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Search of human proteins with 65786661
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|65786661 BTB (POZ) domain containing 11 isoform a [Homo
sapiens]
(1104 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|65786661 BTB (POZ) domain containing 11 isoform a [Homo sapiens] 2232 0.0
gi|62953116 BTB (POZ) domain containing 11 isoform b [Homo sapiens] 1220 0.0
gi|21956639 ankyrin repeat and BTB (POZ) domain containing 2 [Ho... 974 0.0
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 72 3e-12
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 72 3e-12
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 72 3e-12
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 72 3e-12
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 70 8e-12
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 70 8e-12
gi|4557445 regulator of chromosome condensation and BTB domain c... 69 2e-11
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom... 68 5e-11
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 65 5e-10
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 63 2e-09
gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo sapi... 62 2e-09
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 62 4e-09
gi|67906195 ankyrin repeat and sterile alpha motif domain contai... 61 5e-09
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 61 5e-09
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 61 5e-09
gi|45643138 kelch-like 13 [Homo sapiens] 60 1e-08
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 60 1e-08
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 60 1e-08
gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isof... 60 1e-08
gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isof... 60 1e-08
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 59 3e-08
gi|28461129 ankyrin repeat and MYND domain containing 2 [Homo sa... 59 3e-08
gi|40807500 kelch-like 20 [Homo sapiens] 59 3e-08
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 59 3e-08
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 58 4e-08
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 58 4e-08
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 58 4e-08
>gi|65786661 BTB (POZ) domain containing 11 isoform a [Homo sapiens]
Length = 1104
Score = 2232 bits (5784), Expect = 0.0
Identities = 1104/1104 (100%), Positives = 1104/1104 (100%)
Query: 1 MARRGKKPVVRTLEDLTLDSGYGGAADSVRSSNLSLCCSDSHPASPYGGSCWPPLADSMH 60
MARRGKKPVVRTLEDLTLDSGYGGAADSVRSSNLSLCCSDSHPASPYGGSCWPPLADSMH
Sbjct: 1 MARRGKKPVVRTLEDLTLDSGYGGAADSVRSSNLSLCCSDSHPASPYGGSCWPPLADSMH 60
Query: 61 SRHNSFDTVNTALVEDSEGLDCAGQHCSRLLPDLDEVPWTLQELEALLLRSRDPRAGPAV 120
SRHNSFDTVNTALVEDSEGLDCAGQHCSRLLPDLDEVPWTLQELEALLLRSRDPRAGPAV
Sbjct: 61 SRHNSFDTVNTALVEDSEGLDCAGQHCSRLLPDLDEVPWTLQELEALLLRSRDPRAGPAV 120
Query: 121 PGGLPKDALAKLSTLVSRALVRIAKEAQRLSLRFAKCTKYEIQSAMEIVLSWGLAAHCTA 180
PGGLPKDALAKLSTLVSRALVRIAKEAQRLSLRFAKCTKYEIQSAMEIVLSWGLAAHCTA
Sbjct: 121 PGGLPKDALAKLSTLVSRALVRIAKEAQRLSLRFAKCTKYEIQSAMEIVLSWGLAAHCTA 180
Query: 181 AALAALSLYNMSSAGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTAC 240
AALAALSLYNMSSAGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTAC
Sbjct: 181 AALAALSLYNMSSAGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTAC 240
Query: 241 MESLFRDIYSRVVASGVPRSCSGPGSGSGSGPGPSSGPGAAPAADKEREAPGGGAASGGA 300
MESLFRDIYSRVVASGVPRSCSGPGSGSGSGPGPSSGPGAAPAADKEREAPGGGAASGGA
Sbjct: 241 MESLFRDIYSRVVASGVPRSCSGPGSGSGSGPGPSSGPGAAPAADKEREAPGGGAASGGA 300
Query: 301 CSAASSASGGSSCCAPPAAAAAAVPPAAAANHHHHHHHALHEAPKFTVETLEHTVNNDSE 360
CSAASSASGGSSCCAPPAAAAAAVPPAAAANHHHHHHHALHEAPKFTVETLEHTVNNDSE
Sbjct: 301 CSAASSASGGSSCCAPPAAAAAAVPPAAAANHHHHHHHALHEAPKFTVETLEHTVNNDSE 360
Query: 361 IWGLLQPYQHLICGKNASGVLCLPDSLNLHRDPQRSNKPGELPMFSQSELRTIEQSLLAT 420
IWGLLQPYQHLICGKNASGVLCLPDSLNLHRDPQRSNKPGELPMFSQSELRTIEQSLLAT
Sbjct: 361 IWGLLQPYQHLICGKNASGVLCLPDSLNLHRDPQRSNKPGELPMFSQSELRTIEQSLLAT 420
Query: 421 RVGSIAELSDLVSRAMHHLQPLNAKHHGNGTPLHHKQGALYWEPEALYTLCYFMHCPQME 480
RVGSIAELSDLVSRAMHHLQPLNAKHHGNGTPLHHKQGALYWEPEALYTLCYFMHCPQME
Sbjct: 421 RVGSIAELSDLVSRAMHHLQPLNAKHHGNGTPLHHKQGALYWEPEALYTLCYFMHCPQME 480
Query: 481 WENPNVEPSKVNLQVERPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGV 540
WENPNVEPSKVNLQVERPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGV
Sbjct: 481 WENPNVEPSKVNLQVERPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGV 540
Query: 541 DCEPRQLRADDCFCASRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTM 600
DCEPRQLRADDCFCASRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTM
Sbjct: 541 DCEPRQLRADDCFCASRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTM 600
Query: 601 SEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLH 660
SEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLH
Sbjct: 601 SEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLH 660
Query: 661 GHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMY 720
GHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMY
Sbjct: 661 GHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMY 720
Query: 721 RNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPP 780
RNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPP
Sbjct: 721 RNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPP 780
Query: 781 PLCASRNSKAKLRALREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWLESLRIAFQQHRRP 840
PLCASRNSKAKLRALREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWLESLRIAFQQHRRP
Sbjct: 781 PLCASRNSKAKLRALREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWLESLRIAFQQHRRP 840
Query: 841 LIQCLLKEFKTIQEEEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHCYGPYPIPK 900
LIQCLLKEFKTIQEEEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHCYGPYPIPK
Sbjct: 841 LIQCLLKEFKTIQEEEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHCYGPYPIPK 900
Query: 901 LTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDG 960
LTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDG
Sbjct: 901 LTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDG 960
Query: 961 TCIEIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAK 1020
TCIEIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAK
Sbjct: 961 TCIEIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAK 1020
Query: 1021 SINTDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGTGQDVL 1080
SINTDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGTGQDVL
Sbjct: 1021 SINTDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGTGQDVL 1080
Query: 1081 QDLQRTLAIRIQSIHLSSSKGSVV 1104
QDLQRTLAIRIQSIHLSSSKGSVV
Sbjct: 1081 QDLQRTLAIRIQSIHLSSSKGSVV 1104
>gi|62953116 BTB (POZ) domain containing 11 isoform b [Homo sapiens]
Length = 641
Score = 1220 bits (3157), Expect = 0.0
Identities = 608/610 (99%), Positives = 610/610 (100%)
Query: 495 VERPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLRADDCFC 554
++RPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLRADDCFC
Sbjct: 32 IQRPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLRADDCFC 91
Query: 555 ASRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVR 614
ASRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVR
Sbjct: 92 ASRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVR 151
Query: 615 GDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGA 674
GDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGA
Sbjct: 152 GDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGA 211
Query: 675 KVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNS 734
KVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNS
Sbjct: 212 KVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNS 271
Query: 735 FSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPPPLCASRNSKAKLRA 794
FSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPPPLCASRNSKAKLRA
Sbjct: 272 FSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPPPLCASRNSKAKLRA 331
Query: 795 LREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWLESLRIAFQQHRRPLIQCLLKEFKTIQE 854
LREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWLESLRIAFQQHRRPLIQCLLKEFKTIQE
Sbjct: 332 LREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWLESLRIAFQQHRRPLIQCLLKEFKTIQE 391
Query: 855 EEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHCYGPYPIPKLTEIKRKQTSRLDP 914
EEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHCYGPYPIPKLTEIKRKQTSRLDP
Sbjct: 392 EEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHCYGPYPIPKLTEIKRKQTSRLDP 451
Query: 915 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDGTCIEIGYVKYSIFQ 974
HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDGTCIEIGYVKYSIFQ
Sbjct: 452 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDGTCIEIGYVKYSIFQ 511
Query: 975 LVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIYNHA 1034
LVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIYNHA
Sbjct: 512 LVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIYNHA 571
Query: 1035 KFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGTGQDVLQDLQRTLAIRIQSI 1094
KFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGTGQDVLQDLQRTLAIRIQSI
Sbjct: 572 KFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGTGQDVLQDLQRTLAIRIQSI 631
Query: 1095 HLSSSKGSVV 1104
HLSSSKGSVV
Sbjct: 632 HLSSSKGSVV 641
>gi|21956639 ankyrin repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 839
Score = 974 bits (2518), Expect = 0.0
Identities = 499/915 (54%), Positives = 648/915 (70%), Gaps = 89/915 (9%)
Query: 194 AGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTACMESLFRDIYSRVV 253
+ GD L RGKSARCGLTFSVGR +RWMVD+R+++RIHE+AAI LTACME+L +I +RV+
Sbjct: 2 SAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVM 61
Query: 254 ASGVPRSCSGPGSGSGSGPGPSSGPGAAPAADKEREAPGGGAASGGACSAASSASGGSSC 313
AS +P GG A GG SA
Sbjct: 62 AS---------------------------------HSPDGGGAGGGEVSA---------- 78
Query: 314 CAPPAAAAAAVPPAAAANHHHHHHHALHEAPKFTVETLEHTVNNDSEIWGLLQPYQHLIC 373
E LE +NND+E+WG+LQPY+HLIC
Sbjct: 79 -----------------------------------EALEMVINNDAELWGVLQPYEHLIC 103
Query: 374 GKNASGVLCLPDSLNLHRDPQRSNKPGELPMFSQSELRTIEQSLLATRVGSIAELSDLVS 433
GKNA+GVL LP + + + ++Q ELRT+EQSLLAT VGSI+ELSDLVS
Sbjct: 104 GKNANGVLSLPAYFSPYNGGSLGHDE-RADAYAQLELRTLEQSLLATCVGSISELSDLVS 162
Query: 434 RAMHHLQPLNAKHHGNGTPLHHKQGA--LYWEPEALYTLCYFMHCPQME-WENPNVEPSK 490
