2141 ELCPKDDEV--------------AFQDLCPYG----HGTVPSLHDTREDVNECLESPGIC 2182
            E   + ++               ++Q LCP G    +GTV       EDVNEC+      
Sbjct: 1134 EDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVC------EDVNECMGEEHCA 1187

Query: 2183 SNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEG 2242
             +G+C+N+ GSF C C  G+     G  C D DEC+  +PC  G C N  GSF C C  G
Sbjct: 1188 PHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETG 1247

Query: 2243 FEPGPMMN-CEDINECAQ--NPLLCAFRCMNTFGSYECT--CPIGYALREDQKMCKDLDE 2297
            F+P P    C DI+EC    +P+   ++C N+ GSY C   C  G+ +  +   C D+DE
Sbjct: 1248 FQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGD-CIDIDE 1306

Query: 2298 CAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNI 2357
            CA     C S G  C N  G+F C+C  G    P G  CVD NEC     +C    C N+
Sbjct: 1307 CANDTM-CGSHGF-CDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENV 1364

Query: 2358 IGSYRCEC-----------------NEGFQSSS---SGTECLDNRQGLCFAEVLQTICQM 2397
             GS+ C C                   G QS S   +G       +  C++         
Sbjct: 1365 EGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCS 1424

Query: 2398 ASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYT----------TDG 2447
            +   RN  T++ECCC  G  WG  C+LCP   +A++ +ICP G GY           T  
Sbjct: 1425 SVLGRN-TTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMY 1483

Query: 2448 RDIDECKVM-----PN------------------------------------LCTNGQCI 2466
             D DEC +      PN                                     C NG+C+
Sbjct: 1484 TDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECV 1543

Query: 2467 NTMGSFRCFCKVGYTTDISGTSCID 2491
            NT GSF CFC    T D+S   C++
Sbjct: 1544 NTEGSFHCFCSPPLTLDLSQQRCMN 1568



 Score =  391 bits (1005), Expect = e-108
 Identities = 262/880 (29%), Positives = 371/880 (42%), Gaps = 168/880 (19%)

Query: 1362 TTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW--IGNGIKCIDLDECSNGTHQC 1419
            T     +D C  GA N     +C+N+P  ++C C  G+    +   C D +EC      C
Sbjct: 839  TLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLR--DPC 896

Query: 1420 SINAQCVNTPGSYRCACSEGFT----GDGFTCSDVDECAENINLCENGQCLNVPGAYRCE 1475
                +C+N  GSY C C  G+T    G    C D++EC E   +C  GQC N  G+Y CE
Sbjct: 897  KGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCE 955

Query: 1476 CEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCI-CDDGYELDRTGGNCTDID 1534
            C+ G+        CQDI+EC     C  G C N PG + C+ C++GY      G+C D++
Sbjct: 956  CDQGYIMVRKGH-CQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVN 1012

Query: 1535 ECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFG-PRG-----D 1588
            EC  P  C +G C N  G + C+C   +++     GC D  V  C  +   P G     +
Sbjct: 1013 ECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQD--VDECASRASCPTGLCLNTE 1070

Query: 1589 GSLSCNT-EIGVGVSRSSCCC-SLGK-AWGNPCETCPPVNSTEYYTLCPGGEGFRPNPIT 1645
            GS +C+  E G  V+     C  L + A+   C +    N+   ++      G+RP+P+ 
Sbjct: 1071 GSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLG 1130

Query: 1646 IILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGP 1705
               ED+DEC++    C GG C NT GS+QC CPQG+ L+  T +CED++EC         
Sbjct: 1131 DSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGT-VCEDVNECMGEEHCAPH 1189

Query: 1706 GTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCEN-ELPFNVTKRMCCC 1764
            G C N+ G++ C+C P ++   GG +C D+ +        G  C N E  FN     C C
Sbjct: 1190 GECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFN-----CLC 1244

Query: 1765 TYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEI-PGICANGV 1823
                                           GF     +G+ VDIDEC++    +C    
Sbjct: 1245 E-----------------------------TGFQPSPESGECVDIDECEDYGDPVCGTWK 1275

Query: 1824 CINQIGSFRC--ECPTGFSY---NDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCEC 1878
            C N  GS+RC   C  GF      D    C DIDEC+N D +C  +  C N+ GS+RC C
Sbjct: 1276 CENSPGSYRCVLGCQPGFHMAPNGD----CIDIDECAN-DTMCGSHGFCDNTDGSFRCLC 1330

Query: 1879 AAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFK------------- 1924
              GF++SP+G  CVD NEC  +  VC   LC +++GS+ C+C +  +             
Sbjct: 1331 DQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRG 1390

Query: 1925 ---------ASQDQTMCMDVDECERHPCGNGTCKNTVG----SYNCLCYPG------FEL 1965
                      + D        +C     G+  C + +G       C C  G       +L
Sbjct: 1391 AGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL 1450

Query: 1966 THNNDC---------------------------LDIDECSSFFGQVCRNGRCFNEIGSFK 1998
              + D                             D DEC  F   +C NGRC N +  + 
Sbjct: 1451 CPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYV 1510

Query: 1999 CLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPP--GYEVKSENCID 2056
            CLCN G+      K C D +EC  L  +C  G C N EGSF C C P    ++  + C++
Sbjct: 1511 CLCNPGFHYDASHKKCEDHDECQDL--ACENGECVNTEGSFHCFCSPPLTLDLSQQRCMN 1568

Query: 2057 INECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVP 2116
                 ED                         L D+     D     C+    N  CS P
Sbjct: 1569 STSSTED-------------------------LPDH-----DIHMDICWKKVTNDVCSEP 1598

Query: 2117 -KAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLC 2155
             +   TT  +CCC    GE W   C LCP      +  LC
Sbjct: 1599 LRGHRTTYTECCC--QDGEAWSQQCALCPPRSSEVYAQLC 1636



 Score =  389 bits (999), Expect = e-107
 Identities = 306/1066 (28%), Positives = 426/1066 (39%), Gaps = 202/1066 (18%)

Query: 576  IDECIQNGV-LCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCIN 634
            ID C      +C  G CVN    ++C+C+ G++L      C D +EC        G CIN
Sbjct: 845  IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904

Query: 635  EDGSFKCICKPGFVLAPNG--RYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGM 692
              GS+ C C PG+ LA +G  + C D++EC+ PG+C  G C N+EGS+ C+C  G  +  
Sbjct: 905  RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR 964

Query: 693  DGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEF 752
             G  C D +      G    G CV   PG+ T                C  C       +
Sbjct: 965  KGH-CQDIN-ECRHPGTCPDGRCVNS-PGSYT----------------CLAC----EEGY 1001

Query: 753  HGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDID 812
             G   S V       D+NEC L P +CA+G C NL GS+RC+C  GYE  +  + C D+D
Sbjct: 1002 RGQSGSCV-------DVNEC-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVD 1053

Query: 813  ECLVNRLLCDNGLCRNTPGSYSCT-CPPGYVFRTETETCEDINECE-SNPCVNGACRNNL 870
            EC  +R  C  GLC NT GS++C+ C  GY    +   CED++EC     C +G C N  
Sbjct: 1054 EC-ASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTA 1112

Query: 871  GSFNC-ECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWG 929
            GSF+C +C  G + S  G  C D              CE +   + L  EC  T+G+   
Sbjct: 1113 GSFSCKDCDGGYRPSPLGDSCEDV-----------DECE-DPQSSCLGGECKNTVGS--- 1157

Query: 930  SPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLD 989
                       CP+G     G  CEDVNEC       P+G C+NS GSF C C  G    
Sbjct: 1158 -------YQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSA 1210

Query: 990  GTGRVCLDIRMEQCYLKWDEDECI--HPV--PGKFRMDACCCAVGAAWGTECEECP---- 1041
              G  C D+  ++C      D C+  H V   G F    C C  G     E  EC     
Sbjct: 1211 EGGTSCQDV--DECATT---DPCVGGHCVNTEGSFN---CLCETGFQPSPESGECVDIDE 1262

Query: 1042 ----------------KPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMC- 1084
                             PG+      C  G   A  GD +       DI+EC A   MC 
Sbjct: 1263 CEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCI-------DIDEC-ANDTMCG 1314

Query: 1085 TYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFE 1144
            ++G C NT GSF+C C+ GF +     +C D++EC +   +CG+ +C N  GSF C C  
Sbjct: 1315 SHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCAS 1374

Query: 1145 GYESGFMMMKNC------------------------MDIDECERNPLLCRG--------G 1172
              E       +C                        MD    ++    C           
Sbjct: 1375 DLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQA 1434

Query: 1173 TCVNTEGSF---QCD-------------CPLGHELSP-------SREDCVDINECSL-SD 1208
             C  T+G+     CD             CP G    P        +    D +EC +   
Sbjct: 1435 ECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGP 1494

Query: 1209 NLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDT-QCTNSEGSYECS 1267
             LC NG+C+N +  Y C CNPG+      + C D DEC  +   C+  +C N+EGS+ C 
Sbjct: 1495 GLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDL--ACENGECVNTEGSFHCF 1552

Query: 1268 CSEGYAL-------MPDGRSCADIDECENNPDICDGGQCTNIPGE---------YRCLCY 1311
            CS    L       M    S  D+ + + + DIC      ++  E           C C 
Sbjct: 1553 CSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQ 1612

Query: 1312 DGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDEC 1371
            DG   S     C      ++ + +C     E  + + + H + GY               
Sbjct: 1613 DGEAWSQQCALC-PPRSSEVYAQLCNVARIEAEREAGV-HFRPGY--------------- 1655

Query: 1372 EIGAHNCDMHASCLNIPGS--FKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTP 1429
            E G    D+H S     G+  +     E  +            ++ T       Q     
Sbjct: 1656 EYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQ 1715

Query: 1430 GSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSC 1489
              Y  +  E     GF     +EC   +N CENG+C+ V   Y C+C  GF   +   +C
Sbjct: 1716 PHYVASHPE--PPAGFEGLQAEECGI-LNGCENGRCVRVREGYTCDCFEGFQLDAAHMAC 1772

Query: 1490 QDIDECSFQN----ICVFGTCNNLPGMFHCICDDGYELDRTGGNCT 1531
             D++EC   N    +CV G C N  G + C C  GY  +    +CT
Sbjct: 1773 VDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCT 1818



 Score =  365 bits (937), Expect = e-100
 Identities = 277/898 (30%), Positives = 375/898 (41%), Gaps = 150/898 (16%)

Query: 1942 PCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLC 2001
            PC        + +    C  G++  +   C DI+EC +    +C++  C N  GS+ C C
Sbjct: 591  PCPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTL--GLCKDAECVNTRGSYLCTC 648

Query: 2002 NEGYELTPDGKNCIDTNECVALPGSC----SPGTC-----QNLEGSFRCICPPGYEVKSE 2052
              G  L P    C+       L G C     PGTC     Q +     C    G    S 
Sbjct: 649  RPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGS- 707

Query: 2053 NCIDINECDEDPNICLFGSCTNTPG--GFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFEN 2110
                  EC++ P           PG   F+ +CP G     +G     +         E 
Sbjct: 708  ------ECEKCP----------LPGTEAFREICPAG-----HGYTYASSDIRLSMRKAEE 746

Query: 2111 GKCSVPKAFNTTKAKCCCSKMPG-----------EGWGDPCELCPKDDEVAFQDLCPY-- 2157
             + + P      ++      +PG           + W +   +  K D  A Q       
Sbjct: 747  EELARPPREQGQRSS---GALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTH 803

Query: 2158 ------GHGTVPSLHD------------TREDVNECLESPGI----------CSNGQCIN 2189
                  G+ T P + +               DV   L +PGI          C  G C+N
Sbjct: 804  APAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVN 863

Query: 2190 TDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPC-GNGTCTNVIGSFECNCNEGF---EP 2245
                +RC C  GY L  +   C D +EC + +PC G G C N +GS+ C C  G+     
Sbjct: 864  LPDGYRCVCSPGYQLHPSQAYCTDDNEC-LRDPCKGKGRCINRVGSYSCFCYPGYTLATS 922

Query: 2246 GPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDC 2305
            G    C+DINEC Q  +    +C NT GSY C C  GY +   +  C+D++EC    H  
Sbjct: 923  GATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR-KGHCQDINECR---HPG 978

Query: 2306 ESRGMMCKNLIGTFMCI-CPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCE 2364
                  C N  G++ C+ C  G   R     CVD NEC T PG+C +G+C N+ GS+RC 
Sbjct: 979  TCPDGRCVNSPGSYTCLACEEGY--RGQSGSCVDVNECLT-PGVCAHGKCTNLEGSFRCS 1035

Query: 2365 CNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCEL 2424
            C +G++ +S    C D  +    A     +C        L T+    C            
Sbjct: 1036 CEQGYEVTSDEKGCQDVDECASRASCPTGLC--------LNTEGSFACSA---------- 1077

Query: 2425 CPLPGTAQYKKICPHGPGYTTDG---RDIDECKVMPNLCTNGQCINTMGSFRC-FCKVGY 2480
                        C +G     DG    D+DEC   P +C +G C NT GSF C  C  GY
Sbjct: 1078 ------------CENGYWVNEDGTACEDLDEC-AFPGVCPSGVCTNTAGSFSCKDCDGGY 1124

Query: 2481 TTDISGTSCIDLDECSQSPKPC-NYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTK 2539
                 G SC D+DEC      C    CKNT GSYQC CP+G+ L  +G  C+D++EC  +
Sbjct: 1125 RPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGE 1183

Query: 2540 QHNCQF-LCVNTLGGFTCKCPPGF--TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFS 2596
            +H      C+N+ G F C C PGF   +  T+C D +EC +     G  G C NT GSF+
Sbjct: 1184 EHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVG--GHCVNTEGSFN 1241

Query: 2597 CECQRGFSLDATGLNCEDVDECD--GNHRC-QHGCQNILGGYRC--GCPQGYIQHYQWN- 2650
            C C+ GF        C D+DEC+  G+  C    C+N  G YRC  GC  G+  H   N 
Sbjct: 1242 CLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGF--HMAPNG 1299

Query: 2651 QCVDENECSNPNACGS-ASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYG 2709
             C+D +EC+N   CGS   C NT GS++C C  GF        C DVNEC      C   
Sbjct: 1300 DCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAA 1359

Query: 2710 -CSNTEGGYLCGCPPGY--YRVGQGHC-VSGMGFNKGQYLSLDTEVDEENALSPEACY 2763
             C N EG +LC C      Y   +GHC   G G   GQ +S     D   A +   CY
Sbjct: 1360 LCENVEGSFLCLCASDLEEYDAQEGHCRPRGAG---GQSMSEAPTGDHAPAPTRMDCY 1414



 Score =  347 bits (891), Expect = 8e-95
 Identities = 249/797 (31%), Positives = 341/797 (42%), Gaps = 96/797 (12%)

Query: 1988 GRCFNEIGSFKCLCNEGYELTPDGKNCIDTNEC--VALPGSCSPGTCQNLEGSFRCICPP 2045
            GRC+    + +C  N   ELT     C        V L   C P     +  + +  CP 
Sbjct: 552  GRCYLNTVNGQC-ANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQ 610

Query: 2046 GYE-VKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR---- 2100
            GY+ +   +C DINEC     +C    C NT G + C C PG +L  +  RC   +    
Sbjct: 611  GYKRLNLTHCQDINEC-LTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISM 669

Query: 2101 -QSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGH 2159
             Q  C+ +   G C++P A   TK  CCCS++ G+ WG  CE CP     AF+++CP GH
Sbjct: 670  LQGLCYRSLGPGTCTLPLAQRITKQICCCSRV-GKAWGSECEKCPLPGTEAFREICPAGH 728

Query: 2160 GTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSI 2219
            G   +  D R  + +  E        +     G  R    +    +   +R V       
Sbjct: 729  GYTYASSDIRLSMRKAEEE----ELARPPREQGQ-RSSGALPGPAERQPLRVVTDTWLEA 783

Query: 2220 G-------NPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTF 2272
            G       +  G  T +          N    P P     +I E    P       ++T 
Sbjct: 784  GTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTP 843

Query: 2273 GSYEC-----------TC---PIGY--------ALREDQKMCKDLDECAEGLHDCESRGM 2310
            G   C           TC   P GY         L   Q  C D +EC      C+ +G 
Sbjct: 844  GIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLR--DPCKGKG- 900

Query: 2311 MCKNLIGTFMCICPPGMARRPDG--EGCVDENECRTKPGICENGRCVNIIGSYRCECNEG 2368
             C N +G++ C C PG      G  + C D NEC  +PG+C  G+C N  GSY CEC++G
Sbjct: 901  RCINRVGSYSCFCYPGYTLATSGATQECQDINECE-QPGVCSGGQCTNTEGSYHCECDQG 959

Query: 2369 FQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLP 2428
            +     G                   CQ  +  R+  T    C DG      +C   P  
Sbjct: 960  YIMVRKGH------------------CQDINECRHPGT----CPDG------RCVNSPGS 991

Query: 2429 GTAQYKKICPHG-PGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGT 2487
             T      C  G  G +    D++EC + P +C +G+C N  GSFRC C+ GY       
Sbjct: 992  YTC---LACEEGYRGQSGSCVDVNEC-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEK 1047

Query: 2488 SCIDLDECSQSPKPCNYICKNTEGSYQCS-CPRGYVLQEDGKTCKDLDECQTKQHNCQFL 2546
             C D+DEC+        +C NTEGS+ CS C  GY + EDG  C+DLDEC         +
Sbjct: 1048 GCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGV 1107

Query: 2547 CVNTLGGFTCK-CPPGF--TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGF 2603
            C NT G F+CK C  G+  +    +C D +EC    S C   G C+NT GS+ C C +GF
Sbjct: 1108 CTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCLCPQGF 1166

Query: 2604 SLDATGLNCEDVDECDGNHRC-QHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNP 2661
             L A G  CEDV+EC G   C  HG C N  G + C C  G++       C D +EC+  
Sbjct: 1167 QL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATT 1225

Query: 2662 NACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPC--NYGCSNTEGGYLC 2719
            + C    C NT GS+ C C +GF     S  C D++EC    +P    + C N+ G Y C
Sbjct: 1226 DPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRC 1285

Query: 2720 --GCPPGYYRVGQGHCV 2734
              GC PG++    G C+
Sbjct: 1286 VLGCQPGFHMAPNGDCI 1302



 Score =  340 bits (873), Expect = 9e-93
 Identities = 261/875 (29%), Positives = 366/875 (41%), Gaps = 156/875 (17%)

Query: 134  SGQISSTCGSKSIQQCSVRCMN---GGTCAD----DHCQCQKGY----IGTYC--GQPVC 180
            S  +  T  +  I +C+    N    GTC +      C C  GY       YC       
Sbjct: 833  STDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECL 892

Query: 181  ENGCQNGGRCI---GPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKT 237
             + C+  GRCI   G   C C  G+T         T  C   +N     G  +G  CT T
Sbjct: 893  RDPCKGKGRCINRVGSYSCFCYPGYT---LATSGATQEC-QDINECEQPGVCSGGQCTNT 948

Query: 238  LCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVG 297
                       + CE        C +G+I  +R G CQD++EC+  PG C  G C+N+ G
Sbjct: 949  --------EGSYHCE--------CDQGYIM-VRKGHCQDINECRH-PGTCPDGRCVNSPG 990

Query: 298  SFEC-RCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGS 356
            S+ C  C  G++    +  C D++EC + PG+C  G+C+N  GS+ C C +GY  ++D  
Sbjct: 991  SYTCLACEEGYRGQSGS--CVDVNEC-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEK 1047

Query: 357  RCIDQR---------TGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPV 407
             C D           TG+C +   +  C+             CE G  + +     AC  
Sbjct: 1048 GCQDVDECASRASCPTGLCLNTEGSFACS------------ACENG--YWVNEDGTACED 1093

Query: 408  RGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGF 467
                 +  +C    P G    +AGS        G+ PS  G+          P       
Sbjct: 1094 LDECAFPGVC----PSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQ------ 1143

Query: 468  SPGVGGAGVGAGGQGPIIT--GLTILNQTI----DICKHHANLCLNGRCIPTVSSYRCEC 521
            S  +GG      G    +   G  + N T+    + C    +   +G C+ +  S+ C C
Sbjct: 1144 SSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLC 1203

Query: 522  NMGYKQDANG-DCIDVDEC-TSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDEC 579
              G+     G  C DVDEC T++PC  G CVNT GS+ C C  GFQ +P    C+DIDEC
Sbjct: 1204 APGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDEC 1263

Query: 580  IQNG-VLCKNGRCVNTDGSFQCI--CNAGFELTTDGKNCVDHDECTTTNMC-LNGMCINE 635
               G  +C   +C N+ GS++C+  C  GF +  +G +C+D DEC    MC  +G C N 
Sbjct: 1264 EDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGSHGFCDNT 1322

Query: 636  DGSFKCICKPGFVLAPNGRYCTDVDECQTP-GICMNGHCINSEGSFRCDCPPGLAV---- 690
            DGSF+C+C  GF ++P+G  C DV+EC+    +C    C N EGSF C C   L      
Sbjct: 1323 DGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQ 1382

Query: 691  -------GMDGRVCVDTHM--------RSTCYGGIK-KGVCVRPFPGAVTKSECCCANPD 734
                   G  G+   +           R  CY G K    C        T++ECCC    
Sbjct: 1383 EGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQ-G 1441

Query: 735  YGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCN 794
              +G+ C  CP+++SAEF  +C SG G                I   G     +  Y   
Sbjct: 1442 ASWGDACDLCPSEDSAEFSEICPSGKGY---------------IPVEGAWTFGQTMYT-- 1484

Query: 795  CNSGYEPDASGRNCIDIDECLV-NRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDI 853
                           D DEC++    LC NG C NT   Y C C PG+ +    + CED 
Sbjct: 1485 ---------------DADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDH 1529

Query: 854  NECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGT------------CWLN 901
            +EC+   C NG C N  GSF+C CSP   L  +   C++S   T            CW  
Sbjct: 1530 DECQDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKK 1589

Query: 902  IQDSRCEVNING-ATLKSECCATLGAAWGSPCERC 935
            + +  C   + G  T  +ECC   G AW   C  C
Sbjct: 1590 VTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALC 1624



 Score =  316 bits (810), Expect = 2e-85
 Identities = 237/766 (30%), Positives = 330/766 (43%), Gaps = 146/766 (19%)

Query: 2065 NICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKA 2124
            N+C  G+C N P G++C+C PG+ L  +   C D  +         G+C      N   +
Sbjct: 854  NVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRC-----INRVGS 908

Query: 2125 KCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTRE--DVNECLESPGIC 2182
              C                           C  G+ T+ +   T+E  D+NEC E PG+C
Sbjct: 909  YSC--------------------------FCYPGY-TLATSGATQECQDINEC-EQPGVC 940

Query: 2183 SNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFEC-NCNE 2241
            S GQC NT+GS+ CEC  GY +   G  C D +EC     C +G C N  GS+ C  C E
Sbjct: 941  SGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINECRHPGTCPDGRCVNSPGSYTCLACEE 999

Query: 2242 GFEPGPMMNCEDINECAQNPLLCAF-RCMNTFGSYECTCPIGYALREDQKMCKDLDECAE 2300
            G+  G   +C D+NEC   P +CA  +C N  GS+ C+C  GY +  D+K C+D+DECA 
Sbjct: 1000 GYR-GQSGSCVDVNECL-TPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECAS 1057

Query: 2301 GLHDCESRGMMCKNLIGTFMC-ICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIG 2359
                C +   +C N  G+F C  C  G     DG  C D +EC   PG+C +G C N  G
Sbjct: 1058 RA-SCPTG--LCLNTEGSFACSACENGYWVNEDGTACEDLDECAF-PGVCPSGVCTNTAG 1113

Query: 2360 SYRC-ECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGW 2418
            S+ C +C+ G++ S  G  C D  +     E  Q+ C +    +N V   +C C  G   
Sbjct: 1114 SFSCKDCDGGYRPSPLGDSCEDVDE----CEDPQSSC-LGGECKNTVGSYQCLCPQGFQL 1168

Query: 2419 GHQCELCPLPGTAQYKKIC-PHG--------------PGYT-----TDGRDIDECKVMPN 2458
             +   +C        ++ C PHG              PG+      T  +D+DEC    +
Sbjct: 1169 ANGT-VCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATT-D 1226

Query: 2459 LCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQC- 2515
             C  G C+NT GSF C C+ G+        C+D+DEC     P    + C+N+ GSY+C 
Sbjct: 1227 PCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCV 1286

Query: 2516 -SCPRGYVLQEDGKTCKDLDECQTKQH-NCQFLCVNTLGGFTCKCPPGFTQHHTA--CID 2571
              C  G+ +  +G  C D+DEC           C NT G F C C  GF    +   C+D
Sbjct: 1287 LGCQPGFHMAPNGD-CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVD 1345

Query: 2572 NNECGSQPSLCGAKGICQNTPGSFSCECQRGFS-LDATGLNC-------EDVDECD-GNH 2622
             NEC    ++CGA  +C+N  GSF C C       DA   +C       + + E   G+H
Sbjct: 1346 VNECELMLAVCGA-ALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDH 1404

Query: 2623 R-------CQHG------CQNILG----------------GYRCG-------------CP 2640
                    C  G      C ++LG                G  C              CP
Sbjct: 1405 APAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICP 1464

Query: 2641 --QGYIQ-----HYQWNQCVDENECS--NPNACGSASCYNTLGSYKCACPSGFSFDQFSS 2691
              +GYI       +      D +EC    P  C +  C NT+  Y C C  GF +D    
Sbjct: 1465 SGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHK 1524

Query: 2692 ACHDVNECSSSKNPCNYG-CSNTEGGYLCGC-PPGYYRVGQGHCVS 2735
             C D +EC      C  G C NTEG + C C PP    + Q  C++
Sbjct: 1525 KCEDHDECQDL--ACENGECVNTEGSFHCFCSPPLTLDLSQQRCMN 1568



 Score =  219 bits (558), Expect = 3e-56
 Identities = 222/827 (26%), Positives = 306/827 (37%), Gaps = 231/827 (27%)

Query: 80   QDVLRGPNVCGSRFHSYCC---PGWKTLPGGNQCIVPICRNSCGD-GFCSRPNMCTCSSG 135
            +D  +G   C +R  SY C   PG+     G           C D   C +P +C  S G
Sbjct: 893  RDPCKGKGRCINRVGSYSCFCYPGYTLATSG-------ATQECQDINECEQPGVC--SGG 943

Query: 136  QISSTCGS-------------KSIQQCSVRCMNGGTCADDHC----------QCQKGYIG 172
            Q ++T GS             K   Q    C + GTC D  C           C++GY G
Sbjct: 944  QCTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRG 1003

Query: 173  TYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQ---L 229
               G  V  N C   G C    +C  + G     CE+ Y         + + CQ      
Sbjct: 1004 Q-SGSCVDVNECLTPGVC-AHGKCTNLEGSFRCSCEQGYEVTS-----DEKGCQDVDECA 1056

Query: 230  TGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQG 289
            +   C   LC  T G         C A    C  G+  N    AC+D+DEC A PG+C  
Sbjct: 1057 SRASCPTGLCLNTEGSF------ACSA----CENGYWVNEDGTACEDLDEC-AFPGVCPS 1105

Query: 290  GNCINTVGSFECR-CPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRG 348
            G C NT GSF C+ C  G++ S     CED+DEC      C  GEC NTVGSY C+CP+G
Sbjct: 1106 GVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQG 1165

Query: 349  YVTSTDGSRCIDQRTGMCFSGLV-NGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPV 407
            +  + +G+ C D    M       +G C            C C PG              
Sbjct: 1166 FQLA-NGTVCEDVNECMGEEHCAPHGECLNS----HGSFFCLCAPGFV------------ 1208

Query: 408  RGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGF 467
              S E    C D      +   A + P   GG+     G+ N      TGF P P     
Sbjct: 1209 --SAEGGTSCQD------VDECATTDP-CVGGHCVNTEGSFNCLCE--TGFQPSP----- 1252

Query: 468  SPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHAN-LCLNGRCIPTVSSYRC--ECNMG 524
                          G  +         ID C+ + + +C   +C  +  SYRC   C  G
Sbjct: 1253 ------------ESGECV--------DIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPG 1292

Query: 525  YKQDANGDCIDVDECTSNPC--TNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQN 582
            +    NGDCID+DEC ++    ++G C NT GS+ C C  GF+ +P+   C+D++EC   
Sbjct: 1293 FHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELM 1352

Query: 583  GVLCKNGRCVNTDGSFQCICNAGF-ELTTDGKNC---------------VDHDECTTTNM 626
              +C    C N +GSF C+C +   E      +C                DH    T   
Sbjct: 1353 LAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMD 1412

Query: 627  CLNG---------------------------------MCINEDGS-FKCICKPGFVLAP- 651
            C +G                                 +C +ED + F  IC  G    P 
Sbjct: 1413 CYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPV 1472

Query: 652  NGRYC------TDVDECQT--PGICMN--------------------------------- 670
             G +       TD DEC    PG+C N                                 
Sbjct: 1473 EGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDEC 1532

Query: 671  -------GHCINSEGSFRCDCPPGLAVGMDGRVCV------------DTHMRSTCYGGIK 711
                   G C+N+EGSF C C P L + +  + C+            D HM   C+  + 
Sbjct: 1533 QDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHM-DICWKKVT 1591

Query: 712  KGVCVRPFPG-AVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCS 757
              VC  P  G   T +ECCC + +  + + C  CP ++S  +  LC+
Sbjct: 1592 NDVCSEPLRGHRTTYTECCCQDGE-AWSQQCALCPPRSSEVYAQLCN 1637



 Score =  179 bits (453), Expect = 5e-44
 Identities = 149/532 (28%), Positives = 203/532 (38%), Gaps = 76/532 (14%)

Query: 97   CCPGWKTLPGGNQCIVPICRNS--CGD-GFCSRPN---MCTCSSGQISSTCG--SKSIQQ 148
            C PG+   P G+   +  C N   CG  GFC   +    C C  G   S  G     + +
Sbjct: 1289 CQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNE 1348

Query: 149  CSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGG-RCIGPNRCACVYGFTGPQC 207
            C +       C    C+  +G     C   + E   Q G  R  G    +     TG   
Sbjct: 1349 CELML---AVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHA 1405

Query: 208  ERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQ-------P 260
                R      Q  +  C   L G   T+  CC T G +WG  C++CP++         P
Sbjct: 1406 PAPTRMDCYSGQKGHAPCSSVL-GRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICP 1464

Query: 261  CRRGFIP-----NIRTGACQDVDECQAI-PGICQGGNCINTVGSFECRCPAGHKQSETTQ 314
              +G+IP             D DEC    PG+C  G C+NTV  + C C  G     + +
Sbjct: 1465 SGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHK 1524

Query: 315  KCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCI------------DQR 362
            KCED DEC  +   CE GEC NT GS+ C C           RC+            D  
Sbjct: 1525 KCEDHDECQDL--ACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIH 1582

Query: 363  TGMCFSGLVNGRCAQELPG-RMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGL 421
              +C+  + N  C++ L G R T  +CCC+ G  W        CP R SE Y +LC    
Sbjct: 1583 MDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQC--ALCPPRSSEVYAQLCNVAR 1640

Query: 422  PMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGF--SPGVGGAGVGAG 479
                       RPG   G G     + + YGP G  F    G       P        + 
Sbjct: 1641 IEAEREAGVHFRPGYEYGPG-PDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSA 1699

Query: 480  GQGPIITGLTILNQTIDICKHHA---------------------NLCLNGRCIPTVSSYR 518
             + PI+       Q  ++  H+                      N C NGRC+     Y 
Sbjct: 1700 DRTPILESPL---QPSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYT 1756

Query: 519  CECNMGYKQD-ANGDCIDVDEC--TSNP---CTNGDCVNTPGSYYCKCHAGF 564
            C+C  G++ D A+  C+DV+EC   + P   C +G C NT GSY C C  G+
Sbjct: 1757 CDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGY 1808



 Score =  108 bits (269), Expect = 1e-22
 Identities = 72/230 (31%), Positives = 95/230 (41%), Gaps = 54/230 (23%)

Query: 1576 VGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWG-NPCETCPPVNSTEYYTLCP 1634
            +G CYL        +  C   +    ++  CC S+G  WG   C  CPP           
Sbjct: 551  LGRCYLN-----TVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPP----------- 594

Query: 1635 GGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDID 1694
                    P + ++E+                       Q ECPQGY     T  C+DI+
Sbjct: 595  -------RPASPVIEN----------------------GQLECPQGYKRLNLTH-CQDIN 624

Query: 1695 ECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMD-----MRKSFCYRSYNGTTC 1749
            EC    G+C    C NT G+Y C C P  M       C+      M +  CYRS    TC
Sbjct: 625  ECLTL-GLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTC 683

Query: 1750 ENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTF 1799
               L   +TK++CCC+  VGKAW   CE CP PGT  F+ IC    G+T+
Sbjct: 684  TLPLAQRITKQICCCS-RVGKAWGSECEKCPLPGTEAFREICPAGHGYTY 732



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 47/130 (36%), Positives = 67/130 (51%), Gaps = 14/130 (10%)

Query: 1517 CDDGYE-LDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNR 1575
            C  GY+ L+ T  +C DI+EC     C +  CVNT G Y C C P   L+P+   CV ++
Sbjct: 608  CPQGYKRLNLT--HCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665

Query: 1576 V-----GNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCS-LGKAWGNPCETCPPVNSTEY 1629
                  G CY   GP      +C   +   +++  CCCS +GKAWG+ CE CP   +  +
Sbjct: 666  AISMLQGLCYRSLGPG-----TCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAF 720

Query: 1630 YTLCPGGEGF 1639
              +CP G G+
Sbjct: 721  REICPAGHGY 730



 Score = 69.3 bits (168), Expect = 5e-11
 Identities = 35/84 (41%), Positives = 38/84 (45%), Gaps = 5/84 (5%)

Query: 2657 ECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNP---CNYG-CSN 2712
            EC   N C +  C      Y C C  GF  D    AC DVNEC     P   C +G C N
Sbjct: 1736 ECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCEN 1795

Query: 2713 TEGGYLCGCPPGYY-RVGQGHCVS 2735
            TEG Y C C PGY    G  HC +
Sbjct: 1796 TEGSYRCHCSPGYVAEAGPPHCTA 1819



 Score = 66.2 bits (160), Expect = 4e-10
 Identities = 44/116 (37%), Positives = 51/116 (43%), Gaps = 24/116 (20%)

Query: 39  RPQPPPQQVRSATAGSEGGFLAPEYR------------EEGAAVASRVRRRGQQDVLRGP 86
           R QPP Q  RS   G +    AP  R              GAA  +  R R     L G 
Sbjct: 114 RVQPPAQTRRSTPLGQQQP--APRTRAAPALPRLGTPQRSGAAPPTPPRGR-----LTGR 166

Query: 87  NVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCGD-GFCSRPNMCTCSSGQISSTC 141
           NVCG +    CCPGW T    N CI P+C   C + G CSRP +C C SG   + C
Sbjct: 167 NVCGGQ----CCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARC 218



 Score = 62.0 bits (149), Expect = 8e-09
 Identities = 27/74 (36%), Positives = 39/74 (52%), Gaps = 4/74 (5%)

Query: 1493 DECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECAD----PINCVNGLCV 1548
            +EC   N C  G C  +   + C C +G++LD     C D++EC D     + CV+G C 
Sbjct: 1735 EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCE 1794

Query: 1549 NTPGRYECNCPPDF 1562
            NT G Y C+C P +
Sbjct: 1795 NTEGSYRCHCSPGY 1808



 Score = 59.7 bits (143), Expect = 4e-08
 Identities = 31/79 (39%), Positives = 40/79 (50%), Gaps = 10/79 (12%)

Query: 2576 GSQPSLCGAKGICQN-----TPGSFSCECQRGFSLDATGLNCEDVDECDGNH----RCQH 2626
            G Q   CG    C+N         ++C+C  GF LDA  + C DV+ECD  +     C H
Sbjct: 1731 GLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVH 1790

Query: 2627 G-CQNILGGYRCGCPQGYI 2644
            G C+N  G YRC C  GY+
Sbjct: 1791 GYCENTEGSYRCHCSPGYV 1809



 Score = 53.5 bits (127), Expect = 3e-06
 Identities = 27/74 (36%), Positives = 37/74 (50%), Gaps = 5/74 (6%)

Query: 2616 DECDGNHRCQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNA----CGSASCY 2670
            +EC   + C++G C  +  GY C C +G+        CVD NEC + N     C    C 
Sbjct: 1735 EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCE 1794

Query: 2671 NTLGSYKCACPSGF 2684
            NT GSY+C C  G+
Sbjct: 1795 NTEGSYRCHCSPGY 1808



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 53/210 (25%), Positives = 76/210 (36%), Gaps = 57/210 (27%)

Query: 1740 CYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKP-CEPCPTPGTADFKTICGNIPGFT 1798
            CY +     C N L    T+  CC +  VG  W    C PCP                  
Sbjct: 554  CYLNTVNGQCANPLLELTTQEDCCGS--VGAFWGVTLCAPCPP----------------- 594

Query: 1799 FDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGD 1858
                          +    +  NG         + ECP G+   +L   C+DI+EC    
Sbjct: 595  --------------RPASPVIENG---------QLECPQGYKRLNLTH-CQDINECLTL- 629

Query: 1859 NLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCS-HGLCVDLQGSYQC 1917
             LC ++A+C+N+ GSY C C  G  L P+     R+ C+    +    GLC    G   C
Sbjct: 630  GLC-KDAECVNTRGSYLCTCRPGLMLDPS-----RSRCVSDKAISMLQGLCYRSLGPGTC 683

Query: 1918 ICHNGFKASQDQTMCMDV-----DECERHP 1942
                  + ++    C  V      ECE+ P
Sbjct: 684  TLPLAQRITKQICCCSRVGKAWGSECEKCP 713



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 24/60 (40%), Positives = 27/60 (45%), Gaps = 9/60 (15%)

Query: 149 CSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCE 208
           C  +C  G T A+    C K         PVCE  CQN G C  P  C C  GF G +CE
Sbjct: 169 CGGQCCPGWTTANSTNHCIK---------PVCEPPCQNRGSCSRPQLCVCRSGFRGARCE 219



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 29/113 (25%), Positives = 42/113 (37%), Gaps = 12/113 (10%)

Query: 1265 ECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCI 1324
            +  C +GY  + +   C DI+EC     +C   +C N  G Y C C  G M       C+
Sbjct: 605  QLECPQGYKRL-NLTHCQDINECLTL-GLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCV 662

Query: 1325 DVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDV-----DECE 1372
                  +     + G C  + G   C   L   + K    C+ V      ECE
Sbjct: 663  SDKAISM-----LQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECE 710



 Score = 37.0 bits (84), Expect = 0.29
 Identities = 20/52 (38%), Positives = 24/52 (46%), Gaps = 2/52 (3%)

Query: 1534 DECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGP 1585
            +EC     C NG CV     Y C+C   FQL+   + CVD  V  C    GP
Sbjct: 1735 EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVD--VNECDDLNGP 1784



 Score = 35.0 bits (79), Expect = 1.1
 Identities = 25/97 (25%), Positives = 33/97 (34%), Gaps = 2/97 (2%)

Query: 651  PNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGI 710
            P G      +EC     C NG C+     + CDC  G  +      CVD +      G  
Sbjct: 1726 PAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNG-- 1783

Query: 711  KKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAK 747
               +CV  +      S  C  +P Y        C AK
Sbjct: 1784 PAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAK 1820



 Score = 33.5 bits (75), Expect = 3.2
 Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 3/47 (6%)

Query: 1352 CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREG 1398
            C  GY  +   T C D++EC +    C   A C+N  GS+ C+CR G
Sbjct: 608  CPQGYK-RLNLTHCQDINEC-LTLGLCK-DAECVNTRGSYLCTCRPG 651


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score =  489 bits (1259), Expect = e-137
 Identities = 429/1425 (30%), Positives = 603/1425 (42%), Gaps = 264/1425 (18%)

Query: 1370 ECEIGAHNCDMHASCLNIP-GSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNT 1428
            +C  G   C     C+    G+  C C EG++G    C   D C    ++C     CV  
Sbjct: 27   QCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGE--YCQHRDPCEK--NRCQNGGTCVAQ 82

Query: 1429 P--GSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVP-GAYRCECEMGFTPASD 1485
               G   C C+ GFTG+    S    C  +      G C  +    Y C C++GFT    
Sbjct: 83   AMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFT---- 138

Query: 1486 SRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNC-TDIDECADPINCVN 1544
             + CQ  D C         TC  +   F C C  G+    TG  C TD++EC  P +C +
Sbjct: 139  GKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGF----TGQKCETDVNECDIPGHCQH 194

Query: 1545 G-LCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSR 1603
            G  C+N PG Y+C CP  F    TG  C      + Y+   P                  
Sbjct: 195  GGTCLNLPGSYQCQCPQGF----TGQYC-----DSLYVPCAP------------------ 227

Query: 1604 SSCCCSLGKAWGNPCETCPPVNSTEYYTLC-PGGEGFRPNPITIILEDIDECQELPGLCQ 1662
             S C + G        TC       +   C PG EG      +    +ID+C      CQ
Sbjct: 228  -SPCVNGG--------TCRQTGDFTFECNCLPGFEG------STCERNIDDCPN--HRCQ 270

Query: 1663 -GGNCINTFGSFQCECPQGYYLSEDTRIC-EDIDECFAHPGVC-GPGTCYNTLGNYTCIC 1719
             GG C++   ++ C CP  +      + C ED+DEC   P  C   GTC N  G Y C+C
Sbjct: 271  NGGVCVDGVNTYNCRCPPQW----TGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVC 326

Query: 1720 PPEYMQVNG--GHNCMDMRKSFCYRSYN-GTTCENELPFNVTKRMCCCTYNVGKAW---- 1772
                  VNG  G +C +      + S   G+TC +     V    C C    GKA     
Sbjct: 327  ------VNGWSGDDCSENIDDCAFASCTPGSTCIDR----VASFSCMCPE--GKAGLLCH 374

Query: 1773 -NKPC--EPCPTPGTADFKTICGNIPGFTFDIHTGK--AVDIDECKEI-PGICAN-GVCI 1825
             +  C   PC      D   + G         + G     D+DEC       C + G C+
Sbjct: 375  LDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCV 434

Query: 1826 NQIGSFRCECPTGFSYNDLLLVCE-DIDECSNGDNLCQRNADCINSPGSYRCECAAGFKL 1884
            N  G+F CEC  G++       CE DI+EC +    CQ +A C++  G + C C  GFK 
Sbjct: 435  NTDGAFHCECLKGYAGPR----CEMDINECHSDP--CQNDATCLDKIGGFTCLCMPGFK- 487

Query: 1885 SPNGAC-VDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPC 1943
                 C ++ NEC   P V ++G CVD    +QC+C  GF     Q   +D+D+C   PC
Sbjct: 488  --GVHCELEINECQSNPCV-NNGQCVDKVNRFQCLCPPGFTGPVCQ---IDIDDCSSTPC 541

Query: 1944 GNGT-CKNTVGSYNCLCYPGFE--LTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCL 2000
             NG  C +    Y C C  GF   L   N    ID C       C +G+C + I S+ C+
Sbjct: 542  LNGAKCIDHPNGYECQCATGFTGVLCEEN----IDNCDP---DPCHHGQCQDGIDSYTCI 594

Query: 2001 CNEGYELTPDGKNCIDT-NECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENC-IDIN 2058
            CN GY     G  C D  +EC + P   + G C +L   ++C C PG      NC I+ +
Sbjct: 595  CNPGYM----GAICSDQIDECYSSP-CLNDGRCIDLVNGYQCNCQPG--TSGVNCEINFD 647

Query: 2059 ECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKA 2118
            +C  +P  C+ G C +    + C+C PGF     G+RC          N +  +C+    
Sbjct: 648  DCASNP--CIHGICMDGINRYSCVCSPGFT----GQRC----------NIDIDECASNPC 691

Query: 2119 FNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLES 2178
                K   C + + G                 F+ +CP G    P        VNECL +
Sbjct: 692  ---RKGATCINGVNG-----------------FRCICPEG----PHHPSCYSQVNECLSN 727

Query: 2179 PGICSNGQCINTDGSFRCECPMGYNLDYTGVRC-VDTDECSIGNPCGNG-TCTNVIGSFE 2236
            P  C +G C      ++C C  G+     G+ C VD +EC + NPC NG TC N++  + 
Sbjct: 728  P--CIHGNCTGGLSGYKCLCDAGW----VGINCEVDKNEC-LSNPCQNGGTCDNLVNGYR 780

Query: 2237 CNCNEGFEPGPMMNCE-DINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDL 2295
            C C +GF+     NC+ +I+ECA NP L    C +    Y C C + Y  +  Q +   L
Sbjct: 781  CTCKKGFKG---YNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTV---L 834

Query: 2296 DECAEGLHDCESRGMMCKNL--IGTFMCICPPGMARRPDGEGC-VDENECRTKPGICEN- 2351
              C+   + CE+  + CK      ++ C+C PG      G+ C +D +EC +KP  C N 
Sbjct: 835  APCSP--NPCENAAV-CKESPNFESYTCLCAPGW----QGQRCTIDIDECISKP--CMNH 885

Query: 2352 GRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECC 2411
            G C N  GSY CEC  GF    SG +C ++       + L   CQ   S  + V    C 
Sbjct: 886  GLCHNTQGSYMCECPPGF----SGMDCEED-----IDDCLANPCQNGGSCMDGVNTFSCL 936

Query: 2412 CDGGRGWGHQC---------ELCPLPGTAQ-----YKKICPHGPGYTTDGRDIDECKVMP 2457
            C  G   G +C         E C   GT       Y   C  G        +I+EC    
Sbjct: 937  CLPGFT-GDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECT--E 993

Query: 2458 NLCTNG-QCINTMGSFRCFCKVGYTTDISGTSCI-DLDECSQSPKPCNYICKNTEGSYQC 2515
            + C NG  C++ + SF C C VG+T    G+ C+ +++ECS  P      C +  G+Y+C
Sbjct: 994  SSCFNGGTCVDGINSFSCLCPVGFT----GSFCLHEINECSSHPCLNEGTCVDGLGTYRC 1049

Query: 2516 SCPRGYVLQEDGKTCKDL-DECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNE 2574
            SCP GY     GK C+ L + C       +  CV       C CP G+   +   + N  
Sbjct: 1050 SCPLGYT----GKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCD-VPNVS 1104

Query: 2575 CGSQPS--------LCGAKGICQNTPGSFSCECQRGFSLDATGLNCED-VDECDGNHRCQ 2625
            C    S        LC   G+C N   +  C+C  G+    TG  CE+ +DEC  N  CQ
Sbjct: 1105 CDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGY----TGSYCEEQLDECASNP-CQ 1159

Query: 2626 HG--CQNILGGYRCGCPQGYIQHYQWNQCVDE-NECSNPNACGSASCYNTLGSYKCACPS 2682
            HG  C + +GGYRC C  GY    Q   C  E +EC N       +C + +  +KC+CP 
Sbjct: 1160 HGATCSDFIGGYRCECVPGY----QGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPP 1215

Query: 2683 GFSFDQFSSACHD-VNECSSSKNPCNYG-CSNTEGGYLCGCPPGY 2725
            G         C + +++C+   +  N G C +  GGY C C PG+
Sbjct: 1216 GTR----GLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGF 1256



 Score =  468 bits (1203), Expect = e-131
 Identities = 439/1521 (28%), Positives = 628/1521 (41%), Gaps = 329/1521 (21%)

Query: 153  CMNGGTCADDH-----CQCQKGYIGTYCGQ--PVCENGCQNGGRCI-----GPNRCACVY 200
            C+N G C   H     C+C +G++G YC    P  +N CQNGG C+     G   C C  
Sbjct: 35   CVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCAS 94

Query: 201  GFTGPQCERDYRTG-PCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQ 259
            GFTG  C+  Y T  PCF  V+     G    ++   T  C                   
Sbjct: 95   GFTGEDCQ--YSTSHPCF--VSRPCLNGGTCHMLSRDTYECT------------------ 132

Query: 260  PCRRGFIPNIRTGA-CQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCE- 317
             C+ GF     TG  CQ  D C + P    G  C      F C+C  G     T QKCE 
Sbjct: 133  -CQVGF-----TGKECQWTDACLSHP-CANGSTCTTVANQFSCKCLTGF----TGQKCET 181

Query: 318  DIDECSIIPGICETG-ECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCA 376
            D++EC I PG C+ G  C N  GSY C CP+G+      S  +      C +G   G C 
Sbjct: 182  DVNECDI-PGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNG---GTCR 237

Query: 377  QELPGRMTKMQCCCEPG----------------RCW-------GIGTIPEACPVRGSEEY 413
            Q   G  T  +C C PG                RC        G+ T    CP + + ++
Sbjct: 238  QT--GDFT-FECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQF 294

Query: 414  RRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGG 473
               C + +    +  +A  + GGT  N             GG G + + G +G       
Sbjct: 295  ---CTEDVDECLLQPNA-CQNGGTCANR-----------NGGYGCVCVNGWSGDD----- 334

Query: 474  AGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDC 533
                              ++ ID C   A+      CI  V+S+ C C  G    A   C
Sbjct: 335  -----------------CSENIDDCAF-ASCTPGSTCIDRVASFSCMCPEG---KAGLLC 373

Query: 534  IDVDECTSNPCTNGDCVNTP---GSYYCKCHAGFQRTPTKQACIDIDEC-IQNGVLCKN- 588
               D C SNPC  G   +T    G Y C C  G++     +   D+DEC + N   C++ 
Sbjct: 374  HLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTE---DVDECAMANSNPCEHA 430

Query: 589  GRCVNTDGSFQCICNAGFELTTDGKNC-VDHDECTTTNMCLNGMCINEDGSFKCICKPGF 647
            G+CVNTDG+F C C  G+     G  C +D +EC +     +  C+++ G F C+C PGF
Sbjct: 431  GKCVNTDGAFHCECLKGYA----GPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGF 486

Query: 648  VLAPNGRYCT-DVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVC---VDTHMR 703
                 G +C  +++ECQ+     NG C++    F+C CPPG      G VC   +D    
Sbjct: 487  ----KGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFT----GPVCQIDIDDCSS 538

Query: 704  STCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGIT 763
            + C  G K                 C  +P+   G  CQ             C++G    
Sbjct: 539  TPCLNGAK-----------------CIDHPN---GYECQ-------------CATGFTGV 565

Query: 764  VDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCID-IDECLVNRLLCD 822
            +   +I+ C  DPD C +G C++   SY C CN GY     G  C D IDEC  +  L D
Sbjct: 566  LCEENIDNC--DPDPCHHGQCQDGIDSYTCICNPGY----MGAICSDQIDECYSSPCLND 619

Query: 823  NGLCRNTPGSYSCTCPPGYVFRTETETCE-DINECESNPCVNGACRNNLGSFNCECSPGS 881
             G C +    Y C C PG    T    CE + ++C SNPC++G C + +  ++C CSPG 
Sbjct: 620  -GRCIDLVNGYQCNCQPG----TSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPG- 673

Query: 882  KLSSTGLIC---IDSL------KG-TCWLNIQDSRCEVNINGATLKSECCATLGAAWGSP 931
                TG  C   ID        KG TC   +   RC +   G    S C + +     +P
Sbjct: 674  ---FTGQRCNIDIDECASNPCRKGATCINGVNGFRC-ICPEGPHHPS-CYSQVNECLSNP 728

Query: 932  CERCELDTACPRGLARIK--------GVTCE-DVNECEVFPGVCPN-GRCVNSKGSFHCE 981
            C    +   C  GL+  K        G+ CE D NEC   P  C N G C N    + C 
Sbjct: 729  C----IHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNP--CQNGGTCDNLVNGYRCT 782

Query: 982  CPEGLTLDGTGRVCLDIRMEQCY-------------LKWDEDECIHPVPGKFRMDACCCA 1028
            C +G      G  C  + +++C              +      C+ P  GK     C   
Sbjct: 783  CKKGF----KGYNC-QVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGK----NCQTV 833

Query: 1029 VGAAWGTECEEC----PKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMC 1084
            +       CE        P  + Y  LC  G           G+    DI+EC + P M 
Sbjct: 834  LAPCSPNPCENAAVCKESPNFESYTCLCAPG---------WQGQRCTIDIDECISKPCM- 883

Query: 1085 TYGKCRNTIGSFKCRCNSGFA-LDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECF 1143
             +G C NT GS+ C C  GF+ +D EE    DID+C  +P   G G C++   +F C C 
Sbjct: 884  NHGLCHNTQGSYMCECPPGFSGMDCEE----DIDDCLANPCQNG-GSCMDGVNTFSCLCL 938

Query: 1144 EGYESGFMMMKNCMDIDECERNPLLCR-GGTCVNTEGSFQCDCPLGHELSPSREDCVDIN 1202
             G+       K   D++EC   P  C+ GGTC +   S+ C C  G +         +IN
Sbjct: 939  PGFTGD----KCQTDMNECLSEP--CKNGGTCSDYVNSYTCKCQAGFDGVHCEN---NIN 989

Query: 1203 ECSLSDNLCRN-GKCVNMIGTYQCSCNPGYQATPDRQGCT-DIDECMIMNGGCDTQCTNS 1260
            EC  +++ C N G CV+ I ++ C C  G+  +     C  +I+EC       +  C + 
Sbjct: 990  EC--TESSCFNGGTCVDGINSFSCLCPVGFTGS----FCLHEINECSSHPCLNEGTCVDG 1043

Query: 1261 EGSYECSCSEGYALMPDGRSCAD-IDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMD 1319
             G+Y CSC  GY     G++C   ++ C  +P   + G C     E +CLC  G+  +  
Sbjct: 1044 LGTYRCSCPLGYT----GKNCQTLVNLCSRSP-CKNKGTCVQKKAESQCLCPSGWAGAY- 1097

Query: 1320 MKTCIDVN-ECD--------LNSNICMF-GECENTKGSFICHCQLGYSVKKGTTGCTDVD 1369
               C   N  CD        L  ++C   G C N   +  C C LGY+   G+     +D
Sbjct: 1098 ---CDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYT---GSYCEEQLD 1151

Query: 1370 ECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKC-IDLDECSNGTHQCSINAQCVNT 1428
            EC   ++ C   A+C +  G ++C C  G+   G+ C  ++DEC N    C     C++ 
Sbjct: 1152 EC--ASNPCQHGATCSDFIGGYRCECVPGY--QGVNCEYEVDECQN--QPCQNGGTCIDL 1205

Query: 1429 PGSYRCACSEGFTGDGFTCSD-VDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSR 1487
               ++C+C  G    G  C + +D+CA   +    GQC++  G Y C C  GF   +  R
Sbjct: 1206 VNHFKCSCPPGTR--GLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGF---AGER 1260

Query: 1488 SCQDIDECSFQNICVFGT--CNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNG 1545
               DI+EC        G+  C  L   + C+C   +    TG +C    +    + C+NG
Sbjct: 1261 CEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAF----TGRHCETFVDVCPQMPCLNG 1316

Query: 1546 ----LCVNTPGRYECNCPPDF 1562
                +  N P  + C CPP F
Sbjct: 1317 GTCAVASNMPDGFICRCPPGF 1337



 Score =  456 bits (1172), Expect = e-127
 Identities = 455/1639 (27%), Positives = 662/1639 (40%), Gaps = 339/1639 (20%)

Query: 586  CKN-GRCVNT-DGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNG-MCINED--GSFK 640
            C N G CV   +G+  C C  GF     G+ C   D C   N C NG  C+ +   G   
Sbjct: 35   CVNEGMCVTYHNGTGYCKCPEGFL----GEYCQHRDPCEK-NRCQNGGTCVAQAMLGKAT 89

Query: 641  CICKPGFVLAPNGRYCTDVDECQTPGICMNGHCIN--SEGSFRCDCPPGLAVGMDGRVC- 697
            C C  GF    + +Y T    C     C+NG   +  S  ++ C C     VG  G+ C 
Sbjct: 90   CRCASGFT-GEDCQYSTS-HPCFVSRPCLNGGTCHMLSRDTYECTCQ----VGFTGKECQ 143

Query: 698  -VDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGF-GEPCQPCPAKNSAEFHGL 755
              D  +   C  G         F        C C     GF G+ C+             
Sbjct: 144  WTDACLSHPCANGSTCTTVANQF-------SCKCLT---GFTGQKCET------------ 181

Query: 756  CSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL 815
                        D+NEC +       G C NL GSY+C C  G+    +G+ C  +    
Sbjct: 182  ------------DVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF----TGQYCDSLYVPC 225

Query: 816  VNRLLCDNGLCRNTPG-SYSCTCPPGYVFRTETETCE-DINECESNPCVN-GACRNNLGS 872
                  + G CR T   ++ C C PG+    E  TCE +I++C ++ C N G C + + +
Sbjct: 226  APSPCVNGGTCRQTGDFTFECNCLPGF----EGSTCERNIDDCPNHRCQNGGVCVDGVNT 281

Query: 873  FNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPC 932
            +NC C P      TG  C + +   C L  Q + C+   NG T     CA     +G  C
Sbjct: 282  YNCRCPP----QWTGQFCTEDV-DECLL--QPNACQ---NGGT-----CANRNGGYGCVC 326

Query: 933  ERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTG 992
                    C            E++++C  F    P   C++   SF C CPEG      G
Sbjct: 327  VNGWSGDDC-----------SENIDDC-AFASCTPGSTCIDRVASFSCMCPEG----KAG 370

Query: 993  RVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLC 1052
             +C                          +D  C +     G  C+  P  G  +Y   C
Sbjct: 371  LLC-------------------------HLDDACISNPCHKGALCDTNPLNG--QYICTC 403

Query: 1053 PRGAGFANRGDVLTGRPFYKDINEC-KAFPGMCTY-GKCRNTIGSFKCRCNSGFALDMEE 1110
            P+G           G    +D++EC  A    C + GKC NT G+F C C  G+A     
Sbjct: 404  PQG---------YKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYA---GP 451

Query: 1111 RNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNC-MDIDECERNPLLC 1169
            R   DI+EC   P       C++  G F C C  G++       +C ++I+EC+ NP + 
Sbjct: 452  RCEMDINECHSDP-CQNDATCLDKIGGFTCLCMPGFKG-----VHCELEINECQSNPCV- 504

Query: 1170 RGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNG-KCVNMIGTYQCSCN 1228
              G CV+    FQC CP G      +   +DI++CS +   C NG KC++    Y+C C 
Sbjct: 505  NNGQCVDKVNRFQCLCPPGFTGPVCQ---IDIDDCSSTP--CLNGAKCIDHPNGYECQCA 559

Query: 1229 PGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCAD-IDEC 1287
             G+      +   + D     +G    QC +   SY C C+ GY     G  C+D IDEC
Sbjct: 560  TGFTGVLCEENIDNCDPDPCHHG----QCQDGIDSYTCICNPGYM----GAICSDQIDEC 611

Query: 1288 ENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGS 1347
             ++P + D G+C ++   Y+C C  G           ++N  D  SN C+ G C +    
Sbjct: 612  YSSPCLND-GRCIDLVNGYQCNCQPGTSG-----VNCEINFDDCASNPCIHGICMDGINR 665

Query: 1348 FICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCRE---------- 1397
            + C C  G++   G     D+DEC   ++ C   A+C+N    F+C C E          
Sbjct: 666  YSCVCSPGFT---GQRCNIDIDEC--ASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQ 720

Query: 1398 ---------------------------GWIGNGIKC-IDLDECSNGTHQCSINAQCVNTP 1429
                                       GW+  GI C +D +EC   ++ C     C N  
Sbjct: 721  VNECLSNPCIHGNCTGGLSGYKCLCDAGWV--GINCEVDKNECL--SNPCQNGGTCDNLV 776

Query: 1430 GSYRCACSEGFTGDGFTCS-DVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRS 1488
              YRC C +GF   G+ C  ++DECA N  L   G C +    Y C C + +T     ++
Sbjct: 777  NGYRCTCKKGF--KGYNCQVNIDECASNPCL-NQGTCFDDISGYTCHCVLPYT----GKN 829

Query: 1489 CQDIDECSFQNICV-FGTCNNLPGM--FHCICDDGYELDRTGGNCT-DIDECADPINCVN 1544
            CQ +      N C     C   P    + C+C  G++    G  CT DIDEC       +
Sbjct: 830  CQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQ----GQRCTIDIDECISKPCMNH 885

Query: 1545 GLCVNTPGRYECNCPPDFQLNPTGVGC---VDNRVGNCYLKFGPRGDGSLSCNTEIGVGV 1601
            GLC NT G Y C CPP F    +G+ C   +D+ + N     G   DG  + +     G 
Sbjct: 886  GLCHNTQGSYMCECPPGF----SGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGF 941

Query: 1602 SRSSCCCSLGKAWGNPCE---TCPP-VNSTEYYTLCPGG-EGFRPNPITIILEDIDECQE 1656
            +   C   + +    PC+   TC   VNS  Y   C  G +G           +I+EC E
Sbjct: 942  TGDKCQTDMNECLSEPCKNGGTCSDYVNS--YTCKCQAGFDGVHCE------NNINECTE 993

Query: 1657 LPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYT 1716
                  GG C++   SF C CP G+     +    +I+EC +HP     GTC + LG Y 
Sbjct: 994  -SSCFNGGTCVDGINSFSCLCPVGF---TGSFCLHEINECSSHP-CLNEGTCVDGLGTYR 1048

Query: 1717 CICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPC 1776
            C CP  Y     G NC  +  + C RS     C+N       K  C     V K     C
Sbjct: 1049 CSCPLGYT----GKNCQTL-VNLCSRS----PCKN-------KGTC-----VQKKAESQC 1087

Query: 1777 EPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDE--CKEIPGICANGVCINQIGSFRCE 1834
              CP+     +   C ++P  + DI   +   + E  C+       +GVCIN   +  C+
Sbjct: 1088 -LCPSGWAGAY---C-DVPNVSCDIAASRRGVLVEHLCQH------SGVCINAGNTHYCQ 1136

Query: 1835 CPTGFSYNDLLLVCED-IDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDR 1893
            CP G++ +     CE+ +DEC++  N CQ  A C +  G YRCEC  G++       VD 
Sbjct: 1137 CPLGYTGS----YCEEQLDECAS--NPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVD- 1189

Query: 1894 NECLEIPNVCSH-GLCVDLQGSYQCICHNGFKASQDQTMCMD-VDECERHP-CGN-GTCK 1949
             EC   P  C + G C+DL   ++C C  G +      +C + +D+C R P C N G C 
Sbjct: 1190 -ECQNQP--CQNGGTCIDLVNHFKCSCPPGTRG----LLCEENIDDCARGPHCLNGGQCM 1242

Query: 1950 NTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTP 2009
            + +G Y+C C PGF         DI+EC S       +  C      + C+C   +    
Sbjct: 1243 DRIGGYSCRCLPGFAGERCEG--DINECLSNPCSSEGSLDCIQLTNDYLCVCRSAF---- 1296

Query: 2010 DGKNC-IDTNECVALPGSCSPGTC---QNLEGSFRCICPPGYE-VKSENCIDINECDEDP 2064
             G++C    + C  +P   + GTC    N+   F C CPPG+   + ++     +C +  
Sbjct: 1297 TGRHCETFVDVCPQMP-CLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGE 1355

Query: 2065 NICLFGSCTNTPGGFQCLCP------PGFVLS--DNGRRCFDTRQ-----SFCFTNFENG 2111
                   C +T  G +C CP       G   S   +G  C   RQ       C   F   
Sbjct: 1356 ------QCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGS 1409

Query: 2112 KCSVPKAFNTTKAKCCCSK 2130
            +C +  A  +T    C S+
Sbjct: 1410 RCELYTAPPSTPPATCLSQ 1428



 Score =  455 bits (1170), Expect = e-127
 Identities = 426/1471 (28%), Positives = 622/1471 (42%), Gaps = 303/1471 (20%)

Query: 790  SYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETET 849
            ++   C  GYEP      C++   C+               G+  C CP G++     E 
Sbjct: 23   AHALQCRDGYEP------CVNEGMCVTYH-----------NGTGYCKCPEGFL----GEY 61

Query: 850  CEDINECESNPCVNGA---CRNNLGSFNCECSPGSKLS----STGLICIDSLK----GTC 898
            C+  + CE N C NG     +  LG   C C+ G        ST   C  S      GTC
Sbjct: 62   CQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC 121

Query: 899  WLNIQDS---RCEVNINGATLK-SECCATLGAAWGSPCERCELDTACPRGLARIKGVTCE 954
             +  +D+    C+V   G   + ++ C +   A GS C       +C + L    G  CE
Sbjct: 122  HMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSC-KCLTGFTGQKCE 180

Query: 955  -DVNECEVFPGVCPNG-RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDEC 1012
             DVNEC++ PG C +G  C+N  GS+ C+CP+G     TG+ C     +  Y+      C
Sbjct: 181  TDVNECDI-PGHCQHGGTCLNLPGSYQCQCPQGF----TGQYC-----DSLYVPCAPSPC 230

Query: 1013 IH----PVPGKFRMDACCCAVGAAWGTECE----ECPK----------PGTKEYETLCPR 1054
            ++       G F  + C C  G   G+ CE    +CP            G   Y   CP 
Sbjct: 231  VNGGTCRQTGDFTFE-CNCLPGFE-GSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCP- 287

Query: 1055 GAGFANRGDVLTGRPFYKDINECKAFPGMC-TYGKCRNTIGSFKCRCNSGFALDMEERNC 1113
                       TG+   +D++EC   P  C   G C N  G + C C +G++ D    +C
Sbjct: 288  --------PQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGD----DC 335

Query: 1114 TD-IDECRISPDLCGSGICVNTPGSFECECFEGYESGFM-------MMKNCMDIDECERN 1165
            ++ ID+C  +    GS  C++   SF C C EG ++G +       +   C     C+ N
Sbjct: 336  SENIDDCAFASCTPGS-TCIDRVASFSCMCPEG-KAGLLCHLDDACISNPCHKGALCDTN 393

Query: 1166 PL----LC---------------------------RGGTCVNTEGSFQCDCPLGHELSPS 1194
            PL    +C                             G CVNT+G+F C+C  G+   P 
Sbjct: 394  PLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGY-AGPR 452

Query: 1195 REDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD 1254
             E  +DINEC  SD    +  C++ IG + C C PG++         +I+EC       +
Sbjct: 453  CE--MDINECH-SDPCQNDATCLDKIGGFTCLCMPGFKGVHCE---LEINECQSNPCVNN 506

Query: 1255 TQCTNSEGSYECSCSEGYALMPDGRSC-ADIDECENNPDICDGGQCTNIPGEYRCLCYDG 1313
             QC +    ++C C  G+     G  C  DID+C + P + +G +C + P  Y C C  G
Sbjct: 507  GQCVDKVNRFQCLCPPGFT----GPVCQIDIDDCSSTPCL-NGAKCIDHPNGYECQCATG 561

Query: 1314 FMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEI 1373
            F   +  +   +++ CD   + C  G+C++   S+ C C  GY    G      +DEC  
Sbjct: 562  FTGVLCEE---NIDNCD--PDPCHHGQCQDGIDSYTCICNPGY---MGAICSDQIDECY- 612

Query: 1374 GAHNCDMHASCLNIPGSFKCSCREGWIGNGIKC-IDLDECSNGTHQCSINAQCVNTPGSY 1432
             +  C     C+++   ++C+C+ G   +G+ C I+ D+C++      I+  C++    Y
Sbjct: 613  -SSPCLNDGRCIDLVNGYQCNCQPG--TSGVNCEINFDDCASNP---CIHGICMDGINRY 666

Query: 1433 RCACSEGFTGDGFTCS-DVDECAENINLCENG-QCLNVPGAYRCECEMGFTPASDSRSC- 1489
             C CS GFTG    C+ D+DECA   N C  G  C+N    +RC C  G        SC 
Sbjct: 667  SCVCSPGFTGQ--RCNIDIDECAS--NPCRKGATCINGVNGFRCICPEG----PHHPSCY 718

Query: 1490 QDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNC-TDIDECADPINCVNGLCV 1548
              ++EC   N C+ G C      + C+CD G+     G NC  D +EC        G C 
Sbjct: 719  SQVNEC-LSNPCIHGNCTGGLSGYKCLCDAGW----VGINCEVDKNECLSNPCQNGGTCD 773

Query: 1549 NTPGRYECNCPPDFQLNPTGVGC---VDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSS 1605
            N    Y C C   F+    G  C   +D    N  L  G   D          +  +  +
Sbjct: 774  NLVNGYRCTCKKGFK----GYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKN 829

Query: 1606 CCCSLGKAWGNPCE---TCPPVNSTEYYT-LC-PGGEGFRPNPITIILEDIDECQELPGL 1660
            C   L     NPCE    C    + E YT LC PG +G R    TI   DIDEC   P +
Sbjct: 830  CQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQR---CTI---DIDECISKPCM 883

Query: 1661 CQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICP 1720
               G C NT GS+ CECP G+         EDID+C A+P   G G+C + +  ++C+C 
Sbjct: 884  -NHGLCHNTQGSYMCECPPGF---SGMDCEEDIDDCLANPCQNG-GSCMDGVNTFSCLCL 938

Query: 1721 PEYMQVNGGHNCM-DMRKSFCYRSYNGTTCENELPFNVTKRMC-----CCTYNVGKAWNK 1774
            P +     G  C  DM +       NG TC + +     K         C  N+ +    
Sbjct: 939  PGFT----GDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTES 994

Query: 1775 PCEPCPT--PGTADFKTICGNIPGFT--FDIHTGKAVDIDECKEIPGICAN-GVCINQIG 1829
             C    T   G   F  +C    GFT  F +H     +I+EC   P  C N G C++ +G
Sbjct: 995  SCFNGGTCVDGINSFSCLCP--VGFTGSFCLH-----EINECSSHP--CLNEGTCVDGLG 1045

Query: 1830 SFRCECPTGF----------------------------------------SYNDLLLVCE 1849
            ++RC CP G+                                        +Y D+  V  
Sbjct: 1046 TYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSC 1105

Query: 1850 DIDECSNG---DNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDR-NECLEIPNVCSH 1905
            DI     G   ++LCQ +  CIN+  ++ C+C  G+       C ++ +EC    N C H
Sbjct: 1106 DIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGY---TGSYCEEQLDECAS--NPCQH 1160

Query: 1906 G-LCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGN-GTCKNTVGSYNCLCYPGF 1963
            G  C D  G Y+C C  G++    +    +VDEC+  PC N GTC + V  + C C PG 
Sbjct: 1161 GATCSDFIGGYRCECVPGYQGVNCE---YEVDECQNQPCQNGGTCIDLVNHFKCSCPPG- 1216

Query: 1964 ELTHNNDCLD-IDECSSFFGQVCRN-GRCFNEIGSFKCLCNEGYELTPDGKNCI-DTNEC 2020
              T    C + ID+C+   G  C N G+C + IG + C C  G+     G+ C  D NEC
Sbjct: 1217 --TRGLLCEENIDDCAR--GPHCLNGGQCMDRIGGYSCRCLPGFA----GERCEGDINEC 1268

Query: 2021 VALPGSCSPGT--CQNLEGSFRCICPPGYEVK-SENCIDINECDEDPNICLFGS----CT 2073
            ++ P S S G+  C  L   + C+C   +  +  E  +D+  C + P  CL G      +
Sbjct: 1269 LSNPCS-SEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDV--CPQMP--CLNGGTCAVAS 1323

Query: 2074 NTPGGFQCLCPPGFVLSDNGRRCFDTRQSFC 2104
            N P GF C CPPGF    +G RC    QS C
Sbjct: 1324 NMPDGFICRCPPGF----SGARC----QSSC 1346



 Score =  446 bits (1148), Expect = e-124
 Identities = 448/1595 (28%), Positives = 633/1595 (39%), Gaps = 342/1595 (21%)

Query: 1095 SFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMK 1154
            +++C C  GF      + C   D C   P   GS  C      F C+C     +GF   K
Sbjct: 128  TYECTCQVGFT----GKECQWTDACLSHPCANGS-TCTTVANQFSCKCL----TGFTGQK 178

Query: 1155 NCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE--------LSPSREDCVDINEC-- 1204
               D++EC+       GGTC+N  GS+QC CP G          +  +   CV+   C  
Sbjct: 179  CETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQ 238

Query: 1205 ------------------------SLSDNLCRN-GKCVNMIGTYQCSCNPGYQATPDRQG 1239
                                       ++ C+N G CV+ + TY C C P +      Q 
Sbjct: 239  TGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTG----QF 294

Query: 1240 CT-DIDECMIMNGGCDT--QCTNSEGSYECSCSEGYA----------------------- 1273
            CT D+DEC++    C     C N  G Y C C  G++                       
Sbjct: 295  CTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCI 354

Query: 1274 --------LMPDGRS---CADIDECENNPDICDGGQCTNIP--GEYRCLCYDGFMASMDM 1320
                    + P+G++   C   D C +NP    G  C   P  G+Y C C  G+  +   
Sbjct: 355  DRVASFSCMCPEGKAGLLCHLDDACISNP-CHKGALCDTNPLNGQYICTCPQGYKGA--- 410

Query: 1321 KTCIDVNECDL-NSNICMF-GECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNC 1378
                DV+EC + NSN C   G+C NT G+F C C  GY+   G     D++EC   +  C
Sbjct: 411  DCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYA---GPRCEMDINECH--SDPC 465

Query: 1379 DMHASCLNIPGSFKCSCREGWIGNGIKC-IDLDECSNGTHQCSINAQCVNTPGSYRCACS 1437
               A+CL+  G F C C  G+   G+ C ++++EC   ++ C  N QCV+    ++C C 
Sbjct: 466  QNDATCLDKIGGFTCLCMPGF--KGVHCELEINECQ--SNPCVNNGQCVDKVNRFQCLCP 521

Query: 1438 EGFTGDGFTCS-DVDECAENINLCENG-QCLNVPGAYRCECEMGFTPASDSRSCQDIDEC 1495
             GFTG    C  D+D+C+     C NG +C++ P  Y C+C  GFT        ++ID C
Sbjct: 522  PGFTGP--VCQIDIDDCSS--TPCLNGAKCIDHPNGYECQCATGFTGVLCE---ENIDNC 574

Query: 1496 SFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTD-IDECADPINCVNGLCVNTPGRY 1554
               + C  G C +    + CIC+ GY     G  C+D IDEC       +G C++    Y
Sbjct: 575  D-PDPCHHGQCQDGIDSYTCICNPGY----MGAICSDQIDECYSSPCLNDGRCIDLVNGY 629

Query: 1555 ECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGV-GVSRSSCCCSLG-- 1611
            +CNC P      +GV C  N   +C          S  C   I + G++R SC CS G  
Sbjct: 630  QCNCQP----GTSGVNCEIN-FDDC---------ASNPCIHGICMDGINRYSCVCSPGFT 675

Query: 1612 ---------KAWGNPCE---TCPPVNSTE-YYTLCPGGEGFRPNPITIILEDIDECQELP 1658
                     +   NPC    TC  +N    +  +CP G    P+        ++EC   P
Sbjct: 676  GQRCNIDIDECASNPCRKGATC--INGVNGFRCICPEGP-HHPS----CYSQVNECLSNP 728

Query: 1659 GLCQGGNCINTFGSFQCECPQGYYLSEDTRICE-DIDECFAHPGVCGPGTCYNTLGNYTC 1717
              C  GNC      ++C C  G+        CE D +EC ++P   G GTC N +  Y C
Sbjct: 729  --CIHGNCTGGLSGYKCLCDAGWVGIN----CEVDKNECLSNPCQNG-GTCDNLVNGYRC 781

Query: 1718 ICPPEYMQVNGGHNCM----------DMRKSFCYRSYNGTTCENELPF---NVTKRMCCC 1764
             C   +     G+NC            + +  C+   +G TC   LP+   N    +  C
Sbjct: 782  TCKKGFK----GYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPC 837

Query: 1765 TYNVGKAWNKPCEPC----PTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICA 1820
            + N       PCE       +P    +  +C   PG+     T   +DIDEC   P  C 
Sbjct: 838  SPN-------PCENAAVCKESPNFESYTCLCA--PGWQGQRCT---IDIDECISKP--CM 883

Query: 1821 N-GVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECA 1879
            N G+C N  GS+ CECP GFS  D     EDID+C    N CQ    C++   ++ C C 
Sbjct: 884  NHGLCHNTQGSYMCECPPGFSGMDCE---EDIDDCL--ANPCQNGGSCMDGVNTFSCLCL 938

Query: 1880 AGFKLSPNGACVDRNECLEIPNVCSH-GLCVDLQGSYQCICHNGFKASQDQTMC-MDVDE 1937
             GF  + +    D NECL  P  C + G C D   SY C C  GF    D   C  +++E
Sbjct: 939  PGF--TGDKCQTDMNECLSEP--CKNGGTCSDYVNSYTCKCQAGF----DGVHCENNINE 990

Query: 1938 CERHPCGN-GTCKNTVGSYNCLCYPGFELTHNNDCL-DIDECSSFFGQVCRN-GRCFNEI 1994
            C    C N GTC + + S++CLC  GF     + CL +I+ECSS     C N G C + +
Sbjct: 991  CTESSCFNGGTCVDGINSFSCLCPVGFT---GSFCLHEINECSS---HPCLNEGTCVDGL 1044

Query: 1995 GSFKCLCNEGYELTPDGKNCID-TNECVALPGSCSPGTCQNLEGSFRCICPPGY-----E 2048
            G+++C C  GY     GKNC    N C   P   + GTC   +   +C+CP G+     +
Sbjct: 1045 GTYRCSCPLGY----TGKNCQTLVNLCSRSPCK-NKGTCVQKKAESQCLCPSGWAGAYCD 1099

Query: 2049 VKSENCIDINECDED---PNICLF-GSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFC 2104
            V + +C DI          ++C   G C N      C CP G+              S+C
Sbjct: 1100 VPNVSC-DIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYT------------GSYC 1146

Query: 2105 FTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPS 2164
                +  +C    A N  +    CS   G   G  CE  P    V     C Y       
Sbjct: 1147 EEQLD--EC----ASNPCQHGATCSDFIG---GYRCECVPGYQGVN----CEY------- 1186

Query: 2165 LHDTREDVNECLESPGICSN-GQCINTDGSFRCECPMGYNLDYTGVRCVDT-DECSIGNP 2222
                  +V+EC   P  C N G CI+    F+C CP G      G+ C +  D+C+ G  
Sbjct: 1187 ------EVDECQNQP--CQNGGTCIDLVNHFKCSCPPGTR----GLLCEENIDDCARGPH 1234

Query: 2223 CGN-GTCTNVIGSFECNCNEGFEPGPMMNCE-DINECAQNPLLC--AFRCMNTFGSYECT 2278
            C N G C + IG + C C  GF       CE DINEC  NP     +  C+     Y C 
Sbjct: 1235 CLNGGQCMDRIGGYSCRCLPGFAG---ERCEGDINECLSNPCSSEGSLDCIQLTNDYLCV 1291

Query: 2279 CPIGYALREDQKMCKDLDECAEGLHDCESRG--MMCKNLIGTFMCICPPGMARRPDGEGC 2336
            C   +  R  +     +D C +    C + G   +  N+   F+C CPPG +        
Sbjct: 1292 CRSAFTGRHCETF---VDVCPQ--MPCLNGGTCAVASNMPDGFICRCPPGFS-------- 1338

Query: 2337 VDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQ 2396
                            RC +  G  +C   E    ++SG  C       C +    + CQ
Sbjct: 1339 --------------GARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQ 1384

Query: 2397 MASSSRNLVTKSECCCDGGRGW-GHQCELCPL-PGTAQYKKICPHGPGYTTDGRDIDECK 2454
               S           C     + G +CEL    P T     +  +      DG   + C 
Sbjct: 1385 HGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACN 1444

Query: 2455 VMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQ 2514
                    G C  TM +    C        S   C D          C+ +C   E  + 
Sbjct: 1445 SHACQWDGGDCSLTMENPWANCS-------SPLPCWDYIN-----NQCDELCNTVECLFD 1492

Query: 2515 CSCPRGYVLQEDGKTCKDLDEC--QTKQHNCQFLC 2547
                  +  Q + KTCK    C    K ++C   C
Sbjct: 1493 -----NFECQGNSKTCKYDKYCADHFKDNHCDQGC 1522



 Score =  443 bits (1139), Expect = e-123
 Identities = 468/1651 (28%), Positives = 657/1651 (39%), Gaps = 424/1651 (25%)

Query: 543  PCTN-GDCVNTP-GSYYCKCHAGF------QRTP-TKQACIDIDECIQNGVL------CK 587
            PC N G CV    G+ YCKC  GF       R P  K  C +   C+   +L      C 
Sbjct: 34   PCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCA 93

Query: 588  NG------------------RCVN-------TDGSFQCICNAGFELTTDGKNCVDHDECT 622
            +G                   C+N       +  +++C C  GF     GK C   D C 
Sbjct: 94   SGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGF----TGKECQWTDAC- 148

Query: 623  TTNMCLNG-MCINEDGSFKCICKPGFVLAPNGRYC-TDVDECQTPGICMN-GHCINSEGS 679
             ++ C NG  C      F C C  GF     G+ C TDV+EC  PG C + G C+N  GS
Sbjct: 149  LSHPCANGSTCTTVANQFSCKCLTGF----TGQKCETDVNECDIPGHCQHGGTCLNLPGS 204

Query: 680  FRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGF-G 738
            ++C CP G      G+ C   ++       +  G C +   G  T  EC C     GF G
Sbjct: 205  YQCQCPQGFT----GQYCDSLYVPCAPSPCVNGGTCRQ--TGDFT-FECNCLP---GFEG 254

Query: 739  EPCQ----PCPAKNSAEFHGLCSSGVGITVDGR------------DINECALDPDICAN- 781
              C+     CP  +  +  G+C  GV  T + R            D++EC L P+ C N 
Sbjct: 255  STCERNIDDCP-NHRCQNGGVCVDGVN-TYNCRCPPQWTGQFCTEDVDECLLQPNACQNG 312

Query: 782  GICENLRGSYRCNCNSGYEPD--------------ASGRNCID----------------- 810
            G C N  G Y C C +G+  D                G  CID                 
Sbjct: 313  GTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLL 372

Query: 811  --IDECLVNRLLCDNGLCRNTP--GSYSCTCPPGYVFRTETETCEDINEC---ESNPCVN 863
              +D+  ++       LC   P  G Y CTCP GY      +  ED++EC    SNPC +
Sbjct: 373  CHLDDACISNPCHKGALCDTNPLNGQYICTCPQGY---KGADCTEDVDECAMANSNPCEH 429

Query: 864  -GACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCA 922
             G C N  G+F+CEC                LKG         RCE++IN      EC +
Sbjct: 430  AGKCVNTDGAFHCEC----------------LKG-----YAGPRCEMDIN------ECHS 462

Query: 923  TLGAAWGSPCERCELDTACPRGLA--------RIKGVTCE-DVNECEVFPGVCPNGRCVN 973
                      + C+ D  C   +           KGV CE ++NEC+  P V  NG+CV+
Sbjct: 463  ----------DPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCV-NNGQCVD 511

Query: 974  SKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAW 1033
                F C CP G     TG VC  I ++ C        C++                   
Sbjct: 512  KVNRFQCLCPPGF----TGPVC-QIDIDDC----SSTPCLN------------------- 543

Query: 1034 GTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTI 1093
            G +C + P      YE  C  G          TG    ++I+ C   P  C +G+C++ I
Sbjct: 544  GAKCIDHP----NGYECQCATG---------FTGVLCEENIDNCD--PDPCHHGQCQDGI 588

Query: 1094 GSFKCRCNSGFALDMEERNCTD-IDECRISPDLCGSGICVNTPGSFECECFEGYESGFMM 1152
             S+ C CN G+   +    C+D IDEC  SP L   G C++    ++C C  G  SG   
Sbjct: 589  DSYTCICNPGYMGAI----CSDQIDECYSSPCL-NDGRCIDLVNGYQCNCQPG-TSGV-- 640

Query: 1153 MKNC-MDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDC-VDINECSLSDNL 1210
              NC ++ D+C  NP  C  G C++    + C C  G     + + C +DI+EC  + N 
Sbjct: 641  --NCEINFDDCASNP--CIHGICMDGINRYSCVCSPGF----TGQRCNIDIDEC--ASNP 690

Query: 1211 CRNG-KCVNMIGTYQCSCNPGYQATPDRQGC-TDIDECMIMNGGCDTQCTNSEGSYECSC 1268
            CR G  C+N +  ++C C  G    P    C + ++EC + N      CT     Y+C C
Sbjct: 691  CRKGATCINGVNGFRCICPEG----PHHPSCYSQVNEC-LSNPCIHGNCTGGLSGYKCLC 745

Query: 1269 SEGYALMPDGRSC-ADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVN 1327
              G+     G +C  D +EC +NP   +GG C N+   YRC C  GF         ++++
Sbjct: 746  DAGWV----GINCEVDKNECLSNP-CQNGGTCDNLVNGYRCTCKKGFKG---YNCQVNID 797

Query: 1328 ECDLNSNICM-FGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLN 1386
            EC   SN C+  G C +    + CHC L Y+ K     C  V       + C+  A C  
Sbjct: 798  EC--ASNPCLNQGTCFDDISGYTCHCVLPYTGK----NCQTV-LAPCSPNPCENAAVCKE 850

Query: 1387 IPG--SFKCSCREGWIGNGIKC-IDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGD 1443
             P   S+ C C  GW   G +C ID+DEC   +  C  +  C NT GSY C C  GF+  
Sbjct: 851  SPNFESYTCLCAPGW--QGQRCTIDIDECI--SKPCMNHGLCHNTQGSYMCECPPGFS-- 904

Query: 1444 GFTC-SDVDECAENINLCEN-GQCLNVPGAYRCECEMGFTPASDSRSCQ-DIDECSFQNI 1500
            G  C  D+D+C    N C+N G C++    + C C  GFT       CQ D++EC  +  
Sbjct: 905  GMDCEEDIDDCL--ANPCQNGGSCMDGVNTFSCLCLPGFT----GDKCQTDMNECLSEPC 958

Query: 1501 CVFGTCNNLPGMFHCICDDGYELDRTGGNC-TDIDECADPINCVN-GLCVNTPGRYECNC 1558
               GTC++    + C C  G++    G +C  +I+EC +  +C N G CV+    + C C
Sbjct: 959  KNGGTCSDYVNSYTCKCQAGFD----GVHCENNINECTES-SCFNGGTCVDGINSFSCLC 1013

Query: 1559 PPDFQLNPTGVGCVDNRVGNC----YLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAW 1614
            P  F    TG  C+ + +  C     L  G   DG  +      +G +  +C   +    
Sbjct: 1014 PVGF----TGSFCL-HEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCS 1068

Query: 1615 GNPCE---TCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQE---LPGLCQ-GGNCI 1667
             +PC+   TC      E   LCP G       +  +  DI   +    +  LCQ  G CI
Sbjct: 1069 RSPCKNKGTCVQ-KKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCI 1127

Query: 1668 NTFGSFQCECPQGYYLSEDTRICED-IDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQV 1726
            N   +  C+CP GY  S     CE+ +DEC ++P   G  TC + +G Y C C P Y  V
Sbjct: 1128 NAGNTHYCQCPLGYTGS----YCEEQLDECASNPCQHG-ATCSDFIGGYRCECVPGYQGV 1182

Query: 1727 NGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTAD 1786
            N  +   + +   C    NG TC      ++     C               CP PGT  
Sbjct: 1183 NCEYEVDECQNQPC---QNGGTC-----IDLVNHFKC--------------SCP-PGTRG 1219

Query: 1787 FKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLL 1846
               +C                +ID+C   P     G C+++IG + C C  GF+      
Sbjct: 1220 L--LCEE--------------NIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGER--- 1260

Query: 1847 VCE-DIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSH 1905
             CE DI+EC +     + + DCI     Y C C + F             C    +VC  
Sbjct: 1261 -CEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAF---------TGRHCETFVDVCP- 1309

Query: 1906 GLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTC---KNTVGSYNCLCYPG 1962
                      Q  C NG                       GTC    N    + C C PG
Sbjct: 1310 ----------QMPCLNG-----------------------GTCAVASNMPDGFICRCPPG 1336

Query: 1963 FELTHNNDCLDIDECSSFFGQV-CRNG-RCFNEIGSFKCLCNEGYELTPDGKNCIDTNEC 2020
            F             C S  GQV CR G +C +     +C C       P  ++C   + C
Sbjct: 1337 FSGA---------RCQSSCGQVKCRKGEQCVHTASGPRCFC-------PSPRDC--ESGC 1378

Query: 2021 VALP----GSCSPGTCQNLEGSFRCICPPGY 2047
             + P    GSC P   Q     + C C P +
Sbjct: 1379 ASSPCQHGGSCHP---QRQPPYYSCQCAPPF 1406



 Score =  400 bits (1028), Expect = e-110
 Identities = 406/1452 (27%), Positives = 585/1452 (40%), Gaps = 305/1452 (21%)

Query: 505  CLNGRCIPTVS--SYRCECNMGYKQDANGDCIDVDECTSNPCTNGD-CVNTPGSYYCKCH 561
            CLNG     +S  +Y C C +G+      +C   D C S+PC NG  C      + CKC 
Sbjct: 115  CLNGGTCHMLSRDTYECTCQVGF---TGKECQWTDACLSHPCANGSTCTTVANQFSCKCL 171

Query: 562  AGFQRTPTKQAC-IDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDE 620
             GF    T Q C  D++EC   G     G C+N  GS+QC C  GF     G+ C     
Sbjct: 172  TGF----TGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF----TGQYCDSLYV 223

Query: 621  CTTTNMCLNGMCINEDG--SFKCICKPGFVLA---------PN----------------- 652
                + C+NG    + G  +F+C C PGF  +         PN                 
Sbjct: 224  PCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYN 283

Query: 653  --------GRYCT-DVDEC-QTPGICMN-GHCINSEGSFRCDCPPG-----LAVGMDGRV 696
                    G++CT DVDEC   P  C N G C N  G + C C  G      +  +D   
Sbjct: 284  CRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCA 343

Query: 697  CVDTHMRSTCYGGIKKGVCVRPFPGA---VTKSECCCANPDYGFGEPCQPCPAKNSAEFH 753
                   STC   +    C+ P   A       + C +NP +  G  C   P   + ++ 
Sbjct: 344  FASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHK-GALCDTNPL--NGQYI 400

Query: 754  GLCSSGVGITVDGRDINECAL-DPDICAN-GICENLRGSYRCNCNSGYEPDASGRNC-ID 810
              C  G        D++ECA+ + + C + G C N  G++ C C  GY    +G  C +D
Sbjct: 401  CTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGY----AGPRCEMD 456

Query: 811  IDECLVNRLLCDN-GLCRNTPGSYSCTCPPGYVFRTETETCE-DINECESNPCV-NGACR 867
            I+EC  +   C N   C +  G ++C C PG+    +   CE +INEC+SNPCV NG C 
Sbjct: 457  INECHSDP--CQNDATCLDKIGGFTCLCMPGF----KGVHCELEINECQSNPCVNNGQCV 510

Query: 868  NNLGSFNCECSPGSKLSSTGLIC---IDSLKGTCWLNIQDSRCEVNINGATLKSEC-CAT 923
            + +  F C C PG     TG +C   ID    T  LN   ++C  + NG     EC CAT
Sbjct: 511  DKVNRFQCLCPPG----FTGPVCQIDIDDCSSTPCLN--GAKCIDHPNG----YECQCAT 560

Query: 924  --LGAAWGSPCERCELDTA----CPRGL--------ARIKGVTCED-VNECEVFPGVCPN 968
               G       + C+ D      C  G+            G  C D ++EC   P  C N
Sbjct: 561  GFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSP--CLN 618

Query: 969  -GRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPV-PGKFRMDACC 1026
             GRC++    + C C       GT  V  +I  + C      + CIH +        +C 
Sbjct: 619  DGRCIDLVNGYQCNCQ-----PGTSGVNCEINFDDC----ASNPCIHGICMDGINRYSCV 669

Query: 1027 CAVGAAWGTEC----EECPK----------PGTKEYETLCPRGAGFANRGDVLTGRPFYK 1072
            C+ G   G  C    +EC             G   +  +CP G    +          Y 
Sbjct: 670  CSPGFT-GQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPS---------CYS 719

Query: 1073 DINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNC-TDIDECRISPDLCGSGIC 1131
             +NEC + P  C +G C   +  +KC C++G+       NC  D +EC  +P   G G C
Sbjct: 720  QVNECLSNP--CIHGNCTGGLSGYKCLCDAGWV----GINCEVDKNECLSNPCQNG-GTC 772

Query: 1132 VNTPGSFECECFEGYESGFMMMKNC-MDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1190
             N    + C C +G++       NC ++IDEC  NP L   GTC +    + C C L + 
Sbjct: 773  DNLVNGYRCTCKKGFKG-----YNCQVNIDECASNPCL-NQGTCFDDISGYTCHCVLPY- 825

Query: 1191 LSPSREDCVDINECSLSDNLCRNG---KCVNMIGTYQCSCNPGYQATPDRQGCT-DIDEC 1246
               + ++C  +     S N C N    K      +Y C C PG+Q     Q CT DIDEC
Sbjct: 826  ---TGKNCQTV-LAPCSPNPCENAAVCKESPNFESYTCLCAPGWQG----QRCTIDIDEC 877

Query: 1247 M---IMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC-ADIDECENNPDICDGGQCTNI 1302
            +    MN G    C N++GSY C C  G++    G  C  DID+C  NP   +GG C + 
Sbjct: 878  ISKPCMNHGL---CHNTQGSYMCECPPGFS----GMDCEEDIDDCLANP-CQNGGSCMDG 929

Query: 1303 PGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGT 1362
               + CLC  GF      K   D+NEC L+      G C +   S+ C CQ G+    G 
Sbjct: 930  VNTFSCLCLPGFTGD---KCQTDMNEC-LSEPCKNGGTCSDYVNSYTCKCQAGFD---GV 982

Query: 1363 TGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCI-DLDECSNGTHQCSI 1421
                +++EC     +C    +C++   SF C C  G+ G+   C+ +++ECS  +H C  
Sbjct: 983  HCENNINECT--ESSCFNGGTCVDGINSFSCLCPVGFTGS--FCLHEINECS--SHPCLN 1036

Query: 1422 NAQCVNTPGSYRCACSEGFTGDG----------FTCSDVDEC----AENINLC------- 1460
               CV+  G+YRC+C  G+TG              C +   C    AE+  LC       
Sbjct: 1037 EGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGA 1096

Query: 1461 -------------------------ENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDEC 1495
                                      +G C+N    + C+C +G+T    S   + +DEC
Sbjct: 1097 YCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYT---GSYCEEQLDEC 1153

Query: 1496 SFQNICVFG-TCNNLPGMFHCICDDGYELDRTGGNCT-DIDECADPINCVNGLCVNTPGR 1553
            +  N C  G TC++  G + C C  GY+    G NC  ++DEC +      G C++    
Sbjct: 1154 A-SNPCQHGATCSDFIGGYRCECVPGYQ----GVNCEYEVDECQNQPCQNGGTCIDLVNH 1208

Query: 1554 YECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIG-------VGVSRSSC 1606
            ++C+CPP       G+ C +N + +C    GP       C   IG        G +   C
Sbjct: 1209 FKCSCPP----GTRGLLCEEN-IDDC--ARGPHCLNGGQCMDRIGGYSCRCLPGFAGERC 1261

Query: 1607 CCSLGKAWGNPCE---TCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQG 1663
               + +   NPC    +   +  T  Y LC     F           +D C ++P L  G
Sbjct: 1262 EGDINECLSNPCSSEGSLDCIQLTNDY-LCVCRSAFTGRHCETF---VDVCPQMPCL-NG 1316

Query: 1664 GNCI---NTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPG-TCYNTLGNYTCIC 1719
            G C    N    F C CP G+  +     C  +         C  G  C +T     C C
Sbjct: 1317 GTCAVASNMPDGFICRCPPGFSGARCQSSCGQVK--------CRKGEQCVHTASGPRCFC 1368

Query: 1720 PPEYMQVNG--------GHNCMDMRK-----SFCYRSYNGTTCE-NELPFNVTKRMCCCT 1765
            P      +G        G +C   R+       C   ++G+ CE    P +     C   
Sbjct: 1369 PSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQ 1428

Query: 1766 YNVGKAWNKPCE 1777
            Y   KA +  C+
Sbjct: 1429 YCADKARDGVCD 1440



 Score =  393 bits (1010), Expect = e-108
 Identities = 382/1369 (27%), Positives = 546/1369 (39%), Gaps = 309/1369 (22%)

Query: 1465 CLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELD 1524
            C   P A+  +C  G+ P            C  + +CV  T +N  G  +C C +G+   
Sbjct: 18   CCAAP-AHALQCRDGYEP------------CVNEGMCV--TYHN--GTGYCKCPEGF--- 57

Query: 1525 RTGGNCTDIDECADPINCVNG-LCVNTP--GRYECNCPPDFQLNPTGVGCVDNRVGNCYL 1581
              G  C   D C +   C NG  CV     G+  C C   F    TG  C  +    C++
Sbjct: 58   -LGEYCQHRDPC-EKNRCQNGGTCVAQAMLGKATCRCASGF----TGEDCQYSTSHPCFV 111

Query: 1582 KFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRP 1641
                                  S  C + G        TC  ++   Y   C  G   + 
Sbjct: 112  ----------------------SRPCLNGG--------TCHMLSRDTYECTCQVGFTGKE 141

Query: 1642 NPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICE-DIDECFAHP 1700
               T      D C   P    G  C      F C+C  G+   +    CE D++EC   P
Sbjct: 142  CQWT------DACLSHP-CANGSTCTTVANQFSCKCLTGFTGQK----CETDVNECDI-P 189

Query: 1701 GVCGPG-TCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTK 1759
            G C  G TC N  G+Y C CP                     + + G  C++        
Sbjct: 190  GHCQHGGTCLNLPGSYQCQCP---------------------QGFTGQYCDSLYV----- 223

Query: 1760 RMCCCTYNVGKAWNKPCEPCPTPG------TADFKTICGNIPGFTFDIHTGKAVD--IDE 1811
                           PC P P         T DF   C  +PGF      G   +  ID+
Sbjct: 224  ---------------PCAPSPCVNGGTCRQTGDFTFECNCLPGFE-----GSTCERNIDD 263

Query: 1812 CKEIPGICANG-VCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINS 1870
            C      C NG VC++ + ++ C CP  ++        ED+DEC    N CQ    C N 
Sbjct: 264  CPNHR--CQNGGVCVDGVNTYNCRCPPQWTGQ---FCTEDVDECLLQPNACQNGGTCANR 318

Query: 1871 PGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQT 1930
             G Y C C  G+       C +  +     +      C+D   S+ C+C  G KA     
Sbjct: 319  NGGYGCVCVNGWS---GDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEG-KAG---L 371

Query: 1931 MCMDVDECERHPCGNGTCKNTV---GSYNCLCYPGFELTHNNDCL-DIDECSSFFGQVCR 1986
            +C   D C  +PC  G   +T    G Y C C  G++     DC  D+DEC+      C 
Sbjct: 372  LCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYK---GADCTEDVDECAMANSNPCE 428

Query: 1987 N-GRCFNEIGSFKCLCNEGYELTPDGKNC-IDTNECVALPGSCSPGTCQNLEGSFRCICP 2044
            + G+C N  G+F C C +GY     G  C +D NEC + P   +  TC +  G F C+C 
Sbjct: 429  HAGKCVNTDGAFHCECLKGYA----GPRCEMDINECHSDPCQ-NDATCLDKIGGFTCLCM 483

Query: 2045 PGYEVKSENC-IDINECDEDPNICLFGSCTNTPGGFQCLCPPGFV-------LSD----- 2091
            PG+  K  +C ++INEC  +P +   G C +    FQCLCPPGF        + D     
Sbjct: 484  PGF--KGVHCELEINECQSNPCVNN-GQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTP 540

Query: 2092 --NGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEV 2149
              NG +C D    +        +C     F        C +       DPC      D +
Sbjct: 541  CLNGAKCIDHPNGY--------ECQCATGFTGV----LCEENIDNCDPDPCHHGQCQDGI 588

Query: 2150 -AFQDLCPYGH-GTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYT 2207
             ++  +C  G+ G + S     + ++EC  SP + ++G+CI+    ++C C  G +    
Sbjct: 589  DSYTCICNPGYMGAICS-----DQIDECYSSPCL-NDGRCIDLVNGYQCNCQPGTS---- 638

Query: 2208 GVRC-VDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAF 2266
            GV C ++ D+C+  NPC +G C + I  + C C+ GF  G   N  DI+ECA NP     
Sbjct: 639  GVNCEINFDDCA-SNPCIHGICMDGINRYSCVCSPGFT-GQRCNI-DIDECASNPCRKGA 695

Query: 2267 RCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMM---CKNLIGTFMCIC 2323
             C+N    + C CP G               C   +++C S   +   C   +  + C+C
Sbjct: 696  TCINGVNGFRCICPEG----------PHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLC 745

Query: 2324 PPGMARRPDGEGC-VDENECRTKPGICENG-RCVNIIGSYRCECNEGFQSSSSGT---EC 2378
              G      G  C VD+NEC + P  C+NG  C N++  YRC C +GF+  +      EC
Sbjct: 746  DAGWV----GINCEVDKNECLSNP--CQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDEC 799

Query: 2379 LDN---RQGLCFAEVLQTICQ--MASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQY 2433
              N    QG CF ++    C   +  + +N  T    C          C+    P    Y
Sbjct: 800  ASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCK--ESPNFESY 857

Query: 2434 KKICPHGPGYTTDGRDIDECKVMPNLCTN-GQCINTMGSFRCFCKVGYTTDISGTSCI-D 2491
              +C  G        DIDEC   P  C N G C NT GS+ C C  G+    SG  C  D
Sbjct: 858  TCLCAPGWQGQRCTIDIDECISKP--CMNHGLCHNTQGSYMCECPPGF----SGMDCEED 911

Query: 2492 LDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCK-DLDECQTKQHNCQFLCVNT 2550
            +D+C  +P      C +   ++ C C  G+     G  C+ D++EC ++       C + 
Sbjct: 912  IDDCLANPCQNGGSCMDGVNTFSCLCLPGFT----GDKCQTDMNECLSEPCKNGGTCSDY 967

Query: 2551 LGGFTCKCPPGFTQHHTACIDN-NECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATG 2609
            +  +TCKC  GF   H  C +N NEC    S C   G C +   SFSC C  GF    TG
Sbjct: 968  VNSYTCKCQAGFDGVH--CENNINECTE--SSCFNGGTCVDGINSFSCLCPVGF----TG 1019

Query: 2610 LNC-EDVDECDGNHRCQHG-CQNILGGYRCGCPQGY-----------------------I 2644
              C  +++EC  +     G C + LG YRC CP GY                       +
Sbjct: 1020 SFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCV 1079

Query: 2645 QHYQWNQCVDENE-----CSNPN-ACGSAS----------------CYNTLGSYKCACPS 2682
            Q    +QC+  +      C  PN +C  A+                C N   ++ C CP 
Sbjct: 1080 QKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPL 1139

Query: 2683 GFSFDQFSSACHD-VNECSSSKNPCNYG--CSNTEGGYLCGCPPGYYRV 2728
            G++     S C + ++EC+S  NPC +G  CS+  GGY C C PGY  V
Sbjct: 1140 GYT----GSYCEEQLDECAS--NPCQHGATCSDFIGGYRCECVPGYQGV 1182



 Score =  347 bits (891), Expect = 8e-95
 Identities = 366/1332 (27%), Positives = 522/1332 (39%), Gaps = 289/1332 (21%)

Query: 104  LPGGNQC--------------IVPICRNSCGDGFCSRPN-----MCTCSSGQISSTCGSK 144
            LPG  QC               VP   + C +G   R        C C  G   STC  +
Sbjct: 201  LPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTC-ER 259

Query: 145  SIQQC-SVRCMNGGTCADD----HCQCQKGYIGTYCGQPVCE-----NGCQNGGRCIGPN 194
            +I  C + RC NGG C D     +C+C   + G +C + V E     N CQNGG C   N
Sbjct: 260  NIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRN 319

Query: 195  R---CACVYGFTGPQCERDYRT---------GPCFTQVNNQ--MCQGQLTGIVCTKTLCC 240
                C CV G++G  C  +              C  +V +   MC     G++C     C
Sbjct: 320  GGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDAC 379

Query: 241  ATIGRAWGHPCEMCPAQPQ---PCRRGFIPNIRTGAC-QDVDEC-QAIPGICQ-GGNCIN 294
             +     G  C+  P   Q    C +G+    +   C +DVDEC  A    C+  G C+N
Sbjct: 380  ISNPCHKGALCDTNPLNGQYICTCPQGY----KGADCTEDVDECAMANSNPCEHAGKCVN 435

Query: 295  TVGSFECRCPAGHKQSETTQKCE-DIDECSIIPGICET-GECSNTVGSYFCVCPRGYVTS 352
            T G+F C C  G+       +CE DI+EC   P  C+    C + +G + C+C  G+   
Sbjct: 436  TDGAFHCECLKGY----AGPRCEMDINECHSDP--CQNDATCLDKIGGFTCLCMPGF--- 486

Query: 353  TDGSRCIDQRTGMCFSG--LVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGS 410
              G  C +     C S   + NG+C      ++ + QC C P      G     C +   
Sbjct: 487  -KGVHC-ELEINECQSNPCVNNGQCVD----KVNRFQCLCPP------GFTGPVCQIDID 534

Query: 411  EEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGF--- 467
            +     C++G      P     +   TG  G     N +   P          G      
Sbjct: 535  DCSSTPCLNGAKCIDHPNGYECQCA-TGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTC 593

Query: 468  --SPGVGGA---------------------GVGAGGQGPIITGLTILNQTIDICKHHANL 504
              +PG  GA                      +  G Q     G + +N  I+     +N 
Sbjct: 594  ICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNP 653

Query: 505  CLNGRCIPTVSSYRCECNMGYK-QDANGDCIDVDECTSNPCTNG-DCVNTPGSYYCKCHA 562
            C++G C+  ++ Y C C+ G+  Q  N   ID+DEC SNPC  G  C+N    + C C  
Sbjct: 654  CIHGICMDGINRYSCVCSPGFTGQRCN---IDIDECASNPCRKGATCINGVNGFRCICPE 710

Query: 563  GFQRTPTKQACI-DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNC-VDHDE 620
            G    P   +C   ++EC+ N   C +G C      ++C+C+AG+     G NC VD +E
Sbjct: 711  G----PHHPSCYSQVNECLSNP--CIHGNCTGGLSGYKCLCDAGWV----GINCEVDKNE 760

Query: 621  CTTTNMCLN-GMCINEDGSFKCICKPGFVLAPNGRYC-TDVDECQTPGICMNGHCINSEG 678
            C  +N C N G C N    ++C CK GF     G  C  ++DEC +      G C +   
Sbjct: 761  C-LSNPCQNGGTCDNLVNGYRCTCKKGF----KGYNCQVNIDECASNPCLNQGTCFDDIS 815

Query: 679  SFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFG 738
             + C                                CV P+ G   ++            
Sbjct: 816  GYTCH-------------------------------CVLPYTGKNCQTVLA--------- 835

Query: 739  EPCQPCPAKNSA---------EFHGLCSSGVGITVDGRDINECALDPDICAN-GICENLR 788
             PC P P +N+A          +  LC+ G        DI+EC   P  C N G+C N +
Sbjct: 836  -PCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKP--CMNHGLCHNTQ 892

Query: 789  GSYRCNCNSGYEPDASGRNC-IDIDECLVNRLLCDN-GLCRNTPGSYSCTCPPGYVFRTE 846
            GSY C C  G+    SG +C  DID+CL N   C N G C +   ++SC C PG+   T 
Sbjct: 893  GSYMCECPPGF----SGMDCEEDIDDCLANP--CQNGGSCMDGVNTFSCLCLPGF---TG 943

Query: 847  TETCEDINECESNPCVN-GACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDS 905
             +   D+NEC S PC N G C + + S+ C+C  G                         
Sbjct: 944  DKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAG---------------------FDGV 982

Query: 906  RCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTC-EDVNECEVFPG 964
             CE NIN  T +S C        G     C     CP G     G  C  ++NEC   P 
Sbjct: 983  HCENNINECT-ESSCFNGGTCVDGINSFSC----LCPVGFT---GSFCLHEINECSSHP- 1033

Query: 965  VCPN-GRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLK--WDEDECIHPVPGKFR 1021
             C N G CV+  G++ C CP G     TG+ C  + +  C      ++  C+     K  
Sbjct: 1034 -CLNEGTCVDGLGTYRCSCPLGY----TGKNCQTL-VNLCSRSPCKNKGTCVQ----KKA 1083

Query: 1022 MDACCCAVGAAWGTECE----ECPKPGTKE---YETLCPRGAGFANRGDV--------LT 1066
               C C  G A G  C+     C    ++     E LC       N G+          T
Sbjct: 1084 ESQCLCPSGWA-GAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYT 1142

Query: 1067 GRPFYKDINECKAFPGMCTYG-KCRNTIGSFKCRCNSGFALDMEERNCT-DIDECRISPD 1124
            G    + ++EC + P  C +G  C + IG ++C C  G+    +  NC  ++DEC+  P 
Sbjct: 1143 GSYCEEQLDECASNP--CQHGATCSDFIGGYRCECVPGY----QGVNCEYEVDECQNQPC 1196

Query: 1125 LCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCD 1184
              G G C++    F+C C  G   G +  +N   ID+C R P    GG C++  G + C 
Sbjct: 1197 QNG-GTCIDLVNHFKCSCPPG-TRGLLCEEN---IDDCARGPHCLNGGQCMDRIGGYSCR 1251

Query: 1185 CPLGHELSPSREDCV-DINECSLSDNLCRNGK--CVNMIGTYQCSCNPGYQATPDRQGCT 1241
            C  G     + E C  DINEC LS+     G   C+ +   Y C C   +     R   T
Sbjct: 1252 CLPGF----AGERCEGDINEC-LSNPCSSEGSLDCIQLTNDYLCVCRSAFTG---RHCET 1303

Query: 1242 DIDECMIM---NGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQ 1298
             +D C  M   NGG     +N    + C C  G++      SC  + +C        G Q
Sbjct: 1304 FVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQV-KCRK------GEQ 1356

Query: 1299 CTNIPGEYRCLC 1310
            C +     RC C
Sbjct: 1357 CVHTASGPRCFC 1368



 Score =  338 bits (868), Expect = 4e-92
 Identities = 377/1415 (26%), Positives = 552/1415 (39%), Gaps = 300/1415 (21%)

Query: 79   QQDVLRGPNVCGSRFHSY---CCPGWK--------------TLPGGNQCIVPICRNSCGD 121
            Q +  +    C +R   Y   C  GW               +   G+ CI  +   SC  
Sbjct: 305  QPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMC 364

Query: 122  GFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCE 181
                   +C      IS+ C   ++  C    +NG       C C +GY G  C + V E
Sbjct: 365  PEGKAGLLCHLDDACISNPCHKGAL--CDTNPLNGQYI----CTCPQGYKGADCTEDVDE 418

Query: 182  ------NGCQNGGRCI---GPNRCACVYGFTGPQCERDY---RTGPCFTQVNNQMCQGQL 229
                  N C++ G+C+   G   C C+ G+ GP+CE D     + PC    N+  C  ++
Sbjct: 419  CAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPC---QNDATCLDKI 475

Query: 230  TGIVC------TKTLCCATIGRAWGHPC---EMCPAQPQPCRRGFIPNIRTGACQ-DVDE 279
             G  C          C   I     +PC     C  +    +    P      CQ D+D+
Sbjct: 476  GGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDD 535

Query: 280  CQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCED-IDECSIIPGICETGECSNTV 338
            C + P +  G  CI+    +EC+C  G     T   CE+ ID C   P  C  G+C + +
Sbjct: 536  CSSTPCL-NGAKCIDHPNGYECQCATGF----TGVLCEENIDNCD--PDPCHHGQCQDGI 588

Query: 339  GSYFCVCPRGYVTSTDGSRCIDQRTGMCFSG--LVNGRCAQELPGRMTKMQCCCEPGRCW 396
             SY C+C  GY+    G+ C DQ    C+S   L +GRC   + G     QC C+P    
Sbjct: 589  DSYTCICNPGYM----GAICSDQ-IDECYSSPCLNDGRCIDLVNG----YQCNCQP---- 635

Query: 397  GIGTIPEACPVRGSEEYRRLCMDGLPMGGIPG-SAGSRPGGTGGNGFAPSGNGNGYGPGG 455
              GT    C +   +     C+ G+ M GI   S    PG TG        +     P  
Sbjct: 636  --GTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDI-DECASNPCR 692

Query: 456  TGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVS 515
             G   I G NGF           G   P  +  + +N+ +      +N C++G C   +S
Sbjct: 693  KGATCINGVNGFR-----CICPEGPHHP--SCYSQVNECL------SNPCIHGNCTGGLS 739

Query: 516  SYRCECNMGYKQDANGDC-IDVDECTSNPCTN-GDCVNTPGSYYCKCHAGFQRTPTKQAC 573
             Y+C C+ G+      +C +D +EC SNPC N G C N    Y C C  GF+    +   
Sbjct: 740  GYKCLCDAGW---VGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQ--- 793

Query: 574  IDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCI 633
            ++IDEC  N  L   G C +    + C C     L   GKNC       + N C N    
Sbjct: 794  VNIDECASNPCL-NQGTCFDDISGYTCHC----VLPYTGKNCQTVLAPCSPNPCENAAVC 848

Query: 634  NEDGSFK---CICKPGFVLAPNGRYCT-DVDECQTPGICMNGHCINSEGSFRCDCPPGLA 689
             E  +F+   C+C PG+     G+ CT D+DEC +     +G C N++GS+ C+CPPG +
Sbjct: 849  KESPNFESYTCLCAPGW----QGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFS 904

Query: 690  VGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGF-GEPCQPCPAKN 748
             GMD    +D  + + C  G   G C+      V    C C     GF G+ CQ      
Sbjct: 905  -GMDCEEDIDDCLANPCQNG---GSCM----DGVNTFSCLCLP---GFTGDKCQ------ 947

Query: 749  SAEFHGLCSSGVGITVDGRDINECALDPDICAN-GICENLRGSYRCNCNSGYEPDASGRN 807
                               D+NEC  +P  C N G C +   SY C C +G++    G +
Sbjct: 948  ------------------TDMNECLSEP--CKNGGTCSDYVNSYTCKCQAGFD----GVH 983

Query: 808  C-IDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVN-GA 865
            C  +I+EC  +    + G C +   S+SC CP G+   T +    +INEC S+PC+N G 
Sbjct: 984  CENNINECTESSCF-NGGTCVDGINSFSCLCPVGF---TGSFCLHEINECSSHPCLNEGT 1039

Query: 866  CRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLG 925
            C + LG++ C C     L  TG  C  +L   C      S C+        K+E      
Sbjct: 1040 CVDGLGTYRCSC----PLGYTGKNC-QTLVNLC----SRSPCKNKGTCVQKKAESQCLCP 1090

Query: 926  AAW-GSPCE--RCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCEC 982
            + W G+ C+      D A  R     +GV  E +  C+       +G C+N+  + +C+C
Sbjct: 1091 SGWAGAYCDVPNVSCDIAASR-----RGVLVEHL--CQ------HSGVCINAGNTHYCQC 1137

Query: 983  PEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVP-----GKFRMDACCCAVGAAWGTEC 1037
            P G     TG  C + ++++C      + C H        G +R   C C  G   G  C
Sbjct: 1138 PLGY----TGSYC-EEQLDEC----ASNPCQHGATCSDFIGGYR---CECVPGYQ-GVNC 1184

Query: 1038 E---------ECPKPGT-----KEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGM 1083
            E          C   GT       ++  CP G           G    ++I++C   P  
Sbjct: 1185 EYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGT---------RGLLCEENIDDCARGPHC 1235

Query: 1084 CTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISP-DLCGSGICVNTPGSFECEC 1142
               G+C + IG + CRC  GFA    ER   DI+EC  +P    GS  C+     + C C
Sbjct: 1236 LNGGQCMDRIGGYSCRCLPGFA---GERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVC 1292

Query: 1143 FEGYESGFMMMKNCMD-IDECERNPLLCRGGTCV---NTEGSFQCDCPLGHELSPSREDC 1198
               +       ++C   +D C + P L  GGTC    N    F C CP G   +  +  C
Sbjct: 1293 RSAFTG-----RHCETFVDVCPQMPCL-NGGTCAVASNMPDGFICRCPPGFSGARCQSSC 1346

Query: 1199 VDINECSLSDNLCRNG-KCVNMIGTYQC------SCNPGYQATPDRQGCTDIDECMIMNG 1251
              +         CR G +CV+     +C       C  G  ++P + G           G
Sbjct: 1347 GQVK--------CRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHG-----------G 1387

Query: 1252 GCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNP----------DICDGGQCTN 1301
             C  Q       Y C C+  ++    G  C       + P          D    G C  
Sbjct: 1388 SCHPQ--RQPPYYSCQCAPPFS----GSRCELYTAPPSTPPATCLSQYCADKARDGVCDE 1441

Query: 1302 IPGEYRCLCYDGFMASMDMKT----------CIDV--NECD--LNSNICMFGECENTKGS 1347
                + C  +DG   S+ M+           C D   N+CD   N+  C+F   E    S
Sbjct: 1442 ACNSHACQ-WDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQGNS 1500

Query: 1348 FIC----HCQLGYSVKKGTTGCTDVDECEIGAHNC 1378
              C    +C   +       GC   +EC     +C
Sbjct: 1501 KTCKYDKYCADHFKDNHCDQGCNS-EECGWDGLDC 1534


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  473 bits (1218), Expect = e-133
 Identities = 464/1657 (28%), Positives = 663/1657 (40%), Gaps = 344/1657 (20%)

Query: 1123 PDLCGSGICVNTPGSF-----ECECFEGYES----GFMMMKNCMDIDECERNPLLCRG-G 1172
            P L   G   + PG       +CE   G E+    G  +   C D + C   P  C+  G
Sbjct: 15   PALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTP--CKNAG 72

Query: 1173 TC--VNTEG--SFQCDCPLGHE----LSPSREDCVDINECSLSDNLCRNGKCVNMIGT-- 1222
            TC  V+  G   + C C LG      L+P    C+         N CRNG   +++    
Sbjct: 73   TCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLT--------NPCRNGGTCDLLTLTE 124

Query: 1223 YQCSCNPGYQATPDRQGCTDIDECM---IMNGGCDTQCTNSEGSYECSCSEGYALMPDGR 1279
            Y+C C PG+      + C   D C      NGG   QC   E SY C C   +     G 
Sbjct: 125  YKCRCPPGWSG----KSCQQADPCASNPCANGG---QCLPFEASYICHCPPSF----HGP 173

Query: 1280 SCA-DIDECENNPDIC-DGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICM 1337
            +C  D++EC   P +C  GG C N  G YRC+C          +  +  +     +    
Sbjct: 174  TCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNG--- 230

Query: 1338 FGECENTKG-SFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCR 1396
             G C  T   +  C C  G++   G     ++D+C    +NC    +C++   ++ C C 
Sbjct: 231  -GTCRPTGDVTHECACLPGFT---GQNCEENIDDCP--GNNCKNGGACVDGVNTYNCRCP 284

Query: 1397 EGWIGNGIKCI-DLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAE 1455
              W G    C  D+DEC    + C     C NT G Y C C  G+TG        ++C+E
Sbjct: 285  PEWTGQ--YCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTG--------EDCSE 334

Query: 1456 NINLCENGQCLNVP------GAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGT-CNN 1508
            NI+ C +  C +         ++ CEC  G T       C   D C   N C  G+ C+ 
Sbjct: 335  NIDDCASAACFHGATCHDRVASFYCECPHGRT----GLLCHLNDAC-ISNPCNEGSNCDT 389

Query: 1509 LP--GMFHCICDDGYELDRTGGNCT-DIDECADPIN-CVN-GLCVNTPGRYECNCPPDFQ 1563
             P  G   C C  GY    TG  C+ D+DEC+   N C + G C+NT G +EC C   + 
Sbjct: 390  NPVNGKAICTCPSGY----TGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYT 445

Query: 1564 LNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCE---T 1620
                                GPR      C  ++   VS             NPC+   T
Sbjct: 446  --------------------GPR------CEIDVNECVS-------------NPCQNDAT 466

Query: 1621 CPPVNSTEYYTLC-PGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQ 1679
            C      E+  +C PG EG      T      DEC   P L   G C++    FQCECP 
Sbjct: 467  CLD-QIGEFQCICMPGYEGVHCEVNT------DECASSPCL-HNGRCLDKINEFQCECPT 518

Query: 1680 GYYLSEDTRICE-DIDECFAHPGVCGPGT-CYNTLGNYTCICPPEYMQVNGGHNCMDMRK 1737
            G+       +C+ D+DEC + P  C  G  C +    YTC+C   Y    G H  +D+ +
Sbjct: 519  GF----TGHLCQYDVDECASTP--CKNGAKCLDGPNTYTCVCTEGY---TGTHCEVDIDE 569

Query: 1738 SFCYRSYNGTTCENELPFNVTKRMCC----CTYNVGKAWNKPCEPCPTPGTADFKTICGN 1793
                  + G+  +    F    R       C  N+ +  ++PC    T    D   +C  
Sbjct: 570  CDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFC 629

Query: 1794 IPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCE-DID 1852
            + G T        +++D+C   P  C +G C+++I  + C C  G++ +    +C  +ID
Sbjct: 630  LKGTT---GPNCEINLDDCASSP--CDSGTCLDKIDGYECACEPGYTGS----MCNINID 680

Query: 1853 ECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDR-NECLEIPNVCSHGLCVDL 1911
            EC+   N C     C +    + C C  G+    +  C+   NEC    N C HG C D 
Sbjct: 681  ECAG--NPCHNGGTCEDGINGFTCRCPEGYH---DPTCLSEVNECNS--NPCVHGACRDS 733

Query: 1912 QGSYQCICHNGFKASQDQTMC-MDVDECERHPCGN-GTCKNTVGSYNCLCYPGFELTHNN 1969
               Y+C C  G+      T C ++ +ECE +PC N GTCK+    Y C C  GF  +  N
Sbjct: 734  LNGYKCDCDPGWSG----TNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGF--SGPN 787

Query: 1970 DCLDIDECSSFFGQVCRN-GRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCS 2028
               +I+EC+S     C N G C +++  +KC C   Y     G  C    E V  P + S
Sbjct: 788  CQTNINECAS---NPCLNQGTCIDDVAGYKCNCLLPY----TGATC----EVVLAPCAPS 836

Query: 2029 P----GTCQNLEG--SFRCICPPGYEVKSENC-IDINECDEDPNICLFG-SCTNTPGGFQ 2080
            P    G C+  E   SF C+CP G++   + C +DINEC   P  C  G SC NT GG++
Sbjct: 837  PCRNGGECRQSEDYESFSCVCPTGWQ--GQTCEVDINECVLSP--CRHGASCQNTHGGYR 892

Query: 2081 CLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPC 2140
            C C  G+    +GR         C T+ ++                 C   P    G   
Sbjct: 893  CHCQAGY----SGRN--------CETDIDD-----------------CRPNPCHNGGS-- 921

Query: 2141 ELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNG-QCINTDGSFRCECP 2199
              C      AF D  P   GT        ED+NEC   P  C NG  C +   S+ C CP
Sbjct: 922  --CTDGINTAFCDCLPGFRGTF-----CEEDINECASDP--CRNGANCTDCVDSYTCTCP 972

Query: 2200 MGYNLDYTGVRCV-DTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECA 2258
             G    ++G+ C  +T +C+  +    GTC + I SF C C  GF      +  D+NEC 
Sbjct: 973  AG----FSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQH--DVNECD 1026

Query: 2259 QNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCES----RGMMCKN 2314
              P L    C +  GSY CTCP GY              C   +H C+S     G  C  
Sbjct: 1027 SQPCLHGGTCQDGCGSYRCTCPQGYT----------GPNCQNLVHWCDSSPCKNGGKCWQ 1076

Query: 2315 LIGTFMCICPPGMARRPDGEGCVDENECRTKPGI-----CEN-GRCVNIIGSYRCECNEG 2368
                + C CP G          V       + G+     C++ G CV+   ++ C C  G
Sbjct: 1077 THTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAG 1136

Query: 2369 FQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLP 2428
            +    +G+ C D        E   + CQ  ++  + +    C C  G             
Sbjct: 1137 Y----TGSYCED-----LVDECSPSPCQNGATCTDYLGGYSCKCVAGY------------ 1175

Query: 2429 GTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTN-GQCINTMGSFRCFCKVGYTTDISGT 2487
                      HG        +IDEC   P  C N G C++   +++C C  G      G 
Sbjct: 1176 ----------HG---VNCSEEIDECLSHP--CQNGGTCLDLPNTYKCSCPRG----TQGV 1216

Query: 2488 SC-IDLDEC-------SQSPKPC--NYICKNTEGSYQCSCPRGYVLQEDGKTCK-DLDEC 2536
             C I++D+C       S+SPK C  N  C +  G Y C+CP G+V    G+ C+ D++EC
Sbjct: 1217 HCEINVDDCNPPVDPVSRSPK-CFNNGTCVDQVGGYSCTCPPGFV----GERCEGDVNEC 1271

Query: 2537 QTKQHNCQFL--CVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGS 2594
             +   + +    CV  +  F C+C  G T      + N   G      G   +  NT   
Sbjct: 1272 LSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARG 1331

Query: 2595 FSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILG--GYRCGCPQGY----IQHYQ 2648
            F C+C  GF     G  CE+     G+ RC +G   I G     C C   +     Q   
Sbjct: 1332 FICKCPAGFE----GATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPA 1387

Query: 2649 WNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFS 2685
             + C+  N C N   C   S       Y+C CP+ F+
Sbjct: 1388 SSPCLGGNPCYNQGTCEPTS---ESPFYRCLCPAKFN 1421



 Score =  462 bits (1189), Expect = e-129
 Identities = 429/1487 (28%), Positives = 602/1487 (40%), Gaps = 343/1487 (23%)

Query: 1412 CSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCEN-GQCLNVP- 1469
            CS     C    +C    G+  C C   F G    C D + C      C+N G C  V  
Sbjct: 24   CSQPGETCLNGGKCEAANGTEACVCGGAFVGP--RCQDPNPCLSTP--CKNAGTCHVVDR 79

Query: 1470 ---GAYRCECEMGFTPASDSRSCQDIDECSFQNICVFG-TCNNLP-GMFHCICDDGYELD 1524
                 Y C C +GF   S       +D     N C  G TC+ L    + C C  G+   
Sbjct: 80   RGVADYACSCALGF---SGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGW--- 133

Query: 1525 RTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFG 1584
             +G +C   D CA       G C+     Y C+CPP F     G  C  + V  C  K G
Sbjct: 134  -SGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFH----GPTCRQD-VNECGQKPG 187

Query: 1585 PRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGN-----------PCE---TCPPVNSTEYY 1630
                G  +C+ E+G       C C       N           PC+   TC P     + 
Sbjct: 188  LCRHGG-TCHNEVG----SYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHE 242

Query: 1631 TLC-PGGEGFRPNPITIILEDIDECQELPGL-CQ-GGNCINTFGSFQCECPQ---GYYLS 1684
              C PG  G          E+ID+C   PG  C+ GG C++   ++ C CP    G Y +
Sbjct: 243  CACLPGFTGQNCE------ENIDDC---PGNNCKNGGACVDGVNTYNCRCPPEWTGQYCT 293

Query: 1685 EDTRICEDIDECFAHPGVC-GPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRS 1743
            ED      +DEC   P  C   GTC+NT G Y C+C   +   +   N  D   + C+  
Sbjct: 294  ED------VDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACF-- 345

Query: 1744 YNGTTCEN-------ELPFNVTKRMC-----CCTYNVGKAWNKPCEPCPTPGTADFKTIC 1791
             +G TC +       E P   T  +C     C +    +  N  C+  P  G    K IC
Sbjct: 346  -HGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSN--CDTNPVNG----KAIC 398

Query: 1792 GNIPGFTFDIHTGKAV--DIDECKEIPGICAN-GVCINQIGSFRCECPTGFSYNDLLLVC 1848
                G+T     G A   D+DEC      C + G CIN +GSF C+C  G++       C
Sbjct: 399  TCPSGYT-----GPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPR----C 449

Query: 1849 E-DIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGAC-VDRNECLEIPNVCSH- 1905
            E D++EC +  N CQ +A C++  G ++C C  G++      C V+ +EC   P  C H 
Sbjct: 450  EIDVNECVS--NPCQNDATCLDQIGEFQCICMPGYE---GVHCEVNTDECASSP--CLHN 502

Query: 1906 GLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGT-CKNTVGSYNCLCYPGFE 1964
            G C+D    +QC C  GF     Q    DVDEC   PC NG  C +   +Y C+C  G+ 
Sbjct: 503  GRCLDKINEFQCECPTGFTGHLCQ---YDVDECASTPCKNGAKCLDGPNTYTCVCTEGYT 559

Query: 1965 LTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNC-IDTNECVAL 2023
             TH    +DIDEC       C  G C + + +F CLC  GY     G +C  + NEC + 
Sbjct: 560  GTHCE--VDIDECDP---DPCHYGSCKDGVATFTCLCRPGYT----GHHCETNINECSSQ 610

Query: 2024 PGSCSPGTCQNLEGSFRCICPPGYEVKSENC-IDINECDEDPNICLFGSCTNTPGGFQCL 2082
            P     GTCQ+ + ++ C C  G      NC I++++C   P  C  G+C +   G++C 
Sbjct: 611  PCRHG-GTCQDRDNAYLCFCLKG--TTGPNCEINLDDCASSP--CDSGTCLDKIDGYECA 665

Query: 2083 CPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCEL 2142
            C PG+              S C  N +                  C+  P    G  CE 
Sbjct: 666  CEPGYT------------GSMCNINIDE-----------------CAGNPCHN-GGTCE- 694

Query: 2143 CPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGY 2202
               D    F   CP G+     L     +VNEC  +P  C +G C ++   ++C+C  G+
Sbjct: 695  ---DGINGFTCRCPEGYHDPTCL----SEVNECNSNP--CVHGACRDSLNGYKCDCDPGW 745

Query: 2203 NLDYTGVRC-VDTDECSIGNPCGNG-TCTNVIGSFECNCNEGFEPGPMMNCE-DINECAQ 2259
            +    G  C ++ +EC   NPC NG TC ++   + C C EGF  GP  NC+ +INECA 
Sbjct: 746  S----GTNCDINNNECE-SNPCVNGGTCKDMTSGYVCTCREGFS-GP--NCQTNINECAS 797

Query: 2260 NPLLCAFRCMNTFGSYECTCPIGYALREDQKM--------CKDLDECAEGLHDCESRGMM 2311
            NP L    C++    Y+C C + Y     + +        C++  EC +   D ES    
Sbjct: 798  NPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQS-EDYES---- 852

Query: 2312 CKNLIGTFMCICPPGMARRPDGEGC-VDENECRTKPGICENGR-CVNIIGSYRCECNEGF 2369
                   F C+CP G      G+ C VD NEC   P  C +G  C N  G YRC C  G+
Sbjct: 853  -------FSCVCPTGW----QGQTCEVDINECVLSP--CRHGASCQNTHGGYRCHCQAGY 899

Query: 2370 QSSSSGTECLDNRQGLC-----------------------------FAEVLQTICQMASS 2400
               +  T+  D R   C                               E     C+  ++
Sbjct: 900  SGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGAN 959

Query: 2401 SRNLVTKSECCCDGGRGWGHQCE---------------LCPLPGTAQYKKICPHGPGYTT 2445
              + V    C C  G   G  CE                C + G   +  +CP  PG+T 
Sbjct: 960  CTDCVDSYTCTCPAGFS-GIHCENNTPDCTESSCFNGGTC-VDGINSFTCLCP--PGFTG 1015

Query: 2446 D--GRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDE-CSQSPKPC 2502
                 D++EC   P L   G C +  GS+RC C  GYT    G +C +L   C  SP   
Sbjct: 1016 SYCQHDVNECDSQPCL-HGGTCQDGCGSYRCTCPQGYT----GPNCQNLVHWCDSSPCKN 1070

Query: 2503 NYICKNTEGSYQCSCPRGYV------------------------LQEDGKTCKD------ 2532
               C  T   Y+C CP G+                         L + G  C D      
Sbjct: 1071 GGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHH 1130

Query: 2533 ---------------LDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDN-NECG 2576
                           +DEC          C + LGG++CKC  G+  H   C +  +EC 
Sbjct: 1131 CRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGY--HGVNCSEEIDECL 1188

Query: 2577 SQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCE-DVDECDG-------NHRCQHG- 2627
            S P  C   G C + P ++ C C RG      G++CE +VD+C+        + +C +  
Sbjct: 1189 SHP--CQNGGTCLDLPNTYKCSCPRG----TQGVHCEINVDDCNPPVDPVSRSPKCFNNG 1242

Query: 2628 -CQNILGGYRCGCPQGYIQHYQWNQCV-DENEC-SNP-NACGSASCYNTLGSYKCACPSG 2683
             C + +GGY C CP G++      +C  D NEC SNP +A G+ +C   +  + C C +G
Sbjct: 1243 TCVDQVGGYSCTCPPGFVGE----RCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAG 1298

Query: 2684 FSFDQFSSACHDVNECSSSKNPCNYG-----CSNTEGGYLCGCPPGY 2725
             +  +  S    +N C     PC  G      SNT  G++C CP G+
Sbjct: 1299 HTGRRCESV---INGCKGK--PCKNGGTCAVASNTARGFICKCPAGF 1340



 Score =  448 bits (1153), Expect = e-125
 Identities = 491/1738 (28%), Positives = 683/1738 (39%), Gaps = 437/1738 (25%)

Query: 498  CKHHANLCLNG-RCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTN-GDC--VNTP 553
            C      CLNG +C     +  C C   +       C D + C S PC N G C  V+  
Sbjct: 24   CSQPGETCLNGGKCEAANGTEACVCGGAF---VGPRCQDPNPCLSTPCKNAGTCHVVDRR 80

Query: 554  G--SYYCKCHAGFQ----RTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFE 607
            G   Y C C  GF      TP   AC+  + C +NG  C     + T   ++C C  G+ 
Sbjct: 81   GVADYACSCALGFSGPLCLTPLDNACL-TNPC-RNGGTCD----LLTLTEYKCRCPPGW- 133

Query: 608  LTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYC-TDVDEC-QTP 665
                GK+C   D C +      G C+  + S+ C C P F    +G  C  DV+EC Q P
Sbjct: 134  ---SGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSF----HGPTCRQDVNECGQKP 186

Query: 666  GICMN-GHCINSEGSFRCDCPPGLAVGMDGRVCVDTHM---RSTCYGGIKKGVCVRPFPG 721
            G+C + G C N  GS+RC C         G  C   ++    S C  G   G C RP  G
Sbjct: 187  GLCRHGGTCHNEVGSYRCVC----RATHTGPNCERPYVPCSPSPCQNG---GTC-RP-TG 237

Query: 722  AVTKSECCCANPDYGF-GEPCQ----PCPAKNSAEFHGLCSSGVGITVDGR--------- 767
             VT  EC C     GF G+ C+     CP  N+ +  G C  GV  T + R         
Sbjct: 238  DVT-HECACLP---GFTGQNCEENIDDCPG-NNCKNGGACVDGVN-TYNCRCPPEWTGQY 291

Query: 768  ---DINECALDPDICAN-GICENLRGSYRCNCNSGYEPDASGRNCID-IDECLV------ 816
               D++EC L P+ C N G C N  G Y C C +G+    +G +C + ID+C        
Sbjct: 292  CTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGW----TGEDCSENIDDCASAACFHG 347

Query: 817  ------------------NRLLCD-NGLCRNTP-------------GSYSCTCPPGYVFR 844
                                LLC  N  C + P             G   CTCP GY   
Sbjct: 348  ATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGY--- 404

Query: 845  TETETCEDINECE--SNPCVN-GACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLN 901
            T     +D++EC   +NPC + G C N LGSF C+C  G     TG              
Sbjct: 405  TGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQG----YTG-------------- 446

Query: 902  IQDSRCEVNINGATLKSECCATLGAAWGSPCER---C-----ELDTACPRGLARIKGVTC 953
                RCE+++N      EC +       +PC+    C     E    C  G    +GV C
Sbjct: 447  ---PRCEIDVN------ECVS-------NPCQNDATCLDQIGEFQCICMPG---YEGVHC 487

Query: 954  E-DVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDEC 1012
            E + +EC   P    NGRC++    F CECP G     TG +C          ++D DEC
Sbjct: 488  EVNTDECASSP-CLHNGRCLDKINEFQCECPTGF----TGHLC----------QYDVDEC 532

Query: 1013 IHP--VPGKFRMD-----ACCCAVGAAWGTECE----ECP---------KPGTKEYETLC 1052
                   G   +D      C C  G   GT CE    EC          K G   +  LC
Sbjct: 533  ASTPCKNGAKCLDGPNTYTCVCTEGYT-GTHCEVDIDECDPDPCHYGSCKDGVATFTCLC 591

Query: 1053 PRGAGFANRGDVLTGRPFYKDINECKAFPGMCTY-GKCRNTIGSFKCRCNSGFALDMEER 1111
              G          TG     +INEC + P  C + G C++   ++ C C  G        
Sbjct: 592  RPG---------YTGHHCETNINECSSQP--CRHGGTCQDRDNAYLCFCLKG----TTGP 636

Query: 1112 NC-TDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCR 1170
            NC  ++D+C  SP  C SG C++    +EC C  GY +G M   N   IDEC  NP    
Sbjct: 637  NCEINLDDCASSP--CDSGTCLDKIDGYECACEPGY-TGSMCNIN---IDECAGNP-CHN 689

Query: 1171 GGTCVNTEGSFQCDCPLGHELSPSREDCV-DINECSLSDNLCRNGKCVNMIGTYQCSCNP 1229
            GGTC +    F C CP G+   P+   C+ ++NEC  + N C +G C + +  Y+C C+P
Sbjct: 690  GGTCEDGINGFTCRCPEGYH-DPT---CLSEVNEC--NSNPCVHGACRDSLNGYKCDCDP 743

Query: 1230 GYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC-ADIDECE 1288
            G+  T       + +    +NGG    C +    Y C+C EG++    G +C  +I+EC 
Sbjct: 744  GWSGTNCDINNNECESNPCVNGG---TCKDMTSGYVCTCREGFS----GPNCQTNINECA 796

Query: 1289 NNPDICDGGQCTNIPGEYRCLC---YDGFMASMDMKTC---------------------- 1323
            +NP + + G C +    Y+C C   Y G    + +  C                      
Sbjct: 797  SNPCL-NQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSC 855

Query: 1324 ------------IDVNECDLNSNICMFG-ECENTKGSFICHCQLGYSVKKGTTGCTDVDE 1370
                        +D+NEC L+   C  G  C+NT G + CHCQ GYS   G    TD+D+
Sbjct: 856  VCPTGWQGQTCEVDINECVLSP--CRHGASCQNTHGGYRCHCQAGYS---GRNCETDIDD 910

Query: 1371 CEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPG 1430
            C    + C    SC +   +  C C  G+ G   +  D++EC+  +  C   A C +   
Sbjct: 911  CR--PNPCHNGGSCTDGINTAFCDCLPGFRGTFCE-EDINECA--SDPCRNGANCTDCVD 965

Query: 1431 SYRCACSEGFTGDGFTC-SDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSC 1489
            SY C C  GF+  G  C ++  +C E+ +    G C++   ++ C C  GFT       C
Sbjct: 966  SYTCTCPAGFS--GIHCENNTPDCTES-SCFNGGTCVDGINSFTCLCPPGFT----GSYC 1018

Query: 1490 Q-DIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVN-GLC 1547
            Q D++EC  Q     GTC +  G + C C  GY    TG NC ++    D   C N G C
Sbjct: 1019 QHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGY----TGPNCQNLVHWCDSSPCKNGGKC 1074

Query: 1548 VNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEI---GVGVSRS 1604
              T  +Y C CP  +    TG+ C                  S+SC       GV V+R 
Sbjct: 1075 WQTHTQYRCECPSGW----TGLYC---------------DVPSVSCEVAAQRQGVDVAR- 1114

Query: 1605 SCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQ-G 1663
               C  G         C    +T +     G  G      +   + +DEC   P  CQ G
Sbjct: 1115 --LCQHG-------GLCVDAGNTHHCRCQAGYTG------SYCEDLVDECS--PSPCQNG 1157

Query: 1664 GNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEY 1723
              C +  G + C+C  GY+        E+IDEC +HP   G GTC +    Y C CP   
Sbjct: 1158 ATCTDYLGGYSCKCVAGYH---GVNCSEEIDECLSHPCQNG-GTCLDLPNTYKCSCPRGT 1213

Query: 1724 MQVNGGHNCMDMRK-----SFCYRSYNGTTCENEL--------PFNVTKRMCCCTYNVGK 1770
              V+   N  D        S   + +N  TC +++        P  V +R   C  +V +
Sbjct: 1214 QGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGER---CEGDVNE 1270

Query: 1771 AWNKPCEPCPTPGTA----DFKTICGNIPGFTFDIHTGKAVD--IDECKEIPGICANG-- 1822
              + PC+   T        DF   C          HTG+  +  I+ CK  P  C NG  
Sbjct: 1271 CLSNPCDARGTQNCVQRVNDFHCECR-------AGHTGRRCESVINGCKGKP--CKNGGT 1321

Query: 1823 --VCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAA 1880
              V  N    F C+CP GF        CE+ D  + G   C     CI+ P S  C C  
Sbjct: 1322 CAVASNTARGFICKCPAGFEG----ATCEN-DARTCGSLRCLNGGTCISGPRSPTCLCLG 1376

Query: 1881 GF-----KLSPNGACVDRNECLEIPNVCSHGLCVDLQGS--YQCICHNGFK--------- 1924
             F     +   +  C+  N C       + G C     S  Y+C+C   F          
Sbjct: 1377 PFTGPECQFPASSPCLGGNPCY------NQGTCEPTSESPFYRCLCPAKFNGLLCHILDY 1430

Query: 1925 -----ASQDQTMCMDVDECERHPC----GNGTCKNTVGSYNCLCYPGFELTHNND----C 1971
                 A +D    +  + CE   C    GN  C     ++ C    G    + ND    C
Sbjct: 1431 SFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNC 1490

Query: 1972 LDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSP 2029
                +C  +F     +G C ++  S  CL               D  +C    G C+P
Sbjct: 1491 TQSLQCWKYFS----DGHCDSQCNSAGCL--------------FDGFDCQRAEGQCNP 1530



 Score =  421 bits (1082), Expect = e-117
 Identities = 394/1327 (29%), Positives = 536/1327 (40%), Gaps = 264/1327 (19%)

Query: 1536 CADP-INCVNG-LCVNTPGRYECNCPPDFQLNPTGVGCVD---------NRVGNCYLKFG 1584
            C+ P   C+NG  C    G   C C   F     G  C D            G C++   
Sbjct: 24   CSQPGETCLNGGKCEAANGTEACVCGGAF----VGPRCQDPNPCLSTPCKNAGTCHV-VD 78

Query: 1585 PRGDGSLSCNTEIGVGVSRSSCCCSLGKAW-GNPCE---TCPPVNSTEYYTLCPGGEGFR 1640
             RG    +C+  +G   S   C   L  A   NPC    TC  +  TEY   CP G   +
Sbjct: 79   RRGVADYACSCALGF--SGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGK 136

Query: 1641 PNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHP 1700
                    +  D C   P    GG C+    S+ C CP  ++        +D++EC   P
Sbjct: 137  S------CQQADPCASNP-CANGGQCLPFEASYICHCPPSFH---GPTCRQDVNECGQKP 186

Query: 1701 GVCGPG-TCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTK 1759
            G+C  G TC+N +G+Y C+C   +     G NC                   E P+    
Sbjct: 187  GLCRHGGTCHNEVGSYRCVCRATHT----GPNC-------------------ERPY---- 219

Query: 1760 RMCCCTYNVGKAWNKPCEPCPTPG------TADFKTICGNIPGFTFDIHTGKAVDIDECK 1813
                           PC P P         T D    C  +PGFT         +ID+C 
Sbjct: 220  --------------VPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQ---NCEENIDDC- 261

