Guide to the Human Genome
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Search of human proteins with 6631102

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|6631102 protocadherin 8 isoform 1 precursor [Homo sapiens]
         (1070 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6631102 protocadherin 8 isoform 1 precursor [Homo sapiens]        2133   0.0  
gi|14589937 protocadherin 8 isoform 2 precursor [Homo sapiens]       1803   0.0  
gi|14589929 protocadherin 18 precursor [Homo sapiens]                 588   e-168
gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]       520   e-147
gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]       506   e-143
gi|94538350 protocadherin 17 precursor [Homo sapiens]                 506   e-143
gi|157426847 protocadherin 19 isoform a [Homo sapiens]                471   e-132
gi|157426845 protocadherin 19 isoform b [Homo sapiens]                471   e-132
gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precurso...   448   e-125
gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precurs...   448   e-125
gi|7706113 protocadherin 12 precursor [Homo sapiens]                  446   e-125
gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precurs...   439   e-123
gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precurs...   439   e-123
gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo sap...   439   e-123
gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo sapi...   439   e-123
gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo sapi...   438   e-122
gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens]   438   e-122
gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo sapi...   426   e-119
gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens]   426   e-119
gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens]   426   e-119
gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo sapi...   426   e-119
gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo sapi...   424   e-118
gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens]   424   e-118
gi|14165400 protocadherin alpha 1 isoform 2 precursor [Homo sapi...   422   e-118
gi|9256582 protocadherin alpha 1 isoform 1 precursor [Homo sapiens]   422   e-118
gi|9256594 protocadherin alpha 7 isoform 1 precursor [Homo sapiens]   422   e-118
gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precurs...   421   e-117
gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precur...   421   e-117
gi|14165381 protocadherin alpha 10 isoform 2 precursor [Homo sap...   421   e-117
gi|9256574 protocadherin alpha 10 isoform 1 precursor [Homo sapi...   421   e-117

>gi|6631102 protocadherin 8 isoform 1 precursor [Homo sapiens]
          Length = 1070

 Score = 2133 bits (5528), Expect = 0.0
 Identities = 1070/1070 (100%), Positives = 1070/1070 (100%)

Query: 1    MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD 60
            MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD
Sbjct: 1    MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD 60

Query: 61   TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH 120
            TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH
Sbjct: 61   TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH 120

Query: 121  VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180
            VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP
Sbjct: 121  VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180

Query: 181  FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240
            FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND
Sbjct: 181  FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240

Query: 241  HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD 300
            HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD
Sbjct: 241  HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD 300

Query: 301  PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA 360
            PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA
Sbjct: 301  PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA 360

Query: 361  APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD 420
            APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD
Sbjct: 361  APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD 420

Query: 421  SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480
            SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV
Sbjct: 421  SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480

Query: 481  RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540
            RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE
Sbjct: 481  RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540

Query: 541  VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600
            VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL
Sbjct: 541  VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600

Query: 601  DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660
            DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE
Sbjct: 601  DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660

Query: 661  AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720
            AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA
Sbjct: 661  AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720

Query: 721  PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
            PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE
Sbjct: 721  PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780

Query: 781  VRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAP 840
            VRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAP
Sbjct: 781  VRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAP 840

Query: 841  PPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHS 900
            PPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHS
Sbjct: 841  PPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHS 900

Query: 901  FNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGH 960
            FNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGH
Sbjct: 901  FNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGH 960

Query: 961  SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK 1020
            SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK
Sbjct: 961  SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK 1020

Query: 1021 VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV 1070
            VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV
Sbjct: 1021 VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV 1070


>gi|14589937 protocadherin 8 isoform 2 precursor [Homo sapiens]
          Length = 973

 Score = 1803 bits (4671), Expect = 0.0
 Identities = 944/1070 (88%), Positives = 949/1070 (88%), Gaps = 97/1070 (9%)

Query: 1    MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD 60
            MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD
Sbjct: 1    MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD 60

Query: 61   TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH 120
            TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH
Sbjct: 61   TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH 120

Query: 121  VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180
            VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP
Sbjct: 121  VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180

Query: 181  FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240
            FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND
Sbjct: 181  FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240

Query: 241  HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD 300
            HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD
Sbjct: 241  HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD 300

Query: 301  PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA 360
            PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA
Sbjct: 301  PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA 360

Query: 361  APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD 420
            APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD
Sbjct: 361  APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD 420

Query: 421  SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480
            SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV
Sbjct: 421  SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480

Query: 481  RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540
            RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE
Sbjct: 481  RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540

Query: 541  VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600
            VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL
Sbjct: 541  VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600

Query: 601  DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660
            DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE
Sbjct: 601  DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660

Query: 661  AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720
            AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA
Sbjct: 661  AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720

Query: 721  PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
            PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE
Sbjct: 721  PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780

Query: 781  VRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAP 840
                             GAS                        PG GK P       AP
Sbjct: 781  PY---------------GAS------------------------PGFGKEP-------AP 794

Query: 841  PPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHS 900
            P AV      G    + +G  A  F G+                                
Sbjct: 795  PVAV----WKGHSFNTISGREAEKFSGKD------------------------------- 819

Query: 901  FNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGH 960
                SG+    F+  DS            DISGDALKKDLINHMQSGLWACTAECKILGH
Sbjct: 820  ----SGKGDSDFNDSDS------------DISGDALKKDLINHMQSGLWACTAECKILGH 863

Query: 961  SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK 1020
            SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK
Sbjct: 864  SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK 923

Query: 1021 VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV 1070
            VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV
Sbjct: 924  VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV 973


>gi|14589929 protocadherin 18 precursor [Homo sapiens]
          Length = 1135

 Score =  588 bits (1516), Expect = e-168
 Identities = 363/1000 (36%), Positives = 535/1000 (53%), Gaps = 101/1000 (10%)

Query: 30  KTVRYSTFEEDAPGTVIGTLAED-----LHMKVSGDTSFRLMKQFNSSLLRVREGDGQLT 84
           K ++Y  +EE   G+VI  L+ED     L +       FR M++ NS LL V E +G+++
Sbjct: 28  KNLKYRIYEEQRVGSVIARLSEDVADVLLKLPNPSTVRFRAMQRGNSPLLVVNEDNGEIS 87

Query: 85  VGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEV 144
           +G A +DRE+LC +   C + FDV++   E  +L H+EVEV D+ND++P+F R+ IP+E+
Sbjct: 88  IG-ATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEI 146

Query: 145 SEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELD 204
           SE AAVGTRIPL+   D DVG N L T  L+  +  F +E++TR DGA+ A+L++++ELD
Sbjct: 147 SESAAVGTRIPLDSAFDPDVGENSLHTYSLSA-NDFFNIEVRTRTDGAKYAELIVVRELD 205

Query: 205 RESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSL 264
           RE +++Y L+L A D G P RS ++ L + + D+ND+SPAF Q +   ++L E++PVG+L
Sbjct: 206 RELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYI-IQLLENSPVGTL 264

Query: 265 LLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDV 324
           LLDL+A DPDEG NG +V++F +   P+    F++D   G LTL   VDYE   +YE+DV
Sbjct: 265 LLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDV 324

Query: 325 RAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADA 384
           +AQD GP    A CK+I+++ DVNDN P+I I  L +PG                     
Sbjct: 325 QAQDLGPNSIPAHCKIIIKVVDVNDNKPEININ-LMSPGKE------------------- 364

Query: 385 SSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYA 444
                         S + EG   ++ VALV   D+DSG NG++ C L+GH HF+LQ  Y 
Sbjct: 365 ------------EISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYE 412

Query: 445 GSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEV 504
            +YL++T A+LDRE+ +EY+LT++AEDRG P L TV+ +TV++ D NDN P F R  YE 
Sbjct: 413 NNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEF 472

Query: 505 SVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYAL 564
            + ENN PGAY+ TV A D DLG NGQVTY +LE+ +   G +++TYV++DP+ GAIYAL
Sbjct: 473 VISENNSPGAYITTVTATDPDLGENGQVTYTILESFI--LGSSITTYVTIDPSNGAIYAL 530

Query: 565 RSFDYETLRQLDVRIQASDGGSP-QLSSSALVQVRVLDQNDHAPVLVHPAPANGSLEVAV 623
           R FD+E + Q+   ++A DGGSP QL S+  V + ++D+ND+ PV++ PA  N + E+ +
Sbjct: 531 RIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITI 590

Query: 624 PGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPG 683
           P        V R++A D D G N EL+  +        F I  R+ +I  T       P 
Sbjct: 591 PKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDI-HTNVSMDSVPY 649

Query: 684 RVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSV 743
             +   ++I D G P L T   +  ++                 E +    S    S S 
Sbjct: 650 TEWELSVIIQDKGNPQLHTKVLLKCMIF----------------EYAESVTSTAMTSVSQ 693

Query: 744 LQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPG 803
              D  +I+II L   C +LL  ++  AT CNR KK+ R       E        ++   
Sbjct: 694 ASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAE--------STYQH 745

Query: 804 SPEEAARGAGPRPNMFDVLTFPGT-------GKAPFGSPAADAPPPAVAAAEVPGSEGGS 856
            P+  +R    + ++  V T  GT         +P  SP  +        +        S
Sbjct: 746 HPKRPSRQI-HKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNS 804

Query: 857 ATGESACHFEGQQRLRGAHAEPYGASPG-----FGKEPAPPVAVWKGHSFN---TISGRE 908
               S+ H      L   HA P             +    P   ++G+ ++     + ++
Sbjct: 805 LVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQD 864

Query: 909 AEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLW-----------ACTAECKI 957
            +KFS KDSG+GDS+  DSD D+  D+    L+    S L+            CT EC++
Sbjct: 865 MDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRV 924

Query: 958 LGHSDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDP 997
           LGHSD+CW P        PSP    + + F      P  P
Sbjct: 925 LGHSDQCWMPPL------PSPSSDYRSNMFIPGEEFPTQP 958


>gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]
          Length = 1040

 Score =  520 bits (1340), Expect = e-147
 Identities = 364/1028 (35%), Positives = 516/1028 (50%), Gaps = 148/1028 (14%)

Query: 15  LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVS--GDTSFRLMKQFNSS 72
           L LF+L W++    S+ + Y+  EE   GT +G +AEDL + ++      F+ +    + 
Sbjct: 4   LLLFALLWMVEGVFSQ-LHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRTP 62

Query: 73  LLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHA 132
            L +    G L V +  +DRE++C Q+P CVL  +V  F +    L  VE+EV D+ND+ 
Sbjct: 63  YLDLNLETGVLYVNEK-IDREQICKQSPSCVLHLEV--FLENPLELFQVEIEVLDINDNP 119

Query: 133 PRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGA 192
           P FP   + VE+SE A  GTR PLE   D DVG N L+   +  P+S F +++QT+ DG 
Sbjct: 120 PSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT-PNSYFSLDVQTQGDGN 178

Query: 193 QCADLVLLQELDRESQAAYSLELVAQDGGR----------------PP---RSATAALSV 233
           + A+LVL + LDRE QA +   L A DGG                 PP   R+ TA L++
Sbjct: 179 RFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTI 238

Query: 234 RVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEA 293
           RVLD+ND+ PAF Q  V  V L E++P G+L++ L+A DPDEG NG+VV++F +   P A
Sbjct: 239 RVLDSNDNVPAFDQ-PVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRA 297

Query: 294 RRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPD 353
           R LF L PR+GRL ++G +DYE    Y++ V+A+D GP    A CKV+VR+ D NDNAP+
Sbjct: 298 RELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPE 357

Query: 354 IAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVAL 413
           I+ + +                                         V EGAA  ++VAL
Sbjct: 358 ISFSTVK--------------------------------------EAVSEGAAPGTVVAL 379

Query: 414 VSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRG 473
            S +DRDS  NGQV+C L G   FRL+ ++   Y +VT A LDRE    Y LT+VA DRG
Sbjct: 380 FSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRG 439

Query: 474 APPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVT 533
            P L T +   V+V D NDNAP F++PVY+V V ENN PGAY+  V+A DRD G N Q+ 
Sbjct: 440 EPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLA 499

Query: 534 YRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQ-LSSS 592
           Y +LE ++   G +V TYVS++   G +YALRSFDYE L+    +++A D GSPQ L+ +
Sbjct: 500 YSILECQI--QGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGN 557

Query: 593 ALVQVRVLDQNDHAPVLVHPAPA-NGSLEVAVPGRTAKDT-VVARVQARDADEGANGELA 650
           A V + ++DQND+AP +V P P  NG+    V  R+A+   ++ RV A DAD+G N  L 
Sbjct: 558 ATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLT 617

Query: 651 FELQQQEPREAFAIGRRTGEILLTGDL-SQEPPGRVFRALLVISDGGRPPLTTTAT--VS 707
           + + +      F +  RTGE+     + ++  P R +  ++ + D G+PPL++TAT  V 
Sbjct: 618 YSIVRGNEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQ 677

Query: 708 FVVTAGGGRGPAAPASAGSPERSRPPGSRLGVS------------GSV------------ 743
            V  A   +G       GS E  RP  S  G +            GSV            
Sbjct: 678 LVDGAVEPQGGGGSGGGGSGEHQRPSRSGGGETSLDLTLILIIALGSVSFIFLLAMIVLA 737

Query: 744 --LQWDTPLIVIIVLAGSCTLLLAAIIAIATTC-----NRRKKEVRKGGALREERPGAAG 796
              Q +  L +   LA  C L         +TC       RKK++ K   +  +      
Sbjct: 738 VRCQKEKKLNIYTCLASDCCLCCCCCGGGGSTCCGRQARARKKKLSKSDIMLVQSSNVPS 797

Query: 797 GGASAPGSPEEAARGAGPRPN----MFDVLTFPGTGKAP--FGSPAADA--------PPP 842
             A  P    E + G G   +     + V   P + K    F  P + +        P  
Sbjct: 798 NPAQVP---IEESGGFGSHHHNQNYCYQVCLTPESAKTDLMFLKPCSPSRSTDTEHNPCG 854