RAMHH+Q + G +Q + W P+AL+TL YF+ CPQME ENPN++P +
Sbjct: 163 RAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPR 222
Query: 491 VNLQVERPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLRAD 550
+ L ERPF++LPPLMEW+RVA+ +A HRRS ++DS D+RQAARLLLPG+DCEPRQL+ +
Sbjct: 223 MTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPE 282
Query: 551 DCFCASRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMY 610
CF + R+LDA A KF QDLGFRMLNCGRTDL+ QA+ LGPDG+NTM +QGMTPLMY
Sbjct: 283 HCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMY 342
Query: 611 ACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLL 670
AC GDEAMVQML+DAGA+L+++V S ++PS+HP++RHWT+LTFAVLHGHI VVQLLL
Sbjct: 343 ACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLL 402
Query: 671 DAGAKVEGS-VEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQ 729
DAGA VEGS V GE++Y+ETPLQLA+A GN+ELVSLLL RGADPL+ + +G+ ++
Sbjct: 403 DAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLH 462
Query: 730 GDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPPPLCAS---R 786
DMN FS +AAHGHRNV RKLL QP++ K+D+LSLEEILAEG + ++ + + R
Sbjct: 463 EDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVR 522
Query: 787 NSKAKLRALREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWLESLRIAFQQHRRPLIQCLL 846
S+ + +AL+EAMY+SAEHGYVD+T+++R++GVPW LH W+ESLR +F Q R ++Q LL
Sbjct: 523 LSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLL 582
Query: 847 KEFKTIQEEEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHCYGPYPIPKLTEIKR 906
++F +I+EEEY EELVT+GL LMF+ILK SKN+ + QQL IFTHCYG PIP + EI++
Sbjct: 583 RDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRK 642
Query: 907 KQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDG---TCI 963
+RLDPHFLNNKEMSDVTFLVEG+ FYAHKVLL TAS RFK L+++K DG I
Sbjct: 643 TLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTI 702
Query: 964 EIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSIN 1023
EI +KY IFQ++MQYLYYGG ES+ I +I+ELLSAA FQL+ALQRHCEI+C+++++
Sbjct: 703 EISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLS 762
Query: 1024 TDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGTGQDVLQDL 1083
++ V+ Y +AK EL+ +CEG+FLK+M L+E +AF+QL+Y ++ + G D LQDL
Sbjct: 763 MESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPLQDL 822
Query: 1084 QRTLAIRIQSIHLSS 1098
Q TLA R+ S++++S
Sbjct: 823 QNTLAERVHSVYITS 837
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 72.0 bits (175), Expect = 3e-12
Identities = 57/159 (35%), Positives = 77/159 (48%), Gaps = 29/159 (18%)
Query: 596 GINTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 654
GINT S + + L AC +G MV+ LL+AGAD HK +H TAL
Sbjct: 363 GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE-------HKTDEMH------TAL 409
Query: 655 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 714
A + GH+ V +LLLD+GA+V + E+PL LAA G+ EL +LL+ERGA+
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADS-----FESPLTLAACGGHVELAALLIERGAN- 463
Query: 715 LIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 753
+ +AA GH + LLAQ
Sbjct: 464 ---------LEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Score = 61.6 bits (148), Expect = 4e-09
Identities = 57/181 (31%), Positives = 82/181 (45%), Gaps = 34/181 (18%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
+ ++++G TPLM A G E MV +LL GA++N + T TALT
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE------------TALTL 511
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 716
A G V L+ AGA +E TPL A+ G+ ELV LL GA
Sbjct: 512 ACCGGFSEVADFLIKAGADIELG--------CSTPLMEASQEGHLELVKYLLASGA---- 559
Query: 717 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL-AQPEKEKSDILSLEEILAEGTDLA 775
N +TT GD + + A +GH +V LL A + +K + + + + EG D A
Sbjct: 560 -----NVHATTATGD-TALTYACENGHTDVADVLLQAGADLDKQEDM---KTILEGIDPA 610
Query: 776 E 776
+
Sbjct: 611 K 611
Score = 61.2 bits (147), Expect = 5e-09
Identities = 49/134 (36%), Positives = 67/134 (50%), Gaps = 19/134 (14%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G D+VK + LL +N+ S G T L YAC G +V++LL+ GA++
Sbjct: 283 GYLDIVK--LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI--------- 331
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
H E H T L A GH+ V ++LLD GA G H E + E+ L LA G
Sbjct: 332 ---EDHNENGH-TPLMEAASAGHVEVARVLLDHGA---GINTHSNE-FKESALTLACYKG 383
Query: 700 NFELVSLLLERGAD 713
+ ++V LLE GAD
Sbjct: 384 HLDMVRFLLEAGAD 397
Score = 49.3 bits (116), Expect = 2e-05
Identities = 47/177 (26%), Positives = 78/177 (44%), Gaps = 37/177 (20%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLL---------------------DAGADLNVEVV 635
+N +E+G + L AC G + Q+LL +G L++ +
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290
Query: 636 STPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLA 695
H TALT+A G + +V++LL+ GA +E E+G TPL A
Sbjct: 291 LLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG-----HTPLMEA 345
Query: 696 AAVGNFELVSLLLERGADPLIGTMYRNGIST-TPQGDMNSFSQAAAHGHRNVFRKLL 751
A+ G+ E+ +LL+ GA GI+T + + ++ + A GH ++ R LL
Sbjct: 346 ASAGHVEVARVLLDHGA----------GINTHSNEFKESALTLACYKGHLDMVRFLL 392
Score = 35.8 bits (81), Expect = 0.23
Identities = 34/106 (32%), Positives = 45/106 (42%), Gaps = 17/106 (16%)
Query: 608 LMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQ 667
L AC GD V+ LLD G +N H E + L A G+ + Q
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNE------------HTEEGE-SLLCLACSAGYYELAQ 255
Query: 668 LLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGAD 713
+LL A VE G+ TPL A++ G ++V LLL AD
Sbjct: 256 VLLAMHANVEDRGNKGDI----TPLMAASSGGYLDIVKLLLLHDAD 297
Score = 34.7 bits (78), Expect = 0.51
Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 14/99 (14%)
Query: 653 ALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGA 712
+L A G + V+ LLD G V EH EE E+ L LA + G +EL +LL
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVN---EHTEE--GESLLCLACSAGYYELAQVLL---- 258
Query: 713 DPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
M+ N +GD+ A++ G+ ++ + LL
Sbjct: 259 -----AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 72.0 bits (175), Expect = 3e-12
Identities = 57/159 (35%), Positives = 77/159 (48%), Gaps = 29/159 (18%)
Query: 596 GINTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 654
GINT S + + L AC +G MV+ LL+AGAD HK +H TAL
Sbjct: 352 GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE-------HKTDEMH------TAL 398
Query: 655 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 714
A + GH+ V +LLLD+GA+V + E+PL LAA G+ EL +LL+ERGA+
Sbjct: 399 MEACMDGHVEVARLLLDSGAQVNMPADS-----FESPLTLAACGGHVELAALLIERGAN- 452
Query: 715 LIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 753
+ +AA GH + LLAQ
Sbjct: 453 ---------LEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
Score = 61.6 bits (148), Expect = 4e-09
Identities = 57/181 (31%), Positives = 82/181 (45%), Gaps = 34/181 (18%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
+ ++++G TPLM A G E MV +LL GA++N + T TALT
Sbjct: 453 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE------------TALTL 500
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 716
A G V L+ AGA +E TPL A+ G+ ELV LL GA
Sbjct: 501 ACCGGFSEVADFLIKAGADIELG--------CSTPLMEASQEGHLELVKYLLASGA---- 548
Query: 717 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL-AQPEKEKSDILSLEEILAEGTDLA 775
N +TT GD + + A +GH +V LL A + +K + + + + EG D A
Sbjct: 549 -----NVHATTATGD-TALTYACENGHTDVADVLLQAGADLDKQEDM---KTILEGIDPA 599
Query: 776 E 776
+
Sbjct: 600 K 600
Score = 61.2 bits (147), Expect = 5e-09
Identities = 49/134 (36%), Positives = 67/134 (50%), Gaps = 19/134 (14%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G D+VK + LL +N+ S G T L YAC G +V++LL+ GA++
Sbjct: 272 GYLDIVK--LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI--------- 320
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
H E H T L A GH+ V ++LLD GA G H E + E+ L LA G
Sbjct: 321 ---EDHNENGH-TPLMEAASAGHVEVARVLLDHGA---GINTHSNE-FKESALTLACYKG 372
Query: 700 NFELVSLLLERGAD 713
+ ++V LLE GAD
Sbjct: 373 HLDMVRFLLEAGAD 386
Score = 52.8 bits (125), Expect = 2e-06
Identities = 46/148 (31%), Positives = 74/148 (50%), Gaps = 29/148 (19%)
Query: 605 MTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIP 664
+TPLM A G +V++LL AD+N + + TALT+A G +
Sbjct: 262 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN-------------TALTYACAGGFVD 308
Query: 665 VVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGI 724
+V++LL+ GA +E E+G TPL AA+ G+ E+ +LL+ GA GI
Sbjct: 309 IVKVLLNEGANIEDHNENG-----HTPLMEAASAGHVEVARVLLDHGA----------GI 353
Query: 725 ST-TPQGDMNSFSQAAAHGHRNVFRKLL 751
+T + + ++ + A GH ++ R LL
Sbjct: 354 NTHSNEFKESALTLACYKGHLDMVRFLL 381
Score = 36.6 bits (83), Expect = 0.13
Identities = 52/201 (25%), Positives = 79/201 (39%), Gaps = 27/201 (13%)
Query: 521 SFSMDSDDV-----RQAARLLLPGVDCEPRQLRADDCFCASRKLDAVAIEAKFKQDLGFR 575
SF +D +D+ + + + L E LR D +R L+A+ A F R
Sbjct: 105 SFILDQEDLDNPVLKTTSEIFLSST-AEGADLRTVDPETQAR-LEALLEAAAFADPEVLR 162
Query: 576 MLNCGRT---DLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNV 632
L + D A++ + + + + L AC GD V+ LLD G +N
Sbjct: 163 RLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNE 222
Query: 633 EVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPL 692
H E + L A G+ + Q+LL A VE G+ TPL
Sbjct: 223 ------------HTEEGE-SLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI----TPL 265
Query: 693 QLAAAVGNFELVSLLLERGAD 713
A++ G ++V LLL AD
Sbjct: 266 MAASSGGYLDIVKLLLLHDAD 286
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 72.0 bits (175), Expect = 3e-12
Identities = 57/159 (35%), Positives = 77/159 (48%), Gaps = 29/159 (18%)
Query: 596 GINTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 654
GINT S + + L AC +G MV+ LL+AGAD HK +H TAL
Sbjct: 363 GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE-------HKTDEMH------TAL 409
Query: 655 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 714
A + GH+ V +LLLD+GA+V + E+PL LAA G+ EL +LL+ERGA+
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADS-----FESPLTLAACGGHVELAALLIERGAN- 463
Query: 715 LIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 753
+ +AA GH + LLAQ
Sbjct: 464 ---------LEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Score = 66.6 bits (161), Expect = 1e-10
Identities = 47/134 (35%), Positives = 68/134 (50%), Gaps = 17/134 (12%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G +++K ++ T S+ G++PLM A + G V++LLD G+D+N ++