Query: 1814 EIPGI-CANG-VCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSP 1871
              PG  C NG  C++ + ++ C CP  ++        ED+DEC    N CQ    C N+ 
Sbjct: 262  --PGNNCKNGGACVDGVNTYNCRCPPEWTGQ---YCTEDVDECQLMPNACQNGGTCHNTH 316

Query: 1872 GSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGL-CVDLQGSYQCICHNGFKASQDQT 1930
            G Y C C  G+        +D  +C      C HG  C D   S+ C C +G    +   
Sbjct: 317  GGYNCVCVNGWTGEDCSENID--DCASA--ACFHGATCHDRVASFYCECPHG----RTGL 368

Query: 1931 MCMDVDECERHPCGNGTCKNTV---GSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRN 1987
            +C   D C  +PC  G+  +T    G   C C  G+  T      D+DECS         
Sbjct: 369  LCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGY--TGPACSQDVDECSLGANPCEHA 426

Query: 1988 GRCFNEIGSFKCLCNEGYELTPDGKNC-IDTNECVALPGSCSPGTCQNLEGSFRCICPPG 2046
            G+C N +GSF+C C +GY     G  C ID NECV+ P   +  TC +  G F+CIC PG
Sbjct: 427  GKCINTLGSFECQCLQGYT----GPRCEIDVNECVSNPCQ-NDATCLDQIGEFQCICMPG 481

Query: 2047 YEVKSENC-IDINECDEDPNICLF-GSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFC 2104
            YE    +C ++ +EC   P  CL  G C +    FQC CP GF     G  C        
Sbjct: 482  YE--GVHCEVNTDECASSP--CLHNGRCLDKINEFQCECPTGFT----GHLCQYDVDECA 533

Query: 2105 FTNFENG-KCSVPKAFNTTKAKCC-------CSKMPGEGWGDPCELCPKDDEVA-FQDLC 2155
             T  +NG KC      NT    C        C     E   DPC      D VA F  LC
Sbjct: 534  STPCKNGAKCL--DGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLC 591

Query: 2156 PYGHGTVPSLHDTREDVNECLESPGICSNG-QCINTDGSFRCECPMGYNLDYTGVRC-VD 2213
              G+    + H    ++NEC   P  C +G  C + D ++ C C  G     TG  C ++
Sbjct: 592  RPGY----TGHHCETNINECSSQP--CRHGGTCQDRDNAYLCFCLKGT----TGPNCEIN 641

Query: 2214 TDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFG 2273
             D+C+  +PC +GTC + I  +EC C  G+  G M N  +I+ECA NP      C +   
Sbjct: 642  LDDCA-SSPCDSGTCLDKIDGYECACEPGYT-GSMCNI-NIDECAGNPCHNGGTCEDGIN 698

Query: 2274 SYECTCPIGYALREDQKMCKDLDECAEG--LHDCESRGMMCKNLIGTFMCICPPGMARRP 2331
             + C CP GY    D     +++EC     +H        C++ +  + C C PG +   
Sbjct: 699  GFTCRCPEGY---HDPTCLSEVNECNSNPCVHGA------CRDSLNGYKCDCDPGWS--- 746

Query: 2332 DGEGC-VDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGT---ECLDN---RQG 2384
             G  C ++ NEC + P +   G C ++   Y C C EGF   +  T   EC  N    QG
Sbjct: 747  -GTNCDINNNECESNPCV-NGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQG 804

Query: 2385 LCFAEVLQTICQMA---SSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGP 2441
             C  +V    C      + +   V  + C     R  G   E         +  +CP G 
Sbjct: 805  TCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGG---ECRQSEDYESFSCVCPTGW 861

Query: 2442 GYTTDGRDIDECKVMPNLCTNG-QCINTMGSFRCFCKVGYTTDISGTSC-IDLDECSQSP 2499
               T   DI+EC + P  C +G  C NT G +RC C+ GY    SG +C  D+D+C   P
Sbjct: 862  QGQTCEVDINECVLSP--CRHGASCQNTHGGYRCHCQAGY----SGRNCETDIDDCR--P 913

Query: 2500 KPCNYICKNTEG--SYQCSCPRGYVLQEDGKTCK-DLDECQTKQHNCQFLCVNTLGGFTC 2556
             PC+     T+G  +  C C  G+     G  C+ D++EC +        C + +  +TC
Sbjct: 914  NPCHNGGSCTDGINTAFCDCLPGF----RGTFCEEDINECASDPCRNGANCTDCVDSYTC 969

Query: 2557 KCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCE-DV 2615
             CP GF+  H    +NN      S C   G C +   SF+C C  GF    TG  C+ DV
Sbjct: 970  TCPAGFSGIHC---ENNTPDCTESSCFNGGTCVDGINSFTCLCPPGF----TGSYCQHDV 1022

Query: 2616 DECDGNHRCQHG--CQNILGGYRCGCPQGYIQHYQWN--QCVDENECSNPNACGSASCYN 2671
            +ECD +  C HG  CQ+  G YRC CPQGY      N     D + C N        C+ 
Sbjct: 1023 NECD-SQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKN-----GGKCWQ 1076

Query: 2672 TLGSYKCACPSGFS------------------------FDQFSSACHD------------ 2695
            T   Y+C CPSG++                          Q    C D            
Sbjct: 1077 THTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAG 1136

Query: 2696 ---------VNECSSSKNPCNYG--CSNTEGGYLCGCPPGYYRVGQG----HCVSGMGFN 2740
                     V+ECS S  PC  G  C++  GGY C C  GY+ V        C+S    N
Sbjct: 1137 YTGSYCEDLVDECSPS--PCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQN 1194

Query: 2741 KGQYLSL 2747
             G  L L
Sbjct: 1195 GGTCLDL 1201



 Score =  405 bits (1042), Expect = e-112
 Identities = 433/1582 (27%), Positives = 602/1582 (38%), Gaps = 364/1582 (23%)

Query: 153  CMNGGTC----ADDHCQCQKGYIGTYCGQP--VCENGCQNGGRC-------IGPNRCACV 199
            C+NGG C      + C C   ++G  C  P       C+N G C       +    C+C 
Sbjct: 31   CLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA 90

Query: 200  YGFTGPQC----ERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMC- 254
             GF+GP C    +    T PC          G    +  T+  C    G + G  C+   
Sbjct: 91   LGFSGPLCLTPLDNACLTNPCRN-------GGTCDLLTLTEYKCRCPPGWS-GKSCQQAD 142

Query: 255  PAQPQPCRRG---------FI----PNIRTGAC-QDVDECQAIPGICQ-GGNCINTVGSF 299
            P    PC  G         +I    P+     C QDV+EC   PG+C+ GG C N VGS+
Sbjct: 143  PCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSY 202

Query: 300  ECRCPAGHKQSETTQKCE-DIDECSIIPGICETGECSNTVG--SYFCVCPRGY------- 349
             C C A H    T   CE     CS  P  C+ G      G  ++ C C  G+       
Sbjct: 203  RCVCRATH----TGPNCERPYVPCS--PSPCQNGGTCRPTGDVTHECACLPGFTGQNCEE 256

Query: 350  -VTSTDGSRCIDQRTGMCFSGL--VNGRCAQELPGRMTKM---QCCCEPGRCWGIGTIPE 403
             +    G+ C  +  G C  G+   N RC  E  G+       +C   P  C   GT   
Sbjct: 257  NIDDCPGNNC--KNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHN 314

Query: 404  ACPVRGSEEYRRLCMDGLPMGGIP------GSAGSRPGGTGGNGFA------PSGNGNGY 451
                     Y  +C++G              SA    G T  +  A      P G     
Sbjct: 315  T-----HGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLL 369

Query: 452  GPGGTGFIPIP---GGNGFSPGVGGAGV---GAGGQGPIITGLTILNQTIDICKHHANLC 505
                   I  P   G N  +  V G  +    +G  GP        +Q +D C   AN C
Sbjct: 370  CHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGP------ACSQDVDECSLGANPC 423

Query: 506  LN-GRCIPTVSSYRCECNMGYKQDANGDC-IDVDECTSNPCTN-GDCVNTPGSYYCKCHA 562
             + G+CI T+ S+ C+C  GY       C IDV+EC SNPC N   C++  G + C C  
Sbjct: 424  EHAGKCINTLGSFECQCLQGY---TGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMP 480

Query: 563  GFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNC-VDHDEC 621
            G++    +   ++ DEC  +  L  NGRC++    FQC C  GF     G  C  D DEC
Sbjct: 481  GYEGVHCE---VNTDECASSPCL-HNGRCLDKINEFQCECPTGF----TGHLCQYDVDEC 532

Query: 622  TTTNMCLNG-MCINEDGSFKCICKPGFVLAPNGRYC-TDVDECQTPGICMNGHCINSEGS 679
             +T  C NG  C++   ++ C+C  G+     G +C  D+DEC  P  C  G C +   +
Sbjct: 533  AST-PCKNGAKCLDGPNTYTCVCTEGY----TGTHCEVDIDECD-PDPCHYGSCKDGVAT 586

Query: 680  FRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGE 739
            F C C PG      G  C +T++                       +EC          +
Sbjct: 587  FTCLCRPGYT----GHHC-ETNI-----------------------NECS--------SQ 610

Query: 740  PCQPCPAKNSAEFHGLCSSGVGITVDGRDIN--ECALDPDICANGICENLRGSYRCNCNS 797
            PC+        +   LC    G T    +IN  +CA  P  C +G C +    Y C C  
Sbjct: 611  PCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSP--CDSGTCLDKIDGYECACEP 668

Query: 798  GYEPDASGRNC-IDIDECLVNRLLCDN-GLCRNTPGSYSCTCPPGYVFRTETETC-EDIN 854
            GY    +G  C I+IDEC  N   C N G C +    ++C CP GY       TC  ++N
Sbjct: 669  GY----TGSMCNINIDECAGNP--CHNGGTCEDGINGFTCRCPEGY----HDPTCLSEVN 718

Query: 855  ECESNPCVNGACRNNLGSFNCECSPG--------------SKLSSTGLICIDSLKG---T 897
            EC SNPCV+GACR++L  + C+C PG              S     G  C D   G   T
Sbjct: 719  ECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCT 778

Query: 898  CWLNIQDSRCEVNING----------------ATLKSEC---------------CATLGA 926
            C        C+ NIN                 A  K  C               CA    
Sbjct: 779  CREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPC 838

Query: 927  AWGSPCERCE----LDTACPRGLARIKGVTCE-DVNECEVFPGVCPNG-RCVNSKGSFHC 980
              G  C + E        CP G    +G TCE D+NEC + P  C +G  C N+ G + C
Sbjct: 839  RNGGECRQSEDYESFSCVCPTGW---QGQTCEVDINECVLSP--CRHGASCQNTHGGYRC 893

Query: 981  ECPEGLTLDGTGRVCL----DIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTE 1036
             C  G     +GR C     D R   C+   +   C   +   F    C C  G   GT 
Sbjct: 894  HCQAGY----SGRNCETDIDDCRPNPCH---NGGSCTDGINTAF----CDCLPGFR-GTF 941

Query: 1037 CEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYG-KCRNTIGS 1095
            CEE                                 DINEC + P  C  G  C + + S
Sbjct: 942  CEE---------------------------------DINECASDP--CRNGANCTDCVDS 966

Query: 1096 FKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKN 1155
            + C C +GF+    E N  D  E          G CV+   SF C C  G+   +     
Sbjct: 967  YTCTCPAGFSGIHCENNTPDCTE----SSCFNGGTCVDGINSFTCLCPPGFTGSYCQ--- 1019

Query: 1156 CMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRN-G 1214
              D++EC+  P L  GGTC +  GS++C CP G+   P+ ++ V  + C  S   C+N G
Sbjct: 1020 -HDVNECDSQPCL-HGGTCQDGCGSYRCTCPQGY-TGPNCQNLV--HWCDSSP--CKNGG 1072

Query: 1215 KCVNMIGTYQCSCNPGY------------QATPDRQGCTDIDECMIMNGGCDTQCTNSEG 1262
            KC      Y+C C  G+            +    RQG      C   +GG    C ++  
Sbjct: 1073 KCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLC--QHGGL---CVDAGN 1127

Query: 1263 SYECSCSEGYALMPDGRSCAD-IDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMK 1321
            ++ C C  GY     G  C D +DEC  +P   +G  CT+  G Y C C  G+     + 
Sbjct: 1128 THHCRCQAGYT----GSYCEDLVDECSPSP-CQNGATCTDYLGGYSCKCVAGYHG---VN 1179

Query: 1322 TCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECE------IGA 1375
               +++EC L+      G C +   ++ C C  G    +G     +VD+C         +
Sbjct: 1180 CSEEIDEC-LSHPCQNGGTCLDLPNTYKCSCPRG---TQGVHCEINVDDCNPPVDPVSRS 1235

Query: 1376 HNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCA 1435
              C  + +C++  G + C+C  G++G   +  D++EC +          CV     + C 
Sbjct: 1236 PKCFNNGTCVDQVGGYSCTCPPGFVGERCEG-DVNECLSNPCDARGTQNCVQRVNDFHCE 1294

Query: 1436 CSEGFTGDGFTCSDVDECAENINLCENGQC---------LNVPGAYRCECEMGFTPASDS 1486
            C  G TG          C   IN C+   C          N    + C+C  GF    + 
Sbjct: 1295 CRAGHTG--------RRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGF----EG 1342

Query: 1487 RSCQ-DIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNC--TDIDECADPINCV 1543
             +C+ D   C        GTC + P    C+C   +    TG  C       C     C 
Sbjct: 1343 ATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPF----TGPECQFPASSPCLGGNPCY 1398

Query: 1544 N-GLCVNTPGR--YECNCPPDF 1562
            N G C  T     Y C CP  F
Sbjct: 1399 NQGTCEPTSESPFYRCLCPAKF 1420



 Score =  292 bits (748), Expect = 3e-78
 Identities = 355/1335 (26%), Positives = 501/1335 (37%), Gaps = 288/1335 (21%)

Query: 89   CGSRFHS-YC-CPGWKT---LPGGNQCIVPICR--NSCGDGFCSRPNMCTCSSGQISSTC 141
            C  R  S YC CP  +T       + CI   C   ++C     +   +CTC SG     C
Sbjct: 350  CHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPAC 409

Query: 142  GSKSIQQCSVR---CMNGGTCADD----HCQCQKGYIGTYCGQPVCE---NGCQNGGRC- 190
             S+ + +CS+    C + G C +      CQC +GY G  C   V E   N CQN   C 
Sbjct: 410  -SQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCL 468

Query: 191  --IGPNRCACVYGFTGPQCE---RDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGR 245
              IG  +C C+ G+ G  CE    +  + PC   ++N  C  ++    C           
Sbjct: 469  DQIGEFQCICMPGYEGVHCEVNTDECASSPC---LHNGRCLDKINEFQCE---------- 515

Query: 246  AWGHPCEMCPAQPQPCRRGFIPNIRTGACQ-DVDECQAIPGICQGG-NCINTVGSFECRC 303
                           C  GF  ++    CQ DVDEC + P  C+ G  C++   ++ C C
Sbjct: 516  ---------------CPTGFTGHL----CQYDVDECASTP--CKNGAKCLDGPNTYTCVC 554

Query: 304  PAGHKQSETTQKCE-DIDECSIIPGICETGECSNTVGSYFCVCPRGYV---TSTDGSRCI 359
              G+    T   CE DIDEC   P  C  G C + V ++ C+C  GY      T+ + C 
Sbjct: 555  TEGY----TGTHCEVDIDECD--PDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECS 608

Query: 360  DQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMD 419
             Q    C  G   G C      R     C C  G      T    C +   +     C  
Sbjct: 609  SQP---CRHG---GTCQD----RDNAYLCFCLKG------TTGPNCEINLDDCASSPCDS 652

Query: 420  GLPMGGIPG-SAGSRPGGTGG--NGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGV 476
            G  +  I G      PG TG   N       GN    GGT      G NGF+        
Sbjct: 653  GTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCE---DGINGFT-----CRC 704

Query: 477  GAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDV 536
              G   P  T L+ +N+       ++N C++G C  +++ Y+C+C+ G+    N D I+ 
Sbjct: 705  PEGYHDP--TCLSEVNEC------NSNPCVHGACRDSLNGYKCDCDPGW-SGTNCD-INN 754

Query: 537  DECTSNPCTN-GDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTD 595
            +EC SNPC N G C +    Y C C  GF   P  Q   +I+EC  N  L   G C++  
Sbjct: 755  NECESNPCVNGGTCKDMTSGYVCTCREGFS-GPNCQT--NINECASNPCL-NQGTCIDDV 810

Query: 596  GSFQCICNAGFELTTDGKNC-VDHDECTTTNMCLNGMCINEDG--SFKCICKPGFVLAPN 652
              ++C C     L   G  C V    C  +     G C   +   SF C+C  G+     
Sbjct: 811  AGYKCNC----LLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGW----Q 862

Query: 653  GRYC-TDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIK 711
            G+ C  D++EC          C N+ G +RC C      G  GR C              
Sbjct: 863  GQTCEVDINECVLSPCRHGASCQNTHGGYRCHC----QAGYSGRNC-------------- 904

Query: 712  KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINE 771
                        T  + C  NP +  G     C    +  F   C  G   T    DINE
Sbjct: 905  -----------ETDIDDCRPNPCHNGGS----CTDGINTAFCD-CLPGFRGTFCEEDINE 948

Query: 772  CALDPDICANGI-CENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTP 830
            CA DP  C NG  C +   SY C C +G+    SG +C +           + G C +  
Sbjct: 949  CASDP--CRNGANCTDCVDSYTCTCPAGF----SGIHCENNTPDCTESSCFNGGTCVDGI 1002

Query: 831  GSYSCTCPPGYVFRTETETCEDINECESNPCVN-GACRNNLGSFNCECSPGSKLSSTGLI 889
             S++C CPPG+   T +    D+NEC+S PC++ G C++  GS+ C C  G     TG  
Sbjct: 1003 NSFTCLCPPGF---TGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQG----YTGPN 1055

Query: 890  CIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCE-RCELDTACPRG---- 944
            C  +L   C                   S  C   G  W +  + RCE    CP G    
Sbjct: 1056 C-QNLVHWC------------------DSSPCKNGGKCWQTHTQYRCE----CPSGWTGL 1092

Query: 945  LARIKGVTCEDVNE---CEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRME 1001
               +  V+CE   +    +V       G CV++  + HC C  G     TG  C D+   
Sbjct: 1093 YCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGY----TGSYCEDL--- 1145

Query: 1002 QCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANR 1061
                    DEC    P   +  A C      +  +C                  AG+   
Sbjct: 1146 -------VDEC---SPSPCQNGATCTDYLGGYSCKCV-----------------AGY--- 1175

Query: 1062 GDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRC---NSGFALDMEERNCT-DID 1117
                 G    ++I+EC + P     G C +   ++KC C     G   ++   +C   +D
Sbjct: 1176 ----HGVNCSEEIDECLSHPCQ-NGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVD 1230

Query: 1118 ECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRG-GTCVN 1176
                SP    +G CV+  G + C C      GF+  +   D++EC  NP   RG   CV 
Sbjct: 1231 PVSRSPKCFNNGTCVDQVGGYSCTC----PPGFVGERCEGDVNECLSNPCDARGTQNCVQ 1286

Query: 1177 TEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRN-GKCV---NMIGTYQCSCNPGYQ 1232
                F C+C  GH  +  R + V IN C      C+N G C    N    + C C  G++
Sbjct: 1287 RVNDFHCECRAGH--TGRRCESV-INGC--KGKPCKNGGTCAVASNTARGFICKCPAGFE 1341

Query: 1233 ATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGY----ALMPDGRSCADIDECE 1288
                            +NGG    C +   S  C C   +       P    C   + C 
Sbjct: 1342 GATCENDARTCGSLRCLNGG---TCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCY 1398

Query: 1289 NNPDICDGGQC--TNIPGEYRCLC---YDGFMA-----SMDMKTCIDVNECDLNSNICMF 1338
            N       G C  T+    YRCLC   ++G +      S       D+    L    C  
Sbjct: 1399 NQ------GTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPP-PLIEEACEL 1451

Query: 1339 GECENTKGSFICHCQ 1353
             EC+   G+ +C  Q
Sbjct: 1452 PECQEDAGNKVCSLQ 1466



 Score =  130 bits (328), Expect = 1e-29
 Identities = 116/369 (31%), Positives = 157/369 (42%), Gaps = 63/369 (17%)

Query: 67  GAAVASRVRRRGQQDVL-RGPNVCGSRFHSYCCPGWKTLPGGN--QCIVPICRNSCGDGF 123
           G      V   GQ+  L R    C +   SY C    T  G N  +  VP   + C +G 
Sbjct: 172 GPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGG 231

Query: 124 CSRP-----NMCTCSSGQISSTCGSKSIQQC-SVRCMNGGTCADD----HCQCQKGYIGT 173
             RP     + C C  G     C  ++I  C    C NGG C D     +C+C   + G 
Sbjct: 232 TCRPTGDVTHECACLPGFTGQNC-EENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQ 290

Query: 174 YCGQPVCE-----NGCQNGGRCI---GPNRCACVYGFTGPQCERD---------YRTGPC 216
           YC + V E     N CQNGG C    G   C CV G+TG  C  +         +    C
Sbjct: 291 YCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATC 350

Query: 217 FTQVNNQMCQGQ--LTGIVCTKTLCCATIGRAWGHPCEMCPAQPQP---CRRGFIPNIRT 271
             +V +  C+     TG++C     C +     G  C+  P   +    C  G+     T
Sbjct: 351 HDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGY-----T 405

Query: 272 G-AC-QDVDECQAIPGICQ-GGNCINTVGSFECRCPAGHKQSETTQKCE-DIDECSIIPG 327
           G AC QDVDEC      C+  G CINT+GSFEC+C  G+    T  +CE D++EC   P 
Sbjct: 406 GPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGY----TGPRCEIDVNECVSNP- 460

Query: 328 ICET-GECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSG--LVNGRCAQELPGRMT 384
            C+    C + +G + C+C  GY    +G  C +  T  C S   L NGRC      ++ 
Sbjct: 461 -CQNDATCLDQIGEFQCICMPGY----EGVHC-EVNTDECASSPCLHNGRCLD----KIN 510

Query: 385 KMQCCCEPG 393
           + QC C  G
Sbjct: 511 EFQCECPTG 519



 Score =  122 bits (306), Expect = 5e-27
 Identities = 169/672 (25%), Positives = 231/672 (34%), Gaps = 134/672 (19%)

Query: 97   CCPGWKTL---PGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRC 153
            C PG++        N+C    CRN      C     CTC +G     C + +       C
Sbjct: 933  CLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSC 992

Query: 154  MNGGTCADD----HCQCQKGYIGTYCGQPVCE---NGCQNGGRC---IGPNRCACVYGFT 203
             NGGTC D      C C  G+ G+YC   V E     C +GG C    G  RC C  G+T
Sbjct: 993  FNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYT 1052

Query: 204  GPQCERDYR---TGPCFT-----QVNNQM---CQGQLTGIVC-TKTLCCATIGRAWG-HP 250
            GP C+       + PC       Q + Q    C    TG+ C   ++ C    +  G   
Sbjct: 1053 GPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDV 1112

Query: 251  CEMCPAQPQPCRRGFIPNIRTGA------CQD-VDECQAIPGICQ-GGNCINTVGSFECR 302
              +C         G   + R  A      C+D VDEC   P  CQ G  C + +G + C+
Sbjct: 1113 ARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECS--PSPCQNGATCTDYLGGYSCK 1170

Query: 303  CPAGHKQSETTQKCEDIDECSIIPGICET-GECSNTVGSYFCVCPRGYVTSTDGSRC--- 358
            C AG+     +   E+IDEC   P  C+  G C +   +Y C CPRG    T G  C   
Sbjct: 1171 CVAGYHGVNCS---EEIDECLSHP--CQNGGTCLDLPNTYKCSCPRG----TQGVHCEIN 1221

Query: 359  ID---------QRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG----RCWG--IGTIPE 403
            +D          R+  CF+   NG C  ++ G      C C PG    RC G     +  
Sbjct: 1222 VDDCNPPVDPVSRSPKCFN---NGTCVDQVGG----YSCTCPPGFVGERCEGDVNECLSN 1274

Query: 404  ACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGG--NGFAPSGNGNGYGPGGTGFIPI 461
             C  RG++   +   D             R G TG           G     GGT  +  
Sbjct: 1275 PCDARGTQNCVQRVND--------FHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVAS 1326

Query: 462  PGGNGF--SPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRC 519
                GF      G  G            L  LN    I    +  CL   C+   +   C
Sbjct: 1327 NTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCL---CLGPFTGPEC 1383

Query: 520  ECNMGYKQDANGDCIDVDECTSNPCTN-GDCVNTPGS--YYCKCHAGFQ----------- 565
            +        A+  C+       NPC N G C  T  S  Y C C A F            
Sbjct: 1384 QF------PASSPCLG-----GNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSF 1432

Query: 566  --------RTPTKQACIDIDECIQN------GVLCKNGRCVNTDGSFQCICNAGFELTTD 611
                      P  +   ++ EC ++       + C N  C    G     C+  F     
Sbjct: 1433 GGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGD----CSLNF--NDP 1486

Query: 612  GKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNG 671
             KNC    +C       +G C ++  S  C+   GF        C  + +        +G
Sbjct: 1487 WKNCTQSLQC--WKYFSDGHCDSQCNSAGCLF-DGFDCQRAEGQCNPLYDQYCKDHFSDG 1543

Query: 672  HCINSEGSFRCD 683
            HC     S  C+
Sbjct: 1544 HCDQGCNSAECE 1555


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score =  472 bits (1215), Expect = e-132
 Identities = 288/891 (32%), Positives = 411/891 (46%), Gaps = 128/891 (14%)

Query: 1894 NECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECER--HPCGNGTCKNT 1951
            NEC   P++C  G C++L   Y CIC+ G++ S+ Q  C+D+DEC +  H C  G C+NT
Sbjct: 876  NECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENT 935

Query: 1952 VGSYNCLCYPGFELTHNN-DCLDIDECSSFFGQVCRNGRCFNEIGSFKC-LCNEGYELTP 2009
             GS+ C+C  GF  +    +C+D+DEC      VC  G C N +G+F+C  C+ GY +T 
Sbjct: 936  EGSFLCICPAGFMASEEGTNCIDVDECLR--PDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 993

Query: 2010 DGKNCIDTNECVALPGSCSPGTCQNLEGSFRCI-CPPGYEVKSENCIDINECDEDPNICL 2068
             G+ C D +EC+  P +C    C N  GS++C+ C  G+   +  C+D++EC E PN+C 
Sbjct: 994  RGR-CEDIDECLN-PSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLE-PNVCA 1050

Query: 2069 FGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCC 2128
             G C+N  G + C C  G+  + + + C D  +        NG+C               
Sbjct: 1051 NGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQC--------------- 1095

Query: 2129 SKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCI 2188
                            K+ E +F+  C  G+  + +  D  ED++EC +   +C++GQC 
Sbjct: 1096 ----------------KNTEGSFRCTCGQGY-QLSAAKDQCEDIDEC-QHRHLCAHGQCR 1137

Query: 2189 NTDGSFRCECPMGYNLDYTGVRCVDTDEC-SIGNPCGNGTCTNVIGSFECNCNEGFEPGP 2247
            NT+GSF+C C  GY     G  C D +EC    + C  G C N  GS++C C +GF+   
Sbjct: 1138 NTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDD 1197

Query: 2248 MMNCEDINECAQNPLLCAFR--CMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDC 2305
               C+DINEC ++P LC  +  C+NT GS+ C C  G+++  D + C+D+DEC      C
Sbjct: 1198 NKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTV-C 1255

Query: 2306 ESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCEC 2365
            +S G  C N  G+F C+C  G     DG+GCVD NEC    G+C    C N+ GS+ C C
Sbjct: 1256 DSHGF-CDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVC 1314

Query: 2366 NEGFQSSSSGT-ECLDNRQGLCFAEVLQTICQMASSSRNL-------------VTKSECC 2411
             +  Q  S  T +C          +V Q   +      NL             VTK ECC
Sbjct: 1315 ADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECC 1374

Query: 2412 CDGGRGWGHQCEL--CPLPGTAQYKKICPHGPGYTTDG-----------RDIDECKVM-P 2457
            C  G GWG  CE+  CP+ GTA++ ++CP G G+   G           +D DEC +   
Sbjct: 1375 CTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQ 1434

Query: 2458 NLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPC-NYICKNTEGSYQCS 2516
             +C NG C+NT   + C+CK G   D     C D+DEC Q P  C +  C NTEGSY C 
Sbjct: 1435 EICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDEC-QDPSSCIDGQCVNTEGSYNCF 1493

Query: 2517 CPRGYVLQEDGKTC-------KDLDECQTKQHNC------QFLCVNTLGGFTCKCPPGFT 2563
            C    VL    K C       + ++E    Q  C      +++C   L G         T
Sbjct: 1494 CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQT------T 1547

Query: 2564 QHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHR 2623
                 C+     G Q +LC  K          S +  +  ++  TG             R
Sbjct: 1548 YTECCCLYGEAWGMQCALCPLKD---------SDDYAQLCNIPVTG------------RR 1586

Query: 2624 CQHGCQNILGGYRCGCPQG---YIQHYQWNQC--VDENECSNPNACGSASCYNTLGSYKC 2678
              +G   ++       P+    +IQ    N    +   EC   N C +  C      Y C
Sbjct: 1587 QPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTC 1646

Query: 2679 ACPSGFSFDQFSSACHDVNECSSSKNPC----NYGCSNTEGGYLCGCPPGY 2725
             C  G+  D     C DVNEC    N      N  C NT+G Y C C PGY
Sbjct: 1647 DCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGY 1697



 Score =  467 bits (1202), Expect = e-131
 Identities = 283/864 (32%), Positives = 409/864 (47%), Gaps = 144/864 (16%)

Query: 1158 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCV 1217
            +I+EC  NP +C  G C+N    + C C  G+  S  +  CVDI+EC+   +LC  G+C 
Sbjct: 874  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 933

Query: 1218 NMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECS-CSEGYALMP 1276
            N  G++ C C  G+ A+ +   C D+DEC+  +   +  C N+ G++ C  C  GY +  
Sbjct: 934  NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 993

Query: 1277 DGRSCADIDECENNPDICDGGQCTNIPGEYRCL-CYDGFMASMDMKTCIDVNECDLNSNI 1335
             GR C DIDEC  NP  C   QC N PG Y+C+ C +GF        C+DV+EC L  N+
Sbjct: 994  RGR-CEDIDEC-LNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ--CLDVDEC-LEPNV 1048

Query: 1336 CMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSC 1395
            C  G+C N +GS++C C  GY+       C D+DEC+ G  N  ++  C N  GSF+C+C
Sbjct: 1049 CANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQG--NLCVNGQCKNTEGSFRCTC 1106

Query: 1396 REGWIGNGIK--CIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF--TGDGFTCSDVD 1451
             +G+  +  K  C D+DEC +  H C+ + QC NT GS++C C +G+  +G G  C D++
Sbjct: 1107 GQGYQLSAAKDQCEDIDECQH-RHLCA-HGQCRNTEGSFQCVCDQGYRASGLGDHCEDIN 1164

Query: 1452 ECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNIC-VFGTCNNLP 1510
            EC E+ ++C+ G C+N  G+Y C C  GF    D+++CQDI+EC    +C   G C N  
Sbjct: 1165 ECLEDKSVCQRGDCINTAGSYDCTCPDGF-QLDDNKTCQDINECEHPGLCGPQGECLNTE 1223

Query: 1511 GMFHCICDDGYELDRTGGNCTDIDECADPINC-VNGLCVNTPGRYECNCPPDFQLNPTGV 1569
            G FHC+C  G+ +   G  C DIDEC +   C  +G C NT G + C C   FQ    G 
Sbjct: 1224 GSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQ 1283

Query: 1570 GCVDNRVGNCYLKFGPRG-------DGSLSC--------------------NTEIGV--- 1599
            GCVD  V  C L  G  G       +GS  C                    +T++ V   
Sbjct: 1284 GCVD--VNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVD 1341

Query: 1600 -------------------------GVSRSSCCCSLGKAWGNPCE--TCPPVNSTEYYTL 1632
                                      V++  CCC+ G  WG+ CE   CP + + E+  +
Sbjct: 1342 QPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEM 1401

Query: 1633 CPGGEGFRPNPITII------LEDIDEC----QELPGLCQGGNCINTFGSFQCECPQGYY 1682
            CP G+GF P   +         +D DEC    QE   +C+ G C+NT   ++C C QG Y
Sbjct: 1402 CPKGKGFVPAGESSSEAGGENYKDADECLLFGQE---ICKNGFCLNTRPGYECYCKQGTY 1458

Query: 1683 LSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCM--------- 1733
                   C D+DEC   P  C  G C NT G+Y C C    +       C+         
Sbjct: 1459 YDPVKLQCFDMDEC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQI 1517

Query: 1734 ---DMRKSFCYRSYNGT-TCENEL-PFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFK 1788
               D+ +  C+   +    C   L     T   CCC Y  G+AW   C  CP   + D+ 
Sbjct: 1518 EETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLY--GEAWGMQCALCPLKDSDDYA 1575

Query: 1789 TICGNI--------------------------PGFTFD--IHTGKAVDIDECKEIPGICA 1820
             +C NI                          P F  D  +++ + +  +EC  + G C 
Sbjct: 1576 QLC-NIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNG-CE 1633

Query: 1821 NGVCINQIGSFRCECPTGFSYNDLLLVCEDIDEC---SNGDNLCQRNADCINSPGSYRCE 1877
            NG C+     + C+C  G+  +   + C D++EC   +N  +LC +NA CIN+ GSY+C 
Sbjct: 1634 NGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLC-KNAKCINTDGSYKCL 1692

Query: 1878 CAAGFKLS--PNGACVDRNECLEI 1899
            C  G+  S  PN  C   N  L +
Sbjct: 1693 CLPGYVPSDKPN-YCTPLNTALNL 1715



 Score =  456 bits (1172), Expect = e-127
 Identities = 294/856 (34%), Positives = 394/856 (46%), Gaps = 99/856 (11%)

Query: 1283 DIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECE 1342
            +I+EC  NPDIC  G C N+P  Y C+CY+G+  S   + C+D++EC    ++C  G CE
Sbjct: 874  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 933

Query: 1343 NTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCS-CREGW-I 1400
            NT+GSF+C C  G+   +  T C DVDEC +    C     C+N  G+F+C  C  G+ +
Sbjct: 934  NTEGSFLCICPAGFMASEEGTNCIDVDEC-LRPDVCG-EGHCVNTVGAFRCEYCDSGYRM 991

Query: 1401 GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCA-CSEGFTGDGFTCSDVDECAENINL 1459
                +C D+DEC N +  C  + QCVN+PGSY+C  C+EGF G    C DVDEC E  N+
Sbjct: 992  TQRGRCEDIDECLNPS-TCP-DEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEP-NV 1048

Query: 1460 CENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDD 1519
            C NG C N+ G+Y C C  G+T   D + C+DIDEC   N+CV G C N  G F C C  
Sbjct: 1049 CANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQ 1108

Query: 1520 GYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNC 1579
            GY+L      C DIDEC     C +G C NT G ++C C   ++ +  G  C D  +  C
Sbjct: 1109 GYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCED--INEC 1166

Query: 1580 Y--LKFGPRGD-----GSLSCNTEIGVGVSRSSCCCSLGKAWGNPCE---TCPPVN---S 1626
                    RGD     GS  C    G  +  +  C  +     N CE    C P     +
Sbjct: 1167 LEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDI-----NECEHPGLCGPQGECLN 1221

Query: 1627 TEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSED 1686
            TE    C   +GF  +      EDIDEC         G C NT GSF+C C QG+   +D
Sbjct: 1222 TEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQD 1281

Query: 1687 TRICEDIDECFAHPGVCGPGTCYNTLGNYTCICP---PEYMQVNG---GHNCMDM----- 1735
             + C D++EC    GVCG   C N  G++ C+C     EY  + G        D+     
Sbjct: 1282 GQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVD 1341

Query: 1736 ----RKSFCYRSYN-GTTCENELPFNVTKRMCCCTYNVGKAWNKPCE--PCPTPGTADFK 1788
                 K  CY + N  + C+N L  NVTK+ CCCT   G  W   CE  PCP  GTA+F 
Sbjct: 1342 QPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAG--WGDNCEIFPCPVLGTAEFT 1399

Query: 1789 TIC----GNIPGFTFDIHTG--KAVDIDECKEI-PGICANGVCINQIGSFRCECPTGFSY 1841
             +C    G +P        G     D DEC      IC NG C+N    + C C  G  Y
Sbjct: 1400 EMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYY 1459

Query: 1842 NDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKL-SPNGACV---DRNECL 1897
            + + L C D+DEC +  +    +  C+N+ GSY C C     L +    C+   + NE +
Sbjct: 1460 DPVKLQCFDMDECQDPSSCI--DGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQI 1517

Query: 1898 EIPN--------------VCSHGLCVDLQGSY-QCICHNGFKASQDQTMC--MDVDEC-- 1938
            E  +              VCS  L V  Q +Y +C C  G        +C   D D+   
Sbjct: 1518 EETDVYQDLCWEHLSDEYVCSRPL-VGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQ 1576

Query: 1939 --------ERHPCGNGTCKNTVGSYNCLCYPGF---ELTHNNDCLDIDECSSFFGQVCRN 1987
                     R P G     +    Y     P F      ++ + L  +EC    G  C N
Sbjct: 1577 LCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNG--CEN 1634

Query: 1988 GRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGS---CSPGTCQNLEGSFRCICP 2044
            GRC      + C C +GY L      C+D NEC  L      C    C N +GS++C+C 
Sbjct: 1635 GRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCL 1694

Query: 2045 PGY--EVKSENCIDIN 2058
            PGY    K   C  +N
Sbjct: 1695 PGYVPSDKPNYCTPLN 1710



 Score =  416 bits (1069), Expect = e-115
 Identities = 279/877 (31%), Positives = 392/877 (44%), Gaps = 124/877 (14%)

Query: 535  DVDECTSNP--CTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCV 592
            +++ECT NP  C  G C+N P  Y C C+ G++ +  ++ C+DIDEC Q   LC  GRC 
Sbjct: 874  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 933

Query: 593  NTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKC-ICKPGFVLAP 651
            NT+GSF CIC AGF  + +G NC+D DEC   ++C  G C+N  G+F+C  C  G+ +  
Sbjct: 934  NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 993

Query: 652  NGRYCTDVDECQTPGICMNGHCINSEGSFRC-DCPPGLAVGMDGRVCVDTHMRSTCYGGI 710
             GR C D+DEC  P  C +  C+NS GS++C  C  G   G +G+ C+D      C   +
Sbjct: 994  RGR-CEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFR-GWNGQ-CLDV---DEC---L 1044

Query: 711  KKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDG---- 766
            +  VC       +  S  C  +  Y      + C   +  +   LC +G     +G    
Sbjct: 1045 EPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRC 1104

Query: 767  ---------------RDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDI 811
                            DI+EC     +CA+G C N  GS++C C+ GY     G +C DI
Sbjct: 1105 TCGQGYQLSAAKDQCEDIDECQ-HRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDI 1163

Query: 812  DECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCV---NGACRN 868
            +ECL ++ +C  G C NT GSY CTCP G+    + +TC+DINECE +P +    G C N
Sbjct: 1164 NECLEDKSVCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDINECE-HPGLCGPQGECLN 1221

Query: 869  NLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAW 928
              GSF+C C  G  +S+ G  C D              C VN         C  T G+  
Sbjct: 1222 TEGSFHCVCQQGFSISADGRTCEDI-----------DEC-VNNTVCDSHGFCDNTAGSF- 1268

Query: 929  GSPCERCELDTACPRGL-ARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPE--- 984
                 RC     C +G  A   G  C DVNECE+  GVC    C N +GSF C C +   
Sbjct: 1269 -----RC----LCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQ 1319

Query: 985  ---GLTLDGTGRVCLDIRME---------QCYLKW-DEDECIHPVPGKFRMDACCCAVGA 1031
                +T     R   D+ ++         +CY    D   C + +        CCC  GA
Sbjct: 1320 EYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGA 1379

Query: 1032 AWGTECE--ECPKPGTKEYETLCPRGAGFANRGDVLT--GRPFYKDINECKAF-PGMCTY 1086
             WG  CE   CP  GT E+  +CP+G GF   G+  +  G   YKD +EC  F   +C  
Sbjct: 1380 GWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKN 1439

Query: 1087 GKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGY 1146
            G C NT   ++C C  G   D  +  C D+DEC+  P  C  G CVNT GS+ C C    
Sbjct: 1440 GFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQ-DPSSCIDGQCVNTEGSYNCFCTHPM 1498

Query: 1147 ESGFMMMKNCM-------DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCV 1199
                   K C+        I+E +    LC      +    + C  PL  + +   E C 
Sbjct: 1499 VLD-ASEKRCIRPAESNEQIEETDVYQDLC----WEHLSDEYVCSRPLVGKQTTYTECCC 1553

Query: 1200 DINE--------CSLSDN-----LCR-----------NGKCVNMIGTYQCSCNPGYQATP 1235
               E        C L D+     LC                V+    Y    +P +    
Sbjct: 1554 LYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDR 1613

Query: 1236 DRQGCTDI--DECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECE---NN 1290
                  ++  +EC I+NG  + +C   +  Y C C +GY L     +C D++EC+   N 
Sbjct: 1614 FLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNR 1673

Query: 1291 PDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVN 1327
              +C   +C N  G Y+CLC  G++ S     C  +N
Sbjct: 1674 MSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710



 Score =  414 bits (1064), Expect = e-115
 Identities = 299/942 (31%), Positives = 406/942 (43%), Gaps = 170/942 (18%)

Query: 852  DINECESNP--CVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNI-QDSRCE 908
            +INEC  NP  C  G C N    + C C  G + S     C+D  + T   ++    RCE
Sbjct: 874  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 933

Query: 909  VNINGATLKSECCATLGAAWGSPCERCELDTACPRG-LARIKGVTCEDVNECEVFPGVCP 967
             N  G+ L                        CP G +A  +G  C DV+EC + P VC 
Sbjct: 934  -NTEGSFL----------------------CICPAGFMASEEGTNCIDVDEC-LRPDVCG 969

Query: 968  NGRCVNSKGSFHCE-CPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACC 1026
             G CVN+ G+F CE C  G  +   GR C DI           DEC++P       D  C
Sbjct: 970  EGHCVNTVGAFRCEYCDSGYRMTQRGR-CEDI-----------DECLNPSTCP---DEQC 1014

Query: 1027 CAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTY 1086
              V +    +C  C + G + +   C                    D++EC   P +C  
Sbjct: 1015 --VNSPGSYQCVPCTE-GFRGWNGQC-------------------LDVDECLE-PNVCAN 1051

Query: 1087 GKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGY 1146
            G C N  GS+ C C+ G+    + ++C DIDEC+   +LC +G C NT GSF C C +GY
Sbjct: 1052 GDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQ-QGNLCVNGQCKNTEGSFRCTCGQGY 1110

Query: 1147 ESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSL 1206
            +        C DIDEC+   L C  G C NTEGSFQC C  G+  S   + C DINEC  
Sbjct: 1111 QLS-AAKDQCEDIDECQHRHL-CAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLE 1168

Query: 1207 SDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQ--CTNSEGSY 1264
              ++C+ G C+N  G+Y C+C  G+Q   D + C DI+EC    G C  Q  C N+EGS+
Sbjct: 1169 DKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINECE-HPGLCGPQGECLNTEGSF 1226

Query: 1265 ECSCSEGYALMPDGRSCADIDECENNPDICDG-GQCTNIPGEYRCLCYDGFMASMDMKTC 1323
             C C +G+++  DGR+C DIDEC NN  +CD  G C N  G +RCLCY GF A  D + C
Sbjct: 1227 HCVCQQGFSISADGRTCEDIDECVNN-TVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGC 1285

Query: 1324 IDVNECDLNSNICMFGECENTKGSFICHC---QLGYSVKKG-----TTGCTDVD------ 1369
            +DVNEC+L S +C    CEN +GSF+C C      YS   G     T+   DVD      
Sbjct: 1286 VDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKE 1345

Query: 1370 ECEIGAHNCDMHASCLNI--PGSFK--CSCREGWIGNGIKCIDLDECSNGTHQCSINAQC 1425
            E +   +N +  + C N+  P   K  C C  G  G G  C        GT        C
Sbjct: 1346 EKKECYYNLNDASLCDNVLAPNVTKQECCCTSG-AGWGDNCEIFPCPVLGT--AEFTEMC 1402

Query: 1426 VNTPGSYRCACSEGFTGDGFTCSDVDEC-AENINLCENGQCLNVPGAYRCECEMGFTPAS 1484
                G      S    G G    D DEC      +C+NG CLN    Y C C+ G     
Sbjct: 1403 PKGKGFVPAGESSSEAG-GENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDP 1461

Query: 1485 DSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNC---TDIDECADPIN 1541
                C D+DEC   + C+ G C N  G ++C C     LD +   C    + +E  +  +
Sbjct: 1462 VKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETD 1521

Query: 1542 CVNGLC-VNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVG 1600
                LC  +    Y C+ P                                     +G  
Sbjct: 1522 VYQDLCWEHLSDEYVCSRP------------------------------------LVGKQ 1545

Query: 1601 VSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLC---------PGG--------EGFRPNP 1643
             + + CCC  G+AWG  C  CP  +S +Y  LC         P G        E + P  
Sbjct: 1546 TTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEA 1605

Query: 1644 ITIILED----------IDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDI 1693
                ++D           +EC  L G C+ G C+     + C+C  GY+L      C D+
Sbjct: 1606 DPYFIQDRFLNSFEELQAEECGILNG-CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDV 1664

Query: 1694 DECFA---HPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNC 1732
            +EC        +C    C NT G+Y C+C P Y+  +  + C
Sbjct: 1665 NECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYC 1706



 Score =  414 bits (1064), Expect = e-115
 Identities = 283/852 (33%), Positives = 384/852 (45%), Gaps = 158/852 (18%)

Query: 1796 GFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECS 1855
            G+ F     K VDIDEC ++  +C+ G C N  GSF C CP GF  ++    C D+DEC 
Sbjct: 904  GYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECL 963

Query: 1856 NGDNLCQRNADCINSPGSYRCE-CAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGS 1914
              D +C     C+N+ G++RCE C +G++++  G C D +ECL  P+ C    CV+  GS
Sbjct: 964  RPD-VCGEG-HCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLN-PSTCPDEQCVNSPGS 1020

Query: 1915 YQCI-CHNGFKASQDQTMCMDVDEC-ERHPCGNGTCKNTVGSYNCLCYPGFELTHNND-C 1971
            YQC+ C  GF+    Q  C+DVDEC E + C NG C N  GSY C C+ G+  T ++  C
Sbjct: 1021 YQCVPCTEGFRGWNGQ--CLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHC 1078

Query: 1972 LDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGT 2031
             DIDEC    G +C NG+C N  GSF+C C +GY+L+     C D +EC      C+ G 
Sbjct: 1079 RDIDECQQ--GNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRH-LCAHGQ 1135

Query: 2032 CQNLEGSFRCICPPGYEVKS--ENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVL 2089
            C+N EGSF+C+C  GY      ++C DINEC ED ++C  G C NT G + C CP GF L
Sbjct: 1136 CRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL 1195

Query: 2090 SDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEV 2149
             DN + C D  +           C  P                  G   P   C  + E 
Sbjct: 1196 DDN-KTCQDINE-----------CEHP------------------GLCGPQGEC-LNTEG 1224

Query: 2150 AFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGV 2209
            +F  +C  G  ++ +   T ED++EC+ +    S+G C NT GSFRC C  G+     G 
Sbjct: 1225 SFHCVCQQGF-SISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQ 1283

Query: 2210 RCVDTDECSI-GNPCGNGTCTNVIGSFECNC-NEGFEPGPMMN-C--------------- 2251
             CVD +EC +    CG   C NV GSF C C +E  E  PM   C               
Sbjct: 1284 GCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQP 1343

Query: 2252 -EDINECAQNPLLCAFRCMNTFG----SYECTCPIG--------------YALREDQKMC 2292
             E+  EC  N L  A  C N         EC C  G                  E  +MC
Sbjct: 1344 KEEKKECYYN-LNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMC 1402

Query: 2293 ---------------------KDLDECAE-GLHDCESRGMMCKNLIGTFMCICPPGMARR 2330
                                 KD DEC   G   C++    C N    + C C  G    
Sbjct: 1403 PKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNG--FCLNTRPGYECYCKQGTYYD 1460

Query: 2331 PDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECL---DNRQGLCF 2387
            P    C D +EC+  P  C +G+CVN  GSY C C       +S   C+   ++ + +  
Sbjct: 1461 PVKLQCFDMDECQD-PSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEE 1519

Query: 2388 AEVLQTICQMASS-----SRNLVTK----SECCCDGGRGWGHQCELCPLPGTAQYKKIC- 2437
             +V Q +C    S     SR LV K    +ECCC  G  WG QC LCPL  +  Y ++C 
Sbjct: 1520 TDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCN 1579

Query: 2438 --------PHGPGYTTDGRD-----------------------IDECKVMPNLCTNGQCI 2466
                    P+G     D  +                        +EC ++ N C NG+C+
Sbjct: 1580 IPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGIL-NGCENGRCV 1638

Query: 2467 NTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPC----NYICKNTEGSYQCSCPRGYV 2522
                 + C C  GY  D +  +C+D++EC +         N  C NT+GSY+C C  GYV
Sbjct: 1639 RVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYV 1698

Query: 2523 LQEDGKTCKDLD 2534
              +    C  L+
Sbjct: 1699 PSDKPNYCTPLN 1710



 Score =  392 bits (1006), Expect = e-108
 Identities = 278/918 (30%), Positives = 388/918 (42%), Gaps = 190/918 (20%)

Query: 1448 SDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECS-FQNICVFGTC 1506
            ++++EC  N ++C  G C+N+P  Y C C  G+  +   R C DIDEC+  Q++C  G C
Sbjct: 873  TEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRC 932

Query: 1507 NNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECN-CPPDFQLN 1565
             N  G F CIC  G+     G NC D+DEC  P  C  G CVNT G + C  C   +++ 
Sbjct: 933  ENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMT 992

Query: 1566 PTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN 1625
              G  C D  +  C                     ++ S+C          P E C  VN
Sbjct: 993  QRG-RCED--IDEC---------------------LNPSTC----------PDEQC--VN 1016

Query: 1626 STEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSE 1685
            S   Y   P  EGFR      +  D+DEC E P +C  G+C N  GS+ C C +GY  + 
Sbjct: 1017 SPGSYQCVPCTEGFRGWNGQCL--DVDECLE-PNVCANGDCSNLEGSYMCSCHKGYTRTP 1073

Query: 1686 DTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYN 1745
            D + C DIDEC     +C  G C NT G++ C C   Y        C D+ +        
Sbjct: 1074 DHKHCRDIDEC-QQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDE-------- 1124

Query: 1746 GTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGK 1805
               C++       + +C      G+  N       T G+  F+ +C    G+        
Sbjct: 1125 ---CQH-------RHLCAH----GQCRN-------TEGS--FQCVCDQ--GYRASGLGDH 1159

Query: 1806 AVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNA 1865
              DI+EC E   +C  G CIN  GS+ C CP GF  +D    C+DI+EC +   LC    
Sbjct: 1160 CEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNK-TCQDINECEH-PGLCGPQG 1217

Query: 1866 DCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFK 1924
            +C+N+ GS+ C C  GF +S +G  C D +EC+      SHG C +  GS++C+C+ GF+
Sbjct: 1218 ECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 1277

Query: 1925 ASQDQTMCMDVDECE--RHPCGNGTCKNTVGSYNCLC---------YPGFELTHNNDCLD 1973
            A QD   C+DV+ECE     CG   C+N  GS+ C+C           G   +  +  LD
Sbjct: 1278 APQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLD 1337

Query: 1974 ID---------ECSSFFGQ--VCRNGRCFNEIGSFKCLCNEGY----------------- 2005
            +D         EC        +C N    N +   +C C  G                  
Sbjct: 1338 VDVDQPKEEKKECYYNLNDASLCDNVLAPN-VTKQECCCTSGAGWGDNCEIFPCPVLGTA 1396

Query: 2006 ---ELTPDGKNCI---------------DTNECVALPGS-CSPGTCQNLEGSFRCICPPG 2046
               E+ P GK  +               D +EC+      C  G C N    + C C  G
Sbjct: 1397 EFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQG 1456

Query: 2047 --YEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCF------- 2097
              Y+     C D++EC +DP+ C+ G C NT G + C C    VL  + +RC        
Sbjct: 1457 TYYDPVKLQCFDMDEC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNE 1515

Query: 2098 -----DTRQSFCFTNFENGK-CSVPKAFN-TTKAKCCCSKMPGEGWGDPCELCPKDDEVA 2150
                 D  Q  C+ +  +   CS P     TT  +CCC  + GE WG  C LCP  D   
Sbjct: 1516 QIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCC--LYGEAWGMQCALCPLKDSDD 1573

Query: 2151 FQDLC---------PYGHGTVPSLHD--TRE-----------------DVNECLESPGIC 2182
            +  LC         PYG   +    +  T E                    EC    G C
Sbjct: 1574 YAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNG-C 1632

Query: 2183 SNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNP----CGNGTCTNVIGSFECN 2238
             NG+C+     + C+C  GY+LD   + CVD +EC   N     C N  C N  GS++C 
Sbjct: 1633 ENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCL 1692

Query: 2239 CNEGFEPGPMMN-CEDIN 2255
            C  G+ P    N C  +N
Sbjct: 1693 CLPGYVPSDKPNYCTPLN 1710



 Score =  371 bits (952), Expect = e-102
 Identities = 261/851 (30%), Positives = 363/851 (42%), Gaps = 183/851 (21%)

Query: 2016 DTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPNICLFGSCT 2073
            + NEC   P  C  G C NL   + CIC  GY    +   C+DI+EC +  ++C  G C 
Sbjct: 874  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 933

Query: 2074 NTPGGFQCLCPPGFVLSDNGRRCFDT---------------------RQSFCFTNF---E 2109
            NT G F C+CP GF+ S+ G  C D                      R  +C + +   +
Sbjct: 934  NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 993

Query: 2110 NGKC-SVPKAFN-TTKAKCCCSKMPG-----------EGWGDPC---------ELCPKDD 2147
             G+C  + +  N +T     C   PG            GW   C          +C   D
Sbjct: 994  RGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGD 1053

Query: 2148 ----EVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYN 2203
                E ++   C  G+   P  H    D++EC +   +C NGQC NT+GSFRC C  GY 
Sbjct: 1054 CSNLEGSYMCSCHKGYTRTPD-HKHCRDIDEC-QQGNLCVNGQCKNTEGSFRCTCGQGYQ 1111

Query: 2204 LDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFE-PGPMMNCEDINECAQNPL 2262
            L     +C D DEC   + C +G C N  GSF+C C++G+   G   +CEDINEC ++  
Sbjct: 1112 LSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKS 1171

Query: 2263 LC-AFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAE-GLHDCESRGMMCKNLIGTFM 2320
            +C    C+NT GSY+CTCP G+ L +D K C+D++EC   GL  C  +G  C N  G+F 
Sbjct: 1172 VCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDINECEHPGL--CGPQG-ECLNTEGSFH 1227

Query: 2321 CICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLD 2380
            C+C  G +   DG  C D +EC        +G C N  GS+RC C +GFQ+   G  C+D
Sbjct: 1228 CVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVD 1287

Query: 2381 NRQ-----GLC---FAEVLQ----TICQMASSSRNLVT---------------------K 2407
              +     G+C   F E ++     +C   +   + +T                     K
Sbjct: 1288 VNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEK 1347

Query: 2408 SEC-----------------------CCDGGRGWGHQCEL--CPLPGTAQYKKICPHGPG 2442
             EC                       CC  G GWG  CE+  CP+ GTA++ ++CP G G
Sbjct: 1348 KECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKG 1407

Query: 2443 YTTDG-----------RDIDECKVM-PNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCI 2490
            +   G           +D DEC +    +C NG C+NT   + C+CK G   D     C 
Sbjct: 1408 FVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCF 1467

Query: 2491 DLDECSQSPKPC-NYICKNTEGSYQCSCPRGYVLQEDGKTC-------KDLDECQTKQHN 2542
            D+DEC Q P  C +  C NTEGSY C C    VL    K C       + ++E    Q  
Sbjct: 1468 DMDEC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDL 1526

Query: 2543 C------QFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKG------ICQN 2590
            C      +++C   L G         T     C+     G Q +LC  K       +C N
Sbjct: 1527 CWEHLSDEYVCSRPLVG------KQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLC-N 1579

Query: 2591 TP-----------------GSFSCECQRGFSLDATGLNCEDV--DECDGNHRCQHG-CQN 2630
             P                   ++ E    F  D    + E++  +EC   + C++G C  
Sbjct: 1580 IPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVR 1639

Query: 2631 ILGGYRCGCPQGYIQHYQWNQCVDENECSNPN----ACGSASCYNTLGSYKCACPSGFSF 2686
            +  GY C C  GY        CVD NEC   N     C +A C NT GSYKC C  G+  
Sbjct: 1640 VQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVP 1699

Query: 2687 DQFSSACHDVN 2697
                + C  +N
Sbjct: 1700 SDKPNYCTPLN 1710



 Score =  364 bits (935), Expect = e-100
 Identities = 253/793 (31%), Positives = 350/793 (44%), Gaps = 153/793 (19%)

Query: 495  IDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANG-DCIDVDEC-TSNPCTNGDCVNT 552
            ID C    +LC  GRC  T  S+ C C  G+     G +CIDVDEC   + C  G CVNT
Sbjct: 917  IDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNT 976

Query: 553  PGSYYCK-CHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCI-CNAGFELTT 610
             G++ C+ C +G++ T  +  C DIDEC+ N   C + +CVN+ GS+QC+ C  GF    
Sbjct: 977  VGAFRCEYCDSGYRMT-QRGRCEDIDECL-NPSTCPDEQCVNSPGSYQCVPCTEGFR--- 1031

Query: 611  DGKN--CVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGIC 668
             G N  C+D DEC   N+C NG C N +GS+ C C  G+   P+ ++C D+DECQ   +C
Sbjct: 1032 -GWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLC 1090

Query: 669  MNGHCINSEGSFRCDCPPGLAVGMDGRVCVD----THMRSTCYG------GIKKGVCVRP 718
            +NG C N+EGSFRC C  G  +      C D     H     +G      G  + VC + 
Sbjct: 1091 VNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQG 1150

Query: 719  FPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDG----RDINECAL 774
            +  +     C   N        CQ     N+A  +  C+   G  +D     +DINEC  
Sbjct: 1151 YRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYD-CTCPDGFQLDDNKTCQDINECE- 1208

Query: 775  DPDICA-NGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCD-NGLCRNTPGS 832
             P +C   G C N  GS+ C C  G+   A GR C DIDEC VN  +CD +G C NT GS
Sbjct: 1209 HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGS 1267

Query: 833  YSCTCPPGYVFRTETETCEDINECE--SNPCVNGACRNNLGSFNCECSPGSK-------- 882
            + C C  G+    + + C D+NECE  S  C    C N  GSF C C+  ++        
Sbjct: 1268 FRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQ 1327

Query: 883  ---LSSTGL-ICID---SLKGTCWLNIQD-SRCEVNINGATLKSECCATLGAAWGSPCE- 933
                +ST L + +D     K  C+ N+ D S C+  +     K ECC T GA WG  CE 
Sbjct: 1328 CRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEI 1387

Query: 934  -------RCELDTACPRGLARIK---------GVTCEDVNECEVF--------------- 962
                     E    CP+G   +          G   +D +EC +F               
Sbjct: 1388 FPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRP 1447

Query: 963  ---------------------------PGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVC 995
                                       P  C +G+CVN++GS++C C   + LD + + C
Sbjct: 1448 GYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRC 1507

Query: 996  L------------DIRMEQCYLKW-DEDECIHPVPGK-FRMDACCCAVGAAWGTECEECP 1041
            +            D+  + C+    DE  C  P+ GK      CCC  G AWG +C  CP
Sbjct: 1508 IRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCP 1567

Query: 1042 KPGTKEYETLC---------PRG----AGFANRGDVLTGRPFYKD----------INECK 1078
               + +Y  LC         P G      F+ +        F +D            EC 
Sbjct: 1568 LKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECG 1627

Query: 1079 AFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDEC-----RISPDLCGSGICVN 1133
               G C  G+C      + C C  G+ LD  +  C D++EC     R+S  LC +  C+N
Sbjct: 1628 ILNG-CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMS--LCKNAKCIN 1684

Query: 1134 TPGSFECECFEGY 1146
            T GS++C C  GY
Sbjct: 1685 TDGSYKCLCLPGY 1697



 Score =  363 bits (933), Expect = 1e-99
 Identities = 252/812 (31%), Positives = 364/812 (44%), Gaps = 113/812 (13%)

Query: 503  NLCLNGRCIPTVSSYRCE-CNMGYKQDANGDCIDVDECTS-NPCTNGDCVNTPGSYYC-K 559
            ++C  G C+ TV ++RCE C+ GY+    G C D+DEC + + C +  CVN+PGSY C  
Sbjct: 966  DVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVP 1025

Query: 560  CHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHD 619
            C  GF+    +  C+D+DEC++  V C NG C N +GS+ C C+ G+  T D K+C D D
Sbjct: 1026 CTEGFRGWNGQ--CLDVDECLEPNV-CANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDID 1082

Query: 620  ECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGS 679
            EC   N+C+NG C N +GSF+C C  G+ L+     C D+DECQ   +C +G C N+EGS
Sbjct: 1083 ECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGS 1142

Query: 680  FRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGE 739
            F+C C  G      G  C D +         ++G C+       T     C  PD GF  
Sbjct: 1143 FQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCIN------TAGSYDCTCPD-GF-- 1193

Query: 740  PCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICA-NGICENLRGSYRCNCNSG 798
                       + +  C          +DINEC   P +C   G C N  GS+ C C  G
Sbjct: 1194 ---------QLDDNKTC----------QDINECE-HPGLCGPQGECLNTEGSFHCVCQQG 1233

Query: 799  YEPDASGRNCIDIDECLVNRLLCDN-GLCRNTPGSYSCTCPPGYVFRTETETCEDINECE 857
            +   A GR C DIDEC VN  +CD+ G C NT GS+ C C  G+    + + C D+NECE
Sbjct: 1234 FSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECE 1292

Query: 858  --SNPCVNGACRNNLGSFNCECSPGSK-----------LSSTGL-ICIDSLKGT---CWL 900
              S  C    C N  GSF C C+  ++            +ST L + +D  K     C+ 
Sbjct: 1293 LLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYY 1352

Query: 901  NIQD-SRCEVNINGATLKSECCATLGAAWGSPCE--------RCELDTACPRGLARIK-- 949
            N+ D S C+  +     K ECC T GA WG  CE          E    CP+G   +   
Sbjct: 1353 NLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAG 1412

Query: 950  -------GVTCEDVNECEVF-PGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRME 1001
                   G   +D +EC +F   +C NG C+N++  + C C +G   D     C D  M+
Sbjct: 1413 ESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFD--MD 1470

Query: 1002 QCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANR 1061
            +C    D   CI         D  C     ++   C         E   + P     A  
Sbjct: 1471 ECQ---DPSSCI---------DGQCVNTEGSYNCFCTHPMVLDASEKRCIRP-----AES 1513

Query: 1062 GDVLTGRPFYKDIN-ECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCT--DIDE 1118
             + +     Y+D+  E  +   +C+           +C C  G A  M+   C   D D+
Sbjct: 1514 NEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDD 1573

Query: 1119 ----CRISP----DLCGSGICVNTPGSFECECFEGY-ESGFMMMKNCMDIDECERNPLL- 1168
                C I         G    V+    +  E    + +  F+     +  +EC    +L 
Sbjct: 1574 YAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECG---ILN 1630

Query: 1169 -CRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDN---LCRNGKCVNMIGTYQ 1224
             C  G CV  +  + CDC  G+ L  ++  CVD+NEC   +N   LC+N KC+N  G+Y+
Sbjct: 1631 GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYK 1690

Query: 1225 CSCNPGYQATPDRQGCTDIDECMIMNGGCDTQ 1256
            C C PGY  +     CT ++  + +    D +
Sbjct: 1691 CLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE 1722



 Score =  362 bits (930), Expect = 2e-99
 Identities = 249/824 (30%), Positives = 346/824 (41%), Gaps = 134/824 (16%)

Query: 276  DVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECS 335
            +++EC   P IC  G+CIN    + C C  G++ SE  +KC DIDEC+ +  +C  G C 
Sbjct: 874  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 933

Query: 336  NTVGSYFCVCPRGYVTSTDGSRCIDQRT---------GMCFSGLVNGRCAQELPG-RMTK 385
            NT GS+ C+CP G++ S +G+ CID            G C + +   RC     G RMT+
Sbjct: 934  NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 993

Query: 386  MQCCCEPGRCWGIGTIPEACPVRGSEEYRRL-CMDGLP--MGGIPGSAGSRPGGTGGNGF 442
               C +   C    T P+   V     Y+ + C +G     G               NG 
Sbjct: 994  RGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGD 1053

Query: 443  APSGNGNGYGPGGTGFIPIPGG----------------NGFSPGVGGAGVGAGGQGPIIT 486
              +  G+       G+   P                  NG      G+     GQG  ++
Sbjct: 1054 CSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLS 1113

Query: 487  GLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGD-CIDVDECTSNP-- 543
                  + ID C+H  +LC +G+C  T  S++C C+ GY+    GD C D++EC  +   
Sbjct: 1114 AAKDQCEDIDECQHR-HLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSV 1172

Query: 544  CTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICN 603
            C  GDC+NT GSY C C  GFQ    K  C DI+EC   G+    G C+NT+GSF C+C 
Sbjct: 1173 CQRGDCINTAGSYDCTCPDGFQLDDNK-TCQDINECEHPGLCGPQGECLNTEGSFHCVCQ 1231

Query: 604  AGFELTTDGKNCVDHDECTTTNMC-LNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDEC 662
             GF ++ DG+ C D DEC    +C  +G C N  GSF+C+C  GF    +G+ C DV+EC
Sbjct: 1232 QGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNEC 1291

Query: 663  Q-TPGICMNGHCINSEGSFRC--------------DCPPGLAVGMDGRVCVDTHMRSTCY 707
            +   G+C    C N EGSF C               C    +  +D  V      +  CY
Sbjct: 1292 ELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECY 1351

Query: 708  GGIK-KGVCVRPFPGAVTKSECCCANPDYGFGEPCQ--PCPAKNSAEFHGLCSSGVGITV 764
              +    +C       VTK ECCC +   G+G+ C+  PCP   +AEF  +C  G G   
Sbjct: 1352 YNLNDASLCDNVLAPNVTKQECCCTS-GAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVP 1410

Query: 765  DG-----------RDINECAL-DPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDID 812
             G           +D +EC L   +IC NG C N R  Y C C  G   D     C D+D
Sbjct: 1411 AGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMD 1470

Query: 813  ECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGS 872
            EC  +   C +G C NT GSY+C C    V     + C  I   ESN  +          
Sbjct: 1471 EC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRC--IRPAESNEQIEET------- 1520

Query: 873  FNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSR-CEVNING-ATLKSECCATLGAAWGS 930
                               D  +  CW ++ D   C   + G  T  +ECC   G AWG 
Sbjct: 1521 -------------------DVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGM 1561

Query: 931  PCERCELDTA------C---------PRGLARIKGVTCE--------------------- 954
             C  C L  +      C         P G   +   + +                     
Sbjct: 1562 QCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEEL 1621

Query: 955  DVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDI 998
               EC +  G C NGRCV  +  + C+C +G  LD     C+D+
Sbjct: 1622 QAEECGILNG-CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDV 1664



 Score =  349 bits (895), Expect = 3e-95
 Identities = 270/920 (29%), Positives = 388/920 (42%), Gaps = 146/920 (15%)

Query: 743  PCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPD 802
            P P + + E     +S V       +INEC ++PDIC  G C NL   Y C C  GY   
Sbjct: 849  PVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFS 908

Query: 803  ASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINEC-ESNPC 861
               R C+DIDEC   + LC  G C NT GS+ C CP G++   E   C D++EC   + C
Sbjct: 909  EQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVC 968

Query: 862  VNGACRNNLGSFNCE-CSPGSKLSSTGLICIDSLKGTCWLNIQDSRCE---VNINGATLK 917
              G C N +G+F CE C  G +++  G                  RCE     +N +T  
Sbjct: 969  GEGHCVNTVGAFRCEYCDSGYRMTQRG------------------RCEDIDECLNPSTCP 1010

Query: 918  SECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGS 977
             E C     ++     +C     C  G     G  C DV+EC + P VC NG C N +GS
Sbjct: 1011 DEQCVNSPGSY-----QC---VPCTEGFRGWNG-QCLDVDEC-LEPNVCANGDCSNLEGS 1060

Query: 978  FHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTEC 1037
            + C C +G T     + C DI           DEC              C  G    TE 
Sbjct: 1061 YMCSCHKGYTRTPDHKHCRDI-----------DEC---------QQGNLCVNGQCKNTE- 1099

Query: 1038 EECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFK 1097
                      +   C +G   +   D        +DI+EC+    +C +G+CRNT GSF+
Sbjct: 1100 --------GSFRCTCGQGYQLSAAKDQC------EDIDECQ-HRHLCAHGQCRNTEGSFQ 1144

Query: 1098 CRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCM 1157
            C C+ G+       +C DI+EC     +C  G C+NT GS++C C +G++      K C 
Sbjct: 1145 CVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQ--LDDNKTCQ 1202

Query: 1158 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLC-RNGKC 1216
            DI+ECE   L    G C+NTEGSF C C  G  +S     C DI+EC +++ +C  +G C
Sbjct: 1203 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFC 1261

Query: 1217 VNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGC-DTQCTNSEGSYECSC---SEGY 1272
             N  G+++C C  G+QA  D QGC D++EC +++G C +  C N EGS+ C C   ++ Y
Sbjct: 1262 DNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEY 1321

Query: 1273 ALMPD---GRSCADID-----------ECE---NNPDICDGGQCTNIPGEYRCLCYDGFM 1315
            + M      R+  D+D           EC    N+  +CD     N+  +  C C  G  
Sbjct: 1322 SPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVT-KQECCCTSG-- 1378

Query: 1316 ASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGA 1375
                     ++  C +         C   KG F+   +   S + G     D DEC +  
Sbjct: 1379 --AGWGDNCEIFPCPVLGTAEFTEMCPKGKG-FVPAGE--SSSEAGGENYKDADECLLFG 1433

Query: 1376 HNCDMHASCLNIPGSFKCSCREGWIGNGIK--CIDLDECSNGTHQCSINAQCVNTPGSYR 1433
                 +  CLN    ++C C++G   + +K  C D+DEC + +    I+ QCVNT GSY 
Sbjct: 1434 QEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPS--SCIDGQCVNTEGSYN 1491

Query: 1434 CACSEGFTGDG--------------FTCSDV--DECAENIN---LCENGQCLNVPGAYRC 1474
            C C+     D                  +DV  D C E+++   +C             C
Sbjct: 1492 CFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTEC 1551

Query: 1475 ECEMGFTPASDSRSCQDIDECSFQNIC-VFGTCNNLPGMFHCICD---------DGYEL- 1523
             C  G         C   D   +  +C +  T    P     + D         D Y + 
Sbjct: 1552 CCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQ 1611

Query: 1524 DRTGGNCTDI--DECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVD-------- 1573
            DR   +  ++  +EC     C NG CV     Y C+C   + L+   + CVD        
Sbjct: 1612 DRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELN 1671

Query: 1574 NRVGNCYLKFGPRGDGSLSC 1593
            NR+  C        DGS  C
Sbjct: 1672 NRMSLCKNAKCINTDGSYKC 1691



 Score =  320 bits (821), Expect = 1e-86
 Identities = 190/521 (36%), Positives = 244/521 (46%), Gaps = 52/521 (9%)

Query: 2253 DINECAQNPLLC-AFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMM 2311
            +INEC  NP +C A  C+N    Y C C  GY   E Q+ C D+DEC +  H C S+G  
Sbjct: 874  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLC-SQGR- 931

Query: 2312 CKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCE-CNEGFQ 2370
            C+N  G+F+CICP G     +G  C+D +EC  +P +C  G CVN +G++RCE C+ G++
Sbjct: 932  CENTEGSFLCICPAGFMASEEGTNCIDVDEC-LRPDVCGEGHCVNTVGAFRCEYCDSGYR 990

Query: 2371 SSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGT 2430
             +  G  C D  + L  +      C  +  S   V     C +G RGW  QC        
Sbjct: 991  MTQRG-RCEDIDECLNPSTCPDEQCVNSPGSYQCVP----CTEGFRGWNGQC-------- 1037

Query: 2431 AQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCI 2490
                              D+DEC + PN+C NG C N  GS+ C C  GYT       C 
Sbjct: 1038 -----------------LDVDEC-LEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCR 1079

Query: 2491 DLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNT 2550
            D+DEC Q     N  CKNTEGS++C+C +GY L      C+D+DECQ +       C NT
Sbjct: 1080 DIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNT 1139

Query: 2551 LGGFTCKCPPGFTQHHTA--CIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDAT 2608
             G F C C  G+        C D NEC    S+C  +G C NT GS+ C C  GF LD  
Sbjct: 1140 EGSFQCVCDQGYRASGLGDHCEDINECLEDKSVC-QRGDCINTAGSYDCTCPDGFQLD-D 1197

Query: 2609 GLNCEDVDECDGNHRC--QHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGS 2666
               C+D++EC+    C  Q  C N  G + C C QG+        C D +EC N   C S
Sbjct: 1198 NKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDS 1257

Query: 2667 -ASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYG-CSNTEGGYLCGCPP- 2723
               C NT GS++C C  GF   Q    C DVNEC      C    C N EG +LC C   
Sbjct: 1258 HGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADE 1317

Query: 2724 -GYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEACY 2763
               Y    G C S           LD +VD+      E  Y
Sbjct: 1318 NQEYSPMTGQCRSRTS------TDLDVDVDQPKEEKKECYY 1352



 Score =  218 bits (554), Expect = 9e-56
 Identities = 111/326 (34%), Positives = 155/326 (47%), Gaps = 47/326 (14%)

Query: 2445 TDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNY 2504
            T   +I+EC V P++C  G CIN    + C C  GY        C+D+DEC+Q    C+ 
Sbjct: 870  TQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQ 929

Query: 2505 -ICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCK------ 2557
              C+NTEGS+ C CP G++  E+G  C D+DEC       +  CVNT+G F C+      
Sbjct: 930  GRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGY 989

Query: 2558 ------------------------------------CPPGFTQHHTACIDNNECGSQPSL 2581
                                                C  GF   +  C+D +EC  +P++
Sbjct: 990  RMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDEC-LEPNV 1048

Query: 2582 CGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHG-CQNILGGYRCGCP 2640
            C A G C N  GS+ C C +G++      +C D+DEC   + C +G C+N  G +RC C 
Sbjct: 1049 C-ANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCG 1107

Query: 2641 QGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECS 2700
            QGY      +QC D +EC + + C    C NT GS++C C  G+        C D+NEC 
Sbjct: 1108 QGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECL 1167

Query: 2701 SSKNPCNYG-CSNTEGGYLCGCPPGY 2725
              K+ C  G C NT G Y C CP G+
Sbjct: 1168 EDKSVCQRGDCINTAGSYDCTCPDGF 1193



 Score =  209 bits (533), Expect = 2e-53
 Identities = 217/841 (25%), Positives = 301/841 (35%), Gaps = 202/841 (24%)

Query: 124  CSRPNMCTCSSGQISSTCGSKSIQQCSV--------------RCMNGGTCADDHCQCQKG 169
            C RP++C    G   +T G+   + C                 C+N  TC D+ C    G
Sbjct: 962  CLRPDVC--GEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPG 1019

Query: 170  YIGTYCGQPVCE-----NG-CQNGGRCIGPNRCA---C--VYGFTGPQCERDYRTGPCFT 218
               +Y   P  E     NG C +   C+ PN CA   C  + G     C + Y   P   
Sbjct: 1020 ---SYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHK 1076

Query: 219  QVNN-QMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDV 277
               +   CQ    G +C    C  T G      C         C +G+  +     C+D+
Sbjct: 1077 HCRDIDECQ---QGNLCVNGQCKNTEG---SFRCT--------CGQGYQLSAAKDQCEDI 1122

Query: 278  DECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNT 337
            DECQ    +C  G C NT GSF+C C  G++ S     CEDI+EC     +C+ G+C NT
Sbjct: 1123 DECQH-RHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINT 1181

Query: 338  VGSYFCVCPRGYVTSTDGSRCID----QRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
             GSY C CP G+    D   C D    +  G+C      G C            C C+ G
Sbjct: 1182 AGSYDCTCPDGFQLD-DNKTCQDINECEHPGLCGP---QGECL----NTEGSFHCVCQQG 1233

Query: 394  --------RCWGIGTIPE--ACPVRG-----SEEYRRLCMDGLP-----MGGIPGSAGSR 433
                     C  I        C   G     +  +R LC  G        G +  +    
Sbjct: 1234 FSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECEL 1293

Query: 434  PGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNG--FSPGVGGAGVGAGGQGPIITGLTIL 491
              G  G  F  +  G+        F+ +       +SP  G                T L
Sbjct: 1294 LSGVCGEAFCENVEGS--------FLCVCADENQEYSPMTGQCRSRTS---------TDL 1336

Query: 492  NQTIDICKHHANLC---LNGRCI------PTVSSYRCECNMGYKQDANGDCIDVDECTSN 542
            +  +D  K     C   LN   +      P V+   C C  G            D C   
Sbjct: 1337 DVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWG--------DNCEIF 1388

Query: 543  PCTNGDCVNTPGSYYCKCHAGFQRTPTKQACI--------DIDECIQNG-VLCKNGRCVN 593
            PC     V     +   C  G    P  ++          D DEC+  G  +CKNG C+N
Sbjct: 1389 PCP----VLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLN 1444

Query: 594  TDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNG 653
            T   ++C C  G         C D DEC   + C++G C+N +GS+ C C    VL  + 
Sbjct: 1445 TRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASE 1504

Query: 654  RYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKG 713
            + C    E        +   I     ++  C   L+                      + 
Sbjct: 1505 KRCIRPAE--------SNEQIEETDVYQDLCWEHLS---------------------DEY 1535

Query: 714  VCVRPFPG-AVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGR----- 767
            VC RP  G   T +ECCC   +  +G  C  CP K+S ++  LC+    I V GR     
Sbjct: 1536 VCSRPLVGKQTTYTECCCLYGE-AWGMQCALCPLKDSDDYAQLCN----IPVTGRRQPYG 1590

Query: 768  -------------------------------DINECALDPDICANGICENLRGSYRCNCN 796
                                              EC +  + C NG C  ++  Y C+C 
Sbjct: 1591 RDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGI-LNGCENGRCVRVQEGYTCDCF 1649

Query: 797  SGYEPDASGRNCIDIDEC--LVNRL-LCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDI 853
             GY  D +   C+D++EC  L NR+ LC N  C NT GSY C C PGYV   +   C  +
Sbjct: 1650 DGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPL 1709

Query: 854  N 854
            N
Sbjct: 1710 N 1710



 Score =  159 bits (402), Expect = 4e-38
 Identities = 178/745 (23%), Positives = 257/745 (34%), Gaps = 167/745 (22%)

Query: 62   EYREEGAAVASRVRRRGQQDVLRGPNVC---------GSRFHSYCCPGWKTLPGG----N 108
            EY + G  +  R R     + L  P+ C         GS     C  G++   G     +
Sbjct: 983  EYCDSGYRMTQRGRCEDIDECLN-PSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVD 1041

Query: 109  QCIVPICRNSCGDGFCSRPN---MCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQ 165
            +C+ P   N C +G CS      MC+C  G  + T   K  +     C  G  C +  C+
Sbjct: 1042 ECLEP---NVCANGDCSNLEGSYMCSCHKGY-TRTPDHKHCRDID-ECQQGNLCVNGQCK 1096

Query: 166  CQKGYIGTYCGQPV--------CEN--GCQNGGRCI--------GPNRCACVYGFT---- 203
              +G     CGQ          CE+   CQ+   C         G  +C C  G+     
Sbjct: 1097 NTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGL 1156

Query: 204  GPQCE---------RDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMC 254
            G  CE            + G C     +  C     G        C  I     HP  +C
Sbjct: 1157 GDHCEDINECLEDKSVCQRGDCINTAGSYDCTCP-DGFQLDDNKTCQDINEC-EHP-GLC 1213

Query: 255  PAQPQ----------PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCP 304
              Q +           C++GF  +     C+D+DEC         G C NT GSF C C 
Sbjct: 1214 GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCY 1273

Query: 305  AGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCP---RGYV---------TS 352
             G +  +  Q C D++EC ++ G+C    C N  GS+ CVC    + Y          TS
Sbjct: 1274 QGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTS 1333

Query: 353  TDGSRCIDQ---RTGMCFSGLVNGR-CAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVR 408
            TD    +DQ       C+  L +   C   L   +TK +CCC  G  WG       CPV 
Sbjct: 1334 TDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVL 1393

Query: 409  GSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFS 468
            G+ E+  +C                                   P G GF+P        
Sbjct: 1394 GTAEFTEMC-----------------------------------PKGKGFVP-------- 1410

Query: 469  PGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMG-YKQ 527
               G +   AGG+              +       +C NG C+ T   Y C C  G Y  
Sbjct: 1411 --AGESSSEAGGEN--------YKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYD 1460

Query: 528  DANGDCIDVDECTS-NPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACI---DIDECIQNG 583
                 C D+DEC   + C +G CVNT GSY C C        +++ CI   + +E I+  
Sbjct: 1461 PVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEET 1520

Query: 584  VLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCIC 643
             + ++    +    + C      + TT  + C  + E       L  +  ++D +  C  
Sbjct: 1521 DVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNI 1580

Query: 644  KPGFVLAPNGR---------YCTDVD------------------ECQTPGICMNGHCINS 676
                   P GR         Y  + D                  EC     C NG C+  
Sbjct: 1581 PVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRV 1640

Query: 677  EGSFRCDCPPGLAVGMDGRVCVDTH 701
            +  + CDC  G  +      CVD +
Sbjct: 1641 QEGYTCDCFDGYHLDTAKMTCVDVN 1665



 Score =  152 bits (383), Expect = 6e-36
 Identities = 144/559 (25%), Positives = 204/559 (36%), Gaps = 119/559 (21%)

Query: 86   PNVCGSR---------FHSYCCPGWKTLPGGNQCI-VPICRNSCGDGFCSRPNMCTCSSG 135
            P +CG +         FH  C  G+     G  C  +  C N+     C     C  ++G
Sbjct: 1210 PGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNT---VCDSHGFCDNTAG 1266

Query: 136  QISSTCGSKSIQQCSVRCMNGGTCAD-DHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPN 194
                 C      Q      +G  C D + C+   G     CG+  CEN  +    C+  +
Sbjct: 1267 SFRCLC-----YQGFQAPQDGQGCVDVNECELLSGV----CGEAFCEN-VEGSFLCVCAD 1316

Query: 195  RCACVYGFTGPQCERDYRTG-------------PCFTQVNN-QMCQGQLTGIVCTKTLCC 240
                    TG QC     T               C+  +N+  +C   L   V TK  CC
Sbjct: 1317 ENQEYSPMTG-QCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNV-TKQECC 1374

Query: 241  ATIGRAWGHPCEMCPA---------QPQPCRRGFIPNIRTGA------CQDVDECQAI-P 284
             T G  WG  CE+ P          +  P  +GF+P   + +       +D DEC     
Sbjct: 1375 CTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQ 1434

Query: 285  GICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCV 344
             IC+ G C+NT   +EC C  G        +C D+DEC   P  C  G+C NT GSY C 
Sbjct: 1435 EICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQ-DPSSCIDGQCVNTEGSYNCF 1493

Query: 345  CPRGYVTSTDGSRCI------------DQRTGMCFSGLVNGR-CAQELPGRMTK-MQCCC 390
            C    V      RCI            D    +C+  L +   C++ L G+ T   +CCC
Sbjct: 1494 CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCC 1553

Query: 391  EPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNG 450
              G  WG+      CP++ S++Y +LC        IP +   +P G      A       
Sbjct: 1554 LYGEAWGMQC--ALCPLKDSDDYAQLC-------NIPVTGRRQPYGRD----ALVDFSEQ 1600

Query: 451  YGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANL---CLN 507
            Y P                             P       LN   ++      +   C N
Sbjct: 1601 YTPEA--------------------------DPYFIQDRFLNSFEELQAEECGILNGCEN 1634

Query: 508  GRCIPTVSSYRCECNMGYKQD-ANGDCIDVDECTS-----NPCTNGDCVNTPGSYYCKCH 561
            GRC+     Y C+C  GY  D A   C+DV+EC       + C N  C+NT GSY C C 
Sbjct: 1635 GRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCL 1694

Query: 562  AGFQRTPTKQACIDIDECI 580
             G+  +     C  ++  +
Sbjct: 1695 PGYVPSDKPNYCTPLNTAL 1713



 Score =  132 bits (333), Expect = 4e-30
 Identities = 69/202 (34%), Positives = 103/202 (50%), Gaps = 19/202 (9%)

Query: 896  GTCWLNIQDSRCEVNINGATLKSECCATLGAAWG-SPCERCELDTA---------CPRGL 945
            G C+     S+C   + G + + +CC T+G +WG + C++C    +         C  G 
Sbjct: 557  GRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGY 616

Query: 946  ARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLD----IRME 1001
             R+    C+D+NEC++  GVCPNG C+N+ GS+ C C  G   D T   C+     I  E
Sbjct: 617  KRVNNTFCQDINECQL-QGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEE 675

Query: 1002 Q--CY-LKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGF 1058
            +  CY L     +C+HP+        CCC+VG AWG  CE+CP PGT  ++ +CP G G+
Sbjct: 676  KGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGY 735

Query: 1059 ANRGDVLTGRPFYKDINECKAF 1080
               G V   RP +  + +   F
Sbjct: 736  TVSG-VHRRRPIHHHVGKGPVF 756



 Score =  108 bits (269), Expect = 1e-22
 Identities = 57/134 (42%), Positives = 73/134 (54%), Gaps = 9/134 (6%)

Query: 2320 MCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTEC- 2378
            M  C PG  +R +   C D NEC+ + G+C NG C+N +GSYRC C  GF    + + C 
Sbjct: 609  MMECLPGY-KRVNNTFCQDINECQLQ-GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 666

Query: 2379 -----LDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQY 2433
                 +   +G C+  V      M   S +L TK  CCC  G+ WG  CE CPLPGTA +
Sbjct: 667  PDPPVISEEKGPCYRLVSSGRQCMHPLSVHL-TKQLCCCSVGKAWGPHCEKCPLPGTAAF 725

Query: 2434 KKICPHGPGYTTDG 2447
            K+ICP G GYT  G
Sbjct: 726  KEICPGGMGYTVSG 739



 Score =  101 bits (252), Expect = 9e-21
 Identities = 67/202 (33%), Positives = 93/202 (46%), Gaps = 49/202 (24%)

Query: 1603 RSSCCCSLGKAWG-NPCETCPPVNSTEYYT----LCPGGEGFRPNPITIILEDIDECQEL 1657
            +  CC ++G +WG N C+ CP   S   Y       PG +  R N      +DI+ECQ L
Sbjct: 578  QEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYK--RVN--NTFCQDINECQ-L 632

Query: 1658 PGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTC 1717
             G+C  G C+NT GS++C C  G+                      GP   ++     +C
Sbjct: 633  QGVCPNGECLNTMGSYRCTCKIGF----------------------GPDPTFS-----SC 665

Query: 1718 ICPPEYMQVNGGHNCMDMRKSFCYRSY-NGTTCENELPFNVTKRMCCCTYNVGKAWNKPC 1776
            +  P  +    G          CYR   +G  C + L  ++TK++CCC  +VGKAW   C
Sbjct: 666  VPDPPVISEEKGP---------CYRLVSSGRQCMHPLSVHLTKQLCCC--SVGKAWGPHC 714

Query: 1777 EPCPTPGTADFKTICGNIPGFT 1798
            E CP PGTA FK IC    G+T
Sbjct: 715  EKCPLPGTAAFKEICPGGMGYT 736



 Score = 96.3 bits (238), Expect = 4e-19
 Identities = 58/218 (26%), Positives = 87/218 (39%), Gaps = 51/218 (23%)

Query: 214 GPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWG-HPCEMCPAQPQ--------PCRRG 264
           G CF +     C   L G+   +  CC T+G +WG + C+ CP +P          C  G
Sbjct: 557 GRCFQETIGSQCGKALPGLSKQED-CCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPG 615

Query: 265 FIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSI 324
           +   +    CQD++ECQ + G+C  G C+NT+GS+ C C  G     T   C        
Sbjct: 616 Y-KRVNNTFCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC-------- 665

Query: 325 IPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGR-CAQELPGRM 383
                                             I +  G C+  + +GR C   L   +
Sbjct: 666 ----------------------------VPDPPVISEEKGPCYRLVSSGRQCMHPLSVHL 697

Query: 384 TKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGL 421
           TK  CCC  G+ WG     E CP+ G+  ++ +C  G+
Sbjct: 698 TKQLCCCSVGKAWGPHC--EKCPLPGTAAFKEICPGGM 733



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 45/130 (34%), Positives = 64/130 (49%), Gaps = 8/130 (6%)

Query: 643 CKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVD--- 699
           C PG+    N  +C D++ECQ  G+C NG C+N+ GS+RC C  G         CV    
Sbjct: 612 CLPGYKRV-NNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 670

Query: 700 --THMRSTCYGGIKKG-VCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 756
             +  +  CY  +  G  C+ P    +TK  CCC +    +G  C+ CP   +A F  +C
Sbjct: 671 VISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 729

Query: 757 SSGVGITVDG 766
             G+G TV G
Sbjct: 730 PGGMGYTVSG 739



 Score = 86.7 bits (213), Expect = 3e-16
 Identities = 67/200 (33%), Positives = 88/200 (44%), Gaps = 30/200 (15%)

Query: 1988 GRCFNE-IGSFKCLCNEGYELTPDGKNCIDT-------NECVALPGSCS-PGTCQNLEGS 2038
            GRCF E IGS    C +        ++C  T       N+C   P   S  G  Q +E  
Sbjct: 557  GRCFQETIGS---QCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMME-- 611

Query: 2039 FRCICPPGYE-VKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRC- 2096
                C PGY+ V +  C DINEC     +C  G C NT G ++C C  GF        C 
Sbjct: 612  ----CLPGYKRVNNTFCQDINECQLQ-GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 666

Query: 2097 -----FDTRQSFCFTNFENGK-CSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVA 2150
                     +  C+    +G+ C  P + + TK  CCCS   G+ WG  CE CP     A
Sbjct: 667  PDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSV--GKAWGPHCEKCPLPGTAA 724

Query: 2151 FQDLCPYGHG-TVPSLHDTR 2169
            F+++CP G G TV  +H  R
Sbjct: 725  FKEICPGGMGYTVSGVHRRR 744



 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 43/116 (37%), Positives = 56/116 (48%), Gaps = 10/116 (8%)

Query: 1530 CTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDN------RVGNCYLKF 1583
            C DI+EC     C NG C+NT G Y C C   F  +PT   CV +        G CY   
Sbjct: 624  CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLV 683

Query: 1584 GPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGF 1639
                     C   + V +++  CCCS+GKAWG  CE CP   +  +  +CPGG G+
Sbjct: 684  S----SGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGY 735



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 46/126 (36%), Positives = 69/126 (54%), Gaps = 10/126 (7%)

Query: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWG-HQCELCPL-PGTAQYKKICPHGP 2441
            G CF E + + C  A     L  + +CC   G  WG ++C+ CP  P    Y ++    P
Sbjct: 557  GRCFQETIGSQCGKALPG--LSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLP 614

Query: 2442 GY----TTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCI-DLDECS 2496
            GY     T  +DI+EC++   +C NG+C+NTMGS+RC CK+G+  D + +SC+ D    S
Sbjct: 615  GYKRVNNTFCQDINECQLQ-GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVIS 673

Query: 2497 QSPKPC 2502
            +   PC
Sbjct: 674  EEKGPC 679



 Score = 75.5 bits (184), Expect = 7e-13
 Identities = 49/174 (28%), Positives = 78/174 (44%), Gaps = 13/174 (7%)

Query: 945  LARIKGVTCEDVNECEVFPG---VCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRME 1001
            ++RI G T +   E +  PG   V   G  V    + H        +     V    ++ 
Sbjct: 500  VSRIDGPTGQKTKEAQ--PGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLG 557

Query: 1002 QCYLKWDEDECIHPVPGKFRMDACCCAVGAAWG-TECEECPK-PGTKEYETLCPRGAGFA 1059
            +C+ +    +C   +PG  + + CC  VG +WG  +C++CPK P    Y  +     G+ 
Sbjct: 558  RCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYK 617

Query: 1060 NRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNC 1113
                      F +DINEC+   G+C  G+C NT+GS++C C  GF  D    +C
Sbjct: 618  R-----VNNTFCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665



 Score = 74.7 bits (182), Expect = 1e-12
 Identities = 45/139 (32%), Positives = 57/139 (41%), Gaps = 18/139 (12%)

Query: 30  PQPPPPKPPRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQ---------- 79
           P PPPP+P RP  P  Q+     G      AP  ++    V S+V +  Q          
Sbjct: 101 PPPPPPEPARPAVPGGQLHPNPGGHPAA--APFTKQGRQVVRSKVPQETQSGGGSRLQVH 158

Query: 80  -QDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSC-GDGFCSRPNMCTCSSGQI 137
            +  L+G NVCG R    CC GW   PG  +C  P C   C   G C RP +C C  G  
Sbjct: 159 QKQQLQGVNVCGGR----CCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTK 214

Query: 138 SSTCGSKSIQQCSVRCMNG 156
              C + + Q  S     G
Sbjct: 215 GKACETIAAQDTSSPVFGG 233



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 62/239 (25%), Positives = 83/239 (34%), Gaps = 81/239 (33%)

Query: 715 CVRPFPGAVTKSECC-CANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECA 773
           C +  PG   + +CC      +GF + CQ CP K S  +HG                   
Sbjct: 568 CGKALPGLSKQEDCCGTVGTSWGFNK-CQKCPKKPS--YHGY------------------ 606

Query: 774 LDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSY 833
                  N + E L G  R N             C DI+EC +  + C NG C NT GSY
Sbjct: 607 -------NQMMECLPGYKRVN----------NTFCQDINECQLQGV-CPNGECLNTMGSY 648

Query: 834 SCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDS 893
            CTC  G+            + C  +P V                            I  
Sbjct: 649 RCTCKIGF------GPDPTFSSCVPDPPV----------------------------ISE 674

Query: 894 LKGTCWLNIQDSR-CEVNINGATLKSECCATLGAAWGSPCERCEL------DTACPRGL 945
            KG C+  +   R C   ++    K  CC ++G AWG  CE+C L         CP G+
Sbjct: 675 EKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGM 733



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 4/110 (3%)

Query: 1740 CYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPT-PGTADFKTICGNIPGFT 1798
            C++   G+ C   LP    +  CC T      +NK C+ CP  P    +  +   +PG+ 
Sbjct: 559  CFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNK-CQKCPKKPSYHGYNQMMECLPGYK 617

Query: 1799 FDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVC 1848
              ++     DI+EC ++ G+C NG C+N +GS+RC C  GF  +     C
Sbjct: 618  -RVNNTFCQDINEC-QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 52/201 (25%), Positives = 74/201 (36%), Gaps = 54/201 (26%)

Query: 520 ECNMGYKQDANGDCIDVDECT-SNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDE 578
           EC  GYK+  N  C D++EC     C NG+C+NT GSY C C  GF   PT  +C+    
Sbjct: 611 ECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 670

Query: 579 CIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGS 638
            I      + G C              + L + G+ C+       T              
Sbjct: 671 VISE----EKGPC--------------YRLVSSGRQCMHPLSVHLTKQL----------- 701

Query: 639 FKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCV 698
             C C  G    P+       ++C  PG            +F+  CP G+   + G    
Sbjct: 702 --CCCSVGKAWGPH------CEKCPLPG----------TAAFKEICPGGMGYTVSG---- 739

Query: 699 DTHMRSTCYGGIKKG-VCVRP 718
             H R   +  + KG V V+P
Sbjct: 740 -VHRRRPIHHHVGKGPVFVKP 759



 Score = 58.9 bits (141), Expect = 7e-08
 Identities = 49/168 (29%), Positives = 69/168 (41%), Gaps = 28/168 (16%)

Query: 109 QCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQK 168
           +C      + CG           C  G + ++ G    Q+C  +    G   +   +C  
Sbjct: 558 RCFQETIGSQCGKALPGLSKQEDCC-GTVGTSWGFNKCQKCPKKPSYHGY--NQMMECLP 614

Query: 169 GYI---GTYCG-------QPVCENG-CQNGGRCIGPNRCACVYGF----TGPQCERD--- 210
           GY     T+C        Q VC NG C N    +G  RC C  GF    T   C  D   
Sbjct: 615 GYKRVNNTFCQDINECQLQGVCPNGECLN---TMGSYRCTCKIGFGPDPTFSSCVPDPPV 671

Query: 211 --YRTGPCFTQVNN-QMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCP 255
                GPC+  V++ + C   L+ +  TK LCC ++G+AWG  CE CP
Sbjct: 672 ISEEKGPCYRLVSSGRQCMHPLS-VHLTKQLCCCSVGKAWGPHCEKCP 718



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 25/56 (44%), Positives = 28/56 (50%), Gaps = 1/56 (1%)

Query: 2652 CVDENECSNPNACGSASCYNTLGSYKCACPSGFSFD-QFSSACHDVNECSSSKNPC 2706
            C D NEC     C +  C NT+GSY+C C  GF  D  FSS   D    S  K PC
Sbjct: 624  CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 679



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 63/245 (25%), Positives = 86/245 (35%), Gaps = 69/245 (28%)

Query: 2099 TRQSFCFTNFENGKCSVPKAF-NTTKAKCCCSKMPGEGWG-DPCELCPKDDEVAFQDLCP 2156
            T+   CF      +C   KA    +K + CC  + G  WG + C+ CPK           
Sbjct: 554  TQLGRCFQETIGSQCG--KALPGLSKQEDCCGTV-GTSWGFNKCQKCPKK---------- 600

Query: 2157 YGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDE 2216
                  PS H   + +                        EC  GY        C D +E
Sbjct: 601  ------PSYHGYNQMM------------------------ECLPGYKR-VNNTFCQDINE 629

Query: 2217 CSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFR---CMNTFG 2273
            C +   C NG C N +GS+ C C  GF P P       + C  +P + +     C     
Sbjct: 630  CQLQGVCPNGECLNTMGSYRCTCKIGFGPDP-----TFSSCVPDPPVISEEKGPCYRLVS 684

Query: 2274 S-YECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKN--LIGT--FMCICPPGMA 2328
            S  +C  P+   L       K L  C+ G    ++ G  C+   L GT  F  ICP GM 
Sbjct: 685  SGRQCMHPLSVHL------TKQLCCCSVG----KAWGPHCEKCPLPGTAAFKEICPGGMG 734

Query: 2329 RRPDG 2333
                G
Sbjct: 735  YTVSG 739



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 32/94 (34%), Positives = 44/94 (46%), Gaps = 11/94 (11%)

Query: 1857 GDNLCQRNADCINSPGSY----RCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQ 1912
            G N CQ+   C   P  +      EC  G+K   N  C D NEC ++  VC +G C++  
Sbjct: 590  GFNKCQK---CPKKPSYHGYNQMMECLPGYKRVNNTFCQDINEC-QLQGVCPNGECLNTM 645

Query: 1913 GSYQCICHNGFKASQDQTMCM---DVDECERHPC 1943
            GSY+C C  GF      + C+    V   E+ PC
Sbjct: 646  GSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 679



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 20/43 (46%), Positives = 27/43 (62%), Gaps = 1/43 (2%)

Query: 1447 CSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSC 1489
            C D++EC     +C NG+CLN  G+YRC C++GF P     SC
Sbjct: 624  CQDINECQLQ-GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665



 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 39/135 (28%), Positives = 58/135 (42%), Gaps = 27/135 (20%)

Query: 1067 GRPFYKDI-NEC-KAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPD 1124
            GR F + I ++C KA PG+     C  T+G+     + GF             +C   P 
Sbjct: 557  GRCFQETIGSQCGKALPGLSKQEDCCGTVGT-----SWGF---------NKCQKCPKKPS 602

Query: 1125 LCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCD 1184
              G    +        EC  GY+   +    C DI+EC+   + C  G C+NT GS++C 
Sbjct: 603  YHGYNQMM--------ECLPGYKR--VNNTFCQDINECQLQGV-CPNGECLNTMGSYRCT 651

Query: 1185 CPLGHELSPSREDCV 1199
            C +G    P+   CV
Sbjct: 652  CKIGFGPDPTFSSCV 666



 Score = 46.2 bits (108), Expect = 5e-04
 Identities = 39/139 (28%), Positives = 59/139 (42%), Gaps = 29/139 (20%)

Query: 1919 CHNGFKASQDQTMCMDVDECE-RHPCGNGTCKNTVGSYNCLCYPGF--ELTHNNDCLD-- 1973
            C  G+K   + T C D++EC+ +  C NG C NT+GSY C C  GF  + T ++   D  
Sbjct: 612  CLPGYKRVNN-TFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 670

Query: 1974 --IDECSSFFGQVCRNGRCFNEIG----SFKCLCNEGYELTPDGKNCIDTNECVALPGSC 2027
               +E    +  V    +C + +        C C+ G    P  + C        LPG+ 
Sbjct: 671  VISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKC-------PLPGT- 722

Query: 2028 SPGTCQNLEGSFRCICPPG 2046
                      +F+ ICP G
Sbjct: 723  ---------AAFKEICPGG 732



 Score = 45.4 bits (106), Expect = 8e-04
 Identities = 40/141 (28%), Positives = 59/141 (41%), Gaps = 34/141 (24%)

Query: 1813 KEIPGICANGVCINQIGSF----RCE-CPTGFSY---NDLL-----------LVCEDIDE 1853
            K +PG+     C   +G+     +C+ CP   SY   N ++             C+DI+E
Sbjct: 570  KALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINE 629

Query: 1854 CSNGDNLCQRNADCINSPGSYRCECAAGFKLSPN-GACV--------DRNECLEIPN--- 1901
            C     +C  N +C+N+ GSYRC C  GF   P   +CV        ++  C  + +   
Sbjct: 630  CQL-QGVCP-NGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGR 687

Query: 1902 VCSHGLCVDLQGSYQCICHNG 1922
             C H L V L     C C  G
Sbjct: 688  QCMHPLSVHLT-KQLCCCSVG 707



 Score = 45.4 bits (106), Expect = 8e-04
 Identities = 28/91 (30%), Positives = 40/91 (43%), Gaps = 7/91 (7%)

Query: 1195 REDCVDINECSLSDNLCRNGKCVNMIGTY----QCSCNPGYQATPDRQGCTDIDECMIMN 1250
            +EDC      S   N C+  KC      +       C PGY+   +   C DI+EC +  
Sbjct: 578  QEDCCGTVGTSWGFNKCQ--KCPKKPSYHGYNQMMECLPGYKRV-NNTFCQDINECQLQG 634

Query: 1251 GGCDTQCTNSEGSYECSCSEGYALMPDGRSC 1281
               + +C N+ GSY C+C  G+   P   SC
Sbjct: 635  VCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 36/134 (26%), Positives = 51/134 (38%), Gaps = 15/134 (11%)

Query: 2557 KCPPGFTQ-HHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNC--- 2612
            +C PG+ + ++T C D NEC  Q  +C   G C NT GS+ C C+ GF  D T  +C   
Sbjct: 611  ECLPGYKRVNNTFCQDINECQLQ-GVC-PNGECLNTMGSYRCTCKIGFGPDPTFSSCVPD 668

Query: 2613 -----EDVDEC----DGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNA 2663
                 E+   C        +C H     L    C C  G        +C      +    
Sbjct: 669  PPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEI 728

Query: 2664 CGSASCYNTLGSYK 2677
            C     Y   G ++
Sbjct: 729  CPGGMGYTVSGVHR 742



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 35/140 (25%), Positives = 53/140 (37%), Gaps = 23/140 (16%)

Query: 43  PPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLRGPNVCGSRFHSYCCPGWK 102
           P Q+  S    +EG F     +++ AA        G+  V+  P++C             
Sbjct: 315 PAQKGISGEQSTEGSFPLRYVQDQVAAPFQLSNHTGRIKVVFTPSICKVT---------- 364

Query: 103 TLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQ--CSVRCMNGGTCA 160
                  C    C+NSC  G           +G  + T  + + +   C + CMNGG C+
Sbjct: 365 -------CTKGSCQNSCEKG---NTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCS 414

Query: 161 D-DHCQCQKGYIGTYCGQPV 179
             D CQC   + G  C  PV
Sbjct: 415 SRDKCQCPPNFTGKLCQIPV 434



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 18/43 (41%), Positives = 25/43 (58%), Gaps = 1/43 (2%)

Query: 1323 CIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGC 1365
            C D+NEC L   +C  GEC NT GS+ C C++G+      + C
Sbjct: 624  CQDINECQLQG-VCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665



 Score = 43.1 bits (100), Expect = 0.004
 Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 2/57 (3%)

Query: 1268 CSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCI 1324
            C  GY  + +   C DI+EC+    +C  G+C N  G YRC C  GF       +C+
Sbjct: 612  CLPGYKRV-NNTFCQDINECQLQ-GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 666



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 44/172 (25%), Positives = 65/172 (37%), Gaps = 31/172 (18%)

Query: 2454 KVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSY 2513
            K +P L     C  T+G+   F K                 C + PK  +Y   N     
Sbjct: 570  KALPGLSKQEDCCGTVGTSWGFNK-----------------CQKCPKKPSYHGYNQ---- 608

Query: 2514 QCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHT--ACID 2571
               C  GY  + +   C+D++ECQ +       C+NT+G + C C  GF    T  +C+ 
Sbjct: 609  MMECLPGYK-RVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVP 667

Query: 2572 NNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDAT-GLNCEDVDECDGNH 2622
            +      P +   KG C     S   +C    S+  T  L C  V +  G H
Sbjct: 668  D-----PPVISEEKGPCYRLVSS-GRQCMHPLSVHLTKQLCCCSVGKAWGPH 713



 Score = 41.2 bits (95), Expect = 0.015
 Identities = 34/123 (27%), Positives = 48/123 (39%), Gaps = 14/123 (11%)

Query: 1402 NGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDV-------DECA 1454
            N   C D++EC         N +C+NT GSYRC C  GF  D    S V       +E  
Sbjct: 620  NNTFCQDINECQ--LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKG 677

Query: 1455 ENINLCENG-QCLNVPGAY----RCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNL 1509
                L  +G QC++    +     C C +G         C      +F+ IC  G    +
Sbjct: 678  PCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTV 737

Query: 1510 PGM 1512
             G+
Sbjct: 738  SGV 740



 Score = 38.5 bits (88), Expect = 0.098
 Identities = 62/290 (21%), Positives = 93/290 (32%), Gaps = 64/290 (22%)

Query: 158 TCADDHCQ--CQKGYIGTYCGQP---------------VCENGCQNGGRCIGPNRCACVY 200
           TC    CQ  C+KG   T   +                +C   C NGG+C   ++C C  
Sbjct: 364 TCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCP- 422

Query: 201 GFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATI-GRAWG-------HPCE 252
                         P FT    ++CQ  + G    K    +   G+A G       H   
Sbjct: 423 --------------PNFT---GKLCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLP 465

Query: 253 MCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSET 312
           +     Q  +  F PNI     +   E             I+ V   +   P G K  E 
Sbjct: 466 LTVTSQQGVKVKFPPNIVNIHVKHPPEASVQ---------IHQVSRIDG--PTGQKTKEA 514

Query: 313 TQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVN 372
                 +    +     +T    ++  S+  V P  Y  +         + G CF   + 
Sbjct: 515 QPGQSQVSYQGLPVQKTQT---IHSTYSHQQVIPHVYPVAAK------TQLGRCFQETIG 565

Query: 373 GRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLP 422
            +C + LPG   +  CC   G  WG     + CP + S       M+ LP
Sbjct: 566 SQCGKALPGLSKQEDCCGTVGTSWGFNKC-QKCPKKPSYHGYNQMMECLP 614



 Score = 35.8 bits (81), Expect = 0.64
 Identities = 16/48 (33%), Positives = 27/48 (56%), Gaps = 3/48 (6%)

Query: 1352 CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW 1399
            C  GY  +   T C D++EC++       +  CLN  GS++C+C+ G+
Sbjct: 612  CLPGYK-RVNNTFCQDINECQL--QGVCPNGECLNTMGSYRCTCKIGF 656



 Score = 35.8 bits (81), Expect = 0.64
 Identities = 15/36 (41%), Positives = 22/36 (61%), Gaps = 1/36 (2%)

Query: 493 QTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQD 528
           Q I+ C+    +C NG C+ T+ SYRC C +G+  D
Sbjct: 625 QDINECQLQG-VCPNGECLNTMGSYRCTCKIGFGPD 659



 Score = 34.7 bits (78), Expect = 1.4
 Identities = 24/74 (32%), Positives = 33/74 (44%), Gaps = 12/74 (16%)

Query: 2498 SPKPCNYICKNTEGSYQCSCPRGY---VLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGF 2554
            +P  C   C  T+GS Q SC +G    ++ E+G     L     +   C   C+N  GG 
Sbjct: 357  TPSICKVTC--TKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMN--GGQ 412

Query: 2555 T-----CKCPPGFT 2563
                  C+CPP FT
Sbjct: 413  CSSRDKCQCPPNFT 426



 Score = 33.1 bits (74), Expect = 4.1
 Identities = 14/33 (42%), Positives = 16/33 (48%)

Query: 2693 CHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGY 2725
            C D+NEC       N  C NT G Y C C  G+
Sbjct: 624  CQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 656


>gi|46249412 latent transforming growth factor beta binding protein 1
            isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score =  472 bits (1215), Expect = e-132
 Identities = 288/891 (32%), Positives = 411/891 (46%), Gaps = 128/891 (14%)

Query: 1894 NECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECER--HPCGNGTCKNT 1951
            NEC   P++C  G C++L   Y CIC+ G++ S+ Q  C+D+DEC +  H C  G C+NT
Sbjct: 550  NECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENT 609

Query: 1952 VGSYNCLCYPGFELTHNN-DCLDIDECSSFFGQVCRNGRCFNEIGSFKC-LCNEGYELTP 2009
             GS+ C+C  GF  +    +C+D+DEC      VC  G C N +G+F+C  C+ GY +T 
Sbjct: 610  EGSFLCICPAGFMASEEGTNCIDVDECLR--PDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 667

Query: 2010 DGKNCIDTNECVALPGSCSPGTCQNLEGSFRCI-CPPGYEVKSENCIDINECDEDPNICL 2068
             G+ C D +EC+  P +C    C N  GS++C+ C  G+   +  C+D++EC E PN+C 
Sbjct: 668  RGR-CEDIDECLN-PSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLE-PNVCA 724

Query: 2069 FGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCC 2128
             G C+N  G + C C  G+  + + + C D  +        NG+C               
Sbjct: 725  NGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQC--------------- 769

Query: 2129 SKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCI 2188
                            K+ E +F+  C  G+  + +  D  ED++EC +   +C++GQC 
Sbjct: 770  ----------------KNTEGSFRCTCGQGY-QLSAAKDQCEDIDEC-QHRHLCAHGQCR 811

Query: 2189 NTDGSFRCECPMGYNLDYTGVRCVDTDEC-SIGNPCGNGTCTNVIGSFECNCNEGFEPGP 2247
            NT+GSF+C C  GY     G  C D +EC    + C  G C N  GS++C C +GF+   
Sbjct: 812  NTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDD 871

Query: 2248 MMNCEDINECAQNPLLCAFR--CMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDC 2305
               C+DINEC ++P LC  +  C+NT GS+ C C  G+++  D + C+D+DEC      C
Sbjct: 872  NKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTV-C 929

Query: 2306 ESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCEC 2365
            +S G  C N  G+F C+C  G     DG+GCVD NEC    G+C    C N+ GS+ C C
Sbjct: 930  DSHGF-CDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVC 988

Query: 2366 NEGFQSSSSGT-ECLDNRQGLCFAEVLQTICQMASSSRNL-------------VTKSECC 2411
             +  Q  S  T +C          +V Q   +      NL             VTK ECC
Sbjct: 989  ADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECC 1048

Query: 2412 CDGGRGWGHQCEL--CPLPGTAQYKKICPHGPGYTTDG-----------RDIDECKVM-P 2457
            C  G GWG  CE+  CP+ GTA++ ++CP G G+   G           +D DEC +   
Sbjct: 1049 CTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQ 1108

Query: 2458 NLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPC-NYICKNTEGSYQCS 2516
             +C NG C+NT   + C+CK G   D     C D+DEC Q P  C +  C NTEGSY C 
Sbjct: 1109 EICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDEC-QDPSSCIDGQCVNTEGSYNCF 1167

Query: 2517 CPRGYVLQEDGKTC-------KDLDECQTKQHNC------QFLCVNTLGGFTCKCPPGFT 2563
            C    VL    K C       + ++E    Q  C      +++C   L G         T
Sbjct: 1168 CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQT------T 1221

Query: 2564 QHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHR 2623
                 C+     G Q +LC  K          S +  +  ++  TG             R
Sbjct: 1222 YTECCCLYGEAWGMQCALCPLKD---------SDDYAQLCNIPVTG------------RR 1260

Query: 2624 CQHGCQNILGGYRCGCPQG---YIQHYQWNQC--VDENECSNPNACGSASCYNTLGSYKC 2678
              +G   ++       P+    +IQ    N    +   EC   N C +  C      Y C
Sbjct: 1261 QPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTC 1320

Query: 2679 ACPSGFSFDQFSSACHDVNECSSSKNPC----NYGCSNTEGGYLCGCPPGY 2725
             C  G+  D     C DVNEC    N      N  C NT+G Y C C PGY
Sbjct: 1321 DCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGY 1371



 Score =  467 bits (1202), Expect = e-131
 Identities = 283/864 (32%), Positives = 409/864 (47%), Gaps = 144/864 (16%)

Query: 1158 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCV 1217
            +I+EC  NP +C  G C+N    + C C  G+  S  +  CVDI+EC+   +LC  G+C 
Sbjct: 548  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 607

Query: 1218 NMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECS-CSEGYALMP 1276
            N  G++ C C  G+ A+ +   C D+DEC+  +   +  C N+ G++ C  C  GY +  
Sbjct: 608  NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 667

Query: 1277 DGRSCADIDECENNPDICDGGQCTNIPGEYRCL-CYDGFMASMDMKTCIDVNECDLNSNI 1335
             GR C DIDEC  NP  C   QC N PG Y+C+ C +GF        C+DV+EC L  N+
Sbjct: 668  RGR-CEDIDEC-LNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ--CLDVDEC-LEPNV 722

Query: 1336 CMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSC 1395
            C  G+C N +GS++C C  GY+       C D+DEC+ G  N  ++  C N  GSF+C+C
Sbjct: 723  CANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQG--NLCVNGQCKNTEGSFRCTC 780

Query: 1396 REGWIGNGIK--CIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF--TGDGFTCSDVD 1451
             +G+  +  K  C D+DEC +  H C+ + QC NT GS++C C +G+  +G G  C D++
Sbjct: 781  GQGYQLSAAKDQCEDIDECQH-RHLCA-HGQCRNTEGSFQCVCDQGYRASGLGDHCEDIN 838

Query: 1452 ECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNIC-VFGTCNNLP 1510
            EC E+ ++C+ G C+N  G+Y C C  GF    D+++CQDI+EC    +C   G C N  
Sbjct: 839  ECLEDKSVCQRGDCINTAGSYDCTCPDGF-QLDDNKTCQDINECEHPGLCGPQGECLNTE 897

Query: 1511 GMFHCICDDGYELDRTGGNCTDIDECADPINC-VNGLCVNTPGRYECNCPPDFQLNPTGV 1569
            G FHC+C  G+ +   G  C DIDEC +   C  +G C NT G + C C   FQ    G 
Sbjct: 898  GSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQ 957

Query: 1570 GCVDNRVGNCYLKFGPRG-------DGSLSC--------------------NTEIGV--- 1599
            GCVD  V  C L  G  G       +GS  C                    +T++ V   
Sbjct: 958  GCVD--VNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVD 1015

Query: 1600 -------------------------GVSRSSCCCSLGKAWGNPCE--TCPPVNSTEYYTL 1632
                                      V++  CCC+ G  WG+ CE   CP + + E+  +
Sbjct: 1016 QPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEM 1075

Query: 1633 CPGGEGFRPNPITII------LEDIDEC----QELPGLCQGGNCINTFGSFQCECPQGYY 1682
            CP G+GF P   +         +D DEC    QE   +C+ G C+NT   ++C C QG Y
Sbjct: 1076 CPKGKGFVPAGESSSEAGGENYKDADECLLFGQE---ICKNGFCLNTRPGYECYCKQGTY 1132

Query: 1683 LSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCM--------- 1733
                   C D+DEC   P  C  G C NT G+Y C C    +       C+         
Sbjct: 1133 YDPVKLQCFDMDEC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQI 1191

Query: 1734 ---DMRKSFCYRSYNGT-TCENEL-PFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFK 1788
               D+ +  C+   +    C   L     T   CCC Y  G+AW   C  CP   + D+ 
Sbjct: 1192 EETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLY--GEAWGMQCALCPLKDSDDYA 1249

Query: 1789 TICGNI--------------------------PGFTFD--IHTGKAVDIDECKEIPGICA 1820
             +C NI                          P F  D  +++ + +  +EC  + G C 
Sbjct: 1250 QLC-NIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNG-CE 1307

Query: 1821 NGVCINQIGSFRCECPTGFSYNDLLLVCEDIDEC---SNGDNLCQRNADCINSPGSYRCE 1877
            NG C+     + C+C  G+  +   + C D++EC   +N  +LC +NA CIN+ GSY+C 
Sbjct: 1308 NGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLC-KNAKCINTDGSYKCL 1366

Query: 1878 CAAGFKLS--PNGACVDRNECLEI 1899
            C  G+  S  PN  C   N  L +
Sbjct: 1367 CLPGYVPSDKPN-YCTPLNTALNL 1389



 Score =  456 bits (1172), Expect = e-127
 Identities = 294/856 (34%), Positives = 394/856 (46%), Gaps = 99/856 (11%)

Query: 1283 DIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECE 1342
            +I+EC  NPDIC  G C N+P  Y C+CY+G+  S   + C+D++EC    ++C  G CE
Sbjct: 548  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 607

Query: 1343 NTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCS-CREGW-I 1400
            NT+GSF+C C  G+   +  T C DVDEC +    C     C+N  G+F+C  C  G+ +
Sbjct: 608  NTEGSFLCICPAGFMASEEGTNCIDVDEC-LRPDVCG-EGHCVNTVGAFRCEYCDSGYRM 665

Query: 1401 GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCA-CSEGFTGDGFTCSDVDECAENINL 1459
                +C D+DEC N +  C  + QCVN+PGSY+C  C+EGF G    C DVDEC E  N+
Sbjct: 666  TQRGRCEDIDECLNPS-TCP-DEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEP-NV 722

Query: 1460 CENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDD 1519
            C NG C N+ G+Y C C  G+T   D + C+DIDEC   N+CV G C N  G F C C  
Sbjct: 723  CANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQ 782

Query: 1520 GYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNC 1579
            GY+L      C DIDEC     C +G C NT G ++C C   ++ +  G  C D  +  C
Sbjct: 783  GYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCED--INEC 840

Query: 1580 Y--LKFGPRGD-----GSLSCNTEIGVGVSRSSCCCSLGKAWGNPCE---TCPPVN---S 1626
                    RGD     GS  C    G  +  +  C  +     N CE    C P     +
Sbjct: 841  LEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDI-----NECEHPGLCGPQGECLN 895

Query: 1627 TEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSED 1686
            TE    C   +GF  +      EDIDEC         G C NT GSF+C C QG+   +D
Sbjct: 896  TEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQD 955

Query: 1687 TRICEDIDECFAHPGVCGPGTCYNTLGNYTCICP---PEYMQVNG---GHNCMDM----- 1735
             + C D++EC    GVCG   C N  G++ C+C     EY  + G        D+     
Sbjct: 956  GQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVD 1015

Query: 1736 ----RKSFCYRSYN-GTTCENELPFNVTKRMCCCTYNVGKAWNKPCE--PCPTPGTADFK 1788
                 K  CY + N  + C+N L  NVTK+ CCCT   G  W   CE  PCP  GTA+F 
Sbjct: 1016 QPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAG--WGDNCEIFPCPVLGTAEFT 1073

Query: 1789 TIC----GNIPGFTFDIHTG--KAVDIDECKEI-PGICANGVCINQIGSFRCECPTGFSY 1841
             +C    G +P        G     D DEC      IC NG C+N    + C C  G  Y
Sbjct: 1074 EMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYY 1133

Query: 1842 NDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKL-SPNGACV---DRNECL 1897
            + + L C D+DEC +  +    +  C+N+ GSY C C     L +    C+   + NE +
Sbjct: 1134 DPVKLQCFDMDECQDPSSCI--DGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQI 1191

Query: 1898 EIPN--------------VCSHGLCVDLQGSY-QCICHNGFKASQDQTMC--MDVDEC-- 1938
            E  +              VCS  L V  Q +Y +C C  G        +C   D D+   
Sbjct: 1192 EETDVYQDLCWEHLSDEYVCSRPL-VGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQ 1250

Query: 1939 --------ERHPCGNGTCKNTVGSYNCLCYPGF---ELTHNNDCLDIDECSSFFGQVCRN 1987
                     R P G     +    Y     P F      ++ + L  +EC    G  C N
Sbjct: 1251 LCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNG--CEN 1308

Query: 1988 GRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGS---CSPGTCQNLEGSFRCICP 2044
            GRC      + C C +GY L      C+D NEC  L      C    C N +GS++C+C 
Sbjct: 1309 GRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCL 1368

Query: 2045 PGY--EVKSENCIDIN 2058
            PGY    K   C  +N
Sbjct: 1369 PGYVPSDKPNYCTPLN 1384



 Score =  416 bits (1069), Expect = e-115
 Identities = 279/877 (31%), Positives = 392/877 (44%), Gaps = 124/877 (14%)

Query: 535  DVDECTSNP--CTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCV 592
            +++ECT NP  C  G C+N P  Y C C+ G++ +  ++ C+DIDEC Q   LC  GRC 
Sbjct: 548  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 607

Query: 593  NTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKC-ICKPGFVLAP 651
            NT+GSF CIC AGF  + +G NC+D DEC   ++C  G C+N  G+F+C  C  G+ +  
Sbjct: 608  NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 667

Query: 652  NGRYCTDVDECQTPGICMNGHCINSEGSFRC-DCPPGLAVGMDGRVCVDTHMRSTCYGGI 710
             GR C D+DEC  P  C +  C+NS GS++C  C  G   G +G+ C+D      C   +
Sbjct: 668  RGR-CEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFR-GWNGQ-CLDV---DEC---L 718

Query: 711  KKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDG---- 766
            +  VC       +  S  C  +  Y      + C   +  +   LC +G     +G    
Sbjct: 719  EPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRC 778

Query: 767  ---------------RDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDI 811
                            DI+EC     +CA+G C N  GS++C C+ GY     G +C DI
Sbjct: 779  TCGQGYQLSAAKDQCEDIDECQ-HRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDI 837

Query: 812  DECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCV---NGACRN 868
            +ECL ++ +C  G C NT GSY CTCP G+    + +TC+DINECE +P +    G C N
Sbjct: 838  NECLEDKSVCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDINECE-HPGLCGPQGECLN 895

Query: 869  NLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAW 928
              GSF+C C  G  +S+ G  C D              C VN         C  T G+  
Sbjct: 896  TEGSFHCVCQQGFSISADGRTCEDI-----------DEC-VNNTVCDSHGFCDNTAGSF- 942

Query: 929  GSPCERCELDTACPRGL-ARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPE--- 984
                 RC     C +G  A   G  C DVNECE+  GVC    C N +GSF C C +   
Sbjct: 943  -----RC----LCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQ 993

Query: 985  ---GLTLDGTGRVCLDIRME---------QCYLKW-DEDECIHPVPGKFRMDACCCAVGA 1031
                +T     R   D+ ++         +CY    D   C + +        CCC  GA
Sbjct: 994  EYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGA 1053

Query: 1032 AWGTECE--ECPKPGTKEYETLCPRGAGFANRGDVLT--GRPFYKDINECKAF-PGMCTY 1086
             WG  CE   CP  GT E+  +CP+G GF   G+  +  G   YKD +EC  F   +C  
Sbjct: 1054 GWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKN 1113

Query: 1087 GKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGY 1146
            G C NT   ++C C  G   D  +  C D+DEC+  P  C  G CVNT GS+ C C    
Sbjct: 1114 GFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQ-DPSSCIDGQCVNTEGSYNCFCTHPM 1172

Query: 1147 ESGFMMMKNCM-------DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCV 1199
                   K C+        I+E +    LC      +    + C  PL  + +   E C 
Sbjct: 1173 VLD-ASEKRCIRPAESNEQIEETDVYQDLC----WEHLSDEYVCSRPLVGKQTTYTECCC 1227

Query: 1200 DINE--------CSLSDN-----LCR-----------NGKCVNMIGTYQCSCNPGYQATP 1235
               E        C L D+     LC                V+    Y    +P +    
Sbjct: 1228 LYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDR 1287

Query: 1236 DRQGCTDI--DECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECE---NN 1290
                  ++  +EC I+NG  + +C   +  Y C C +GY L     +C D++EC+   N 
Sbjct: 1288 FLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNR 1347

Query: 1291 PDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVN 1327
              +C   +C N  G Y+CLC  G++ S     C  +N
Sbjct: 1348 MSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384



 Score =  414 bits (1064), Expect = e-115
 Identities = 299/942 (31%), Positives = 406/942 (43%), Gaps = 170/942 (18%)

Query: 852  DINECESNP--CVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNI-QDSRCE 908
            +INEC  NP  C  G C N    + C C  G + S     C+D  + T   ++    RCE
Sbjct: 548  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 607

Query: 909  VNINGATLKSECCATLGAAWGSPCERCELDTACPRG-LARIKGVTCEDVNECEVFPGVCP 967
             N  G+ L                        CP G +A  +G  C DV+EC + P VC 
Sbjct: 608  -NTEGSFL----------------------CICPAGFMASEEGTNCIDVDEC-LRPDVCG 643

Query: 968  NGRCVNSKGSFHCE-CPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACC 1026
             G CVN+ G+F CE C  G  +   GR C DI           DEC++P       D  C
Sbjct: 644  EGHCVNTVGAFRCEYCDSGYRMTQRGR-CEDI-----------DECLNPSTCP---DEQC 688

Query: 1027 CAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTY 1086
              V +    +C  C + G + +   C                    D++EC   P +C  
Sbjct: 689  --VNSPGSYQCVPCTE-GFRGWNGQC-------------------LDVDECLE-PNVCAN 725

Query: 1087 GKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGY 1146
            G C N  GS+ C C+ G+    + ++C DIDEC+   +LC +G C NT GSF C C +GY
Sbjct: 726  GDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQ-QGNLCVNGQCKNTEGSFRCTCGQGY 784

Query: 1147 ESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSL 1206
            +        C DIDEC+   L C  G C NTEGSFQC C  G+  S   + C DINEC  
Sbjct: 785  QLS-AAKDQCEDIDECQHRHL-CAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLE 842

Query: 1207 SDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQ--CTNSEGSY 1264
              ++C+ G C+N  G+Y C+C  G+Q   D + C DI+EC    G C  Q  C N+EGS+
Sbjct: 843  DKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINECE-HPGLCGPQGECLNTEGSF 900

Query: 1265 ECSCSEGYALMPDGRSCADIDECENNPDICDG-GQCTNIPGEYRCLCYDGFMASMDMKTC 1323
             C C +G+++  DGR+C DIDEC NN  +CD  G C N  G +RCLCY GF A  D + C
Sbjct: 901  HCVCQQGFSISADGRTCEDIDECVNN-TVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGC 959

Query: 1324 IDVNECDLNSNICMFGECENTKGSFICHC---QLGYSVKKG-----TTGCTDVD------ 1369
            +DVNEC+L S +C    CEN +GSF+C C      YS   G     T+   DVD      
Sbjct: 960  VDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKE 1019

Query: 1370 ECEIGAHNCDMHASCLNI--PGSFK--CSCREGWIGNGIKCIDLDECSNGTHQCSINAQC 1425
            E +   +N +  + C N+  P   K  C C  G  G G  C        GT        C
Sbjct: 1020 EKKECYYNLNDASLCDNVLAPNVTKQECCCTSG-AGWGDNCEIFPCPVLGT--AEFTEMC 1076

Query: 1426 VNTPGSYRCACSEGFTGDGFTCSDVDEC-AENINLCENGQCLNVPGAYRCECEMGFTPAS 1484
                G      S    G G    D DEC      +C+NG CLN    Y C C+ G     
Sbjct: 1077 PKGKGFVPAGESSSEAG-GENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDP 1135

Query: 1485 DSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNC---TDIDECADPIN 1541
                C D+DEC   + C+ G C N  G ++C C     LD +   C    + +E  +  +
Sbjct: 1136 VKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETD 1195

Query: 1542 CVNGLC-VNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVG 1600
                LC  +    Y C+ P                                     +G  
Sbjct: 1196 VYQDLCWEHLSDEYVCSRP------------------------------------LVGKQ 1219

Query: 1601 VSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLC---------PGG--------EGFRPNP 1643
             + + CCC  G+AWG  C  CP  +S +Y  LC         P G        E + P  
Sbjct: 1220 TTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEA 1279

Query: 1644 ITIILED----------IDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDI 1693
                ++D           +EC  L G C+ G C+     + C+C  GY+L      C D+
Sbjct: 1280 DPYFIQDRFLNSFEELQAEECGILNG-CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDV 1338

Query: 1694 DECFA---HPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNC 1732
            +EC        +C    C NT G+Y C+C P Y+  +  + C
Sbjct: 1339 NECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYC 1380



 Score =  414 bits (1064), Expect = e-115
 Identities = 283/852 (33%), Positives = 384/852 (45%), Gaps = 158/852 (18%)

Query: 1796 GFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECS 1855
            G+ F     K VDIDEC ++  +C+ G C N  GSF C CP GF  ++    C D+DEC 
Sbjct: 578  GYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECL 637

Query: 1856 NGDNLCQRNADCINSPGSYRCE-CAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGS 1914
              D +C     C+N+ G++RCE C +G++++  G C D +ECL  P+ C    CV+  GS
Sbjct: 638  RPD-VCGEG-HCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLN-PSTCPDEQCVNSPGS 694

Query: 1915 YQCI-CHNGFKASQDQTMCMDVDEC-ERHPCGNGTCKNTVGSYNCLCYPGFELTHNND-C 1971
            YQC+ C  GF+    Q  C+DVDEC E + C NG C N  GSY C C+ G+  T ++  C
Sbjct: 695  YQCVPCTEGFRGWNGQ--CLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHC 752

Query: 1972 LDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGT 2031
             DIDEC    G +C NG+C N  GSF+C C +GY+L+     C D +EC      C+ G 
Sbjct: 753  RDIDECQQ--GNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRH-LCAHGQ 809

Query: 2032 CQNLEGSFRCICPPGYEVKS--ENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVL 2089
            C+N EGSF+C+C  GY      ++C DINEC ED ++C  G C NT G + C CP GF L
Sbjct: 810  CRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL 869

Query: 2090 SDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEV 2149
             DN + C D  +           C  P                  G   P   C  + E 
Sbjct: 870  DDN-KTCQDINE-----------CEHP------------------GLCGPQGEC-LNTEG 898

Query: 2150 AFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGV 2209
            +F  +C  G  ++ +   T ED++EC+ +    S+G C NT GSFRC C  G+     G 
Sbjct: 899  SFHCVCQQGF-SISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQ 957

Query: 2210 RCVDTDECSI-GNPCGNGTCTNVIGSFECNC-NEGFEPGPMMN-C--------------- 2251
             CVD +EC +    CG   C NV GSF C C +E  E  PM   C               
Sbjct: 958  GCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQP 1017

Query: 2252 -EDINECAQNPLLCAFRCMNTFG----SYECTCPIG--------------YALREDQKMC 2292
             E+  EC  N L  A  C N         EC C  G                  E  +MC
Sbjct: 1018 KEEKKECYYN-LNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMC 1076

Query: 2293 ---------------------KDLDECAE-GLHDCESRGMMCKNLIGTFMCICPPGMARR 2330
                                 KD DEC   G   C++    C N    + C C  G    
Sbjct: 1077 PKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNG--FCLNTRPGYECYCKQGTYYD 1134

Query: 2331 PDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECL---DNRQGLCF 2387
            P    C D +EC+  P  C +G+CVN  GSY C C       +S   C+   ++ + +  
Sbjct: 1135 PVKLQCFDMDECQD-PSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEE 1193

Query: 2388 AEVLQTICQMASS-----SRNLVTK----SECCCDGGRGWGHQCELCPLPGTAQYKKIC- 2437
             +V Q +C    S     SR LV K    +ECCC  G  WG QC LCPL  +  Y ++C 
Sbjct: 1194 TDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCN 1253

Query: 2438 --------PHGPGYTTDGRD-----------------------IDECKVMPNLCTNGQCI 2466
                    P+G     D  +                        +EC ++ N C NG+C+
Sbjct: 1254 IPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGIL-NGCENGRCV 1312

Query: 2467 NTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPC----NYICKNTEGSYQCSCPRGYV 2522
                 + C C  GY  D +  +C+D++EC +         N  C NT+GSY+C C  GYV
Sbjct: 1313 RVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYV 1372

Query: 2523 LQEDGKTCKDLD 2534
              +    C  L+
Sbjct: 1373 PSDKPNYCTPLN 1384



 Score =  392 bits (1006), Expect = e-108
 Identities = 278/918 (30%), Positives = 388/918 (42%), Gaps = 190/918 (20%)

Query: 1448 SDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECS-FQNICVFGTC 1506
            ++++EC  N ++C  G C+N+P  Y C C  G+  +   R C DIDEC+  Q++C  G C
Sbjct: 547  TEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRC 606

Query: 1507 NNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECN-CPPDFQLN 1565
             N  G F CIC  G+     G NC D+DEC  P  C  G CVNT G + C  C   +++ 
Sbjct: 607  ENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMT 666

Query: 1566 PTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN 1625
              G  C D  +  C                     ++ S+C          P E C  VN
Sbjct: 667  QRG-RCED--IDEC---------------------LNPSTC----------PDEQC--VN 690

Query: 1626 STEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSE 1685
            S   Y   P  EGFR      +  D+DEC E P +C  G+C N  GS+ C C +GY  + 
Sbjct: 691  SPGSYQCVPCTEGFRGWNGQCL--DVDECLE-PNVCANGDCSNLEGSYMCSCHKGYTRTP 747

Query: 1686 DTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYN 1745
            D + C DIDEC     +C  G C NT G++ C C   Y        C D+ +        
Sbjct: 748  DHKHCRDIDEC-QQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDE-------- 798

Query: 1746 GTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGK 1805
               C++       + +C      G+  N       T G+  F+ +C    G+        
Sbjct: 799  ---CQH-------RHLCAH----GQCRN-------TEGS--FQCVCDQ--GYRASGLGDH 833

Query: 1806 AVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNA 1865
              DI+EC E   +C  G CIN  GS+ C CP GF  +D    C+DI+EC +   LC    
Sbjct: 834  CEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNK-TCQDINECEH-PGLCGPQG 891

Query: 1866 DCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFK 1924
            +C+N+ GS+ C C  GF +S +G  C D +EC+      SHG C +  GS++C+C+ GF+
Sbjct: 892  ECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 951

Query: 1925 ASQDQTMCMDVDECE--RHPCGNGTCKNTVGSYNCLC---------YPGFELTHNNDCLD 1973
            A QD   C+DV+ECE     CG   C+N  GS+ C+C           G   +  +  LD
Sbjct: 952  APQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLD 1011

Query: 1974 ID---------ECSSFFGQ--VCRNGRCFNEIGSFKCLCNEGY----------------- 2005
            +D         EC        +C N    N +   +C C  G                  
Sbjct: 1012 VDVDQPKEEKKECYYNLNDASLCDNVLAPN-VTKQECCCTSGAGWGDNCEIFPCPVLGTA 1070

Query: 2006 ---ELTPDGKNCI---------------DTNECVALPGS-CSPGTCQNLEGSFRCICPPG 2046
               E+ P GK  +               D +EC+      C  G C N    + C C  G
Sbjct: 1071 EFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQG 1130

Query: 2047 --YEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCF------- 2097
              Y+     C D++EC +DP+ C+ G C NT G + C C    VL  + +RC        
Sbjct: 1131 TYYDPVKLQCFDMDEC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNE 1189

Query: 2098 -----DTRQSFCFTNFENGK-CSVPKAFN-TTKAKCCCSKMPGEGWGDPCELCPKDDEVA 2150
                 D  Q  C+ +  +   CS P     TT  +CCC  + GE WG  C LCP  D   
Sbjct: 1190 QIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCC--LYGEAWGMQCALCPLKDSDD 1247

Query: 2151 FQDLC---------PYGHGTVPSLHD--TRE-----------------DVNECLESPGIC 2182
            +  LC         PYG   +    +  T E                    EC    G C
Sbjct: 1248 YAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNG-C 1306

Query: 2183 SNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNP----CGNGTCTNVIGSFECN 2238
             NG+C+     + C+C  GY+LD   + CVD +EC   N     C N  C N  GS++C 
Sbjct: 1307 ENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCL 1366

Query: 2239 CNEGFEPGPMMN-CEDIN 2255
            C  G+ P    N C  +N
Sbjct: 1367 CLPGYVPSDKPNYCTPLN 1384



 Score =  371 bits (952), Expect = e-102
 Identities = 261/851 (30%), Positives = 363/851 (42%), Gaps = 183/851 (21%)

Query: 2016 DTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPNICLFGSCT 2073
            + NEC   P  C  G C NL   + CIC  GY    +   C+DI+EC +  ++C  G C 
Sbjct: 548  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 607

Query: 2074 NTPGGFQCLCPPGFVLSDNGRRCFDT---------------------RQSFCFTNF---E 2109
            NT G F C+CP GF+ S+ G  C D                      R  +C + +   +
Sbjct: 608  NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 667

Query: 2110 NGKC-SVPKAFN-TTKAKCCCSKMPG-----------EGWGDPC---------ELCPKDD 2147
             G+C  + +  N +T     C   PG            GW   C          +C   D
Sbjct: 668  RGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGD 727

Query: 2148 ----EVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYN 2203
                E ++   C  G+   P  H    D++EC +   +C NGQC NT+GSFRC C  GY 
Sbjct: 728  CSNLEGSYMCSCHKGYTRTPD-HKHCRDIDEC-QQGNLCVNGQCKNTEGSFRCTCGQGYQ 785

Query: 2204 LDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFE-PGPMMNCEDINECAQNPL 2262
            L     +C D DEC   + C +G C N  GSF+C C++G+   G   +CEDINEC ++  
Sbjct: 786  LSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKS 845

Query: 2263 LC-AFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAE-GLHDCESRGMMCKNLIGTFM 2320
            +C    C+NT GSY+CTCP G+ L +D K C+D++EC   GL  C  +G  C N  G+F 
Sbjct: 846  VCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDINECEHPGL--CGPQG-ECLNTEGSFH 901

Query: 2321 CICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLD 2380
            C+C  G +   DG  C D +EC        +G C N  GS+RC C +GFQ+   G  C+D
Sbjct: 902  CVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVD 961

Query: 2381 NRQ-----GLC---FAEVLQ----TICQMASSSRNLVT---------------------K 2407
              +     G+C   F E ++     +C   +   + +T                     K
Sbjct: 962  VNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEK 1021

Query: 2408 SEC-----------------------CCDGGRGWGHQCEL--CPLPGTAQYKKICPHGPG 2442
             EC                       CC  G GWG  CE+  CP+ GTA++ ++CP G G
Sbjct: 1022 KECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKG 1081

Query: 2443 YTTDG-----------RDIDECKVM-PNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCI 2490
            +   G           +D DEC +    +C NG C+NT   + C+CK G   D     C 
Sbjct: 1082 FVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCF 1141

Query: 2491 DLDECSQSPKPC-NYICKNTEGSYQCSCPRGYVLQEDGKTC-------KDLDECQTKQHN 2542
            D+DEC Q P  C +  C NTEGSY C C    VL    K C       + ++E    Q  
Sbjct: 1142 DMDEC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDL 1200

Query: 2543 C------QFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKG------ICQN 2590
            C      +++C   L G         T     C+     G Q +LC  K       +C N
Sbjct: 1201 CWEHLSDEYVCSRPLVG------KQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLC-N 1253

Query: 2591 TP-----------------GSFSCECQRGFSLDATGLNCEDV--DECDGNHRCQHG-CQN 2630
             P                   ++ E    F  D    + E++  +EC   + C++G C  
Sbjct: 1254 IPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVR 1313

Query: 2631 ILGGYRCGCPQGYIQHYQWNQCVDENECSNPN----ACGSASCYNTLGSYKCACPSGFSF 2686
            +  GY C C  GY        CVD NEC   N     C +A C NT GSYKC C  G+  
Sbjct: 1314 VQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVP 1373

Query: 2687 DQFSSACHDVN 2697
                + C  +N
Sbjct: 1374 SDKPNYCTPLN 1384



 Score =  364 bits (935), Expect = e-100
 Identities = 253/793 (31%), Positives = 350/793 (44%), Gaps = 153/793 (19%)

Query: 495  IDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANG-DCIDVDEC-TSNPCTNGDCVNT 552
            ID C    +LC  GRC  T  S+ C C  G+     G +CIDVDEC   + C  G CVNT
Sbjct: 591  IDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNT 650

Query: 553  PGSYYCK-CHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCI-CNAGFELTT 610
             G++ C+ C +G++ T  +  C DIDEC+ N   C + +CVN+ GS+QC+ C  GF    
Sbjct: 651  VGAFRCEYCDSGYRMT-QRGRCEDIDECL-NPSTCPDEQCVNSPGSYQCVPCTEGFR--- 705

Query: 611  DGKN--CVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGIC 668
             G N  C+D DEC   N+C NG C N +GS+ C C  G+   P+ ++C D+DECQ   +C
Sbjct: 706  -GWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLC 764

Query: 669  MNGHCINSEGSFRCDCPPGLAVGMDGRVCVD----THMRSTCYG------GIKKGVCVRP 718
            +NG C N+EGSFRC C  G  +      C D     H     +G      G  + VC + 
Sbjct: 765  VNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQG 824

Query: 719  FPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDG----RDINECAL 774
            +  +     C   N        CQ     N+A  +  C+   G  +D     +DINEC  
Sbjct: 825  YRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYD-CTCPDGFQLDDNKTCQDINECE- 882

Query: 775  DPDICA-NGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCD-NGLCRNTPGS 832
             P +C   G C N  GS+ C C  G+   A GR C DIDEC VN  +CD +G C NT GS
Sbjct: 883  HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGS 941

Query: 833  YSCTCPPGYVFRTETETCEDINECE--SNPCVNGACRNNLGSFNCECSPGSK-------- 882
            + C C  G+    + + C D+NECE  S  C    C N  GSF C C+  ++        
Sbjct: 942  FRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQ 1001

Query: 883  ---LSSTGL-ICID---SLKGTCWLNIQD-SRCEVNINGATLKSECCATLGAAWGSPCE- 933
                +ST L + +D     K  C+ N+ D S C+  +     K ECC T GA WG  CE 
Sbjct: 1002 CRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEI 1061

Query: 934  -------RCELDTACPRGLARIK---------GVTCEDVNECEVF--------------- 962
                     E    CP+G   +          G   +D +EC +F               
Sbjct: 1062 FPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRP 1121

Query: 963  ---------------------------PGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVC 995
                                       P  C +G+CVN++GS++C C   + LD + + C
Sbjct: 1122 GYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRC 1181

Query: 996  L------------DIRMEQCYLKW-DEDECIHPVPGK-FRMDACCCAVGAAWGTECEECP 1041
            +            D+  + C+    DE  C  P+ GK      CCC  G AWG +C  CP
Sbjct: 1182 IRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCP 1241

