BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|6631102 protocadherin 8 isoform 1 precursor [Homo sapiens] (1070 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|6631102 protocadherin 8 isoform 1 precursor [Homo sapiens] 2133 0.0 gi|14589937 protocadherin 8 isoform 2 precursor [Homo sapiens] 1803 0.0 gi|14589929 protocadherin 18 precursor [Homo sapiens] 588 e-168 gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens] 520 e-147 gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens] 506 e-143 gi|94538350 protocadherin 17 precursor [Homo sapiens] 506 e-143 gi|157426847 protocadherin 19 isoform a [Homo sapiens] 471 e-132 gi|157426845 protocadherin 19 isoform b [Homo sapiens] 471 e-132 gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precurso... 448 e-125 gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precurs... 448 e-125 gi|7706113 protocadherin 12 precursor [Homo sapiens] 446 e-125 gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precurs... 439 e-123 gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precurs... 439 e-123 gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo sap... 439 e-123 gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo sapi... 439 e-123 gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo sapi... 438 e-122 gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens] 438 e-122 gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo sapi... 426 e-119 gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens] 426 e-119 gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens] 426 e-119 gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo sapi... 426 e-119 gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo sapi... 424 e-118 gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens] 424 e-118 gi|14165400 protocadherin alpha 1 isoform 2 precursor [Homo sapi... 422 e-118 gi|9256582 protocadherin alpha 1 isoform 1 precursor [Homo sapiens] 422 e-118 gi|9256594 protocadherin alpha 7 isoform 1 precursor [Homo sapiens] 422 e-118 gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precurs... 421 e-117 gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precur... 421 e-117 gi|14165381 protocadherin alpha 10 isoform 2 precursor [Homo sap... 421 e-117 gi|9256574 protocadherin alpha 10 isoform 1 precursor [Homo sapi... 421 e-117 >gi|6631102 protocadherin 8 isoform 1 precursor [Homo sapiens] Length = 1070 Score = 2133 bits (5528), Expect = 0.0 Identities = 1070/1070 (100%), Positives = 1070/1070 (100%) Query: 1 MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD 60 MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD Sbjct: 1 MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD 60 Query: 61 TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH 120 TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH Sbjct: 61 TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH 120 Query: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP Sbjct: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180 Query: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND Sbjct: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240 Query: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD 300 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD Sbjct: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD 300 Query: 301 PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA 360 PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA Sbjct: 301 PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA 360 Query: 361 APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD 420 APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD Sbjct: 361 APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD 420 Query: 421 SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480 SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV Sbjct: 421 SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480 Query: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE Sbjct: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540 Query: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL Sbjct: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600 Query: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE Sbjct: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660 Query: 661 AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720 AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA Sbjct: 661 AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720 Query: 721 PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780 PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE Sbjct: 721 PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780 Query: 781 VRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAP 840 VRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAP Sbjct: 781 VRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAP 840 Query: 841 PPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHS 900 PPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHS Sbjct: 841 PPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHS 900 Query: 901 FNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGH 960 FNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGH Sbjct: 901 FNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGH 960 Query: 961 SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK 1020 SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK Sbjct: 961 SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK 1020 Query: 1021 VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV 1070 VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV Sbjct: 1021 VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV 1070 >gi|14589937 protocadherin 8 isoform 2 precursor [Homo sapiens] Length = 973 Score = 1803 bits (4671), Expect = 0.0 Identities = 944/1070 (88%), Positives = 949/1070 (88%), Gaps = 97/1070 (9%) Query: 1 MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD 60 MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD Sbjct: 1 MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD 60 Query: 61 TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH 120 TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH Sbjct: 61 TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH 120 Query: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP Sbjct: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180 Query: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND Sbjct: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240 Query: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD 300 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD Sbjct: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD 300 Query: 301 PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA 360 PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA Sbjct: 301 PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA 360 Query: 361 APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD 420 APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD Sbjct: 361 APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD 420 Query: 421 SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480 SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV Sbjct: 421 SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480 Query: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE Sbjct: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540 Query: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL Sbjct: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600 Query: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE Sbjct: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660 Query: 661 AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720 AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA Sbjct: 661 AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720 Query: 721 PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780 PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE Sbjct: 721 PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780 Query: 781 VRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAP 840 GAS PG GK P AP Sbjct: 781 PY---------------GAS------------------------PGFGKEP-------AP 794 Query: 841 PPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHS 900 P AV G + +G A F G+ Sbjct: 795 PVAV----WKGHSFNTISGREAEKFSGKD------------------------------- 819 Query: 901 FNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGH 960 SG+ F+ DS DISGDALKKDLINHMQSGLWACTAECKILGH Sbjct: 820 ----SGKGDSDFNDSDS------------DISGDALKKDLINHMQSGLWACTAECKILGH 863 Query: 961 SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK 1020 SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK Sbjct: 864 SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK 923 Query: 1021 VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV 1070 VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV Sbjct: 924 VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV 973 >gi|14589929 protocadherin 18 precursor [Homo sapiens] Length = 1135 Score = 588 bits (1516), Expect = e-168 Identities = 363/1000 (36%), Positives = 535/1000 (53%), Gaps = 101/1000 (10%) Query: 30 KTVRYSTFEEDAPGTVIGTLAED-----LHMKVSGDTSFRLMKQFNSSLLRVREGDGQLT 84 K ++Y +EE G+VI L+ED L + FR M++ NS LL V E +G+++ Sbjct: 28 KNLKYRIYEEQRVGSVIARLSEDVADVLLKLPNPSTVRFRAMQRGNSPLLVVNEDNGEIS 87 Query: 85 VGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEV 144 +G A +DRE+LC + C + FDV++ E +L H+EVEV D+ND++P+F R+ IP+E+ Sbjct: 88 IG-ATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEI 146 Query: 145 SEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELD 204 SE AAVGTRIPL+ D DVG N L T L+ + F +E++TR DGA+ A+L++++ELD Sbjct: 147 SESAAVGTRIPLDSAFDPDVGENSLHTYSLSA-NDFFNIEVRTRTDGAKYAELIVVRELD 205 Query: 205 RESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSL 264 RE +++Y L+L A D G P RS ++ L + + D+ND+SPAF Q + ++L E++PVG+L Sbjct: 206 RELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYI-IQLLENSPVGTL 264 Query: 265 LLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDV 324 LLDL+A DPDEG NG +V++F + P+ F++D G LTL VDYE +YE+DV Sbjct: 265 LLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDV 324 Query: 325 RAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADA 384 +AQD GP A CK+I+++ DVNDN P+I I L +PG Sbjct: 325 QAQDLGPNSIPAHCKIIIKVVDVNDNKPEININ-LMSPGKE------------------- 364 Query: 385 SSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYA 444 S + EG ++ VALV D+DSG NG++ C L+GH HF+LQ Y Sbjct: 365 ------------EISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYE 412 Query: 445 GSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEV 504 +YL++T A+LDRE+ +EY+LT++AEDRG P L TV+ +TV++ D NDN P F R YE Sbjct: 413 NNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEF 472 Query: 505 SVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYAL 564 + ENN PGAY+ TV A D DLG NGQVTY +LE+ + G +++TYV++DP+ GAIYAL Sbjct: 473 VISENNSPGAYITTVTATDPDLGENGQVTYTILESFI--LGSSITTYVTIDPSNGAIYAL 530 Query: 565 RSFDYETLRQLDVRIQASDGGSP-QLSSSALVQVRVLDQNDHAPVLVHPAPANGSLEVAV 623 R FD+E + Q+ ++A DGGSP QL S+ V + ++D+ND+ PV++ PA N + E+ + Sbjct: 531 RIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITI 590 Query: 624 PGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPG 683 P V R++A D D G N EL+ + F I R+ +I T P Sbjct: 591 PKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDI-HTNVSMDSVPY 649 Query: 684 RVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSV 743 + ++I D G P L T + ++ E + S S S Sbjct: 650 TEWELSVIIQDKGNPQLHTKVLLKCMIF----------------EYAESVTSTAMTSVSQ 693 Query: 744 LQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPG 803 D +I+II L C +LL ++ AT CNR KK+ R E ++ Sbjct: 694 ASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAE--------STYQH 745 Query: 804 SPEEAARGAGPRPNMFDVLTFPGT-------GKAPFGSPAADAPPPAVAAAEVPGSEGGS 856 P+ +R + ++ V T GT +P SP + + S Sbjct: 746 HPKRPSRQI-HKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNS 804 Query: 857 ATGESACHFEGQQRLRGAHAEPYGASPG-----FGKEPAPPVAVWKGHSFN---TISGRE 908 S+ H L HA P + P ++G+ ++ + ++ Sbjct: 805 LVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQD 864 Query: 909 AEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLW-----------ACTAECKI 957 +KFS KDSG+GDS+ DSD D+ D+ L+ S L+ CT EC++ Sbjct: 865 MDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRV 924 Query: 958 LGHSDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDP 997 LGHSD+CW P PSP + + F P P Sbjct: 925 LGHSDQCWMPPL------PSPSSDYRSNMFIPGEEFPTQP 958 >gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens] Length = 1040 Score = 520 bits (1340), Expect = e-147 Identities = 364/1028 (35%), Positives = 516/1028 (50%), Gaps = 148/1028 (14%) Query: 15 LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVS--GDTSFRLMKQFNSS 72 L LF+L W++ S+ + Y+ EE GT +G +AEDL + ++ F+ + + Sbjct: 4 