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQI----- 1220
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
ET TALT A G VV LLLD A VE + G TPL AA+ G
Sbjct: 1221 -------ETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTG-----LTPLMEAASGG 1268
Query: 700 NFELVSLLLERGAD 713
E+ +LL++GAD
Sbjct: 1269 YAEVGRVLLDKGAD 1282
Score = 63.5 bits (153), Expect = 1e-09
Identities = 49/146 (33%), Positives = 69/146 (47%), Gaps = 27/146 (18%)
Query: 606 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 665
T L AC G E +V +L+ A + H + + +T L A GH+ V
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIE-------------HRDKKGFTPLILAATAGHVGV 1103
Query: 666 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 725
V++LLD G G +E E +TPL LA + G E+V LLL RGA+ +RN
Sbjct: 1104 VEILLDKG----GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGAN----KEHRNVSD 1155
Query: 726 TTPQGDMNSFSQAAAHGHRNVFRKLL 751
TP S AA+ G+ N+ + LL
Sbjct: 1156 YTP------LSLAASGGYVNIIKILL 1175
Score = 62.4 bits (150), Expect = 2e-09
Identities = 60/198 (30%), Positives = 87/198 (43%), Gaps = 27/198 (13%)
Query: 601 SEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLH 660
++ G+TPLM A G + ++LLD GAD+N V P +R TALT A
Sbjct: 1254 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV----------PSSRD-TALTIAADK 1302
Query: 661 GHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMY 720
GH +LL+ GA ++ + G TPL LA+ G+F++V LL++ GAD
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKG-----NTPLWLASNGGHFDVVQLLVQAGAD------- 1350
Query: 721 RNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPP 780
+ + A GH V + L+ + + SDI + I A TD
Sbjct: 1351 ---VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYI-ATITDKELLKKC 1406
Query: 781 PLCASRNSKAKLRALREA 798
C KAK + EA
Sbjct: 1407 HQCVETIVKAKDQQAAEA 1424
Score = 61.2 bits (147), Expect = 5e-09
Identities = 49/134 (36%), Positives = 67/134 (50%), Gaps = 19/134 (14%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G D+VK + LL +N+ S G T L YAC G +V++LL+ GA++
Sbjct: 283 GYLDIVK--LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI--------- 331
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
H E H T L A GH+ V ++LLD GA G H E + E+ L LA G
Sbjct: 332 ---EDHNENGH-TPLMEAASAGHVEVARVLLDHGA---GINTHSNE-FKESALTLACYKG 383
Query: 700 NFELVSLLLERGAD 713
+ ++V LLE GAD
Sbjct: 384 HLDMVRFLLEAGAD 397
Score = 60.8 bits (146), Expect = 7e-09
Identities = 51/155 (32%), Positives = 69/155 (44%), Gaps = 30/155 (19%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
+ ++++G TPLM A G E MV +LL GA++N + T TALT
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE------------TALTL 511
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 716
A G V L+ AGA +E TPL A+ G+ ELV LL GA
Sbjct: 512 ACCGGFSEVADFLIKAGADIELG--------CSTPLMEASQEGHLELVKYLLASGA---- 559
Query: 717 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
N +TT GD + + A +GH +V LL
Sbjct: 560 -----NVHATTATGD-TALTYACENGHTDVADVLL 588
Score = 57.8 bits (138), Expect = 6e-08
Identities = 63/188 (33%), Positives = 80/188 (42%), Gaps = 36/188 (19%)
Query: 586 KQAVSLLGPDG--INTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH--- 639
++ V+LL G IN +E+ T L AC G + L+ AGAD+ + STP
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC-STPLMEA 542
Query: 640 ---------KY-----PSVHPETRHW-TALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGE 684
KY +VH T TALT+A +GH V +LL AGA +E E G
Sbjct: 543 SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG- 601
Query: 685 ENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHR 744
TPL AA G+ V L+ +GA N T D S A A GH
Sbjct: 602 ----RTPLMKAARAGHLCTVQFLISKGA---------NVNRATANNDHTVVSLACAGGHL 648
Query: 745 NVFRKLLA 752
V LLA
Sbjct: 649 AVVELLLA 656
Score = 53.9 bits (128), Expect = 8e-07
Identities = 63/222 (28%), Positives = 88/222 (39%), Gaps = 38/222 (17%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
I ++G TPL+ A G +V++LLD G D+ + T T L+
Sbjct: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKD------------TPLSL 1128
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSE-TPLQLAAAVGNFELVSLLLERGADPL 715
A G VV LLL GA E N S+ TPL LAA+ G ++ +LL GA+
Sbjct: 1129 ACSGGRQEVVDLLLARGANKE------HRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1182
Query: 716 IGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL-------AQPEKEKSDILSLEEIL 768
T + GIS AA +GH + LL AQ E ++ L+L
Sbjct: 1183 SRTGSKLGIS--------PLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQ 1234
Query: 769 AEGTDLAETAPPPLCASRNSKAKLRALREAMYHSAEHGYVDV 810
++ +K L L EA A GY +V
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEA----ASGGYAEV 1272
Score = 49.3 bits (116), Expect = 2e-05
Identities = 47/177 (26%), Positives = 78/177 (44%), Gaps = 37/177 (20%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLL---------------------DAGADLNVEVV 635
+N +E+G + L AC G + Q+LL +G L++ +
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290
Query: 636 STPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLA 695
H TALT+A G + +V++LL+ GA +E E+G TPL A
Sbjct: 291 LLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG-----HTPLMEA 345
Query: 696 AAVGNFELVSLLLERGADPLIGTMYRNGIST-TPQGDMNSFSQAAAHGHRNVFRKLL 751
A+ G+ E+ +LL+ GA GI+T + + ++ + A GH ++ R LL
Sbjct: 346 ASAGHVEVARVLLDHGA----------GINTHSNEFKESALTLACYKGHLDMVRFLL 392
Score = 47.8 bits (112), Expect = 6e-05
Identities = 46/154 (29%), Positives = 65/154 (42%), Gaps = 29/154 (18%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G TD+ V L + SE G TPLM A G VQ L+ GA++N + H
Sbjct: 579 GHTDVAD--VLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH 636
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
T ++ A GH+ VV+LLL GA ++ G T L AA G
Sbjct: 637 ------------TVVSLACAGGHLAVVELLLAHGADPTHRLKDG-----STMLIEAAKGG 679
Query: 700 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMN 733
+ +VS LL+ Y N + + P D++
Sbjct: 680 HTNVVSYLLD----------YPNNVLSVPTTDVS 703
Score = 35.8 bits (81), Expect = 0.23
Identities = 34/106 (32%), Positives = 45/106 (42%), Gaps = 17/106 (16%)
Query: 608 LMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQ 667
L AC GD V+ LLD G +N H E + L A G+ + Q
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNE------------HTEEGE-SLLCLACSAGYYELAQ 255
Query: 668 LLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGAD 713
+LL A VE G+ TPL A++ G ++V LLL AD
Sbjct: 256 VLLAMHANVEDRGNKGDI----TPLMAASSGGYLDIVKLLLLHDAD 297
Score = 34.7 bits (78), Expect = 0.51
Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 14/99 (14%)
Query: 653 ALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGA 712
+L A G + V+ LLD G V EH EE E+ L LA + G +EL +LL
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVN---EHTEE--GESLLCLACSAGYYELAQVLL---- 258
Query: 713 DPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
M+ N +GD+ A++ G+ ++ + LL
Sbjct: 259 -----AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
Score = 34.7 bits (78), Expect = 0.51
Identities = 24/74 (32%), Positives = 36/74 (48%), Gaps = 13/74 (17%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
I+ +++G TPL A G +VQ+L+ AGAD++ + R T L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA-------------ADNRKITPLMS 1364
Query: 657 AVLHGHIPVVQLLL 670
A GH+ VVQ L+
Sbjct: 1365 AFRKGHVKVVQYLV 1378
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 72.0 bits (175), Expect = 3e-12
Identities = 57/159 (35%), Positives = 77/159 (48%), Gaps = 29/159 (18%)
Query: 596 GINTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 654
GINT S + + L AC +G MV+ LL+AGAD HK +H TAL
Sbjct: 363 GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE-------HKTDEMH------TAL 409
Query: 655 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 714
A + GH+ V +LLLD+GA+V + E+PL LAA G+ EL +LL+ERGA+
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADS-----FESPLTLAACGGHVELAALLIERGAN- 463
Query: 715 LIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 753
+ +AA GH + LLAQ
Sbjct: 464 ---------LEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Score = 66.6 bits (161), Expect = 1e-10
Identities = 47/134 (35%), Positives = 68/134 (50%), Gaps = 17/134 (12%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G +++K ++ T S+ G++PLM A + G V++LLD G+D+N ++
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQI----- 1220
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
ET TALT A G VV LLLD A VE + G TPL AA+ G
Sbjct: 1221 -------ETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTG-----LTPLMEAASGG 1268
Query: 700 NFELVSLLLERGAD 713
E+ +LL++GAD
Sbjct: 1269 YAEVGRVLLDKGAD 1282
Score = 63.5 bits (153), Expect = 1e-09
Identities = 49/146 (33%), Positives = 69/146 (47%), Gaps = 27/146 (18%)
Query: 606 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 665
T L AC G E +V +L+ A + H + + +T L A GH+ V
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIE-------------HRDKKGFTPLILAATAGHVGV 1103
Query: 666 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 725
V++LLD G G +E E +TPL LA + G E+V LLL RGA+ +RN
Sbjct: 1104 VEILLDKG----GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGAN----KEHRNVSD 1155
Query: 726 TTPQGDMNSFSQAAAHGHRNVFRKLL 751
TP S AA+ G+ N+ + LL
Sbjct: 1156 YTP------LSLAASGGYVNIIKILL 1175
Score = 62.4 bits (150), Expect = 2e-09
Identities = 60/198 (30%), Positives = 87/198 (43%), Gaps = 27/198 (13%)
Query: 601 SEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLH 660
++ G+TPLM A G + ++LLD GAD+N V P +R TALT A
Sbjct: 1254 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV----------PSSRD-TALTIAADK 1302
Query: 661 GHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMY 720
GH +LL+ GA ++ + G TPL LA+ G+F++V LL++ GAD
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKG-----NTPLWLASNGGHFDVVQLLVQAGAD------- 1350
Query: 721 RNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPP 780
+ + A GH V + L+ + + SDI + I A TD
Sbjct: 1351 ---VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYI-ATITDKELLKKC 1406
Query: 781 PLCASRNSKAKLRALREA 798
C KAK + EA
Sbjct: 1407 HQCVETIVKAKDQQAAEA 1424
Score = 61.2 bits (147), Expect = 5e-09
Identities = 49/134 (36%), Positives = 67/134 (50%), Gaps = 19/134 (14%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G D+VK + LL +N+ S G T L YAC G +V++LL+ GA++
Sbjct: 283 GYLDIVK--LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI--------- 331
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