Query: 1042 KPGTKEYETLC---------PRG----AGFANRGDVLTGRPFYKD----------INECK 1078
               + +Y  LC         P G      F+ +        F +D            EC 
Sbjct: 1242 LKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECG 1301

Query: 1079 AFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDEC-----RISPDLCGSGICVN 1133
               G C  G+C      + C C  G+ LD  +  C D++EC     R+S  LC +  C+N
Sbjct: 1302 ILNG-CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMS--LCKNAKCIN 1358

Query: 1134 TPGSFECECFEGY 1146
            T GS++C C  GY
Sbjct: 1359 TDGSYKCLCLPGY 1371



 Score =  363 bits (933), Expect = 1e-99
 Identities = 252/812 (31%), Positives = 364/812 (44%), Gaps = 113/812 (13%)

Query: 503  NLCLNGRCIPTVSSYRCE-CNMGYKQDANGDCIDVDECTS-NPCTNGDCVNTPGSYYC-K 559
            ++C  G C+ TV ++RCE C+ GY+    G C D+DEC + + C +  CVN+PGSY C  
Sbjct: 640  DVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVP 699

Query: 560  CHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHD 619
            C  GF+    +  C+D+DEC++  V C NG C N +GS+ C C+ G+  T D K+C D D
Sbjct: 700  CTEGFRGWNGQ--CLDVDECLEPNV-CANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDID 756

Query: 620  ECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGS 679
            EC   N+C+NG C N +GSF+C C  G+ L+     C D+DECQ   +C +G C N+EGS
Sbjct: 757  ECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGS 816

Query: 680  FRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGE 739
            F+C C  G      G  C D +         ++G C+       T     C  PD GF  
Sbjct: 817  FQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCIN------TAGSYDCTCPD-GF-- 867

Query: 740  PCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICA-NGICENLRGSYRCNCNSG 798
                       + +  C          +DINEC   P +C   G C N  GS+ C C  G
Sbjct: 868  ---------QLDDNKTC----------QDINECE-HPGLCGPQGECLNTEGSFHCVCQQG 907

Query: 799  YEPDASGRNCIDIDECLVNRLLCDN-GLCRNTPGSYSCTCPPGYVFRTETETCEDINECE 857
            +   A GR C DIDEC VN  +CD+ G C NT GS+ C C  G+    + + C D+NECE
Sbjct: 908  FSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECE 966

Query: 858  --SNPCVNGACRNNLGSFNCECSPGSK-----------LSSTGL-ICIDSLKGT---CWL 900
              S  C    C N  GSF C C+  ++            +ST L + +D  K     C+ 
Sbjct: 967  LLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYY 1026

Query: 901  NIQD-SRCEVNINGATLKSECCATLGAAWGSPCE--------RCELDTACPRGLARIK-- 949
            N+ D S C+  +     K ECC T GA WG  CE          E    CP+G   +   
Sbjct: 1027 NLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAG 1086

Query: 950  -------GVTCEDVNECEVF-PGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRME 1001
                   G   +D +EC +F   +C NG C+N++  + C C +G   D     C D  M+
Sbjct: 1087 ESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFD--MD 1144

Query: 1002 QCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANR 1061
            +C    D   CI         D  C     ++   C         E   + P     A  
Sbjct: 1145 ECQ---DPSSCI---------DGQCVNTEGSYNCFCTHPMVLDASEKRCIRP-----AES 1187

Query: 1062 GDVLTGRPFYKDIN-ECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCT--DIDE 1118
             + +     Y+D+  E  +   +C+           +C C  G A  M+   C   D D+
Sbjct: 1188 NEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDD 1247

Query: 1119 ----CRISP----DLCGSGICVNTPGSFECECFEGY-ESGFMMMKNCMDIDECERNPLL- 1168
                C I         G    V+    +  E    + +  F+     +  +EC    +L 
Sbjct: 1248 YAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECG---ILN 1304

Query: 1169 -CRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDN---LCRNGKCVNMIGTYQ 1224
             C  G CV  +  + CDC  G+ L  ++  CVD+NEC   +N   LC+N KC+N  G+Y+
Sbjct: 1305 GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYK 1364

Query: 1225 CSCNPGYQATPDRQGCTDIDECMIMNGGCDTQ 1256
            C C PGY  +     CT ++  + +    D +
Sbjct: 1365 CLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE 1396



 Score =  362 bits (930), Expect = 2e-99
 Identities = 249/824 (30%), Positives = 346/824 (41%), Gaps = 134/824 (16%)

Query: 276  DVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECS 335
            +++EC   P IC  G+CIN    + C C  G++ SE  +KC DIDEC+ +  +C  G C 
Sbjct: 548  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 607

Query: 336  NTVGSYFCVCPRGYVTSTDGSRCIDQRT---------GMCFSGLVNGRCAQELPG-RMTK 385
            NT GS+ C+CP G++ S +G+ CID            G C + +   RC     G RMT+
Sbjct: 608  NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 667

Query: 386  MQCCCEPGRCWGIGTIPEACPVRGSEEYRRL-CMDGLP--MGGIPGSAGSRPGGTGGNGF 442
               C +   C    T P+   V     Y+ + C +G     G               NG 
Sbjct: 668  RGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGD 727

Query: 443  APSGNGNGYGPGGTGFIPIPGG----------------NGFSPGVGGAGVGAGGQGPIIT 486
              +  G+       G+   P                  NG      G+     GQG  ++
Sbjct: 728  CSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLS 787

Query: 487  GLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGD-CIDVDECTSNP-- 543
                  + ID C+H  +LC +G+C  T  S++C C+ GY+    GD C D++EC  +   
Sbjct: 788  AAKDQCEDIDECQHR-HLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSV 846

Query: 544  CTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICN 603
            C  GDC+NT GSY C C  GFQ    K  C DI+EC   G+    G C+NT+GSF C+C 
Sbjct: 847  CQRGDCINTAGSYDCTCPDGFQLDDNK-TCQDINECEHPGLCGPQGECLNTEGSFHCVCQ 905

Query: 604  AGFELTTDGKNCVDHDECTTTNMC-LNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDEC 662
             GF ++ DG+ C D DEC    +C  +G C N  GSF+C+C  GF    +G+ C DV+EC
Sbjct: 906  QGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNEC 965

Query: 663  Q-TPGICMNGHCINSEGSFRC--------------DCPPGLAVGMDGRVCVDTHMRSTCY 707
            +   G+C    C N EGSF C               C    +  +D  V      +  CY
Sbjct: 966  ELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECY 1025

Query: 708  GGIK-KGVCVRPFPGAVTKSECCCANPDYGFGEPCQ--PCPAKNSAEFHGLCSSGVGITV 764
              +    +C       VTK ECCC +   G+G+ C+  PCP   +AEF  +C  G G   
Sbjct: 1026 YNLNDASLCDNVLAPNVTKQECCCTS-GAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVP 1084

Query: 765  DG-----------RDINECAL-DPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDID 812
             G           +D +EC L   +IC NG C N R  Y C C  G   D     C D+D
Sbjct: 1085 AGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMD 1144

Query: 813  ECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGS 872
            EC  +   C +G C NT GSY+C C    V     + C  I   ESN  +          
Sbjct: 1145 EC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRC--IRPAESNEQIEET------- 1194

Query: 873  FNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSR-CEVNING-ATLKSECCATLGAAWGS 930
                               D  +  CW ++ D   C   + G  T  +ECC   G AWG 
Sbjct: 1195 -------------------DVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGM 1235

Query: 931  PCERCELDTA------C---------PRGLARIKGVTCE--------------------- 954
             C  C L  +      C         P G   +   + +                     
Sbjct: 1236 QCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEEL 1295

Query: 955  DVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDI 998
               EC +  G C NGRCV  +  + C+C +G  LD     C+D+
Sbjct: 1296 QAEECGILNG-CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDV 1338



 Score =  349 bits (895), Expect = 3e-95
 Identities = 270/920 (29%), Positives = 388/920 (42%), Gaps = 146/920 (15%)

Query: 743  PCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPD 802
            P P + + E     +S V       +INEC ++PDIC  G C NL   Y C C  GY   
Sbjct: 523  PVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFS 582

Query: 803  ASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINEC-ESNPC 861
               R C+DIDEC   + LC  G C NT GS+ C CP G++   E   C D++EC   + C
Sbjct: 583  EQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVC 642

Query: 862  VNGACRNNLGSFNCE-CSPGSKLSSTGLICIDSLKGTCWLNIQDSRCE---VNINGATLK 917
              G C N +G+F CE C  G +++  G                  RCE     +N +T  
Sbjct: 643  GEGHCVNTVGAFRCEYCDSGYRMTQRG------------------RCEDIDECLNPSTCP 684

Query: 918  SECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGS 977
             E C     ++     +C     C  G     G  C DV+EC + P VC NG C N +GS
Sbjct: 685  DEQCVNSPGSY-----QC---VPCTEGFRGWNG-QCLDVDEC-LEPNVCANGDCSNLEGS 734

Query: 978  FHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTEC 1037
            + C C +G T     + C DI           DEC              C  G    TE 
Sbjct: 735  YMCSCHKGYTRTPDHKHCRDI-----------DEC---------QQGNLCVNGQCKNTE- 773

Query: 1038 EECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFK 1097
                      +   C +G   +   D        +DI+EC+    +C +G+CRNT GSF+
Sbjct: 774  --------GSFRCTCGQGYQLSAAKDQC------EDIDECQ-HRHLCAHGQCRNTEGSFQ 818

Query: 1098 CRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCM 1157
            C C+ G+       +C DI+EC     +C  G C+NT GS++C C +G++      K C 
Sbjct: 819  CVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQ--LDDNKTCQ 876

Query: 1158 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLC-RNGKC 1216
            DI+ECE   L    G C+NTEGSF C C  G  +S     C DI+EC +++ +C  +G C
Sbjct: 877  DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFC 935

Query: 1217 VNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGC-DTQCTNSEGSYECSC---SEGY 1272
             N  G+++C C  G+QA  D QGC D++EC +++G C +  C N EGS+ C C   ++ Y
Sbjct: 936  DNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEY 995

Query: 1273 ALMPD---GRSCADID-----------ECE---NNPDICDGGQCTNIPGEYRCLCYDGFM 1315
            + M      R+  D+D           EC    N+  +CD     N+  +  C C  G  
Sbjct: 996  SPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVT-KQECCCTSG-- 1052

Query: 1316 ASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGA 1375
                     ++  C +         C   KG F+   +   S + G     D DEC +  
Sbjct: 1053 --AGWGDNCEIFPCPVLGTAEFTEMCPKGKG-FVPAGE--SSSEAGGENYKDADECLLFG 1107

Query: 1376 HNCDMHASCLNIPGSFKCSCREGWIGNGIK--CIDLDECSNGTHQCSINAQCVNTPGSYR 1433
                 +  CLN    ++C C++G   + +K  C D+DEC + +    I+ QCVNT GSY 
Sbjct: 1108 QEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPS--SCIDGQCVNTEGSYN 1165

Query: 1434 CACSEGFTGDG--------------FTCSDV--DECAENIN---LCENGQCLNVPGAYRC 1474
            C C+     D                  +DV  D C E+++   +C             C
Sbjct: 1166 CFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTEC 1225

Query: 1475 ECEMGFTPASDSRSCQDIDECSFQNIC-VFGTCNNLPGMFHCICD---------DGYEL- 1523
             C  G         C   D   +  +C +  T    P     + D         D Y + 
Sbjct: 1226 CCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQ 1285

Query: 1524 DRTGGNCTDI--DECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVD-------- 1573
            DR   +  ++  +EC     C NG CV     Y C+C   + L+   + CVD        
Sbjct: 1286 DRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELN 1345

Query: 1574 NRVGNCYLKFGPRGDGSLSC 1593
            NR+  C        DGS  C
Sbjct: 1346 NRMSLCKNAKCINTDGSYKC 1365



 Score =  320 bits (821), Expect = 1e-86
 Identities = 190/521 (36%), Positives = 244/521 (46%), Gaps = 52/521 (9%)

Query: 2253 DINECAQNPLLC-AFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMM 2311
            +INEC  NP +C A  C+N    Y C C  GY   E Q+ C D+DEC +  H C S+G  
Sbjct: 548  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLC-SQGR- 605

Query: 2312 CKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCE-CNEGFQ 2370
            C+N  G+F+CICP G     +G  C+D +EC  +P +C  G CVN +G++RCE C+ G++
Sbjct: 606  CENTEGSFLCICPAGFMASEEGTNCIDVDEC-LRPDVCGEGHCVNTVGAFRCEYCDSGYR 664

Query: 2371 SSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGT 2430
             +  G  C D  + L  +      C  +  S   V     C +G RGW  QC        
Sbjct: 665  MTQRG-RCEDIDECLNPSTCPDEQCVNSPGSYQCVP----CTEGFRGWNGQC-------- 711

Query: 2431 AQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCI 2490
                              D+DEC + PN+C NG C N  GS+ C C  GYT       C 
Sbjct: 712  -----------------LDVDEC-LEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCR 753

Query: 2491 DLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNT 2550
            D+DEC Q     N  CKNTEGS++C+C +GY L      C+D+DECQ +       C NT
Sbjct: 754  DIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNT 813

Query: 2551 LGGFTCKCPPGFTQHHTA--CIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDAT 2608
             G F C C  G+        C D NEC    S+C  +G C NT GS+ C C  GF LD  
Sbjct: 814  EGSFQCVCDQGYRASGLGDHCEDINECLEDKSVC-QRGDCINTAGSYDCTCPDGFQLD-D 871

Query: 2609 GLNCEDVDECDGNHRC--QHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGS 2666
               C+D++EC+    C  Q  C N  G + C C QG+        C D +EC N   C S
Sbjct: 872  NKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDS 931

Query: 2667 -ASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYG-CSNTEGGYLCGCPP- 2723
               C NT GS++C C  GF   Q    C DVNEC      C    C N EG +LC C   
Sbjct: 932  HGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADE 991

Query: 2724 -GYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEACY 2763
               Y    G C S           LD +VD+      E  Y
Sbjct: 992  NQEYSPMTGQCRSRTS------TDLDVDVDQPKEEKKECYY 1026



 Score =  218 bits (554), Expect = 9e-56
 Identities = 111/326 (34%), Positives = 155/326 (47%), Gaps = 47/326 (14%)

Query: 2445 TDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNY 2504
            T   +I+EC V P++C  G CIN    + C C  GY        C+D+DEC+Q    C+ 
Sbjct: 544  TQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQ 603

Query: 2505 -ICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCK------ 2557
              C+NTEGS+ C CP G++  E+G  C D+DEC       +  CVNT+G F C+      
Sbjct: 604  GRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGY 663

Query: 2558 ------------------------------------CPPGFTQHHTACIDNNECGSQPSL 2581
                                                C  GF   +  C+D +EC  +P++
Sbjct: 664  RMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDEC-LEPNV 722

Query: 2582 CGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHG-CQNILGGYRCGCP 2640
            C A G C N  GS+ C C +G++      +C D+DEC   + C +G C+N  G +RC C 
Sbjct: 723  C-ANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCG 781

Query: 2641 QGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECS 2700
            QGY      +QC D +EC + + C    C NT GS++C C  G+        C D+NEC 
Sbjct: 782  QGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECL 841

Query: 2701 SSKNPCNYG-CSNTEGGYLCGCPPGY 2725
              K+ C  G C NT G Y C CP G+
Sbjct: 842  EDKSVCQRGDCINTAGSYDCTCPDGF 867



 Score =  209 bits (533), Expect = 2e-53
 Identities = 217/841 (25%), Positives = 301/841 (35%), Gaps = 202/841 (24%)

Query: 124  CSRPNMCTCSSGQISSTCGSKSIQQCSV--------------RCMNGGTCADDHCQCQKG 169
            C RP++C    G   +T G+   + C                 C+N  TC D+ C    G
Sbjct: 636  CLRPDVC--GEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPG 693

Query: 170  YIGTYCGQPVCE-----NG-CQNGGRCIGPNRCA---C--VYGFTGPQCERDYRTGPCFT 218
               +Y   P  E     NG C +   C+ PN CA   C  + G     C + Y   P   
Sbjct: 694  ---SYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHK 750

Query: 219  QVNN-QMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDV 277
               +   CQ    G +C    C  T G      C         C +G+  +     C+D+
Sbjct: 751  HCRDIDECQ---QGNLCVNGQCKNTEG---SFRCT--------CGQGYQLSAAKDQCEDI 796

Query: 278  DECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNT 337
            DECQ    +C  G C NT GSF+C C  G++ S     CEDI+EC     +C+ G+C NT
Sbjct: 797  DECQH-RHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINT 855

Query: 338  VGSYFCVCPRGYVTSTDGSRCID----QRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
             GSY C CP G+    D   C D    +  G+C      G C            C C+ G
Sbjct: 856  AGSYDCTCPDGFQLD-DNKTCQDINECEHPGLCGP---QGECL----NTEGSFHCVCQQG 907

Query: 394  --------RCWGIGTIPE--ACPVRG-----SEEYRRLCMDGLP-----MGGIPGSAGSR 433
                     C  I        C   G     +  +R LC  G        G +  +    
Sbjct: 908  FSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECEL 967

Query: 434  PGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNG--FSPGVGGAGVGAGGQGPIITGLTIL 491
              G  G  F  +  G+        F+ +       +SP  G                T L
Sbjct: 968  LSGVCGEAFCENVEGS--------FLCVCADENQEYSPMTGQCRSRTS---------TDL 1010

Query: 492  NQTIDICKHHANLC---LNGRCI------PTVSSYRCECNMGYKQDANGDCIDVDECTSN 542
            +  +D  K     C   LN   +      P V+   C C  G            D C   
Sbjct: 1011 DVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWG--------DNCEIF 1062

Query: 543  PCTNGDCVNTPGSYYCKCHAGFQRTPTKQACI--------DIDECIQNG-VLCKNGRCVN 593
            PC     V     +   C  G    P  ++          D DEC+  G  +CKNG C+N
Sbjct: 1063 PCP----VLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLN 1118

Query: 594  TDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNG 653
            T   ++C C  G         C D DEC   + C++G C+N +GS+ C C    VL  + 
Sbjct: 1119 TRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASE 1178

Query: 654  RYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKG 713
            + C    E        +   I     ++  C   L+                      + 
Sbjct: 1179 KRCIRPAE--------SNEQIEETDVYQDLCWEHLS---------------------DEY 1209

Query: 714  VCVRPFPG-AVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGR----- 767
            VC RP  G   T +ECCC   +  +G  C  CP K+S ++  LC+    I V GR     
Sbjct: 1210 VCSRPLVGKQTTYTECCCLYGE-AWGMQCALCPLKDSDDYAQLCN----IPVTGRRQPYG 1264

Query: 768  -------------------------------DINECALDPDICANGICENLRGSYRCNCN 796
                                              EC +  + C NG C  ++  Y C+C 
Sbjct: 1265 RDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGI-LNGCENGRCVRVQEGYTCDCF 1323

Query: 797  SGYEPDASGRNCIDIDEC--LVNRL-LCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDI 853
             GY  D +   C+D++EC  L NR+ LC N  C NT GSY C C PGYV   +   C  +
Sbjct: 1324 DGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPL 1383

Query: 854  N 854
            N
Sbjct: 1384 N 1384



 Score =  159 bits (402), Expect = 4e-38
 Identities = 178/745 (23%), Positives = 257/745 (34%), Gaps = 167/745 (22%)

Query: 62   EYREEGAAVASRVRRRGQQDVLRGPNVC---------GSRFHSYCCPGWKTLPGG----N 108
            EY + G  +  R R     + L  P+ C         GS     C  G++   G     +
Sbjct: 657  EYCDSGYRMTQRGRCEDIDECLN-PSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVD 715

Query: 109  QCIVPICRNSCGDGFCSRPN---MCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQ 165
            +C+ P   N C +G CS      MC+C  G  + T   K  +     C  G  C +  C+
Sbjct: 716  ECLEP---NVCANGDCSNLEGSYMCSCHKGY-TRTPDHKHCRDID-ECQQGNLCVNGQCK 770

Query: 166  CQKGYIGTYCGQPV--------CEN--GCQNGGRCI--------GPNRCACVYGFT---- 203
              +G     CGQ          CE+   CQ+   C         G  +C C  G+     
Sbjct: 771  NTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGL 830

Query: 204  GPQCE---------RDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMC 254
            G  CE            + G C     +  C     G        C  I     HP  +C
Sbjct: 831  GDHCEDINECLEDKSVCQRGDCINTAGSYDCTCP-DGFQLDDNKTCQDINEC-EHP-GLC 887

Query: 255  PAQPQ----------PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCP 304
              Q +           C++GF  +     C+D+DEC         G C NT GSF C C 
Sbjct: 888  GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCY 947

Query: 305  AGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCP---RGYV---------TS 352
             G +  +  Q C D++EC ++ G+C    C N  GS+ CVC    + Y          TS
Sbjct: 948  QGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTS 1007

Query: 353  TDGSRCIDQ---RTGMCFSGLVNGR-CAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVR 408
            TD    +DQ       C+  L +   C   L   +TK +CCC  G  WG       CPV 
Sbjct: 1008 TDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVL 1067

Query: 409  GSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFS 468
            G+ E+  +C                                   P G GF+P        
Sbjct: 1068 GTAEFTEMC-----------------------------------PKGKGFVP-------- 1084

Query: 469  PGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMG-YKQ 527
               G +   AGG+              +       +C NG C+ T   Y C C  G Y  
Sbjct: 1085 --AGESSSEAGGEN--------YKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYD 1134

Query: 528  DANGDCIDVDECTS-NPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACI---DIDECIQNG 583
                 C D+DEC   + C +G CVNT GSY C C        +++ CI   + +E I+  
Sbjct: 1135 PVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEET 1194

Query: 584  VLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCIC 643
             + ++    +    + C      + TT  + C  + E       L  +  ++D +  C  
Sbjct: 1195 DVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNI 1254

Query: 644  KPGFVLAPNGR---------YCTDVD------------------ECQTPGICMNGHCINS 676
                   P GR         Y  + D                  EC     C NG C+  
Sbjct: 1255 PVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRV 1314

Query: 677  EGSFRCDCPPGLAVGMDGRVCVDTH 701
            +  + CDC  G  +      CVD +
Sbjct: 1315 QEGYTCDCFDGYHLDTAKMTCVDVN 1339



 Score =  152 bits (383), Expect = 6e-36
 Identities = 144/559 (25%), Positives = 204/559 (36%), Gaps = 119/559 (21%)

Query: 86   PNVCGSR---------FHSYCCPGWKTLPGGNQCI-VPICRNSCGDGFCSRPNMCTCSSG 135
            P +CG +         FH  C  G+     G  C  +  C N+     C     C  ++G
Sbjct: 884  PGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNT---VCDSHGFCDNTAG 940

Query: 136  QISSTCGSKSIQQCSVRCMNGGTCAD-DHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPN 194
                 C      Q      +G  C D + C+   G     CG+  CEN  +    C+  +
Sbjct: 941  SFRCLC-----YQGFQAPQDGQGCVDVNECELLSGV----CGEAFCEN-VEGSFLCVCAD 990

Query: 195  RCACVYGFTGPQCERDYRTG-------------PCFTQVNN-QMCQGQLTGIVCTKTLCC 240
                    TG QC     T               C+  +N+  +C   L   V TK  CC
Sbjct: 991  ENQEYSPMTG-QCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNV-TKQECC 1048

Query: 241  ATIGRAWGHPCEMCPA---------QPQPCRRGFIPNIRTGA------CQDVDECQAI-P 284
             T G  WG  CE+ P          +  P  +GF+P   + +       +D DEC     
Sbjct: 1049 CTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQ 1108

Query: 285  GICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCV 344
             IC+ G C+NT   +EC C  G        +C D+DEC   P  C  G+C NT GSY C 
Sbjct: 1109 EICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQ-DPSSCIDGQCVNTEGSYNCF 1167

Query: 345  CPRGYVTSTDGSRCI------------DQRTGMCFSGLVNGR-CAQELPGRMTK-MQCCC 390
            C    V      RCI            D    +C+  L +   C++ L G+ T   +CCC
Sbjct: 1168 CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCC 1227

Query: 391  EPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNG 450
              G  WG+      CP++ S++Y +LC        IP +   +P G      A       
Sbjct: 1228 LYGEAWGMQC--ALCPLKDSDDYAQLC-------NIPVTGRRQPYGRD----ALVDFSEQ 1274

Query: 451  YGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANL---CLN 507
            Y P                             P       LN   ++      +   C N
Sbjct: 1275 YTPEA--------------------------DPYFIQDRFLNSFEELQAEECGILNGCEN 1308

Query: 508  GRCIPTVSSYRCECNMGYKQD-ANGDCIDVDECTS-----NPCTNGDCVNTPGSYYCKCH 561
            GRC+     Y C+C  GY  D A   C+DV+EC       + C N  C+NT GSY C C 
Sbjct: 1309 GRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCL 1368

Query: 562  AGFQRTPTKQACIDIDECI 580
             G+  +     C  ++  +
Sbjct: 1369 PGYVPSDKPNYCTPLNTAL 1387



 Score =  132 bits (333), Expect = 4e-30
 Identities = 69/202 (34%), Positives = 103/202 (50%), Gaps = 19/202 (9%)

Query: 896  GTCWLNIQDSRCEVNINGATLKSECCATLGAAWG-SPCERCELDTA---------CPRGL 945
            G C+     S+C   + G + + +CC T+G +WG + C++C    +         C  G 
Sbjct: 231  GRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGY 290

Query: 946  ARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLD----IRME 1001
             R+    C+D+NEC++  GVCPNG C+N+ GS+ C C  G   D T   C+     I  E
Sbjct: 291  KRVNNTFCQDINECQL-QGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEE 349

Query: 1002 Q--CY-LKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGF 1058
            +  CY L     +C+HP+        CCC+VG AWG  CE+CP PGT  ++ +CP G G+
Sbjct: 350  KGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGY 409

Query: 1059 ANRGDVLTGRPFYKDINECKAF 1080
               G V   RP +  + +   F
Sbjct: 410  TVSG-VHRRRPIHHHVGKGPVF 430



 Score =  108 bits (269), Expect = 1e-22
 Identities = 57/134 (42%), Positives = 73/134 (54%), Gaps = 9/134 (6%)

Query: 2320 MCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTEC- 2378
            M  C PG  +R +   C D NEC+ + G+C NG C+N +GSYRC C  GF    + + C 
Sbjct: 283  MMECLPGY-KRVNNTFCQDINECQLQ-GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 340

Query: 2379 -----LDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQY 2433
                 +   +G C+  V      M   S +L TK  CCC  G+ WG  CE CPLPGTA +
Sbjct: 341  PDPPVISEEKGPCYRLVSSGRQCMHPLSVHL-TKQLCCCSVGKAWGPHCEKCPLPGTAAF 399

Query: 2434 KKICPHGPGYTTDG 2447
            K+ICP G GYT  G
Sbjct: 400  KEICPGGMGYTVSG 413



 Score =  101 bits (252), Expect = 9e-21
 Identities = 67/202 (33%), Positives = 93/202 (46%), Gaps = 49/202 (24%)

Query: 1603 RSSCCCSLGKAWG-NPCETCPPVNSTEYYT----LCPGGEGFRPNPITIILEDIDECQEL 1657
            +  CC ++G +WG N C+ CP   S   Y       PG +  R N      +DI+ECQ L
Sbjct: 252  QEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYK--RVN--NTFCQDINECQ-L 306

Query: 1658 PGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTC 1717
             G+C  G C+NT GS++C C  G+                      GP   ++     +C
Sbjct: 307  QGVCPNGECLNTMGSYRCTCKIGF----------------------GPDPTFS-----SC 339

Query: 1718 ICPPEYMQVNGGHNCMDMRKSFCYRSY-NGTTCENELPFNVTKRMCCCTYNVGKAWNKPC 1776
            +  P  +    G          CYR   +G  C + L  ++TK++CCC  +VGKAW   C
Sbjct: 340  VPDPPVISEEKGP---------CYRLVSSGRQCMHPLSVHLTKQLCCC--SVGKAWGPHC 388

Query: 1777 EPCPTPGTADFKTICGNIPGFT 1798
            E CP PGTA FK IC    G+T
Sbjct: 389  EKCPLPGTAAFKEICPGGMGYT 410



 Score = 96.3 bits (238), Expect = 4e-19
 Identities = 58/218 (26%), Positives = 87/218 (39%), Gaps = 51/218 (23%)

Query: 214 GPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWG-HPCEMCPAQPQ--------PCRRG 264
           G CF +     C   L G+   +  CC T+G +WG + C+ CP +P          C  G
Sbjct: 231 GRCFQETIGSQCGKALPGLSKQED-CCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPG 289

Query: 265 FIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSI 324
           +   +    CQD++ECQ + G+C  G C+NT+GS+ C C  G     T   C        
Sbjct: 290 Y-KRVNNTFCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC-------- 339

Query: 325 IPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGR-CAQELPGRM 383
                                             I +  G C+  + +GR C   L   +
Sbjct: 340 ----------------------------VPDPPVISEEKGPCYRLVSSGRQCMHPLSVHL 371

Query: 384 TKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGL 421
           TK  CCC  G+ WG     E CP+ G+  ++ +C  G+
Sbjct: 372 TKQLCCCSVGKAWGPHC--EKCPLPGTAAFKEICPGGM 407



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 45/130 (34%), Positives = 64/130 (49%), Gaps = 8/130 (6%)

Query: 643 CKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVD--- 699
           C PG+    N  +C D++ECQ  G+C NG C+N+ GS+RC C  G         CV    
Sbjct: 286 CLPGYKRV-NNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 344

Query: 700 --THMRSTCYGGIKKG-VCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 756
             +  +  CY  +  G  C+ P    +TK  CCC +    +G  C+ CP   +A F  +C
Sbjct: 345 VISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 403

Query: 757 SSGVGITVDG 766
             G+G TV G
Sbjct: 404 PGGMGYTVSG 413



 Score = 86.7 bits (213), Expect = 3e-16
 Identities = 67/200 (33%), Positives = 88/200 (44%), Gaps = 30/200 (15%)

Query: 1988 GRCFNE-IGSFKCLCNEGYELTPDGKNCIDT-------NECVALPGSCS-PGTCQNLEGS 2038
            GRCF E IGS    C +        ++C  T       N+C   P   S  G  Q +E  
Sbjct: 231  GRCFQETIGS---QCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMME-- 285

Query: 2039 FRCICPPGYE-VKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRC- 2096
                C PGY+ V +  C DINEC     +C  G C NT G ++C C  GF        C 
Sbjct: 286  ----CLPGYKRVNNTFCQDINECQLQ-GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 340

Query: 2097 -----FDTRQSFCFTNFENGK-CSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVA 2150
                     +  C+    +G+ C  P + + TK  CCCS   G+ WG  CE CP     A
Sbjct: 341  PDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSV--GKAWGPHCEKCPLPGTAA 398

Query: 2151 FQDLCPYGHG-TVPSLHDTR 2169
            F+++CP G G TV  +H  R
Sbjct: 399  FKEICPGGMGYTVSGVHRRR 418



 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 43/116 (37%), Positives = 56/116 (48%), Gaps = 10/116 (8%)

Query: 1530 CTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDN------RVGNCYLKF 1583
            C DI+EC     C NG C+NT G Y C C   F  +PT   CV +        G CY   
Sbjct: 298  CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLV 357

Query: 1584 GPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGF 1639
                     C   + V +++  CCCS+GKAWG  CE CP   +  +  +CPGG G+
Sbjct: 358  S----SGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGY 409



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 46/126 (36%), Positives = 69/126 (54%), Gaps = 10/126 (7%)

Query: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWG-HQCELCPL-PGTAQYKKICPHGP 2441
            G CF E + + C  A     L  + +CC   G  WG ++C+ CP  P    Y ++    P
Sbjct: 231  GRCFQETIGSQCGKALPG--LSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLP 288

Query: 2442 GY----TTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCI-DLDECS 2496
            GY     T  +DI+EC++   +C NG+C+NTMGS+RC CK+G+  D + +SC+ D    S
Sbjct: 289  GYKRVNNTFCQDINECQLQ-GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVIS 347

Query: 2497 QSPKPC 2502
            +   PC
Sbjct: 348  EEKGPC 353



 Score = 75.5 bits (184), Expect = 7e-13
 Identities = 49/174 (28%), Positives = 78/174 (44%), Gaps = 13/174 (7%)

Query: 945  LARIKGVTCEDVNECEVFPG---VCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRME 1001
            ++RI G T +   E +  PG   V   G  V    + H        +     V    ++ 
Sbjct: 174  VSRIDGPTGQKTKEAQ--PGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLG 231

Query: 1002 QCYLKWDEDECIHPVPGKFRMDACCCAVGAAWG-TECEECPK-PGTKEYETLCPRGAGFA 1059
            +C+ +    +C   +PG  + + CC  VG +WG  +C++CPK P    Y  +     G+ 
Sbjct: 232  RCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYK 291

Query: 1060 NRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNC 1113
                      F +DINEC+   G+C  G+C NT+GS++C C  GF  D    +C
Sbjct: 292  R-----VNNTFCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 62/239 (25%), Positives = 83/239 (34%), Gaps = 81/239 (33%)

Query: 715 CVRPFPGAVTKSECC-CANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECA 773
           C +  PG   + +CC      +GF + CQ CP K S  +HG                   
Sbjct: 242 CGKALPGLSKQEDCCGTVGTSWGFNK-CQKCPKKPS--YHGY------------------ 280

Query: 774 LDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSY 833
                  N + E L G  R N             C DI+EC +  + C NG C NT GSY
Sbjct: 281 -------NQMMECLPGYKRVN----------NTFCQDINECQLQGV-CPNGECLNTMGSY 322

Query: 834 SCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDS 893
            CTC  G+            + C  +P V                            I  
Sbjct: 323 RCTCKIGF------GPDPTFSSCVPDPPV----------------------------ISE 348

Query: 894 LKGTCWLNIQDSR-CEVNINGATLKSECCATLGAAWGSPCERCEL------DTACPRGL 945
            KG C+  +   R C   ++    K  CC ++G AWG  CE+C L         CP G+
Sbjct: 349 EKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGM 407



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 4/110 (3%)

Query: 1740 CYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPT-PGTADFKTICGNIPGFT 1798
            C++   G+ C   LP    +  CC T      +NK C+ CP  P    +  +   +PG+ 
Sbjct: 233  CFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNK-CQKCPKKPSYHGYNQMMECLPGYK 291

Query: 1799 FDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVC 1848
              ++     DI+EC ++ G+C NG C+N +GS+RC C  GF  +     C
Sbjct: 292  -RVNNTFCQDINEC-QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 52/201 (25%), Positives = 74/201 (36%), Gaps = 54/201 (26%)

Query: 520 ECNMGYKQDANGDCIDVDECT-SNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDE 578
           EC  GYK+  N  C D++EC     C NG+C+NT GSY C C  GF   PT  +C+    
Sbjct: 285 ECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 344

Query: 579 CIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGS 638
            I      + G C              + L + G+ C+       T              
Sbjct: 345 VISE----EKGPC--------------YRLVSSGRQCMHPLSVHLTKQL----------- 375

Query: 639 FKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCV 698
             C C  G    P+       ++C  PG            +F+  CP G+   + G    
Sbjct: 376 --CCCSVGKAWGPH------CEKCPLPG----------TAAFKEICPGGMGYTVSG---- 413

Query: 699 DTHMRSTCYGGIKKG-VCVRP 718
             H R   +  + KG V V+P
Sbjct: 414 -VHRRRPIHHHVGKGPVFVKP 433



 Score = 58.9 bits (141), Expect = 7e-08
 Identities = 49/168 (29%), Positives = 69/168 (41%), Gaps = 28/168 (16%)

Query: 109 QCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQK 168
           +C      + CG           C  G + ++ G    Q+C  +    G   +   +C  
Sbjct: 232 RCFQETIGSQCGKALPGLSKQEDCC-GTVGTSWGFNKCQKCPKKPSYHGY--NQMMECLP 288

Query: 169 GYI---GTYCG-------QPVCENG-CQNGGRCIGPNRCACVYGF----TGPQCERD--- 210
           GY     T+C        Q VC NG C N    +G  RC C  GF    T   C  D   
Sbjct: 289 GYKRVNNTFCQDINECQLQGVCPNGECLN---TMGSYRCTCKIGFGPDPTFSSCVPDPPV 345

Query: 211 --YRTGPCFTQVNN-QMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCP 255
                GPC+  V++ + C   L+ +  TK LCC ++G+AWG  CE CP
Sbjct: 346 ISEEKGPCYRLVSSGRQCMHPLS-VHLTKQLCCCSVGKAWGPHCEKCP 392



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 25/56 (44%), Positives = 28/56 (50%), Gaps = 1/56 (1%)

Query: 2652 CVDENECSNPNACGSASCYNTLGSYKCACPSGFSFD-QFSSACHDVNECSSSKNPC 2706
            C D NEC     C +  C NT+GSY+C C  GF  D  FSS   D    S  K PC
Sbjct: 298  CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 353



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 63/245 (25%), Positives = 86/245 (35%), Gaps = 69/245 (28%)

Query: 2099 TRQSFCFTNFENGKCSVPKAF-NTTKAKCCCSKMPGEGWG-DPCELCPKDDEVAFQDLCP 2156
            T+   CF      +C   KA    +K + CC  + G  WG + C+ CPK           
Sbjct: 228  TQLGRCFQETIGSQCG--KALPGLSKQEDCCGTV-GTSWGFNKCQKCPKK---------- 274

Query: 2157 YGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDE 2216
                  PS H   + +                        EC  GY        C D +E
Sbjct: 275  ------PSYHGYNQMM------------------------ECLPGYKR-VNNTFCQDINE 303

Query: 2217 CSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFR---CMNTFG 2273
            C +   C NG C N +GS+ C C  GF P P       + C  +P + +     C     
Sbjct: 304  CQLQGVCPNGECLNTMGSYRCTCKIGFGPDP-----TFSSCVPDPPVISEEKGPCYRLVS 358

Query: 2274 S-YECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKN--LIGT--FMCICPPGMA 2328
            S  +C  P+   L       K L  C+ G    ++ G  C+   L GT  F  ICP GM 
Sbjct: 359  SGRQCMHPLSVHL------TKQLCCCSVG----KAWGPHCEKCPLPGTAAFKEICPGGMG 408

Query: 2329 RRPDG 2333
                G
Sbjct: 409  YTVSG 413



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 32/94 (34%), Positives = 44/94 (46%), Gaps = 11/94 (11%)

Query: 1857 GDNLCQRNADCINSPGSY----RCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQ 1912
            G N CQ+   C   P  +      EC  G+K   N  C D NEC ++  VC +G C++  
Sbjct: 264  GFNKCQK---CPKKPSYHGYNQMMECLPGYKRVNNTFCQDINEC-QLQGVCPNGECLNTM 319

Query: 1913 GSYQCICHNGFKASQDQTMCM---DVDECERHPC 1943
            GSY+C C  GF      + C+    V   E+ PC
Sbjct: 320  GSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 353



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 20/43 (46%), Positives = 27/43 (62%), Gaps = 1/43 (2%)

Query: 1447 CSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSC 1489
            C D++EC     +C NG+CLN  G+YRC C++GF P     SC
Sbjct: 298  CQDINECQLQ-GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339



 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 39/135 (28%), Positives = 58/135 (42%), Gaps = 27/135 (20%)

Query: 1067 GRPFYKDI-NEC-KAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPD 1124
            GR F + I ++C KA PG+     C  T+G+     + GF             +C   P 
Sbjct: 231  GRCFQETIGSQCGKALPGLSKQEDCCGTVGT-----SWGF---------NKCQKCPKKPS 276

Query: 1125 LCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCD 1184
              G    +        EC  GY+   +    C DI+EC+   + C  G C+NT GS++C 
Sbjct: 277  YHGYNQMM--------ECLPGYKR--VNNTFCQDINECQLQGV-CPNGECLNTMGSYRCT 325

Query: 1185 CPLGHELSPSREDCV 1199
            C +G    P+   CV
Sbjct: 326  CKIGFGPDPTFSSCV 340



 Score = 46.2 bits (108), Expect = 5e-04
 Identities = 39/139 (28%), Positives = 59/139 (42%), Gaps = 29/139 (20%)

Query: 1919 CHNGFKASQDQTMCMDVDECE-RHPCGNGTCKNTVGSYNCLCYPGF--ELTHNNDCLD-- 1973
            C  G+K   + T C D++EC+ +  C NG C NT+GSY C C  GF  + T ++   D  
Sbjct: 286  CLPGYKRVNN-TFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 344

Query: 1974 --IDECSSFFGQVCRNGRCFNEIG----SFKCLCNEGYELTPDGKNCIDTNECVALPGSC 2027
               +E    +  V    +C + +        C C+ G    P  + C        LPG+ 
Sbjct: 345  VISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKC-------PLPGT- 396

Query: 2028 SPGTCQNLEGSFRCICPPG 2046
                      +F+ ICP G
Sbjct: 397  ---------AAFKEICPGG 406



 Score = 45.4 bits (106), Expect = 8e-04
 Identities = 40/141 (28%), Positives = 59/141 (41%), Gaps = 34/141 (24%)

Query: 1813 KEIPGICANGVCINQIGSF----RCE-CPTGFSY---NDLL-----------LVCEDIDE 1853
            K +PG+     C   +G+     +C+ CP   SY   N ++             C+DI+E
Sbjct: 244  KALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINE 303

Query: 1854 CSNGDNLCQRNADCINSPGSYRCECAAGFKLSPN-GACV--------DRNECLEIPN--- 1901
            C     +C  N +C+N+ GSYRC C  GF   P   +CV        ++  C  + +   
Sbjct: 304  CQL-QGVCP-NGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGR 361

Query: 1902 VCSHGLCVDLQGSYQCICHNG 1922
             C H L V L     C C  G
Sbjct: 362  QCMHPLSVHLT-KQLCCCSVG 381



 Score = 45.4 bits (106), Expect = 8e-04
 Identities = 28/91 (30%), Positives = 40/91 (43%), Gaps = 7/91 (7%)

Query: 1195 REDCVDINECSLSDNLCRNGKCVNMIGTY----QCSCNPGYQATPDRQGCTDIDECMIMN 1250
            +EDC      S   N C+  KC      +       C PGY+   +   C DI+EC +  
Sbjct: 252  QEDCCGTVGTSWGFNKCQ--KCPKKPSYHGYNQMMECLPGYKRV-NNTFCQDINECQLQG 308

Query: 1251 GGCDTQCTNSEGSYECSCSEGYALMPDGRSC 1281
               + +C N+ GSY C+C  G+   P   SC
Sbjct: 309  VCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 36/134 (26%), Positives = 51/134 (38%), Gaps = 15/134 (11%)

Query: 2557 KCPPGFTQ-HHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNC--- 2612
            +C PG+ + ++T C D NEC  Q  +C   G C NT GS+ C C+ GF  D T  +C   
Sbjct: 285  ECLPGYKRVNNTFCQDINECQLQ-GVC-PNGECLNTMGSYRCTCKIGFGPDPTFSSCVPD 342

Query: 2613 -----EDVDEC----DGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNA 2663
                 E+   C        +C H     L    C C  G        +C      +    
Sbjct: 343  PPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEI 402

Query: 2664 CGSASCYNTLGSYK 2677
            C     Y   G ++
Sbjct: 403  CPGGMGYTVSGVHR 416



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 18/43 (41%), Positives = 25/43 (58%), Gaps = 1/43 (2%)

Query: 1323 CIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGC 1365
            C D+NEC L   +C  GEC NT GS+ C C++G+      + C
Sbjct: 298  CQDINECQLQG-VCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339



 Score = 43.1 bits (100), Expect = 0.004
 Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 2/57 (3%)

Query: 1268 CSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCI 1324
            C  GY  + +   C DI+EC+    +C  G+C N  G YRC C  GF       +C+
Sbjct: 286  CLPGYKRV-NNTFCQDINECQLQ-GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 340



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 44/172 (25%), Positives = 65/172 (37%), Gaps = 31/172 (18%)

Query: 2454 KVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSY 2513
            K +P L     C  T+G+   F K                 C + PK  +Y   N     
Sbjct: 244  KALPGLSKQEDCCGTVGTSWGFNK-----------------CQKCPKKPSYHGYNQ---- 282

Query: 2514 QCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHT--ACID 2571
               C  GY  + +   C+D++ECQ +       C+NT+G + C C  GF    T  +C+ 
Sbjct: 283  MMECLPGYK-RVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVP 341

Query: 2572 NNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDAT-GLNCEDVDECDGNH 2622
            +      P +   KG C     S   +C    S+  T  L C  V +  G H
Sbjct: 342  D-----PPVISEEKGPCYRLVSS-GRQCMHPLSVHLTKQLCCCSVGKAWGPH 387



 Score = 41.2 bits (95), Expect = 0.015
 Identities = 34/123 (27%), Positives = 48/123 (39%), Gaps = 14/123 (11%)

Query: 1402 NGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDV-------DECA 1454
            N   C D++EC         N +C+NT GSYRC C  GF  D    S V       +E  
Sbjct: 294  NNTFCQDINECQ--LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKG 351

Query: 1455 ENINLCENG-QCLNVPGAY----RCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNL 1509
                L  +G QC++    +     C C +G         C      +F+ IC  G    +
Sbjct: 352  PCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTV 411

Query: 1510 PGM 1512
             G+
Sbjct: 412  SGV 414



 Score = 40.8 bits (94), Expect = 0.020
 Identities = 23/73 (31%), Positives = 32/73 (43%), Gaps = 6/73 (8%)

Query: 110 CIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQ--CSVRCMNGGTCAD-DHCQC 166
           C    C+NSC  G           +G  + T  + + +   C + CMNGG C+  D CQC
Sbjct: 39  CTKGSCQNSCEKG---NTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQC 95

Query: 167 QKGYIGTYCGQPV 179
              + G  C  PV
Sbjct: 96  PPNFTGKLCQIPV 108



 Score = 38.5 bits (88), Expect = 0.098
 Identities = 62/290 (21%), Positives = 93/290 (32%), Gaps = 64/290 (22%)

Query: 158 TCADDHCQ--CQKGYIGTYCGQP---------------VCENGCQNGGRCIGPNRCACVY 200
           TC    CQ  C+KG   T   +                +C   C NGG+C   ++C C  
Sbjct: 38  TCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCP- 96

Query: 201 GFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATI-GRAWG-------HPCE 252
                         P FT    ++CQ  + G    K    +   G+A G       H   
Sbjct: 97  --------------PNFT---GKLCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLP 139

Query: 253 MCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSET 312
           +     Q  +  F PNI     +   E             I+ V   +   P G K  E 
Sbjct: 140 LTVTSQQGVKVKFPPNIVNIHVKHPPEASVQ---------IHQVSRIDG--PTGQKTKEA 188

Query: 313 TQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVN 372
                 +    +     +T    ++  S+  V P  Y  +         + G CF   + 
Sbjct: 189 QPGQSQVSYQGLPVQKTQT---IHSTYSHQQVIPHVYPVAAK------TQLGRCFQETIG 239

Query: 373 GRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLP 422
            +C + LPG   +  CC   G  WG     + CP + S       M+ LP
Sbjct: 240 SQCGKALPGLSKQEDCCGTVGTSWGFNKC-QKCPKKPSYHGYNQMMECLP 288



 Score = 35.8 bits (81), Expect = 0.64
 Identities = 16/48 (33%), Positives = 27/48 (56%), Gaps = 3/48 (6%)

Query: 1352 CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW 1399
            C  GY  +   T C D++EC++       +  CLN  GS++C+C+ G+
Sbjct: 286  CLPGYK-RVNNTFCQDINECQL--QGVCPNGECLNTMGSYRCTCKIGF 330



 Score = 35.8 bits (81), Expect = 0.64
 Identities = 15/36 (41%), Positives = 22/36 (61%), Gaps = 1/36 (2%)

Query: 493 QTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQD 528
           Q I+ C+    +C NG C+ T+ SYRC C +G+  D
Sbjct: 299 QDINECQLQG-VCPNGECLNTMGSYRCTCKIGFGPD 333



 Score = 34.7 bits (78), Expect = 1.4
 Identities = 24/74 (32%), Positives = 33/74 (44%), Gaps = 12/74 (16%)

Query: 2498 SPKPCNYICKNTEGSYQCSCPRGY---VLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGF 2554
            +P  C   C  T+GS Q SC +G    ++ E+G     L     +   C   C+N  GG 
Sbjct: 31   TPSICKVTC--TKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMN--GGQ 86

Query: 2555 T-----CKCPPGFT 2563
                  C+CPP FT
Sbjct: 87   CSSRDKCQCPPNFT 100



 Score = 33.1 bits (74), Expect = 4.1
 Identities = 14/33 (42%), Positives = 16/33 (48%)

Query: 2693 CHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGY 2725
            C D+NEC       N  C NT G Y C C  G+
Sbjct: 298  CQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 330


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  461 bits (1186), Expect = e-129
 Identities = 486/1731 (28%), Positives = 675/1731 (38%), Gaps = 426/1731 (24%)

Query: 1087 GKCRNTI----GSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECEC 1142
            G C++++      F CRC  GF       +C+  D C  SP   G+   V   G F C C
Sbjct: 91   GVCQSSVVAGTARFSCRCPRGF----RGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSC 146

Query: 1143 FEGYESGFMMMKNCM-DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDI 1201
              GY+      ++C  D+DEC        GGTC+NT GSF+C CP G+         V  
Sbjct: 147  PPGYQG-----RSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVP- 200

Query: 1202 NECSLSDNLCRNGKCVNMIG--TYQCSCNPGYQATPDRQGC-TDIDEC---MIMNGGCDT 1255
              C+ S   CRNG      G  TY C+C PG++     Q C  ++D+C     +NGG   
Sbjct: 201  --CAPSP--CRNGGTCRQSGDLTYDCACLPGFEG----QNCEVNVDDCPGHRCLNGGT-- 250

Query: 1256 QCTNSEGSYECSCSEGYALMPDGRSCA-DIDECENNPDIC-DGGQCTNIPGEYRCLCYDG 1313
             C +   +Y C C   +     G+ C  D+DEC+  P+ C +GG C N  G + C+C +G
Sbjct: 251  -CVDGVNTYNCQCPPEWT----GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNG 305

Query: 1314 FMASMDMKTCIDVNECDLNSNICMFGE-CENTKGSFICHCQLGYSVKKGTTGCTDVDECE 1372
            +      ++C   N  D  + +C  G  C +   SF C C +G   K G   C   D C 
Sbjct: 306  WTG----ESCSQ-NIDDCATAVCFHGATCHDRVASFYCACPMG---KTGLL-CHLDDACV 356

Query: 1373 IGAHNCDMHASCLNIP--GSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPG 1430
              ++ C   A C   P  G   C+C  G+ G G    D+DECS G + C    +CVNT G
Sbjct: 357  --SNPCHEDAICDTNPVNGRAICTCPPGFTG-GACDQDVDECSIGANPCEHLGRCVNTQG 413

Query: 1431 SYRCACSEGFTGDGFTCSDVDECAENINLCEN-GQCLNVPGAYRCECEMGFTPASDSRSC 1489
            S+ C C  G+TG     +DV+EC      C N   CL+  G + C C  GFT       C
Sbjct: 414  SFLCQCGRGYTGPRCE-TDVNECLS--GPCRNQATCLDRIGQFTCICMAGFT----GTYC 466

Query: 1490 Q-DIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNC-TDIDECADPINCVNGL- 1546
            + DIDEC        G C +    F C C  G+    +G  C  D+DECA    C NG  
Sbjct: 467  EVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGF----SGSTCQLDVDECAS-TPCRNGAK 521

Query: 1547 CVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSC 1606
            CV+ P  YEC C   F+    G  C D  V +C     P       C      G++  SC
Sbjct: 522  CVDQPDGYECRCAEGFE----GTLC-DRNVDDC----SPDPCHHGRCVD----GIASFSC 568

Query: 1607 CCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQ-GGN 1665
             C+ G   G  CE+                              +DEC+  P  C+ GG 
Sbjct: 569  ACAPGYT-GTRCES-----------------------------QVDECRSQP--CRHGGK 596

Query: 1666 CINTFGSFQCECPQGYYLSEDTRI-CE-DIDECFAHPGVCGPGTCYNTLGNYTCICPPEY 1723
            C++    + C CP G      T + CE +ID+C ++P  C  G C + +  Y C+C P +
Sbjct: 597  CLDLVDKYLCRCPSG-----TTGVNCEVNIDDCASNP--CTFGVCRDGINRYDCVCQPGF 649

Query: 1724 ------MQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPC- 1776
                  +++N   +        C    NG  C    P      +C          + PC 
Sbjct: 650  TGPLCNVEINECASSPCGEGGSCVDGENGFRC--LCPPGSLPPLCLPP-------SHPCA 700

Query: 1777 -EPC------PTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIG 1829
             EPC        PG   F+ +C   PG++      +++  D C+  P   A G C +   
Sbjct: 701  HEPCSHGICYDAPG--GFRCVCE--PGWS-GPRCSQSLARDACESQP-CRAGGTCSSDGM 754

Query: 1830 SFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYR-CECAAGFKLSPNG 1888
             F C CP G         CE +  C+   N C+    C ++PG    C C  G++  P  
Sbjct: 755  GFHCTCPPGVQGRQ----CELLSPCT--PNPCEHGGRCESAPGQLPVCSCPQGWQ-GPR- 806

Query: 1889 ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKA-SQDQTMCMDVDECERHPCGN-G 1946
               D +EC        HG+C +L GS+ C CH G+   S DQ    D+++C+ +PC N G
Sbjct: 807  CQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQ----DINDCDPNPCLNGG 862

Query: 1947 TCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYE 2006
            +C++ VGS++C C PGF         D+DEC S     C  G C + + SF C C  GY 
Sbjct: 863  SCQDGVGSFSCSCLPGF--AGPRCARDVDECLS---NPCGPGTCTDHVASFTCTCPPGY- 916

Query: 2007 LTPDGKNC-IDTNECVALPGSC-SPGTCQNLEGSFRCICPPGYEVKSENC-IDINECDED 2063
                G +C  D  +C   P SC + GTC +   SF C+C PGY     +C  + + C   
Sbjct: 917  ---GGFHCEQDLPDC--SPSSCFNGGTCVDGVNSFSCLCRPGY--TGAHCQHEADPCLSR 969

Query: 2064 PNICLFGS-CTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTN--FENGKCSVPKAFN 2120
            P  CL G  C+    GF+C C   F     G +C  T   +C        G+C       
Sbjct: 970  P--CLHGGVCSAAHPGFRCTCLESF----TGPQC-QTLVDWCSRQPCQNGGRCV------ 1016

Query: 2121 TTKAKCCCSKMPGEGWGD--------PCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDV 2172
             T A C C      GW          PC        V  + LC  G              
Sbjct: 1017 QTGAYCLCP----PGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAG-------------- 1058

Query: 2173 NECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGN-GTCTNV 2231
                        GQC++ D S  C CP G     TG  C    +  +  PC + GTC   
Sbjct: 1059 ------------GQCVDEDSSHYCVCPEG----RTGSHCEQEVDPCLAQPCQHGGTCRGY 1102

Query: 2232 IGSFECNCNEGFEPGPMMNCE-DINECAQNPLLCAFRCMNTFGSYECTCP---IGYALRE 2287
            +G + C C  G+      NCE D++ECA  P      C++    Y C+CP   +G     
Sbjct: 1103 MGGYMCECLPGYNGD---NCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEI 1159

Query: 2288 DQKMC---KDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECR 2343
            ++  C     LD     LH+       C +L+G F C CPPG      G  C  D NECR
Sbjct: 1160 NEDDCGPGPPLDSGPRCLHN-----GTCVDLVGGFRCTCPPGYT----GLRCEADINECR 1210

Query: 2344 TKPGICENGRCVNII----GSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMAS 2399
            +  G C      + +    G +RC C+ GF    SG  C             QT+     
Sbjct: 1211 S--GACHAAHTRDCLQDPGGGFRCLCHAGF----SGPRC-------------QTVLSPC- 1250

Query: 2400 SSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNL 2459
                   +S+ C  GG     QC   P PG                              
Sbjct: 1251 -------ESQPCQHGG-----QCRPSPGPGGGL--------------------------- 1271

Query: 2460 CTNGQCINTMGSFRCFCKVGYTTDISGTSCIDL-DECSQSPKPCNYICKNTEGSYQCSCP 2518
                       +F C C   +     G  C  +   C +   P    C+ T    +C+CP
Sbjct: 1272 -----------TFTCHCAQPFW----GPRCERVARSCRELQCPVGVPCQQTPRGPRCACP 1316

Query: 2519 RGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQ 2578
             G      G +C+                           PPG          N  C + 
Sbjct: 1317 PGL----SGPSCRSFP----------------------GSPPG--------ASNASCAAA 1342

Query: 2579 PSLCGAKGICQNTPGS--FSCECQRGFSLDATGLNCE---DVDECDGNHRC-QHGCQNIL 2632
            P L G  G C+  P +  F C C +G+    TG  CE      E     RC +  CQ   
Sbjct: 1343 PCLHG--GSCRPAPLAPFFRCACAQGW----TGPRCEAPAAAPEVSEEPRCPRAACQAKR 1396

Query: 2633 GGYRC-------GCPQGYIQHYQWNQCVDENECS----NP-NACGSASCYNTLGSYKC-- 2678
            G  RC       GC         W    D  +CS    +P   C +  C+    + +C  
Sbjct: 1397 GDQRCDRECNSPGC--------GW----DGGDCSLSVGDPWRQCEALQCWRLFNNSRCDP 1444

Query: 2679 ACPS-GFSFDQF-------SSACHDVNE--CSS--SKNPCNYGCSNTEGGY 2717
            AC S    +D F          C+ V E  C+   +   C+ GC+  E G+
Sbjct: 1445 ACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGW 1495



 Score =  431 bits (1107), Expect = e-120
 Identities = 410/1387 (29%), Positives = 563/1387 (40%), Gaps = 299/1387 (21%)

Query: 1406 CIDLDECSNGTHQCSINAQCVNTPG-SYRCACSEGFTGDGFTCSDVDECAENINLCENGQ 1464
            C+D   C+NG        +C   P     C C  G+ G+   C   D C         G 
Sbjct: 43   CLDGSPCANG-------GRCTQLPSREAACLCPPGWVGE--RCQLEDPCHSG-PCAGRGV 92

Query: 1465 CLN--VPGAYR--CECEMGFTPASDSRSCQDIDECSFQNICVFGT-CNNLP-GMFHCICD 1518
            C +  V G  R  C C  GF        C   D C   + C  G  C+  P G F C C 
Sbjct: 93   CQSSVVAGTARFSCRCPRGFR----GPDCSLPDPC-LSSPCAHGARCSVGPDGRFLCSCP 147

Query: 1519 DGYELDRTGGNC-TDIDECADPINCVNG-LCVNTPGRYECNCPPDFQLNPTGVGCVDNRV 1576
             GY+    G +C +D+DEC     C +G  C+NTPG + C CP  +    TG  C +  V
Sbjct: 148  PGYQ----GRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGY----TGPLCENPAV 199

Query: 1577 GNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCE---TCPPVNSTEYYTLC 1633
                                         C  S       PC    TC       Y   C
Sbjct: 200  ----------------------------PCAPS-------PCRNGGTCRQSGDLTYDCAC 224

Query: 1634 -PGGEGFRPNPITIILEDIDECQELPG--LCQGGNCINTFGSFQCECPQGYYLSEDTRIC 1690
             PG EG           ++D+C   PG     GG C++   ++ C+CP  +      + C
Sbjct: 225  LPGFEGQNCEV------NVDDC---PGHRCLNGGTCVDGVNTYNCQCPPEW----TGQFC 271

Query: 1691 -EDIDECFAHPGVC-GPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTT 1748
             ED+DEC   P  C   GTC+NTLG ++C+C   +   +   N  D   + C+   +G T
Sbjct: 272  TEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCF---HGAT 328

Query: 1749 CENEL-------PFNVTKRMC----CCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGF 1797
            C + +       P   T  +C     C  N     +  C+  P  G A    IC   PGF
Sbjct: 329  CHDRVASFYCACPMGKTGLLCHLDDACVSNPCHE-DAICDTNPVNGRA----ICTCPPGF 383

Query: 1798 TFDIHTGKAVD--IDECKEIPGICAN-GVCINQIGSFRCECPTGFSYNDLLLVCE-DIDE 1853
            T     G A D  +DEC      C + G C+N  GSF C+C  G++       CE D++E
Sbjct: 384  T-----GGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPR----CETDVNE 434

Query: 1854 CSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQG 1913
            C +G   C+  A C++  G + C C AGF  +     VD +EC   P V + G+C D   
Sbjct: 435  CLSGP--CRNQATCLDRIGQFTCICMAGF--TGTYCEVDIDECQSSPCV-NGGVCKDRVN 489

Query: 1914 SYQCICHNGFKASQDQTMCMDVDECERHPCGNGT-CKNTVGSYNCLCYPGFELTHNNDCL 1972
             + C C +GF  S  Q   +DVDEC   PC NG  C +    Y C C  GFE T  +   
Sbjct: 490  GFSCTCPSGFSGSTCQ---LDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDR-- 544

Query: 1973 DIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNC-IDTNECVALPGSCSPGT 2031
            ++D+CS      C +GRC + I SF C C  GY     G  C    +EC + P     G 
Sbjct: 545  NVDDCSP---DPCHHGRCVDGIASFSCACAPGYT----GTRCESQVDECRSQPCRHG-GK 596

Query: 2032 CQNLEGSFRCICPPGYEVKSENC-IDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLS 2090
            C +L   + C CP G      NC ++I++C  +P  C FG C +    + C+C PGF   
Sbjct: 597  CLDLVDKYLCRCPSG--TTGVNCEVNIDDCASNP--CTFGVCRDGINRYDCVCQPGFT-- 650

Query: 2091 DNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVA 2150
              G  C          N E  +C+         + C        G G  C     D E  
Sbjct: 651  --GPLC----------NVEINECA--------SSPC--------GEGGSCV----DGENG 678

Query: 2151 FQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVR 2210
            F+ LCP   G++P L       + C   P  CS+G C +  G FRC C  G++    G R
Sbjct: 679  FRCLCP--PGSLPPL--CLPPSHPCAHEP--CSHGICYDAPGGFRCVCEPGWS----GPR 728

Query: 2211 CVDT---DECSIGNPC-GNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAF 2266
            C  +   D C    PC   GTC++    F C C  G +      CE ++ C  NP     
Sbjct: 729  CSQSLARDACE-SQPCRAGGTCSSDGMGFHCTCPPGVQG---RQCELLSPCTPNPCEHGG 784

Query: 2267 RCMNTFGSYE-CTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPP 2325
            RC +  G    C+CP G+   +  +  +D+DECA G   C   G+ C NL G+F C C  
Sbjct: 785  RCESAPGQLPVCSCPQGW---QGPRCQQDVDECA-GPAPCGPHGI-CTNLAGSFSCTCHG 839

Query: 2326 GMARRPDGEGC-VDENECRTKPGICENGRCVNIIGSYRCECNEGF---QSSSSGTECLDN 2381
            G      G  C  D N+C   P +   G C + +GS+ C C  GF   + +    ECL N
Sbjct: 840  GYT----GPSCDQDINDCDPNPCL-NGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSN 894

Query: 2382 RQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGP 2441
              G               +  + V    C C  G G G  CE                  
Sbjct: 895  PCG-------------PGTCTDHVASFTCTCPPGYG-GFHCE------------------ 922

Query: 2442 GYTTDGRDIDECKVMPNLCTNG-QCINTMGSFRCFCKVGYTTDISGTSCI-DLDECSQSP 2499
                  +D+ +C   P+ C NG  C++ + SF C C+ GYT    G  C  + D C   P
Sbjct: 923  ------QDLPDCS--PSSCFNGGTCVDGVNSFSCLCRPGYT----GAHCQHEADPCLSRP 970

Query: 2500 KPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDL-DECQTKQHNCQFLCVNTLGGFTCKC 2558
                 +C      ++C+C   +     G  C+ L D C  +       CV T  G  C C
Sbjct: 971  CLHGGVCSAAHPGFRCTCLESFT----GPQCQTLVDWCSRQPCQNGGRCVQT--GAYCLC 1024

Query: 2559 PPGFTQH--HTACIDNNECGSQ-----PSLCGAKGICQNTPGSFSCECQRGFSLDATGLN 2611
            PPG++        +   E  +Q       LC A G C +   S  C C  G     TG +
Sbjct: 1025 PPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG----RTGSH 1080

Query: 2612 CE-DVDECDGNHRCQHG--CQNILGGYRCGCPQGYIQHYQWNQCVDE-NECSNPNACGSA 2667
            CE +VD C     CQHG  C+  +GGY C C  GY      + C D+ +EC++       
Sbjct: 1081 CEQEVDPCLAQP-CQHGGTCRGYMGGYMCECLPGY----NGDNCEDDVDECASQPCQHGG 1135

Query: 2668 SCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNP-------C--NYGCSNTEGGYL 2718
            SC + +  Y C+CP G         C ++NE      P       C  N  C +  GG+ 
Sbjct: 1136 SCIDLVARYLCSCPPG----TLGVLC-EINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFR 1190

Query: 2719 CGCPPGY 2725
            C CPPGY
Sbjct: 1191 CTCPPGY 1197



 Score =  401 bits (1031), Expect = e-111
 Identities = 412/1545 (26%), Positives = 584/1545 (37%), Gaps = 301/1545 (19%)

Query: 645  PGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRS 704
            PG    P    C D   C   G C             C CPPG      G  C    +  
Sbjct: 36   PGAAAPP----CLDGSPCANGGRCTQ----LPSREAACLCPPGWV----GERC---QLED 80

Query: 705  TCYGG--IKKGVCVRPFPGAVTKSECCCAN----PDYGFGEPCQPCPAKNSAEFHGLCSS 758
             C+ G    +GVC         +  C C      PD    +PC   P  + A        
Sbjct: 81   PCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGAR------- 133

Query: 759  GVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNC-IDIDECLVN 817
                         C++ PD           G + C+C  GY+    GR+C  D+DEC V 
Sbjct: 134  -------------CSVGPD-----------GRFLCSCPPGYQ----GRSCRSDVDECRVG 165

Query: 818  RLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCED-INECESNPCVNGACRNNLGSFNCE 876
                  G C NTPGS+ C CP GY        CE+    C  +PC NG      G    +
Sbjct: 166  EPCRHGGTCLNTPGSFRCQCPAGYT----GPLCENPAVPCAPSPCRNGGTCRQSGDLTYD 221

Query: 877  CSPGSKLSSTGLICIDSLKG-TCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERC 935
            C+           C+   +G  C +N+ D      +NG T             G     C
Sbjct: 222  CA-----------CLPGFEGQNCEVNVDDCPGHRCLNGGTCVD----------GVNTYNC 260

Query: 936  ELDTACPRGLARIKGVTC-EDVNECEVFPGVCPN-GRCVNSKGSFHCECPEGLTLDGTGR 993
            +    CP       G  C EDV+EC++ P  C N G C N+ G   C C  G T +   +
Sbjct: 261  Q----CP---PEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQ 313

Query: 994  VCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTEC---EECPKPGTKEYET 1050
               D     C+         H     F    C C +G   G  C   + C      E + 
Sbjct: 314  NIDDCATAVCF----HGATCHDRVASF---YCACPMGKT-GLLCHLDDACVSNPCHE-DA 364

Query: 1051 LCP----RGAGFANRGDVLTGRPFYKDINECKAFPGMCTY-GKCRNTIGSFKCRCNSGFA 1105
            +C      G          TG    +D++EC      C + G+C NT GSF C+C  G+ 
Sbjct: 365  ICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYT 424

Query: 1106 LDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERN 1165
                 R  TD++EC +S        C++  G F C C  G+   +      +DIDEC+ +
Sbjct: 425  ---GPRCETDVNEC-LSGPCRNQATCLDRIGQFTCICMAGFTGTYCE----VDIDECQSS 476

Query: 1166 PLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNG-KCVNMIGTYQ 1224
            P +  GG C +    F C CP G   S  +   +D++EC+ +   CRNG KCV+    Y+
Sbjct: 477  PCV-NGGVCKDRVNGFSCTCPSGFSGSTCQ---LDVDECASTP--CRNGAKCVDQPDGYE 530

Query: 1225 CSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC-AD 1283
            C C  G++ T   +   D       +G    +C +   S+ C+C+ GY     G  C + 
Sbjct: 531  CRCAEGFEGTLCDRNVDDCSPDPCHHG----RCVDGIASFSCACAPGYT----GTRCESQ 582

Query: 1284 IDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECEN 1343
            +DEC + P    GG+C ++  +Y C C  G           +VN  D  SN C FG C +
Sbjct: 583  VDECRSQP-CRHGGKCLDLVDKYLCRCPSGTTG-----VNCEVNIDDCASNPCTFGVCRD 636

Query: 1344 TKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNG 1403
                + C CQ G++   G     +++EC   +  C    SC++    F+C C  G     
Sbjct: 637  GINRYDCVCQPGFT---GPLCNVEINEC--ASSPCGEGGSCVDGENGFRCLCPPG----S 687

Query: 1404 IKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENG 1463
            +  + L       H+   +  C + PG +RC C  G++G   + S   +  E+      G
Sbjct: 688  LPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGG 747

Query: 1464 QCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVF-GTCNNLPGMFH-CICDDGY 1521
             C +    + C C     P    R C+ +  C+  N C   G C + PG    C C  G+
Sbjct: 748  TCSSDGMGFHCTC----PPGVQGRQCELLSPCT-PNPCEHGGRCESAPGQLPVCSCPQGW 802

Query: 1522 ELDRTGGNC-TDIDECADPINC-VNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNC 1579
            +    G  C  D+DECA P  C  +G+C N  G + C C   +    TG  C D  + +C
Sbjct: 803  Q----GPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGY----TGPSC-DQDINDC 853

Query: 1580 ----YLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPC--ETCPPVNSTEYYTLC 1633
                 L  G   DG  S +     G +   C   + +   NPC   TC    ++   T  
Sbjct: 854  DPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCP 913

Query: 1634 PGGEGFRPNPITIILEDIDECQELPGLC-QGGNCINTFGSFQCECPQGYYLSEDTRICED 1692
            PG  GF         +D+ +C   P  C  GG C++   SF C C  GY          +
Sbjct: 914  PGYGGFHCE------QDLPDCS--PSSCFNGGTCVDGVNSFSCLCRPGY---TGAHCQHE 962

Query: 1693 IDECFAHP----GVCG---PG---TCYNTLGNYTC-----ICPPEYMQVNGGHNCMDMRK 1737
             D C + P    GVC    PG   TC  +     C      C  +  Q NGG        
Sbjct: 963  ADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQ-NGGRCVQTGAY 1021

Query: 1738 SFCYRSYNGTTCE-NELP-------FNVTKRMCC--------------CTYNVGKAWN-- 1773
              C   ++G  C+   LP         V     C              C    G+  +  
Sbjct: 1022 CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHC 1081

Query: 1774 ----KPC--EPCPTPGTADFKT---ICGNIPGFTFDIHTGKAVDIDECKEIPGICAN-GV 1823
                 PC  +PC   GT        +C  +PG+  D       D+DEC   P  C + G 
Sbjct: 1082 EQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGD---NCEDDVDECASQP--CQHGGS 1136

Query: 1824 CINQIGSFRCECPTGFSYNDLLLVCE-DIDECSNGDNL-----CQRNADCINSPGSYRCE 1877
            CI+ +  + C CP G     L ++CE + D+C  G  L     C  N  C++  G +RC 
Sbjct: 1137 CIDLVARYLCSCPPG----TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCT 1192

Query: 1878 CAAGFKLSPNGACVDRNECLEIPNVCSH--GLCVDLQGSYQCICHNGFKASQDQTMCMDV 1935
            C  G+  +      D NEC       +H      D  G ++C+CH GF   + QT+   +
Sbjct: 1193 CPPGY--TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTV---L 1247

Query: 1936 DECERHPCGN-GTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEI 1994
              CE  PC + G C+ + G       PG  LT    C        F+G  C   R     
Sbjct: 1248 SPCESQPCQHGGQCRPSPG-------PGGGLTFTCHC-----AQPFWGPRCE--RVARSC 1293

Query: 1995 GSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENC 2054
               +C      + TP G  C       A P   S  +C++  GS     PPG    S   
Sbjct: 1294 RELQCPVGVPCQQTPRGPRC-------ACPPGLSGPSCRSFPGS-----PPGASNAS--- 1338

Query: 2055 IDINECDEDPNICLF-GSCTNTPGG--FQCLCPPGFVLSDNGRRC 2096
                 C   P  CL  GSC   P    F+C C  G+     G RC
Sbjct: 1339 -----CAAAP--CLHGGSCRPAPLAPFFRCACAQGW----TGPRC 1372



 Score =  367 bits (941), Expect = e-100
 Identities = 378/1355 (27%), Positives = 534/1355 (39%), Gaps = 291/1355 (21%)

Query: 517  YRCECNMGYKQDANGDCIDVDECTSNPCTNGD--CVNTPGSYYCKCHAGFQRTPTKQACI 574
            + C C  G++     DC   D C S+PC +G    V   G + C C  G+Q    +    
Sbjct: 104  FSCRCPRGFR---GPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRS--- 157

Query: 575  DIDECIQNGVLCKNG-RCVNTDGSFQCICNAGF--------------------------- 606
            D+DEC + G  C++G  C+NT GSF+C C AG+                           
Sbjct: 158  DVDEC-RVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSG 216

Query: 607  ELTTD--------GKNC-VDHDECTTTNMCLN-GMCINEDGSFKCICKPGFVLAPNGRYC 656
            +LT D        G+NC V+ D+C   + CLN G C++   ++ C C P +     G++C
Sbjct: 217  DLTYDCACLPGFEGQNCEVNVDDC-PGHRCLNGGTCVDGVNTYNCQCPPEW----TGQFC 271

Query: 657  T-DVDECQ-TPGICMN-GHCINSEGSFRCDCPPG-----LAVGMDGRVCVDTHMRSTCYG 708
            T DVDECQ  P  C N G C N+ G   C C  G      +  +D          +TC+ 
Sbjct: 272  TEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHD 331

Query: 709  GIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQP---CPAKNSAEFHGLCSSGVGIT-- 763
             +    C  P    + K+   C   D     PC     C   N      +C+   G T  
Sbjct: 332  RVASFYCACP----MGKTGLLCHLDDACVSNPCHEDAICDT-NPVNGRAICTCPPGFTGG 386

Query: 764  VDGRDINECALDPDICAN-GICENLRGSYRCNCNSGYEPDASGRNC-IDIDECLVNRLLC 821
               +D++EC++  + C + G C N +GS+ C C  GY    +G  C  D++ECL     C
Sbjct: 387  ACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY----TGPRCETDVNECLSGP--C 440

Query: 822  DN-GLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVN-GACRNNLGSFNCECSP 879
             N   C +  G ++C C  G+   T T    DI+EC+S+PCVN G C++ +  F+C C  
Sbjct: 441  RNQATCLDRIGQFTCICMAGF---TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPS 497

Query: 880  GSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPC--ERCEL 937
            G   S            TC L++ +                CA+     G+ C  +    
Sbjct: 498  GFSGS------------TCQLDVDE----------------CASTPCRNGAKCVDQPDGY 529

Query: 938  DTACPRGLARIKGVTCE-DVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCL 996
            +  C  G    +G  C+ +V++C   P  C +GRCV+   SF C C  G     TG  C 
Sbjct: 530  ECRCAEG---FEGTLCDRNVDDCS--PDPCHHGRCVDGIASFSCACAPGY----TGTRC- 579

Query: 997  DIRMEQCYLKWDEDECIHPVPGKFRMD--ACCCAVGAAWGTECE----ECP--------- 1041
            + ++++C        C H       +D   C C  G   G  CE    +C          
Sbjct: 580  ESQVDEC----RSQPCRHGGKCLDLVDKYLCRCPSGTT-GVNCEVNIDDCASNPCTFGVC 634

Query: 1042 KPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCN 1101
            + G   Y+ +C  G          TG     +INEC + P     G C +    F+C C 
Sbjct: 635  RDGINRYDCVCQPG---------FTGPLCNVEINECASSP-CGEGGSCVDGENGFRCLCP 684

Query: 1102 SGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDE 1161
             G    +          C   P  C  GIC + PG F C C  G+          +  D 
Sbjct: 685  PG---SLPPLCLPPSHPCAHEP--CSHGICYDAPGGFRCVCEPGWSG--PRCSQSLARDA 737

Query: 1162 CERNPLLCR-GGTCVNTEGSFQCDCPLGHE------LSP-SREDC--------------- 1198
            CE  P  CR GGTC +    F C CP G +      LSP +   C               
Sbjct: 738  CESQP--CRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPV 795

Query: 1199 -------------VDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDE 1245
                          D++EC+       +G C N+ G++ C+C+ GY      Q   D D 
Sbjct: 796  CSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDP 855

Query: 1246 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCA-DIDECENNPDICDGGQCTNIPG 1304
               +NGG    C +  GS+ CSC  G+A    G  CA D+DEC +NP  C  G CT+   
Sbjct: 856  NPCLNGG---SCQDGVGSFSCSCLPGFA----GPRCARDVDECLSNP--CGPGTCTDHVA 906

Query: 1305 EYRCLC---YDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKG 1361
             + C C   Y GF    D+  C         S+    G C +   SF C C+ GY+   G
Sbjct: 907  SFTCTCPPGYGGFHCEQDLPDCSP-------SSCFNGGTCVDGVNSFSCLCRPGYT---G 956

Query: 1362 TTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSI 1421
                 + D C   +  C     C      F+C+C E + G   + + +D CS     C  
Sbjct: 957  AHCQHEADPCL--SRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTL-VDWCSR--QPCQN 1011

Query: 1422 NAQCVNTPGSYRCACSEGFTGD--GFTCSDVDECAENI-----NLCE-NGQCLNVPGAYR 1473
              +CV T G+Y C C  G++G           E A  I      LC+  GQC++   ++ 
Sbjct: 1012 GGRCVQT-GAY-CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHY 1069

Query: 1474 CECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNC-TD 1532
            C C  G T    S   Q++D C  Q     GTC    G + C C  GY     G NC  D
Sbjct: 1070 CVCPEGRT---GSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY----NGDNCEDD 1122

Query: 1533 IDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNC----YLKFGPRGD 1588
            +DECA       G C++   RY C+CPP       GV C  N   +C     L  GPR  
Sbjct: 1123 VDECASQPCQHGGSCIDLVARYLCSCPP----GTLGVLCEINE-DDCGPGPPLDSGPRCL 1177

Query: 1589 GSLSCNTEIG-------VGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFR- 1640
             + +C   +G        G +   C   + +     C        T      PGG GFR 
Sbjct: 1178 HNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAA----HTRDCLQDPGG-GFRC 1232

Query: 1641 --------PNPITIILEDIDECQELPGLCQ-GGNCINTFG-----SFQCECPQGYYLSED 1686
                    P   T+    +  C+  P  CQ GG C  + G     +F C C Q ++    
Sbjct: 1233 LCHAGFSGPRCQTV----LSPCESQP--CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRC 1286

Query: 1687 TRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPP 1721
             R+     E     GV     C  T     C CPP
Sbjct: 1287 ERVARSCRELQCPVGV----PCQQTPRGPRCACPP 1317



 Score =  362 bits (929), Expect = 3e-99
 Identities = 426/1620 (26%), Positives = 602/1620 (37%), Gaps = 377/1620 (23%)

Query: 125  SRPNMCTCSSGQISSTCGSKSIQQC-SVRCMNGGTCADD--------HCQCQKGYIGTYC 175
            SR   C C  G +   C  +    C S  C   G C            C+C +G+ G  C
Sbjct: 60   SREAACLCPPGWVGERCQLED--PCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDC 117

Query: 176  G--QPVCENGCQNGGRC-IGPNR---CACVYGFTGPQCERDY---RTGPCFTQVNNQMCQ 226
                P   + C +G RC +GP+    C+C  G+ G  C  D    R G        + C+
Sbjct: 118  SLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG--------EPCR 169

Query: 227  GQLTGIVCTKTLCCATIGRAWGHPCE--MCPAQPQPCRRG--------------FIPNIR 270
               T +    +  C       G  CE    P  P PCR G               +P   
Sbjct: 170  HGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFE 229

Query: 271  TGACQ-DVDECQAIPG--ICQGGNCINTVGSFECRCPAGHKQSETTQKC-EDIDECSIIP 326
               C+ +VD+C   PG     GG C++ V ++ C+CP       T Q C ED+DEC + P
Sbjct: 230  GQNCEVNVDDC---PGHRCLNGGTCVDGVNTYNCQCPP----EWTGQFCTEDVDECQLQP 282

Query: 327  GICETG-ECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTK 385
              C  G  C NT+G + CVC  G+   +      D  T +CF G            R+  
Sbjct: 283  NACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGAT-------CHDRVAS 335

Query: 386  MQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGN----- 440
              C C  G+   +  + +AC      E   +C D  P+ G        PG TGG      
Sbjct: 336  FYCACPMGKTGLLCHLDDACVSNPCHE-DAIC-DTNPVNG-RAICTCPPGFTGGACDQDV 392

Query: 441  -----GFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQ-- 493
                 G  P  +  G      G      G G++       V     GP     T L++  
Sbjct: 393  DECSIGANPCEH-LGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIG 451

Query: 494  ---------------TIDICKHHANLCLNGR-CIPTVSSYRCECNMGYKQDANGDC-IDV 536
                            +DI +  ++ C+NG  C   V+ + C C  G+   +   C +DV
Sbjct: 452  QFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGF---SGSTCQLDV 508

Query: 537  DECTSNPCTNG-DCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTD 595
            DEC S PC NG  CV+ P  Y C+C  GF+ T   +   ++D+C  +   C +GRCV+  
Sbjct: 509  DECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDR---NVDDCSPDP--CHHGRCVDGI 563

Query: 596  GSFQCICNAGFELT----------------------------------TDGKNC-VDHDE 620
             SF C C  G+  T                                  T G NC V+ D+
Sbjct: 564  ASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDD 623

Query: 621  CTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYC-TDVDECQTPGICMNGHCINSEGS 679
            C  +N C  G+C +    + C+C+PGF     G  C  +++EC +      G C++ E  
Sbjct: 624  C-ASNPCTFGVCRDGINRYDCVCQPGF----TGPLCNVEINECASSPCGEGGSCVDGENG 678

Query: 680  FRCDCPPGLAVGM-------------DGRVCVDT--HMRSTCYGGIKKGVCVRPFPGAVT 724
            FRC CPPG    +                +C D     R  C  G     C +       
Sbjct: 679  FRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDAC 738

Query: 725  KSECC-----CANPDYGF---------GEPCQ---PCPAKNSAEFHGLCSSGVG-ITVDG 766
            +S+ C     C++   GF         G  C+   PC   N  E  G C S  G + V  
Sbjct: 739  ESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPC-TPNPCEHGGRCESAPGQLPVCS 797

Query: 767  -----------RDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNC-IDIDEC 814
                       +D++ECA       +GIC NL GS+ C C+ GY    +G +C  DI++C
Sbjct: 798  CPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGY----TGPSCDQDINDC 853

Query: 815  LVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFN 874
              N  L + G C++  GS+SC+C PG+          D++EC SNPC  G C +++ SF 
Sbjct: 854  DPNPCL-NGGSCQDGVGSFSCSCLPGF---AGPRCARDVDECLSNPCGPGTCTDHVASFT 909

Query: 875  CECSPGSKLSSTGLICIDSLK----------GTC--WLNIQDSRCEVNINGATLKSEC-- 920
            C C PG      G  C   L           GTC   +N     C     GA  + E   
Sbjct: 910  CTCPPG----YGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADP 965

Query: 921  CATLGAAWGSPCERCELDTACPRGLARIKGVTCED-VNECEVFPGVCPN-GRCVNSKGSF 978
            C +     G  C        C   L    G  C+  V+ C   P  C N GRCV +    
Sbjct: 966  CLSRPCLHGGVCSAAHPGFRC-TCLESFTGPQCQTLVDWCSRQP--CQNGGRCVQT--GA 1020

Query: 979  HCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECE 1038
            +C CP G     +GR+C DIR   C       E    +    R++  C A G        
Sbjct: 1021 YCLCPPG----WSGRLC-DIRSLPC------REAAAQI--GVRLEQLCQAGG-------- 1059

Query: 1039 ECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTY-GKCRNTIGSFK 1097
            +C    +  Y  +CP G          TG    ++++ C A P  C + G CR  +G + 
Sbjct: 1060 QCVDEDSSHY-CVCPEGR---------TGSHCEQEVDPCLAQP--CQHGGTCRGYMGGYM 1107

Query: 1098 CRCNSGFALDMEERNC-TDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNC 1156
            C C  G+  D    NC  D+DEC   P   G G C++    + C C      G + +   
Sbjct: 1108 CECLPGYNGD----NCEDDVDECASQPCQHG-GSCIDLVARYLCSC----PPGTLGVLCE 1158

Query: 1157 MDIDECERNPLLCRG------GTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNL 1210
            ++ D+C   P L  G      GTCV+  G F+C CP G+              C    N 
Sbjct: 1159 INEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGL----------RCEADINE 1208

Query: 1211 CRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSE 1270
            CR+G C +   T  C  +PG                               G + C C  
Sbjct: 1209 CRSGAC-HAAHTRDCLQDPG-------------------------------GGFRCLCHA 1236

Query: 1271 GYALMPDGRSCADI-DECENNPDICD-GGQCTNIPG-----EYRCLCYDGFMASMDMKTC 1323
            G++    G  C  +   CE+ P  C  GGQC   PG      + C C   F      +  
Sbjct: 1237 GFS----GPRCQTVLSPCESQP--CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVA 1290

Query: 1324 IDVNECDLNSNICMFG-ECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHA 1382
                E       C  G  C+ T     C C  G S       C        GA N    A
Sbjct: 1291 RSCRELQ-----CPVGVPCQQTPRGPRCACPPGLS----GPSCRSFPGSPPGASNASCAA 1341

Query: 1383 S-CLN--------IPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYR 1433
            + CL+        +   F+C+C +GW G   +        +   +C   A C    G  R
Sbjct: 1342 APCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCP-RAACQAKRGDQR 1400

Query: 1434 C---ACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQ 1490
            C     S G   DG  CS      +    CE  QC  +    RC+      PA  S +  
Sbjct: 1401 CDRECNSPGCGWDGGDCS--LSVGDPWRQCEALQCWRLFNNSRCD------PACSSPA-- 1450

Query: 1491 DIDECSFQNI-CVFG----TCNNLPGMFHCICDDGYELDRTGGNCTDIDECA-DPINCVN 1544
                C + N  C  G    TCN    ++   C D +   R    C + +EC  D ++C +
Sbjct: 1451 ----CLYDNFDCHAGGRERTCN---PVYEKYCADHFADGRCDQGC-NTEECGWDGLDCAS 1502



 Score =  318 bits (816), Expect = 4e-86
 Identities = 392/1469 (26%), Positives = 545/1469 (37%), Gaps = 293/1469 (19%)

Query: 354  DGSRCID----QRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRG 409
            +G RC      +   +C  G V  RC  E P         C  G C G G + ++  V G
Sbjct: 51   NGGRCTQLPSREAACLCPPGWVGERCQLEDP---------CHSGPCAGRG-VCQSSVVAG 100

Query: 410  SEEYRRLCMDGL--PMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGF 467
            +  +   C  G   P   +P    S P   G             GP G      P     
Sbjct: 101  TARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARC--------SVGPDGRFLCSCP----- 147

Query: 468  SPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQ 527
             PG  G                     +D C+        G C+ T  S+RC+C  GY  
Sbjct: 148  -PGYQGRSC---------------RSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTG 191

Query: 528  DANGDCIDVDECTSNPCTNGDCVNTPG--SYYCKCHAGFQRTPTKQAC-IDIDECIQNGV 584
                +      C  +PC NG      G  +Y C C  GF+     Q C +++D+C   G 
Sbjct: 192  PLCEN--PAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFE----GQNCEVNVDDC--PGH 243

Query: 585  LCKN-GRCVNTDGSFQCICNAGFELTTDGKNCV-DHDEC-TTTNMCLN-GMCINEDGSFK 640
             C N G CV+   ++ C C   +     G+ C  D DEC    N C N G C N  G   
Sbjct: 244  RCLNGGTCVDGVNTYNCQCPPEW----TGQFCTEDVDECQLQPNACHNGGTCFNTLGGHS 299

Query: 641  CICKPGFVLAPNGRYCT-DVDECQTPGICMNG-HCINSEGSFRCDCP---PGLAVGMD-- 693
            C+C  G+     G  C+ ++D+C T  +C +G  C +   SF C CP    GL   +D  
Sbjct: 300  CVCVNGW----TGESCSQNIDDCAT-AVCFHGATCHDRVASFYCACPMGKTGLLCHLDDA 354

Query: 694  --------GRVC----VDTHMRSTCYGGIKKGVCVRPFPGAVTKSECC-----CANPDYG 736
                      +C    V+     TC  G   G C +        +  C     C N    
Sbjct: 355  CVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGS 414

Query: 737  F---------GEPCQ----PC---PAKNSA-------EFHGLCSSGVGITVDGRDINECA 773
            F         G  C+     C   P +N A       +F  +C +G   T    DI+EC 
Sbjct: 415  FLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQ 474

Query: 774  LDPDICAN-GICENLRGSYRCNCNSGYEPDASGRNC-IDIDECLVNRLLCDNGL-CRNTP 830
              P  C N G+C++    + C C SG+    SG  C +D+DEC      C NG  C + P
Sbjct: 475  SSP--CVNGGVCKDRVNGFSCTCPSGF----SGSTCQLDVDECASTP--CRNGAKCVDQP 526

Query: 831  GSYSCTCPPGYVFRTETETCE-DINECESNPCVNGACRNNLGSFNCECSPG--------- 880
              Y C C  G+    E   C+ ++++C  +PC +G C + + SF+C C+PG         
Sbjct: 527  DGYECRCAEGF----EGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQ 582

Query: 881  -----SKLSSTGLICIDSLKG---TCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPC 932
                 S+    G  C+D +      C        CEVNI+        CA+    +G   
Sbjct: 583  VDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDD-------CASNPCTFGVCR 635

Query: 933  ERC-ELDTACPRGLARIKGVTCE-DVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDG 990
            +     D  C  G     G  C  ++NEC   P     G CV+ +  F C CP G     
Sbjct: 636  DGINRYDCVCQPGFT---GPLCNVEINECASSP-CGEGGSCVDGENGFRCLCPPG----S 687

Query: 991  TGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEE------CPKPG 1044
               +CL       +       C +  PG FR   C C  G + G  C +      C    
Sbjct: 688  LPPLCLPPSHPCAHEPCSHGIC-YDAPGGFR---CVCEPGWS-GPRCSQSLARDACESQP 742

Query: 1045 TKEYETLCPRGAGF-ANRGDVLTGRPFYKDINECKAFPGMCTY-GKCRNTIGSFK-CRCN 1101
             +   T    G GF       + GR   + ++ C   P  C + G+C +  G    C C 
Sbjct: 743  CRAGGTCSSDGMGFHCTCPPGVQGRQ-CELLSPCT--PNPCEHGGRCESAPGQLPVCSCP 799

Query: 1102 SGFALDMEERNCTDIDECRISPDLCG-SGICVNTPGSFECECFEGYESGFMMMKNC-MDI 1159
             G+      R   D+DEC   P  CG  GIC N  GSF C C  GY        +C  DI
Sbjct: 800  QGW---QGPRCQQDVDEC-AGPAPCGPHGICTNLAGSFSCTCHGGYTG-----PSCDQDI 850

Query: 1160 DECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCV-DINECSLSDNLCRNGKCVN 1218
            ++C+ NP L  GG+C +  GSF C C  G     +   C  D++EC    N C  G C +
Sbjct: 851  NDCDPNPCL-NGGSCQDGVGSFSCSCLPGF----AGPRCARDVDEC--LSNPCGPGTCTD 903

Query: 1219 MIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDG 1278
             + ++ C+C PGY      Q   D       NGG    C +   S+ C C  GY     G
Sbjct: 904  HVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGG---TCVDGVNSFSCLCRPGYT----G 956

Query: 1279 RSCA-DIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICM 1337
              C  + D C + P +  GG C+     +RC C + F             +C    + C 
Sbjct: 957  AHCQHEADPCLSRPCL-HGGVCSAAHPGFRCTCLESFTGP----------QCQTLVDWCS 1005

Query: 1338 FGECEN----TKGSFICHCQLGYSVKK---GTTGCTDVDECEIGA---HNCDMHASCLNI 1387
               C+N     +    C C  G+S +     +  C +    +IG      C     C++ 
Sbjct: 1006 RQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREA-AAQIGVRLEQLCQAGGQCVDE 1064

Query: 1388 PGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC 1447
              S  C C EG  G+  +  ++D C      C     C    G Y C C  G+ GD    
Sbjct: 1065 DSSHYCVCPEGRTGSHCE-QEVDPCL--AQPCQHGGTCRGYMGGYMCECLPGYNGDNCE- 1120

Query: 1448 SDVDECAENINLCEN-GQCLNVPGAYRCECEMGFTPASDSRSCQ-DIDEC-------SFQ 1498
             DVDECA     C++ G C+++   Y C C     P +    C+ + D+C       S  
Sbjct: 1121 DDVDECAS--QPCQHGGSCIDLVARYLCSC----PPGTLGVLCEINEDDCGPGPPLDSGP 1174

Query: 1499 NICVFGTCNNLPGMFHCICDDGYELDRTGGNC-TDIDECADPI--NCVNGLCVNTP-GRY 1554
                 GTC +L G F C C  GY    TG  C  DI+EC            C+  P G +
Sbjct: 1175 RCLHNGTCVDLVGGFRCTCPPGY----TGLRCEADINECRSGACHAAHTRDCLQDPGGGF 1230

Query: 1555 ECNCPPDFQ-------LNP-TGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSR--- 1603
             C C   F        L+P     C     G C    GP G  + +C+        R   
Sbjct: 1231 RCLCHAGFSGPRCQTVLSPCESQPC--QHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCER 1288

Query: 1604 -SSCCCSLGKAWGNPCE--------TCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDEC 1654
             +  C  L    G PC+         CPP  S       PG      N           C
Sbjct: 1289 VARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNA---------SC 1339

Query: 1655 QELPGLCQGGNC--INTFGSFQCECPQGY 1681
               P L  GG+C        F+C C QG+
Sbjct: 1340 AAAPCL-HGGSCRPAPLAPFFRCACAQGW 1367



 Score =  256 bits (654), Expect = 2e-67
 Identities = 322/1192 (27%), Positives = 429/1192 (35%), Gaps = 268/1192 (22%)

Query: 89   CGSRFHS-YC-CPGWKT---LPGGNQCIVPICRNS--CGDGFCSRPNMCTCSSGQISSTC 141
            C  R  S YC CP  KT       + C+   C     C     +   +CTC  G     C
Sbjct: 329  CHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGAC 388

Query: 142  GSKSIQQCSVR---CMNGGTCADDH----CQCQKGYIGTYCGQPV--CENG-CQNGGRC- 190
              + + +CS+    C + G C +      CQC +GY G  C   V  C +G C+N   C 
Sbjct: 389  -DQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCL 447

Query: 191  --IGPNRCACVYGFTGPQCERDY---RTGPCFTQVNNQMCQGQLTGIVCT------KTLC 239
              IG   C C+ GFTG  CE D    ++ PC   VN  +C+ ++ G  CT       + C
Sbjct: 448  DRIGQFTCICMAGFTGTYCEVDIDECQSSPC---VNGGVCKDRVNGFSCTCPSGFSGSTC 504

Query: 240  CATIGRAWGHPCE---MCPAQPQ----PCRRGFIPNIRTGACQDVDECQAIPGICQGGNC 292
               +      PC     C  QP      C  GF   +     ++VD+C   P  C  G C
Sbjct: 505  QLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTL---CDRNVDDCS--PDPCHHGRC 559

Query: 293  INTVGSFECRCPAGHKQSETTQKCE-DIDECSIIPGICETGECSNTVGSYFCVCPRGYVT 351
            ++ + SF C C  G+    T  +CE  +DEC   P     G+C + V  Y C CP G   
Sbjct: 560  VDGIASFSCACAPGY----TGTRCESQVDECRSQP-CRHGGKCLDLVDKYLCRCPSG--- 611

Query: 352  STDGSRC---IDQ------RTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIP 402
             T G  C   ID         G+C  G+    C  + PG  T   C  E   C       
Sbjct: 612  -TTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQ-PG-FTGPLCNVEINECASSPCGE 668

Query: 403  EACPVRGSEEYRRLCMDG-LPMGGIP------------GSAGSRPGG------TGGNG-- 441
                V G   +R LC  G LP   +P            G     PGG       G +G  
Sbjct: 669  GGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPR 728

Query: 442  -----------FAPSGNGNGYGPGGTGF--IPIPGGNG-----FSPGV------GGAGVG 477
                         P   G      G GF     PG  G      SP        GG    
Sbjct: 729  CSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCES 788

Query: 478  AGGQGPIIT-----GLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGD 532
            A GQ P+ +           Q +D C   A    +G C     S+ C C+ GY   +   
Sbjct: 789  APGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQ 848

Query: 533  CIDVDECTSNPCTN-GDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRC 591
              D+++C  NPC N G C +  GS+ C C  GF      +   D+DEC+ N   C  G C
Sbjct: 849  --DINDCDPNPCLNGGSCQDGVGSFSCSCLPGF---AGPRCARDVDECLSNP--CGPGTC 901

Query: 592  VNTDGSFQCICNAGFELTTDGKNC-VDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLA 650
             +   SF C C  G+     G +C  D  +C+ ++    G C++   SF C+C+PG+   
Sbjct: 902  TDHVASFTCTCPPGY----GGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGY--- 954

Query: 651  PNGRYCT-DVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGG 709
              G +C  + D C +      G C  +   FRC C      G   +  VD   R  C  G
Sbjct: 955  -TGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESF-TGPQCQTLVDWCSRQPCQNG 1012

Query: 710  IKKGVCVRPFPGAVTKSECCCANPDYGFGE-------PCQPCPAKNSAEFHGLCSSGVGI 762
               G CV+      T + C C  P    G        PC+   A+       LC +G G 
Sbjct: 1013 ---GRCVQ------TGAYCLC--PPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAG-GQ 1060

Query: 763  TVD-----------GRDINECALDPDICA------NGICENLRGSYRCNCNSGYEPDASG 805
             VD           GR  + C  + D C        G C    G Y C C  GY    +G
Sbjct: 1061 CVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY----NG 1116

Query: 806  RNC-IDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNP---- 860
             NC  D+DEC  ++     G C +    Y C+CPPG    T    CE INE +  P    
Sbjct: 1117 DNCEDDVDEC-ASQPCQHGGSCIDLVARYLCSCPPG----TLGVLCE-INEDDCGPGPPL 1170

Query: 861  -----CV-NGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGA 914
                 C+ NG C + +G F C C PG     TGL C   +          + C      A
Sbjct: 1171 DSGPRCLHNGTCVDLVGGFRCTCPPG----YTGLRCEADI----------NECRSGACHA 1216

Query: 915  TLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPG---------- 964
                +C    G  +   C        C   L+  +   C+   +C   PG          
Sbjct: 1217 AHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCH 1276

Query: 965  --------------------VCPNG-RCVNSKGSFHCECPEGLTLDGTGRVCLDIRME-- 1001
                                 CP G  C  +     C CP GL    +G  C        
Sbjct: 1277 CAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGL----SGPSCRSFPGSPP 1332

Query: 1002 -QCYLKWDEDECIH-------PVPGKFRMDACCCAVGAAW-GTECEECPKPGTKEYETLC 1052
                       C+H       P+   FR   C CA G  W G  CE          E  C
Sbjct: 1333 GASNASCAAAPCLHGGSCRPAPLAPFFR---CACAQG--WTGPRCEAPAAAPEVSEEPRC 1387

Query: 1053 PRGAGFANRGDVLTGRPFYKDINECKAFPGMCTY--GKCRNTIGSFKCRCNS 1102
            PR A  A RGD    R       EC + PG C +  G C  ++G    +C +
Sbjct: 1388 PRAACQAKRGDQRCDR-------ECNS-PG-CGWDGGDCSLSVGDPWRQCEA 1430



 Score =  166 bits (420), Expect = 3e-40
 Identities = 140/491 (28%), Positives = 206/491 (41%), Gaps = 103/491 (20%)

Query: 2321 CICPPGMARRPDGEGCVDENECRTKP----GICENGRCVNIIGSYRCECNEGFQSSSSGT 2376
            C+CPPG      GE C  E+ C + P    G+C++   V     + C C  GF+    G 
Sbjct: 65   CLCPPGWV----GERCQLEDPCHSGPCAGRGVCQSS-VVAGTARFSCRCPRGFR----GP 115

Query: 2377 ECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKI 2436
            +C            L   C            S  C  G R        C +    ++   
Sbjct: 116  DCS-----------LPDPCL-----------SSPCAHGAR--------CSVGPDGRFLCS 145

Query: 2437 CPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECS 2496
            CP G    +   D+DEC+V       G C+NT GSFRC C  GYT  +     +    C+
Sbjct: 146  CPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAV---PCA 202

Query: 2497 QSPKPCNYICKNT-EGSYQCSCPRGYVLQEDGKTCK-DLDECQTKQHNCQFLCVNTLGGF 2554
             SP      C+ + + +Y C+C  G+    +G+ C+ ++D+C   +      CV+ +  +
Sbjct: 203  PSPCRNGGTCRQSGDLTYDCACLPGF----EGQNCEVNVDDCPGHRCLNGGTCVDGVNTY 258

Query: 2555 TCKCPPGFT-QHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNC- 2612
             C+CPP +T Q  T  +D  EC  QP+ C   G C NT G  SC C  G+    TG +C 
Sbjct: 259  NCQCPPEWTGQFCTEDVD--ECQLQPNACHNGGTCFNTLGGHSCVCVNGW----TGESCS 312

Query: 2613 EDVDECDGNHRCQHG--CQNILGGYRCGCPQ---GYIQHYQWNQCVDENECSNPNACGSA 2667
            +++D+C     C HG  C + +  + C CP    G + H   + CV  N C     C + 
Sbjct: 313  QNIDDC-ATAVCFHGATCHDRVASFYCACPMGKTGLLCHLD-DACV-SNPCHEDAICDTN 369

Query: 2668 SCYNTLGSYKCACPSGFSFDQFSSAC-HDVNECSSSKNPCNY--GCSNTEGGYLCGCPPG 2724
                  G   C CP GF+      AC  DV+ECS   NPC +   C NT+G +LC C  G
Sbjct: 370  P---VNGRAICTCPPGFT----GGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRG 422

Query: 2725 YY------------------------RVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPE 2760
            Y                         R+GQ  C+   GF  G Y  +D +  + +     
Sbjct: 423  YTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFT-GTYCEVDIDECQSSPCVNG 481

Query: 2761 ACYECKINGYS 2771
               + ++NG+S
Sbjct: 482  GVCKDRVNGFS 492



 Score = 38.5 bits (88), Expect = 0.098
 Identities = 41/158 (25%), Positives = 54/158 (34%), Gaps = 33/158 (20%)

Query: 80   QDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPN---------MC 130
            +D L+ P   G  F   C  G+   P     + P     C  G   RP+          C
Sbjct: 1220 RDCLQDP---GGGFRCLCHAGFSG-PRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTC 1275

Query: 131  TCSSGQISSTCGSKSIQQCSVRCMNGGTCADD----HCQCQKGYIGTYC-----GQPVCE 181
             C+       C   +     ++C  G  C        C C  G  G  C       P   
Sbjct: 1276 HCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGAS 1335

Query: 182  NG------CQNGGRC----IGPN-RCACVYGFTGPQCE 208
            N       C +GG C    + P  RCAC  G+TGP+CE
Sbjct: 1336 NASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCE 1373


>gi|18497288 latent transforming growth factor beta binding protein 3
            isoform 2 [Homo sapiens]
          Length = 1256

 Score =  441 bits (1135), Expect = e-123
 Identities = 308/998 (30%), Positives = 426/998 (42%), Gaps = 158/998 (15%)

Query: 1014 HPVPGKFRMDACCCAVGAAWG-TECEECP--------KPGTKEYETL--CPRGAGFANRG 1062
            +P+PG  + + CC ++G AWG ++C +CP        KPG    E    CP+G    N  
Sbjct: 292  NPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNST 351

Query: 1063 DVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRIS 1122
                     +DINEC A PG+C +G C N  GS++C C  G +L      C  I +    
Sbjct: 352  HC-------QDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC--IADKPEE 401

Query: 1123 PDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDE-----CERNPLLCRGGTCVNT 1177
              LC   +      S E +C     +       C  + +     C+R P     GT    
Sbjct: 402  KSLCFRLV------SPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPT---DGTAAFK 452

Query: 1178 EGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDR 1237
            E    C    G+ +  S +      E   S  L  +G           S  P  + T + 
Sbjct: 453  E---ICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEE 509

Query: 1238 QGCTD---IDECMIMNGGCDTQCTNSEGSYECSCSEGYAL--------MPDGRSCADI-- 1284
            +G T    + E   +     T  T     Y    S             +P  RS  +I  
Sbjct: 510  RGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAP 569

Query: 1285 ------DECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMF 1338
                  DEC  N +IC  G+C   P +Y C C  G+ +    + C+DVNEC+        
Sbjct: 570  TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR 629

Query: 1339 GECENTKGSFICHCQLGYSVKKGTTG--CTDVDECEIGAHNCDMHASCLNIPGSFKCSCR 1396
            G C NT GS+ CHC  GY +  G  G  C D++EC    H C     C+N PG +KC+C 
Sbjct: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCY 688

Query: 1397 EGWIGNGIK---CIDLDECSNGTHQCSINAQCVNTPGSYRC-ACSEGFTGDGF-TCSDVD 1451
             G+     +   C D+DEC + +  C  + +C N PGS++C AC  G+   G   C DV+
Sbjct: 689  PGYRLKASRPPVCEDIDECRDPS-SCP-DGKCENKPGSFKCIACQPGYRSQGGGACRDVN 746

Query: 1452 ECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPG 1511
            ECAE  + C  G C N+PG++RC C  G+ PA D RSC D+DEC   ++C  G C+N PG
Sbjct: 747  ECAEG-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPG 805

Query: 1512 MFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLN------ 1565
             F C C  GY L R   +C DIDEC  P  C+ G C+NT G Y C CP   +L       
Sbjct: 806  SFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ 865

Query: 1566 -------------PTGV-----------------------GCVD----NRVGNCYLKFGP 1585
                         P G                        GC +    +    CYL F  
Sbjct: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNF-- 923

Query: 1586 RGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCET--CPPVNSTEYYTLCPGGEGFRPNP 1643
              D ++ C++ +   V++  CCCSLG  WG+ CE   CP  +S E+++LCP G+G+  + 
Sbjct: 924  --DDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDN 981

Query: 1644 ITIIL-----EDIDECQELPG-LCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECF 1697
              +        DIDEC      +C+ G C+NT   ++C C QG+Y   +   C D+DEC 
Sbjct: 982  NIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECL 1041

Query: 1698 AHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDM--------RKSFCY--RSYNGT 1747
                 C  G C NT G Y C C P          C+          R+  C+  R  +G 
Sbjct: 1042 DESN-CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGM 1100

Query: 1748 TCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDI------ 1801
                     +T   CCC    G+ W   C PCP  G         +     +D       
Sbjct: 1101 CAGPLAGPALTFDDCCCRQ--GRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLG 1158

Query: 1802 -----HTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECS- 1855
                       D DEC+     C +G C+ + G   CECP GF  +     C DIDEC  
Sbjct: 1159 KPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE 1213

Query: 1856 -NGDNLCQRNADCINSPGSYRCECAAGFKLS-PNGACV 1891
             N   L  ++  C+N+ GS+RC C AGF  S P+GACV
Sbjct: 1214 LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251



 Score =  388 bits (996), Expect = e-107
 Identities = 233/709 (32%), Positives = 325/709 (45%), Gaps = 93/709 (13%)

Query: 1105 ALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECER 1164
            A+++     T+ DECR++ ++CG G CV  P  + C C  GY S     + C+D++ECE 
Sbjct: 564  AVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRS-HPQHRYCVDVNECEA 622

Query: 1165 NPLLCRGGTCVNTEGSFQCDCPLGHEL--SPSREDCVDINECSLSDNLCRNGK-CVNMIG 1221
             P     G C+NT GS+ C C  G+ L        CVD+NEC+   +LC +G  C+N  G
Sbjct: 623  EPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPG 681

Query: 1222 TYQCSCNPGYQATPDRQG-CTDIDECMIMNGGCDTQCTNSEGSYEC-SCSEGYALMPDGR 1279
             Y+C+C PGY+    R   C DIDEC   +   D +C N  GS++C +C  GY     G 
Sbjct: 682  HYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGG- 740

Query: 1280 SCADIDEC-ENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMF 1338
            +C D++EC E +P  C  G C N+PG +RC C  G+  + D ++C+DV+EC+   ++C  
Sbjct: 741  ACRDVNECAEGSP--CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAG-DVCDN 797

Query: 1339 GECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREG 1398
            G C NT GSF C C  GY + +  + C D+DEC+  A    +   C+N  GS++C C +G
Sbjct: 798  GICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPA--ACIGGDCINTNGSYRCLCPQG 855

Query: 1399 W-IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTG--DGFTCSDVD---- 1451
              +  G KC D+DECS     C  +  C N  GSY C C EGFT   D   C +V+    
Sbjct: 856  HRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHH 915

Query: 1452 --ECAENIN---LCENGQCLNVPGAYRCECEMG--------------FTPASDSRSC--- 1489
              EC  N +    C++    NV     C C +G              ++ A     C   
Sbjct: 916  KKECYLNFDDTVFCDSVLATNVT-QQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDG 974

Query: 1490 -----------------QDIDECSF--QNICVFGTCNNLPGMFHCICDDGYELDRTGGNC 1530
                             +DIDEC      IC  G C N    + C C  G+  D     C
Sbjct: 975  KGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLEC 1034

Query: 1531 TDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVD--------NRVGNCYLK 1582
             D+DEC D  NC NG+C NT G Y C C P  + +P    C+          R   C+  
Sbjct: 1035 VDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCW-- 1092

Query: 1583 FGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPP-----------VNSTEYYT 1631
               RG+  +      G  ++   CCC  G+ WG  C  CPP             S  ++ 
Sbjct: 1093 -SQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWD 1151

Query: 1632 LCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICE 1691
              P   G  P       ED DEC+     C  G C+   G   CECP G+ L      C 
Sbjct: 1152 TSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCV 1206

Query: 1692 DIDEC--FAHPG-VCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRK 1737
            DIDEC      G +C    C NT G++ C+C   + +      C+  R+
Sbjct: 1207 DIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRR 1255



 Score =  345 bits (884), Expect = 5e-94
 Identities = 237/737 (32%), Positives = 324/737 (43%), Gaps = 127/737 (17%)

Query: 1357 SVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIK--CIDLDECSN 1414
            +V+   T  T+ DEC +  + C  H  C+  P  + C C  G+  +     C+D++EC  
Sbjct: 564  AVEIAPTQVTETDECRLNQNICG-HGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECE- 621

Query: 1415 GTHQCSINAQ-CVNTPGSYRCACSEGFT----GDGFTCSDVDECAENINLCENGQCLNVP 1469
                C      C+NT GSY C C+ G+       G +C D++ECA+     + G C+N P
Sbjct: 622  -AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFP 680

Query: 1470 GAYRCECEMGFT-PASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCI-CDDGYELDRTG 1527
            G Y+C C  G+   AS    C+DIDEC   + C  G C N PG F CI C  GY   + G
Sbjct: 681  GHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGG 739

Query: 1528 GNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRG 1587
            G C D++ECA+   C  G C N PG + C C   +   P G  C+D  V  C  + G   
Sbjct: 740  GACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD--VDEC--EAGDVC 795

Query: 1588 DGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITII 1647
            D  +  NT          C C  G         C                          
Sbjct: 796  DNGICSNTP-----GSFQCQCLSGYHLSRDRSHC-------------------------- 824

Query: 1648 LEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGP-G 1706
             EDIDEC + P  C GG+CINT GS++C CPQG+ L    R C+DIDEC   P +C P G
Sbjct: 825  -EDIDEC-DFPAACIGGDCINTNGSYRCLCPQGHRLVGG-RKCQDIDECSQDPSLCLPHG 881

Query: 1707 TCYNTLGNYTCICPPEYMQVNGGHNCMDMR----KSFCYRSYNGTT-CENELPFNVTKRM 1761
             C N  G+Y C+C   +      H C ++     K  CY +++ T  C++ L  NVT++ 
Sbjct: 882  ACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQE 941

Query: 1762 CCCTYNVGKAWNKPCE--PCPTPGTADFKTICGNIPGFTFD---IHTGKAV--DIDECKE 1814
            CCC+  +G  W   CE  PCP   +A+F ++C +  G+T D   ++ G     DIDEC  
Sbjct: 942  CCCS--LGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECML 999

Query: 1815 IPG-ICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGS 1873
                IC  G C+N    + C C  GF Y+  LL C D+DEC +  N   RN  C N+ G 
Sbjct: 1000 FGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNC--RNGVCENTRGG 1057

Query: 1874 YRCECAAGFKLSP-NGACVDRNECLEIP---NVC-----SHGLCV-DLQGSY----QCIC 1919
            YRC C    + SP    C+   E    P   +VC       G+C   L G       C C
Sbjct: 1058 YRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCC 1117

Query: 1920 HNG------------------FKASQDQTMCM--------------------DVDECERH 1941
              G                     SQ ++                       D DEC   
Sbjct: 1118 RQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-- 1175

Query: 1942 PCGNGTCKNTVGSYNCLCYPGFELTHNN-DCLDIDECSSF--FGQVCRNGRCFNEIGSFK 1998
             C +G C    G   C C  GF+L  +   C+DIDEC      G +C++ RC N  GSF+
Sbjct: 1176 -CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFR 1234

Query: 1999 CLCNEGYELTPDGKNCI 2015
            C+C  G+  +     C+
Sbjct: 1235 CVCKAGFARSRPHGACV 1251



 Score =  344 bits (882), Expect = 8e-94
 Identities = 228/727 (31%), Positives = 319/727 (43%), Gaps = 99/727 (13%)

Query: 2016 DTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPNICLFGSCT 2073
            +T+EC      C  G C      + C C PGY    ++  C+D+NEC+ +P     G C 
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633

Query: 2074 NTPGGFQCLCPPGFVL--SDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKM 2131
            NT G + C C  G+ L     GR C D  +           C+ P           C   
Sbjct: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNE-----------CAKPHLCGDGGF---CINF 679

Query: 2132 PGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTD 2191
            PG                 ++  C  G+    S     ED++EC + P  C +G+C N  
Sbjct: 680  PGH----------------YKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKP 722

Query: 2192 GSFRC-ECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPM-M 2249
            GSF+C  C  GY     G  C D +EC+ G+PC  G C N+ GSF C C +G+ P P   
Sbjct: 723  GSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGR 781

Query: 2250 NCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRG 2309
            +C D++EC    +     C NT GS++C C  GY L  D+  C+D+DEC          G
Sbjct: 782  SCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD---FPAACIG 838

Query: 2310 MMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGIC-ENGRCVNIIGSYRCECNEG 2368
              C N  G++ C+CP G  R   G  C D +EC   P +C  +G C N+ GSY C C+EG
Sbjct: 839  GDCINTNGSYRCLCPQGH-RLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEG 897

Query: 2369 FQSSSSGTECLDNRQGL----CFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCEL 2424
            F  +     C +  Q      C+     T+   +  + N VT+ ECCC  G GWG  CE+
Sbjct: 898  FTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATN-VTQQECCCSLGAGWGDHCEI 956

Query: 2425 --CPLPGTAQYKKICPHGPGYTTDG----------RDIDECKVMPN-LCTNGQCINTMGS 2471
              CP+  +A++  +CP G GYT D           RDIDEC +  + +C  G+C+NT   
Sbjct: 957  YPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPG 1016

Query: 2472 FRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCK 2531
            + C+CK G+  D +   C+D+DEC       N +C+NT G Y+C+C          + C 
Sbjct: 1017 YECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCL 1076

Query: 2532 DLDECQT---------KQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLC 2582
              +E +           Q     +C   L G      P  T     C      G+Q   C
Sbjct: 1077 SPEEMERAPERRDVCWSQRGEDGMCAGPLAG------PALTFDDCCCRQGRGWGAQCRPC 1130

Query: 2583 GAKGICQNTPGSFSCECQRGFSLDATGL-----------NCEDVDECDGNHRCQHG-CQN 2630
              +G   + P S S   +     D + L           + ED DEC    RC  G C  
Sbjct: 1131 PPRGAGSHCPTSQS---ESNSFWDTSPLLLGKPPRDEDSSEEDSDEC----RCVSGRCVP 1183

Query: 2631 ILGGYRCGCPQGYIQHYQWNQCVDENECSNPN----ACGSASCYNTLGSYKCACPSGFSF 2686
              GG  C CP G+       +CVD +EC   N     C S  C NT GS++C C +GF+ 
Sbjct: 1184 RPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFAR 1243

Query: 2687 DQFSSAC 2693
             +   AC
Sbjct: 1244 SRPHGAC 1250



 Score =  334 bits (856), Expect = 9e-91
 Identities = 217/698 (31%), Positives = 299/698 (42%), Gaps = 122/698 (17%)

Query: 1800 DIHTGKAVDIDECKEIPGICAN-------------------------------------- 1821
            +I   +  + DEC+    IC +                                      
Sbjct: 566  EIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPC 625

Query: 1822 ----GVCINQIGSFRCECPTGFSYNDLL--LVCEDIDECSNGDNLCQRNADCINSPGSYR 1875
                G+C+N  GS+ C C  G+  +       C D++EC+   +LC     CIN PG Y+
Sbjct: 626  GPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYK 684

Query: 1876 CECAAGFKL--SPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCI-CHNGFKASQDQTMC 1932
            C C  G++L  S    C D +EC + P+ C  G C +  GS++CI C  G++ SQ    C
Sbjct: 685  CNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKPGSFKCIACQPGYR-SQGGGAC 742

Query: 1933 MDVDEC-ERHPCGNGTCKNTVGSYNCLCYPGF-ELTHNNDCLDIDECSSFFGQVCRNGRC 1990
             DV+EC E  PC  G C+N  GS+ C C  G+        CLD+DEC +  G VC NG C
Sbjct: 743  RDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA--GDVCDNGIC 800

Query: 1991 FNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYE-V 2049
             N  GSF+C C  GY L+ D  +C D +EC   P +C  G C N  GS+RC+CP G+  V
Sbjct: 801  SNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDCINTNGSYRCLCPQGHRLV 859

Query: 2050 KSENCIDINECDEDPNICL-FGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSF----C 2104
                C DI+EC +DP++CL  G+C N  G + C+C  GF  + +   C +  Q      C
Sbjct: 860  GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKEC 919

Query: 2105 FTNFENGK-CSVPKAFNTTKAKCCCSKMPGEGWGDPCEL--CPKDDEVAFQDLCPYGHGT 2161
            + NF++   C    A N T+ +CCCS   G GWGD CE+  CP      F  LCP G G 
Sbjct: 920  YLNFDDTVFCDSVLATNVTQQECCCSL--GAGWGDHCEIYPCPVYSSAEFHSLCPDGKGY 977

Query: 2162 VPSLH------DTREDVNEC-LESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDT 2214
                +          D++EC L    IC  G+C+NT   + C C  G+  D   + CVD 
Sbjct: 978  TQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDV 1037

Query: 2215 DECSIGNPCGNGTCTNVIGSFECNCNEGFEPGP-MMNCEDINECAQNPL----------- 2262
            DEC   + C NG C N  G + C C    E  P    C    E  + P            
Sbjct: 1038 DECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGE 1097

Query: 2263 --LCAFRCMNTFGSY-ECTCPIGYALREDQKMC--------------------------- 2292
              +CA        ++ +C C  G       + C                           
Sbjct: 1098 DGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLL 1157

Query: 2293 ----KDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECR---TK 2345
                +D D   E   +C      C    G  +C CP G         CVD +ECR    +
Sbjct: 1158 GKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1217

Query: 2346 PGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQ 2383
              +C++ RCVN  GS+RC C  GF  S     C+  R+
Sbjct: 1218 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRR 1255



 Score =  296 bits (758), Expect = 2e-79
 Identities = 216/724 (29%), Positives = 296/724 (40%), Gaps = 171/724 (23%)

Query: 1892 DRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCG--NGTCK 1949
            + +EC    N+C HG CV     Y C C+ G+++      C+DV+ECE  PCG   G C 
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633

Query: 1950 NTVGSYNCLCYPGFEL---THNNDCLDIDECSSFFGQVCRNGR-CFNEIGSFKCLCNEGY 2005
            NT GSYNC C  G+ L        C+D++EC+     +C +G  C N  G +KC C  GY
Sbjct: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK--PHLCGDGGFCINFPGHYKCNCYPGY 691

Query: 2006 ELTPDGKN-CIDTNECVALPGSCSPGTCQNLEGSFRCI-CPPGYEVKSEN-CIDINECDE 2062
             L       C D +EC   P SC  G C+N  GSF+CI C PGY  +    C D+NEC E
Sbjct: 692  RLKASRPPVCEDIDECRD-PSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAE 750

Query: 2063 DPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTT 2122
              + C  G C N PG F+C C  G+  + +GR C D  +       +NG           
Sbjct: 751  G-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNG----------- 798

Query: 2123 KAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTR-----EDVNECLE 2177
                 CS  PG                +FQ  C  G+      H +R     ED++EC +
Sbjct: 799  ----ICSNTPG----------------SFQCQCLSGY------HLSRDRSHCEDIDEC-D 831

Query: 2178 SPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPC--GNGTCTNVIGSF 2235
             P  C  G CINT+GS+RC CP G+ L   G +C D DECS        +G C N+ GS+
Sbjct: 832  FPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSY 890

Query: 2236 ECNCNEGFEPGPMMN-CEDIN------ECAQN---PLLCAFRCMNTFGSYECTCPIG--- 2282
             C C+EGF P    + CE++       EC  N    + C           EC C +G   
Sbjct: 891  VCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGW 950

Query: 2283 -----------YALREDQKMC--------------------KDLDECAE-GLHDCESRGM 2310
                       Y+  E   +C                    +D+DEC   G   C+    
Sbjct: 951  GDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEG-- 1008

Query: 2311 MCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQ 2370
             C N    + C C  G     +   CVD +EC  +   C NG C N  G YRC C    +
Sbjct: 1009 KCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN-CRNGVCENTRGGYRCACTPPAE 1067

Query: 2371 SSSSGTECLD--------NRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQC 2422
             S +  +CL          R+ +C+++  +        +   +T  +CCC  GRGWG QC
Sbjct: 1068 YSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQC 1127

Query: 2423 ELCPLPGTAQY------------------------------------------------K 2434
              CP  G   +                                                 
Sbjct: 1128 RPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGG 1187

Query: 2435 KICPHGPGYTTDGR-----DIDECKVMPN---LCTNGQCINTMGSFRCFCKVGYTTDISG 2486
             +C    G+  D       DIDEC+ +     LC + +C+NT GSFRC CK G+      
Sbjct: 1188 AVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPH 1247

Query: 2487 TSCI 2490
             +C+
Sbjct: 1248 GACV 1251



 Score =  291 bits (744), Expect = 8e-78
 Identities = 216/734 (29%), Positives = 299/734 (40%), Gaps = 186/734 (25%)

Query: 1930 TMCMDVDECE--RHPCGNGTCKNTVGSYNCLCYPGFEL-THNNDCLDIDECSSFFGQVCR 1986
            T   + DEC   ++ CG+G C      Y+C C PG+     +  C+D++EC +   + C 
Sbjct: 570  TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA---EPCG 626

Query: 1987 NGR--CFNEIGSFKCLCNEGYELT--PDGKNCIDTNECVALPGSCSPGT-CQNLEGSFRC 2041
             GR  C N  GS+ C CN GY L     G++C+D NEC A P  C  G  C N  G ++C
Sbjct: 627  PGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKC 685

Query: 2042 ICPPGYEVKSEN---CIDINECDEDPNICLFGSCTNTPGGFQCL-CPPGFVLSDNGRRCF 2097
             C PGY +K+     C DI+EC  DP+ C  G C N PG F+C+ C PG+  S  G  C 
Sbjct: 686  NCYPGYRLKASRPPVCEDIDEC-RDPSSCPDGKCENKPGSFKCIACQPGY-RSQGGGACR 743

Query: 2098 DTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPY 2157
            D  +       E   CS                    GW   CE  P     +F+  C  
Sbjct: 744  DVNECA-----EGSPCS-------------------PGW---CENLPG----SFRCTCAQ 772

Query: 2158 GHGTVPSLHDTRE--DVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTD 2215
            G+   P   D R   DV+EC E+  +C NG C NT GSF+C+C  GY+L      C D D
Sbjct: 773  GYAPAP---DGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDID 828

Query: 2216 ECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCA--FRCMNTFG 2273
            EC     C  G C N  GS+ C C +G        C+DI+EC+Q+P LC     C N  G
Sbjct: 829  ECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQG 888

Query: 2274 SYECTCPIGYALREDQKMCKDLD------ECAEGLHDCESRGMMCKNLIGTFM----CIC 2323
            SY C C  G+   +DQ  C++++      EC     D     + C +++ T +    C C
Sbjct: 889  SYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDT----VFCDSVLATNVTQQECCC 944

Query: 2324 PPGM--------------------ARRPDGEGCVDEN--------------ECRT-KPGI 2348
              G                     +  PDG+G   +N              EC      I
Sbjct: 945  SLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEI 1004

Query: 2349 CENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTIC------------- 2395
            C+ G+CVN    Y C C +GF    +  EC+D  + L  +     +C             
Sbjct: 1005 CKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTP 1064

Query: 2396 -----------------QMASSSRNL-------------------VTKSECCCDGGRGWG 2419
                             + A   R++                   +T  +CCC  GRGWG
Sbjct: 1065 PAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWG 1124

Query: 2420 HQCELCPLPGTAQYKKICPHGPGYT-------------------TDGRDIDECKVMPNLC 2460
             QC  CP  G   +   CP     +                   +   D DEC+     C
Sbjct: 1125 AQCRPCPPRGAGSH---CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----C 1176

Query: 2461 TNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDEC---SQSPKPC-NYICKNTEGSYQCS 2516
             +G+C+   G   C C  G+  D S   C+D+DEC   +Q    C +  C NT GS++C 
Sbjct: 1177 VSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCV 1236

Query: 2517 CPRGYVLQEDGKTC 2530
            C  G+        C
Sbjct: 1237 CKAGFARSRPHGAC 1250



 Score =  288 bits (737), Expect = 5e-77
 Identities = 213/715 (29%), Positives = 292/715 (40%), Gaps = 168/715 (23%)

Query: 1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGT-- 1707
            + DEC+    +C  G C+     + C C  GY      R C D++EC A P  CGPG   
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP--CGPGRGI 631

Query: 1708 CYNTLGNYTCICPPEY-MQVN-GGHNCMDMRKSFCYRSY---NGTTCENELPFNVTKRMC 1762
            C NT G+Y C C   Y + V  GG +C+D+ +  C + +   +G  C N  P +  K  C
Sbjct: 632  CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNE--CAKPHLCGDGGFCIN-FPGHY-KCNC 687

Query: 1763 CCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANG 1822
               Y +  +    CE                              DIDEC++ P  C +G
Sbjct: 688  YPGYRLKASRPPVCE------------------------------DIDECRD-PSSCPDG 716

Query: 1823 VCINQIGSFRC-ECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAG 1881
             C N+ GSF+C  C  G+        C D++EC+ G         C N PGS+RC CA G
Sbjct: 717  KCENKPGSFKCIACQPGYRSQGGG-ACRDVNECAEGSPCSP--GWCENLPGSFRCTCAQG 773

Query: 1882 FKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECE- 1939
            +  +P+G +C+D +EC E  +VC +G+C +  GS+QC C +G+  S+D++ C D+DEC+ 
Sbjct: 774  YAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDF 832

Query: 1940 RHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKC 1999
               C  G C NT GSY CLC  G  L     C DIDECS        +G C N  GS+ C
Sbjct: 833  PAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC 892

Query: 2000 LCNEGYELTPDGKNC-----------------------------IDTNECVALPGSCSPG 2030
            +C+EG+  T D   C                             +   EC    G+    
Sbjct: 893  VCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGD 952

Query: 2031 TCQ------NLEGSFRCICPPGYEVKSENCI---------DINECD-EDPNICLFGSCTN 2074
             C+           F  +CP G     +N I         DI+EC      IC  G C N
Sbjct: 953  HCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVN 1012

Query: 2075 TPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENG-----------KCSVPKAFNTTK 2123
            T  G++C C  GF    N   C D  +    +N  NG            C+ P  ++  +
Sbjct: 1013 TQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQ 1072

Query: 2124 AKC---------------------------------------CCSKMPGEGWGDPCELCP 2144
             +C                                       CC +  G GWG  C  CP
Sbjct: 1073 RQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQ-GRGWGAQCRPCP 1131

Query: 2145 -----------KDDEVAFQDLCPYGHGTVPSLHD-TREDVNECLESPGICSNGQCINTDG 2192
                       + +  +F D  P   G  P   D + ED +EC      C +G+C+   G
Sbjct: 1132 PRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPG 1186

Query: 2193 SFRCECPMGYNLDYTGVRCVDTDEC----SIGNPCGNGTCTNVIGSFECNCNEGF 2243
               CECP G+ LD +  RCVD DEC      G  C +  C N  GSF C C  GF
Sbjct: 1187 GAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241



 Score =  285 bits (729), Expect = 5e-76
 Identities = 186/590 (31%), Positives = 255/590 (43%), Gaps = 120/590 (20%)

Query: 493  QTIDICKHHANLCLNGRCIPTVSSYRC-ECNMGYKQDANGDCIDVDECTS-NPCTNGDCV 550
            + ID C+  ++ C +G+C     S++C  C  GY+    G C DV+EC   +PC+ G C 
Sbjct: 702  EDIDECRDPSS-CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCE 760

Query: 551  NTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTT 610
            N PGS+ C C  G+   P  ++C+D+DEC + G +C NG C NT GSFQC C +G+ L+ 
Sbjct: 761  NLPGSFRCTCAQGYAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSR 819

Query: 611  DGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDEC-QTPGICM 669
            D  +C D DEC     C+ G CIN +GS++C+C  G  L   GR C D+DEC Q P +C+
Sbjct: 820  DRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCL 878

Query: 670  -NGHCINSEGSFRCDCPPGLAVGMDGRVCVDT---HMRSTCYGGIKKGV-CVRPFPGAVT 724
             +G C N +GS+ C C  G     D   C +    H +  CY      V C       VT
Sbjct: 879  PHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVT 938

Query: 725  KSECCCANPDYGFGEPCQ--PCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANG 782
            + ECCC+    G+G+ C+  PCP  +SAEFH LC  G G T D   +N           G
Sbjct: 939  QQECCCSL-GAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNY----------G 987

Query: 783  ICENLRGSYRCNCNSGYEPDASGRNCIDIDECLV-NRLLCDNGLCRNTPGSYSCTCPPGY 841
            I  +                       DIDEC++    +C  G C NT   Y C C  G+
Sbjct: 988  IPAHR----------------------DIDECMLFGSEICKEGKCVNTQPGYECYCKQGF 1025

Query: 842  VFRTETETCEDINEC--ESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICID------- 892
             +      C D++EC  ESN C NG C N  G + C C+P ++ S     C+        
Sbjct: 1026 YYDGNLLECVDVDECLDESN-CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERA 1084

Query: 893  -SLKGTCWLNI-QDSRCEVNINGATLK-SECCATLGAAWGSPCERCELDTA---CP---- 942
               +  CW    +D  C   + G  L   +CC   G  WG+ C  C    A   CP    
Sbjct: 1085 PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQS 1144

Query: 943  -----------------------------------RGLARIKGVTCE------------- 954
                                               R + R  G  CE             
Sbjct: 1145 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRAR 1204

Query: 955  --DVNECEVFPG---VCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIR 999
              D++EC        +C + RCVN+ GSF C C  G         C+  R
Sbjct: 1205 CVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQR 1254



 Score =  276 bits (706), Expect = 2e-73
 Identities = 209/711 (29%), Positives = 295/711 (41%), Gaps = 145/711 (20%)

Query: 943  RGLARIKGVTCEDVNECEVFPGVCPNGRCV------------------------------ 972
            R    I      + +EC +   +C +G CV                              
Sbjct: 562  RSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECE 621

Query: 973  ------------NSKGSFHCECPEG--LTLDGTGRVCLDI-RMEQCYLKWDEDECIHPVP 1017
                        N+ GS++C C  G  L +   GR C+D+    + +L  D   CI+  P
Sbjct: 622  AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCIN-FP 680

Query: 1018 GKFRMDACCCAVG----AAWGTECE---ECPKPGTKEYETLCPRGAGFANRGD--VLTGR 1068
            G ++   C C  G    A+    CE   EC  P +      CP G      G    +  +
Sbjct: 681  GHYK---CNCYPGYRLKASRPPVCEDIDECRDPSS------CPDGKCENKPGSFKCIACQ 731

Query: 1069 PFY--------KDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECR 1120
            P Y        +D+NEC A    C+ G C N  GSF+C C  G+A   + R+C D+DEC 
Sbjct: 732  PGYRSQGGGACRDVNEC-AEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECE 790

Query: 1121 ISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGS 1180
             + D+C +GIC NTPGSF+C+C  GY        +C DIDEC+  P  C GG C+NT GS
Sbjct: 791  -AGDVCDNGICSNTPGSFQCQCLSGYHLS-RDRSHCEDIDECD-FPAACIGGDCINTNGS 847

Query: 1181 FQCDCPLGHELSPSREDCVDINECSLSDNLC-RNGKCVNMIGTYQCSCNPGYQATPDRQG 1239
            ++C CP GH L   R+ C DI+ECS   +LC  +G C N+ G+Y C C+ G+  T D+ G
Sbjct: 848  YRCLCPQGHRLVGGRK-CQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHG 906

Query: 1240 CTDID------ECMIMNGG---CDTQCTNSEGSYECSCSEG------------------- 1271
            C +++      EC +       CD+    +    EC CS G                   
Sbjct: 907  CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE 966

Query: 1272 -YALMPDGRSCA--------------DIDECE-NNPDICDGGQCTNIPGEYRCLCYDGFM 1315
             ++L PDG+                 DIDEC     +IC  G+C N    Y C C  GF 
Sbjct: 967  FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFY 1026

Query: 1316 ASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGA 1375
               ++  C+DV+EC L+ + C  G CENT+G + C C            C   +E E   
Sbjct: 1027 YDGNLLECVDVDEC-LDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAP 1085

Query: 1376 HNCDMHASCLNIPGSF------------KCSCREGWIGNGIKCIDLDECSNGTHQCSINA 1423
               D+  S     G               C CR+G  G G +C        G+H  +  +
Sbjct: 1086 ERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQG-RGWGAQCRPCPPRGAGSHCPTSQS 1144

Query: 1424 QCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPA 1483
            +  +   +      +    +  +  D DEC      C +G+C+  PG   CEC  GF   
Sbjct: 1145 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLD 1199

Query: 1484 SDSRSCQDIDECSFQN----ICVFGTCNNLPGMFHCICDDGYELDRTGGNC 1530
            +    C DIDEC   N    +C    C N  G F C+C  G+   R  G C
Sbjct: 1200 ASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250



 Score =  245 bits (625), Expect = 5e-64
 Identities = 203/731 (27%), Positives = 279/731 (38%), Gaps = 162/731 (22%)

Query: 768  DINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCR 827
            + +EC L+ +IC +G C      Y C+CN GY      R C+D++EC         G+C 
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633

Query: 828  NTPGSYSCTCPPGYVFRTET--ETCEDINEC-ESNPCVNGA-CRNNLGSFNCECSPGSKL 883
            NT GSY+C C  GY         +C D+NEC + + C +G  C N  G + C C PG +L
Sbjct: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRL 693

Query: 884  -SSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACP 942
             +S   +C D  +     +  D +CE N  G+                   +C    AC 
Sbjct: 694  KASRPPVCEDIDECRDPSSCPDGKCE-NKPGSF------------------KC---IACQ 731

Query: 943  RGLARIKGVTCEDVNEC-EVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRME 1001
             G     G  C DVNEC E  P  C  G C N  GSF C C +G      GR CLD+   
Sbjct: 732  PGYRSQGGGACRDVNECAEGSP--CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDEC 789

Query: 1002 QCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANR 1061
            +     D   C +  PG F+   C C  G     +   C                     
Sbjct: 790  EAGDVCDNGICSN-TPGSFQ---CQCLSGYHLSRDRSHC--------------------- 824

Query: 1062 GDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRI 1121
                      +DI+EC  FP  C  G C NT GS++C C  G  L +  R C DIDEC  
Sbjct: 825  ----------EDIDECD-FPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQ 872

Query: 1122 SPDLC-GSGICVNTPGSFECECFEGYESGFMMMKNCMDID------ECERN---PLLCRG 1171
             P LC   G C N  GS+ C C EG+ +       C +++      EC  N    + C  
Sbjct: 873  DPSLCLPHGACKNLQGSYVCVCDEGF-TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDS 931

Query: 1172 GTCVNTEGSFQCDCPLG--------------------HELSPSREDCV------------ 1199
                N     +C C LG                    H L P  +               
Sbjct: 932  VLATNVTQQ-ECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPA 990

Query: 1200 --DINECSL-SDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQ 1256
              DI+EC L    +C+ GKCVN    Y+C C  G+    +   C D+DEC+  +   +  
Sbjct: 991  HRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGV 1050

Query: 1257 CTNSEGSYECSCSEGYALMPDGRSCADIDECENNP---DIC-----DGGQCTN-IPGEY- 1306
            C N+ G Y C+C+      P  R C   +E E  P   D+C     + G C   + G   
Sbjct: 1051 CENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPAL 1110

Query: 1307 ---RCLCYDGFMASMDMKTC---------------------------------IDVNECD 1330
                C C  G       + C                                  D +E D
Sbjct: 1111 TFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEED 1170

Query: 1331 LNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDEC-EIGAHNCDMHAS-CLNIP 1388
             +   C+ G C    G  +C C  G+ +      C D+DEC E+        +  C+N  
Sbjct: 1171 SDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTS 1230

Query: 1389 GSFKCSCREGW 1399
            GSF+C C+ G+
Sbjct: 1231 GSFRCVCKAGF 1241



 Score =  240 bits (613), Expect = 1e-62
 Identities = 171/539 (31%), Positives = 219/539 (40%), Gaps = 91/539 (16%)

Query: 2253 DINECAQNPLLCAF-RCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMM 2311
            + +EC  N  +C    C+     Y C C  GY      + C D++EC      C     +
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA--EPCGPGRGI 631

Query: 2312 CKNLIGTFMCICPPGMARR--PDGEGCVDENECRTKPGIC-ENGRCVNIIGSYRCECNEG 2368
            C N  G++ C C  G        G  CVD NEC  KP +C + G C+N  G Y+C C  G
Sbjct: 632  CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPG 690

Query: 2369 FQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLP 2428
            ++  +S                   +C+     R+       C DG      +CE  P  
Sbjct: 691  YRLKASRPP----------------VCEDIDECRD----PSSCPDG------KCENKP-- 722

Query: 2429 GTAQYKKICPHGPGYTTDG----RDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDI 2484
                +K I    PGY + G    RD++EC    + C+ G C N  GSFRC C  GY    
Sbjct: 723  --GSFKCIACQ-PGYRSQGGGACRDVNEC-AEGSPCSPGWCENLPGSFRCTCAQGYAPAP 778

Query: 2485 SGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQ 2544
             G SC+D+DEC       N IC NT GS+QC C  GY L  D   C+D+DEC        
Sbjct: 779  DGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIG 838

Query: 2545 FLCVNTLGGFTCKCPPGFTQ-HHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGF 2603
              C+NT G + C CP G        C D +EC   PSLC   G C+N  GS+ C C  GF
Sbjct: 839  GDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898

Query: 2604 SLDATGLNCEDVDECDGNHRC-------------------QHGCQNILGG--------YR 2636
            +       CE+V++      C                   Q  C   LG         Y 
Sbjct: 899  TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP 958

Query: 2637 CG----------CP--QGYIQ-----HYQWNQCVDENECS--NPNACGSASCYNTLGSYK 2677
            C           CP  +GY Q     +Y      D +EC       C    C NT   Y+
Sbjct: 959  CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYE 1018

Query: 2678 CACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGC-PPGYYRVGQGHCVS 2735
            C C  GF +D     C DV+EC    N  N  C NT GGY C C PP  Y   Q  C+S
Sbjct: 1019 CYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLS 1077



 Score =  236 bits (602), Expect = 2e-61
 Identities = 174/591 (29%), Positives = 245/591 (41%), Gaps = 57/591 (9%)

Query: 2179 PGICSNGQCINTDGSF--RCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFE 2236
            PG+     C  + G+   + +C     L YTGV+                    V G   
Sbjct: 295  PGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGP----------------VRGEVG 338

Query: 2237 CNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMC-KDL 2295
             +C +G++     +C+DINECA   +     C+N  GSY C CP G++L   +  C  D 
Sbjct: 339  ADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398

Query: 2296 DECAEGLHDCESRGMMCKNLIGTFM----CICPPGMARRPDGEGCVDENECRTKPGICEN 2351
             E         S    C++ + T +    C C  G A     + C  +     K  IC  
Sbjct: 399  PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKE-ICPA 457

Query: 2352 GRCVNIIGSYRCECNEGFQSSSS--GTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSE 2409
            G+  +I+ S++    +G    S     +     Q L  +       +     R + T S 
Sbjct: 458  GKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSP 517

Query: 2410 CCCDGGRGWGHQC----------ELCPLPGTAQYKKICPHGPGYT-------TDGRDIDE 2452
               +      H            EL   P     +   P  P          T   + DE
Sbjct: 518  VSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDE 577

Query: 2453 CKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSP-KPCNYICKNTEG 2511
            C++  N+C +G+C+     + C C  GY +      C+D++EC   P  P   IC NT G
Sbjct: 578  CRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGG 637

Query: 2512 SYQCSCPRGYVLQ--EDGKTCKDLDECQTKQHNCQF--LCVNTLGGFTCKCPPGF---TQ 2564
            SY C C RGY L     G++C DL+EC  K H C     C+N  G + C C PG+     
Sbjct: 638  SYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 696

Query: 2565 HHTACIDNNECGSQPSLCGAKGICQNTPGSFSC-ECQRGFSLDATGLNCEDVDECDGNHR 2623
                C D +EC   PS C   G C+N PGSF C  CQ G+     G  C DV+EC     
Sbjct: 697  RPPVCEDIDEC-RDPSSC-PDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSP 753

Query: 2624 CQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPS 2682
            C  G C+N+ G +RC C QGY        C+D +EC   + C +  C NT GS++C C S
Sbjct: 754  CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLS 813

Query: 2683 GFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHC 2733
            G+   +  S C D++EC          C NT G Y C CP G+  VG   C
Sbjct: 814  GYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKC 864



 Score =  230 bits (586), Expect = 2e-59
 Identities = 206/737 (27%), Positives = 280/737 (37%), Gaps = 153/737 (20%)

Query: 181  ENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQ-VNNQMCQGQLTGIVCTKTLC 239
            +N C +G    GP   +C        C   YR+ P     V+   C+ +  G    + +C
Sbjct: 582  QNICGHGECVPGPPDYSC-------HCNPGYRSHPQHRYCVDVNECEAEPCGP--GRGIC 632

Query: 240  CATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTG--ACQDVDECQAIPGIC-QGGNCINTV 296
              T G    H           C RG+  ++  G  +C D++EC A P +C  GG CIN  
Sbjct: 633  MNTGGSYNCH-----------CNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFP 680

Query: 297  GSFECRCPAGHK-QSETTQKCEDIDECSIIPGICETGECSNTVGSYFCV-CPRGYVTSTD 354
            G ++C C  G++ ++     CEDIDEC   P  C  G+C N  GS+ C+ C  GY  S  
Sbjct: 681  GHYKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKPGSFKCIACQPGY-RSQG 738

Query: 355  GSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYR 414
            G  C D          VN  CA+  P         C PG C                   
Sbjct: 739  GGACRD----------VN-ECAEGSP---------CSPGWC------------------- 759

Query: 415  RLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGA 474
                       +PGS       T   G+AP+ +G                NG      G+
Sbjct: 760  ---------ENLPGSFRC----TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGS 806

Query: 475  GVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCI 534
                   G  ++      + ID C   A  C+ G CI T  SYRC C  G++      C 
Sbjct: 807  FQCQCLSGYHLSRDRSHCEDIDECDFPA-ACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ 865

Query: 535  DVDECTSNPCT---NGDCVNTPGSYYCKCHAGFQRTPTKQACIDID------ECIQN--- 582
            D+DEC+ +P     +G C N  GSY C C  GF  T  +  C +++      EC  N   
Sbjct: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDD 925

Query: 583  GVLCKNGRCVNTDGSFQCICNAG--------------------FELTTDGKNCV------ 616
             V C +    N     +C C+ G                      L  DGK         
Sbjct: 926  TVFCDSVLATNVTQQ-ECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIV 984

Query: 617  --------DHDECTT--TNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPG 666
                    D DEC    + +C  G C+N    ++C CK GF    N   C DVDEC    
Sbjct: 985  NYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDES 1044

Query: 667  ICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVD-------THMRSTCYGGI-KKGVCVRP 718
             C NG C N+ G +RC C P        R C+           R  C+    + G+C  P
Sbjct: 1045 NCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGP 1104

Query: 719  FPGAVTKSECCCANPDYGFGEPCQPCPAK-----------NSAEFHGLCSSGVGITVDGR 767
              G     + CC     G+G  C+PCP +            S  F       +G      
Sbjct: 1105 LAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDE 1164

Query: 768  DINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL-VNR--LLCDNG 824
            D +E   D   C +G C    G   C C  G++ DAS   C+DIDEC  +N+  LLC + 
Sbjct: 1165 DSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSE 1224

Query: 825  LCRNTPGSYSCTCPPGY 841
             C NT GS+ C C  G+
Sbjct: 1225 RCVNTSGSFRCVCKAGF 1241



 Score =  208 bits (529), Expect = 7e-53
 Identities = 207/807 (25%), Positives = 291/807 (36%), Gaps = 211/807 (26%)

Query: 26   TAGQPQPPPPKPPRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLR- 84
            T    +P P    RP PP  +           +  P+     +AV     +  + D  R 
Sbjct: 532  TTTPARPYPELISRPSPPTMR-----------WFLPDLPPSRSAVEIAPTQVTETDECRL 580

Query: 85   GPNVCGSR--------FHSYCCPGWKTLPGGNQCI-VPICR-NSCGDG--FCSRPN---M 129
              N+CG          +  +C PG+++ P    C+ V  C    CG G   C        
Sbjct: 581  NQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYN 640

Query: 130  CTCSSG-QISSTCGSKS---IQQCSVR--CMNGGTCADD----HCQCQKGYIGTYCGQPV 179
            C C+ G ++    G +S   + +C+    C +GG C +      C C  GY       PV
Sbjct: 641  CHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPV 700

Query: 180  CEN-------------GCQN------------------GGRCIGPNRCA----CVYGFTG 204
            CE+              C+N                  GG C   N CA    C  G+  
Sbjct: 701  CEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCE 760

Query: 205  P-------QCERDYRTGPCFTQ-VNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPA 256
                     C + Y   P     ++   C+    G VC   +C  T G      C+    
Sbjct: 761  NLPGSFRCTCAQGYAPAPDGRSCLDVDECE---AGDVCDNGICSNTPG---SFQCQ---- 810

Query: 257  QPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKC 316
                C  G+  +     C+D+DEC   P  C GG+CINT GS+ C CP GH+     +KC
Sbjct: 811  ----CLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTNGSYRCLCPQGHR-LVGGRKC 864

Query: 317  EDIDECSIIPGIC-ETGECSNTVGSYFCVCPRGYVTSTDGSRCID----QRTGMCFSGLV 371
            +DIDECS  P +C   G C N  GSY CVC  G+  + D   C +         C+    
Sbjct: 865  QDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFD 924

Query: 372  NG-RCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSA 430
            +   C   L   +T+ +CCC  G  WG       CPV  S E+  LC D           
Sbjct: 925  DTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPD----------- 973

Query: 431  GSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTI 490
                    G G+    N   YG        IP                            
Sbjct: 974  --------GKGYTQDNNIVNYG--------IPA--------------------------- 990

Query: 491  LNQTIDICK-HHANLCLNGRCIPTVSSYRCECNMGYKQDAN-GDCIDVDEC-TSNPCTNG 547
             ++ ID C    + +C  G+C+ T   Y C C  G+  D N  +C+DVDEC   + C NG
Sbjct: 991  -HRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG 1049

Query: 548  DCVNTPGSYYCKCHAGFQRTPTKQACI---DIDECIQNGVLC-----KNGRCVNTDGS-- 597
             C NT G Y C C    + +P ++ C+   +++   +   +C     ++G C        
Sbjct: 1050 VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPA 1109

Query: 598  ---FQCIC----------------NAGFELTTD---------------GKNCVDHD---E 620
                 C C                 AG    T                GK   D D   E
Sbjct: 1110 LTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEE 1169

Query: 621  CTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDEC----QTPGICMNGHCINS 676
             +    C++G C+   G   C C  GF L  +   C D+DEC    Q   +C +  C+N+
Sbjct: 1170 DSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNT 1229

Query: 677  EGSFRCDCPPGLAVGMDGRVCVDTHMR 703
             GSFRC C  G A       CV    R
Sbjct: 1230 SGSFRCVCKAGFARSRPHGACVPQRRR 1256



 Score =  130 bits (328), Expect = 1e-29
 Identities = 60/167 (35%), Positives = 90/167 (53%), Gaps = 22/167 (13%)

Query: 913  GATLKSECCATLGAAWG-SPCERC----------------ELDTACPRGLARIKGVTCED 955
            G T + +CC ++G AWG S C +C                E+   CP+G  R+    C+D
Sbjct: 296  GLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQD 355

Query: 956  VNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQ---CY-LKWDEDE 1011
            +NEC + PGVC +G C+N+ GS+ C CP G +L  +   C+  + E+   C+ L   E +
Sbjct: 356  INECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQ 414

Query: 1012 CIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGF 1058
            C HP+  +     CCC+VG AWG  C+ CP  GT  ++ +CP G G+
Sbjct: 415  CQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGY 461



 Score = 97.4 bits (241), Expect = 2e-19
 Identities = 59/188 (31%), Positives = 87/188 (46%), Gaps = 38/188 (20%)

Query: 239 CCATIGRAWGHP-CEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVG 297
           CC +IG AWG   C  CP                             G+ + G     VG
Sbjct: 303 CCGSIGTAWGQSKCHKCPQLQYT------------------------GVQKPGPVRGEVG 338

Query: 298 SFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSR 357
           +    CP G+K+  +T  C+DI+EC++ PG+C  G+C N  GSY CVCP G+      ++
Sbjct: 339 A---DCPQGYKRLNSTH-CQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393

Query: 358 CI---DQRTGMCFSGLVN--GRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEE 412
           CI    +   +CF  LV+   +C   L  R+T+  CCC  G+ WG     + CP  G+  
Sbjct: 394 CIADKPEEKSLCFR-LVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARC--QRCPTDGTAA 450

Query: 413 YRRLCMDG 420
           ++ +C  G
Sbjct: 451 FKEICPAG 458



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 44/138 (31%), Positives = 68/138 (49%), Gaps = 13/138 (9%)

Query: 652 NGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCV--DTHMRSTCYGG 709
           N  +C D++EC  PG+C +G C+N+ GS+RC CPPG ++G     C+      +S C+  
Sbjct: 349 NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRL 408

Query: 710 IK-KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVG------- 761
           +  +  C  P    +T+  CCC +    +G  CQ CP   +A F  +C +G G       
Sbjct: 409 VSPEHQCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSH 467

Query: 762 --ITVDGRDINECALDPD 777
             +T+ G       L PD
Sbjct: 468 QTLTIQGESDFSLFLHPD 485



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 48/160 (30%), Positives = 70/160 (43%), Gaps = 40/160 (25%)

Query: 2001 CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINEC 2060
            C +GY+   +  +C D NEC A+PG C  G C N  GS+RC+CPPG+ +       I + 
Sbjct: 341  CPQGYKRL-NSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398

Query: 2061 DEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFN 2120
             E+ ++C           F+ + P                           +C  P    
Sbjct: 399  PEEKSLC-----------FRLVSP-------------------------EHQCQHPLTTR 422

Query: 2121 TTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHG 2160
             T+  CCCS   G+ WG  C+ CP D   AF+++CP G G
Sbjct: 423  LTRQLCCCS--VGKAWGARCQRCPTDGTAAFKEICPAGKG 460



 Score = 75.9 bits (185), Expect = 6e-13
 Identities = 43/125 (34%), Positives = 58/125 (46%), Gaps = 12/125 (9%)

Query: 831 GSYSCTCPPGYVFRTETETCEDINECES-NPCVNGACRNNLGSFNCECSPGSKLSSTGLI 889
           G     CP GY  R  +  C+DINEC     C +G C NN GS+ C C PG  L  +   
Sbjct: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393

Query: 890 CI---DSLKGTCW-LNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELD------T 939
           CI      K  C+ L   + +C+  +     +  CC ++G AWG+ C+RC  D       
Sbjct: 394 CIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKE 453

Query: 940 ACPRG 944
            CP G
Sbjct: 454 ICPAG 458



 Score = 66.2 bits (160), Expect = 4e-10
 Identities = 41/122 (33%), Positives = 60/122 (49%), Gaps = 12/122 (9%)

Query: 1087 GKC-RNTIGSFKCRCNSGFALDMEERNCTDI------DECRISPDLCGSGICVNTP--GS 1137
            G+C ++T+    C  N    L  +E  C  I       +C   P L  +G+    P  G 
Sbjct: 277  GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGE 336

Query: 1138 FECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSRED 1197
               +C +GY+   +   +C DI+EC   P +CR G C+N  GS++C CP GH L PSR  
Sbjct: 337  VGADCPQGYKR--LNSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393

Query: 1198 CV 1199
            C+
Sbjct: 394  CI 395



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 44/151 (29%), Positives = 65/151 (43%), Gaps = 25/151 (16%)

Query: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGH-QCELCPLPGTAQYKKICPHGP- 2441
            G CF + L      ++    L  + +CC   G  WG  +C  CP     QY  +   GP 
Sbjct: 277  GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCP---QLQYTGVQKPGPV 333

Query: 2442 ----------GY----TTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGT 2487
                      GY    +T  +DI+EC  MP +C +G C+N  GS+RC C  G++   S T
Sbjct: 334  RGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392

Query: 2488 SCIDLDECSQSPKPCNYICKNTEGSYQCSCP 2518
             CI     +  P+  +   +     +QC  P
Sbjct: 393  QCI-----ADKPEEKSLCFRLVSPEHQCQHP 418



 Score = 59.7 bits (143), Expect = 4e-08
 Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 25/129 (19%)

Query: 1774 KPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIP-----GICANGVCINQI 1828
            +PC   P PG    +  CG+I         G A    +C + P     G+   G    ++
Sbjct: 287  QPCGSNPLPGLTKQEDCCGSI---------GTAWGQSKCHKCPQLQYTGVQKPGPVRGEV 337

Query: 1829 GSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG 1888
            G+   +CP G+   +    C+DI+EC+    +C R+ DC+N+PGSYRC C  G  L P+ 
Sbjct: 338  GA---DCPQGYKRLNSTH-CQDINECAM-PGVC-RHGDCLNNPGSYRCVCPPGHSLGPS- 390

Query: 1889 ACVDRNECL 1897
                R +C+
Sbjct: 391  ----RTQCI 395



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 52/238 (21%), Positives = 84/238 (35%), Gaps = 46/238 (19%)

Query: 2631 ILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFS 2690
            + G     CPQGY +      C D NEC+ P  C    C N  GSY+C CP G S     
Sbjct: 333  VRGEVGADCPQGY-KRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391

Query: 2691 SAC-----HDVNEC---SSSKNPCNYGCSNTEGGYLC-------------GCPPGYYRVG 2729
            + C      + + C    S ++ C +  +      LC              CP       
Sbjct: 392  TQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAF 451

Query: 2730 QGHCVSGMGFN---KGQYLSLDTEVD------EENALSPEACYECKINGYSKKDSRQKRS 2780
            +  C +G G++     Q L++  E D       +    P+   E        +D+ ++R 
Sbjct: 452  KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERG 511

Query: 2781 IHEPDPTAVEQISLES---------------VDMDSPVNMKFNLSHLGSKEHILELRP 2823
            +    P + E+   +S               +   SP  M++ L  L      +E+ P
Sbjct: 512  VTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAP 569



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 24/64 (37%), Positives = 33/64 (51%), Gaps = 1/64 (1%)

Query: 512 PTVSSYRCECNMGYKQDANGDCIDVDECTS-NPCTNGDCVNTPGSYYCKCHAGFQRTPTK 570
           P       +C  GYK+  +  C D++EC     C +GDC+N PGSY C C  G    P++
Sbjct: 332 PVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391

Query: 571 QACI 574
             CI
Sbjct: 392 TQCI 395



 Score = 53.5 bits (127), Expect = 3e-06
 Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 5/80 (6%)

Query: 1868 INSPGSYRCE----CAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGF 1923
            +  PG  R E    C  G+K   +  C D NEC  +P VC HG C++  GSY+C+C  G 
Sbjct: 327  VQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA-MPGVCRHGDCLNNPGSYRCVCPPGH 385

Query: 1924 KASQDQTMCMDVDECERHPC 1943
                 +T C+     E+  C
Sbjct: 386  SLGPSRTQCIADKPEEKSLC 405



 Score = 53.1 bits (126), Expect = 4e-06
 Identities = 45/156 (28%), Positives = 66/156 (42%), Gaps = 28/156 (17%)

Query: 718 PFPGAVTKSECCCANPDYGFGEP-CQPCPAKNSAEFHGLCSSG-----VGI--------- 762
           P PG +TK E CC +    +G+  C  CP     ++ G+   G     VG          
Sbjct: 293 PLPG-LTKQEDCCGSIGTAWGQSKCHKCP---QLQYTGVQKPGPVRGEVGADCPQGYKRL 348

Query: 763 -TVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCI---DIDECLVNR 818
            +   +DINECA+ P +C +G C N  GSYRC C  G+    S   CI     ++ L  R
Sbjct: 349 NSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFR 407

Query: 819 LLCDNGLCRNTPGS----YSCTCPPGYVFRTETETC 850
           L+     C++   +      C C  G  +    + C
Sbjct: 408 LVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRC 443



 Score = 52.0 bits (123), Expect = 9e-06
 Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 2/63 (3%)

Query: 1953 GSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGK 2012
            G     C  G++  ++  C DI+EC+     VCR+G C N  GS++C+C  G+ L P   
Sbjct: 335  GEVGADCPQGYKRLNSTHCQDINECA--MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392

Query: 2013 NCI 2015
             CI
Sbjct: 393  QCI 395



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 34/90 (37%), Positives = 46/90 (51%), Gaps = 13/90 (14%)

Query: 175 CGQP-VCENG-CQNGGRCIGPNRCACVYGFT-GP---QC--ERDYRTGPCFTQVNNQ-MC 225
           C  P VC +G C N     G  RC C  G + GP   QC  ++      CF  V+ +  C
Sbjct: 359 CAMPGVCRHGDCLNNP---GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQC 415

Query: 226 QGQLTGIVCTKTLCCATIGRAWGHPCEMCP 255
           Q  LT  + T+ LCC ++G+AWG  C+ CP
Sbjct: 416 QHPLTTRL-TRQLCCCSVGKAWGARCQRCP 444



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 22/63 (34%), Positives = 33/63 (52%), Gaps = 2/63 (3%)

Query: 554 GSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGK 613
           G     C  G++R  +   C DI+EC   GV C++G C+N  GS++C+C  G  L     
Sbjct: 335 GEVGADCPQGYKRLNSTH-CQDINECAMPGV-CRHGDCLNNPGSYRCVCPPGHSLGPSRT 392

Query: 614 NCV 616
            C+
Sbjct: 393 QCI 395



 Score = 43.1 bits (100), Expect = 0.004
 Identities = 21/56 (37%), Positives = 29/56 (51%), Gaps = 2/56 (3%)

Query: 1911 LQGSYQCICHNGFKASQDQTMCMDVDECERHP-CGNGTCKNTVGSYNCLCYPGFEL 1965
            ++G     C  G+K   + T C D++EC     C +G C N  GSY C+C PG  L
Sbjct: 333  VRGEVGADCPQGYKRL-NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387



 Score = 40.0 bits (92), Expect = 0.034
 Identities = 45/164 (27%), Positives = 61/164 (37%), Gaps = 30/164 (18%)

Query: 53  GSEGGFLAPEYREEGAA---------------VASRVRR--RGQQDVLRGPNVCGSRFHS 95
           G+ GG LAPE R  GAA               +  RV     G++    G  +   RF  
Sbjct: 6   GAAGG-LAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARERFKV 64

Query: 96  YCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISS---TCGSKSIQQCSVR 152
              P    +     C+   CR+SC  G     NM        S+   T     +  C + 
Sbjct: 65  VFAP----VICKRTCLKGQCRDSCQQG----SNMTLIGENGHSTDTLTGSGFRVVVCPLP 116

Query: 153 CMNGGTCAD-DHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNR 195
           CMNGG C+  + C C   + G +C  P    G   GG   G +R
Sbjct: 117 CMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSR 160



 Score = 37.7 bits (86), Expect = 0.17
 Identities = 24/75 (32%), Positives = 30/75 (40%), Gaps = 19/75 (25%)

Query: 149 CSVRCMNGGTCADDHCQCQKGYIGTYCGQP---------------VCENGCQNGGRCIGP 193
           C   C+ G  C D    CQ+G   T  G+                VC   C NGG+C   
Sbjct: 71  CKRTCLKG-QCRDS---CQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSR 126

Query: 194 NRCACVYGFTGPQCE 208
           N+C C   FTG  C+
Sbjct: 127 NQCLCPPDFTGRFCQ 141


>gi|194328809 latent transforming growth factor beta binding protein 3
            isoform 1 [Homo sapiens]
          Length = 1303

 Score =  432 bits (1110), Expect = e-120
 Identities = 310/1044 (29%), Positives = 431/1044 (41%), Gaps = 203/1044 (19%)

Query: 1014 HPVPGKFRMDACCCAVGAAWG-TECEECP--------KPGTKEYETL--CPRGAGFANRG 1062
            +P+PG  + + CC ++G AWG ++C +CP        KPG    E    CP+G    N  
Sbjct: 292  NPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNST 351

Query: 1063 DVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRIS 1122
                     +DINEC A PG+C +G C N  GS++C C  G +L      C  I +    
Sbjct: 352  HC-------QDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC--IADKPEE 401

Query: 1123 PDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDE-----CERNPLLCRGGTCVNT 1177
              LC   +      S E +C     +       C  + +     C+R P     GT    
Sbjct: 402  KSLCFRLV------SPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPT---DGTAAFK 452

Query: 1178 EGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDR 1237
            E    C    G+ +  S +      E   S  L  +G           S  P  + T + 
Sbjct: 453  E---ICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEE 509

Query: 1238 QGCTD---IDECMIMNGGCDTQCTNSEGSYECSCSEGYAL--------MPDGRSCADI-- 1284
            +G T    + E   +     T  T     Y    S             +P  RS  +I  
Sbjct: 510  RGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAP 569

Query: 1285 ------DECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMF 1338
                  DEC  N +IC  G+C   P +Y C C  G+ +    + C+DVNEC+        
Sbjct: 570  TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR 629

Query: 1339 GECENTKGSFICHCQLGYSVKKGTTG--CTDVDECEIGAHNCDMHASCLNIPGSFKCSCR 1396
            G C NT GS+ CHC  GY +  G  G  C D++EC    H C     C+N PG +KC+C 
Sbjct: 630  GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCY 688

Query: 1397 EGWIGNGIK---CIDLDECSNGTHQCSINAQCVNTPGSYRC-ACSEGFTGDGF-TCSDVD 1451
             G+     +   C D+DEC + +  C  + +C N PGS++C AC  G+   G   C DV+
Sbjct: 689  PGYRLKASRPPVCEDIDECRDPS-SCP-DGKCENKPGSFKCIACQPGYRSQGGGACRDVN 746

Query: 1452 ECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPG 1511
            ECAE  + C  G C N+PG++RC C  G+ PA D RSC D+DEC   ++C  G C+N PG
Sbjct: 747  ECAEG-SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPG 805

Query: 1512 MFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQL------- 1564
             F C C  GY L R   +C DIDEC  P  C+ G C+NT G Y C CP   +L       
Sbjct: 806  SFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ 865

Query: 1565 ------------NPTGV-----------------------GCVD----NRVGNCYLKFGP 1585
                         P G                        GC +    +    CYL F  
Sbjct: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNF-- 923

Query: 1586 RGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCE--TCPPVNSTEYYTLCPGGEGFRPNP 1643
              D ++ C++ +   V++  CCCSLG  WG+ CE   CP  +S E+++LCP G+G+  + 
Sbjct: 924  --DDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDN 981

Query: 1644 ITI-----ILEDIDECQELPG-LCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECF 1697
              +        DIDEC      +C+ G C+NT   ++C C QG+Y   +   C D+DEC 
Sbjct: 982  NIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECL 1041

Query: 1698 ---------------------------------------------AHPGVCGPGTCYNTL 1712
                                                           P  C PG C N  
Sbjct: 1042 DESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLP 1101

Query: 1713 GNYTCICPPEYMQVNGGHNCM---------DMRKSFCY--RSYNGTTCENELPFNVTKRM 1761
            G+Y C C P ++    G +C            R+  C+  R  +G          +T   
Sbjct: 1102 GSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDD 1161

Query: 1762 CCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDI-----------HTGKAVDID 1810
            CCC    G+ W   C PCP  G         +     +D                  D D
Sbjct: 1162 CCC--RQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSD 1219

Query: 1811 ECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECS--NGDNLCQRNADCI 1868
            EC+     C +G C+ + G   CECP GF  +     C DIDEC   N   L  ++  C+
Sbjct: 1220 ECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCV 1274

Query: 1869 NSPGSYRCECAAGFKLS-PNGACV 1891
            N+ GS+RC C AGF  S P+GACV
Sbjct: 1275 NTSGSFRCVCKAGFARSRPHGACV 1298



 Score =  407 bits (1046), Expect = e-113
 Identities = 239/742 (32%), Positives = 342/742 (46%), Gaps = 90/742 (12%)

Query: 1073 DINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICV 1132
            + +EC+    +C +G+C      + C CN G+    + R C D++EC   P   G GIC+
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633

Query: 1133 NTPGSFECECFEGYESGFMMM-KNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHEL 1191
            NT GS+ C C  GY        ++C+D++EC +  L   GG C+N  G ++C+C  G+ L
Sbjct: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRL 693

Query: 1192 SPSRED-CVDINECSLSDNLCRNGKCVNMIGTYQC-SCNPGYQATPDRQGCTDIDECMIM 1249
              SR   C DI+EC    + C +GKC N  G+++C +C PGY++      C D++EC   
Sbjct: 694  KASRPPVCEDIDECR-DPSSCPDGKCENKPGSFKCIACQPGYRSQGGG-ACRDVNECAEG 751

Query: 1250 NGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCL 1309
            +      C N  GS+ C+C++GYA  PDGRSC D+DECE   D+CD G C+N PG ++C 
Sbjct: 752  SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAG-DVCDNGICSNTPGSFQCQ 810

Query: 1310 CYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVD 1369
            C  G+  S D   C D++ECD  +  C+ G+C NT GS+ C C  G+ +  G   C D+D
Sbjct: 811  CLSGYHLSRDRSHCEDIDECDFPA-ACIGGDCINTNGSYRCLCPQGHRLVGGRK-CQDID 868

Query: 1370 ECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIK--CIDLD------EC--------- 1412
            EC      C  H +C N+ GS+ C C EG+     +  C +++      EC         
Sbjct: 869  ECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVF 928

Query: 1413 ------SNGTHQ---CSINA----QC------VNTPGSYRCACSEG--FTGDGFTCS--- 1448
                  +N T Q   CS+ A     C      V +   +   C +G  +T D    +   
Sbjct: 929  CDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGI 988

Query: 1449 ----DVDECAE-NINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVF 1503
                D+DEC      +C+ G+C+N    Y C C+ GF    +   C D+DEC  ++ C  
Sbjct: 989  PAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRN 1048

Query: 1504 GTCNNLPGMFHCICDDGYELDRTGGNC-----TDIDECADPINCVNGLCVNTPGRYECNC 1558
            G C N  G + C C    E       C      D+DEC DP  C  G CVN PG Y C C
Sbjct: 1049 GVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCEC 1108

Query: 1559 PPDFQLNPTGVGC---------VDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCS 1609
             P +   P+G  C            R   C+     RG+  +      G  ++   CCC 
Sbjct: 1109 RPPWVPGPSGRDCQLPESPAERAPERRDVCW---SQRGEDGMCAGPLAGPALTFDDCCCR 1165

Query: 1610 LGKAWGNPCETCPP-----------VNSTEYYTLCPGGEGFRPNPITIILEDIDECQELP 1658
             G+ WG  C  CPP             S  ++   P   G  P       ED DEC+   
Sbjct: 1166 QGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR--- 1222

Query: 1659 GLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDEC--FAHPG-VCGPGTCYNTLGNY 1715
              C  G C+   G   CECP G+ L      C DIDEC      G +C    C NT G++
Sbjct: 1223 --CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSF 1280

Query: 1716 TCICPPEYMQVNGGHNCMDMRK 1737
             C+C   + +      C+  R+
Sbjct: 1281 RCVCKAGFARSRPHGACVPQRR 1302



 Score =  344 bits (883), Expect = 6e-94
 Identities = 236/768 (30%), Positives = 329/768 (42%), Gaps = 134/768 (17%)

Query: 2016 DTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPNICLFGSCT 2073
            +T+EC      C  G C      + C C PGY    ++  C+D+NEC+ +P     G C 
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633

Query: 2074 NTPGGFQCLCPPGFVL--SDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKM 2131
            NT G + C C  G+ L     GR C D  +           C+ P           C   
Sbjct: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNE-----------CAKPHLCGDGGF---CINF 679

Query: 2132 PGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTD 2191
            PG                 ++  C  G+    S     ED++EC + P  C +G+C N  
Sbjct: 680  PGH----------------YKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKP 722

Query: 2192 GSFRC-ECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPM-M 2249
            GSF+C  C  GY     G  C D +EC+ G+PC  G C N+ GSF C C +G+ P P   
Sbjct: 723  GSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGR 781

Query: 2250 NCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRG 2309
            +C D++EC    +     C NT GS++C C  GY L  D+  C+D+DEC          G
Sbjct: 782  SCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD---FPAACIG 838

Query: 2310 MMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGIC-ENGRCVNIIGSYRCECNEG 2368
              C N  G++ C+CP G  R   G  C D +EC   P +C  +G C N+ GSY C C+EG
Sbjct: 839  GDCINTNGSYRCLCPQGH-RLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEG 897

Query: 2369 FQSSSSGTECLDNRQGL----CFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCEL 2424
            F  +     C +  Q      C+     T+   +  + N VT+ ECCC  G GWG  CE+
Sbjct: 898  FTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATN-VTQQECCCSLGAGWGDHCEI 956

Query: 2425 --CPLPGTAQYKKICPHGPGYTTDG----------RDIDECKVMPN-LCTNGQCINTMGS 2471
              CP+  +A++  +CP G GYT D           RDIDEC +  + +C  G+C+NT   
Sbjct: 957  YPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPG 1016

Query: 2472 FRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTC- 2530
            + C+CK G+  D +   C+D+DEC       N +C+NT G Y+C+C          + C 
Sbjct: 1017 YECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCL 1076

Query: 2531 ----KDLDECQTKQHNCQFLCVNTLGGFTCKCPPGF-------------TQHHTACIDNN 2573
                 D+DECQ         CVN  G + C+C P +             +    A    +
Sbjct: 1077 SPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRD 1136

Query: 2574 ECGSQPSLCGAKGICQNTPGSFS-----CECQRGFSLDA---------TGLNC------- 2612
             C SQ    G  G+C       +     C C++G    A          G +C       
Sbjct: 1137 VCWSQR---GEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSES 1193

Query: 2613 ----------------------EDVDECDGNHRCQHG-CQNILGGYRCGCPQGYIQHYQW 2649
                                  ED DEC    RC  G C    GG  C CP G+      
Sbjct: 1194 NSFWDTSPLLLGKPPRDEDSSEEDSDEC----RCVSGRCVPRPGGAVCECPGGFQLDASR 1249

Query: 2650 NQCVDENECSNPN----ACGSASCYNTLGSYKCACPSGFSFDQFSSAC 2693
             +CVD +EC   N     C S  C NT GS++C C +GF+  +   AC
Sbjct: 1250 ARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297



 Score =  341 bits (874), Expect = 7e-93
 Identities = 210/602 (34%), Positives = 284/602 (47%), Gaps = 76/602 (12%)

Query: 493  QTIDICKHHANLCLNGRCIPTVSSYRC-ECNMGYKQDANGDCIDVDECTS-NPCTNGDCV 550
            + ID C+  ++ C +G+C     S++C  C  GY+    G C DV+EC   +PC+ G C 
Sbjct: 702  EDIDECRDPSS-CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCE 760

Query: 551  NTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTT 610
            N PGS+ C C  G+   P  ++C+D+DEC + G +C NG C NT GSFQC C +G+ L+ 
Sbjct: 761  NLPGSFRCTCAQGYAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSR 819

Query: 611  DGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDEC-QTPGICM 669
            D  +C D DEC     C+ G CIN +GS++C+C  G  L   GR C D+DEC Q P +C+
Sbjct: 820  DRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCL 878

Query: 670  -NGHCINSEGSFRCDCPPGLAVGMDGRVCVDT---HMRSTCYGGIKKGV-CVRPFPGAVT 724
             +G C N +GS+ C C  G     D   C +    H +  CY      V C       VT
Sbjct: 879  PHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVT 938

Query: 725  KSECCCANPDYGFGEPCQ--PCPAKNSAEFHGLCSSGVGITVDG----------RDINEC 772
            + ECCC+    G+G+ C+  PCP  +SAEFH LC  G G T D           RDI+EC
Sbjct: 939  QQECCCSL-GAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDEC 997

Query: 773  AL-DPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPG 831
             L   +IC  G C N +  Y C C  G+  D +   C+D+DECL +   C NG+C NT G
Sbjct: 998  MLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECL-DESNCRNGVCENTRG 1056

Query: 832  SYSCTCPPGYVFRTETETC-----EDINECESNP-CVNGACRNNLGSFNCECSPGSKLSS 885
             Y C C P   +      C      D++EC+    C  G C N  GS+ CEC P      
Sbjct: 1057 GYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGP 1116

Query: 886  TGLIC---------IDSLKGTCWLNI-QDSRCEVNINGATLK-SECCATLGAAWGSPCER 934
            +G  C             +  CW    +D  C   + G  L   +CC   G  WG+ C  
Sbjct: 1117 SGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRP 1176

Query: 935  CELDTA---CPRGLA-----------------RIKGVTCEDVNECEVFPGVCPNGRCVNS 974
            C    A   CP   +                 R +  + ED +EC      C +GRCV  
Sbjct: 1177 CPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPR 1231

Query: 975  KGSFHCECPEGLTLDGTGRVCLDI----RMEQCYLKWDEDECIHPVPGKFRMDACCCAVG 1030
             G   CECP G  LD +   C+DI     + Q  L    + C++   G FR   C C  G
Sbjct: 1232 PGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVN-TSGSFR---CVCKAG 1287

Query: 1031 AA 1032
             A
Sbjct: 1288 FA 1289



 Score =  340 bits (872), Expect = 1e-92
 Identities = 225/721 (31%), Positives = 309/721 (42%), Gaps = 129/721 (17%)

Query: 1782 PGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSY 1841
            PG  D+   C   PG+         VD++EC+  P     G+C+N  GS+ C C  G+  
Sbjct: 592  PGPPDYSCHCN--PGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRL 649

Query: 1842 NDLL--LVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG--ACVDRNECL 1897
            +       C D++EC+   +LC     CIN PG Y+C C  G++L  +    C D +EC 
Sbjct: 650  HVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR 708

Query: 1898 EIPNVCSHGLCVDLQGSYQCI-CHNGFKASQDQTMCMDVDEC-ERHPCGNGTCKNTVGSY 1955
            + P+ C  G C +  GS++CI C  G++ SQ    C DV+EC E  PC  G C+N  GS+
Sbjct: 709  D-PSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGSPCSPGWCENLPGSF 766

Query: 1956 NCLCYPGFE-LTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNC 2014
             C C  G+        CLD+DEC +  G VC NG C N  GSF+C C  GY L+ D  +C
Sbjct: 767  RCTCAQGYAPAPDGRSCLDVDECEA--GDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHC 824

Query: 2015 IDTNECVALPGSCSPGTCQNLEGSFRCICPPGYE-VKSENCIDINECDEDPNICL-FGSC 2072
             D +EC   P +C  G C N  GS+RC+CP G+  V    C DI+EC +DP++CL  G+C
Sbjct: 825  EDIDEC-DFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGAC 883

Query: 2073 TNTPGGFQCLCPPGFVLSDNGRRCFDTRQSF----CFTNFENGK-CSVPKAFNTTKAKCC 2127
             N  G + C+C  GF  + +   C +  Q      C+ NF++   C    A N T+ +CC
Sbjct: 884  KNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECC 943

Query: 2128 CSKMPGEGWGDPCEL--CPKDDEVAFQDLCPYGHGTVPSLH------DTREDVNEC-LES 2178
            CS   G GWGD CE+  CP      F  LCP G G     +          D++EC L  
Sbjct: 944  CSL--GAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFG 1001

Query: 2179 PGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGT----------- 2227
              IC  G+C+NT   + C C  G+  D   + CVD DEC   + C NG            
Sbjct: 1002 SEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCA 1061

Query: 2228 -----------------------------------CTNVIGSFECNCNEGFEPGPM-MNC 2251
                                               C N+ GS+ C C   + PGP   +C
Sbjct: 1062 CTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDC 1121

Query: 2252 EDINECAQNPLLCAFRCMNTFGSYE-CTCPI-GYALREDQKMCK---------------- 2293
            +     A+        C +  G    C  P+ G AL  D   C+                
Sbjct: 1122 QLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRG 1181

Query: 2294 ----------------------------DLDECAEGLHDCESRGMMCKNLIGTFMCICPP 2325
                                        D D   E   +C      C    G  +C CP 
Sbjct: 1182 AGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPG 1241

Query: 2326 GMARRPDGEGCVDENECRT---KPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNR 2382
            G         CVD +ECR    +  +C++ RCVN  GS+RC C  GF  S     C+  R
Sbjct: 1242 GFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQR 1301

Query: 2383 Q 2383
            +
Sbjct: 1302 R 1302



 Score =  337 bits (863), Expect = 1e-91
 Identities = 237/763 (31%), Positives = 327/763 (42%), Gaps = 155/763 (20%)

Query: 1800 DIHTGKAVDIDECKEIPGICAN-------------------------------------- 1821
            +I   +  + DEC+    IC +                                      
Sbjct: 566  EIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPC 625

Query: 1822 ----GVCINQIGSFRCECPTGFSYNDLL--LVCEDIDECSNGDNLCQRNADCINSPGSYR 1875
                G+C+N  GS+ C C  G+  +       C D++EC+   +LC     CIN PG Y+
Sbjct: 626  GPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYK 684

Query: 1876 CECAAGFKL--SPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCI-CHNGFKASQDQTMC 1932
            C C  G++L  S    C D +EC + P+ C  G C +  GS++CI C  G++ SQ    C
Sbjct: 685  CNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKPGSFKCIACQPGYR-SQGGGAC 742

Query: 1933 MDVDEC-ERHPCGNGTCKNTVGSYNCLCYPGF-ELTHNNDCLDIDECSSFFGQVCRNGRC 1990
             DV+EC E  PC  G C+N  GS+ C C  G+        CLD+DEC +  G VC NG C
Sbjct: 743  RDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA--GDVCDNGIC 800

Query: 1991 FNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYE-V 2049
             N  GSF+C C  GY L+ D  +C D +EC   P +C  G C N  GS+RC+CP G+  V
Sbjct: 801  SNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACIGGDCINTNGSYRCLCPQGHRLV 859

Query: 2050 KSENCIDINECDEDPNICL-FGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSF----C 2104
                C DI+EC +DP++CL  G+C N  G + C+C  GF  + +   C +  Q      C
Sbjct: 860  GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKEC 919

Query: 2105 FTNFENGK-CSVPKAFNTTKAKCCCSKMPGEGWGDPCEL--CPKDDEVAFQDLCPYGHGT 2161
            + NF++   C    A N T+ +CCCS   G GWGD CE+  CP      F  LCP G G 
Sbjct: 920  YLNFDDTVFCDSVLATNVTQQECCCSL--GAGWGDHCEIYPCPVYSSAEFHSLCPDGKGY 977

Query: 2162 VPSLH------DTREDVNEC-LESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDT 2214
                +          D++EC L    IC  G+C+NT   + C C  G+  D   + CVD 
Sbjct: 978  TQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDV 1037

Query: 2215 DECSIGNPCGNGTCTNVIGSFECNCNEGFEPGP-MMNC-----EDINECAQNPLLC-AFR 2267
            DEC   + C NG C N  G + C C    E  P    C      D++EC Q+P  C   R
Sbjct: 1038 DECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDEC-QDPAACRPGR 1096

Query: 2268 CMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHD----CESR----GMMCKNLIGTF 2319
            C+N  GSY C C   +      + C+  +  AE   +    C S+    GM    L G  
Sbjct: 1097 CVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPA 1156

Query: 2320 MCI-----------------CPP-------------------------GMARRPDGEGCV 2337
            +                   CPP                         G   R +     
Sbjct: 1157 LTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEE 1216

Query: 2338 DENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQM 2397
            D +ECR     C +GRCV   G   CEC  GFQ  +S   C+D  +           C+ 
Sbjct: 1217 DSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDE-----------CR- 1259

Query: 2398 ASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHG 2440
              + R L+ KSE C +    +   C+       A + +  PHG
Sbjct: 1260 ELNQRGLLCKSERCVNTSGSFRCVCK-------AGFARSRPHG 1295



 Score =  324 bits (831), Expect = 7e-88
 Identities = 231/748 (30%), Positives = 313/748 (41%), Gaps = 132/748 (17%)

Query: 496  DICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGD-CIDVDECTSNPCT--NGDCVNT 552
            D C+ + N+C +G C+P    Y C CN GY+       C+DV+EC + PC    G C+NT
Sbjct: 576  DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635

Query: 553  PGSYYCKCHAGFQRTPTK--QACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTT 610
             GSY C C+ G++       ++C+D++EC +  +    G C+N  G ++C C  G+ L  
Sbjct: 636  GGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKA 695

Query: 611  DGKN-CVDHDECTTTNMCLNGMCINEDGSFKCI-CKPGFVLAPNGRYCTDVDECQTPGIC 668
                 C D DEC   + C +G C N+ GSFKCI C+PG+  +  G  C DV+EC     C
Sbjct: 696  SRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGY-RSQGGGACRDVNECAEGSPC 754

Query: 669  MNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGG--IKKGVCVRPFPGAVTKS 726
              G C N  GSFRC C  G A   DGR C+D      C  G     G+C    PG+    
Sbjct: 755  SPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV---DECEAGDVCDNGICSNT-PGSF--- 807

Query: 727  ECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDG------------------RD 768
            +C C +  Y        C   +  +F   C  G  I  +G                  +D
Sbjct: 808  QCQCLS-GYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQD 866

Query: 769  INECALDPDICA-NGICENLRGSYRCNCNSGYEPDASGRNCIDID------ECLVN---R 818
            I+EC+ DP +C  +G C+NL+GSY C C+ G+ P      C +++      EC +N    
Sbjct: 867  IDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDT 926

Query: 819  LLCDNGLCRNTPGSYSCT--------------------------CPPGYVFRTETETCE- 851
            + CD+ L  N      C                           CP G  +  +      
Sbjct: 927  VFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNY 986

Query: 852  ------DINECE---SNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNI 902
                  DI+EC    S  C  G C N    + C C  G       L C+D     C   +
Sbjct: 987  GIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDV--DEC---L 1041

Query: 903  QDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVF 962
             +S C   +   T     CA    A  SP +R  L    P  +         DV+EC+  
Sbjct: 1042 DESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLS---PEEM---------DVDECQD- 1088

Query: 963  PGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVC---------LDIRMEQCYLKWDEDE-C 1012
            P  C  GRCVN  GS+ CEC        +GR C            R + C+ +  ED  C
Sbjct: 1089 PAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMC 1148

Query: 1013 IHPVPGK-FRMDACCCAVGAAWGTECEECPKPGTKEYETLCP----RGAGFANRGDVLTG 1067
              P+ G     D CCC  G  WG +C  CP  G   +   CP        F +   +L G
Sbjct: 1149 AGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH---CPTSQSESNSFWDTSPLLLG 1205

Query: 1068 RP------FYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRI 1121
            +P        +D +EC+     C  G+C    G   C C  GF LD     C DIDECR 
Sbjct: 1206 KPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE 1260

Query: 1122 SPD---LCGSGICVNTPGSFECECFEGY 1146
                  LC S  CVNT GSF C C  G+
Sbjct: 1261 LNQRGLLCKSERCVNTSGSFRCVCKAGF 1288



 Score =  307 bits (787), Expect = 9e-83
 Identities = 248/815 (30%), Positives = 341/815 (41%), Gaps = 173/815 (21%)

Query: 1930 TMCMDVDECE--RHPCGNGTCKNTVGSYNCLCYPGFEL-THNNDCLDIDECSSFFGQVCR 1986
            T   + DEC   ++ CG+G C      Y+C C PG+     +  C+D++EC +   + C 
Sbjct: 570  TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA---EPCG 626

Query: 1987 NGR--CFNEIGSFKCLCNEGYELT--PDGKNCIDTNECVALPGSCSPGT-CQNLEGSFRC 2041
             GR  C N  GS+ C CN GY L     G++C+D NEC A P  C  G  C N  G ++C
Sbjct: 627  PGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKC 685

Query: 2042 ICPPGYEVKSEN---CIDINECDEDPNICLFGSCTNTPGGFQCL-CPPGFVLSDNGRRCF 2097
             C PGY +K+     C DI+EC  DP+ C  G C N PG F+C+ C PG+  S  G  C 
Sbjct: 686  NCYPGYRLKASRPPVCEDIDEC-RDPSSCPDGKCENKPGSFKCIACQPGY-RSQGGGACR 743

Query: 2098 DTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPY 2157
            D  +       E   CS                    GW   CE  P     +F+  C  
Sbjct: 744  DVNECA-----EGSPCS-------------------PGW---CENLPG----SFRCTCAQ 772

Query: 2158 GHGTVPSLHDTRE--DVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTD 2215
            G+   P   D R   DV+EC E+  +C NG C NT GSF+C+C  GY+L      C D D
Sbjct: 773  GYAPAP---DGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDID 828

Query: 2216 ECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCA--FRCMNTFG 2273
            EC     C  G C N  GS+ C C +G        C+DI+EC+Q+P LC     C N  G
Sbjct: 829  ECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQG 888

Query: 2274 SYECTCPIGYALREDQKMCKDLD------ECAEGLHDCESRGMMCKNLIGTFM----CIC 2323
            SY C C  G+   +DQ  C++++      EC     D     + C +++ T +    C C
Sbjct: 889  SYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDT----VFCDSVLATNVTQQECCC 944

Query: 2324 PPGM--------------------ARRPDGEGCVDEN--------------ECRT-KPGI 2348
              G                     +  PDG+G   +N              EC      I
Sbjct: 945  SLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEI 1004

Query: 2349 CENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKS 2408
            C+ G+CVN    Y C C +GF    +  EC+D  +           C   S+ RN V   
Sbjct: 1005 CKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDE-----------CLDESNCRNGV--- 1050

Query: 2409 ECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINT 2468
               C+  RG G++C   P    +  ++ C      + +  D+DEC+  P  C  G+C+N 
Sbjct: 1051 ---CENTRG-GYRCACTPPAEYSPAQRQC-----LSPEEMDVDECQ-DPAACRPGRCVNL 1100

Query: 2469 MGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGK 2528
             GS+RC C+  +    SG  C    +  +SP       +  E    C   RG    EDG 
Sbjct: 1101 PGSYRCECRPPWVPGPSGRDC----QLPESPAE-----RAPERRDVCWSQRG----EDGM 1147

Query: 2529 TCKDLDECQTKQHNCQFLCVNTLG-GFTCK-CPPGFTQHH---TACIDNNECGSQPSLCG 2583
                L        +C   C    G G  C+ CPP     H   +    N+   + P L G
Sbjct: 1148 CAGPLAGPALTFDDC--CCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLG 1205

Query: 2584 ------------------AKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC-DGNHR- 2623
                                G C   PG   CEC  GF LDA+   C D+DEC + N R 
Sbjct: 1206 KPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRG 1265

Query: 2624 --CQ-HGCQNILGGYRCGCPQGYIQHYQWNQCVDE 2655
              C+   C N  G +RC C  G+ +      CV +
Sbjct: 1266 LLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQ 1300



 Score =  296 bits (757), Expect = 3e-79
 Identities = 228/764 (29%), Positives = 319/764 (41%), Gaps = 155/764 (20%)

Query: 943  RGLARIKGVTCEDVNECEVFPGVCPNGRCV------------------------------ 972
            R    I      + +EC +   +C +G CV                              
Sbjct: 562  RSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECE 621

Query: 973  ------------NSKGSFHCECPEG--LTLDGTGRVCLDI-RMEQCYLKWDEDECIHPVP 1017
                        N+ GS++C C  G  L +   GR C+D+    + +L  D   CI+  P
Sbjct: 622  AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCIN-FP 680

Query: 1018 GKFRMDACCCAVG----AAWGTECE---ECPKPGTKEYETLCPRGAGFANRGD--VLTGR 1068
            G ++   C C  G    A+    CE   EC  P +      CP G      G    +  +
Sbjct: 681  GHYK---CNCYPGYRLKASRPPVCEDIDECRDPSS------CPDGKCENKPGSFKCIACQ 731

Query: 1069 PFY--------KDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECR 1120
            P Y        +D+NEC A    C+ G C N  GSF+C C  G+A   + R+C D+DEC 
Sbjct: 732  PGYRSQGGGACRDVNEC-AEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECE 790

Query: 1121 ISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGS 1180
             + D+C +GIC NTPGSF+C+C  GY        +C DIDEC+  P  C GG C+NT GS
Sbjct: 791  -AGDVCDNGICSNTPGSFQCQCLSGYHLS-RDRSHCEDIDECD-FPAACIGGDCINTNGS 847

Query: 1181 FQCDCPLGHELSPSREDCVDINECSLSDNLC-RNGKCVNMIGTYQCSCNPGYQATPDRQG 1239
            ++C CP GH L   R+ C DI+ECS   +LC  +G C N+ G+Y C C+ G+  T D+ G
Sbjct: 848  YRCLCPQGHRLVGGRK-CQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHG 906

Query: 1240 CTDID------ECMIMNGG---CDTQCTNSEGSYECSCSEG------------------- 1271
            C +++      EC +       CD+    +    EC CS G                   
Sbjct: 907  CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE 966

Query: 1272 -YALMPDGRSCA--------------DIDECE-NNPDICDGGQCTNIPGEYRCLCYDGFM 1315
             ++L PDG+                 DIDEC     +IC  G+C N    Y C C  GF 
Sbjct: 967  FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFY 1026

Query: 1316 ASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGC-----TDVDE 1370
               ++  C+DV+EC L+ + C  G CENT+G + C C            C      DVDE
Sbjct: 1027 YDGNLLECVDVDEC-LDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDE 1085

Query: 1371 CEIGAHNCDMHASCLNIPGSFKCSCREGWI--GNGIKC-----------IDLDECSNGTH 1417
            C+  A        C+N+PGS++C CR  W+   +G  C              D C +   
Sbjct: 1086 CQDPA--ACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRG 1143

Query: 1418 QCSINAQCVNTPGSY--RCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCE 1475
            +  + A  +  P      C C +G  G G  C          + C   Q  +        
Sbjct: 1144 EDGMCAGPLAGPALTFDDCCCRQG-RGWGAQCRPCPPRGAGSH-CPTSQSESNSFWDTSP 1201

Query: 1476 CEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDE 1535
              +G  P  +  S +D DEC     CV G C   PG   C C  G++LD +   C DIDE
Sbjct: 1202 LLLGKPPRDEDSSEEDSDECR----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDE 1257

Query: 1536 CAD----PINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNR 1575
            C +     + C +  CVNT G + C C   F  +     CV  R
Sbjct: 1258 CRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQR 1301



 Score =  283 bits (725), Expect = 1e-75
 Identities = 229/801 (28%), Positives = 320/801 (39%), Gaps = 185/801 (23%)

Query: 1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGP--GT 1707
            + DEC+    +C  G C+     + C C  GY      R C D++EC A P  CGP  G 
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP--CGPGRGI 631

Query: 1708 CYNTLGNYTCICPPEY-MQVN-GGHNCMDMRKSFCYRSY---NGTTCENELPFNVTKRMC 1762
            C NT G+Y C C   Y + V  GG +C+D+ +  C + +   +G  C N  P +  K  C
Sbjct: 632  CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNE--CAKPHLCGDGGFCIN-FPGHY-KCNC 687

Query: 1763 CCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANG 1822
               Y +  +    CE                              DIDEC++ P  C +G
Sbjct: 688  YPGYRLKASRPPVCE------------------------------DIDECRD-PSSCPDG 716

Query: 1823 VCINQIGSFRC-ECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAG 1881
             C N+ GSF+C  C  G+  +     C D++EC+ G         C N PGS+RC CA G
Sbjct: 717  KCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGSPCSP--GWCENLPGSFRCTCAQG 773

Query: 1882 FKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECE- 1939
            +  +P+G +C+D +EC E  +VC +G+C +  GS+QC C +G+  S+D++ C D+DEC+ 
Sbjct: 774  YAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDF 832

Query: 1940 RHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKC 1999
               C  G C NT GSY CLC  G  L     C DIDECS        +G C N  GS+ C
Sbjct: 833  PAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC 892

Query: 2000 LCNEGYELTPDGKNC-----------------------------IDTNECVALPGSCSPG 2030
            +C+EG+  T D   C                             +   EC    G+    
Sbjct: 893  VCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGD 952

Query: 2031 TCQ------NLEGSFRCICPPGYEVKSENCI---------DINECD-EDPNICLFGSCTN 2074
             C+           F  +CP G     +N I         DI+EC      IC  G C N
Sbjct: 953  HCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVN 1012

Query: 2075 TPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGE 2134
            T  G++C C  GF    N   C D  +    +N  NG C      NT     C    P E
Sbjct: 1013 TQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCE-----NTRGGYRCACTPPAE 1067

Query: 2135 GWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSF 2194
                                  Y       L     DV+EC + P  C  G+C+N  GS+
Sbjct: 1068 ----------------------YSPAQRQCLSPEEMDVDEC-QDPAACRPGRCVNLPGSY 1104

Query: 2195 RCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGS---------------FECNC 2239
            RCEC   +    +G  C   +  +   P     C +  G                 +C C
Sbjct: 1105 RCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCC 1164

Query: 2240 NEG-----------------------------FEPGPMM-----NCEDINECAQNPLLC- 2264
             +G                             ++  P++       ED +E   +   C 
Sbjct: 1165 RQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCV 1224

Query: 2265 AFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCK-----NLIGTF 2319
            + RC+   G   C CP G+ L   +  C D+DEC E       RG++CK     N  G+F
Sbjct: 1225 SGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE----LNQRGLLCKSERCVNTSGSF 1280

Query: 2320 MCICPPGMAR-RPDGEGCVDE 2339
             C+C  G AR RP G  CV +
Sbjct: 1281 RCVCKAGFARSRPHG-ACVPQ 1300



 Score =  244 bits (623), Expect = 9e-64
 Identities = 191/582 (32%), Positives = 247/582 (42%), Gaps = 116/582 (19%)

Query: 2213 DTDECSIG-NPCGNGTCTNVIGSFECNCNEGFEPGPMMN-CEDINECAQNPLLCAFR--- 2267
            +TDEC +  N CG+G C      + C+CN G+   P    C D+NEC   P  C      
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP--CGPGRGI 631

Query: 2268 CMNTFGSYECTCPIGYALREDQ--KMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPP 2325
            CMNT GSY C C  GY L      + C DL+ECA+  H C   G  C N  G + C C P
Sbjct: 632  CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKP-HLCGDGGF-CINFPGHYKCNCYP 689

Query: 2326 GM---ARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRC-ECNEGFQSSSSGTECLDN 2381
            G    A RP    C D +ECR  P  C +G+C N  GS++C  C  G++S   G  C D 
Sbjct: 690  GYRLKASRPPV--CEDIDECRD-PSSCPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDV 745

Query: 2382 RQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGR---GWGHQCELCPLPGTAQYKKICP 2438
             +                           C +G     GW   CE   LPG+  ++  C 
Sbjct: 746  NE---------------------------CAEGSPCSPGW---CE--NLPGS--FRCTCA 771

Query: 2439 HGPGYTTDGR---DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDEC 2495
             G     DGR   D+DEC+   ++C NG C NT GSF+C C  GY      + C D+DEC
Sbjct: 772  QGYAPAPDGRSCLDVDECEA-GDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC 830

Query: 2496 SQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNC--QFLCVNTLGG 2553
                      C NT GSY+C CP+G+ L   G+ C+D+DEC      C     C N  G 
Sbjct: 831  DFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGS 889

Query: 2554 FTCKCPPGFT--------------QHHTACIDNNE----CGS-------QPSLCGAKGI- 2587
            + C C  GFT               H   C  N +    C S       Q   C + G  
Sbjct: 890  YVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG 949

Query: 2588 ----CQNTP------GSFSCECQ--RGFSLDATGLNC-----EDVDECD--GNHRCQHG- 2627
                C+  P        F   C   +G++ D   +N       D+DEC   G+  C+ G 
Sbjct: 950  WGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGK 1009

Query: 2628 CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFD 2687
            C N   GY C C QG+       +CVD +EC + + C +  C NT G Y+CAC     + 
Sbjct: 1010 CVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYS 1069

Query: 2688 QFSSAC-----HDVNECSSSKNPCNYG-CSNTEGGYLCGCPP 2723
                 C      DV+EC      C  G C N  G Y C C P
Sbjct: 1070 PAQRQCLSPEEMDVDECQDPA-ACRPGRCVNLPGSYRCECRP 1110



 Score =  242 bits (617), Expect = 4e-63
 Identities = 176/566 (31%), Positives = 226/566 (39%), Gaps = 103/566 (18%)

Query: 2253 DINECAQNPLLCAF-RCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMM 2311
            + +EC  N  +C    C+     Y C C  GY      + C D++EC      C     +
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA--EPCGPGRGI 631

Query: 2312 CKNLIGTFMCICPPGMARR--PDGEGCVDENECRTKPGIC-ENGRCVNIIGSYRCECNEG 2368
            C N  G++ C C  G        G  CVD NEC  KP +C + G C+N  G Y+C C  G
Sbjct: 632  CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPG 690

Query: 2369 FQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLP 2428
            ++  +S                   +C+     R+       C DG      +CE  P  
Sbjct: 691  YRLKASRPP----------------VCEDIDECRD----PSSCPDG------KCENKP-- 722

Query: 2429 GTAQYKKICPHGPGYTTDG----RDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDI 2484
                +K I    PGY + G    RD++EC    + C+ G C N  GSFRC C  GY    
Sbjct: 723  --GSFKCIACQ-PGYRSQGGGACRDVNEC-AEGSPCSPGWCENLPGSFRCTCAQGYAPAP 778

Query: 2485 SGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQ 2544
             G SC+D+DEC       N IC NT GS+QC C  GY L  D   C+D+DEC        
Sbjct: 779  DGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIG 838

Query: 2545 FLCVNTLGGFTCKCPPGFTQ-HHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGF 2603
              C+NT G + C CP G        C D +EC   PSLC   G C+N  GS+ C C  GF
Sbjct: 839  GDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898

Query: 2604 SLDATGLNCEDVDECDGNHRC-------------------QHGCQNILGG--------YR 2636
            +       CE+V++      C                   Q  C   LG         Y 
Sbjct: 899  TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP 958

Query: 2637 CG----------CP--QGYIQ-----HYQWNQCVDENECS--NPNACGSASCYNTLGSYK 2677
            C           CP  +GY Q     +Y      D +EC       C    C NT   Y+
Sbjct: 959  CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYE 1018

Query: 2678 CACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGC-PPGYYRVGQGHCVSG 2736
            C C  GF +D     C DV+EC    N  N  C NT GGY C C PP  Y   Q  C+S 
Sbjct: 1019 CYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLS- 1077

Query: 2737 MGFNKGQYLSLDTEVDEENALSPEAC 2762
                         E+D +    P AC
Sbjct: 1078 -----------PEEMDVDECQDPAAC 1092



 Score =  239 bits (609), Expect = 4e-62
 Identities = 203/746 (27%), Positives = 286/746 (38%), Gaps = 170/746 (22%)

Query: 768  DINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCR 827
            + +EC L+ +IC +G C      Y C+CN GY      R C+D++EC         G+C 
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633

Query: 828  NTPGSYSCTCPPGYVFRTET--ETCEDINEC-ESNPCVNGA-CRNNLGSFNCECSPGSKL 883
            NT GSY+C C  GY         +C D+NEC + + C +G  C N  G + C C PG +L
Sbjct: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRL 693

Query: 884  -SSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSEC-----------CATLG-AAWGS 930
             +S   +C D  +     +  D +CE N  G+     C           C  +   A GS
Sbjct: 694  KASRPPVCEDIDECRDPSSCPDGKCE-NKPGSFKCIACQPGYRSQGGGACRDVNECAEGS 752

Query: 931  PC--------------------------------ERCELDTACPRGLAR----------I 948
            PC                                + CE    C  G+            +
Sbjct: 753  PCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCL 812

Query: 949  KGV-------TCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRME 1001
             G         CED++EC+ FP  C  G C+N+ GS+ C CP+G  L G GR C DI  +
Sbjct: 813  SGYHLSRDRSHCEDIDECD-FPAACIGGDCINTNGSYRCLCPQGHRLVG-GRKCQDI--D 868

Query: 1002 QCYLKWDEDECI-----HPVPGKFRMDACCCAVGAAWGTE---CEECPKPGTK------- 1046
            +C    D   C+       + G +    C C  G     +   CEE  +P  K       
Sbjct: 869  EC--SQDPSLCLPHGACKNLQGSY---VCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNF 923

Query: 1047 ---------------EYETLCPRGAGFANRGDVLT------------------------- 1066
                           + E  C  GAG+ +  ++                           
Sbjct: 924  DDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNI 983

Query: 1067 ---GRPFYKDINECKAFPG-MCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRIS 1122
               G P ++DI+EC  F   +C  GKC NT   ++C C  GF  D     C D+DEC + 
Sbjct: 984  VNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LD 1042

Query: 1123 PDLCGSGICVNTPGSFECECFEGYESGFMMMKNC-----MDIDECERNPLLCRGGTCVNT 1177
               C +G+C NT G + C C    E      + C     MD+DEC+ +P  CR G CVN 
Sbjct: 1043 ESNCRNGVCENTRGGYRCACTPPAEYS-PAQRQCLSPEEMDVDECQ-DPAACRPGRCVNL 1100

Query: 1178 EGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDR 1237
             GS++C+C       PS  DC  + E        R   C +  G        G  A P  
Sbjct: 1101 PGSYRCECRPPWVPGPSGRDC-QLPESPAERAPERRDVCWSQRG------EDGMCAGPLA 1153

Query: 1238 QGCTDIDECMIMNG-------------GCDTQCTNSEGSYECSCSEGYALMPDGRSCADI 1284
                  D+C    G             G  + C  S+            L+  G+   D 
Sbjct: 1154 GPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLL--GKPPRDE 1211

Query: 1285 DECENNPDICD--GGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNEC-DLNSN--ICMFG 1339
            D  E + D C    G+C   PG   C C  GF        C+D++EC +LN    +C   
Sbjct: 1212 DSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSE 1271

Query: 1340 ECENTKGSFICHCQLGYSVKKGTTGC 1365
             C NT GSF C C+ G++  +    C
Sbjct: 1272 RCVNTSGSFRCVCKAGFARSRPHGAC 1297



 Score =  236 bits (602), Expect = 2e-61
 Identities = 174/591 (29%), Positives = 245/591 (41%), Gaps = 57/591 (9%)

Query: 2179 PGICSNGQCINTDGSF--RCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFE 2236
            PG+     C  + G+   + +C     L YTGV+                    V G   
Sbjct: 295  PGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGP----------------VRGEVG 338

Query: 2237 CNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMC-KDL 2295
             +C +G++     +C+DINECA   +     C+N  GSY C CP G++L   +  C  D 
Sbjct: 339  ADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398

Query: 2296 DECAEGLHDCESRGMMCKNLIGTFM----CICPPGMARRPDGEGCVDENECRTKPGICEN 2351
             E         S    C++ + T +    C C  G A     + C  +     K  IC  
Sbjct: 399  PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKE-ICPA 457

Query: 2352 GRCVNIIGSYRCECNEGFQSSSS--GTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSE 2409
            G+  +I+ S++    +G    S     +     Q L  +       +     R + T S 
Sbjct: 458  GKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSP 517

Query: 2410 CCCDGGRGWGHQC----------ELCPLPGTAQYKKICPHGPGYT-------TDGRDIDE 2452
               +      H            EL   P     +   P  P          T   + DE
Sbjct: 518  VSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDE 577

Query: 2453 CKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSP-KPCNYICKNTEG 2511
            C++  N+C +G+C+     + C C  GY +      C+D++EC   P  P   IC NT G
Sbjct: 578  CRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGG 637

Query: 2512 SYQCSCPRGYVLQ--EDGKTCKDLDECQTKQHNCQF--LCVNTLGGFTCKCPPGF---TQ 2564
            SY C C RGY L     G++C DL+EC  K H C     C+N  G + C C PG+     
Sbjct: 638  SYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 696

Query: 2565 HHTACIDNNECGSQPSLCGAKGICQNTPGSFSC-ECQRGFSLDATGLNCEDVDECDGNHR 2623
                C D +EC   PS C   G C+N PGSF C  CQ G+     G  C DV+EC     
Sbjct: 697  RPPVCEDIDEC-RDPSSC-PDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSP 753

Query: 2624 CQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPS 2682
            C  G C+N+ G +RC C QGY        C+D +EC   + C +  C NT GS++C C S
Sbjct: 754  CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLS 813

Query: 2683 GFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHC 2733
            G+   +  S C D++EC          C NT G Y C CP G+  VG   C
Sbjct: 814  GYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKC 864



 Score =  222 bits (565), Expect = 5e-57
 Identities = 215/783 (27%), Positives = 296/783 (37%), Gaps = 138/783 (17%)

Query: 181  ENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQ-VNNQMCQGQLTGIVCTKTLC 239
            +N C +G    GP   +C        C   YR+ P     V+   C+ +  G    + +C
Sbjct: 582  QNICGHGECVPGPPDYSC-------HCNPGYRSHPQHRYCVDVNECEAEPCGP--GRGIC 632

Query: 240  CATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTG--ACQDVDECQAIPGIC-QGGNCINTV 296
              T G    H           C RG+  ++  G  +C D++EC A P +C  GG CIN  
Sbjct: 633  MNTGGSYNCH-----------CNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFP 680

Query: 297  GSFECRCPAGHK-QSETTQKCEDIDECSIIPGICETGECSNTVGSYFCV-CPRGYVTSTD 354
            G ++C C  G++ ++     CEDIDEC   P  C  G+C N  GS+ C+ C  GY  S  
Sbjct: 681  GHYKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKPGSFKCIACQPGY-RSQG 738

Query: 355  GSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYR 414
            G  C D       S    G C + LPG     +C C  G  +       +C      E  
Sbjct: 739  GGACRDVNECAEGSPCSPGWC-ENLPG---SFRCTCAQG--YAPAPDGRSCLDVDECEAG 792

Query: 415  RLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGA 474
             +C +G+     PGS   +      +G+  S + +          P     G      G+
Sbjct: 793  DVCDNGI-CSNTPGSFQCQCL----SGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGS 847

Query: 475  GVGAGGQGPIITGLTILNQTIDICKHHANLCL-NGRCIPTVSSYRCECNMGYK--QDANG 531
                  QG  + G     Q ID C    +LCL +G C     SY C C+ G+   QD +G
Sbjct: 848  YRCLCPQGHRLVGGRKC-QDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHG 906

Query: 532  ------------------DCIDVDECTSNPCTNGDC------------------VNTPGS 555
                              D +  D   +   T  +C                  V +   
Sbjct: 907  CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE 966

Query: 556  YYCKCHAGFQRTPTKQ-------ACIDIDECIQNGV-LCKNGRCVNTDGSFQCICNAGFE 607
            ++  C  G   T           A  DIDEC+  G  +CK G+CVNT   ++C C  GF 
Sbjct: 967  FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFY 1026

Query: 608  LTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCT-----DVDEC 662
               +   CVD DEC   + C NG+C N  G ++C C P    +P  R C      DVDEC
Sbjct: 1027 YDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDEC 1086

Query: 663  QTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCV--------DTHMRSTCYGGI-KKG 713
            Q P  C  G C+N  GS+RC+C P    G  GR C             R  C+    + G
Sbjct: 1087 QDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDG 1146

Query: 714  VCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECA 773
            +C  P  G     + CC     G+G  C+PCP + +      C +    +    D +   
Sbjct: 1147 MCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH---CPTSQSESNSFWDTSPLL 1203

Query: 774  LDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSY 833
            L                       G  P     +  D DEC      C +G C   PG  
Sbjct: 1204 L-----------------------GKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGA 1235

Query: 834  SCTCPPGYVFRTETETCEDINEC-ESNP----CVNGACRNNLGSFNCECSPGSKLSSTGL 888
             C CP G+        C DI+EC E N     C +  C N  GSF C C  G   S    
Sbjct: 1236 VCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHG 1295

Query: 889  ICI 891
             C+
Sbjct: 1296 ACV 1298



 Score =  207 bits (528), Expect = 9e-53
 Identities = 221/875 (25%), Positives = 318/875 (36%), Gaps = 199/875 (22%)

Query: 26   TAGQPQPPPPKPPRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLR- 84
            T    +P P    RP PP  +           +  P+     +AV     +  + D  R 
Sbjct: 532  TTTPARPYPELISRPSPPTMR-----------WFLPDLPPSRSAVEIAPTQVTETDECRL 580

Query: 85   GPNVCGSR--------FHSYCCPGWKTLPGGNQCI-VPICR-NSCGDG--FCSRPN---M 129
              N+CG          +  +C PG+++ P    C+ V  C    CG G   C        
Sbjct: 581  NQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYN 640

Query: 130  CTCSSG-QISSTCGSKS---IQQCSVR--CMNGGTCADD----HCQCQKGYIGTYCGQPV 179
            C C+ G ++    G +S   + +C+    C +GG C +      C C  GY       PV
Sbjct: 641  CHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPV 700

Query: 180  CENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLC 239
            CE+  +    C  P+ C         +CE    +  C         QG   G  C     
Sbjct: 701  CEDIDE----CRDPSSCP------DGKCENKPGSFKCIACQPGYRSQG---GGACRDVNE 747

Query: 240  CATIGRAWGHPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGS 298
            CA         CE  P   +  C +G+ P     +C DVDEC+A   +C  G C NT GS
Sbjct: 748  CAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA-GDVCDNGICSNTPGS 806

Query: 299  FECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGY--------- 349
            F+C+C +G+  S     CEDIDEC   P  C  G+C NT GSY C+CP+G+         
Sbjct: 807  FQCQCLSGYHLSRDRSHCEDIDECD-FPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQ 865

Query: 350  ---VTSTDGSRCI---------DQRTGMCFSGLVNGR----------------------- 374
                 S D S C+              +C  G    +                       
Sbjct: 866  DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDD 925

Query: 375  ---CAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAG 431
               C   L   +T+ +CCC  G  WG       CPV  S E+  LC D            
Sbjct: 926  TVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPD------------ 973

Query: 432  SRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTIL 491
                   G G+    N   YG        IP                             
Sbjct: 974  -------GKGYTQDNNIVNYG--------IPA---------------------------- 990

Query: 492  NQTIDICK-HHANLCLNGRCIPTVSSYRCECNMGYKQDAN-GDCIDVDEC-TSNPCTNGD 548
            ++ ID C    + +C  G+C+ T   Y C C  G+  D N  +C+DVDEC   + C NG 
Sbjct: 991  HRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGV 1050

Query: 549  CVNTPGSYYCKCHAGFQRTPTKQACI-----DIDECIQNGVLCKNGRCVNTDGSFQCICN 603
            C NT G Y C C    + +P ++ C+     D+DEC Q+   C+ GRCVN  GS++C C 
Sbjct: 1051 CENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDEC-QDPAACRPGRCVNLPGSYRCECR 1109

Query: 604  AGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQ 663
              +     G++C   +           +C ++ G      + G    P        D+C 
Sbjct: 1110 PPWVPGPSGRDCQLPESPAERAPERRDVCWSQRG------EDGMCAGPLAGPALTFDDC- 1162

Query: 664  TPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRP----F 719
                C  G      G+    CPP  A    G  C  +   S  +      +  +P     
Sbjct: 1163 ---CCRQG---RGWGAQCRPCPPRGA----GSHCPTSQSESNSFWDTSPLLLGKPPRDED 1212

Query: 720  PGAVTKSECCCAN----PDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDG-RDINECAL 774
                   EC C +    P  G G  C+ CP      F    S    + +D  R++N+  L
Sbjct: 1213 SSEEDSDECRCVSGRCVPRPG-GAVCE-CP----GGFQLDASRARCVDIDECRELNQRGL 1266

Query: 775  DPDICANGICENLRGSYRCNCNSGYEPDASGRNCI 809
               +C +  C N  GS+RC C +G+        C+
Sbjct: 1267 ---LCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1298



 Score =  130 bits (328), Expect = 1e-29
 Identities = 60/167 (35%), Positives = 90/167 (53%), Gaps = 22/167 (13%)

Query: 913  GATLKSECCATLGAAWG-SPCERC----------------ELDTACPRGLARIKGVTCED 955
            G T + +CC ++G AWG S C +C                E+   CP+G  R+    C+D
Sbjct: 296  GLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQD 355

Query: 956  VNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQ---CY-LKWDEDE 1011
            +NEC + PGVC +G C+N+ GS+ C CP G +L  +   C+  + E+   C+ L   E +
Sbjct: 356  INECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQ 414

Query: 1012 CIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGF 1058
            C HP+  +     CCC+VG AWG  C+ CP  GT  ++ +CP G G+
Sbjct: 415  CQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGY 461



 Score = 97.4 bits (241), Expect = 2e-19
 Identities = 59/188 (31%), Positives = 87/188 (46%), Gaps = 38/188 (20%)

Query: 239 CCATIGRAWGHP-CEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVG 297
           CC +IG AWG   C  CP                             G+ + G     VG
Sbjct: 303 CCGSIGTAWGQSKCHKCPQLQYT------------------------GVQKPGPVRGEVG 338

Query: 298 SFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSR 357
           +    CP G+K+  +T  C+DI+EC++ PG+C  G+C N  GSY CVCP G+      ++
Sbjct: 339 A---DCPQGYKRLNSTH-CQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393

Query: 358 CI---DQRTGMCFSGLVN--GRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEE 412
           CI    +   +CF  LV+   +C   L  R+T+  CCC  G+ WG     + CP  G+  
Sbjct: 394 CIADKPEEKSLCFR-LVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARC--QRCPTDGTAA 450

Query: 413 YRRLCMDG 420
           ++ +C  G
Sbjct: 451 FKEICPAG 458



 Score = 95.5 bits (236), Expect = 7e-19
 Identities = 64/212 (30%), Positives = 84/212 (39%), Gaps = 42/212 (19%)

Query: 188  GRCI---GPNRCAC----VYGFTGPQCE--------RDYRTGPCFTQVNNQ-MCQGQLTG 231
            GRC+   G  RC C    V G +G  C+           R   C++Q     MC G L G
Sbjct: 1095 GRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAG 1154

Query: 232  IVCTKTLCCATIGRAWGHPCEMCPAQ------------------PQPCRRGFIPNIRTGA 273
               T   CC   GR WG  C  CP +                    P   G  P     +
Sbjct: 1155 PALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSS 1214

Query: 274  CQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPG---ICE 330
             +D DEC+     C  G C+   G   C CP G +   +  +C DIDEC  +     +C+
Sbjct: 1215 EEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCK 1269

Query: 331  TGECSNTVGSYFCVCPRGYVTSTDGSRCIDQR 362
            +  C NT GS+ CVC  G+  S     C+ QR
Sbjct: 1270 SERCVNTSGSFRCVCKAGFARSRPHGACVPQR 1301



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 44/138 (31%), Positives = 68/138 (49%), Gaps = 13/138 (9%)

Query: 652 NGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCV--DTHMRSTCYGG 709
           N  +C D++EC  PG+C +G C+N+ GS+RC CPPG ++G     C+      +S C+  
Sbjct: 349 NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRL 408

Query: 710 IK-KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVG------- 761
           +  +  C  P    +T+  CCC +    +G  CQ CP   +A F  +C +G G       
Sbjct: 409 VSPEHQCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSH 467

Query: 762 --ITVDGRDINECALDPD 777
             +T+ G       L PD
Sbjct: 468 QTLTIQGESDFSLFLHPD 485



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 48/160 (30%), Positives = 70/160 (43%), Gaps = 40/160 (25%)

Query: 2001 CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINEC 2060
            C +GY+   +  +C D NEC A+PG C  G C N  GS+RC+CPPG+ +       I + 
Sbjct: 341  CPQGYKRL-NSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398

Query: 2061 DEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFN 2120
             E+ ++C           F+ + P                           +C  P    
Sbjct: 399  PEEKSLC-----------FRLVSP-------------------------EHQCQHPLTTR 422

Query: 2121 TTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHG 2160
             T+  CCCS   G+ WG  C+ CP D   AF+++CP G G
Sbjct: 423  LTRQLCCCS--VGKAWGARCQRCPTDGTAAFKEICPAGKG 460



 Score = 75.9 bits (185), Expect = 6e-13
 Identities = 43/125 (34%), Positives = 58/125 (46%), Gaps = 12/125 (9%)

Query: 831 GSYSCTCPPGYVFRTETETCEDINECES-NPCVNGACRNNLGSFNCECSPGSKLSSTGLI 889
           G     CP GY  R  +  C+DINEC     C +G C NN GS+ C C PG  L  +   
Sbjct: 335 GEVGADCPQGYK-RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393

Query: 890 CI---DSLKGTCW-LNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELD------T 939
           CI      K  C+ L   + +C+  +     +  CC ++G AWG+ C+RC  D       
Sbjct: 394 CIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKE 453

Query: 940 ACPRG 944
            CP G
Sbjct: 454 ICPAG 458



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 61/237 (25%), Positives = 84/237 (35%), Gaps = 44/237 (18%)

Query: 495  IDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSN--PCTNGDCVNT 552
            +D C+  A  C  GRC+    SYRCEC   +    +G    + E  +   P     C + 
Sbjct: 1083 VDECQDPA-ACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQ 1141

Query: 553  PGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGR--------CVNTDGSFQCICNA 604
             G        G    P     +  D+C      C+ GR        C        C  + 
Sbjct: 1142 RGE------DGMCAGPLAGPALTFDDCC-----CRQGRGWGAQCRPCPPRGAGSHCPTSQ 1190

Query: 605  --------------GFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLA 650
                          G     +  +  D DEC     C++G C+   G   C C  GF L 
Sbjct: 1191 SESNSFWDTSPLLLGKPPRDEDSSEEDSDECR----CVSGRCVPRPGGAVCECPGGFQLD 1246

Query: 651  PNGRYCTDVDEC----QTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMR 703
             +   C D+DEC    Q   +C +  C+N+ GSFRC C  G A       CV    R
Sbjct: 1247 ASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR 1303



 Score = 66.2 bits (160), Expect = 4e-10
 Identities = 41/122 (33%), Positives = 60/122 (49%), Gaps = 12/122 (9%)

Query: 1087 GKC-RNTIGSFKCRCNSGFALDMEERNCTDI------DECRISPDLCGSGICVNTP--GS 1137
            G+C ++T+    C  N    L  +E  C  I       +C   P L  +G+    P  G 
Sbjct: 277  GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGE 336

Query: 1138 FECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSRED 1197
               +C +GY+   +   +C DI+EC   P +CR G C+N  GS++C CP GH L PSR  
Sbjct: 337  VGADCPQGYKR--LNSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393

Query: 1198 CV 1199
            C+
Sbjct: 394  CI 395



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 44/151 (29%), Positives = 65/151 (43%), Gaps = 25/151 (16%)

Query: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGH-QCELCPLPGTAQYKKICPHGP- 2441
            G CF + L      ++    L  + +CC   G  WG  +C  CP     QY  +   GP 
Sbjct: 277  GRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCP---QLQYTGVQKPGPV 333

Query: 2442 ----------GY----TTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGT 2487
                      GY    +T  +DI+EC  MP +C +G C+N  GS+RC C  G++   S T
Sbjct: 334  RGEVGADCPQGYKRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392

Query: 2488 SCIDLDECSQSPKPCNYICKNTEGSYQCSCP 2518
             CI     +  P+  +   +     +QC  P
Sbjct: 393  QCI-----ADKPEEKSLCFRLVSPEHQCQHP 418



 Score = 59.7 bits (143), Expect = 4e-08
 Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 25/129 (19%)

Query: 1774 KPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIP-----GICANGVCINQI 1828
            +PC   P PG    +  CG+I         G A    +C + P     G+   G    ++
Sbjct: 287  QPCGSNPLPGLTKQEDCCGSI---------GTAWGQSKCHKCPQLQYTGVQKPGPVRGEV 337

Query: 1829 GSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG 1888
            G+   +CP G+   +    C+DI+EC+    +C R+ DC+N+PGSYRC C  G  L P+ 
Sbjct: 338  GA---DCPQGYKRLNSTH-CQDINECAM-PGVC-RHGDCLNNPGSYRCVCPPGHSLGPS- 390

Query: 1889 ACVDRNECL 1897
                R +C+
Sbjct: 391  ----RTQCI 395



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 52/238 (21%), Positives = 84/238 (35%), Gaps = 46/238 (19%)

Query: 2631 ILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFS 2690
            + G     CPQGY +      C D NEC+ P  C    C N  GSY+C CP G S     
Sbjct: 333  VRGEVGADCPQGY-KRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391

Query: 2691 SAC-----HDVNEC---SSSKNPCNYGCSNTEGGYLC-------------GCPPGYYRVG 2729
            + C      + + C    S ++ C +  +      LC              CP       
Sbjct: 392  TQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAF 451

Query: 2730 QGHCVSGMGFN---KGQYLSLDTEVD------EENALSPEACYECKINGYSKKDSRQKRS 2780
            +  C +G G++     Q L++  E D       +    P+   E        +D+ ++R 
Sbjct: 452  KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERG 511

Query: 2781 IHEPDPTAVEQISLES---------------VDMDSPVNMKFNLSHLGSKEHILELRP 2823
            +    P + E+   +S               +   SP  M++ L  L      +E+ P
Sbjct: 512  VTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAP 569



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 24/64 (37%), Positives = 33/64 (51%), Gaps = 1/64 (1%)

Query: 512 PTVSSYRCECNMGYKQDANGDCIDVDECTS-NPCTNGDCVNTPGSYYCKCHAGFQRTPTK 570
           P       +C  GYK+  +  C D++EC     C +GDC+N PGSY C C  G    P++
Sbjct: 332 PVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391

Query: 571 QACI 574
             CI
Sbjct: 392 TQCI 395



 Score = 53.5 bits (127), Expect = 3e-06
 Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 5/80 (6%)

Query: 1868 INSPGSYRCE----CAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGF 1923
            +  PG  R E    C  G+K   +  C D NEC  +P VC HG C++  GSY+C+C  G 
Sbjct: 327  VQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA-MPGVCRHGDCLNNPGSYRCVCPPGH 385

Query: 1924 KASQDQTMCMDVDECERHPC 1943
                 +T C+     E+  C
Sbjct: 386  SLGPSRTQCIADKPEEKSLC 405



 Score = 53.1 bits (126), Expect = 4e-06
 Identities = 45/156 (28%), Positives = 66/156 (42%), Gaps = 28/156 (17%)

Query: 718 PFPGAVTKSECCCANPDYGFGEP-CQPCPAKNSAEFHGLCSSG-----VGI--------- 762
           P PG +TK E CC +    +G+  C  CP     ++ G+   G     VG          
Sbjct: 293 PLPG-LTKQEDCCGSIGTAWGQSKCHKCP---QLQYTGVQKPGPVRGEVGADCPQGYKRL 348

Query: 763 -TVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCI---DIDECLVNR 818
            +   +DINECA+ P +C +G C N  GSYRC C  G+    S   CI     ++ L  R
Sbjct: 349 NSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFR 407

Query: 819 LLCDNGLCRNTPGS----YSCTCPPGYVFRTETETC 850
           L+     C++   +      C C  G  +    + C
Sbjct: 408 LVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRC 443



 Score = 52.0 bits (123), Expect = 9e-06
 Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 2/63 (3%)

Query: 1953 GSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGK 2012
            G     C  G++  ++  C DI+EC+     VCR+G C N  GS++C+C  G+ L P   
Sbjct: 335  GEVGADCPQGYKRLNSTHCQDINECA--MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392

Query: 2013 NCI 2015
             CI
Sbjct: 393  QCI 395



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 34/90 (37%), Positives = 46/90 (51%), Gaps = 13/90 (14%)

Query: 175 CGQP-VCENG-CQNGGRCIGPNRCACVYGFT-GP---QC--ERDYRTGPCFTQVNNQ-MC 225
           C  P VC +G C N     G  RC C  G + GP   QC  ++      CF  V+ +  C
Sbjct: 359 CAMPGVCRHGDCLNNP---GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQC 415

Query: 226 QGQLTGIVCTKTLCCATIGRAWGHPCEMCP 255
           Q  LT  + T+ LCC ++G+AWG  C+ CP
Sbjct: 416 QHPLTTRL-TRQLCCCSVGKAWGARCQRCP 444



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 22/63 (34%), Positives = 33/63 (52%), Gaps = 2/63 (3%)

Query: 554 GSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGK 613
           G     C  G++R  +   C DI+EC   GV C++G C+N  GS++C+C  G  L     
Sbjct: 335 GEVGADCPQGYKRLNSTH-CQDINECAMPGV-CRHGDCLNNPGSYRCVCPPGHSLGPSRT 392

Query: 614 NCV 616
            C+
Sbjct: 393 QCI 395



 Score = 43.1 bits (100), Expect = 0.004
 Identities = 21/56 (37%), Positives = 29/56 (51%), Gaps = 2/56 (3%)

Query: 1911 LQGSYQCICHNGFKASQDQTMCMDVDECERHP-CGNGTCKNTVGSYNCLCYPGFEL 1965
            ++G     C  G+K   + T C D++EC     C +G C N  GSY C+C PG  L
Sbjct: 333  VRGEVGADCPQGYKRL-NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387



 Score = 40.0 bits (92), Expect = 0.034
 Identities = 45/164 (27%), Positives = 61/164 (37%), Gaps = 30/164 (18%)

Query: 53  GSEGGFLAPEYREEGAA---------------VASRVRR--RGQQDVLRGPNVCGSRFHS 95
           G+ GG LAPE R  GAA               +  RV     G++    G  +   RF  
Sbjct: 6   GAAGG-LAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARERFKV 64

Query: 96  YCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISS---TCGSKSIQQCSVR 152
              P    +     C+   CR+SC  G     NM        S+   T     +  C + 
Sbjct: 65  VFAP----VICKRTCLKGQCRDSCQQG----SNMTLIGENGHSTDTLTGSGFRVVVCPLP 116

Query: 153 CMNGGTCAD-DHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNR 195
           CMNGG C+  + C C   + G +C  P    G   GG   G +R
Sbjct: 117 CMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSR 160



 Score = 37.7 bits (86), Expect = 0.17
 Identities = 24/75 (32%), Positives = 30/75 (40%), Gaps = 19/75 (25%)

Query: 149 CSVRCMNGGTCADDHCQCQKGYIGTYCGQP---------------VCENGCQNGGRCIGP 193
           C   C+ G  C D    CQ+G   T  G+                VC   C NGG+C   
Sbjct: 71  CKRTCLKG-QCRDS---CQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSR 126

Query: 194 NRCACVYGFTGPQCE 208
           N+C C   FTG  C+
Sbjct: 127 NQCLCPPDFTGRFCQ 141


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score =  315 bits (807), Expect = 4e-85
 Identities = 364/1393 (26%), Positives = 535/1393 (38%), Gaps = 351/1393 (25%)

Query: 497  ICKHHANLCLNG-RCIP-TVSSYRCECNMGYKQDANGDCIDVDEC-TSNPCTNGDCVN-- 551
            +C      C NG  C+  ++    C+C  G+  +    C   D C  +  C NG      
Sbjct: 27   LCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGET---CQFPDPCQNAQLCQNGGSCQAL 83

Query: 552  --------------TPGSYYCKCHAGFQRTPTKQAC-IDIDECIQNGVLCKNGRC-VNTD 595
                          TP S+ C C  GF    T + C   +++        K GRC +   
Sbjct: 84   LPAPLGLPSSPSPLTP-SFLCTCLPGF----TGERCQAKLEDPCPPSFCSKRGRCHIQAS 138

Query: 596  GSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNG-MCINEDGSFKCICKPGFVLAPNGR 654
            G  QC C  G+     G+ C   D C+  N C+NG +C+      +C C PGF     G 
Sbjct: 139  GRPQCSCMPGWT----GEQCQLRDFCSA-NPCVNGGVCLATYPQIQCHCPPGF----EGH 189

Query: 655  YC-TDVDEC-QTPGICMNG-HCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIK 711
             C  DV+EC Q PG C  G  C N+ GSF+C CP    VG +G  C            ++
Sbjct: 190  ACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCP----VGQEGPRC-----------ELR 234

Query: 712  KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSG-VGITVDGRDIN 770
             G C  P  G        C+N     G  CQ  P K+S     LC  G +G         
Sbjct: 235  AGPC--PPRG--------CSN-----GGTCQLMPEKDSTFHLCLCPPGFIG--------P 271

Query: 771  ECALDPDICAN------GICENLRGSYRCNCNSGYEPDASGRNCI-DIDEC-LVNRLLCD 822
            +C ++PD C +      G C++   +Y C C   +    +G +C  D+DEC       C 
Sbjct: 272  DCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETW----TGWDCSEDVDECETQGPPHCR 327

Query: 823  N-GLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGA-CRNNLGSFNCECSPG 880
            N G C+N+ GS+ C C  G+     T   E++++C +  C  G+ C + +GSF+C C PG
Sbjct: 328  NGGTCQNSAGSFHCVCVSGW---GGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPG 384

Query: 881  SKLSSTGLICIDSLKGTCWLN--IQDSRCEVN-INGATLKSECCATLGAAWGSPCERCEL 937
                 TGL+C   L+  C       D++C  N + G+TL                     
Sbjct: 385  ----RTGLLC--HLEDMCLSQPCHGDAQCSTNPLTGSTL--------------------- 417

Query: 938  DTACPRGLARIKGVTC-EDVNEC---EVFPGVCPN-GRCVNSKGSFHCECPEGLTLDGTG 992
               C  G +   G TC +D++EC   +  P  C + G C+N+ GSF+C CP G     TG
Sbjct: 418  -CLCQPGYS---GPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGY----TG 469

Query: 993  RVCLDIRMEQCYLKWDEDECI----HPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEY 1048
              C          + D +EC+    HP                  G+ C +        +
Sbjct: 470  SRC----------EADHNECLSQPCHP------------------GSTCLDL----LATF 497

Query: 1049 ETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDM 1108
              LCP G         L G+    + NEC + P +  +  C + +  F+C C  GF+   
Sbjct: 498  HCLCPPG---------LEGQLCEVETNECASAPCL-NHADCHDLLNGFQCICLPGFSGTR 547

Query: 1109 EERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCM-DIDECERNPL 1167
             E    DIDECR SP     G C + PG+F C+C  G+E        C  ++DEC  +P 
Sbjct: 548  CEE---DIDECRSSP-CANGGQCQDQPGAFHCKCLPGFEG-----PRCQTEVDECLSDPC 598

Query: 1168 LCRGGTCVNTEGSFQCDCPLGH------------ELSPSREDCVDINECSLSDNLCRNGK 1215
               G +C++  G+F C CP G              L   ++ C D  +   ++ LC +G 
Sbjct: 599  PV-GASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKD--QKDKANCLCPDGS 655

Query: 1216 CVNMIGTYQCSCNPGYQATPDRQGCT-DI----DECMIMNGGCDT-------QCTNSEGS 1263
                     C+C+ G+     R  C  D+     EC    GGC +        C      
Sbjct: 656  PGCAPPEDNCTCHHGH---CQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSG 712

Query: 1264 YECSCSEGYALMPDGRSCA-DIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKT 1322
            Y C+C  GY     G +C+ ++  C + P + +GG C   PG Y C C            
Sbjct: 713  YNCTCPTGYT----GPTCSEEMTACHSGPCL-NGGSCNPSPGGYYCTCPPSHTGP----- 762

Query: 1323 CIDVNECDLNSNICMF------GECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAH 1376
                 +C  +++ C+       G C N  G+F C C +G+   +    C           
Sbjct: 763  -----QCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPR----CEGKLRPSCADS 813

Query: 1377 NCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCAC 1436
             C   A+C + P   +C C  G+ G   + + +D C+     C  N+ C+ T  S+ C C
Sbjct: 814  PCRNRATCQDSPQGPRCLCPTGYTGGSCQTL-MDLCAQ--KPCPRNSHCLQTGPSFHCLC 870

Query: 1437 SEGFTGD--GFTCSDVDECA-----ENINLCEN-GQCLNVPGAYRCECEMGFTPASDSRS 1488
             +G+TG       S   + A     +  +LC N G C++   +Y C C  GF        
Sbjct: 871  LQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGF----QGSL 926

Query: 1489 CQD-IDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCT-DIDECADPINCVNGL 1546
            CQD ++ C  +      TC   P  + C C  GY+    G NC+ ++D C       +G 
Sbjct: 927  CQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYD----GQNCSKELDACQSQPCHNHGT 982

Query: 1547 CVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSC 1606
            C   PG + C CPP F     G+ C +  V  C L       G+ +C++     ++ +  
Sbjct: 983  CTPKPGGFHCACPPGF----VGLRC-EGDVDEC-LDQPCHPTGTAACHS-----LANAFY 1031

Query: 1607 CCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNC 1666
            C  L    G  CE                              +ID C   P    GG C
Sbjct: 1032 CQCLPGHTGQWCEV-----------------------------EIDPCHSQP-CFHGGTC 1061

Query: 1667 INTFGS---FQCECPQGYYLSEDTRICEDIDEC----FAHPGVCGPG---------TCYN 1710
              T GS   F C CP+G+   E          C      H G+C P           C +
Sbjct: 1062 EATAGSPLGFICHCPKGF---EGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLS 1118

Query: 1711 TLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGK 1770
              G   C+ PP          C+          YNG +C            C C +    
Sbjct: 1119 GYGGPDCLTPPAPKGCGPPSPCL----------YNG-SCSETTGLGGPGFRCSCPH---- 1163

Query: 1771 AWNKPCEPCPTPG 1783
              + P   C  PG
Sbjct: 1164 --SSPGPRCQKPG 1174



 Score =  313 bits (802), Expect = 2e-84
 Identities = 330/1205 (27%), Positives = 464/1205 (38%), Gaps = 266/1205 (22%)

Query: 1081 PGMCTY-GKCR-NTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSF 1138
            P  C+  G+C     G  +C C  G+  +     C   D C  +P + G G+C+ T    
Sbjct: 124  PSFCSKRGRCHIQASGRPQCSCMPGWTGEQ----CQLRDFCSANPCVNG-GVCLATYPQI 178

Query: 1139 ECECFEGYESGFMMMKNCMDIDECERNPLLCRGGT-CVNTEGSFQCDCPLGHE------- 1190
            +C C  G+E          D++EC ++P  C  GT C NT GSFQC CP+G E       
Sbjct: 179  QCHCPPGFEGHACER----DVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELR 234

Query: 1191 ----------------LSPSRE---------------DCVDINECSLSDNLCRNG-KCVN 1218
                            L P ++               DC ++N  +   + C+NG  C +
Sbjct: 235  AGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDC-EVNPDNCVSHQCQNGGTCQD 293

Query: 1219 MIGTYQCSCNP---GYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALM 1275
             + TY C C     G+  + D   C         NGG    C NS GS+ C C  G+   
Sbjct: 294  GLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGT---CQNSAGSFHCVCVSGWG-- 348

Query: 1276 PDGRSCAD-IDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSN 1334
              G SC + +D+C        G  C +  G + CLC  G    +          C L  +
Sbjct: 349  --GTSCEENLDDCIA-ATCAPGSTCIDRVGSFSCLCPPGRTGLL----------CHLE-D 394

Query: 1335 ICMFGECENTK--------GSFICHCQLGYSVKKGTTGCTDVDEC---EIGAHNCDMHAS 1383
            +C+   C            GS +C CQ GYS   G T   D+DEC   + G   C+   S
Sbjct: 395  MCLSQPCHGDAQCSTNPLTGSTLCLCQPGYS---GPTCHQDLDECLMAQQGPSPCEHGGS 451

Query: 1384 CLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGD 1443
            CLN PGSF C C  G+ G+  +  D +EC +    C   + C++   ++ C C  G  G 
Sbjct: 452  CLNTPGSFNCLCPPGYTGSRCEA-DHNECLS--QPCHPGSTCLDLLATFHCLCPPGLEGQ 508

Query: 1444 GFTCSDVDECAENINLCENGQCLN------VPGAYRCECEMGFTPASDSRSCQDIDECSF 1497
                     C    N C +  CLN      +   ++C C  GF   S +R  +DIDEC  
Sbjct: 509  --------LCEVETNECASAPCLNHADCHDLLNGFQCICLPGF---SGTRCEEDIDECRS 557

Query: 1498 QNICVFGTCNNLPGMFHCICDDGYELDRTGGNC-TDIDECADPINCVNGLCVNTPGRYEC 1556
                  G C + PG FHC C  G+E    G  C T++DEC      V   C++ PG + C
Sbjct: 558  SPCANGGQCQDQPGAFHCKCLPGFE----GPRCQTEVDECLSDPCPVGASCLDLPGAFFC 613

Query: 1557 NCPPDFQ-------------LNPTGVGCVDNR-VGNCYLKFGPRGDGSLSCNTEIGVG-V 1601
             CP  F                P  + C D +   NC    G  G      N     G  
Sbjct: 614  LCPSGFTGQLCEVPLCAPNLCQPKQI-CKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHC 672

Query: 1602 SRSSCCCSLGKAWGNP-CE---------------TCPPVNSTEYYTLCPGGEGFRPNPIT 1645
             RSSC C +G  W  P CE               TC P   + Y   CP G      P  
Sbjct: 673  QRSSCVCDVG--WTGPECEAELGGCISAPCAHGGTCYP-QPSGYNCTCPTG---YTGP-- 724

Query: 1646 IILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGP 1705
               E++  C   P L  GG+C  + G + C CP  +      +     D C + P   G 
Sbjct: 725  TCSEEMTACHSGPCL-NGGSCNPSPGGYYCTCPPSH---TGPQCQTSTDYCVSAPCFNG- 779

Query: 1706 GTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRS--YNGTTCENE-------LPFN 1756
            GTC N  G ++C+C   +     G  C    +  C  S   N  TC++         P  
Sbjct: 780  GTCVNRPGTFSCLCAMGFQ----GPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTG 835

Query: 1757 VTKRMCCCTYNVGKAWNKPC---EPCPTPGTADFKTICGNIPGFT-----FDIHTGKAVD 1808
             T   C    ++     KPC     C   G + F  +C  + G+T       + + +   
Sbjct: 836  YTGGSCQTLMDL--CAQKPCPRNSHCLQTGPS-FHCLC--LQGWTGPLCNLPLSSCQKAA 890

Query: 1809 IDECKEIPGICAN-GVCINQIGSFRCECPTGFSYNDLLLVCED-IDECSNGDNLCQRNAD 1866
            + +  ++  +C N G+C++   S+ C CP GF  +    +C+D ++ C +    CQ  A 
Sbjct: 891  LSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGS----LCQDHVNPCES--RPCQNGAT 944

Query: 1867 CINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVC------SHGLCVDLQGSYQCICH 1920
            C+  P  Y C+CA G+         D   C +  + C      +HG C    G + C C 
Sbjct: 945  CMAQPSGYLCQCAPGY---------DGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACP 995

Query: 1921 NGFKASQDQTMCMDVDECERHPC---GNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDEC 1977
             GF   + +    DVDEC   PC   G   C +   ++ C C PG   T     ++ID C
Sbjct: 996  PGFVGLRCEG---DVDECLDQPCHPTGTAACHSLANAFYCQCLPGH--TGQWCEVEIDPC 1050

Query: 1978 SSFFGQVC-RNGRCFNEIGS---FKCLCNEGYE--------LTPDGKNCIDTNECVALPG 2025
             S   Q C   G C    GS   F C C +G+E         +    +C     C+  P 
Sbjct: 1051 HS---QPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPK 1107

Query: 2026 SCSPGTCQNLE--GSFRCICPPGYEVKSENCIDINECDEDPNICLF-GSCTNTPG----G 2078
               P  C  L   G   C+ PP      + C         P+ CL+ GSC+ T G    G
Sbjct: 1108 PGFPPRCACLSGYGGPDCLTPPA----PKGC-------GPPSPCLYNGSCSETTGLGGPG 1156

Query: 2079 FQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGW-G 2137
            F+C CP     S  G RC       C     +G C              CS  PG  W G
Sbjct: 1157 FRCSCPH----SSPGPRCQKPGAKGCEGRSGDGACDAG-----------CSG-PGGNWDG 1200

Query: 2138 DPCEL 2142
              C L
Sbjct: 1201 GDCSL 1205



 Score =  300 bits (769), Expect = 1e-80
 Identities = 336/1216 (27%), Positives = 476/1216 (39%), Gaps = 320/1216 (26%)

Query: 1696 CFAHPGVCGPG-TCYN-TLGNYTCICPPEYMQVNGGHNCMD----MRKSFCYRSYNGTTC 1749
            C + P  C  G TC + +LG  TC C P ++    G  C           C    NG +C
Sbjct: 28   CGSFPEPCANGGTCLSLSLGQGTCQCAPGFL----GETCQFPDPCQNAQLCQ---NGGSC 80

Query: 1750 ENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDI 1809
            +  LP  +                      P+P T  F  +C  +PGFT +    K  D 
Sbjct: 81   QALLPAPLG-----------------LPSSPSPLTPSF--LCTCLPGFTGERCQAKLED- 120

Query: 1810 DECKEIPGICAN-GVC-INQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADC 1867
              C   P  C+  G C I   G  +C C  G++       C+  D CS   N C     C
Sbjct: 121  -PCP--PSFCSKRGRCHIQASGRPQCSCMPGWTGEQ----CQLRDFCSA--NPCVNGGVC 171

Query: 1868 INSPGSYRCECAAGFKLSPNGACV-DRNECLEIPNVCSHGL-CVDLQGSYQCICHNGFKA 1925
            + +    +C C  GF+     AC  D NEC + P  C  G  C +  GS+QC+C  G   
Sbjct: 172  LATYPQIQCHCPPGFE---GHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG--- 225

Query: 1926 SQDQTMC-MDVDECERHPCGNG-TCK----NTVGSYNCLCYPGFELTHNNDC-LDIDECS 1978
             Q+   C +    C    C NG TC+         + CLC PGF      DC ++ D C 
Sbjct: 226  -QEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFI---GPDCEVNPDNCV 281

Query: 1979 SFFGQVCRNG-RCFNEIGSFKCLCNE---GYELTPDGKNCIDTNECVALPGSCSPGTCQN 2034
            S     C+NG  C + + ++ CLC E   G++ + D   C    E    P   + GTCQN
Sbjct: 282  S---HQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDEC----ETQGPPHCRNGGTCQN 334

Query: 2035 LEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCT------NTPGGFQCLCPPGFV 2088
              GSF C+C  G+   S        C+E+ + C+  +C       +  G F CLCPPG  
Sbjct: 335  SAGSFHCVCVSGWGGTS--------CEENLDDCIAATCAPGSTCIDRVGSFSCLCPPG-- 384

Query: 2089 LSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDE 2148
                G  C    +  C +   +G            A+C  + + G        LC     
Sbjct: 385  --RTGLLCH--LEDMCLSQPCHGD-----------AQCSTNPLTGS------TLC----- 418

Query: 2149 VAFQDLCPYGHGTVPSLHDTREDVNECL---ESPGICSNG-QCINTDGSFRCECPMGYNL 2204
                 LC  G+   P+ H   +D++ECL   + P  C +G  C+NT GSF C CP GY  
Sbjct: 419  -----LCQPGYSG-PTCH---QDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGY-- 467

Query: 2205 DYTGVRC-VDTDECSIGNPCGNG-TCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPL 2262
              TG RC  D +EC +  PC  G TC +++ +F C C  G E G +   E  NECA  P 
Sbjct: 468  --TGSRCEADHNEC-LSQPCHPGSTCLDLLATFHCLCPPGLE-GQLCEVET-NECASAPC 522

Query: 2263 LCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI 2322
            L    C +    ++C C  G++     +  +D+DEC      C + G  C++  G F C 
Sbjct: 523  LNHADCHDLLNGFQCICLPGFS---GTRCEEDIDECRSS--PCANGGQ-CQDQPGAFHCK 576

Query: 2323 CPPGMARRPDGEGCVDE-NECRTKPGICENGR-CVNIIGSYRCECNEGFQSSSSGTECLD 2380
            C PG     +G  C  E +EC + P  C  G  C+++ G++ C C  GF    +G  C  
Sbjct: 577  CLPGF----EGPRCQTEVDECLSDP--CPVGASCLDLPGAFFCLCPSGF----TGQLC-- 624

Query: 2381 NRQGLCFAEVLQT--ICQMASSSRNLVT----------------------KSECCCDGGR 2416
                LC   + Q   IC+      N +                       +S C CD G 
Sbjct: 625  -EVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVG- 682

Query: 2417 GW-GHQCEL---------CPLPGTAQ-----YKKICPHGPGYTTDGRDIDECKVMPNL-- 2459
             W G +CE          C   GT       Y   CP G    T   ++  C   P L  
Sbjct: 683  -WTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNG 741

Query: 2460 -----------CT------------------------NGQCINTMGSFRCFCKVGYT--- 2481
                       CT                         G C+N  G+F C C +G+    
Sbjct: 742  GSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPR 801

Query: 2482 --------------------------------TDISGTSCIDL-DECSQSPKPCNYICKN 2508
                                            T  +G SC  L D C+Q P P N  C  
Sbjct: 802  CEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQ 861

Query: 2509 TEGSYQCSCPRGYVLQEDGKTCK-DLDECQTKQ-----------HNCQFLCVNTLGGFTC 2556
            T  S+ C C +G+     G  C   L  CQ              HN   LCV++   + C
Sbjct: 862  TGPSFHCLCLQGWT----GPLCNLPLSSCQKAALSQGIDVSSLCHNGG-LCVDSGPSYFC 916

Query: 2557 KCPPGFTQHHTACIDN-NECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNC-ED 2614
             CPPGF    + C D+ N C S+P   GA   C   P  + C+C  G+     G NC ++
Sbjct: 917  HCPPGF--QGSLCQDHVNPCESRPCQNGAT--CMAQPSGYLCQCAPGYD----GQNCSKE 968

Query: 2615 VDECDGNHRCQHG-CQNILGGYRCGCPQGYIQ---HYQWNQCVDENECSNPNACGSASCY 2670
            +D C       HG C    GG+ C CP G++        ++C+D+  C   +  G+A+C+
Sbjct: 969  LDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQ-PC---HPTGTAACH 1024

Query: 2671 NTLGSYKCACPSGFSFDQFSSACH-DVNECSSSKNPCNYG--CSNTEG---GYLCGCPPG 2724
            +   ++ C C  G +       C  +++ C S   PC +G  C  T G   G++C CP G
Sbjct: 1025 SLANAFYCQCLPGHT----GQWCEVEIDPCHSQ--PCFHGGTCEATAGSPLGFICHCPKG 1078

Query: 2725 YYRVGQGHCVSGMGFN 2740
            +      H     GF+
Sbjct: 1079 FEGPTCSHRAPSCGFH 1094



 Score =  280 bits (717), Expect = 1e-74
 Identities = 355/1378 (25%), Positives = 500/1378 (36%), Gaps = 307/1378 (22%)

Query: 153  CMNGGTC-----ADDHCQCQKGYIGTYCGQP-VCENG--CQNGGRC-------------- 190
            C NGGTC         CQC  G++G  C  P  C+N   CQNGG C              
Sbjct: 35   CANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSP 94

Query: 191  --IGPN-RCACVYGFTGPQCERDY----------RTGPCFTQVNNQ---MCQGQLTGIVC 234
              + P+  C C+ GFTG +C+             + G C  Q + +    C    TG  C
Sbjct: 95   SPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQC 154

Query: 235  TKTLCCATIGRAWGHPCE---MCPAQPQPCRRGFIPNIRTGACQ-DVDECQAIPGIC-QG 289
                 C+       +PC    +C A     +    P     AC+ DV+EC   PG C +G
Sbjct: 155  QLRDFCSA------NPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKG 208

Query: 290  GNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSN----------TVG 339
             +C NT+GSF+C CP G          ++   C +  G C    CSN             
Sbjct: 209  TSCHNTLGSFQCLCPVG----------QEGPRCELRAGPCPPRGCSNGGTCQLMPEKDST 258

Query: 340  SYFCVCPRGYV---TSTDGSRCID---QRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
             + C+CP G++      +   C+    Q  G C  GL    C             C E  
Sbjct: 259  FHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTC------------LCPETW 306

Query: 394  RCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRP-------GGTGGNGFAPSG 446
              W      + C  +G       C +G   G    SAGS         GGT         
Sbjct: 307  TGWDCSEDVDECETQGPPH----CRNG---GTCQNSAGSFHCVCVSGWGGTSCEENLDDC 359

Query: 447  NGNGYGPGGTGFIPI--------PGGNGF----------SPGVGGAGVGAGGQGPIITGL 488
                  PG T    +        PG  G            P  G A          +TG 
Sbjct: 360  IAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNP----LTGS 415

Query: 489  TIL----NQTIDICKHHANLCL-----------NGRCIPTVSSYRCECNMGYKQDANGDC 533
            T+       +   C    + CL            G C+ T  S+ C C  GY       C
Sbjct: 416  TLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGY---TGSRC 472

Query: 534  -IDVDECTSNPCTNGD-CVNTPGSYYCKCHAGFQRTPTKQAC-IDIDECIQNGVLCKNGR 590
              D +EC S PC  G  C++   +++C C  G +     Q C ++ +EC     L  +  
Sbjct: 473  EADHNECLSQPCHPGSTCLDLLATFHCLCPPGLE----GQLCEVETNECASAPCL-NHAD 527

Query: 591  CVNTDGSFQCICNAGFELTTDGKNC-VDHDECTTTNMCLNGMCINEDGSFKCICKPGFVL 649
            C +    FQCIC  GF     G  C  D DEC ++     G C ++ G+F C C PGF  
Sbjct: 528  CHDLLNGFQCICLPGF----SGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGF-- 581

Query: 650  APNGRYC-TDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVC-VDTHMRSTCY 707
               G  C T+VDEC +    +   C++  G+F C CP G      G++C V     + C 
Sbjct: 582  --EGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFT----GQLCEVPLCAPNLCQ 635

Query: 708  GGIKKGVCVRPFPGAVTKSECCCANPDYGFGEP-CQPCPAKNSAEFHGLCSSGVGITVDG 766
                K +C         K+ C C  PD   G P C P P  N    HG C     +   G
Sbjct: 636  ---PKQIC----KDQKDKANCLC--PD---GSPGCAP-PEDNCTCHHGHCQRSSCVCDVG 682

Query: 767  RDINECALDPDICAN------GICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLL 820
                EC  +   C +      G C      Y C C +GY    +G  C +      +   
Sbjct: 683  WTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGY----TGPTCSEEMTACHSGPC 738

Query: 821  CDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVN-GACRNNLGSFNCECSP 879
             + G C  +PG Y CTCPP +   T  +     + C S PC N G C N  G+F+C C+ 
Sbjct: 739  LNGGSCNPSPGGYYCTCPPSH---TGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAM 795

Query: 880  GSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDT 939
            G +    G  C   L+ +C     DS C    N AT +        +  G  C       
Sbjct: 796  GFQ----GPRCEGKLRPSC----ADSPCR---NRATCQD-------SPQGPRC------- 830

Query: 940  ACPRGLARIKGVTCEDVNE-CEVFPGVCP-NGRCVNSKGSFHCECPEG-------LTLDG 990
             CP G     G +C+ + + C   P  CP N  C+ +  SFHC C +G       L L  
Sbjct: 831  LCPTGYT---GGSCQTLMDLCAQKP--CPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSS 885

Query: 991  TGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEE----CPKPGTK 1046
              +  L   ++   L  +   C+   P  F    C C  G   G+ C++    C     +
Sbjct: 886  CQKAALSQGIDVSSLCHNGGLCVDSGPSYF----CHCPPGFQ-GSLCQDHVNPCESRPCQ 940

Query: 1047 EYETLCPRGAGF-ANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFA 1105
               T   + +G+         G+   K+++ C++ P    +G C    G F C C  GF 
Sbjct: 941  NGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQP-CHNHGTCTPKPGGFHCACPPGF- 998

Query: 1106 LDMEERNCTDIDECRISP-DLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECER 1164
              +  R   D+DEC   P    G+  C +   +F C+C  G+   +      ++ID C  
Sbjct: 999  --VGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCE----VEIDPCHS 1052

Query: 1165 NPLLCRGGTCVNTEGS---FQCDCPLGHE--LSPSREDCVDINECSLSDNLCRNGKCVNM 1219
             P    GGTC  T GS   F C CP G E      R      + C     LC        
Sbjct: 1053 QPCF-HGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCH-HGGLCLPSPKPGF 1110

Query: 1220 IGTYQCSCNPGY-----QATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEG--- 1271
                +C+C  GY        P  +GC     C + NG C          + CSC      
Sbjct: 1111 --PPRCACLSGYGGPDCLTPPAPKGCGPPSPC-LYNGSCSETTGLGGPGFRCSCPHSSPG 1167

Query: 1272 -YALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDM----KTCIDV 1326
                 P  + C    E  +    CD G C+   G      +DG   S+ +    K C   
Sbjct: 1168 PRCQKPGAKGC----EGRSGDGACDAG-CSGPGGN-----WDGGDCSLGVPDPWKGCPSH 1217

Query: 1327 NECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASC 1384
            + C L     +F + +       CH Q             D +EC    ++C+   +C
Sbjct: 1218 SRCWL-----LFRDGQ-------CHPQ------------CDSEECLFDGYDCETPPAC 1251



 Score =  203 bits (516), Expect = 2e-51
 Identities = 256/973 (26%), Positives = 350/973 (35%), Gaps = 195/973 (20%)

Query: 128  NMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADD----HCQCQKGYIGTYCGQPV--CE 181
            ++C C  G I   C        S +C NGGTC D      C C + + G  C + V  CE
Sbjct: 260  HLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECE 319

Query: 182  NG----CQNGGRC---IGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVC 234
                  C+NGG C    G   C CV G+ G  CE +       T      C  ++    C
Sbjct: 320  TQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSC 379

Query: 235  TKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGAC--------------QDVDEC 280
               LC         H  +MC +QP         N  TG+               QD+DEC
Sbjct: 380  ---LCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDEC 436

Query: 281  ---QAIPGICQ-GGNCINTVGSFECRCPAGHKQSETTQKCE-DIDECSIIPGICETGE-C 334
               Q  P  C+ GG+C+NT GSF C CP G+    T  +CE D +EC   P  C  G  C
Sbjct: 437  LMAQQGPSPCEHGGSCLNTPGSFNCLCPPGY----TGSRCEADHNECLSQP--CHPGSTC 490

Query: 335  SNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSG--LVNGRCAQELPGRMTKMQCCCEP 392
             + + ++ C+CP G     +G  C +  T  C S   L +  C   L G     QC C P
Sbjct: 491  LDLLATFHCLCPPG----LEGQLC-EVETNECASAPCLNHADCHDLLNG----FQCICLP 541

Query: 393  GRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSR--PGGTGGNGFAPSGNG-N 449
            G     GT    C     E     C +G      PG+   +  PG  G           +
Sbjct: 542  GFS---GT---RCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLS 595

Query: 450  GYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHAN----LC 505
               P G   + +PG   F         G   + P+      L Q   ICK   +    LC
Sbjct: 596  DPCPVGASCLDLPG--AFFCLCPSGFTGQLCEVPLCA--PNLCQPKQICKDQKDKANCLC 651

Query: 506  LNGR--CIPTVSSYRCECNMGYKQDANGDC----------IDVDECTSNPCTN-GDCVNT 552
             +G   C P   +  C C+ G+ Q ++  C           ++  C S PC + G C   
Sbjct: 652  PDGSPGCAPPEDN--CTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQ 709

Query: 553  PGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDG 612
            P  Y C C  G+    T   C +      +G     G C  + G + C C      +  G
Sbjct: 710  PSGYNCTCPTGY----TGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPP----SHTG 761

Query: 613  KNCVDHDECTTTNMCLN-GMCINEDGSFKCICKPGFVLAPNGRYCTDV--DECQTPGICM 669
              C    +   +  C N G C+N  G+F C+C  GF     G  C       C       
Sbjct: 762  PQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGF----QGPRCEGKLRPSCADSPCRN 817

Query: 670  NGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECC 729
               C +S    RC CP G   G   +  +D   +  C    +   C++  P       C 
Sbjct: 818  RATCQDSPQGPRCLCPTGY-TGGSCQTLMDLCAQKPC---PRNSHCLQTGP----SFHCL 869

Query: 730  CANPDYGFGEP--------CQPCPAKNSAEFHGLCSSGVGITVDG--------------- 766
            C     G+  P        CQ        +   LC +G G+ VD                
Sbjct: 870  CLQ---GWTGPLCNLPLSSCQKAALSQGIDVSSLCHNG-GLCVDSGPSYFCHCPPGFQGS 925

Query: 767  ---RDINECALDPDICANG-ICENLRGSYRCNCNSGYEPDASGRNCI-DIDECLVNRLLC 821
                 +N C   P  C NG  C      Y C C  GY+    G+NC  ++D C  ++   
Sbjct: 926  LCQDHVNPCESRP--CQNGATCMAQPSGYLCQCAPGYD----GQNCSKELDAC-QSQPCH 978

Query: 822  DNGLCRNTPGSYSCTCPPGYVFRTETETCE-DINECESNPC---VNGACRNNLGSFNCEC 877
            ++G C   PG + C CPPG+V       CE D++EC   PC      AC +   +F C+C
Sbjct: 979  NHGTCTPKPGGFHCACPPGFV----GLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQC 1034

Query: 878  SPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCEL 937
             PG     TG          C + I     +   +G T    C AT G+  G  C     
Sbjct: 1035 LPG----HTG--------QWCEVEIDPCHSQPCFHGGT----CEATAGSPLGFICH---- 1074

Query: 938  DTACPRGLARIKGVTCE------DVNEC--------EVFPGVCPNGRCVNSKGSFHCECP 983
               CP+G    +G TC         + C           PG  P   C++  G   C  P
Sbjct: 1075 ---CPKG---FEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTP 1128

Query: 984  EGLTLDGTGRVCL 996
                  G    CL
Sbjct: 1129 PAPKGCGPPSPCL 1141



 Score =  166 bits (420), Expect = 3e-40
 Identities = 220/891 (24%), Positives = 309/891 (34%), Gaps = 215/891 (24%)

Query: 87   NVCGSRFHSYCCPGW---KTLPGGNQCIVPICR--NSCGDGFCSRPNMCTCSSGQISSTC 141
            N  GS F+  C PG+   +     N+C+   C   ++C D   +    C C  G     C
Sbjct: 454  NTPGS-FNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFH--CLCPPGLEGQLC 510

Query: 142  GSKSIQQCSVRCMNGGTCAD----DHCQCQKGYIGTYCGQPVCE---NGCQNGGRCI--- 191
              ++ +  S  C+N   C D      C C  G+ GT C + + E   + C NGG+C    
Sbjct: 511  EVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQP 570

Query: 192  GPNRCACVYGFTGPQCERDYR---TGPCFTQVNNQ--------MCQGQLTGIVCTKTLCC 240
            G   C C+ GF GP+C+ +     + PC    +          +C    TG +C   LC 
Sbjct: 571  GAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCA 630

Query: 241  ATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFE 300
              + +    P ++C  Q         P+   G     D C    G CQ  +C+  VG   
Sbjct: 631  PNLCQ----PKQICKDQKDKANC-LCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTG 685

Query: 301  CRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCID 360
              C A            ++  C   P     G C      Y C CP GY     G  C +
Sbjct: 686  PECEA------------ELGGCISAP-CAHGGTCYPQPSGYNCTCPTGYT----GPTCSE 728

Query: 361  QRTGMCFSG-LVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMD 419
            + T  C SG  +NG      PG      C C P       T P+    + S +Y   C+ 
Sbjct: 729  EMTA-CHSGPCLNGGSCNPSPG---GYYCTCPPSH-----TGPQC---QTSTDY---CV- 772

Query: 420  GLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAG 479
                     SA    GGT  N                            PG        G
Sbjct: 773  ---------SAPCFNGGTCVN---------------------------RPGTFSCLCAMG 796

Query: 480  GQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCID-VDE 538
             QGP   G    +     C++ A       C  +    RC C  GY     G C   +D 
Sbjct: 797  FQGPRCEGKLRPSCADSPCRNRAT------CQDSPQGPRCLCPTGY---TGGSCQTLMDL 847

Query: 539  CTSNPC-TNGDCVNTPGSYYCKCHAGF------------QRTPTKQACIDIDECIQNGVL 585
            C   PC  N  C+ T  S++C C  G+            Q+    Q  ID+     NG  
Sbjct: 848  CAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQG-IDVSSLCHNG-- 904

Query: 586  CKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNG-MCINEDGSFKCICK 644
               G CV++  S+ C C  GF+    G  C DH     +  C NG  C+ +   + C C 
Sbjct: 905  ---GLCVDSGPSYFCHCPPGFQ----GSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCA 957

Query: 645  PGFVLAPNGRYCT-DVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMR 703
            PG+    +G+ C+ ++D CQ+     +G C    G F C CPPG  VG+           
Sbjct: 958  PGY----DGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGF-VGL----------- 1001

Query: 704  STCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGIT 763
              C G +                EC             QPC    +A  H L ++     
Sbjct: 1002 -RCEGDV---------------DECL-----------DQPCHPTGTAACHSLANAFYCQC 1034

Query: 764  VDGRDINECALDPDICAN------GICENLRGS---YRCNCNSGYEPDASGRNCIDIDEC 814
            + G     C ++ D C +      G CE   GS   + C+C  G+E    G  C      
Sbjct: 1035 LPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFE----GPTCSHRAPS 1090

Query: 815  LVNRLLCDNGLCRNTPG---SYSCTCPPGYVFRTETETCEDINEC-ESNPCV-NGACRNN 869
                     GLC  +P       C C  GY    +  T      C   +PC+ NG+C   
Sbjct: 1091 CGFHHCHHGGLCLPSPKPGFPPRCACLSGY-GGPDCLTPPAPKGCGPPSPCLYNGSCSET 1149

Query: 870  LG----SFNCEC---SPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNING 913
             G     F C C   SPG +    G    +   G       D  C+   +G
Sbjct: 1150 TGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSG-------DGACDAGCSG 1193



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 102/393 (25%), Positives = 133/393 (33%), Gaps = 100/393 (25%)

Query: 90   GSRFHSYCCPGWKTLPGGNQCIVPI--CRNSC------------GDGFC--SRPN-MCTC 132
            G  FH  C  GW     G  C +P+  C+ +               G C  S P+  C C
Sbjct: 863  GPSFHCLCLQGWT----GPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHC 918

Query: 133  SSGQISSTCGSKSIQQCSVR-CMNGGTCADDH----CQCQKGYIGTYCGQPV--CENG-C 184
              G   S C    +  C  R C NG TC        CQC  GY G  C + +  C++  C
Sbjct: 919  PPGFQGSLC-QDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPC 977

Query: 185  QNGGRCI---GPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCA 241
             N G C    G   CAC  GF G +CE D        +  +Q C         T T  C 
Sbjct: 978  HNHGTCTPKPGGFHCACPPGFVGLRCEGD------VDECLDQPCHP-------TGTAACH 1024

Query: 242  TIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQ-DVDECQAIPGICQGGNCINTVGS-- 298
            ++  A+   C              +P      C+ ++D C + P    GG C  T GS  
Sbjct: 1025 SLANAFYCQC--------------LPGHTGQWCEVEIDPCHSQP-CFHGGTCEATAGSPL 1069

Query: 299  -FECRCPAGHKQSETTQK--------CEDIDEC--SIIPGICETGECSNTVGSYFCVCPR 347
             F C CP G +    + +        C     C  S  PG      C +  G   C+ P 
Sbjct: 1070 GFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPP 1129

Query: 348  GYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCC---EPG-RCWGIGTIPE 403
                    S C           L NG C++         +C C    PG RC   G   +
Sbjct: 1130 APKGCGPPSPC-----------LYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGA--K 1176

Query: 404  ACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGG 436
             C  R          DG    G  G  G+  GG
Sbjct: 1177 GCEGRSG--------DGACDAGCSGPGGNWDGG 1201



 Score = 45.8 bits (107), Expect = 6e-04
 Identities = 46/184 (25%), Positives = 64/184 (34%), Gaps = 46/184 (25%)

Query: 85   GPNVCGSRFHSYCCPGWKTLPG--GNQCIVPI-------------CRNSCGD--GFCSRP 127
            G   C S  +++ C   + LPG  G  C V I             C  + G   GF    
Sbjct: 1019 GTAACHSLANAFYC---QCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGF---- 1071

Query: 128  NMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADD-------HCQCQKGYIGTYCGQPVC 180
             +C C  G    TC  ++       C +GG C           C C  GY G  C  P  
Sbjct: 1072 -ICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPA 1130

Query: 181  ENGCQNGGRCI------------GPN-RCACVYGFTGPQCERDYRTGPCFTQVNNQMCQG 227
              GC     C+            GP  RC+C +   GP+C++    G C  +  +  C  
Sbjct: 1131 PKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKG-CEGRSGDGACDA 1189

Query: 228  QLTG 231
              +G
Sbjct: 1190 GCSG 1193


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  304 bits (779), Expect = 7e-82
 Identities = 374/1457 (25%), Positives = 538/1457 (36%), Gaps = 272/1457 (18%)

Query: 1073 DINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICV 1132
            D++EC+   G C + +C NT GS+ C C  GF L  + R C  I+ C +    C      
Sbjct: 161  DVDECRTHNGGCQH-RCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQ 219

Query: 1133 NTPGSFECECFEGY---ESGFMMMKNCMDIDECERNPLLCRGGTCVN----TEGSFQCDC 1185
             T     C+C  G+   E G    ++C+      R+P   R G+C++      G  +C+C
Sbjct: 220  LTITRHRCQCRPGFQLQEDG----RHCV-----RRSPCANRNGSCMHRCQVVRGLARCEC 270

Query: 1186 PLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDID- 1244
             +G++L+   + C D++EC+     C +G C+N  G+++C C+ GY+   D + C  I+ 
Sbjct: 271  HVGYQLAADGKACEDVDECAAGLAQCAHG-CLNTQGSFKCVCHAGYELGADGRQCYRIEM 329

Query: 1245 ----ECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCT 1300
                 C   NGGC   C+++     C+C  GY L  D R+C D+D+C ++P  C    CT
Sbjct: 330  EIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSP--CCQQVCT 387

Query: 1301 NIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKK 1360
            N PG Y C CY G+  S D   C DV+EC  +   C    C N  GSF C C+ GY + +
Sbjct: 388  NNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEH-HCTNLAGSFQCSCEAGYRLHE 446

Query: 1361 GTTGCTDVDE------CEIGAHNCDMHASCL--NIPGSF----------KCSCR-EGWIG 1401
               GC+ ++E       E+       H + L   +P  F          +   R E  + 
Sbjct: 447  DRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLT 506

Query: 1402 NGIKCIDLD---ECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDV---DECAE 1455
                C+D     +CS     C     C+   G   C C EG+T  G  C++    D   +
Sbjct: 507  EKFVCLDDSFGHDCSLTCDDCRNGGTCL--LGLDGCDCPEGWT--GLICNETCPPDTFGK 562

Query: 1456 NINL---CEN-GQCLNVPGAYRC-------ECEMGFTPASDSRSCQDIDECSFQNIC--V 1502
            N +    C+N G C +V GA RC        CE G       + C+    C+ +  C  +
Sbjct: 563  NCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRL 622

Query: 1503 FGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADP----INCVNGLCVNTPGRYECNC 1558
            +G C   PG++   C         G  C++  +C  P     +  +G C    G     C
Sbjct: 623  YGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERC 682

Query: 1559 PPDFQLNPTGVGC-----------VDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSC- 1606
              + +L   G GC            D+  G C  K  P G     C  E  VG    +C 
Sbjct: 683  QAECELGYFGPGCWQACTCPVGVACDSVSGECG-KRCPAGFQGEDCGQECPVGTFGVNCS 741

Query: 1607 -CCSLGKAWGNPCE------TCPPVNSTEYYTL-CPGGE-GFRPNPITIILEDIDECQEL 1657
              CS G   G PC        CPP  + E     CP G  G     I    +    C   
Sbjct: 742  SSCSCG---GAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPE 798

Query: 1658 PGLCQGGNCINTFGSFQCE--CPQGYYLSEDTRICEDIDECFAHPGV----CGPG----T 1707
             G C    C+  F   +C+  CP G+Y       C   ++   HP      C PG    +
Sbjct: 799  TGACL---CLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFS 855

Query: 1708 CYNT--LGNYTCICPPEYMQVNGGHNCMDMRKSFCY--RSYNGTTCENELPFN----VTK 1759
            C      G++   C       + GH   D     C     Y G  CE + P        +
Sbjct: 856  CQRACDTGHWGPDC-SHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCE 914

Query: 1760 RMCCCTYNVGKAWNKPCEPCPTPGTADFK-TICGN-IPGFTFDIHTGKAVDIDECKEIPG 1817
            + C C +  G A +     C  P  A ++ T C +  P   F +         +C+    
Sbjct: 915  QRCQCQH--GAACDHVSGACTCP--AGWRGTFCEHACPAGFFGL---------DCRSACN 961

Query: 1818 ICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCIN----SPGS 1873
              A   C    GS  C CP G         C +        + C +   C N     P  
Sbjct: 962  CTAGAACDAVNGS--CLCPAGRRGPR----CAETCPAHTYGHNCSQACACFNGASCDPVH 1015

Query: 1874 YRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCM 1933
             +C CA G+ + P+        CL+    C  GL  D    + C+C NG           
Sbjct: 1016 GQCHCAPGW-MGPS--------CLQ---ACPAGLYGD-NCRHSCLCQNG----------- 1051

Query: 1934 DVDECERHPCGNGTCKNTVGSYNCLCYPGFE-LTHNNDCL--DIDECSSFFGQVCRNGRC 1990
                        GTC    G  +C C  G+  L    +CL  D+       G     G C
Sbjct: 1052 ------------GTCDPVSG--HCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLC 1097

Query: 1991 FNEIGSFKCLCNEGYELTPDGKNCID--TNECVALPGSCSPG-TCQNLEGSFRC------ 2041
                G  +CLC  G+        C+     E  A   SC PG  C ++ G+ RC      
Sbjct: 1098 DPHTG--RCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTG 1155

Query: 2042 -----ICPPGYEVKSENCIDINECDEDPNIC--LFGSCTNTPG----GFQCLCPPGFVLS 2090
                  CPPG     E+C  + +C  +   C    G+C+   G      Q  CPPG    
Sbjct: 1156 SGCEQACPPG--SFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGP 1213

Query: 2091 DNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCC---------CSKMPGEGWGDPCE 2141
               + C       C  +   G C  P  F  T              C+ + G G G  C 
Sbjct: 1214 GCEQLCGCLNGGSC--DAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAAC- 1270

Query: 2142 LCPKDDEVAFQDLCPYGHGTV---PSLHDTREDVNECLESPGICSNGQCINTDGSFRCEC 2198
                 D V    LCP G   V         R  V  C  +    + G C  ++GS  C C
Sbjct: 1271 -----DPVTGTCLCPPGRAGVRCERGCPQNRFGVG-CEHTCSCRNGGLCHASNGS--CSC 1322

Query: 2199 PMGYNLDYTGVRCVDTD-------ECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNC 2251
             +G+   +  + C           ECS  N   N TC    G+  C C  GF       C
Sbjct: 1323 GLGWTGRHCELACPPGRYGAACHLECSCHN---NSTCEPATGT--CRCGPGFYG---QAC 1374

Query: 2252 EDINECAQNPLLCAFRCMNTFG------SYECTCPIGYALREDQKMCKDLDECAEGLH-- 2303
            E       +   C   C    G      S  C CP G+     ++ C+      EG H  
Sbjct: 1375 EHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEP-GSFGEGCHQR 1433

Query: 2304 -DCESRGMMCKNLIGTFMCICPPGMA---------RRPDGEGCVDENECRTKPGICE--N 2351
             DC+  G  C  + G  +C+CPPG +         R   G  C    +C      C+  +
Sbjct: 1434 CDCDG-GAPCDPVTG--LCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGAD-CDPVS 1489

Query: 2352 GRCVNIIGSYRCECNEG 2368
            G+C  + G     C EG
Sbjct: 1490 GQCHCVDGYMGPTCREG 1506



 Score =  295 bits (754), Expect = 6e-79
 Identities = 415/1640 (25%), Positives = 565/1640 (34%), Gaps = 378/1640 (23%)

Query: 1099 RCNSGFALDMEERNCTDIDECRISPDLC-GSGICVNTPGSFE-CECFEGYESGFMMMKNC 1156
            RC  G+    +E  C    EC  S  LC   G CV  PGS + C C  G++        C
Sbjct: 109  RCCRGWMQQPDEEGCLSA-EC--SASLCFHGGRCV--PGSAQPCHCPPGFQG-----PRC 158

Query: 1157 M-DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGK 1215
              D+DEC  +   C+   CVNT GS+ C+C  G  L      C+ IN C+L +  C++  
Sbjct: 159  QYDVDECRTHNGGCQH-RCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQH-H 216

Query: 1216 CVNM-IGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYAL 1274
            CV + I  ++C C PG+Q   D + C     C   NG C  +C    G   C C  GY L
Sbjct: 217  CVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQL 276

Query: 1275 MPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCID-----VNEC 1329
              DG++C D+DEC      C  G C N  G ++C+C+ G+    D + C       VN C
Sbjct: 277  AADGKACEDVDECAAGLAQCAHG-CLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSC 335

Query: 1330 DLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPG 1389
            + N+  C  G C +T    +C C  GY +      C DVD+C   A +      C N PG
Sbjct: 336  EANNGGCSHG-CSHTSAGPLCTCPRGYELDTDQRTCIDVDDC---ADSPCCQQVCTNNPG 391

Query: 1390 SFKCSCREGW--IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT--GDGF 1445
             ++C C  G+    +G  C D+DEC++    C     C N  GS++C+C  G+    D  
Sbjct: 392  GYECGCYAGYRLSADGCGCEDVDECASSRGGC--EHHCTNLAGSFQCSCEAGYRLHEDRR 449

Query: 1446 TCSDVDECAENIN------------------LCENGQCLNVPGAYRCECEM-GFTPASDS 1486
             CS ++E   +++                  L +  Q  +V GA   E E+ G    ++ 
Sbjct: 450  GCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDV-GADEEEAELRGEHTLTEK 508

Query: 1487 RSCQD----------IDECSFQNICVFGT--CNNLPGMFHCICDDGYELDRTGGNCTDID 1534
              C D           D+C     C+ G   C+   G    IC++    D  G NC+   
Sbjct: 509  FVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSC 568

Query: 1535 ECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVG-NCYLKFGPRGDGSLSC 1593
             C +      G C +  G   C CPP         GC     G +C  K      G   C
Sbjct: 569  SCQN-----GGTCDSVTG--ACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRG--RC 619

Query: 1594 NTEIGVGVSRSSCCCSLGKAWGNPCE-TCPPVNSTEYYTLCPGGEGFRPNPITIILEDID 1652
            +   G      +C C  G  +G  C  TCPP      +   PG                +
Sbjct: 620  HRLYG------ACLCDPG-LYGRFCHLTCPP------WAFGPGCS--------------E 652

Query: 1653 ECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTL 1712
            ECQ +    Q  +C    GS  C C  G+        CE         G  GPG C+   
Sbjct: 653  ECQCVQPHTQ--SCDKRDGS--CSCKAGFRGERCQAECE--------LGYFGPG-CWQ-- 697

Query: 1713 GNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAW 1772
                C CP      +    C       C   + G  C  E P          T+ V  + 
Sbjct: 698  ---ACTCPVGVACDSVSGEC----GKRCPAGFQGEDCGQECPVG--------TFGVNCSS 742

Query: 1773 NKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDID--------ECKEIPGICANGV- 1823
            +  C   P  G       C   PG      TG+  + D         C+EI   C +   
Sbjct: 743  SCSCGGAPCHGVTG---QCRCPPG-----RTGEDCEADCPEGRWGLGCQEICPACQHAAR 794

Query: 1824 CINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINS----PGSYRCECA 1879
            C  + G+  C C  GF  +     C+D+         CQ    C N     P +  C CA
Sbjct: 795  CDPETGA--CLCLPGFVGSR----CQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCA 848

Query: 1880 AGFK-LSPNGACVDRNECLEIPNVCS----HGLCVDLQGSYQCICHNGFKASQDQTMCMD 1934
             G+   S   AC   +   +  + C+    HG C  + G   C+C  G+   + +  C  
Sbjct: 849  PGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISG--LCLCEAGYVGPRCEQQCPQ 906

Query: 1935 ---VDECE-RHPCGNG-TCKNTVGSYNC-----------LCYPGFELTHNNDCLDIDECS 1978
                  CE R  C +G  C +  G+  C            C  GF      DC     C+
Sbjct: 907  GHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGF---FGLDCRSACNCT 963

Query: 1979 SFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPG-SCSP--GTCQNL 2035
            +       NG C    G     C E       G NC  +  C    G SC P  G C   
Sbjct: 964  AGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNC--SQACACFNGASCDPVHGQCHCA 1021

Query: 2036 EG----SFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSD 2091
             G    S    CP G  +  +NC     C         G+C    G   C CP G+    
Sbjct: 1022 PGWMGPSCLQACPAG--LYGDNCRHSCLCQNG------GTCDPVSG--HCACPEGWAGLA 1071

Query: 2092 NGRRCF--DTR-----QSFCFT----NFENGKCSVPKAFNTTKAKCCCSKMPGEGW-GDP 2139
              + C   D R        C      +   G+C  P  +   K +  C +    GW G+ 
Sbjct: 1072 CEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLR----GWFGEA 1127

Query: 2140 CELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCE-- 2197
            C         A +  CP G     + H        C   PG   +G          CE  
Sbjct: 1128 C---------AQRCSCPPG----AACHHV---TGACRCPPGFTGSG----------CEQA 1161

Query: 2198 CPMGYNLDYTGVRCVDTDECSIGNPC---GNGTCTNVIGSFECNCNEGFEPGPM-MNCED 2253
            CP G      G  C    +C   NP      GTC+   G    +C +   PG     CE 
Sbjct: 1162 CPPG----SFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQ 1217

Query: 2254 INECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCE-SRGMMC 2312
            +  C     L    C    G+  C CP G+   +    C          H C   +G  C
Sbjct: 1218 LCGC-----LNGGSCDAATGA--CRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAAC 1270

Query: 2313 KNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGI-CENGRCVNIIG---SYRCECNEG 2368
              + GT  C+CPPG A                  G+ CE G   N  G    + C C  G
Sbjct: 1271 DPVTGT--CLCPPGRA------------------GVRCERGCPQNRFGVGCEHTCSCRNG 1310

Query: 2369 FQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGW-GHQCELCPL 2427
                           GLC A                 +   C C  G GW G  CEL   
Sbjct: 1311 ---------------GLCHA-----------------SNGSCSC--GLGWTGRHCELA-- 1334

Query: 2428 PGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRC-------FCKVGY 2480
                     CP        GR    C +  +   N  C    G+ RC        C+   
Sbjct: 1335 ---------CP-------PGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPC 1378

Query: 2481 TTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQ 2540
                 G  C  L  C Q   PC+ I      S +C CP G+     G  C+   E  +  
Sbjct: 1379 PPGFHGAGCQGLCWC-QHGAPCDPI------SGRCLCPAGF----HGHFCERGCEPGSFG 1427

Query: 2541 HNCQFLCVNTLGGFTCK-------CPPGFT-----------QHHTACIDNNECGSQPSLC 2582
              C   C +  GG  C        CPPG +           Q   +C  + +CG      
Sbjct: 1428 EGCHQRC-DCDGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCD 1486

Query: 2583 GAKGICQNTPGSFSCECQRG 2602
               G C    G     C+ G
Sbjct: 1487 PVSGQCHCVDGYMGPTCREG 1506



 Score =  290 bits (742), Expect = 1e-77
 Identities = 380/1508 (25%), Positives = 529/1508 (35%), Gaps = 304/1508 (20%)

Query: 502  ANLCLNG-RCIPTVSSYRCECNMGYKQDANGDC-IDVDEC-TSNPCTNGDCVNTPGSYYC 558
            A+LC +G RC+P  S+  C C  G++      C  DVDEC T N      CVNTPGSY C
Sbjct: 130  ASLCFHGGRCVPG-SAQPCHCPPGFQGPR---CQYDVDECRTHNGGCQHRCVNTPGSYLC 185

Query: 559  KCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDH 618
            +C  GF+     + C+ I+ C      C++     T    +C C  GF+L  DG++CV  
Sbjct: 186  ECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRR 245

Query: 619  DECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGH-CINSE 677
              C   N      C    G  +C C  G+ LA +G+ C DVDEC   G+    H C+N++
Sbjct: 246  SPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAA-GLAQCAHGCLNTQ 304

Query: 678  GSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGF 737
            GSF+C C  G  +G DGR C    M          G C              C++   G 
Sbjct: 305  GSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHG-----------CSHTSAG- 352

Query: 738  GEPCQPCPAKNSAEFHGLCSSGVGITVDGR---DINECALDPDICANGICENLRGSYRCN 794
              P   CP             G  +  D R   D+++CA  P  C   +C N  G Y C 
Sbjct: 353  --PLCTCPR------------GYELDTDQRTCIDVDDCADSP--CCQQVCTNNPGGYECG 396

Query: 795  CNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDIN 854
            C +GY   A G  C D+DEC  +R  C++  C N  GS+ C+C  GY    +   C  + 
Sbjct: 397  CYAGYRLSADGCGCEDVDECASSRGGCEHH-CTNLAGSFQCSCEAGYRLHEDRRGCSPLE 455

Query: 855  ECESN-----PCVNGACR--------------NNLGSFNCECS-PGSKLSSTGLICIDSL 894
            E   +     P V                   +++G+   E    G    +   +C+D  
Sbjct: 456  EPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDS 515

Query: 895  KG-TCWLNIQDSRCEVNINGAT--LKSECCATLGAAWGSPC-ERCELDTACPRGLARIKG 950
             G  C L   D R     NG T  L  + C       G  C E C  DT    G      
Sbjct: 516  FGHDCSLTCDDCR-----NGGTCLLGLDGCDCPEGWTGLICNETCPPDTF---GKNCSFS 567

Query: 951  VTCEDVNECEVFPGVCPNGRCVNSKGSFHCE--CPEGLTLDGTGRVCLDIRMEQCYLKWD 1008
             +C++   C+   G C   RC       +CE  CP+G       + C      +C+  + 
Sbjct: 568  CSCQNGGTCDSVTGAC---RCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYG 624

Query: 1009 EDECIHPVPGKFRMDAC-CCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTG 1067
               C   + G+F    C   A G     EC +C +P T+     C +  G  +       
Sbjct: 625  ACLCDPGLYGRFCHLTCPPWAFGPGCSEEC-QCVQPHTQS----CDKRDGSCS------- 672

Query: 1068 RPFYKDINECKA-FPGMCTYGKCRNTIGSF------KCRCNSGFALDMEERNCTDIDECR 1120
                     CKA F G     +C   +G F       C C  G A D     C       
Sbjct: 673  ---------CKAGFRGERCQAECE--LGYFGPGCWQACTCPVGVACDSVSGECGKRCPAG 721

Query: 1121 ISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGS 1180
               + CG    V T G                  NC     C      C G  C    G 
Sbjct: 722  FQGEDCGQECPVGTFG-----------------VNCS--SSCS-----CGGAPCHGVTG- 756

Query: 1181 FQCDCPLGHELSPSREDCVDINECSLSDNLC----RNGKCVNMIGTYQCSCNPGYQATPD 1236
             QC CP G        DC +         +C       +C    G   C C PG+  +  
Sbjct: 757  -QCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGA--CLCLPGFVGS-- 811

Query: 1237 RQGCTDIDECMIMNGGCDTQCTNSEGSY------ECSCSEGYALMPDGRSCAD---IDEC 1287
               C D+         C T+C+ +   +       CSC+ G+      R+C       +C
Sbjct: 812  --RCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDC 869

Query: 1288 ENNPDICDG--GQCTNIPGEYRCLCYDGFMASMDMKTCIDVN---ECDLNSNICMFGECE 1342
             ++P  C    G C  I G   CLC  G++     + C   +    C+          C+
Sbjct: 870  -SHPCNCSAGHGSCDAISG--LCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACD 926

Query: 1343 NTKGSFICHCQLGYSVKKGT-------TGCTDVDECEIGAHNCDMHASCLNIPGSFKCSC 1395
            +  G+  C C  G+   +GT        G   +D C   A NC   A+C  + GS  C C
Sbjct: 927  HVSGA--CTCPAGW---RGTFCEHACPAGFFGLD-CR-SACNCTAGAACDAVNGS--CLC 977

Query: 1396 REGWIGNGIKCIDLDECSNGTHQCSINAQCVN----TPGSYRCACSEGFTGDGFTCSDV- 1450
              G    G +C +        H CS    C N     P   +C C+ G+ G   +C    
Sbjct: 978  PAG--RRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGP--SCLQAC 1033

Query: 1451 ------DECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDID---ECSFQNIC 1501
                  D C  +  LC+NG   + P +  C C  G+   +  + C   D    C     C
Sbjct: 1034 PAGLYGDNCRHSC-LCQNGGTCD-PVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGC 1091

Query: 1502 V-FGTCNNLPGMFHCICDDGYELDRTGGNCTD---IDECADPINCVNG-LCVNTPGRYEC 1556
            +  G C+  P    C+C  G+  D+    C      + CA   +C  G  C +  G   C
Sbjct: 1092 LNGGLCD--PHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTG--AC 1147

Query: 1557 NCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGN 1616
             CPP F  +     C     G    +       + +C+   G      +C C+ G    +
Sbjct: 1148 RCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATG------TCSCAAGYHGPS 1201

Query: 1617 PCETCPPVN---STEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSF 1673
              + CPP       E    C  G                 C    G C+   C   F   
Sbjct: 1202 CQQRCPPGRYGPGCEQLCGCLNG---------------GSCDAATGACR---CPTGFLGT 1243

Query: 1674 QCE--CPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPP---------- 1721
             C   CPQG +    T +C            CG G   + +   TC+CPP          
Sbjct: 1244 DCNLTCPQGRFGPNCTHVCG-----------CGQGAACDPVTG-TCLCPPGRAGVRCERG 1291

Query: 1722 ---EYMQVNGGHNCMDMRKSFCYRS---------YNGTTCENELP---FNVTKRMCCCTY 1766
                   V   H C       C+ S         + G  CE   P   +     + C  +
Sbjct: 1292 CPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCH 1351