LLLFALLWMVEGVFSQ-LHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRTP 62 Query: 73 LLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHA 132 L + G L V + +DRE++C Q+P CVL +V F + L VE+EV D+ND+ Sbjct: 63 YLDLNLETGVLYVNEK-IDREQICKQSPSCVLHLEV--FLENPLELFQVEIEVLDINDNP 119 Query: 133 PRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGA 192 P FP + VE+SE A GTR PLE D DVG N L+ + P+S F +++QT+ DG Sbjct: 120 PSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT-PNSYFSLDVQTQGDGN 178 Query: 193 QCADLVLLQELDRESQAAYSLELVAQDGGR----------------PP---RSATAALSV 233 + A+LVL + LDRE QA + L A DGG PP R+ TA L++ Sbjct: 179 RFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTI 238 Query: 234 RVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEA 293 RVLD+ND+ PAF Q V V L E++P G+L++ L+A DPDEG NG+VV++F + P A Sbjct: 239 RVLDSNDNVPAFDQ-PVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRA 297 Query: 294 RRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPD 353 R LF L PR+GRL ++G +DYE Y++ V+A+D GP A CKV+VR+ D NDNAP+ Sbjct: 298 RELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPE 357 Query: 354 IAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVAL 413 I+ + + V EGAA ++VAL Sbjct: 358 ISFSTVK--------------------------------------EAVSEGAAPGTVVAL 379 Query: 414 VSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRG 473 S +DRDS NGQV+C L G FRL+ ++ Y +VT A LDRE Y LT+VA DRG Sbjct: 380 FSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRG 439 Query: 474 APPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVT 533 P L T + V+V D NDNAP F++PVY+V V ENN PGAY+ V+A DRD G N Q+ Sbjct: 440 EPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLA 499 Query: 534 YRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQ-LSSS 592 Y +LE ++ G +V TYVS++ G +YALRSFDYE L+ +++A D GSPQ L+ + Sbjct: 500 YSILECQI--QGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGN 557 Query: 593 ALVQVRVLDQNDHAPVLVHPAPA-NGSLEVAVPGRTAKDT-VVARVQARDADEGANGELA 650 A V + ++DQND+AP +V P P NG+ V R+A+ ++ RV A DAD+G N L Sbjct: 558 ATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLT 617 Query: 651 FELQQQEPREAFAIGRRTGEILLTGDL-SQEPPGRVFRALLVISDGGRPPLTTTAT--VS 707 + + + F + RTGE+ + ++ P R + ++ + D G+PPL++TAT V Sbjct: 618 YSIVRGNEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQ 677 Query: 708 FVVTAGGGRGPAAPASAGSPERSRPPGSRLGVS------------GSV------------ 743 V A +G GS E RP S G + GSV Sbjct: 678 LVDGAVEPQGGGGSGGGGSGEHQRPSRSGGGETSLDLTLILIIALGSVSFIFLLAMIVLA 737 Query: 744 --LQWDTPLIVIIVLAGSCTLLLAAIIAIATTC-----NRRKKEVRKGGALREERPGAAG 796 Q + L + LA C L +TC RKK++ K + + Sbjct: 738 VRCQKEKKLNIYTCLASDCCLCCCCCGGGGSTCCGRQARARKKKLSKSDIMLVQSSNVPS 797 Query: 797 GGASAPGSPEEAARGAGPRPN----MFDVLTFPGTGKAP--FGSPAADA--------PPP 842 A P E + G G + + V P + K F P + + P Sbjct: 798 NPAQVP---IEESGGFGSHHHNQNYCYQVCLTPESAKTDLMFLKPCSPSRSTDTEHNPCG 854 Query: 843 AVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHSFN 902 A+ + G + QR ++ V + N Sbjct: 855 AIVTGYTDQQPDIISNGSILSNETKHQRAELSYL------------------VDRPRRVN 896 Query: 903 TISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKK--DLINHMQSGLWACTAECKILGH 960 + + +EA+ S KDSG GDS+ DSD D + A DL ++ CT ECK LGH Sbjct: 897 SSAFQEADIVSSKDSGHGDSEQGDSDHDATNRAQSAGMDLFSN-------CTEECKALGH 949 Query: 961 SDRCWSPS 968 SDRCW PS Sbjct: 950 SDRCWMPS 957 >gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens] Length = 896 Score = 506 bits (1304), Expect = e-143 Identities = 315/792 (39%), Positives = 444/792 (56%), Gaps = 77/792 (9%) Query: 15 LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVS--GDTSFRLMKQFNSS 72 L LF+L W++ S+ + Y+ EE GT +G +AEDL + ++ F+ + + Sbjct: 4 LLLFALLWMVEGVFSQ-LHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRTP 62 Query: 73 LLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHA 132 L + G L V + +DRE++C Q+P CVL +V F + L VE+EV D+ND+ Sbjct: 63 YLDLNLETGVLYVNEK-IDREQICKQSPSCVLHLEV--FLENPLELFQVEIEVLDINDNP 119 Query: 133 PRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGA 192 P FP + VE+SE A GTR PLE D DVG N L+ + P+S F +++QT+ DG Sbjct: 120 PSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT-PNSYFSLDVQTQGDGN 178 Query: 193 QCADLVLLQELDRESQAAYSLELVAQDGGR----------------PP---RSATAALSV 233 + A+LVL + LDRE QA + L A DGG PP R+ TA L++ Sbjct: 179 RFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTI 238 Query: 234 RVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEA 293 RVLD+ND+ PAF Q V V L E++P G+L++ L+A DPDEG NG+VV++F + P A Sbjct: 239 RVLDSNDNVPAFDQ-PVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRA 297 Query: 294 RRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPD 353 R LF L PR+GRL ++G +DYE Y++ V+A+D GP A CKV+VR+ D NDNAP+ Sbjct: 298 RELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPE 357 Query: 354 IAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVAL 413 I+ + + V EGAA ++VAL Sbjct: 358 ISFSTVK--------------------------------------EAVSEGAAPGTVVAL 379 Query: 414 VSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRG 473 S +DRDS NGQV+C L G FRL+ ++ Y +VT A LDRE Y LT+VA DRG Sbjct: 380 FSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRG 439 Query: 474 APPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVT 533 P L T + V+V D NDNAP F++PVY+V V ENN PGAY+ V+A DRD G N Q+ Sbjct: 440 EPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLA 499 Query: 534 YRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQ-LSSS 592 Y +LE ++ G +V TYVS++ G +YALRSFDYE L+ +++A D GSPQ L+ + Sbjct: 500 YSILECQI--QGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGN 557 Query: 593 ALVQVRVLDQNDHAPVLVHPAPA-NGSLEVAVPGRTAK-DTVVARVQARDADEGANGELA 650 A V + ++DQND+AP +V P P NG+ V R+A+ ++ RV A DAD+G N L Sbjct: 558 ATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLT 617 Query: 651 FELQQQEPREAFAIGRRTGEILLTGDL-SQEPPGRVFRALLVISDGGRPPLTTTAT--VS 707 + + + F + RTGE+ + ++ P R + ++ + D G+PPL++TAT V Sbjct: 618 YSIVRGNEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQ 677 Query: 708 FVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAI 767 V A +G GS E RP SR G G D LI+II L + L A+ Sbjct: 678 LVDGAVEPQGGGGSGGGGSGEHQRP--SRSG--GGETSLDLTLILIIALGSVSFIFLLAM 733 Query: 768 IAIATTCNRRKK 779 I +A C + KK Sbjct: 734 IVLAVRCQKEKK 745 >gi|94538350 protocadherin 17 precursor [Homo sapiens] Length = 1159 Score = 506 bits (1303), Expect = e-143 Identities = 348/1013 (34%), Positives = 512/1013 (50%), Gaps = 138/1013 (13%) Query: 30 KTVRYSTFEEDAPGTVIGTLAEDLHMKV------------SGDTSFRLMKQFNSSLLRVR 77 K + YS EE GTVIG + D ++ S S+R+++ LL V Sbjct: 19 KNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAPHLLDV- 77 Query: 78 EGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPR 137 + D L +DRE LC +C L+ +V + +E + ++VE++D+ND+AP F Sbjct: 78 DADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKE---ICMIKVEIQDINDNAPSFSS 134 Query: 138 AQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLA-EPHSPFRVELQTRADGAQCAD 196 QI +++SE AA GTR PL D D G NGL+T L + H F +++++R DG + + Sbjct: 135 DQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPE 194 Query: 197 LVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELA 256 LV+ + LDRE Q ++L L A DGG PPRSAT ++V+V+D+ND+SP F + VEL Sbjct: 195 LVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYL-VELP 253 Query: 257 EDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYER 316 E+AP+G++++DL+A D DEGPNG+V+++F + P R LF +DP++G + + G +DYE Sbjct: 254 ENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEE 313 Query: 317 QDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAA 376 E+DV+A+D GP P A CKV V++ D NDNAP I + Sbjct: 314 NGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQ--------------- 358 Query: 377 AALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYG--- 433 G ++P G +++ALV +DRDSG NGQ++C + G Sbjct: 359 ---GALSEAAPPG-------------------TVIALVRVTDRDSGKNGQLQCRVLGGGG 396 Query: 434 ------------HEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVR 481 F+L+ Y Y VVT LDRE EYN+T+VA D G+PPL + + Sbjct: 397 TGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTK 456 Query: 482 PYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEV 541 + +++ DENDN P FT+ +Y + V ENN PG YL +V A+D DLG+NG V+Y +L + + Sbjct: 457 SFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHI 516 Query: 542 GRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSP-QLSSSALVQVRVL 600 G ++ TYVSV+P GAIYALRSF++E + + ++ A D G+P L S+A V+V VL Sbjct: 517 GDV--SIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVL 574 Query: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660 D ND+APV+V P N + E+ VP +V+ V+A D+D G +G L +E+ Sbjct: 575 DVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDH 634 Query: 661 AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720 F I +GEI T E V ++ ++D G+P T +A ++ + G P Sbjct: 635 LFEIDPSSGEI-RTLHPFWEDVTPVVELVVKVTDHGKP--TLSAVAKLIIRSVSGSLP-- 689 Query: 721 PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780 G P V+G WD L +I+ L+ +LLAA+I IA C R KE Sbjct: 690 ---EGVPR----------VNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKE 736 Query: 781 VRKGGA-LREERPGAAGGGASAPG----------SPEEAARGAGPRPNMFDVLTFPGTGK 829 +R + E GGG E R A N+ +V++ P Sbjct: 737 IRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNA---MNVMNVVSSPSLAT 793 Query: 830 APFGSPAADAPPPAVAAAEV----PGSEGGSA-TGESACH--FEGQQRLRGAHAEPYGAS 882 +P P + +EV P S + G + CH F GQ G +A A+ Sbjct: 794 SPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQ----GTNASETPAT 849 Query: 883 P----GFGKEPAPPVAVWKGHSF--NTISGREAEKFSGKDSGKGDSDFNDSDSDIS---- 932 PA P + F ++ + ++ E+ S +DSG GDSD DSD D + Sbjct: 850 RMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSC 909 Query: 933 -----GDALKKDLINHMQSGLWA-------CTAECKILGHSDRCWSPSCSGPN 973 +ALK + L CT EC++LGHSDRCW P N Sbjct: 910 CDMSVREALKMKTTSTKSQPLEQEPEECVNCTDECRVLGHSDRCWMPQFPAAN 962 >gi|157426847 protocadherin 19 isoform a [Homo sapiens] Length = 1101 Score = 471 bits (1212), Expect = e-132 Identities = 288/773 (37%), Positives = 432/773 (55%), Gaps = 75/773 (9%) Query: 15 LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLH-----MKVSGDTSFRLMKQF 69 L L ++ W + A ++YS EE GTVI +A+D + ++FR++ Sbjct: 9 LLLLAILWTQAAALIN-LKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67 Query: 70 NSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVN 129 L+ + G L V +DR+ LC Q+P+C+++ +V+S S E + ++VE++D+N Sbjct: 68 APHLVDINPSSG-LLVTKQKIDRDLLCRQSPKCIISLEVMSSSME---ICVIKVEIKDLN 123 Query: 130 DHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRA 189 D+AP FP AQI +E+SE A+ GTRIPL+ D D G+ G+QT L P+ F +E++TR Sbjct: 124 DNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELT-PNELFGLEIKTRG 182 Query: 190 DGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGA 249 DG++ A+LV+ + LDRE+Q+ YS + A DGG PPR T LS++V D+ND++P F + Sbjct: 183 DGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSEST 242 Query: 250 VAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLA 309 A V + E++P + ++ L+A+DPDEG NG VV++F R LF++DP SG +T+ Sbjct: 243 YA-VSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVT 301 Query: 310 GPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSP 369 G +DYE YELDV+A+D GP A CKV V + D NDN P I + Sbjct: 302 GALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINL------------- 348 Query: 370 FAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRC 429 + + L S+P G ++ALV SDRDSG NG+V+C Sbjct: 349 ---LSVNSELVEVSESAPPG-------------------YVIALVRVSDRDSGLNGRVQC 386 Query: 430 ALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGD 489 L G+ FRLQ Y ++ LDRE+ +YNLT+ A D G P L++ + +TV + D Sbjct: 387 RLLGNVPFRLQ-EYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITD 445 Query: 490 ENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVS 549 ENDN P F++P Y+V V+ENN PGAYL +V+ARD DLG NG V+Y+++ ++V V Sbjct: 446 ENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQV--RDMPVF 503 Query: 550 TYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVL 609 TYVS++P +G IYALRSF++E + + ++ A DGG P L S+A V+V +LD ND+ PV+ Sbjct: 504 TYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVI 563 Query: 610 VHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTG 669 P NG+ EV +P + +V V+A D DEG NG + +++ + + R F I + G Sbjct: 564 TAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGD-RGFFEIDQVNG 622 Query: 670 EILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPER 729 E+ T + + ++V D G+ L+ +A V ++ PA A Sbjct: 623 EVRTTRTFGESSKSS-YELIVVAHDHGKTSLSASALVLIYLS------PALDAQES---- 671 Query: 730 SRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVR 782 GSV + LI II L +L +I +A C R KE+R Sbjct: 672 ----------MGSV---NLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIR 711 Score = 51.6 bits (122), Expect = 4e-06 Identities = 32/88 (36%), Positives = 42/88 (47%), Gaps = 16/88 (18%) Query: 907 REAEKFSGKDSGKGDSDFNDSDSDISG----DALKKDLIN------------HMQSGLWA 950 ++ E S KDSG +SD DS+ D+ D D++N H Q+ + Sbjct: 850 KDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFH 909 Query: 951 CTAECKILGHSDRCWSPSCSGPNAHPSP 978 C EC+ILGHSDRCW P P SP Sbjct: 910 CREECRILGHSDRCWMPRNPMPIRSKSP 