H E H T L A GH+ V ++LLD GA G H E + E+ L LA G
Sbjct: 332 ---EDHNENGH-TPLMEAASAGHVEVARVLLDHGA---GINTHSNE-FKESALTLACYKG 383
Query: 700 NFELVSLLLERGAD 713
+ ++V LLE GAD
Sbjct: 384 HLDMVRFLLEAGAD 397
Score = 60.8 bits (146), Expect = 7e-09
Identities = 51/155 (32%), Positives = 69/155 (44%), Gaps = 30/155 (19%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
+ ++++G TPLM A G E MV +LL GA++N + T TALT
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE------------TALTL 511
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 716
A G V L+ AGA +E TPL A+ G+ ELV LL GA
Sbjct: 512 ACCGGFSEVADFLIKAGADIELG--------CSTPLMEASQEGHLELVKYLLASGA---- 559
Query: 717 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
N +TT GD + + A +GH +V LL
Sbjct: 560 -----NVHATTATGD-TALTYACENGHTDVADVLL 588
Score = 57.8 bits (138), Expect = 6e-08
Identities = 63/188 (33%), Positives = 80/188 (42%), Gaps = 36/188 (19%)
Query: 586 KQAVSLLGPDG--INTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH--- 639
++ V+LL G IN +E+ T L AC G + L+ AGAD+ + STP
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC-STPLMEA 542
Query: 640 ---------KY-----PSVHPETRHW-TALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGE 684
KY +VH T TALT+A +GH V +LL AGA +E E G
Sbjct: 543 SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG- 601
Query: 685 ENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHR 744
TPL AA G+ V L+ +GA N T D S A A GH
Sbjct: 602 ----RTPLMKAARAGHLCTVQFLISKGA---------NVNRATANNDHTVVSLACAGGHL 648
Query: 745 NVFRKLLA 752
V LLA
Sbjct: 649 AVVELLLA 656
Score = 53.9 bits (128), Expect = 8e-07
Identities = 63/222 (28%), Positives = 88/222 (39%), Gaps = 38/222 (17%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
I ++G TPL+ A G +V++LLD G D+ + T T L+
Sbjct: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKD------------TPLSL 1128
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSE-TPLQLAAAVGNFELVSLLLERGADPL 715
A G VV LLL GA E N S+ TPL LAA+ G ++ +LL GA+
Sbjct: 1129 ACSGGRQEVVDLLLARGANKE------HRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1182
Query: 716 IGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL-------AQPEKEKSDILSLEEIL 768
T + GIS AA +GH + LL AQ E ++ L+L
Sbjct: 1183 SRTGSKLGIS--------PLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQ 1234
Query: 769 AEGTDLAETAPPPLCASRNSKAKLRALREAMYHSAEHGYVDV 810
++ +K L L EA A GY +V
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEA----ASGGYAEV 1272
Score = 49.3 bits (116), Expect = 2e-05
Identities = 47/177 (26%), Positives = 78/177 (44%), Gaps = 37/177 (20%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLL---------------------DAGADLNVEVV 635
+N +E+G + L AC G + Q+LL +G L++ +
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290
Query: 636 STPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLA 695
H TALT+A G + +V++LL+ GA +E E+G TPL A
Sbjct: 291 LLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG-----HTPLMEA 345
Query: 696 AAVGNFELVSLLLERGADPLIGTMYRNGIST-TPQGDMNSFSQAAAHGHRNVFRKLL 751
A+ G+ E+ +LL+ GA GI+T + + ++ + A GH ++ R LL
Sbjct: 346 ASAGHVEVARVLLDHGA----------GINTHSNEFKESALTLACYKGHLDMVRFLL 392
Score = 47.8 bits (112), Expect = 6e-05
Identities = 46/154 (29%), Positives = 65/154 (42%), Gaps = 29/154 (18%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G TD+ V L + SE G TPLM A G VQ L+ GA++N + H
Sbjct: 579 GHTDVAD--VLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH 636
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
T ++ A GH+ VV+LLL GA ++ G T L AA G
Sbjct: 637 ------------TVVSLACAGGHLAVVELLLAHGADPTHRLKDG-----STMLIEAAKGG 679
Query: 700 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMN 733
+ +VS LL+ Y N + + P D++
Sbjct: 680 HTNVVSYLLD----------YPNNVLSVPTTDVS 703
Score = 35.8 bits (81), Expect = 0.23
Identities = 34/106 (32%), Positives = 45/106 (42%), Gaps = 17/106 (16%)
Query: 608 LMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQ 667
L AC GD V+ LLD G +N H E + L A G+ + Q
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNE------------HTEEGE-SLLCLACSAGYYELAQ 255
Query: 668 LLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGAD 713
+LL A VE G+ TPL A++ G ++V LLL AD
Sbjct: 256 VLLAMHANVEDRGNKGDI----TPLMAASSGGYLDIVKLLLLHDAD 297
Score = 34.7 bits (78), Expect = 0.51
Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 14/99 (14%)
Query: 653 ALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGA 712
+L A G + V+ LLD G V EH EE E+ L LA + G +EL +LL
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVN---EHTEE--GESLLCLACSAGYYELAQVLL---- 258
Query: 713 DPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
M+ N +GD+ A++ G+ ++ + LL
Sbjct: 259 -----AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
Score = 34.7 bits (78), Expect = 0.51
Identities = 24/74 (32%), Positives = 36/74 (48%), Gaps = 13/74 (17%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
I+ +++G TPL A G +VQ+L+ AGAD++ + R T L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA-------------ADNRKITPLMS 1364
Query: 657 AVLHGHIPVVQLLL 670
A GH+ VVQ L+
Sbjct: 1365 AFRKGHVKVVQYLV 1378
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 70.5 bits (171), Expect = 8e-12
Identities = 56/159 (35%), Positives = 75/159 (47%), Gaps = 29/159 (18%)
Query: 596 GINTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 654
GINT S + + L AC +G MV+ LL+AGAD HK +H TAL
Sbjct: 392 GINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQE-------HKTDEMH------TAL 438
Query: 655 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 714
A + GH+ V +LLLD+GA+V + E+PL LAA G+ EL +LL+ERGA
Sbjct: 439 MEACMDGHVEVARLLLDSGAQVNMPADS-----FESPLTLAACGGHVELAALLIERGA-- 491
Query: 715 LIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 753
+ +AA GH + LL Q
Sbjct: 492 --------SLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Score = 70.1 bits (170), Expect = 1e-11
Identities = 52/146 (35%), Positives = 71/146 (48%), Gaps = 27/146 (18%)
Query: 606 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 665
T L AC G E +VQ LL+ GA + H + + +T L A GH+ V
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIE-------------HRDKKGFTPLILAATAGHVGV 1131
Query: 666 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 725
V++LLD GA +E E +TPL LA + G E+V LLL RGA+ +RN
Sbjct: 1132 VEILLDNGADIEAQ----SERTKDTPLSLACSGGRQEVVELLLARGAN----KEHRNVSD 1183
Query: 726 TTPQGDMNSFSQAAAHGHRNVFRKLL 751
TP S AA+ G+ N+ + LL
Sbjct: 1184 YTP------LSLAASGGYVNIIKILL 1203
Score = 68.9 bits (167), Expect = 2e-11
Identities = 48/134 (35%), Positives = 69/134 (51%), Gaps = 17/134 (12%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G +++K ++ T S+ G++PLM A + G A V++LLD G+D+N ++
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI----- 1248
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
ET TALT A G VV LLLD A VE + G TPL AA+ G
Sbjct: 1249 -------ETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG-----LTPLMEAASGG 1296
Query: 700 NFELVSLLLERGAD 713
E+ +LL++GAD
Sbjct: 1297 YAEVGRVLLDKGAD 1310
Score = 64.3 bits (155), Expect = 6e-10
Identities = 66/219 (30%), Positives = 96/219 (43%), Gaps = 29/219 (13%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
GRT++V ++ L + ++ G+TPLM A G + ++LLD GAD+N V
Sbjct: 1263 GRTEVV--SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV---- 1316
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
P +R TALT A GH +LL+ GA ++ + G TPL LAA G
Sbjct: 1317 ------PSSRD-TALTIAADKGHYKFCELLIGRGAHIDVRNKKG-----NTPLWLAANGG 1364
Query: 700 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKS 759
+ ++V LL++ GAD + + A GH V R L+ + + S
Sbjct: 1365 HLDVVQLLVQAGAD----------VDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS 1414
Query: 760 DILSLEEILAEGTDLAETAPPPLCASRNSKAKLRALREA 798
D + I A TD LC +AK R EA
Sbjct: 1415 DSECMRYI-ATITDKEMLKKCHLCMESIVQAKDRQAAEA 1452
Score = 63.9 bits (154), Expect = 8e-10
Identities = 52/155 (33%), Positives = 70/155 (45%), Gaps = 30/155 (19%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
+ ++++G TPLM A G E MV +LL GA++N + T TALT
Sbjct: 493 LEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQE------------TALTL 540
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 716
A G + V L+ AGA +E TPL AA G+ ELV LL GA
Sbjct: 541 ACCGGFLEVADFLIKAGADIELG--------CSTPLMEAAQEGHLELVKYLLAAGA---- 588
Query: 717 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
N +TT GD + + A +GH +V LL
Sbjct: 589 -----NVHATTATGD-TALTYACENGHTDVADVLL 617
Score = 61.6 bits (148), Expect = 4e-09
Identities = 63/216 (29%), Positives = 87/216 (40%), Gaps = 38/216 (17%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G +LVK L ++ + G T L YAC G + +LL AGADL
Sbjct: 575 GHLELVKYL--LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE-------- 624
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
H T L A GH+ VQ L+ GA V + N T L LA A G
Sbjct: 625 -----HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT----ANNDHTVLSLACAGG 675
Query: 700 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKS 759
+ +V LLL GADP + + +AA GH +V LL P +
Sbjct: 676 HLAVVELLLAHGADP----------THRLKDGSTMLIEAAKGGHTSVVCYLLDYP----N 721
Query: 760 DILSLEEILAEGTDLAETAPPPLCASRNSKAKLRAL 795
++LS A D+ + PP +R + ++AL
Sbjct: 722 NLLS-----APPPDVTQLTPPSHDLNRAPRVPVQAL 752
Score = 60.1 bits (144), Expect = 1e-08
Identities = 51/147 (34%), Positives = 64/147 (43%), Gaps = 27/147 (18%)
Query: 606 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 665
TPLM A G +V+ LL AGA+++ + TALT+A +GH V
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGD-------------TALTYACENGHTDV 612
Query: 666 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 725
+LL AGA +E E G TPL AA G+ V L+ +GA N
Sbjct: 613 ADVLLQAGADLEHESEGG-----RTPLMKAARAGHVCTVQFLISKGA---------NVNR 658
Query: 726 TTPQGDMNSFSQAAAHGHRNVFRKLLA 752
TT D S A A GH V LLA
Sbjct: 659 TTANNDHTVLSLACAGGHLAVVELLLA 685
Score = 59.3 bits (142), Expect = 2e-08
Identities = 49/136 (36%), Positives = 65/136 (47%), Gaps = 19/136 (13%)
Query: 578 NCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVST 637
N G +VK + L +N S G T L YAC G +V++LL++GA +
Sbjct: 310 NGGHVKIVK--LLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI------- 360
Query: 638 PHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAA 697
H E H T L A GH+ V +LLL+ GA G H E + E+ L LA
Sbjct: 361 -----EDHNENGH-TPLMEAGSAGHVEVARLLLENGA---GINTHSNE-FKESALTLACY 410
Query: 698 VGNFELVSLLLERGAD 713
G+ E+V LLE GAD