Query: 1767 NVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCIN 1826
            N     N  CE  P  GT      CG  PGF      G+A +        G    G+C  
Sbjct: 1352 N-----NSTCE--PATGTCR----CG--PGF-----YGQACEHPCPPGFHGAGCQGLCWC 1393

Query: 1827 QIG------SFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAA 1880
            Q G      S RC CP GF  +     CE   E  +    C +  DC    G   C+   
Sbjct: 1394 QHGAPCDPISGRCLCPAGFHGH----FCERGCEPGSFGEGCHQRCDC---DGGAPCDPVT 1446

Query: 1881 GFKLSPNG 1888
            G  L P G
Sbjct: 1447 GLCLCPPG 1454



 Score =  259 bits (661), Expect = 4e-68
 Identities = 377/1506 (25%), Positives = 512/1506 (33%), Gaps = 298/1506 (19%)

Query: 1344 TKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFK-CSCREGWIGN 1402
            T+   +  C  G+  +    GC      E  A  C     C  +PGS + C C  G+   
Sbjct: 102  TEARTVLRCCRGWMQQPDEEGCLSA---ECSASLCFHGGRC--VPGSAQPCHCPPGF--Q 154

Query: 1403 GIKC-IDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT--GDGFTCSDVDECAENINL 1459
            G +C  D+DEC   TH      +CVNTPGSY C C  GF    D  TC  ++ CA     
Sbjct: 155  GPRCQYDVDECR--THNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGG 212

Query: 1460 CENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDD 1519
            C++         +RC+C  GF    D R C     C+ +N      C  + G+  C C  
Sbjct: 213  CQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHV 272

Query: 1520 GYELDRTGGNCTDIDECADPI-NCVNGLCVNTPGRYECNCPPDFQLNPTGVGC--VDNRV 1576
            GY+L   G  C D+DECA  +  C +G C+NT G ++C C   ++L   G  C  ++  +
Sbjct: 273  GYQLAADGKACEDVDECAAGLAQCAHG-CLNTQGSFKCVCHAGYELGADGRQCYRIEMEI 331

Query: 1577 GNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGG 1636
             N             SC    G G S      S G     P  TCP              
Sbjct: 332  VN-------------SCEANNG-GCSHGCSHTSAG-----PLCTCP-------------- 358

Query: 1637 EGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDEC 1696
             G+  +       D+D+C + P  C    C N  G ++C C  GY LS D   CED+DEC
Sbjct: 359  RGYELDTDQRTCIDVDDCADSP--CCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDEC 416

Query: 1697 FAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPF- 1755
             +  G C    C N  G++ C C   Y        C  + +            + ELPF 
Sbjct: 417  ASSRGGC-EHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPM-------VDLDGELPFV 468

Query: 1756 NVTKRMCCCTYNVGKAWNKPC-----EPCPTPG--TADFKTICGNIPGFTFDIHTGKAVD 1808
                 +      + + +         E     G  T   K +C +   F  D     ++ 
Sbjct: 469  RPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLD-DSFGHDC----SLT 523

Query: 1809 IDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDI-------DECSNGDNLC 1861
             D+C+        G C+  +G   C+CP G++     L+C +          CS   + C
Sbjct: 524  CDDCRN------GGTCL--LGLDGCDCPEGWTG----LICNETCPPDTFGKNCSFSCS-C 570

Query: 1862 QRNADCINSPGSYRC-------ECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGS 1914
            Q    C +  G+ RC        C  G      G       C +  N  + G C  L G+
Sbjct: 571  QNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYG-----KHCRKKCNCANRGRCHRLYGA 625

Query: 1915 YQCICHNGFKASQDQTMCMD-------VDECERHPCGNGTCKNTVGSYNCLCYPGFELTH 1967
              C+C  G         C          +EC+       +C    GS  C C  GF    
Sbjct: 626  --CLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGS--CSCKAGFR--- 678

Query: 1968 NNDCLDIDECS-SFFGQVCRNG-------RCFNEIGSFKCLCNEGYELTPDGKNCIDTNE 2019
               C    EC   +FG  C           C +  G     C  G++    G+ C     
Sbjct: 679  GERCQA--ECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTF 736

Query: 2020 CVALPGSCSPG--TCQNLEGSFRCICPPGYEVKSENC-IDINE------CDEDPNICLFG 2070
             V    SCS G   C  + G  +C CPPG     E+C  D  E      C E    C   
Sbjct: 737  GVNCSSSCSCGGAPCHGVTG--QCRCPPGRT--GEDCEADCPEGRWGLGCQEICPACQHA 792

Query: 2071 SCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSK 2130
            +  +   G  CLC PGFV    G RC D   +  +      +CS     +   A   CS 
Sbjct: 793  ARCDPETG-ACLCLPGFV----GSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSC 847

Query: 2131 MPGEGW-GDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICS--NGQC 2187
             PG  W G  C           Q  C  GH      H        C    G C   +G C
Sbjct: 848  APG--WTGFSC-----------QRACDTGHWGPDCSHPCN-----CSAGHGSCDAISGLC 889

Query: 2188 INTDGSF--RCE--CPMGYNLDYTGVRCVDTDECSIGNPCGN--GTCTNVIGSFECNCNE 2241
            +   G    RCE  CP G+     G  C    +C  G  C +  G CT   G     C  
Sbjct: 890  LCEAGYVGPRCEQQCPQGH----FGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEH 945

Query: 2242 GFEPGPM-MNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAE 2300
                G   ++C     C          C    GS  C CP G   R   +  +       
Sbjct: 946  ACPAGFFGLDCRSACNCTAGAA-----CDAVNGS--CLCPAG---RRGPRCAETCPAHTY 995

Query: 2301 GLHDCES-----RGMMCKNLIGTFMCICPPGMARRPDGEGC---VDENECRTKPGICENG 2352
            G H+C        G  C  + G   C C PG       + C   +  + CR    +C+NG
Sbjct: 996  G-HNCSQACACFNGASCDPVHG--QCHCAPGWMGPSCLQACPAGLYGDNCRHSC-LCQNG 1051

Query: 2353 RCVNIIGSYRCECNEGFQSSSSGTECLDN-------------RQGLCFAEVLQTICQMAS 2399
               + +  + C C EG+   +   ECL                 GLC     + +C    
Sbjct: 1052 GTCDPVSGH-CACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGW 1110

Query: 2400 SSRNLVTKSECCCDGGRGW-GHQCEL---CPLPGTAQYKKICPHGPGYTTDGRDIDECKV 2455
                  T  +C     RGW G  C     CP PG A     C H  G          C+ 
Sbjct: 1111 ------TGDKCQSPCLRGWFGEACAQRCSCP-PGAA-----CHHVTG---------ACRC 1149

Query: 2456 MPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQC 2515
             P    +G            C+        G  C  + +C       N  C    G+  C
Sbjct: 1150 PPGFTGSG------------CEQACPPGSFGEDCAQMCQCPGE----NPACHPATGT--C 1191

Query: 2516 SCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGF------TCKCPPGF--TQHHT 2567
            SC  GY     G +C+           C+ LC    GG        C+CP GF  T  + 
Sbjct: 1192 SCAAGY----HGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNL 1247

Query: 2568 ACIDNN---------ECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC 2618
             C              CG   +     G C   PG     C+RG   +  G+ CE    C
Sbjct: 1248 TCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSC 1307

Query: 2619 DGN---HRCQHGCQNILG--GYRC--GCPQGYIQHYQWNQCVDENECSNPNACGSASCYN 2671
                  H     C   LG  G  C   CP G        +C   N  +   A G+  C  
Sbjct: 1308 RNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGP 1367

Query: 2672 TLGSYKC--ACPSGFSFDQFSSACHDVNECSSSK--NPCNYGCSNTEG--GYLC--GCPP 2723
                  C   CP GF      + C  +  C      +P +  C    G  G+ C  GC P
Sbjct: 1368 GFYGQACEHPCPPGF----HGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEP 1423

Query: 2724 GYYRVG 2729
            G +  G
Sbjct: 1424 GSFGEG 1429



 Score =  251 bits (641), Expect = 7e-66
 Identities = 375/1572 (23%), Positives = 511/1572 (32%), Gaps = 347/1572 (22%)

Query: 178  PVCENGCQNGGRCIGPNRCACVY-GFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTK 236
            PV + GC     C+G  R    Y G+             C      Q  +       C+ 
Sbjct: 71   PVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEGCLSAECSA 130

Query: 237  TLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQ-DVDECQAIPGICQGGNCINT 295
            +LC         H     P   QPC     P  +   CQ DVDEC+   G CQ   C+NT
Sbjct: 131  SLCF--------HGGRCVPGSAQPCHCP--PGFQGPRCQYDVDECRTHNGGCQH-RCVNT 179

Query: 296  VGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDG 355
             GS+ C C  G +    ++ C  I+ C++  G C+      T+  + C C  G+    DG
Sbjct: 180  PGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDG 239

Query: 356  SRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRR 415
              C+  R   C +   NG C           +C C  G                     +
Sbjct: 240  RHCV--RRSPCANR--NGSCMHRCQVVRGLARCECHVG--------------------YQ 275

Query: 416  LCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAG 475
            L  DG     +   A          G A   +G                 G    V  AG
Sbjct: 276  LAADGKACEDVDECAA---------GLAQCAHG------------CLNTQGSFKCVCHAG 314

Query: 476  VGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDAN-GDCI 534
               G  G     + +  + ++ C+ +   C +G C  T +   C C  GY+ D +   CI
Sbjct: 315  YELGADGRQCYRIEM--EIVNSCEANNGGCSHG-CSHTSAGPLCTCPRGYELDTDQRTCI 371

Query: 535  DVDECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNT 594
            DVD+C  +PC    C N PG Y C C+AG++ +     C D+DEC  +   C++  C N 
Sbjct: 372  DVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEH-HCTNL 430

Query: 595  DGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFV------ 648
             GSFQC C AG+ L  D + C   +E            ++ DG    +     +      
Sbjct: 431  AGSFQCSCEAGYRLHEDRRGCSPLEE----------PMVDLDGELPFVRPLPHIAVLQDE 480

Query: 649  ---LAPNGRYCTDVDECQTPG-ICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRS 704
               L  +     D +E +  G   +    +  + SF  DC            C D     
Sbjct: 481  LPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDC---------SLTCDDCRNGG 531

Query: 705  TCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITV 764
            TC  G+    C   + G +    C    P   FG+ C          F   C +G     
Sbjct: 532  TCLLGLDGCDCPEGWTGLICNETC----PPDTFGKNC---------SFSCSCQNG----- 573

Query: 765  DGRDINECALDPDICANGICENLRGSYRC-------NCNSGYEPDASGRNCIDIDECLVN 817
                             G C+++ G+ RC       NC  G      G++C     C  N
Sbjct: 574  -----------------GTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNC-AN 615

Query: 818  RLLCDN--GLCRNTPGSYS----CTCPPGYVFRTETETCEDIN-ECESNPCVNGACRNNL 870
            R  C    G C   PG Y      TCPP       +E C+ +    +S    +G+C    
Sbjct: 616  RGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKA 675

Query: 871  GSFNCECSPGSKLSSTGLIC-----------IDSLKGTCWLNIQDSRCEVNINGATLKSE 919
            G     C    +L   G  C            DS+ G C       RC     G     E
Sbjct: 676  GFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGEC-----GKRCPAGFQGEDCGQE 730

Query: 920  C--------CATLGAAWGSPC---------------ERCELDTACPRGLARIKGVTCEDV 956
            C        C++  +  G+PC               E CE D  CP G     G+ C+++
Sbjct: 731  CPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEAD--CPEGR---WGLGCQEI 785

Query: 957  --------------NECEVFPG--------VCPNG----------RCVNS----KGSFHC 980
                            C   PG        VCP G           C N       + HC
Sbjct: 786  CPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHC 845

Query: 981  ECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPV---PGKFRMDA----CCCAVGAAW 1033
             C  G T     R C D         W  D C HP     G    DA    C C  G   
Sbjct: 846  SCAPGWTGFSCQRAC-DTG------HWGPD-CSHPCNCSAGHGSCDAISGLCLCEAGYV- 896

Query: 1034 GTECE-ECPK----PGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGK 1088
            G  CE +CP+    PG  E    C  GA   +     T    ++      A P       
Sbjct: 897  GPRCEQQCPQGHFGPGC-EQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLD 955

Query: 1089 CRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPG---SFECECFEG 1145
            CR+      C C +G A D    +C      R  P  C      +T G   S  C CF G
Sbjct: 956  CRSA-----CNCTAGAACDAVNGSCL-CPAGRRGP-RCAETCPAHTYGHNCSQACACFNG 1008

Query: 1146 ----------YESGFMMMKNCMDI-------DECERNPLLCRGGTCVNTEGSFQCDCPLG 1188
                      + +   M  +C+         D C  + L   GGTC    G   C CP G
Sbjct: 1009 ASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSG--HCACPEG 1066

Query: 1189 HELSPSREDCV--DINE-CSLSDNLCRNGKCVNMIGTYQCSCNPGY-------------- 1231
                   ++C+  D+   C  S      G C    G  +C C  G+              
Sbjct: 1067 WAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTG--RCLCPAGWTGDKCQSPCLRGWF 1124

Query: 1232 -QATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENN 1290
             +A   R  C     C  + G C      +    E +C  G      G  CA + +C   
Sbjct: 1125 GEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPG----SFGEDCAQMCQCPGE 1180

Query: 1291 PDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVN---ECDLNSNICMFGECENTKGS 1347
               C        P    C C  G+      + C        C+        G C+   G+
Sbjct: 1181 NPACH-------PATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGA 1233

Query: 1348 FICHCQLGY-------SVKKGTTG--CTDVDECEIGAHNCDMHASCLNIPGSFKCSCREG 1398
              C C  G+       +  +G  G  CT V  C  GA    +  +CL  PG     C  G
Sbjct: 1234 --CRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERG 1291

Query: 1399 WIGN--GIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGD-----------GF 1445
               N  G+ C     C NG         C  + GS  C+C  G+TG            G 
Sbjct: 1292 CPQNRFGVGCEHTCSCRNG-------GLCHASNGS--CSCGLGWTGRHCELACPPGRYGA 1342

Query: 1446 TCSDVDECAENINLCE--NGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNIC-- 1501
             C     C  N + CE   G C   PG Y   CE    P      CQ +  C     C  
Sbjct: 1343 ACHLECSCHNN-STCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDP 1401

Query: 1502 VFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDEC--ADPINCVNGLCVNTPGRYECNCP 1559
            + G C    G     C+ G E    G  C    +C    P + V GLC+  PGR    C 
Sbjct: 1402 ISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCN 1461

Query: 1560 PDFQLNPTGVGC 1571
             D +    G  C
Sbjct: 1462 LDCRRGQFGPSC 1473



 Score =  158 bits (400), Expect = 6e-38
 Identities = 360/1518 (23%), Positives = 490/1518 (32%), Gaps = 359/1518 (23%)

Query: 119  CGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDH---CQCQKGYIGTYC 175
            C  G+  +P+   C S + S++            C +GG C       C C  G+ G  C
Sbjct: 110  CCRGWMQQPDEEGCLSAECSASL-----------CFHGGRCVPGSAQPCHCPPGFQGPRC 158

Query: 176  GQPVCENGCQNGG---RCI---GPNRCACVYGFTGPQCERDYRTGPCFTQ--VNNQMCQG 227
               V E    NGG   RC+   G   C C  GF   +   D RT        + N  CQ 
Sbjct: 159  QYDVDECRTHNGGCQHRCVNTPGSYLCECKPGF---RLHTDSRTCLAINSCALGNGGCQH 215

Query: 228  QLTGIVCTKTLC--------------------CATIGRAWGHPCEMCPAQPQ-PCRRGFI 266
                +  T+  C                    CA    +  H C++     +  C  G+ 
Sbjct: 216  HCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQ 275

Query: 267  PNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHK------------------ 308
                  AC+DVDEC A    C  G C+NT GSF+C C AG++                  
Sbjct: 276  LAADGKACEDVDECAAGLAQCAHG-CLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNS 334

Query: 309  ---------------------------QSETTQK-CEDIDECSIIPGICETGECSNTVGS 340
                                       + +T Q+ C D+D+C+  P  C    C+N  G 
Sbjct: 335  CEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSP--CCQQVCTNNPGG 392

Query: 341  YFCVCPRGYVTSTDGSRCID------QRTGM---CFSGLVNGRCAQELPGRMTKMQCCCE 391
            Y C C  GY  S DG  C D       R G    C +   + +C+ E   R+ + +  C 
Sbjct: 393  YECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCS 452

Query: 392  P---------GRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGF 442
            P         G    +  +P    ++  +E  +L  D   +G     A  R   T    F
Sbjct: 453  PLEEPMVDLDGELPFVRPLPHIAVLQ--DELPQLFQDD-DVGADEEEAELRGEHTLTEKF 509

Query: 443  APSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHA 502
                +  G+    T      GG     G+ G     G  G +I   T    T       +
Sbjct: 510  VCLDDSFGHDCSLTCDDCRNGGTCLL-GLDGCDCPEGWTG-LICNETCPPDTFGKNCSFS 567

Query: 503  NLCLNG----------RCIPTVSSYRCE--CNMGY-----KQDANGDCIDVDECTSNPCT 545
              C NG          RC P VS   CE  C  GY     ++  N  C +   C      
Sbjct: 568  CSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCN--CANRGRCHR---L 622

Query: 546  NGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAG 605
             G C+  PG Y   CH           C +  +C+Q         C   DGS  C C AG
Sbjct: 623  YGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQP----HTQSCDKRDGS--CSCKAG 676

Query: 606  FELTTDGKNCVDHDE-------CTTTNMCLNGM-CINEDGSFKCICKPGFVLAPNGRYC- 656
            F     G+ C    E       C     C  G+ C +  G     C  GF     G+ C 
Sbjct: 677  FR----GERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECP 732

Query: 657  --TDVDECQTPGICMNGHCINSEGSFRC-----------DCPPGLAVGMDGRVCVDTHMR 703
              T    C +   C    C    G  RC           DCP G        +C      
Sbjct: 733  VGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHA 792

Query: 704  STCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQP-CPAKNSAEFH---GLCSSG 759
            + C       +C+  F G+  +  C    P   +G  CQ  C   N    H   G CS  
Sbjct: 793  ARCDPETGACLCLPGFVGSRCQDVC----PAGWYGPSCQTRCSCANDGHCHPATGHCSCA 848

Query: 760  VGITV--------DGRDINECALDPDICA--NGICENLRGSYRCNCNSGYEPDASGRNCI 809
             G T          G    +C+  P  C+  +G C+ + G   C C +GY      + C 
Sbjct: 849  PGWTGFSCQRACDTGHWGPDCS-HPCNCSAGHGSCDAISGL--CLCEAGYVGPRCEQQCP 905

Query: 810  D--IDECLVNRLLCDNGL-CRNTPGSYSCTCPPGY------------VFRTETETCEDIN 854
                      R  C +G  C +  G+  CTCP G+             F  +  +  +  
Sbjct: 906  QGHFGPGCEQRCQCQHGAACDHVSGA--CTCPAGWRGTFCEHACPAGFFGLDCRSACNCT 963

Query: 855  ECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLIC-----------IDSLKGTC----- 898
               +   VNG+C    G     C+      + G  C            D + G C     
Sbjct: 964  AGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPG 1023

Query: 899  WLNIQDSR-CEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVN 957
            W+     + C   + G   +  C    G      C+      ACP G A   G+ CE   
Sbjct: 1024 WMGPSCLQACPAGLYGDNCRHSCLCQNGGT----CDPVSGHCACPEGWA---GLACE--K 1074

Query: 958  EC---EVFPGVCPNGRCVNS----KGSFHCECPEGLTLDGTGRVCL-----DIRMEQCYL 1005
            EC   +V  G   +G C+N       +  C CP G T D     CL     +   ++C  
Sbjct: 1075 ECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRC-- 1132

Query: 1006 KWDEDECIHPVPGKFRMDACCCAVG------------AAWGTECEE---CP--KPGTKEY 1048
                    H V G     AC C  G             ++G +C +   CP   P     
Sbjct: 1133 SCPPGAACHHVTG-----ACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPA 1187

Query: 1049 ETLCPRGAGFANRGDVLTGR-PFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALD 1107
               C   AG+   G     R P  +    C+   G    G C    G+  CRC +GF   
Sbjct: 1188 TGTCSCAAGY--HGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGA--CRCPTGFLGT 1243

Query: 1108 MEERNCTDIDECRISPDL-----CGSGICVNTPGSFECECFEGYESGFMMMKNCMDID-- 1160
                 C    + R  P+      CG G   + P +  C C  G  +G    + C      
Sbjct: 1244 DCNLTCP---QGRFGPNCTHVCGCGQGAACD-PVTGTCLCPPG-RAGVRCERGCPQNRFG 1298

Query: 1161 -ECERNPLLCRGGTCVNTEGSFQCDCPLGH-----ELS--PSREDCVDINECSLSDNLCR 1212
              CE       GG C  + GS  C C LG      EL+  P R       ECS  +N   
Sbjct: 1299 VGCEHTCSCRNGGLCHASNGS--CSCGLGWTGRHCELACPPGRYGAACHLECSCHNN--- 1353

Query: 1213 NGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGY 1272
               C    GT  C C PG+      Q C           GC   C    G+  C    G 
Sbjct: 1354 -STCEPATGT--CRCGPGFYG----QACEHPCPPGFHGAGCQGLCWCQHGA-PCDPISGR 1405

Query: 1273 ALMPDG-------RSCADI---DECENNPDICDGGQ-CTNIPGEYRCLCYDGFMASMDMK 1321
             L P G       R C      + C    D CDGG  C  + G   CLC  G   +    
Sbjct: 1406 CLCPAGFHGHFCERGCEPGSFGEGCHQRCD-CDGGAPCDPVTG--LCLCPPGRSGAT--- 1459

Query: 1322 TCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCD-M 1380
                   C+L+     FG       S   HC  G                  G  +CD +
Sbjct: 1460 -------CNLDCRRGQFGP------SCTLHCDCG------------------GGADCDPV 1488

Query: 1381 HASCLNIPGSFKCSCREG 1398
               C  + G    +CREG
Sbjct: 1489 SGQCHCVDGYMGPTCREG 1506



 Score =  152 bits (385), Expect = 4e-36
 Identities = 252/1076 (23%), Positives = 339/1076 (31%), Gaps = 212/1076 (19%)

Query: 577  DECIQNGVLCKNGR--CVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMC--LNGMC 632
            D+C +NG  C  G   C   +G    ICN      T GKNC     C     C  + G C
Sbjct: 525  DDC-RNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGAC 583

Query: 633  INEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGIC--MNGHCINSEGSF----RCDCPP 686
                G     C+ G      G++C     C   G C  + G C+   G +       CPP
Sbjct: 584  RCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPP 643

Query: 687  -GLAVGMDGRV-CVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPC 744
                 G      CV  H +S C        C   F G   ++EC       G  + C  C
Sbjct: 644  WAFGPGCSEECQCVQPHTQS-CDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACT-C 701

Query: 745  PAKNSAE-FHGLCSSGVGITVDGRDIN-ECAL--------DPDICANGICENLRGSYRC- 793
            P   + +   G C         G D   EC +            C    C  + G  RC 
Sbjct: 702  PVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCP 761

Query: 794  ------NCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTET 847
                  +C +       G  C +I     +   CD       P + +C C PG+V     
Sbjct: 762  PGRTGEDCEADCPEGRWGLGCQEICPACQHAARCD-------PETGACLCLPGFV----G 810

Query: 848  ETCEDI-------NECESN-PCVN-GACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTC 898
              C+D+         C++   C N G C    G  +C C+PG     TG  C        
Sbjct: 811  SRCQDVCPAGWYGPSCQTRCSCANDGHCHPATG--HCSCAPGW----TGFSC-------- 856

Query: 899  WLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNE 958
                    C+    G      C  + G      C+       C  G     G  CE    
Sbjct: 857  -----QRACDTGHWGPDCSHPCNCSAGHG---SCDAISGLCLCEAGYV---GPRCEQQ-- 903

Query: 959  CEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVP- 1017
                   CP G          C+C  G   D     C       C   W    C H  P 
Sbjct: 904  -------CPQGH-FGPGCEQRCQCQHGAACDHVSGACT------CPAGWRGTFCEHACPA 949

Query: 1018 GKFRMD---ACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDI 1074
            G F +D   AC C  GAA       C          LCP G       +      +  + 
Sbjct: 950  GFFGLDCRSACNCTAGAACDAVNGSC----------LCPAGRRGPRCAETCPAHTYGHNC 999

Query: 1075 NE-CKAFPGMC---TYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGI 1130
            ++ C  F G      +G+C    G     C       +   NC     C+        G 
Sbjct: 1000 SQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQ------NGGT 1053

Query: 1131 CVNTPGSFECECFEGYESGFMMMKNCMDIDE---CERNPLLCRGGTCVNTEGSFQCDCPL 1187
            C   P S  C C EG+ +G    K C+  D    C  +     GG C    G  +C CP 
Sbjct: 1054 C--DPVSGHCACPEGW-AGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTG--RCLCPA 1108

Query: 1188 GHELSPSREDCVD--INECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDI-- 1243
            G      +  C+     E       C  G   + + T  C C PG+  +   Q C     
Sbjct: 1109 GWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHV-TGACRCPPGFTGSGCEQACPPGSF 1167

Query: 1244 -DEC--MIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADI-------DECENNPDI 1293
             ++C  M    G +  C  + G+  CSC+ GY     G SC            CE     
Sbjct: 1168 GEDCAQMCQCPGENPACHPATGT--CSCAAGY----HGPSCQQRCPPGRYGPGCEQLCGC 1221

Query: 1294 CDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGE---CENTKGSFIC 1350
             +GG C    G   C C  GF+ +    TC         +++C  G+   C+   G+ +C
Sbjct: 1222 LNGGSCDAATGA--CRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLC 1279

Query: 1351 -------HCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNG 1403
                    C+ G    +   GC     C  G      HAS      +  CSC  GW G  
Sbjct: 1280 PPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGL---CHAS------NGSCSCGLGWTGRH 1330

Query: 1404 IKCIDLDECSNGTH--QCSINAQCVNT----PGSYRCACSEGFTGD-----------GFT 1446
             +      C  G +   C +   C N     P +  C C  GF G            G  
Sbjct: 1331 CELA----CPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAG 1386

Query: 1447 CSDVDECAENINLCE--NGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNIC--V 1502
            C  +  C      C+  +G+CL   G +   CE G  P S    C    +C     C  V
Sbjct: 1387 CQGLCWCQHGAP-CDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPV 1445

Query: 1503 FGTCNNLPGM-------------------FHCICDDGYELDRTGGNCTDIDECADP 1539
             G C   PG                     HC C  G + D   G C  +D    P
Sbjct: 1446 TGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGP 1501



 Score =  119 bits (299), Expect = 3e-26
 Identities = 196/756 (25%), Positives = 248/756 (32%), Gaps = 168/756 (22%)

Query: 107  GNQCIVPICRNSCGDGFCS-RPNMCTCSSGQISSTC---------GSKSIQQCSVRCMNG 156
            G Q I P C+++     C      C C  G + S C         G     +CS  C N 
Sbjct: 781  GCQEICPACQHAAR---CDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS--CAND 835

Query: 157  GTC--ADDHCQCQKGYIGTYCGQPVCENG-----------CQNG-GRCIG-PNRCACVYG 201
            G C  A  HC C  G+ G  C Q  C+ G           C  G G C      C C  G
Sbjct: 836  GHCHPATGHCSCAPGWTGFSC-QRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAG 894

Query: 202  FTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAW-GHPCE-MCPAQPQ 259
            + GP+CE+    G  F     Q CQ Q  G  C       T    W G  CE  CPA   
Sbjct: 895  YVGPRCEQQCPQGH-FGPGCEQRCQCQ-HGAACDHVSGACTCPAGWRGTFCEHACPA--- 949

Query: 260  PCRRGFIPNIRTGACQDV--DECQAIPGIC------QGGNCINTVGSFECRCPA---GHK 308
                GF       AC       C A+ G C      +G  C  T       CPA   GH 
Sbjct: 950  ----GFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAET-------CPAHTYGHN 998

Query: 309  QSETT-----QKCEDI-DECSIIPG-----------------------ICETGECSNTVG 339
             S+         C+ +  +C   PG                       +C+ G   + V 
Sbjct: 999  CSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVS 1058

Query: 340  SYFCVCPRGYVTSTDGSRCI--DQRTGMCFS-GLVNGRCAQELPGRMTKMQCCCEPG--- 393
             + C CP G+        C+  D R G   S G +NG       GR     C C  G   
Sbjct: 1059 GH-CACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGR-----CLCPAGWTG 1112

Query: 394  -RCWG---IGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGN 449
             +C      G   EAC  R S      C  G     + G+    PG T G+G   +    
Sbjct: 1113 DKCQSPCLRGWFGEACAQRCS------CPPGAACHHVTGACRCPPGFT-GSGCEQACPPG 1165

Query: 450  GYGPGGTGFIPIPGGN-GFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNG 508
             +G         PG N    P  G     AG  GP         +    C+        G
Sbjct: 1166 SFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGG 1225

Query: 509  RCIPTVSSYRC-------ECNMGYKQDANG-DCIDVDEC----TSNPCTNGDCVNTPGSY 556
             C     + RC       +CN+   Q   G +C  V  C      +P T G C+  PG  
Sbjct: 1226 SCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVT-GTCLCPPGRA 1284

Query: 557  YCKCHAGFQRTPTKQACIDIDECIQNGVLC--KNGRCVNTDGSFQCICNAGFELTTDGKN 614
              +C  G  +      C     C +NG LC   NG C    G     C         G  
Sbjct: 1285 GVRCERGCPQNRFGVGCEHTCSC-RNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAA 1343

Query: 615  CVDHDECTTTNMCLNGMCINEDGSFKC-----------ICKPGFVLAPNGRYCTDVDECQ 663
            C  H EC+  N   N  C    G+ +C            C PGF    +G  C  +  CQ
Sbjct: 1344 C--HLECSCHN---NSTCEPATGTCRCGPGFYGQACEHPCPPGF----HGAGCQGLCWCQ 1394

Query: 664  TPGIC--MNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIK----KGVCVR 717
                C  ++G C+   G     C  G   G  G  C   H R  C GG       G+C+ 
Sbjct: 1395 HGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGC---HQRCDCDGGAPCDPVTGLCLC 1451

Query: 718  P--FPGAVTKSEC--------CCANPDYGFGEPCQP 743
            P    GA    +C        C  + D G G  C P
Sbjct: 1452 PPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDP 1487



 Score = 82.4 bits (202), Expect = 6e-15
 Identities = 82/298 (27%), Positives = 106/298 (35%), Gaps = 69/298 (23%)

Query: 97  CCPGWKTLPGGNQCIVPICRNSC--GDGFCSRP--------NMCTCSSGQISSTCGSKSI 146
           C PG++       C+     NSC  G+G C           + C C  G      G   +
Sbjct: 187 CKPGFRLHTDSRTCLAI---NSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCV 243

Query: 147 QQCSVRCMN-GGTCADD--------HCQCQKGYI----GTYC--------GQPVCENGCQ 185
           ++    C N  G+C            C+C  GY     G  C        G   C +GC 
Sbjct: 244 RRSP--CANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCL 301

Query: 186 NGGRCIGPNRCACVYGFT----GPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCA 241
           N     G  +C C  G+     G QC R         + NN  C                
Sbjct: 302 NTQ---GSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCS--------------- 343

Query: 242 TIGRAWGHPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFE 300
                  H C    A P   C RG+  +     C DVD+C   P  C    C N  G +E
Sbjct: 344 -------HGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSP--CCQQVCTNNPGGYE 394

Query: 301 CRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRC 358
           C C AG++ S     CED+DEC+   G CE   C+N  GS+ C C  GY    D   C
Sbjct: 395 CGCYAGYRLSADGCGCEDVDECASSRGGCE-HHCTNLAGSFQCSCEAGYRLHEDRRGC 451



 Score = 40.0 bits (92), Expect = 0.034
 Identities = 44/152 (28%), Positives = 48/152 (31%), Gaps = 22/152 (14%)

Query: 89   CGSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQ 148
            C   FH   C G      G  C     R  C  GF        C  G     C     Q+
Sbjct: 1378 CPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCH----QR 1433

Query: 149  CSVRCMNGGTC--ADDHCQCQKGYIGTYC------GQ--PVCENGCQ-NGGRCIGP--NR 195
            C   C  G  C      C C  G  G  C      GQ  P C   C   GG    P   +
Sbjct: 1434 CD--CDGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQ 1491

Query: 196  CACVYGFTGPQCERDYRTGPCFTQVNNQMCQG 227
            C CV G+ GP C      GP     N  + QG
Sbjct: 1492 CHCVDGYMGPTCREG---GPLRLPENPSLAQG 1520


>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  276 bits (706), Expect = 2e-73
 Identities = 230/761 (30%), Positives = 313/761 (41%), Gaps = 161/761 (21%)

Query: 1026 CCAVGAAW---GTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPG 1082
            CCA G  W     EC E P+ GT++                           N C+    
Sbjct: 445  CCAAGQQWAIDNDECLEIPESGTED---------------------------NVCRTAQR 477

Query: 1083 MCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRIS-----PDLCGSGICVNTPG- 1136
             C    C + +    C      A + E     D D C IS      D CG G+ V   G 
Sbjct: 478  HC----CVSYLQEKSCMAGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQ 533

Query: 1137 SFECECFEGYESGFMMMKNC-----MDIDECERNPLLCRGGTCVN-TEGSFQCDCPLGHE 1190
            S E     GY    +M+  C     + + E  R P        V+  E + +    LG E
Sbjct: 534  SCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTE 593

Query: 1191 LS-PSREDCVDINEC-SLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGC-------- 1240
               P+     D +EC  L   LC++  C+N +G+Y C+C PG+    D + C        
Sbjct: 594  AELPNSLPGDDQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQ 652

Query: 1241 -------------TDIDECMIM-----------NGGCDTQCTNSEGSYECSCSEGYALMP 1276
                         + +    I            NG C   C+   GS  CSC  GYA+M 
Sbjct: 653  PEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMA 712

Query: 1277 DGRSCADIDECENNPDICDGGQ-CTNIPGEYRC-----LCYDGFMASMDMKTCIDVNECD 1330
            DG SC D DEC      C   Q C N  G + C     LC DG++ +   K C+D+NEC 
Sbjct: 713  DGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRK-CVDINECV 771

Query: 1331 LNSNICMFGE-CENTKGSFICH----CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCL 1385
             + + C  GE C NT GSF C+    C+ GY++K G   C DVDEC +G H C     C 
Sbjct: 772  TDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE--CEDVDECAMGTHTCQPGFLCQ 829

Query: 1386 NIPGSFKCS----CREGWI----GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRC--- 1434
            N  GSF C     C +G++    GN   C+D++EC++ +  C     C+NT GSY C   
Sbjct: 830  NTKGSFYCQARQRCMDGFLQDPEGN---CVDINECTSLSEPCRPGFSCINTVGSYTCQRN 886

Query: 1435 --ACSEGF--TGDGFTCSDVDECAENINLCENGQ-CLNVPGAYRCECEMGFTPASDSRSC 1489
               C+ G+  + DG  C DV+EC   ++ C  GQ C N+PG+YRC+C+ GF   +  R C
Sbjct: 887  PLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGC 946

Query: 1490 QDIDEC--SFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLC 1547
             D++EC  S   +C   TC N  G + C C  G+ L   G  C D++EC +   C +  C
Sbjct: 947  IDVNECWASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRCEDVNEC-EAQRC-SQEC 1003

Query: 1548 VNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCC 1607
             N  G Y+C C   +QL   G  C D  +  C      +G G L     + V  S    C
Sbjct: 1004 ANIYGSYQCYCRQGYQLAEDGHTCTD--IDEC-----AQGAGILCTFRCLNVPGSYQCAC 1056

Query: 1608 CSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLC-QGGNC 1666
               G                  YT+   G            +D+DEC      C +   C
Sbjct: 1057 PEQG------------------YTMTANGRS---------CKDVDECALGTHNCSEAETC 1089

Query: 1667 INTFGSFQC---ECPQGYYLSEDTR----ICEDIDECFAHP 1700
             N  GSF+C   ECP  Y     T+     C D  EC   P
Sbjct: 1090 HNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSP 1130



 Score =  260 bits (664), Expect = 2e-68
 Identities = 223/780 (28%), Positives = 313/780 (40%), Gaps = 171/780 (21%)

Query: 1878 CAAGFKLSPNGACVDRNECLEIP------NVC---SHGLCVDLQGSYQCICHNGFKASQD 1928
            CAAG + +     +D +ECLEIP      NVC       CV       C+   G   +++
Sbjct: 446  CAAGQQWA-----IDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMA--GVLGAKE 498

Query: 1929 QTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNG 1988
               C   D      CG       +  Y   C          DC  +       GQ C + 
Sbjct: 499  GETCGAEDN---DSCG-------ISLYKQCC----------DCCGLGLRVRAEGQSCESN 538

Query: 1989 RCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPG-------SCSPGTCQNLEGSFRC 2041
                         N GY       +C +  E + +P        + +P      E + R 
Sbjct: 539  P------------NLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGRE 586

Query: 2042 ICPPGYEVKSENCI---DINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFD 2098
                G E +  N +   D +EC   P       C NT G + C C PGF L D+GR C  
Sbjct: 587  ALSLGTEAELPNSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRP 646

Query: 2099 TRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYG 2158
                                                  G P +     +     +     
Sbjct: 647  E-------------------------------------GHPPQPEAPQEPALKSEFSQVA 669

Query: 2159 HGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECS 2218
              T+P         N C ++ G C    C    GS  C C  GY +   GV C D DEC 
Sbjct: 670  SNTIPL---PLPQPNTCKDN-GPCKQ-VCSTVGGSAICSCFPGYAIMADGVSCEDQDECL 724

Query: 2219 IG-NPCGNGT-CTNVIGSFEC-----NCNEGFEPGPMMNCEDINECAQNPLLCA--FRCM 2269
            +G + C     C N +GSF C      C +G+       C DINEC  +   C+    C+
Sbjct: 725  MGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCV 784

Query: 2270 NTFGSYEC----TCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMC---- 2321
            NT GS+ C    TC  GYAL++ +  C+D+DECA G H C+  G +C+N  G+F C    
Sbjct: 785  NTLGSFHCYKALTCEPGYALKDGE--CEDVDECAMGTHTCQP-GFLCQNTKGSFYCQARQ 841

Query: 2322 ICPPGMARRPDGEGCVDENECRTKPGICENG-RCVNIIGSYRCE-----CNEGFQSSSSG 2375
             C  G  + P+G  CVD NEC +    C  G  C+N +GSY C+     C  G+ +S  G
Sbjct: 842  RCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDG 900

Query: 2376 TECLDNRQGLCFAEVLQ----TIC---------------QMASSSRNLVTKSECCCDGGR 2416
            T+C+D  +  C   V +     +C               Q  +  R  +  +EC    GR
Sbjct: 901  TKCVDVNE--CETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGR 958

Query: 2417 GWGHQCELCPLPGTAQYKKICPHGPGYTTDGR---DIDECKVMPNLCTNGQCINTMGSFR 2473
               H CE         Y+  C  G     DG+   D++EC+     C+  +C N  GS++
Sbjct: 959  LCQHTCE----NTLGSYRCSCASGFLLAADGKRCEDVNECEA--QRCSQ-ECANIYGSYQ 1011

Query: 2474 CFCKVGYTTDISGTSCIDLDECSQSPK-PCNYICKNTEGSYQCSCP-RGYVLQEDGKTCK 2531
            C+C+ GY     G +C D+DEC+Q     C + C N  GSYQC+CP +GY +  +G++CK
Sbjct: 1012 CYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCK 1071

Query: 2532 DLDECQTKQHNCQ--FLCVNTLGGFTC---KCPPGFTQ------HHTACIDNNECGSQPS 2580
            D+DEC    HNC     C N  G F C   +CPP + Q        T C D  EC + P+
Sbjct: 1072 DVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSPA 1131



 Score =  260 bits (664), Expect = 2e-68
 Identities = 205/717 (28%), Positives = 288/717 (40%), Gaps = 142/717 (19%)

Query: 1594 NTEIGVGVSRSSC-CCSLG---KAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILE 1649
            N   G+ + +  C CC LG   +A G  CE+ P +     + +    EG  P  +  +  
Sbjct: 507  NDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRR 566

Query: 1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCY 1709
              +       + +         S   E      L  D     D DEC   PG      C 
Sbjct: 567  PPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGD-----DQDECLLLPGELCQHLCI 621

Query: 1710 NTLGNYTCICPPEYMQVNGGHNCM--------DMRKSFCYRSYNGTTCENELPFNVTKRM 1761
            NT+G+Y C C P +   + G  C         +  +    +S       N +P       
Sbjct: 622  NTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPL------ 675

Query: 1762 CCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICAN 1821
                            P P P T                       D   CK+       
Sbjct: 676  ----------------PLPQPNTCK---------------------DNGPCKQ------- 691

Query: 1822 GVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCE---- 1877
             VC    GS  C C  G++     + CED DEC  G + C R   C+N+ GS+ C     
Sbjct: 692  -VCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTV 750

Query: 1878 -CAAGFKLSPNGACVDRNECLEIPNVCSHGL-CVDLQGSYQCI----CHNGFKASQDQTM 1931
             CA G+ L+ +  CVD NEC+   + CS G  CV+  GS+ C     C  G+     +  
Sbjct: 751  LCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE-- 808

Query: 1932 CMDVDECER--HPCGNG-TCKNTVGSYNCL----CYPGFELTHNNDCLDIDECSSFFGQV 1984
            C DVDEC    H C  G  C+NT GS+ C     C  GF      +C+DI+EC+S   + 
Sbjct: 809  CEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSL-SEP 867

Query: 1985 CRNG-RCFNEIGSFKC-----LCNEGYELTPDGKNCIDTNECVALPGSCSPG-TCQNLEG 2037
            CR G  C N +GS+ C     +C  GY  + DG  C+D NEC      C  G  C NL G
Sbjct: 868  CRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPG 927

Query: 2038 SFRCICPPGYEVKS--ENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRR 2095
            S+RC C  G++  +    CID+NEC   P      +C NT G ++C C  GF+L+ +G+R
Sbjct: 928  SYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKR 987

Query: 2096 CFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLC 2155
            C D  +       E  +CS             C+ + G                ++Q  C
Sbjct: 988  CEDVNEC------EAQRCSQE-----------CANIYG----------------SYQCYC 1014

Query: 2156 PYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECP-MGYNLDYTGVRCVDT 2214
              G+      H T  D++EC +  GI    +C+N  GS++C CP  GY +   G  C D 
Sbjct: 1015 RQGYQLAEDGH-TCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDV 1073

Query: 2215 DECSIG-NPCGNG-TCTNVIGSFEC---NCNEGFEPGPMMNCE-----DINECAQNP 2261
            DEC++G + C    TC N+ GSF C    C   +       CE     D  EC  +P
Sbjct: 1074 DECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSP 1130



 Score =  253 bits (646), Expect = 2e-66
 Identities = 180/552 (32%), Positives = 241/552 (43%), Gaps = 81/552 (14%)

Query: 2170 EDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCT 2229
            +D +ECL  PG      CINT GS+ C C  G++L   G  C                  
Sbjct: 603  DDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 2230 NVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQ 2289
            +       N      P P   C+D   C Q        C    GS  C+C  GYA+  D 
Sbjct: 663  SEFSQVASNTIPLPLPQPN-TCKDNGPCKQV-------CSTVGGSAICSCFPGYAIMADG 714

Query: 2290 KMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI-----CPPGMARRPDGEGCVDENECRT 2344
              C+D DEC  G HDC SR   C N +G+F C+     C  G       + CVD NEC T
Sbjct: 715  VSCEDQDECLMGAHDC-SRRQFCVNTLGSFYCVNHTVLCADGYILNAHRK-CVDINECVT 772

Query: 2345 KPGICENG-RCVNIIGSYRC---------------------ECNEGFQSSSSGTECLDNR 2382
                C  G  CVN +GS+ C                     EC  G  +   G  C  N 
Sbjct: 773  DLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLC-QNT 831

Query: 2383 QGLCFAEVLQTICQ--MASSSRNLVTKSEC------CCDG----GRGWGHQCELCPLPGT 2430
            +G  + +  Q      +     N V  +EC      C  G         + C+  PL   
Sbjct: 832  KGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPL--- 888

Query: 2431 AQYKKICPHGPGYTTDGR---DIDECKVMPNLCTNGQ-CINTMGSFRCFCKVGYTTDISG 2486
                 IC  G   + DG    D++EC+   + C  GQ C N  GS+RC CK G+  D  G
Sbjct: 889  -----ICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFG 943

Query: 2487 TSCIDLDECSQSP-KPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQF 2545
              CID++EC  SP + C + C+NT GSY+CSC  G++L  DGK C+D++EC+ ++  C  
Sbjct: 944  RGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR--CSQ 1001

Query: 2546 LCVNTLGGFTCKCPPGF--TQHHTACIDNNECGSQPS-LCGAKGICQNTPGSFSCEC-QR 2601
             C N  G + C C  G+   +    C D +EC      LC  +  C N PGS+ C C ++
Sbjct: 1002 ECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFR--CLNVPGSYQCACPEQ 1059

Query: 2602 GFSLDATGLNCEDVDECD-GNHRCQHG--CQNILGGYRC---GCPQGYIQ----HYQWNQ 2651
            G+++ A G +C+DVDEC  G H C     C NI G +RC    CP  Y+Q      +   
Sbjct: 1060 GYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTT 1119

Query: 2652 CVDENECSNPNA 2663
            C D  EC N  A
Sbjct: 1120 CHDFLECQNSPA 1131



 Score =  240 bits (612), Expect = 2e-62
 Identities = 177/573 (30%), Positives = 250/573 (43%), Gaps = 99/573 (17%)

Query: 851  EDINECESNP--CVNGACRNNLGSFNCECSPGSKLSSTGLICIDS--------------- 893
            +D +EC   P       C N +GS++C C PG  L   G  C                  
Sbjct: 603  DDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 894  ------LKGTCWLNI-QDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLA 946
                     T  L + Q + C+ N  G     + C+T+G +    C         P    
Sbjct: 663  SEFSQVASNTIPLPLPQPNTCKDN--GPC--KQVCSTVGGSAICSC--------FPGYAI 710

Query: 947  RIKGVTCEDVNECEVFPGVCPNGR-CVNSKGSFHCE-----CPEGLTLDGTGRVCLDIRM 1000
               GV+CED +EC +    C   + CVN+ GSF+C      C +G  L+   R C+DI  
Sbjct: 711  MADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILN-AHRKCVDI-- 767

Query: 1001 EQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFAN 1060
                     +EC+  +    R + C   +G+    +   C +PG    +  C        
Sbjct: 768  ---------NECVTDLHTCSRGEHCVNTLGSFHCYKALTC-EPGYALKDGEC-------- 809

Query: 1061 RGDVLTGRPFYKDINECKAFPGMCTYG-KCRNTIGSFKC----RCNSGFALDMEERNCTD 1115
                       +D++EC      C  G  C+NT GSF C    RC  GF  D  E NC D
Sbjct: 810  -----------EDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQD-PEGNCVD 857

Query: 1116 IDECRISPDLCGSGI-CVNTPGSFECE-----CFEGYESGFMMMKNCMDIDECERNPLLC 1169
            I+EC    + C  G  C+NT GS+ C+     C  GY +     K C+D++ECE     C
Sbjct: 858  INECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTK-CVDVNECETGVHRC 916

Query: 1170 -RGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCN 1228
              G  C N  GS++CDC  G +       C+D+NEC  S        C N +G+Y+CSC 
Sbjct: 917  GEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCA 976

Query: 1229 PGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECE 1288
             G+    D + C D++EC      C  +C N  GSY+C C +GY L  DG +C DIDEC 
Sbjct: 977  SGFLLAADGKRCEDVNECEAQR--CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECA 1034

Query: 1289 NNPDICDGGQCTNIPGEYRCLCYD-GFMASMDMKTCIDVNECDLNSNICMFGE-CENTKG 1346
                I    +C N+PG Y+C C + G+  + + ++C DV+EC L ++ C   E C N +G
Sbjct: 1035 QGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQG 1094

Query: 1347 SFIC---HCQLGY----SVKKGTTGCTDVDECE 1372
            SF C    C   Y      K   T C D  EC+
Sbjct: 1095 SFRCLRFECPPNYVQVSKTKCERTTCHDFLECQ 1127



 Score =  237 bits (604), Expect = 1e-61
 Identities = 169/484 (34%), Positives = 224/484 (46%), Gaps = 62/484 (12%)

Query: 2338 DENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNR-----QGLCFAEVLQ 2392
            D++EC   PG      C+N +GSY C C  GF     G  C         +      +  
Sbjct: 604  DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663

Query: 2393 TICQMASSSRNL-VTKSECCCDGGRGWGHQC-ELCPLPGTAQYKKICPHGPGYT--TDG- 2447
               Q+AS++  L + +   C D G      C ++C   G +    IC   PGY    DG 
Sbjct: 664  EFSQVASNTIPLPLPQPNTCKDNG-----PCKQVCSTVGGSA---ICSCFPGYAIMADGV 715

Query: 2448 --RDIDECKVMPNLCTNGQ-CINTMGSFRC-----FCKVGYTTDISGTSCIDLDECSQSP 2499
               D DEC +  + C+  Q C+NT+GSF C      C  GY  + +   C+D++EC    
Sbjct: 716  SCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILN-AHRKCVDINECVTDL 774

Query: 2500 KPCNY--ICKNTEGSYQC----SCPRGYVLQEDGKTCKDLDECQTKQHNCQ--FLCVNTL 2551
              C+    C NT GS+ C    +C  GY L+ DG+ C+D+DEC    H CQ  FLC NT 
Sbjct: 775  HTCSRGEHCVNTLGSFHCYKALTCEPGYALK-DGE-CEDVDECAMGTHTCQPGFLCQNTK 832

Query: 2552 GGFTC----KCPPGFTQHHTA-CIDNNECGSQPSLCGAKGICQNTPGSFSCE-----CQR 2601
            G F C    +C  GF Q     C+D NEC S    C     C NT GS++C+     C R
Sbjct: 833  GSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICAR 892

Query: 2602 GFSLDATGLNCEDVDECD-GNHRCQHG--CQNILGGYRCGCPQGYIQHYQWNQCVDENEC 2658
            G+     G  C DV+EC+ G HRC  G  C N+ G YRC C  G+ +      C+D NEC
Sbjct: 893  GYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNEC 952

Query: 2659 -SNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGY 2717
             ++P      +C NTLGSY+C+C SGF        C DVNEC + +  C+  C+N  G Y
Sbjct: 953  WASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR--CSQECANIYGSY 1010

Query: 2718 LCGCPPGYYRVGQGH-------CVSGMGFNKGQYLSLDTEVDEENALSPEACYECKINGY 2770
             C C  GY     GH       C  G G     +  L+     + A  PE  Y    NG 
Sbjct: 1011 QCYCRQGYQLAEDGHTCTDIDECAQGAGI-LCTFRCLNVPGSYQCA-CPEQGYTMTANGR 1068

Query: 2771 SKKD 2774
            S KD
Sbjct: 1069 SCKD 1072



 Score =  236 bits (603), Expect = 2e-61
 Identities = 195/668 (29%), Positives = 268/668 (40%), Gaps = 141/668 (21%)

Query: 1806 AVDIDECKEIP------GICANG---VCINQIGSFRCECPTGFSYNDLLLVCEDIDECSN 1856
            A+D DEC EIP       +C       C++ +    C      +        ED D C  
Sbjct: 453  AIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAEDNDSC-- 510

Query: 1857 GDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQ 1916
            G +L ++  DC          C  G ++   G   + N  L  P  C+H +    +G   
Sbjct: 511  GISLYKQCCDC----------CGLGLRVRAEGQSCESNPNLGYP--CNHVMLSCCEGEEP 558

Query: 1917 CICHNGFKASQDQTMCMDVDECE---RHPCGNGT-------------------------- 1947
             I     +  +       V E E   R     GT                          
Sbjct: 559  LIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQH 618

Query: 1948 -CKNTVGSYNCLCYPGFELTHNN------------DCLDIDECSSFFGQV---------- 1984
             C NTVGSY+C C+PGF L  +             +        S F QV          
Sbjct: 619  LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLP 678

Query: 1985 ----CR-NGRCFNEI----GSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGT-CQN 2034
                C+ NG C        GS  C C  GY +  DG +C D +EC+     CS    C N
Sbjct: 679  QPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVN 738

Query: 2035 LEGSFRCI-----CPPGYEVKS-ENCIDINECDEDPNICLFGS-CTNTPGGFQC----LC 2083
              GSF C+     C  GY + +   C+DINEC  D + C  G  C NT G F C     C
Sbjct: 739  TLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTC 798

Query: 2084 PPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELC 2143
             PG+ L D    C D             +C++    +T +    C    G  +   C+  
Sbjct: 799  EPGYALKDG--ECEDV-----------DECAM--GTHTCQPGFLCQNTKGSFY---CQAR 840

Query: 2144 PKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNG-QCINTDGSFRCE----- 2197
             +  +   QD  P G+           D+NEC      C  G  CINT GS+ C+     
Sbjct: 841  QRCMDGFLQD--PEGNCV---------DINECTSLSEPCRPGFSCINTVGSYTCQRNPLI 889

Query: 2198 CPMGYNLDYTGVRCVDTDECSIG-NPCGNG-TCTNVIGSFECNCNEGFEPGPM-MNCEDI 2254
            C  GY+    G +CVD +EC  G + CG G  C N+ GS+ C+C  GF+       C D+
Sbjct: 890  CARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDV 949

Query: 2255 NECAQNP-LLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCK 2313
            NEC  +P  LC   C NT GSY C+C  G+ L  D K C+D++EC     + +     C 
Sbjct: 950  NECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNEC-----EAQRCSQECA 1004

Query: 2314 NLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNE-GFQSS 2372
            N+ G++ C C  G     DG  C D +EC    GI    RC+N+ GSY+C C E G+  +
Sbjct: 1005 NIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMT 1064

Query: 2373 SSGTECLD 2380
            ++G  C D
Sbjct: 1065 ANGRSCKD 1072



 Score =  231 bits (589), Expect = 8e-60
 Identities = 214/776 (27%), Positives = 308/776 (39%), Gaps = 159/776 (20%)

Query: 593  NTDGSFQCICNAGFELTTDGKNCVDHDEC-TTTNMCLNGM---CINEDGSFKCICKPGFV 648
            +T    +  C AG +   D   C++  E  T  N+C       C++      C+   G +
Sbjct: 437  STKDLIETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMA--GVL 494

Query: 649  LAPNGRYC--TDVDECQTPGICMNGHCINSEGSFRCDCPP-GLAVGMDGRVCVDTHMRST 705
             A  G  C   D D C   GI +   C        CDC   GL V  +G+ C        
Sbjct: 495  GAKEGETCGAEDNDSC---GISLYKQC--------CDCCGLGLRVRAEGQSCESNPNLGY 543

Query: 706  CYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAK---NSAEFHGLCSSGVGI 762
                +    C    P  V +              P +P  A    + AE  G  +  +G 
Sbjct: 544  PCNHVMLSCCEGEEPLIVPEVR-----------RPPEPAAAPRRVSEAEMAGREALSLGT 592

Query: 763  TVD------GRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNC-------- 808
              +      G D +EC L P      +C N  GSY C C  G+     GR C        
Sbjct: 593  EAELPNSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQ 652

Query: 809  ----------IDIDECLVNRL--------LC-DNG----LCRNTPGSYSCTCPPGYVFRT 845
                       +  +   N +         C DNG    +C    GS  C+C PGY    
Sbjct: 653  PEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMA 712

Query: 846  ETETCEDINEC--ESNPCVNGA-CRNNLGSFNCE-----CSPGSKLSSTGLICIDSLKGT 897
            +  +CED +EC   ++ C     C N LGSF C      C+ G  L++    C+D     
Sbjct: 713  DGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRK-CVDI---- 767

Query: 898  CWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVN 957
                   + C  +++  +    C  TLG+        C     C  G A +K   CEDV+
Sbjct: 768  -------NECVTDLHTCSRGEHCVNTLGSF------HCYKALTCEPGYA-LKDGECEDVD 813

Query: 958  ECEVFPGVC-PNGRCVNSKGSFHCE----CPEGLTLDGTGRVCLDIRMEQCYLKWDEDEC 1012
            EC +    C P   C N+KGSF+C+    C +G   D  G  C+DI           +EC
Sbjct: 814  ECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN-CVDI-----------NEC 861

Query: 1013 I---HPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRP 1069
                 P    F   +C   VG+     C+  P         +C RG   ++ G       
Sbjct: 862  TSLSEPCRPGF---SCINTVGS---YTCQRNP--------LICARGYHASDDGTKCV--- 904

Query: 1070 FYKDINECKAFPGMCTYGK-CRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGS 1128
               D+NEC+     C  G+ C N  GS++C C +GF  D   R C D++EC  SP     
Sbjct: 905  ---DVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQ 961

Query: 1129 GICVNTPGSFECECFEGYESGFMMM---KNCMDIDECERNPLLCRGGTCVNTEGSFQCDC 1185
              C NT GS+ C C     SGF++    K C D++ECE          C N  GS+QC C
Sbjct: 962  HTCENTLGSYRCSC----ASGFLLAADGKRCEDVNECEAQRC---SQECANIYGSYQCYC 1014

Query: 1186 PLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSC-NPGYQATPDRQGCTDID 1244
              G++L+     C DI+EC+    +    +C+N+ G+YQC+C   GY  T + + C D+D
Sbjct: 1015 RQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVD 1074

Query: 1245 ECMIMNGGCD--TQCTNSEGSYEC---SCSEGYALMP----DGRSCADIDECENNP 1291
            EC +    C     C N +GS+ C    C   Y  +     +  +C D  EC+N+P
Sbjct: 1075 ECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSP 1130



 Score =  203 bits (516), Expect = 2e-51
 Identities = 153/467 (32%), Positives = 211/467 (45%), Gaps = 79/467 (16%)

Query: 471  VGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGR-CIPTVSSYRCE-----CNMG 524
            VGG+ + +   G  I    +  +  D C   A+ C   + C+ T+ S+ C      C  G
Sbjct: 696  VGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADG 755

Query: 525  YKQDANGDCIDVDECTSN--PCTNGD-CVNTPGSYYC----KCHAGFQRTPTKQACIDID 577
            Y  +A+  C+D++EC ++   C+ G+ CVNT GS++C     C  G+     +  C D+D
Sbjct: 756  YILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE--CEDVD 813

Query: 578  ECIQNGVLCKNG-RCVNTDGSFQCI----CNAGFELTTDGKNCVDHDECTT-TNMCLNGM 631
            EC      C+ G  C NT GSF C     C  GF    +G NCVD +ECT+ +  C  G 
Sbjct: 814  ECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGF 872

Query: 632  -CINEDGSFKC-----ICKPGFVLAPNGRYCTDVDECQTPGI--CMNGH-CINSEGSFRC 682
             CIN  GS+ C     IC  G+  + +G  C DV+EC+T G+  C  G  C N  GS+RC
Sbjct: 873  SCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECET-GVHRCGEGQVCHNLPGSYRC 931

Query: 683  DCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQ 742
            DC  G      GR C+D +                           C A+P    G  CQ
Sbjct: 932  DCKAGFQRDAFGRGCIDVNE--------------------------CWASP----GRLCQ 961

Query: 743  PCPAKNSAEFHGLCSSGVGITVDGR---DINECALDPDICANGICENLRGSYRCNCNSGY 799
                     +   C+SG  +  DG+   D+NEC  +   C+   C N+ GSY+C C  GY
Sbjct: 962  HTCENTLGSYRCSCASGFLLAADGKRCEDVNEC--EAQRCSQE-CANIYGSYQCYCRQGY 1018

Query: 800  EPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCP-PGYVFRTETETCEDINECE- 857
            +    G  C DIDEC     +     C N PGSY C CP  GY       +C+D++EC  
Sbjct: 1019 QLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECAL 1078

Query: 858  -SNPCVNG-ACRNNLGSFNC---ECSPG----SKLSSTGLICIDSLK 895
             ++ C     C N  GSF C   EC P     SK       C D L+
Sbjct: 1079 GTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLE 1125



 Score =  201 bits (511), Expect = 9e-51
 Identities = 167/556 (30%), Positives = 217/556 (39%), Gaps = 133/556 (23%)

Query: 496  DICKHHANLCLNGRCIPTVSSYRCECNMGYK-QDANGDC--------------------- 533
            ++C+H   LC+N     TV SY C C  G+  QD    C                     
Sbjct: 614  ELCQH---LCIN-----TVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEF 665

Query: 534  ------------IDVDECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQ 581
                           + C  N      C    GS  C C  G+       +C D DEC+ 
Sbjct: 666  SQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLM 725

Query: 582  NGVLCKNGR-CVNTDGSFQCI-----CNAGFELTTDGKNCVDHDECTT-TNMCLNG-MCI 633
                C   + CVNT GSF C+     C  G+ L    K CVD +EC T  + C  G  C+
Sbjct: 726  GAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRK-CVDINECVTDLHTCSRGEHCV 784

Query: 634  NEDGSFKC----ICKPGFVLAPNGRYCTDVDEC-QTPGICMNGH-CINSEGSFRCD---- 683
            N  GSF C     C+PG+ L      C DVDEC      C  G  C N++GSF C     
Sbjct: 785  NTLGSFHCYKALTCEPGYALKDG--ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQR 842

Query: 684  CPPGLAVGMDGRVCVD----THMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGE 739
            C  G     +G  CVD    T +   C  G     C+         S  C  NP      
Sbjct: 843  CMDGFLQDPEGN-CVDINECTSLSEPCRPGFS---CIN-----TVGSYTCQRNP------ 887

Query: 740  PCQPCPAKNSAEFHGLCSSGVGITVDGR---DINECALDPDICANG-ICENLRGSYRCNC 795
                           +C+ G   + DG    D+NEC      C  G +C NL GSYRC+C
Sbjct: 888  --------------LICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDC 933

Query: 796  NSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINE 855
             +G++ DA GR CID++EC  +        C NT GSY C+C  G++   + + CED+NE
Sbjct: 934  KAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNE 993

Query: 856  CESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGAT 915
            CE+  C +  C N  GS+ C C  G +L+  G  C D                       
Sbjct: 994  CEAQRC-SQECANIYGSYQCYCRQGYQLAEDGHTCTDI---------------------- 1030

Query: 916  LKSECCATLGAAWGSPCERC--ELDTACPRG--LARIKGVTCEDVNECEVFPGVCPNGR- 970
               EC    G      C         ACP         G +C+DV+EC +    C     
Sbjct: 1031 --DECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAET 1088

Query: 971  CVNSKGSFHC---ECP 983
            C N +GSF C   ECP
Sbjct: 1089 CHNIQGSFRCLRFECP 1104



 Score =  191 bits (485), Expect = 9e-48
 Identities = 196/777 (25%), Positives = 289/777 (37%), Gaps = 154/777 (19%)

Query: 1176 NTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGK---CVNMIGTYQCSCNPGYQ 1232
            +T+   +  C  G + +   ++C++I E    DN+CR  +   CV+ +    C       
Sbjct: 437  STKDLIETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGA 496

Query: 1233 ATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPD 1292
               +  G  D D C I       QC +        C  G  +  +G+SC      E+NP+
Sbjct: 497  KEGETCGAEDNDSCGI---SLYKQCCDC-------CGLGLRVRAEGQSC------ESNPN 540

Query: 1293 I-----------CDGGQCTNIPGEYRC--------LCYDGFMASMDMKTC---------- 1323
            +           C+G +   +P   R            +  MA  +  +           
Sbjct: 541  LGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSL 600

Query: 1324 --IDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMH 1381
               D +EC L         C NT GS+ C C  G+S++     C             + H
Sbjct: 601  PGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRP-----------EGH 649

Query: 1382 ASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT 1441
                  P           + +    + L + +           C    GS  C+C  G+ 
Sbjct: 650  PPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYA 709

Query: 1442 --GDGFTCSDVDECAENINLCENGQ-CLNVPGAYRCE-----CEMGFTPASDSRSCQDID 1493
               DG +C D DEC    + C   Q C+N  G++ C      C  G+   +  R C DI+
Sbjct: 710  IMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYI-LNAHRKCVDIN 768

Query: 1494 ECSFQ-NICVFGT-CNNLPGMFHCI----CDDGYELDRTGGNCTDIDECADPIN-CVNG- 1545
            EC    + C  G  C N  G FHC     C+ GY L    G C D+DECA   + C  G 
Sbjct: 769  ECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALK--DGECEDVDECAMGTHTCQPGF 826

Query: 1546 LCVNTPGRYECN----CPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGV 1601
            LC NT G + C     C   F  +P G  CVD  +  C     P   G    NT      
Sbjct: 827  LCQNTKGSFYCQARQRCMDGFLQDPEG-NCVD--INECTSLSEPCRPGFSCINTVGSYTC 883

Query: 1602 SRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLC 1661
             R+   C+ G             ++++  T C                D++EC+     C
Sbjct: 884  QRNPLICARG------------YHASDDGTKCV---------------DVNECETGVHRC 916

Query: 1662 -QGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICP 1720
             +G  C N  GS++C+C  G+      R C D++EC+A PG     TC NTLG+Y C C 
Sbjct: 917  GEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCA 976

Query: 1721 PEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCP 1780
              ++    G  C D+ +    R      C  E         C   Y              
Sbjct: 977  SGFLLAADGKRCEDVNECEAQR------CSQE---------CANIY-------------- 1007

Query: 1781 TPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECP-TGF 1839
                  ++  C        D HT    DIDEC +  GI     C+N  GS++C CP  G+
Sbjct: 1008 ----GSYQCYCRQGYQLAEDGHT--CTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGY 1061

Query: 1840 SYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNEC 1896
            +       C+D+DEC+ G + C     C N  GS+RC     F+  PN   V + +C
Sbjct: 1062 TMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRC---LRFECPPNYVQVSKTKC 1115



 Score =  187 bits (474), Expect = 2e-46
 Identities = 158/532 (29%), Positives = 210/532 (39%), Gaps = 115/532 (21%)

Query: 2276 ECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI-------CPPGMA 2328
            E  C  G     D   C ++ E     + C +    C        C+       C  G+ 
Sbjct: 443  ETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHC--------CVSYLQEKSCMAGVL 494

Query: 2329 RRPDGEGC--VDENECRTKPGICENGRCVNIIG--------SYRCECNE--GFQSSSSGT 2376
               +GE C   D + C    GI    +C +  G           CE N   G+  +    
Sbjct: 495  GAKEGETCGAEDNDSC----GISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVML 550

Query: 2377 ECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKI 2436
             C +  + L   EV +     A+  R  V+++E         G + EL            
Sbjct: 551  SCCEGEEPLIVPEVRRPPEPAAAPRR--VSEAEMAGREALSLGTEAEL------------ 596

Query: 2437 CPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSC-----ID 2491
             P+    +  G D DEC ++P       CINT+GS+ C C  G++    G +C       
Sbjct: 597  -PN----SLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPP 651

Query: 2492 LDECSQSPK---------------------------PCNYICKNTEGSYQCSCPRGYVLQ 2524
              E  Q P                            PC  +C    GS  CSC  GY + 
Sbjct: 652  QPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIM 711

Query: 2525 EDGKTCKDLDECQTKQHNC--QFLCVNTLGGFTC-----KCPPGFTQH-HTACIDNNECG 2576
             DG +C+D DEC    H+C  +  CVNTLG F C      C  G+  + H  C+D NEC 
Sbjct: 712  ADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECV 771

Query: 2577 SQPSLCGAKGICQNTPGSFSC----ECQRGFSLDATGLNCEDVDECD-GNHRCQHG--CQ 2629
            +    C     C NT GSF C     C+ G++L      CEDVDEC  G H CQ G  CQ
Sbjct: 772  TDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDG--ECEDVDECAMGTHTCQPGFLCQ 829

Query: 2630 NILGGYRC----GCPQGYIQHYQWNQCVDENEC---SNPNACGSASCYNTLGSYKC---- 2678
            N  G + C     C  G++Q  + N CVD NEC   S P   G  SC NT+GSY C    
Sbjct: 830  NTKGSFYCQARQRCMDGFLQDPEGN-CVDINECTSLSEPCRPG-FSCINTVGSYTCQRNP 887

Query: 2679 -ACPSGFSFDQFSSACHDVNECSSSKNPCNYG--CSNTEGGYLCGCPPGYYR 2727
              C  G+      + C DVNEC +  + C  G  C N  G Y C C  G+ R
Sbjct: 888  LICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQR 939



 Score =  160 bits (404), Expect = 2e-38
 Identities = 150/520 (28%), Positives = 198/520 (38%), Gaps = 109/520 (20%)

Query: 266  IPNIRTGACQDVDECQAIPG-ICQGGNCINTVGSFECRC--------------PAGH-KQ 309
            +PN   G   D DEC  +PG +CQ   CINTVGS+ C C              P GH  Q
Sbjct: 596  LPNSLPG--DDQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQ 652

Query: 310  SETTQKCEDIDECSII-----------PGICETG-----ECSNTVGSYFCVCPRGYVTST 353
             E  Q+     E S +           P  C+        CS   GS  C C  GY    
Sbjct: 653  PEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMA 712

Query: 354  DGSRCIDQ---------------------------RTGMCFSGLVNG--RCAQELPGRMT 384
            DG  C DQ                            T +C  G +    R   ++   +T
Sbjct: 713  DGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVT 772

Query: 385  KMQCC--------------------CEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMG 424
             +  C                    CEPG     G   E   V         C  G    
Sbjct: 773  DLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDG---ECEDVDECAMGTHTCQPGFLCQ 829

Query: 425  GIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPI 484
               GS   +      +GF     GN         +  P   GFS  +   G     + P+
Sbjct: 830  NTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFS-CINTVGSYTCQRNPL 888

Query: 485  ITGLTIL-----NQTIDI--CKHHANLCLNGR-CIPTVSSYRCECNMGYKQDANG-DCID 535
            I            + +D+  C+   + C  G+ C     SYRC+C  G+++DA G  CID
Sbjct: 889  ICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCID 948

Query: 536  VDECTSNP--CTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVN 593
            V+EC ++P       C NT GSY C C +GF      + C D++EC      C    C N
Sbjct: 949  VNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNEC--EAQRCSQ-ECAN 1005

Query: 594  TDGSFQCICNAGFELTTDGKNCVDHDECTT-TNMCLNGMCINEDGSFKCIC-KPGFVLAP 651
              GS+QC C  G++L  DG  C D DEC     +     C+N  GS++C C + G+ +  
Sbjct: 1006 IYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTA 1065

Query: 652  NGRYCTDVDECQ--TPGICMNGHCINSEGSFRC---DCPP 686
            NGR C DVDEC   T        C N +GSFRC   +CPP
Sbjct: 1066 NGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPP 1105



 Score = 99.0 bits (245), Expect = 6e-20
 Identities = 103/378 (27%), Positives = 147/378 (38%), Gaps = 55/378 (14%)

Query: 33   PPPKPPRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLRGPNVCGSR 92
            P P   +   P +QV S   GS      P Y    A +A  V    Q + L G + C  R
Sbjct: 678  PQPNTCKDNGPCKQVCSTVGGSAICSCFPGY----AIMADGVSCEDQDECLMGAHDCSRR 733

Query: 93   FHSYCCPGWKTLPGGNQCIVPICRNSCGDGF-------CSRPNMC-----TCSSGQ-ISS 139
               +C     +    N  ++      C DG+       C   N C     TCS G+   +
Sbjct: 734  --QFCVNTLGSFYCVNHTVL------CADGYILNAHRKCVDINECVTDLHTCSRGEHCVN 785

Query: 140  TCGSKSIQQCSVRCMNGGTCADDHCQ-CQKGYIGTYCGQP--VCENGCQNGGRCIGPNRC 196
            T GS    + ++ C  G    D  C+   +  +GT+  QP  +C+N     G      R 
Sbjct: 786  TLGSFHCYK-ALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQN---TKGSFYCQARQ 841

Query: 197  ACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPA 256
             C+ GF             C +   ++ C+    G  C  T+   T           C  
Sbjct: 842  RCMDGFLQDPEGNCVDINECTSL--SEPCR---PGFSCINTVGSYT-----------CQR 885

Query: 257  QPQPCRRGFIPNIRTGACQDVDECQAIPGIC-QGGNCINTVGSFECRCPAGHKQSETTQK 315
             P  C RG+  +     C DV+EC+     C +G  C N  GS+ C C AG ++    + 
Sbjct: 886  NPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRG 945

Query: 316  CEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRC 375
            C D++EC   PG      C NT+GSY C C  G++ + DG RC D     C +     RC
Sbjct: 946  CIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCED--VNECEA----QRC 999

Query: 376  AQELPGRMTKMQCCCEPG 393
            +QE        QC C  G
Sbjct: 1000 SQECANIYGSYQCYCRQG 1017



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 91/295 (30%), Positives = 116/295 (39%), Gaps = 60/295 (20%)

Query: 89   CGSRFHSYCCPGW--KTLPGGNQCIVPICRNSCGDGFCSRP-------NMCT-----CSS 134
            C    H+ C PG+  +   G   C     R  C DGF   P       N CT     C  
Sbjct: 815  CAMGTHT-CQPGFLCQNTKGSFYCQA---RQRCMDGFLQDPEGNCVDINECTSLSEPCRP 870

Query: 135  G-QISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENG---CQNGGRC 190
            G    +T GS + Q+  + C  G   +DD  +C             CE G   C  G  C
Sbjct: 871  GFSCINTVGSYTCQRNPLICARGYHASDDGTKC--------VDVNECETGVHRCGEGQVC 922

Query: 191  I---GPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAW 247
                G  RC C  GF     +RD     C   VN                 C A+ GR  
Sbjct: 923  HNLPGSYRCDCKAGF-----QRDAFGRGCI-DVNE----------------CWASPGRLC 960

Query: 248  GHPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAG 306
             H CE      +  C  GF+       C+DV+EC+A    C    C N  GS++C C  G
Sbjct: 961  QHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR--CSQ-ECANIYGSYQCYCRQG 1017

Query: 307  HKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCP-RGYVTSTDGSRCID 360
            ++ +E    C DIDEC+   GI  T  C N  GSY C CP +GY  + +G  C D
Sbjct: 1018 YQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD 1072


>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
          Length = 937

 Score =  276 bits (705), Expect = 3e-73
 Identities = 147/413 (35%), Positives = 210/413 (50%), Gaps = 21/413 (5%)

Query: 1089 CRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGY-- 1146
            C N  GS+ CRC  G+ L+ ++  C   D C +    C   +CVN PGSF C+C+ GY  
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311

Query: 1147 -ESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECS 1205
             E G    K C+ +D C      C    CVN +GS+ C C  G  L+P ++ C  I+ C+
Sbjct: 312  AEDG----KRCVAVDYCASENHGCE-HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCA 366

Query: 1206 LSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYE 1265
             S++ C++ +CVN   +Y C C  G+   PD++ C  I+ C +   GC+ +C N E SY 
Sbjct: 367  SSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425

Query: 1266 CSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCID 1325
            C C  GY L P+G++C+ +D C      C+   C N    + C C +GF+ + D+KTC  
Sbjct: 426  CRCHRGYTLDPNGKTCSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSR 484

Query: 1326 VNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCL 1385
            V+ C L+ + C +  C N   SF C C  G+ ++     C  +D C +G H C+   SC+
Sbjct: 485  VDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE--HSCV 541

Query: 1386 NIPGSFKCSCREGWI--GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF--T 1441
            +   SF C C EG+I   +G  C   D C    H C     CVN+  SY C C EGF   
Sbjct: 542  SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC--EHICVNSDDSYTCECLEGFRLA 599

Query: 1442 GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDE 1494
             DG  C   D C    + CE+  C+N   +Y C+C  GF  A D R C+   E
Sbjct: 600  EDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651



 Score =  259 bits (662), Expect = 3e-68
 Identities = 143/417 (34%), Positives = 205/417 (49%), Gaps = 16/417 (3%)

Query: 1131 CVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1190
            C+N PGS+ C C +GY         C   D C      C    CVN  GSF C C  G+ 
Sbjct: 253  CINIPGSYVCRCKQGYILN-SDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYA 310

Query: 1191 LSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMN 1250
            L+   + CV ++ C+  ++ C + +CVN  G+Y C C+ G+   PD++ CT ID C   N
Sbjct: 311  LAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369

Query: 1251 GGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLC 1310
             GC  +C N++ SY C C +G+ L PD ++C  I+ C  N   C+  +C N+   Y C C
Sbjct: 370  HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE-HECVNMEESYYCRC 428

Query: 1311 YDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDE 1370
            + G+    + KTC  V+ C    + C    C NT+ SF+C C  G+ + +    C+ VD 
Sbjct: 429  HRGYTLDPNGKTCSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487

Query: 1371 CEIGAHNCDMHASCLNIPGSFKCSCREGWI--GNGIKCIDLDECSNGTHQCSINAQCVNT 1428
            C +  H C+   SC+N+  SF C C EG +   +G  C  LD C+ G H C     CV++
Sbjct: 488  CLLSDHGCEY--SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVSS 543

Query: 1429 PGSYRCACSEGF--TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDS 1486
              S+ C C EG+    DG TC   D C    + CE+  C+N   +Y CEC  GF  A D 
Sbjct: 544  EDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDG 602

Query: 1487 RSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCV 1543
            + C+  D C   +      C N    + C C +G+ L   G  C    E   PI+ V
Sbjct: 603  KRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE--GPIDLV 657



 Score =  253 bits (645), Expect = 3e-66
 Identities = 142/422 (33%), Positives = 199/422 (47%), Gaps = 12/422 (2%)

Query: 1174 CVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQA 1233
            C+N  GS+ C C  G+ L+  +  C   + C++ D+ C    CVN+ G++ C C  GY  
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311

Query: 1234 TPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDI 1293
              D + C  +D C   N GC+ +C N++GSY C C EG+AL PD ++C  ID C ++   
Sbjct: 312  AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371

Query: 1294 CDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQ 1353
            C   +C N    Y C C  GF  + D KTC  +N C LN   C   EC N + S+ C C 
Sbjct: 372  CQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCH 429

Query: 1354 LGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGN-GIK-CIDLDE 1411
             GY++      C+ VD C    H C+    CLN   SF C C EG++ N  +K C  +D 
Sbjct: 430  RGYTLDPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487

Query: 1412 CSNGTHQCSINAQCVNTPGSYRCACSEGFT--GDGFTCSDVDECAENINLCENGQCLNVP 1469
            C    H C  +  CVN   S+ C C EG     DG TC+ +D CA   + CE+  C++  
Sbjct: 488  CLLSDHGCEYS--CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSE 544

Query: 1470 GAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGN 1529
             ++ C+C  G+    D ++C+  D C   +      C N    + C C +G+ L   G  
Sbjct: 545  DSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKR 604

Query: 1530 CTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDG 1589
            C   D C    +    +CVN    Y C C   F L   G  C     G   L F   G  
Sbjct: 605  CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSK 664

Query: 1590 SL 1591
            SL
Sbjct: 665  SL 666



 Score =  234 bits (598), Expect = 7e-61
 Identities = 139/443 (31%), Positives = 191/443 (43%), Gaps = 48/443 (10%)

Query: 2264 CAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCIC 2323
            CA  C+N  GSY C C  GY L  DQ  C+  D CA   H+CE    +C N+ G+F+C C
Sbjct: 249  CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ---LCVNVPGSFVCQC 305

Query: 2324 PPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQ 2383
              G A   DG+ CV  + C ++   CE+  CVN  GSY C+C+EGF  +     C     
Sbjct: 306  YSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC----- 359

Query: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGY 2443
                                  TK + C     G  H+C    +     Y   C  G   
Sbjct: 360  ----------------------TKIDYCASSNHGCQHEC----VNTDDSYSCHCLKGFTL 393

Query: 2444 TTDG---RDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPK 2500
              D    R I+ C +    C + +C+N   S+ C C  GYT D +G +C  +D C+Q   
Sbjct: 394  NPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDH 452

Query: 2501 PCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPP 2560
             C  +C NTE S+ C C  G+++ ED KTC  +D C    H C++ CVN    F C+CP 
Sbjct: 453  GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE 512

Query: 2561 GFTQHHTACIDNNECGSQPSLC----GAKGICQNTPGSFSCECQRGFSLDATGLNCEDVD 2616
            G    H    D   C    S      G +  C ++  SF C+C  G+ L   G  C   D
Sbjct: 513  G----HVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKD 568

Query: 2617 ECDG-NHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGS 2675
             C   +H C+H C N    Y C C +G+       +C  ++ C + +      C N   S
Sbjct: 569  VCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNS 628

Query: 2676 YKCACPSGFSFDQFSSACHDVNE 2698
            Y C C  GF   +    C    E
Sbjct: 629  YICKCSEGFVLAEDGRRCKKCTE 651



 Score =  211 bits (538), Expect = 6e-54
 Identities = 135/460 (29%), Positives = 197/460 (42%), Gaps = 60/460 (13%)

Query: 1246 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGE 1305
            C  +   C   C N  GSY C C +GY L  D  +C   D C      C+   C N+PG 
Sbjct: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE-QLCVNVPGS 300

Query: 1306 YRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGC 1365
            + C CY G+  + D K C+ V+ C   ++ C   EC N  GS++C C  G+++      C
Sbjct: 301  FVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC 359

Query: 1366 TDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIK--CIDLDECSNGTHQCSINA 1423
            T +D C    H C     C+N   S+ C C +G+  N  K  C  ++ C+     C    
Sbjct: 360  TKIDYCASSNHGC--QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC--EH 415

Query: 1424 QCVNTPGSYRCACSEGFTGD--GFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFT 1481
            +CVN   SY C C  G+T D  G TCS VD CA+  + CE   CLN   ++ C+C  GF 
Sbjct: 416  ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFL 474

Query: 1482 PASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPIN 1541
               D ++C  +D C   +     +C N+   F C C +G+ L   G  C  +D CA   +
Sbjct: 475  INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534

Query: 1542 CVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGV 1601
                 CV++   + C C   + L   G  C                              
Sbjct: 535  GCEHSCVSSEDSFVCQCFEGYILREDGKTC------------------------------ 564

Query: 1602 SRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLC 1661
             R   C ++     + C     VNS + YT C   EGFR      + ED   C+    +C
Sbjct: 565  RRKDVCQAIDHGCEHIC-----VNSDDSYT-CECLEGFR------LAEDGKRCRR-KDVC 611

Query: 1662 QGGN------CINTFGSFQCECPQGYYLSEDTRICEDIDE 1695
            +  +      C+N   S+ C+C +G+ L+ED R C+   E
Sbjct: 612  KSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651



 Score =  207 bits (528), Expect = 9e-53
 Identities = 119/380 (31%), Positives = 167/380 (43%), Gaps = 40/380 (10%)

Query: 2187 CINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPG 2246
            C+N  GSF C+C  GY L   G RCV  D C+  N      C N  GS+ C C+EGF   
Sbjct: 294  CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353

Query: 2247 P-MMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDC 2305
            P    C  I+ CA +   C   C+NT  SY C C  G+ L  D+K C+ ++ CA     C
Sbjct: 354  PDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413

Query: 2306 ESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCEC 2365
            E     C N+  ++ C C  G    P+G+ C   + C  +   CE   C+N   S+ C+C
Sbjct: 414  EHE---CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQC 469

Query: 2366 NEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELC 2425
            +EGF  +     C  +R   C                                 H CE  
Sbjct: 470  SEGFLINEDLKTC--SRVDYCLLS-----------------------------DHGCEYS 498

Query: 2426 PLPGTAQYKKICPHGPGYTTDGR---DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTT 2482
             +     +   CP G    +DG+    +D C +  + C +  C+++  SF C C  GY  
Sbjct: 499  CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYIL 557

Query: 2483 DISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHN 2542
               G +C   D C      C +IC N++ SY C C  G+ L EDGK C+  D C++  H 
Sbjct: 558  REDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG 617

Query: 2543 CQFLCVNTLGGFTCKCPPGF 2562
            C+ +CVN    + CKC  GF
Sbjct: 618  CEHICVNNGNSYICKCSEGF 637



 Score =  207 bits (527), Expect = 1e-52
 Identities = 138/452 (30%), Positives = 205/452 (45%), Gaps = 55/452 (12%)

Query: 1341 CENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWI 1400
            C N  GS++C C+ GY +    T C   D C +  HNC+    C+N+PGSF C C  G+ 
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVPGSFVCQCYSGYA 310

Query: 1401 --GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT--GDGFTCSDVDECAEN 1456
               +G +C+ +D C++  H C    +CVN  GSY C C EGF    D  TC+ +D CA +
Sbjct: 311  LAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASS 368

Query: 1457 INLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCI 1516
             + C++ +C+N   +Y C C  GFT   D ++C+ I+ C+         C N+   ++C 
Sbjct: 369  NHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCR 427

Query: 1517 CDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRV 1576
            C  GY LD  G  C+ +D CA   +    LC+NT   + C C   F +N     C  +RV
Sbjct: 428  CHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTC--SRV 485

Query: 1577 GNCYLKFGPRGDGSLSCNTEIGVGVSRS-SCCCSLGKAWGNPCETCPPVNSTEYYTLCPG 1635
              C L          SC     V + RS +C C  G    +  +TC  ++S      C  
Sbjct: 486  DYCLLS---DHGCEYSC-----VNMDRSFACQCPEGHVLRSDGKTCAKLDS------CAL 531

Query: 1636 GEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDE 1695
            G+                C+         +C+++  SF C+C +GY L ED + C   D 
Sbjct: 532  GD--------------HGCEH--------SCVSSEDSFVCQCFEGYILREDGKTCRRKDV 569

Query: 1696 CFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPF 1755
            C A    C    C N+  +YTC C   +     G  C   RK  C  +++G  CE+    
Sbjct: 570  CQAIDHGC-EHICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVCKSTHHG--CEHICVN 624

Query: 1756 NVTKRMCCCTYNVGKAWN-KPCEPCPTPGTAD 1786
            N    +C C+     A + + C+ C T G  D
Sbjct: 625  NGNSYICKCSEGFVLAEDGRRCKKC-TEGPID 655



 Score =  207 bits (527), Expect = 1e-52
 Identities = 127/450 (28%), Positives = 203/450 (45%), Gaps = 55/450 (12%)

Query: 971  CVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWD---EDECIHPVPGKFRMDACCC 1027
            C+N  GS+ C C +G  L+     C   R++      D   E  C++ VPG F    C C
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTC---RIQDLCAMEDHNCEQLCVN-VPGSF---VCQC 305

Query: 1028 AVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYG 1087
              G A   + + C                                 ++ C +    C + 
Sbjct: 306  YSGYALAEDGKRCVA-------------------------------VDYCASENHGCEH- 333

Query: 1088 KCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYE 1147
            +C N  GS+ C+C+ GFAL+ +++ CT ID C  S   C    CVNT  S+ C C +G+ 
Sbjct: 334  ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGC-QHECVNTDDSYSCHCLKGFT 392

Query: 1148 SGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLS 1207
                  K C  I+ C  N   C    CVN E S+ C C  G+ L P+ + C  ++ C+  
Sbjct: 393  LN-PDKKTCRRINYCALNKPGCE-HECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQ 450

Query: 1208 DNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECS 1267
            D+ C    C+N   ++ C C+ G+    D + C+ +D C++ + GC+  C N + S+ C 
Sbjct: 451  DHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQ 509

Query: 1268 CSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVN 1327
            C EG+ L  DG++CA +D C      C+   C +    + C C++G++   D KTC   +
Sbjct: 510  CPEGHVLRSDGKTCAKLDSCALGDHGCE-HSCVSSEDSFVCQCFEGYILREDGKTCRRKD 568

Query: 1328 ECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNI 1387
             C    + C    C N+  S+ C C  G+ + +    C   D C+   H C+    C+N 
Sbjct: 569  VCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCE--HICVNN 625

Query: 1388 PGSFKCSCREGWI--GNGIKCIDLDECSNG 1415
              S+ C C EG++   +G +C    +C+ G
Sbjct: 626  GNSYICKCSEGFVLAEDGRRC---KKCTEG 652



 Score =  206 bits (524), Expect = 3e-52
 Identities = 123/443 (27%), Positives = 184/443 (41%), Gaps = 50/443 (11%)

Query: 2298 CAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNI 2357
            C+   H+C      C N+ G+++C C  G     D   C  ++ C  +   CE   CVN+
Sbjct: 242  CSTLEHNCAH---FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNV 297

Query: 2358 IGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRG 2417
             GS+ C+C  G+  +  G  C+                             + C     G
Sbjct: 298  PGSFVCQCYSGYALAEDGKRCV---------------------------AVDYCASENHG 330

Query: 2418 WGHQCELCPLPGTAQYKKICPHGPGYTTDGRD---IDECKVMPNLCTNGQCINTMGSFRC 2474
              H+C    +     Y   C  G     D +    ID C    + C + +C+NT  S+ C
Sbjct: 331  CEHEC----VNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSC 385

Query: 2475 FCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLD 2534
             C  G+T +    +C  ++ C+ +   C + C N E SY C C RGY L  +GKTC  +D
Sbjct: 386  HCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVD 445

Query: 2535 ECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLC-----GAKGICQ 2589
             C  + H C+ LC+NT   F C+C  GF  +     D   C S+   C     G +  C 
Sbjct: 446  HCAQQDHGCEQLCLNTEDSFVCQCSEGFLINE----DLKTC-SRVDYCLLSDHGCEYSCV 500

Query: 2590 NTPGSFSCECQRGFSLDATGLNCEDVDECD-GNHRCQHGCQNILGGYRCGCPQGYIQHYQ 2648
            N   SF+C+C  G  L + G  C  +D C  G+H C+H C +    + C C +GYI    
Sbjct: 501  NMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRED 560

Query: 2649 WNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNY 2708
               C  ++ C   +      C N+  SY C C  GF   +    C   + C S+ + C +
Sbjct: 561  GKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH 620

Query: 2709 GCSNTEGGYLCGCPPGYYRVGQG 2731
             C N    Y+C C  G+     G
Sbjct: 621  ICVNNGNSYICKCSEGFVLAEDG 643



 Score =  190 bits (482), Expect = 2e-47
 Identities = 140/458 (30%), Positives = 204/458 (44%), Gaps = 57/458 (12%)

Query: 1854 CSNGDNLCQRNADCINSPGSYRCECAAGFKL-SPNGACVDRNECLEIPNVCSHGLCVDLQ 1912
            CS  ++ C     CIN PGSY C C  G+ L S    C  ++ C    + C   LCV++ 
Sbjct: 242  CSTLEHNCAHF--CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVP 298

Query: 1913 GSYQCICHNGFKASQDQTMCMDVDEC--ERHPCGNGTCKNTVGSYNCLCYPGFELT-HNN 1969
            GS+ C C++G+  ++D   C+ VD C  E H C +  C N  GSY C C+ GF L     
Sbjct: 299  GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKK 357

Query: 1970 DCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSP 2029
             C  ID C+S     C++  C N   S+ C C +G+ L PD K C   N C      C  
Sbjct: 358  TCTKIDYCAS-SNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE- 414

Query: 2030 GTCQNLEGSFRCICPPGY--EVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGF 2087
              C N+E S+ C C  GY  +   + C  ++ C +  + C    C NT   F C C  GF
Sbjct: 415  HECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGF 473

Query: 2088 VLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDD 2147
            +++++ + C  +R  +C  + ++G                            CE    + 
Sbjct: 474  LINEDLKTC--SRVDYCLLS-DHG----------------------------CEYSCVNM 502

Query: 2148 EVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYT 2207
            + +F   CP GH  + S   T   ++ C      C +  C++++ SF C+C  GY L   
Sbjct: 503  DRSFACQCPEGH-VLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYILRED 560

Query: 2208 GVRCVDTDEC-SIGNPCGNGTCTNVIGSFECNCNEGF---EPGPMMNCEDINECAQNPLL 2263
            G  C   D C +I + C +  C N   S+ C C EGF   E G     +D+  C      
Sbjct: 561  GKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDV--CKSTHHG 617

Query: 2264 CAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEG 2301
            C   C+N   SY C C  G+ L ED + CK   +C EG
Sbjct: 618  CEHICVNNGNSYICKCSEGFVLAEDGRRCK---KCTEG 652



 Score =  188 bits (478), Expect = 6e-47
 Identities = 133/434 (30%), Positives = 186/434 (42%), Gaps = 37/434 (8%)

Query: 467 FSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYK 526
           F   + G+ V    QG I+       +  D+C    + C    C+    S+ C+C  GY 
Sbjct: 252 FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQCYSGYA 310

Query: 527 QDANGD-CIDVDECTS-NPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGV 584
              +G  C+ VD C S N     +CVN  GSY C+CH GF   P K+ C  ID C  +  
Sbjct: 311 LAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370

Query: 585 LCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICK 644
            C++  CVNTD S+ C C  GF L  D K C   + C          C+N + S+ C C 
Sbjct: 371 GCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCH 429

Query: 645 PGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRS 704
            G+ L PNG+ C+ VD C          C+N+E SF C C  G  +  D + C       
Sbjct: 430 RGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS------ 483

Query: 705 TCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITV 764
                 +   C+    G     E  C N D  F   CQ CP     E H L S G     
Sbjct: 484 ------RVDYCLLSDHGC----EYSCVNMDRSFA--CQ-CP-----EGHVLRSDGKTCA- 524

Query: 765 DGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNG 824
               ++ CAL    C +  C +   S+ C C  GY     G+ C   D C      C++ 
Sbjct: 525 ---KLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH- 579

Query: 825 LCRNTPGSYSCTCPPGYVFRTETETCEDINECES--NPCVNGACRNNLGSFNCECSPGSK 882
           +C N+  SY+C C  G+    + + C   + C+S  + C +  C NN  S+ C+CS G  
Sbjct: 580 ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFV 638

Query: 883 LSSTGLICIDSLKG 896
           L+  G  C    +G
Sbjct: 639 LAEDGRRCKKCTEG 652



 Score =  182 bits (462), Expect = 4e-45
 Identities = 127/468 (27%), Positives = 191/468 (40%), Gaps = 69/468 (14%)

Query: 539 CTSNPCTNGD------CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCV 592
           CT++ C+  +      C+N PGSY C+C  G+     +  C   D C      C+   CV
Sbjct: 237 CTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCV 295

Query: 593 NTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPN 652
           N  GSF C C +G+ L  DGK CV  D C + N      C+N DGS+ C C  GF L P+
Sbjct: 296 NVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPD 355

Query: 653 GRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKK 712
            + CT +D C +        C+N++ S+ C C  G  +  D + C     R   Y  + K
Sbjct: 356 KKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC-----RRINYCALNK 410

Query: 713 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRD---I 769
             C           E  C N +                 ++  C  G  +  +G+    +
Sbjct: 411 PGC-----------EHECVNME---------------ESYYCRCHRGYTLDPNGKTCSRV 444

Query: 770 NECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNT 829
           + CA     C   +C N   S+ C C+ G+  +   + C  +D CL++   C+   C N 
Sbjct: 445 DHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNM 502

Query: 830 PGSYSCTCPPGYVFRTETETCEDINECE--SNPCVNGACRNNLGSFNCECSPGSKLSSTG 887
             S++C CP G+V R++ +TC  ++ C    + C + +C ++  SF C+C  G  L   G
Sbjct: 503 DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYILREDG 561

Query: 888 LICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLAR 947
             C    K  C     D  CE     +     C    G       +RC     C     +
Sbjct: 562 KTC--RRKDVC--QAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVC-----K 612

Query: 948 IKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVC 995
                CE +              CVN+  S+ C+C EG  L   GR C
Sbjct: 613 STHHGCEHI--------------CVNNGNSYICKCSEGFVLAEDGRRC 646



 Score =  182 bits (462), Expect = 4e-45
 Identities = 122/401 (30%), Positives = 172/401 (42%), Gaps = 46/401 (11%)

Query: 1990 CFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEV 2049
            C N  GS+ C C +GY L  D   C   + C     +C    C N+ GSF C C  GY +
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311

Query: 2050 KSEN--CIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTN 2107
              +   C+ ++ C  + + C    C N  G + C C  GF L+ + + C           
Sbjct: 312  AEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC----------- 359

Query: 2108 FENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHD 2167
                          TK   C S   G      C+    + + ++   C  G    P    
Sbjct: 360  --------------TKIDYCASSNHG------CQHECVNTDDSYSCHCLKGFTLNPDKKT 399

Query: 2168 TREDVNEC-LESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNG 2226
             R  +N C L  PG C + +C+N + S+ C C  GY LD  G  C   D C+  +     
Sbjct: 400  CRR-INYCALNKPG-CEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ 456

Query: 2227 TCTNVIGSFECNCNEGFEPG-PMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYAL 2285
             C N   SF C C+EGF     +  C  ++ C  +   C + C+N   S+ C CP G+ L
Sbjct: 457  LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVL 516

Query: 2286 REDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTK 2345
            R D K C  LD CA G H CE     C +   +F+C C  G   R DG+ C  ++ C+  
Sbjct: 517  RSDGKTCAKLDSCALGDHGCEH---SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAI 573

Query: 2346 PGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLC 2386
               CE+  CVN   SY CEC EGF+ +  G  C   R+ +C
Sbjct: 574  DHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVC 611



 Score =  182 bits (461), Expect = 5e-45
 Identities = 101/322 (31%), Positives = 145/322 (45%), Gaps = 12/322 (3%)

Query: 2453 CKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGS 2512
            C  + + C +  CIN  GS+ C CK GY  +   T+C   D C+     C  +C N  GS
Sbjct: 242  CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300

Query: 2513 YQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQH--HTACI 2570
            + C C  GY L EDGK C  +D C ++ H C+  CVN  G + C+C  GF  +     C 
Sbjct: 301  FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360

Query: 2571 DNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHR-CQHGCQ 2629
              + C S  S  G +  C NT  S+SC C +GF+L+     C  ++ C  N   C+H C 
Sbjct: 361  KIDYCAS--SNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECV 418

Query: 2630 NILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQF 2689
            N+   Y C C +GY        C   + C+  +      C NT  S+ C C  GF  ++ 
Sbjct: 419  NMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINED 478

Query: 2690 SSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDT 2749
               C  V+ C  S + C Y C N +  + C CP G+     G   +     K    +L  
Sbjct: 479  LKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA-----KLDSCALGD 533

Query: 2750 EVDEENALSPEACYECK-INGY 2770
               E + +S E  + C+   GY
Sbjct: 534  HGCEHSCVSSEDSFVCQCFEGY 555



 Score =  181 bits (459), Expect = 9e-45
 Identities = 128/447 (28%), Positives = 186/447 (41%), Gaps = 44/447 (9%)

Query: 1941 HPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCL 2000
            H C +  C N  GSY C C  G+ L  +     I +  +     C    C N  GSF C 
Sbjct: 247  HNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQ 304

Query: 2001 CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDIN 2058
            C  GY L  DGK C+  + C +    C    C N +GS+ C C  G+ +  +   C  I+
Sbjct: 305  CYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKID 363

Query: 2059 ECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKA 2118
             C    + C    C NT   + C C  GF L+ + + C   R ++C  N           
Sbjct: 364  YCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTC--RRINYCALN----------- 409

Query: 2119 FNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLES 2178
                         PG      CE    + E ++   C  G+   P+   T   V+ C + 
Sbjct: 410  ------------KPG------CEHECVNMEESYYCRCHRGYTLDPN-GKTCSRVDHCAQQ 450

Query: 2179 PGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECN 2238
               C    C+NT+ SF C+C  G+ ++     C   D C + +     +C N+  SF C 
Sbjct: 451  DHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQ 509

Query: 2239 CNEGFE-PGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDE 2297
            C EG         C  ++ CA     C   C+++  S+ C C  GY LRED K C+  D 
Sbjct: 510  CPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDV 569

Query: 2298 CAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNI 2357
            C    H CE    +C N   ++ C C  G     DG+ C  ++ C++    CE+  CVN 
Sbjct: 570  CQAIDHGCEH---ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNN 625

Query: 2358 IGSYRCECNEGFQSSSSGTECLDNRQG 2384
              SY C+C+EGF  +  G  C    +G
Sbjct: 626  GNSYICKCSEGFVLAEDGRRCKKCTEG 652



 Score =  157 bits (396), Expect = 2e-37
 Identities = 114/440 (25%), Positives = 170/440 (38%), Gaps = 65/440 (14%)

Query: 1465 CLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELD 1524
            C+N+PG+Y C C+ G+   SD  +C+  D C+ ++      C N+PG F C C  GY L 
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312

Query: 1525 RTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFG 1584
              G  C  +D CA   +     CVN  G Y C C   F LNP    C   ++  C     
Sbjct: 313  EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC--TKIDYC----- 365

Query: 1585 PRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN----------------STE 1628
                 +  C  E        SC C  G       +TC  +N                   
Sbjct: 366  --ASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEES 423

Query: 1629 YYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTR 1688
            YY  C  G    PN  T     +D C +    C+   C+NT  SF C+C +G+ ++ED +
Sbjct: 424  YYCRCHRGYTLDPNGKT--CSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLK 480

Query: 1689 ICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTT 1748
             C  +D C      C   +C N   ++ C CP  ++  + G  C  +    C    +G  
Sbjct: 481  TCSRVDYCLLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDGKTCAKL--DSCALGDHG-- 535

Query: 1749 CENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVD 1808
            CE+    +    +C C                               G+           
Sbjct: 536  CEHSCVSSEDSFVCQC-----------------------------FEGYILREDGKTCRR 566

Query: 1809 IDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCI 1868
             D C+ I   C + +C+N   S+ CEC  GF   +    C   D C +  + C+    C+
Sbjct: 567  KDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH--ICV 623

Query: 1869 NSPGSYRCECAAGFKLSPNG 1888
            N+  SY C+C+ GF L+ +G
Sbjct: 624  NNGNSYICKCSEGFVLAEDG 643



 Score =  155 bits (392), Expect = 6e-37
 Identities = 127/466 (27%), Positives = 176/466 (37%), Gaps = 79/466 (16%)

Query: 1506 CNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLN 1565
            C N+PG + C C  GY L+     C   D CA   +    LCVN PG + C C   + L 
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312

Query: 1566 PTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN 1625
              G  CV                                  C S      + C     VN
Sbjct: 313  EDGKRCV------------------------------AVDYCASENHGCEHEC-----VN 337

Query: 1626 STEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSE 1685
            +   Y LC   EGF  NP       ID C      CQ   C+NT  S+ C C +G+ L+ 
Sbjct: 338  ADGSY-LCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNP 395

Query: 1686 DTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYN 1745
            D + C  I+ C  +   C    C N   +Y C C   Y     G  C   R   C +  +
Sbjct: 396  DKKTCRRINYCALNKPGC-EHECVNMEESYYCRCHRGYTLDPNGKTCS--RVDHCAQQDH 452

Query: 1746 GTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGK 1805
            G  CE         ++C  T +                      +C    GF  +     
Sbjct: 453  G--CE---------QLCLNTED--------------------SFVCQCSEGFLINEDLKT 481

Query: 1806 AVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNA 1865
               +D C      C    C+N   SF C+CP G         C  +D C+ GD+ C+ + 
Sbjct: 482  CSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS- 539

Query: 1866 DCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFK 1924
             C++S  S+ C+C  G+ L  +G  C  ++ C  I + C H +CV+   SY C C  GF+
Sbjct: 540  -CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFR 597

Query: 1925 ASQDQTMCMDVDECE--RHPCGNGTCKNTVGSYNCLCYPGFELTHN 1968
             ++D   C   D C+   H C +  C N   SY C C  GF L  +
Sbjct: 598  LAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAED 642



 Score =  151 bits (382), Expect = 8e-36
 Identities = 127/478 (26%), Positives = 184/478 (38%), Gaps = 86/478 (17%)

Query: 779  CANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCP 838
            CA+  C N+ GSY C C  GY  ++    C   D C +    C+  LC N PGS+ C C 
Sbjct: 249  CAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCY 306

Query: 839  PGYVFRTETETCEDINECES-NPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGT 897
             GY    + + C  ++ C S N      C N  GS+ C+C  G  L+          K T
Sbjct: 307  SGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPD--------KKT 358

Query: 898  CWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVT----- 952
            C                  K + CA+        C   +   +C      +KG T     
Sbjct: 359  C-----------------TKIDYCASSNHGCQHECVNTDDSYSCHC----LKGFTLNPDK 397

Query: 953  --CEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDED 1010
              C  +N C +    C +  CVN + S++C C  G TLD  G+ C  +           D
Sbjct: 398  KTCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRV-----------D 445

Query: 1011 ECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPF 1070
             C     G    +  C     ++  +C E                 GF    D+ T    
Sbjct: 446  HCAQQDHG---CEQLCLNTEDSFVCQCSE-----------------GFLINEDLKT---- 481

Query: 1071 YKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGI 1130
               ++ C      C Y  C N   SF C+C  G  L  + + C  +D C +    C    
Sbjct: 482  CSRVDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS- 539

Query: 1131 CVNTPGSFECECFEGY---ESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPL 1187
            CV++  SF C+CFEGY   E G    K C   D C+     C    CVN++ S+ C+C  
Sbjct: 540  CVSSEDSFVCQCFEGYILREDG----KTCRRKDVCQAIDHGCE-HICVNSDDSYTCECLE 594

Query: 1188 GHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDE 1245
            G  L+   + C   + C  + + C +  CVN   +Y C C+ G+    D + C    E
Sbjct: 595  GFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651



 Score =  138 bits (348), Expect = 7e-32
 Identities = 88/298 (29%), Positives = 124/298 (41%), Gaps = 22/298 (7%)

Query: 495 IDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGD-CIDVDECTSN-PCTNGDCVNT 552
           ID C    + C +  C+ T  SY C C  G+  + +   C  ++ C  N P    +CVN 
Sbjct: 362 IDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 420

Query: 553 PGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDG 612
             SYYC+CH G+   P  + C  +D C Q    C+   C+NT+ SF C C+ GF +  D 
Sbjct: 421 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDL 479

Query: 613 KNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGH 672
           K C   D C  ++      C+N D SF C C  G VL  +G+ C  +D C          
Sbjct: 480 KTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS 539

Query: 673 CINSEGSFRCDCPPGLAVGMDGRVC--------VDTHMRSTCYGGIKKGVC--VRPFPGA 722
           C++SE SF C C  G  +  DG+ C        +D      C        C  +  F  A
Sbjct: 540 CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLA 599

Query: 723 VTKSEC----CCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDP 776
                C     C +  +G    C+     N   +   CS G  +  DGR   +C   P
Sbjct: 600 EDGKRCRRKDVCKSTHHG----CEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653



 Score = 79.3 bits (194), Expect = 5e-14
 Identities = 77/311 (24%), Positives = 111/311 (35%), Gaps = 67/311 (21%)

Query: 87  NVCGSRFHSYCCPGWKTLPGGNQCI-VPICRNS------------------CGDGFCSRP 127
           NV GS F   C  G+     G +C+ V  C +                   C +GF   P
Sbjct: 296 NVPGS-FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNP 354

Query: 128 NMCTCSSGQISSTCGSKSIQQC-------SVRCMNGGTCADDHCQCQKGYIGTYCG--QP 178
           +  TC+     ++       +C       S  C+ G T   D   C++     YC   +P
Sbjct: 355 DKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRI---NYCALNKP 411

Query: 179 VCENGCQNGGRCIGPNRCACVYGFT-GPQCERDYRTGPCFTQVNN--QMCQGQLTGIVCT 235
            CE+ C N         C C  G+T  P  +   R   C  Q +   Q+C       VC 
Sbjct: 412 GCEHECVNMEESY---YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ 468

Query: 236 KTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINT 295
                                    C  GF+ N     C  VD C      C+  +C+N 
Sbjct: 469 -------------------------CSEGFLINEDLKTCSRVDYCLLSDHGCEY-SCVNM 502

Query: 296 VGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDG 355
             SF C+CP GH      + C  +D C++    CE   C ++  S+ C C  GY+   DG
Sbjct: 503 DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE-HSCVSSEDSFVCQCFEGYILREDG 561

Query: 356 SRCIDQRTGMC 366
             C  +R  +C
Sbjct: 562 KTC--RRKDVC 570



 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 49/166 (29%), Positives = 69/166 (41%), Gaps = 11/166 (6%)

Query: 233 VCTKTLC----CATIGRAWGHPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGIC 287
           V  K LC    C+T+     H C   P      C++G+I N     C+  D C      C
Sbjct: 231 VFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC 290

Query: 288 QGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPR 347
           +   C+N  GSF C+C +G+  +E  ++C  +D C+     CE  EC N  GSY C C  
Sbjct: 291 EQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHE 348

Query: 348 GYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
           G+  + D   C    T + +    N  C  E         C C  G
Sbjct: 349 GFALNPDKKTC----TKIDYCASSNHGCQHECVNTDDSYSCHCLKG 390



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 69/257 (26%), Positives = 88/257 (34%), Gaps = 49/257 (19%)

Query: 115 CRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGT- 173
           CR  C  G+   PN  TCS       C  +    C   C+N  T     CQC +G++   
Sbjct: 426 CR--CHRGYTLDPNGKTCSR---VDHCAQQD-HGCEQLCLN--TEDSFVCQCSEGFLINE 477

Query: 174 ---------YC--GQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNN 222
                    YC      CE  C N  R      C C  G                     
Sbjct: 478 DLKTCSRVDYCLLSDHGCEYSCVNMDRSFA---CQCPEGHVL------------------ 516

Query: 223 QMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ-PQPCRRGFIPNIRTGACQDVDECQ 281
                +  G  C K   CA       H C          C  G+I       C+  D CQ
Sbjct: 517 -----RSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571

Query: 282 AIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSY 341
           AI   C+   C+N+  S+ C C  G + +E  ++C   D C      CE   C N   SY
Sbjct: 572 AIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSY 629

Query: 342 FCVCPRGYVTSTDGSRC 358
            C C  G+V + DG RC
Sbjct: 630 ICKCSEGFVLAEDGRRC 646


>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
          Length = 956

 Score =  276 bits (705), Expect = 3e-73
 Identities = 147/413 (35%), Positives = 210/413 (50%), Gaps = 21/413 (5%)

Query: 1089 CRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGY-- 1146
            C N  GS+ CRC  G+ L+ ++  C   D C +    C   +CVN PGSF C+C+ GY  
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311

Query: 1147 -ESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECS 1205
             E G    K C+ +D C      C    CVN +GS+ C C  G  L+P ++ C  I+ C+
Sbjct: 312  AEDG----KRCVAVDYCASENHGCE-HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCA 366

Query: 1206 LSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYE 1265
             S++ C++ +CVN   +Y C C  G+   PD++ C  I+ C +   GC+ +C N E SY 
Sbjct: 367  SSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425

Query: 1266 CSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCID 1325
            C C  GY L P+G++C+ +D C      C+   C N    + C C +GF+ + D+KTC  
Sbjct: 426  CRCHRGYTLDPNGKTCSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSR 484

Query: 1326 VNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCL 1385
            V+ C L+ + C +  C N   SF C C  G+ ++     C  +D C +G H C+   SC+
Sbjct: 485  VDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE--HSCV 541

Query: 1386 NIPGSFKCSCREGWI--GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF--T 1441
            +   SF C C EG+I   +G  C   D C    H C     CVN+  SY C C EGF   
Sbjct: 542  SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC--EHICVNSDDSYTCECLEGFRLA 599

Query: 1442 GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDE 1494
             DG  C   D C    + CE+  C+N   +Y C+C  GF  A D R C+   E
Sbjct: 600  EDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651



 Score =  259 bits (662), Expect = 3e-68
 Identities = 143/417 (34%), Positives = 205/417 (49%), Gaps = 16/417 (3%)

Query: 1131 CVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1190
            C+N PGS+ C C +GY         C   D C      C    CVN  GSF C C  G+ 
Sbjct: 253  CINIPGSYVCRCKQGYILN-SDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYA 310

Query: 1191 LSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMN 1250
            L+   + CV ++ C+  ++ C + +CVN  G+Y C C+ G+   PD++ CT ID C   N
Sbjct: 311  LAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369

Query: 1251 GGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLC 1310
             GC  +C N++ SY C C +G+ L PD ++C  I+ C  N   C+  +C N+   Y C C
Sbjct: 370  HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE-HECVNMEESYYCRC 428

Query: 1311 YDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDE 1370
            + G+    + KTC  V+ C    + C    C NT+ SF+C C  G+ + +    C+ VD 
Sbjct: 429  HRGYTLDPNGKTCSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487

Query: 1371 CEIGAHNCDMHASCLNIPGSFKCSCREGWI--GNGIKCIDLDECSNGTHQCSINAQCVNT 1428
            C +  H C+   SC+N+  SF C C EG +   +G  C  LD C+ G H C     CV++
Sbjct: 488  CLLSDHGCEY--SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVSS 543

Query: 1429 PGSYRCACSEGF--TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDS 1486
              S+ C C EG+    DG TC   D C    + CE+  C+N   +Y CEC  GF  A D 
Sbjct: 544  EDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDG 602

Query: 1487 RSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCV 1543
            + C+  D C   +      C N    + C C +G+ L   G  C    E   PI+ V
Sbjct: 603  KRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE--GPIDLV 657



 Score =  253 bits (645), Expect = 3e-66
 Identities = 142/422 (33%), Positives = 199/422 (47%), Gaps = 12/422 (2%)

Query: 1174 CVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQA 1233
            C+N  GS+ C C  G+ L+  +  C   + C++ D+ C    CVN+ G++ C C  GY  
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311

Query: 1234 TPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDI 1293
              D + C  +D C   N GC+ +C N++GSY C C EG+AL PD ++C  ID C ++   
Sbjct: 312  AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371

Query: 1294 CDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQ 1353
            C   +C N    Y C C  GF  + D KTC  +N C LN   C   EC N + S+ C C 
Sbjct: 372  CQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCH 429

Query: 1354 LGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGN-GIK-CIDLDE 1411
             GY++      C+ VD C    H C+    CLN   SF C C EG++ N  +K C  +D 
Sbjct: 430  RGYTLDPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487

Query: 1412 CSNGTHQCSINAQCVNTPGSYRCACSEGFT--GDGFTCSDVDECAENINLCENGQCLNVP 1469
            C    H C  +  CVN   S+ C C EG     DG TC+ +D CA   + CE+  C++  
Sbjct: 488  CLLSDHGCEYS--CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSE 544

Query: 1470 GAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGN 1529
             ++ C+C  G+    D ++C+  D C   +      C N    + C C +G+ L   G  
Sbjct: 545  DSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKR 604

Query: 1530 CTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDG 1589
            C   D C    +    +CVN    Y C C   F L   G  C     G   L F   G  
Sbjct: 605  CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSK 664

Query: 1590 SL 1591
            SL
Sbjct: 665  SL 666



 Score =  234 bits (598), Expect = 7e-61
 Identities = 139/443 (31%), Positives = 191/443 (43%), Gaps = 48/443 (10%)

Query: 2264 CAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCIC 2323
            CA  C+N  GSY C C  GY L  DQ  C+  D CA   H+CE    +C N+ G+F+C C
Sbjct: 249  CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ---LCVNVPGSFVCQC 305

Query: 2324 PPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQ 2383
              G A   DG+ CV  + C ++   CE+  CVN  GSY C+C+EGF  +     C     
Sbjct: 306  YSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC----- 359

Query: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGY 2443
                                  TK + C     G  H+C    +     Y   C  G   
Sbjct: 360  ----------------------TKIDYCASSNHGCQHEC----VNTDDSYSCHCLKGFTL 393

Query: 2444 TTDG---RDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPK 2500
              D    R I+ C +    C + +C+N   S+ C C  GYT D +G +C  +D C+Q   
Sbjct: 394  NPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDH 452

Query: 2501 PCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPP 2560
             C  +C NTE S+ C C  G+++ ED KTC  +D C    H C++ CVN    F C+CP 
Sbjct: 453  GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE 512

Query: 2561 GFTQHHTACIDNNECGSQPSLC----GAKGICQNTPGSFSCECQRGFSLDATGLNCEDVD 2616
            G    H    D   C    S      G +  C ++  SF C+C  G+ L   G  C   D
Sbjct: 513  G----HVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKD 568

Query: 2617 ECDG-NHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGS 2675
             C   +H C+H C N    Y C C +G+       +C  ++ C + +      C N   S
Sbjct: 569  VCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNS 628

Query: 2676 YKCACPSGFSFDQFSSACHDVNE 2698
            Y C C  GF   +    C    E
Sbjct: 629  YICKCSEGFVLAEDGRRCKKCTE 651



 Score =  211 bits (538), Expect = 6e-54
 Identities = 135/460 (29%), Positives = 197/460 (42%), Gaps = 60/460 (13%)

Query: 1246 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGE 1305
            C  +   C   C N  GSY C C +GY L  D  +C   D C      C+   C N+PG 
Sbjct: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE-QLCVNVPGS 300

Query: 1306 YRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGC 1365
            + C CY G+  + D K C+ V+ C   ++ C   EC N  GS++C C  G+++      C
Sbjct: 301  FVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC 359

Query: 1366 TDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIK--CIDLDECSNGTHQCSINA 1423
            T +D C    H C     C+N   S+ C C +G+  N  K  C  ++ C+     C    
Sbjct: 360  TKIDYCASSNHGC--QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC--EH 415

Query: 1424 QCVNTPGSYRCACSEGFTGD--GFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFT 1481
            +CVN   SY C C  G+T D  G TCS VD CA+  + CE   CLN   ++ C+C  GF 
Sbjct: 416  ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFL 474

Query: 1482 PASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPIN 1541
               D ++C  +D C   +     +C N+   F C C +G+ L   G  C  +D CA   +
Sbjct: 475  INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534

Query: 1542 CVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGV 1601
                 CV++   + C C   + L   G  C                              
Sbjct: 535  GCEHSCVSSEDSFVCQCFEGYILREDGKTC------------------------------ 564

Query: 1602 SRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLC 1661
             R   C ++     + C     VNS + YT C   EGFR      + ED   C+    +C
Sbjct: 565  RRKDVCQAIDHGCEHIC-----VNSDDSYT-CECLEGFR------LAEDGKRCRR-KDVC 611

Query: 1662 QGGN------CINTFGSFQCECPQGYYLSEDTRICEDIDE 1695
            +  +      C+N   S+ C+C +G+ L+ED R C+   E
Sbjct: 612  KSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651



 Score =  207 bits (528), Expect = 9e-53
 Identities = 119/380 (31%), Positives = 167/380 (43%), Gaps = 40/380 (10%)

Query: 2187 CINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPG 2246
            C+N  GSF C+C  GY L   G RCV  D C+  N      C N  GS+ C C+EGF   
Sbjct: 294  CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353

Query: 2247 P-MMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDC 2305
            P    C  I+ CA +   C   C+NT  SY C C  G+ L  D+K C+ ++ CA     C
Sbjct: 354  PDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413

Query: 2306 ESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCEC 2365
            E     C N+  ++ C C  G    P+G+ C   + C  +   CE   C+N   S+ C+C
Sbjct: 414  EHE---CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQC 469

Query: 2366 NEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELC 2425
            +EGF  +     C  +R   C                                 H CE  
Sbjct: 470  SEGFLINEDLKTC--SRVDYCLLS-----------------------------DHGCEYS 498

Query: 2426 PLPGTAQYKKICPHGPGYTTDGR---DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTT 2482
             +     +   CP G    +DG+    +D C +  + C +  C+++  SF C C  GY  
Sbjct: 499  CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYIL 557

Query: 2483 DISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHN 2542
               G +C   D C      C +IC N++ SY C C  G+ L EDGK C+  D C++  H 
Sbjct: 558  REDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG 617

Query: 2543 CQFLCVNTLGGFTCKCPPGF 2562
            C+ +CVN    + CKC  GF
Sbjct: 618  CEHICVNNGNSYICKCSEGF 637



 Score =  207 bits (527), Expect = 1e-52
 Identities = 138/452 (30%), Positives = 205/452 (45%), Gaps = 55/452 (12%)

Query: 1341 CENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWI 1400
            C N  GS++C C+ GY +    T C   D C +  HNC+    C+N+PGSF C C  G+ 
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVPGSFVCQCYSGYA 310

Query: 1401 --GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT--GDGFTCSDVDECAEN 1456
               +G +C+ +D C++  H C    +CVN  GSY C C EGF    D  TC+ +D CA +
Sbjct: 311  LAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASS 368

Query: 1457 INLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCI 1516
             + C++ +C+N   +Y C C  GFT   D ++C+ I+ C+         C N+   ++C 
Sbjct: 369  NHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCR 427

Query: 1517 CDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRV 1576
            C  GY LD  G  C+ +D CA   +    LC+NT   + C C   F +N     C  +RV
Sbjct: 428  CHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTC--SRV 485

Query: 1577 GNCYLKFGPRGDGSLSCNTEIGVGVSRS-SCCCSLGKAWGNPCETCPPVNSTEYYTLCPG 1635
              C L          SC     V + RS +C C  G    +  +TC  ++S      C  
Sbjct: 486  DYCLLS---DHGCEYSC-----VNMDRSFACQCPEGHVLRSDGKTCAKLDS------CAL 531

Query: 1636 GEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDE 1695
            G+                C+         +C+++  SF C+C +GY L ED + C   D 
Sbjct: 532  GD--------------HGCEH--------SCVSSEDSFVCQCFEGYILREDGKTCRRKDV 569

Query: 1696 CFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPF 1755
            C A    C    C N+  +YTC C   +     G  C   RK  C  +++G  CE+    
Sbjct: 570  CQAIDHGC-EHICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVCKSTHHG--CEHICVN 624

Query: 1756 NVTKRMCCCTYNVGKAWN-KPCEPCPTPGTAD 1786
            N    +C C+     A + + C+ C T G  D
Sbjct: 625  NGNSYICKCSEGFVLAEDGRRCKKC-TEGPID 655



 Score =  207 bits (527), Expect = 1e-52
 Identities = 127/450 (28%), Positives = 203/450 (45%), Gaps = 55/450 (12%)

Query: 971  CVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWD---EDECIHPVPGKFRMDACCC 1027
            C+N  GS+ C C +G  L+     C   R++      D   E  C++ VPG F    C C
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTC---RIQDLCAMEDHNCEQLCVN-VPGSF---VCQC 305

Query: 1028 AVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYG 1087
              G A   + + C                                 ++ C +    C + 
Sbjct: 306  YSGYALAEDGKRCVA-------------------------------VDYCASENHGCEH- 333

Query: 1088 KCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYE 1147
            +C N  GS+ C+C+ GFAL+ +++ CT ID C  S   C    CVNT  S+ C C +G+ 
Sbjct: 334  ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGC-QHECVNTDDSYSCHCLKGFT 392

Query: 1148 SGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLS 1207
                  K C  I+ C  N   C    CVN E S+ C C  G+ L P+ + C  ++ C+  
Sbjct: 393  LN-PDKKTCRRINYCALNKPGCE-HECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQ 450

Query: 1208 DNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECS 1267
            D+ C    C+N   ++ C C+ G+    D + C+ +D C++ + GC+  C N + S+ C 
Sbjct: 451  DHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQ 509

Query: 1268 CSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVN 1327
            C EG+ L  DG++CA +D C      C+   C +    + C C++G++   D KTC   +
Sbjct: 510  CPEGHVLRSDGKTCAKLDSCALGDHGCE-HSCVSSEDSFVCQCFEGYILREDGKTCRRKD 568

Query: 1328 ECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNI 1387
             C    + C    C N+  S+ C C  G+ + +    C   D C+   H C+    C+N 
Sbjct: 569  VCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCE--HICVNN 625

Query: 1388 PGSFKCSCREGWI--GNGIKCIDLDECSNG 1415
              S+ C C EG++   +G +C    +C+ G
Sbjct: 626  GNSYICKCSEGFVLAEDGRRC---KKCTEG 652



 Score =  206 bits (524), Expect = 3e-52
 Identities = 123/443 (27%), Positives = 184/443 (41%), Gaps = 50/443 (11%)

Query: 2298 CAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNI 2357
            C+   H+C      C N+ G+++C C  G     D   C  ++ C  +   CE   CVN+
Sbjct: 242  CSTLEHNCAH---FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNV 297

Query: 2358 IGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRG 2417
             GS+ C+C  G+  +  G  C+                             + C     G
Sbjct: 298  PGSFVCQCYSGYALAEDGKRCV---------------------------AVDYCASENHG 330

Query: 2418 WGHQCELCPLPGTAQYKKICPHGPGYTTDGRD---IDECKVMPNLCTNGQCINTMGSFRC 2474
              H+C    +     Y   C  G     D +    ID C    + C + +C+NT  S+ C
Sbjct: 331  CEHEC----VNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSC 385

Query: 2475 FCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLD 2534
             C  G+T +    +C  ++ C+ +   C + C N E SY C C RGY L  +GKTC  +D
Sbjct: 386  HCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVD 445

Query: 2535 ECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLC-----GAKGICQ 2589
             C  + H C+ LC+NT   F C+C  GF  +     D   C S+   C     G +  C 
Sbjct: 446  HCAQQDHGCEQLCLNTEDSFVCQCSEGFLINE----DLKTC-SRVDYCLLSDHGCEYSCV 500

Query: 2590 NTPGSFSCECQRGFSLDATGLNCEDVDECD-GNHRCQHGCQNILGGYRCGCPQGYIQHYQ 2648
            N   SF+C+C  G  L + G  C  +D C  G+H C+H C +    + C C +GYI    
Sbjct: 501  NMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRED 560

Query: 2649 WNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNY 2708
               C  ++ C   +      C N+  SY C C  GF   +    C   + C S+ + C +
Sbjct: 561  GKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH 620

Query: 2709 GCSNTEGGYLCGCPPGYYRVGQG 2731
             C N    Y+C C  G+     G
Sbjct: 621  ICVNNGNSYICKCSEGFVLAEDG 643



 Score =  190 bits (482), Expect = 2e-47
 Identities = 140/458 (30%), Positives = 204/458 (44%), Gaps = 57/458 (12%)

Query: 1854 CSNGDNLCQRNADCINSPGSYRCECAAGFKL-SPNGACVDRNECLEIPNVCSHGLCVDLQ 1912
            CS  ++ C     CIN PGSY C C  G+ L S    C  ++ C    + C   LCV++ 
Sbjct: 242  CSTLEHNCAHF--CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVP 298

Query: 1913 GSYQCICHNGFKASQDQTMCMDVDEC--ERHPCGNGTCKNTVGSYNCLCYPGFELT-HNN 1969
            GS+ C C++G+  ++D   C+ VD C  E H C +  C N  GSY C C+ GF L     
Sbjct: 299  GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKK 357

Query: 1970 DCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSP 2029
             C  ID C+S     C++  C N   S+ C C +G+ L PD K C   N C      C  
Sbjct: 358  TCTKIDYCAS-SNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE- 414

Query: 2030 GTCQNLEGSFRCICPPGY--EVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGF 2087
              C N+E S+ C C  GY  +   + C  ++ C +  + C    C NT   F C C  GF
Sbjct: 415  HECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGF 473

Query: 2088 VLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDD 2147
            +++++ + C  +R  +C  + ++G                            CE    + 
Sbjct: 474  LINEDLKTC--SRVDYCLLS-DHG----------------------------CEYSCVNM 502

Query: 2148 EVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYT 2207
            + +F   CP GH  + S   T   ++ C      C +  C++++ SF C+C  GY L   
Sbjct: 503  DRSFACQCPEGH-VLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYILRED 560

Query: 2208 GVRCVDTDEC-SIGNPCGNGTCTNVIGSFECNCNEGF---EPGPMMNCEDINECAQNPLL 2263
            G  C   D C +I + C +  C N   S+ C C EGF   E G     +D+  C      
Sbjct: 561  GKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDV--CKSTHHG 617

Query: 2264 CAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEG 2301
            C   C+N   SY C C  G+ L ED + CK   +C EG
Sbjct: 618  CEHICVNNGNSYICKCSEGFVLAEDGRRCK---KCTEG 652



 Score =  188 bits (478), Expect = 6e-47
 Identities = 133/434 (30%), Positives = 186/434 (42%), Gaps = 37/434 (8%)

Query: 467 FSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYK 526
           F   + G+ V    QG I+       +  D+C    + C    C+    S+ C+C  GY 
Sbjct: 252 FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQCYSGYA 310

Query: 527 QDANGD-CIDVDECTS-NPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGV 584
              +G  C+ VD C S N     +CVN  GSY C+CH GF   P K+ C  ID C  +  
Sbjct: 311 LAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370

Query: 585 LCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICK 644
            C++  CVNTD S+ C C  GF L  D K C   + C          C+N + S+ C C 
Sbjct: 371 GCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCH 429

Query: 645 PGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRS 704
            G+ L PNG+ C+ VD C          C+N+E SF C C  G  +  D + C       
Sbjct: 430 RGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS------ 483

Query: 705 TCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITV 764
                 +   C+    G     E  C N D  F   CQ CP     E H L S G     
Sbjct: 484 ------RVDYCLLSDHGC----EYSCVNMDRSFA--CQ-CP-----EGHVLRSDGKTCA- 524

Query: 765 DGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNG 824
               ++ CAL    C +  C +   S+ C C  GY     G+ C   D C      C++ 
Sbjct: 525 ---KLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH- 579

Query: 825 LCRNTPGSYSCTCPPGYVFRTETETCEDINECES--NPCVNGACRNNLGSFNCECSPGSK 882
           +C N+  SY+C C  G+    + + C   + C+S  + C +  C NN  S+ C+CS G  
Sbjct: 580 ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFV 638

Query: 883 LSSTGLICIDSLKG 896
           L+  G  C    +G
Sbjct: 639 LAEDGRRCKKCTEG 652



 Score =  182 bits (462), Expect = 4e-45
 Identities = 127/468 (27%), Positives = 191/468 (40%), Gaps = 69/468 (14%)

Query: 539 CTSNPCTNGD------CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCV 592
           CT++ C+  +      C+N PGSY C+C  G+     +  C   D C      C+   CV
Sbjct: 237 CTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCV 295

Query: 593 NTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPN 652
           N  GSF C C +G+ L  DGK CV  D C + N      C+N DGS+ C C  GF L P+
Sbjct: 296 NVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPD 355

Query: 653 GRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKK 712
            + CT +D C +        C+N++ S+ C C  G  +  D + C     R   Y  + K
Sbjct: 356 KKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC-----RRINYCALNK 410

Query: 713 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRD---I 769
             C           E  C N +                 ++  C  G  +  +G+    +
Sbjct: 411 PGC-----------EHECVNME---------------ESYYCRCHRGYTLDPNGKTCSRV 444

Query: 770 NECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNT 829
           + CA     C   +C N   S+ C C+ G+  +   + C  +D CL++   C+   C N 
Sbjct: 445 DHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNM 502

Query: 830 PGSYSCTCPPGYVFRTETETCEDINECE--SNPCVNGACRNNLGSFNCECSPGSKLSSTG 887
             S++C CP G+V R++ +TC  ++ C    + C + +C ++  SF C+C  G  L   G
Sbjct: 503 DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYILREDG 561

Query: 888 LICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLAR 947
             C    K  C     D  CE     +     C    G       +RC     C     +
Sbjct: 562 KTC--RRKDVC--QAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVC-----K 612

Query: 948 IKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVC 995
                CE +              CVN+  S+ C+C EG  L   GR C
Sbjct: 613 STHHGCEHI--------------CVNNGNSYICKCSEGFVLAEDGRRC 646



 Score =  182 bits (462), Expect = 4e-45
 Identities = 122/401 (30%), Positives = 172/401 (42%), Gaps = 46/401 (11%)

Query: 1990 CFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEV 2049
            C N  GS+ C C +GY L  D   C   + C     +C    C N+ GSF C C  GY +
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311

Query: 2050 KSEN--CIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTN 2107
              +   C+ ++ C  + + C    C N  G + C C  GF L+ + + C           
Sbjct: 312  AEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC----------- 359

Query: 2108 FENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHD 2167
                          TK   C S   G      C+    + + ++   C  G    P    
Sbjct: 360  --------------TKIDYCASSNHG------CQHECVNTDDSYSCHCLKGFTLNPDKKT 399

Query: 2168 TREDVNEC-LESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNG 2226
             R  +N C L  PG C + +C+N + S+ C C  GY LD  G  C   D C+  +     
Sbjct: 400  CRR-INYCALNKPG-CEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ 456

Query: 2227 TCTNVIGSFECNCNEGFEPG-PMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYAL 2285
             C N   SF C C+EGF     +  C  ++ C  +   C + C+N   S+ C CP G+ L
Sbjct: 457  LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVL 516

Query: 2286 REDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTK 2345
            R D K C  LD CA G H CE     C +   +F+C C  G   R DG+ C  ++ C+  
Sbjct: 517  RSDGKTCAKLDSCALGDHGCEH---SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAI 573

Query: 2346 PGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLC 2386
               CE+  CVN   SY CEC EGF+ +  G  C   R+ +C
Sbjct: 574  DHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVC 611



 Score =  182 bits (461), Expect = 5e-45
 Identities = 101/322 (31%), Positives = 145/322 (45%), Gaps = 12/322 (3%)

Query: 2453 CKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGS 2512
            C  + + C +  CIN  GS+ C CK GY  +   T+C   D C+     C  +C N  GS
Sbjct: 242  CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300

Query: 2513 YQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQH--HTACI 2570
            + C C  GY L EDGK C  +D C ++ H C+  CVN  G + C+C  GF  +     C 
Sbjct: 301  FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360

Query: 2571 DNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHR-CQHGCQ 2629
              + C S  S  G +  C NT  S+SC C +GF+L+     C  ++ C  N   C+H C 
Sbjct: 361  KIDYCAS--SNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECV 418

Query: 2630 NILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQF 2689
            N+   Y C C +GY        C   + C+  +      C NT  S+ C C  GF  ++ 
Sbjct: 419  NMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINED 478

Query: 2690 SSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDT 2749
               C  V+ C  S + C Y C N +  + C CP G+     G   +     K    +L  
Sbjct: 479  LKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA-----KLDSCALGD 533

Query: 2750 EVDEENALSPEACYECK-INGY 2770
               E + +S E  + C+   GY
Sbjct: 534  HGCEHSCVSSEDSFVCQCFEGY 555



 Score =  181 bits (459), Expect = 9e-45
 Identities = 128/447 (28%), Positives = 186/447 (41%), Gaps = 44/447 (9%)

Query: 1941 HPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCL 2000
            H C +  C N  GSY C C  G+ L  +     I +  +     C    C N  GSF C 
Sbjct: 247  HNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQ 304

Query: 2001 CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDIN 2058
            C  GY L  DGK C+  + C +    C    C N +GS+ C C  G+ +  +   C  I+
Sbjct: 305  CYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKID 363

Query: 2059 ECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKA 2118
             C    + C    C NT   + C C  GF L+ + + C   R ++C  N           
Sbjct: 364  YCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTC--RRINYCALN----------- 409

Query: 2119 FNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLES 2178
                         PG      CE    + E ++   C  G+   P+   T   V+ C + 
Sbjct: 410  ------------KPG------CEHECVNMEESYYCRCHRGYTLDPN-GKTCSRVDHCAQQ 450

Query: 2179 PGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECN 2238
               C    C+NT+ SF C+C  G+ ++     C   D C + +     +C N+  SF C 
Sbjct: 451  DHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQ 509

Query: 2239 CNEGFE-PGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDE 2297
            C EG         C  ++ CA     C   C+++  S+ C C  GY LRED K C+  D 
Sbjct: 510  CPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDV 569

Query: 2298 CAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNI 2357
            C    H CE    +C N   ++ C C  G     DG+ C  ++ C++    CE+  CVN 
Sbjct: 570  CQAIDHGCEH---ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNN 625

Query: 2358 IGSYRCECNEGFQSSSSGTECLDNRQG 2384
              SY C+C+EGF  +  G  C    +G
Sbjct: 626  GNSYICKCSEGFVLAEDGRRCKKCTEG 652



 Score =  157 bits (396), Expect = 2e-37
 Identities = 114/440 (25%), Positives = 170/440 (38%), Gaps = 65/440 (14%)

Query: 1465 CLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELD 1524
            C+N+PG+Y C C+ G+   SD  +C+  D C+ ++      C N+PG F C C  GY L 
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312

Query: 1525 RTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFG 1584
              G  C  +D CA   +     CVN  G Y C C   F LNP    C   ++  C     
Sbjct: 313  EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC--TKIDYC----- 365

Query: 1585 PRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN----------------STE 1628
                 +  C  E        SC C  G       +TC  +N                   
Sbjct: 366  --ASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEES 423

Query: 1629 YYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTR 1688
            YY  C  G    PN  T     +D C +    C+   C+NT  SF C+C +G+ ++ED +
Sbjct: 424  YYCRCHRGYTLDPNGKT--CSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLK 480

Query: 1689 ICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTT 1748
             C  +D C      C   +C N   ++ C CP  ++  + G  C  +    C    +G  
Sbjct: 481  TCSRVDYCLLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDGKTCAKL--DSCALGDHG-- 535

Query: 1749 CENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVD 1808
            CE+    +    +C C                               G+           
Sbjct: 536  CEHSCVSSEDSFVCQC-----------------------------FEGYILREDGKTCRR 566

Query: 1809 IDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCI 1868
             D C+ I   C + +C+N   S+ CEC  GF   +    C   D C +  + C+    C+
Sbjct: 567  KDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH--ICV 623

Query: 1869 NSPGSYRCECAAGFKLSPNG 1888
            N+  SY C+C+ GF L+ +G
Sbjct: 624  NNGNSYICKCSEGFVLAEDG 643



 Score =  155 bits (392), Expect = 6e-37
 Identities = 127/466 (27%), Positives = 176/466 (37%), Gaps = 79/466 (16%)

Query: 1506 CNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLN 1565
            C N+PG + C C  GY L+     C   D CA   +    LCVN PG + C C   + L 
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312

Query: 1566 PTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN 1625
              G  CV                                  C S      + C     VN
Sbjct: 313  EDGKRCV------------------------------AVDYCASENHGCEHEC-----VN 337

Query: 1626 STEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSE 1685
            +   Y LC   EGF  NP       ID C      CQ   C+NT  S+ C C +G+ L+ 
Sbjct: 338  ADGSY-LCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNP 395

Query: 1686 DTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYN 1745
            D + C  I+ C  +   C    C N   +Y C C   Y     G  C   R   C +  +
Sbjct: 396  DKKTCRRINYCALNKPGC-EHECVNMEESYYCRCHRGYTLDPNGKTCS--RVDHCAQQDH 452

Query: 1746 GTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGK 1805
            G  CE         ++C  T +                      +C    GF  +     
Sbjct: 453  G--CE---------QLCLNTED--------------------SFVCQCSEGFLINEDLKT 481

Query: 1806 AVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNA 1865
               +D C      C    C+N   SF C+CP G         C  +D C+ GD+ C+ + 
Sbjct: 482  CSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS- 539

Query: 1866 DCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFK 1924
             C++S  S+ C+C  G+ L  +G  C  ++ C  I + C H +CV+   SY C C  GF+
Sbjct: 540  -CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFR 597

Query: 1925 ASQDQTMCMDVDECE--RHPCGNGTCKNTVGSYNCLCYPGFELTHN 1968
             ++D   C   D C+   H C +  C N   SY C C  GF L  +
Sbjct: 598  LAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAED 642



 Score =  151 bits (382), Expect = 8e-36
 Identities = 127/478 (26%), Positives = 184/478 (38%), Gaps = 86/478 (17%)

Query: 779  CANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCP 838
            CA+  C N+ GSY C C  GY  ++    C   D C +    C+  LC N PGS+ C C 
Sbjct: 249  CAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCY 306

Query: 839  PGYVFRTETETCEDINECES-NPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGT 897
             GY    + + C  ++ C S N      C N  GS+ C+C  G  L+          K T
Sbjct: 307  SGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPD--------KKT 358

Query: 898  CWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVT----- 952
            C                  K + CA+        C   +   +C      +KG T     
Sbjct: 359  C-----------------TKIDYCASSNHGCQHECVNTDDSYSCHC----LKGFTLNPDK 397

Query: 953  --CEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDED 1010
              C  +N C +    C +  CVN + S++C C  G TLD  G+ C  +           D
Sbjct: 398  KTCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRV-----------D 445

Query: 1011 ECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPF 1070
             C     G    +  C     ++  +C E                 GF    D+ T    
Sbjct: 446  HCAQQDHG---CEQLCLNTEDSFVCQCSE-----------------GFLINEDLKT---- 481

Query: 1071 YKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGI 1130
               ++ C      C Y  C N   SF C+C  G  L  + + C  +D C +    C    
Sbjct: 482  CSRVDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS- 539

Query: 1131 CVNTPGSFECECFEGY---ESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPL 1187
            CV++  SF C+CFEGY   E G    K C   D C+     C    CVN++ S+ C+C  
Sbjct: 540  CVSSEDSFVCQCFEGYILREDG----KTCRRKDVCQAIDHGCE-HICVNSDDSYTCECLE 594

Query: 1188 GHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDE 1245
            G  L+   + C   + C  + + C +  CVN   +Y C C+ G+    D + C    E
Sbjct: 595  GFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651



 Score =  138 bits (348), Expect = 7e-32
 Identities = 88/298 (29%), Positives = 124/298 (41%), Gaps = 22/298 (7%)

Query: 495 IDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGD-CIDVDECTSN-PCTNGDCVNT 552
           ID C    + C +  C+ T  SY C C  G+  + +   C  ++ C  N P    +CVN 
Sbjct: 362 IDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 420

Query: 553 PGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDG 612
             SYYC+CH G+   P  + C  +D C Q    C+   C+NT+ SF C C+ GF +  D 
Sbjct: 421 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDL 479

Query: 613 KNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGH 672
           K C   D C  ++      C+N D SF C C  G VL  +G+ C  +D C          
Sbjct: 480 KTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS 539

Query: 673 CINSEGSFRCDCPPGLAVGMDGRVC--------VDTHMRSTCYGGIKKGVC--VRPFPGA 722
           C++SE SF C C  G  +  DG+ C        +D      C        C  +  F  A
Sbjct: 540 CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLA 599

Query: 723 VTKSEC----CCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDP 776
                C     C +  +G    C+     N   +   CS G  +  DGR   +C   P
Sbjct: 600 EDGKRCRRKDVCKSTHHG----CEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653



 Score = 79.3 bits (194), Expect = 5e-14
 Identities = 77/311 (24%), Positives = 111/311 (35%), Gaps = 67/311 (21%)

Query: 87  NVCGSRFHSYCCPGWKTLPGGNQCI-VPICRNS------------------CGDGFCSRP 127
           NV GS F   C  G+     G +C+ V  C +                   C +GF   P
Sbjct: 296 NVPGS-FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNP 354

Query: 128 NMCTCSSGQISSTCGSKSIQQC-------SVRCMNGGTCADDHCQCQKGYIGTYCG--QP 178
           +  TC+     ++       +C       S  C+ G T   D   C++     YC   +P
Sbjct: 355 DKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRI---NYCALNKP 411

Query: 179 VCENGCQNGGRCIGPNRCACVYGFT-GPQCERDYRTGPCFTQVNN--QMCQGQLTGIVCT 235
            CE+ C N         C C  G+T  P  +   R   C  Q +   Q+C       VC 
Sbjct: 412 GCEHECVNMEESY---YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ 468

Query: 236 KTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINT 295
                                    C  GF+ N     C  VD C      C+  +C+N 
Sbjct: 469 -------------------------CSEGFLINEDLKTCSRVDYCLLSDHGCEY-SCVNM 502

Query: 296 VGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDG 355
             SF C+CP GH      + C  +D C++    CE   C ++  S+ C C  GY+   DG
Sbjct: 503 DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE-HSCVSSEDSFVCQCFEGYILREDG 561

Query: 356 SRCIDQRTGMC 366
             C  +R  +C
Sbjct: 562 KTC--RRKDVC 570



 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 49/166 (29%), Positives = 69/166 (41%), Gaps = 11/166 (6%)

Query: 233 VCTKTLC----CATIGRAWGHPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGIC 287
           V  K LC    C+T+     H C   P      C++G+I N     C+  D C      C
Sbjct: 231 VFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC 290

Query: 288 QGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPR 347
           +   C+N  GSF C+C +G+  +E  ++C  +D C+     CE  EC N  GSY C C  
Sbjct: 291 EQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHE 348