Query: 843 AVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHSFN 902
           A+            + G    +    QR   ++                   V +    N
Sbjct: 855 AIVTGYTDQQPDIISNGSILSNETKHQRAELSYL------------------VDRPRRVN 896

Query: 903 TISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKK--DLINHMQSGLWACTAECKILGH 960
           + + +EA+  S KDSG GDS+  DSD D +  A     DL ++       CT ECK LGH
Sbjct: 897 SSAFQEADIVSSKDSGHGDSEQGDSDHDATNRAQSAGMDLFSN-------CTEECKALGH 949

Query: 961 SDRCWSPS 968
           SDRCW PS
Sbjct: 950 SDRCWMPS 957


>gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]
          Length = 896

 Score =  506 bits (1304), Expect = e-143
 Identities = 315/792 (39%), Positives = 444/792 (56%), Gaps = 77/792 (9%)

Query: 15  LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVS--GDTSFRLMKQFNSS 72
           L LF+L W++    S+ + Y+  EE   GT +G +AEDL + ++      F+ +    + 
Sbjct: 4   LLLFALLWMVEGVFSQ-LHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRTP 62

Query: 73  LLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHA 132
            L +    G L V +  +DRE++C Q+P CVL  +V  F +    L  VE+EV D+ND+ 
Sbjct: 63  YLDLNLETGVLYVNEK-IDREQICKQSPSCVLHLEV--FLENPLELFQVEIEVLDINDNP 119

Query: 133 PRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGA 192
           P FP   + VE+SE A  GTR PLE   D DVG N L+   +  P+S F +++QT+ DG 
Sbjct: 120 PSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEIT-PNSYFSLDVQTQGDGN 178

Query: 193 QCADLVLLQELDRESQAAYSLELVAQDGGR----------------PP---RSATAALSV 233
           + A+LVL + LDRE QA +   L A DGG                 PP   R+ TA L++
Sbjct: 179 RFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTI 238

Query: 234 RVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEA 293
           RVLD+ND+ PAF Q  V  V L E++P G+L++ L+A DPDEG NG+VV++F +   P A
Sbjct: 239 RVLDSNDNVPAFDQ-PVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRA 297

Query: 294 RRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPD 353
           R LF L PR+GRL ++G +DYE    Y++ V+A+D GP    A CKV+VR+ D NDNAP+
Sbjct: 298 RELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPE 357

Query: 354 IAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVAL 413
           I+ + +                                         V EGAA  ++VAL
Sbjct: 358 ISFSTVK--------------------------------------EAVSEGAAPGTVVAL 379

Query: 414 VSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRG 473
            S +DRDS  NGQV+C L G   FRL+ ++   Y +VT A LDRE    Y LT+VA DRG
Sbjct: 380 FSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRG 439

Query: 474 APPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVT 533
            P L T +   V+V D NDNAP F++PVY+V V ENN PGAY+  V+A DRD G N Q+ 
Sbjct: 440 EPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLA 499

Query: 534 YRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQ-LSSS 592
           Y +LE ++   G +V TYVS++   G +YALRSFDYE L+    +++A D GSPQ L+ +
Sbjct: 500 YSILECQI--QGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGN 557

Query: 593 ALVQVRVLDQNDHAPVLVHPAPA-NGSLEVAVPGRTAK-DTVVARVQARDADEGANGELA 650
           A V + ++DQND+AP +V P P  NG+    V  R+A+   ++ RV A DAD+G N  L 
Sbjct: 558 ATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLT 617

Query: 651 FELQQQEPREAFAIGRRTGEILLTGDL-SQEPPGRVFRALLVISDGGRPPLTTTAT--VS 707
           + + +      F +  RTGE+     + ++  P R +  ++ + D G+PPL++TAT  V 
Sbjct: 618 YSIVRGNEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQ 677

Query: 708 FVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAI 767
            V  A   +G       GS E  RP  SR G  G     D  LI+II L     + L A+
Sbjct: 678 LVDGAVEPQGGGGSGGGGSGEHQRP--SRSG--GGETSLDLTLILIIALGSVSFIFLLAM 733

Query: 768 IAIATTCNRRKK 779
           I +A  C + KK
Sbjct: 734 IVLAVRCQKEKK 745


>gi|94538350 protocadherin 17 precursor [Homo sapiens]
          Length = 1159

 Score =  506 bits (1303), Expect = e-143
 Identities = 348/1013 (34%), Positives = 512/1013 (50%), Gaps = 138/1013 (13%)

Query: 30  KTVRYSTFEEDAPGTVIGTLAEDLHMKV------------SGDTSFRLMKQFNSSLLRVR 77
           K + YS  EE   GTVIG +  D  ++             S   S+R+++     LL V 
Sbjct: 19  KNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAPHLLDV- 77

Query: 78  EGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPR 137
           + D  L      +DRE LC    +C L+ +V +  +E   +  ++VE++D+ND+AP F  
Sbjct: 78  DADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKE---ICMIKVEIQDINDNAPSFSS 134

Query: 138 AQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLA-EPHSPFRVELQTRADGAQCAD 196
            QI +++SE AA GTR PL    D D G NGL+T  L  + H  F +++++R DG +  +
Sbjct: 135 DQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPE 194

Query: 197 LVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELA 256
           LV+ + LDRE Q  ++L L A DGG PPRSAT  ++V+V+D+ND+SP F   +   VEL 
Sbjct: 195 LVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYL-VELP 253

Query: 257 EDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYER 316
           E+AP+G++++DL+A D DEGPNG+V+++F +  P   R LF +DP++G + + G +DYE 
Sbjct: 254 ENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEE 313

Query: 317 QDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAA 376
               E+DV+A+D GP P  A CKV V++ D NDNAP I    +                 
Sbjct: 314 NGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQ--------------- 358

Query: 377 AALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYG--- 433
              G    ++P G                   +++ALV  +DRDSG NGQ++C + G   
Sbjct: 359 ---GALSEAAPPG-------------------TVIALVRVTDRDSGKNGQLQCRVLGGGG 396

Query: 434 ------------HEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVR 481
                          F+L+  Y   Y VVT   LDRE   EYN+T+VA D G+PPL + +
Sbjct: 397 TGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTK 456

Query: 482 PYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEV 541
            + +++ DENDN P FT+ +Y + V ENN PG YL +V A+D DLG+NG V+Y +L + +
Sbjct: 457 SFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHI 516

Query: 542 GRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSP-QLSSSALVQVRVL 600
           G    ++ TYVSV+P  GAIYALRSF++E  +  + ++ A D G+P  L S+A V+V VL
Sbjct: 517 GDV--SIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVL 574

Query: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE 660
           D ND+APV+V P   N + E+ VP       +V+ V+A D+D G +G L +E+       
Sbjct: 575 DVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDH 634

Query: 661 AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA 720
            F I   +GEI  T     E    V   ++ ++D G+P  T +A    ++ +  G  P  
Sbjct: 635 LFEIDPSSGEI-RTLHPFWEDVTPVVELVVKVTDHGKP--TLSAVAKLIIRSVSGSLP-- 689

Query: 721 PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
               G P           V+G    WD  L +I+ L+    +LLAA+I IA  C R  KE
Sbjct: 690 ---EGVPR----------VNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKE 736

Query: 781 VRKGGA-LREERPGAAGGGASAPG----------SPEEAARGAGPRPNMFDVLTFPGTGK 829
           +R     + E      GGG                 E   R A    N+ +V++ P    
Sbjct: 737 IRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNA---MNVMNVVSSPSLAT 793

Query: 830 APFGSPAADAPPPAVAAAEV----PGSEGGSA-TGESACH--FEGQQRLRGAHAEPYGAS 882
           +P         P +   +EV    P S   +   G + CH  F GQ    G +A    A+
Sbjct: 794 SPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQ----GTNASETPAT 849

Query: 883 P----GFGKEPAPPVAVWKGHSF--NTISGREAEKFSGKDSGKGDSDFNDSDSDIS---- 932
                     PA P  +     F  ++ + ++ E+ S +DSG GDSD  DSD D +    
Sbjct: 850 RMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSC 909

Query: 933 -----GDALKKDLINHMQSGLWA-------CTAECKILGHSDRCWSPSCSGPN 973
                 +ALK    +     L         CT EC++LGHSDRCW P     N
Sbjct: 910 CDMSVREALKMKTTSTKSQPLEQEPEECVNCTDECRVLGHSDRCWMPQFPAAN 962


>gi|157426847 protocadherin 19 isoform a [Homo sapiens]
          Length = 1101

 Score =  471 bits (1212), Expect = e-132
 Identities = 288/773 (37%), Positives = 432/773 (55%), Gaps = 75/773 (9%)

Query: 15  LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLH-----MKVSGDTSFRLMKQF 69
           L L ++ W  + A    ++YS  EE   GTVI  +A+D       +     ++FR++   
Sbjct: 9   LLLLAILWTQAAALIN-LKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67

Query: 70  NSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVN 129
              L+ +    G L V    +DR+ LC Q+P+C+++ +V+S S E   +  ++VE++D+N
Sbjct: 68  APHLVDINPSSG-LLVTKQKIDRDLLCRQSPKCIISLEVMSSSME---ICVIKVEIKDLN 123

Query: 130 DHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRA 189
           D+AP FP AQI +E+SE A+ GTRIPL+   D D G+ G+QT  L  P+  F +E++TR 
Sbjct: 124 DNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELT-PNELFGLEIKTRG 182

Query: 190 DGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGA 249
           DG++ A+LV+ + LDRE+Q+ YS  + A DGG PPR  T  LS++V D+ND++P F +  
Sbjct: 183 DGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSEST 242

Query: 250 VAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLA 309
            A V + E++P  + ++ L+A+DPDEG NG VV++F        R LF++DP SG +T+ 
Sbjct: 243 YA-VSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVT 301

Query: 310 GPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSP 369
           G +DYE    YELDV+A+D GP    A CKV V + D NDN P I +             
Sbjct: 302 GALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINL------------- 348

Query: 370 FAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRC 429
               +  + L     S+P G                    ++ALV  SDRDSG NG+V+C
Sbjct: 349 ---LSVNSELVEVSESAPPG-------------------YVIALVRVSDRDSGLNGRVQC 386

Query: 430 ALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGD 489
            L G+  FRLQ  Y     ++    LDRE+  +YNLT+ A D G P L++ + +TV + D
Sbjct: 387 RLLGNVPFRLQ-EYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITD 445

Query: 490 ENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVS 549
           ENDN P F++P Y+V V+ENN PGAYL +V+ARD DLG NG V+Y+++ ++V      V 
Sbjct: 446 ENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQV--RDMPVF 503

Query: 550 TYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVL 609
           TYVS++P +G IYALRSF++E  +  + ++ A DGG P L S+A V+V +LD ND+ PV+
Sbjct: 504 TYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVI 563

Query: 610 VHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTG 669
             P   NG+ EV +P  +    +V  V+A D DEG NG + +++ + + R  F I +  G
Sbjct: 564 TAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGD-RGFFEIDQVNG 622

Query: 670 EILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPER 729
           E+  T    +      +  ++V  D G+  L+ +A V   ++      PA  A       
Sbjct: 623 EVRTTRTFGESSKSS-YELIVVAHDHGKTSLSASALVLIYLS------PALDAQES---- 671

Query: 730 SRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVR 782
                      GSV   +  LI II L     +L   +I +A  C R  KE+R
Sbjct: 672 ----------MGSV---NLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIR 711



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 32/88 (36%), Positives = 42/88 (47%), Gaps = 16/88 (18%)

Query: 907 REAEKFSGKDSGKGDSDFNDSDSDISG----DALKKDLIN------------HMQSGLWA 950
           ++ E  S KDSG  +SD  DS+ D+      D    D++N            H Q+  + 
Sbjct: 850 KDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFH 909

Query: 951 CTAECKILGHSDRCWSPSCSGPNAHPSP 978
           C  EC+ILGHSDRCW P    P    SP
Sbjct: 910 CREECRILGHSDRCWMPRNPMPIRSKSP 937


>gi|157426845 protocadherin 19 isoform b [Homo sapiens]
          Length = 1100

 Score =  471 bits (1212), Expect = e-132
 Identities = 288/773 (37%), Positives = 432/773 (55%), Gaps = 75/773 (9%)

Query: 15  LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLH-----MKVSGDTSFRLMKQF 69
           L L ++ W  + A    ++YS  EE   GTVI  +A+D       +     ++FR++   
Sbjct: 9   LLLLAILWTQAAALIN-LKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNS 67

Query: 70  NSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVN 129
              L+ +    G L V    +DR+ LC Q+P+C+++ +V+S S E   +  ++VE++D+N
Sbjct: 68  APHLVDINPSSG-LLVTKQKIDRDLLCRQSPKCIISLEVMSSSME---ICVIKVEIKDLN 123

Query: 130 DHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRA 189
           D+AP FP AQI +E+SE A+ GTRIPL+   D D G+ G+QT  L  P+  F +E++TR 
Sbjct: 124 DNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELT-PNELFGLEIKTRG 182

Query: 190 DGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGA 249
           DG++ A+LV+ + LDRE+Q+ YS  + A DGG PPR  T  LS++V D+ND++P F +  
Sbjct: 183 DGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSEST 242

Query: 250 VAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLA 309
            A V + E++P  + ++ L+A+DPDEG NG VV++F        R LF++DP SG +T+ 
Sbjct: 243 YA-VSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVT 301

Query: 310 GPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSP 369
           G +DYE    YELDV+A+D GP    A CKV V + D NDN P I +             
Sbjct: 302 GALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINL------------- 348

Query: 370 FAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRC 429
               +  + L     S+P G                    ++ALV  SDRDSG NG+V+C
Sbjct: 349 ---LSVNSELVEVSESAPPG-------------------YVIALVRVSDRDSGLNGRVQC 386

Query: 430 ALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGD 489
            L G+  FRLQ  Y     ++    LDRE+  +YNLT+ A D G P L++ + +TV + D
Sbjct: 387 RLLGNVPFRLQ-EYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITD 445