Sbjct: 411 KGHLEMVRFLLEAGAD 426
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/148 (33%), Positives = 76/148 (51%), Gaps = 29/148 (19%)
Query: 605 MTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIP 664
+TPLM A G +V++LL AD+N + ST + TALT+A G++
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQS-STGN------------TALTYACAGGYVD 348
Query: 665 VVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGI 724
VV++LL++GA +E E+G TPL A + G+ E+ LLLE GA GI
Sbjct: 349 VVKVLLESGASIEDHNENG-----HTPLMEAGSAGHVEVARLLLENGA----------GI 393
Query: 725 ST-TPQGDMNSFSQAAAHGHRNVFRKLL 751
+T + + ++ + A GH + R LL
Sbjct: 394 NTHSNEFKESALTLACYKGHLEMVRFLL 421
Score = 56.2 bits (134), Expect = 2e-07
Identities = 47/143 (32%), Positives = 65/143 (45%), Gaps = 19/143 (13%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
I ++G TPL+ A G +V++LLD GAD+ + T T L+
Sbjct: 1109 IEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD------------TPLSL 1156
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSE-TPLQLAAAVGNFELVSLLLERGADPL 715
A G VV+LLL GA E N S+ TPL LAA+ G ++ +LL GA+
Sbjct: 1157 ACSGGRQEVVELLLARGANKE------HRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1210
Query: 716 IGTMYRNGISTTPQGDMNSFSQA 738
T + GIS MN + A
Sbjct: 1211 SRTGSKLGISPLMLAAMNGHTAA 1233
Score = 51.2 bits (121), Expect = 5e-06
Identities = 33/77 (42%), Positives = 45/77 (58%), Gaps = 9/77 (11%)
Query: 641 YPSV----HPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAA 696
YP++ E+ H TALT A GH +VQ LL+ GA S+EH ++ TPL LAA
Sbjct: 1070 YPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGA----SIEHRDKK-GFTPLILAA 1124
Query: 697 AVGNFELVSLLLERGAD 713
G+ +V +LL+ GAD
Sbjct: 1125 TAGHVGVVEILLDNGAD 1141
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 70.5 bits (171), Expect = 8e-12
Identities = 56/159 (35%), Positives = 75/159 (47%), Gaps = 29/159 (18%)
Query: 596 GINTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 654
GINT S + + L AC +G MV+ LL+AGAD HK +H TAL
Sbjct: 392 GINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQE-------HKTDEMH------TAL 438
Query: 655 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 714
A + GH+ V +LLLD+GA+V + E+PL LAA G+ EL +LL+ERGA
Sbjct: 439 MEACMDGHVEVARLLLDSGAQVNMPADS-----FESPLTLAACGGHVELAALLIERGA-- 491
Query: 715 LIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 753
+ +AA GH + LL Q
Sbjct: 492 --------SLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Score = 70.1 bits (170), Expect = 1e-11
Identities = 52/146 (35%), Positives = 71/146 (48%), Gaps = 27/146 (18%)
Query: 606 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 665
T L AC G E +VQ LL+ GA + H + + +T L A GH+ V
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIE-------------HRDKKGFTPLILAATAGHVGV 880
Query: 666 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 725
V++LLD GA +E E +TPL LA + G E+V LLL RGA+ +RN
Sbjct: 881 VEILLDNGADIEAQ----SERTKDTPLSLACSGGRQEVVELLLARGAN----KEHRNVSD 932
Query: 726 TTPQGDMNSFSQAAAHGHRNVFRKLL 751
TP S AA+ G+ N+ + LL
Sbjct: 933 YTP------LSLAASGGYVNIIKILL 952
Score = 68.9 bits (167), Expect = 2e-11
Identities = 48/134 (35%), Positives = 69/134 (51%), Gaps = 17/134 (12%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G +++K ++ T S+ G++PLM A + G A V++LLD G+D+N ++
Sbjct: 943 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI----- 997
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
ET TALT A G VV LLLD A VE + G TPL AA+ G
Sbjct: 998 -------ETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG-----LTPLMEAASGG 1045
Query: 700 NFELVSLLLERGAD 713
E+ +LL++GAD
Sbjct: 1046 YAEVGRVLLDKGAD 1059
Score = 64.3 bits (155), Expect = 6e-10
Identities = 66/219 (30%), Positives = 96/219 (43%), Gaps = 29/219 (13%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
GRT++V ++ L + ++ G+TPLM A G + ++LLD GAD+N V
Sbjct: 1012 GRTEVV--SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV---- 1065
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
P +R TALT A GH +LL+ GA ++ + G TPL LAA G
Sbjct: 1066 ------PSSRD-TALTIAADKGHYKFCELLIGRGAHIDVRNKKG-----NTPLWLAANGG 1113
Query: 700 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKS 759
+ ++V LL++ GAD + + A GH V R L+ + + S
Sbjct: 1114 HLDVVQLLVQAGAD----------VDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS 1163
Query: 760 DILSLEEILAEGTDLAETAPPPLCASRNSKAKLRALREA 798
D + I A TD LC +AK R EA
Sbjct: 1164 DSECMRYI-ATITDKEMLKKCHLCMESIVQAKDRQAAEA 1201
Score = 63.9 bits (154), Expect = 8e-10
Identities = 52/155 (33%), Positives = 70/155 (45%), Gaps = 30/155 (19%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
+ ++++G TPLM A G E MV +LL GA++N + T TALT
Sbjct: 493 LEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQE------------TALTL 540
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 716
A G + V L+ AGA +E TPL AA G+ ELV LL GA
Sbjct: 541 ACCGGFLEVADFLIKAGADIELG--------CSTPLMEAAQEGHLELVKYLLAAGA---- 588
Query: 717 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
N +TT GD + + A +GH +V LL
Sbjct: 589 -----NVHATTATGD-TALTYACENGHTDVADVLL 617
Score = 61.6 bits (148), Expect = 4e-09
Identities = 63/216 (29%), Positives = 87/216 (40%), Gaps = 38/216 (17%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G +LVK L ++ + G T L YAC G + +LL AGADL
Sbjct: 575 GHLELVKYL--LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE-------- 624
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
H T L A GH+ VQ L+ GA V + N T L LA A G
Sbjct: 625 -----HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT----ANNDHTVLSLACAGG 675
Query: 700 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKS 759
+ +V LLL GADP + + +AA GH +V LL P +
Sbjct: 676 HLAVVELLLAHGADP----------THRLKDGSTMLIEAAKGGHTSVVCYLLDYP----N 721
Query: 760 DILSLEEILAEGTDLAETAPPPLCASRNSKAKLRAL 795
++LS A D+ + PP +R + ++AL
Sbjct: 722 NLLS-----APPPDVTQLTPPSHDLNRAPRVPVQAL 752
Score = 60.1 bits (144), Expect = 1e-08
Identities = 51/147 (34%), Positives = 64/147 (43%), Gaps = 27/147 (18%)
Query: 606 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 665
TPLM A G +V+ LL AGA+++ + TALT+A +GH V
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGD-------------TALTYACENGHTDV 612
Query: 666 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 725
+LL AGA +E E G TPL AA G+ V L+ +GA N
Sbjct: 613 ADVLLQAGADLEHESEGG-----RTPLMKAARAGHVCTVQFLISKGA---------NVNR 658
Query: 726 TTPQGDMNSFSQAAAHGHRNVFRKLLA 752
TT D S A A GH V LLA
Sbjct: 659 TTANNDHTVLSLACAGGHLAVVELLLA 685
Score = 59.3 bits (142), Expect = 2e-08
Identities = 49/136 (36%), Positives = 65/136 (47%), Gaps = 19/136 (13%)
Query: 578 NCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVST 637
N G +VK + L +N S G T L YAC G +V++LL++GA +
Sbjct: 310 NGGHVKIVK--LLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI------- 360
Query: 638 PHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAA 697
H E H T L A GH+ V +LLL+ GA G H E + E+ L LA
Sbjct: 361 -----EDHNENGH-TPLMEAGSAGHVEVARLLLENGA---GINTHSNE-FKESALTLACY 410
Query: 698 VGNFELVSLLLERGAD 713
G+ E+V LLE GAD
Sbjct: 411 KGHLEMVRFLLEAGAD 426
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/148 (33%), Positives = 76/148 (51%), Gaps = 29/148 (19%)
Query: 605 MTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIP 664
+TPLM A G +V++LL AD+N + ST + TALT+A G++
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQS-STGN------------TALTYACAGGYVD 348
Query: 665 VVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGI 724
VV++LL++GA +E E+G TPL A + G+ E+ LLLE GA GI
Sbjct: 349 VVKVLLESGASIEDHNENG-----HTPLMEAGSAGHVEVARLLLENGA----------GI 393
Query: 725 ST-TPQGDMNSFSQAAAHGHRNVFRKLL 751
+T + + ++ + A GH + R LL
Sbjct: 394 NTHSNEFKESALTLACYKGHLEMVRFLL 421
Score = 56.2 bits (134), Expect = 2e-07
Identities = 47/143 (32%), Positives = 65/143 (45%), Gaps = 19/143 (13%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
I ++G TPL+ A G +V++LLD GAD+ + T T L+
Sbjct: 858 IEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD------------TPLSL 905
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSE-TPLQLAAAVGNFELVSLLLERGADPL 715
A G VV+LLL GA E N S+ TPL LAA+ G ++ +LL GA+
Sbjct: 906 ACSGGRQEVVELLLARGANKE------HRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 959
Query: 716 IGTMYRNGISTTPQGDMNSFSQA 738
T + GIS MN + A
Sbjct: 960 SRTGSKLGISPLMLAAMNGHTAA 982
Score = 51.2 bits (121), Expect = 5e-06
Identities = 33/77 (42%), Positives = 45/77 (58%), Gaps = 9/77 (11%)
Query: 641 YPSV----HPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAA 696
YP++ E+ H TALT A GH +VQ LL+ GA S+EH ++ TPL LAA
Sbjct: 819 YPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGA----SIEHRDKK-GFTPLILAA 873
Query: 697 AVGNFELVSLLLERGAD 713
G+ +V +LL+ GAD
Sbjct: 874 TAGHVGVVEILLDNGAD 890
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 68.9 bits (167), Expect = 2e-11
Identities = 38/152 (25%), Positives = 78/152 (51%), Gaps = 6/152 (3%)
Query: 918 NNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDGTCIEIGYVKYSIFQLVM 977
+N + +D+ FLV+G+ YAHKVLL F+ SS N+ +E+ Y +++ +
Sbjct: 389 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFR---SSLEDNEDDIVEMSEFSYPVYRAFL 445
Query: 978 QYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIYNHAKFL 1037
+YLY +S+ + E + LL A F++ L++ C+ + I +N + + + A
Sbjct: 446 EYLY---TDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKY 502
Query: 1038 GVTELSAYCEGYFLKNMMVLIENEAFKQLLYD 1069
+L +C + + ++ V+ + F ++ +D
Sbjct: 503 DAQDLEEFCFRFCINHLTVVTQTSGFAEMDHD 534
>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 623
Score = 67.8 bits (164), Expect = 5e-11
Identities = 41/155 (26%), Positives = 73/155 (47%), Gaps = 4/155 (2%)
Query: 916 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKAL-LSSKPTNDGTCIEIGYVKYSIFQ 974
F + +D+ +VEG F HK++L T S F+A+ +S + T + + V + Q
Sbjct: 24 FYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQ 83
Query: 975 LVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIYNHA 1034
+++ Y Y G +L + ++ + +L A F Q+E + + C K IN +NCV + + A
Sbjct: 84 IIITYAYTG---NLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFA 140
Query: 1035 KFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYD 1069
EL + + +AF QL +D
Sbjct: 141 DLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHD 175
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 64.7 bits (156), Expect = 5e-10
Identities = 44/191 (23%), Positives = 83/191 (43%), Gaps = 4/191 (2%)