Query: 348 GYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
           G+  + D   C    T + +    N  C  E         C C  G
Sbjct: 349 GFALNPDKKTC----TKIDYCASSNHGCQHECVNTDDSYSCHCLKG 390



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 69/257 (26%), Positives = 88/257 (34%), Gaps = 49/257 (19%)

Query: 115 CRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGT- 173
           CR  C  G+   PN  TCS       C  +    C   C+N  T     CQC +G++   
Sbjct: 426 CR--CHRGYTLDPNGKTCSR---VDHCAQQD-HGCEQLCLN--TEDSFVCQCSEGFLINE 477

Query: 174 ---------YC--GQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNN 222
                    YC      CE  C N  R      C C  G                     
Sbjct: 478 DLKTCSRVDYCLLSDHGCEYSCVNMDRSFA---CQCPEGHVL------------------ 516

Query: 223 QMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ-PQPCRRGFIPNIRTGACQDVDECQ 281
                +  G  C K   CA       H C          C  G+I       C+  D CQ
Sbjct: 517 -----RSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571

Query: 282 AIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSY 341
           AI   C+   C+N+  S+ C C  G + +E  ++C   D C      CE   C N   SY
Sbjct: 572 AIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSY 629

Query: 342 FCVCPRGYVTSTDGSRC 358
            C C  G+V + DG RC
Sbjct: 630 ICKCSEGFVLAEDGRRC 646


>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
          Length = 1184

 Score =  266 bits (681), Expect = 2e-70
 Identities = 216/692 (31%), Positives = 283/692 (40%), Gaps = 113/692 (16%)

Query: 809  IDIDECL-VNRLLCDNGLCRNTPGSYSC-------TCPPGYVFRTETETC--EDINEC-- 856
            ID DECL +     ++ +CR T   + C       +C  G +   E ETC  ED + C  
Sbjct: 454  IDNDECLEIPESGTEDNVCR-TAQRHCCVSYLQEKSCMAGVLGAKEGETCGAEDNDSCGI 512

Query: 857  ----ESNPCVNGACRNNLGSFNCECSP--GSKLSSTGLICIDSLKGTCWLNIQDSRCEVN 910
                +   C     R      +CE +P  G   +   L C +   G   L + + R    
Sbjct: 513  SLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCE---GEEPLIVPEVRRPPE 569

Query: 911  INGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGR 970
               A  +       G    S     EL  + P           +D +EC + PG      
Sbjct: 570  PAAAPRRVSEAEMAGREALSLGTEAELPNSLPG----------DDQDECLLLPGELCQHL 619

Query: 971  CVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVG 1030
            C+N+ GS+HC C  G +L   GR C               E   P P   +  A      
Sbjct: 620  CINTVGSYHCACFPGFSLQDDGRTC-------------RPEGHPPQPEAPQEPALKSEFS 666

Query: 1031 -AAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKC 1089
              A  T     P+P T                          KD   CK          C
Sbjct: 667  QVASNTIPLPLPQPNT-------------------------CKDNGPCKQV--------C 693

Query: 1090 RNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGI-CVNTPGSFECECFEGYES 1148
                GS  C C  G+A+  +  +C DI+EC      C  G  CVNT GSF C      E 
Sbjct: 694  STVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEP 753

Query: 1149 GFMMMKN-CMDIDECERNPLLCRGG-TCVNTEGSFQCD----CPLGHELSPSREDCVDIN 1202
            G+ +    C D+DEC      C+ G  C NT+GSF C     C  G    P   +CVDIN
Sbjct: 754  GYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEG-NCVDIN 812

Query: 1203 ECSLSDNLCRNG-KCVNMIGTYQCSCNP-----GYQATPDRQGCTDIDECM--IMNGGCD 1254
            EC+     CR G  C+N +G+Y C  NP     GY A+ D   C D++EC   +   G  
Sbjct: 813  ECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEG 872

Query: 1255 TQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGF 1314
              C N  GSY C C  G+     GR C D++EC  +P       C N  G YRC C  GF
Sbjct: 873  QVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGF 932

Query: 1315 MASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIG 1374
            + + D K C DVNEC+         EC N  GS+ C+C+ GY + +    CTD+DEC  G
Sbjct: 933  LLAADGKRCEDVNECEAQR---CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQG 989

Query: 1375 AH-NCDMHASCLNIPGSFKCSCRE---GWIGNGIKCIDLDECSNGTHQCSINAQCVNTPG 1430
            A   C     CLN+PGS++C+C E       NG  C D+DEC+ GTH CS    C N  G
Sbjct: 990  AGILCTFR--CLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQG 1047

Query: 1431 SYRC---ACSEGFTG------DGFTCSDVDEC 1453
            S+RC    C   +        +  TC D  EC
Sbjct: 1048 SFRCLRFECPPNYVQVSKTKCERTTCHDFLEC 1079



 Score =  266 bits (679), Expect = 3e-70
 Identities = 196/627 (31%), Positives = 270/627 (43%), Gaps = 111/627 (17%)

Query: 1026 CCAVGAAWGTECEEC---PKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPG 1082
            CCA G  W  + +EC   P+ GT++                           N C+    
Sbjct: 445  CCAAGQQWAIDNDECLEIPESGTED---------------------------NVCRTAQR 477

Query: 1083 MCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISP-----DLCGSGICVNTPG- 1136
             C    C + +    C      A + E     D D C IS      D CG G+ V   G 
Sbjct: 478  HC----CVSYLQEKSCMAGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQ 533

Query: 1137 SFECECFEGYESGFMMMKNC-----MDIDECERNPLLCRGGTCVN-TEGSFQCDCPLGHE 1190
            S E     GY    +M+  C     + + E  R P        V+  E + +    LG E
Sbjct: 534  SCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTE 593

Query: 1191 LS-PSREDCVDINECSL-SDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGC-------- 1240
               P+     D +EC L    LC++  C+N +G+Y C+C PG+    D + C        
Sbjct: 594  AELPNSLPGDDQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQ 652

Query: 1241 -------------TDIDECMIM-----------NGGCDTQCTNSEGSYECSCSEGYALMP 1276
                         + +    I            NG C   C+   GS  CSC  GYA+M 
Sbjct: 653  PEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMA 712

Query: 1277 DGRSCADIDECENNPDICDGGQ-CTNIPGEYRC----LCYDGFMASMDMKTCIDVNECDL 1331
            DG SC DI+EC  +   C  G+ C N  G + C     C  G+  ++    C DV+EC +
Sbjct: 713  DGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY--ALKDGECEDVDECAM 770

Query: 1332 NSNICMFG-ECENTKGSFIC----HCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLN 1386
             ++ C  G  C+NTKGSF C     C  G+ ++     C D++EC   +  C    SC+N
Sbjct: 771  GTHTCQPGFLCQNTKGSFYCQARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFSCIN 829

Query: 1387 IPGSFKCS-----CREGW--IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEG 1439
              GS+ C      C  G+    +G KC+D++EC  G H+C     C N PGSYRC C  G
Sbjct: 830  TVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAG 889

Query: 1440 FTGDGF--TCSDVDEC-AENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECS 1496
            F  D F   C DV+EC A    LC++  C N  G+YRC C  GF  A+D + C+D++EC 
Sbjct: 890  FQRDAFGRGCIDVNECWASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRCEDVNECE 948

Query: 1497 FQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCV-NGLCVNTPGRYE 1555
             Q       C N+ G + C C  GY+L   G  CTDIDECA     +    C+N PG Y+
Sbjct: 949  AQRCS--QECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQ 1006

Query: 1556 CNCPPD-FQLNPTGVGCVDNRVGNCYL 1581
            C CP   + +   G  C D  V  C L
Sbjct: 1007 CACPEQGYTMTANGRSCKD--VDECAL 1031



 Score =  263 bits (672), Expect = 2e-69
 Identities = 175/540 (32%), Positives = 244/540 (45%), Gaps = 56/540 (10%)

Query: 1594 NTEIGVGVSRSSC-CCSLG---KAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILE 1649
            N   G+ + +  C CC LG   +A G  CE+ P +     + +    EG  P  +  +  
Sbjct: 507  NDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRR 566

Query: 1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCY 1709
              +       + +         S   E      L  D     D DEC   PG      C 
Sbjct: 567  PPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGD-----DQDECLLLPGELCQHLCI 621

Query: 1710 NTLGNYTCICPPEYMQVNGGHNCM--------DMRKSFCYRSYNGTTCENELPFNVTKRM 1761
            NT+G+Y C C P +   + G  C         +  +    +S       N +P  + +  
Sbjct: 622  NTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPN 681

Query: 1762 CCCTYNVGKAWNKPC-EPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICA 1820
             C         N PC + C T G +    IC   PG+          DI+EC      C+
Sbjct: 682  TCKD-------NGPCKQVCSTVGGS---AICSCFPGYAIMADGVSCEDINECVTDLHTCS 731

Query: 1821 NGV-CINQIGSFRC----ECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYR 1875
             G  C+N +GSF C     C  G++  D    CED+DEC+ G + CQ    C N+ GS+ 
Sbjct: 732  RGEHCVNTLGSFHCYKALTCEPGYALKD--GECEDVDECAMGTHTCQPGFLCQNTKGSFY 789

Query: 1876 CE----CAAGFKLSPNGACVDRNECLEIPNVCSHGL-CVDLQGSYQC-----ICHNGFKA 1925
            C+    C  GF   P G CVD NEC  +   C  G  C++  GSY C     IC  G+ A
Sbjct: 790  CQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHA 849

Query: 1926 SQDQTMCMDVDECER--HPCGNG-TCKNTVGSYNCLCYPGFEL-THNNDCLDIDECSSFF 1981
            S D T C+DV+ECE   H CG G  C N  GSY C C  GF+       C+D++EC +  
Sbjct: 850  SDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASP 909

Query: 1982 GQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRC 2041
            G++C++  C N +GS++C C  G+ L  DGK C D NEC A    CS   C N+ GS++C
Sbjct: 910  GRLCQH-TCENTLGSYRCSCASGFLLAADGKRCEDVNECEA--QRCSQ-ECANIYGSYQC 965

Query: 2042 ICPPGYEVKSE--NCIDINECDEDPNICLFGSCTNTPGGFQCLCP-PGFVLSDNGRRCFD 2098
             C  GY++  +   C DI+EC +   I     C N PG +QC CP  G+ ++ NGR C D
Sbjct: 966  YCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD 1025



 Score =  255 bits (651), Expect = 5e-67
 Identities = 177/522 (33%), Positives = 240/522 (45%), Gaps = 68/522 (13%)

Query: 2170 EDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCT 2229
            +D +ECL  PG      CINT GS+ C C  G++L   G  C                  
Sbjct: 603  DDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 2230 NVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQ 2289
            +       N      P P   C+D   C Q        C    GS  C+C  GYA+  D 
Sbjct: 663  SEFSQVASNTIPLPLPQPN-TCKDNGPCKQV-------CSTVGGSAICSCFPGYAIMADG 714

Query: 2290 KMCKDLDECAEGLHDCESRGMMCKNLIGTFMC----ICPPGMARRPDGEGCVDENECRTK 2345
              C+D++EC   LH C SRG  C N +G+F C     C PG A + DGE C D +EC   
Sbjct: 715  VSCEDINECVTDLHTC-SRGEHCVNTLGSFHCYKALTCEPGYALK-DGE-CEDVDECAMG 771

Query: 2346 PGICENG-RCVNIIGSYRCE----CNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASS 2400
               C+ G  C N  GS+ C+    C +GF     G  C+D  +    +E     C+   S
Sbjct: 772  THTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEP----CRPGFS 826

Query: 2401 SRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR---DIDECKVMP 2457
              N V              + C+  PL        IC  G   + DG    D++EC+   
Sbjct: 827  CINTV------------GSYTCQRNPL--------ICARGYHASDDGTKCVDVNECETGV 866

Query: 2458 NLCTNGQ-CINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSP-KPCNYICKNTEGSYQC 2515
            + C  GQ C N  GS+RC CK G+  D  G  CID++EC  SP + C + C+NT GSY+C
Sbjct: 867  HRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRC 926

Query: 2516 SCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGF--TQHHTACIDNN 2573
            SC  G++L  DGK C+D++EC+ ++  C   C N  G + C C  G+   +    C D +
Sbjct: 927  SCASGFLLAADGKRCEDVNECEAQR--CSQECANIYGSYQCYCRQGYQLAEDGHTCTDID 984

Query: 2574 ECGSQPS-LCGAKGICQNTPGSFSCEC-QRGFSLDATGLNCEDVDECD-GNHRCQHG--C 2628
            EC      LC  +  C N PGS+ C C ++G+++ A G +C+DVDEC  G H C     C
Sbjct: 985  ECAQGAGILCTFR--CLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETC 1042

Query: 2629 QNILGGYRC---GCPQGYIQ----HYQWNQCVDENECSNPNA 2663
             NI G +RC    CP  Y+Q      +   C D  EC N  A
Sbjct: 1043 HNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSPA 1084



 Score =  246 bits (628), Expect = 2e-64
 Identities = 175/585 (29%), Positives = 255/585 (43%), Gaps = 80/585 (13%)

Query: 2338 DENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNR-----QGLCFAEVLQ 2392
            D++EC   PG      C+N +GSY C C  GF     G  C         +      +  
Sbjct: 604  DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663

Query: 2393 TICQMASSSRNL-VTKSECCCDGGRGWGHQC-ELCPLPGTAQYKKICPHGPGYT--TDG- 2447
               Q+AS++  L + +   C D G      C ++C   G +    IC   PGY    DG 
Sbjct: 664  EFSQVASNTIPLPLPQPNTCKDNG-----PCKQVCSTVGGSA---ICSCFPGYAIMADGV 715

Query: 2448 --RDIDECKVMPNLCTNGQ-CINTMGSFRCF----CKVGYTTDISGTSCIDLDECSQSPK 2500
               DI+EC    + C+ G+ C+NT+GSF C+    C+ GY   +    C D+DEC+    
Sbjct: 716  SCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYA--LKDGECEDVDECAMGTH 773

Query: 2501 PCN--YICKNTEGSYQCS----CPRGYVLQEDGKTCKDLDECQTKQHNCQ--FLCVNTLG 2552
             C   ++C+NT+GS+ C     C  G++   +G  C D++EC +    C+  F C+NT+G
Sbjct: 774  TCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN-CVDINECTSLSEPCRPGFSCINTVG 832

Query: 2553 GFTCK-----CPPGF--TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSL 2605
             +TC+     C  G+  +   T C+D NEC +    CG   +C N PGS+ C+C+ GF  
Sbjct: 833  SYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQR 892

Query: 2606 DATGLNCEDVDEC--DGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNA 2663
            DA G  C DV+EC       CQH C+N LG YRC C  G++      +C D NEC     
Sbjct: 893  DAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRC 952

Query: 2664 CGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKN-PCNYGCSNTEGGYLCGCP 2722
              S  C N  GSY+C C  G+   +    C D++EC+      C + C N  G Y C CP
Sbjct: 953  --SQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACP 1010

Query: 2723 -PGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEACYECKINGYSKKDSRQKRSI 2781
              GY     G     +               +E AL    C E +     +   R  R  
Sbjct: 1011 EQGYTMTANGRSCKDV---------------DECALGTHNCSEAETCHNIQGSFRCLRFE 1055

Query: 2782 HEPDPTAVEQISLESV---DMDSPVNMKFNLSH--------LGSKEHILELRPAIQPLNN 2830
              P+   V +   E     D     N    ++H        L    HI  + PA     +
Sbjct: 1056 CPPNYVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQTGLLVPAHIFRIGPAPAFTGD 1115

Query: 2831 HIRYVISQGNDDSVF---RIHQRNGLSYLHTAKKKLMPGTYTLEI 2872
             I   I +GN++  F   R++   G+ YL  A   L P  + L++
Sbjct: 1116 TIALNIIKGNEEGYFGTRRLNAYTGVVYLQRA--VLEPRDFALDV 1158



 Score =  235 bits (600), Expect = 4e-61
 Identities = 165/517 (31%), Positives = 224/517 (43%), Gaps = 100/517 (19%)

Query: 1808 DIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVC------------------- 1848
            D DEC  +PG     +CIN +GS+ C C  GFS  D    C                   
Sbjct: 604  DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663

Query: 1849 EDIDECSN-------GDNLCQRNAD----CINSPGSYRCECAAGFKLSPNG-ACVDRNEC 1896
            E     SN         N C+ N      C    GS  C C  G+ +  +G +C D NEC
Sbjct: 664  EFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINEC 723

Query: 1897 LEIPNVCSHG-LCVDLQGSYQC----ICHNGFKASQDQTMCMDVDECE--RHPCGNG-TC 1948
            +   + CS G  CV+  GS+ C     C  G+     +  C DVDEC    H C  G  C
Sbjct: 724  VTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE--CEDVDECAMGTHTCQPGFLC 781

Query: 1949 KNTVGSYNC----LCYPGFELTHNNDCLDIDECSSFFGQVCRNG-RCFNEIGSFKC---- 1999
            +NT GS+ C     C  GF      +C+DI+EC+S   + CR G  C N +GS+ C    
Sbjct: 782  QNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTS-LSEPCRPGFSCINTVGSYTCQRNP 840

Query: 2000 -LCNEGYELTPDGKNCIDTNECVALPGSCSPG-TCQNLEGSFRCICPPGY--EVKSENCI 2055
             +C  GY  + DG  C+D NEC      C  G  C NL GS+RC C  G+  +     CI
Sbjct: 841  LICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI 900

Query: 2056 DINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSV 2115
            D+NEC   P      +C NT G ++C C  GF+L+ +G+RC D  +       E  +CS 
Sbjct: 901  DVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNEC------EAQRCSQ 954

Query: 2116 PKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNEC 2175
                        C+ + G                ++Q  C  G+      H T  D++EC
Sbjct: 955  E-----------CANIYG----------------SYQCYCRQGYQLAEDGH-TCTDIDEC 986

Query: 2176 LESPGICSNGQCINTDGSFRCECP-MGYNLDYTGVRCVDTDECSIG-NPCGNG-TCTNVI 2232
             +  GI    +C+N  GS++C CP  GY +   G  C D DEC++G + C    TC N+ 
Sbjct: 987  AQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQ 1046

Query: 2233 GSFEC---NCNEGFEPGPMMNCE-----DINECAQNP 2261
            GSF C    C   +       CE     D  EC  +P
Sbjct: 1047 GSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSP 1083



 Score =  211 bits (537), Expect = 8e-54
 Identities = 159/538 (29%), Positives = 225/538 (41%), Gaps = 114/538 (21%)

Query: 810  DIDECLV-NRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCE----------------- 851
            D DECL+    LC + LC NT GSY C C PG+  + +  TC                  
Sbjct: 604  DQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 852  ----------------DINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLK 895
                              N C+ N      C    GS  C C PG  + + G+ C D   
Sbjct: 663  SEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDI-- 720

Query: 896  GTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCED 955
                     + C  +++  +    C  TLG+        C     C  G A +K   CED
Sbjct: 721  ---------NECVTDLHTCSRGEHCVNTLGSF------HCYKALTCEPGYA-LKDGECED 764

Query: 956  VNECEVFPGVC-PNGRCVNSKGSFHCE----CPEGLTLDGTGRVCLDIRMEQCYLKWDED 1010
            V+EC +    C P   C N+KGSF+C+    C +G   D  G  C+DI           +
Sbjct: 765  VDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN-CVDI-----------N 812

Query: 1011 ECI---HPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTG 1067
            EC     P    F   +C   VG+     C+  P         +C RG   ++ G     
Sbjct: 813  ECTSLSEPCRPGF---SCINTVGS---YTCQRNP--------LICARGYHASDDGTKCV- 857

Query: 1068 RPFYKDINECKAFPGMCTYGK-CRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLC 1126
                 D+NEC+     C  G+ C N  GS++C C +GF  D   R C D++EC  SP   
Sbjct: 858  -----DVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRL 912

Query: 1127 GSGICVNTPGSFECECFEGYESGFMMM---KNCMDIDECERNPLLCRGGTCVNTEGSFQC 1183
                C NT GS+ C C     SGF++    K C D++ECE          C N  GS+QC
Sbjct: 913  CQHTCENTLGSYRCSC----ASGFLLAADGKRCEDVNECEAQRC---SQECANIYGSYQC 965

Query: 1184 DCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSC-NPGYQATPDRQGCTD 1242
             C  G++L+     C DI+EC+    +    +C+N+ G+YQC+C   GY  T + + C D
Sbjct: 966  YCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD 1025

Query: 1243 IDECMIMNGGCD--TQCTNSEGSYEC---SCSEGYALMP----DGRSCADIDECENNP 1291
            +DEC +    C     C N +GS+ C    C   Y  +     +  +C D  EC+N+P
Sbjct: 1026 VDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSP 1083



 Score =  202 bits (513), Expect = 5e-51
 Identities = 141/423 (33%), Positives = 194/423 (45%), Gaps = 68/423 (16%)

Query: 471  VGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGR-CIPTVSSYRC----ECNMGY 525
            VGG+ + +   G  I    +  + I+ C    + C  G  C+ T+ S+ C     C  GY
Sbjct: 696  VGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY 755

Query: 526  KQDANGDCIDVDECT--SNPCTNGD-CVNTPGSYYC----KCHAGFQRTPTKQACIDIDE 578
                +G+C DVDEC   ++ C  G  C NT GS+YC    +C  GF + P    C+DI+E
Sbjct: 756  ALK-DGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN-CVDINE 813

Query: 579  CIQNGVLCKNG-RCVNTDGSFQC-----ICNAGFELTTDGKNCVDHDECTT-TNMCLNG- 630
            C      C+ G  C+NT GS+ C     IC  G+  + DG  CVD +EC T  + C  G 
Sbjct: 814  CTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQ 873

Query: 631  MCINEDGSFKCICKPGFVLAPNGRYCTDVDEC-QTPGICMNGHCINSEGSFRCDCPPGLA 689
            +C N  GS++C CK GF     GR C DV+EC  +PG      C N+ GS+RC C  G  
Sbjct: 874  VCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFL 933

Query: 690  VGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNS 749
            +  DG+ C D +                         EC          + C    A   
Sbjct: 934  LAADGKRCEDVN-------------------------EC--------EAQRCSQECANIY 960

Query: 750  AEFHGLCSSGVGITVDGR---DINECALDPDICANGICENLRGSYRCNC-NSGYEPDASG 805
              +   C  G  +  DG    DI+ECA    I     C N+ GSY+C C   GY   A+G
Sbjct: 961  GSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANG 1020

Query: 806  RNCIDIDECLVNRLLCDNG-LCRNTPGSYSCT---CPPGYVFRTETE----TCEDINECE 857
            R+C D+DEC +    C     C N  GS+ C    CPP YV  ++T+    TC D  EC+
Sbjct: 1021 RSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQ 1080

Query: 858  SNP 860
            ++P
Sbjct: 1081 NSP 1083



 Score =  201 bits (511), Expect = 9e-51
 Identities = 169/618 (27%), Positives = 227/618 (36%), Gaps = 154/618 (24%)

Query: 2276 ECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI-------CPPGMA 2328
            E  C  G     D   C ++ E     + C +    C        C+       C  G+ 
Sbjct: 443  ETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHC--------CVSYLQEKSCMAGVL 494

Query: 2329 RRPDGEGC--VDENECRTKPGICENGRCVNIIG--------SYRCECNE--GFQSSSSGT 2376
               +GE C   D + C    GI    +C +  G           CE N   G+  +    
Sbjct: 495  GAKEGETCGAEDNDSC----GISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVML 550

Query: 2377 ECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKI 2436
             C +  + L   EV +     A+  R  V+++E         G + EL            
Sbjct: 551  SCCEGEEPLIVPEVRRPPEPAAAPRR--VSEAEMAGREALSLGTEAEL------------ 596

Query: 2437 CPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSC-----ID 2491
             P+    +  G D DEC ++P       CINT+GS+ C C  G++    G +C       
Sbjct: 597  -PN----SLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPP 651

Query: 2492 LDECSQSPK---------------------------PCNYICKNTEGSYQCSCPRGYVLQ 2524
              E  Q P                            PC  +C    GS  CSC  GY + 
Sbjct: 652  QPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIM 711

Query: 2525 EDGKTCKDLDECQTKQHNCQ--FLCVNTLGGFTC----KCPPGFTQHHTACIDNNECGSQ 2578
             DG +C+D++EC T  H C     CVNTLG F C     C PG+      C D +EC   
Sbjct: 712  ADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMG 771

Query: 2579 PSLCGAKGICQNTPGSFSCE---------------------------------------- 2598
               C    +CQNT GSF C+                                        
Sbjct: 772  THTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTV 831

Query: 2599 -----------CQRGFSLDATGLNCEDVDECD-GNHRCQHG--CQNILGGYRCGCPQGYI 2644
                       C RG+     G  C DV+EC+ G HRC  G  C N+ G YRC C  G+ 
Sbjct: 832  GSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQ 891

Query: 2645 QHYQWNQCVDENEC-SNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSK 2703
            +      C+D NEC ++P      +C NTLGSY+C+C SGF        C DVNEC + +
Sbjct: 892  RDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR 951

Query: 2704 NPCNYGCSNTEGGYLCGCPPGYYRVGQGH-------CVSGMGFNKGQYLSLDTEVDEENA 2756
              C+  C+N  G Y C C  GY     GH       C  G G     +  L+     + A
Sbjct: 952  --CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGI-LCTFRCLNVPGSYQCA 1008

Query: 2757 LSPEACYECKINGYSKKD 2774
              PE  Y    NG S KD
Sbjct: 1009 -CPEQGYTMTANGRSCKD 1025



 Score =  200 bits (508), Expect = 2e-50
 Identities = 177/646 (27%), Positives = 245/646 (37%), Gaps = 142/646 (21%)

Query: 1176 NTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGK---CVNMIGTYQCSCNPGYQ 1232
            +T+   +  C  G + +   ++C++I E    DN+CR  +   CV+ +    C       
Sbjct: 437  STKDLIETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGA 496

Query: 1233 ATPDRQGCTDIDECMI-MNGGCDTQC--------------TNSEGSYEC-----SCSEGY 1272
               +  G  D D C I +   C   C              +N    Y C     SC EG 
Sbjct: 497  KEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGE 556

Query: 1273 -------------------------------------ALMPDGRSCADIDECENNPDICD 1295
                                                 A +P+     D DEC   P    
Sbjct: 557  EPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELC 616

Query: 1296 GGQCTNIPGEYRCLCYDGFMASMDMKTCIDVN---ECDLNSNICMFGECENTKGSFICHC 1352
               C N  G Y C C+ GF    D +TC       + +      +  E      + I   
Sbjct: 617  QHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTI--- 673

Query: 1353 QLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW--IGNGIKCIDLD 1410
                 + +  T C D   C+           C  + GS  CSC  G+  + +G+ C D++
Sbjct: 674  --PLPLPQPNT-CKDNGPCK---------QVCSTVGGSAICSCFPGYAIMADGVSCEDIN 721

Query: 1411 ECSNGTHQCSINAQCVNTPGSYRC----ACSEGFTGDGFTCSDVDECAENINLCENG-QC 1465
            EC    H CS    CVNT GS+ C     C  G+      C DVDECA   + C+ G  C
Sbjct: 722  ECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLC 781

Query: 1466 LNVPGAYRCE----CEMGFTPASDSRSCQDIDEC-SFQNICVFG-TCNNLPGMFHC---- 1515
             N  G++ C+    C  GF    +  +C DI+EC S    C  G +C N  G + C    
Sbjct: 782  QNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNP 840

Query: 1516 -ICDDGYELDRTGGNCTDIDECADPIN-CVNG-LCVNTPGRYECNCPPDFQLNPTGVGCV 1572
             IC  GY     G  C D++EC   ++ C  G +C N PG Y C+C   FQ +  G GC+
Sbjct: 841  LICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI 900

Query: 1573 DNRVGNCYLKFGPRGDGSLSCNT-EIGVGVSRSSCCCS-LGKAWGNPCETCPPVNSTEYY 1630
            D  V  C+        G L  +T E  +G  R SC    L  A G  CE           
Sbjct: 901  D--VNECWAS-----PGRLCQHTCENTLGSYRCSCASGFLLAADGKRCE----------- 942

Query: 1631 TLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRIC 1690
                               D++EC+     C    C N +GS+QC C QGY L+ED   C
Sbjct: 943  -------------------DVNECEAQR--CSQ-ECANIYGSYQCYCRQGYQLAEDGHTC 980

Query: 1691 EDIDECFAHPGVCGPGTCYNTLGNYTCICPPE-YMQVNGGHNCMDM 1735
             DIDEC    G+     C N  G+Y C CP + Y     G +C D+
Sbjct: 981  TDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDV 1026



 Score =  199 bits (505), Expect = 4e-50
 Identities = 206/731 (28%), Positives = 281/731 (38%), Gaps = 130/731 (17%)

Query: 246  AWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPA 305
            AW  P    P +PQ      +P+       D +   +IP     G+   T    E  C A
Sbjct: 397  AWIPPTREVPRKPQ-----VLPHSHVEEDTDPNSVHSIPRSSPEGS---TKDLIETCCAA 448

Query: 306  GHKQSETTQKCEDIDECSIIPGICETGE---CSNTVGSYFCVCPRGYVTSTDGSRCIDQR 362
            G + +    +C +I E      +C T +   C + +    C+   G + + +G  C  + 
Sbjct: 449  GQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMA--GVLGAKEGETCGAED 506

Query: 363  TGMCFSGLVN---GRCAQELPGRMTKMQC----------------CCEPGRCWGIGTI-- 401
               C   L       C   L  R     C                CCE      +  +  
Sbjct: 507  NDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRR 566

Query: 402  ---PEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGN----------G 448
               P A P R SE       + L +G       S PG          G           G
Sbjct: 567  PPEPAAAPRRVSEA-EMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQHLCINTVG 625

Query: 449  NGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITG--LTILNQTIDICKHHANLCL 506
            + +     GF     G    P  G        Q P +      + + TI +     N C 
Sbjct: 626  SYHCACFPGFSLQDDGRTCRPE-GHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCK 684

Query: 507  -NGRCIPTVS----SYRCECNMGYKQDANG-DCIDVDECTSN--PCTNGD-CVNTPGSYY 557
             NG C    S    S  C C  GY   A+G  C D++EC ++   C+ G+ CVNT GS++
Sbjct: 685  DNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFH 744

Query: 558  C----KCHAGFQRTPTKQACIDIDECIQNGVLCKNG-RCVNTDGSFQCI----CNAGFEL 608
            C     C  G+     +  C D+DEC      C+ G  C NT GSF C     C  GF  
Sbjct: 745  CYKALTCEPGYALKDGE--CEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQ 802

Query: 609  TTDGKNCVDHDECTT-TNMCLNGM-CINEDGSFKC-----ICKPGFVLAPNGRYCTDVDE 661
              +G NCVD +ECT+ +  C  G  CIN  GS+ C     IC  G+  + +G  C DV+E
Sbjct: 803  DPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNE 861

Query: 662  CQTPGI--CMNGH-CINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRP 718
            C+T G+  C  G  C N  GS+RCDC  G      GR C+D +                 
Sbjct: 862  CET-GVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNE---------------- 904

Query: 719  FPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGR---DINECALD 775
                      C A+P    G  CQ         +   C+SG  +  DG+   D+NEC  +
Sbjct: 905  ----------CWASP----GRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNEC--E 948

Query: 776  PDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSC 835
               C+   C N+ GSY+C C  GY+    G  C DIDEC     +     C N PGSY C
Sbjct: 949  AQRCSQE-CANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQC 1007

Query: 836  TCP-PGYVFRTETETCEDINECE--SNPCVNG-ACRNNLGSFNC---ECSPG----SKLS 884
             CP  GY       +C+D++EC   ++ C     C N  GSF C   EC P     SK  
Sbjct: 1008 ACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTK 1067

Query: 885  STGLICIDSLK 895
                 C D L+
Sbjct: 1068 CERTTCHDFLE 1078



 Score =  183 bits (465), Expect = 2e-45
 Identities = 189/699 (27%), Positives = 267/699 (38%), Gaps = 140/699 (20%)

Query: 1265 ECSCSEGYALMPDGRSCADIDECENNPDICDGGQ---CTNIPGEYRCLCYDGFMASMDMK 1321
            E  C+ G     D   C +I E     ++C   Q   C +   E  C+   G + + + +
Sbjct: 443  ETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMA--GVLGAKEGE 500

Query: 1322 TC--IDVNECDLN-----SNICMFGECENTKG-SFICHCQLGYSVKKGTTGCTDVDECEI 1373
            TC   D + C ++      + C  G     +G S   +  LGY        C + +E  I
Sbjct: 501  TCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLI 560

Query: 1374 GAH--------NCDMHASCLNIPGSFKCSC-REGWIGNGIKCIDLDECSNGTHQCSINAQ 1424
                             S   + G    S   E  + N +   D DEC     +   +  
Sbjct: 561  VPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQHL- 619

Query: 1425 CVNTPGSYRCACSEGFT--GDGFTC------------------SDVDECAENI------- 1457
            C+NT GSY CAC  GF+   DG TC                  S+  + A N        
Sbjct: 620  CINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQ 679

Query: 1458 -NLC-ENGQCLNV----PGAYRCECEMGFTPASDSRSCQDIDECSFQ-NICVFGT-CNNL 1509
             N C +NG C  V     G+  C C  G+   +D  SC+DI+EC    + C  G  C N 
Sbjct: 680  PNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNT 739

Query: 1510 PGMFHCI----CDDGYELDRTGGNCTDIDECADPIN-CVNG-LCVNTPGRYECN----CP 1559
             G FHC     C+ GY L    G C D+DECA   + C  G LC NT G + C     C 
Sbjct: 740  LGSFHCYKALTCEPGYALK--DGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCM 797

Query: 1560 PDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCE 1619
              F  +P G  CVD  +  C     P   G    NT       R+   C+ G        
Sbjct: 798  DGFLQDPEG-NCVD--INECTSLSEPCRPGFSCINTVGSYTCQRNPLICARG-------- 846

Query: 1620 TCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLC-QGGNCINTFGSFQCECP 1678
                 ++++  T C                D++EC+     C +G  C N  GS++C+C 
Sbjct: 847  ----YHASDDGTKCV---------------DVNECETGVHRCGEGQVCHNLPGSYRCDCK 887

Query: 1679 QGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKS 1738
             G+      R C D++EC+A PG     TC NTLG+Y C C   ++    G  C D+ + 
Sbjct: 888  AGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNEC 947

Query: 1739 FCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFT 1798
               R      C  E         C   Y                    ++  C       
Sbjct: 948  EAQR------CSQE---------CANIY------------------GSYQCYCRQGYQLA 974

Query: 1799 FDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECP-TGFSYNDLLLVCEDIDECSNG 1857
             D HT    DIDEC +  GI     C+N  GS++C CP  G++       C+D+DEC+ G
Sbjct: 975  EDGHT--CTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALG 1032

Query: 1858 DNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNEC 1896
             + C     C N  GS+RC     F+  PN   V + +C
Sbjct: 1033 THNCSEAETCHNIQGSFRC---LRFECPPNYVQVSKTKC 1068



 Score = 96.7 bits (239), Expect = 3e-19
 Identities = 94/386 (24%), Positives = 137/386 (35%), Gaps = 73/386 (18%)

Query: 25  GTAGQPQPPPPKPPRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLR 84
           G   +P+  PP+P  PQ P  +   +   S      P    +          +     + 
Sbjct: 641 GRTCRPEGHPPQPEAPQEPALKSEFSQVASN---TIPLPLPQPNTCKDNGPCKQVCSTVG 697

Query: 85  GPNVCGSRFHSYCCPGWKTLPGG------NQCIVPI--------CRNSCGDGFCSRPNMC 130
           G  +C       C PG+  +  G      N+C+  +        C N+ G   C +    
Sbjct: 698 GSAICS------CFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKA--L 749

Query: 131 TCSSGQISSTCGSKSIQQCSVRCMNGGTCADDH-CQCQKGYIGTYCGQPVCENGCQNG-G 188
           TC  G        + + +C+   M   TC     CQ  KG       Q   +   Q+  G
Sbjct: 750 TCEPGYALKDGECEDVDECA---MGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEG 806

Query: 189 RCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWG 248
            C+  N C  +             + PC              G  C  T+   T      
Sbjct: 807 NCVDINECTSL-------------SEPC------------RPGFSCINTVGSYT------ 835

Query: 249 HPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGIC-QGGNCINTVGSFECRCPAGH 307
                C   P  C RG+  +     C DV+EC+     C +G  C N  GS+ C C AG 
Sbjct: 836 -----CQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGF 890

Query: 308 KQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCF 367
           ++    + C D++EC   PG      C NT+GSY C C  G++ + DG RC D     C 
Sbjct: 891 QRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCED--VNECE 948

Query: 368 SGLVNGRCAQELPGRMTKMQCCCEPG 393
           +     RC+QE        QC C  G
Sbjct: 949 A----QRCSQECANIYGSYQCYCRQG 970



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 91/295 (30%), Positives = 116/295 (39%), Gaps = 60/295 (20%)

Query: 89   CGSRFHSYCCPGW--KTLPGGNQCIVPICRNSCGDGFCSRP-------NMCT-----CSS 134
            C    H+ C PG+  +   G   C     R  C DGF   P       N CT     C  
Sbjct: 768  CAMGTHT-CQPGFLCQNTKGSFYCQA---RQRCMDGFLQDPEGNCVDINECTSLSEPCRP 823

Query: 135  G-QISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENG---CQNGGRC 190
            G    +T GS + Q+  + C  G   +DD  +C             CE G   C  G  C
Sbjct: 824  GFSCINTVGSYTCQRNPLICARGYHASDDGTKC--------VDVNECETGVHRCGEGQVC 875

Query: 191  I---GPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAW 247
                G  RC C  GF     +RD     C   VN                 C A+ GR  
Sbjct: 876  HNLPGSYRCDCKAGF-----QRDAFGRGCI-DVNE----------------CWASPGRLC 913

Query: 248  GHPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAG 306
             H CE      +  C  GF+       C+DV+EC+A    C    C N  GS++C C  G
Sbjct: 914  QHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR--CSQ-ECANIYGSYQCYCRQG 970

Query: 307  HKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCP-RGYVTSTDGSRCID 360
            ++ +E    C DIDEC+   GI  T  C N  GSY C CP +GY  + +G  C D
Sbjct: 971  YQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD 1025



 Score = 59.7 bits (143), Expect = 4e-08
 Identities = 67/264 (25%), Positives = 94/264 (35%), Gaps = 59/264 (22%)

Query: 115  CRNSCGDGFCSRPNMCTCSSGQISSTCGSK--SIQQCSV---RCMNGGTC----ADDHCQ 165
            C N+ G   C R N   C+ G  +S  G+K   + +C     RC  G  C        C 
Sbjct: 827  CINTVGSYTCQR-NPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCD 885

Query: 166  CQKGY----IGTYC-------GQP--VCENGCQNGGRCIGPNRCACVYGFT--------- 203
            C+ G+     G  C         P  +C++ C+N    +G  RC+C  GF          
Sbjct: 886  CKAGFQRDAFGRGCIDVNECWASPGRLCQHTCEN---TLGSYRCSCASGFLLAADGKRCE 942

Query: 204  ----------GPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCAT-IGRAWGHPCE 252
                        +C   Y +  C+ +   Q+ +    G  CT    CA   G      C 
Sbjct: 943  DVNECEAQRCSQECANIYGSYQCYCRQGYQLAED---GHTCTDIDECAQGAGILCTFRCL 999

Query: 253  MCPAQPQPC--RRGFIPNIRTGACQDVDECQAIPGIC-QGGNCINTVGSFEC---RCPAG 306
              P   Q     +G+       +C+DVDEC      C +   C N  GSF C    CP  
Sbjct: 1000 NVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPN 1059

Query: 307  HKQSETTQ----KCEDIDECSIIP 326
            + Q   T+     C D  EC   P
Sbjct: 1060 YVQVSKTKCERTTCHDFLECQNSP 1083


>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
          Length = 988

 Score =  254 bits (648), Expect = 1e-66
 Identities = 151/423 (35%), Positives = 208/423 (49%), Gaps = 35/423 (8%)

Query: 1199 VDINECSLSDNLCR-NGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECM--IMNGGCDT 1255
            VD++ECS   + C  +  C N   +Y+C C PGY+   + + C DIDEC     NGGC  
Sbjct: 32   VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKG--EGKQCEDIDECENDYYNGGCVH 89

Query: 1256 QCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFM 1315
            +C N  G+Y C+C +G+ L  DG +C D+DEC++N   C    C N  G Y C C+ GF 
Sbjct: 90   ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFF 148

Query: 1316 ASMDMKTCIDVNECDLN--------SNICMFGECENTKGSFICHCQLGYSVKKGTTGCTD 1367
             S +  TCI  +   +N        ++IC     E  KG   C C+ G+ + +    CT 
Sbjct: 149  LSDNQHTCIHRSNEGMNCMNKDHGCAHICR----ETPKGGVACDCRPGFDLAQNQKDCTL 204

Query: 1368 VDECEIGAHNCDMHASCLNIPGSFKCSCREGWI--GNGIKCIDLDECSNGTHQCSINAQC 1425
               C  G   C    SC +      C C + +    +G  CI+    +NG      +  C
Sbjct: 205  T--CNYGNGGCQH--SCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNG----GCDRTC 256

Query: 1426 VNTPGSYRCACSEGFT--GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPA 1483
             +T    RC+C  GFT   DG TC D++EC  N   C++  C N  G++ C C  G+   
Sbjct: 257  KDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHF-CRNTVGSFECGCRKGYKLL 315

Query: 1484 SDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCV 1543
            +D R+CQDIDECSF+  C    C N PG F C+C  GY L  T  +C D+DEC+      
Sbjct: 316  TDERTCQDIDECSFERTCDH-ICINSPGSFQCLCHRGYILYGTT-HCGDVDECSMSNGSC 373

Query: 1544 NGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSR 1603
            +  CVNT G YEC CPP  +L+  G  CV+   G C  +        LSC+   GV    
Sbjct: 374  DQGCVNTKGSYECVCPPGRRLHWNGKDCVE--TGKCLSRAKTSPRAQLSCSKAGGVESCF 431

Query: 1604 SSC 1606
             SC
Sbjct: 432  LSC 434



 Score =  207 bits (526), Expect = 2e-52
 Identities = 144/427 (33%), Positives = 188/427 (44%), Gaps = 38/427 (8%)

Query: 1933 MDVDECER--HPCG-NGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSS-FFGQVCRNG 1988
            +DVDEC      C  +  C+NT  SY CLC PG++      C DIDEC + ++   C + 
Sbjct: 32   VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK-GEGKQCEDIDECENDYYNGGCVH- 89

Query: 1989 RCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYE 2048
             C N  G+++C C +G+ L  DG NC+D +EC    G C    C N  GS+ C C  G+ 
Sbjct: 90   ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFF 148

Query: 2049 VKSENCIDINECDEDPNICLFGS------CTNTP-GGFQCLCPPGFVLSDNGRRCFDTRQ 2101
            +       I+  +E  N C+         C  TP GG  C C PGF L+ N + C  T  
Sbjct: 149  LSDNQHTCIHRSNEGMN-CMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT-- 205

Query: 2102 SFCFTNFENGKCSVPKAFNTTKAKCCC-SKMPGEGWGDPC-ELCP----------KDDEV 2149
                 N+ NG C        T   C C  K      G  C E C           KD   
Sbjct: 206  ----CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTAT 261

Query: 2150 AFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGV 2209
              +  CP G    P    T +D+NECL + G C +  C NT GSF C C  GY L     
Sbjct: 262  GVRCSCPVGFTLQPD-GKTCKDINECLVNNGGCDHF-CRNTVGSFECGCRKGYKLLTDER 319

Query: 2210 RCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCM 2269
             C D DECS    C +  C N  GSF+C C+ G+      +C D++EC+ +   C   C+
Sbjct: 320  TCQDIDECSFERTCDH-ICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQGCV 378

Query: 2270 NTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI--CPPGM 2327
            NT GSYEC CP G  L  + K C +  +C           + C    G   C   CP   
Sbjct: 379  NTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCPAHT 438

Query: 2328 ARRPDGE 2334
               PD E
Sbjct: 439  LFVPDSE 445



 Score =  203 bits (517), Expect = 2e-51
 Identities = 132/418 (31%), Positives = 190/418 (45%), Gaps = 45/418 (10%)

Query: 2253 DINECAQNPLLCAFR--CMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGM 2310
            D++EC++    C     C NT  SY+C C  GY  + + K C+D+DEC    +D  + G 
Sbjct: 33   DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECE---NDYYNGGC 87

Query: 2311 M--CKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEG 2368
            +  C N+ G + C C  G     DG  C+D +EC+   G C+   CVN +GSY C+C+ G
Sbjct: 88   VHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSG 146

Query: 2369 F----------QSSSSGTECLDNRQGLCFAEVLQT-----ICQMASSSRNLVTKSEC--- 2410
            F            S+ G  C++   G C     +T      C           + +C   
Sbjct: 147  FFLSDNQHTCIHRSNEGMNCMNKDHG-CAHICRETPKGGVACDCRPGFDLAQNQKDCTLT 205

Query: 2411 CCDGGRGWGHQCELCPL-PGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTM 2469
            C  G  G  H CE     P    ++K   H  G T     I+ C V    C    C +T 
Sbjct: 206  CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC----IETCAVNNGGCDR-TCKDTA 260

Query: 2470 GSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKT 2529
               RC C VG+T    G +C D++EC  +   C++ C+NT GS++C C +GY L  D +T
Sbjct: 261  TGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERT 320

Query: 2530 CKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTA-CIDNNECGSQPSLCGAKGIC 2588
            C+D+DEC + +  C  +C+N+ G F C C  G+  + T  C D +EC      C     C
Sbjct: 321  CQDIDEC-SFERTCDHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQG--C 377

Query: 2589 QNTPGSFSCECQRGFSLDATGLNCEDVDEC----DGNHRCQHGCQNILGGYRC--GCP 2640
             NT GS+ C C  G  L   G +C +  +C      + R Q  C    G   C   CP
Sbjct: 378  VNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCP 435



 Score =  196 bits (498), Expect = 3e-49
 Identities = 118/342 (34%), Positives = 156/342 (45%), Gaps = 57/342 (16%)

Query: 2433 YKKICPHGPGYTTDGR---DIDECKVMPNLCTNG----QCINTMGSFRCFCKVGYTTDIS 2485
            YK +C   PGY  +G+   DIDEC+   N   NG    +CIN  G++RC C  G+     
Sbjct: 57   YKCLCK--PGYKGEGKQCEDIDECE---NDYYNGGCVHECINIPGNYRCTCFDGFMLAHD 111

Query: 2486 GTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTC----KDLDECQTKQH 2541
            G +C+D+DEC  +   C  IC N  GSY+C C  G+ L ++  TC     +   C  K H
Sbjct: 112  GHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDH 171

Query: 2542 NCQFLCVNT-LGGFTCKCPPGFT-------------------QHHTACIDNNE-CG---- 2576
             C  +C  T  GG  C C PGF                    QH     D    CG    
Sbjct: 172  GCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQK 231

Query: 2577 ----SQPSLC---------GAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC-DGNH 2622
                S    C         G    C++T     C C  GF+L   G  C+D++EC   N 
Sbjct: 232  YALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNG 291

Query: 2623 RCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPS 2682
             C H C+N +G + CGC +GY        C D +ECS    C    C N+ GS++C C  
Sbjct: 292  GCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHI-CINSPGSFQCLCHR 350

Query: 2683 GFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPG 2724
            G+     ++ C DV+ECS S   C+ GC NT+G Y C CPPG
Sbjct: 351  GYIL-YGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPG 391



 Score =  192 bits (489), Expect = 3e-48
 Identities = 103/288 (35%), Positives = 145/288 (50%), Gaps = 19/288 (6%)

Query: 2449 DIDECKVMPNLC-TNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQS--PKPCNYI 2505
            D+DEC    + C  +  C NT  S++C CK GY  +  G  C D+DEC        C + 
Sbjct: 33   DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGE--GKQCEDIDECENDYYNGGCVHE 90

Query: 2506 CKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGF--- 2562
            C N  G+Y+C+C  G++L  DG  C D+DECQ     CQ +CVN +G + C+C  GF   
Sbjct: 91   CINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLS 150

Query: 2563 TQHHTACIDNNE---CGSQPSLCGAKGICQNTP-GSFSCECQRGFSLDATGLNCEDVDEC 2618
               HT    +NE   C ++    G   IC+ TP G  +C+C+ GF L     +C     C
Sbjct: 151  DNQHTCIHRSNEGMNCMNKDH--GCAHICRETPKGGVACDCRPGFDLAQNQKDC--TLTC 206

Query: 2619 D-GNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYK 2677
            + GN  CQH C++   G  CGC Q Y  H     C++   C+  N     +C +T    +
Sbjct: 207  NYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE--TCAVNNGGCDRTCKDTATGVR 264

Query: 2678 CACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGY 2725
            C+CP GF+       C D+NEC  +   C++ C NT G + CGC  GY
Sbjct: 265  CSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGY 312



 Score =  191 bits (485), Expect = 9e-48
 Identities = 128/405 (31%), Positives = 179/405 (44%), Gaps = 53/405 (13%)

Query: 1361 GTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCS 1420
            G  G  DVDEC  G  +C + A C N P S+KC C+ G+ G G +C D+DEC N  +   
Sbjct: 27   GLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGG 86

Query: 1421 INAQCVNTPGSYRCACSEGF--TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEM 1478
               +C+N PG+YRC C +GF    DG  C DVDEC +N   C+   C+N  G+Y C+C  
Sbjct: 87   CVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHS 145

Query: 1479 GFTPASDSRSC----QDIDECSFQNICVFGTCNNLP-GMFHCICDDGYELDRTGGNCTDI 1533
            GF  + +  +C     +   C  ++      C   P G   C C  G++L +   +CT  
Sbjct: 146  GFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCT-- 203

Query: 1534 DECADPINCVNG------LCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRG 1587
                  + C  G       C +T     C C   + L+  G  C++    N        G
Sbjct: 204  ------LTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVN-------NG 250

Query: 1588 DGSLSC-NTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN--------------STEYYTL 1632
                +C +T  GV      C C +G       +TC  +N              +T     
Sbjct: 251  GCDRTCKDTATGV-----RCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFE 305

Query: 1633 CPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICED 1692
            C   +G++        +DIDEC      C    CIN+ GSFQC C +GY L   T  C D
Sbjct: 306  CGCRKGYKLLTDERTCQDIDEC-SFERTCD-HICINSPGSFQCLCHRGYILYGTTH-CGD 362

Query: 1693 IDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRK 1737
            +DEC    G C  G C NT G+Y C+CPP       G +C++  K
Sbjct: 363  VDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGK 406



 Score =  190 bits (483), Expect = 2e-47
 Identities = 134/393 (34%), Positives = 181/393 (46%), Gaps = 49/393 (12%)

Query: 534 IDVDECT--SNPC-TNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNG- 589
           +DVDEC+  ++ C  +  C NTP SY C C  G++    +  C DIDEC  +     NG 
Sbjct: 32  VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDIDECENDYY---NGG 86

Query: 590 ---RCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPG 646
               C+N  G+++C C  GF L  DG NC+D DEC   N     +C+N  GS++C C  G
Sbjct: 87  CVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSG 146

Query: 647 FVLAPNGRYCTDVDECQTPGICMN-----GHCINS--EGSFRCDCPPGLAVGMDGRVCVD 699
           F L+ N   C  +        CMN      H      +G   CDC PG  +  + + C  
Sbjct: 147 FFLSDNQHTC--IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCT- 203

Query: 700 THMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPD--YGFGEPC-QPCPAKNSA------ 750
                TC  G   G C        T   C C      +  G  C + C   N        
Sbjct: 204 ----LTCNYG--NGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCK 257

Query: 751 -EFHGL-CSSGVGITV--DG---RDINECALDPDICANGICENLRGSYRCNCNSGYEPDA 803
               G+ CS  VG T+  DG   +DINEC ++   C +  C N  GS+ C C  GY+   
Sbjct: 258 DTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC-DHFCRNTVGSFECGCRKGYKLLT 316

Query: 804 SGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECE-SNPCV 862
             R C DIDEC   R  CD+ +C N+PGS+ C C  GY+    T  C D++EC  SN   
Sbjct: 317 DERTCQDIDECSFER-TCDH-ICINSPGSFQCLCHRGYILYGTTH-CGDVDECSMSNGSC 373

Query: 863 NGACRNNLGSFNCECSPGSKLSSTGLICIDSLK 895
           +  C N  GS+ C C PG +L   G  C+++ K
Sbjct: 374 DQGCVNTKGSYECVCPPGRRLHWNGKDCVETGK 406



 Score =  189 bits (480), Expect = 3e-47
 Identities = 133/438 (30%), Positives = 187/438 (42%), Gaps = 80/438 (18%)

Query: 574 IDIDECIQNGVLCK-NGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMC 632
           +D+DEC +    C  +  C NT  S++C+C  G++   +GK C D DEC   N   NG C
Sbjct: 32  VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECE--NDYYNGGC 87

Query: 633 INE----DGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGL 688
           ++E     G+++C C  GF+LA +G  C DVDECQ         C+N+ GS+ C C  G 
Sbjct: 88  VHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGF 147

Query: 689 AVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKN 748
            +  +   C+                         +     C N D+G    C+  P   
Sbjct: 148 FLSDNQHTCIHR-----------------------SNEGMNCMNKDHGCAHICRETPKGG 184

Query: 749 SAEFHGLCSSGVGITVDGRDIN-ECALDPDICANGICENLRGSYRCNCNSGYEPDASGRN 807
            A     C  G  +  + +D    C      C +  CE+      C C+  Y   + GR 
Sbjct: 185 VACD---CRPGFDLAQNQKDCTLTCNYGNGGCQHS-CEDTDTGPTCGCHQKYALHSDGRT 240

Query: 808 CIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGAC- 866
           CI+   C VN   CD   C++T     C+CP G+  + + +TC+DINEC  N   NG C 
Sbjct: 241 CIET--CAVNNGGCDR-TCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVN---NGGCD 294

Query: 867 ---RNNLGSFNCECSPGSKLSSTGLICID----SLKGTCWLNIQDSRCEVNINGATLKSE 919
              RN +GSF C C  G KL +    C D    S + TC     D  C +N  G+     
Sbjct: 295 HFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTC-----DHIC-INSPGS----- 343

Query: 920 CCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFH 979
                                C RG        C DV+EC +  G C  G CVN+KGS+ 
Sbjct: 344 -----------------FQCLCHRGYILYGTTHCGDVDECSMSNGSCDQG-CVNTKGSYE 385

Query: 980 CECPEGLTLDGTGRVCLD 997
           C CP G  L   G+ C++
Sbjct: 386 CVCPPGRRLHWNGKDCVE 403



 Score =  187 bits (476), Expect = 1e-46
 Identities = 127/409 (31%), Positives = 187/409 (45%), Gaps = 82/409 (20%)

Query: 1016 VPGKFRMDACC-----CAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPF 1070
            +PG   +D C      C + A     C+  PK     Y+ LC    G+   G        
Sbjct: 28   LPGSVDVDECSEGTDDCHIDAI----CQNTPK----SYKCLCK--PGYKGEGKQC----- 72

Query: 1071 YKDINECKA--FPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGS 1128
             +DI+EC+   + G C + +C N  G+++C C  GF L  +  NC D+DEC+ +   C  
Sbjct: 73   -EDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ 130

Query: 1129 GICVNTPGSFECECFEGYESGFMMMKN-------------CMDIDE-----CERNP---- 1166
             ICVN  GS+EC+C     SGF +  N             CM+ D      C   P    
Sbjct: 131  -ICVNAMGSYECQC----HSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGV 185

Query: 1167 ------------------LLCRGG------TCVNTEGSFQCDCPLGHELSPSREDCVDIN 1202
                              L C  G      +C +T+    C C   + L      C++  
Sbjct: 186  ACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIET- 244

Query: 1203 ECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEG 1262
             C++++  C +  C +     +CSC  G+   PD + C DI+EC++ NGGCD  C N+ G
Sbjct: 245  -CAVNNGGC-DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVG 302

Query: 1263 SYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKT 1322
            S+EC C +GY L+ D R+C DIDEC +    CD   C N PG ++CLC+ G++       
Sbjct: 303  SFECGCRKGYKLLTDERTCQDIDEC-SFERTCD-HICINSPGSFQCLCHRGYIL-YGTTH 359

Query: 1323 CIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDEC 1371
            C DV+EC +++  C  G C NTKGS+ C C  G  +      C +  +C
Sbjct: 360  CGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407



 Score =  179 bits (455), Expect = 3e-44
 Identities = 133/443 (30%), Positives = 194/443 (43%), Gaps = 66/443 (14%)

Query: 471 VGGAGVGAGGQGPIITGLTILNQTIDICKHHANLC-LNGRCIPTVSSYRCECNMGYKQDA 529
           +G  G  AGG G  + G    +  +D C    + C ++  C  T  SY+C C  GYK + 
Sbjct: 16  LGTRGRLAGGSG--LPG----SVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEG 69

Query: 530 NGDCIDVDECTSNPCTNG---DCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLC 586
              C D+DEC ++    G   +C+N PG+Y C C  GF        C+D+DEC  N   C
Sbjct: 70  K-QCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC 128

Query: 587 KNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINED---------- 636
           +   CVN  GS++C C++GF L+ +   C+       +N  +N  C+N+D          
Sbjct: 129 QQ-ICVNAMGSYECQCHSGFFLSDNQHTCIHR-----SNEGMN--CMNKDHGCAHICRET 180

Query: 637 --GSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDG 694
             G   C C+PGF LA N + CT        G C +  C +++    C C    A+  DG
Sbjct: 181 PKGGVACDCRPGFDLAQNQKDCTLTCNYGNGG-CQHS-CEDTDTGPTCGCHQKYALHSDG 238

Query: 695 RVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCA-----NPDYGFGEPCQPCPAKNS 749
           R C++T     C   +  G C R      T   C C       PD    +    C   N 
Sbjct: 239 RTCIET-----C--AVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNG 291

Query: 750 A----------EFHGLCSSGVGITVDGR---DINECALDPDICANGICENLRGSYRCNCN 796
                       F   C  G  +  D R   DI+EC+ +     + IC N  GS++C C+
Sbjct: 292 GCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERT--CDHICINSPGSFQCLCH 349

Query: 797 SGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINEC 856
            GY    +  +C D+DEC ++   CD G C NT GSY C CPPG       + C +  +C
Sbjct: 350 RGYILYGT-THCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407

Query: 857 ----ESNPCVNGACRNNLGSFNC 875
               +++P    +C    G  +C
Sbjct: 408 LSRAKTSPRAQLSCSKAGGVESC 430



 Score =  178 bits (452), Expect = 6e-44
 Identities = 122/395 (30%), Positives = 174/395 (44%), Gaps = 40/395 (10%)

Query: 1650 DIDECQELPGLCQ-GGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFA--HPGVCGPG 1706
            D+DEC E    C     C NT  S++C C  GY    + + CEDIDEC    + G C   
Sbjct: 33   DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGC-VH 89

Query: 1707 TCYNTLGNYTCICPPEYMQVNGGHNCMDMRK---------SFCYRSYNGTTCENELPFNV 1757
             C N  GNY C C   +M  + GHNC+D+ +           C  +     C+    F +
Sbjct: 90   ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFL 149

Query: 1758 TKRMCCCTYNVGKAWN---------KPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVD 1808
            +     C +   +  N           C   P  G A     C   PGF  D+   +   
Sbjct: 150  SDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVA-----CDCRPGF--DLAQNQKDC 202

Query: 1809 IDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCI 1868
               C    G C +  C +      C C   ++ +     C  I+ C+  +  C R   C 
Sbjct: 203  TLTCNYGNGGCQHS-CEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRT--CK 257

Query: 1869 NSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQ 1927
            ++    RC C  GF L P+G  C D NECL     C H  C +  GS++C C  G+K   
Sbjct: 258  DTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDH-FCRNTVGSFECGCRKGYKLLT 316

Query: 1928 DQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRN 1987
            D+  C D+DEC      +  C N+ GS+ CLC+ G+ L     C D+DECS   G  C  
Sbjct: 317  DERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGS-CDQ 375

Query: 1988 GRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVA 2022
            G C N  GS++C+C  G  L  +GK+C++T +C++
Sbjct: 376  G-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLS 409



 Score =  170 bits (431), Expect = 2e-41
 Identities = 128/443 (28%), Positives = 169/443 (38%), Gaps = 92/443 (20%)

Query: 2335 GCVDENECRTKPGICE-NGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQT 2393
            G VD +EC      C  +  C N   SY+C C  G++      E +D             
Sbjct: 30   GSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDID------------- 76

Query: 2394 ICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR---DI 2450
                           EC  D   G G   E   +PG   Y+  C  G     DG    D+
Sbjct: 77   ---------------ECENDYYNG-GCVHECINIPGN--YRCTCFDGFMLAHDGHNCLDV 118

Query: 2451 DECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDIS----------GTSCIDLDE-----C 2495
            DEC+     C    C+N MGS+ C C  G+    +          G +C++ D      C
Sbjct: 119  DECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHIC 177

Query: 2496 SQSPK----------------------PCNY-------ICKNTEGSYQCSCPRGYVLQED 2526
             ++PK                       CNY        C++T+    C C + Y L  D
Sbjct: 178  RETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSD 237

Query: 2527 GKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTA--CIDNNECGSQPSLCGA 2584
            G+TC  ++ C      C   C +T  G  C CP GFT       C D NEC       G 
Sbjct: 238  GRTC--IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNG--GC 293

Query: 2585 KGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYI 2644
               C+NT GSF C C++G+ L      C+D+DEC     C H C N  G ++C C +GYI
Sbjct: 294  DHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYI 353

Query: 2645 QHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSS--- 2701
              Y    C D +ECS  N      C NT GSY+C CP G         C +  +C S   
Sbjct: 354  L-YGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAK 412

Query: 2702 SKNPCNYGCSNTEGGYLC--GCP 2722
            +       CS   G   C   CP
Sbjct: 413  TSPRAQLSCSKAGGVESCFLSCP 435



 Score =  142 bits (359), Expect = 4e-33
 Identities = 141/498 (28%), Positives = 190/498 (38%), Gaps = 118/498 (23%)

Query: 852  DINECE--SNPC-VNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCE 908
            D++EC   ++ C ++  C+N   S+ C C PG K    G  C D              CE
Sbjct: 33   DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDI-----------DECE 79

Query: 909  VNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPN 968
             +        EC    G        RC   T     +    G  C DV+EC+   G C  
Sbjct: 80   NDYYNGGCVHECINIPGNY------RC---TCFDGFMLAHDGHNCLDVDECQDNNGGCQQ 130

Query: 969  GRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIH-----PVPGKFRMD 1023
              CVN+ GS+ C+C  G  L      C+    E       +  C H     P  G     
Sbjct: 131  -ICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGV---- 185

Query: 1024 ACCCAVGAAWGTECEEC---------------------PKPGTKEYETL------CPRGA 1056
            AC C  G       ++C                     P  G  +   L      C    
Sbjct: 186  ACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETC 245

Query: 1057 GFANRG------DVLTG--------------RPFYKDINECKAFPGMCTYGKCRNTIGSF 1096
               N G      D  TG                  KDINEC    G C +  CRNT+GSF
Sbjct: 246  AVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDH-FCRNTVGSF 304

Query: 1097 KCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNC 1156
            +C C  G+ L  +ER C DIDEC  S +     IC+N+PGSF+C C  GY        +C
Sbjct: 305  ECGCRKGYKLLTDERTCQDIDEC--SFERTCDHICINSPGSFQCLCHRGYI--LYGTTHC 360

Query: 1157 MDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKC 1216
             D+DEC  +   C  G CVNT+GS++C CP G  L  + +DCV+             GKC
Sbjct: 361  GDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVE------------TGKC 407

Query: 1217 VNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCS----EGY 1272
            ++   T     +P  Q +  + G   ++ C +          +SE SY  SC     +G 
Sbjct: 408  LSRAKT-----SPRAQLSCSKAG--GVESCFLSCPAHTLFVPDSENSYVLSCGVPGPQGK 460

Query: 1273 ALMPD-------GRSCAD 1283
            AL          G SC+D
Sbjct: 461  ALQKRNGTSSGLGPSCSD 478



 Score = 92.0 bits (227), Expect = 7e-18
 Identities = 97/361 (26%), Positives = 133/361 (36%), Gaps = 71/361 (19%)

Query: 88  VCGSRFHSYCC---PGWKTLPGGNQCI-VPICRNSCGDGFCSRPNM-------CTCSSGQ 136
           +C +   SY C   PG+K    G QC  +  C N   +G C    +       CTC  G 
Sbjct: 49  ICQNTPKSYKCLCKPGYKG--EGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGF 106

Query: 137 ISSTCGSKSIQQCSVRCMNGGT---CADD----HCQCQKGYIGTYCGQPVCENGCQNGGR 189
           + +  G   +     +  NGG    C +      CQC  G+  +   Q  C +    G  
Sbjct: 107 MLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSD-NQHTCIHRSNEGMN 165

Query: 190 CIGPNR---------------CACVYGFTGPQCERD------YRTGPCFTQVNNQMCQGQ 228
           C+  +                C C  GF   Q ++D      Y  G C        C+  
Sbjct: 166 CMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGC-----QHSCEDT 220

Query: 229 LTGIVC-------------TKTLCCATIGRAWGHPCEMCPAQPQ-PCRRGFIPNIRTGAC 274
            TG  C             T    CA         C+      +  C  GF        C
Sbjct: 221 DTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTC 280

Query: 275 QDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGEC 334
           +D++EC    G C    C NTVGSFEC C  G+K     + C+DIDECS     C+   C
Sbjct: 281 KDINECLVNNGGCDHF-CRNTVGSFECGCRKGYKLLTDERTCQDIDECS-FERTCD-HIC 337

Query: 335 SNTVGSYFCVCPRGYVT-STDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
            N+ GS+ C+C RGY+   T     +D+        + NG C Q         +C C PG
Sbjct: 338 INSPGSFQCLCHRGYILYGTTHCGDVDE------CSMSNGSCDQGCVNTKGSYECVCPPG 391

Query: 394 R 394
           R
Sbjct: 392 R 392



 Score = 89.7 bits (221), Expect = 4e-17
 Identities = 82/274 (29%), Positives = 111/274 (40%), Gaps = 55/274 (20%)

Query: 97  CCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNG 156
           C PG+        C +     + G+G C      +C       TCG     Q      +G
Sbjct: 189 CRPGFDLAQNQKDCTLTC---NYGNGGCQH----SCEDTDTGPTCGC---HQKYALHSDG 238

Query: 157 GTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPC 216
            TC +  C    G          C+  C++    +   RC+C  GFT    + D +T   
Sbjct: 239 RTCIET-CAVNNGG---------CDRTCKDTATGV---RCSCPVGFT---LQPDGKTCKD 282

Query: 217 FTQ--VNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGAC 274
             +  VNN  C             C  T+G      C         CR+G+        C
Sbjct: 283 INECLVNNGGCDH----------FCRNTVG---SFECG--------CRKGYKLLTDERTC 321

Query: 275 QDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGEC 334
           QD+DEC +    C    CIN+ GSF+C C  G+    TT  C D+DECS+  G C+ G C
Sbjct: 322 QDIDEC-SFERTCDH-ICINSPGSFQCLCHRGYILYGTTH-CGDVDECSMSNGSCDQG-C 377

Query: 335 SNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFS 368
            NT GSY CVCP G     +G  C++  TG C S
Sbjct: 378 VNTKGSYECVCPPGRRLHWNGKDCVE--TGKCLS 409



 Score = 78.6 bits (192), Expect = 9e-14
 Identities = 48/135 (35%), Positives = 59/135 (43%), Gaps = 10/135 (7%)

Query: 2614 DVDEC-DGNHRCQHG--CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSA--S 2668
            DVDEC +G   C     CQN    Y+C C  GY    +  QC D +EC N    G     
Sbjct: 33   DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVHE 90

Query: 2669 CYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRV 2728
            C N  G+Y+C C  GF        C DV+EC  +   C   C N  G Y C C  G++  
Sbjct: 91   CINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLS 150

Query: 2729 GQGH-CV--SGMGFN 2740
               H C+  S  G N
Sbjct: 151  DNQHTCIHRSNEGMN 165



 Score = 35.0 bits (79), Expect = 1.1
 Identities = 47/198 (23%), Positives = 69/198 (34%), Gaps = 39/198 (19%)

Query: 2016 DTNECVALPGSCSPGTCQNLEGSFRCI-CPPGYEVKSENCIDINECDEDPNICLFGSCTN 2074
            +  +CV    SC PGT Q++EG   C  CP    +      +++EC         G C  
Sbjct: 642  ELGQCV----SCMPGTYQDMEGQLSCTPCPSSDGLGLPGARNVSECG--------GQC-- 687

Query: 2075 TPGGFQC-------LCPPGFVLSDNGRR-CFDTRQSFC-----FTNFENGK----CSVPK 2117
            +PG F          CP G    + GR  CF             T+F++ +    CS   
Sbjct: 688  SPGFFSADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTSFQDCEAKVHCSPGH 747

Query: 2118 AFNTTKAKCC---CSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNE 2174
             +NTT  +C          E   + C  CP +    F       H           D   
Sbjct: 748  HYNTTTHRCIRCPVGTYQPEFGQNHCITCPGNTSTDFDGSTNVTHCKNQHCGGELGDYTG 807

Query: 2175 CLESPG----ICSNGQCI 2188
             +ESP       +N +C+
Sbjct: 808  YIESPNYPGDYPANAECV 825



 Score = 33.9 bits (76), Expect = 2.4
 Identities = 33/124 (26%), Positives = 43/124 (34%), Gaps = 32/124 (25%)

Query: 250 PCEMCPA---QPQPCRRGFIPN-----IRTGACQDVDECQAIPGICQGGNCINTVGSFEC 301
           PC+ CP    QP+P R G  P       +        +C+A    C  G+  NT      
Sbjct: 699 PCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTSFQDCEAKVH-CSPGHHYNTTTHRCI 757

Query: 302 RCPAGHKQSETTQKCEDIDECSIIPG-------------ICETGECSNTVGSYFCVCPRG 348
           RCP G  Q E  Q     + C   PG              C+   C   +G Y      G
Sbjct: 758 RCPVGTYQPEFGQ-----NHCITCPGNTSTDFDGSTNVTHCKNQHCGGELGDY-----TG 807

Query: 349 YVTS 352
           Y+ S
Sbjct: 808 YIES 811


>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
          Length = 3144

 Score =  246 bits (628), Expect = 2e-64
 Identities = 286/1141 (25%), Positives = 451/1141 (39%), Gaps = 228/1141 (19%)

Query: 1084 CTYGKCRNTIG-----------SFKCRCNSGFALDMEERNCTDI-DECRISPDLCGSGIC 1131
            C++  C+N              +++C C+  F      +NC++I  +C+  P +C  G C
Sbjct: 217  CSFKPCKNNGSCINKRENWDEQAYECVCHPPFT----GKNCSEIIGQCQ--PHVCFHGNC 270

Query: 1132 VN-TPGSFECECFEGYESGF--MMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLG 1188
             N T  SF CEC E +   F  +  K C+ +       L  + G C N+  ++  +CP G
Sbjct: 271  SNITSNSFICECDEQFSGPFCEVSAKPCVSL-------LFWKRGICPNSSSAYTYECPKG 323

Query: 1189 HELSPSREDCVDINECSLSDNLCRNGK-CVNMIGTYQCSCNPGYQATPDRQGCTDIDECM 1247
               S S+    D++E SL    C+NG  C+ +     C C+P +     +   T  +   
Sbjct: 324  ---SSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFP 378

Query: 1248 IMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCAD-IDECENNPDICDGGQ-CTNIPGE 1305
            + N   +  C   E  Y CSC  G+      ++C   ID C+     C   + C NI G 
Sbjct: 379  LRN---NATCKKCEKDYPCSCISGFT----EKNCEKAIDHCKLLSINCLNEEWCFNIIGR 431

Query: 1306 YRCLCYDGFMAS--MDMKTCIDVNECDLNSNICMFGECENT-KGSFICHCQLGYSVKKGT 1362
            ++ +C  G   +    +K    +++      +   G C++     F    QLG++  +G 
Sbjct: 432  FKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGE 491

Query: 1363 TGCTDVDECEIGAHNCDMHASCLNIPGSFKCSC---REGW---IGNGIKCIDLDECS--- 1413
                 +D     A NC   A+ +N P     SC    EG      NG  C+  ++     
Sbjct: 492  KCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYR 551

Query: 1414 ------------------NGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAE 1455
                              +  ++C   A C +     RC+CS  + G      +VD C  
Sbjct: 552  YLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSLSYIGR-LCVVNVDYCLG 610

Query: 1456 NINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQ-DIDECSFQNICVFGTCNNLPGMFH 1514
            N ++  +G CL +  ++ C C        +   C+ D ++C   +     T  +L G F 
Sbjct: 611  NHSISVHGLCLAL--SHNCNCSG--LQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFF 666

Query: 1515 CICDDGYELDRTGGNCT-DIDECADPINCVNGL-CVNTPGRYECNCPPDFQLNPTGVGCV 1572
              C  G++    G  C  DIDECA    C NG  C++ PG Y C C P F++   G  C+
Sbjct: 667  RKCVPGFK----GTQCEIDIDECASH-PCKNGATCIDQPGNYFCQCVPPFKV-VDGFSCL 720

Query: 1573 DNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCE---TCPPVNSTEY 1629
             N            G   + C  +I          C L     N CE   TC  ++ +  
Sbjct: 721  CNP-----------GYVGIRCEQDIDD--------CIL-----NACEHNSTCKDLHLSYQ 756

Query: 1630 YTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGN-CINTFGSFQCECPQGYYLSEDTR 1688
                   EG          ++ +EC+  P  C+  + C + + S++CEC  G+       
Sbjct: 757  CVCLSDWEG------NFCEQESNECKMNP--CKNNSTCTDLYKSYRCECTSGW---TGQN 805

Query: 1689 ICEDIDECFAHPGVCGPGTCYNTL--GNYTCICPPEYMQ--VNGGHNCMDMRKSFCYRSY 1744
              E+I+EC + P + G G C+ +   G + C+CPP Y     +  +N  D+  + C    
Sbjct: 806  CSEEINECDSDPCMNG-GLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCR--- 861

Query: 1745 NGTTCENELPFNVTKRMCCCTYNVGKAWNKPCE---------PCPTPGTAD-----FKTI 1790
            N +TC   L      + C C         K CE          C   G  +     F+ I
Sbjct: 862  NNSTC---LALVDANQHCICREEFE---GKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCI 915

Query: 1791 CGNIPGFTFDIHTGKAVDIDECKEIPGICAN-GVCINQIGSFRCECPTGFSYNDLLLVCE 1849
            C   PGF+  +     ++I+EC   P  C N G C++    F C C   +        CE
Sbjct: 916  CR--PGFSGSLCE---IEINECSSEP--CKNNGTCVDLTNRFFCNCEPEYHGP----FCE 964

Query: 1850 -DIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSH-GL 1907
             D+++C     L + N  C+     Y C CA G+  +     ++ +ECL  P  C H G+
Sbjct: 965  LDVNKCKISPCLDEEN--CVYRTDGYNCLCAPGY--TGINCEINLDECLSEP--CLHDGV 1018

Query: 1908 CVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTH 1967
            C+D    Y C C +GF  +  +T   + ++C  +PC +G C   +  Y C C    + T 
Sbjct: 1019 CIDGINHYTCDCKSGFFGTHCET---NANDCLSNPCLHGRCTELINEYPCSC--DADGTS 1073

Query: 1968 NNDCLDIDECSSFFGQVCRN-GRCFNEIGSFKCLCNEGYE-------------------L 2007
                + I++C+S     C N G C      F C+C  GY                    +
Sbjct: 1074 TQCKIKINDCTSI---PCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVI 1130

Query: 2008 TPDGKNCID----TNECVALPG-------------SCSP----GTCQNLEGSFRCICPPG 2046
              +G  C+D    T +C  LPG             S SP      C++    + C C PG
Sbjct: 1131 CLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPG 1190

Query: 2047 YEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFD-TRQSFCF 2105
            +     +C +  EC   PN C+   C     G  CLC PGF+    G  C D  R+  C 
Sbjct: 1191 WS--GHHCENELECI--PNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITCL 1246

Query: 2106 T 2106
            T
Sbjct: 1247 T 1247



 Score =  226 bits (575), Expect = 3e-58
 Identities = 291/1184 (24%), Positives = 445/1184 (37%), Gaps = 289/1184 (24%)

Query: 1331 LNSNICM-FGEC--ENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNI 1387
            L+S  C   G+C  E    ++ CHCQ  +S K     C ++D C      C  + SC+N 
Sbjct: 178  LSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKY----CQELDACSFKP--CKNNGSCINK 231

Query: 1388 -----PGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVN-TPGSYRCACSEGFT 1441
                   +++C C   + G     I + +C    H C  +  C N T  S+ C C E F+
Sbjct: 232  RENWDEQAYECVCHPPFTGKNCSEI-IGQCQ--PHVC-FHGNCSNITSNSFICECDEQFS 287

Query: 1442 GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRS--------CQDID 1493
            G    C    +   ++   + G C N   AY  EC  G +  +            CQ+  
Sbjct: 288  GP--FCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGT 345

Query: 1494 EC---------------------SFQNICVF------GTCNNLPGMFHCICDDGYELDRT 1526
            +C                     S Q  C         TC      + C C  G+    T
Sbjct: 346  DCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGF----T 401

Query: 1527 GGNCTD-IDECAD-PINCVNG-LCVNTPGRYECNCPPDFQLNPTGVGCVDNR---VGNCY 1580
              NC   ID C    INC+N   C N  GR++  C P         GC  N    + N Y
Sbjct: 402  EKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIP---------GCTKNPCWFLKNVY 452

Query: 1581 LKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTL-CPGGEGF 1639
            L                   + +  C C  G  +   C+   P      + L   G EG 
Sbjct: 453  L-------------------IHQHLCYC--GVTFHGICQDKGPAQFEYVWQLGFAGSEGE 491

Query: 1640 RPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDEC-FA 1698
            +                    CQG   I+ +      C +      D    ++   C F 
Sbjct: 492  K--------------------CQG--VIDAYFFLAANCTEDATYVNDPE--DNNSSCWFP 527

Query: 1699 HPG---VCGPG-TCYNTLGN--YTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENE 1752
            H G   +C  G +C +   +  Y  +C   +       N  D +++ C        C++E
Sbjct: 528  HEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHE---AVCKDE 584

Query: 1753 LPFNVTKRMCCCTYN-VGKAWNKPCEPCPTPGTADFKTIC------GNIPGFTFDIHTGK 1805
                + +  C C+ + +G+      + C    +     +C       N  G         
Sbjct: 585  ----INRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNIC 640

Query: 1806 AVDIDECKEIPGICANGVCINQI-GSFRCECPTGFSYNDLLLVCE-DIDECSNGDNLCQR 1863
             +D ++CK     C NG     + G F  +C  GF        CE DIDEC++  + C+ 
Sbjct: 641  EIDTEDCKSAS--CKNGTTSTHLRGYFFRKCVPGFKGTQ----CEIDIDECAS--HPCKN 692

Query: 1864 NADCINSPGSYRCECAAGFKLSPNGACV------------DRNECLEIPNVCSH-GLCVD 1910
             A CI+ PG+Y C+C   FK+    +C+            D ++C  I N C H   C D
Sbjct: 693  GATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDC--ILNACEHNSTCKD 750

Query: 1911 LQGSYQCICHNGFKASQDQTMCMDVDECERHPC-GNGTCKNTVGSYNCLCYPGFELTHNN 1969
            L  SYQC+C + ++ +  +    + +EC+ +PC  N TC +   SY C C  G+  T  N
Sbjct: 751  LHLSYQCVCLSDWEGNFCE---QESNECKMNPCKNNSTCTDLYKSYRCECTSGW--TGQN 805

Query: 1970 DCLDIDECSSFFGQVCRNGRCFNEI---GSFKCL---------CNEGYELTP-------- 2009
               +I+EC S     C NG   +E    G F CL         C++ Y L          
Sbjct: 806  CSEEINECDS---DPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRN 862

Query: 2010 --------------------DGKNC-IDTNECVALPGSCSP-GTCQNLEGSFRCICPPGY 2047
                                +GKNC ID  +C+ L  SC   G C+++  +FRCIC PG+
Sbjct: 863  NSTCLALVDANQHCICREEFEGKNCEIDVKDCLFL--SCQDYGDCEDMVNNFRCICRPGF 920

Query: 2048 EVKSENC-IDINECDEDPNICL-FGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCF 2105
                  C I+INEC  +P  C   G+C +    F C C P +               FC 
Sbjct: 921  --SGSLCEIEINECSSEP--CKNNGTCVDLTNRFFCNCEPEY------------HGPFC- 963

Query: 2106 TNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSL 2165
               +  KC +    +      C  +  G                 +  LC  G+  +   
Sbjct: 964  -ELDVNKCKISPCLDEEN---CVYRTDG-----------------YNCLCAPGYTGI--- 999

Query: 2166 HDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGN 2225
             +   +++ECL  P +  +G CI+    + C+C  G    + G  C       + NPC +
Sbjct: 1000 -NCEINLDECLSEPCL-HDGVCIDGINHYTCDCKSG----FFGTHCETNANDCLSNPCLH 1053

Query: 2226 GTCTNVIGSFECNCNEGFEPGPMMNCE-DINECAQNPLLCAFRCMNTFGSYECTCPIGYA 2284
            G CT +I  + C+C+     G    C+  IN+C   P +    C  +   + C CP GY 
Sbjct: 1054 GRCTELINEYPCSCD---ADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYT 1110

Query: 2285 LREDQKMCKDLDECAEGLHD---CESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VDEN 2340
                +   K +D CAE   +   C + G+       TF C C PG +    G+ C ++ N
Sbjct: 1111 GAYCE---KSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFS----GQFCEININ 1163

Query: 2341 ECRTKPGICENGR-CVNIIGSYRCECNEGFQS--SSSGTECLDN 2381
            EC + P  C +G  C + I  Y C+C  G+      +  EC+ N
Sbjct: 1164 ECSSSP--CLHGADCEDHINGYVCKCQPGWSGHHCENELECIPN 1205



 Score =  221 bits (562), Expect = 1e-56
 Identities = 311/1248 (24%), Positives = 466/1248 (37%), Gaps = 259/1248 (20%)

Query: 1569 VGCVDNRVGNCYLKFGPRGDGSLSCNTE-IGVGVSRSSCCCSLGKAWGNPCETCPPVNST 1627
            VGCV N      L FG R  G  + N++ + VG        + G +   PC     +N T
Sbjct: 112  VGCVQNTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPS---PCPLGLRLNVT 168

Query: 1628 EYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQG-GNCINTFGS--FQCECPQGYYLS 1684
                 C               E +         C G G C++   S  + C C   +   
Sbjct: 169  VKQQFCQ--------------ESLSS-----EFCSGHGKCLSEAWSKTYSCHCQPPF--- 206

Query: 1685 EDTRICEDIDECFAHPGVC-GPGTCYNTLGN-----YTCICPPEYMQVNGGHNCMDM--- 1735
               + C+++D C   P  C   G+C N   N     Y C+C P +     G NC ++   
Sbjct: 207  -SGKYCQELDACSFKP--CKNNGSCINKRENWDEQAYECVCHPPFT----GKNCSEIIGQ 259

Query: 1736 -RKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKP-CEPCPTPGTADF---KTI 1790
             +   C+       C N     +T     C  +  + ++ P CE    P  +     + I
Sbjct: 260  CQPHVCFHG----NCSN-----ITSNSFICECD--EQFSGPFCEVSAKPCVSLLFWKRGI 308

Query: 1791 CGNIPG-FTFDIHTGKA-----VDIDECKEIPGICANGV-CINQIGSFRCECPTGFSYND 1843
            C N    +T++   G +      D+ E   +P  C NG  CI       C C   F+  D
Sbjct: 309  CPNSSSAYTYECPKGSSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCICSPIFT--D 364

Query: 1844 LLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVC 1903
            LL  C+ I        L + NA C      Y C C +GF        +D  + L I N  
Sbjct: 365  LL--CKSIQTSCESFPL-RNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSI-NCL 420

Query: 1904 SHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGF 1963
            +   C ++ G ++ +C  G               C ++PC     KN    +  LCY G 
Sbjct: 421  NEEWCFNIIGRFKYVCIPG---------------CTKNPCW--FLKNVYLIHQHLCYCG- 462

Query: 1964 ELTHNNDCLDIDECSSFFGQVCRNG-------RCFNEIGSFKCL---CNEGYELTPDGKN 2013
             +T +  C D       F  V + G       +C   I ++  L   C E      D + 
Sbjct: 463  -VTFHGICQDKGPAQ--FEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPE- 518

Query: 2014 CIDTNECVALPGS-----CSPG-TCQNLEGS--FRCICPPGYEVKSENCIDINECDEDPN 2065
              D N     P       C+ G +C + E S  +R +C   +   + N    N  D+  N
Sbjct: 519  --DNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLC---FLRWAGNMYLENTTDDQEN 573

Query: 2066 ICLFGS-CTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKA 2124
             C   + C +     +C C   ++    GR C      +C  N      SV         
Sbjct: 574  ECQHEAVCKDEINRPRCSCSLSYI----GRLCV-VNVDYCLGNHS---ISVHGLCLALSH 625

Query: 2125 KCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGT-----------VPSLHDTR--ED 2171
             C CS +          +C  D E      C  G  +           VP    T+   D
Sbjct: 626  NCNCSGLQRY----ERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEID 681

Query: 2172 VNECLESPGICSNGQ-CINTDGSFRCECPMGY----------NLDYTGVRCV-DTDECSI 2219
            ++EC   P  C NG  CI+  G++ C+C   +          N  Y G+RC  D D+C +
Sbjct: 682  IDECASHP--CKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCIL 739

Query: 2220 GNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCE-DINECAQNPLLCAFRCMNTFGSYECT 2278
                 N TC ++  S++C C   +E      CE + NEC  NP      C + + SY C 
Sbjct: 740  NACEHNSTCKDLHLSYQCVCLSDWEGN---FCEQESNECKMNPCKNNSTCTDLYKSYRCE 796

Query: 2279 CPIGYALREDQKMCKDLDECAEGLHDCES----RGMMC--KNLIGTFMCICPPGMARRPD 2332
            C  G+  +           C+E +++C+S     G +C    + G F+C+CPP       
Sbjct: 797  CTSGWTGQN----------CSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYT---- 842

Query: 2333 GEGCVDE-NECRTKPGICENGR-CVNII-GSYRCECNEGFQSSSSGTECLDNRQGLCFAE 2389
            G+ C    N C      C N   C+ ++  +  C C E F+  +   +  D         
Sbjct: 843  GQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKD--------- 893

Query: 2390 VLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRD 2449
             L   CQ      ++V    C C  G   G  CE+                        +
Sbjct: 894  CLFLSCQDYGDCEDMVNNFRCICRPGFS-GSLCEI------------------------E 928

Query: 2450 IDECKVMPNLC-TNGQCINTMGSFRCFCKVGYTTDISGTSC-IDLDECSQSPKPCNYICK 2507
            I+EC   P  C  NG C++    F C C+  Y     G  C +D+++C  SP      C 
Sbjct: 929  INECSSEP--CKNNGTCVDLTNRFFCNCEPEY----HGPFCELDVNKCKISPCLDEENCV 982

Query: 2508 NTEGSYQCSCPRGYVLQEDGKTCK-DLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHH 2566
                 Y C C  GY     G  C+ +LDEC ++      +C++ +  +TC C  GF   H
Sbjct: 983  YRTDGYNCLCAPGYT----GINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTH 1038

Query: 2567 TACIDN-NECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCE-DVDECDGNHRC 2624
              C  N N+C S P L G    C      + C C      D T   C+  +++C      
Sbjct: 1039 --CETNANDCLSNPCLHGR---CTELINEYPCSCDA----DGTSTQCKIKINDCTSIPCM 1089

Query: 2625 QHG-CQNILGGYRCGCPQGYIQHYQWNQCVD---ENECSNPNACGSASCYNTLG-SYKCA 2679
              G CQ    G+ C CP+GY   Y   + +D   E E ++        C +  G ++ C 
Sbjct: 1090 NEGFCQKSAHGFTCICPRGYTGAY-CEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCR 1148

Query: 2680 CPSGFSFDQFSSACHDVNECSSSKNPCNYG--CSNTEGGYLCGCPPGY 2725
            C  GFS  QF     ++NECSSS  PC +G  C +   GY+C C PG+
Sbjct: 1149 CLPGFS-GQFCEI--NINECSSS--PCLHGADCEDHINGYVCKCQPGW 1191



 Score =  218 bits (555), Expect = 7e-56
 Identities = 269/1082 (24%), Positives = 409/1082 (37%), Gaps = 208/1082 (19%)

Query: 602  CNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGS--FKCICKPGFVLAPNGRYCTDV 659
            C  G  L    K     +  ++     +G C++E  S  + C C+P F    +G+YC ++
Sbjct: 159  CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPF----SGKYCQEL 214

Query: 660  DECQTPGICMNGHCIN-----SEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGV 714
            D C       NG CIN      E ++ C C P       G+ C      S   G  +  V
Sbjct: 215  DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFT----GKNC------SEIIGQCQPHV 264

Query: 715  CVRPFPGAVTKSECCCANPDYGFGEPCQ----PCPA----------KNSAEFHGLCSSGV 760
            C       +T +   C   +   G  C+    PC +           +S+ +   C  G 
Sbjct: 265  CFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGS 324

Query: 761  GITVDGRDINECALDPDICANGI-CENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRL 819
                   D++E +L P  C NG  C  +     C C+    P  +   C  I     +  
Sbjct: 325  SSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCICS----PIFTDLLCKSIQTSCESFP 378

Query: 820  LCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECE--SNPCVNGA-CRNNLGSFNCE 876
            L +N  C+     Y C+C  G+   TE    + I+ C+  S  C+N   C N +G F   
Sbjct: 379  LRNNATCKKCEKDYPCSCISGF---TEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYV 435

Query: 877  CSPGSKLSSTGLICIDSLKGTCWL--NIQDSRCEVNINGATLKSECCATLGAAWGSPCER 934
            C PG              K  CW   N+      +   G T     C   G A       
Sbjct: 436  CIPG------------CTKNPCWFLKNVYLIHQHLCYCGVTFHG-ICQDKGPA------- 475

Query: 935  CELDTACPRGLARIKGVTCEDVNECEVF--PGVCPNGRCVNSKGSFHCEC---PEGL-TL 988
             + +     G A  +G  C+ V +   F       +   VN     +  C    EG   +
Sbjct: 476  -QFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEI 534

Query: 989  DGTGRVCLDIRMEQ-----CYLKW------------DEDECIHPVPGKFRMD--ACCCA- 1028
               G  CL     Q     C+L+W             E+EC H    K  ++   C C+ 
Sbjct: 535  CANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSL 594

Query: 1029 --VGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTY 1086
              +G       + C    +     LC   +   N     +G   Y + N C+     C  
Sbjct: 595  SYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCN----CSGLQRY-ERNICEIDTEDCKS 649

Query: 1087 GKCRNTI------GSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSG-ICVNTPGSFE 1139
              C+N        G F  +C  GF     E    DIDEC   P  C +G  C++ PG++ 
Sbjct: 650  ASCKNGTTSTHLRGYFFRKCVPGFKGTQCE---IDIDECASHP--CKNGATCIDQPGNYF 704

Query: 1140 CECFEGYE----------SGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGH 1189
            C+C   ++           G++ ++   DID+C  N       TC +   S+QC C    
Sbjct: 705  CQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACE-HNSTCKDLHLSYQCVCLSDW 763

Query: 1190 ELSPSREDCVDINECSLSDNLCRNGK-CVNMIGTYQCSCNPGYQATPDRQGCTDIDECMI 1248
            E +   ++    NEC +  N C+N   C ++  +Y+C C  G+      +   + D    
Sbjct: 764  EGNFCEQES---NECKM--NPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPC 818

Query: 1249 MNGGCDTQCTNSEGSYECSCSEGY--------------------------ALMPDGRSCA 1282
            MNGG   + T   G + C C   Y                          AL+   + C 
Sbjct: 819  MNGGLCHEST-IPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCI 877

Query: 1283 DIDE-----CENNPDIC------DGGQCTNIPGEYRCLCYDGFMASMDMKTC-IDVNECD 1330
              +E     CE +   C      D G C ++   +RC+C  GF  S+    C I++NEC 
Sbjct: 878  CREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSL----CEIEINEC- 932

Query: 1331 LNSNICM-FGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPG 1389
             +S  C   G C +    F C+C+  Y    G     DV++C+I    C    +C+    
Sbjct: 933  -SSEPCKNNGTCVDLTNRFFCNCEPEY---HGPFCELDVNKCKISP--CLDEENCVYRTD 986

Query: 1390 SFKCSCREGWIGNGIKC-IDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCS 1448
             + C C  G+   GI C I+LDEC   +  C  +  C++    Y C C  GF G     +
Sbjct: 987  GYNCLCAPGY--TGINCEINLDECL--SEPCLHDGVCIDGINHYTCDCKSGFFGTHCE-T 1041

Query: 1449 DVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQ-DIDECSFQNICVFGTCN 1507
            + ++C    N C +G+C  +   Y C C+   T    S  C+  I++C+       G C 
Sbjct: 1042 NANDCLS--NPCLHGRCTELINEYPCSCDADGT----STQCKIKINDCTSIPCMNEGFCQ 1095

Query: 1508 NLPGMFHCICDDGYELDRTGGNC-TDIDECADP----INCVN-GLCVNTPGR-YECNCPP 1560
                 F CIC  GY    TG  C   ID CA+P    + C+N G+CV+ PG  ++C C P
Sbjct: 1096 KSAHGFTCICPRGY----TGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLP 1151

Query: 1561 DF 1562
             F
Sbjct: 1152 GF 1153



 Score =  209 bits (533), Expect = 2e-53
 Identities = 295/1204 (24%), Positives = 463/1204 (38%), Gaps = 222/1204 (18%)

Query: 476  VGAGGQGPIITGLTILNQTI--DICKHH--ANLCL-NGRCIPTVSS--YRCECNMGYKQD 528
            V A G  P   GL  LN T+    C+    +  C  +G+C+    S  Y C C   +   
Sbjct: 151  VMASGPSPCPLGLR-LNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPF--- 206

Query: 529  ANGDCIDVDECTSNPC-TNGDCVN-----TPGSYYCKCHAGFQRTPTKQACIDIDECIQN 582
            +   C ++D C+  PC  NG C+N        +Y C CH  F    T + C +I    Q 
Sbjct: 207  SGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPF----TGKNCSEIIGQCQP 262

Query: 583  GVLCKNGRCVN-TDGSFQCICNAGFELTTDGKNC-VDHDECTTTNMCLNGMCINEDGSFK 640
             V C +G C N T  SF C C+  F     G  C V    C +      G+C N   ++ 
Sbjct: 263  HV-CFHGNCSNITSNSFICECDEQF----SGPFCEVSAKPCVSLLFWKRGICPNSSSAYT 317

Query: 641  CICKPG------------FVLAP--NGRYCTDVD---------------------ECQTP 665
              C  G            F L P  NG  C  +                       C++ 
Sbjct: 318  YECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESF 377

Query: 666  GICMNGHCINSEGSFRCDCPPGL-------AVGMDGRVCVDTHMRSTCYG--GIKKGVCV 716
             +  N  C   E  + C C  G        A+     + ++      C+   G  K VC+
Sbjct: 378  PLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCI 437

Query: 717  RPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC-SSGVGITVDGRDINECALD 775
               PG  TK+ C      Y   +    C       FHG+C   G         +     +
Sbjct: 438  ---PGC-TKNPCWFLKNVYLIHQHLCYC----GVTFHGICQDKGPAQFEYVWQLGFAGSE 489

Query: 776  PDICANGICENLRGSYRCNCNSGY--EPDASGRNCIDIDECLVNRLLCDNGL-CRNTPGS 832
             + C   I      +  C  ++ Y  +P+ +  +C    E    + +C NG  C +   S
Sbjct: 490  GEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHE--GTKEICANGCSCLSEEDS 547

Query: 833  ----YSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGL 888
                Y C          E  T +  NEC+        C++ +    C CS    LS  G 
Sbjct: 548  QEYRYLCFLRWAGNMYLENTTDDQENECQH----EAVCKDEINRPRCSCS----LSYIGR 599

Query: 889  ICI-----------DSLKGTCWLNIQDSRC----EVNINGATLKSECCATLGAAWGSPCE 933
            +C+            S+ G C     +  C        N   + +E C +     G+   
Sbjct: 600  LCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSASCKNGTTST 659

Query: 934  --RCELDTACPRGLARIKGVTCE-DVNECEVFPGVCPNG-RCVNSKGSFHCEC-PEGLTL 988
              R      C  G    KG  CE D++EC   P  C NG  C++  G++ C+C P    +
Sbjct: 660  HLRGYFFRKCVPG---FKGTQCEIDIDECASHP--CKNGATCIDQPGNYFCQCVPPFKVV 714

Query: 989  DGTGRVC----LDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPG 1044
            DG   +C    + IR EQ     D D+CI        ++AC          E     K  
Sbjct: 715  DGFSCLCNPGYVGIRCEQ-----DIDDCI--------LNAC----------EHNSTCKDL 751

Query: 1045 TKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGF 1104
               Y+ +C              G    ++ NECK  P       C +   S++C C SG+
Sbjct: 752  HLSYQCVCLSD---------WEGNFCEQESNECKMNP-CKNNSTCTDLYKSYRCECTSGW 801

Query: 1105 ALDMEERNCT-DIDECRISPDLCGSGICVNT--PGSFECECFEGYESGFMMMKNCMDIDE 1161
                  +NC+ +I+EC   P + G G+C  +  PG F C C   Y   F   +   ++ +
Sbjct: 802  T----GQNCSEEINECDSDPCMNG-GLCHESTIPGQFVCLCPPLYTGQFCHQR--YNLCD 854

Query: 1162 CERNPLLCR-GGTCVN-TEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRN-GKCVN 1218
               NP  CR   TC+   + +  C C    E    +   +D+ +C      C++ G C +
Sbjct: 855  LLHNP--CRNNSTCLALVDANQHCIC---REEFEGKNCEIDVKDCLFLS--CQDYGDCED 907

Query: 1219 MIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDG 1278
            M+  ++C C PG+  +       +I+EC       +  C +    + C+C   Y     G
Sbjct: 908  MVNNFRCICRPGFSGSLCE---IEINECSSEPCKNNGTCVDLTNRFFCNCEPEY----HG 960

Query: 1279 RSC-ADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICM 1337
              C  D+++C+ +P + D   C      Y CLC  G+     +   I+++EC L+     
Sbjct: 961  PFCELDVNKCKISPCL-DEENCVYRTDGYNCLCAPGYTG---INCEINLDEC-LSEPCLH 1015

Query: 1338 FGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCRE 1397
             G C +    + C C+ G+    GT   T+ ++C     N  +H  C  +   + CSC  
Sbjct: 1016 DGVCIDGINHYTCDCKSGFF---GTHCETNANDC---LSNPCLHGRCTELINEYPCSCDA 1069

Query: 1398 GWIGNGIKC-IDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAE- 1455
               G   +C I +++C+  +  C     C  +   + C C  G+TG  +    +D CAE 
Sbjct: 1070 D--GTSTQCKIKINDCT--SIPCMNEGFCQKSAHGFTCICPRGYTG-AYCEKSIDNCAEP 1124

Query: 1456 --NINLCENGQ-CLNVPG-AYRCECEMGFTPASDSRSCQ-DIDECSFQNICVFGT-CNNL 1509
              N  +C NG  C++ PG  + C C  GF+     + C+ +I+ECS  + C+ G  C + 
Sbjct: 1125 ELNSVICLNGGICVDGPGHTFDCRCLPGFS----GQFCEININECS-SSPCLHGADCEDH 1179

Query: 1510 PGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGV 1569
               + C C  G+    +G +C +  EC  P +CV+ LC+       C C P F     G+
Sbjct: 1180 INGYVCKCQPGW----SGHHCENELECI-PNSCVHELCMENEPGSTCLCTPGFMTCSIGL 1234

Query: 1570 GCVD 1573
             C D
Sbjct: 1235 LCGD 1238



 Score =  190 bits (483), Expect = 2e-47
 Identities = 283/1079 (26%), Positives = 413/1079 (38%), Gaps = 208/1079 (19%)

Query: 1649 EDIDECQELPGLCQGGNCIN-TFGSFQCECPQ---GYYLSEDTRICEDIDECFAHPGVCG 1704
            E I +CQ  P +C  GNC N T  SF CEC +   G +     + C  +   F   G+C 
Sbjct: 255  EIIGQCQ--PHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL--LFWKRGICP 310

Query: 1705 PGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTC---ENELPFNVTKRM 1761
                 N+   YT  CP      NG  +  +     C    NGT C    N++       M
Sbjct: 311  -----NSSSAYTYECPKGSSSQNGETDVSEFSLVPCQ---NGTDCIKISNDV-------M 355

Query: 1762 CCC----TYNVGKAWNKPCEPCPTPGTADFKTI-----CGNIPGFTFDIHTGKAVDIDEC 1812
            C C    T  + K+    CE  P    A  K       C  I GFT + +  KA  ID C
Sbjct: 356  CICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFT-EKNCEKA--IDHC 412

Query: 1813 KEIPGICANGV-CINQIGSFRCECPTGFSYN------DLLLVCEDIDECS-NGDNLCQRN 1864
            K +   C N   C N IG F+  C  G + N      ++ L+ + +  C      +CQ  
Sbjct: 413  KLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDK 472

Query: 1865 ADC-------INSPGSYRCECA----AGFKLSPNGACV----------DRNECLEIPN-- 1901
                      +   GS   +C     A F L+ N  C           D N     P+  
Sbjct: 473  GPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAAN--CTEDATYVNDPEDNNSSCWFPHEG 530

Query: 1902 ---VCSHGL-CVDLQGS----YQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVG 1953
               +C++G  C+  + S    Y C          + T     +EC+        CK+ + 
Sbjct: 531  TKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHE----AVCKDEIN 586

Query: 1954 SYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKN 2013
               C C            +++D C      +  +G C     +  C   + YE     +N
Sbjct: 587  RPRCSC--SLSYIGRLCVVNVDYCLGNHS-ISVHGLCLALSHNCNCSGLQRYE-----RN 638

Query: 2014 C--IDTNECVALPGSCSPGTCQ-NLEGSFRCICPPGYEVKSENC-IDINECDEDPNICLF 2069
               IDT +C +   SC  GT   +L G F   C PG+  K   C IDI+EC   P  C  
Sbjct: 639  ICEIDTEDCKS--ASCKNGTTSTHLRGYFFRKCVPGF--KGTQCEIDIDECASHP--CKN 692

Query: 2070 GS-CTNTPG--------------GFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCS 2114
            G+ C + PG              GF CLC PG+V    G RC            E+   S
Sbjct: 693  GATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYV----GIRCEQDIDDCILNACEHN--S 746

Query: 2115 VPKAFNTTKAKCCCSKMPG---EGWGDPCELCPKDDEVAFQDL-----CPYGHGTVPSLH 2166
              K  + +    C S   G   E   + C++ P  +     DL     C    G      
Sbjct: 747  TCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQ-- 804

Query: 2167 DTREDVNECLESPGICSNGQCINTD---GSFRCECPMGYNLDYTGVRCVDTDECSIGNPC 2223
            +  E++NEC   P  C NG   +     G F C CP  Y   +   R    D   + NPC
Sbjct: 805  NCSEEINECDSDP--CMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCD--LLHNPC 860

Query: 2224 -GNGTCTNVIGSFE-CNCNEGFEPGPMMNCE-DINECAQNPLLCAFRCMNTFGSYECTCP 2280
              N TC  ++ + + C C E FE     NCE D+ +C          C +   ++ C C 
Sbjct: 861  RNNSTCLALVDANQHCICREEFEG---KNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICR 917

Query: 2281 IGYALREDQKMCK-DLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VD 2338
             G++      +C+ +++EC+     C++ G  C +L   F C C P       G  C +D
Sbjct: 918  PGFS----GSLCEIEINECSS--EPCKNNGT-CVDLTNRFFCNCEPEY----HGPFCELD 966

Query: 2339 ENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGT---ECLDN---RQGLCFAEVLQ 2392
             N+C+  P + E   CV     Y C C  G+   +      ECL       G+C   +  
Sbjct: 967  VNKCKISPCLDEEN-CVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINH 1025

Query: 2393 TICQMASS--SRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDI 2450
              C   S     +  T +  C       G   EL       +Y   C        DG   
Sbjct: 1026 YTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELIN-----EYPCSCD------ADGTST 1074

Query: 2451 DECKVMPNLCTNGQCIN------TMGSFRCFCKVGYTTDISGTSCI-DLDECSQSPKPCN 2503
             +CK+  N CT+  C+N      +   F C C  GYT    G  C   +D C++ P+  +
Sbjct: 1075 -QCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYT----GAYCEKSIDNCAE-PELNS 1128

Query: 2504 YICKN----TEG---SYQCSCPRGYVLQEDGKTCK-DLDECQTKQHNCQFLCVNTLGGFT 2555
             IC N     +G   ++ C C  G+     G+ C+ +++EC +        C + + G+ 
Sbjct: 1129 VICLNGGICVDGPGHTFDCRCLPGF----SGQFCEININECSSSPCLHGADCEDHINGYV 1184

Query: 2556 CKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCED 2614
            CKC PG++ HH  C +  EC   P+ C  +   +N PGS +C C  GF   + GL C D
Sbjct: 1185 CKCQPGWSGHH--CENELEC--IPNSCVHELCMENEPGS-TCLCTPGFMTCSIGLLCGD 1238



 Score =  184 bits (466), Expect = 1e-45
 Identities = 310/1242 (24%), Positives = 432/1242 (34%), Gaps = 297/1242 (23%)

Query: 153  CMNGGTCADD------HCQCQKGYIGTYCGQ-PVCE-NGCQNGGRCIGPNR--------C 196
            C   G C  +       C CQ  + G YC +   C    C+N G CI            C
Sbjct: 183  CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242

Query: 197  ACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPA 256
             C   FTG  C      G C   V      G  + I     +C       +  P   C  
Sbjct: 243  VCHPPFTGKNCSEII--GQCQPHV---CFHGNCSNITSNSFIC--ECDEQFSGP--FCEV 293

Query: 257  QPQPC------RRGFIPNIR---TGACQ----------DVDECQAIPGICQGG-NCINTV 296
              +PC      +RG  PN     T  C           DV E   +P  CQ G +CI   
Sbjct: 294  SAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVP--CQNGTDCIKIS 351

Query: 297  GSFECRCPAGHKQSETTQKCEDID-ECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDG 355
                C C        T   C+ I   C   P +     C      Y C C  G+ T  + 
Sbjct: 352  NDVMCIC----SPIFTDLLCKSIQTSCESFP-LRNNATCKKCEKDYPCSCISGF-TEKNC 405

Query: 356  SRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCC--CEPGRCWGIGTIPEACPVRGSEEY 413
             + ID    +  + L    C   + GR  K  C   C    CW +  +           +
Sbjct: 406  EKAIDHCKLLSINCLNEEWCFNII-GRF-KYVCIPGCTKNPCWFLKNVYLI--------H 455

Query: 414  RRLCMDGLPMGGIPGSAGSRP-------GGTGGNGFAPSGNGNGYG------PGGTGFIP 460
            + LC  G+   GI    G          G  G  G    G  + Y            ++ 
Sbjct: 456  QHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVN 515

Query: 461  IPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSS--YR 518
             P  N  S      G                  T +IC   AN C    C+    S  YR
Sbjct: 516  DPEDNNSSCWFPHEG------------------TKEIC---ANGC---SCLSEEDSQEYR 551

Query: 519  CEC------NMGYKQDANGDCIDVDECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQA 572
              C      NM Y ++   D    +EC        D +N P    C C   +     +  
Sbjct: 552  YLCFLRWAGNM-YLENTTDD--QENECQHEAVCK-DEINRPR---CSCSLSYIG---RLC 601

Query: 573  CIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMC 632
             +++D C+ N  +  +G C+    S  C C+ G +        +D ++C + + C NG  
Sbjct: 602  VVNVDYCLGNHSISVHGLCLAL--SHNCNCS-GLQRYERNICEIDTEDCKSAS-CKNGTT 657

Query: 633  INE-DGSFKCICKPGFVLAPNGRYCT-DVDECQTPGICMNGH-CINSEGSFRCDCPPGLA 689
                 G F   C PGF     G  C  D+DEC +   C NG  CI+  G++ C       
Sbjct: 658  STHLRGYFFRKCVPGF----KGTQCEIDIDECASHP-CKNGATCIDQPGNYFCQ------ 706

Query: 690  VGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNS 749
                                     CV PF   V     C  NP Y              
Sbjct: 707  -------------------------CVPPFK--VVDGFSCLCNPGY-------------- 725

Query: 750  AEFHGLCSSGVGITVDGRDINECALDPDICA-NGICENLRGSYRCNCNSGYEPDASGRNC 808
                      VGI  + +DI++C L+   C  N  C++L  SY+C C S +E    G  C
Sbjct: 726  ----------VGIRCE-QDIDDCILNA--CEHNSTCKDLHLSYQCVCLSDWE----GNFC 768

Query: 809  I-DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGA-C 866
              + +EC +N    +N  C +   SY C C  G+   T     E+INEC+S+PC+NG  C
Sbjct: 769  EQESNECKMNPCK-NNSTCTDLYKSYRCECTSGW---TGQNCSEEINECDSDPCMNGGLC 824

Query: 867  RNNL--GSFNCECSP-------------------GSKLSSTGLICIDSLKG-TCWLNIQD 904
              +   G F C C P                     + +ST L  +D+ +   C    + 
Sbjct: 825  HESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEG 884

Query: 905  SRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLAR--IKGVTCE-DVNECEV 961
              CE+++         C  L       CE    +  C   + R    G  CE ++NEC  
Sbjct: 885  KNCEIDVKD-------CLFLSCQDYGDCEDMVNNFRC---ICRPGFSGSLCEIEINECSS 934

Query: 962  FPGVCP-NGRCVNSKGSFHCECPEGLTLDGTGRVC-LDIRMEQCYLKWDEDECIHPVPGK 1019
             P  C  NG CV+    F C C      +  G  C LD+   +     DE+ C++   G 
Sbjct: 935  EP--CKNNGTCVDLTNRFFCNCEP----EYHGPFCELDVNKCKISPCLDEENCVYRTDGY 988

Query: 1020 FRMDACCCAVGAAWGTECE----ECPK----------PGTKEYETLCPRGAGFANRGDVL 1065
                 C CA G   G  CE    EC             G   Y   C  G          
Sbjct: 989  ----NCLCAPGYT-GINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSG---------F 1034

Query: 1066 TGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNC-TDIDECRISPD 1124
             G     + N+C + P  C +G+C   I  + C C++    D     C   I++C   P 
Sbjct: 1035 FGTHCETNANDCLSNP--CLHGRCTELINEYPCSCDA----DGTSTQCKIKINDCTSIPC 1088

Query: 1125 LCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEG-SFQ 1182
            +   G C  +   F C C  GY +G    K+  +  E E N ++C  GG CV+  G +F 
Sbjct: 1089 M-NEGFCQKSAHGFTCICPRGY-TGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFD 1146

Query: 1183 CDCPLGHELSPSREDC-VDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCT 1241
            C C  G     S + C ++INECS S  L     C + I  Y C C PG+        C 
Sbjct: 1147 CRCLPGF----SGQFCEININECSSSPCL-HGADCEDHINGYVCKCQPGWSG----HHCE 1197

Query: 1242 DIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCAD 1283
            +  EC I N      C  +E    C C+ G+     G  C D
Sbjct: 1198 NELEC-IPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGD 1238



 Score =  137 bits (344), Expect = 2e-31
 Identities = 210/918 (22%), Positives = 326/918 (35%), Gaps = 208/918 (22%)

Query: 1944 GNGTCKNTVGS--YNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFN-----EIGS 1996
            G+G C +   S  Y+C C P F   +   C ++D CS  F     NG C N     +  +
Sbjct: 185  GHGKCLSEAWSKTYSCHCQPPFSGKY---CQELDACS--FKPCKNNGSCINKRENWDEQA 239

Query: 1997 FKCLCNEGYELTPDGKNCIDT-NECVALPGSCSPGTCQNL-EGSFRCICP-----PGYEV 2049
            ++C+C+  +     GKNC +   +C   P  C  G C N+   SF C C      P  EV
Sbjct: 240  YECVCHPPFT----GKNCSEIIGQCQ--PHVCFHGNCSNITSNSFICECDEQFSGPFCEV 293

Query: 2050 KSENCIDINECDEDPNICLF---GSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFT 2106
             ++ C+ +          LF   G C N+   +   CP G   S NG         F   
Sbjct: 294  SAKPCVSL----------LFWKRGICPNSSSAYTYECPKGSS-SQNGETDVS---EFSLV 339

Query: 2107 NFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLH 2166
              +NG   +  +       C CS +                   F DL            
Sbjct: 340  PCQNGTDCIKIS---NDVMCICSPI-------------------FTDLLC---------- 367

Query: 2167 DTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNG 2226
               + +    ES  + +N  C   +  + C C  G+  +    + +D  +    N     
Sbjct: 368  ---KSIQTSCESFPLRNNATCKKCEKDYPCSCISGFT-EKNCEKAIDHCKLLSINCLNEE 423

Query: 2227 TCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFR----CMNTF-GSYECTCPI 2281
             C N+IG F+  C  G    P    +++    Q+   C       C +     +E    +
Sbjct: 424  WCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQL 483

Query: 2282 GYALREDQK----------MCKDLDECAEGLHDCESRGMMC-------KNLIGT------ 2318
            G+A  E +K          +  +  E A  ++D E     C       K +         
Sbjct: 484  GFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLS 543

Query: 2319 ------FMCICPPGMARRPDGEGCVD--ENECRTKPGICENGRCVNIIGSYRCECNEGFQ 2370
                  +  +C    A     E   D  ENEC+          C + I   RC C+  + 
Sbjct: 544  EEDSQEYRYLCFLRWAGNMYLENTTDDQENECQ------HEAVCKDEINRPRCSCSLSYI 597

Query: 2371 SSSSGTE---CLDNRQ----GLCFAEVLQTICQ-MASSSRNL--VTKSEC---CCDGGRG 2417
                      CL N      GLC A      C  +    RN+  +   +C    C  G  
Sbjct: 598  GRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSASCKNGTT 657

Query: 2418 WGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQ-CINTMGSFRCFC 2476
              H            + + C  G   T    DIDEC   P  C NG  CI+  G++ C C
Sbjct: 658  STHL--------RGYFFRKCVPGFKGTQCEIDIDECASHP--CKNGATCIDQPGNYFCQC 707

Query: 2477 KVGYTTDISGTSCI------------DLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQ 2524
               +   + G SC+            D+D+C  +    N  CK+   SYQC C   +   
Sbjct: 708  VPPFKV-VDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDW--- 763

Query: 2525 EDGKTCK-DLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCG 2583
             +G  C+ + +EC+         C +    + C+C  G+T  + +  + NEC S P + G
Sbjct: 764  -EGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCS-EEINECDSDPCMNG 821

Query: 2584 AKGICQNT--PGSFSCECQRGFSLDATGLNCED-VDECDGNHR-CQHG--CQNIL-GGYR 2636
              G+C  +  PG F C C   +    TG  C    + CD  H  C++   C  ++     
Sbjct: 822  --GLCHESTIPGQFVCLCPPLY----TGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQH 875

Query: 2637 CGCPQGYIQHYQWNQC-VDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACH- 2694
            C C +     ++   C +D  +C   +      C + + +++C C  GFS     S C  
Sbjct: 876  CICRE----EFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFS----GSLCEI 927

Query: 2695 DVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTE---- 2750
            ++NECSS     N  C +    + C C P Y+               G +  LD      
Sbjct: 928  EINECSSEPCKNNGTCVDLTNRFFCNCEPEYH---------------GPFCELDVNKCKI 972

Query: 2751 ---VDEENALSPEACYEC 2765
               +DEEN +     Y C
Sbjct: 973  SPCLDEENCVYRTDGYNC 990



 Score =  130 bits (326), Expect = 2e-29
 Identities = 111/398 (27%), Positives = 174/398 (43%), Gaps = 69/398 (17%)

Query: 508  GRCIPTVSSYRCECNMGYKQDANGDC-IDVDECTSNPC-TNGDCVNTPGSYYCKCHAGFQ 565
            G C   V+++RC C  G+       C I+++EC+S PC  NG CV+    ++C C   + 
Sbjct: 903  GDCEDMVNNFRCICRPGFSGSL---CEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYH 959

Query: 566  RTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNC-VDHDECTTT 624
                +   +D+++C  +  L +      TDG + C+C  G+     G NC ++ DEC + 
Sbjct: 960  GPFCE---LDVNKCKISPCLDEENCVYRTDG-YNCLCAPGYT----GINCEINLDECLSE 1011

Query: 625  NMCLNGMCINEDGSFKCICKPGFVLAPNGRYC-TDVDECQTPGICMNGHCINSEGSFRCD 683
                +G+CI+    + C CK GF     G +C T+ ++C +   C++G C      + C 
Sbjct: 1012 PCLHDGVCIDGINHYTCDCKSGFF----GTHCETNANDCLS-NPCLHGRCTELINEYPCS 1066

Query: 684  CPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQP 743
            C        DG         ++    IK   C          +   C N  +     CQ 
Sbjct: 1067 CDA------DG---------TSTQCKIKINDC----------TSIPCMNEGF-----CQ- 1095

Query: 744  CPAKNSAEFHGLCSSGVGITVDGRDINECA---LDPDICANG-ICENLRG-SYRCNCNSG 798
               K++  F  +C  G       + I+ CA   L+  IC NG IC +  G ++ C C  G
Sbjct: 1096 ---KSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPG 1152

Query: 799  YEPDASGRNC-IDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECE 857
            +    SG+ C I+I+EC  +  L     C +    Y C C PG+        CE+  EC 
Sbjct: 1153 F----SGQFCEININECSSSPCL-HGADCEDHINGYVCKCQPGW----SGHHCENELECI 1203

Query: 858  SNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLK 895
             N CV+  C  N     C C+PG    S GL+C D ++
Sbjct: 1204 PNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIR 1241



 Score =  120 bits (300), Expect = 3e-26
 Identities = 132/546 (24%), Positives = 198/546 (36%), Gaps = 116/546 (21%)

Query: 108  NQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQC-SVRCMNGGTCADDH--- 163
            N+C +  C+N+       +   C C+SG     C S+ I +C S  CMNGG C +     
Sbjct: 773  NECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNC-SEEINECDSDPCMNGGLCHESTIPG 831

Query: 164  ---CQCQKGYIGTYCGQ-----PVCENGCQNGGRCI----GPNRCACVYGFTGPQCERDY 211
               C C   Y G +C Q      +  N C+N   C+        C C   F G  CE D 
Sbjct: 832  QFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDV 891

Query: 212  RT---------GPCFTQVNNQMCQGQLTGIVC----TKTLCCATIGRAWGHPCEMCPAQP 258
            +          G C   VNN  C       +C    + +LC   I      PC+      
Sbjct: 892  KDCLFLSCQDYGDCEDMVNNFRC-------ICRPGFSGSLCEIEINECSSEPCKNNGTCV 944

Query: 259  QPCRRGFI---PNIRTGACQ-DVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQ 314
                R F    P      C+ DV++C+  P + +  NC+     + C C  G+    T  
Sbjct: 945  DLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDE-ENCVYRTDGYNCLCAPGY----TGI 999

Query: 315  KCE-DIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNG 373
             CE ++DEC   P +   G C + +  Y C C  G+     G+ C         +  ++G
Sbjct: 1000 NCEINLDECLSEPCL-HDGVCIDGINHYTCDCKSGFF----GTHCETNANDCLSNPCLHG 1054

Query: 374  RCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCM-DGLPMGGIPGSAGS 432
            RC +     + +  C C+       GT  + C ++ ++     CM +G       G    
Sbjct: 1055 RCTE----LINEYPCSCDAD-----GTSTQ-CKIKINDCTSIPCMNEGFCQKSAHGFTCI 1104

Query: 433  RPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILN 492
             P G  G  +      N   P     I + GG                            
Sbjct: 1105 CPRGYTG-AYCEKSIDNCAEPELNSVICLNGG---------------------------- 1135

Query: 493  QTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNG-DCVN 551
                IC        + RC+P  S   CE             I+++EC+S+PC +G DC +
Sbjct: 1136 ----ICVDGPGHTFDCRCLPGFSGQFCE-------------ININECSSSPCLHGADCED 1178

Query: 552  TPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTD 611
                Y CKC  G+    +   C +  ECI N   C +  C+  +    C+C  GF   + 
Sbjct: 1179 HINGYVCKCQPGW----SGHHCENELECIPNS--CVHELCMENEPGSTCLCTPGFMTCSI 1232

Query: 612  GKNCVD 617
            G  C D
Sbjct: 1233 GLLCGD 1238



 Score =  100 bits (248), Expect = 3e-20
 Identities = 70/217 (32%), Positives = 108/217 (49%), Gaps = 31/217 (14%)

Query: 502  ANLCLNGRCIPTVSSYRCECNMGYKQDANGDC----IDVDECTSNPCTN-GDCVNTPGSY 556
            +N CL+GRC   ++ Y C C      DA+G      I +++CTS PC N G C  +   +
Sbjct: 1048 SNPCLHGRCTELINEYPCSC------DADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGF 1101

Query: 557  YCKCHAGFQRTPTKQACIDIDECIQ---NGVLCKNGR-CVNTDG-SFQCICNAGFELTTD 611
             C C  G+     +++   ID C +   N V+C NG  CV+  G +F C C  GF     
Sbjct: 1102 TCICPRGYTGAYCEKS---IDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFS---- 1154

Query: 612  GKNC-VDHDECTTTNMCLNGM-CINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICM 669
            G+ C ++ +EC+++  CL+G  C +    + C C+PG+    +G +C +  EC  P  C+
Sbjct: 1155 GQFCEININECSSSP-CLHGADCEDHINGYVCKCQPGW----SGHHCENELEC-IPNSCV 1208

Query: 670  NGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTC 706
            +  C+ +E    C C PG      G +C D   R TC
Sbjct: 1209 HELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITC 1245



 Score = 92.4 bits (228), Expect = 6e-18
 Identities = 150/653 (22%), Positives = 218/653 (33%), Gaps = 166/653 (25%)

Query: 93   FHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVR 152
            F   C PG+K    G QC + I  + C    C     C    G     C          +
Sbjct: 665  FFRKCVPGFK----GTQCEIDI--DECASHPCKNGATCIDQPGNYFCQCVPP------FK 712

Query: 153  CMNGGTCADDHCQCQKGYIGTYCGQPVCE---NGCQNGGRCIGPN---RCACVYGFTGPQ 206
             ++G +C      C  GY+G  C Q + +   N C++   C   +   +C C+  + G  
Sbjct: 713  VVDGFSCL-----CNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNF 767

Query: 207  CER---DYRTGPCFTQVNNQMCQGQLTGIVC------TKTLCCATIGRAWGHPC------ 251
            CE+   + +  PC    NN  C        C      T   C   I      PC      
Sbjct: 768  CEQESNECKMNPC---KNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLC 824

Query: 252  --------------------------EMCPAQPQPCRRGFIPNIRTGACQ---------- 275
                                       +C     PCR          A Q          
Sbjct: 825  HESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEG 884

Query: 276  -----DVDECQAIPGICQG-GNCINTVGSFECRCPAGHKQSETTQKCE-DIDECSIIPGI 328
                 DV +C  +   CQ  G+C + V +F C C  G   S     CE +I+ECS  P  
Sbjct: 885  KNCEIDVKDCLFLS--CQDYGDCEDMVNNFRCICRPGFSGS----LCEIEINECSSEP-- 936

Query: 329  CE-TGECSNTVGSYFCVCPRGY--------VTSTDGSRCIDQRTGMCFSGLVNGRCAQEL 379
            C+  G C +    +FC C   Y        V     S C+D+             C    
Sbjct: 937  CKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEE-----------NCVYRT 985

Query: 380  PGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCM-DGLPMGGIPGSAGSRPGGTG 438
             G      C C PG   GI      C +   E     C+ DG+ + GI         G  
Sbjct: 986  DG----YNCLCAPGYT-GIN-----CEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFF 1035

Query: 439  GNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDIC 498
            G     + N                    +P + G       + P        + T   C
Sbjct: 1036 GTHCETNAN----------------DCLSNPCLHGRCTELINEYPCSCD---ADGTSTQC 1076

Query: 499  KHHANLCLN------GRCIPTVSSYRCECNMGYK----QDANGDCIDVDECTSNPCTNGD 548
            K   N C +      G C  +   + C C  GY     + +  +C +  E  S  C NG 
Sbjct: 1077 KIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAE-PELNSVICLNGG 1135

Query: 549  -CVNTPG-SYYCKCHAGFQRTPTKQAC-IDIDECIQNGVLCKNGRCVNTDGSFQCICNAG 605
             CV+ PG ++ C+C  GF    + Q C I+I+EC  +  L     C +    + C C  G
Sbjct: 1136 ICVDGPGHTFDCRCLPGF----SGQFCEININECSSSPCL-HGADCEDHINGYVCKCQPG 1190

Query: 606  FELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTD 658
            +     G +C +  EC   N C++ +C+  +    C+C PGF+    G  C D
Sbjct: 1191 W----SGHHCENELEC-IPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGD 1238



 Score = 75.5 bits (184), Expect = 7e-13
 Identities = 71/285 (24%), Positives = 109/285 (38%), Gaps = 44/285 (15%)

Query: 108  NQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCAD--DH-- 163
            N+C +  C +     + +    C C+ G     C     +  S  C++ G C D  +H  
Sbjct: 968  NKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYT 1027

Query: 164  CQCQKGYIGTYC---GQPVCENGCQNGGRC---IGPNRCACVYGFTGPQCE---RDYRTG 214
            C C+ G+ GT+C         N C +G RC   I    C+C    T  QC+    D  + 
Sbjct: 1028 CDCKSGFFGTHCETNANDCLSNPCLHG-RCTELINEYPCSCDADGTSTQCKIKINDCTSI 1086

Query: 215  PCFTQVNNQMCQGQLTGIVC------TKTLCCATIGRAW-----------GHPCEMCPAQ 257
            PC   +N   CQ    G  C      T   C  +I               G  C   P  
Sbjct: 1087 PC---MNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGH 1143

Query: 258  PQPCRRGFIPNIRTGACQ-DVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKC 316
               CR   +P      C+ +++EC + P +  G +C + +  + C+C  G     +   C
Sbjct: 1144 TFDCR--CLPGFSGQFCEININECSSSPCL-HGADCEDHINGYVCKCQPGW----SGHHC 1196

Query: 317  EDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQ 361
            E+  EC  IP  C    C        C+C  G++T + G  C D+
Sbjct: 1197 ENELEC--IPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDE 1239



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 29/79 (36%), Positives = 37/79 (46%), Gaps = 15/79 (18%)

Query: 144  KSIQQCSVR------CMNGGTCADDH----CQCQKGYIGTYCGQPVCENG-CQNGGRCIG 192
            K+I+ C V       C N GTC  D+    C+C + Y G  C    CEN  C NG  C+ 
Sbjct: 2329 KNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVP 2388

Query: 193  PNR----CACVYGFTGPQC 207
             +     C C YG +GP C
Sbjct: 2389 KSGTDIVCLCPYGRSGPLC 2407



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 21/87 (24%)

Query: 144  KSIQQCS------VRCMNGGTCADD----HCQCQKGYIGTYCGQPV--CE------NGCQ 185
            +S+ QC       ++C NGGTC +     +C C  G+ G++C + V  C+      + C 
Sbjct: 2604 RSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCS 2663

Query: 186  NGGRCIG-PN--RCACVYGFTGPQCER 209
             G  CI  P+   C C  G TG  CE+
Sbjct: 2664 RGATCISLPHGYTCFCPLGTTGIYCEQ 2690



 Score = 41.6 bits (96), Expect = 0.012
 Identities = 22/69 (31%), Positives = 30/69 (43%), Gaps = 6/69 (8%)

Query: 1378 CDMHASCLNIPGSFKCSCREGWIGNGIKCIDL----DECSNGTHQCSINAQCVNTPGSYR 1433
            C    +C+    S  C+C  GW G+   C +     D   +  H CS  A C++ P  Y 
Sbjct: 2619 CGNGGTCIESGTSVYCNCTTGWKGSF--CTETVSTCDPEHDPPHHCSRGATCISLPHGYT 2676

Query: 1434 CACSEGFTG 1442
            C C  G TG
Sbjct: 2677 CFCPLGTTG 2685



 Score = 39.3 bits (90), Expect = 0.057
 Identities = 24/78 (30%), Positives = 35/78 (44%), Gaps = 6/78 (7%)

Query: 1116 IDECRISPDL---CGSG-ICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLC-R 1170
            + +C  SP     CG+G  C+ +  S  C C  G++  F   +     D     P  C R
Sbjct: 2606 VGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCT-ETVSTCDPEHDPPHHCSR 2664

Query: 1171 GGTCVNTEGSFQCDCPLG 1188
            G TC++    + C CPLG
Sbjct: 2665 GATCISLPHGYTCFCPLG 2682



 Score = 38.5 bits (88), Expect = 0.098
 Identities = 29/80 (36%), Positives = 34/80 (42%), Gaps = 9/80 (11%)

Query: 487  GLTILNQTIDICKHHANLCLN-GRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCT 545
            G  I N  +  C HH  LC N G CI    +  CEC   Y    +G       C +NPC 
Sbjct: 2328 GKNIENCHVPWCAHH--LCRNNGTCISDNENLFCECPRLY----SGKLCQFASCENNPCG 2381

Query: 546  NG-DCVNTPGS-YYCKCHAG 563
            NG  CV   G+   C C  G
Sbjct: 2382 NGATCVPKSGTDIVCLCPYG 2401



 Score = 38.5 bits (88), Expect = 0.098
 Identities = 27/87 (31%), Positives = 32/87 (36%), Gaps = 5/87 (5%)

Query: 267  PNIRTGACQDVDECQAIPGICQ----GGNCINTVGSFECRCPAGHKQSETTQKCEDIDEC 322
            P     A + V +C A P        GG CI +  S  C C  G K S  T+     D  
Sbjct: 2596 PEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPE 2655

Query: 323  SIIPGICETG-ECSNTVGSYFCVCPRG 348
               P  C  G  C +    Y C CP G
Sbjct: 2656 HDPPHHCSRGATCISLPHGYTCFCPLG 2682



 Score = 38.5 bits (88), Expect = 0.098
 Identities = 21/64 (32%), Positives = 26/64 (40%), Gaps = 1/64 (1%)

Query: 1819 CANG-VCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCE 1877
            C NG  CI    S  C C TG+  +         D   +  + C R A CI+ P  Y C 
Sbjct: 2619 CGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCF 2678

Query: 1878 CAAG 1881
            C  G
Sbjct: 2679 CPLG 2682



 Score = 37.0 bits (84), Expect = 0.29
 Identities = 28/88 (31%), Positives = 34/88 (38%), Gaps = 14/88 (15%)

Query: 2565 HHTACIDNNECGSQPSL---CGAKGICQNTPGSFSCECQRGFSLDATGLNC-EDVDECDG 2620
            H  A     +C + P     CG  G C  +  S  C C  G+     G  C E V  CD 
Sbjct: 2599 HPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWK----GSFCTETVSTCDP 2654

Query: 2621 N----HRCQHG--CQNILGGYRCGCPQG 2642
                 H C  G  C ++  GY C CP G
Sbjct: 2655 EHDPPHHCSRGATCISLPHGYTCFCPLG 2682



 Score = 37.0 bits (84), Expect = 0.29
 Identities = 21/59 (35%), Positives = 24/59 (40%), Gaps = 1/59 (1%)

Query: 1663 GGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPG-TCYNTLGNYTCICP 1720
            GG CI +  S  C C  G+  S  T      D     P  C  G TC +    YTC CP
Sbjct: 2622 GGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCP 2680



 Score = 37.0 bits (84), Expect = 0.29
 Identities = 24/84 (28%), Positives = 33/84 (39%), Gaps = 5/84 (5%)

Query: 1360 KGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQC 1419
            KG +   D D    G + C     C     +F C C   W GN   C     C N  + C
Sbjct: 2866 KGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGN--TCNQSVSCLN--NLC 2921

Query: 1420 SINAQCV-NTPGSYRCACSEGFTG 1442
               + C+ +   SY C C+ G+ G
Sbjct: 2922 LHQSLCIPDQSFSYSCLCTLGWVG 2945



 Score = 36.2 bits (82), Expect = 0.49
 Identities = 17/63 (26%), Positives = 27/63 (42%)

Query: 1339 GECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREG 1398
            G C  +  S  C+C  G+     T   +  D      H+C   A+C+++P  + C C  G
Sbjct: 2623 GTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLG 2682

Query: 1399 WIG 1401
              G
Sbjct: 2683 TTG 2685



 Score = 36.2 bits (82), Expect = 0.49
 Identities = 22/76 (28%), Positives = 33/76 (43%), Gaps = 7/76 (9%)

Query: 1850 DIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSH-GLC 1908
            D D  + G N C+   +C  +  ++ C C   +       C     CL   N+C H  LC
Sbjct: 2873 DCDGTACGYNTCRNGGECTVNGTTFSCRCLPDW---AGNTCNQSVSCLN--NLCLHQSLC 2927

Query: 1909 V-DLQGSYQCICHNGF 1923
            + D   SY C+C  G+
Sbjct: 2928 IPDQSFSYSCLCTLGW 2943



 Score = 35.8 bits (81), Expect = 0.64
 Identities = 28/73 (38%), Positives = 35/73 (47%), Gaps = 11/73 (15%)

Query: 2183 SNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNG-TCTNVIGS-FECNCN 2240
            +NG CI+ + +  CECP      Y+G  C     C   NPCGNG TC    G+   C C 
Sbjct: 2346 NNGTCISDNENLFCECPR----LYSGKLC-QFASCE-NNPCGNGATCVPKSGTDIVCLCP 2399

Query: 2241 EGFEPGPMMNCED 2253
             G   GP+  C D
Sbjct: 2400 YG-RSGPL--CTD 2409



 Score = 35.8 bits (81), Expect = 0.64
 Identities = 25/83 (30%), Positives = 33/83 (39%), Gaps = 14/83 (16%)

Query: 1495 CSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPIN-----CVNGL-CV 1548
            CS       GTC       +C C  G++    G  CT+     DP +     C  G  C+
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWK----GSFCTETVSTCDPEHDPPHHCSRGATCI 2669

Query: 1549 NTPGRYECNCPPDFQLNPTGVGC 1571
            + P  Y C CP    L  TG+ C
Sbjct: 2670 SLPHGYTCFCP----LGTTGIYC 2688



 Score = 35.0 bits (79), Expect = 1.1
 Identities = 25/77 (32%), Positives = 36/77 (46%), Gaps = 11/77 (14%)

Query: 2019 ECVALPGSC----SPGTCQNLEGSFRCICPPGYEVKSENCID-INECDED---PNICLFG 2070
            +C A P S     + GTC     S  C C  G+  K   C + ++ CD +   P+ C  G
Sbjct: 2608 QCHASPCSLMKCGNGGTCIESGTSVYCNCTTGW--KGSFCTETVSTCDPEHDPPHHCSRG 2665

Query: 2071 S-CTNTPGGFQCLCPPG 2086
            + C + P G+ C CP G
Sbjct: 2666 ATCISLPHGYTCFCPLG 2682



 Score = 34.3 bits (77), Expect = 1.8
 Identities = 29/94 (30%), Positives = 43/94 (45%), Gaps = 15/94 (15%)

Query: 810  DIDECLV----NRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGA 865
            +I+ C V    + L  +NG C +   +  C CP  Y      + C+    CE+NPC NGA
Sbjct: 2330 NIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLY----SGKLCQ-FASCENNPCGNGA 2384

Query: 866  -CRNNLGS-FNCECSPGSKLSSTGLICIDSLKGT 897
             C    G+   C C  G     +G +C D++  T
Sbjct: 2385 TCVPKSGTDIVCLCPYG----RSGPLCTDAINIT 2414



 Score = 34.3 bits (77), Expect = 1.8
 Identities = 19/67 (28%), Positives = 30/67 (44%), Gaps = 3/67 (4%)

Query: 1418 QCSINAQCVNTPGSYRCACSEGFTGDGFT--CSDVDECAENINLCENGQ-CLNVPGAYRC 1474
            +C     C+ +  S  C C+ G+ G   T   S  D   +  + C  G  C+++P  Y C
Sbjct: 2618 KCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTC 2677

Query: 1475 ECEMGFT 1481
             C +G T
Sbjct: 2678 FCPLGTT 2684



 Score = 33.5 bits (75), Expect = 3.2
 Identities = 25/85 (29%), Positives = 35/85 (41%), Gaps = 12/85 (14%)

Query: 766  GRDINECALDPDICANGICEN-----LRGS-YRCNCNSGYEPDASGRNCIDIDECLVNRL 819
            G ++ +C  D   C    C N     + G+ + C C     PD +G  C     CL N  
Sbjct: 2868 GSNVGDC--DGTACGYNTCRNGGECTVNGTTFSCRCL----PDWAGNTCNQSVSCLNNLC 2921

Query: 820  LCDNGLCRNTPGSYSCTCPPGYVFR 844
            L  +    +   SYSC C  G+V R
Sbjct: 2922 LHQSLCIPDQSFSYSCLCTLGWVGR 2946



 Score = 33.1 bits (74), Expect = 4.1
 Identities = 18/77 (23%), Positives = 31/77 (40%), Gaps = 7/77 (9%)

Query: 536  VDECTSNPCT------NGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNG 589
            V +C ++PC+       G C+ +  S YC C  G++ +   +     D        C  G
Sbjct: 2606 VGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRG 2665

Query: 590  -RCVNTDGSFQCICNAG 605
              C++    + C C  G
Sbjct: 2666 ATCISLPHGYTCFCPLG 2682



 Score = 32.7 bits (73), Expect = 5.4
 Identities = 23/80 (28%), Positives = 30/80 (37%), Gaps = 5/80 (6%)

Query: 766  GRDINECALDPDI---CANG-ICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLC 821
            GR + +C   P     C NG  C     S  CNC +G++           D        C
Sbjct: 2603 GRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHC 2662

Query: 822  DNGL-CRNTPGSYSCTCPPG 840
              G  C + P  Y+C CP G
Sbjct: 2663 SRGATCISLPHGYTCFCPLG 2682



 Score = 32.7 bits (73), Expect = 5.4
 Identities = 17/60 (28%), Positives = 27/60 (45%), Gaps = 4/60 (6%)

Query: 508  GRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNP---CTNG-DCVNTPGSYYCKCHAG 563
            G CI + +S  C C  G+K     + +   +   +P   C+ G  C++ P  Y C C  G
Sbjct: 2623 GTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLG 2682



 Score = 32.3 bits (72), Expect = 7.0
 Identities = 21/67 (31%), Positives = 27/67 (40%), Gaps = 8/67 (11%)

Query: 1861 CQRNADCINSPGSYRCECAAGFKLSPNGACVDR-NEC---LEIPNVCSHG-LCVDLQGSY 1915
            C     CI S  S  C C  G+K      C +  + C    + P+ CS G  C+ L   Y
Sbjct: 2619 CGNGGTCIESGTSVYCNCTTGWK---GSFCTETVSTCDPEHDPPHHCSRGATCISLPHGY 2675

Query: 1916 QCICHNG 1922
             C C  G
Sbjct: 2676 TCFCPLG 2682



 Score = 32.0 bits (71), Expect = 9.2
 Identities = 21/76 (27%), Positives = 29/76 (38%), Gaps = 3/76 (3%)

Query: 1906 GLCVDLQGSYQCICHNGFKAS--QDQTMCMDVDECERHPCGNG-TCKNTVGSYNCLCYPG 1962
            G C++   S  C C  G+K S   +     D +    H C  G TC +    Y C C  G
Sbjct: 2623 GTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLG 2682

Query: 1963 FELTHNNDCLDIDECS 1978
                +    L I + S
Sbjct: 2683 TTGIYCEQALSISDPS 2698



 Score = 32.0 bits (71), Expect = 9.2
 Identities = 17/73 (23%), Positives = 32/73 (43%), Gaps = 2/73 (2%)

Query: 1408 DLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLN 1467
            D D  + G + C    +C     ++ C C   + G+  TC+    C  N+ L ++    +
Sbjct: 2873 DCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGN--TCNQSVSCLNNLCLHQSLCIPD 2930

Query: 1468 VPGAYRCECEMGF 1480
               +Y C C +G+
Sbjct: 2931 QSFSYSCLCTLGW 2943



 Score = 32.0 bits (71), Expect = 9.2
 Identities = 19/74 (25%), Positives = 28/74 (37%), Gaps = 6/74 (8%)

Query: 107  GNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDH--- 163
            G  C    CRN            C C      +TC ++S+   +  C++   C  D    
Sbjct: 2876 GTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTC-NQSVSCLNNLCLHQSLCIPDQSFS 2934

Query: 164  --CQCQKGYIGTYC 175
              C C  G++G YC
Sbjct: 2935 YSCLCTLGWVGRYC 2948


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score =  242 bits (617), Expect = 4e-63
 Identities = 252/932 (27%), Positives = 372/932 (39%), Gaps = 206/932 (22%)

Query: 1301 NIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKK 1360
            N    ++ L + G +A ++++  +    CD N       +    +  F  H       + 
Sbjct: 173  NPEDRWKSLHFSGHVAHLELQIRV---RCDENYYSATCNKFCRPRNDFFGHYTCD---QY 226

Query: 1361 GTTGCTDV---DECE--IGAHNCDM-HASCLNIPGSFKCSCREGWIGNGI-KCIDLDECS 1413
            G   C D     EC+  +    C++ H  C  +PG  +C C  GW G    +C+    C 
Sbjct: 227  GNKACMDGWMGKECKEAVCKQGCNLLHGGC-TVPG--ECRCSYGWQGRFCDECVPYPGCV 283

Query: 1414 NGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCS-DVDECAENINLCENGQCLNV-PGA 1471
            +G+        CV     ++C C   +   G  C  D++ C  +      G C+N  P  
Sbjct: 284  HGS--------CVEP---WQCNCETNW--GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQ 330

Query: 1472 YRCECEMGFTPASDSRSCQDIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRTGGNC 1530
            YRC C  G++     R+C+  +     N C  G +C+ +P  F C C  G+    +G  C
Sbjct: 331  YRCTCPDGYS----GRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGW----SGPTC 382

Query: 1531 T-DIDECADPINCVNGLCVNTPGRYECNCPPDF-----QLNPT---GVGCVD-----NRV 1576
              DIDECA       G CV+    +EC CP  +     QL+     G  C++     N +
Sbjct: 383  ALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLI 442

Query: 1577 GNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGG 1636
            G  Y    P   G    N  I V   R  C        G  C+    VN   Y  +CP G
Sbjct: 443  GGYYCDCIP---GWKGINCHINVNDCRGQC------QHGGTCKDL--VNG--YQCVCPRG 489

Query: 1637 EGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICE-DIDE 1695
             G R   +     + DEC   P    GG C +    F C CPQG+       +CE D+D 
Sbjct: 490  FGGRHCEL-----ERDECASSP-CHSGGLCEDLADGFHCHCPQGF----SGPLCEVDVDL 539

Query: 1696 CFAHPGVCGPGT-CYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELP 1754
            C   P  C  G  CYN  G+Y C CP ++    GG NC                      
Sbjct: 540  C--EPSPCRNGARCYNLEGDYYCACPDDF----GGKNC---------------------- 571

Query: 1755 FNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKE 1814
                              + P EPC  PG A     C  I G   D   G          
Sbjct: 572  ------------------SVPREPC--PGGA-----CRVIDGCGSDAGPG---------- 596

Query: 1815 IPGICANGV------CINQI-GSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADC 1867
            +PG  A+GV      C++Q  G+F C C +GF+        E+ID+C      C+    C
Sbjct: 597  MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGT---YCHENIDDCLG--QPCRNGGTC 651

Query: 1868 INSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVC-SHGLCVDLQGSYQCICHNGFKAS 1926
            I+   ++RC C +G++    G   D N    +P+ C S G C DL   + C C +G+K  
Sbjct: 652  IDEVDAFRCFCPSGWE----GELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKG- 706