Query: 490 ENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVS 549
           ENDN P F++P Y+V V+ENN PGAYL +V+ARD DLG NG V+Y+++ ++V      V 
Sbjct: 446 ENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQV--RDMPVF 503

Query: 550 TYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVL 609
           TYVS++P +G IYALRSF++E  +  + ++ A DGG P L S+A V+V +LD ND+ PV+
Sbjct: 504 TYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVI 563

Query: 610 VHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTG 669
             P   NG+ EV +P  +    +V  V+A D DEG NG + +++ + + R  F I +  G
Sbjct: 564 TAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGD-RGFFEIDQVNG 622

Query: 670 EILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPER 729
           E+  T    +      +  ++V  D G+  L+ +A V   ++      PA  A       
Sbjct: 623 EVRTTRTFGESSKSS-YELIVVAHDHGKTSLSASALVLIYLS------PALDAQES---- 671

Query: 730 SRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVR 782
                      GSV   +  LI II L     +L   +I +A  C R  KE+R
Sbjct: 672 ----------MGSV---NLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIR 711



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 33/98 (33%), Positives = 46/98 (46%), Gaps = 16/98 (16%)

Query: 897 KGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISG----DALKKDLIN---------- 942
           + H   + + ++ E  S KDSG  +SD  DS+ D+      D    D++N          
Sbjct: 839 RAHLIKSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQM 898

Query: 943 --HMQSGLWACTAECKILGHSDRCWSPSCSGPNAHPSP 978
             H Q+  + C  EC+ILGHSDRCW P    P    SP
Sbjct: 899 PDHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSP 936


>gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precursor
           [Homo sapiens]
          Length = 1007

 Score =  448 bits (1153), Expect = e-125
 Identities = 271/704 (38%), Positives = 391/704 (55%), Gaps = 53/704 (7%)

Query: 12  LFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVS----GDTSFRLMK 67
           L PL L  L  +   A S+ +RYS  EE APG ++G +A  L +++     G      + 
Sbjct: 25  LLPLLLLLLLLLPGPAASQ-LRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRINHLG 83

Query: 68  QFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRD 127
             +   L +    G L V +  +DRE LC Q P+C+L+ +V++ +     +  VEVE+ D
Sbjct: 84  APSPRYLELDLTSGALFVNER-IDREALCEQRPRCLLSLEVLAHNP--VAVSAVEVEILD 140

Query: 128 VNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQT 187
           +ND++PRFPR    ++VSE  A G R  +E   D DVGAN +QT  L+ P   F ++L+ 
Sbjct: 141 INDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELS-PSEHFELDLKP 199

Query: 188 RADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247
             + ++  +LVL + LDRE  A + L L A DGG P RS TA +SVRVLD ND+SPAF Q
Sbjct: 200 LQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQ 259

Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLT 307
                V+L ED+P G+L++ L+A+DPDEG NG++ ++  + T    R+LF +D  +G + 
Sbjct: 260 STY-RVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVR 318

Query: 308 LAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPAT 367
           + G +DYE   +Y++ V+A DRGP P A  CKV+V I DVNDNAP++ +T L +P     
Sbjct: 319 VIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSP----- 373

Query: 368 SPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQV 427
                                            VPE A   ++VA++S +D+DSG N +V
Sbjct: 374 ---------------------------------VPENATPNTIVAVLSVNDQDSGPNRKV 400

Query: 428 RCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRV 487
              L     FRL   +  SY +V +  LDRER+A YN+T+ A D G P L ++R   V +
Sbjct: 401 SLGLEATLPFRLN-GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEI 459

Query: 488 GDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGA 547
            D NDN P F    Y + ++ENN PG  L TV A D D   N +VTY LLE E+   G  
Sbjct: 460 SDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREI--QGLP 517

Query: 548 VSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAP 607
           V++YVS++ A+G++YA+ SFDYE  R+  V ++A D GSP LSS+    V V+D NDHAP
Sbjct: 518 VTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAP 577

Query: 608 VLVHPAPANGSLEVAVPGRTA-KDTVVARVQARDADEGANGELAFELQQQEPREAFAIGR 666
            +++P   N S    +  RTA    +V +V A D+D G N  L + L Q    + F +  
Sbjct: 578 HILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVEL 637

Query: 667 RTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVV 710
            TGEI  T  +  E  G  F   +V+ D G P L+ +  ++  V
Sbjct: 638 HTGEIRTTRKMGDE-SGSTFNLTVVVRDNGEPSLSASVAITVAV 680



 Score =  138 bits (347), Expect = 3e-32
 Identities = 157/603 (26%), Positives = 254/603 (42%), Gaps = 91/603 (15%)

Query: 137 RAQIPVEVSEGAAVGT---RIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQ 193
           R  +P E + GA VG     + LE+     +G   L+   L  P SP  +EL   +    
Sbjct: 45  RYSVPEEQAPGALVGNVARALGLEL---RRLGPGCLRINHLGAP-SPRYLELDLTSGA-- 98

Query: 194 CADLVLLQELDRES------QAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247
              L + + +DRE+      +   SLE++A +       A +A+ V +LD ND+SP FP+
Sbjct: 99  ---LFVNERIDREALCEQRPRCLLSLEVLAHNP-----VAVSAVEVEILDINDNSPRFPR 150

Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRL----FRLDPRS 303
               +++++E    G+      A DPD G N    +     +P E   L     + + + 
Sbjct: 151 PNY-QLQVSESVAPGARFHIESAQDPDVGANSVQTYEL---SPSEHFELDLKPLQENSKV 206

Query: 304 GRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPG 363
             L L   +D E+   + L + A D G   R+ T ++ VR+ D NDN+P           
Sbjct: 207 LELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSP----------- 255

Query: 364 APATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGA 423
                 F  +     L      SP G                   +LV  ++ SD D G+
Sbjct: 256 -----AFDQSTYRVQLR---EDSPPG-------------------TLVVKLNASDPDEGS 288

Query: 424 NGQVRCALYGHEHFRLQPAY---AGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480
           NG++R +L  +   R +  +   A +  V     LD E  + Y + + A DRG  P+   
Sbjct: 289 NGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGH 348

Query: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540
               V + D NDNAP          V EN  P   +A ++  D+D G N +V+  L    
Sbjct: 349 CKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATL 408

Query: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600
             R  G  ++Y  V   +G +      D E +   ++ + A+DGG PQL+S   ++V + 
Sbjct: 409 PFRLNGFGNSYTLV--VSGPL------DRERVAVYNITVTATDGGIPQLTSLRTLKVEIS 460

Query: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--- 657
           D ND+ P  +  + +    E  +PG      ++  VQA D DE  N E+ + L ++E   
Sbjct: 461 DINDNPPSFLEDSYSIYIQENNLPG-----VLLCTVQATDPDEKENAEVTYSLLEREIQG 515

Query: 658 -PREAF-AIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGG 715
            P  ++ +I   +G +        E   R F   +   D G PPL++T T +  V     
Sbjct: 516 LPVTSYVSINSASGSLYAVNSFDYEK-FREFFVTVEAQDKGSPPLSSTVTANVYVVDMND 574

Query: 716 RGP 718
             P
Sbjct: 575 HAP 577



 Score =  111 bits (277), Expect = 4e-24
 Identities = 102/371 (27%), Positives = 151/371 (40%), Gaps = 41/371 (11%)

Query: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180
           V V++ DVND+AP      +   V E A   T + +    D+D G N   ++ L E   P
Sbjct: 351 VLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGL-EATLP 409

Query: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240
           FR+             LV+   LDRE  A Y++ + A DGG P  ++   L V + D ND
Sbjct: 410 FRLN-----GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDIND 464

Query: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPP--EARRLFR 298
           + P+F + + + + + E+   G LL  + A DPDE  N +V ++   R            
Sbjct: 465 NPPSFLEDSYS-IYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVS 523

Query: 299 LDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITP 358
           ++  SG L      DYE+   + + V AQD+G  P ++T    V + D+ND+AP I    
Sbjct: 524 INSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYP- 582

Query: 359 LAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSD 418
                                            T  + A  +VP  A    LV  V   D
Sbjct: 583 -------------------------------TSTNSSAAFEMVPRTAPAGYLVTKVIAMD 611

Query: 419 RDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLR 478
            DSG N  +   L       L      +  + T   +  E  + +NLT+V  D G P L 
Sbjct: 612 SDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLS 671

Query: 479 TVRPYTVRVGD 489
                TV V D
Sbjct: 672 ASVAITVAVVD 682



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 43/161 (26%), Positives = 67/161 (41%), Gaps = 39/161 (24%)

Query: 106 FDVVSFSQEQFRLVHVEVEVRD------------------VNDHAPRFPRAQIPVEVSEG 147
           + V SF  E+FR   V VE +D                  +NDHAP       P   +  
Sbjct: 532 YAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHI---LYPTSTNSS 588

Query: 148 AA---------VGTRIPLEVPVDEDVGANGLQTVRLAEPH--SPFRVELQTRADGAQCAD 196
           AA          G  +   + +D D G N      LA+      F+VEL T        +
Sbjct: 589 AAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHT-------GE 641

Query: 197 LVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLD 237
           +   +++  ES + ++L +V +D G P  SA+ A++V V+D
Sbjct: 642 IRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682


>gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precursor
           [Homo sapiens]
          Length = 884

 Score =  448 bits (1153), Expect = e-125
 Identities = 271/704 (38%), Positives = 391/704 (55%), Gaps = 53/704 (7%)

Query: 12  LFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVS----GDTSFRLMK 67
           L PL L  L  +   A S+ +RYS  EE APG ++G +A  L +++     G      + 
Sbjct: 25  LLPLLLLLLLLLPGPAASQ-LRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRINHLG 83

Query: 68  QFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRD 127
             +   L +    G L V +  +DRE LC Q P+C+L+ +V++ +     +  VEVE+ D
Sbjct: 84  APSPRYLELDLTSGALFVNER-IDREALCEQRPRCLLSLEVLAHNP--VAVSAVEVEILD 140

Query: 128 VNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQT 187
           +ND++PRFPR    ++VSE  A G R  +E   D DVGAN +QT  L+ P   F ++L+ 
Sbjct: 141 INDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELS-PSEHFELDLKP 199

Query: 188 RADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247
             + ++  +LVL + LDRE  A + L L A DGG P RS TA +SVRVLD ND+SPAF Q
Sbjct: 200 LQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQ 259

Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLT 307
                V+L ED+P G+L++ L+A+DPDEG NG++ ++  + T    R+LF +D  +G + 
Sbjct: 260 STY-RVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVR 318

Query: 308 LAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPAT 367
           + G +DYE   +Y++ V+A DRGP P A  CKV+V I DVNDNAP++ +T L +P     
Sbjct: 319 VIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSP----- 373

Query: 368 SPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQV 427
                                            VPE A   ++VA++S +D+DSG N +V
Sbjct: 374 ---------------------------------VPENATPNTIVAVLSVNDQDSGPNRKV 400

Query: 428 RCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRV 487
              L     FRL   +  SY +V +  LDRER+A YN+T+ A D G P L ++R   V +
Sbjct: 401 SLGLEATLPFRLN-GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEI 459

Query: 488 GDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGA 547
            D NDN P F    Y + ++ENN PG  L TV A D D   N +VTY LLE E+   G  
Sbjct: 460 SDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREI--QGLP 517

Query: 548 VSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAP 607
           V++YVS++ A+G++YA+ SFDYE  R+  V ++A D GSP LSS+    V V+D NDHAP
Sbjct: 518 VTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAP 577

Query: 608 VLVHPAPANGSLEVAVPGRTA-KDTVVARVQARDADEGANGELAFELQQQEPREAFAIGR 666
            +++P   N S    +  RTA    +V +V A D+D G N  L + L Q    + F +  
Sbjct: 578 HILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVEL 637

Query: 667 RTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVV 710
            TGEI  T  +  E  G  F   +V+ D G P L+ +  ++  V
Sbjct: 638 HTGEIRTTRKMGDE-SGSTFNLTVVVRDNGEPSLSASVAITVAV 680



 Score =  138 bits (347), Expect = 3e-32
 Identities = 157/603 (26%), Positives = 254/603 (42%), Gaps = 91/603 (15%)

Query: 137 RAQIPVEVSEGAAVGT---RIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQ 193
           R  +P E + GA VG     + LE+     +G   L+   L  P SP  +EL   +    
Sbjct: 45  RYSVPEEQAPGALVGNVARALGLEL---RRLGPGCLRINHLGAP-SPRYLELDLTSGA-- 98

Query: 194 CADLVLLQELDRES------QAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247
              L + + +DRE+      +   SLE++A +       A +A+ V +LD ND+SP FP+
Sbjct: 99  ---LFVNERIDREALCEQRPRCLLSLEVLAHNP-----VAVSAVEVEILDINDNSPRFPR 150

Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRL----FRLDPRS 303
               +++++E    G+      A DPD G N    +     +P E   L     + + + 
Sbjct: 151 PNY-QLQVSESVAPGARFHIESAQDPDVGANSVQTYEL---SPSEHFELDLKPLQENSKV 206

Query: 304 GRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPG 363
             L L   +D E+   + L + A D G   R+ T ++ VR+ D NDN+P           
Sbjct: 207 LELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSP----------- 255

Query: 364 APATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGA 423
                 F  +     L      SP G                   +LV  ++ SD D G+
Sbjct: 256 -----AFDQSTYRVQLR---EDSPPG-------------------TLVVKLNASDPDEGS 288

Query: 424 NGQVRCALYGHEHFRLQPAY---AGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV 480
           NG++R +L  +   R +  +   A +  V     LD E  + Y + + A DRG  P+   
Sbjct: 289 NGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGH 348

Query: 481 RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE 540
               V + D NDNAP          V EN  P   +A ++  D+D G N +V+  L    
Sbjct: 349 CKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATL 408

Query: 541 VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL 600
             R  G  ++Y  V   +G +      D E +   ++ + A+DGG PQL+S   ++V + 
Sbjct: 409 PFRLNGFGNSYTLV--VSGPL------DRERVAVYNITVTATDGGIPQLTSLRTLKVEIS 460