Query: 891 HCYGPYPIPKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKA 950
H Y + LT + +Q + + E+ D+ V +AHKV+L + SP FKA
Sbjct: 3 HTSPTYMLANLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKA 62
Query: 951 LLSSKPTN-DGTCIEIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEA 1009
+ + + + + +E + + Q +++Y Y G ++ I + + LL AA Q++
Sbjct: 63 MFTGNLSEKENSEVEFQCIDETALQAIVEYAYTG---TVFISQDTVESLLPAANLLQIKL 119
Query: 1010 LQRHCEIICAKSINTDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYD 1069
+ + C ++ NC+ I A+ G +L Y +N + + E F +L +
Sbjct: 120 VLKECCAFLESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHA 179
Query: 1070 KNGEGTGQDVL 1080
E D L
Sbjct: 180 DLDEIVSNDCL 190
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 62.8 bits (151), Expect = 2e-09
Identities = 52/160 (32%), Positives = 72/160 (45%), Gaps = 33/160 (20%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
+N +G T L+ A G +V+ LLD GA++N H + TAL+
Sbjct: 670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVN-------------HEDVDGRTALSV 716
Query: 657 AVL-----HGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERG 711
A L GH VV LL+D GA+V+ + G TPL +AA G+ ++V LLLE G
Sbjct: 717 AALCVPASKGHASVVSLLIDRGAEVDHCDKDG-----MTPLLVAAYEGHVDVVDLLLEGG 771
Query: 712 ADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
AD + T AA+ GH +V LL
Sbjct: 772 AD----------VDHTDNNGRTPLLAAASMGHASVVNTLL 801
Score = 62.4 bits (150), Expect = 2e-09
Identities = 55/167 (32%), Positives = 74/167 (44%), Gaps = 30/167 (17%)
Query: 589 VSLLGPDG--INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHP 646
VSLL G ++ + GMTPL+ A G +V +LL+ GAD++ H
Sbjct: 731 VSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-------------HT 777
Query: 647 ETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSL 706
+ T L A GH VV LL GA V+ G T L +A+A GN E+V
Sbjct: 778 DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG-----RTVLSIASAQGNVEVVRT 832
Query: 707 LLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 753
LL+RG D +R+ TP AA GHR + L+ Q
Sbjct: 833 LLDRGLD----ENHRDDAGWTP------LHMAAFEGHRLICEALIEQ 869
Score = 59.3 bits (142), Expect = 2e-08
Identities = 45/154 (29%), Positives = 69/154 (44%), Gaps = 28/154 (18%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
+ +G T L +C +G MVQ+L+ AD+N + +AL
Sbjct: 972 VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAA-------------DNEKRSALQS 1018
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 716
A GH+ VVQLL++ GA V+ + G T L +AA G+ ++V +LLE GADP
Sbjct: 1019 AAWQGHVKVVQLLIEHGAVVDHTCNQGA-----TALCIAAQEGHIDVVQVLLEHGADP-- 1071
Query: 717 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKL 750
+ Q + AA +GH + + L
Sbjct: 1072 --------NHADQFGRTAMRVAAKNGHSQIIKLL 1097
Score = 54.3 bits (129), Expect = 6e-07
Identities = 52/172 (30%), Positives = 73/172 (42%), Gaps = 30/172 (17%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G D+V VS G D + G TPL A +G +V L+ GA++N
Sbjct: 556 GSLDVVNLLVSR-GAD-LEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN-------- 605
Query: 640 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 699
H + WTAL A GH VV LL AG KV+ + + S T L+ AA G
Sbjct: 606 -----HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCA-----DADSRTALRAAAWGG 655
Query: 700 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
+ ++V LL+ GA+ ++ + AA GHR + LL
Sbjct: 656 HEDIVLNLLQHGAE----------VNKADNEGRTALIAAAYMGHREIVEHLL 697
Score = 53.9 bits (128), Expect = 8e-07
Identities = 46/184 (25%), Positives = 75/184 (40%), Gaps = 37/184 (20%)
Query: 578 NCGRTDLVKQA---------VSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGA 628
N GRT L+ A L ++++ +G T L A +G+ +V+ LLD G
Sbjct: 779 NNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL 838
Query: 629 DLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYS 688
D N H + WT L A GH + + L++ GA+ + +N
Sbjct: 839 DEN-------------HRDDAGWTPLHMAAFEGHRLICEALIEQGART-----NEIDNDG 880
Query: 689 ETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFR 748
P LA+ G+++ V +LLE ++ I N+ AA GHR++
Sbjct: 881 RIPFILASQEGHYDCVQILLEN----------KSNIDQRGYDGRNALRVAALEGHRDIVE 930
Query: 749 KLLA 752
L +
Sbjct: 931 LLFS 934
Score = 45.8 bits (107), Expect = 2e-04
Identities = 44/146 (30%), Positives = 61/146 (41%), Gaps = 23/146 (15%)
Query: 606 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 665
T L A G E +V LL GA++N + TAL A GH +
Sbjct: 646 TALRAAAWGGHEDIVLNLLQHGAEVN-------------KADNEGRTALIAAAYMGHREI 692
Query: 666 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 725
V+ LLD GA+V G S L + A+ G+ +VSLL++RGA+ +
Sbjct: 693 VEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE----------VD 742
Query: 726 TTPQGDMNSFSQAAAHGHRNVFRKLL 751
+ M AA GH +V LL
Sbjct: 743 HCDKDGMTPLLVAAYEGHVDVVDLLL 768
Score = 35.0 bits (79), Expect = 0.39
Identities = 39/154 (25%), Positives = 60/154 (38%), Gaps = 29/154 (18%)
Query: 603 QGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGH 662
QG T L A G +VQ+LL+ GAD N H + TA+ A +GH
Sbjct: 1044 QGATALCIAAQEGHIDVVQVLLEHGADPN-------------HADQFGRTAMRVAAKNGH 1090
Query: 663 IPVVQLLLDAGA-KVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYR 721
+++LL GA + G + PLQ ++ ++ SL T+
Sbjct: 1091 SQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSS----KVQSL-----------TIKS 1135
Query: 722 NGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPE 755
N +T GDM + +G + F P+
Sbjct: 1136 NSSGSTGGGDMQPSLRGLPNGPTHAFSSPSESPD 1169
>gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo
sapiens]
Length = 313
Score = 62.4 bits (150), Expect = 2e-09
Identities = 51/150 (34%), Positives = 69/150 (46%), Gaps = 28/150 (18%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
IN E+G TPLM+A G A+V+ LL GAD P + + R +AL+
Sbjct: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD------------PQLLGKGRE-SALSL 221
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 716
A G+ +V++LLD G V +G TPL A + + V +LLE GADP I
Sbjct: 222 ACSKGYTDIVKMLLDCGVDVNEYDWNG-----GTPLLYAVHGNHVKCVKMLLESGADPTI 276
Query: 717 GTMYRNGISTTPQGDMNSFSQAAAHGHRNV 746
T NS A A G+R+V
Sbjct: 277 ET----------DSGYNSMDLAVALGYRSV 296
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 61.6 bits (148), Expect = 4e-09
Identities = 65/255 (25%), Positives = 113/255 (44%), Gaps = 32/255 (12%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
+N + +G TP+ AC G E +V++LL G D++++ W L +
Sbjct: 530 VNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDA-------------WLPLHY 576
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 716
A GH+P+V+LL AK G + + TPL LAA G++ + +L++ +D +
Sbjct: 577 AAWQGHLPIVKLL----AKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNV 632
Query: 717 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL---AQPEKEKSDILSLEEILAEGTD 773
++ ++ TP AA GH + R LL A E SD + + A
Sbjct: 633 CSL----LAQTP------LHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGH 682
Query: 774 LAETAPPPLCASRNSKAKLRALREAMYHSAEHGYVDVTIDIRSIGVPWTL-HTWLESLRI 832
LA T + + A+ + A++ +A HG+ +V ++ S V L +L +
Sbjct: 683 LA-TVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHL 741
Query: 833 AFQQHRRPLIQCLLK 847
A Q ++ LL+
Sbjct: 742 AAQGRHAQTVETLLR 756
Score = 45.4 bits (106), Expect = 3e-04
Identities = 44/164 (26%), Positives = 63/164 (38%), Gaps = 28/164 (17%)
Query: 591 LLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRH 650
LL N + +G TPL A R +V++LL +N + +
Sbjct: 458 LLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAK-------------DEDQ 504
Query: 651 WTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLER 710
WTAL FA +G +LLL+ A V G TP+ +A G +V +LL R
Sbjct: 505 WTALHFAAQNGDESSTRLLLEKNASVNEVDFEG-----RTPMHVACQHGQENIVRILLRR 559
Query: 711 GADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQP 754
G D +S + AA GH + + L QP
Sbjct: 560 GVD----------VSLQGKDAWLPLHYAAWQGHLPIVKLLAKQP 593
>gi|67906195 ankyrin repeat and sterile alpha motif domain
containing 6 [Homo sapiens]
Length = 871
Score = 61.2 bits (147), Expect = 5e-09
Identities = 57/170 (33%), Positives = 82/170 (48%), Gaps = 23/170 (13%)
Query: 540 VDCEPRQL--RADDCFCASRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGI 597
+DC+ R L D K D E K + D+ F L G LVK+ ++ P +
Sbjct: 266 LDCKHRDLVDYLDPLTTVRPKTD----EEKRRPDI-FHALKMGNFQLVKE-IADEDPSHV 319
Query: 598 NTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFA 657
N ++ G TPLM A V G A+VQ+L++ AD++ K SVH WTAL A
Sbjct: 320 NLVNGDGATPLMLAAVTGQLALVQLLVERHADVD--------KQDSVH----GWTALMQA 367
Query: 658 VLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLL 707
HG+ +V+ LL+ GA V ++G Y+ L + + ELV LL
Sbjct: 368 TYHGNKEIVKYLLNQGADVTLRAKNG---YTAFDLVMLLNDPDTELVRLL 414
Score = 57.8 bits (138), Expect = 6e-08
Identities = 51/162 (31%), Positives = 69/162 (42%), Gaps = 22/162 (13%)
Query: 594 PDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTA 653
P ++ E G T L +A G E +V+ LL GA +N S H W+A
Sbjct: 68 PVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVN----SRNHY---------GWSA 114
Query: 654 LTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGA- 712
L A GH+ V LLLD GA V + + + L +A+ G+ +V LLLE GA
Sbjct: 115 LMQAARFGHVSVAHLLLDHGADV-----NAQNRLGASVLTVASRGGHLGVVKLLLEAGAF 169
Query: 713 ---DPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
G G S D+ + A HGH V R L+
Sbjct: 170 VDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLM 211
Score = 53.1 bits (126), Expect = 1e-06
Identities = 40/126 (31%), Positives = 59/126 (46%), Gaps = 19/126 (15%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPS--------VHPET 648
+N + G + L A G +V++LL+AGA ++ H +PS E
Sbjct: 137 VNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVD-------HHHPSGEQLGLGGSRDEP 189
Query: 649 RHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLL 708
TAL A+ HGH VV+LL++ GA H +PL LAA G + L+
Sbjct: 190 LDITALMAAIQHGHEAVVRLLMEWGA----DPNHAARTVGWSPLMLAALTGRLGVAQQLV 245
Query: 709 ERGADP 714
E+GA+P
Sbjct: 246 EKGANP 251
Score = 45.1 bits (105), Expect = 4e-04
Identities = 50/179 (27%), Positives = 69/179 (38%), Gaps = 42/179 (23%)
Query: 600 MSEQGMTP----LMYACVRGDEAMVQMLLDAGADLNVEVVSTPH---------------- 639
M E G+ P L+ AC +GD + LL+ GA E + P
Sbjct: 1 MGEGGLPPAFQLLLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAA 60
Query: 640 -------KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPL 692
P + TAL FA GH P+V+ LL GA V + +Y + L
Sbjct: 61 AAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASV-----NSRNHYGWSAL 115