Query: 1927 QDQTMCMDVDECERHPCGN-GTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVC 1985
              +T      +C+ + C N GTC ++  ++ C C PG++    + C      S       
Sbjct: 707  --KTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWK---GSTCAVAKNSSCLPNPCV 761

Query: 1986 RNGRCFNEIGSFKCLCNEGYELTPDGKNCI-DTNECVALPGSCSPGTCQNLEGSFRCICP 2044
              G C     SF C+C +G+E    G+ C  +TN+C  LP   + G C +    FRC C 
Sbjct: 762  NGGTCVGSGASFSCICRDGWE----GRTCTHNTNDCNPLP-CYNGGICVDGVNWFRCECA 816

Query: 2045 PGYEVKSENC-IDINECDEDPNICLFG-SCTNTPGGFQCLCPPGFV------LSDNGRRC 2096
            PG+     +C I+I+EC   P  C +G +C +   G++C CPPG        +   GR C
Sbjct: 817  PGF--AGPDCRINIDECQSSP--CAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSC 872

Query: 2097 FDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCP 2156
            +     F   +     C+  +  +  +    CSK+   GW  PC L  + + ++ Q  CP
Sbjct: 873  WSRGTPFPHGSSWVEDCNSCRCLDGRRD---CSKV-WCGW-KPCLLAGQPEALSAQ--CP 925

Query: 2157 YGHGTVPSLHDTREDVNECLE-SPGICSNGQC 2187
             G                CLE +PG C    C
Sbjct: 926  LG--------------QRCLEKAPGQCLRPPC 943



 Score =  204 bits (518), Expect = 1e-51
 Identities = 196/723 (27%), Positives = 294/723 (40%), Gaps = 128/723 (17%)

Query: 2060 CDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAF 2119
            C +  N+ L G CT  PG  +C C  G+     GR C    +   +    +G C  P   
Sbjct: 245  CKQGCNL-LHGGCT-VPG--ECRCSYGW----QGRFC---DECVPYPGCVHGSCVEPWQC 293

Query: 2120 N--TTKAKCCCSK-MPGEGWGDPCE---LCPKDDEVAFQDLCPYGHGTVPSLHDTREDVN 2173
            N  T      C K +   G   PC     C   +   ++  CP G+    S  +  +  +
Sbjct: 294  NCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNCEKAEH 349

Query: 2174 ECLESPGICSNG-QCINTDGSFRCECPMGYNLDYTGVRC-VDTDECSIGNPCG-NGTCTN 2230
             C  +P  C+NG  C      F C CP G++    G  C +D DEC+  NPC   GTC +
Sbjct: 350  ACTSNP--CANGGSCHEVPSGFECHCPSGWS----GPTCALDIDECA-SNPCAAGGTCVD 402

Query: 2231 VIGSFECNCNEGFEPGPMMNCE-DINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQ 2289
             +  FEC C E +       C+ D NEC   P L AF C N  G Y C C  G+      
Sbjct: 403  QVDGFECICPEQWVGA---TCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGW------ 453

Query: 2290 KMCKDLDECAEGLHDCESR---GMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECRTK 2345
               K ++ C   ++DC  +   G  CK+L+  + C+CP G      G  C ++ +EC + 
Sbjct: 454  ---KGIN-CHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFG----GRHCELERDECASS 505

Query: 2346 PGICEN-GRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNL 2404
            P  C + G C ++   + C C +GF    SG  C +    LC      + C+  +   NL
Sbjct: 506  P--CHSGGLCEDLADGFHCHCPQGF----SGPLC-EVDVDLC----EPSPCRNGARCYNL 554

Query: 2405 VTKSECCCD---GGRGWGHQCELCP-----------------LPGTAQYKKICPHGPGYT 2444
                 C C    GG+      E CP                 +PGTA      PHG   +
Sbjct: 555  EGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVS 614

Query: 2445 TDG-----------------RDIDECKVMPNLCTN-GQCINTMGSFRCFCKVGYTTDISG 2486
              G                  +ID+C   P  C N G CI+ + +FRCFC  G+  ++  
Sbjct: 615  QPGGNFSCICDSGFTGTYCHENIDDCLGQP--CRNGGTCIDEVDAFRCFCPSGWEGELCD 672

Query: 2487 TSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLD-ECQTKQHNCQF 2545
            T   + ++C   P      C +    + C+C  G+     GKTC   + +C     +   
Sbjct: 673  T---NPNDCLPDPCHSRGRCYDLVNDFYCACDDGW----KGKTCHSREFQCDAYTCSNGG 725

Query: 2546 LCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSL 2605
             C ++   F C CPPG+     A   N+ C   P+ C   G C  +  SFSC C+ G+  
Sbjct: 726  TCYDSGDTFRCACPPGWKGSTCAVAKNSSC--LPNPCVNGGTCVGSGASFSCICRDGWE- 782

Query: 2606 DATGLNC-EDVDECDGNHRCQHG--CQNILGGYRCGCPQGYIQHYQWNQC-VDENECSNP 2661
               G  C  + ++C+    C +G  C + +  +RC C  G    +    C ++ +EC + 
Sbjct: 783  ---GRTCTHNTNDCN-PLPCYNGGICVDGVNWFRCECAPG----FAGPDCRINIDECQSS 834

Query: 2662 NACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGC 2721
                 A+C + +  Y+C+CP G +  +          C S   P  +G S  E    C C
Sbjct: 835  PCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRC 894

Query: 2722 PPG 2724
              G
Sbjct: 895  LDG 897



 Score =  190 bits (483), Expect = 2e-47
 Identities = 212/772 (27%), Positives = 301/772 (38%), Gaps = 160/772 (20%)

Query: 1136 GSFECE------CFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGH 1189
            G + C+      C +G+     M K C +   C++   L  GG  V  E    C C  G 
Sbjct: 219  GHYTCDQYGNKACMDGW-----MGKECKEA-VCKQGCNLLHGGCTVPGE----CRCSYGW 268

Query: 1190 ELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNP---GYQATPDRQGCTDIDEC 1246
            +     ++CV    C        +G CV     +QC+C     G     D   C     C
Sbjct: 269  Q-GRFCDECVPYPGCV-------HGSCVE---PWQCNCETNWGGLLCDKDLNYCGSHHPC 317

Query: 1247 MIMNGGCDTQCTNSE-GSYECSCSEGYALMPDGRSCADIDE-CENNPDICDGGQCTNIPG 1304
               NGG    C N+E   Y C+C +GY+    GR+C   +  C +NP   +GG C  +P 
Sbjct: 318  T--NGGT---CINAEPDQYRCTCPDGYS----GRNCEKAEHACTSNP-CANGGSCHEVPS 367

Query: 1305 EYRCLCYDGFMASMDMKTC-IDVNECDLNSNICMF-GECENTKGSFICHCQLGYSVKKGT 1362
             + C C  G+       TC +D++EC   SN C   G C +    F C C   +    G 
Sbjct: 368  GFECHCPSGWSG----PTCALDIDEC--ASNPCAAGGTCVDQVDGFECICPEQW---VGA 418

Query: 1363 TGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKC-IDLDECSNGTHQCSI 1421
            T   D +ECE     C    SC N+ G + C C  GW   GI C I++++C     QC  
Sbjct: 419  TCQLDANECE--GKPCLNAFSCKNLIGGYYCDCIPGW--KGINCHINVNDCRG---QCQH 471

Query: 1422 NAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFT 1481
               C +    Y+C C  GF G      + DECA +      G C ++   + C C  GF+
Sbjct: 472  GGTCKDLVNGYQCVCPRGFGGRHCEL-ERDECASS-PCHSGGLCEDLADGFHCHCPQGFS 529

Query: 1482 PASDSRSCQ-DIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPI 1540
                   C+ D+D C          C NL G ++C C D    D  G NC+   E     
Sbjct: 530  ----GPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPD----DFGGKNCSVPRE----- 576

Query: 1541 NCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVG 1600
             C  G C    G   C       +  T    V    G C  +  P G+ S  C++    G
Sbjct: 577  PCPGGACRVIDG---CGSDAGPGMPGTAASGVCGPHGRCVSQ--PGGNFSCICDS----G 627

Query: 1601 VSRSSCCCSLGKAWGNPCE---TCPPVNSTE-YYTLCPGG-EGFRPNPITIILEDIDECQ 1655
             + + C  ++    G PC    TC  ++  + +   CP G EG         L D +   
Sbjct: 628  FTGTYCHENIDDCLGQPCRNGGTC--IDEVDAFRCFCPSGWEG--------ELCDTNPND 677

Query: 1656 ELPGLCQG-GNCINTFGSFQCECPQGYYLSEDTRICEDID-ECFAHPGVCGPGTCYNTLG 1713
             LP  C   G C +    F C C  G+      + C   + +C A+    G GTCY++  
Sbjct: 678  CLPDPCHSRGRCYDLVNDFYCACDDGW----KGKTCHSREFQCDAYTCSNG-GTCYDSGD 732

Query: 1714 NYTCICPPEYMQVNGGHNCMDMRKSFCYRS--YNGTTCENELPFNVTKRMCCCTYNVGKA 1771
             + C CPP +     G  C   + S C  +   NG TC                  VG  
Sbjct: 733  TFRCACPPGWK----GSTCAVAKNSSCLPNPCVNGGTC------------------VGSG 770

Query: 1772 WNKPCEPCPTPGTADFKTIC-GNIPGFTFDIHTGKAVDIDECKEIPGICAN-GVCINQIG 1829
                         A F  IC     G T   +T      ++C  +P  C N G+C++ + 
Sbjct: 771  -------------ASFSCICRDGWEGRTCTHNT------NDCNPLP--CYNGGICVDGVN 809

Query: 1830 SFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAG 1881
             FRCEC  GF+  D  +   +IDEC +    C   A C++    YRC C  G
Sbjct: 810  WFRCECAPGFAGPDCRI---NIDECQSSP--CAYGATCVDEINGYRCSCPPG 856



 Score =  187 bits (475), Expect = 1e-46
 Identities = 186/697 (26%), Positives = 266/697 (38%), Gaps = 147/697 (21%)

Query: 695  RVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYG-FGEPCQPCPAKNSAEFH 753
            + C+D  M   C   + K  C     G     EC C+    G F + C P P       H
Sbjct: 229  KACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGC----VH 284

Query: 754  GLC---------SSGVGITVDGRDINECALDPDICANGICENLR-GSYRCNCNSGYEPDA 803
            G C         ++  G+  D +D+N C         G C N     YRC C  GY    
Sbjct: 285  GSCVEPWQCNCETNWGGLLCD-KDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY---- 339

Query: 804  SGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT------------------ 845
            SGRNC   +    +    + G C   P  + C CP G+   T                  
Sbjct: 340  SGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGT 399

Query: 846  ----------------ETETCE-DINECESNPCVNG-ACRNNLGSFNCECSPGSKLSSTG 887
                               TC+ D NECE  PC+N  +C+N +G + C+C PG K    G
Sbjct: 400  CVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWK----G 455

Query: 888  LIC---IDSLKGTCWLNIQDSRCEVNING-------------ATLKSECCATLGAAWGSP 931
            + C   ++  +G C        C+  +NG               L+ + CA+     G  
Sbjct: 456  INCHINVNDCRGQCQ---HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGL 512

Query: 932  CERCE--LDTACPRGLARIKGVTCE-DVNECEVFPGVCPNG-RCVNSKGSFHCECPEGLT 987
            CE         CP+G +   G  CE DV+ CE  P  C NG RC N +G ++C CP+   
Sbjct: 513  CEDLADGFHCHCPQGFS---GPLCEVDVDLCE--PSPCRNGARCYNLEGDYYCACPD--- 564

Query: 988  LDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKE 1047
             D  G+ C   R               P PG        C V    G++      PGT  
Sbjct: 565  -DFGGKNCSVPR--------------EPCPGG------ACRVIDGCGSDAGP-GMPGTAA 602

Query: 1048 YETLCPRGAGFANRG--------DVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCR 1099
                 P G   +  G           TG   +++I++C   P     G C + + +F+C 
Sbjct: 603  SGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQP-CRNGGTCIDEVDAFRCF 661

Query: 1100 CNSGFALDMEERNCTDIDECRISPDLCGS-GICVNTPGSFECECFEGYESGFMMMKNCMD 1158
            C SG+  ++ + N  D       PD C S G C +    F C C +G++      K C  
Sbjct: 662  CPSGWEGELCDTNPND-----CLPDPCHSRGRCYDLVNDFYCACDDGWKG-----KTCHS 711

Query: 1159 IDECERNPLLC-RGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRN-GKC 1216
              E + +   C  GGTC ++  +F+C CP G + S     C      S   N C N G C
Sbjct: 712  -REFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGS----TCAVAKNSSCLPNPCVNGGTC 766

Query: 1217 VNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMP 1276
            V    ++ C C  G++         D +     NGG    C +    + C C+ G+A  P
Sbjct: 767  VGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGI---CVDGVNWFRCECAPGFA-GP 822

Query: 1277 DGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDG 1313
            D R   +IDEC+++P    G  C +    YRC C  G
Sbjct: 823  DCR--INIDECQSSP-CAYGATCVDEINGYRCSCPPG 856



 Score =  185 bits (470), Expect = 5e-46
 Identities = 170/579 (29%), Positives = 236/579 (40%), Gaps = 136/579 (23%)

Query: 2173 NECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRC-VDTDECSIGNPCGNG-TCTN 2230
            +EC+  PG C +G C+     ++C C   +     G+ C  D + C   +PC NG TC N
Sbjct: 274  DECVPYPG-CVHGSCVEP---WQCNCETNWG----GLLCDKDLNYCGSHHPCTNGGTCIN 325

Query: 2231 VI-GSFECNCNEGFEPGPMMNCEDINE-CAQNPLLCAFRCMNTFGSYECTCPIGYALRED 2288
                 + C C +G+      NCE     C  NP      C      +EC CP G++    
Sbjct: 326  AEPDQYRCTCPDGYSG---RNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWS---G 379

Query: 2289 QKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECRTKPG 2347
                 D+DECA   + C + G  C + +  F CICP        G  C +D NEC  KP 
Sbjct: 380  PTCALDIDECAS--NPCAAGGT-CVDQVDGFECICPEQWV----GATCQLDANECEGKP- 431

Query: 2348 ICENG-RCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVT 2406
             C N   C N+IG Y C+C  G++    G  C  N    C  +     CQ   + ++LV 
Sbjct: 432  -CLNAFSCKNLIGGYYCDCIPGWK----GINCHINVND-CRGQ-----CQHGGTCKDLVN 480

Query: 2407 KSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLC-TNGQC 2465
                        G+QC             +CP G G      + DEC   P  C + G C
Sbjct: 481  ------------GYQC-------------VCPRGFGGRHCELERDECASSP--CHSGGLC 513

Query: 2466 INTMGSFRCFCKVGYTTDISGTSC-IDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQ 2524
             +    F C C  G+    SG  C +D+D C  SP      C N EG Y C+CP  +   
Sbjct: 514  EDLADGFHCHCPQGF----SGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDF--- 566

Query: 2525 EDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPS---- 2580
              GK C    E                      CP G      AC   + CGS       
Sbjct: 567  -GGKNCSVPRE---------------------PCPGG------ACRVIDGCGSDAGPGMP 598

Query: 2581 ------LCGAKGICQNTPG-SFSCECQRGFSLDATGLNC-EDVDECDGNHRCQHG--CQN 2630
                  +CG  G C + PG +FSC C  GF    TG  C E++D+C G   C++G  C +
Sbjct: 599  GTAASGVCGPHGRCVSQPGGNFSCICDSGF----TGTYCHENIDDCLGQP-CRNGGTCID 653

Query: 2631 ILGGYRCGCPQGYIQHYQWNQC-VDENECSNPNACGSAS-CYNTLGSYKCACPSGFSFDQ 2688
             +  +RC CP G+    +   C  + N+C  P+ C S   CY+ +  + CAC  G+    
Sbjct: 654  EVDAFRCFCPSGW----EGELCDTNPNDCL-PDPCHSRGRCYDLVNDFYCACDDGWK--- 705

Query: 2689 FSSACHDVNECSSSKNPCNYG--CSNTEGGYLCGCPPGY 2725
                CH   E       C+ G  C ++   + C CPPG+
Sbjct: 706  -GKTCHS-REFQCDAYTCSNGGTCYDSGDTFRCACPPGW 742



 Score =  182 bits (463), Expect = 3e-45
 Identities = 197/750 (26%), Positives = 293/750 (39%), Gaps = 162/750 (21%)

Query: 1670 FGSFQCE------CPQGYYLSE-DTRICEDIDEC-FAHPGVCGPGTC---YNTLGNYTCI 1718
            FG + C+      C  G+   E    +C+    C   H G   PG C   Y   G +   
Sbjct: 218  FGHYTCDQYGNKACMDGWMGKECKEAVCKQ--GCNLLHGGCTVPGECRCSYGWQGRFCDE 275

Query: 1719 CPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEP 1778
            C P    V+G  +C++  +  C  ++ G  C+ +L +       C +++          P
Sbjct: 276  CVPYPGCVHG--SCVEPWQCNCETNWGGLLCDKDLNY-------CGSHH----------P 316

Query: 1779 CPTPGTA------DFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGS-F 1831
            C   GT        ++  C        D ++G+  +  E       CANG   +++ S F
Sbjct: 317  CTNGGTCINAEPDQYRCTCP-------DGYSGRNCEKAEHACTSNPCANGGSCHEVPSGF 369

Query: 1832 RCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGAC- 1890
             C CP+G+S     L   DIDEC++  N C     C++    + C C   +       C 
Sbjct: 370  ECHCPSGWSGPTCAL---DIDECAS--NPCAAGGTCVDQVDGFECICPEQWV---GATCQ 421

Query: 1891 VDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKN 1950
            +D NEC   P + +   C +L G Y C C  G+K        ++V++C       GTCK+
Sbjct: 422  LDANECEGKPCLNAFS-CKNLIGGYYCDCIPGWKGINCH---INVNDCRGQCQHGGTCKD 477

Query: 1951 TVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRN-GRCFNEIGSFKCLCNEGYELTP 2009
             V  Y C+C  GF   H    L+ DEC+S     C + G C +    F C C +G+    
Sbjct: 478  LVNGYQCVCPRGFGGRHCE--LERDECAS---SPCHSGGLCEDLADGFHCHCPQGF---- 528

Query: 2010 DGKNC-IDTNECVALPGSCSPGT-CQNLEGSFRCICPPGYEVKSEN----------CIDI 2057
             G  C +D + C   P  C  G  C NLEG + C CP  +  K+ +          C  I
Sbjct: 529  SGPLCEVDVDLCE--PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVI 586

Query: 2058 NECDED----------PNIC-LFGSCTNTPGG-FQCLCPPGFVLSDNGRRCFDTRQSFCF 2105
            + C  D            +C   G C + PGG F C+C  GF              ++C 
Sbjct: 587  DGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFT------------GTYCH 634

Query: 2106 TNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSL 2165
             N ++                 C   P    G  C     D+  AF+  CP   G    L
Sbjct: 635  ENIDD-----------------CLGQPCRN-GGTC----IDEVDAFRCFCP--SGWEGEL 670

Query: 2166 HDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTD-ECSIGNPCG 2224
             DT  + N+CL  P   S G+C +    F C C  G+     G  C   + +C       
Sbjct: 671  CDT--NPNDCLPDP-CHSRGRCYDLVNDFYCACDDGWK----GKTCHSREFQCDAYTCSN 723

Query: 2225 NGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYA 2284
             GTC +   +F C C  G++ G        + C  NP +    C+ +  S+ C C  G+ 
Sbjct: 724  GGTCYDSGDTFRCACPPGWK-GSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE 782

Query: 2285 LREDQKMCKDLDECAEGLHDCES----RGMMCKNLIGTFMCICPPGMARRPDGEGC-VDE 2339
             R           C    +DC       G +C + +  F C C PG A    G  C ++ 
Sbjct: 783  GR----------TCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFA----GPDCRINI 828

Query: 2340 NECRTKPGICENG-RCVNIIGSYRCECNEG 2368
            +EC++ P  C  G  CV+ I  YRC C  G
Sbjct: 829  DECQSSP--CAYGATCVDEINGYRCSCPPG 856



 Score =  179 bits (453), Expect = 5e-44
 Identities = 195/717 (27%), Positives = 280/717 (39%), Gaps = 180/717 (25%)

Query: 640  KCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPP---GLAVGMDGRV 696
            +C C  G+     GR+C   DEC     C++G C+     ++C+C     GL    D   
Sbjct: 261  ECRCSYGW----QGRFC---DECVPYPGCVHGSCVEP---WQCNCETNWGGLLCDKDLNY 310

Query: 697  CVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 756
            C   H    C  G   G C+   P    +  C C  PD   G  C+              
Sbjct: 311  CGSHH---PCTNG---GTCINAEPD---QYRCTC--PDGYSGRNCEKAE----------- 348

Query: 757  SSGVGITVDGRDINECALDPDICANG-ICENLRGSYRCNCNSGYEPDASGRNC-IDIDEC 814
                         + C  +P  CANG  C  +   + C+C SG+    SG  C +DIDEC
Sbjct: 349  -------------HACTSNP--CANGGSCHEVPSGFECHCPSGW----SGPTCALDIDEC 389

Query: 815  LVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCE-DINECESNPCVNG-ACRNNLGS 872
              N      G C +    + C CP  +V      TC+ D NECE  PC+N  +C+N +G 
Sbjct: 390  ASNPCAA-GGTCVDQVDGFECICPEQWV----GATCQLDANECEGKPCLNAFSCKNLIGG 444

Query: 873  FNCECSPGSKLSSTGLIC---IDSLKGTCWLNIQDSRCEVNING-------------ATL 916
            + C+C PG K    G+ C   ++  +G C        C+  +NG               L
Sbjct: 445  YYCDCIPGWK----GINCHINVNDCRGQCQ---HGGTCKDLVNGYQCVCPRGFGGRHCEL 497

Query: 917  KSECCATLGAAWGSPCERCE--LDTACPRGLARIKGVTCE-DVNECEVFPGVCPNG-RCV 972
            + + CA+     G  CE         CP+G +   G  CE DV+ CE  P  C NG RC 
Sbjct: 498  ERDECASSPCHSGGLCEDLADGFHCHCPQGFS---GPLCEVDVDLCE--PSPCRNGARCY 552

Query: 973  NSKGSFHCECPEGLTLDGTGRVCLDIRMEQCY-------------------------LKW 1007
            N +G ++C CP+    D  G+ C  +  E C                          +  
Sbjct: 553  NLEGDYYCACPD----DFGGKNC-SVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCG 607

Query: 1008 DEDECIHPVPGKFRMDACCCAVGAAWGTECEE---------CPKPGT-----KEYETLCP 1053
                C+    G F   +C C  G   GT C E         C   GT       +   CP
Sbjct: 608  PHGRCVSQPGGNF---SCICDSGFT-GTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCP 663

Query: 1054 RGAGFANRGDVLTGRPFYKDINECKAFPGMC-TYGKCRNTIGSFKCRCNSGFALDMEERN 1112
             G      G++    P     N+C   P  C + G+C + +  F C C+ G+    + + 
Sbjct: 664  SGW----EGELCDTNP-----NDC--LPDPCHSRGRCYDLVNDFYCACDDGW----KGKT 708

Query: 1113 CTDIDECRISPDLCGSGICVNTPGSFECECFEGYE-SGFMMMKNCMDIDECERNPLLCRG 1171
            C   +    +      G C ++  +F C C  G++ S   + KN      C  NP +  G
Sbjct: 709  CHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKN----SSCLPNPCV-NG 763

Query: 1172 GTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGK-CVNMIGTYQCSCNPG 1230
            GTCV +  SF C C  G E    R    + N+C+     C NG  CV+ +  ++C C PG
Sbjct: 764  GTCVGSGASFSCICRDGWE---GRTCTHNTNDCNPLP--CYNGGICVDGVNWFRCECAPG 818

Query: 1231 YQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYA------LMPDGRSC 1281
            + A PD +   +IDEC          C +    Y CSC  G A      ++  GRSC
Sbjct: 819  F-AGPDCR--INIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSC 872



 Score =  173 bits (439), Expect = 2e-42
 Identities = 183/687 (26%), Positives = 268/687 (39%), Gaps = 129/687 (18%)

Query: 85  GPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCG--DGFCSRPNMCTCSSGQISSTCG 142
           G   C    +  C  GW     G +C   +C+  C    G C+ P  C CS G     C 
Sbjct: 219 GHYTCDQYGNKACMDGWM----GKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFC- 273

Query: 143 SKSIQQCSVR--CMNGGTCADDHCQCQKGYIGTYCGQPVCENG----CQNGGRCIGPN-- 194
                +C     C++G       C C+  + G  C + +   G    C NGG CI     
Sbjct: 274 ----DECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPD 329

Query: 195 --RCACVYGFTGPQCERDYR---TGPCFTQVNNQMCQGQLTGIVC------TKTLCCATI 243
             RC C  G++G  CE+      + PC    N   C    +G  C      +   C   I
Sbjct: 330 QYRCTCPDGYSGRNCEKAEHACTSNPC---ANGGSCHEVPSGFECHCPSGWSGPTCALDI 386

Query: 244 GRAWGHPCEM---CPAQPQPCRRGF---IPNIRTGA-CQ-DVDECQAIPGICQGGNCINT 295
                +PC     C  Q      GF    P    GA CQ D +EC+  P +    +C N 
Sbjct: 387 DECASNPCAAGGTCVDQVD----GFECICPEQWVGATCQLDANECEGKPCL-NAFSCKNL 441

Query: 296 VGSFECRCPAGHKQSETTQKCE-DIDECSIIPGICETG-ECSNTVGSYFCVCPRGYVTST 353
           +G + C C  G K       C  ++++C    G C+ G  C + V  Y CVCPRG+    
Sbjct: 442 IGGYYCDCIPGWKGIN----CHINVNDCR---GQCQHGGTCKDLVNGYQCVCPRGF---- 490

Query: 354 DGSRCIDQR----TGMCFSG-----LVNG---RCAQELPGRMTKMQC-CCEPG------R 394
            G  C  +R    +  C SG     L +G    C Q   G + ++    CEP       R
Sbjct: 491 GGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGAR 550

Query: 395 CWGI-GTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTG---GNGFAPSGNGNG 450
           C+ + G    ACP    +   + C   +P    PG A     G G   G G   +     
Sbjct: 551 CYNLEGDYYCACP---DDFGGKNC--SVPREPCPGGACRVIDGCGSDAGPGMPGTAASGV 605

Query: 451 YGPGGTGFIPIPGGN-------GFSPGVGGAGVGAGGQGPIITGLTILNQTI-------- 495
            GP G   +  PGGN       GF+       +      P   G T +++          
Sbjct: 606 CGPHGR-CVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPS 664

Query: 496 ----DICKHHANLCL------NGRCIPTVSSYRCECNMGYKQDANGDCIDVD-ECTSNPC 544
               ++C  + N CL       GRC   V+ + C C+ G+K      C   + +C +  C
Sbjct: 665 GWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKT---CHSREFQCDAYTC 721

Query: 545 TNGD-CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICN 603
           +NG  C ++  ++ C C  G++ +    A      C+ N  +   G CV +  SF CIC 
Sbjct: 722 SNGGTCYDSGDTFRCACPPGWKGSTC--AVAKNSSCLPNPCV-NGGTCVGSGASFSCICR 778

Query: 604 AGFELTTDGKNCVDHDECTTTNMCLNG-MCINEDGSFKCICKPGFVLAPNGRYCTDVDEC 662
            G+E    G+ C  +        C NG +C++    F+C C PGF   P+ R   ++DEC
Sbjct: 779 DGWE----GRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFA-GPDCRI--NIDEC 831

Query: 663 QTPGICMNGHCINSEGSFRCDCPPGLA 689
           Q+        C++    +RC CPPG A
Sbjct: 832 QSSPCAYGATCVDEINGYRCSCPPGRA 858



 Score =  145 bits (366), Expect = 6e-34
 Identities = 115/391 (29%), Positives = 170/391 (43%), Gaps = 61/391 (15%)

Query: 2356 NIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRN--LVTKSECCCD 2413
            +  G Y C+             C+D   G    E  + +C+   +  +       EC C 
Sbjct: 216  DFFGHYTCD-------QYGNKACMDGWMG---KECKEAVCKQGCNLLHGGCTVPGECRCS 265

Query: 2414 GGRGW-GHQCELC-PLPGTAQYKKI------CPHGPGYTTDGRDIDECKVMPNLCTNG-Q 2464
               GW G  C+ C P PG      +      C    G     +D++ C    + CTNG  
Sbjct: 266  --YGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCG-SHHPCTNGGT 322

Query: 2465 CINTM-GSFRCFCKVGYTTDISGTSCIDLDE-CSQSPKPCNYICKNTEGSYQCSCPRGYV 2522
            CIN     +RC C  GY    SG +C   +  C+ +P      C      ++C CP G+ 
Sbjct: 323  CINAEPDQYRCTCPDGY----SGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGW- 377

Query: 2523 LQEDGKTCK-DLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSL 2581
                G TC  D+DEC +        CV+ + GF C CP  +    T  +D NEC  +P L
Sbjct: 378  ---SGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGA-TCQLDANECEGKPCL 433

Query: 2582 CGAKGICQNTPGSFSCECQRGFSLDATGLNCE-DVDECDGNHRCQHG--CQNILGGYRCG 2638
                  C+N  G + C+C  G+     G+NC  +V++C G  +CQHG  C++++ GY+C 
Sbjct: 434  NAFS--CKNLIGGYYCDCIPGWK----GINCHINVNDCRG--QCQHGGTCKDLVNGYQCV 485

Query: 2639 CPQGYIQHYQWNQC-VDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACH-DV 2696
            CP+G+   +    C ++ +EC++        C +    + C CP GFS       C  DV
Sbjct: 486  CPRGFGGRH----CELERDECASSPCHSGGLCEDLADGFHCHCPQGFS----GPLCEVDV 537

Query: 2697 NECSSSKNPCNYG--CSNTEGGYLCGCPPGY 2725
            + C  S  PC  G  C N EG Y C CP  +
Sbjct: 538  DLCEPS--PCRNGARCYNLEGDYYCACPDDF 566



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 38/133 (28%), Positives = 50/133 (37%), Gaps = 14/133 (10%)

Query: 90  GSRFHSYCCPGWK----TLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKS 145
           G  F   C PGWK     +   + C+   C N            C C  G    TC   +
Sbjct: 731 GDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNT 790

Query: 146 IQQCSVRCMNGGTCADD----HCQCQKGYIGTYCGQPVCE---NGCQNGGRC---IGPNR 195
                + C NGG C D      C+C  G+ G  C   + E   + C  G  C   I   R
Sbjct: 791 NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYR 850

Query: 196 CACVYGFTGPQCE 208
           C+C  G  GP+C+
Sbjct: 851 CSCPPGRAGPRCQ 863


>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
          Length = 683

 Score =  235 bits (600), Expect = 4e-61
 Identities = 139/401 (34%), Positives = 204/401 (50%), Gaps = 45/401 (11%)

Query: 1131 CVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCR-GGTCVNTEGSFQCD----C 1185
            C +T     C CF GY+       +C D++EC      CR G +C+NT GSF+C     C
Sbjct: 190  CRDTGDEVVCSCFVGYQL-LSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248

Query: 1186 PLGHELSPSREDCVDINECSLSDNLCR-NGKCVNMIGTYQC----SCNPGYQATPDRQG- 1239
              G+EL+     C DI+EC    + C  +  C N +G+++C     C  G+    D  G 
Sbjct: 249  GTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF--IQDALGN 305

Query: 1240 CTDIDECMIMNGGCDT--QCTNSEGSYEC-----SCSEGYALMPDGRSCADIDECENNPD 1292
            C DI+EC+ ++  C     C N+EGSY C     +C  GY L  +G  C D+DEC    +
Sbjct: 306  CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAE 365

Query: 1293 ICDGG-QCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICH 1351
             C  G +C N PG +RC C  G+      + C+DVNEC          +CENT GS++C 
Sbjct: 366  PCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCS 425

Query: 1352 CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW---IGNGIKCID 1408
            C +G+ +      C D++EC     +      C N+ GS++C CR G+     +G+ C D
Sbjct: 426  CSVGFRLSVDGRSCEDINECS----SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481

Query: 1409 LDECS--NGTHQCSINAQCVNTPGSYRCAC-SEGF--TGDGFTCSDVDECAENINLCE-N 1462
            +DEC+   G H CS   +C+N PGS++C+C S G+    +G  C D+DEC   I+ C  N
Sbjct: 482  IDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539

Query: 1463 GQCLNVPGAYRC---ECEMGFTPASDSR----SCQDIDECS 1496
              C N+ G +RC   EC   +  ++ +R     C +  ECS
Sbjct: 540  ETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS 580



 Score =  224 bits (570), Expect = 1e-57
 Identities = 148/441 (33%), Positives = 199/441 (45%), Gaps = 70/441 (15%)

Query: 2215 DECSIGNPCGNGTCTNVIGSFECNCNEGFEP-GPMMNCEDINECAQNPLLCAF--RCMNT 2271
            D C  G PC    C +      C+C  G++     ++CED+NEC      C     C+NT
Sbjct: 178  DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 2272 FGSYEC----TCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI----C 2323
             GS+ C    +C  GY L ED   CKD+DEC  G+H+C     +C+N +G+F C     C
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLP-DFICQNTLGSFRCRPKLQC 294

Query: 2324 PPGMARRPDGEGCVDENECRTKPGICENGR-CVNIIGSYRCE-----CNEGFQSSSSGTE 2377
              G  +   G  C+D NEC +    C  G  C+N  GSY C+     C  G+  +  GT 
Sbjct: 295  KSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353

Query: 2378 CLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKIC 2437
            C+D  +                        +E C     G GH+C     PG+ +    C
Sbjct: 354  CVDVDE--------------------CAPPAEPC-----GKGHRC--VNSPGSFR----C 382

Query: 2438 PHGPGYTTDGR-----DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDL 2492
                GY  DG      D++EC+  P      +C NT+GS+ C C VG+   + G SC D+
Sbjct: 383  ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI 442

Query: 2493 DECSQSPKPCNYICKNTEGSYQCSCPRGYVLQE-DGKTCKDLDEC--QTKQHNCQFLCVN 2549
            +ECS S  PC+  C N  GSYQC C RGY L + DG TC+D+DEC   T  H C + C+N
Sbjct: 443  NECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCIN 500

Query: 2550 TLGGFTCKCPPG---FTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSC---ECQRGF 2603
              G F C CP        +   C D +EC +    C     C N  G F C   EC   +
Sbjct: 501  IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560

Query: 2604 SLDATGLNCEDVDECDGNHRC 2624
               A    CE +  C  N  C
Sbjct: 561  RRSA-ATRCERL-PCHENREC 579



 Score =  214 bits (545), Expect = 1e-54
 Identities = 140/399 (35%), Positives = 186/399 (46%), Gaps = 57/399 (14%)

Query: 2363 CECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQC 2422
            C C  G+Q  S G  C D  + +  +      C++  S  N V    C  D   G G++ 
Sbjct: 199  CSCFVGYQLLSDGVSCEDVNECITGSHS----CRLGESCINTVGSFRCQRDSSCGTGYEL 254

Query: 2423 ELCPLPGTAQYKKICPHGPGYTTDG--RDIDECKV-MPNLCTNGQCINTMGSFRCF---- 2475
                                 T D   +DIDEC+  + N   +  C NT+GSFRC     
Sbjct: 255  ---------------------TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQ 293

Query: 2476 CKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQC-----SCPRGYVLQEDGK 2528
            CK G+  D  G +CID++EC     PC   + C NTEGSY C     +C RGY L E+G 
Sbjct: 294  CKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT 352

Query: 2529 TCKDLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG--FTQHHTACIDNNECGSQPS-LCG 2583
             C D+DEC      C     CVN+ G F C+C  G  F      C+D NEC   P  LCG
Sbjct: 353  RCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG 412

Query: 2584 AKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGY 2643
             K  C+NT GS+ C C  GF L   G +CED++EC  +  C   C N+ G Y+C C +GY
Sbjct: 413  HK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP-CSQECANVYGSYQCYCRRGY 469

Query: 2644 -IQHYQWNQCVDENECSNPNACGSAS--CYNTLGSYKCACPS-GFSFDQFSSACHDVNEC 2699
             +       C D +EC+ P      S  C N  GS++C+CPS G+        C D++EC
Sbjct: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 2700 SSSKNPC--NYGCSNTEGGYLC---GCPPGYYRVGQGHC 2733
             +  + C  N  C N +GG+ C    CP  Y R     C
Sbjct: 530  VTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRC 568



 Score =  207 bits (528), Expect = 9e-53
 Identities = 177/614 (28%), Positives = 242/614 (39%), Gaps = 122/614 (19%)

Query: 1166 PLLCRGGTC-----VNTEGSFQCDCPLGHELSPSREDC-----VDINECSLSDNLCRNGK 1215
            PLL  GG       V+ +   +  C  GH ++  ++DC      +  EC +    C    
Sbjct: 13   PLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQC---- 68

Query: 1216 CVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNG-GCDTQCTNSEGSYECSCSEGYAL 1274
            C + +    C+         DR        C   +G     + T  +    C C  G A 
Sbjct: 69   CHSQLEELHCATGISLANEQDR--------CATPHGDNASLEATFVKRCCHC-CLLGRAA 119

Query: 1275 MPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYD---------GFMASMDMKTCID 1325
               G+SC           +  G QC  +   +R  C           G +   D    ++
Sbjct: 120  QAQGQSC--------EYSLMVGYQCGQV---FRACCVKSQETGDLDVGGLQETDKIIEVE 168

Query: 1326 VNECD--LNSNICMFG-----ECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNC 1378
              + D  LN   C  G     +C +T    +C C +GY +      C DV+EC  G+H+C
Sbjct: 169  EEQEDPYLNDR-CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227

Query: 1379 DMHASCLNIPGSFKC----SCREGW-IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYR 1433
             +  SC+N  GSF+C    SC  G+ +     C D+DEC +G H C  +  C NT GS+R
Sbjct: 228  RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFR 287

Query: 1434 C----ACSEGFTGDGF-TCSDVDECAENINLCENGQ-CLNVPGAYRCE-----CEMGFTP 1482
            C     C  GF  D    C D++EC      C  G  C+N  G+Y C+     C  G+  
Sbjct: 288  CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL 347

Query: 1483 ASDSRSCQDIDECS-FQNICVFG-TCNNLPGMFHCICDDGYELDRTGGNCTDIDECAD-P 1539
              +   C D+DEC+     C  G  C N PG F C C  GY  D     C D++EC   P
Sbjct: 348  NEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYP 407

Query: 1540 INCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGV 1599
                   C NT G Y C+C   F+L+  G  C D  +  C          S  C+ E   
Sbjct: 408  GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED--INEC---------SSSPCSQECAN 456

Query: 1600 GVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPG 1659
                  C C  G                  Y L         +   +  EDIDEC     
Sbjct: 457  VYGSYQCYCRRG------------------YQL--------SDVDGVTCEDIDEC----A 486

Query: 1660 LCQGGN-----CINTFGSFQCECP-QGYYLSEDTRICEDIDECFAHPGVCGPG-TCYNTL 1712
            L  GG+     CIN  GSFQC CP  GY L+ + R C+DIDEC      C    TC+N  
Sbjct: 487  LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQ 546

Query: 1713 GNYTCI---CPPEY 1723
            G + C+   CP  Y
Sbjct: 547  GGFRCLAFECPENY 560



 Score =  204 bits (518), Expect = 1e-51
 Identities = 120/284 (42%), Positives = 143/284 (50%), Gaps = 25/284 (8%)

Query: 2464 QCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNY--ICKNTEGSYQC----SC 2517
            QC +T     C C VGY     G SC D++EC      C     C NT GS++C    SC
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248

Query: 2518 PRGYVLQEDGKTCKDLDECQTKQHNC--QFLCVNTLGGFTCK----CPPGFTQHHTA-CI 2570
              GY L ED  +CKD+DEC++  HNC   F+C NTLG F C+    C  GF Q     CI
Sbjct: 249  GTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCI 307

Query: 2571 DNNECGSQPSLCGAKGICQNTPGSFSCE-----CQRGFSLDATGLNCEDVDEC-DGNHRC 2624
            D NEC S  + C     C NT GS++C+     C RG+ L+  G  C DVDEC      C
Sbjct: 308  DINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367

Query: 2625 Q--HGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSN-PNACGSASCYNTLGSYKCACP 2681
               H C N  G +RC C  GY        CVD NEC   P       C NTLGSY C+C 
Sbjct: 368  GKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCS 427

Query: 2682 SGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGY 2725
             GF       +C D+NECSSS  PC+  C+N  G Y C C  GY
Sbjct: 428  VGFRLSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGY 469



 Score =  196 bits (499), Expect = 2e-49
 Identities = 136/449 (30%), Positives = 196/449 (43%), Gaps = 71/449 (15%)

Query: 2287 EDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKP 2346
            E+++    L++   G   C+ +   C++     +C C  G     DG  C D NEC T  
Sbjct: 168  EEEQEDPYLNDRCRGGGPCKQQ---CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGS 224

Query: 2347 GICENGR-CVNIIGSYRCE----CNEGFQ-SSSSGTECLDNRQGLCFAEVLQTICQMASS 2400
              C  G  C+N +GS+RC+    C  G++ +  +  + +D  +      +   ICQ    
Sbjct: 225  HSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLG 284

Query: 2401 SRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR----DIDECKVM 2456
            S     K +C                               G+  D      DI+EC  +
Sbjct: 285  SFRCRPKLQC-----------------------------KSGFIQDALGNCIDINECLSI 315

Query: 2457 PNLCTNGQ-CINTMGSFRCF-----CKVGYTTDISGTSCIDLDECSQSPKPCN--YICKN 2508
               C  G  CINT GS+ C      C  GY  +  GT C+D+DEC+   +PC   + C N
Sbjct: 316  SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375

Query: 2509 TEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHN-CQFLCVNTLGGFTCKCPPGF--TQH 2565
            + GS++C C  GY      + C D++ECQ      C   C NTLG + C C  GF  +  
Sbjct: 376  SPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVD 435

Query: 2566 HTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSL-DATGLNCEDVDEC---DGN 2621
              +C D NEC S P  C  +  C N  GS+ C C+RG+ L D  G+ CED+DEC    G 
Sbjct: 436  GRSCEDINECSSSP--CSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 491

Query: 2622 HRCQHGCQNILGGYRCGCP-QGYIQHYQWNQCVDENECSN--PNACGSASCYNTLGSYKC 2678
            H C + C NI G ++C CP  GY        C D +EC     N   + +C+N  G ++C
Sbjct: 492  HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551

Query: 2679 ---ACPSGFSFDQFSSA----CHDVNECS 2700
                CP  +     +      CH+  ECS
Sbjct: 552  LAFECPENYRRSAATRCERLPCHENRECS 580



 Score =  196 bits (497), Expect = 4e-49
 Identities = 123/364 (33%), Positives = 169/364 (46%), Gaps = 48/364 (13%)

Query: 2412 CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYT--TDG---RDIDECKVMPNLCTNGQ-C 2465
            C GG     QC           + +C    GY   +DG    D++EC    + C  G+ C
Sbjct: 180  CRGGGPCKQQCR------DTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESC 233

Query: 2466 INTMGSFRC----FCKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQC---- 2515
            INT+GSFRC     C  GY       SC D+DEC      C  ++IC+NT GS++C    
Sbjct: 234  INTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292

Query: 2516 SCPRGYVLQEDGKTCKDLDECQTKQHNCQF--LCVNTLGGFTCK-----CPPGF--TQHH 2566
             C  G++    G  C D++EC +    C     C+NT G +TC+     C  G+   +  
Sbjct: 293  QCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351

Query: 2567 TACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDG--NHRC 2624
            T C+D +EC      CG    C N+PGSF CEC+ G+  D     C DV+EC       C
Sbjct: 352  TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411

Query: 2625 QHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGF 2684
             H C+N LG Y C C  G+        C D NECS+ + C S  C N  GSY+C C  G+
Sbjct: 412  GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-SPC-SQECANVYGSYQCYCRRGY 469

Query: 2685 SFDQFSSA-CHDVNECS--SSKNPCNYGCSNTEGGYLCGCPPGYYRVGQG--------HC 2733
                     C D++EC+  +  + C+Y C N  G + C CP   YR+            C
Sbjct: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 2734 VSGM 2737
            V+G+
Sbjct: 530  VTGI 533



 Score =  194 bits (494), Expect = 8e-49
 Identities = 142/455 (31%), Positives = 203/455 (44%), Gaps = 74/455 (16%)

Query: 1803 TGKAVDIDECKEIPGI---CANG-----VCINQIGSFRCECPTGFSYNDLLLVCEDIDEC 1854
            T K ++++E +E P +   C  G      C +      C C  G+      + CED++EC
Sbjct: 161  TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220

Query: 1855 SNGDNLCQRNADCINSPGSYRCE----CAAGFKLSPNGACVDRNECLE-IPNVCSHGLCV 1909
              G + C+    CIN+ GS+RC+    C  G++L+ + +C D +EC   I N     +C 
Sbjct: 221  ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ 280

Query: 1910 DLQGSYQCI----CHNGFKASQDQT-MCMDVDECER--HPCGNG-TCKNTVGSYNCL--- 1958
            +  GS++C     C +GF   QD    C+D++EC     PC  G TC NT GSY C    
Sbjct: 281  NTLGSFRCRPKLQCKSGF--IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338

Query: 1959 --CYPGFELTHNND-CLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCI 2015
              C  G+ L      C+D+DEC+       +  RC N  GSF+C C  GY      + C+
Sbjct: 339  PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 2016 DTNECVALPGSCSPGTCQNLEGSFRCICPPGY--EVKSENCIDINECDEDPNICLFGSCT 2073
            D NEC   PG      C+N  GS+ C C  G+   V   +C DINEC   P       C 
Sbjct: 399  DVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECA 455

Query: 2074 NTPGGFQCLCPPGFVLSD-NGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMP 2132
            N  G +QC C  G+ LSD +G  C D             +C++P   +    +C    +P
Sbjct: 456  NVYGSYQCYCRRGYQLSDVDGVTCEDI-----------DECALPTGGHICSYRCI--NIP 502

Query: 2133 GEGWGDPCELCPKDDEVAFQDLCP-YGHGTVPSLHDTREDVNECLESPGICS-NGQCINT 2190
            G                +FQ  CP  G+   P+  +  +D++EC+     CS N  C N 
Sbjct: 503  G----------------SFQCSCPSSGYRLAPNGRNC-QDIDECVTGIHNCSINETCFNI 545

Query: 2191 DGSFRC---ECPMGYNLDYT----GVRCVDTDECS 2218
             G FRC   ECP  Y          + C +  ECS
Sbjct: 546  QGGFRCLAFECPENYRRSAATRCERLPCHENRECS 580



 Score =  194 bits (493), Expect = 1e-48
 Identities = 135/401 (33%), Positives = 185/401 (46%), Gaps = 58/401 (14%)

Query: 970  RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAV 1029
            +C ++     C C  G  L   G  C D+           +ECI         ++C   V
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDV-----------NECITGSHSCRLGESCINTV 237

Query: 1030 GAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGK- 1088
            G+     C+     GT                G  LT     KDI+EC++    C     
Sbjct: 238  GSF---RCQRDSSCGT----------------GYELTEDNSCKDIDECESGIHNCLPDFI 278

Query: 1089 CRNTIGSFKCR----CNSGFALDMEERNCTDIDECRISPDLCGSG-ICVNTPGSFECE-- 1141
            C+NT+GSF+CR    C SGF  D    NC DI+EC      C  G  C+NT GS+ C+  
Sbjct: 279  CQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKN 337

Query: 1142 ---CFEGY---ESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEGSFQCDCPLGHELSPS 1194
               C  GY   E G      C+D+DEC      C +G  CVN+ GSF+C+C  G+     
Sbjct: 338  VPNCGRGYHLNEEG----TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI 393

Query: 1195 REDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD 1254
               CVD+NEC          KC N +G+Y CSC+ G++ + D + C DI+EC   +  C 
Sbjct: 394  SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCS 451

Query: 1255 TQCTNSEGSYECSCSEGYALMP-DGRSCADIDEC--ENNPDICDGGQCTNIPGEYRCLC- 1310
             +C N  GSY+C C  GY L   DG +C DIDEC       IC   +C NIPG ++C C 
Sbjct: 452  QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCP 510

Query: 1311 YDGFMASMDMKTCIDVNECDLNSNICMFGE-CENTKGSFIC 1350
              G+  + + + C D++EC    + C   E C N +G F C
Sbjct: 511  SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  189 bits (480), Expect = 3e-47
 Identities = 136/404 (33%), Positives = 181/404 (44%), Gaps = 71/404 (17%)

Query: 493 QTIDICKHHANLCLNGR-CIPTVSSYRCE----CNMGYKQDANGDCIDVDECTS---NPC 544
           + ++ C   ++ C  G  CI TV S+RC+    C  GY+   +  C D+DEC S   N  
Sbjct: 215 EDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCL 274

Query: 545 TNGDCVNTPGSYYCK----CHAGFQRTPTKQACIDIDECIQNGVLCKNGR-CVNTDGSFQ 599
            +  C NT GS+ C+    C +GF +      CIDI+EC+     C  G  C+NT+GS+ 
Sbjct: 275 PDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYT 333

Query: 600 C-----ICNAGFELTTDGKNCVDHDECT-TTNMCLNG-MCINEDGSFKCICKPGFVLAPN 652
           C      C  G+ L  +G  CVD DEC      C  G  C+N  GSF+C CK G+     
Sbjct: 334 CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI 393

Query: 653 GRYCTDVDECQT-PGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIK 711
            R C DV+ECQ  PG      C N+ GS+ C C  G  + +DGR C D            
Sbjct: 394 SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI----------- 442

Query: 712 KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGIT-VDG---R 767
                         +EC           PC    A     +   C  G  ++ VDG    
Sbjct: 443 --------------NECS--------SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480

Query: 768 DINECALDP--DICANGICENLRGSYRCNC-NSGYEPDASGRNCIDIDECLVNRLLCD-N 823
           DI+ECAL     IC+   C N+ GS++C+C +SGY    +GRNC DIDEC+     C  N
Sbjct: 481 DIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539

Query: 824 GLCRNTPGSYSC---TCPPGY----VFRTETETCEDINECESNP 860
             C N  G + C    CP  Y      R E   C +  EC   P
Sbjct: 540 ETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLP 583



 Score =  174 bits (440), Expect = 1e-42
 Identities = 141/454 (31%), Positives = 187/454 (41%), Gaps = 75/454 (16%)

Query: 537 DECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGR-CVNTD 595
           D C         C +T     C C  G+Q      +C D++ECI     C+ G  C+NT 
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237

Query: 596 GSFQC----ICNAGFELTTDGKNCVDHDECTT-TNMCL-NGMCINEDGSFKCI----CKP 645
           GSF+C     C  G+ELT D  +C D DEC +  + CL + +C N  GSF+C     CK 
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 646 GFVLAPNGRYCTDVDECQTPGI-CMNGH-CINSEGSFRC-----DCPPGLAVGMDGRVCV 698
           GF+    G  C D++EC +    C  GH CIN+EGS+ C     +C  G  +  +G  CV
Sbjct: 297 GFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 699 DTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSS 758
           D                           EC       G G  C   P     E    C +
Sbjct: 356 DV-------------------------DECAPPAEPCGKGHRCVNSPGSFRCE----CKT 386

Query: 759 GV---GITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL 815
           G    GI+    D+NEC   P       CEN  GSY C+C+ G+     GR+C DI+EC 
Sbjct: 387 GYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS 446

Query: 816 VNRLLCDNGLCRNTPGSYSCTCPPGY-VFRTETETCEDINEC---ESNPCVNGACRNNLG 871
            +    +   C N  GSY C C  GY +   +  TCEDI+EC         +  C N  G
Sbjct: 447 SSPCSQE---CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPG 503

Query: 872 SFNCEC-SPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGS 930
           SF C C S G +L+  G  C D              C   I+  ++   C    G   G 
Sbjct: 504 SFQCSCPSSGYRLAPNGRNCQDI-----------DECVTGIHNCSINETCFNIQG---GF 549

Query: 931 PCERCELDTACPRGLA-RIKGVTCEDVNECEVFP 963
            C   E      R  A R + + C +  EC   P
Sbjct: 550 RCLAFECPENYRRSAATRCERLPCHENRECSKLP 583



 Score =  168 bits (425), Expect = 8e-41
 Identities = 139/464 (29%), Positives = 194/464 (41%), Gaps = 96/464 (20%)

Query: 1464 QCLNVPGAYRCECEMGFTPASDSRSCQDIDEC-SFQNICVFG-TCNNLPGMFHC----IC 1517
            QC +      C C +G+   SD  SC+D++EC +  + C  G +C N  G F C     C
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248

Query: 1518 DDGYELDRTGGNCTDIDECADPI-NCV-NGLCVNTPGRYECNCPPDFQLNPTGVGCVDNR 1575
              GYEL     +C DIDEC   I NC+ + +C NT G + C   P  Q      G + + 
Sbjct: 249  GTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCR--PKLQCKS---GFIQDA 302

Query: 1576 VGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPG 1635
            +GNC           +  N  + +     S  C +G        TC  +N+   YT    
Sbjct: 303  LGNC-----------IDINECLSI-----SAPCPIG-------HTC--INTEGSYTCQKN 337

Query: 1636 ----GEGFRPNPITIILEDIDECQELPGLC-QGGNCINTFGSFQCECPQGYYLSEDTRIC 1690
                G G+  N       D+DEC      C +G  C+N+ GSF+CEC  GYY    +R+C
Sbjct: 338  VPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC 397

Query: 1691 EDIDECFAHPG-VCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTC 1749
             D++EC  +PG +CG   C NTLG+Y C C   +     G +C D+ +       + + C
Sbjct: 398  VDVNECQRYPGRLCG-HKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC------SSSPC 450

Query: 1750 ENELPFNVTKRMCCCT--YNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAV 1807
              E         C C   Y +       CE                              
Sbjct: 451  SQECANVYGSYQCYCRRGYQLSDVDGVTCE------------------------------ 480

Query: 1808 DIDECKEIPG--ICANGVCINQIGSFRCECP-TGFSYNDLLLVCEDIDECSNGDNLCQRN 1864
            DIDEC    G  IC+   CIN  GSF+C CP +G+        C+DIDEC  G + C  N
Sbjct: 481  DIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539

Query: 1865 ADCINSPGSYRC---ECAAGFKLSPNGACV-----DRNECLEIP 1900
              C N  G +RC   EC   ++ S    C      +  EC ++P
Sbjct: 540  ETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLP 583



 Score =  164 bits (414), Expect = 2e-39
 Identities = 141/506 (27%), Positives = 186/506 (36%), Gaps = 125/506 (24%)

Query: 2109 ENGKCSVPKAFNTTK--------AKCCCSKMPGEGWGDPCEL---------------CPK 2145
            E  +C+ P   N +           CC      +  G  CE                C K
Sbjct: 87   EQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVK 146

Query: 2146 DDEVAFQDLCPYGH-GTVPSLHDTRED--VNECLESPGICSNGQCINTDGSFRCECPMGY 2202
              E    D+        +  + + +ED  +N+     G C   QC +T     C C +GY
Sbjct: 147  SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQ-QCRDTGDEVVCSCFVGY 205

Query: 2203 NLDYTGVRCVDTDECSIG----------------------NPCGNG-------------- 2226
             L   GV C D +EC  G                      + CG G              
Sbjct: 206  QLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDE 265

Query: 2227 ------------TCTNVIGSFEC----NCNEGFEPGPMMNCEDINECAQNPLLC--AFRC 2268
                         C N +GSF C     C  GF    + NC DINEC      C     C
Sbjct: 266  CESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTC 325

Query: 2269 MNTFGSYEC-----TCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCIC 2323
            +NT GSY C      C  GY L E+   C D+DECA     C  +G  C N  G+F C C
Sbjct: 326  INTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC-GKGHRCVNSPGSFRCEC 384

Query: 2324 PPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQ 2383
              G         CVD NEC+  PG     +C N +GSY C C+ GF+ S  G  C D  +
Sbjct: 385  KTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINE 444

Query: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGY 2443
              C +      C       N+    +C C  G       +L  + G       C      
Sbjct: 445  --CSSSPCSQEC------ANVYGSYQCYCRRG------YQLSDVDGVT-----C------ 479

Query: 2444 TTDGRDIDECKVMP--NLCTNGQCINTMGSFRCFC-KVGYTTDISGTSCIDLDECSQSPK 2500
                 DIDEC +    ++C+  +CIN  GSF+C C   GY    +G +C D+DEC     
Sbjct: 480  ----EDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIH 534

Query: 2501 PC--NYICKNTEGSYQC---SCPRGY 2521
             C  N  C N +G ++C    CP  Y
Sbjct: 535  NCSINETCFNIQGGFRCLAFECPENY 560



 Score =  149 bits (376), Expect = 4e-35
 Identities = 175/634 (27%), Positives = 242/634 (38%), Gaps = 134/634 (21%)

Query: 592  VNTDGSFQCICNAGFELTTDGKNC-----VDHDECTTTNMCLNGMCINEDGSFKCICKPG 646
            V+ D   +  C  G  + T  K+C      +  EC    M     C ++     C    G
Sbjct: 27   VDADVLLEACCADGHRMATHQKDCSLPYATESKEC---RMVQEQCCHSQLEELHCAT--G 81

Query: 647  FVLAPNGRYCTDVDECQTPGICMNGHCINSEGSF--RCD--CPPGLAVGMDGRVCVDTHM 702
              LA       + D C TP    +G   + E +F  RC   C  G A    G+ C  + M
Sbjct: 82   ISLA------NEQDRCATP----HGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLM 131

Query: 703  RSTCYGGIKKGVCVRPFP------GAVTKSECCCA----------NPDYGFGEPCQPCPA 746
                 G + +  CV+         G + +++              N     G PC+    
Sbjct: 132  VGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCR 191

Query: 747  KNSAEFHGLCSSGVGITVDG---RDINECALDPDICANG-ICENLRGSYRC----NCNSG 798
                E    C  G  +  DG    D+NEC      C  G  C N  GS+RC    +C +G
Sbjct: 192  DTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTG 251

Query: 799  YEPDASGRNCIDIDECLVNRLLC-DNGLCRNTPGSYSCT----CPPGYVFRTETETCEDI 853
            YE      +C DIDEC      C  + +C+NT GS+ C     C  G++ +     C DI
Sbjct: 252  YEL-TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI-QDALGNCIDI 309

Query: 854  NECES--NPCVNG-ACRNNLGSFNCE-----CSPGSKLSSTGLICIDSLKGTCWLNIQDS 905
            NEC S   PC  G  C N  GS+ C+     C  G  L+  G  C+D             
Sbjct: 310  NECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVD------------- 356

Query: 906  RCEVNINGATLKSECCATLGAAWGSPCE-RCELDTACP-RGLARIKGVTCEDVNECEVFP 963
                 ++     +E C        SP   RCE  T     G++R+    C DVNEC+ +P
Sbjct: 357  -----VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRM----CVDVNECQRYP 407

Query: 964  GVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMD 1023
            G     +C N+ GS+ C C  G  L   GR C DI   +C       EC +         
Sbjct: 408  GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI--NECSSSPCSQECAN--------- 456

Query: 1024 ACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPG- 1082
                     +G+            Y+  C RG   ++   V       +DI+EC    G 
Sbjct: 457  --------VYGS------------YQCYCRRGYQLSDVDGVTC-----EDIDECALPTGG 491

Query: 1083 -MCTYGKCRNTIGSFKCRC-NSGFALDMEERNCTDIDECRISPDLCG-SGICVNTPGSFE 1139
             +C+Y +C N  GSF+C C +SG+ L    RNC DIDEC      C  +  C N  G F 
Sbjct: 492  HICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFR 550

Query: 1140 C---ECFEGYESGFMMMKN---CMDIDECERNPL 1167
            C   EC E Y            C +  EC + PL
Sbjct: 551  CLAFECPENYRRSAATRCERLPCHENRECSKLPL 584



 Score =  144 bits (363), Expect = 1e-33
 Identities = 118/398 (29%), Positives = 172/398 (43%), Gaps = 86/398 (21%)

Query: 273 ACQDVDECQAIPGICQ-GGNCINTVGSFECR----CPAGHKQSETTQKCEDIDEC-SIIP 326
           +C+DV+EC      C+ G +CINTVGSF C+    C  G++ +E    C+DIDEC S I 
Sbjct: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIH 271

Query: 327 GICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKM 386
                  C NT+GS+               RC  +    C SG +     Q+  G     
Sbjct: 272 NCLPDFICQNTLGSF---------------RCRPKL--QCKSGFI-----QDALGN---- 305

Query: 387 QCCCEPGRCWGIGTIPEACPVRGS---EEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFA 443
             C +   C  I      CP+  +    E    C   +P                     
Sbjct: 306 --CIDINECLSISA---PCPIGHTCINTEGSYTCQKNVPN-------------------- 340

Query: 444 PSGNGNGYGPGGTGFIPI--------PGGNGF----SPGVGGAGVGAGGQGPIITGLTIL 491
             G G      GT  + +        P G G     SPG        G       G++ +
Sbjct: 341 -CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY---FDGISRM 396

Query: 492 NQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANG-DCIDVDECTSNPCTNGDCV 550
              ++ C+ +       +C  T+ SY C C++G++   +G  C D++EC+S+PC+  +C 
Sbjct: 397 CVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ-ECA 455

Query: 551 NTPGSYYCKCHAGFQRTPTK-QACIDIDECI--QNGVLCKNGRCVNTDGSFQCIC-NAGF 606
           N  GSY C C  G+Q +      C DIDEC     G +C + RC+N  GSFQC C ++G+
Sbjct: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCPSSGY 514

Query: 607 ELTTDGKNCVDHDECTT--TNMCLNGMCINEDGSFKCI 642
            L  +G+NC D DEC T   N  +N  C N  G F+C+
Sbjct: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552



 Score = 99.0 bits (245), Expect = 6e-20
 Identities = 99/327 (30%), Positives = 134/327 (40%), Gaps = 51/327 (15%)

Query: 97  CCPGWKTLPGG------NQCIV--------PICRNSCGDGFCSRPNMCTCSSGQISSTCG 142
           C  G++ L  G      N+CI           C N+ G   C R + C  +  +++    
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG-TGYELTEDNS 259

Query: 143 SKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNG------GRCIGPNRC 196
            K I +C     N   C  D   CQ   +G++  +P  +  C++G      G CI  N C
Sbjct: 260 CKDIDECESGIHN---CLPDFI-CQNT-LGSFRCRPKLQ--CKSGFIQDALGNCIDINEC 312

Query: 197 A-----CVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLT--GIVCTKTLCCATIGRAWG- 248
                 C  G T    E  Y    C   V N      L   G  C     CA      G 
Sbjct: 313 LSISAPCPIGHTCINTEGSYT---CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGK 369

Query: 249 -HPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAG 306
            H C   P   +  C+ G+  +  +  C DV+ECQ  PG   G  C NT+GS+ C C  G
Sbjct: 370 GHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVG 429

Query: 307 HKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGY-VTSTDGSRC--IDQRT 363
            + S   + CEDI+ECS  P  C   EC+N  GSY C C RGY ++  DG  C  ID+  
Sbjct: 430 FRLSVDGRSCEDINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486

Query: 364 GMCFSGLVNGRCAQELPGRMTKMQCCC 390
                 + + RC   +PG     QC C
Sbjct: 487 LPTGGHICSYRCI-NIPG---SFQCSC 509



 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 81/299 (27%), Positives = 113/299 (37%), Gaps = 66/299 (22%)

Query: 152 RCMNGGTCADDHCQCQKGYIGTYC----GQPVCENG--CQNGGRCI-GPNRC----ACVY 200
           RC  GG C     QC+       C    G  +  +G  C++   CI G + C    +C+ 
Sbjct: 179 RCRGGGPCKQ---QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235

Query: 201 GFTGPQCERDYRTGP---------------CFTQVNNQM----CQGQLTGIVCTKTLCCA 241
                +C+RD   G                C + ++N +    CQ  L    C   L C 
Sbjct: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 242 T--IGRAWGH------------PCEM------------CPAQPQPCRRGFIPNIRTGACQ 275
           +  I  A G+            PC +            C      C RG+  N     C 
Sbjct: 296 SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 276 DVDECQAIPGIC-QGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGEC 334
           DVDEC      C +G  C+N+ GSF C C  G+     ++ C D++EC   PG     +C
Sbjct: 356 DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415

Query: 335 SNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
            NT+GSY C C  G+  S DG  C D       +   +  C+QE        QC C  G
Sbjct: 416 ENTLGSYLCSCSVGFRLSVDGRSCED------INECSSSPCSQECANVYGSYQCYCRRG 468



 Score = 89.0 bits (219), Expect = 6e-17
 Identities = 98/306 (32%), Positives = 129/306 (42%), Gaps = 76/306 (24%)

Query: 114 ICRNSCGDGFCSRPNMCTCSSGQISSTCGSK-SIQQC---SVRCMNGGTCADDH----CQ 165
           IC+N+ G   C RP +  C SG I    G+   I +C   S  C  G TC +      CQ
Sbjct: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335

Query: 166 -----CQKGYI----GTYCGQ-----PVCENGCQNGGRCI---GPNRCACVYGFTGPQCE 208
                C +GY     GT C       P  E  C  G RC+   G  RC C  G+      
Sbjct: 336 KNVPNCGRGYHLNEEGTRCVDVDECAPPAEP-CGKGHRCVNSPGSFRCECKTGY------ 388

Query: 209 RDYRTGPCFTQVNNQMCQ---GQLTGIVCTKTL----CCATIG---RAWGHPCE---MCP 255
             Y  G     V+   CQ   G+L G  C  TL    C  ++G      G  CE    C 
Sbjct: 389 --YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS 446

Query: 256 AQPQP-------------CRRGF-IPNIRTGACQDVDECQAIPG--ICQGGNCINTVGSF 299
           + P               CRRG+ + ++    C+D+DEC    G  IC    CIN  GSF
Sbjct: 447 SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSF 505

Query: 300 ECRCP-AGHKQSETTQKCEDIDECSIIPGI--CETGE-CSNTVGSYFCV---CPRGYVTS 352
           +C CP +G++ +   + C+DIDEC  + GI  C   E C N  G + C+   CP  Y  S
Sbjct: 506 QCSCPSSGYRLAPNGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCLAFECPENYRRS 563

Query: 353 TDGSRC 358
              +RC
Sbjct: 564 A-ATRC 568



 Score = 68.9 bits (167), Expect = 7e-11
 Identities = 87/372 (23%), Positives = 142/372 (38%), Gaps = 83/372 (22%)

Query: 2410 CCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTM 2469
            CC DG R   HQ + C LP              Y T+ +   EC+++   C    C + +
Sbjct: 36   CCADGHRMATHQKD-CSLP--------------YATESK---ECRMVQEQC----CHSQL 73

Query: 2470 GSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPR-GYVLQEDGK 2528
                C       T IS  +  + D C+ +P   N   + T     C C   G   Q  G+
Sbjct: 74   EELHC------ATGISLAN--EQDRCA-TPHGDNASLEATFVKRCCHCCLLGRAAQAQGQ 124

Query: 2529 TCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGIC 2588
            +C+                 + + G+ C            C+ + E G         G  
Sbjct: 125  SCE----------------YSLMVGYQCG-----QVFRACCVKSQETGDLDV-----GGL 158

Query: 2589 QNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQ 2648
            Q T      E ++    +   LN    D C G   C+  C++      C C  GY     
Sbjct: 159  QETDKIIEVEEEQ----EDPYLN----DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSD 210

Query: 2649 WNQCVDENEC-SNPNACG-SASCYNTLGSYKC----ACPSGFSFDQFSSACHDVNECSSS 2702
               C D NEC +  ++C    SC NT+GS++C    +C +G+   +  ++C D++EC S 
Sbjct: 211  GVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESG 269

Query: 2703 KNPC--NYGCSNTEGGYLC----GCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENA 2756
             + C  ++ C NT G + C     C  G+ +   G+C+     N+   +S    +     
Sbjct: 270  IHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCID---INECLSISAPCPIG-HTC 325

Query: 2757 LSPEACYECKIN 2768
            ++ E  Y C+ N
Sbjct: 326  INTEGSYTCQKN 337


>gi|34734066 fibulin 1 isoform D [Homo sapiens]
          Length = 703

 Score =  234 bits (596), Expect = 1e-60
 Identities = 142/427 (33%), Positives = 210/427 (49%), Gaps = 48/427 (11%)

Query: 1131 CVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCR-GGTCVNTEGSFQCD----C 1185
            C +T     C CF GY+       +C D++EC      CR G +C+NT GSF+C     C
Sbjct: 190  CRDTGDEVVCSCFVGYQL-LSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248

Query: 1186 PLGHELSPSREDCVDINECSLSDNLCR-NGKCVNMIGTYQC----SCNPGYQATPDRQG- 1239
              G+EL+     C DI+EC    + C  +  C N +G+++C     C  G+    D  G 
Sbjct: 249  GTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF--IQDALGN 305

Query: 1240 CTDIDECMIMNGGCDT--QCTNSEGSYEC-----SCSEGYALMPDGRSCADIDECENNPD 1292
            C DI+EC+ ++  C     C N+EGSY C     +C  GY L  +G  C D+DEC    +
Sbjct: 306  CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAE 365

Query: 1293 ICDGG-QCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICH 1351
             C  G +C N PG +RC C  G+      + C+DVNEC          +CENT GS++C 
Sbjct: 366  PCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCS 425

Query: 1352 CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW---IGNGIKCID 1408
            C +G+ +      C D++EC     +      C N+ GS++C CR G+     +G+ C D
Sbjct: 426  CSVGFRLSVDGRSCEDINECS----SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481

Query: 1409 LDECS--NGTHQCSINAQCVNTPGSYRCAC-SEGF--TGDGFTCSDVDECAENINLCE-N 1462
            +DEC+   G H CS   +C+N PGS++C+C S G+    +G  C D+DEC   I+ C  N
Sbjct: 482  IDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539

Query: 1463 GQCLNVPGAYRC---ECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDD 1519
              C N+ G +RC   EC     P +  RS   + +     +    +C   P    C+ D 
Sbjct: 540  ETCFNIQGGFRCLAFEC-----PENYRRSAATLQQEKTDTVRCIKSCR--PNDVTCVFDP 592

Query: 1520 GYELDRT 1526
             + +  T
Sbjct: 593  VHTISHT 599



 Score =  225 bits (574), Expect = 4e-58
 Identities = 149/446 (33%), Positives = 200/446 (44%), Gaps = 72/446 (16%)

Query: 2215 DECSIGNPCGNGTCTNVIGSFECNCNEGFEP-GPMMNCEDINECAQNPLLCAF--RCMNT 2271
            D C  G PC    C +      C+C  G++     ++CED+NEC      C     C+NT
Sbjct: 178  DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 2272 FGSYEC----TCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI----C 2323
             GS+ C    +C  GY L ED   CKD+DEC  G+H+C     +C+N +G+F C     C
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLP-DFICQNTLGSFRCRPKLQC 294

Query: 2324 PPGMARRPDGEGCVDENECRTKPGICENGR-CVNIIGSYRCE-----CNEGFQSSSSGTE 2377
              G  +   G  C+D NEC +    C  G  C+N  GSY C+     C  G+  +  GT 
Sbjct: 295  KSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353

Query: 2378 CLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKIC 2437
            C+D  +                        +E C     G GH+C     PG+ +    C
Sbjct: 354  CVDVDE--------------------CAPPAEPC-----GKGHRC--VNSPGSFR----C 382

Query: 2438 PHGPGYTTDGR-----DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDL 2492
                GY  DG      D++EC+  P      +C NT+GS+ C C VG+   + G SC D+
Sbjct: 383  ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI 442

Query: 2493 DECSQSPKPCNYICKNTEGSYQCSCPRGYVLQE-DGKTCKDLDEC--QTKQHNCQFLCVN 2549
            +ECS S  PC+  C N  GSYQC C RGY L + DG TC+D+DEC   T  H C + C+N
Sbjct: 443  NECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCIN 500

Query: 2550 TLGGFTCKCPPG---FTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSC---ECQRGF 2603
              G F C CP        +   C D +EC +    C     C N  G F C   EC   +
Sbjct: 501  IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560

Query: 2604 SLDATGLNCEDVDECDGNHRCQHGCQ 2629
               A  L  E  D      RC   C+
Sbjct: 561  RRSAATLQQEKTDTV----RCIKSCR 582



 Score =  211 bits (536), Expect = 1e-53
 Identities = 145/414 (35%), Positives = 202/414 (48%), Gaps = 62/414 (14%)

Query: 1942 PCGNGTCKNTVGSYNCLCYPGFELTHNN-DCLDIDECSSFFGQVCRNGR-CFNEIGSFKC 1999
            PC    C++T     C C+ G++L  +   C D++EC +     CR G  C N +GSF+C
Sbjct: 185  PCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITG-SHSCRLGESCINTVGSFRC 242

Query: 2000 L----CNEGYELTPDGKNCIDTNECVALPGSCSPG-TCQNLEGSFRCI----CPPGY-EV 2049
                 C  GYELT D  +C D +EC +   +C P   CQN  GSFRC     C  G+ + 
Sbjct: 243  QRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD 301

Query: 2050 KSENCIDINECDEDPNICLFG-SCTNTPGGFQCL-----CPPGFVLSDNGRRCFDTRQSF 2103
               NCIDINEC      C  G +C NT G + C      C  G+ L++ G RC D  +  
Sbjct: 302  ALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE-- 359

Query: 2104 CFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVP 2163
                     C+ P       A+ C       G G  C   P     +F+  C  G+    
Sbjct: 360  ---------CAPP-------AEPC-------GKGHRCVNSPG----SFRCECKTGY-YFD 391

Query: 2164 SLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPC 2223
             +     DVNEC   PG     +C NT GS+ C C +G+ L   G  C D +ECS  +PC
Sbjct: 392  GISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPC 450

Query: 2224 GNGTCTNVIGSFECNCNEGFEPGPM--MNCEDINECA--QNPLLCAFRCMNTFGSYECTC 2279
                C NV GS++C C  G++   +  + CEDI+ECA      +C++RC+N  GS++C+C
Sbjct: 451  SQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSC 509

Query: 2280 P-IGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI---CPPGMAR 2329
            P  GY L  + + C+D+DEC  G+H+C S    C N+ G F C+   CP    R
Sbjct: 510  PSSGYRLAPNGRNCQDIDECVTGIHNC-SINETCFNIQGGFRCLAFECPENYRR 562



 Score =  207 bits (528), Expect = 9e-53
 Identities = 177/614 (28%), Positives = 242/614 (39%), Gaps = 122/614 (19%)

Query: 1166 PLLCRGGTC-----VNTEGSFQCDCPLGHELSPSREDC-----VDINECSLSDNLCRNGK 1215
            PLL  GG       V+ +   +  C  GH ++  ++DC      +  EC +    C    
Sbjct: 13   PLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQC---- 68

Query: 1216 CVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNG-GCDTQCTNSEGSYECSCSEGYAL 1274
            C + +    C+         DR        C   +G     + T  +    C C  G A 
Sbjct: 69   CHSQLEELHCATGISLANEQDR--------CATPHGDNASLEATFVKRCCHC-CLLGRAA 119

Query: 1275 MPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYD---------GFMASMDMKTCID 1325
               G+SC           +  G QC  +   +R  C           G +   D    ++
Sbjct: 120  QAQGQSC--------EYSLMVGYQCGQV---FRACCVKSQETGDLDVGGLQETDKIIEVE 168

Query: 1326 VNECD--LNSNICMFG-----ECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNC 1378
              + D  LN   C  G     +C +T    +C C +GY +      C DV+EC  G+H+C
Sbjct: 169  EEQEDPYLNDR-CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227

Query: 1379 DMHASCLNIPGSFKC----SCREGW-IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYR 1433
             +  SC+N  GSF+C    SC  G+ +     C D+DEC +G H C  +  C NT GS+R
Sbjct: 228  RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFR 287

Query: 1434 C----ACSEGFTGDGF-TCSDVDECAENINLCENGQ-CLNVPGAYRCE-----CEMGFTP 1482
            C     C  GF  D    C D++EC      C  G  C+N  G+Y C+     C  G+  
Sbjct: 288  CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL 347

Query: 1483 ASDSRSCQDIDECS-FQNICVFG-TCNNLPGMFHCICDDGYELDRTGGNCTDIDECAD-P 1539
              +   C D+DEC+     C  G  C N PG F C C  GY  D     C D++EC   P
Sbjct: 348  NEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYP 407

Query: 1540 INCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGV 1599
                   C NT G Y C+C   F+L+  G  C D  +  C          S  C+ E   
Sbjct: 408  GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED--INEC---------SSSPCSQECAN 456

Query: 1600 GVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPG 1659
                  C C  G                  Y L         +   +  EDIDEC     
Sbjct: 457  VYGSYQCYCRRG------------------YQL--------SDVDGVTCEDIDEC----A 486

Query: 1660 LCQGGN-----CINTFGSFQCECP-QGYYLSEDTRICEDIDECFAHPGVCGPG-TCYNTL 1712
            L  GG+     CIN  GSFQC CP  GY L+ + R C+DIDEC      C    TC+N  
Sbjct: 487  LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQ 546

Query: 1713 GNYTCI---CPPEY 1723
            G + C+   CP  Y
Sbjct: 547  GGFRCLAFECPENY 560



 Score =  204 bits (518), Expect = 1e-51
 Identities = 120/284 (42%), Positives = 143/284 (50%), Gaps = 25/284 (8%)

Query: 2464 QCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNY--ICKNTEGSYQC----SC 2517
            QC +T     C C VGY     G SC D++EC      C     C NT GS++C    SC
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248

Query: 2518 PRGYVLQEDGKTCKDLDECQTKQHNC--QFLCVNTLGGFTCK----CPPGFTQHHTA-CI 2570
              GY L ED  +CKD+DEC++  HNC   F+C NTLG F C+    C  GF Q     CI
Sbjct: 249  GTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCI 307

Query: 2571 DNNECGSQPSLCGAKGICQNTPGSFSCE-----CQRGFSLDATGLNCEDVDEC-DGNHRC 2624
            D NEC S  + C     C NT GS++C+     C RG+ L+  G  C DVDEC      C
Sbjct: 308  DINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367

Query: 2625 Q--HGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSN-PNACGSASCYNTLGSYKCACP 2681
               H C N  G +RC C  GY        CVD NEC   P       C NTLGSY C+C 
Sbjct: 368  GKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCS 427

Query: 2682 SGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGY 2725
             GF       +C D+NECSSS  PC+  C+N  G Y C C  GY
Sbjct: 428  VGFRLSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGY 469



 Score =  196 bits (497), Expect = 4e-49
 Identities = 123/364 (33%), Positives = 169/364 (46%), Gaps = 48/364 (13%)

Query: 2412 CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYT--TDG---RDIDECKVMPNLCTNGQ-C 2465
            C GG     QC           + +C    GY   +DG    D++EC    + C  G+ C
Sbjct: 180  CRGGGPCKQQCR------DTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESC 233

Query: 2466 INTMGSFRC----FCKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQC---- 2515
            INT+GSFRC     C  GY       SC D+DEC      C  ++IC+NT GS++C    
Sbjct: 234  INTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292

Query: 2516 SCPRGYVLQEDGKTCKDLDECQTKQHNCQF--LCVNTLGGFTCK-----CPPGF--TQHH 2566
             C  G++    G  C D++EC +    C     C+NT G +TC+     C  G+   +  
Sbjct: 293  QCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351

Query: 2567 TACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDG--NHRC 2624
            T C+D +EC      CG    C N+PGSF CEC+ G+  D     C DV+EC       C
Sbjct: 352  TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411

Query: 2625 QHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGF 2684
             H C+N LG Y C C  G+        C D NECS+ + C S  C N  GSY+C C  G+
Sbjct: 412  GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-SPC-SQECANVYGSYQCYCRRGY 469

Query: 2685 SFDQFSSA-CHDVNECS--SSKNPCNYGCSNTEGGYLCGCPPGYYRVGQG--------HC 2733
                     C D++EC+  +  + C+Y C N  G + C CP   YR+            C
Sbjct: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 2734 VSGM 2737
            V+G+
Sbjct: 530  VTGI 533



 Score =  194 bits (493), Expect = 1e-48
 Identities = 140/448 (31%), Positives = 201/448 (44%), Gaps = 70/448 (15%)

Query: 1803 TGKAVDIDECKEIPGI---CANG-----VCINQIGSFRCECPTGFSYNDLLLVCEDIDEC 1854
            T K ++++E +E P +   C  G      C +      C C  G+      + CED++EC
Sbjct: 161  TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220

Query: 1855 SNGDNLCQRNADCINSPGSYRCE----CAAGFKLSPNGACVDRNECLE-IPNVCSHGLCV 1909
              G + C+    CIN+ GS+RC+    C  G++L+ + +C D +EC   I N     +C 
Sbjct: 221  ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ 280

Query: 1910 DLQGSYQCI----CHNGFKASQDQT-MCMDVDECER--HPCGNG-TCKNTVGSYNCL--- 1958
            +  GS++C     C +GF   QD    C+D++EC     PC  G TC NT GSY C    
Sbjct: 281  NTLGSFRCRPKLQCKSGF--IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338

Query: 1959 --CYPGFELTHNND-CLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCI 2015
              C  G+ L      C+D+DEC+       +  RC N  GSF+C C  GY      + C+
Sbjct: 339  PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 2016 DTNECVALPGSCSPGTCQNLEGSFRCICPPGY--EVKSENCIDINECDEDPNICLFGSCT 2073
            D NEC   PG      C+N  GS+ C C  G+   V   +C DINEC   P       C 
Sbjct: 399  DVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECA 455

Query: 2074 NTPGGFQCLCPPGFVLSD-NGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMP 2132
            N  G +QC C  G+ LSD +G  C D             +C++P   +    +C    +P
Sbjct: 456  NVYGSYQCYCRRGYQLSDVDGVTCEDI-----------DECALPTGGHICSYRCI--NIP 502

Query: 2133 GEGWGDPCELCPKDDEVAFQDLCP-YGHGTVPSLHDTREDVNECLESPGICS-NGQCINT 2190
            G                +FQ  CP  G+   P+  +  +D++EC+     CS N  C N 
Sbjct: 503  G----------------SFQCSCPSSGYRLAPNGRNC-QDIDECVTGIHNCSINETCFNI 545

Query: 2191 DGSFRC---ECPMGYNLDYTGVRCVDTD 2215
             G FRC   ECP  Y      ++   TD
Sbjct: 546  QGGFRCLAFECPENYRRSAATLQQEKTD 573



 Score =  194 bits (493), Expect = 1e-48
 Identities = 135/401 (33%), Positives = 185/401 (46%), Gaps = 58/401 (14%)

Query: 970  RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAV 1029
            +C ++     C C  G  L   G  C D+           +ECI         ++C   V
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDV-----------NECITGSHSCRLGESCINTV 237

Query: 1030 GAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGK- 1088
            G+     C+     GT                G  LT     KDI+EC++    C     
Sbjct: 238  GSF---RCQRDSSCGT----------------GYELTEDNSCKDIDECESGIHNCLPDFI 278

Query: 1089 CRNTIGSFKCR----CNSGFALDMEERNCTDIDECRISPDLCGSG-ICVNTPGSFECE-- 1141
            C+NT+GSF+CR    C SGF  D    NC DI+EC      C  G  C+NT GS+ C+  
Sbjct: 279  CQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKN 337

Query: 1142 ---CFEGY---ESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEGSFQCDCPLGHELSPS 1194
               C  GY   E G      C+D+DEC      C +G  CVN+ GSF+C+C  G+     
Sbjct: 338  VPNCGRGYHLNEEG----TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI 393

Query: 1195 REDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD 1254
               CVD+NEC          KC N +G+Y CSC+ G++ + D + C DI+EC   +  C 
Sbjct: 394  SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCS 451

Query: 1255 TQCTNSEGSYECSCSEGYALMP-DGRSCADIDEC--ENNPDICDGGQCTNIPGEYRCLC- 1310
             +C N  GSY+C C  GY L   DG +C DIDEC       IC   +C NIPG ++C C 
Sbjct: 452  QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCP 510

Query: 1311 YDGFMASMDMKTCIDVNECDLNSNICMFGE-CENTKGSFIC 1350
              G+  + + + C D++EC    + C   E C N +G F C
Sbjct: 511  SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  192 bits (489), Expect = 3e-48
 Identities = 137/457 (29%), Positives = 196/457 (42%), Gaps = 69/457 (15%)

Query: 2287 EDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKP 2346
            E+++    L++   G   C+ +   C++     +C C  G     DG  C D NEC T  
Sbjct: 168  EEEQEDPYLNDRCRGGGPCKQQ---CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGS 224

Query: 2347 GICENGR-CVNIIGSYRCE----CNEGFQ-SSSSGTECLDNRQGLCFAEVLQTICQMASS 2400
              C  G  C+N +GS+RC+    C  G++ +  +  + +D  +      +   ICQ    
Sbjct: 225  HSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLG 284

Query: 2401 SRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR----DIDECKVM 2456
            S     K +C                               G+  D      DI+EC  +
Sbjct: 285  SFRCRPKLQC-----------------------------KSGFIQDALGNCIDINECLSI 315

Query: 2457 PNLCTNGQ-CINTMGSFRCF-----CKVGYTTDISGTSCIDLDECSQSPKPCN--YICKN 2508
               C  G  CINT GS+ C      C  GY  +  GT C+D+DEC+   +PC   + C N
Sbjct: 316  SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375

Query: 2509 TEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHN-CQFLCVNTLGGFTCKCPPGF--TQH 2565
            + GS++C C  GY      + C D++ECQ      C   C NTLG + C C  GF  +  
Sbjct: 376  SPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVD 435

Query: 2566 HTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSL-DATGLNCEDVDEC---DGN 2621
              +C D NEC S P  C  +  C N  GS+ C C+RG+ L D  G+ CED+DEC    G 
Sbjct: 436  GRSCEDINECSSSP--CSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 491

Query: 2622 HRCQHGCQNILGGYRCGCP-QGYIQHYQWNQCVDENECSN--PNACGSASCYNTLGSYKC 2678
            H C + C NI G ++C CP  GY        C D +EC     N   + +C+N  G ++C
Sbjct: 492  HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551

Query: 2679 ---ACPSGF--SFDQFSSACHDVNECSSSKNPCNYGC 2710
                CP  +  S         D   C  S  P +  C
Sbjct: 552  LAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTC 588



 Score =  187 bits (475), Expect = 1e-46
 Identities = 135/405 (33%), Positives = 183/405 (45%), Gaps = 73/405 (18%)

Query: 493 QTIDICKHHANLCLNGR-CIPTVSSYRCE----CNMGYKQDANGDCIDVDECTS---NPC 544
           + ++ C   ++ C  G  CI TV S+RC+    C  GY+   +  C D+DEC S   N  
Sbjct: 215 EDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCL 274

Query: 545 TNGDCVNTPGSYYCK----CHAGFQRTPTKQACIDIDECIQNGVLCKNGR-CVNTDGSFQ 599
            +  C NT GS+ C+    C +GF +      CIDI+EC+     C  G  C+NT+GS+ 
Sbjct: 275 PDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYT 333

Query: 600 C-----ICNAGFELTTDGKNCVDHDECT-TTNMCLNG-MCINEDGSFKCICKPGFVLAPN 652
           C      C  G+ L  +G  CVD DEC      C  G  C+N  GSF+C CK G+     
Sbjct: 334 CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI 393

Query: 653 GRYCTDVDECQT-PGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIK 711
            R C DV+ECQ  PG      C N+ GS+ C C  G  + +DGR C D            
Sbjct: 394 SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI----------- 442

Query: 712 KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGIT-VDG---R 767
                         +EC           PC    A     +   C  G  ++ VDG    
Sbjct: 443 --------------NECS--------SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480

Query: 768 DINECALDP--DICANGICENLRGSYRCNC-NSGYEPDASGRNCIDIDECLVNRLLCD-N 823
           DI+ECAL     IC+   C N+ GS++C+C +SGY    +GRNC DIDEC+     C  N
Sbjct: 481 DIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539

Query: 824 GLCRNTPGSYSC---TCPPGY------VFRTETETCEDINECESN 859
             C N  G + C    CP  Y      + + +T+T   I  C  N
Sbjct: 540 ETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPN 584



 Score =  170 bits (430), Expect = 2e-41
 Identities = 135/409 (33%), Positives = 177/409 (43%), Gaps = 73/409 (17%)

Query: 537 DECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGR-CVNTD 595
           D C         C +T     C C  G+Q      +C D++ECI     C+ G  C+NT 
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237

Query: 596 GSFQC----ICNAGFELTTDGKNCVDHDECTT-TNMCL-NGMCINEDGSFKCI----CKP 645
           GSF+C     C  G+ELT D  +C D DEC +  + CL + +C N  GSF+C     CK 
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 646 GFVLAPNGRYCTDVDECQTPGI-CMNGH-CINSEGSFRC-----DCPPGLAVGMDGRVCV 698
           GF+    G  C D++EC +    C  GH CIN+EGS+ C     +C  G  +  +G  CV
Sbjct: 297 GFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 699 DTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSS 758
           D                           EC       G G  C   P     E    C +
Sbjct: 356 DV-------------------------DECAPPAEPCGKGHRCVNSPGSFRCE----CKT 386

Query: 759 GV---GITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL 815
           G    GI+    D+NEC   P       CEN  GSY C+C+ G+     GR+C DI+EC 
Sbjct: 387 GYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS 446

Query: 816 VNRLLCDNGLCRNTPGSYSCTCPPGY-VFRTETETCEDINEC---ESNPCVNGACRNNLG 871
            +    +   C N  GSY C C  GY +   +  TCEDI+EC         +  C N  G
Sbjct: 447 SSPCSQE---CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPG 503

Query: 872 SFNCEC-SPGSKLSSTGLICID-----------SLKGTCWLNIQDS-RC 907
           SF C C S G +L+  G  C D           S+  TC+ NIQ   RC
Sbjct: 504 SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCF-NIQGGFRC 551



 Score =  164 bits (416), Expect = 9e-40
 Identities = 135/444 (30%), Positives = 187/444 (42%), Gaps = 91/444 (20%)

Query: 1464 QCLNVPGAYRCECEMGFTPASDSRSCQDIDEC-SFQNICVFG-TCNNLPGMFHC----IC 1517
            QC +      C C +G+   SD  SC+D++EC +  + C  G +C N  G F C     C
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248

Query: 1518 DDGYELDRTGGNCTDIDECADPI-NCV-NGLCVNTPGRYECNCPPDFQLNPTGVGCVDNR 1575
              GYEL     +C DIDEC   I NC+ + +C NT G + C   P  Q      G + + 
Sbjct: 249  GTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCR--PKLQCKS---GFIQDA 302

Query: 1576 VGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPG 1635
            +GNC           +  N  + +     S  C +G        TC  +N+   YT    
Sbjct: 303  LGNC-----------IDINECLSI-----SAPCPIG-------HTC--INTEGSYTCQKN 337

Query: 1636 ----GEGFRPNPITIILEDIDECQELPGLC-QGGNCINTFGSFQCECPQGYYLSEDTRIC 1690
                G G+  N       D+DEC      C +G  C+N+ GSF+CEC  GYY    +R+C
Sbjct: 338  VPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC 397

Query: 1691 EDIDECFAHPG-VCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTC 1749
             D++EC  +PG +CG   C NTLG+Y C C   +     G +C D+ +       + + C
Sbjct: 398  VDVNECQRYPGRLCG-HKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC------SSSPC 450

Query: 1750 ENELPFNVTKRMCCCT--YNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAV 1807
              E         C C   Y +       CE                              
Sbjct: 451  SQECANVYGSYQCYCRRGYQLSDVDGVTCE------------------------------ 480

Query: 1808 DIDECKEIPG--ICANGVCINQIGSFRCECP-TGFSYNDLLLVCEDIDECSNGDNLCQRN 1864
            DIDEC    G  IC+   CIN  GSF+C CP +G+        C+DIDEC  G + C  N
Sbjct: 481  DIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539

Query: 1865 ADCINSPGSYRC---ECAAGFKLS 1885
              C N  G +RC   EC   ++ S
Sbjct: 540  ETCFNIQGGFRCLAFECPENYRRS 563



 Score =  148 bits (374), Expect = 7e-35
 Identities = 176/638 (27%), Positives = 244/638 (38%), Gaps = 136/638 (21%)

Query: 592  VNTDGSFQCICNAGFELTTDGKNC-----VDHDECTTTNMCLNGMCINEDGSFKCICKPG 646
            V+ D   +  C  G  + T  K+C      +  EC    M     C ++     C    G
Sbjct: 27   VDADVLLEACCADGHRMATHQKDCSLPYATESKEC---RMVQEQCCHSQLEELHCAT--G 81

Query: 647  FVLAPNGRYCTDVDECQTPGICMNGHCINSEGSF--RCD--CPPGLAVGMDGRVCVDTHM 702
              LA       + D C TP    +G   + E +F  RC   C  G A    G+ C  + M
Sbjct: 82   ISLA------NEQDRCATP----HGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLM 131

Query: 703  RSTCYGGIKKGVCVRPFP------GAVTKSECCCA----------NPDYGFGEPCQPCPA 746
                 G + +  CV+         G + +++              N     G PC+    
Sbjct: 132  VGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCR 191

Query: 747  KNSAEFHGLCSSGVGITVDG---RDINECALDPDICANG-ICENLRGSYRC----NCNSG 798
                E    C  G  +  DG    D+NEC      C  G  C N  GS+RC    +C +G
Sbjct: 192  DTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTG 251

Query: 799  YEPDASGRNCIDIDECLVNRLLC-DNGLCRNTPGSYSCT----CPPGYVFRTETETCEDI 853
            YE      +C DIDEC      C  + +C+NT GS+ C     C  G++ +     C DI
Sbjct: 252  YEL-TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI-QDALGNCIDI 309

Query: 854  NECES--NPCVNG-ACRNNLGSFNCE-----CSPGSKLSSTGLICIDSLKGTCWLNIQDS 905
            NEC S   PC  G  C N  GS+ C+     C  G  L+  G  C+D             
Sbjct: 310  NECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVD------------- 356

Query: 906  RCEVNINGATLKSECCATLGAAWGSPCE-RCELDTACP-RGLARIKGVTCEDVNECEVFP 963
                 ++     +E C        SP   RCE  T     G++R+    C DVNEC+ +P
Sbjct: 357  -----VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRM----CVDVNECQRYP 407

Query: 964  GVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMD 1023
            G     +C N+ GS+ C C  G  L   GR C DI   +C       EC +         
Sbjct: 408  GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI--NECSSSPCSQECAN--------- 456

Query: 1024 ACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPG- 1082
                     +G+            Y+  C RG   ++   V       +DI+EC    G 
Sbjct: 457  --------VYGS------------YQCYCRRGYQLSDVDGVTC-----EDIDECALPTGG 491

Query: 1083 -MCTYGKCRNTIGSFKCRC-NSGFALDMEERNCTDIDECRISPDLCG-SGICVNTPGSFE 1139
             +C+Y +C N  GSF+C C +SG+ L    RNC DIDEC      C  +  C N  G F 
Sbjct: 492  HICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFR 550

Query: 1140 C---ECFEGY-ESGFMMMKNCMD----IDECERNPLLC 1169
            C   EC E Y  S   + +   D    I  C  N + C
Sbjct: 551  CLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTC 588



 Score =  144 bits (363), Expect = 1e-33
 Identities = 118/398 (29%), Positives = 172/398 (43%), Gaps = 86/398 (21%)

Query: 273 ACQDVDECQAIPGICQ-GGNCINTVGSFECR----CPAGHKQSETTQKCEDIDEC-SIIP 326
           +C+DV+EC      C+ G +CINTVGSF C+    C  G++ +E    C+DIDEC S I 
Sbjct: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIH 271

Query: 327 GICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKM 386
                  C NT+GS+               RC  +    C SG +     Q+  G     
Sbjct: 272 NCLPDFICQNTLGSF---------------RCRPKL--QCKSGFI-----QDALGN---- 305

Query: 387 QCCCEPGRCWGIGTIPEACPVRGS---EEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFA 443
             C +   C  I      CP+  +    E    C   +P                     
Sbjct: 306 --CIDINECLSISA---PCPIGHTCINTEGSYTCQKNVPN-------------------- 340

Query: 444 PSGNGNGYGPGGTGFIPI--------PGGNGF----SPGVGGAGVGAGGQGPIITGLTIL 491
             G G      GT  + +        P G G     SPG        G       G++ +
Sbjct: 341 -CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY---FDGISRM 396

Query: 492 NQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANG-DCIDVDECTSNPCTNGDCV 550
              ++ C+ +       +C  T+ SY C C++G++   +G  C D++EC+S+PC+  +C 
Sbjct: 397 CVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ-ECA 455

Query: 551 NTPGSYYCKCHAGFQRTPTK-QACIDIDECI--QNGVLCKNGRCVNTDGSFQCIC-NAGF 606
           N  GSY C C  G+Q +      C DIDEC     G +C + RC+N  GSFQC C ++G+
Sbjct: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCPSSGY 514

Query: 607 ELTTDGKNCVDHDECTT--TNMCLNGMCINEDGSFKCI 642
            L  +G+NC D DEC T   N  +N  C N  G F+C+
Sbjct: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552



 Score = 99.0 bits (245), Expect = 6e-20
 Identities = 99/327 (30%), Positives = 134/327 (40%), Gaps = 51/327 (15%)

Query: 97  CCPGWKTLPGG------NQCIV--------PICRNSCGDGFCSRPNMCTCSSGQISSTCG 142
           C  G++ L  G      N+CI           C N+ G   C R + C  +  +++    
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG-TGYELTEDNS 259

Query: 143 SKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNG------GRCIGPNRC 196
            K I +C     N   C  D   CQ   +G++  +P  +  C++G      G CI  N C
Sbjct: 260 CKDIDECESGIHN---CLPDFI-CQNT-LGSFRCRPKLQ--CKSGFIQDALGNCIDINEC 312

Query: 197 A-----CVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLT--GIVCTKTLCCATIGRAWG- 248
                 C  G T    E  Y    C   V N      L   G  C     CA      G 
Sbjct: 313 LSISAPCPIGHTCINTEGSYT---CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGK 369

Query: 249 -HPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAG 306
            H C   P   +  C+ G+  +  +  C DV+ECQ  PG   G  C NT+GS+ C C  G
Sbjct: 370 GHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVG 429

Query: 307 HKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGY-VTSTDGSRC--IDQRT 363
            + S   + CEDI+ECS  P  C   EC+N  GSY C C RGY ++  DG  C  ID+  
Sbjct: 430 FRLSVDGRSCEDINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486

Query: 364 GMCFSGLVNGRCAQELPGRMTKMQCCC 390
                 + + RC   +PG     QC C
Sbjct: 487 LPTGGHICSYRCI-NIPG---SFQCSC 509



 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 81/299 (27%), Positives = 113/299 (37%), Gaps = 66/299 (22%)

Query: 152 RCMNGGTCADDHCQCQKGYIGTYC----GQPVCENG--CQNGGRCI-GPNRC----ACVY 200
           RC  GG C     QC+       C    G  +  +G  C++   CI G + C    +C+ 
Sbjct: 179 RCRGGGPCKQ---QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235

Query: 201 GFTGPQCERDYRTGP---------------CFTQVNNQM----CQGQLTGIVCTKTLCCA 241
                +C+RD   G                C + ++N +    CQ  L    C   L C 
Sbjct: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 242 T--IGRAWGH------------PCEM------------CPAQPQPCRRGFIPNIRTGACQ 275
           +  I  A G+            PC +            C      C RG+  N     C 
Sbjct: 296 SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 276 DVDECQAIPGIC-QGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGEC 334
           DVDEC      C +G  C+N+ GSF C C  G+     ++ C D++EC   PG     +C
Sbjct: 356 DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415

Query: 335 SNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
            NT+GSY C C  G+  S DG  C D       +   +  C+QE        QC C  G
Sbjct: 416 ENTLGSYLCSCSVGFRLSVDGRSCED------INECSSSPCSQECANVYGSYQCYCRRG 468



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 101/315 (32%), Positives = 131/315 (41%), Gaps = 83/315 (26%)

Query: 114 ICRNSCGDGFCSRPNMCTCSSGQISSTCGSK-SIQQC---SVRCMNGGTCADDH----CQ 165
           IC+N+ G   C RP +  C SG I    G+   I +C   S  C  G TC +      CQ
Sbjct: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335

Query: 166 -----CQKGYI----GTYCGQ-----PVCENGCQNGGRCI---GPNRCACVYGFTGPQCE 208
                C +GY     GT C       P  E  C  G RC+   G  RC C  G+      
Sbjct: 336 KNVPNCGRGYHLNEEGTRCVDVDECAPPAEP-CGKGHRCVNSPGSFRCECKTGY------ 388

Query: 209 RDYRTGPCFTQVNNQMCQ---GQLTGIVCTKTL----CCATIG---RAWGHPCE---MCP 255
             Y  G     V+   CQ   G+L G  C  TL    C  ++G      G  CE    C 
Sbjct: 389 --YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS 446

Query: 256 AQPQP-------------CRRGF-IPNIRTGACQDVDECQAIPG--ICQGGNCINTVGSF 299
           + P               CRRG+ + ++    C+D+DEC    G  IC    CIN  GSF
Sbjct: 447 SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSF 505

Query: 300 ECRCP-AGHKQSETTQKCEDIDECSIIPGI--CETGE-CSNTVGSYFCV---CPRGYVTS 352
           +C CP +G++ +   + C+DIDEC  + GI  C   E C N  G + C+   CP  Y  S
Sbjct: 506 QCSCPSSGYRLAPNGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCLAFECPENYRRS 563

Query: 353 --------TDGSRCI 359
                   TD  RCI
Sbjct: 564 AATLQQEKTDTVRCI 578



 Score = 68.9 bits (167), Expect = 7e-11
 Identities = 87/372 (23%), Positives = 142/372 (38%), Gaps = 83/372 (22%)

Query: 2410 CCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTM 2469
            CC DG R   HQ + C LP              Y T+ +   EC+++   C    C + +
Sbjct: 36   CCADGHRMATHQKD-CSLP--------------YATESK---ECRMVQEQC----CHSQL 73

Query: 2470 GSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPR-GYVLQEDGK 2528
                C       T IS  +  + D C+ +P   N   + T     C C   G   Q  G+
Sbjct: 74   EELHC------ATGISLAN--EQDRCA-TPHGDNASLEATFVKRCCHCCLLGRAAQAQGQ 124

Query: 2529 TCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGIC 2588
            +C+                 + + G+ C            C+ + E G         G  
Sbjct: 125  SCE----------------YSLMVGYQCG-----QVFRACCVKSQETGDLDV-----GGL 158

Query: 2589 QNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQ 2648
            Q T      E ++    +   LN    D C G   C+  C++      C C  GY     
Sbjct: 159  QETDKIIEVEEEQ----EDPYLN----DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSD 210

Query: 2649 WNQCVDENEC-SNPNACG-SASCYNTLGSYKC----ACPSGFSFDQFSSACHDVNECSSS 2702
               C D NEC +  ++C    SC NT+GS++C    +C +G+   +  ++C D++EC S 
Sbjct: 211  GVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESG 269

Query: 2703 KNPC--NYGCSNTEGGYLC----GCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENA 2756
             + C  ++ C NT G + C     C  G+ +   G+C+     N+   +S    +     
Sbjct: 270  IHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCID---INECLSISAPCPIG-HTC 325

Query: 2757 LSPEACYECKIN 2768
            ++ E  Y C+ N
Sbjct: 326  INTEGSYTCQKN 337


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score =  233 bits (595), Expect = 2e-60
 Identities = 243/919 (26%), Positives = 361/919 (39%), Gaps = 218/919 (23%)

Query: 1301 NIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKK 1360
            N    ++ L + G +A ++++  +    CD N       +    +  F  H       + 
Sbjct: 173  NPEDRWKSLHFSGHVAHLELQIRV---RCDENYYSATCNKFCRPRNDFFGHYTCD---QY 226

Query: 1361 GTTGCTDV---DECE--IGAHNCDM-HASCLNIPGSFKCSCREGWIGNGI-KCIDLDECS 1413
            G   C D     EC+  +    C++ H  C  +PG  +C C  GW G    +C+    C 
Sbjct: 227  GNKACMDGWMGKECKEAVCKQGCNLLHGGC-TVPG--ECRCSYGWQGRFCDECVPYPGCV 283

Query: 1414 NGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCS-DVDECAENINLCENGQCLNV-PGA 1471
            +G+        CV     ++C C   +   G  C  D++ C  +      G C+N  P  
Sbjct: 284  HGS--------CVEP---WQCNCETNW--GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQ 330

Query: 1472 YRCECEMGFTPASDSRSCQDIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRTGGNC 1530
            YRC C  G++     R+C+  +     N C  G +C+ +P  F C C  G+    +G  C
Sbjct: 331  YRCTCPDGYS----GRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGW----SGPTC 382

Query: 1531 T-DIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDG 1589
              DIDECA       G CV+    +EC CP  +     G  C                  
Sbjct: 383  ALDIDECASNPCAAGGTCVDQVDGFECICPEQW----VGATC------------------ 420

Query: 1590 SLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILE 1649
                  ++ V   R  C        G  C+    VN   Y  +CP G G R   +     
Sbjct: 421  ------QLDVNDCRGQC------QHGGTCKDL--VNG--YQCVCPRGFGGRHCEL----- 459

Query: 1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICE-DIDECFAHPGVCGPGT- 1707
            + DEC   P    GG C +    F C CPQG+       +CE D+D C   P  C  G  
Sbjct: 460  ERDECASSP-CHSGGLCEDLADGFHCHCPQGF----SGPLCEVDVDLC--EPSPCRNGAR 512

Query: 1708 CYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYN 1767
            CYN  G+Y C CP ++    GG NC                                   
Sbjct: 513  CYNLEGDYYCACPDDF----GGKNC----------------------------------- 533

Query: 1768 VGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGV---- 1823
                 + P EPC  PG A     C  I G   D   G          +PG  A+GV    
Sbjct: 534  -----SVPREPC--PGGA-----CRVIDGCGSDAGPG----------MPGTAASGVCGPH 571

Query: 1824 --CINQI-GSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAA 1880
              C++Q  G+F C C +GF+        E+ID+C      C+    CI+   ++RC C +
Sbjct: 572  GRCVSQPGGNFSCICDSGFTGT---YCHENIDDCLG--QPCRNGGTCIDEVDAFRCFCPS 626

Query: 1881 GFKLSPNGACVDRNECLEIPNVC-SHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECE 1939
            G++    G   D N    +P+ C S G C DL   + C C +G+K    +T      +C+
Sbjct: 627  GWE----GELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKG---KTCHSREFQCD 679

Query: 1940 RHPCGN-GTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFK 1998
             + C N GTC ++  ++ C C PG++    + C      S         G C     SF 
Sbjct: 680  AYTCSNGGTCYDSGDTFRCACPPGWK---GSTCAVAKNSSCLPNPCVNGGTCVGSGASFS 736

Query: 1999 CLCNEGYELTPDGKNCI-DTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENC-ID 2056
            C+C +G+E    G+ C  +TN+C  LP   + G C +    FRC C PG+     +C I+
Sbjct: 737  CICRDGWE----GRTCTHNTNDCNPLP-CYNGGICVDGVNWFRCECAPGF--AGPDCRIN 789

Query: 2057 INECDEDPNICLFG-SCTNTPGGFQCLCPPGFV------LSDNGRRCFDTRQSFCFTNFE 2109
            I+EC   P  C +G +C +   G++C CPPG        +   GR C+     F   +  
Sbjct: 790  IDECQSSP--CAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSW 847

Query: 2110 NGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTR 2169
               C+  +  +  +    CSK+   GW  PC L  + + ++ Q  CP G           
Sbjct: 848  VEDCNSCRCLDGRRD---CSKV-WCGW-KPCLLAGQPEALSAQ--CPLG----------- 889

Query: 2170 EDVNECLE-SPGICSNGQC 2187
                 CLE +PG C    C
Sbjct: 890  ---QRCLEKAPGQCLRPPC 905



 Score =  191 bits (486), Expect = 7e-48
 Identities = 182/660 (27%), Positives = 260/660 (39%), Gaps = 111/660 (16%)

Query: 695  RVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYG-FGEPCQPCPAKNSAEFH 753
            + C+D  M   C   + K  C     G     EC C+    G F + C P P       H
Sbjct: 229  KACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGC----VH 284

Query: 754  GLC---------SSGVGITVDGRDINECALDPDICANGICENLR-GSYRCNCNSGYEPDA 803
            G C         ++  G+  D +D+N C         G C N     YRC C  GY    
Sbjct: 285  GSCVEPWQCNCETNWGGLLCD-KDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY---- 339

Query: 804  SGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCE-DINECESNPC- 861
            SGRNC   +    +    + G C   P  + C CP G+       TC  DI+EC SNPC 
Sbjct: 340  SGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGW----SGPTCALDIDECASNPCA 395

Query: 862  VNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNING-------- 913
              G C + +  F C C P   + +T  + ++  +G C        C+  +NG        
Sbjct: 396  AGGTCVDQVDGFECIC-PEQWVGATCQLDVNDCRGQCQ---HGGTCKDLVNGYQCVCPRG 451

Query: 914  -----ATLKSECCATLGAAWGSPCERCE--LDTACPRGLARIKGVTCE-DVNECEVFPGV 965
                   L+ + CA+     G  CE         CP+G +   G  CE DV+ CE  P  
Sbjct: 452  FGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFS---GPLCEVDVDLCE--PSP 506

Query: 966  CPNG-RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDA 1024
            C NG RC N +G ++C CP+    D  G+ C   R               P PG      
Sbjct: 507  CRNGARCYNLEGDYYCACPD----DFGGKNCSVPR--------------EPCPGG----- 543

Query: 1025 CCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRG--------DVLTGRPFYKDINE 1076
              C V    G++      PGT       P G   +  G           TG   +++I++
Sbjct: 544  -ACRVIDGCGSDAGP-GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDD 601

Query: 1077 CKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGS-GICVNTP 1135
            C   P     G C + + +F+C C SG+  ++ + N  D       PD C S G C +  
Sbjct: 602  CLGQP-CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPND-----CLPDPCHSRGRCYDLV 655

Query: 1136 GSFECECFEGYESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEGSFQCDCPLGHELSPS 1194
              F C C +G++      K C    E + +   C  GGTC ++  +F+C CP G + S  
Sbjct: 656  NDFYCACDDGWKG-----KTCHS-REFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGS-- 707

Query: 1195 REDCVDINECSLSDNLCRN-GKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGC 1253
               C      S   N C N G CV    ++ C C  G++         D +     NGG 
Sbjct: 708  --TCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGI 765

Query: 1254 DTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDG 1313
               C +    + C C+ G+A  PD R   +IDEC+++P    G  C +    YRC C  G
Sbjct: 766  ---CVDGVNWFRCECAPGFA-GPDCR--INIDECQSSP-CAYGATCVDEINGYRCSCPPG 818



 Score =  190 bits (483), Expect = 2e-47
 Identities = 161/599 (26%), Positives = 238/599 (39%), Gaps = 119/599 (19%)

Query: 2170 EDVNECLESPGICSNGQCINTD-GSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNG-T 2227
            +D+N C       + G CIN +   +RC CP GY+    G  C   +     NPC NG +
Sbjct: 306  KDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYS----GRNCEKAEHACTSNPCANGGS 361

Query: 2228 CTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCP---IGYA 2284
            C  V   FEC+C  G+  GP     DI+ECA NP      C++    +EC CP   +G  
Sbjct: 362  CHEVPSGFECHCPSGWS-GPTCAL-DIDECASNPCAAGGTCVDQVDGFECICPEQWVGAT 419

Query: 2285 LREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECR 2343
             + D   C+           C+  G  CK+L+  + C+CP G      G  C ++ +EC 
Sbjct: 420  CQLDVNDCRG---------QCQHGGT-CKDLVNGYQCVCPRGFG----GRHCELERDECA 465

Query: 2344 TKPGICENGR-CVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSR 2402
            + P  C +G  C ++   + C C +GF    SG  C +    LC        C+  +   
Sbjct: 466  SSP--CHSGGLCEDLADGFHCHCPQGF----SGPLC-EVDVDLCEPSP----CRNGARCY 514

Query: 2403 NLVTKSECCCD---GGRGWGHQCELCP-----------------LPGTAQYKKICPHGPG 2442
            NL     C C    GG+      E CP                 +PGTA      PHG  
Sbjct: 515  NLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRC 574

Query: 2443 YTTDG-----------------RDIDECKVMPNLCTNG-QCINTMGSFRCFCKVGYTTDI 2484
             +  G                  +ID+C   P  C NG  CI+ + +FRCFC  G+  ++
Sbjct: 575  VSQPGGNFSCICDSGFTGTYCHENIDDCLGQP--CRNGGTCIDEVDAFRCFCPSGWEGEL 632

Query: 2485 SGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLD-ECQTKQHNC 2543
              T+  D   C   P      C +    + C+C  G+     GKTC   + +C     + 
Sbjct: 633  CDTNPND---CLPDPCHSRGRCYDLVNDFYCACDDGW----KGKTCHSREFQCDAYTCSN 685

Query: 2544 QFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGF 2603
               C ++   F C CPPG+     A   N+ C   P + G  G C  +  SFSC C+ G+
Sbjct: 686  GGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNG--GTCVGSGASFSCICRDGW 743

Query: 2604 SLDATGLNCEDVDECDGNHRCQHG--CQNILGGYRCGCPQGYIQHYQWNQC-VDENECSN 2660
                   N  D +       C +G  C + +  +RC C  G+        C ++ +EC +
Sbjct: 744  EGRTCTHNTNDCNPLP----CYNGGICVDGVNWFRCECAPGFAGP----DCRINIDECQS 795

Query: 2661 PNACGSASCYNTLGSYKCACPSGFS--------------------FDQFSSACHDVNEC 2699
                  A+C + +  Y+C+CP G +                    F   SS   D N C
Sbjct: 796  SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSC 854



 Score =  184 bits (468), Expect = 8e-46
 Identities = 193/734 (26%), Positives = 277/734 (37%), Gaps = 155/734 (21%)

Query: 1677 CPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMD-M 1735
            C + YY +   + C   ++ F H       TC +  GN  C      M    G  C + +
Sbjct: 198  CDENYYSATCNKFCRPRNDFFGHY------TC-DQYGNKAC------MDGWMGKECKEAV 244

Query: 1736 RKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEP--------CPTPGTADF 1787
             K  C   + G T   E         C C+Y     +   C P        C  P   + 
Sbjct: 245  CKQGCNLLHGGCTVPGE---------CRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNC 295

Query: 1788 KTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCIN-QIGSFRCECPTGFSYNDLLL 1846
            +T  G   G   D       D++ C         G CIN +   +RC CP G+S  +   
Sbjct: 296  ETNWG---GLLCD------KDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN--- 343

Query: 1847 VCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHG 1906
             CE  +      N C     C   P  + C C +G+  S     +D +EC   P   + G
Sbjct: 344  -CEKAEHACTS-NPCANGGSCHEVPSGFECHCPSGW--SGPTCALDIDECASNP-CAAGG 398

Query: 1907 LCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELT 1966
             CVD    ++CIC   +  +  Q   +DV++C       GTCK+ V  Y C+C  GF   
Sbjct: 399  TCVDQVDGFECICPEQWVGATCQ---LDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGR 455

Query: 1967 HNNDCLDIDECSSFFGQVCRN-GRCFNEIGSFKCLCNEGYELTPDGKNC-IDTNECVALP 2024
            H    L+ DEC+S     C + G C +    F C C +G+     G  C +D + C   P
Sbjct: 456  HCE--LERDECAS---SPCHSGGLCEDLADGFHCHCPQGF----SGPLCEVDVDLCE--P 504

Query: 2025 GSCSPGT-CQNLEGSFRCICPPGYEVKSEN----------CIDINECDED---------- 2063
              C  G  C NLEG + C CP  +  K+ +          C  I+ C  D          
Sbjct: 505  SPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAA 564

Query: 2064 PNIC-LFGSCTNTPGG-FQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNT 2121
              +C   G C + PGG F C+C  GF              ++C  N ++           
Sbjct: 565  SGVCGPHGRCVSQPGGNFSCICDSGFT------------GTYCHENIDD----------- 601

Query: 2122 TKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGI 2181
                  C   P    G  C     D+  AF+  CP   G    L DT  + N+CL  P  
Sbjct: 602  ------CLGQPCRN-GGTC----IDEVDAFRCFCP--SGWEGELCDT--NPNDCLPDP-C 645

Query: 2182 CSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTD-ECSIGNPCGNGTCTNVIGSFECNCN 2240
             S G+C +    F C C  G+     G  C   + +C        GTC +   +F C C 
Sbjct: 646  HSRGRCYDLVNDFYCACDDGWK----GKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACP 701

Query: 2241 EGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAE 2300
             G++ G        + C  NP +    C+ +  S+ C C  G+  R           C  
Sbjct: 702  PGWK-GSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGR----------TCTH 750

Query: 2301 GLHDCES----RGMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECRTKPGICENG-RC 2354
              +DC       G +C + +  F C C PG A    G  C ++ +EC++ P  C  G  C
Sbjct: 751  NTNDCNPLPCYNGGICVDGVNWFRCECAPGFA----GPDCRINIDECQSSP--CAYGATC 804

Query: 2355 VNIIGSYRCECNEG 2368
            V+ I  YRC C  G
Sbjct: 805  VDEINGYRCSCPPG 818



 Score =  177 bits (450), Expect = 1e-43
 Identities = 177/673 (26%), Positives = 260/673 (38%), Gaps = 139/673 (20%)

Query: 85  GPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCG--DGFCSRPNMCTCSSGQISSTCG 142
           G   C    +  C  GW     G +C   +C+  C    G C+ P  C CS G     C 
Sbjct: 219 GHYTCDQYGNKACMDGWM----GKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFC- 273

Query: 143 SKSIQQCSVR--CMNGGTCADDHCQCQKGYIGTYCGQPVCENG----CQNGGRCIGPN-- 194
                +C     C++G       C C+  + G  C + +   G    C NGG CI     
Sbjct: 274 ----DECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPD 329

Query: 195 --RCACVYGFTGPQCERDYR---TGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGH 249
             RC C  G++G  CE+      + PC    N   C    +G  C     C +    W  
Sbjct: 330 QYRCTCPDGYSGRNCEKAEHACTSNPC---ANGGSCHEVPSGFECH----CPS---GWSG 379

Query: 250 PCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQ 309
           P                         D+DEC + P    GG C++ V  FEC CP    +
Sbjct: 380 PT---------------------CALDIDECASNP-CAAGGTCVDQVDGFECICP----E 413

Query: 310 SETTQKCE-DIDECSIIPGICETG-ECSNTVGSYFCVCPRGYVTSTDGSRCIDQR----T 363
                 C+ D+++C    G C+ G  C + V  Y CVCPRG+     G  C  +R    +
Sbjct: 414 QWVGATCQLDVNDCR---GQCQHGGTCKDLVNGYQCVCPRGF----GGRHCELERDECAS 466

Query: 364 GMCFSG-----LVNG---RCAQELPGRMTKMQC-CCEPG------RCWGI-GTIPEACPV 407
             C SG     L +G    C Q   G + ++    CEP       RC+ + G    ACP 
Sbjct: 467 SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACP- 525

Query: 408 RGSEEYRRLCMDGLPMGGIPGSAGSRPGGTG---GNGFAPSGNGNGYGPGGTGFIPIPGG 464
              +   + C   +P    PG A     G G   G G   +      GP G   +  PGG
Sbjct: 526 --DDFGGKNC--SVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGR-CVSQPGG 580

Query: 465 N-------GFSPGVGGAGVGAGGQGPIITGLTILNQTI------------DICKHHANLC 505
           N       GF+       +      P   G T +++              ++C  + N C
Sbjct: 581 NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC 640

Query: 506 L------NGRCIPTVSSYRCECNMGYKQDANGDCIDVD-ECTSNPCTNGD-CVNTPGSYY 557
           L       GRC   V+ + C C+ G+K      C   + +C +  C+NG  C ++  ++ 
Sbjct: 641 LPDPCHSRGRCYDLVNDFYCACDDGWKGKT---CHSREFQCDAYTCSNGGTCYDSGDTFR 697

Query: 558 CKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVD 617
           C C  G++ +    A      C+ N  +   G CV +  SF CIC  G+E    G+ C  
Sbjct: 698 CACPPGWKGSTC--AVAKNSSCLPNPCV-NGGTCVGSGASFSCICRDGWE----GRTCTH 750

Query: 618 HDECTTTNMCLNG-MCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINS 676
           +        C NG +C++    F+C C PGF   P+ R   ++DECQ+        C++ 
Sbjct: 751 NTNDCNPLPCYNGGICVDGVNWFRCECAPGFA-GPDCRI--NIDECQSSPCAYGATCVDE 807

Query: 677 EGSFRCDCPPGLA 689
              +RC CPPG A
Sbjct: 808 INGYRCSCPPGRA 820



 Score =  176 bits (447), Expect = 2e-43
 Identities = 190/706 (26%), Positives = 272/706 (38%), Gaps = 157/706 (22%)

Query: 1910 DLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYN----CLCYPGFEL 1965
            D  G Y C  + G KA  D  M     EC+   C  G C    G       C C  G++ 
Sbjct: 216  DFFGHYTCDQY-GNKACMDGWMGK---ECKEAVCKQG-CNLLHGGCTVPGECRCSYGWQ- 269

Query: 1966 THNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCI-DTNECVALP 2024
                 C   DEC  + G  C +G C   +  ++C C   +     G  C  D N C +  
Sbjct: 270  --GRFC---DECVPYPG--CVHGSC---VEPWQCNCETNW----GGLLCDKDLNYCGSHH 315

Query: 2025 GSCSPGTCQNLE-GSFRCICPPGYE----VKSENCIDINECDEDPNICLFGSCTNTPGGF 2079
               + GTC N E   +RC CP GY      K+E+    N C         GSC   P GF
Sbjct: 316  PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANG------GSCHEVPSGF 369

Query: 2080 QCLCPPGFVLSDNGRRC-FDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGD 2138
            +C CP G+    +G  C  D  +         G C           +C C   P +  G 
Sbjct: 370  ECHCPSGW----SGPTCALDIDECASNPCAAGGTC----VDQVDGFECIC---PEQWVGA 418

Query: 2139 PCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNG-QCINTDGSFRCE 2197
             C+L                            DVN+C    G C +G  C +    ++C 
Sbjct: 419  TCQL----------------------------DVNDCR---GQCQHGGTCKDLVNGYQCV 447

Query: 2198 CPMGYNLDYTGVRC-VDTDECSIGNPC-GNGTCTNVIGSFECNCNEGFEPGPMMNCE-DI 2254
            CP G+     G  C ++ DEC+  +PC   G C ++   F C+C +GF  GP+  CE D+
Sbjct: 448  CPRGFG----GRHCELERDECA-SSPCHSGGLCEDLADGFHCHCPQGFS-GPL--CEVDV 499

Query: 2255 NECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQK--------MCKDLDEC-------- 2298
            + C  +P     RC N  G Y C CP  +  +             C+ +D C        
Sbjct: 500  DLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGM 559

Query: 2299 ----AEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDE-NECRTKPGICENG- 2352
                A G+  C   G       G F CIC  G      G  C +  ++C  +P  C NG 
Sbjct: 560  PGTAASGV--CGPHGRCVSQPGGNFSCICDSGFT----GTYCHENIDDCLGQP--CRNGG 611

Query: 2353 RCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCC 2412
             C++ + ++RC C  G++      E  D     C  +     C       +LV    C C
Sbjct: 612  TCIDEVDAFRCFCPSGWEG-----ELCDTNPNDCLPDP----CHSRGRCYDLVNDFYCAC 662

Query: 2413 DGG------RGWGHQCEL--CPLPGTAQ-----YKKICPHG-PGYTTDGRDIDECKVMPN 2458
            D G           QC+   C   GT       ++  CP G  G T        C  +PN
Sbjct: 663  DDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC--LPN 720

Query: 2459 LCTNG-QCINTMGSFRCFCKVGYTTDISGTSCI-DLDECSQSPKPCNYICKNTEGSYQCS 2516
             C NG  C+ +  SF C C+ G+     G +C  + ++C+  P     IC +    ++C 
Sbjct: 721  PCVNGGTCVGSGASFSCICRDGW----EGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCE 776

Query: 2517 CPRGYVLQEDGKTCK-DLDECQTKQHNCQFLCVNTLGGFTCKCPPG 2561
            C  G+     G  C+ ++DECQ+        CV+ + G+ C CPPG
Sbjct: 777  CAPGFA----GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG 818



 Score =  164 bits (414), Expect = 2e-39
 Identities = 191/741 (25%), Positives = 281/741 (37%), Gaps = 179/741 (24%)

Query: 1136 GSFECE------CFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGH 1189
            G + C+      C +G+     M K C +   C++   L  GG  V  E    C C  G 
Sbjct: 219  GHYTCDQYGNKACMDGW-----MGKECKEA-VCKQGCNLLHGGCTVPGE----CRCSYGW 268

Query: 1190 ELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNP---GYQATPDRQGCTDIDEC 1246
            +     ++CV    C        +G CV     +QC+C     G     D   C     C
Sbjct: 269  Q-GRFCDECVPYPGCV-------HGSCVE---PWQCNCETNWGGLLCDKDLNYCGSHHPC 317

Query: 1247 MIMNGGCDTQCTNSE-GSYECSCSEGYALMPDGRSCADIDE-CENNPDICDGGQCTNIPG 1304
               NGG    C N+E   Y C+C +GY+    GR+C   +  C +NP   +GG C  +P 
Sbjct: 318  T--NGGT---CINAEPDQYRCTCPDGYS----GRNCEKAEHACTSNP-CANGGSCHEVPS 367

Query: 1305 EYRCLCYDGFMASMDMKTC-IDVNECDLNSNICMF-GECENTKGSFICHCQLGYSVKKGT 1362
             + C C  G+       TC +D++EC   SN C   G C +    F C C   +    G 
Sbjct: 368  GFECHCPSGWSG----PTCALDIDEC--ASNPCAAGGTCVDQVDGFECICPEQW---VGA 418

Query: 1363 TGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSIN 1422
            T   DV++C      C    +C ++   ++C C  G+ G   + ++ DEC++    C   
Sbjct: 419  TCQLDVNDCR---GQCQHGGTCKDLVNGYQCVCPRGFGGRHCE-LERDECASS--PCHSG 472

Query: 1423 AQCVNTPGSYRCACSEGFTGDGFTCS-DVDECAENINLCENG-QCLNVPGAYRCECEMGF 1480
              C +    + C C +GF+G    C  DVD C    + C NG +C N+ G Y C C   F
Sbjct: 473  GLCEDLADGFHCHCPQGFSGP--LCEVDVDLCEP--SPCRNGARCYNLEGDYYCACPDDF 528

Query: 1481 TPASDS--------RSCQDIDEC-----------SFQNIC-VFGTCNNLP-GMFHCICDD 1519
               + S         +C+ ID C           +   +C   G C + P G F CICD 
Sbjct: 529  GGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDS 588

Query: 1520 GYELDRTGGNC-TDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGN 1578
            G+    TG  C  +ID+C        G C++    + C CP  ++    G  C D    +
Sbjct: 589  GF----TGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWE----GELC-DTNPND 639

Query: 1579 CYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEG 1638
            C                           C S G+ +         VN  ++Y  C  G  
Sbjct: 640  CL-----------------------PDPCHSRGRCY-------DLVN--DFYCACDDGWK 667

Query: 1639 FRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFA 1698
             +         D   C        GG C ++  +F+C CP G+     T        C  
Sbjct: 668  GKTCHSREFQCDAYTCS------NGGTCYDSGDTFRCACPPGW--KGSTCAVAKNSSCLP 719

Query: 1699 HPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVT 1758
            +P V G GTC  +  +++CIC   +      HN  D     C   YNG  C +       
Sbjct: 720  NPCVNG-GTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC---YNGGICVD------- 768

Query: 1759 KRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGI 1818
                      G  W + CE  P     D +                  ++IDEC+  P  
Sbjct: 769  ----------GVNWFR-CECAPGFAGPDCR------------------INIDECQSSP-- 797

Query: 1819 CANG-VCINQIGSFRCECPTG 1838
            CA G  C+++I  +RC CP G
Sbjct: 798  CAYGATCVDEINGYRCSCPPG 818



 Score =  132 bits (332), Expect = 5e-30
 Identities = 100/313 (31%), Positives = 144/313 (46%), Gaps = 52/313 (16%)

Query: 2425 CPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDI 2484
            C +PG  +    C +G      GR  DEC   P  C +G C+     ++C C+    T+ 
Sbjct: 256  CTVPGECR----CSYG----WQGRFCDECVPYPG-CVHGSCVEP---WQCNCE----TNW 299

Query: 2485 SGTSCI-DLDECSQSPKPCNY--ICKNTE-GSYQCSCPRGYVLQEDGKTCKDLDE-CQTK 2539
             G  C  DL+ C  S  PC     C N E   Y+C+CP GY     G+ C+  +  C + 
Sbjct: 300  GGLLCDKDLNYCG-SHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNCEKAEHACTSN 354

Query: 2540 QHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCEC 2599
                   C     GF C CP G++   T  +D +EC S P  C A G C +    F C C
Sbjct: 355  PCANGGSCHEVPSGFECHCPSGWSGP-TCALDIDECASNP--CAAGGTCVDQVDGFECIC 411

Query: 2600 QRGFSLDATGLNCE-DVDECDGNHRCQHG--CQNILGGYRCGCPQGY-IQHYQWNQCVDE 2655
               +     G  C+ DV++C G  +CQHG  C++++ GY+C CP+G+  +H +    ++ 
Sbjct: 412  PEQW----VGATCQLDVNDCRG--QCQHGGTCKDLVNGYQCVCPRGFGGRHCE----LER 461

Query: 2656 NECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACH-DVNECSSSKNPCNYG--CSN 2712
            +EC++        C +    + C CP GFS       C  DV+ C  S  PC  G  C N
Sbjct: 462  DECASSPCHSGGLCEDLADGFHCHCPQGFS----GPLCEVDVDLCEPS--PCRNGARCYN 515

Query: 2713 TEGGYLCGCPPGY 2725
             EG Y C CP  +
Sbjct: 516  LEGDYYCACPDDF 528



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 38/133 (28%), Positives = 50/133 (37%), Gaps = 14/133 (10%)

Query: 90  GSRFHSYCCPGWK----TLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKS 145
           G  F   C PGWK     +   + C+   C N            C C  G    TC   +
Sbjct: 693 GDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNT 752

Query: 146 IQQCSVRCMNGGTCADD----HCQCQKGYIGTYCGQPVCE---NGCQNGGRC---IGPNR 195
                + C NGG C D      C+C  G+ G  C   + E   + C  G  C   I   R
Sbjct: 753 NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYR 812

Query: 196 CACVYGFTGPQCE 208
           C+C  G  GP+C+
Sbjct: 813 CSCPPGRAGPRCQ 825


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  232 bits (592), Expect = 4e-60
 Identities = 161/490 (32%), Positives = 238/490 (48%), Gaps = 65/490 (13%)

Query: 1834 ECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG-ACVD 1892
            +CP+GF+ + +   C D DEC+ G N C  +  C N+ G+Y C C  G  ++ +G  C D
Sbjct: 5091 QCPSGFTLDSVGPFCADEDECAAG-NPCSHS--CHNAMGTYYCSCPKGLTIAADGRTCQD 5147

Query: 1893 RNECLEIPNVCSHGL-CVDLQGSYQCI--CHNGFKASQDQTMCMDVDEC-ERHPCGNGTC 1948
             +EC    + C  G  C +  GSY+C+  C +GF+ + D   C D++EC E  PC +  C
Sbjct: 5148 IDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPC-HQRC 5206

Query: 1949 KNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCR-NGRCFNEIGSFKC--LCNEGY 2005
             N +GS++C C PG++L     C+D++EC      VCR +  C N  G +KC  LC  G 
Sbjct: 5207 FNAIGSFHCGCEPGYQL-KGRKCMDVNECRQ---NVCRPDQHCKNTRGGYKCIDLCPNGM 5262

Query: 2006 ELTPDGKNCIDTNECVALPGSCSPG-TCQNLEGSFRCICPPGYEVK--SENCIDINECDE 2062
                +G  CID +EC      C     C+N  GS+RC+CP GY  +     C+DINEC++
Sbjct: 5263 TKAENG-TCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQ 5321

Query: 2063 DPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKA-FNT 2121
             P  C    C+NTPG F+C+CPPG  L  +G+ C    +     N+     S   A F+ 
Sbjct: 5322 VPKPCAH-QCSNTPGSFKCICPPGQHLLGDGKSCAGLER---LPNYGTQYSSYNLARFSP 5377

Query: 2122 TKAKCCCSKMPGEGWGDPCELCPKDDEV------------AFQDLCPYGHGTVPSLHDTR 2169
             +     +  P + +     L     E               +  CP G     + HDT 
Sbjct: 5378 VRN----NYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGS---EASHDTC 5430

Query: 2170 EDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGN-PCG-NGT 2227
             D++EC E+   C + +C NT GS++C CP GY L + G  C D DEC   N  CG N  
Sbjct: 5431 VDIDEC-ENTDACQH-ECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRM 5488

Query: 2228 CTNVIGSFEC---NCNEGFEPGP-----MMNCEDIN-ECAQNPLLCAFRCMNTFGSYECT 2278
            C N+ GS++C    C   ++  P     + NC   + ECA +P    ++ +        +
Sbjct: 5489 CFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLV--------S 5540

Query: 2279 CPIGYALRED 2288
             P G A  +D
Sbjct: 5541 LPFGIATNQD 5550



 Score =  232 bits (591), Expect = 5e-60
 Identities = 152/437 (34%), Positives = 206/437 (47%), Gaps = 68/437 (15%)

Query: 1156 CMDIDECER-NPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNG 1214
            C D DEC   NP      +C N  G++ C CP G  ++     C DI+EC+L  + C  G
Sbjct: 5105 CADEDECAAGNPC---SHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAG 5161

Query: 1215 K-CVNMIGTYQC--SCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEG 1271
            + C N IG+Y+C   C  G++ T D   C DI+EC   +  C  +C N+ GS+ C C  G
Sbjct: 5162 QDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQ-ESSPCHQRCFNAIGSFHCGCEPG 5220

Query: 1272 YALMPDGRSCADIDECENNPDICDGGQ-CTNIPGEYRC--LCYDGFMASMDMKTCIDVNE 1328
            Y L   GR C D++EC  N  +C   Q C N  G Y+C  LC +G M   +  TCID++E
Sbjct: 5221 YQLK--GRKCMDVNECRQN--VCRPDQHCKNTRGGYKCIDLCPNG-MTKAENGTCIDIDE 5275

Query: 1329 CDLNSNICMFGE-CENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNI 1387
            C   ++ C + + CENT+GS+ C C  GY  +     C D++ECE     C     C N 
Sbjct: 5276 CKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQ--CSNT 5333

Query: 1388 PGSFKCSCREGW--IGNGIKCIDLDECSN-GTHQCSIN---------------------- 1422
            PGSFKC C  G   +G+G  C  L+   N GT   S N                      
Sbjct: 5334 PGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSH 5393

Query: 1423 ------------AQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPG 1470
                             T  + R  C EG      TC D+DEC EN + C++ +C N  G
Sbjct: 5394 LYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDEC-ENTDACQH-ECKNTFG 5451

Query: 1471 AYRCECEMGFTPASDSRSCQDIDECSFQNICVFGT--CNNLPGMFHCI---CDDGYELDR 1525
            +Y+C C  G+    + ++CQDIDEC  QN+       C N+ G + CI   C   Y+ D 
Sbjct: 5452 SYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDP 5511

Query: 1526 TGG----NCTDID-ECA 1537
              G    NC   D ECA
Sbjct: 5512 VSGFCLKNCPPNDLECA 5528



 Score =  231 bits (588), Expect = 1e-59
 Identities = 154/457 (33%), Positives = 206/457 (45%), Gaps = 93/457 (20%)

Query: 2239 CNEGF---EPGPMMNCEDINECAQ-NPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKD 2294
            C  GF     GP   C D +ECA  NP  C+  C N  G+Y C+CP G  +  D + C+D
Sbjct: 5092 CPSGFTLDSVGPF--CADEDECAAGNP--CSHSCHNAMGTYYCSCPKGLTIAADGRTCQD 5147

Query: 2295 LDECAEGLHDCESRGMMCKNLIGTFMCI--CPPGMARRPDGEGCVDENECRTKPGICENG 2352
            +DECA G H C + G  C N IG++ C+  C  G  R  DG  C D NEC+ +   C   
Sbjct: 5148 IDECALGRHTCHA-GQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQ-ESSPCHQ- 5204

Query: 2353 RCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCC 2412
            RC N IGS+ C C  G+Q    G +C+D        E  Q +C           + +  C
Sbjct: 5205 RCFNAIGSFHCGCEPGYQLK--GRKCMDVN------ECRQNVC-----------RPDQHC 5245

Query: 2413 DGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR--DIDECKVMPNLCTNGQ-CINTM 2469
               RG G++C             +CP+G     +G   DIDECK   + C   Q C NT 
Sbjct: 5246 KNTRG-GYKCI-----------DLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTR 5293

Query: 2470 GSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKT 2529
            GS+RC C  GY +   G  C+D++EC Q PKPC + C NT GS++C CP G  L  DGK+
Sbjct: 5294 GSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKS 5353

Query: 2530 CKDLDEC----------------------QTKQH---------------NCQFLCVNTLG 2552
            C  L+                        Q +QH               N +     T  
Sbjct: 5354 CAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRR 5413

Query: 2553 GFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNC 2612
                 CP G    H  C+D +EC +  +    +  C+NT GS+ C C  G+ L   G  C
Sbjct: 5414 TIRKTCPEGSEASHDTCVDIDECENTDA---CQHECKNTFGSYQCICPPGYQLTHNGKTC 5470

Query: 2613 EDVDEC-DGNHRC--QHGCQNILGGYRC---GCPQGY 2643
            +D+DEC + N  C     C N+ G Y+C    CP  Y
Sbjct: 5471 QDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNY 5507



 Score =  227 bits (578), Expect = 1e-58
 Identities = 144/449 (32%), Positives = 202/449 (44%), Gaps = 64/449 (14%)

Query: 1177 TEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPD 1236
            ++G     CP G  L      C D +EC+ + N C +  C N +GTY CSC  G     D
Sbjct: 5084 SKGDRSNQCPSGFTLDSVGPFCADEDECA-AGNPCSHS-CHNAMGTYYCSCPKGLTIAAD 5141

Query: 1237 RQGCTDIDECMIMNGGCDT--QCTNSEGSYEC--SCSEGYALMPDGRSCADIDECENNPD 1292
             + C DIDEC +    C     C N+ GSY C   C  G+    DG SC DI+EC+ +  
Sbjct: 5142 GRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSP 5201

Query: 1293 ICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGE-CENTKGSFICH 1351
                 +C N  G + C C  G+   +  + C+DVNEC    N+C   + C+NT+G + C 
Sbjct: 5202 CHQ--RCFNAIGSFHCGCEPGYQ--LKGRKCMDVNEC--RQNVCRPDQHCKNTRGGYKCI 5255

Query: 1352 CQLGYSVKKGTTG-CTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGI--KCID 1408
                  + K   G C D+DEC+ G H C  +  C N  GS++C C  G+   G+   C+D
Sbjct: 5256 DLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMD 5315

Query: 1409 LDECSNGTHQCSINAQCVNTPGSYRCACSEG--FTGDGFTCSDVDECAE------NINLC 1460
            ++EC      C+   QC NTPGS++C C  G    GDG +C+ ++          + NL 
Sbjct: 5316 INECEQVPKPCA--HQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLA 5373

Query: 1461 ENGQCLN------------------------------VPGAYRCECEMGFTPASDSRSCQ 1490
                  N                                   R  C  G   + D+  C 
Sbjct: 5374 RFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDT--CV 5431

Query: 1491 DIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADP-INC-VNGLCV 1548
            DIDEC   + C    C N  G + CIC  GY+L   G  C DIDEC +  ++C  N +C 
Sbjct: 5432 DIDECENTDACQH-ECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCF 5490

Query: 1549 NTPGRYEC---NCPPDFQLNPTGVGCVDN 1574
            N  G Y+C    CPP++Q +P    C+ N
Sbjct: 5491 NMRGSYQCIDTPCPPNYQRDPVSGFCLKN 5519



 Score =  223 bits (567), Expect = 3e-57
 Identities = 153/472 (32%), Positives = 199/472 (42%), Gaps = 104/472 (22%)

Query: 2279 CPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVD 2338
            CP G+ L      C D DECA G + C      C N +GT+ C CP G+    DG  C D
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAG-NPCSHS---CHNAMGTYYCSCPKGLTIAADGRTCQD 5147

Query: 2339 ENECRTKPGICENGR-CVNIIGSYRC--ECNEGFQSSSSGTECLDNRQGLCFAEVLQTIC 2395
             +EC      C  G+ C N IGSYRC   C  GF+ +S G  C D  +           C
Sbjct: 5148 IDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINE-----------C 5196

Query: 2396 QMASSSR----NLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR--- 2448
            Q +S       N +    C C+                           PGY   GR   
Sbjct: 5197 QESSPCHQRCFNAIGSFHCGCE---------------------------PGYQLKGRKCM 5229

Query: 2449 DIDECKVMPNLCTNGQ-CINTMGSFRCF--CKVGYTTDISGTSCIDLDECSQSPKPCNY- 2504
            D++EC+   N+C   Q C NT G ++C   C  G T   +GT CID+DEC      C Y 
Sbjct: 5230 DVNECR--QNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGT-CIDIDECKDGTHQCRYN 5286

Query: 2505 -ICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPG-- 2561
             IC+NT GSY+C CPRGY  Q  G+ C D++EC+     C   C NT G F C CPPG  
Sbjct: 5287 QICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQH 5346

Query: 2562 --------------------FTQHHTACIDNNECGSQPS--------LCGAKGICQNTPG 2593
                                ++ ++ A         QP         L  +    +N+  
Sbjct: 5347 LLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRT 5406

Query: 2594 SFSCE-------CQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQH 2646
            S S         C  G   +A+   C D+DEC+    CQH C+N  G Y+C CP GY   
Sbjct: 5407 SLSRTRRTIRKTCPEGS--EASHDTCVDIDECENTDACQHECKNTFGSYQCICPPGYQLT 5464

Query: 2647 YQWNQCVDENECSNPNA-CG-SASCYNTLGSYKC---ACPSGFSFDQFSSAC 2693
            +    C D +EC   N  CG +  C+N  GSY+C    CP  +  D  S  C
Sbjct: 5465 HNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFC 5516



 Score =  210 bits (534), Expect = 2e-53
 Identities = 152/495 (30%), Positives = 218/495 (44%), Gaps = 94/495 (18%)

Query: 974  SKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAW 1033
            SKG    +CP G TLD  G  C D           EDEC                   A 
Sbjct: 5084 SKGDRSNQCPSGFTLDSVGPFCAD-----------EDEC-------------------AA 5113

Query: 1034 GTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGK-CRNT 1092
            G  C          Y   CP+G   A  G         +DI+EC      C  G+ C NT
Sbjct: 5114 GNPCSHSCHNAMGTYYCSCPKGLTIAADGRTC------QDIDECALGRHTCHAGQDCDNT 5167

Query: 1093 IGSFKC--RCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGF 1150
            IGS++C  RC SGF    +  +C DI+EC+ S   C    C N  GSF C C  GY+   
Sbjct: 5168 IGSYRCVVRCGSGFRRTSDGLSCQDINECQESSP-CHQR-CFNAIGSFHCGCEPGYQ--- 5222

Query: 1151 MMMKNCMDIDECERNPLLCRGGT-CVNTEGSFQCD--CPLGHELSPSREDCVDINECSLS 1207
            +  + CMD++EC +N  +CR    C NT G ++C   CP G   + +   C+DI+EC   
Sbjct: 5223 LKGRKCMDVNECRQN--VCRPDQHCKNTRGGYKCIDLCPNGMTKAENGT-CIDIDECKDG 5279

Query: 1208 DNLCR-NGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYEC 1266
             + CR N  C N  G+Y+C C  GY++    + C DI+EC  +   C  QC+N+ GS++C
Sbjct: 5280 THQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKC 5339