Query: 601 DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--- 657
           D ND+ P  +  + +    E  +PG      ++  VQA D DE  N E+ + L ++E   
Sbjct: 461 DINDNPPSFLEDSYSIYIQENNLPG-----VLLCTVQATDPDEKENAEVTYSLLEREIQG 515

Query: 658 -PREAF-AIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGG 715
            P  ++ +I   +G +        E   R F   +   D G PPL++T T +  V     
Sbjct: 516 LPVTSYVSINSASGSLYAVNSFDYEK-FREFFVTVEAQDKGSPPLSSTVTANVYVVDMND 574

Query: 716 RGP 718
             P
Sbjct: 575 HAP 577



 Score =  111 bits (277), Expect = 4e-24
 Identities = 102/371 (27%), Positives = 151/371 (40%), Gaps = 41/371 (11%)

Query: 121 VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP 180
           V V++ DVND+AP      +   V E A   T + +    D+D G N   ++ L E   P
Sbjct: 351 VLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGL-EATLP 409

Query: 181 FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND 240
           FR+             LV+   LDRE  A Y++ + A DGG P  ++   L V + D ND
Sbjct: 410 FRLN-----GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDIND 464

Query: 241 HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPP--EARRLFR 298
           + P+F + + + + + E+   G LL  + A DPDE  N +V ++   R            
Sbjct: 465 NPPSFLEDSYS-IYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVS 523

Query: 299 LDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITP 358
           ++  SG L      DYE+   + + V AQD+G  P ++T    V + D+ND+AP I    
Sbjct: 524 INSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYP- 582

Query: 359 LAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSD 418
                                            T  + A  +VP  A    LV  V   D
Sbjct: 583 -------------------------------TSTNSSAAFEMVPRTAPAGYLVTKVIAMD 611

Query: 419 RDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLR 478
            DSG N  +   L       L      +  + T   +  E  + +NLT+V  D G P L 
Sbjct: 612 SDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLS 671

Query: 479 TVRPYTVRVGD 489
                TV V D
Sbjct: 672 ASVAITVAVVD 682



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 43/161 (26%), Positives = 67/161 (41%), Gaps = 39/161 (24%)

Query: 106 FDVVSFSQEQFRLVHVEVEVRD------------------VNDHAPRFPRAQIPVEVSEG 147
           + V SF  E+FR   V VE +D                  +NDHAP       P   +  
Sbjct: 532 YAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHI---LYPTSTNSS 588

Query: 148 AA---------VGTRIPLEVPVDEDVGANGLQTVRLAEPH--SPFRVELQTRADGAQCAD 196
           AA          G  +   + +D D G N      LA+      F+VEL T        +
Sbjct: 589 AAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHT-------GE 641

Query: 197 LVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLD 237
           +   +++  ES + ++L +V +D G P  SA+ A++V V+D
Sbjct: 642 IRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682


>gi|7706113 protocadherin 12 precursor [Homo sapiens]
          Length = 1184

 Score =  446 bits (1146), Expect = e-125
 Identities = 280/787 (35%), Positives = 425/787 (54%), Gaps = 104/787 (13%)

Query: 31  TVRYSTFEEDAPGTVIGTLAEDL---HMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGD 87
           TV+Y   EE   GTVIG L+++L     +     +F++++   +  ++V   +G L+ G 
Sbjct: 31  TVKYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQLPQALPIQVDSEEGLLSTGR 90

Query: 88  AGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEG 147
             LDRE+LC Q   C+++FDV++       L+HVE++V D+NDH PRFP+ +  +E+SE 
Sbjct: 91  R-LDREQLCRQWDPCLVSFDVLATGD--LALIHVEIQVLDINDHQPRFPKGEQELEISES 147

Query: 148 AAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRES 207
           A++ TRIPL+  +D D G N L T  L+ P   F +++    D  + A+L++++ELDRE 
Sbjct: 148 ASLRTRIPLDRALDPDTGPNTLHTYTLS-PSEHFALDVIVGPDETKHAELIVVKELDREI 206

Query: 208 QAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLD 267
            + + L L A D G PP+S T+ + V VLD+ND+SPAF + ++A +E+ EDA  G+LL+ 
Sbjct: 207 HSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLA-LEIQEDAAPGTLLIK 265

Query: 268 LDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQ 327
           L A DPD+GPNG+V F      PPE    F +D ++G++ L  P+DYE+   YE+DV+A+
Sbjct: 266 LTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQAR 325

Query: 328 DRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSP 387
           D GP P  A CKV++++ DVNDN P I +T  + P                         
Sbjct: 326 DLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQP------------------------- 360

Query: 388 AGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGH-EHFRLQPAYAGS 446
                      SLV E   ++S +ALV   D DSG NG V C L     HFRL+     +
Sbjct: 361 -----------SLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGNT 409

Query: 447 YLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSV 506
           Y+++T A+LDRE+  +Y LTL+A+D+G  PL   +  ++++ D NDNAP+F +  YEVS 
Sbjct: 410 YMLLTNATLDREQWPKYTLTLLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVST 469

Query: 507 RENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRS 566
           RENN P  +L T+ A D DLG NG+V+YR+ ++ V          V++D  TG + A RS
Sbjct: 470 RENNLPSLHLITIKAHDADLGINGKVSYRIQDSPVAH-------LVAIDSNTGEVTAQRS 522

Query: 567 FDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANG--SLEVAVP 624
            +YE +   + ++ A D G P L+SS  V V +LD ND+AP +V P  ++G  SL V V 
Sbjct: 523 LNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVN 582

Query: 625 GRT---------------------------AKDTVVARVQARDADEGANGELAFELQQQE 657
             T                           ++  ++  + ARDAD GANGE  + ++   
Sbjct: 583 ASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIVARDADSGANGEPLYSIRSGN 642

Query: 658 PREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTA--TVSFVVTAGGG 715
               F +   TG++ +    +    G  +   +V+ D G PPL T A   V FV +    
Sbjct: 643 EAHLFILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFVTSVDHL 702

Query: 716 RGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
           R           + +R PG+   +S S+L     +I + VL G   L+LA  ++I   C 
Sbjct: 703 R-----------DSARKPGA---LSMSML----TVICLAVLLGIFGLILALFMSI---CR 741

Query: 776 RRKKEVR 782
             KK+ R
Sbjct: 742 TEKKDNR 748


>gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precursor
           [Homo sapiens]
          Length = 871

 Score =  439 bits (1130), Expect = e-123
 Identities = 271/748 (36%), Positives = 399/748 (53%), Gaps = 64/748 (8%)

Query: 32  VRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMK--QFNSSLLRVREGDGQLTVGDAG 89
           +RY   EE   GT +G +A+D  +     ++ RL    + N    RV    G L + +  
Sbjct: 31  IRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNP- 89

Query: 90  LDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAA 149
           +DRE LCG +  C++  + V+  +    +   EVE+ DVNDHAPRFPR Q+ +E+ E A 
Sbjct: 90  IDREALCGLSASCIVPLEFVT--EGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAP 147

Query: 150 VGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQA 209
            G R PLE   D DVG+N + + RL+  +  F ++++ R+DG+   +L+L + LDRE Q+
Sbjct: 148 PGQRFPLEKAQDADVGSNSISSYRLSS-NEHFALDVKKRSDGSLVPELLLEKPLDREKQS 206

Query: 210 AYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLD 269
            Y L L A DGG PPRS TA L V VLD ND++PAF Q +   + + E AP G +L+ L+
Sbjct: 207 DYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY-RISVLESAPAGMVLIQLN 265

Query: 270 AADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDR 329
           A+DPD GP+G+V F F   TP   R LF L P +G+LTL GP+D+E ++ YE DVRA+D 
Sbjct: 266 ASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDG 325

Query: 330 GPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAG 389
           G       C + V + DVNDNAP I +T                   + LG         
Sbjct: 326 GSPAMEQHCSLRVDLLDVNDNAPYITVT-------------------SELG--------- 357

Query: 390 AGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLV 449
                      +PE A   ++VAL+S  D DSG+NG V   +  H  F L+ A+   + +
Sbjct: 358 ----------TLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSL 407

Query: 450 VTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVREN 509
           VTA  LDRE  + Y++ + A D G PPL T R   + + D NDN P F +  +EV V EN
Sbjct: 408 VTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPEN 467

Query: 510 NPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDY 569
           N PG  L ++AA D D G N  ++Y LLE        + S+++S++P TGA++A RSFDY
Sbjct: 468 NRPGDLLCSLAASDPDSGLNALISYSLLEPR--NRDVSASSFISLNPQTGAVHATRSFDY 525

Query: 570 ETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSL-EVAVPGRTA 628
           E  + L   +QA D G+P LSS+  V++ VLD ND+AP ++ P    GSL   A+P    
Sbjct: 526 EQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVG 585

Query: 629 KDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRA 688
              ++ +V A D D G N  ++++L +      FA+ R  GE+     +  + P +  + 
Sbjct: 586 AGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQ--KL 643

Query: 689 LLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDT 748
           ++V+ D G PPL+T+ T+  +V+      P  P    S    R   SRL           
Sbjct: 644 VIVVKDSGSPPLSTSVTL--LVSLEEDTHPVVPDLRES-SAPREGESRL----------- 689

Query: 749 PLIVIIVLAGSCTLLLAAIIAIATTCNR 776
            L + + L   C +   + +A+ + C R
Sbjct: 690 TLYLAVSLVAICFVSFGSFVALLSKCLR 717


>gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precursor
           [Homo sapiens]
          Length = 938

 Score =  439 bits (1130), Expect = e-123
 Identities = 271/748 (36%), Positives = 399/748 (53%), Gaps = 64/748 (8%)

Query: 32  VRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMK--QFNSSLLRVREGDGQLTVGDAG 89
           +RY   EE   GT +G +A+D  +     ++ RL    + N    RV    G L + +  
Sbjct: 31  IRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNP- 89

Query: 90  LDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAA 149
           +DRE LCG +  C++  + V+  +    +   EVE+ DVNDHAPRFPR Q+ +E+ E A 
Sbjct: 90  IDREALCGLSASCIVPLEFVT--EGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAP 147

Query: 150 VGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQA 209
            G R PLE   D DVG+N + + RL+  +  F ++++ R+DG+   +L+L + LDRE Q+
Sbjct: 148 PGQRFPLEKAQDADVGSNSISSYRLSS-NEHFALDVKKRSDGSLVPELLLEKPLDREKQS 206

Query: 210 AYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLD 269
            Y L L A DGG PPRS TA L V VLD ND++PAF Q +   + + E AP G +L+ L+
Sbjct: 207 DYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY-RISVLESAPAGMVLIQLN 265

Query: 270 AADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDR 329
           A+DPD GP+G+V F F   TP   R LF L P +G+LTL GP+D+E ++ YE DVRA+D 
Sbjct: 266 ASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDG 325

Query: 330 GPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAG 389
           G       C + V + DVNDNAP I +T                   + LG         
Sbjct: 326 GSPAMEQHCSLRVDLLDVNDNAPYITVT-------------------SELG--------- 357

Query: 390 AGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLV 449
                      +PE A   ++VAL+S  D DSG+NG V   +  H  F L+ A+   + +
Sbjct: 358 ----------TLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSL 407

Query: 450 VTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVREN 509
           VTA  LDRE  + Y++ + A D G PPL T R   + + D NDN P F +  +EV V EN
Sbjct: 408 VTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPEN 467

Query: 510 NPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDY 569
           N PG  L ++AA D D G N  ++Y LLE        + S+++S++P TGA++A RSFDY
Sbjct: 468 NRPGDLLCSLAASDPDSGLNALISYSLLEPR--NRDVSASSFISLNPQTGAVHATRSFDY 525

Query: 570 ETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSL-EVAVPGRTA 628
           E  + L   +QA D G+P LSS+  V++ VLD ND+AP ++ P    GSL   A+P    
Sbjct: 526 EQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVG 585

Query: 629 KDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRA 688
              ++ +V A D D G N  ++++L +      FA+ R  GE+     +  + P +  + 
Sbjct: 586 AGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQ--KL 643

Query: 689 LLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDT 748
           ++V+ D G PPL+T+ T+  +V+      P  P    S    R   SRL           
Sbjct: 644 VIVVKDSGSPPLSTSVTL--LVSLEEDTHPVVPDLRES-SAPREGESRL----------- 689

Query: 749 PLIVIIVLAGSCTLLLAAIIAIATTCNR 776
            L + + L   C +   + +A+ + C R
Sbjct: 690 TLYLAVSLVAICFVSFGSFVALLSKCLR 717


>gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo
           sapiens]
          Length = 807

 Score =  439 bits (1129), Expect = e-123
 Identities = 298/851 (35%), Positives = 442/851 (51%), Gaps = 87/851 (10%)

Query: 14  PLQLFSLCWVLSVAQSKT----VRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMK 67
           P QL  L W+L +A  +T    + YS  EE   GT +G +A+DL ++++      FR+  
Sbjct: 11  PRQL--LLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVAS 68

Query: 68  QFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRD 127
           + +  LL V   +G L V ++ +DRE LCG++ +C +  +V+       ++ HVEV+VRD
Sbjct: 69  KRHGDLLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVFHVEVKVRD 125

Query: 128 VNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQT 187
           +ND+ P FP ++  + ++E     TR PL+   D D+G N   T RL +P+  F ++ Q 
Sbjct: 126 INDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRL-DPNDYFTLDAQN 184

Query: 188 RADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247
             +      LVL + LDRE    +SL L A DGG+P  + T  L + +LD ND++P F Q
Sbjct: 185 SLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQ 244

Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLT 307
            +V +V + E+A  G+L++ L+A DPD+G NGD+V++F     P     F ++P +G + 
Sbjct: 245 -SVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIR 303

Query: 308 LAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPAT 367
             G +D+E +  YE+ V A D+G  P A  C ++V + DVNDNAP++ IT L+ P    T
Sbjct: 304 TKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDT 363

Query: 368 SPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQV 427
            P A                                      ++AL+S SDRDSG+NGQV
Sbjct: 364 QPSA--------------------------------------IIALISVSDRDSGSNGQV 385