937 >gi|157426845 protocadherin 19 isoform b [Homo sapiens] Length = 1100 Score = 471 bits (1212), Expect = e-132 Identities = 288/773 (37%), Positives = 432/773 (55%), Gaps = 75/773 (9%) Query: 15 LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLH-----MKVSGDTSFRLMKQF 69 L L ++ W + A ++YS EE GTVI +A+D + ++FR++ Sbjct: 9 LLLLAILWTQAAALIN-LKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67 Query: 70 NSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVN 129 L+ + G L V +DR+ LC Q+P+C+++ +V+S S E + ++VE++D+N Sbjct: 68 APHLVDINPSSG-LLVTKQKIDRDLLCRQSPKCIISLEVMSSSME---ICVIKVEIKDLN 123 Query: 130 DHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRA 189 D+AP FP AQI +E+SE A+ GTRIPL+ D D G+ G+QT L P+ F +E++TR Sbjct: 124 DNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELT-PNELFGLEIKTRG 182 Query: 190 DGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGA 249 DG++ A+LV+ + LDRE+Q+ YS + A DGG PPR T LS++V D+ND++P F + Sbjct: 183 DGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSEST 242 Query: 250 VAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLA 309 A V + E++P + ++ L+A+DPDEG NG VV++F R LF++DP SG +T+ Sbjct: 243 YA-VSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVT 301 Query: 310 GPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSP 369 G +DYE YELDV+A+D GP A CKV V + D NDN P I + Sbjct: 302 GALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINL------------- 348 Query: 370 FAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRC 429 + + L S+P G ++ALV SDRDSG NG+V+C Sbjct: 349 ---LSVNSELVEVSESAPPG-------------------YVIALVRVSDRDSGLNGRVQC 386 Query: 430 ALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGD 489 L G+ FRLQ Y ++ LDRE+ +YNLT+ A D G P L++ + +TV + D Sbjct: 387 RLLGNVPFRLQ-EYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITD 445 Query: 490 ENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVS 549 ENDN P F++P Y+V V+ENN PGAYL +V+ARD DLG NG V+Y+++ ++V V Sbjct: 446 ENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQV--RDMPVF 503 Query: 550 TYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVL 609 TYVS++P +G IYALRSF++E + + ++ A DGG P L S+A V+V +LD ND+ PV+ Sbjct: 504 TYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVI 563 Query: 610 VHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTG 669 P NG+ EV +P + +V V+A D DEG NG + +++ + + R F I + G Sbjct: 564 TAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGD-RGFFEIDQVNG 622 Query: 670 EILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPER 729 E+ T + + ++V D G+ L+ +A V ++ PA A Sbjct: 623 EVRTTRTFGESSKSS-YELIVVAHDHGKTSLSASALVLIYLS------PALDAQES---- 671 Query: 730 SRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVR 782 GSV + LI II L +L +I +A C R KE+R Sbjct: 672 ----------MGSV---NLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIR 711 Score = 53.5 bits (127), Expect = 1e-06 Identities = 33/98 (33%), Positives = 46/98 (46%), Gaps = 16/98 (16%) Query: 897 KGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISG----DALKKDLIN---------- 942 + H + + ++ E S KDSG +SD DS+ D+ D D++N Sbjct: 839 RAHLIKSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQM 898 Query: 943 --HMQSGLWACTAECKILGHSDRCWSPSCSGPNAHPSP 978 H Q+ + C EC+ILGHSDRCW P P SP Sbjct: 899 PDHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSP 936 >gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precursor [Homo sapiens] Length = 1007 Score = 448 bits (1153), Expect = e-125 Identities = 271/704 (38%), Positives = 391/704 (55%), Gaps = 53/704 (7%) Query: 12 LFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVS----GDTSFRLMK 67 L PL L L + A S+ +RYS EE APG ++G +A L +++ G + Sbjct: 25 LLPLLLLLLLLLPGPAASQ-LRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRINHLG 83 Query: 68 QFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRD 127 + L + G L V + +DRE LC Q P+C+L+ +V++ + + VEVE+ D Sbjct: 84 APSPRYLELDLTSGALFVNER-IDREALCEQRPRCLLSLEVLAHNP--VAVSAVEVEILD 140 Query: 128 VNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQT 187 +ND++PRFPR ++VSE A G R +E D DVGAN +QT L+ P F ++L+ Sbjct: 141 INDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELS-PSEHFELDLKP 199 Query: 188 RADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247 + ++ +LVL + LDRE A + L L A DGG P RS TA +SVRVLD ND+SPAF Q Sbjct: 200 LQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQ 259 Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLT 307 V+L ED+P G+L++ L+A+DPDEG NG++ ++ + T R+LF +D +G + Sbjct: 260 STY-RVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVR 318 Query: 308 LAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPAT 367 + G +DYE +Y++ V+A DRGP P A CKV+V I DVNDNAP++ +T L +P Sbjct: 319 VIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSP----- 373 Query: 368 SPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQV 427 VPE A ++VA++S +D+DSG N +V Sbjct: 374 ---------------------------------VPENATPNTIVAVLSVNDQDSGPNRKV 400 Query: 428 RCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRV 487 L FRL + SY +V + LDRER+A YN+T+ A D G P L ++R V + Sbjct: 401 SLGLEATLPFRLN-GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEI 459 Query: 488 GDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGA 547 D NDN P F Y + ++ENN PG L TV A D D N +VTY LLE E+ G Sbjct: 460 SDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREI--QGLP 517 Query: 548 VSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAP 607 V++YVS++ A+G++YA+ SFDYE R+ V ++A D GSP LSS+ V V+D NDHAP Sbjct: 518 VTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAP 577 Query: 608 VLVHPAPANGSLEVAVPGRTA-KDTVVARVQARDADEGANGELAFELQQQEPREAFAIGR 666 +++P N S + RTA +V +V A D+D G N L + L Q + F + Sbjct: 578 HILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVEL 637 Query: 667 RTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVV 710 TGEI T + E G F +V+ D G P L+ + ++ V Sbjct: 638 HTGEIRTTRKMGDE-SGSTFNLTVVVRDNGEPSLSASVAITVAV 680 Score = 138 bits (347), Expect = 3e-32 Identities = 157/603 (26%), Positives = 254/603 (42%), Gaps = 91/603 (15%) Query: 137 RAQIPVEVSEGAAVGT---RIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQ 193 R +P E + GA VG + LE+ +G L+ L P SP +EL + Sbjct: 45 RYSVPEEQAPGALVGNVARALGLEL---RRLGPGCLRINHLGAP-SPRYLELDLTSGA-- 98 Query: 194 CADLVLLQELDRES------QAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247 L + + +DRE+ + SLE++A + A +A+ V +LD ND+SP FP+ Sbjct: 99 ---LFVNERIDREALCEQRPRCLLSLEVLAHNP-----VAVSAVEVEILDINDNSPRFPR 150 Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRL----FRLDPRS 303 +++++E G+ A DPD G N + +P E L + + + Sbjct: 151 PNY-QLQVSESVAPGARFHIESAQDPDVGANSVQTYEL---SPSEHFELDLKPLQENSKV 206 Query: 304 GRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPG 363 L L +D E+ + L + A D G R+ T ++ VR+ D NDN+P Sbjct: 207 LELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSP----------- 255 Query: 364 APATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGA 423 F + L SP G +LV ++ SD D G+ Sbjct: 256 -----AFDQSTYRVQLR---EDSPPG-------------------TLVVKLNASDPDEGS 288 Query: 424 NGQVRCALYGHEHFRLQPAY---AGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480 NG++R +L + R + + A + V LD E + Y + + A DRG P+ Sbjct: 289 NGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGH 348 Query: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540 V + D NDNAP V EN P +A ++ D+D G N +V+ L Sbjct: 349 CKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATL 408 Query: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600 R G ++Y V +G + D E + ++ + A+DGG PQL+S ++V + Sbjct: 409 PFRLNGFGNSYTLV--VSGPL------DRERVAVYNITVTATDGGIPQLTSLRTLKVEIS 460 Query: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--- 657 D ND+ P + + + E +PG ++ VQA D DE N E+ + L ++E Sbjct: 461 DINDNPPSFLEDSYSIYIQENNLPG-----VLLCTVQATDPDEKENAEVTYSLLEREIQG 515 Query: 658 -PREAF-AIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGG 715 P ++ +I +G + E R F + D G PPL++T T + V Sbjct: 516 LPVTSYVSINSASGSLYAVNSFDYEK-FREFFVTVEAQDKGSPPLSSTVTANVYVVDMND 574 Query: 716 RGP 718 P Sbjct: 575 HAP 577 Score = 111 bits (277), Expect = 4e-24 Identities = 102/371 (27%), Positives = 151/371 (40%), Gaps = 41/371 (11%) Query: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180 V V++ DVND+AP + V E A T + + D+D G N ++ L E P Sbjct: 351 VLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGL-EATLP 409 Query: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240 FR+ LV+ LDRE A Y++ + A DGG P ++ L V + D ND Sbjct: 410 FRLN-----GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDIND 464 Query: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPP--EARRLFR 298 + P+F + + + + + E+ G LL + A DPDE N +V ++ R Sbjct: 465 NPPSFLEDSYS-IYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVS 523 Query: 299 LDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITP 358 ++ SG L DYE+ + + V AQD+G P ++T V + D+ND+AP I Sbjct: 524 INSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYP- 582 Query: 359 LAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSD 418 T + A +VP A LV V D Sbjct: 583 -------------------------------TSTNSSAAFEMVPRTAPAGYLVTKVIAMD 611 Query: 419 RDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLR 478 DSG N + L L + + T + E + +NLT+V D G P L Sbjct: 612 SDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLS 671 Query: 479 TVRPYTVRVGD 489 TV V D Sbjct: 672 ASVAITVAVVD 682 Score = 46.2 bits (108), Expect = 2e-04 Identities = 43/161 (26%), Positives = 67/161 (41%), Gaps = 39/161 (24%) Query: 106 FDVVSFSQEQFRLVHVEVEVRD------------------VNDHAPRFPRAQIPVEVSEG 147 + V SF E+FR V VE +D +NDHAP P + Sbjct: 532 YAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHI---LYPTSTNSS 588 Query: 148 AA---------VGTRIPLEVPVDEDVGANGLQTVRLAEPH--SPFRVELQTRADGAQCAD 196 AA G + + +D D G N LA+ F+VEL T + Sbjct: 589 AAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHT-------GE 641 Query: 197 LVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLD 237 + +++ ES + ++L +V +D G P SA+ A++V V+D Sbjct: 642 IRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682 >gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precursor [Homo sapiens] Length = 884 Score = 448 bits (1153), Expect = e-125 Identities = 271/704 (38%), Positives = 391/704 (55%), Gaps = 53/704 (7%) Query: 12 LFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVS----GDTSFRLMK 67 L PL L L + A S+ +RYS EE APG ++G +A L +++ G + Sbjct: 25 LLPLLLLLLLLLPGPAASQ-LRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRINHLG 83 Query: 68 QFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRD 127 + L + G L V + +DRE LC Q P+C+L+ +V++ + + VEVE+ D Sbjct: 84 APSPRYLELDLTSGALFVNER-IDREALCEQRPRCLLSLEVLAHNP--VAVSAVEVEILD 140 Query: 128 VNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQT 187 +ND++PRFPR ++VSE A G R +E D DVGAN +QT L+ P F ++L+ Sbjct: 141 INDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELS-PSEHFELDLKP 199 Query: 188 RADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247 + ++ +LVL + LDRE A + L L A DGG P RS TA +SVRVLD ND+SPAF Q Sbjct: 200 LQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQ 259 Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLT 307 V+L ED+P G+L++ L+A+DPDEG NG++ ++ + T R+LF +D +G + Sbjct: 260 STY-RVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVR 318 Query: 308 LAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPAT 367 + G +DYE +Y++ V+A DRGP P A CKV+V I DVNDNAP++ +T L +P Sbjct: 319 VIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSP----- 373 Query: 368 SPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQV 427 VPE A ++VA++S +D+DSG N +V Sbjct: 374 ---------------------------------VPENATPNTIVAVLSVNDQDSGPNRKV 400 Query: 428 RCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRV 487 L FRL + SY +V + LDRER+A YN+T+ A D G P L ++R V + Sbjct: 401 SLGLEATLPFRLN-GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEI 459 Query: 488 GDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGA 547 D NDN P F Y + ++ENN PG L TV A D D N +VTY LLE E+ G Sbjct: 460 SDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREI--QGLP 517 Query: 548 VSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAP 607 V++YVS++ A+G++YA+ SFDYE R+ V ++A D GSP LSS+ V V+D NDHAP Sbjct: 518 VTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAP 577 Query: 608 VLVHPAPANGSLEVAVPGRTA-KDTVVARVQARDADEGANGELAFELQQQEPREAFAIGR 666 +++P N S + RTA +V +V A D+D G N L + L Q + F + Sbjct: 578 HILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVEL 637 Query: 667 RTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVV 710 TGEI T + E G F +V+ D G P L+ + ++ V Sbjct: 638 HTGEIRTTRKMGDE-SGSTFNLTVVVRDNGEPSLSASVAITVAV 680 Score = 138 bits (347), Expect = 3e-32 Identities = 157/603 (26%), Positives = 254/603 (42%), Gaps = 91/603 (15%) Query: 137 RAQIPVEVSEGAAVGT---RIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQ 193 R +P E + GA VG + LE+ +G L+ L P SP +EL + Sbjct: 45 RYSVPEEQAPGALVGNVARALGLEL---RRLGPGCLRINHLGAP-SPRYLELDLTSGA-- 98 Query: 194 