Query: 693 QLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
AA G+ + LLL+ GAD + R G S + A+ GH V + LL
Sbjct: 116 MQAARFGHVSVAHLLLDHGAD--VNAQNRLGASV--------LTVASRGGHLGVVKLLL 164
Score = 37.0 bits (84), Expect = 0.10
Identities = 47/185 (25%), Positives = 77/185 (41%), Gaps = 40/185 (21%)
Query: 593 GPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGAD---LNV---------------EV 634
G D + G +PLM A + G + Q L++ GA+ L+V ++
Sbjct: 214 GADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDL 273
Query: 635 VSTPHKYPSVHPET---RHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETP 691
V +V P+T + + A+ G+ +V+ + D V +G+ TP
Sbjct: 274 VDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLV-NGD---GATP 329
Query: 692 LQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFS---QAAAHGHRNVFR 748
L LAA G LV LL+ER AD Q ++ ++ QA HG++ + +
Sbjct: 330 LMLAAVTGQLALVQLLVERHAD------------VDKQDSVHGWTALMQATYHGNKEIVK 377
Query: 749 KLLAQ 753
LL Q
Sbjct: 378 YLLNQ 382
Score = 33.1 bits (74), Expect = 1.5
Identities = 22/62 (35%), Positives = 32/62 (51%), Gaps = 4/62 (6%)
Query: 652 TALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERG 711
T L A + G + +VQLL++ A V+ + + T L A GN E+V LL +G
Sbjct: 328 TPLMLAAVTGQLALVQLLVERHADVDKQ----DSVHGWTALMQATYHGNKEIVKYLLNQG 383
Query: 712 AD 713
AD
Sbjct: 384 AD 385
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 61.2 bits (147), Expect = 5e-09
Identities = 48/128 (37%), Positives = 61/128 (47%), Gaps = 17/128 (13%)
Query: 598 NTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFA 657
N ++ G T L AC+ G VQ L+ G LN P Y WT L A
Sbjct: 523 NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLN------PRDYCG-------WTPLHEA 569
Query: 658 VLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIG 717
+GH+ +V+ LLD GA V+ G E TPL A G+FE+ LLLERGA +
Sbjct: 570 CNYGHLEIVRFLLDHGAAVDDPGGQGCEGI--TPLHDALNCGHFEVAELLLERGASVTLR 627
Query: 718 TMYRNGIS 725
T R G+S
Sbjct: 628 T--RKGLS 633
Score = 31.6 bits (70), Expect = 4.3
Identities = 33/94 (35%), Positives = 39/94 (41%), Gaps = 16/94 (17%)
Query: 583 DLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYP 642
DLV+Q L N G TPL AC G +V+ LLD GA V P
Sbjct: 547 DLVRQGHPL------NPRDYCGWTPLHEACNYGHLEIVRFLLDHGA-----AVDDPG--- 592
Query: 643 SVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKV 676
T L A+ GH V +LLL+ GA V
Sbjct: 593 --GQGCEGITPLHDALNCGHFEVAELLLERGASV 624
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 61.2 bits (147), Expect = 5e-09
Identities = 46/128 (35%), Positives = 64/128 (50%), Gaps = 20/128 (15%)
Query: 587 QAVSLLGPDG--INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSV 644
Q V LL G +N +QG TPLM A G V LL GA + +
Sbjct: 1081 QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL------------ 1128
Query: 645 HPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELV 704
+ TAL++A L GH+ VV+ L+D GA + +H ++N TPL LAA G+ E+V
Sbjct: 1129 -MDKEGLTALSWACLKGHLSVVRSLVDNGA----ATDHADKN-GRTPLDLAAFYGDAEVV 1182
Query: 705 SLLLERGA 712
L++ GA
Sbjct: 1183 QFLVDHGA 1190
Score = 49.3 bits (116), Expect = 2e-05
Identities = 37/117 (31%), Positives = 56/117 (47%), Gaps = 20/117 (17%)
Query: 597 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 656
I M ++G+T L +AC++G ++V+ L+D GA + H + T L
Sbjct: 1126 IALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD-------------HADKNGRTPLDL 1172
Query: 657 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYS-ETPLQLAAAVGNFELVSLLLERGA 712
A +G VVQ L+D GA +E +YS PL A N +V LL++GA
Sbjct: 1173 AAFYGDAEVVQFLVDHGAMIE------HVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
Score = 47.4 bits (111), Expect = 8e-05
Identities = 45/148 (30%), Positives = 63/148 (42%), Gaps = 28/148 (18%)
Query: 604 GMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHI 663
G T L A RG + ++LL+ GA + P R L V GH
Sbjct: 1034 GETALTAAAGRGKLEVCRLLLEQGAAV-------------AQPNRRGAVPLFSTVRQGHW 1080
Query: 664 PVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNG 723
+V LLL GA V + + G TPL +AA+ G+ V LL +GA I M + G
Sbjct: 1081 QIVDLLLTHGADVNMADKQG-----RTPLMMAASEGHLGTVDFLLAQGAS--IALMDKEG 1133
Query: 724 ISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
++ + S A GH +V R L+
Sbjct: 1134 LT--------ALSWACLKGHLSVVRSLV 1153
Score = 43.9 bits (102), Expect = 8e-04
Identities = 57/201 (28%), Positives = 76/201 (37%), Gaps = 44/201 (21%)
Query: 580 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 639
G T++V A+ L ++ SE G+TPL YA G ++V +L A V+ +
Sbjct: 896 GYTEMV--ALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRA--KVDHLDKNG 951
Query: 640 KYPSVHPETR------------HWT-----------------ALTFAVLHGHIPVVQLLL 670
+ VH R WT AL A G+ +V LL
Sbjct: 952 QCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLL 1011
Query: 671 DAGAKVEGSVEHGEEN-----YSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNG-- 723
D K E VE + N + ET L AA G E+ LLLE+GA + R G
Sbjct: 1012 DLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGA--AVAQPNRRGAV 1069
Query: 724 --ISTTPQGDMNSFSQAAAHG 742
ST QG HG
Sbjct: 1070 PLFSTVRQGHWQIVDLLLTHG 1090
Score = 35.0 bits (79), Expect = 0.39
Identities = 30/91 (32%), Positives = 43/91 (47%), Gaps = 15/91 (16%)
Query: 661 GHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMY 720
G+ +V LLL+ GA V+ S E G TPL AAA G +V LL ++ A + +
Sbjct: 896 GYTEMVALLLEFGANVDASSESGL-----TPLGYAAAAGYLSIVVLLCKKRAK--VDHLD 948
Query: 721 RNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
+NG + AA GH V + L+
Sbjct: 949 KNG--------QCALVHAALRGHLEVVKFLI 971
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 60.1 bits (144), Expect = 1e-08
Identities = 34/138 (24%), Positives = 66/138 (47%), Gaps = 4/138 (2%)
Query: 934 FYAHKVLLFTASPRFKALLSS-KPTNDGTCIEIGYVKYSIFQLVMQYLYYGGPESLLIKN 992
F H+V++ +AS FKA+ + D CI++ V + ++ ++Y L +
Sbjct: 105 FPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTA---KLSLNM 161
Query: 993 NEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIYNHAKFLGVTELSAYCEGYFLK 1052
+ + + L AA F Q+ + C++ + DNCV++ A +TE+ Y + LK
Sbjct: 162 DNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLK 221
Query: 1053 NMMVLIENEAFKQLLYDK 1070
N L+ F +L +++
Sbjct: 222 NFPALLSTGEFLKLPFER 239
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 59.7 bits (143), Expect = 1e-08
Identities = 46/128 (35%), Positives = 65/128 (50%), Gaps = 20/128 (15%)
Query: 587 QAVSLLGPDG--INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSV 644
Q V LL G +N +QG TPLM A G + V+ LL GA L+
Sbjct: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALS------------- 1164
Query: 645 HPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELV 704
+ +AL++A L GH VVQ L++ GA ++ + ++G TPL LAA G+ E V
Sbjct: 1165 SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG-----RTPLDLAAFYGDAETV 1219
Query: 705 SLLLERGA 712
L+E+GA
Sbjct: 1220 LYLVEKGA 1227
Score = 45.4 bits (106), Expect = 3e-04
Identities = 47/165 (28%), Positives = 68/165 (41%), Gaps = 18/165 (10%)
Query: 589 VSLLGPDGINT--MSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHP 646
V LL G+ + ++G L+++ +RG ++Q LL E P + ++
Sbjct: 976 VCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTC------EWSPGPPQPGTLRK 1029
Query: 647 ETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSL 706
ALT A GH VVQ LL + E V + + ET L AA G E+ L
Sbjct: 1030 SHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCEL 1089
Query: 707 LLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
LL GA +S T + + AA GH + R LL
Sbjct: 1090 LLGHGA----------AVSRTNRRGVPPLFCAARQGHWQIVRLLL 1124
Score = 45.1 bits (105), Expect = 4e-04
Identities = 44/146 (30%), Positives = 62/146 (42%), Gaps = 23/146 (15%)
Query: 608 LMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQ 667
L A G ++VQ LL + VEV T + TALT A G + V +
Sbjct: 1037 LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGE--------TALTAAAGRGKLEVCE 1088
Query: 668 LLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTT 727
LLL GA V + G PL AA G++++V LLLERG D ++ +
Sbjct: 1089 LLLGHGAAVSRTNRRGVP-----PLFCAARQGHWQIVRLLLERGCD----------VNLS 1133
Query: 728 PQGDMNSFSQAAAHGHRNVFRKLLAQ 753
+ AA GH + LL++
Sbjct: 1134 DKQGRTPLMVAACEGHLSTVEFLLSK 1159
Score = 37.4 bits (85), Expect = 0.079
Identities = 23/51 (45%), Positives = 32/51 (62%), Gaps = 5/51 (9%)
Query: 661 GHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERG 711
GH VV LLL+ GA ++G+ E+G T L AAA G+ +LV LL ++G
Sbjct: 938 GHEEVVTLLLEFGACLDGTSENG-----MTALCYAAAAGHMKLVCLLTKKG 983
Score = 31.6 bits (70), Expect = 4.3
Identities = 43/187 (22%), Positives = 80/187 (42%), Gaps = 33/187 (17%)
Query: 591 LLGPDGINTMSEQ-GMTPLMYACVR---GDEAMVQMLLDAGADLNVEVVSTPHKYPSVHP 646
+LG +N +E P++ CV+ G E +V +LL+ GA L+
Sbjct: 912 ILGGANVNYRTEVLNNAPIL--CVQSHLGHEEVVTLLLEFGACLD-------------GT 956
Query: 647 ETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSL 706
TAL +A GH+ +V LL G +V+ + G + L +A G+ +++
Sbjct: 957 SENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKG-----QCALVHSALRGHGDILQY 1011
Query: 707 LLE---RGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILS 763
LL P GT+ ++ + + AA+ GH +V + LL ++ + ++
Sbjct: 1012 LLTCEWSPGPPQPGTLRKS------HALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNG 1065
Query: 764 LEEILAE 770
+ + E
Sbjct: 1066 TDTLWGE 1072
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 59.7 bits (143), Expect = 1e-08
Identities = 46/128 (35%), Positives = 65/128 (50%), Gaps = 20/128 (15%)
Query: 587 QAVSLLGPDG--INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSV 644
Q V LL G +N +QG TPLM A G + V+ LL GA L+
Sbjct: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALS------------- 1172
Query: 645 HPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELV 704
+ +AL++A L GH VVQ L++ GA ++ + ++G TPL LAA G+ E V
Sbjct: 1173 SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG-----RTPLDLAAFYGDAETV 1227
Query: 705 SLLLERGA 712
L+E+GA
Sbjct: 1228 LYLVEKGA 1235
Score = 45.4 bits (106), Expect = 3e-04
Identities = 47/165 (28%), Positives = 68/165 (41%), Gaps = 18/165 (10%)
Query: 589 VSLLGPDGINT--MSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHP 646
V LL G+ + ++G L+++ +RG ++Q LL E P + ++
Sbjct: 984 VCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTC------EWSPGPPQPGTLRK 1037
Query: 647 ETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSL 706
ALT A GH VVQ LL + E V + + ET L AA G E+ L
Sbjct: 1038 SHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCEL 1097