Query: 428 RCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRV 487
            C L  H  F+L   Y   Y +V  ++LDRE ++ Y L + A D G+P L      +V V
Sbjct: 386 TCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGV 445

Query: 488 GDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGA 547
            D NDNAP F +P Y V V+ENNPPG ++ TV+A+D D   N  V+Y L+E  VG    A
Sbjct: 446 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGER--A 503

Query: 548 VSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAP 607
           +S+YVSV   +G +YAL+  D+E L  L  ++ A D G P L S+  +QV VLD+ND+AP
Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAP 563

Query: 608 VLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREAFA 663
            L+ P    A G++   +P       VVA+V+A DAD G N  L++ELQ      R  F 
Sbjct: 564 ALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFR 623

Query: 664 IGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPAS 723
           +G  TGEI  T  L  E      R L+++ D G P LT TATV   +   G     AP +
Sbjct: 624 VGLYTGEISTTRPL-DEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESG----QAPQA 678

Query: 724 AGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRK 783
           +     SR     +G   +++  +  LI I + A S  L+L  ++  A  C+    E   
Sbjct: 679 S-----SRASAGAVGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSAPPTE--- 729

Query: 784 GGALREERPGAAGGGASAPGSPEEAARG---AGPRPNMFDVLTFPGTGKAPFGSPAADAP 840
            GA    +P      A+   S  +  R    +G  P+  D++ F         SP+    
Sbjct: 730 -GACAPGKPTLVCSSAAGSWSYSQQRRPRVCSGEGPHKTDLMAF---------SPSL--- 776

Query: 841 PPAVAAAEVPG 851
           PP + +AE  G
Sbjct: 777 PPCLGSAEGTG 787


>gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo
           sapiens]
          Length = 950

 Score =  439 bits (1129), Expect = e-123
 Identities = 298/851 (35%), Positives = 442/851 (51%), Gaps = 87/851 (10%)

Query: 14  PLQLFSLCWVLSVAQSKT----VRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMK 67
           P QL  L W+L +A  +T    + YS  EE   GT +G +A+DL ++++      FR+  
Sbjct: 11  PRQL--LLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVAS 68

Query: 68  QFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRD 127
           + +  LL V   +G L V ++ +DRE LCG++ +C +  +V+       ++ HVEV+VRD
Sbjct: 69  KRHGDLLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVFHVEVKVRD 125

Query: 128 VNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQT 187
           +ND+ P FP ++  + ++E     TR PL+   D D+G N   T RL +P+  F ++ Q 
Sbjct: 126 INDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRL-DPNDYFTLDAQN 184

Query: 188 RADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQ 247
             +      LVL + LDRE    +SL L A DGG+P  + T  L + +LD ND++P F Q
Sbjct: 185 SLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQ 244

Query: 248 GAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLT 307
            +V +V + E+A  G+L++ L+A DPD+G NGD+V++F     P     F ++P +G + 
Sbjct: 245 -SVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIR 303

Query: 308 LAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPAT 367
             G +D+E +  YE+ V A D+G  P A  C ++V + DVNDNAP++ IT L+ P    T
Sbjct: 304 TKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDT 363

Query: 368 SPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQV 427
            P A                                      ++AL+S SDRDSG+NGQV
Sbjct: 364 QPSA--------------------------------------IIALISVSDRDSGSNGQV 385

Query: 428 RCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRV 487
            C L  H  F+L   Y   Y +V  ++LDRE ++ Y L + A D G+P L      +V V
Sbjct: 386 TCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGV 445

Query: 488 GDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGA 547
            D NDNAP F +P Y V V+ENNPPG ++ TV+A+D D   N  V+Y L+E  VG    A
Sbjct: 446 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGER--A 503

Query: 548 VSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAP 607
           +S+YVSV   +G +YAL+  D+E L  L  ++ A D G P L S+  +QV VLD+ND+AP
Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAP 563

Query: 608 VLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREAFA 663
            L+ P    A G++   +P       VVA+V+A DAD G N  L++ELQ      R  F 
Sbjct: 564 ALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFR 623

Query: 664 IGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPAS 723
           +G  TGEI  T  L  E      R L+++ D G P LT TATV   +   G     AP +
Sbjct: 624 VGLYTGEISTTRPL-DEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESG----QAPQA 678

Query: 724 AGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRK 783
           +     SR     +G   +++  +  LI I + A S  L+L  ++  A  C+    E   
Sbjct: 679 S-----SRASAGAVGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSAPPTE--- 729

Query: 784 GGALREERPGAAGGGASAPGSPEEAARG---AGPRPNMFDVLTFPGTGKAPFGSPAADAP 840
            GA    +P      A+   S  +  R    +G  P+  D++ F         SP+    
Sbjct: 730 -GACAPGKPTLVCSSAAGSWSYSQQRRPRVCSGEGPHKTDLMAF---------SPSL--- 776

Query: 841 PPAVAAAEVPG 851
           PP + +AE  G
Sbjct: 777 PPCLGSAEGTG 787


>gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo
           sapiens]
          Length = 814

 Score =  438 bits (1126), Expect = e-122
 Identities = 292/818 (35%), Positives = 426/818 (52%), Gaps = 74/818 (9%)

Query: 8   GSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRL 65
           GS  L  L L    W +   Q   + YS  EE   GT +G +A+DL ++++      FR+
Sbjct: 10  GSWRLLLLLLLLAAWKVGSGQ---LHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRV 66

Query: 66  MKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEV 125
             + +  LL V   +G L V ++ +DRE LCG++ +C +  +V+       ++ HV+VEV
Sbjct: 67  ASKRHRDLLEVSLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVFHVDVEV 123

Query: 126 RDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVEL 185
           +DVND+ P F      + VSE     +R PLE   D DVGAN + T RL+  H  F +++
Sbjct: 124 KDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSS-HDYFMLDV 182

Query: 186 QTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAF 245
            ++ D  +  +LVL + LDRE   A+ L L A DGG+P  + T  L V VLD ND++P F
Sbjct: 183 NSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTF 242

Query: 246 PQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGR 305
            Q    EV + E+A  G+ ++ L+A+DPDEG NG + ++F +         F +D  +G 
Sbjct: 243 EQSEY-EVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGE 301

Query: 306 LTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAP 365
           + + G +D+E+++ Y++ + A D+G  P A  C V+VRI D NDN P+IA+T L+ P   
Sbjct: 302 IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLP--- 358

Query: 366 ATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANG 425
                                              V E A   +++AL+S +D DSGANG
Sbjct: 359 -----------------------------------VREDAQFGTVIALISVNDLDSGANG 383

Query: 426 QVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTV 485
           QV C+L  H  F+L   +   Y +V  ++LDRER++ Y L + A D G+P L      +V
Sbjct: 384 QVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSV 443

Query: 486 RVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAG 545
            V D NDNAP F +P Y V V+ENNPPG ++ TV+ARD D   N  V+Y L+E  VG   
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER- 502

Query: 546 GAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDH 605
            ++S+Y+SV   +G +YAL+  D+E L  L  ++ A D G P L S+  +QV VLD+ND+
Sbjct: 503 -SLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDN 561

Query: 606 APVLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQ--QQEPREA 661
           AP L+ P      G+    VP       VVA+V+A DAD G N  L++ELQ     PR  
Sbjct: 562 APALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIP 621

Query: 662 FAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAP 721
           F +G  TGEI  T  L +    R  R L+++ D G P LT TATV  V     G+ P A 
Sbjct: 622 FRVGLYTGEISTTRVLDEADSPR-HRLLVLVKDHGEPALTATATV-LVSLVESGQAPKA- 678

Query: 722 ASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEV 781
                   SR     LG   +++  +  LI I + A S  L+L  ++  A  C+    E 
Sbjct: 679 -------SSRQSAGVLGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSALPTE- 729

Query: 782 RKGGALREERP-----GAAGGGASAPGSPEEAARGAGP 814
              G  R  +P      A G  + +   P+    G GP
Sbjct: 730 ---GGCRAGKPTLVCSSAVGSWSYSQQQPQRVCSGEGP 764


>gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score =  438 bits (1126), Expect = e-122
 Identities = 292/818 (35%), Positives = 426/818 (52%), Gaps = 74/818 (9%)

Query: 8   GSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRL 65
           GS  L  L L    W +   Q   + YS  EE   GT +G +A+DL ++++      FR+
Sbjct: 10  GSWRLLLLLLLLAAWKVGSGQ---LHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRV 66

Query: 66  MKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEV 125
             + +  LL V   +G L V ++ +DRE LCG++ +C +  +V+       ++ HV+VEV
Sbjct: 67  ASKRHRDLLEVSLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVFHVDVEV 123

Query: 126 RDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVEL 185
           +DVND+ P F      + VSE     +R PLE   D DVGAN + T RL+  H  F +++
Sbjct: 124 KDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSS-HDYFMLDV 182

Query: 186 QTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAF 245
            ++ D  +  +LVL + LDRE   A+ L L A DGG+P  + T  L V VLD ND++P F
Sbjct: 183 NSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTF 242

Query: 246 PQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGR 305
            Q    EV + E+A  G+ ++ L+A+DPDEG NG + ++F +         F +D  +G 
Sbjct: 243 EQSEY-EVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGE 301

Query: 306 LTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAP 365
           + + G +D+E+++ Y++ + A D+G  P A  C V+VRI D NDN P+IA+T L+ P   
Sbjct: 302 IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLP--- 358

Query: 366 ATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANG 425
                                              V E A   +++AL+S +D DSGANG
Sbjct: 359 -----------------------------------VREDAQFGTVIALISVNDLDSGANG 383

Query: 426 QVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTV 485
           QV C+L  H  F+L   +   Y +V  ++LDRER++ Y L + A D G+P L      +V
Sbjct: 384 QVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSV 443

Query: 486 RVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAG 545
            V D NDNAP F +P Y V V+ENNPPG ++ TV+ARD D   N  V+Y L+E  VG   
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER- 502

Query: 546 GAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDH 605
            ++S+Y+SV   +G +YAL+  D+E L  L  ++ A D G P L S+  +QV VLD+ND+
Sbjct: 503 -SLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDN 561

Query: 606 APVLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQ--QQEPREA 661
           AP L+ P      G+    VP       VVA+V+A DAD G N  L++ELQ     PR  
Sbjct: 562 APALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIP 621

Query: 662 FAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAP 721
           F +G  TGEI  T  L +    R  R L+++ D G P LT TATV  V     G+ P A 
Sbjct: 622 FRVGLYTGEISTTRVLDEADSPR-HRLLVLVKDHGEPALTATATV-LVSLVESGQAPKA- 678

Query: 722 ASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEV 781
                   SR     LG   +++  +  LI I + A S  L+L  ++  A  C+    E 
Sbjct: 679 -------SSRQSAGVLGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSALPTE- 729

Query: 782 RKGGALREERP-----GAAGGGASAPGSPEEAARGAGP 814
              G  R  +P      A G  + +   P+    G GP
Sbjct: 730 ---GGCRAGKPTLVCSSAVGSWSYSQQQPQRVCSGEGP 764


>gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo
           sapiens]
          Length = 824

 Score =  426 bits (1095), Expect = e-119
 Identities = 273/785 (34%), Positives = 412/785 (52%), Gaps = 83/785 (10%)

Query: 29  SKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSLLRVREGDGQLTVG 86
           S  +RYS  EE   GT +G +A+DL +++       FR+  + +  LL V   +G L V 
Sbjct: 28  SGQLRYSVPEEAKHGTFVGRIAQDLGLELEELVPRLFRVASKRHGDLLEVNLQNGILFV- 86

Query: 87  DAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSE 146
           ++ +DRE LCG++ +C +  +V+       ++ HVEVEV+D+ND+ P FP     +   E
Sbjct: 87  NSRIDREELCGRSAECSIHVEVIV--DRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPE 144

Query: 147 GAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRE 206
              + +R PLE   D D+G N L + +L+     F +++Q   + ++   LVL + LDRE
Sbjct: 145 SRLLDSRFPLEGASDADIGVNALLSYKLSSSEF-FFLDIQANDELSESLSLVLGKSLDRE 203

Query: 207 SQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLL 266
             A  +L LVA DGG+P  + T  + ++VLD ND+ P F Q +V +V+L E+   G+L++
Sbjct: 204 ETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQ-SVYKVKLLENTANGTLVV 262

Query: 267 DLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRA 326
            L+A+D DEGPN ++V++ G+      +  F +DP SG +   G +DYE   +YE+ V A
Sbjct: 263 KLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTA 322

Query: 327 QDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASS 386
            D+G    +  CK+ +++ D+NDN P+++IT L+ P                        
Sbjct: 323 TDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLP------------------------ 358

Query: 387 PAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGS 446
                         + E A+  +++AL++ SDRDSG NG V C+L  H  F+L   +   
Sbjct: 359 --------------ISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNY 404

Query: 447 YLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSV 506
           Y +V  ++LDRE ++ Y L + A D G+P L      ++ V D NDNAP F +P Y V V
Sbjct: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFV 464

Query: 507 RENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRS 566
           +ENNPPG ++ TV+A D D   N  V+Y L+E  VG    A+S+YVSV   +G +YAL+ 
Sbjct: 465 KENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGER--ALSSYVSVHAESGKVYALQP 522

Query: 567 FDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP--APANGSLEVAVP 624
            D+E +  L  ++ A D G P L S+  +QV VLD+ND+AP L+ P    A G++   VP
Sbjct: 523 LDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVP 582

Query: 625 GRTAKDTVVARVQARDADEGANGELAFELQ--QQEPREAFAIGRRTGEILLTGDLSQEPP 682
                  VVA+V+A DAD G N  L++ELQ      R  F +G  TGEI  T  L +   
Sbjct: 583 WSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVGLYTGEISTTRALDEADS 642

Query: 683 GRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGS 742
            R  R L+++ D G P LT TATV  V     G+ P A + A            +G +GS
Sbjct: 643 PR-HRLLVLVKDHGEPALTATATV-LVSLVESGQAPKASSRAW-----------VGAAGS 689