Query: 1267 SCSEGYALMPDGRSCADIDECENNPDICDG-------------------GQCTNIPGEY- 1306
             C  G  L+ DG+SCA ++   N                           Q +++   Y 
Sbjct: 5340 ICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYS 5399

Query: 1307 ----------------RCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFIC 1350
                            R  C +G  AS D  TC+D++EC+ N++ C   EC+NT GS+ C
Sbjct: 5400 EYRNSRTSLSRTRRTIRKTCPEGSEASHD--TCVDIDECE-NTDACQH-ECKNTFGSYQC 5455

Query: 1351 HCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKC---SCREGWIGNGIKCI 1407
             C  GY +      C D+DEC     +C  +  C N+ GS++C    C   +  + +   
Sbjct: 5456 ICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGF 5515

Query: 1408 DLDECSNGTHQCSIN 1422
             L  C     +C+++
Sbjct: 5516 CLKNCPPNDLECALS 5530



 Score =  207 bits (528), Expect = 9e-53
 Identities = 152/484 (31%), Positives = 209/484 (43%), Gaps = 100/484 (20%)

Query: 1919 CHNGFKASQDQTMCMDVDECER-HPCGNGTCKNTVGSYNCLCYPGFELTHNN-DCLDIDE 1976
            C +GF        C D DEC   +PC + +C N +G+Y C C  G  +  +   C DIDE
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAGNPCSH-SCHNAMGTYYCSCPKGLTIAADGRTCQDIDE 5150

Query: 1977 CSSFFGQVCRNGR-CFNEIGSFKCL--CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQ 2033
            C+      C  G+ C N IGS++C+  C  G+  T DG +C D NEC     S     C 
Sbjct: 5151 CA-LGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQE--SSPCHQRCF 5207

Query: 2034 NLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGS-CTNTPGGFQC--LCPPGFVLS 2090
            N  GSF C C PGY++K   C+D+NEC +  N+C     C NT GG++C  LCP G   +
Sbjct: 5208 NAIGSFHCGCEPGYQLKGRKCMDVNECRQ--NVCRPDQHCKNTRGGYKCIDLCPNGMTKA 5265

Query: 2091 DNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKA--KCCCSK-MPGEGWGDPCELCPKDD 2147
            +NG  C D  +    T+    +C   +    T+   +C C +    +G G PC       
Sbjct: 5266 ENGT-CIDIDECKDGTH----QCRYNQICENTRGSYRCVCPRGYRSQGVGRPCM------ 5314

Query: 2148 EVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYT 2207
                                   D+NEC + P  C++ QC NT GSF+C CP G +L   
Sbjct: 5315 -----------------------DINECEQVPKPCAH-QCSNTPGSFKCICPPGQHLLGD 5350

Query: 2208 GVRCVDTDEC------------SIGNPCGNG-------------------------TCTN 2230
            G  C   +              +  +P  N                          + + 
Sbjct: 5351 GKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSR 5410

Query: 2231 VIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQK 2290
               +    C EG E      C DI+EC +N   C   C NTFGSY+C CP GY L  + K
Sbjct: 5411 TRRTIRKTCPEGSEASHD-TCVDIDEC-ENTDACQHECKNTFGSYQCICPPGYQLTHNGK 5468

Query: 2291 MCKDLDECAEGLHDCESRGMMCKNLIGTFMCI---CPPGMARRPDGEGCV-----DENEC 2342
             C+D+DEC E    C     MC N+ G++ CI   CPP   R P    C+     ++ EC
Sbjct: 5469 TCQDIDECLEQNVHC-GPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLEC 5527

Query: 2343 RTKP 2346
               P
Sbjct: 5528 ALSP 5531



 Score =  205 bits (522), Expect = 5e-52
 Identities = 146/472 (30%), Positives = 203/472 (43%), Gaps = 98/472 (20%)

Query: 2155 CPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDT 2214
            CP G  T+ S+     D +EC      CS+  C N  G++ C CP G  +   G  C D 
Sbjct: 5092 CPSGF-TLDSVGPFCADEDECAAG-NPCSHS-CHNAMGTYYCSCPKGLTIAADGRTCQDI 5148

Query: 2215 DECSIG-NPCGNGT-CTNVIGSFEC--NCNEGFE-PGPMMNCEDINECAQNPLLCAFRCM 2269
            DEC++G + C  G  C N IGS+ C   C  GF      ++C+DINEC Q    C  RC 
Sbjct: 5149 DECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINEC-QESSPCHQRCF 5207

Query: 2270 NTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI--CPPGM 2327
            N  GS+ C C  GY L+   + C D++EC + +   +     CKN  G + CI  CP GM
Sbjct: 5208 NAIGSFHCGCEPGYQLKG--RKCMDVNECRQNVCRPDQH---CKNTRGGYKCIDLCPNGM 5262

Query: 2328 ARRPDGEGCVDENECRTKPGICE-NGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLC 2386
             +  +G  C+D +EC+     C  N  C N  GSYRC C  G++S   G  C+D  +   
Sbjct: 5263 TKAENGT-CIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINE--- 5318

Query: 2387 FAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTD 2446
                                    C    +   HQC   P      +K ICP G     D
Sbjct: 5319 ------------------------CEQVPKPCAHQCSNTP----GSFKCICPPGQHLLGD 5350

Query: 2447 GRDIDECKVMPNLCTNGQCIN--------------------------------------- 2467
            G+     + +PN  T     N                                       
Sbjct: 5351 GKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSR 5410

Query: 2468 TMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDG 2527
            T  + R  C  G  ++ S  +C+D+DEC ++   C + CKNT GSYQC CP GY L  +G
Sbjct: 5411 TRRTIRKTCPEG--SEASHDTCVDIDEC-ENTDACQHECKNTFGSYQCICPPGYQLTHNG 5467

Query: 2528 KTCKDLDECQTKQHNC--QFLCVNTLGGFTC---KCPPGFTQHHTA--CIDN 2572
            KTC+D+DEC  +  +C    +C N  G + C    CPP + +   +  C+ N
Sbjct: 5468 KTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKN 5519



 Score =  202 bits (513), Expect = 5e-51
 Identities = 126/355 (35%), Positives = 170/355 (47%), Gaps = 34/355 (9%)

Query: 2476 CKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDE 2535
            C  G+T D  G  C D DEC+    PC++ C N  G+Y CSCP+G  +  DG+TC+D+DE
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAG-NPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDE 5150

Query: 2536 CQTKQHNCQFL--CVNTLGGFTC--KCPPGF--TQHHTACIDNNECGSQPSLCGAKGICQ 2589
            C   +H C     C NT+G + C  +C  GF  T    +C D NEC  + S C  +  C 
Sbjct: 5151 CALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINEC-QESSPCHQR--CF 5207

Query: 2590 NTPGSFSCECQRGFSLDATGLNCEDVDECDGNH-RCQHGCQNILGGYRCG--CPQGYIQH 2646
            N  GSF C C+ G+ L   G  C DV+EC  N  R    C+N  GGY+C   CP G  + 
Sbjct: 5208 NAIGSFHCGCEPGYQLK--GRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKA 5265

Query: 2647 YQWNQCVDENECSN-PNACG-SASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKN 2704
                 C+D +EC +  + C  +  C NT GSY+C CP G+        C D+NEC     
Sbjct: 5266 EN-GTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPK 5324

Query: 2705 PCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGM------GFNKGQYLSLDTEVDEENALS 2758
            PC + CSNT G + C CPPG + +G G   +G+      G     Y +L       N   
Sbjct: 5325 PCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSY-NLARFSPVRNNYQ 5383

Query: 2759 PEACYECKINGYSKKD---------SRQKRSIHEPDPTAVEQISLESVDMDSPVN 2804
            P+  Y    + YS            SR +R+I +  P   E      VD+D   N
Sbjct: 5384 PQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDECEN 5438



 Score =  200 bits (509), Expect = 1e-50
 Identities = 147/493 (29%), Positives = 200/493 (40%), Gaps = 105/493 (21%)

Query: 2323 CPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNR 2382
            CP G      G  C DE+EC      C +  C N +G+Y C C +G   ++ G  C D  
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAG-NPCSHS-CHNAMGTYYCSCPKGLTIAADGRTCQDID 5149

Query: 2383 QGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPG 2442
            +      + +  C       N +    C    G G+                        
Sbjct: 5150 E----CALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRR---------------------- 5183

Query: 2443 YTTDG---RDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSP 2499
             T+DG   +DI+EC+   +   + +C N +GSF C C+ GY   + G  C+D++EC Q+ 
Sbjct: 5184 -TSDGLSCQDINECQ--ESSPCHQRCFNAIGSFHCGCEPGY--QLKGRKCMDVNECRQNV 5238

Query: 2500 KPCNYICKNTEGSYQCS--CPRGYVLQEDGKTCKDLDECQTKQHNCQF--LCVNTLGGFT 2555
               +  CKNT G Y+C   CP G    E+G TC D+DEC+   H C++  +C NT G + 
Sbjct: 5239 CRPDQHCKNTRGGYKCIDLCPNGMTKAENG-TCIDIDECKDGTHQCRYNQICENTRGSYR 5297

Query: 2556 CKCPPGFTQHHTA--CIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCE 2613
            C CP G+        C+D NEC   P  C  +  C NTPGSF C C  G  L   G +C 
Sbjct: 5298 CVCPRGYRSQGVGRPCMDINECEQVPKPCAHQ--CSNTPGSFKCICPPGQHLLGDGKSCA 5355

Query: 2614 DVDECDGNHRCQHGCQNIL-------------------------GGYRCG---------- 2638
             ++    N+  Q+   N+                            YR            
Sbjct: 5356 GLERLP-NYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRT 5414

Query: 2639 ----CPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACH 2694
                CP+G       + CVD +EC N +AC    C NT GSY+C CP G+        C 
Sbjct: 5415 IRKTCPEG--SEASHDTCVDIDECENTDAC-QHECKNTFGSYQCICPPGYQLTHNGKTCQ 5471

Query: 2695 DVNECSSSKNPC--NYGCSNTEGGYLC---GCPPGYYR-VGQGHCVSGMGFNKGQYLSLD 2748
            D++EC      C  N  C N  G Y C    CPP Y R    G C+     N        
Sbjct: 5472 DIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPN-------- 5523

Query: 2749 TEVDEENALSPEA 2761
               D E ALSP A
Sbjct: 5524 ---DLECALSPYA 5533



 Score =  199 bits (506), Expect = 3e-50
 Identities = 145/442 (32%), Positives = 190/442 (42%), Gaps = 76/442 (17%)

Query: 1344 TKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW--IG 1401
            +KG     C  G+++      C D DEC  G  N   H SC N  G++ CSC +G     
Sbjct: 5084 SKGDRSNQCPSGFTLDSVGPFCADEDECAAG--NPCSH-SCHNAMGTYYCSCPKGLTIAA 5140

Query: 1402 NGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCA--CSEGF--TGDGFTCSDVDECAENI 1457
            +G  C D+DEC+ G H C     C NT GSYRC   C  GF  T DG +C D++EC E+ 
Sbjct: 5141 DGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQES- 5199

Query: 1458 NLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNIC---------------- 1501
            + C   +C N  G++ C CE G+      R C D++EC  QN+C                
Sbjct: 5200 SPCHQ-RCFNAIGSFHCGCEPGY--QLKGRKCMDVNECR-QNVCRPDQHCKNTRGGYKCI 5255

Query: 1502 ----------VFGT-------------------CNNLPGMFHCICDDGYELDRTGGNCTD 1532
                        GT                   C N  G + C+C  GY     G  C D
Sbjct: 5256 DLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMD 5315

Query: 1533 IDECAD-PINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVD----NRVGNCYLKFGPRG 1587
            I+EC   P  C +  C NTPG ++C CPP   L   G  C         G  Y  +    
Sbjct: 5316 INECEQVPKPCAH-QCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLAR 5374

Query: 1588 DGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITII 1647
               +  N +      + S   S    + N   +      T   T CP  EG   +  T +
Sbjct: 5375 FSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKT-CP--EGSEASHDTCV 5431

Query: 1648 LEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPG- 1706
              DIDEC+     CQ   C NTFGS+QC CP GY L+ + + C+DIDEC      CGP  
Sbjct: 5432 --DIDECENTDA-CQ-HECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNR 5487

Query: 1707 TCYNTLGNYTCI---CPPEYMQ 1725
             C+N  G+Y CI   CPP Y +
Sbjct: 5488 MCFNMRGSYQCIDTPCPPNYQR 5509



 Score =  189 bits (479), Expect = 4e-47
 Identities = 133/465 (28%), Positives = 206/465 (44%), Gaps = 97/465 (20%)

Query: 1633 CPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICED 1692
            CP G  F  + +     D DEC    G     +C N  G++ C CP+G  ++ D R C+D
Sbjct: 5092 CPSG--FTLDSVGPFCADEDECAA--GNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQD 5147

Query: 1693 IDECFAHPGVCGPGT-CYNTLGNYTCI--CPPEYMQVNGGHNCMDMRKSFCYRSYNGTTC 1749
            IDEC      C  G  C NT+G+Y C+  C   + + + G +C D+ +           C
Sbjct: 5148 IDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINE-----------C 5196

Query: 1750 ENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDI 1809
            +   P +   + C   +N   +++  CEP                    + +   K +D+
Sbjct: 5197 QESSPCH---QRC---FNAIGSFHCGCEP-------------------GYQLKGRKCMDV 5231

Query: 1810 DECKEIPGICA-NGVCINQIGSFRCE--CPTGFSYNDLLLVCEDIDECSNGDNLCQRNAD 1866
            +EC++   +C  +  C N  G ++C   CP G +  +    C DIDEC +G + C+ N  
Sbjct: 5232 NECRQ--NVCRPDQHCKNTRGGYKCIDLCPNGMTKAENG-TCIDIDECKDGTHQCRYNQI 5288

Query: 1867 CINSPGSYRCECAAGFKLSPNGA-CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKA 1925
            C N+ GSYRC C  G++    G  C+D NEC ++P  C+H  C +  GS++CIC  G   
Sbjct: 5289 CENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQ-CSNTPGSFKCICPPGQHL 5347

Query: 1926 SQDQTMCMDVDECERH-------------PCGNG-------------------------T 1947
              D   C  ++    +             P  N                          +
Sbjct: 5348 LGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTS 5407

Query: 1948 CKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYEL 2007
               T  +    C  G E +H+  C+DIDEC +     C++  C N  GS++C+C  GY+L
Sbjct: 5408 LSRTRRTIRKTCPEGSEASHDT-CVDIDECEN--TDACQH-ECKNTFGSYQCICPPGYQL 5463

Query: 2008 TPDGKNCIDTNECVALPGSCSPG-TCQNLEGSFRCI---CPPGYE 2048
            T +GK C D +EC+     C P   C N+ GS++CI   CPP Y+
Sbjct: 5464 THNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQ 5508



 Score =  187 bits (474), Expect = 2e-46
 Identities = 149/475 (31%), Positives = 200/475 (42%), Gaps = 68/475 (14%)

Query: 1436 CSEGFTGD--GFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDID 1493
            C  GFT D  G  C+D DECA   N C +  C N  G Y C C  G T A+D R+CQDID
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAG-NPCSHS-CHNAMGTYYCSCPKGLTIAADGRTCQDID 5149

Query: 1494 ECSF-QNICVFGT-CNNLPGMFHCI--CDDGYELDRTGGNCTDIDECADPINCVNGLCVN 1549
            EC+  ++ C  G  C+N  G + C+  C  G+     G +C DI+EC +   C +  C N
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPC-HQRCFN 5208

Query: 1550 TPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCS 1609
              G + C C P +QL   G  C+D  V  C                       R + C  
Sbjct: 5209 AIGSFHCGCEPGYQLK--GRKCMD--VNEC-----------------------RQNVC-- 5239

Query: 1610 LGKAWGNPCETCPPVNST-EYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGN-CI 1667
                   P + C       +   LCP G     N   I   DIDEC++    C+    C 
Sbjct: 5240 ------RPDQHCKNTRGGYKCIDLCPNGMTKAENGTCI---DIDECKDGTHQCRYNQICE 5290

Query: 1668 NTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVN 1727
            NT GS++C CP+GY      R C DI+EC   P  C    C NT G++ CICPP    + 
Sbjct: 5291 NTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAH-QCSNTPGSFKCICPPGQHLLG 5349

Query: 1728 GGHNCMDMRK----SFCYRSYN---GTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCP 1780
             G +C  + +       Y SYN    +   N        R     Y+    +        
Sbjct: 5350 DGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRN----SR 5405

Query: 1781 TPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFS 1840
            T  +   +TI    P  +   H    VDIDEC+          C N  GS++C CP G+ 
Sbjct: 5406 TSLSRTRRTIRKTCPEGSEASH-DTCVDIDECENTD--ACQHECKNTFGSYQCICPPGYQ 5462

Query: 1841 YNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRC---ECAAGFKLSP-NGACV 1891
                   C+DIDEC   +  C  N  C N  GSY+C    C   ++  P +G C+
Sbjct: 5463 LTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCL 5517



 Score =  177 bits (448), Expect = 2e-43
 Identities = 126/418 (30%), Positives = 174/418 (41%), Gaps = 81/418 (19%)

Query: 520  ECNMGYKQDANGD-CIDVDECTS-NPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDID 577
            +C  G+  D+ G  C D DEC + NPC++  C N  G+YYC C  G       + C DID
Sbjct: 5091 QCPSGFTLDSVGPFCADEDECAAGNPCSHS-CHNAMGTYYCSCPKGLTIAADGRTCQDID 5149

Query: 578  ECIQNGVLCKNGR-CVNTDGSFQCI--CNAGFELTTDGKNCVDHDECTTTNMCLNGMCIN 634
            EC      C  G+ C NT GS++C+  C +GF  T+DG +C D +EC  ++ C +  C N
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPC-HQRCFN 5208

Query: 635  EDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCD--CPPGLAVGM 692
              GSF C C+PG+ L   GR C DV+EC+      + HC N+ G ++C   CP G+    
Sbjct: 5209 AIGSFHCGCEPGYQL--KGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAE 5266

Query: 693  DGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANP--DYGFGEPCQPCPAKNSA 750
            +G  C+D      C  G  +    +          C C       G G PC         
Sbjct: 5267 NG-TCIDI---DECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCM-------- 5314

Query: 751  EFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCID 810
                             DINEC   P  CA+  C N  GS++C C  G      G++C  
Sbjct: 5315 -----------------DINECEQVPKPCAHQ-CSNTPGSFKCICPPGQHLLGDGKSCAG 5356

Query: 811  IDEC-----------------------------LVNRLLCDNGLCRNTPGSYSCT----- 836
            ++                                 + L       RN+  S S T     
Sbjct: 5357 LERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIR 5416

Query: 837  --CPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICID 892
              CP G       +TC DI+ECE+       C+N  GS+ C C PG +L+  G  C D
Sbjct: 5417 KTCPEGS--EASHDTCVDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQD 5472



 Score =  174 bits (442), Expect = 9e-43
 Identities = 137/473 (28%), Positives = 201/473 (42%), Gaps = 93/473 (19%)

Query: 923  TLGAAWGSPCERCELDTACPRGLARIK-GVTCEDVNECEVFPGVCPNGRCVNSKGSFHCE 981
            TLG    +   + +    CP G      G  C D +EC    G   +  C N+ G+++C 
Sbjct: 5074 TLGFKIHASISKGDRSNQCPSGFTLDSVGPFCADEDECAA--GNPCSHSCHNAMGTYYCS 5131

Query: 982  CPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECP 1041
            CP+GLT+   GR C DI           DEC     G+    A         G +C+   
Sbjct: 5132 CPKGLTIAADGRTCQDI-----------DEC---ALGRHTCHA---------GQDCDNT- 5167

Query: 1042 KPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCN 1101
                  Y  +   G+GF    D L+     +DINEC+       + +C N IGSF C C 
Sbjct: 5168 ---IGSYRCVVRCGSGFRRTSDGLS----CQDINECQE--SSPCHQRCFNAIGSFHCGCE 5218

Query: 1102 SGFALDMEERNCTDIDECRISPDLCGSGI-CVNTPGSFECECFEGYESGFMMMKN--CMD 1158
             G+ L  + R C D++ECR   ++C     C NT G ++C   +   +G    +N  C+D
Sbjct: 5219 PGYQL--KGRKCMDVNECR--QNVCRPDQHCKNTRGGYKC--IDLCPNGMTKAENGTCID 5272

Query: 1159 IDECERNPLLCR-GGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCV 1217
            IDEC+     CR    C NT GS++C CP G+        C+DINEC      C + +C 
Sbjct: 5273 IDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAH-QCS 5331

Query: 1218 NMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD----------------------- 1254
            N  G+++C C PG     D + C  ++   + N G                         
Sbjct: 5332 NTPGSFKCICPPGQHLLGDGKSCAGLER--LPNYGTQYSSYNLARFSPVRNNYQPQQHYR 5389

Query: 1255 ----------------TQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQ 1298
                            T  + +  +   +C EG     D  +C DIDECEN  D C   +
Sbjct: 5390 QYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHD--TCVDIDECENT-DACQH-E 5445

Query: 1299 CTNIPGEYRCLCYDGFMASMDMKTCIDVNEC-DLNSNICMFGECENTKGSFIC 1350
            C N  G Y+C+C  G+  + + KTC D++EC + N +      C N +GS+ C
Sbjct: 5446 CKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQC 5498



 Score =  169 bits (429), Expect = 3e-41
 Identities = 147/491 (29%), Positives = 191/491 (38%), Gaps = 128/491 (26%)

Query: 2162 VPSLH--DTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSI 2219
            V +LH      D N+  E+ G   +      D S   +CP G+ LD  G  C D DEC+ 
Sbjct: 5056 VETLHASSVESDYNQIEETLGFKIHASISKGDRSN--QCPSGFTLDSVGPFCADEDECAA 5113

Query: 2220 GNPCGNGTCTNVIGSFECNCNEGFE-PGPMMNCEDINECAQNPLLC--AFRCMNTFGSYE 2276
            GNPC + +C N +G++ C+C +G         C+DI+ECA     C     C NT GSY 
Sbjct: 5114 GNPCSH-SCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYR 5172

Query: 2277 CT--CPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGE 2334
            C   C  G+    D   C+D++EC E    C  R   C N IG+F C C PG   +  G 
Sbjct: 5173 CVVRCGSGFRRTSDGLSCQDINECQES-SPCHQR---CFNAIGSFHCGCEPGYQLK--GR 5226

Query: 2335 GCVDENECR------------TKPG-----ICENGR------------------------ 2353
             C+D NECR            T+ G     +C NG                         
Sbjct: 5227 KCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYN 5286

Query: 2354 --CVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECC 2411
              C N  GSYRC C  G++S   G  C+D        E  Q     A    N     +C 
Sbjct: 5287 QICENTRGSYRCVCPRGYRSQGVGRPCMD------INECEQVPKPCAHQCSNTPGSFKCI 5340

Query: 2412 CDGGR---GWGHQC---ELCPLPGT-----------------------AQY--------- 2433
            C  G+   G G  C   E  P  GT                        QY         
Sbjct: 5341 CPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSE 5400

Query: 2434 ---------------KKICPHGPGYTTDG-RDIDECKVMPNLCTNGQCINTMGSFRCFCK 2477
                           +K CP G   + D   DIDEC+   + C + +C NT GS++C C 
Sbjct: 5401 YRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDECE-NTDACQH-ECKNTFGSYQCICP 5458

Query: 2478 VGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQC---SCPRGYVLQEDGKTCKD 2532
             GY    +G +C D+DEC +    C  N +C N  GSYQC    CP  Y  Q D  +   
Sbjct: 5459 PGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNY--QRDPVSGFC 5516

Query: 2533 LDECQTKQHNC 2543
            L  C      C
Sbjct: 5517 LKNCPPNDLEC 5527



 Score =  164 bits (415), Expect = 1e-39
 Identities = 151/521 (28%), Positives = 212/521 (40%), Gaps = 95/521 (18%)

Query: 672  HCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCA 731
            H   S+G     CP G  +   G  C D                         + EC   
Sbjct: 5080 HASISKGDRSNQCPSGFTLDSVGPFCAD-------------------------EDECAA- 5113

Query: 732  NPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGR---DINECALDPDIC-ANGICENL 787
                  G PC          ++  C  G+ I  DGR   DI+ECAL    C A   C+N 
Sbjct: 5114 ------GNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNT 5167

Query: 788  RGSYRC--NCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 845
             GSYRC   C SG+   + G +C DI+EC  +     +  C N  GS+ C C PGY  + 
Sbjct: 5168 IGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPC--HQRCFNAIGSFHCGCEPGY--QL 5223

Query: 846  ETETCEDINECESNPC-VNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQD 904
            +   C D+NEC  N C  +  C+N  G + C       L   G+   ++  GTC   I  
Sbjct: 5224 KGRKCMDVNECRQNVCRPDQHCKNTRGGYKC-----IDLCPNGMTKAEN--GTC---IDI 5273

Query: 905  SRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGV--TCEDVNECEVF 962
              C+   +       C  T G+       RC     CPRG  R +GV   C D+NECE  
Sbjct: 5274 DECKDGTHQCRYNQICENTRGS------YRC----VCPRGY-RSQGVGRPCMDINECEQV 5322

Query: 963  PGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDI-RMEQCYLKWDEDEC--IHPVPGK 1019
            P  C + +C N+ GSF C CP G  L G G+ C  + R+     ++         PV   
Sbjct: 5323 PKPCAH-QCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNN 5381

Query: 1020 FRMDACCCAVGAAWGTECE-----ECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDI 1074
            ++           + +  E            +     CP G+  ++   V        DI
Sbjct: 5382 YQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCV--------DI 5433

Query: 1075 NECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCG-SGICVN 1133
            +EC+     C + +C+NT GS++C C  G+ L    + C DIDEC      CG + +C N
Sbjct: 5434 DECEN-TDACQH-ECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFN 5491

Query: 1134 TPGSFEC---ECFEGYE----SGFMMMKNCMDID-ECERNP 1166
              GS++C    C   Y+    SGF  +KNC   D EC  +P
Sbjct: 5492 MRGSYQCIDTPCPPNYQRDPVSGF-CLKNCPPNDLECALSP 5531



 Score =  145 bits (366), Expect = 6e-34
 Identities = 113/380 (29%), Positives = 159/380 (41%), Gaps = 66/380 (17%)

Query: 509  RCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCT-NGDCVNTPGSYYC--KCHAGFQ 565
            RC   + S+ C C  GY+      C+DV+EC  N C  +  C NT G Y C   C  G  
Sbjct: 5205 RCFNAIGSFHCGCEPGYQLKGR-KCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMT 5263

Query: 566  RTPTKQACIDIDECIQNGVLCK-NGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTT 624
            +      CIDIDEC      C+ N  C NT GS++C+C  G+     G+ C+D +EC   
Sbjct: 5264 KAENG-TCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQV 5322

Query: 625  NMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDC 684
                   C N  GSFKCIC PG  L  +G+ C  ++     G   + + +      R + 
Sbjct: 5323 PKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNY 5382

Query: 685  PPGLAVGMDGRVCVDTHMR--STCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQ 742
             P              H R  S  Y    +    R    +++++               +
Sbjct: 5383 QP------------QQHYRQYSHLYSSYSE---YRNSRTSLSRTRRTIR----------K 5417

Query: 743  PCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPD 802
             CP  + A  H  C           DI+EC  + D C +  C+N  GSY+C C  GY+  
Sbjct: 5418 TCPEGSEAS-HDTCV----------DIDECE-NTDACQHE-CKNTFGSYQCICPPGYQLT 5464

Query: 803  ASGRNCIDIDECLVNRLLC-DNGLCRNTPGSYSC---TCPPGYVFRTETETCEDINECES 858
             +G+ C DIDECL   + C  N +C N  GSY C    CPP Y               + 
Sbjct: 5465 HNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNY---------------QR 5509

Query: 859  NPCVNGACRNNLGSFNCECS 878
            +P V+G C  N    + EC+
Sbjct: 5510 DP-VSGFCLKNCPPNDLECA 5528



 Score =  119 bits (297), Expect = 6e-26
 Identities = 137/510 (26%), Positives = 193/510 (37%), Gaps = 88/510 (17%)

Query: 165  QCQKGY----IGTYC--------GQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYR 212
            QC  G+    +G +C        G P C + C N    +G   C+C  G T      D R
Sbjct: 5091 QCPSGFTLDSVGPFCADEDECAAGNP-CSHSCHNA---MGTYYCSCPKGLT---IAADGR 5143

Query: 213  TGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTG 272
            T     Q  ++   G+ T        C  TIG    + C +       C  GF       
Sbjct: 5144 T----CQDIDECALGRHTCHAGQD--CDNTIG---SYRCVV------RCGSGFRRTSDGL 5188

Query: 273  ACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG 332
            +CQD++ECQ      Q   C N +GSF C C  G++     +KC D++EC     +C   
Sbjct: 5189 SCQDINECQESSPCHQ--RCFNAIGSFHCGCEPGYQLKG--RKCMDVNECR--QNVCRPD 5242

Query: 333  E-CSNTVGSYFCV--CPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCC 389
            + C NT G Y C+  CP G +T  +   CID     C  G    R  Q         +C 
Sbjct: 5243 QHCKNTRGGYKCIDLCPNG-MTKAENGTCID--IDECKDGTHQCRYNQICENTRGSYRCV 5299

Query: 390  CEPG-RCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPGGTGGNG--FAPSG 446
            C  G R  G+G               R CMD      +P     +   T G+     P G
Sbjct: 5300 CPRGYRSQGVG---------------RPCMDINECEQVPKPCAHQCSNTPGSFKCICPPG 5344

Query: 447  N---GNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHAN 503
                G+G    G   +P  G    S  +           P        +      ++  +
Sbjct: 5345 QHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNS 5404

Query: 504  LCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNGDCVNTPGSYYCKCHAG 563
                 R   T+   R  C  G  + ++  C+D+DEC +      +C NT GSY C C  G
Sbjct: 5405 RTSLSRTRRTI---RKTCPEG-SEASHDTCVDIDECENTDACQHECKNTFGSYQCICPPG 5460

Query: 564  FQRTPTKQACIDIDECIQNGVLC-KNGRCVNTDGSFQCI---CNAGFELTTDG----KNC 615
            +Q T   + C DIDEC++  V C  N  C N  GS+QCI   C   ++         KNC
Sbjct: 5461 YQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNC 5520

Query: 616  VDHD-ECTTTNMCLN--------GMCINED 636
              +D EC  +   L         G+  N+D
Sbjct: 5521 PPNDLECALSPYALEYKLVSLPFGIATNQD 5550



 Score =  116 bits (291), Expect = 3e-25
 Identities = 57/142 (40%), Positives = 74/142 (52%), Gaps = 5/142 (3%)

Query: 2593 GSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQC 2652
            G  S +C  GF+LD+ G  C D DEC   + C H C N +G Y C CP+G         C
Sbjct: 5086 GDRSNQCPSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTC 5145

Query: 2653 VDENECS-NPNAC-GSASCYNTLGSYKCA--CPSGFSFDQFSSACHDVNECSSSKNPCNY 2708
             D +EC+   + C     C NT+GSY+C   C SGF       +C D+NEC  S +PC+ 
Sbjct: 5146 QDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQES-SPCHQ 5204

Query: 2709 GCSNTEGGYLCGCPPGYYRVGQ 2730
             C N  G + CGC PGY   G+
Sbjct: 5205 RCFNAIGSFHCGCEPGYQLKGR 5226



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 80/277 (28%), Positives = 105/277 (37%), Gaps = 61/277 (22%)

Query: 107  GNQCIVPICRNSCGDGFCSRPN---------MC-----------TCSSGQ-ISSTCGSKS 145
            GN C    C N+ G  +CS P           C           TC +GQ   +T GS  
Sbjct: 5114 GNPCSHS-CHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGS-- 5170

Query: 146  IQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGP 205
              +C VRC +G     D   CQ              N CQ    C    RC    G    
Sbjct: 5171 -YRCVVRCGSGFRRTSDGLSCQD------------INECQESSPC--HQRCFNAIGSFHC 5215

Query: 206  QCERDYRTGPCFTQVNNQMCQ--GQLTGIVCTKTLCCATIGRAWGHPC-EMCPAQPQPCR 262
             CE  Y       Q+  + C    +    VC     C       G+ C ++CP       
Sbjct: 5216 GCEPGY-------QLKGRKCMDVNECRQNVCRPDQHCKNT--RGGYKCIDLCP------- 5259

Query: 263  RGFIPNIRTGACQDVDECQAIPGICQGGN-CINTVGSFECRCPAGHKQSETTQKCEDIDE 321
               +     G C D+DEC+     C+    C NT GS+ C CP G++     + C DI+E
Sbjct: 5260 -NGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINE 5318

Query: 322  CSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRC 358
            C  +P  C   +CSNT GS+ C+CP G     DG  C
Sbjct: 5319 CEQVPKPC-AHQCSNTPGSFKCICPPGQHLLGDGKSC 5354



 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 87/316 (27%), Positives = 118/316 (37%), Gaps = 65/316 (20%)

Query: 108  NQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQ 167
            NQC      +S G  FC+  + C   +    S   +     CS  C  G T A D   CQ
Sbjct: 5090 NQCPSGFTLDSVGP-FCADEDECAAGNPCSHSCHNAMGTYYCS--CPKGLTIAADGRTCQ 5146

Query: 168  KGYIGTYCGQPVCENGCQNGGRCIGPNRCA--CVYGFT----GPQCE---RDYRTGPCFT 218
                    G+  C  G Q+    IG  RC   C  GF     G  C+       + PC  
Sbjct: 5147 D-IDECALGRHTCHAG-QDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPC-- 5202

Query: 219  QVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVD 278
               +Q C   +    C                          C  G+   ++   C DV+
Sbjct: 5203 ---HQRCFNAIGSFHCG-------------------------CEPGY--QLKGRKCMDVN 5232

Query: 279  ECQAIPGICQGG-NCINTVGSFEC--RCPAGHKQSETTQKCEDIDECSIIPGICETGE-C 334
            EC+    +C+   +C NT G ++C   CP G  ++E    C DIDEC      C   + C
Sbjct: 5233 ECRQ--NVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGT-CIDIDECKDGTHQCRYNQIC 5289

Query: 335  SNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGR 394
             NT GSY CVCPRGY +   G  C+D     C    V   CA +        +C C PG+
Sbjct: 5290 ENTRGSYRCVCPRGYRSQGVGRPCMD--INECEQ--VPKPCAHQCSNTPGSFKCICPPGQ 5345

Query: 395  --------CWGIGTIP 402
                    C G+  +P
Sbjct: 5346 HLLGDGKSCAGLERLP 5361


>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
          Length = 601

 Score =  231 bits (589), Expect = 8e-60
 Identities = 132/372 (35%), Positives = 192/372 (51%), Gaps = 38/372 (10%)

Query: 1131 CVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCR-GGTCVNTEGSFQCD----C 1185
            C +T     C CF GY+       +C D++EC      CR G +C+NT GSF+C     C
Sbjct: 190  CRDTGDEVVCSCFVGYQL-LSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248

Query: 1186 PLGHELSPSREDCVDINECSLSDNLCR-NGKCVNMIGTYQC----SCNPGYQATPDRQG- 1239
              G+EL+     C DI+EC    + C  +  C N +G+++C     C  G+    D  G 
Sbjct: 249  GTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF--IQDALGN 305

Query: 1240 CTDIDECMIMNGGCDT--QCTNSEGSYEC-----SCSEGYALMPDGRSCADIDECENNPD 1292
            C DI+EC+ ++  C     C N+EGSY C     +C  GY L  +G  C D+DEC    +
Sbjct: 306  CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAE 365

Query: 1293 ICDGG-QCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICH 1351
             C  G +C N PG +RC C  G+      + C+DVNEC          +CENT GS++C 
Sbjct: 366  PCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCS 425

Query: 1352 CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW---IGNGIKCID 1408
            C +G+ +      C D++EC     +      C N+ GS++C CR G+     +G+ C D
Sbjct: 426  CSVGFRLSVDGRSCEDINECS----SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481

Query: 1409 LDECS--NGTHQCSINAQCVNTPGSYRCAC-SEGF--TGDGFTCSDVDECAENINLCE-N 1462
            +DEC+   G H CS   +C+N PGS++C+C S G+    +G  C D+DEC   I+ C  N
Sbjct: 482  IDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539

Query: 1463 GQCLNVPGAYRC 1474
              C N+ G +RC
Sbjct: 540  ETCFNIQGGFRC 551



 Score =  221 bits (562), Expect = 1e-56
 Identities = 143/424 (33%), Positives = 193/424 (45%), Gaps = 68/424 (16%)

Query: 2215 DECSIGNPCGNGTCTNVIGSFECNCNEGFEP-GPMMNCEDINECAQNPLLCAF--RCMNT 2271
            D C  G PC    C +      C+C  G++     ++CED+NEC      C     C+NT
Sbjct: 178  DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 2272 FGSYEC----TCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI----C 2323
             GS+ C    +C  GY L ED   CKD+DEC  G+H+C     +C+N +G+F C     C
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLP-DFICQNTLGSFRCRPKLQC 294

Query: 2324 PPGMARRPDGEGCVDENECRTKPGICENGR-CVNIIGSYRCE-----CNEGFQSSSSGTE 2377
              G  +   G  C+D NEC +    C  G  C+N  GSY C+     C  G+  +  GT 
Sbjct: 295  KSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353

Query: 2378 CLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKIC 2437
            C+D  +                        +E C     G GH+C     PG+ +    C
Sbjct: 354  CVDVDE--------------------CAPPAEPC-----GKGHRC--VNSPGSFR----C 382

Query: 2438 PHGPGYTTDGR-----DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDL 2492
                GY  DG      D++EC+  P      +C NT+GS+ C C VG+   + G SC D+
Sbjct: 383  ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI 442

Query: 2493 DECSQSPKPCNYICKNTEGSYQCSCPRGYVLQE-DGKTCKDLDEC--QTKQHNCQFLCVN 2549
            +ECS S  PC+  C N  GSYQC C RGY L + DG TC+D+DEC   T  H C + C+N
Sbjct: 443  NECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCIN 500

Query: 2550 TLGGFTCKCPPG---FTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSC---ECQRGF 2603
              G F C CP        +   C D +EC +    C     C N  G F C   EC   +
Sbjct: 501  IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560

Query: 2604 SLDA 2607
               A
Sbjct: 561  RRSA 564



 Score =  213 bits (541), Expect = 3e-54
 Identities = 139/393 (35%), Positives = 185/393 (47%), Gaps = 57/393 (14%)

Query: 2363 CECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQC 2422
            C C  G+Q  S G  C D  + +  +      C++  S  N V    C  D   G G++ 
Sbjct: 199  CSCFVGYQLLSDGVSCEDVNECITGSHS----CRLGESCINTVGSFRCQRDSSCGTGYEL 254

Query: 2423 ELCPLPGTAQYKKICPHGPGYTTDG--RDIDECKV-MPNLCTNGQCINTMGSFRCF---- 2475
                                 T D   +DIDEC+  + N   +  C NT+GSFRC     
Sbjct: 255  ---------------------TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQ 293

Query: 2476 CKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQC-----SCPRGYVLQEDGK 2528
            CK G+  D  G +CID++EC     PC   + C NTEGSY C     +C RGY L E+G 
Sbjct: 294  CKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT 352

Query: 2529 TCKDLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG--FTQHHTACIDNNECGSQPS-LCG 2583
             C D+DEC      C     CVN+ G F C+C  G  F      C+D NEC   P  LCG
Sbjct: 353  RCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG 412

Query: 2584 AKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGY 2643
             K  C+NT GS+ C C  GF L   G +CED++EC  +  C   C N+ G Y+C C +GY
Sbjct: 413  HK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP-CSQECANVYGSYQCYCRRGY 469

Query: 2644 -IQHYQWNQCVDENECSNPNACGSAS--CYNTLGSYKCACPS-GFSFDQFSSACHDVNEC 2699
             +       C D +EC+ P      S  C N  GS++C+CPS G+        C D++EC
Sbjct: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 2700 SSSKNPC--NYGCSNTEGGYLC---GCPPGYYR 2727
             +  + C  N  C N +GG+ C    CP  Y R
Sbjct: 530  VTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562



 Score =  211 bits (536), Expect = 1e-53
 Identities = 145/414 (35%), Positives = 202/414 (48%), Gaps = 62/414 (14%)

Query: 1942 PCGNGTCKNTVGSYNCLCYPGFELTHNN-DCLDIDECSSFFGQVCRNGR-CFNEIGSFKC 1999
            PC    C++T     C C+ G++L  +   C D++EC +     CR G  C N +GSF+C
Sbjct: 185  PCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITG-SHSCRLGESCINTVGSFRC 242

Query: 2000 L----CNEGYELTPDGKNCIDTNECVALPGSCSPG-TCQNLEGSFRCI----CPPGY-EV 2049
                 C  GYELT D  +C D +EC +   +C P   CQN  GSFRC     C  G+ + 
Sbjct: 243  QRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD 301

Query: 2050 KSENCIDINECDEDPNICLFG-SCTNTPGGFQCL-----CPPGFVLSDNGRRCFDTRQSF 2103
               NCIDINEC      C  G +C NT G + C      C  G+ L++ G RC D  +  
Sbjct: 302  ALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE-- 359

Query: 2104 CFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVP 2163
                     C+ P       A+ C       G G  C   P     +F+  C  G+    
Sbjct: 360  ---------CAPP-------AEPC-------GKGHRCVNSPG----SFRCECKTGY-YFD 391

Query: 2164 SLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPC 2223
             +     DVNEC   PG     +C NT GS+ C C +G+ L   G  C D +ECS  +PC
Sbjct: 392  GISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPC 450

Query: 2224 GNGTCTNVIGSFECNCNEGFEPGPM--MNCEDINECA--QNPLLCAFRCMNTFGSYECTC 2279
                C NV GS++C C  G++   +  + CEDI+ECA      +C++RC+N  GS++C+C
Sbjct: 451  SQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSC 509

Query: 2280 P-IGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI---CPPGMAR 2329
            P  GY L  + + C+D+DEC  G+H+C S    C N+ G F C+   CP    R
Sbjct: 510  PSSGYRLAPNGRNCQDIDECVTGIHNC-SINETCFNIQGGFRCLAFECPENYRR 562



 Score =  207 bits (528), Expect = 9e-53
 Identities = 177/614 (28%), Positives = 242/614 (39%), Gaps = 122/614 (19%)

Query: 1166 PLLCRGGTC-----VNTEGSFQCDCPLGHELSPSREDC-----VDINECSLSDNLCRNGK 1215
            PLL  GG       V+ +   +  C  GH ++  ++DC      +  EC +    C    
Sbjct: 13   PLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQC---- 68

Query: 1216 CVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNG-GCDTQCTNSEGSYECSCSEGYAL 1274
            C + +    C+         DR        C   +G     + T  +    C C  G A 
Sbjct: 69   CHSQLEELHCATGISLANEQDR--------CATPHGDNASLEATFVKRCCHC-CLLGRAA 119

Query: 1275 MPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYD---------GFMASMDMKTCID 1325
               G+SC           +  G QC  +   +R  C           G +   D    ++
Sbjct: 120  QAQGQSC--------EYSLMVGYQCGQV---FRACCVKSQETGDLDVGGLQETDKIIEVE 168

Query: 1326 VNECD--LNSNICMFG-----ECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNC 1378
              + D  LN   C  G     +C +T    +C C +GY +      C DV+EC  G+H+C
Sbjct: 169  EEQEDPYLNDR-CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227

Query: 1379 DMHASCLNIPGSFKC----SCREGW-IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYR 1433
             +  SC+N  GSF+C    SC  G+ +     C D+DEC +G H C  +  C NT GS+R
Sbjct: 228  RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFR 287

Query: 1434 C----ACSEGFTGDGF-TCSDVDECAENINLCENGQ-CLNVPGAYRCE-----CEMGFTP 1482
            C     C  GF  D    C D++EC      C  G  C+N  G+Y C+     C  G+  
Sbjct: 288  CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL 347

Query: 1483 ASDSRSCQDIDECS-FQNICVFG-TCNNLPGMFHCICDDGYELDRTGGNCTDIDECAD-P 1539
              +   C D+DEC+     C  G  C N PG F C C  GY  D     C D++EC   P
Sbjct: 348  NEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYP 407

Query: 1540 INCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGV 1599
                   C NT G Y C+C   F+L+  G  C D  +  C          S  C+ E   
Sbjct: 408  GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED--INEC---------SSSPCSQECAN 456

Query: 1600 GVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPG 1659
                  C C  G                  Y L         +   +  EDIDEC     
Sbjct: 457  VYGSYQCYCRRG------------------YQL--------SDVDGVTCEDIDEC----A 486

Query: 1660 LCQGGN-----CINTFGSFQCECP-QGYYLSEDTRICEDIDECFAHPGVCGPG-TCYNTL 1712
            L  GG+     CIN  GSFQC CP  GY L+ + R C+DIDEC      C    TC+N  
Sbjct: 487  LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQ 546

Query: 1713 GNYTCI---CPPEY 1723
            G + C+   CP  Y
Sbjct: 547  GGFRCLAFECPENY 560



 Score =  204 bits (518), Expect = 1e-51
 Identities = 136/408 (33%), Positives = 186/408 (45%), Gaps = 61/408 (14%)

Query: 2264 CAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMC-- 2321
            C  +C +T     C+C +GY L  D   C+D++EC  G H C   G  C N +G+F C  
Sbjct: 186  CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRL-GESCINTVGSFRCQR 244

Query: 2322 --ICPPGMARRPDGEGCVDENECRTKPGIC-ENGRCVNIIGSYRC----ECNEGFQSSSS 2374
               C  G     D   C D +EC +    C  +  C N +GS+RC    +C  GF   + 
Sbjct: 245  DSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDAL 303

Query: 2375 GTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYK 2434
            G  C+D  + L     +   C +                     GH C       T Q K
Sbjct: 304  GN-CIDINECLS----ISAPCPI---------------------GHTCINTEGSYTCQ-K 336

Query: 2435 KICPHGPGYTTDGR-----DIDECKVMPNLCTNG-QCINTMGSFRCFCKVGYTTDISGTS 2488
             +   G GY  +       D+DEC      C  G +C+N+ GSFRC CK GY  D     
Sbjct: 337  NVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRM 396

Query: 2489 CIDLDECSQSP-KPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLC 2547
            C+D++EC + P + C + C+NT GSY CSC  G+ L  DG++C+D++EC +    C   C
Sbjct: 397  CVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQEC 454

Query: 2548 VNTLGGFTCKCPPGFTQHHT---ACIDNNECGSQPS--LCGAKGICQNTPGSFSCEC-QR 2601
             N  G + C C  G+         C D +EC       +C  +  C N PGSF C C   
Sbjct: 455  ANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR--CINIPGSFQCSCPSS 512

Query: 2602 GFSLDATGLNCEDVDEC-DGNHRCQ--HGCQNILGGYRC---GCPQGY 2643
            G+ L   G NC+D+DEC  G H C     C NI GG+RC    CP+ Y
Sbjct: 513  GYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560



 Score =  196 bits (497), Expect = 4e-49
 Identities = 124/364 (34%), Positives = 170/364 (46%), Gaps = 48/364 (13%)

Query: 2412 CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYT--TDG---RDIDECKVMPNLCTNGQ-C 2465
            C GG     QC           + +C    GY   +DG    D++EC    + C  G+ C
Sbjct: 180  CRGGGPCKQQCR------DTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESC 233

Query: 2466 INTMGSFRC----FCKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQC---- 2515
            INT+GSFRC     C  GY       SC D+DEC      C  ++IC+NT GS++C    
Sbjct: 234  INTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292

Query: 2516 SCPRGYVLQEDGKTCKDLDECQTKQHNCQF--LCVNTLGGFTCK-----CPPGF--TQHH 2566
             C  G++    G  C D++EC +    C     C+NT G +TC+     C  G+   +  
Sbjct: 293  QCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351

Query: 2567 TACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECD--GNHRC 2624
            T C+D +EC      CG    C N+PGSF CEC+ G+  D     C DV+EC       C
Sbjct: 352  TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411

Query: 2625 QHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGF 2684
             H C+N LG Y C C  G+        C D NECS+ + C S  C N  GSY+C C  G+
Sbjct: 412  GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-SPC-SQECANVYGSYQCYCRRGY 469

Query: 2685 SF-DQFSSACHDVNECS--SSKNPCNYGCSNTEGGYLCGCPPGYYRVGQG--------HC 2733
               D     C D++EC+  +  + C+Y C N  G + C CP   YR+            C
Sbjct: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 2734 VSGM 2737
            V+G+
Sbjct: 530  VTGI 533



 Score =  194 bits (493), Expect = 1e-48
 Identities = 135/401 (33%), Positives = 185/401 (46%), Gaps = 58/401 (14%)

Query: 970  RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAV 1029
            +C ++     C C  G  L   G  C D+           +ECI         ++C   V
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDV-----------NECITGSHSCRLGESCINTV 237

Query: 1030 GAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGK- 1088
            G+     C+     GT                G  LT     KDI+EC++    C     
Sbjct: 238  GSF---RCQRDSSCGT----------------GYELTEDNSCKDIDECESGIHNCLPDFI 278

Query: 1089 CRNTIGSFKCR----CNSGFALDMEERNCTDIDECRISPDLCGSG-ICVNTPGSFECE-- 1141
            C+NT+GSF+CR    C SGF  D    NC DI+EC      C  G  C+NT GS+ C+  
Sbjct: 279  CQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKN 337

Query: 1142 ---CFEGY---ESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEGSFQCDCPLGHELSPS 1194
               C  GY   E G      C+D+DEC      C +G  CVN+ GSF+C+C  G+     
Sbjct: 338  VPNCGRGYHLNEEG----TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI 393

Query: 1195 REDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD 1254
               CVD+NEC          KC N +G+Y CSC+ G++ + D + C DI+EC   +  C 
Sbjct: 394  SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCS 451

Query: 1255 TQCTNSEGSYECSCSEGYALMP-DGRSCADIDEC--ENNPDICDGGQCTNIPGEYRCLC- 1310
             +C N  GSY+C C  GY L   DG +C DIDEC       IC   +C NIPG ++C C 
Sbjct: 452  QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCP 510

Query: 1311 YDGFMASMDMKTCIDVNECDLNSNICMFGE-CENTKGSFIC 1350
              G+  + + + C D++EC    + C   E C N +G F C
Sbjct: 511  SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  194 bits (492), Expect = 1e-48
 Identities = 138/435 (31%), Positives = 197/435 (45%), Gaps = 70/435 (16%)

Query: 1803 TGKAVDIDECKEIPGI---CANG-----VCINQIGSFRCECPTGFSYNDLLLVCEDIDEC 1854
            T K ++++E +E P +   C  G      C +      C C  G+      + CED++EC
Sbjct: 161  TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220

Query: 1855 SNGDNLCQRNADCINSPGSYRCE----CAAGFKLSPNGACVDRNECLE-IPNVCSHGLCV 1909
              G + C+    CIN+ GS+RC+    C  G++L+ + +C D +EC   I N     +C 
Sbjct: 221  ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ 280

Query: 1910 DLQGSYQCI----CHNGFKASQDQT-MCMDVDECER--HPCGNG-TCKNTVGSYNCL--- 1958
            +  GS++C     C +GF   QD    C+D++EC     PC  G TC NT GSY C    
Sbjct: 281  NTLGSFRCRPKLQCKSGF--IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338

Query: 1959 --CYPGFELTHNND-CLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCI 2015
              C  G+ L      C+D+DEC+       +  RC N  GSF+C C  GY      + C+
Sbjct: 339  PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 2016 DTNECVALPGSCSPGTCQNLEGSFRCICPPGY--EVKSENCIDINECDEDPNICLFGSCT 2073
            D NEC   PG      C+N  GS+ C C  G+   V   +C DINEC   P       C 
Sbjct: 399  DVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECA 455

Query: 2074 NTPGGFQCLCPPGFVLSD-NGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMP 2132
            N  G +QC C  G+ LSD +G  C D             +C++P   +    +C    +P
Sbjct: 456  NVYGSYQCYCRRGYQLSDVDGVTCEDI-----------DECALPTGGHICSYRCI--NIP 502

Query: 2133 GEGWGDPCELCPKDDEVAFQDLCP-YGHGTVPSLHDTREDVNECLESPGICS-NGQCINT 2190
            G                +FQ  CP  G+   P+  +  +D++EC+     CS N  C N 
Sbjct: 503  G----------------SFQCSCPSSGYRLAPNGRNC-QDIDECVTGIHNCSINETCFNI 545

Query: 2191 DGSFRC---ECPMGY 2202
             G FRC   ECP  Y
Sbjct: 546  QGGFRCLAFECPENY 560



 Score =  193 bits (490), Expect = 2e-48
 Identities = 137/454 (30%), Positives = 196/454 (43%), Gaps = 70/454 (15%)

Query: 2287 EDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKP 2346
            E+++    L++   G   C+ +   C++     +C C  G     DG  C D NEC T  
Sbjct: 168  EEEQEDPYLNDRCRGGGPCKQQ---CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGS 224

Query: 2347 GICENGR-CVNIIGSYRCE----CNEGFQ-SSSSGTECLDNRQGLCFAEVLQTICQMASS 2400
              C  G  C+N +GS+RC+    C  G++ +  +  + +D  +      +   ICQ    
Sbjct: 225  HSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLG 284

Query: 2401 SRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR----DIDECKVM 2456
            S     K +C                               G+  D      DI+EC  +
Sbjct: 285  SFRCRPKLQC-----------------------------KSGFIQDALGNCIDINECLSI 315

Query: 2457 PNLCTNGQ-CINTMGSFRCF-----CKVGYTTDISGTSCIDLDECSQSPKPCN--YICKN 2508
               C  G  CINT GS+ C      C  GY  +  GT C+D+DEC+   +PC   + C N
Sbjct: 316  SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVN 375

Query: 2509 TEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHN-CQFLCVNTLGGFTCKCPPGF--TQH 2565
            + GS++C C  GY      + C D++ECQ      C   C NTLG + C C  GF  +  
Sbjct: 376  SPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVD 435

Query: 2566 HTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSL-DATGLNCEDVDEC---DGN 2621
              +C D NEC S P  C  +  C N  GS+ C C+RG+ L D  G+ CED+DEC    G 
Sbjct: 436  GRSCEDINECSSSP--CSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGG 491

Query: 2622 HRCQHGCQNILGGYRCGCPQ-GYIQHYQWNQCVDENECSNP--NACGSASCYNTLGSYKC 2678
            H C + C NI G ++C CP  GY        C D +EC     N   + +C+N  G ++C
Sbjct: 492  HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551

Query: 2679 ---ACPSGF---SFDQFSSACHDVNECSSSKNPC 2706
                CP  +   +  Q S          SSK  C
Sbjct: 552  LAFECPENYRRSAATQKSKKGRQNTPAGSSKEDC 585



 Score =  184 bits (467), Expect = 1e-45
 Identities = 130/381 (34%), Positives = 174/381 (45%), Gaps = 67/381 (17%)

Query: 493 QTIDICKHHANLCLNGR-CIPTVSSYRCE----CNMGYKQDANGDCIDVDECTS---NPC 544
           + ++ C   ++ C  G  CI TV S+RC+    C  GY+   +  C D+DEC S   N  
Sbjct: 215 EDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCL 274

Query: 545 TNGDCVNTPGSYYCK----CHAGFQRTPTKQACIDIDECIQNGVLCKNGR-CVNTDGSFQ 599
            +  C NT GS+ C+    C +GF +      CIDI+EC+     C  G  C+NT+GS+ 
Sbjct: 275 PDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYT 333

Query: 600 C-----ICNAGFELTTDGKNCVDHDECT-TTNMCLNG-MCINEDGSFKCICKPGFVLAPN 652
           C      C  G+ L  +G  CVD DEC      C  G  C+N  GSF+C CK G+     
Sbjct: 334 CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI 393

Query: 653 GRYCTDVDECQT-PGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIK 711
            R C DV+ECQ  PG      C N+ GS+ C C  G  + +DGR C D            
Sbjct: 394 SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI----------- 442

Query: 712 KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGIT-VDG---R 767
                         +EC           PC    A     +   C  G  ++ VDG    
Sbjct: 443 --------------NECS--------SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480

Query: 768 DINECALDP--DICANGICENLRGSYRCNC-NSGYEPDASGRNCIDIDECLVNRLLCD-N 823
           DI+ECAL     IC+   C N+ GS++C+C +SGY    +GRNC DIDEC+     C  N
Sbjct: 481 DIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539

Query: 824 GLCRNTPGSYSC---TCPPGY 841
             C N  G + C    CP  Y
Sbjct: 540 ETCFNIQGGFRCLAFECPENY 560



 Score =  170 bits (430), Expect = 2e-41
 Identities = 135/409 (33%), Positives = 177/409 (43%), Gaps = 73/409 (17%)

Query: 537 DECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGR-CVNTD 595
           D C         C +T     C C  G+Q      +C D++ECI     C+ G  C+NT 
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237

Query: 596 GSFQC----ICNAGFELTTDGKNCVDHDECTT-TNMCL-NGMCINEDGSFKCI----CKP 645
           GSF+C     C  G+ELT D  +C D DEC +  + CL + +C N  GSF+C     CK 
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 646 GFVLAPNGRYCTDVDECQTPGI-CMNGH-CINSEGSFRC-----DCPPGLAVGMDGRVCV 698
           GF+    G  C D++EC +    C  GH CIN+EGS+ C     +C  G  +  +G  CV
Sbjct: 297 GFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 699 DTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSS 758
           D                           EC       G G  C   P     E    C +
Sbjct: 356 DV-------------------------DECAPPAEPCGKGHRCVNSPGSFRCE----CKT 386

Query: 759 GV---GITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL 815
           G    GI+    D+NEC   P       CEN  GSY C+C+ G+     GR+C DI+EC 
Sbjct: 387 GYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS 446

Query: 816 VNRLLCDNGLCRNTPGSYSCTCPPGY-VFRTETETCEDINEC---ESNPCVNGACRNNLG 871
            +    +   C N  GSY C C  GY +   +  TCEDI+EC         +  C N  G
Sbjct: 447 SSPCSQE---CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPG 503

Query: 872 SFNCEC-SPGSKLSSTGLICID-----------SLKGTCWLNIQDS-RC 907
           SF C C S G +L+  G  C D           S+  TC+ NIQ   RC
Sbjct: 504 SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCF-NIQGGFRC 551



 Score =  164 bits (416), Expect = 9e-40
 Identities = 135/444 (30%), Positives = 187/444 (42%), Gaps = 91/444 (20%)

Query: 1464 QCLNVPGAYRCECEMGFTPASDSRSCQDIDEC-SFQNICVFG-TCNNLPGMFHC----IC 1517
            QC +      C C +G+   SD  SC+D++EC +  + C  G +C N  G F C     C
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248

Query: 1518 DDGYELDRTGGNCTDIDECADPI-NCV-NGLCVNTPGRYECNCPPDFQLNPTGVGCVDNR 1575
              GYEL     +C DIDEC   I NC+ + +C NT G + C   P  Q      G + + 
Sbjct: 249  GTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCR--PKLQCKS---GFIQDA 302

Query: 1576 VGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPG 1635
            +GNC           +  N  + +     S  C +G        TC  +N+   YT    
Sbjct: 303  LGNC-----------IDINECLSI-----SAPCPIG-------HTC--INTEGSYTCQKN 337

Query: 1636 ----GEGFRPNPITIILEDIDECQELPGLC-QGGNCINTFGSFQCECPQGYYLSEDTRIC 1690
                G G+  N       D+DEC      C +G  C+N+ GSF+CEC  GYY    +R+C
Sbjct: 338  VPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC 397

Query: 1691 EDIDECFAHPG-VCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTC 1749
             D++EC  +PG +CG   C NTLG+Y C C   +     G +C D+ +       + + C
Sbjct: 398  VDVNECQRYPGRLCG-HKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC------SSSPC 450

Query: 1750 ENELPFNVTKRMCCCT--YNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAV 1807
              E         C C   Y +       CE                              
Sbjct: 451  SQECANVYGSYQCYCRRGYQLSDVDGVTCE------------------------------ 480

Query: 1808 DIDECKEIPG--ICANGVCINQIGSFRCECP-TGFSYNDLLLVCEDIDECSNGDNLCQRN 1864
            DIDEC    G  IC+   CIN  GSF+C CP +G+        C+DIDEC  G + C  N
Sbjct: 481  DIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539

Query: 1865 ADCINSPGSYRC---ECAAGFKLS 1885
              C N  G +RC   EC   ++ S
Sbjct: 540  ETCFNIQGGFRCLAFECPENYRRS 563



 Score =  157 bits (398), Expect = 1e-37
 Identities = 177/619 (28%), Positives = 238/619 (38%), Gaps = 131/619 (21%)

Query: 592  VNTDGSFQCICNAGFELTTDGKNC-----VDHDECTTTNMCLNGMCINEDGSFKCICKPG 646
            V+ D   +  C  G  + T  K+C      +  EC    M     C ++     C    G
Sbjct: 27   VDADVLLEACCADGHRMATHQKDCSLPYATESKEC---RMVQEQCCHSQLEELHCAT--G 81

Query: 647  FVLAPNGRYCTDVDECQTPGICMNGHCINSEGSF--RCD--CPPGLAVGMDGRVCVDTHM 702
              LA       + D C TP    +G   + E +F  RC   C  G A    G+ C  + M
Sbjct: 82   ISLA------NEQDRCATP----HGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLM 131

Query: 703  RSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGI 762
                 G + +  CV+                               S E   L   G+  
Sbjct: 132  VGYQCGQVFRACCVK-------------------------------SQETGDLDVGGLQE 160

Query: 763  TVDGRDINECALDP---DICANG-----ICENLRGSYRCNCNSGYEPDASGRNCIDIDEC 814
            T    ++ E   DP   D C  G      C +      C+C  GY+  + G +C D++EC
Sbjct: 161  TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220

Query: 815  LVNRLLCDNG-LCRNTPGSYSC----TCPPGYVFRTETETCEDINECES---NPCVNGAC 866
            +     C  G  C NT GS+ C    +C  GY   TE  +C+DI+ECES   N   +  C
Sbjct: 221  ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDFIC 279

Query: 867  RNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGA 926
            +N LGSF C      KL        D+L G C          ++IN     S  C     
Sbjct: 280  QNTLGSFRCR----PKLQCKSGFIQDAL-GNC----------IDINECLSISAPCPI--- 321

Query: 927  AWGSPCERCELDTACPRGLARI--------KGVTCEDVNECEVFPGVCPNG-RCVNSKGS 977
              G  C   E    C + +           +G  C DV+EC      C  G RCVNS GS
Sbjct: 322  --GHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGS 379

Query: 978  FHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVG---AAWG 1034
            F CEC  G   DG  R+C+D+   Q Y       C H          C C+VG   +  G
Sbjct: 380  FRCECKTGYYFDGISRMCVDVNECQRY---PGRLCGHKCENTLGSYLCSCSVGFRLSVDG 436

Query: 1035 TECE---ECPK-PGTKE-------YETLCPRGAGFANRGDVLTGRPFYKDINECKAFPG- 1082
              CE   EC   P ++E       Y+  C RG   ++   V       +DI+EC    G 
Sbjct: 437  RSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC-----EDIDECALPTGG 491

Query: 1083 -MCTYGKCRNTIGSFKCRC-NSGFALDMEERNCTDIDECRISPDLCG-SGICVNTPGSFE 1139
             +C+Y +C N  GSF+C C +SG+ L    RNC DIDEC      C  +  C N  G F 
Sbjct: 492  HICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFR 550

Query: 1140 C---ECFEGYESGFMMMKN 1155
            C   EC E Y       K+
Sbjct: 551  CLAFECPENYRRSAATQKS 569



 Score =  144 bits (363), Expect = 1e-33
 Identities = 118/398 (29%), Positives = 172/398 (43%), Gaps = 86/398 (21%)

Query: 273 ACQDVDECQAIPGICQ-GGNCINTVGSFECR----CPAGHKQSETTQKCEDIDEC-SIIP 326
           +C+DV+EC      C+ G +CINTVGSF C+    C  G++ +E    C+DIDEC S I 
Sbjct: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIH 271

Query: 327 GICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKM 386
                  C NT+GS+               RC  +    C SG +     Q+  G     
Sbjct: 272 NCLPDFICQNTLGSF---------------RCRPKL--QCKSGFI-----QDALGN---- 305

Query: 387 QCCCEPGRCWGIGTIPEACPVRGS---EEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFA 443
             C +   C  I      CP+  +    E    C   +P                     
Sbjct: 306 --CIDINECLSISA---PCPIGHTCINTEGSYTCQKNVPN-------------------- 340

Query: 444 PSGNGNGYGPGGTGFIPI--------PGGNGF----SPGVGGAGVGAGGQGPIITGLTIL 491
             G G      GT  + +        P G G     SPG        G       G++ +
Sbjct: 341 -CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY---FDGISRM 396

Query: 492 NQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANG-DCIDVDECTSNPCTNGDCV 550
              ++ C+ +       +C  T+ SY C C++G++   +G  C D++EC+S+PC+  +C 
Sbjct: 397 CVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ-ECA 455

Query: 551 NTPGSYYCKCHAGFQRTPTK-QACIDIDECI--QNGVLCKNGRCVNTDGSFQCIC-NAGF 606
           N  GSY C C  G+Q +      C DIDEC     G +C + RC+N  GSFQC C ++G+
Sbjct: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCPSSGY 514

Query: 607 ELTTDGKNCVDHDECTT--TNMCLNGMCINEDGSFKCI 642
            L  +G+NC D DEC T   N  +N  C N  G F+C+
Sbjct: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552



 Score = 99.0 bits (245), Expect = 6e-20
 Identities = 99/327 (30%), Positives = 134/327 (40%), Gaps = 51/327 (15%)

Query: 97  CCPGWKTLPGG------NQCIV--------PICRNSCGDGFCSRPNMCTCSSGQISSTCG 142
           C  G++ L  G      N+CI           C N+ G   C R + C  +  +++    
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG-TGYELTEDNS 259

Query: 143 SKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNG------GRCIGPNRC 196
            K I +C     N   C  D   CQ   +G++  +P  +  C++G      G CI  N C
Sbjct: 260 CKDIDECESGIHN---CLPDFI-CQNT-LGSFRCRPKLQ--CKSGFIQDALGNCIDINEC 312

Query: 197 A-----CVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLT--GIVCTKTLCCATIGRAWG- 248
                 C  G T    E  Y    C   V N      L   G  C     CA      G 
Sbjct: 313 LSISAPCPIGHTCINTEGSYT---CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGK 369

Query: 249 -HPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAG 306
            H C   P   +  C+ G+  +  +  C DV+ECQ  PG   G  C NT+GS+ C C  G
Sbjct: 370 GHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVG 429

Query: 307 HKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGY-VTSTDGSRC--IDQRT 363
            + S   + CEDI+ECS  P  C   EC+N  GSY C C RGY ++  DG  C  ID+  
Sbjct: 430 FRLSVDGRSCEDINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486

Query: 364 GMCFSGLVNGRCAQELPGRMTKMQCCC 390
                 + + RC   +PG     QC C
Sbjct: 487 LPTGGHICSYRCI-NIPG---SFQCSC 509



 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 81/299 (27%), Positives = 113/299 (37%), Gaps = 66/299 (22%)

Query: 152 RCMNGGTCADDHCQCQKGYIGTYC----GQPVCENG--CQNGGRCI-GPNRC----ACVY 200
           RC  GG C     QC+       C    G  +  +G  C++   CI G + C    +C+ 
Sbjct: 179 RCRGGGPCKQ---QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235

Query: 201 GFTGPQCERDYRTGP---------------CFTQVNNQM----CQGQLTGIVCTKTLCCA 241
                +C+RD   G                C + ++N +    CQ  L    C   L C 
Sbjct: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 242 T--IGRAWGH------------PCEM------------CPAQPQPCRRGFIPNIRTGACQ 275
           +  I  A G+            PC +            C      C RG+  N     C 
Sbjct: 296 SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 276 DVDECQAIPGIC-QGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGEC 334
           DVDEC      C +G  C+N+ GSF C C  G+     ++ C D++EC   PG     +C
Sbjct: 356 DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415

Query: 335 SNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
            NT+GSY C C  G+  S DG  C D       +   +  C+QE        QC C  G
Sbjct: 416 ENTLGSYLCSCSVGFRLSVDGRSCED------INECSSSPCSQECANVYGSYQCYCRRG 468



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 95/297 (31%), Positives = 125/297 (42%), Gaps = 75/297 (25%)

Query: 114 ICRNSCGDGFCSRPNMCTCSSGQISSTCGSK-SIQQC---SVRCMNGGTCADDH----CQ 165
           IC+N+ G   C RP +  C SG I    G+   I +C   S  C  G TC +      CQ
Sbjct: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335

Query: 166 -----CQKGYI----GTYCGQ-----PVCENGCQNGGRCI---GPNRCACVYGFTGPQCE 208
                C +GY     GT C       P  E  C  G RC+   G  RC C  G+      
Sbjct: 336 KNVPNCGRGYHLNEEGTRCVDVDECAPPAEP-CGKGHRCVNSPGSFRCECKTGY------ 388

Query: 209 RDYRTGPCFTQVNNQMCQ---GQLTGIVCTKTL----CCATIG---RAWGHPCE---MCP 255
             Y  G     V+   CQ   G+L G  C  TL    C  ++G      G  CE    C 
Sbjct: 389 --YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS 446

Query: 256 AQPQP-------------CRRGF-IPNIRTGACQDVDECQAIPG--ICQGGNCINTVGSF 299
           + P               CRRG+ + ++    C+D+DEC    G  IC    CIN  GSF
Sbjct: 447 SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSF 505

Query: 300 ECRCP-AGHKQSETTQKCEDIDECSIIPGI--CETGE-CSNTVGSYFCV---CPRGY 349
           +C CP +G++ +   + C+DIDEC  + GI  C   E C N  G + C+   CP  Y
Sbjct: 506 QCSCPSSGYRLAPNGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCLAFECPENY 560



 Score = 68.9 bits (167), Expect = 7e-11
 Identities = 87/372 (23%), Positives = 142/372 (38%), Gaps = 83/372 (22%)

Query: 2410 CCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTM 2469
            CC DG R   HQ + C LP              Y T+ +   EC+++   C    C + +
Sbjct: 36   CCADGHRMATHQKD-CSLP--------------YATESK---ECRMVQEQC----CHSQL 73

Query: 2470 GSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPR-GYVLQEDGK 2528
                C       T IS  +  + D C+ +P   N   + T     C C   G   Q  G+
Sbjct: 74   EELHC------ATGISLAN--EQDRCA-TPHGDNASLEATFVKRCCHCCLLGRAAQAQGQ 124

Query: 2529 TCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGIC 2588
            +C+                 + + G+ C            C+ + E G         G  
Sbjct: 125  SCE----------------YSLMVGYQCG-----QVFRACCVKSQETGDLDV-----GGL 158

Query: 2589 QNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQ 2648
            Q T      E ++    +   LN    D C G   C+  C++      C C  GY     
Sbjct: 159  QETDKIIEVEEEQ----EDPYLN----DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSD 210

Query: 2649 WNQCVDENEC-SNPNACG-SASCYNTLGSYKC----ACPSGFSFDQFSSACHDVNECSSS 2702
               C D NEC +  ++C    SC NT+GS++C    +C +G+   +  ++C D++EC S 
Sbjct: 211  GVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESG 269

Query: 2703 KNPC--NYGCSNTEGGYLC----GCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENA 2756
             + C  ++ C NT G + C     C  G+ +   G+C+     N+   +S    +     
Sbjct: 270  IHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCID---INECLSISAPCPIG-HTC 325

Query: 2757 LSPEACYECKIN 2768
            ++ E  Y C+ N
Sbjct: 326  INTEGSYTCQKN 337


>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
          Length = 566

 Score =  231 bits (589), Expect = 8e-60
 Identities = 132/372 (35%), Positives = 192/372 (51%), Gaps = 38/372 (10%)

Query: 1131 CVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCR-GGTCVNTEGSFQCD----C 1185
            C +T     C CF GY+       +C D++EC      CR G +C+NT GSF+C     C
Sbjct: 190  CRDTGDEVVCSCFVGYQL-LSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248

Query: 1186 PLGHELSPSREDCVDINECSLSDNLCR-NGKCVNMIGTYQC----SCNPGYQATPDRQG- 1239
              G+EL+     C DI+EC    + C  +  C N +G+++C     C  G+    D  G 
Sbjct: 249  GTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF--IQDALGN 305

Query: 1240 CTDIDECMIMNGGCDT--QCTNSEGSYEC-----SCSEGYALMPDGRSCADIDECENNPD 1292
            C DI+EC+ ++  C     C N+EGSY C     +C  GY L  +G  C D+DEC    +
Sbjct: 306  CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAE 365

Query: 1293 ICDGG-QCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICH 1351
             C  G +C N PG +RC C  G+      + C+DVNEC          +CENT GS++C 
Sbjct: 366  PCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCS 425

Query: 1352 CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW---IGNGIKCID 1408
            C +G+ +      C D++EC     +      C N+ GS++C CR G+     +G+ C D
Sbjct: 426  CSVGFRLSVDGRSCEDINECS----SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481

Query: 1409 LDECS--NGTHQCSINAQCVNTPGSYRCAC-SEGF--TGDGFTCSDVDECAENINLCE-N 1462
            +DEC+   G H CS   +C+N PGS++C+C S G+    +G  C D+DEC   I+ C  N
Sbjct: 482  IDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539

Query: 1463 GQCLNVPGAYRC 1474
              C N+ G +RC
Sbjct: 540  ETCFNIQGGFRC 551



 Score =  221 bits (562), Expect = 1e-56
 Identities = 143/424 (33%), Positives = 193/424 (45%), Gaps = 68/424 (16%)

Query: 2215 DECSIGNPCGNGTCTNVIGSFECNCNEGFEP-GPMMNCEDINECAQNPLLCAF--RCMNT 2271
            D C  G PC    C +      C+C  G++     ++CED+NEC      C     C+NT
Sbjct: 178  DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 2272 FGSYEC----TCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI----C 2323
             GS+ C    +C  GY L ED   CKD+DEC  G+H+C     +C+N +G+F C     C
Sbjct: 237  VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLP-DFICQNTLGSFRCRPKLQC 294

Query: 2324 PPGMARRPDGEGCVDENECRTKPGICENGR-CVNIIGSYRCE-----CNEGFQSSSSGTE 2377
              G  +   G  C+D NEC +    C  G  C+N  GSY C+     C  G+  +  GT 
Sbjct: 295  KSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353

Query: 2378 CLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKIC 2437
            C+D  +                        +E C     G GH+C     PG+ +    C
Sbjct: 354  CVDVDE--------------------CAPPAEPC-----GKGHRC--VNSPGSFR----C 382

Query: 2438 PHGPGYTTDGR-----DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDL 2492
                GY  DG      D++EC+  P      +C NT+GS+ C C VG+   + G SC D+
Sbjct: 383  ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI 442

Query: 2493 DECSQSPKPCNYICKNTEGSYQCSCPRGYVLQE-DGKTCKDLDEC--QTKQHNCQFLCVN 2549
            +ECS S  PC+  C N  GSYQC C RGY L + DG TC+D+DEC   T  H C + C+N
Sbjct: 443  NECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCIN 500

Query: 2550 TLGGFTCKCPPG---FTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSC---ECQRGF 2603
              G F C CP        +   C D +EC +    C     C N  G F C   EC   +
Sbjct: 501  IPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560

Query: 2604 SLDA 2607
               A
Sbjct: 561  RRSA 564



 Score =  213 bits (541), Expect = 3e-54
 Identities = 139/393 (35%), Positives = 185/393 (47%), Gaps = 57/393 (14%)

Query: 2363 CECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQC 2422
            C C  G+Q  S G  C D  + +  +      C++  S  N V    C  D   G G++ 
Sbjct: 199  CSCFVGYQLLSDGVSCEDVNECITGSHS----CRLGESCINTVGSFRCQRDSSCGTGYEL 254

Query: 2423 ELCPLPGTAQYKKICPHGPGYTTDG--RDIDECKV-MPNLCTNGQCINTMGSFRCF---- 2475
                                 T D   +DIDEC+  + N   +  C NT+GSFRC     
Sbjct: 255  ---------------------TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQ 293

Query: 2476 CKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQC-----SCPRGYVLQEDGK 2528
            CK G+  D  G +CID++EC     PC   + C NTEGSY C     +C RGY L E+G 
Sbjct: 294  CKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT 352

Query: 2529 TCKDLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG--FTQHHTACIDNNECGSQPS-LCG 2583
             C D+DEC      C     CVN+ G F C+C  G  F      C+D NEC   P  LCG
Sbjct: 353  RCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG 412

Query: 2584 AKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGY 2643
             K  C+NT GS+ C C  GF L   G +CED++EC  +  C   C N+ G Y+C C +GY
Sbjct: 413  HK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP-CSQECANVYGSYQCYCRRGY 469

Query: 2644 -IQHYQWNQCVDENECSNPNACGSAS--CYNTLGSYKCACPS-GFSFDQFSSACHDVNEC 2699
             +       C D +EC+ P      S  C N  GS++C+CPS G+        C D++EC
Sbjct: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 2700 SSSKNPC--NYGCSNTEGGYLC---GCPPGYYR 2727
             +  + C  N  C N +GG+ C    CP  Y R
Sbjct: 530  VTGIHNCSINETCFNIQGGFRCLAFECPENYRR 562



 Score =  211 bits (536), Expect = 1e-53
 Identities = 145/414 (35%), Positives = 202/414 (48%), Gaps = 62/414 (14%)

Query: 1942 PCGNGTCKNTVGSYNCLCYPGFELTHNN-DCLDIDECSSFFGQVCRNGR-CFNEIGSFKC 1999
            PC    C++T     C C+ G++L  +   C D++EC +     CR G  C N +GSF+C
Sbjct: 185  PCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITG-SHSCRLGESCINTVGSFRC 242

Query: 2000 L----CNEGYELTPDGKNCIDTNECVALPGSCSPG-TCQNLEGSFRCI----CPPGY-EV 2049
                 C  GYELT D  +C D +EC +   +C P   CQN  GSFRC     C  G+ + 
Sbjct: 243  QRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD 301

Query: 2050 KSENCIDINECDEDPNICLFG-SCTNTPGGFQCL-----CPPGFVLSDNGRRCFDTRQSF 2103
               NCIDINEC      C  G +C NT G + C      C  G+ L++ G RC D  +  
Sbjct: 302  ALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE-- 359

Query: 2104 CFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVP 2163
                     C+ P       A+ C       G G  C   P     +F+  C  G+    
Sbjct: 360  ---------CAPP-------AEPC-------GKGHRCVNSPG----SFRCECKTGY-YFD 391

Query: 2164 SLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPC 2223
             +     DVNEC   PG     +C NT GS+ C C +G+ L   G  C D +ECS  +PC
Sbjct: 392  GISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPC 450

Query: 2224 GNGTCTNVIGSFECNCNEGFEPGPM--MNCEDINECA--QNPLLCAFRCMNTFGSYECTC 2279
                C NV GS++C C  G++   +  + CEDI+ECA      +C++RC+N  GS++C+C
Sbjct: 451  SQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSC 509

Query: 2280 P-IGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI---CPPGMAR 2329
            P  GY L  + + C+D+DEC  G+H+C S    C N+ G F C+   CP    R
Sbjct: 510  PSSGYRLAPNGRNCQDIDECVTGIHNC-SINETCFNIQGGFRCLAFECPENYRR 562



 Score =  207 bits (528), Expect = 9e-53
 Identities = 177/614 (28%), Positives = 242/614 (39%), Gaps = 122/614 (19%)

Query: 1166 PLLCRGGTC-----VNTEGSFQCDCPLGHELSPSREDC-----VDINECSLSDNLCRNGK 1215
            PLL  GG       V+ +   +  C  GH ++  ++DC      +  EC +    C    
Sbjct: 13   PLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQC---- 68

Query: 1216 CVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNG-GCDTQCTNSEGSYECSCSEGYAL 1274
            C + +    C+         DR        C   +G     + T  +    C C  G A 
Sbjct: 69   CHSQLEELHCATGISLANEQDR--------CATPHGDNASLEATFVKRCCHC-CLLGRAA 119

Query: 1275 MPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYD---------GFMASMDMKTCID 1325
               G+SC           +  G QC  +   +R  C           G +   D    ++
Sbjct: 120  QAQGQSC--------EYSLMVGYQCGQV---FRACCVKSQETGDLDVGGLQETDKIIEVE 168

Query: 1326 VNECD--LNSNICMFG-----ECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNC 1378
              + D  LN   C  G     +C +T    +C C +GY +      C DV+EC  G+H+C
Sbjct: 169  EEQEDPYLNDR-CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSC 227

Query: 1379 DMHASCLNIPGSFKC----SCREGW-IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYR 1433
             +  SC+N  GSF+C    SC  G+ +     C D+DEC +G H C  +  C NT GS+R
Sbjct: 228  RLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFR 287

Query: 1434 C----ACSEGFTGDGF-TCSDVDECAENINLCENGQ-CLNVPGAYRCE-----CEMGFTP 1482
            C     C  GF  D    C D++EC      C  G  C+N  G+Y C+     C  G+  
Sbjct: 288  CRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHL 347

Query: 1483 ASDSRSCQDIDECS-FQNICVFG-TCNNLPGMFHCICDDGYELDRTGGNCTDIDECAD-P 1539
              +   C D+DEC+     C  G  C N PG F C C  GY  D     C D++EC   P
Sbjct: 348  NEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYP 407

Query: 1540 INCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGV 1599
                   C NT G Y C+C   F+L+  G  C D  +  C          S  C+ E   
Sbjct: 408  GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED--INEC---------SSSPCSQECAN 456

Query: 1600 GVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPG 1659
                  C C  G                  Y L         +   +  EDIDEC     
Sbjct: 457  VYGSYQCYCRRG------------------YQL--------SDVDGVTCEDIDEC----A 486

Query: 1660 LCQGGN-----CINTFGSFQCECP-QGYYLSEDTRICEDIDECFAHPGVCGPG-TCYNTL 1712
            L  GG+     CIN  GSFQC CP  GY L+ + R C+DIDEC      C    TC+N  
Sbjct: 487  LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQ 546

Query: 1713 GNYTCI---CPPEY 1723
            G + C+   CP  Y
Sbjct: 547  GGFRCLAFECPENY 560



 Score =  204 bits (518), Expect = 1e-51
 Identities = 136/408 (33%), Positives = 186/408 (45%), Gaps = 61/408 (14%)

Query: 2264 CAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMC-- 2321
            C  +C +T     C+C +GY L  D   C+D++EC  G H C   G  C N +G+F C  
Sbjct: 186  CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRL-GESCINTVGSFRCQR 244

Query: 2322 --ICPPGMARRPDGEGCVDENECRTKPGIC-ENGRCVNIIGSYRC----ECNEGFQSSSS 2374
               C  G     D   C D +EC +    C  +  C N +GS+RC    +C  GF   + 
Sbjct: 245  DSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDAL 303

Query: 2375 GTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYK 2434
            G  C+D  + L     +   C +                     GH C       T Q K
Sbjct: 304  GN-CIDINECLS----ISAPCPI---------------------GHTCINTEGSYTCQ-K 336

Query: 2435 KICPHGPGYTTDGR-----DIDECKVMPNLCTNG-QCINTMGSFRCFCKVGYTTDISGTS 2488
             +   G GY  +       D+DEC      C  G +C+N+ GSFRC CK GY  D     
Sbjct: 337  NVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRM 396

Query: 2489 CIDLDECSQSP-KPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLC 2547
            C+D++EC + P + C + C+NT GSY CSC  G+ L  DG++C+D++EC +    C   C
Sbjct: 397  CVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQEC 454

Query: 2548 VNTLGGFTCKCPPGFTQHHT---ACIDNNECGSQPS--LCGAKGICQNTPGSFSCEC-QR 2601
             N  G + C C  G+         C D +EC       +C  +  C N PGSF C C   
Sbjct: 455  ANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR--CINIPGSFQCSCPSS 512

Query: 2602 GFSLDATGLNCEDVDEC-DGNHRCQ--HGCQNILGGYRC---GCPQGY 2643
            G+ L   G NC+D+DEC  G H C     C NI GG+RC    CP+ Y
Sbjct: 513  GYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560



 Score =  196 bits (497), Expect = 4e-49
 Identities = 124/364 (34%), Positives = 170/364 (46%), Gaps = 48/364 (13%)

Query: 2412 CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYT--TDG---RDIDECKVMPNLCTNGQ-C 2465
            C GG     QC           + +C    GY   +DG    D++EC    + C  G+ C
Sbjct: 180  CRGGGPCKQQCR------DTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESC 233

Query: 2466 INTMGSFRC----FCKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQC---- 2515
            INT+GSFRC     C  GY       SC D+DEC      C  ++IC+NT GS++C    
Sbjct: 234  INTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292

Query: 2516 SCPRGYVLQEDGKTCKDLDECQTKQHNCQF--LCVNTLGGFTCK-----CPPGF--TQHH 2566
             C  G++    G  C D++EC +    C     C+NT G +TC+     C  G+   +  
Sbjct: 293  QCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEG 351

Query: 2567 TACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECD--GNHRC 2624
            T C+D +EC      CG    C N+PGSF CEC+ G+  D     C DV+EC       C
Sbjct: 352  TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLC 411

Query: 2625 QHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGF 2684
             H C+N LG Y C C  G+        C D NECS+ + C S  C N  GSY+C C  G+
Sbjct: 412  GHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS-SPC-SQECANVYGSYQCYCRRGY 469

Query: 2685 SF-DQFSSACHDVNECS--SSKNPCNYGCSNTEGGYLCGCPPGYYRVGQG--------HC 2733
               D     C D++EC+  +  + C+Y C N  G + C CP   YR+            C
Sbjct: 470  QLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 2734 VSGM 2737
            V+G+
Sbjct: 530  VTGI 533



 Score =  194 bits (493), Expect = 1e-48
 Identities = 135/401 (33%), Positives = 185/401 (46%), Gaps = 58/401 (14%)

Query: 970  RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAV 1029
            +C ++     C C  G  L   G  C D+           +ECI         ++C   V
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDV-----------NECITGSHSCRLGESCINTV 237

Query: 1030 GAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGK- 1088
            G+     C+     GT                G  LT     KDI+EC++    C     
Sbjct: 238  GSF---RCQRDSSCGT----------------GYELTEDNSCKDIDECESGIHNCLPDFI 278

Query: 1089 CRNTIGSFKCR----CNSGFALDMEERNCTDIDECRISPDLCGSG-ICVNTPGSFECE-- 1141
            C+NT+GSF+CR    C SGF  D    NC DI+EC      C  G  C+NT GS+ C+  
Sbjct: 279  CQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKN 337

Query: 1142 ---CFEGY---ESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEGSFQCDCPLGHELSPS 1194
               C  GY   E G      C+D+DEC      C +G  CVN+ GSF+C+C  G+     
Sbjct: 338  VPNCGRGYHLNEEG----TRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI 393

Query: 1195 REDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD 1254
               CVD+NEC          KC N +G+Y CSC+ G++ + D + C DI+EC   +  C 
Sbjct: 394  SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCS 451

Query: 1255 TQCTNSEGSYECSCSEGYALMP-DGRSCADIDEC--ENNPDICDGGQCTNIPGEYRCLC- 1310
             +C N  GSY+C C  GY L   DG +C DIDEC       IC   +C NIPG ++C C 
Sbjct: 452  QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCP 510

Query: 1311 YDGFMASMDMKTCIDVNECDLNSNICMFGE-CENTKGSFIC 1350
              G+  + + + C D++EC    + C   E C N +G F C
Sbjct: 511  SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  194 bits (492), Expect = 1e-48
 Identities = 138/435 (31%), Positives = 197/435 (45%), Gaps = 70/435 (16%)

Query: 1803 TGKAVDIDECKEIPGI---CANG-----VCINQIGSFRCECPTGFSYNDLLLVCEDIDEC 1854
            T K ++++E +E P +   C  G      C +      C C  G+      + CED++EC
Sbjct: 161  TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220

Query: 1855 SNGDNLCQRNADCINSPGSYRCE----CAAGFKLSPNGACVDRNECLE-IPNVCSHGLCV 1909
              G + C+    CIN+ GS+RC+    C  G++L+ + +C D +EC   I N     +C 
Sbjct: 221  ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ 280

Query: 1910 DLQGSYQCI----CHNGFKASQDQT-MCMDVDECER--HPCGNG-TCKNTVGSYNCL--- 1958
            +  GS++C     C +GF   QD    C+D++EC     PC  G TC NT GSY C    
Sbjct: 281  NTLGSFRCRPKLQCKSGF--IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338

Query: 1959 --CYPGFELTHNND-CLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCI 2015
              C  G+ L      C+D+DEC+       +  RC N  GSF+C C  GY      + C+
Sbjct: 339  PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 2016 DTNECVALPGSCSPGTCQNLEGSFRCICPPGY--EVKSENCIDINECDEDPNICLFGSCT 2073
            D NEC   PG      C+N  GS+ C C  G+   V   +C DINEC   P       C 
Sbjct: 399  DVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECA 455

Query: 2074 NTPGGFQCLCPPGFVLSD-NGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMP 2132
            N  G +QC C  G+ LSD +G  C D             +C++P   +    +C    +P
Sbjct: 456  NVYGSYQCYCRRGYQLSDVDGVTCEDI-----------DECALPTGGHICSYRCI--NIP 502

Query: 2133 GEGWGDPCELCPKDDEVAFQDLCP-YGHGTVPSLHDTREDVNECLESPGICS-NGQCINT 2190
            G                +FQ  CP  G+   P+  +  +D++EC+     CS N  C N 
Sbjct: 503  G----------------SFQCSCPSSGYRLAPNGRNC-QDIDECVTGIHNCSINETCFNI 545

Query: 2191 DGSFRC---ECPMGY 2202
             G FRC   ECP  Y
Sbjct: 546  QGGFRCLAFECPENY 560



 Score =  184 bits (467), Expect = 1e-45
 Identities = 130/381 (34%), Positives = 174/381 (45%), Gaps = 67/381 (17%)

Query: 493 QTIDICKHHANLCLNGR-CIPTVSSYRCE----CNMGYKQDANGDCIDVDECTS---NPC 544
           + ++ C   ++ C  G  CI TV S+RC+    C  GY+   +  C D+DEC S   N  
Sbjct: 215 EDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCL 274

Query: 545 TNGDCVNTPGSYYCK----CHAGFQRTPTKQACIDIDECIQNGVLCKNGR-CVNTDGSFQ 599
            +  C NT GS+ C+    C +GF +      CIDI+EC+     C  G  C+NT+GS+ 
Sbjct: 275 PDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYT 333

Query: 600 C-----ICNAGFELTTDGKNCVDHDECT-TTNMCLNG-MCINEDGSFKCICKPGFVLAPN 652
           C      C  G+ L  +G  CVD DEC      C  G  C+N  GSF+C CK G+     
Sbjct: 334 CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI 393

Query: 653 GRYCTDVDECQT-PGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIK 711
            R C DV+ECQ  PG      C N+ GS+ C C  G  + +DGR C D            
Sbjct: 394 SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDI----------- 442

Query: 712 KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGIT-VDG---R 767
                         +EC           PC    A     +   C  G  ++ VDG    
Sbjct: 443 --------------NECS--------SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480

Query: 768 DINECALDP--DICANGICENLRGSYRCNC-NSGYEPDASGRNCIDIDECLVNRLLCD-N 823
           DI+ECAL     IC+   C N+ GS++C+C +SGY    +GRNC DIDEC+     C  N
Sbjct: 481 DIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539

Query: 824 GLCRNTPGSYSC---TCPPGY 841
             C N  G + C    CP  Y
Sbjct: 540 ETCFNIQGGFRCLAFECPENY 560



 Score =  170 bits (430), Expect = 2e-41
 Identities = 135/409 (33%), Positives = 177/409 (43%), Gaps = 73/409 (17%)

Query: 537 DECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGR-CVNTD 595
           D C         C +T     C C  G+Q      +C D++ECI     C+ G  C+NT 
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237

Query: 596 GSFQC----ICNAGFELTTDGKNCVDHDECTT-TNMCL-NGMCINEDGSFKCI----CKP 645
           GSF+C     C  G+ELT D  +C D DEC +  + CL + +C N  GSF+C     CK 
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 646 GFVLAPNGRYCTDVDECQTPGI-CMNGH-CINSEGSFRC-----DCPPGLAVGMDGRVCV 698
           GF+    G  C D++EC +    C  GH CIN+EGS+ C     +C  G  +  +G  CV
Sbjct: 297 GFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 699 DTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSS 758
           D                           EC       G G  C   P     E    C +
Sbjct: 356 DV-------------------------DECAPPAEPCGKGHRCVNSPGSFRCE----CKT 386

Query: 759 GV---GITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL 815
           G    GI+    D+NEC   P       CEN  GSY C+C+ G+     GR+C DI+EC 
Sbjct: 387 GYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS 446

Query: 816 VNRLLCDNGLCRNTPGSYSCTCPPGY-VFRTETETCEDINEC---ESNPCVNGACRNNLG 871
            +    +   C N  GSY C C  GY +   +  TCEDI+EC         +  C N  G
Sbjct: 447 SSPCSQE---CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPG 503

Query: 872 SFNCEC-SPGSKLSSTGLICID-----------SLKGTCWLNIQDS-RC 907
           SF C C S G +L+  G  C D           S+  TC+ NIQ   RC
Sbjct: 504 SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCF-NIQGGFRC 551



 Score =  164 bits (416), Expect = 9e-40
 Identities = 135/444 (30%), Positives = 187/444 (42%), Gaps = 91/444 (20%)

Query: 1464 QCLNVPGAYRCECEMGFTPASDSRSCQDIDEC-SFQNICVFG-TCNNLPGMFHC----IC 1517
            QC +      C C +G+   SD  SC+D++EC +  + C  G +C N  G F C     C
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248

Query: 1518 DDGYELDRTGGNCTDIDECADPI-NCV-NGLCVNTPGRYECNCPPDFQLNPTGVGCVDNR 1575
              GYEL     +C DIDEC   I NC+ + +C NT G + C   P  Q      G + + 
Sbjct: 249  GTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCR--PKLQCKS---GFIQDA 302

Query: 1576 VGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPG 1635
            +GNC           +  N  + +     S  C +G        TC  +N+   YT    
Sbjct: 303  LGNC-----------IDINECLSI-----SAPCPIG-------HTC--INTEGSYTCQKN 337

Query: 1636 ----GEGFRPNPITIILEDIDECQELPGLC-QGGNCINTFGSFQCECPQGYYLSEDTRIC 1690
                G G+  N       D+DEC      C +G  C+N+ GSF+CEC  GYY    +R+C
Sbjct: 338  VPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC 397

Query: 1691 EDIDECFAHPG-VCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTC 1749
             D++EC  +PG +CG   C NTLG+Y C C   +     G +C D+ +       + + C
Sbjct: 398  VDVNECQRYPGRLCG-HKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC------SSSPC 450

Query: 1750 ENELPFNVTKRMCCCT--YNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAV 1807
              E         C C   Y +       CE                              
Sbjct: 451  SQECANVYGSYQCYCRRGYQLSDVDGVTCE------------------------------ 480

Query: 1808 DIDECKEIPG--ICANGVCINQIGSFRCECP-TGFSYNDLLLVCEDIDECSNGDNLCQRN 1864
            DIDEC    G  IC+   CIN  GSF+C CP +G+        C+DIDEC  G + C  N
Sbjct: 481  DIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSIN 539

Query: 1865 ADCINSPGSYRC---ECAAGFKLS 1885
              C N  G +RC   EC   ++ S
Sbjct: 540  ETCFNIQGGFRCLAFECPENYRRS 563



 Score =  157 bits (397), Expect = 1e-37
 Identities = 174/605 (28%), Positives = 234/605 (38%), Gaps = 128/605 (21%)

Query: 592  VNTDGSFQCICNAGFELTTDGKNC-----VDHDECTTTNMCLNGMCINEDGSFKCICKPG 646
            V+ D   +  C  G  + T  K+C      +  EC    M     C ++     C    G
Sbjct: 27   VDADVLLEACCADGHRMATHQKDCSLPYATESKEC---RMVQEQCCHSQLEELHCAT--G 81

Query: 647  FVLAPNGRYCTDVDECQTPGICMNGHCINSEGSF--RCD--CPPGLAVGMDGRVCVDTHM 702
              LA       + D C TP    +G   + E +F  RC   C  G A    G+ C  + M
Sbjct: 82   ISLA------NEQDRCATP----HGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLM 131

Query: 703  RSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGI 762
                 G + +  CV+                               S E   L   G+  
Sbjct: 132  VGYQCGQVFRACCVK-------------------------------SQETGDLDVGGLQE 160

Query: 763  TVDGRDINECALDP---DICANG-----ICENLRGSYRCNCNSGYEPDASGRNCIDIDEC 814
            T    ++ E   DP   D C  G      C +      C+C  GY+  + G +C D++EC
Sbjct: 161  TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC 220

Query: 815  LVNRLLCDNG-LCRNTPGSYSC----TCPPGYVFRTETETCEDINECES---NPCVNGAC 866
            +     C  G  C NT GS+ C    +C  GY   TE  +C+DI+ECES   N   +  C
Sbjct: 221  ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDFIC 279

Query: 867  RNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGA 926
            +N LGSF C      KL        D+L G C          ++IN     S  C     
Sbjct: 280  QNTLGSFRCR----PKLQCKSGFIQDAL-GNC----------IDINECLSISAPCPI--- 321

Query: 927  AWGSPCERCELDTACPRGLARI--------KGVTCEDVNECEVFPGVCPNG-RCVNSKGS 977
              G  C   E    C + +           +G  C DV+EC      C  G RCVNS GS
Sbjct: 322  --GHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGS 379

Query: 978  FHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVG---AAWG 1034
            F CEC  G   DG  R+C+D+   Q Y       C H          C C+VG   +  G
Sbjct: 380  FRCECKTGYYFDGISRMCVDVNECQRY---PGRLCGHKCENTLGSYLCSCSVGFRLSVDG 436

Query: 1035 TECE---ECPK-PGTKE-------YETLCPRGAGFANRGDVLTGRPFYKDINECKAFPG- 1082
              CE   EC   P ++E       Y+  C RG   ++   V       +DI+EC    G 
Sbjct: 437  RSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTC-----EDIDECALPTGG 491

Query: 1083 -MCTYGKCRNTIGSFKCRC-NSGFALDMEERNCTDIDECRISPDLCG-SGICVNTPGSFE 1139
             +C+Y +C N  GSF+C C +SG+ L    RNC DIDEC      C  +  C N  G F 
Sbjct: 492  HICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFR 550

Query: 1140 CECFE 1144
            C  FE
Sbjct: 551  CLAFE 555



 Score =  144 bits (363), Expect = 1e-33
 Identities = 118/398 (29%), Positives = 172/398 (43%), Gaps = 86/398 (21%)

Query: 273 ACQDVDECQAIPGICQ-GGNCINTVGSFECR----CPAGHKQSETTQKCEDIDEC-SIIP 326
           +C+DV+EC      C+ G +CINTVGSF C+    C  G++ +E    C+DIDEC S I 
Sbjct: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIH 271

Query: 327 GICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKM 386
                  C NT+GS+               RC  +    C SG +     Q+  G     
Sbjct: 272 NCLPDFICQNTLGSF---------------RCRPKL--QCKSGFI-----QDALGN---- 305

Query: 387 QCCCEPGRCWGIGTIPEACPVRGS---EEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFA 443
             C +   C  I      CP+  +    E    C   +P                     
Sbjct: 306 --CIDINECLSISA---PCPIGHTCINTEGSYTCQKNVPN-------------------- 340

Query: 444 PSGNGNGYGPGGTGFIPI--------PGGNGF----SPGVGGAGVGAGGQGPIITGLTIL 491
             G G      GT  + +        P G G     SPG        G       G++ +
Sbjct: 341 -CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY---FDGISRM 396

Query: 492 NQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANG-DCIDVDECTSNPCTNGDCV 550
              ++ C+ +       +C  T+ SY C C++G++   +G  C D++EC+S+PC+  +C 
Sbjct: 397 CVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQ-ECA 455

Query: 551 NTPGSYYCKCHAGFQRTPTK-QACIDIDECI--QNGVLCKNGRCVNTDGSFQCIC-NAGF 606
           N  GSY C C  G+Q +      C DIDEC     G +C + RC+N  GSFQC C ++G+
Sbjct: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCPSSGY 514

Query: 607 ELTTDGKNCVDHDECTT--TNMCLNGMCINEDGSFKCI 642
            L  +G+NC D DEC T   N  +N  C N  G F+C+
Sbjct: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552



 Score = 99.0 bits (245), Expect = 6e-20
 Identities = 99/327 (30%), Positives = 134/327 (40%), Gaps = 51/327 (15%)

Query: 97  CCPGWKTLPGG------NQCIV--------PICRNSCGDGFCSRPNMCTCSSGQISSTCG 142
           C  G++ L  G      N+CI           C N+ G   C R + C  +  +++    
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG-TGYELTEDNS 259

Query: 143 SKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNG------GRCIGPNRC 196
            K I +C     N   C  D   CQ   +G++  +P  +  C++G      G CI  N C
Sbjct: 260 CKDIDECESGIHN---CLPDFI-CQNT-LGSFRCRPKLQ--CKSGFIQDALGNCIDINEC 312

Query: 197 A-----CVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLT--GIVCTKTLCCATIGRAWG- 248
                 C  G T    E  Y    C   V N      L   G  C     CA      G 
Sbjct: 313 LSISAPCPIGHTCINTEGSYT---CQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGK 369

Query: 249 -HPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAG 306
            H C   P   +  C+ G+  +  +  C DV+ECQ  PG   G  C NT+GS+ C C  G
Sbjct: 370 GHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVG 429

Query: 307 HKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGY-VTSTDGSRC--IDQRT 363
            + S   + CEDI+ECS  P  C   EC+N  GSY C C RGY ++  DG  C  ID+  
Sbjct: 430 FRLSVDGRSCEDINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486

Query: 364 GMCFSGLVNGRCAQELPGRMTKMQCCC 390
                 + + RC   +PG     QC C
Sbjct: 487 LPTGGHICSYRCI-NIPG---SFQCSC 509



 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 81/299 (27%), Positives = 113/299 (37%), Gaps = 66/299 (22%)

Query: 152 RCMNGGTCADDHCQCQKGYIGTYC----GQPVCENG--CQNGGRCI-GPNRC----ACVY 200
           RC  GG C     QC+       C    G  +  +G  C++   CI G + C    +C+ 
Sbjct: 179 RCRGGGPCKQ---QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235

Query: 201 GFTGPQCERDYRTGP---------------CFTQVNNQM----CQGQLTGIVCTKTLCCA 241
                +C+RD   G                C + ++N +    CQ  L    C   L C 
Sbjct: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 242 T--IGRAWGH------------PCEM------------CPAQPQPCRRGFIPNIRTGACQ 275
           +  I  A G+            PC +            C      C RG+  N     C 
Sbjct: 296 SGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 276 DVDECQAIPGIC-QGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGEC 334
           DVDEC      C +G  C+N+ GSF C C  G+     ++ C D++EC   PG     +C
Sbjct: 356 DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415

Query: 335 SNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
            NT+GSY C C  G+  S DG  C D       +   +  C+QE        QC C  G
Sbjct: 416 ENTLGSYLCSCSVGFRLSVDGRSCED------INECSSSPCSQECANVYGSYQCYCRRG 468



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 95/297 (31%), Positives = 125/297 (42%), Gaps = 75/297 (25%)

Query: 114 ICRNSCGDGFCSRPNMCTCSSGQISSTCGSK-SIQQC---SVRCMNGGTCADDH----CQ 165
           IC+N+ G   C RP +  C SG I    G+   I +C   S  C  G TC +      CQ
Sbjct: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335

Query: 166 -----CQKGYI----GTYCGQ-----PVCENGCQNGGRCI---GPNRCACVYGFTGPQCE 208
                C +GY     GT C       P  E  C  G RC+   G  RC C  G+      
Sbjct: 336 KNVPNCGRGYHLNEEGTRCVDVDECAPPAEP-CGKGHRCVNSPGSFRCECKTGY------ 388

Query: 209 RDYRTGPCFTQVNNQMCQ---GQLTGIVCTKTL----CCATIG---RAWGHPCE---MCP 255
             Y  G     V+   CQ   G+L G  C  TL    C  ++G      G  CE    C 
Sbjct: 389 --YFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS 446

Query: 256 AQPQP-------------CRRGF-IPNIRTGACQDVDECQAIPG--ICQGGNCINTVGSF 299
           + P               CRRG+ + ++    C+D+DEC    G  IC    CIN  GSF
Sbjct: 447 SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSF 505

Query: 300 ECRCP-AGHKQSETTQKCEDIDECSIIPGI--CETGE-CSNTVGSYFCV---CPRGY 349
           +C CP +G++ +   + C+DIDEC  + GI  C   E C N  G + C+   CP  Y
Sbjct: 506 QCSCPSSGYRLAPNGRNCQDIDEC--VTGIHNCSINETCFNIQGGFRCLAFECPENY 560



 Score = 68.9 bits (167), Expect = 7e-11
 Identities = 87/372 (23%), Positives = 142/372 (38%), Gaps = 83/372 (22%)

Query: 2410 CCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTM 2469
            CC DG R   HQ + C LP              Y T+ +   EC+++   C    C + +
Sbjct: 36   CCADGHRMATHQKD-CSLP--------------YATESK---ECRMVQEQC----CHSQL 73

Query: 2470 GSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPR-GYVLQEDGK 2528
                C       T IS  +  + D C+ +P   N   + T     C C   G   Q  G+
Sbjct: 74   EELHC------ATGISLAN--EQDRCA-TPHGDNASLEATFVKRCCHCCLLGRAAQAQGQ 124

Query: 2529 TCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGIC 2588
            +C+                 + + G+ C            C+ + E G         G  
Sbjct: 125  SCE----------------YSLMVGYQCG-----QVFRACCVKSQETGDLDV-----GGL 158

Query: 2589 QNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQ 2648
            Q T      E ++    +   LN    D C G   C+  C++      C C  GY     
Sbjct: 159  QETDKIIEVEEEQ----EDPYLN----DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSD 210

Query: 2649 WNQCVDENEC-SNPNACG-SASCYNTLGSYKC----ACPSGFSFDQFSSACHDVNECSSS 2702
               C D NEC +  ++C    SC NT+GS++C    +C +G+   +  ++C D++EC S 
Sbjct: 211  GVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESG 269

Query: 2703 KNPC--NYGCSNTEGGYLC----GCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENA 2756
             + C  ++ C NT G + C     C  G+ +   G+C+     N+   +S    +     
Sbjct: 270  IHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCID---INECLSISAPCPIG-HTC 325

Query: 2757 LSPEACYECKIN 2768
            ++ E  Y C+ N
Sbjct: 326  INTEGSYTCQKN 337


>gi|10190748 CEGP1 protein [Homo sapiens]
          Length = 999

 Score =  228 bits (581), Expect = 7e-59
 Identities = 141/414 (34%), Positives = 200/414 (48%), Gaps = 54/414 (13%)

Query: 1200 DINECSLSDNLCR-NGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDEC-MIMNGGCDTQC 1257
            D++EC+   + C  +  C N   +Y+CSC PGYQ   + + C DIDEC   +NGGC   C
Sbjct: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQG--EGRQCEDIDECGNELNGGCVHDC 102

Query: 1258 TNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMAS 1317
             N  G+Y C+C +G+ L  DG +C D+DEC  N   C    C N+ G Y C C +GF  S
Sbjct: 103  LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLS 161

Query: 1318 MDMKTCIDVNECDLN--------SNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVD 1369
             +  TCI  +E  L+        S+IC     E  +GS  C C+ G+ + K    C  + 
Sbjct: 162  DNQHTCIHRSEEGLSCMNKDHGCSHICK----EAPRGSVACECRPGFELAKNQRDC--IL 215

Query: 1370 ECEIGAHNCDMHASCLNIPGSFKCSCREGWI--GNGIKCIDLDEC------SNGT----- 1416
             C  G   C    SC +     +CSC   +    +G  C++ ++       SN T     
Sbjct: 216  TCNHGNGGCQH--SCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDG 273

Query: 1417 ----------HQCSIN-----AQCVNTPGSYRCACSEGFTG--DGFTCSDVDECAENINL 1459
                        C++N       C +T     C+C  GFT   DG TC D+DEC      
Sbjct: 274  DKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG 333

Query: 1460 CENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDD 1519
            C++  C N+ G++ C C+ GF   +D +SCQD+DECS    C   +C N PG F C C+ 
Sbjct: 334  CDHF-CKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDH-SCINHPGTFACACNR 391

Query: 1520 GYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVD 1573
            GY L     +C D +EC+        +CVNT G YEC C P ++L+     CV+
Sbjct: 392  GYTLYGFT-HCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVE 444



 Score =  214 bits (544), Expect = 1e-54
 Identities = 140/445 (31%), Positives = 192/445 (43%), Gaps = 86/445 (19%)

Query: 2252 EDINECAQNPLLCAFR--CMNTFGSYECTCPIGYALREDQKMCKDLDECAEGL-----HD 2304
            ED++ECAQ    C     C NT  SY+C+C  GY  + + + C+D+DEC   L     HD
Sbjct: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHD 101

Query: 2305 CESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCE 2364
            C        N+ G + C C  G     DG  C+D +EC    G C++  CVN++GSY C 
Sbjct: 102  C-------LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECC 153

Query: 2365 CNEGFQSSSSGTECLD-NRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCE 2423
            C EGF  S +   C+  + +GL                         C +   G  H C+
Sbjct: 154  CKEGFFLSDNQHTCIHRSEEGLS------------------------CMNKDHGCSHICK 189

Query: 2424 LCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNG---QCINTMGSFRCFCKVGY 2480
              P    A     C   PG+    ++  +C +  N    G    C +T     C C   Y
Sbjct: 190  EAPRGSVA-----CECRPGFEL-AKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQY 243

Query: 2481 TTDISGTSCID----------------------------LDECSQSPKPCNYICKNTEGS 2512
                 G SC++                            ++ C+ +   C+  CK+T   
Sbjct: 244  KMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTG 303

Query: 2513 YQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGF--TQHHTACI 2570
              CSCP G+ LQ DGKTCKD+DECQT+   C   C N +G F C C  GF       +C 
Sbjct: 304  VHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQ 363

Query: 2571 DNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECD-GNHRCQHGCQ 2629
            D +EC S    C     C N PG+F+C C RG++L     +C D +EC   N  CQ  C 
Sbjct: 364  DVDEC-SLDRTCDHS--CINHPGTFACACNRGYTLYGF-THCGDTNECSINNGGCQQVCV 419

Query: 2630 NILGGYRCGCPQGYIQHYQWNQCVD 2654
            N +G Y C C  GY  H+    CV+
Sbjct: 420  NTVGSYECQCHPGYKLHWNKKDCVE 444



 Score =  206 bits (523), Expect = 4e-52
 Identities = 135/412 (32%), Positives = 192/412 (46%), Gaps = 19/412 (4%)

Query: 1892 DRNECLEIPNVC-SHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGT--C 1948
            D +EC +  + C +  LC +   SY+C C  G++    Q  C D+DEC     G     C
Sbjct: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CEDIDECGNELNGGCVHDC 102

Query: 1949 KNTVGSYNCLCYPGFELTHN-NDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYEL 2007
             N  G+Y C C+ GF L H+ ++CLD+DEC    G  C++  C N +GS++C C EG+ L
Sbjct: 103  LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGG-CQH-TCVNVMGSYECCCKEGFFL 160

Query: 2008 TPDGKNCIDTNE----CVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDED 2063
            + +   CI  +E    C+     CS    +   GS  C C PG+E+       I  C+  
Sbjct: 161  SDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHG 220

Query: 2064 PNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTK 2123
               C   SC +T  G +C C P + +  +GR C + R+       E+   SV       K
Sbjct: 221  NGGCQH-SCDDTADGPECSCHPQYKMHTDGRSCLE-REDTVLEVTESNTTSVVDGDKRVK 278

Query: 2124 AKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICS 2183
             +           G  C+   KD        CP G  T+     T +D++EC    G C 
Sbjct: 279  RRLLMETCAVNNGG--CDRTCKDTSTGVHCSCPVGF-TLQLDGKTCKDIDECQTRNGGCD 335

Query: 2184 NGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGF 2243
            +  C N  GSF C C  G+ L      C D DECS+   C + +C N  G+F C CN G+
Sbjct: 336  HF-CKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDH-SCINHPGTFACACNRGY 393

Query: 2244 EPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDL 2295
                  +C D NEC+ N   C   C+NT GSYEC C  GY L  ++K C ++
Sbjct: 394  TLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445



 Score =  186 bits (473), Expect = 2e-46
 Identities = 125/414 (30%), Positives = 176/414 (42%), Gaps = 51/414 (12%)

Query: 1158 DIDECERNPLLCRGGT-CVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKC 1216
            D+DEC +    C     C NT  S++C C  G++       C DI+EC    N      C
Sbjct: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVHDC 102

Query: 1217 VNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMP 1276
            +N+ G Y+C+C  G+    D   C D+DEC+  NGGC   C N  GSYEC C EG+ L  
Sbjct: 103  LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSD 162

Query: 1277 DGRSCADIDE----CENNPDICDGGQCTNIP-GEYRCLCYDGFMASMDMKTCIDVNECDL 1331
            +  +C    E    C N    C    C   P G   C C  GF  + + + CI    C+ 
Sbjct: 163  NQHTCIHRSEEGLSCMNKDHGCSH-ICKEAPRGSVACECRPGFELAKNQRDCILT--CNH 219

Query: 1332 NSNICMFGECENTKGSFICHCQLGYSV------------------KKGTTGCTDVDE--- 1370
             +  C    C++T     C C   Y +                  +  TT   D D+   
Sbjct: 220  GNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVK 278

Query: 1371 -------CEIGAHNCDMHASCLNIPGSFKCSCREGWIG--NGIKCIDLDECSNGTHQCSI 1421
                   C +    CD   +C +      CSC  G+    +G  C D+DEC      C  
Sbjct: 279  RRLLMETCAVNNGGCDR--TCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGC-- 334

Query: 1422 NAQCVNTPGSYRCACSEGFT--GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMG 1479
            +  C N  GS+ C C +GF    D  +C DVDEC+ +   C++  C+N PG + C C  G
Sbjct: 335  DHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLD-RTCDHS-CINHPGTFACACNRG 392

Query: 1480 FTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDI 1533
            +T    +  C D +ECS  N      C N  G + C C  GY+L     +C ++
Sbjct: 393  YTLYGFTH-CGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445



 Score =  185 bits (469), Expect = 6e-46
 Identities = 130/416 (31%), Positives = 188/416 (45%), Gaps = 29/416 (6%)

Query: 1367 DVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCV 1426
            DVDEC  G  +C   A C N P S+KCSC+ G+ G G +C D+DEC N  +   ++  C+
Sbjct: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVH-DCL 103

Query: 1427 NTPGSYRCACSEGF--TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPAS 1484
            N PG+YRC C +GF    DG  C DVDEC EN   C++  C+NV G+Y C C+ GF  + 
Sbjct: 104  NIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSD 162

Query: 1485 DSRSCQDIDE----CSFQNICVFGTCNNLP-GMFHCICDDGYELDRTGGNCTDIDECADP 1539
            +  +C    E    C  ++      C   P G   C C  G+EL +   +C  I  C   
Sbjct: 163  NQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHG 220

Query: 1540 INCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGS-LSCNTEIG 1598
                   C +T    EC+C P ++++  G  C++    +  L+       S +  +  + 
Sbjct: 221  NGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERE--DTVLEVTESNTTSVVDGDKRVK 278

Query: 1599 VGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELP 1658
              +   +C  + G      C+      ST  +  CP G   + +  T   +DIDECQ   
Sbjct: 279  RRLLMETCAVNNG-----GCDRTCKDTSTGVHCSCPVGFTLQLDGKT--CKDIDECQTRN 331

Query: 1659 GLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCI 1718
            G C    C N  GSF C C +G+ L  D + C+D+DEC +    C   +C N  G + C 
Sbjct: 332  GGCD-HFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC-SLDRTC-DHSCINHPGTFACA 388

Query: 1719 CPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNK 1774
            C   Y  + G  +C D  +     S N   C+      V    C C       WNK
Sbjct: 389  CNRGY-TLYGFTHCGDTNEC----SINNGGCQQVCVNTVGSYECQCHPGYKLHWNK 439



 Score =  184 bits (467), Expect = 1e-45
 Identities = 130/440 (29%), Positives = 176/440 (40%), Gaps = 77/440 (17%)

Query: 2324 PPGMARRPDGEGCVDENECRTKPGICE-NGRCVNIIGSYRCECNEGFQSSSSGTECLDNR 2382
            PPG  R    +  VDE  C      C  +  C N   SY+C C  G+Q      E +D  
Sbjct: 33   PPGRGRAAGPQEDVDE--CAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDID-- 88

Query: 2383 QGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPG 2442
                                      EC  +   G  H C    +PG   Y+  C  G  
Sbjct: 89   --------------------------ECGNELNGGCVHDC--LNIPGN--YRCTCFDGFM 118

Query: 2443 YTTDGR---DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDE----C 2495
               DG    D+DEC      C +  C+N MGS+ C CK G+    +  +CI   E    C
Sbjct: 119  LAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSC 177

Query: 2496 SQSPKPCNYICKNT-EGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGF 2554
                  C++ICK    GS  C C  G+ L ++ + C  +  C      CQ  C +T  G 
Sbjct: 178  MNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGP 235

Query: 2555 TCKCPPGFTQHH--------------------TACIDNNECGSQPSLC--------GAKG 2586
             C C P +  H                     T+ +D ++   +  L         G   
Sbjct: 236  ECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDR 295

Query: 2587 ICQNTPGSFSCECQRGFSLDATGLNCEDVDECDG-NHRCQHGCQNILGGYRCGCPQGYIQ 2645
             C++T     C C  GF+L   G  C+D+DEC   N  C H C+NI+G + CGC +G+  
Sbjct: 296  TCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKL 355

Query: 2646 HYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNP 2705
                  C D +ECS    C   SC N  G++ CAC  G++   F+  C D NECS +   
Sbjct: 356  LTDEKSCQDVDECSLDRTCDH-SCINHPGTFACACNRGYTLYGFTH-CGDTNECSINNGG 413

Query: 2706 CNYGCSNTEGGYLCGCPPGY 2725
            C   C NT G Y C C PGY
Sbjct: 414  CQQVCVNTVGSYECQCHPGY 433



 Score =  182 bits (462), Expect = 4e-45
 Identities = 136/429 (31%), Positives = 181/429 (42%), Gaps = 88/429 (20%)

Query: 529 ANGDCIDVDECTS--NPC-TNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVL 585
           A G   DVDEC    + C  +  C NTP SY C C  G+Q    +  C DIDEC      
Sbjct: 39  AAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CEDIDECGNE--- 93

Query: 586 CKNGRCV----NTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKC 641
             NG CV    N  G+++C C  GF L  DG NC+D DEC   N      C+N  GS++C
Sbjct: 94  -LNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYEC 152

Query: 642 ICKPGFVLAPNGRYCTDVDECQTPGICMN-----GHCINS--EGSFRCDCPPGLAVGMDG 694
            CK GF L+ N   C  +   +    CMN      H       GS  C+C PG  +  + 
Sbjct: 153 CCKEGFFLSDNQHTC--IHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQ 210

Query: 695 RVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGF---GEPC---------- 741
           R C+      TC  G   G C           EC C +P Y     G  C          
Sbjct: 211 RDCI-----LTCNHG--NGGCQHSCDDTADGPECSC-HPQYKMHTDGRSCLEREDTVLEV 262

Query: 742 ---------------------QPCPAKN----------SAEFHGLCSSGVGITVDG---R 767
                                + C   N          S   H  C  G  + +DG   +
Sbjct: 263 TESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCK 322

Query: 768 DINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCR 827
           DI+EC      C +  C+N+ GS+ C C  G++     ++C D+DEC ++R  CD+  C 
Sbjct: 323 DIDECQTRNGGC-DHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDR-TCDHS-CI 379

Query: 828 NTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACR----NNLGSFNCECSPGSKL 883
           N PG+++C C  GY     T  C D NEC  N   NG C+    N +GS+ C+C PG KL
Sbjct: 380 NHPGTFACACNRGYTLYGFTH-CGDTNECSIN---NGGCQQVCVNTVGSYECQCHPGYKL 435

Query: 884 SSTGLICID 892
                 C++
Sbjct: 436 HWNKKDCVE 444



 Score =  173 bits (439), Expect = 2e-42
 Identities = 136/450 (30%), Positives = 191/450 (42%), Gaps = 86/450 (19%)

Query: 1804 GKAVDIDECKEIPGIC-ANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDN-LC 1861
            G   D+DEC +    C A+ +C N   S++C C  G+        CEDIDEC N  N  C
Sbjct: 41   GPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CEDIDECGNELNGGC 98

Query: 1862 QRNADCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICH 1920
                DC+N PG+YRC C  GF L+ +G  C+D +ECLE    C H  CV++ GSY+C C 
Sbjct: 99   VH--DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCK 155

Query: 1921 NGFKASQDQTMCMDVDE----C--ERHPCGNGTCKNTVGSYNCLCYPGFELTHN-NDCLD 1973
             GF  S +Q  C+   E    C  + H C +   +   GS  C C PGFEL  N  DC  
Sbjct: 156  EGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC-- 213

Query: 1974 IDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNE-------------- 2019
            I  C+   G  C++  C +     +C C+  Y++  DG++C++  +              
Sbjct: 214  ILTCNHGNGG-CQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVV 271

Query: 2020 --------------CVALPGSCSPGTCQNLEGSFRCICPPGY--EVKSENCIDINECDED 2063
                          C    G C   TC++      C CP G+  ++  + C DI+EC   
Sbjct: 272  DGDKRVKRRLLMETCAVNNGGCD-RTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTR 330

Query: 2064 PNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTK 2123
               C    C N  G F C C  GF L  + + C D             +CS+ +  + + 
Sbjct: 331  NGGC-DHFCKNIVGSFDCGCKKGFKLLTDEKSCQDV-----------DECSLDRTCDHS- 377

Query: 2124 AKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICS 2183
                C   PG                 F   C  G+      H    D NEC  + G C 
Sbjct: 378  ----CINHPG----------------TFACACNRGYTLYGFTH--CGDTNECSINNGGCQ 415

Query: 2184 NGQCINTDGSFRCECPMGYNLDYTGVRCVD 2213
               C+NT GS+ C+C  GY L +    CV+
Sbjct: 416  Q-VCVNTVGSYECQCHPGYKLHWNKKDCVE 444



 Score =  172 bits (436), Expect = 4e-42
 Identities = 107/361 (29%), Positives = 149/361 (41%), Gaps = 47/361 (13%)

Query: 2412 CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR---DIDECKVMPNLCTNGQCINT 2468
            C  G    H   LC    T+ YK  C   PGY  +GR   DIDEC    N      C+N 
Sbjct: 49   CAQGLDDCHADALCQNTPTS-YKCSCK--PGYQGEGRQCEDIDECGNELNGGCVHDCLNI 105

Query: 2469 MGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGK 2528
             G++RC C  G+     G +C+D+DEC ++   C + C N  GSY+C C  G+ L ++  
Sbjct: 106  PGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQH 165

Query: 2529 TCKDLDE----CQTKQHNCQFLCVNT-LGGFTCKCPPGF--TQHHTACIDNNECGSQPSL 2581
            TC    E    C  K H C  +C     G   C+C PGF   ++   CI     G+    
Sbjct: 166  TCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNG--- 222

Query: 2582 CGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC-------------DGNHR----- 2623
             G +  C +T     C C   + +   G +C + ++              DG+ R     
Sbjct: 223  -GCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRL 281

Query: 2624 -----------CQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNT 2672
                       C   C++   G  C CP G+        C D +EC   N      C N 
Sbjct: 282  LMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNI 341

Query: 2673 LGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGH 2732
            +GS+ C C  GF       +C DV+ECS  +  C++ C N  G + C C  GY   G  H
Sbjct: 342  VGSFDCGCKKGFKLLTDEKSCQDVDECSLDRT-CDHSCINHPGTFACACNRGYTLYGFTH 400

Query: 2733 C 2733
            C
Sbjct: 401  C 401



 Score =  170 bits (430), Expect = 2e-41
 Identities = 124/425 (29%), Positives = 184/425 (43%), Gaps = 42/425 (9%)

Query: 1973 DIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECV-ALPGSCSPGT 2031
            D+DEC+        +  C N   S+KC C  GY+   +G+ C D +EC   L G C    
Sbjct: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVHD- 101

Query: 2032 CQNLEGSFRCICPPGYEVKSE--NCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVL 2089
            C N+ G++RC C  G+ +  +  NC+D++EC E+   C   +C N  G ++C C  GF L
Sbjct: 102  CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFL 160

Query: 2090 SDNGRRCFD-TRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDE 2148
            SDN   C   + +     N ++G   + K     +    C   PG       EL     +
Sbjct: 161  SDNQHTCIHRSEEGLSCMNKDHGCSHICK--EAPRGSVACECRPG------FELAKNQRD 212

Query: 2149 VAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGS--FRCECPMGYNLDY 2206
                  C +G+G      D   D  EC      C     ++TDG      E  +    + 
Sbjct: 213  CILT--CNHGNGGCQHSCDDTADGPECS-----CHPQYKMHTDGRSCLEREDTVLEVTES 265

Query: 2207 TGVRCVDTDE----------CSIGNPCGNGTCTNVIGSFECNCNEGFEPG-PMMNCEDIN 2255
                 VD D+          C++ N   + TC +      C+C  GF        C+DI+
Sbjct: 266  NTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDID 325

Query: 2256 ECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNL 2315
            EC      C   C N  GS++C C  G+ L  D+K C+D+DEC+     C+     C N 
Sbjct: 326  ECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLD-RTCDH---SCINH 381

Query: 2316 IGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSG 2375
             GTF C C  G         C D NEC    G C+   CVN +GSY C+C+ G++   + 
Sbjct: 382  PGTFACACNRGYTLY-GFTHCGDTNECSINNGGCQQ-VCVNTVGSYECQCHPGYKLHWNK 439

Query: 2376 TECLD 2380
             +C++
Sbjct: 440  KDCVE 444



 Score =  169 bits (429), Expect = 3e-41
 Identities = 133/476 (27%), Positives = 194/476 (40%), Gaps = 83/476 (17%)

Query: 493 QTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNG---DC 549
           Q +D C H   LC N     T +SY+C C  GY+ +    C D+DEC  N    G   DC
Sbjct: 51  QGLDDC-HADALCQN-----TPTSYKCSCKPGYQGEGR-QCEDIDEC-GNELNGGCVHDC 102

Query: 550 VNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELT 609
           +N PG+Y C C  GF        C+D+DEC++N   C++  CVN  GS++C C  GF L+
Sbjct: 103 LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLS 161

Query: 610 TDGKNCVDHDE----CTTTNMCLNGMCINED-GSFKCICKPGFVLAPNGRYCTDVDECQT 664
            +   C+   E    C   +   + +C     GS  C C+PGF LA N R C  +  C  
Sbjct: 162 DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNH 219

Query: 665 PGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTH----------------------- 701
                   C ++     C C P   +  DGR C++                         
Sbjct: 220 GNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKR 279

Query: 702 --MRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGF-----GEPCQP---CPAKNSA- 750
             +  TC   +  G C R      T   C C     GF     G+ C+    C  +N   
Sbjct: 280 RLLMETC--AVNNGGCDRTCKDTSTGVHCSCP---VGFTLQLDGKTCKDIDECQTRNGGC 334

Query: 751 ---------EFHGLCSSGVGITVDGR---DINECALDPDICANGICENLRGSYRCNCNSG 798
                     F   C  G  +  D +   D++EC+LD     +  C N  G++ C CN G
Sbjct: 335 DHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRT--CDHSCINHPGTFACACNRG 392

Query: 799 YEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDIN---E 855
           Y       +C D +EC +N   C   +C NT GSY C C PGY      + C ++     
Sbjct: 393 YTLYGF-THCGDTNECSINNGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLP 450

Query: 856 CESNPCVNGACRNNLGSFNC--ECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEV 909
              +P V+  C  + G   C   C  G  LSS     + +++ +    + + +C +
Sbjct: 451 TSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSD----VTTIRTSVTFKLNEGKCSL 502



 Score =  169 bits (428), Expect = 4e-41
 Identities = 134/466 (28%), Positives = 189/466 (40%), Gaps = 88/466 (18%)

Query: 940  ACPRGLARIKGVTCEDVNECEVFPGVC-PNGRCVNSKGSFHCECPEGLTLDGTGRVCLDI 998
            A P G  R  G   EDV+EC      C  +  C N+  S+ C C  G    G GR C DI
Sbjct: 31   AVPPGRGRAAGPQ-EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDI 87

Query: 999  RMEQCYLKWDEDECIHP---VPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRG 1055
              ++C  + +   C+H    +PG +R   C C  G     +   C               
Sbjct: 88   --DECGNELNGG-CVHDCLNIPGNYR---CTCFDGFMLAHDGHNC--------------- 126

Query: 1056 AGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTD 1115
                             D++EC    G C +  C N +GS++C C  GF L   +  C  
Sbjct: 127  ----------------LDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIH 169

Query: 1116 IDECRIS---PDLCGSGICVNTP-GSFECECFEGYESGFMMMKNCMD-IDECERNPLLCR 1170
              E  +S    D   S IC   P GS  CEC  G+E    + KN  D I  C      C+
Sbjct: 170  RSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFE----LAKNQRDCILTCNHGNGGCQ 225

Query: 1171 GGTCVNTEGSFQCDCPLGHELSPSREDCVD----------------------------IN 1202
              +C +T    +C C   +++      C++                            + 
Sbjct: 226  H-SCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLME 284

Query: 1203 ECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEG 1262
             C++++  C +  C +      CSC  G+    D + C DIDEC   NGGCD  C N  G
Sbjct: 285  TCAVNNGGC-DRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVG 343

Query: 1263 SYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKT 1322
            S++C C +G+ L+ D +SC D+DEC  +   CD   C N PG + C C  G+        
Sbjct: 344  SFDCGCKKGFKLLTDEKSCQDVDECSLD-RTCD-HSCINHPGTFACACNRGY-TLYGFTH 400

Query: 1323 CIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDV 1368
            C D NEC +N+  C    C NT GS+ C C  GY +      C +V
Sbjct: 401  CGDTNECSINNGGCQ-QVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445



 Score =  169 bits (427), Expect = 5e-41
 Identities = 127/465 (27%), Positives = 194/465 (41%), Gaps = 103/465 (22%)

Query: 575 DIDECIQNGVLCK-NGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCI 633
           D+DEC Q    C  +  C NT  S++C C  G++   +G+ C D DEC      LNG C+
Sbjct: 45  DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNE---LNGGCV 99

Query: 634 NE----DGSFKCICKPGFVLAPNGRYCTDVDEC-QTPGICMNGHCINSEGSFRCDCPPGL 688
           ++     G+++C C  GF+LA +G  C DVDEC +  G C +  C+N  GS+ C C  G 
Sbjct: 100 HDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHT-CVNVMGSYECCCKEGF 158

Query: 689 AVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKN 748
            +  +   C+                         ++    C N D+G    C+  P  +
Sbjct: 159 FLSDNQHTCIHR-----------------------SEEGLSCMNKDHGCSHICKEAPRGS 195

Query: 749 SAEFHGLCSSGVGITVDGRD-INECALDPDICANGICENLRGSYRCNCNSGYEPDASGRN 807
            A     C  G  +  + RD I  C      C +  C++      C+C+  Y+    GR+
Sbjct: 196 VA---CECRPGFELAKNQRDCILTCNHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGRS 251

Query: 808 CID----------------------------IDECLVNRLLCDNGLCRNTPGSYSCTCPP 839
           C++                            ++ C VN   CD   C++T     C+CP 
Sbjct: 252 CLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDR-TCKDTSTGVHCSCPV 310

Query: 840 GYVFRTETETCEDINECES-NPCVNGACRNNLGSFNCECSPGSKLSSTGLICID----SL 894
           G+  + + +TC+DI+EC++ N   +  C+N +GSF+C C  G KL +    C D    SL
Sbjct: 311 GFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSL 370

Query: 895 KGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCE 954
             TC     D  C +N  G                          AC RG        C 
Sbjct: 371 DRTC-----DHSC-INHPGT----------------------FACACNRGYTLYGFTHCG 402

Query: 955 DVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIR 999
           D NEC +  G C    CVN+ GS+ C+C  G  L    + C++++
Sbjct: 403 DTNECSINNGGCQQV-CVNTVGSYECQCHPGYKLHWNKKDCVEVK 446



 Score =  161 bits (408), Expect = 8e-39
 Identities = 135/457 (29%), Positives = 188/457 (41%), Gaps = 101/457 (22%)

Query: 1691 EDIDECFAHPGVC-GPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTC 1749
            ED+DEC      C     C NT  +Y C C P Y     G  C D+ +           C
Sbjct: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDE-----------C 90

Query: 1750 ENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDI 1809
             NEL          C ++        C   P     +++  C    GF         +D+
Sbjct: 91   GNELNGG-------CVHD--------CLNIP----GNYRCTC--FDGFMLAHDGHNCLDV 129

Query: 1810 DECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVC----EDIDECSNGDNLCQRNA 1865
            DEC E  G C +  C+N +GS+ C C  GF  +D    C    E+   C N D+ C    
Sbjct: 130  DECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHI- 187

Query: 1866 DCINSP-GSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHG------LCVDLQGSYQCI 1918
             C  +P GS  CEC  GF+L+ N     + +C+     C+HG       C D     +C 
Sbjct: 188  -CKEAPRGSVACECRPGFELAKN-----QRDCIL---TCNHGNGGCQHSCDDTADGPECS 238

Query: 1919 CHNGFKASQDQTMCMDVDEC-------------------------ERHPCGNG----TCK 1949
            CH  +K   D   C++ ++                          E     NG    TCK
Sbjct: 239  CHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCK 298

Query: 1950 NTVGSYNCLCYPGFELT-HNNDCLDIDECSSFFGQVCRNGRCF----NEIGSFKCLCNEG 2004
            +T    +C C  GF L      C DIDEC +      RNG C     N +GSF C C +G
Sbjct: 299  DTSTGVHCSCPVGFTLQLDGKTCKDIDECQT------RNGGCDHFCKNIVGSFDCGCKKG 352

Query: 2005 YELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKS-ENCIDINECDED 2063
            ++L  D K+C D +EC +L  +C   +C N  G+F C C  GY +    +C D NEC  +
Sbjct: 353  FKLLTDEKSCQDVDEC-SLDRTCDH-SCINHPGTFACACNRGYTLYGFTHCGDTNECSIN 410

Query: 2064 PNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR 2100
               C    C NT G ++C C PG+ L  N + C + +
Sbjct: 411  NGGCQ-QVCVNTVGSYECQCHPGYKLHWNKKDCVEVK 446



 Score =  157 bits (398), Expect = 1e-37
 Identities = 128/453 (28%), Positives = 180/453 (39%), Gaps = 67/453 (14%)

Query: 2132 PGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGIC-SNGQCINT 2190
            PG  W     L      +      P G G        +EDV+EC +    C ++  C NT
Sbjct: 9    PGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAG---PQEDVDECAQGLDDCHADALCQNT 65

Query: 2191 DGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGT---CTNVIGSFECNCNEGFEPG- 2246
              S++C C  GY  +  G +C D DEC  GN    G    C N+ G++ C C +GF    
Sbjct: 66   PTSYKCSCKPGYQGE--GRQCEDIDEC--GNELNGGCVHDCLNIPGNYRCTCFDGFMLAH 121

Query: 2247 PMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCE 2306
               NC D++EC +N   C   C+N  GSYEC C  G+ L ++Q  C    E  EGL  C 
Sbjct: 122  DGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE--EGL-SCM 178

Query: 2307 SRGMMCKNLI-----GTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSY 2361
            ++   C ++      G+  C C PG     +   C+    C    G C++  C +     
Sbjct: 179  NKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCI--LTCNHGNGGCQHS-CDDTADGP 235

Query: 2362 RCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSR-NLVTKSECCCDGGRGWGH 2420
             C C+  ++  + G  CL+    +       T   +    R       E C     G   
Sbjct: 236  ECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDR 295

Query: 2421 QCE--------LCPLPGTAQY----------------------KKI-------CPHGPGY 2443
             C+         CP+  T Q                       K I       C  G   
Sbjct: 296  TCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKL 355

Query: 2444 TTDGR---DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPK 2500
             TD +   D+DEC  +   C +  CIN  G+F C C  GYT     T C D +ECS +  
Sbjct: 356  LTDEKSCQDVDECS-LDRTCDHS-CINHPGTFACACNRGYTL-YGFTHCGDTNECSINNG 412

Query: 2501 PCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDL 2533
             C  +C NT GSY+C C  GY L  + K C ++
Sbjct: 413  GCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445



 Score =  117 bits (294), Expect = 1e-25
 Identities = 71/223 (31%), Positives = 99/223 (44%), Gaps = 14/223 (6%)

Query: 2559 PPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC 2618
            PPG  +      D +EC      C A  +CQNTP S+ C C+ G+     G  CED+DEC
Sbjct: 33   PPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDEC 90

Query: 2619 DG--NHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSY 2676
                N  C H C NI G YRC C  G++  +  + C+D +EC   N     +C N +GSY
Sbjct: 91   GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSY 150

Query: 2677 KCACPSGFSFDQFSSACHDVNE----CSSSKNPCNYGCSNT-EGGYLCGCPPGY-YRVGQ 2730
            +C C  GF        C   +E    C +  + C++ C     G   C C PG+     Q
Sbjct: 151  ECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQ 210

Query: 2731 GHCVSGMGFNKG--QYLSLDTEVDEENALSPEACYECKINGYS 2771
              C+       G  Q+   DT    E +  P+  Y+   +G S
Sbjct: 211  RDCILTCNHGNGGCQHSCDDTADGPECSCHPQ--YKMHTDGRS 251



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 49/133 (36%), Positives = 64/133 (48%), Gaps = 8/133 (6%)

Query: 261 CRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDID 320
           C  GF   +    C+D+DECQ   G C    C N VGSF+C C  G K     + C+D+D
Sbjct: 308 CPVGFTLQLDGKTCKDIDECQTRNGGCDHF-CKNIVGSFDCGCKKGFKLLTDEKSCQDVD 366

Query: 321 ECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELP 380
           ECS +   C+   C N  G++ C C RGY T    + C D  T  C   + NG C Q   
Sbjct: 367 ECS-LDRTCD-HSCINHPGTFACACNRGY-TLYGFTHCGD--TNEC--SINNGGCQQVCV 419

Query: 381 GRMTKMQCCCEPG 393
             +   +C C PG
Sbjct: 420 NTVGSYECQCHPG 432



 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 53/155 (34%), Positives = 70/155 (45%), Gaps = 12/155 (7%)

Query: 244 GRAWGHPCEMCPAQPQPCRRGFIPNIR---TGACQDVDEC-QAIPGICQGGNCINTVGSF 299
           G AW     +    P     G +P  R    G  +DVDEC Q +        C NT  S+
Sbjct: 10  GAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSY 69

Query: 300 ECRCPAGHKQSETTQKCEDIDEC-SIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRC 358
           +C C  G+ Q E  Q CEDIDEC + + G C   +C N  G+Y C C  G++ + DG  C
Sbjct: 70  KCSCKPGY-QGEGRQ-CEDIDECGNELNGGC-VHDCLNIPGNYRCTCFDGFMLAHDGHNC 126

Query: 359 IDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
           +D     C     NG C       M   +CCC+ G
Sbjct: 127 LD--VDECLEN--NGGCQHTCVNVMGSYECCCKEG 157



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 39/124 (31%), Positives = 57/124 (45%), Gaps = 8/124 (6%)

Query: 274 CQDVDEC-QAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG 332
           C+D+DEC   + G C   +C+N  G++ C C  G   +     C D+DEC    G C+  
Sbjct: 84  CEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ-H 141

Query: 333 ECSNTVGSYFCVCPRGYVTSTDGSRCIDQ-RTGMCFSGLVNG--RCAQELPGRMTKMQCC 389
            C N +GSY C C  G+  S +   CI +   G+      +G     +E P     + C 
Sbjct: 142 TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAP--RGSVACE 199

Query: 390 CEPG 393
           C PG
Sbjct: 200 CRPG 203



 Score = 53.1 bits (126), Expect = 4e-06
 Identities = 67/260 (25%), Positives = 99/260 (38%), Gaps = 57/260 (21%)

Query: 130 CTCSSGQISSTCGSKSIQ-QCSVRC-----MNGGTCAD-DHCQCQKGYIGTYCGQPVCEN 182
           C  ++G    TC   S    CS        ++G TC D D CQ + G          C++
Sbjct: 286 CAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG---------CDH 336

Query: 183 GCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCAT 242
            C+N    +G   C C  GF                  + + CQ           +   +
Sbjct: 337 FCKN---IVGSFDCGCKKGFK--------------LLTDEKSCQD----------VDECS 369

Query: 243 IGRAWGHPCEMCPAQ-PQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFEC 301
           + R   H C   P      C RG+     T  C D +EC    G CQ   C+NTVGS+EC
Sbjct: 370 LDRTCDHSCINHPGTFACACNRGYTLYGFTH-CGDTNECSINNGGCQQV-CVNTVGSYEC 427

Query: 302 RCPAGHKQSETTQKCEDID---ECSIIPGICETGECSNTVGSYFCV--CPRGYVTSTDGS 356
           +C  G+K     + C ++      S+ P +  +  C  + G   C   C  G   S+D +
Sbjct: 428 QCHPGYKLHWNKKDCVEVKGLLPTSVSPRV--SLHCGKSGGGDGCFLRCHSGIHLSSDVT 485

Query: 357 RCIDQRTGMCFSGLVNGRCA 376
                RT + F  L  G+C+
Sbjct: 486 TI---RTSVTFK-LNEGKCS 501



 Score = 42.7 bits (99), Expect = 0.005
 Identities = 54/194 (27%), Positives = 68/194 (35%), Gaps = 31/194 (15%)

Query: 1810 DECKEIPGICANGVCINQIGSFRCE-CPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCI 1868
            D  +E   +C NG   N+ G   CE CP     N   L   +    S    LCQ      
Sbjct: 648  DGARERCILCPNGTFQNEEGQMTCEPCPR--PGNSGALKTPEAWNMSECGGLCQ------ 699

Query: 1869 NSPGSYRCECAAGFKLSPNGAC---VDRNECLEIPNVCSHGLCVDLQG--SYQCICHNGF 1923
              PG Y  +  A  +L   G       R  C      C  GL    QG  S+Q  C    
Sbjct: 700  --PGEYSADGFAPCQLCALGTFQPEAGRTSCFP----CGGGLATKHQGATSFQD-CETRV 752

Query: 1924 KASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQ 1983
            + S           C R  C  GT +   G  NC+  PG      N   D D  ++    
Sbjct: 753  QCSPGHFYNTTTHRCIR--CPVGTYQPEFGKNNCVSCPG------NTTTDFDGSTNI--T 802

Query: 1984 VCRNGRCFNEIGSF 1997
             C+N RC  E+G F
Sbjct: 803  QCKNRRCGGELGDF 816



 Score = 42.0 bits (97), Expect = 0.009
 Identities = 49/213 (23%), Positives = 62/213 (29%), Gaps = 69/213 (32%)

Query: 249 HPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGH 307
           H C   P   +  C  GF+       C DVDEC    G CQ   C+N +GS+EC C  G 
Sbjct: 100 HDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGF 158

Query: 308 KQSETTQKCEDIDE-------------------------CSIIPGI------------CE 330
             S+    C    E                         C   PG             C 
Sbjct: 159 FLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCN 218

Query: 331 TGE------CSNTVGSYFCVCPRGYVTSTDGSRCIDQ----------------------- 361
            G       C +T     C C   Y   TDG  C+++                       
Sbjct: 219 HGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVK 278

Query: 362 -RTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
            R  M    + NG C +      T + C C  G
Sbjct: 279 RRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVG 311


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.140    0.487 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 152,529,062
Number of Sequences: 37866
Number of extensions: 9176369
Number of successful extensions: 90025
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 372
Number of HSP's successfully gapped in prelim test: 493
Number of HSP's that attempted gapping in prelim test: 31109
Number of HSP's gapped (non-prelim): 17879
length of query: 2912
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2792
effective length of database: 13,703,598
effective search space: 38260445616
effective search space used: 38260445616
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press