CADLVLLQELDRES------QAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247 L + + +DRE+ + SLE++A + A +A+ V +LD ND+SP FP+ Sbjct: 99 ---LFVNERIDREALCEQRPRCLLSLEVLAHNP-----VAVSAVEVEILDINDNSPRFPR 150 Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRL----FRLDPRS 303 +++++E G+ A DPD G N + +P E L + + + Sbjct: 151 PNY-QLQVSESVAPGARFHIESAQDPDVGANSVQTYEL---SPSEHFELDLKPLQENSKV 206 Query: 304 GRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPG 363 L L +D E+ + L + A D G R+ T ++ VR+ D NDN+P Sbjct: 207 LELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSP----------- 255 Query: 364 APATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGA 423 F + L SP G +LV ++ SD D G+ Sbjct: 256 -----AFDQSTYRVQLR---EDSPPG-------------------TLVVKLNASDPDEGS 288 Query: 424 NGQVRCALYGHEHFRLQPAY---AGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480 NG++R +L + R + + A + V LD E + Y + + A DRG P+ Sbjct: 289 NGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGH 348 Query: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540 V + D NDNAP V EN P +A ++ D+D G N +V+ L Sbjct: 349 CKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATL 408 Query: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600 R G ++Y V +G + D E + ++ + A+DGG PQL+S ++V + Sbjct: 409 PFRLNGFGNSYTLV--VSGPL------DRERVAVYNITVTATDGGIPQLTSLRTLKVEIS 460 Query: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--- 657 D ND+ P + + + E +PG ++ VQA D DE N E+ + L ++E Sbjct: 461 DINDNPPSFLEDSYSIYIQENNLPG-----VLLCTVQATDPDEKENAEVTYSLLEREIQG 515 Query: 658 -PREAF-AIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGG 715 P ++ +I +G + E R F + D G PPL++T T + V Sbjct: 516 LPVTSYVSINSASGSLYAVNSFDYEK-FREFFVTVEAQDKGSPPLSSTVTANVYVVDMND 574 Query: 716 RGP 718 P Sbjct: 575 HAP 577 Score = 111 bits (277), Expect = 4e-24 Identities = 102/371 (27%), Positives = 151/371 (40%), Gaps = 41/371 (11%) Query: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180 V V++ DVND+AP + V E A T + + D+D G N ++ L E P Sbjct: 351 VLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGL-EATLP 409 Query: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240 FR+ LV+ LDRE A Y++ + A DGG P ++ L V + D ND Sbjct: 410 FRLN-----GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDIND 464 Query: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPP--EARRLFR 298 + P+F + + + + + E+ G LL + A DPDE N +V ++ R Sbjct: 465 NPPSFLEDSYS-IYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVS 523 Query: 299 LDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITP 358 ++ SG L DYE+ + + V AQD+G P ++T V + D+ND+AP I Sbjct: 524 INSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYP- 582 Query: 359 LAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSD 418 T + A +VP A LV V D Sbjct: 583 -------------------------------TSTNSSAAFEMVPRTAPAGYLVTKVIAMD 611 Query: 419 RDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLR 478 DSG N + L L + + T + E + +NLT+V D G P L Sbjct: 612 SDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLS 671 Query: 479 TVRPYTVRVGD 489 TV V D Sbjct: 672 ASVAITVAVVD 682 Score = 46.2 bits (108), Expect = 2e-04 Identities = 43/161 (26%), Positives = 67/161 (41%), Gaps = 39/161 (24%) Query: 106 FDVVSFSQEQFRLVHVEVEVRD------------------VNDHAPRFPRAQIPVEVSEG 147 + V SF E+FR V VE +D +NDHAP P + Sbjct: 532 YAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHI---LYPTSTNSS 588 Query: 148 AA---------VGTRIPLEVPVDEDVGANGLQTVRLAEPH--SPFRVELQTRADGAQCAD 196 AA G + + +D D G N LA+ F+VEL T + Sbjct: 589 AAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHT-------GE 641 Query: 197 LVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLD 237 + +++ ES + ++L +V +D G P SA+ A++V V+D Sbjct: 642 IRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682 >gi|7706113 protocadherin 12 precursor [Homo sapiens] Length = 1184 Score = 446 bits (1146), Expect = e-125 Identities = 280/787 (35%), Positives = 425/787 (54%), Gaps = 104/787 (13%) Query: 31 TVRYSTFEEDAPGTVIGTLAEDL---HMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGD 87 TV+Y EE GTVIG L+++L + +F++++ + ++V +G L+ G Sbjct: 31 TVKYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQLPQALPIQVDSEEGLLSTGR 90 Query: 88 AGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEG 147 LDRE+LC Q C+++FDV++ L+HVE++V D+NDH PRFP+ + +E+SE Sbjct: 91 R-LDREQLCRQWDPCLVSFDVLATGD--LALIHVEIQVLDINDHQPRFPKGEQELEISES 147 Query: 148 AAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRES 207 A++ TRIPL+ +D D G N L T L+ P F +++ D + A+L++++ELDRE Sbjct: 148 ASLRTRIPLDRALDPDTGPNTLHTYTLS-PSEHFALDVIVGPDETKHAELIVVKELDREI 206 Query: 208 QAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLD 267 + + L L A D G PP+S T+ + V VLD+ND+SPAF + ++A +E+ EDA G+LL+ Sbjct: 207 HSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLA-LEIQEDAAPGTLLIK 265 Query: 268 LDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQ 327 L A DPD+GPNG+V F PPE F +D ++G++ L P+DYE+ YE+DV+A+ Sbjct: 266 LTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQAR 325 Query: 328 DRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSP 387 D GP P A CKV++++ DVNDN P I +T + P Sbjct: 326 DLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQP------------------------- 360 Query: 388 AGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGH-EHFRLQPAYAGS 446 SLV E ++S +ALV D DSG NG V C L HFRL+ + Sbjct: 361 -----------SLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGNT 409 Query: 447 YLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSV 506 Y+++T A+LDRE+ +Y LTL+A+D+G PL + ++++ D NDNAP+F + YEVS Sbjct: 410 YMLLTNATLDREQWPKYTLTLLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVST 469 Query: 507 RENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRS 566 RENN P +L T+ A D DLG NG+V+YR+ ++ V V++D TG + A RS Sbjct: 470 RENNLPSLHLITIKAHDADLGINGKVSYRIQDSPVAH-------LVAIDSNTGEVTAQRS 522 Query: 567 FDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANG--SLEVAVP 624 +YE + + ++ A D G P L+SS V V +LD ND+AP +V P ++G SL V V Sbjct: 523 LNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVN 582 Query: 625 GRT---------------------------AKDTVVARVQARDADEGANGELAFELQQQE 657 T ++ ++ + ARDAD GANGE + ++ Sbjct: 583 ASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIVARDADSGANGEPLYSIRSGN 642 Query: 658 PREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTA--TVSFVVTAGGG 715 F + TG++ + + G + +V+ D G PPL T A V FV + Sbjct: 643 EAHLFILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFVTSVDHL 702 Query: 716 RGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775 R + +R PG+ +S S+L +I + VL G L+LA ++I C Sbjct: 703 R-----------DSARKPGA---LSMSML----TVICLAVLLGIFGLILALFMSI---CR 741 Query: 776 RRKKEVR 782 KK+ R Sbjct: 742 TEKKDNR 748 >gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precursor [Homo sapiens] Length = 871 Score = 439 bits (1130), Expect = e-123 Identities = 271/748 (36%), Positives = 399/748 (53%), Gaps = 64/748 (8%) Query: 32 VRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMK--QFNSSLLRVREGDGQLTVGDAG 89 +RY EE GT +G +A+D + ++ RL + N RV G L + + Sbjct: 31 IRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNP- 89 Query: 90 LDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAA 149 +DRE LCG + C++ + V+ + + EVE+ DVNDHAPRFPR Q+ +E+ E A Sbjct: 90 IDREALCGLSASCIVPLEFVT--EGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAP 147 Query: 150 VGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQA 209 G R PLE D DVG+N + + RL+ + F ++++ R+DG+ +L+L + LDRE Q+ Sbjct: 148 PGQRFPLEKAQDADVGSNSISSYRLSS-NEHFALDVKKRSDGSLVPELLLEKPLDREKQS 206 Query: 210 AYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLD 269 Y L L A DGG PPRS TA L V VLD ND++PAF Q + + + E AP G +L+ L+ Sbjct: 207 DYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY-RISVLESAPAGMVLIQLN 265 Query: 270 AADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDR 329 A+DPD GP+G+V F F TP R LF L P +G+LTL GP+D+E ++ YE DVRA+D Sbjct: 266 ASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDG 325 Query: 330 GPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAG 389 G C + V + DVNDNAP I +T + LG Sbjct: 326 GSPAMEQHCSLRVDLLDVNDNAPYITVT-------------------SELG--------- 357 Query: 390 AGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLV 449 +PE A ++VAL+S D DSG+NG V + H F L+ A+ + + Sbjct: 358 ----------TLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSL 407 Query: 450 VTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVREN 509 VTA LDRE + Y++ + A D G PPL T R + + D NDN P F + +EV V EN Sbjct: 408 VTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPEN 467 Query: 510 NPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDY 569 N PG L ++AA D D G N ++Y LLE + S+++S++P TGA++A RSFDY Sbjct: 468 NRPGDLLCSLAASDPDSGLNALISYSLLEPR--NRDVSASSFISLNPQTGAVHATRSFDY 525 Query: 570 ETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSL-EVAVPGRTA 628 E + L +QA D G+P LSS+ V++ VLD ND+AP ++ P GSL A+P Sbjct: 526 EQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVG 585 Query: 629 KDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRA 688 ++ +V A D D G N ++++L + FA+ R GE+ + + P + + Sbjct: 586 AGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQ--KL 643 Query: 689 LLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDT 748 ++V+ D G PPL+T+ T+ +V+ P P S R SRL Sbjct: 644 VIVVKDSGSPPLSTSVTL--LVSLEEDTHPVVPDLRES-SAPREGESRL----------- 689 Query: 749 PLIVIIVLAGSCTLLLAAIIAIATTCNR 776 L + + L C + + +A+ + C R Sbjct: 690 TLYLAVSLVAICFVSFGSFVALLSKCLR 717 >gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precursor [Homo sapiens] Length = 938 Score = 439 bits (1130), Expect = e-123 Identities = 271/748 (36%), Positives = 399/748 (53%), Gaps = 64/748 (8%) Query: 32 VRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMK--QFNSSLLRVREGDGQLTVGDAG 89 +RY EE GT +G +A+D + ++ RL + N RV G L + + Sbjct: 31 IRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNP- 89 Query: 90 LDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAA 149 +DRE LCG + C++ + V+ + + EVE+ DVNDHAPRFPR Q+ +E+ E A Sbjct: 90 IDREALCGLSASCIVPLEFVT--EGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAP 147 Query: 150 VGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQA 209 G R PLE D DVG+N + + RL+ + F ++++ R+DG+ +L+L + LDRE Q+ Sbjct: 148 PGQRFPLEKAQDADVGSNSISSYRLSS-NEHFALDVKKRSDGSLVPELLLEKPLDREKQS 206 Query: 210 AYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLD 269 Y L L A DGG PPRS TA L V VLD ND++PAF Q + + + E AP G +L+ L+ Sbjct: 207 DYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY-RISVLESAPAGMVLIQLN 265 Query: 270 AADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDR 329 A+DPD GP+G+V F F TP R LF L P +G+LTL GP+D+E ++ YE DVRA+D Sbjct: 266 ASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDG 325 Query: 330 GPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAG 389 G C + V + DVNDNAP I +T + LG Sbjct: 326 GSPAMEQHCSLRVDLLDVNDNAPYITVT-------------------SELG--------- 357 Query: 390 AGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLV 449 +PE A ++VAL+S D DSG+NG V + H F L+ A+ + + Sbjct: 358 ----------TLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSL 407 Query: 450 VTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVREN 509 VTA LDRE + Y++ + A D G PPL T R + + D NDN P F + +EV V EN Sbjct: 408 VTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPEN 467 Query: 510 NPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDY 569 N PG L ++AA D D G N ++Y LLE + S+++S++P TGA++A RSFDY Sbjct: 468 NRPGDLLCSLAASDPDSGLNALISYSLLEPR--NRDVSASSFISLNPQTGAVHATRSFDY 525 Query: 570 ETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSL-EVAVPGRTA 628 E + L +QA D G+P LSS+ V++ VLD ND+AP ++ P GSL A+P Sbjct: 526 EQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVG 585 Query: 629 KDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRA 688 ++ +V A D D G N ++++L + FA+ R GE+ + + P + + Sbjct: 586 AGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQ--KL 643 Query: 689 LLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDT 748 ++V+ D G PPL+T+ T+ +V+ P P S R SRL Sbjct: 644 VIVVKDSGSPPLSTSVTL--LVSLEEDTHPVVPDLRES-SAPREGESRL----------- 689 Query: 749 PLIVIIVLAGSCTLLLAAIIAIATTCNR 776 L + + L C + + +A+ + C R Sbjct: 690 TLYLAVSLVAICFVSFGSFVALLSKCLR 717 >gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo sapiens] Length = 807 Score = 439 bits (1129), Expect = e-123 Identities = 298/851 (35%), Positives = 442/851 (51%), Gaps = 87/851 (10%) Query: 14 PLQLFSLCWVLSVAQSKT----VRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMK 67 P QL L W+L +A +T + YS EE GT +G +A+DL ++++ FR+ Sbjct: 11 PRQL--LLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVAS 68 Query: 68 QFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRD 127 + + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ HVEV+VRD Sbjct: 69 KRHGDLLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVFHVEVKVRD 125 Query: 128 VNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQT 187 +ND+ P FP ++ + ++E TR PL+ D D+G N T RL +P+ F ++ Q Sbjct: 126 INDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRL-DPNDYFTLDAQN 184 Query: 188 RADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247 + LVL + LDRE +SL L A DGG+P + T L + +LD ND++P F Q Sbjct: 185 SLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQ 244 Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLT 307 +V +V + E+A G+L++ L+A DPD+G NGD+V++F P F ++P +G + Sbjct: 245 -SVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIR 303 Query: 308 LAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPAT 367 G +D+E + YE+ V A D+G P A C ++V + DVNDNAP++ IT L+ P T Sbjct: 304 TKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDT 363 Query: 368 SPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQV 427 P A ++AL+S SDRDSG+NGQV Sbjct: 364 QPSA--------------------------------------IIALISVSDRDSGSNGQV 385 Query: 428 RCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRV 487 C L H F+L Y Y +V ++LDRE ++ Y L + A D G+P L +V V Sbjct: 386 TCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGV 445 Query: 488 GDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGA 547 D NDNAP F +P Y V V+ENNPPG ++ TV+A+D D N V+Y L+E VG A Sbjct: 446 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGER--A 503 Query: 548 VSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAP 607 +S+YVSV +G +YAL+ D+E L L ++ A D G P L S+ +QV VLD+ND+AP Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAP 563 Query: 608 VLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREAFA 663 L+ P A G++ +P VVA+V+A DAD G N L++ELQ R F Sbjct: 564 ALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFR 623 Query: 664 IGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPAS 723 +G TGEI T L E R L+++ D G P LT TATV + G AP + Sbjct: 624 VGLYTGEISTTRPL-DEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESG----QAPQA 678 Query: 724 AGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRK 783 + SR +G +++ + LI I + A S L+L ++ A C+ E Sbjct: 679 S-----SRASAGAVGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSAPPTE--- 729 Query: 784 GGALREERPGAAGGGASAPGSPEEAARG---AGPRPNMFDVLTFPGTGKAPFGSPAADAP 840 GA +P A+ S + R +G P+ D++ F SP+ Sbjct: 730 -GACAPGKPTLVCSSAAGSWSYSQQRRPRVCSGEGPHKTDLMAF---------SPSL--- 776 Query: 841 PPAVAAAEVPG 851 PP + +AE G Sbjct: 777 PPCLGSAEGTG 787 >gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo sapiens] Length = 950 Score = 439 bits (1129), Expect = e-123 Identities = 298/851 (35%), Positives = 442/851 (51%), Gaps = 87/851 (10%) Query: 14 PLQLFSLCWVLSVAQSKT----VRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMK 67 P QL L W+L +A +T + YS EE GT +G +A+DL ++++ FR+ Sbjct: 11 PRQL--LLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVAS 68 Query: 68 QFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRD 127 + + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ HVEV+VRD Sbjct: 69 KRHGDLLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVFHVEVKVRD 125 Query: 128 VNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQT 187 +ND+ P FP ++ + ++E TR PL+ D D+G N T RL +P+ F ++ Q Sbjct: 126 INDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRL-DPNDYFTLDAQN 184 Query: 188 RADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247 + LVL + LDRE +SL L A DGG+P + T L + +LD ND++P F Q Sbjct: 185 SLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQ 244 Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLT 307 +V +V + E+A G+L++ L+A DPD+G NGD+V++F P F ++P +G + Sbjct: 245 -SVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIR 303 Query: 308 LAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPAT 367 G +D+E + YE+ V A D+G P A C ++V + DVNDNAP++ IT L+ P T Sbjct: 304 TKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDT 363 Query: 368 SPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQV 427 P A ++AL+S SDRDSG+NGQV Sbjct: 364 QPSA--------------------------------------IIALISVSDRDSGSNGQV 385 Query: 428 RCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRV 487 C L H F+L Y Y +V ++LDRE ++ Y L + A D G+P L +V V Sbjct: 386 TCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGV 445 Query: 488 GDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGA 547 D NDNAP F +P Y V V+ENNPPG ++ TV+A+D D N V+Y L+E VG A Sbjct: 446 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGER--A 503 Query: 548 VSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAP 607 +S+YVSV +G +YAL+ D+E L L ++ A D G P L S+ +QV VLD+ND+AP Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAP 563 Query: 608 VLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREAFA 663 L+ P A G++ +P VVA+V+A DAD G N L++ELQ R F Sbjct: 564 ALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFR 623 Query: 664 IGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPAS 723 +G TGEI T L E R L+++ D G P LT TATV + G AP + Sbjct: 624 VGLYTGEISTTRPL-DEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESG----QAPQA 678 Query: 724 AGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRK 783 + SR +G +++ + LI I + A S L+L ++ A C+ E Sbjct: 679 S-----SRASAGAVGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSAPPTE--- 729 Query: 784 GGALREERPGAAGGGASAPGSPEEAARG---AGPRPNMFDVLTFPGTGKAPFGSPAADAP 840 GA +P A+ S + R +G P+ D++ F SP+ Sbjct: 730 -GACAPGKPTLVCSSAAGSWSYSQQRRPRVCSGEGPHKTDLMAF---------SPSL--- 776 Query: 841 PPAVAAAEVPG 851 PP + +AE G Sbjct: 777 PPCLGSAEGTG 787 >gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo sapiens] Length = 814 Score = 438 bits (1126), Expect = e-122 Identities = 292/818 (35%), Positives = 426/818 (52%), Gaps = 74/818 (9%) Query: 8 GSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRL 65 GS L L L W + Q + YS EE GT +G +A+DL ++++ FR+ Sbjct: 10 GSWRLLLLLLLLAAWKVGSGQ---LHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRV 66 Query: 66 MKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEV 125 + + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ HV+VEV Sbjct: 67 ASKRHRDLLEVSLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVFHVDVEV 123 Query: 126 RDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVEL 185 +DVND+ P F + VSE +R PLE D DVGAN + T RL+ H F +++ Sbjct: 124 KDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSS-HDYFMLDV 182 Query: 186 QTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAF 245 ++ D + +LVL + LDRE A+ L L A DGG+P + T L V VLD ND++P F Sbjct: 183 NSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTF 242 Query: 246 PQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGR 305 Q EV + E+A G+ ++ L+A+DPDEG NG + ++F + F +D +G Sbjct: 243 EQSEY-EVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGE 301 Query: 306 LTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAP 365 + + G +D+E+++ Y++ + A D+G P A C V+VRI D NDN P+IA+T L+ P Sbjct: 302 IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLP--- 358 Query: 366 ATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANG 425 V E A +++AL+S +D DSGANG Sbjct: 359 -----------------------------------VREDAQFGTVIALISVNDLDSGANG 383 Query: 426 QVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTV 485 QV C+L H F+L + Y +V ++LDRER++ Y L + A D G+P L +V Sbjct: 384 QVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSV 443 Query: 486 RVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAG 545 V D NDNAP F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E VG Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER- 502 Query: 546 GAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDH 605 ++S+Y+SV +G +YAL+ D+E L L ++ A D G P L S+ +QV VLD+ND+ Sbjct: 503 -SLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDN 561 Query: 606 APVLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQ--QQEPREA 661 AP L+ P G+ VP VVA+V+A DAD G N L++ELQ PR Sbjct: 562 APALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIP 621 Query: 662 FAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAP 721 F +G TGEI T L + R R L+++ D G P LT TATV V G+ P A Sbjct: 622 FRVGLYTGEISTTRVLDEADSPR-HRLLVLVKDHGEPALTATATV-LVSLVESGQAPKA- 678 Query: 722 ASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEV 781 SR LG +++ + LI I + A S L+L ++ A C+ E Sbjct: 679 -------SSRQSAGVLGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSALPTE- 729 Query: 782 RKGGALREERP-----GAAGGGASAPGSPEEAARGAGP 814 G R +P A G + + P+ G GP Sbjct: 730 ---GGCRAGKPTLVCSSAVGSWSYSQQQPQRVCSGEGP 764 >gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens] Length = 950 Score = 438 bits (1126), Expect = e-122 Identities = 292/818 (35%), Positives = 426/818 (52%), Gaps = 74/818 (9%) Query: 8 GSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRL 65 GS L L L W + Q + YS EE GT +G +A+DL ++++ FR+ Sbjct: 10 GSWRLLLLLLLLAAWKVGSGQ---LHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRV 66 Query: 66 MKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEV 125 + + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ HV+VEV Sbjct: 67 ASKRHRDLLEVSLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVFHVDVEV 123 Query: 126 RDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVEL 185 +DVND+ P F + VSE +R PLE D DVGAN + T RL+ H F +++ Sbjct: 124 KDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSS-HDYFMLDV 182 Query: 186 QTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAF 245 ++ D + +LVL + LDRE A+ L L A DGG+P + T L V VLD ND++P F Sbjct: 183 NSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTF 242 Query: 246 PQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGR 305 Q EV + E+A G+ ++ L+A+DPDEG NG + ++F + F +D +G Sbjct: 243 EQSEY-EVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGE 301 Query: 306 LTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAP 365 + + G +D+E+++ Y++ + A D+G P A C V+VRI D NDN P+IA+T L+ P Sbjct: 302 IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLP--- 358 Query: 366 ATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANG 425 V E A +++AL+S +D DSGANG Sbjct: 359 -----------------------------------VREDAQFGTVIALISVNDLDSGANG 383 Query: 426 QVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTV 485 QV C+L H F+L + Y +V ++LDRER++ Y L + A D G+P L +V Sbjct: 384 QVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSV 443 Query: 486 RVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAG 545 V D NDNAP F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E VG Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER- 502 Query: 546 GAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDH 605 ++S+Y+SV +G +YAL+ D+E L L ++ A D G P L S+ +QV VLD+ND+ Sbjct: 503 -SLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDN 561 Query: 606 APVLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQ--QQEPREA 661 AP L+ P G+ VP VVA+V+A DAD G N L++ELQ PR Sbjct: 562 APALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIP 621 Query: 662 FAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAP 721 F +G TGEI T L + R R L+++ D G P LT TATV V G+ P A Sbjct: 622 FRVGLYTGEISTTRVLDEADSPR-HRLLVLVKDHGEPALTATATV-LVSLVESGQAPKA- 678 Query: 722 ASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEV 781 SR LG +++ + LI I + A S L+L ++ A C+ E Sbjct: 679 -------SSRQSAGVLGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSALPTE- 729 Query: 782 RKGGALREERP-----GAAGGGASAPGSPEEAARGAGP 814 G R +P A G + + P+ G GP Sbjct: 730 ---GGCRAGKPTLVCSSAVGSWSYSQQQPQRVCSGEGP 764 >gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo sapiens] Length = 824 Score = 426 bits (1095), Expect = e-119 Identities = 273/785 (34%), Positives = 412/785 (52%), Gaps = 83/785 (10%) Query: 29 SKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSLLRVREGDGQLTVG 86 S +RYS EE GT +G +A+DL +++ FR+ + + LL V +G L V Sbjct: 28 SGQLRYSVPEEAKHGTFVGRIAQDLGLELEELVPRLFRVASKRHGDLLEVNLQNGILFV- 86 Query: 87 DAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSE 146 ++ +DRE LCG++ +C + +V+ ++ HVEVEV+D+ND+ P FP + E Sbjct: 87 NSRIDREELCGRSAECSIHVEVIV--DRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPE 144 Query: 147 GAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRE 206 + +R PLE D D+G N L + +L+ F +++Q + ++ LVL + LDRE Sbjct: 145 SRLLDSRFPLEGASDADIGVNALLSYKLSSSEF-FFLDIQANDELSESLSLVLGKSLDRE 203 Query: 207 SQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLL 266 A +L LVA DGG+P + T + ++VLD ND+ P F Q +V +V+L E+ G+L++ Sbjct: 204 ETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQ-SVYKVKLLENTANGTLVV 262 Query: 267 DLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRA 326 L+A+D DEGPN ++V++ G+ + F +DP SG + G +DYE +YE+ V A Sbjct: 263 KLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTA 322 Query: 327 QDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASS 386 D+G + CK+ +++ D+NDN P+++IT L+ P Sbjct: 323 TDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLP------------------------ 358 Query: 387 PAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGS 446 + E A+ +++AL++ SDRDSG NG V C+L H F+L + Sbjct: 359 --------------ISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNY 404 Query: 447 YLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSV 506 Y +V ++LDRE ++ Y L + A D G+P L ++ V D NDNAP F +P Y V V Sbjct: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFV 464 Query: 507 RENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRS 566 +ENNPPG ++ TV+A D D N V+Y L+E VG A+S+YVSV +G +YAL+ Sbjct: 465 KENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGER--ALSSYVSVHAESGKVYALQP 522 Query: 567 FDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP--APANGSLEVAVP 624 D+E + L ++ A D G P L S+ +QV VLD+ND+AP L+ P A G++ VP Sbjct: 523 LDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVP 582 Query: 625 GRTAKDTVVARVQARDADEGANGELAFELQ--QQEPREAFAIGRRTGEILLTGDLSQEPP 682 VVA+V+A DAD G N L++ELQ R F +G TGEI T L + Sbjct: 583 WSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVGLYTGEISTTRALDEADS 642 Query: 683 GRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGS 742 R R L+++ D G P LT TATV V G+ P A + A +G +GS Sbjct: 643 PR-HRLLVLVKDHGEPALTATATV-LVSLVESGQAPKASSRAW-----------VGAAGS 689 Query: 743 --VLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGAS 800 L ++I + A S L+L ++ A C+ E GA Sbjct: 690 EATLVDVNVYLIIAICAVSSLLVLTVLLYTALRCSVPPTE-----------------GAR 732 Query: 801 APGSP 805 APG P Sbjct: 733 APGKP 737 >gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens] Length = 948 Score = 426 bits (1095), Expect = e-119 Identities = 273/785 (34%), Positives = 412/785 (52%), Gaps = 83/785 (10%) Query: 29 SKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSLLRVREGDGQLTVG 86 S +RYS EE GT +G +A+DL +++ FR+ + + LL V +G L V Sbjct: 28 SGQLRYSVPEEAKHGTFVGRIAQDLGLELEELVPRLFRVASKRHGDLLEVNLQNGILFV- 86 Query: 87 DAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSE 146 ++ +DRE LCG++ +C + +V+ ++ HVEVEV+D+ND+ P FP + E Sbjct: 87 NSRIDREELCGRSAECSIHVEVIV--DRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPE 144 Query: 147 GAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRE 206 + +R PLE D D+G N L + +L+ F +++Q + ++ LVL + LDRE Sbjct: 145 SRLLDSRFPLEGASDADIGVNALLSYKLSSSEF-FFLDIQANDELSESLSLVLGKSLDRE 203 Query: 207 SQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLL 266 A +L LVA DGG+P + T + ++VLD ND+ P F Q +V +V+L E+ G+L++ Sbjct: 204 ETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQ-SVYKVKLLENTANGTLVV 262 Query: 267 DLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRA 326 L+A+D DEGPN ++V++ G+ + F +DP SG + G +DYE +YE+ V A Sbjct: 263 KLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTA 322 Query: 327 QDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASS 386 D+G + CK+ +++ D+NDN P+++IT L+ P Sbjct: 323 TDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLP------------------------ 358 Query: 387 PAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGS 446 + E A+ +++AL++ SDRDSG NG V C+L H F+L + Sbjct: 359 --------------ISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNY 404 Query: 447 YLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSV 506 Y +V ++LDRE ++ Y L + A D G+P L ++ V D NDNAP F +P Y V V Sbjct: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFV 464 Query: 507 RENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRS 566 +ENNPPG ++ TV+A D D N V+Y L+E VG A+S+YVSV +G +YAL+ Sbjct: 465 KENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGER--ALSSYVSVHAESGKVYALQP 522 Query: 567 FDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP--APANGSLEVAVP 624 D+E + L ++ A D G P L S+ +QV VLD+ND+AP L+ P A G++ VP Sbjct: 523 LDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVP 582 Query: 625 GRTAKDTVVARVQARDADEGANGELAFELQ--QQEPREAFAIGRRTGEILLTGDLSQEPP 682 VVA+V+A DAD G N L++ELQ R F +G TGEI T L + Sbjct: 583 WSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVGLYTGEISTTRALDEADS 642 Query: 683 GRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGS 742 R R L+++ D G P LT TATV V G+ P A + A +G +GS Sbjct: 643 PR-HRLLVLVKDHGEPALTATATV-LVSLVESGQAPKASSRAW-----------VGAAGS 689 Query: 743 --VLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGAS 800 L ++I + A S L+L ++ A C+ E GA Sbjct: 690 EATLVDVNVYLIIAICAVSSLLVLTVLLYTALRCSVPPTE-----------------GAR 732 Query: 801 APGSP 805 APG P Sbjct: 733 APGKP 737 >gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens] Length = 936 Score = 426 bits (1094), Expect = e-119 Identities = 273/770 (35%), Positives = 410/770 (53%), Gaps = 65/770 (8%) Query: 20 LCWVLSV---AQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSLL 74 L W+L A S + YS EE GT +G +A+DL ++++ FR+ + LL Sbjct: 15 LLWLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGDLL 74 Query: 75 RVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPR 134 V +G L V ++ +DRE LC + +C + +V+ ++ HVEV V+D+ND+ PR Sbjct: 75 EVNLQNGILFV-NSRIDREELCRRRAECSIHLEVIV--DRPLQVFHVEVAVKDINDNPPR 131 Query: 135 FPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQC 194 F R + + + E +R PLE D D+GAN RL P+ F ++++T + Sbjct: 132 FSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRL-NPNEYFDLDVKTNEEETNF 190 Query: 195 ADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVE 254 +LVL + LDRE + L ++A DGG+P + T L + VLDAND++P F + ++ V Sbjct: 191 LELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDK-SIYNVR 249 Query: 255 LAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDY 314 L E+AP G+L++ L+A+D DEG N ++V+ F + + F ++ +G + + G +DY Sbjct: 250 LLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDY 309 Query: 315 ERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAA 374 E ++YE+++ A D+ P + CKV+V++ DVNDN P++AIT L P Sbjct: 310 EDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLP------------ 357 Query: 375 AAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGH 434 V E A +++AL+S SDRDSGANGQV C+L H Sbjct: 358 --------------------------VKEDAPLSTVIALISVSDRDSGANGQVTCSLMPH 391 Query: 435 EHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNA 494 F+L + Y +V ++LDRE ++ Y L + A D G+P L +V V D NDNA Sbjct: 392 VPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNA 451 Query: 495 PLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSV 554 P F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E VG +S+YVSV Sbjct: 452 PAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER--PLSSYVSV 509 Query: 555 DPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP-- 612 +G +YAL+ D+E + L ++ A D G P L S+ +QV VLD+ND+AP L+ P Sbjct: 510 HAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRV 569 Query: 613 APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQ--EPREAFAIGRRTGE 670 G++ VP VVA+V+A D D G N L++ELQ R F +G TGE Sbjct: 570 GGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRVGLYTGE 629 Query: 671 ILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERS 730 I T L + R R L+++ D G PPLT TATV V G+ P A S Sbjct: 630 ISTTRSLDETEAPR-HRLLVLVKDHGEPPLTATATV-LVSLVESGQAPKA--------SS 679 Query: 731 RPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780 R +G +++ + LI I + A S L+L ++ A C+ + E Sbjct: 680 RASAGAVGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSAQPTE 728 >gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo sapiens] Length = 816 Score = 426 bits (1094), Expect = e-119 Identities = 273/770 (35%), Positives = 410/770 (53%), Gaps = 65/770 (8%) Query: 20 LCWVLSV---AQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSLL 74 L W+L A S + YS EE GT +G +A+DL ++++ FR+ + LL Sbjct: 15 LLWLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGDLL 74 Query: 75 RVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPR 134 V +G L V ++ +DRE LC + +C + +V+ ++ HVEV V+D+ND+ PR Sbjct: 75 EVNLQNGILFV-NSRIDREELCRRRAECSIHLEVIV--DRPLQVFHVEVAVKDINDNPPR 131 Query: 135 FPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQC 194 F R + + + E +R PLE D D+GAN RL P+ F ++++T + Sbjct: 132 FSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRL-NPNEYFDLDVKTNEEETNF 190 Query: 195 ADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVE 254 +LVL + LDRE + L ++A DGG+P + T L + VLDAND++P F + ++ V Sbjct: 191 LELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDK-SIYNVR 249 Query: 255 LAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDY 314 L E+AP G+L++ L+A+D DEG N ++V+ F + + F ++ +G + + G +DY Sbjct: 250 LLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDY 309 Query: 315 ERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAA 374 E ++YE+++ A D+ P + CKV+V++ DVNDN P++AIT L P Sbjct: 310 EDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLP------------ 357 Query: 375 AAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGH 434 V E A +++AL+S SDRDSGANGQV C+L H Sbjct: 358 --------------------------VKEDAPLSTVIALISVSDRDSGANGQVTCSLMPH 391 Query: 435 EHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNA 494 F+L + Y +V ++LDRE ++ Y L + A D G+P L +V V D NDNA Sbjct: 392 VPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNA 451 Query: 495 PLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSV 554 P F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E VG +S+YVSV Sbjct: 452 PAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER--PLSSYVSV 509 Query: 555 DPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP-- 612 +G +YAL+ D+E + L ++ A D G P L S+ +QV VLD+ND+AP L+ P Sbjct: 510 HAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRV 569 Query: 613 APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQ--EPREAFAIGRRTGE 670 G++ VP VVA+V+A D D G N L++ELQ R F +G TGE Sbjct: 570 GGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRVGLYTGE 629 Query: 671 ILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERS 730 I T L + R R L+++ D G PPLT TATV V G+ P A S Sbjct: 630 ISTTRSLDETEAPR-HRLLVLVKDHGEPPLTATATV-LVSLVESGQAPKA--------SS 679 Query: 731 RPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780 R +G +++ + LI I + A S L+L ++ A C+ + E Sbjct: 680 RASAGAVGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSAQPTE 728 >gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo sapiens] Length = 803 Score = 424 bits (1091), Expect = e-118 Identities = 287/834 (34%), Positives = 431/834 (51%), Gaps = 76/834 (9%) Query: 2 SPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG-- 59 +P R G CL L W + Q + YS EE GT +G +A+DL ++++ Sbjct: 4 TPEDRLGKQCLLLPLLLLAAWKVGSGQ---LHYSVPEEAKHGTFVGRIAQDLGLELAELV 60 Query: 60 DTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLV 119 FR+ + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ Sbjct: 61 PRLFRMASKDREDLLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVF 117 Query: 120 HVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHS 179 HV+VEVRD+ND+ P FP + V + E + PLE D DVG+N + T +L+ Sbjct: 118 HVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEY 177 Query: 180 PFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAN 239 F ++++ +D + L+L + LDRE A++L L A DGG+P + T L V VLD N Sbjct: 178 -FGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVN 236 Query: 240 DHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRL 299 D++P F Q EV + E+A G+ ++ L+A+D DEG NG + ++F + F + Sbjct: 237 DNAPTFEQSEY-EVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSI 295 Query: 300 DPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPL 359 D +G + + G +D+E+++ Y++ + A D+G P A C V+VRI D NDN P+IA+T L Sbjct: 296 DRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSL 355 Query: 360 AAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDR 419 + P V E A +++AL+S +D Sbjct: 356 SLP--------------------------------------VREDAQFGTVIALISVNDL 377 Query: 420 DSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRT 479 DSGANGQV C+L H F+L + Y +V ++LDRE ++ Y L + A D G+P L Sbjct: 378 DSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWA 437 Query: 480 VRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEA 539 +V V D NDNAP F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E Sbjct: 438 TASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVER 497 Query: 540 EVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRV 599 VG A+S+Y+SV +G +YAL+ D+E L L ++ A D G P L S+ +QV V Sbjct: 498 RVGER--ALSSYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFV 555 Query: 600 LDQNDHAPVLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQ--Q 655 LD+ND+AP L+ P G++ VP VVA+V+A DAD G N L++ELQ Sbjct: 556 LDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPA 615 Query: 656 QEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGG 715 R F +G TGEI T L + R R L+++ D G P LT TATV V G Sbjct: 616 SSARFPFRVGLYTGEISTTRVLDEADSPR-HRLLVLVKDHGEPALTATATV-LVSLVESG 673 Query: 716 RGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775 + P A +S S + P + + V+ ++I + A S L+L ++ A C+ Sbjct: 674 QAPKA-SSRASVGAAGPEAALVDVN--------VYLIIAICAVSSLLVLTLLLYTALRCS 724 Query: 776 RRKKEVRKGGALREERP-----GAAGGGASAPGSPEEAARGAGPRPNMFDVLTF 824 E GA ++P A G + + + G GP P M D++ F Sbjct: 725 APPTE----GACTADKPTLVCSSAVGSWSYSQQRRQRVCSGEGP-PKM-DLMAF 772 >gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens] Length = 950 Score = 424 bits (1091), Expect = e-118 Identities = 287/834 (34%), Positives = 431/834 (51%), Gaps = 76/834 (9%) Query: 2 SPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG-- 59 +P R G CL