Query: 743 --VLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGAS 800
              L      ++I + A S  L+L  ++  A  C+    E                 GA 
Sbjct: 690 EATLVDVNVYLIIAICAVSSLLVLTVLLYTALRCSVPPTE-----------------GAR 732

Query: 801 APGSP 805
           APG P
Sbjct: 733 APGKP 737


>gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens]
          Length = 948

 Score =  426 bits (1095), Expect = e-119
 Identities = 273/785 (34%), Positives = 412/785 (52%), Gaps = 83/785 (10%)

Query: 29  SKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSLLRVREGDGQLTVG 86
           S  +RYS  EE   GT +G +A+DL +++       FR+  + +  LL V   +G L V 
Sbjct: 28  SGQLRYSVPEEAKHGTFVGRIAQDLGLELEELVPRLFRVASKRHGDLLEVNLQNGILFV- 86

Query: 87  DAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSE 146
           ++ +DRE LCG++ +C +  +V+       ++ HVEVEV+D+ND+ P FP     +   E
Sbjct: 87  NSRIDREELCGRSAECSIHVEVIV--DRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPE 144

Query: 147 GAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRE 206
              + +R PLE   D D+G N L + +L+     F +++Q   + ++   LVL + LDRE
Sbjct: 145 SRLLDSRFPLEGASDADIGVNALLSYKLSSSEF-FFLDIQANDELSESLSLVLGKSLDRE 203

Query: 207 SQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLL 266
             A  +L LVA DGG+P  + T  + ++VLD ND+ P F Q +V +V+L E+   G+L++
Sbjct: 204 ETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQ-SVYKVKLLENTANGTLVV 262

Query: 267 DLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRA 326
            L+A+D DEGPN ++V++ G+      +  F +DP SG +   G +DYE   +YE+ V A
Sbjct: 263 KLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTA 322

Query: 327 QDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASS 386
            D+G    +  CK+ +++ D+NDN P+++IT L+ P                        
Sbjct: 323 TDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLP------------------------ 358

Query: 387 PAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGS 446
                         + E A+  +++AL++ SDRDSG NG V C+L  H  F+L   +   
Sbjct: 359 --------------ISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNY 404

Query: 447 YLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSV 506
           Y +V  ++LDRE ++ Y L + A D G+P L      ++ V D NDNAP F +P Y V V
Sbjct: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFV 464

Query: 507 RENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRS 566
           +ENNPPG ++ TV+A D D   N  V+Y L+E  VG    A+S+YVSV   +G +YAL+ 
Sbjct: 465 KENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGER--ALSSYVSVHAESGKVYALQP 522

Query: 567 FDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP--APANGSLEVAVP 624
            D+E +  L  ++ A D G P L S+  +QV VLD+ND+AP L+ P    A G++   VP
Sbjct: 523 LDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVP 582

Query: 625 GRTAKDTVVARVQARDADEGANGELAFELQ--QQEPREAFAIGRRTGEILLTGDLSQEPP 682
                  VVA+V+A DAD G N  L++ELQ      R  F +G  TGEI  T  L +   
Sbjct: 583 WSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVGLYTGEISTTRALDEADS 642

Query: 683 GRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGS 742
            R  R L+++ D G P LT TATV  V     G+ P A + A            +G +GS
Sbjct: 643 PR-HRLLVLVKDHGEPALTATATV-LVSLVESGQAPKASSRAW-----------VGAAGS 689

Query: 743 --VLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGAS 800
              L      ++I + A S  L+L  ++  A  C+    E                 GA 
Sbjct: 690 EATLVDVNVYLIIAICAVSSLLVLTVLLYTALRCSVPPTE-----------------GAR 732

Query: 801 APGSP 805
           APG P
Sbjct: 733 APGKP 737


>gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens]
          Length = 936

 Score =  426 bits (1094), Expect = e-119
 Identities = 273/770 (35%), Positives = 410/770 (53%), Gaps = 65/770 (8%)

Query: 20  LCWVLSV---AQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSLL 74
           L W+L     A S  + YS  EE   GT +G +A+DL ++++      FR+  +    LL
Sbjct: 15  LLWLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGDLL 74

Query: 75  RVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPR 134
            V   +G L V ++ +DRE LC +  +C +  +V+       ++ HVEV V+D+ND+ PR
Sbjct: 75  EVNLQNGILFV-NSRIDREELCRRRAECSIHLEVIV--DRPLQVFHVEVAVKDINDNPPR 131

Query: 135 FPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQC 194
           F R +  + + E     +R PLE   D D+GAN     RL  P+  F ++++T  +    
Sbjct: 132 FSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRL-NPNEYFDLDVKTNEEETNF 190

Query: 195 ADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVE 254
            +LVL + LDRE    + L ++A DGG+P  + T  L + VLDAND++P F + ++  V 
Sbjct: 191 LELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDK-SIYNVR 249

Query: 255 LAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDY 314
           L E+AP G+L++ L+A+D DEG N ++V+ F      + +  F ++  +G + + G +DY
Sbjct: 250 LLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDY 309

Query: 315 ERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAA 374
           E  ++YE+++ A D+   P +  CKV+V++ DVNDN P++AIT L  P            
Sbjct: 310 EDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLP------------ 357

Query: 375 AAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGH 434
                                     V E A   +++AL+S SDRDSGANGQV C+L  H
Sbjct: 358 --------------------------VKEDAPLSTVIALISVSDRDSGANGQVTCSLMPH 391

Query: 435 EHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNA 494
             F+L   +   Y +V  ++LDRE ++ Y L + A D G+P L      +V V D NDNA
Sbjct: 392 VPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNA 451

Query: 495 PLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSV 554
           P F +P Y V V+ENNPPG ++ TV+ARD D   N  V+Y L+E  VG     +S+YVSV
Sbjct: 452 PAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER--PLSSYVSV 509

Query: 555 DPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP-- 612
              +G +YAL+  D+E +  L  ++ A D G P L S+  +QV VLD+ND+AP L+ P  
Sbjct: 510 HAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRV 569

Query: 613 APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQ--EPREAFAIGRRTGE 670
               G++   VP       VVA+V+A D D G N  L++ELQ      R  F +G  TGE
Sbjct: 570 GGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRVGLYTGE 629

Query: 671 ILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERS 730
           I  T  L +    R  R L+++ D G PPLT TATV  V     G+ P A         S
Sbjct: 630 ISTTRSLDETEAPR-HRLLVLVKDHGEPPLTATATV-LVSLVESGQAPKA--------SS 679

Query: 731 RPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
           R     +G   +++  +  LI I + A S  L+L  ++  A  C+ +  E
Sbjct: 680 RASAGAVGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSAQPTE 728


>gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo
           sapiens]
          Length = 816

 Score =  426 bits (1094), Expect = e-119
 Identities = 273/770 (35%), Positives = 410/770 (53%), Gaps = 65/770 (8%)

Query: 20  LCWVLSV---AQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSLL 74
           L W+L     A S  + YS  EE   GT +G +A+DL ++++      FR+  +    LL
Sbjct: 15  LLWLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGDLL 74

Query: 75  RVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPR 134
            V   +G L V ++ +DRE LC +  +C +  +V+       ++ HVEV V+D+ND+ PR
Sbjct: 75  EVNLQNGILFV-NSRIDREELCRRRAECSIHLEVIV--DRPLQVFHVEVAVKDINDNPPR 131

Query: 135 FPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQC 194
           F R +  + + E     +R PLE   D D+GAN     RL  P+  F ++++T  +    
Sbjct: 132 FSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRL-NPNEYFDLDVKTNEEETNF 190

Query: 195 ADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVE 254
            +LVL + LDRE    + L ++A DGG+P  + T  L + VLDAND++P F + ++  V 
Sbjct: 191 LELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDK-SIYNVR 249

Query: 255 LAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDY 314
           L E+AP G+L++ L+A+D DEG N ++V+ F      + +  F ++  +G + + G +DY
Sbjct: 250 LLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDY 309

Query: 315 ERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAA 374
           E  ++YE+++ A D+   P +  CKV+V++ DVNDN P++AIT L  P            
Sbjct: 310 EDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLP------------ 357

Query: 375 AAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGH 434
                                     V E A   +++AL+S SDRDSGANGQV C+L  H
Sbjct: 358 --------------------------VKEDAPLSTVIALISVSDRDSGANGQVTCSLMPH 391

Query: 435 EHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNA 494
             F+L   +   Y +V  ++LDRE ++ Y L + A D G+P L      +V V D NDNA
Sbjct: 392 VPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNA 451

Query: 495 PLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSV 554
           P F +P Y V V+ENNPPG ++ TV+ARD D   N  V+Y L+E  VG     +S+YVSV
Sbjct: 452 PAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER--PLSSYVSV 509

Query: 555 DPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP-- 612
              +G +YAL+  D+E +  L  ++ A D G P L S+  +QV VLD+ND+AP L+ P  
Sbjct: 510 HAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRV 569

Query: 613 APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQ--EPREAFAIGRRTGE 670
               G++   VP       VVA+V+A D D G N  L++ELQ      R  F +G  TGE
Sbjct: 570 GGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRVGLYTGE 629

Query: 671 ILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERS 730
           I  T  L +    R  R L+++ D G PPLT TATV  V     G+ P A         S
Sbjct: 630 ISTTRSLDETEAPR-HRLLVLVKDHGEPPLTATATV-LVSLVESGQAPKA--------SS 679

Query: 731 RPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
           R     +G   +++  +  LI I + A S  L+L  ++  A  C+ +  E
Sbjct: 680 RASAGAVGPEAALVDVNVYLI-IAICAVSSLLVLTLLLYTALRCSAQPTE 728


>gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo
           sapiens]
          Length = 803

 Score =  424 bits (1091), Expect = e-118
 Identities = 287/834 (34%), Positives = 431/834 (51%), Gaps = 76/834 (9%)

Query: 2   SPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG-- 59
           +P  R G  CL    L    W +   Q   + YS  EE   GT +G +A+DL ++++   
Sbjct: 4   TPEDRLGKQCLLLPLLLLAAWKVGSGQ---LHYSVPEEAKHGTFVGRIAQDLGLELAELV 60

Query: 60  DTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLV 119
              FR+  +    LL V   +G L V ++ +DRE LCG++ +C +  +V+       ++ 
Sbjct: 61  PRLFRMASKDREDLLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVF 117

Query: 120 HVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHS 179
           HV+VEVRD+ND+ P FP  +  V + E     +  PLE   D DVG+N + T +L+    
Sbjct: 118 HVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEY 177

Query: 180 PFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAN 239
            F ++++  +D  +   L+L + LDRE   A++L L A DGG+P  + T  L V VLD N
Sbjct: 178 -FGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVN 236

Query: 240 DHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRL 299
           D++P F Q    EV + E+A  G+ ++ L+A+D DEG NG + ++F +         F +
Sbjct: 237 DNAPTFEQSEY-EVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSI 295

Query: 300 DPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPL 359
           D  +G + + G +D+E+++ Y++ + A D+G  P A  C V+VRI D NDN P+IA+T L
Sbjct: 296 DRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSL 355

Query: 360 AAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDR 419
           + P                                      V E A   +++AL+S +D 
Sbjct: 356 SLP--------------------------------------VREDAQFGTVIALISVNDL 377

Query: 420 DSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRT 479
           DSGANGQV C+L  H  F+L   +   Y +V  ++LDRE ++ Y L + A D G+P L  
Sbjct: 378 DSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWA 437

Query: 480 VRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEA 539
               +V V D NDNAP F +P Y V V+ENNPPG ++ TV+ARD D   N  V+Y L+E 
Sbjct: 438 TASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVER 497

Query: 540 EVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRV 599
            VG    A+S+Y+SV   +G +YAL+  D+E L  L  ++ A D G P L S+  +QV V
Sbjct: 498 RVGER--ALSSYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFV 555

Query: 600 LDQNDHAPVLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQ--Q 655
           LD+ND+AP L+ P      G++   VP       VVA+V+A DAD G N  L++ELQ   
Sbjct: 556 LDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPA 615

Query: 656 QEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGG 715
              R  F +G  TGEI  T  L +    R  R L+++ D G P LT TATV  V     G
Sbjct: 616 SSARFPFRVGLYTGEISTTRVLDEADSPR-HRLLVLVKDHGEPALTATATV-LVSLVESG 673

Query: 716 RGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
           + P A +S  S   + P  + + V+          ++I + A S  L+L  ++  A  C+
Sbjct: 674 QAPKA-SSRASVGAAGPEAALVDVN--------VYLIIAICAVSSLLVLTLLLYTALRCS 724

Query: 776 RRKKEVRKGGALREERP-----GAAGGGASAPGSPEEAARGAGPRPNMFDVLTF 824
               E    GA   ++P      A G  + +    +    G GP P M D++ F
Sbjct: 725 APPTE----GACTADKPTLVCSSAVGSWSYSQQRRQRVCSGEGP-PKM-DLMAF 772


>gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score =  424 bits (1091), Expect = e-118
 Identities = 287/834 (34%), Positives = 431/834 (51%), Gaps = 76/834 (9%)

Query: 2   SPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG-- 59
           +P  R G  CL    L    W +   Q   + YS  EE   GT +G +A+DL ++++   
Sbjct: 4   TPEDRLGKQCLLLPLLLLAAWKVGSGQ---LHYSVPEEAKHGTFVGRIAQDLGLELAELV 60

Query: 60  DTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLV 119
              FR+  +    LL V   +G L V ++ +DRE LCG++ +C +  +V+       ++ 
Sbjct: 61  PRLFRMASKDREDLLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--DRPLQVF 117

Query: 120 HVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHS 179
           HV+VEVRD+ND+ P FP  +  V + E     +  PLE   D DVG+N + T +L+    
Sbjct: 118 HVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEY 177

Query: 180 PFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAN 239
            F ++++  +D  +   L+L + LDRE   A++L L A DGG+P  + T  L V VLD N
Sbjct: 178 -FGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVN 236

Query: 240 DHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRL 299
           D++P F Q    EV + E+A  G+ ++ L+A+D DEG NG + ++F +         F +
Sbjct: 237 DNAPTFEQSEY-EVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSI 295