Query: 707 LLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 751
LL GA +S T + + AA GH + R LL
Sbjct: 1098 LLGHGA----------AVSRTNRRGVPPLFCAARQGHWQIVRLLL 1132
Score = 45.1 bits (105), Expect = 4e-04
Identities = 44/146 (30%), Positives = 62/146 (42%), Gaps = 23/146 (15%)
Query: 608 LMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQ 667
L A G ++VQ LL + VEV T + TALT A G + V +
Sbjct: 1045 LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGE--------TALTAAAGRGKLEVCE 1096
Query: 668 LLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTT 727
LLL GA V + G PL AA G++++V LLLERG D ++ +
Sbjct: 1097 LLLGHGAAVSRTNRRGVP-----PLFCAARQGHWQIVRLLLERGCD----------VNLS 1141
Query: 728 PQGDMNSFSQAAAHGHRNVFRKLLAQ 753
+ AA GH + LL++
Sbjct: 1142 DKQGRTPLMVAACEGHLSTVEFLLSK 1167
Score = 37.4 bits (85), Expect = 0.079
Identities = 23/51 (45%), Positives = 32/51 (62%), Gaps = 5/51 (9%)
Query: 661 GHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERG 711
GH VV LLL+ GA ++G+ E+G T L AAA G+ +LV LL ++G
Sbjct: 946 GHEEVVTLLLEFGACLDGTSENG-----MTALCYAAAAGHMKLVCLLTKKG 991
Score = 31.6 bits (70), Expect = 4.3
Identities = 43/187 (22%), Positives = 80/187 (42%), Gaps = 33/187 (17%)
Query: 591 LLGPDGINTMSEQ-GMTPLMYACVR---GDEAMVQMLLDAGADLNVEVVSTPHKYPSVHP 646
+LG +N +E P++ CV+ G E +V +LL+ GA L+
Sbjct: 920 ILGGANVNYRTEVLNNAPIL--CVQSHLGHEEVVTLLLEFGACLD-------------GT 964
Query: 647 ETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSL 706
TAL +A GH+ +V LL G +V+ + G + L +A G+ +++
Sbjct: 965 SENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKG-----QCALVHSALRGHGDILQY 1019
Query: 707 LLE---RGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILS 763
LL P GT+ ++ + + AA+ GH +V + LL ++ + ++
Sbjct: 1020 LLTCEWSPGPPQPGTLRKS------HALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNG 1073
Query: 764 LEEILAE 770
+ + E
Sbjct: 1074 TDTLWGE 1080
>gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isoform a
[Homo sapiens]
Length = 534
Score = 59.7 bits (143), Expect = 1e-08
Identities = 32/115 (27%), Positives = 61/115 (53%), Gaps = 4/115 (3%)
Query: 917 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDGTCIEIGYVKYSIFQL 975
L + +DVT VEGR F H+++L S F+++ +S I + V S+FQL
Sbjct: 55 LEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQL 114
Query: 976 VMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDI 1030
++ Y+Y+G ++ ++ E+ E+ + +QL +L C A+++ NC+ +
Sbjct: 115 LVDYIYHG---TVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQV 166
>gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isoform b
[Homo sapiens]
Length = 518
Score = 59.7 bits (143), Expect = 1e-08
Identities = 32/115 (27%), Positives = 61/115 (53%), Gaps = 4/115 (3%)
Query: 917 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDGTCIEIGYVKYSIFQL 975
L + +DVT VEGR F H+++L S F+++ +S I + V S+FQL
Sbjct: 39 LEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQL 98
Query: 976 VMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDI 1030
++ Y+Y+G ++ ++ E+ E+ + +QL +L C A+++ NC+ +
Sbjct: 99 LVDYIYHG---TVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQV 150
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 58.9 bits (141), Expect = 3e-08
Identities = 42/120 (35%), Positives = 63/120 (52%), Gaps = 18/120 (15%)
Query: 595 DGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 654
D +N +E+G T L A +RGD ++ L+ GAD+NV+ + WTAL
Sbjct: 159 DKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVK-------------DFAGWTAL 205
Query: 655 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 714
A G+ V + LL AGA+V G ++ +TPL AA G++++V LLL G +P
Sbjct: 206 HEACNRGYYDVAKQLLAAGAEVN---TKGLDD--DTPLHDAANNGHYKVVKLLLRYGGNP 260
>gi|28461129 ankyrin repeat and MYND domain containing 2 [Homo
sapiens]
Length = 441
Score = 58.9 bits (141), Expect = 3e-08
Identities = 40/125 (32%), Positives = 64/125 (51%), Gaps = 19/125 (15%)
Query: 585 VKQAVSLLGPDGI--NTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYP 642
V++A +LL + N + E GMTPLM+A +G M ++LL GAD+N
Sbjct: 25 VQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVN----------- 73
Query: 643 SVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFE 702
H +TAL FA L G+ + ++L+AGA+ + + T Q+AA VG +
Sbjct: 74 -CHQHEHGYTALMFAALSGNKDITWVMLEAGAETD-----VVNSVGRTAAQMAAFVGQHD 127
Query: 703 LVSLL 707
V+++
Sbjct: 128 CVTII 132
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 58.9 bits (141), Expect = 3e-08
Identities = 40/173 (23%), Positives = 78/173 (45%), Gaps = 4/173 (2%)
Query: 895 PYPIPKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSS 954
P +P +++ +QT + ++E+ DV +V + YAH+V+L SP F+A+ +
Sbjct: 40 PARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTG 99
Query: 955 K-PTNDGTCIEIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRH 1013
+ + T + I + +L++ + Y + ++ + LL AA QL +Q
Sbjct: 100 ELAESRQTEVVIRDIDERAMELLIDFAY---TSQITVEEGNVQTLLPAACLLQLAEIQEA 156
Query: 1014 CEIICAKSINTDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQL 1066
C + ++ NC+ I A EL + + N ++E+E F L
Sbjct: 157 CCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLL 209
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/160 (31%), Positives = 70/160 (43%), Gaps = 31/160 (19%)
Query: 594 PDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTA 653
PD N E TPL AC R + V++L+ AD N H R WTA
Sbjct: 150 PDISNKSRE---TPLYKACERKNAEAVKILVQHNADTN-------------HRCNRGWTA 193
Query: 654 LTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGAD 713
L +V + V+Q+L+ GAKVE + Y TPL +AA G E + L + GAD
Sbjct: 194 LHESVSRNDLEVMQILVSGGAKVE-----SKNAYGITPLFVAAQSGQLEALRFLAKYGAD 248
Query: 714 PLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 753
I+T + ++ +A + H V LL+Q
Sbjct: 249 ----------INTQASDNASALYEACKNEHEEVVEFLLSQ 278
Score = 44.7 bits (104), Expect = 5e-04
Identities = 37/151 (24%), Positives = 63/151 (41%), Gaps = 21/151 (13%)
Query: 592 LGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHW 651
L P+ ++ + L +A V + ++LL GAD N +V+S
Sbjct: 351 LAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVIS--------------- 395
Query: 652 TALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERG 711
L A+ HG + +QLLLD GA ++ + + + P + A+ L+ L++ G
Sbjct: 396 -PLLVAIRHGCLRTMQLLLDHGANIDAYI---ATHPTAFPATIMFAMKCLSLLKFLMDLG 451
Query: 712 AD--PLIGTMYRNGISTTPQGDMNSFSQAAA 740
D P +Y NG + F+ A A
Sbjct: 452 CDGEPCFSCLYGNGPHPPAPQPSSRFNDAPA 482
Score = 43.9 bits (102), Expect = 8e-04
Identities = 40/163 (24%), Positives = 66/163 (40%), Gaps = 26/163 (15%)
Query: 554 CASRKLDAVAIEAKFKQDLGFRML--------NCGRTDLVKQAVSLLGPDGINTMSEQGM 605
C + +AV I + D R + R DL + + G + + + G+
Sbjct: 165 CERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGI 224
Query: 606 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 665
TPL A G ++ L GAD+N + + + +AL A + H V
Sbjct: 225 TPLFVAAQSGQLEALRFLAKYGADINTQA-------------SDNASALYEACKNEHEEV 271
Query: 666 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLL 708
V+ LL GA + + G PL +A+ GN+ +V +LL
Sbjct: 272 VEFLLSQGADANKTNKDG-----LLPLHIASKKGNYRIVQMLL 309
Score = 39.7 bits (91), Expect = 0.016
Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 12/110 (10%)
Query: 604 GMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHI 663
G++PL A R + +++ LL A D+N + + E R +AL FAV++ ++
Sbjct: 321 GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL----YEDRRSSALYFAVVNNNV 376
Query: 664 PVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGAD 713
+LLL GA V +PL +A G + LLL+ GA+
Sbjct: 377 YATELLLQHGADPNRDV--------ISPLLVAIRHGCLRTMQLLLDHGAN 418
Score = 32.7 bits (73), Expect = 1.9
Identities = 22/62 (35%), Positives = 30/62 (48%), Gaps = 5/62 (8%)
Query: 652 TALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERG 711
TA+ A GH+ + LL AGA+ + S ETPL A N E V +L++
Sbjct: 126 TAVYLATCRGHLDCLLSLLQAGAEPDIS-----NKSRETPLYKACERKNAEAVKILVQHN 180
Query: 712 AD 713
AD
Sbjct: 181 AD 182
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 58.2 bits (139), Expect = 4e-08
Identities = 40/120 (33%), Positives = 63/120 (52%), Gaps = 18/120 (15%)
Query: 595 DGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 654
D +N +E+G TPL A +RGD V+ L+ GA++NV+ + WT L
Sbjct: 153 DKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVK-------------DFAGWTPL 199
Query: 655 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 714
A G+ V ++L+ AGA V G ++ +TPL +A+ G+ ++V LLL G +P
Sbjct: 200 HEACNVGYYDVAKILIAAGADVN---TQGLDD--DTPLHDSASSGHRDIVKLLLRHGGNP 254
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 58.2 bits (139), Expect = 4e-08
Identities = 40/120 (33%), Positives = 63/120 (52%), Gaps = 18/120 (15%)
Query: 595 DGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 654
D +N +E+G TPL A +RGD V+ L+ GA++NV+ + WT L
Sbjct: 176 DKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVK-------------DFAGWTPL 222
Query: 655 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 714
A G+ V ++L+ AGA V G ++ +TPL +A+ G+ ++V LLL G +P
Sbjct: 223 HEACNVGYYDVAKILIAAGADVN---TQGLDD--DTPLHDSASSGHRDIVKLLLRHGGNP 277
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 58.2 bits (139), Expect = 4e-08
Identities = 45/160 (28%), Positives = 77/160 (48%), Gaps = 8/160 (5%)
Query: 907 KQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDGTCIEI- 965
+QT + ++L +K++ DV + R AH+++L + S F A+ ++ + EI
Sbjct: 158 EQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTND-VREARQEEIK 216
Query: 966 --GYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSIN 1023
G S++ L+ QY Y G E +K + I LLS A QL + C K ++
Sbjct: 217 MEGVEPNSLWSLI-QYAYTGRLE---LKEDNIECLLSTACLLQLSQVVEACCKFLMKQLH 272
Query: 1024 TDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAF 1063
NC+ I + A G T+L Y +++ M +I N+ F
Sbjct: 273 PSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEF 312
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,723,260
Number of Sequences: 37866
Number of extensions: 2172182
Number of successful extensions: 23540
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 420
Number of HSP's successfully gapped in prelim test: 587
Number of HSP's that attempted gapping in prelim test: 15174
Number of HSP's gapped (non-prelim): 5572
length of query: 1104
length of database: 18,247,518
effective HSP length: 113
effective length of query: 991
effective length of database: 13,968,660
effective search space: 13842942060
effective search space used: 13842942060
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.