L W + Q + YS EE GT +G +A+DL ++++ Sbjct: 4 TPEDRLGKQCLLLPLLLLAAWKVGSGQ---LHYSVPEEAKHGTFVGRIAQDLGLELAELV 60 Query: 60 DTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLV 119 FR+ + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ Sbjct: 61 PRLFRMASKDREDLLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVF 117 Query: 120 HVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHS 179 HV+VEVRD+ND+ P FP + V + E + PLE D DVG+N + T +L+ Sbjct: 118 HVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEY 177 Query: 180 PFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAN 239 F ++++ +D + L+L + LDRE A++L L A DGG+P + T L V VLD N Sbjct: 178 -FGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVN 236 Query: 240 DHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRL 299 D++P F Q EV + E+A G+ ++ L+A+D DEG NG + ++F + F + Sbjct: 237 DNAPTFEQSEY-EVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSI 295 Query: 300 DPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPL 359 D +G + + G +D+E+++ Y++ + A D+G P A C V+VRI D NDN P+IA+T L Sbjct: 296 DRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSL 355 Query: 360 AAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDR 419 + P V E A +++AL+S +D Sbjct: 356 SLP--------------------------------------VREDAQFGTVIALISVNDL 377 Query: 420 DSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRT 479 DSGANGQV C+L H F+L + Y +V ++LDRE ++ Y L + A D G+P L Sbjct: 378 DSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWA 437 Query: 480 VRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEA 539 +V V D NDNAP F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E Sbjct: 438 TASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVER 497 Query: 540 EVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRV 599 VG A+S+Y+SV +G +YAL+ D+E L L ++ A D G P L S+ +QV V Sbjct: 498 RVGER--ALSSYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFV 555 Query: 600 LDQNDHAPVLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQ--Q 655 LD+ND+AP L+ P G++ VP VVA+V+A DAD G N L++ELQ Sbjct: 556 LDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPA 615 Query: 656 QEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGG 715 R F +G TGEI T L + R R L+++ D G P LT TATV V G Sbjct: 616 SSARFPFRVGLYTGEISTTRVLDEADSPR-HRLLVLVKDHGEPALTATATV-LVSLVESG 673 Query: 716 RGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775 + P A +S S + P + + V+ ++I + A S L+L ++ A C+ Sbjct: 674 QAPKA-SSRASVGAAGPEAALVDVN--------VYLIIAICAVSSLLVLTLLLYTALRCS 724 Query: 776 RRKKEVRKGGALREERP-----GAAGGGASAPGSPEEAARGAGPRPNMFDVLTF 824 E GA ++P A G + + + G GP P M D++ F Sbjct: 725 APPTE----GACTADKPTLVCSSAVGSWSYSQQRRQRVCSGEGP-PKM-DLMAF 772 >gi|14165400 protocadherin alpha 1 isoform 2 precursor [Homo sapiens] Length = 807 Score = 422 bits (1085), Expect = e-118 Identities = 275/768 (35%), Positives = 409/768 (53%), Gaps = 70/768 (9%) Query: 20 LCWVLSVAQ----SKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSL 73 L W+L +A S + YS EE GT +G +A+DL ++++ FR+ + + L Sbjct: 15 LLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDL 74 Query: 74 LRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAP 133 L V +G L V ++ +DRE LC + +C + ++++ ++ HVEV+V+D+ND+ P Sbjct: 75 LEVNLQNGILFV-NSRIDREELCQWSAECSIHLELIA--DRPLQVFHVEVKVKDINDNPP 131 Query: 134 RFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQ 193 F + + + E + +R P+E D D+GAN L T L+ P F ++++ + ++ Sbjct: 132 VFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLS-PSDYFSLDVEASDELSK 190 Query: 194 CADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEV 253 L L + LDRE L L A DGG+P T L + VLD ND++P F Q AV V Sbjct: 191 SLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQ-AVYRV 249 Query: 254 ELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVD 313 L E G+L+ L+A+D DEG NG+VVF+F + + + F++D SG + L +D Sbjct: 250 HLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLD 309 Query: 314 YERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAA 373 YE +YE+ V+A D+G P + CKV+V++ DVNDNAP++A+T L P Sbjct: 310 YEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLP----------- 358 Query: 374 AAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYG 433 + E A +++AL++ SDRDSGANGQV C+L Sbjct: 359 ---------------------------IREDAPLSTVIALITVSDRDSGANGQVTCSLMP 391 Query: 434 HEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDN 493 H F+L + Y +V ++LDRE ++ Y L + A D G+P L +V V D NDN Sbjct: 392 HVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDN 451 Query: 494 APLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVS 553 AP F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E VG A+S YVS Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER--ALSNYVS 509 Query: 554 VDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPA 613 V +G +YAL+ D+E L L ++ A D G P L S+ +QV VLD+ND+AP L+ P Sbjct: 510 VHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPR 569 Query: 614 PAN--GSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREAFAIGRRTG 669 G++ VP VVA+V+A DAD G N L++ELQ R F +G TG Sbjct: 570 VGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFRVGLYTG 629 Query: 670 EILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPER 729 EI T L + R +R L+++ D G P LT TATV V G+ P A + A Sbjct: 630 EISTTRVLDEADLSR-YRLLVLVKDHGEPALTATATV-LVSLVESGQAPKASSRAS---- 683 Query: 730 SRPPGSRLGVSG--SVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775 +GV+G + L ++I + A S L+L ++ A C+ Sbjct: 684 -------VGVAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCS 724 >gi|9256582 protocadherin alpha 1 isoform 1 precursor [Homo sapiens] Length = 950 Score = 422 bits (1085), Expect = e-118 Identities = 275/768 (35%), Positives = 409/768 (53%), Gaps = 70/768 (9%) Query: 20 LCWVLSVAQ----SKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSL 73 L W+L +A S + YS EE GT +G +A+DL ++++ FR+ + + L Sbjct: 15 LLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDL 74 Query: 74 LRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAP 133 L V +G L V ++ +DRE LC + +C + ++++ ++ HVEV+V+D+ND+ P Sbjct: 75 LEVNLQNGILFV-NSRIDREELCQWSAECSIHLELIA--DRPLQVFHVEVKVKDINDNPP 131 Query: 134 RFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQ 193 F + + + E + +R P+E D D+GAN L T L+ P F ++++ + ++ Sbjct: 132 VFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLS-PSDYFSLDVEASDELSK 190 Query: 194 CADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEV 253 L L + LDRE L L A DGG+P T L + VLD ND++P F Q AV V Sbjct: 191 SLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQ-AVYRV 249 Query: 254 ELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVD 313 L E G+L+ L+A+D DEG NG+VVF+F + + + F++D SG + L +D Sbjct: 250 HLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLD 309 Query: 314 YERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAA 373 YE +YE+ V+A D+G P + CKV+V++ DVNDNAP++A+T L P Sbjct: 310 YEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLP----------- 358 Query: 374 AAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYG 433 + E A +++AL++ SDRDSGANGQV C+L Sbjct: 359 ---------------------------IREDAPLSTVIALITVSDRDSGANGQVTCSLMP 391 Query: 434 HEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDN 493 H F+L + Y +V ++LDRE ++ Y L + A D G+P L +V V D NDN Sbjct: 392 HVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDN 451 Query: 494 APLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVS 553 AP F +P Y V V+ENNPPG ++ TV+ARD D N V+Y L+E VG A+S YVS Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER--ALSNYVS 509 Query: 554 VDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPA 613 V +G +YAL+ D+E L L ++ A D G P L S+ +QV VLD+ND+AP L+ P Sbjct: 510 VHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPR 569 Query: 614 PAN--GSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREAFAIGRRTG 669 G++ VP VVA+V+A DAD G N L++ELQ R F +G TG Sbjct: 570 VGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFRVGLYTG 629 Query: 670 EILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPER 729 EI T L + R +R L+++ D G P LT TATV V G+ P A + A Sbjct: 630 EISTTRVLDEADLSR-YRLLVLVKDHGEPALTATATV-LVSLVESGQAPKASSRAS---- 683 Query: 730 SRPPGSRLGVSG--SVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775 +GV+G + L ++I + A S L+L ++ A C+ Sbjct: 684 -------VGVAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCS 724 >gi|9256594 protocadherin alpha 7 isoform 1 precursor [Homo sapiens] Length = 937 Score = 422 bits (1085), Expect = e-118 Identities = 284/839 (33%), Positives = 430/839 (51%), Gaps = 79/839 (9%) Query: 15 LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSS 72 L LF + A + YS EE G +G +A+DL ++++ FR + +F Sbjct: 14 LLLFIIILAAWEAGRGQLHYSVPEEAKHGNFVGRIAQDLGLELAELVPRLFRAVCKFRGD 73 Query: 73 LLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHA 132 LL V +G L V ++ +DRE LCG++ +C + +V+ + ++ HV+VEV+D+ND+ Sbjct: 74 LLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--ERPLQVFHVDVEVKDINDNP 130 Query: 133 PRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGA 192 P FP Q + ++E + +R PLE D D+G N L T RL+ P+ F +++ T Sbjct: 131 PVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLS-PNEYFFLDVPTSNQQV 189 Query: 193 QCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAE 252 + LVL + LDRE L L A DGG+P + T L + VLD ND++P F + + Sbjct: 190 KPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDR-TLYT 248 Query: 253 VELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPV 312 V+L E+ +G+L++ +A+D DEG NGD++++F + P+ + F +DP SG +T+ G + Sbjct: 249 VKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHM 308 Query: 313 DYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAA 372 D+E +++ V A D+G P A C V+V + DVNDNAP + +T L+ P Sbjct: 309 DFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLP---------- 358 Query: 373 AAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALY 432 +PE A +++ L+S DRD G NGQV C+L Sbjct: 359 ----------------------------IPEDAQPGTVITLISVFDRDFGVNGQVTCSLT 390 Query: 433 GHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDEND 492 F+L + Y +V ++LDRE ++ Y L + A D G+P L +V V D ND Sbjct: 391 PRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450 Query: 493 NAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYV 552 NAP F +P Y V V+ENNPPG ++ TV+A D D +N V+Y L+E VG A+S+YV Sbjct: 451 NAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGER--ALSSYV 508 Query: 553 SVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP 612 SV +G +YAL+ D+E L L ++ A D G P L S+ +QV VLD+ND+AP L+ P Sbjct: 509 SVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAP 568 Query: 613 --APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREA--FAIGRRT 668 G++ VP VVA+V+A DAD G N L++ELQ + F +G T Sbjct: 569 RVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFRVGLYT 628 Query: 669 GEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPE 728 GEI T L + R R L+++ D G P LT TATV V G+ P A + A Sbjct: 629 GEISTTRALDETDAPR-HRLLVLVKDHGEPSLTATATV-LVSLVESGQAPKASSRAS--- 683 Query: 729 RSRPPGSRLGVSG--SVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGA 786 LG++G + L ++I + A S L+L ++ A C+ E GA Sbjct: 684 --------LGIAGPETELVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPSSE----GA 731 Query: 787 LREERP-----GAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAP 840 +P A G + + + G GP D++ F + P G + D P Sbjct: 732 CSLVKPTLVCSSAVGSWSFSQQRRQRVCSGEGPPKT--DLMAF--SPSLPQGPSSTDNP 786 >gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precursor [Homo sapiens] Length = 932 Score = 421 bits (1083), Expect = e-117 Identities = 272/778 (34%), Positives = 415/778 (53%), Gaps = 79/778 (10%) Query: 32 VRYSTFEEDAPGTVIGTLAEDLHMKVS--GDTSFRLMKQFNSSLLRVREGDGQLTVGDAG 89 +RYS EE G+ +G ++ DL ++ + R++ + + L + G L Sbjct: 31 IRYSVPEELEKGSRVGDISRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGR- 89 Query: 90 LDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAA 149 +DRE LC A +C L D++ +++ ++ VEVEVRD+ND+AP F +++ +++SE AA Sbjct: 90 IDREELCMGAIKCQLNLDILM--EDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAA 147 Query: 150 VGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQA 209 R PL D D+G N LQ+ L+ P++ F + +Q ADG++ +LVL + LDRE +A Sbjct: 148 TEMRFPLPHAWDPDIGKNSLQSYELS-PNTHFSLIVQNGADGSKYPELVLKRALDREEKA 206 Query: 210 AYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLD 269 A+ L L A DGG P R+ TA + V VLDAND++PAF Q + E+ +G+ LL ++ Sbjct: 207 AHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEY-RASVPENLALGTQLLVVN 265 Query: 270 AADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDR 329 A DPDEG N +V ++F +A ++F+LD SG ++ G +D+E Y+++V+A D Sbjct: 266 ATDPDEGVNAEVRYSF-RYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDN 324 Query: 330 GPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAG 389 +A KV++ + DVNDNAP++ +T LA Sbjct: 325 AG--YSARAKVLITVLDVNDNAPEVVLTSLA----------------------------- 353 Query: 390 AGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLV 449 S VPE + R +L+AL++ +D+DS NGQV C + G+ F+L+ +Y Y + Sbjct: 354 ---------SSVPENSPRGTLIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSL 404 Query: 450 VTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVREN 509 VT LDRE++ YN+T+ A DRG PPL T ++ V D NDN P+F + Y + EN Sbjct: 405 VTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPEN 464 Query: 510 NPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDY 569 NP G L +V A D D N Q+TY L E + G ++S+YVS++ TG +YAL SFDY Sbjct: 465 NPRGVSLVSVTAHDPDCEENAQITYSLAENTI--QGASLSSYVSINSDTGVLYALSSFDY 522 Query: 570 ETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPA-PANGSLEVAVPGRTA 628 E R L V++ A D G P LSS+ + + VLDQND+AP +++PA P +GS V + R+A Sbjct: 523 EQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSA 582 Query: 629 K-DTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEI-----LLTGDLSQEPP 682 + +V +V A D D G N L++ L + F++G TGE+ LL D ++ Sbjct: 583 EPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQ-- 640 Query: 683 GRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGS 742 ++ + D G+PPL+ T T++ V + A S SP S L Sbjct: 641 ----SLVVAVQDHGQPPLSATVTLTVAVADSIPQVLADLGSLESPANSETSDLTL----- 691 Query: 743 VLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGAS 800 +V+ V A SC L I+ +A R + K L+ G G AS Sbjct: 692 -------YLVVAVAAVSCVFLAFVILLLAL----RLRRWHKSRLLQASGGGLTGAPAS 738 Score = 90.5 bits (223), Expect = 8e-18 Identities = 95/317 (29%), Positives = 135/317 (42%), Gaps = 55/317 (17%) Query: 394 EAGATSL---VPEGAARESLVALVSTSDRDSG------ANGQVRCALYGHEH-FRLQPAY 443 E G T + VPE + S V +S RD G A VR G F L P Sbjct: 25 ETGCTQIRYSVPEELEKGSRVGDIS---RDLGLEPRELAERGVRIIPRGRTQLFALNPR- 80 Query: 444 AGSYLVVTAASLDRERIA------EYNLTLVAEDRGAPPLRTVRPY--TVRVGDENDNAP 495 +GS +VTA +DRE + + NL ++ ED+ V+ Y V V D NDNAP Sbjct: 81 SGS--LVTAGRIDREELCMGAIKCQLNLDILMEDK-------VKIYGVEVEVRDINDNAP 131 Query: 496 LFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVD 555 F E+ + EN A D D+G+N +Y L + +T+ S+ Sbjct: 132 YFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYEL----------SPNTHFSLI 181 Query: 556 PATGA-------IYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPV 608 GA + R+ D E + + ASDGG P + +A ++V VLD ND+AP Sbjct: 182 VQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPA 241 Query: 609 LVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREA--FAIGR 666 P +VP A T + V A D DEG N E+ + + + + A F + Sbjct: 242 FAQP-----EYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDC 296 Query: 667 RTGEILLTGDLSQEPPG 683 +G I G+L E G Sbjct: 297 NSGTISTIGELDHEESG 313 >gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precursor [Homo sapiens] Length = 820 Score = 421 bits (1083), Expect = e-117 Identities = 272/778 (34%), Positives = 415/778 (53%), Gaps = 79/778 (10%) Query: 32 VRYSTFEEDAPGTVIGTLAEDLHMKVS--GDTSFRLMKQFNSSLLRVREGDGQLTVGDAG 89 +RYS EE G+ +G ++ DL ++ + R++ + + L + G L Sbjct: 31 IRYSVPEELEKGSRVGDISRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGR- 89 Query: 90 LDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAA 149 +DRE LC A +C L D++ +++ ++ VEVEVRD+ND+AP F +++ +++SE AA Sbjct: 90 IDREELCMGAIKCQLNLDILM--EDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAA 147 Query: 150 VGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQA 209 R PL D D+G N LQ+ L+ P++ F + +Q ADG++ +LVL + LDRE +A Sbjct: 148 TEMRFPLPHAWDPDIGKNSLQSYELS-PNTHFSLIVQNGADGSKYPELVLKRALDREEKA 206 Query: 210 AYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLD 269 A+ L L A DGG P R+ TA + V VLDAND++PAF Q + E+ +G+ LL ++ Sbjct: 207 AHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEY-RASVPENLALGTQLLVVN 265 Query: 270 AADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDR 329 A DPDEG N +V ++F +A ++F+LD SG ++ G +D+E Y+++V+A D Sbjct: 266 ATDPDEGVNAEVRYSF-RYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDN 324 Query: 330 GPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAG 389 +A KV++ + DVNDNAP++ +T LA Sbjct: 325 AG--YSARAKVLITVLDVNDNAPEVVLTSLA----------------------------- 353 Query: 390 AGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLV 449 S VPE + R +L+AL++ +D+DS NGQV C + G+ F+L+ +Y Y + Sbjct: 354 ---------SSVPENSPRGTLIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSL 404 Query: 450 VTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVREN 509 VT LDRE++ YN+T+ A DRG PPL T ++ V D NDN P+F + Y + EN Sbjct: 405 VTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPEN 464 Query: 510 NPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDY 569 NP G L +V A D D N Q+TY L E + G ++S+YVS++ TG +YAL SFDY Sbjct: 465 NPRGVSLVSVTAHDPDCEENAQITYSLAENTI--QGASLSSYVSINSDTGVLYALSSFDY 522 Query: 570 ETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPA-PANGSLEVAVPGRTA 628 E R L V++ A D G P LSS+ + + VLDQND+AP +++PA P +GS V + R+A Sbjct: 523 EQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSA 582 Query: 629 K-DTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEI-----LLTGDLSQEPP 682 + +V +V A D D G N L++ L + F++G TGE+ LL D ++ Sbjct: 583 EPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQ-- 640 Query: 683 GRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGS 742 ++ + D G+PPL+ T T++ V + A S SP S L Sbjct: 641 ----SLVVAVQDHGQPPLSATVTLTVAVADSIPQVLADLGSLESPANSETSDLTL----- 691 Query: 743 VLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGAS 800 +V+ V A SC L I+ +A R + K L+ G G AS Sbjct: 692 -------YLVVAVAAVSCVFLAFVILLLAL----RLRRWHKSRLLQASGGGLTGAPAS 738 Score = 90.5 bits (223), Expect = 8e-18 Identities = 95/317 (29%), Positives = 135/317 (42%), Gaps = 55/317 (17%) Query: 394 EAGATSL---VPEGAARESLVALVSTSDRDSG------ANGQVRCALYGHEH-FRLQPAY 443 E G T + VPE + S V +S RD G A VR G F L P Sbjct: 25 ETGCTQIRYSVPEELEKGSRVGDIS---RDLGLEPRELAERGVRIIPRGRTQLFALNPR- 80 Query: 444 AGSYLVVTAASLDRERIA------EYNLTLVAEDRGAPPLRTVRPY--TVRVGDENDNAP 495 +GS +VTA +DRE + + NL ++ ED+ V+ Y V V D NDNAP Sbjct: 81 SGS--LVTAGRIDREELCMGAIKCQLNLDILMEDK-------VKIYGVEVEVRDINDNAP 131 Query: 496 LFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVD 555 F E+ + EN A D D+G+N +Y L + +T+ S+ Sbjct: 132 YFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYEL----------SPNTHFSLI 181 Query: 556 PATGA-------IYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPV 608 GA + R+ D E + + ASDGG P + +A ++V VLD ND+AP Sbjct: 182 VQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPA 241 Query: 609 LVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREA--FAIGR 666 P +VP A T + V A D DEG N E+ + + + + A F + Sbjct: 242 FAQP-----EYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDC 296 Query: 667 RTGEILLTGDLSQEPPG 683 +G I G+L E G Sbjct: 297 NSGTISTIGELDHEESG 313 >gi|14165381 protocadherin alpha 10 isoform 2 precursor [Homo sapiens] Length = 844 Score = 421 bits (1083), Expect = e-117 Identities = 275/780 (35%), Positives = 416/780 (53%), Gaps = 68/780 (8%) Query: 8 GSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRL 65 G CL L W + Q + YS +EE GT +G +A+DL ++++ FR+ Sbjct: 9 GVQCLLLSLLLLAAWEVGSGQ---LHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRV 65 Query: 66 MKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEV 125 + + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ HV+VEV Sbjct: 66 ASKRHGDLLEVNLQNGILFV-NSRIDREELCGRSVECSIHLEVIV--DRPLQVFHVDVEV 122 Query: 126 RDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVEL 185 +D+ND+ PRF + + + E + +R PLE D DVG N L T +L+ P+ F +++ Sbjct: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLS-PNEYFVLDI 181 Query: 186 QTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAF 245 + D + LVL + LDRE L L A DGG+P + + +L + VLDAND++P F Sbjct: 182 INKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIF 241 Query: 246 PQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGR 305 + V EV++ E+ +L++ L+A+D DEG N +++++F + PP RR F ++ R+G Sbjct: 242 DR-PVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE 300 Query: 306 LTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAP 365 + + +D+E +TYE+ V D+G P C V+V + D NDN+P++ +T L+ P Sbjct: 301 IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLP--- 357 Query: 366 ATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANG 425 V E A +++AL+S SD DSGANG Sbjct: 358 -----------------------------------VKEDAQVGTVIALISVSDHDSGANG 382 Query: 426 QVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTV 485 QV C+L H F+L Y Y +V ++LDRER++ Y L + A D G+PPL +V Sbjct: 383 QVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSV 442 Query: 486 RVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAG 545 V D NDNAP F + Y V V+ENNPPG ++ TV+A D D N V+Y L+E +G Sbjct: 443 EVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGER- 501 Query: 546 GAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDH 605 ++S+YVSV +G +YAL+ D+E L L ++ A DGG P L S+ +QV VLD+ND+ Sbjct: 502 -SLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDN 560 Query: 606 AP-VLVHPA-PANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREA 661 AP +L PA A G++ V VVA+V+A DAD G N L++ELQ R Sbjct: 561 APALLASPAGSAGGAVSELVLRSVVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIP 620 Query: 662 FAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAP 721 F +G TGEI T L + R R L+++ D G P LT TATV V G + P A Sbjct: 621 FRVGLYTGEISTTRALDETDSPRQ-RLLVLVKDHGEPSLTATATV-LVSLVEGSQAPKAS 678 Query: 722 ASAGSPERSRPPGSRLGVSGSVLQWDTPL-IVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780 + A +GV+ V D + ++I + A S L+L ++ A C+ E Sbjct: 679 SRAS-----------VGVAPEVALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAAPTE 727 >gi|9256574 protocadherin alpha 10 isoform 1 precursor [Homo sapiens] Length = 948 Score = 421 bits (1083), Expect = e-117 Identities = 275/780 (35%), Positives = 416/780 (53%), Gaps = 68/780 (8%) Query: 8 GSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRL 65 G CL L W + Q + YS +EE GT +G +A+DL ++++ FR+ Sbjct: 9 GVQCLLLSLLLLAAWEVGSGQ---LHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRV 65 Query: 66 MKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEV 125 + + LL V +G L V ++ +DRE LCG++ +C + +V+ ++ HV+VEV Sbjct: 66 ASKRHGDLLEVNLQNGILFV-NSRIDREELCGRSVECSIHLEVIV--DRPLQVFHVDVEV 122 Query: 126 RDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVEL 185 +D+ND+ PRF + + + E + +R PLE D DVG N L T +L+ P+ F +++ Sbjct: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLS-PNEYFVLDI 181 Query: 186 QTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAF 245 + D + LVL + LDRE L L A DGG+P + + +L + VLDAND++P F Sbjct: 182 INKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIF 241 Query: 246 PQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGR 305 + V EV++ E+ +L++ L+A+D DEG N +++++F + PP RR F ++ R+G Sbjct: 242 DR-PVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE 300 Query: 306 LTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAP 365 + + +D+E +TYE+ V D+G P C V+V + D NDN+P++ +T L+ P Sbjct: 301 IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLP--- 357 Query: 366 ATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANG 425 V E A +++AL+S SD DSGANG Sbjct: 358 -----------------------------------VKEDAQVGTVIALISVSDHDSGANG 382 Query: 426 QVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTV 485 QV C+L H F+L Y Y +V ++LDRER++ Y L + A D G+PPL +V Sbjct: 383 QVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSV 442 Query: 486 RVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAG 545 V D NDNAP F + Y V V+ENNPPG ++ TV+A D D N V+Y L+E +G Sbjct: 443 EVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGER- 501 Query: 546 GAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDH 605 ++S+YVSV +G +YAL+ D+E L L ++ A DGG P L S+ +QV VLD+ND+ Sbjct: 502 -SLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDN 560 Query: 606 AP-VLVHPA-PANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREA 661 AP +L PA A G++ V VVA+V+A DAD G N L++ELQ R Sbjct: 561 APALLASPAGSAGGAVSELVLRSVVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIP 620 Query: 662 FAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAP 721 F +G TGEI T L + R R L+++ D G P LT TATV V G + P A Sbjct: 621 FRVGLYTGEISTTRALDETDSPRQ-RLLVLVKDHGEPSLTATATV-LVSLVEGSQAPKAS 678 Query: 722 ASAGSPERSRPPGSRLGVSGSVLQWDTPL-IVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780 + A +GV+ V D + ++I + A S L+L ++ A C+ E Sbjct: 679 SRAS-----------VGVAPEVALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAAPTE 727 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.133 0.394 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 48,193,355 Number of Sequences: 37866 Number of extensions: 2647030 Number of successful extensions: 24277 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 227 Number of HSP's successfully gapped in prelim test: 383 Number of HSP's that attempted gapping in prelim test: 14337 Number of HSP's gapped (non-prelim): 4189 length of query: 1070 length of database: 18,247,518 effective HSP length: 113 effective length of query: 957 effective length of database: 13,968,660 effective search space: 13368007620 effective search space used: 13368007620 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.