Query: 300 DPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPL 359
           D  +G + + G +D+E+++ Y++ + A D+G  P A  C V+VRI D NDN P+IA+T L
Sbjct: 296 DRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSL 355

Query: 360 AAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDR 419
           + P                                      V E A   +++AL+S +D 
Sbjct: 356 SLP--------------------------------------VREDAQFGTVIALISVNDL 377

Query: 420 DSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRT 479
           DSGANGQV C+L  H  F+L   +   Y +V  ++LDRE ++ Y L + A D G+P L  
Sbjct: 378 DSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWA 437

Query: 480 VRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEA 539
               +V V D NDNAP F +P Y V V+ENNPPG ++ TV+ARD D   N  V+Y L+E 
Sbjct: 438 TASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVER 497

Query: 540 EVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRV 599
            VG    A+S+Y+SV   +G +YAL+  D+E L  L  ++ A D G P L S+  +QV V
Sbjct: 498 RVGER--ALSSYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFV 555

Query: 600 LDQNDHAPVLVHP--APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQ--Q 655
           LD+ND+AP L+ P      G++   VP       VVA+V+A DAD G N  L++ELQ   
Sbjct: 556 LDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPA 615

Query: 656 QEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGG 715
              R  F +G  TGEI  T  L +    R  R L+++ D G P LT TATV  V     G
Sbjct: 616 SSARFPFRVGLYTGEISTTRVLDEADSPR-HRLLVLVKDHGEPALTATATV-LVSLVESG 673

Query: 716 RGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
           + P A +S  S   + P  + + V+          ++I + A S  L+L  ++  A  C+
Sbjct: 674 QAPKA-SSRASVGAAGPEAALVDVN--------VYLIIAICAVSSLLVLTLLLYTALRCS 724

Query: 776 RRKKEVRKGGALREERP-----GAAGGGASAPGSPEEAARGAGPRPNMFDVLTF 824
               E    GA   ++P      A G  + +    +    G GP P M D++ F
Sbjct: 725 APPTE----GACTADKPTLVCSSAVGSWSYSQQRRQRVCSGEGP-PKM-DLMAF 772


>gi|14165400 protocadherin alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 807

 Score =  422 bits (1085), Expect = e-118
 Identities = 275/768 (35%), Positives = 409/768 (53%), Gaps = 70/768 (9%)

Query: 20  LCWVLSVAQ----SKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSL 73
           L W+L +A     S  + YS  EE   GT +G +A+DL ++++      FR+  + +  L
Sbjct: 15  LLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDL 74

Query: 74  LRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAP 133
           L V   +G L V ++ +DRE LC  + +C +  ++++      ++ HVEV+V+D+ND+ P
Sbjct: 75  LEVNLQNGILFV-NSRIDREELCQWSAECSIHLELIA--DRPLQVFHVEVKVKDINDNPP 131

Query: 134 RFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQ 193
            F   +  + + E   + +R P+E   D D+GAN L T  L+ P   F ++++   + ++
Sbjct: 132 VFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLS-PSDYFSLDVEASDELSK 190

Query: 194 CADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEV 253
              L L + LDRE      L L A DGG+P    T  L + VLD ND++P F Q AV  V
Sbjct: 191 SLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQ-AVYRV 249

Query: 254 ELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVD 313
            L E    G+L+  L+A+D DEG NG+VVF+F +    + +  F++D  SG + L   +D
Sbjct: 250 HLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLD 309

Query: 314 YERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAA 373
           YE   +YE+ V+A D+G  P +  CKV+V++ DVNDNAP++A+T L  P           
Sbjct: 310 YEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLP----------- 358

Query: 374 AAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYG 433
                                      + E A   +++AL++ SDRDSGANGQV C+L  
Sbjct: 359 ---------------------------IREDAPLSTVIALITVSDRDSGANGQVTCSLMP 391

Query: 434 HEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDN 493
           H  F+L   +   Y +V  ++LDRE ++ Y L + A D G+P L      +V V D NDN
Sbjct: 392 HVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDN 451

Query: 494 APLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVS 553
           AP F +P Y V V+ENNPPG ++ TV+ARD D   N  V+Y L+E  VG    A+S YVS
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER--ALSNYVS 509

Query: 554 VDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPA 613
           V   +G +YAL+  D+E L  L  ++ A D G P L S+  +QV VLD+ND+AP L+ P 
Sbjct: 510 VHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPR 569

Query: 614 PAN--GSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREAFAIGRRTG 669
                G++   VP       VVA+V+A DAD G N  L++ELQ      R  F +G  TG
Sbjct: 570 VGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFRVGLYTG 629

Query: 670 EILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPER 729
           EI  T  L +    R +R L+++ D G P LT TATV  V     G+ P A + A     
Sbjct: 630 EISTTRVLDEADLSR-YRLLVLVKDHGEPALTATATV-LVSLVESGQAPKASSRAS---- 683

Query: 730 SRPPGSRLGVSG--SVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
                  +GV+G  + L      ++I + A S  L+L  ++  A  C+
Sbjct: 684 -------VGVAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCS 724


>gi|9256582 protocadherin alpha 1 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score =  422 bits (1085), Expect = e-118
 Identities = 275/768 (35%), Positives = 409/768 (53%), Gaps = 70/768 (9%)

Query: 20  LCWVLSVAQ----SKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSSL 73
           L W+L +A     S  + YS  EE   GT +G +A+DL ++++      FR+  + +  L
Sbjct: 15  LLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDL 74

Query: 74  LRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAP 133
           L V   +G L V ++ +DRE LC  + +C +  ++++      ++ HVEV+V+D+ND+ P
Sbjct: 75  LEVNLQNGILFV-NSRIDREELCQWSAECSIHLELIA--DRPLQVFHVEVKVKDINDNPP 131

Query: 134 RFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQ 193
            F   +  + + E   + +R P+E   D D+GAN L T  L+ P   F ++++   + ++
Sbjct: 132 VFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLS-PSDYFSLDVEASDELSK 190

Query: 194 CADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEV 253
              L L + LDRE      L L A DGG+P    T  L + VLD ND++P F Q AV  V
Sbjct: 191 SLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQ-AVYRV 249

Query: 254 ELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVD 313
            L E    G+L+  L+A+D DEG NG+VVF+F +    + +  F++D  SG + L   +D
Sbjct: 250 HLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLD 309

Query: 314 YERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAA 373
           YE   +YE+ V+A D+G  P +  CKV+V++ DVNDNAP++A+T L  P           
Sbjct: 310 YEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLP----------- 358

Query: 374 AAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYG 433
                                      + E A   +++AL++ SDRDSGANGQV C+L  
Sbjct: 359 ---------------------------IREDAPLSTVIALITVSDRDSGANGQVTCSLMP 391

Query: 434 HEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDN 493
           H  F+L   +   Y +V  ++LDRE ++ Y L + A D G+P L      +V V D NDN
Sbjct: 392 HVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDN 451

Query: 494 APLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVS 553
           AP F +P Y V V+ENNPPG ++ TV+ARD D   N  V+Y L+E  VG    A+S YVS
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGER--ALSNYVS 509

Query: 554 VDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPA 613
           V   +G +YAL+  D+E L  L  ++ A D G P L S+  +QV VLD+ND+AP L+ P 
Sbjct: 510 VHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPR 569

Query: 614 PAN--GSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREAFAIGRRTG 669
                G++   VP       VVA+V+A DAD G N  L++ELQ      R  F +G  TG
Sbjct: 570 VGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFRVGLYTG 629

Query: 670 EILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPER 729
           EI  T  L +    R +R L+++ D G P LT TATV  V     G+ P A + A     
Sbjct: 630 EISTTRVLDEADLSR-YRLLVLVKDHGEPALTATATV-LVSLVESGQAPKASSRAS---- 683

Query: 730 SRPPGSRLGVSG--SVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCN 775
                  +GV+G  + L      ++I + A S  L+L  ++  A  C+
Sbjct: 684 -------VGVAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCS 724


>gi|9256594 protocadherin alpha 7 isoform 1 precursor [Homo sapiens]
          Length = 937

 Score =  422 bits (1085), Expect = e-118
 Identities = 284/839 (33%), Positives = 430/839 (51%), Gaps = 79/839 (9%)

Query: 15  LQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRLMKQFNSS 72
           L LF +      A    + YS  EE   G  +G +A+DL ++++      FR + +F   
Sbjct: 14  LLLFIIILAAWEAGRGQLHYSVPEEAKHGNFVGRIAQDLGLELAELVPRLFRAVCKFRGD 73

Query: 73  LLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHA 132
           LL V   +G L V ++ +DRE LCG++ +C +  +V+   +   ++ HV+VEV+D+ND+ 
Sbjct: 74  LLEVNLQNGILFV-NSRIDREELCGRSAECSIHLEVIV--ERPLQVFHVDVEVKDINDNP 130

Query: 133 PRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGA 192
           P FP  Q  + ++E   + +R PLE   D D+G N L T RL+ P+  F +++ T     
Sbjct: 131 PVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLS-PNEYFFLDVPTSNQQV 189

Query: 193 QCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAE 252
           +   LVL + LDRE      L L A DGG+P  + T  L + VLD ND++P F +  +  
Sbjct: 190 KPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDR-TLYT 248

Query: 253 VELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPV 312
           V+L E+  +G+L++  +A+D DEG NGD++++F +   P+ +  F +DP SG +T+ G +
Sbjct: 249 VKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHM 308

Query: 313 DYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAA 372
           D+E    +++ V A D+G  P A  C V+V + DVNDNAP + +T L+ P          
Sbjct: 309 DFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLP---------- 358

Query: 373 AAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALY 432
                                       +PE A   +++ L+S  DRD G NGQV C+L 
Sbjct: 359 ----------------------------IPEDAQPGTVITLISVFDRDFGVNGQVTCSLT 390

Query: 433 GHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDEND 492
               F+L   +   Y +V  ++LDRE ++ Y L + A D G+P L      +V V D ND
Sbjct: 391 PRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450

Query: 493 NAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYV 552
           NAP F +P Y V V+ENNPPG ++ TV+A D D  +N  V+Y L+E  VG    A+S+YV
Sbjct: 451 NAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGER--ALSSYV 508

Query: 553 SVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHP 612
           SV   +G +YAL+  D+E L  L  ++ A D G P L S+  +QV VLD+ND+AP L+ P
Sbjct: 509 SVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAP 568

Query: 613 --APANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREA--FAIGRRT 668
                 G++   VP       VVA+V+A DAD G N  L++ELQ      +  F +G  T
Sbjct: 569 RVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFRVGLYT 628

Query: 669 GEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPE 728
           GEI  T  L +    R  R L+++ D G P LT TATV  V     G+ P A + A    
Sbjct: 629 GEISTTRALDETDAPR-HRLLVLVKDHGEPSLTATATV-LVSLVESGQAPKASSRAS--- 683

Query: 729 RSRPPGSRLGVSG--SVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGA 786
                   LG++G  + L      ++I + A S  L+L  ++  A  C+    E    GA
Sbjct: 684 --------LGIAGPETELVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPSSE----GA 731

Query: 787 LREERP-----GAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAP 840
               +P      A G  + +    +    G GP     D++ F  +   P G  + D P
Sbjct: 732 CSLVKPTLVCSSAVGSWSFSQQRRQRVCSGEGPPKT--DLMAF--SPSLPQGPSSTDNP 786


>gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  421 bits (1083), Expect = e-117
 Identities = 272/778 (34%), Positives = 415/778 (53%), Gaps = 79/778 (10%)

Query: 32  VRYSTFEEDAPGTVIGTLAEDLHMKVS--GDTSFRLMKQFNSSLLRVREGDGQLTVGDAG 89
           +RYS  EE   G+ +G ++ DL ++     +   R++ +  + L  +    G L      
Sbjct: 31  IRYSVPEELEKGSRVGDISRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGR- 89

Query: 90  LDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAA 149
           +DRE LC  A +C L  D++   +++ ++  VEVEVRD+ND+AP F  +++ +++SE AA
Sbjct: 90  IDREELCMGAIKCQLNLDILM--EDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAA 147

Query: 150 VGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQA 209
              R PL    D D+G N LQ+  L+ P++ F + +Q  ADG++  +LVL + LDRE +A
Sbjct: 148 TEMRFPLPHAWDPDIGKNSLQSYELS-PNTHFSLIVQNGADGSKYPELVLKRALDREEKA 206

Query: 210 AYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLD 269
           A+ L L A DGG P R+ TA + V VLDAND++PAF Q       + E+  +G+ LL ++
Sbjct: 207 AHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEY-RASVPENLALGTQLLVVN 265

Query: 270 AADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDR 329
           A DPDEG N +V ++F      +A ++F+LD  SG ++  G +D+E    Y+++V+A D 
Sbjct: 266 ATDPDEGVNAEVRYSF-RYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDN 324

Query: 330 GPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAG 389
                +A  KV++ + DVNDNAP++ +T LA                             
Sbjct: 325 AG--YSARAKVLITVLDVNDNAPEVVLTSLA----------------------------- 353

Query: 390 AGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLV 449
                    S VPE + R +L+AL++ +D+DS  NGQV C + G+  F+L+ +Y   Y +
Sbjct: 354 ---------SSVPENSPRGTLIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSL 404

Query: 450 VTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVREN 509
           VT   LDRE++  YN+T+ A DRG PPL T    ++ V D NDN P+F +  Y   + EN
Sbjct: 405 VTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPEN 464

Query: 510 NPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDY 569
           NP G  L +V A D D   N Q+TY L E  +   G ++S+YVS++  TG +YAL SFDY
Sbjct: 465 NPRGVSLVSVTAHDPDCEENAQITYSLAENTI--QGASLSSYVSINSDTGVLYALSSFDY 522

Query: 570 ETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPA-PANGSLEVAVPGRTA 628
           E  R L V++ A D G P LSS+  + + VLDQND+AP +++PA P +GS  V +  R+A
Sbjct: 523 EQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSA 582

Query: 629 K-DTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEI-----LLTGDLSQEPP 682
           +   +V +V A D D G N  L++ L +      F++G  TGE+     LL  D  ++  
Sbjct: 583 EPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQ-- 640

Query: 683 GRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGS 742
                 ++ + D G+PPL+ T T++  V     +  A   S  SP  S      L     
Sbjct: 641 ----SLVVAVQDHGQPPLSATVTLTVAVADSIPQVLADLGSLESPANSETSDLTL----- 691

Query: 743 VLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGAS 800
                   +V+ V A SC  L   I+ +A     R +   K   L+    G  G  AS
Sbjct: 692 -------YLVVAVAAVSCVFLAFVILLLAL----RLRRWHKSRLLQASGGGLTGAPAS 738



 Score = 90.5 bits (223), Expect = 8e-18
 Identities = 95/317 (29%), Positives = 135/317 (42%), Gaps = 55/317 (17%)

Query: 394 EAGATSL---VPEGAARESLVALVSTSDRDSG------ANGQVRCALYGHEH-FRLQPAY 443
           E G T +   VPE   + S V  +S   RD G      A   VR    G    F L P  
Sbjct: 25  ETGCTQIRYSVPEELEKGSRVGDIS---RDLGLEPRELAERGVRIIPRGRTQLFALNPR- 80

Query: 444 AGSYLVVTAASLDRERIA------EYNLTLVAEDRGAPPLRTVRPY--TVRVGDENDNAP 495
           +GS  +VTA  +DRE +       + NL ++ ED+       V+ Y   V V D NDNAP
Sbjct: 81  SGS--LVTAGRIDREELCMGAIKCQLNLDILMEDK-------VKIYGVEVEVRDINDNAP 131

Query: 496 LFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVD 555
            F     E+ + EN           A D D+G+N   +Y L          + +T+ S+ 
Sbjct: 132 YFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYEL----------SPNTHFSLI 181

Query: 556 PATGA-------IYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPV 608
              GA       +   R+ D E      + + ASDGG P  + +A ++V VLD ND+AP 
Sbjct: 182 VQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPA 241

Query: 609 LVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREA--FAIGR 666
              P         +VP   A  T +  V A D DEG N E+ +  +  + + A  F +  
Sbjct: 242 FAQP-----EYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDC 296

Query: 667 RTGEILLTGDLSQEPPG 683
            +G I   G+L  E  G
Sbjct: 297 NSGTISTIGELDHEESG 313


>gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  421 bits (1083), Expect = e-117
 Identities = 272/778 (34%), Positives = 415/778 (53%), Gaps = 79/778 (10%)

Query: 32  VRYSTFEEDAPGTVIGTLAEDLHMKVS--GDTSFRLMKQFNSSLLRVREGDGQLTVGDAG 89
           +RYS  EE   G+ +G ++ DL ++     +   R++ +  + L  +    G L      
Sbjct: 31  IRYSVPEELEKGSRVGDISRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGR- 89

Query: 90  LDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAA 149
           +DRE LC  A +C L  D++   +++ ++  VEVEVRD+ND+AP F  +++ +++SE AA
Sbjct: 90  IDREELCMGAIKCQLNLDILM--EDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAA 147

Query: 150 VGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQA 209
              R PL    D D+G N LQ+  L+ P++ F + +Q  ADG++  +LVL + LDRE +A
Sbjct: 148 TEMRFPLPHAWDPDIGKNSLQSYELS-PNTHFSLIVQNGADGSKYPELVLKRALDREEKA 206

Query: 210 AYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLD 269
           A+ L L A DGG P R+ TA + V VLDAND++PAF Q       + E+  +G+ LL ++
Sbjct: 207 AHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEY-RASVPENLALGTQLLVVN 265

Query: 270 AADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDR 329
           A DPDEG N +V ++F      +A ++F+LD  SG ++  G +D+E    Y+++V+A D 
Sbjct: 266 ATDPDEGVNAEVRYSF-RYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDN 324

Query: 330 GPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAG 389
                +A  KV++ + DVNDNAP++ +T LA                             
Sbjct: 325 AG--YSARAKVLITVLDVNDNAPEVVLTSLA----------------------------- 353

Query: 390 AGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLV 449
                    S VPE + R +L+AL++ +D+DS  NGQV C + G+  F+L+ +Y   Y +
Sbjct: 354 ---------SSVPENSPRGTLIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSL 404

Query: 450 VTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVREN 509
           VT   LDRE++  YN+T+ A DRG PPL T    ++ V D NDN P+F +  Y   + EN
Sbjct: 405 VTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPEN 464

Query: 510 NPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDY 569
           NP G  L +V A D D   N Q+TY L E  +   G ++S+YVS++  TG +YAL SFDY
Sbjct: 465 NPRGVSLVSVTAHDPDCEENAQITYSLAENTI--QGASLSSYVSINSDTGVLYALSSFDY 522

Query: 570 ETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPA-PANGSLEVAVPGRTA 628
           E  R L V++ A D G P LSS+  + + VLDQND+AP +++PA P +GS  V +  R+A
Sbjct: 523 EQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSA 582

Query: 629 K-DTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEI-----LLTGDLSQEPP 682
           +   +V +V A D D G N  L++ L +      F++G  TGE+     LL  D  ++  
Sbjct: 583 EPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQ-- 640

Query: 683 GRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGS 742
                 ++ + D G+PPL+ T T++  V     +  A   S  SP  S      L     
Sbjct: 641 ----SLVVAVQDHGQPPLSATVTLTVAVADSIPQVLADLGSLESPANSETSDLTL----- 691

Query: 743 VLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGAS 800
                   +V+ V A SC  L   I+ +A     R +   K   L+    G  G  AS
Sbjct: 692 -------YLVVAVAAVSCVFLAFVILLLAL----RLRRWHKSRLLQASGGGLTGAPAS 738



 Score = 90.5 bits (223), Expect = 8e-18
 Identities = 95/317 (29%), Positives = 135/317 (42%), Gaps = 55/317 (17%)

Query: 394 EAGATSL---VPEGAARESLVALVSTSDRDSG------ANGQVRCALYGHEH-FRLQPAY 443
           E G T +   VPE   + S V  +S   RD G      A   VR    G    F L P  
Sbjct: 25  ETGCTQIRYSVPEELEKGSRVGDIS---RDLGLEPRELAERGVRIIPRGRTQLFALNPR- 80

Query: 444 AGSYLVVTAASLDRERIA------EYNLTLVAEDRGAPPLRTVRPY--TVRVGDENDNAP 495
           +GS  +VTA  +DRE +       + NL ++ ED+       V+ Y   V V D NDNAP
Sbjct: 81  SGS--LVTAGRIDREELCMGAIKCQLNLDILMEDK-------VKIYGVEVEVRDINDNAP 131

Query: 496 LFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVD 555
            F     E+ + EN           A D D+G+N   +Y L          + +T+ S+ 
Sbjct: 132 YFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYEL----------SPNTHFSLI 181

Query: 556 PATGA-------IYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPV 608
              GA       +   R+ D E      + + ASDGG P  + +A ++V VLD ND+AP 
Sbjct: 182 VQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPA 241

Query: 609 LVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREA--FAIGR 666
              P         +VP   A  T +  V A D DEG N E+ +  +  + + A  F +  
Sbjct: 242 FAQP-----EYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDC 296

Query: 667 RTGEILLTGDLSQEPPG 683
            +G I   G+L  E  G
Sbjct: 297 NSGTISTIGELDHEESG 313


>gi|14165381 protocadherin alpha 10 isoform 2 precursor [Homo
           sapiens]
          Length = 844

 Score =  421 bits (1083), Expect = e-117
 Identities = 275/780 (35%), Positives = 416/780 (53%), Gaps = 68/780 (8%)

Query: 8   GSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRL 65
           G  CL    L    W +   Q   + YS +EE   GT +G +A+DL ++++      FR+
Sbjct: 9   GVQCLLLSLLLLAAWEVGSGQ---LHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRV 65

Query: 66  MKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEV 125
             + +  LL V   +G L V ++ +DRE LCG++ +C +  +V+       ++ HV+VEV
Sbjct: 66  ASKRHGDLLEVNLQNGILFV-NSRIDREELCGRSVECSIHLEVIV--DRPLQVFHVDVEV 122

Query: 126 RDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVEL 185
           +D+ND+ PRF   +  + + E   + +R PLE   D DVG N L T +L+ P+  F +++
Sbjct: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLS-PNEYFVLDI 181

Query: 186 QTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAF 245
             + D  +   LVL + LDRE      L L A DGG+P  + + +L + VLDAND++P F
Sbjct: 182 INKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIF 241

Query: 246 PQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGR 305
            +  V EV++ E+    +L++ L+A+D DEG N +++++F +  PP  RR F ++ R+G 
Sbjct: 242 DR-PVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE 300

Query: 306 LTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAP 365
           + +   +D+E  +TYE+ V   D+G  P    C V+V + D NDN+P++ +T L+ P   
Sbjct: 301 IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLP--- 357

Query: 366 ATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANG 425
                                              V E A   +++AL+S SD DSGANG
Sbjct: 358 -----------------------------------VKEDAQVGTVIALISVSDHDSGANG 382

Query: 426 QVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTV 485
           QV C+L  H  F+L   Y   Y +V  ++LDRER++ Y L + A D G+PPL      +V
Sbjct: 383 QVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSV 442

Query: 486 RVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAG 545
            V D NDNAP F +  Y V V+ENNPPG ++ TV+A D D   N  V+Y L+E  +G   
Sbjct: 443 EVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGER- 501

Query: 546 GAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDH 605
            ++S+YVSV   +G +YAL+  D+E L  L  ++ A DGG P L S+  +QV VLD+ND+
Sbjct: 502 -SLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDN 560

Query: 606 AP-VLVHPA-PANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREA 661
           AP +L  PA  A G++   V        VVA+V+A DAD G N  L++ELQ      R  
Sbjct: 561 APALLASPAGSAGGAVSELVLRSVVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIP 620

Query: 662 FAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAP 721
           F +G  TGEI  T  L +    R  R L+++ D G P LT TATV  V    G + P A 
Sbjct: 621 FRVGLYTGEISTTRALDETDSPRQ-RLLVLVKDHGEPSLTATATV-LVSLVEGSQAPKAS 678

Query: 722 ASAGSPERSRPPGSRLGVSGSVLQWDTPL-IVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
           + A            +GV+  V   D  + ++I + A S  L+L  ++  A  C+    E
Sbjct: 679 SRAS-----------VGVAPEVALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAAPTE 727


>gi|9256574 protocadherin alpha 10 isoform 1 precursor [Homo
           sapiens]
          Length = 948

 Score =  421 bits (1083), Expect = e-117
 Identities = 275/780 (35%), Positives = 416/780 (53%), Gaps = 68/780 (8%)

Query: 8   GSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSG--DTSFRL 65
           G  CL    L    W +   Q   + YS +EE   GT +G +A+DL ++++      FR+
Sbjct: 9   GVQCLLLSLLLLAAWEVGSGQ---LHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRV 65

Query: 66  MKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEV 125
             + +  LL V   +G L V ++ +DRE LCG++ +C +  +V+       ++ HV+VEV
Sbjct: 66  ASKRHGDLLEVNLQNGILFV-NSRIDREELCGRSVECSIHLEVIV--DRPLQVFHVDVEV 122

Query: 126 RDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVEL 185
           +D+ND+ PRF   +  + + E   + +R PLE   D DVG N L T +L+ P+  F +++
Sbjct: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLS-PNEYFVLDI 181

Query: 186 QTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAF 245
             + D  +   LVL + LDRE      L L A DGG+P  + + +L + VLDAND++P F
Sbjct: 182 INKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIF 241

Query: 246 PQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGR 305
            +  V EV++ E+    +L++ L+A+D DEG N +++++F +  PP  RR F ++ R+G 
Sbjct: 242 DR-PVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE 300

Query: 306 LTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAP 365
           + +   +D+E  +TYE+ V   D+G  P    C V+V + D NDN+P++ +T L+ P   
Sbjct: 301 IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLP--- 357

Query: 366 ATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANG 425
                                              V E A   +++AL+S SD DSGANG
Sbjct: 358 -----------------------------------VKEDAQVGTVIALISVSDHDSGANG 382

Query: 426 QVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTV 485
           QV C+L  H  F+L   Y   Y +V  ++LDRER++ Y L + A D G+PPL      +V
Sbjct: 383 QVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSV 442

Query: 486 RVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAG 545
            V D NDNAP F +  Y V V+ENNPPG ++ TV+A D D   N  V+Y L+E  +G   
Sbjct: 443 EVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGER- 501

Query: 546 GAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDH 605
            ++S+YVSV   +G +YAL+  D+E L  L  ++ A DGG P L S+  +QV VLD+ND+
Sbjct: 502 -SLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDN 560

Query: 606 AP-VLVHPA-PANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQE--PREA 661
           AP +L  PA  A G++   V        VVA+V+A DAD G N  L++ELQ      R  
Sbjct: 561 APALLASPAGSAGGAVSELVLRSVVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIP 620

Query: 662 FAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAP 721
           F +G  TGEI  T  L +    R  R L+++ D G P LT TATV  V    G + P A 
Sbjct: 621 FRVGLYTGEISTTRALDETDSPRQ-RLLVLVKDHGEPSLTATATV-LVSLVEGSQAPKAS 678

Query: 722 ASAGSPERSRPPGSRLGVSGSVLQWDTPL-IVIIVLAGSCTLLLAAIIAIATTCNRRKKE 780
           + A            +GV+  V   D  + ++I + A S  L+L  ++  A  C+    E
Sbjct: 679 SRAS-----------VGVAPEVALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAAPTE 727


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,193,355
Number of Sequences: 37866
Number of extensions: 2647030
Number of successful extensions: 24277
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 227
Number of HSP's successfully gapped in prelim test: 383
Number of HSP's that attempted gapping in prelim test: 14337
Number of HSP's gapped (non-prelim): 4189
length of query: 1070
length of database: 18,247,518
effective HSP length: 113
effective length of query: 957
effective length of database: 13,968,660
effective search space: 13368007620
effective search space used: 13368007620
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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