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Search of human proteins with 62953116
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62953116 BTB (POZ) domain containing 11 isoform b [Homo
sapiens]
(641 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62953116 BTB (POZ) domain containing 11 isoform b [Homo sapiens] 1286 0.0
gi|65786661 BTB (POZ) domain containing 11 isoform a [Homo sapiens] 1220 0.0
gi|21956639 ankyrin repeat and BTB (POZ) domain containing 2 [Ho... 770 0.0
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 72 2e-12
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 72 2e-12
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 72 2e-12
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 72 2e-12
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 70 5e-12
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 70 5e-12
gi|4557445 regulator of chromosome condensation and BTB domain c... 69 1e-11
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom... 68 3e-11
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 65 3e-10
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 63 1e-09
gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo sapi... 62 1e-09
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 62 2e-09
gi|67906195 ankyrin repeat and sterile alpha motif domain contai... 61 3e-09
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 61 3e-09
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 61 3e-09
gi|45643138 kelch-like 13 [Homo sapiens] 60 6e-09
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 60 8e-09
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 60 8e-09
gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isof... 60 8e-09
gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isof... 60 8e-09
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 59 1e-08
gi|28461129 ankyrin repeat and MYND domain containing 2 [Homo sa... 59 1e-08
gi|40807500 kelch-like 20 [Homo sapiens] 59 1e-08
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 59 2e-08
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 58 2e-08
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 58 2e-08
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 58 2e-08
>gi|62953116 BTB (POZ) domain containing 11 isoform b [Homo sapiens]
Length = 641
Score = 1286 bits (3327), Expect = 0.0
Identities = 641/641 (100%), Positives = 641/641 (100%)
Query: 1 MRKLRPKDSREPAPGSPVRSGCLQRLSHYSGIQRPFLVLPPLMEWIRVAVAHAGHRRSFS 60
MRKLRPKDSREPAPGSPVRSGCLQRLSHYSGIQRPFLVLPPLMEWIRVAVAHAGHRRSFS
Sbjct: 1 MRKLRPKDSREPAPGSPVRSGCLQRLSHYSGIQRPFLVLPPLMEWIRVAVAHAGHRRSFS 60
Query: 61 MDSDDVRQAARLLLPGVDCEPRQLRADDCFCASRKLDAVAIEAKFKQDLGFRMLNCGRTD 120
MDSDDVRQAARLLLPGVDCEPRQLRADDCFCASRKLDAVAIEAKFKQDLGFRMLNCGRTD
Sbjct: 61 MDSDDVRQAARLLLPGVDCEPRQLRADDCFCASRKLDAVAIEAKFKQDLGFRMLNCGRTD 120
Query: 121 LVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPS 180
LVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPS
Sbjct: 121 LVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPS 180
Query: 181 VHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFEL 240
VHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFEL
Sbjct: 181 VHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFEL 240
Query: 241 VSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILS 300
VSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILS
Sbjct: 241 VSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILS 300
Query: 301 LEEILAEGTDLAETAPPPLCASRNSKAKLRALREAMYHSAEHGYVDVTIDIRSIGVPWTL 360
LEEILAEGTDLAETAPPPLCASRNSKAKLRALREAMYHSAEHGYVDVTIDIRSIGVPWTL
Sbjct: 301 LEEILAEGTDLAETAPPPLCASRNSKAKLRALREAMYHSAEHGYVDVTIDIRSIGVPWTL 360
Query: 361 HTWLESLRIAFQQHRRPLIQCLLKEFKTIQEEEYTEELVTQGLPLMFEILKASKNEVISQ 420
HTWLESLRIAFQQHRRPLIQCLLKEFKTIQEEEYTEELVTQGLPLMFEILKASKNEVISQ
Sbjct: 361 HTWLESLRIAFQQHRRPLIQCLLKEFKTIQEEEYTEELVTQGLPLMFEILKASKNEVISQ 420
Query: 421 QLCVIFTHCYGPYPIPKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFT 480
QLCVIFTHCYGPYPIPKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFT
Sbjct: 421 QLCVIFTHCYGPYPIPKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFT 480
Query: 481 ASPRFKALLSSKPTNDGTCIEIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAK 540
ASPRFKALLSSKPTNDGTCIEIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAK
Sbjct: 481 ASPRFKALLSSKPTNDGTCIEIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAK 540
Query: 541 FFQLEALQRHCEIICAKSINTDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAF 600
FFQLEALQRHCEIICAKSINTDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAF
Sbjct: 541 FFQLEALQRHCEIICAKSINTDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAF 600
Query: 601 KQLLYDKNGEGTGQDVLQDLQRTLAIRIQSIHLSSSKGSVV 641
KQLLYDKNGEGTGQDVLQDLQRTLAIRIQSIHLSSSKGSVV
Sbjct: 601 KQLLYDKNGEGTGQDVLQDLQRTLAIRIQSIHLSSSKGSVV 641
>gi|65786661 BTB (POZ) domain containing 11 isoform a [Homo sapiens]
Length = 1104
Score = 1220 bits (3157), Expect = 0.0
Identities = 608/610 (99%), Positives = 610/610 (100%)
Query: 32 IQRPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLRADDCFC 91
++RPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLRADDCFC
Sbjct: 495 VERPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLRADDCFC 554
Query: 92 ASRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVR 151
ASRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVR
Sbjct: 555 ASRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVR 614
Query: 152 GDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGA 211
GDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGA
Sbjct: 615 GDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGA 674
Query: 212 KVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNS 271
KVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNS
Sbjct: 675 KVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNS 734
Query: 272 FSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPPPLCASRNSKAKLRA 331
FSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPPPLCASRNSKAKLRA
Sbjct: 735 FSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPPPLCASRNSKAKLRA 794
Query: 332 LREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWLESLRIAFQQHRRPLIQCLLKEFKTIQE 391
LREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWLESLRIAFQQHRRPLIQCLLKEFKTIQE
Sbjct: 795 LREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWLESLRIAFQQHRRPLIQCLLKEFKTIQE 854
Query: 392 EEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHCYGPYPIPKLTEIKRKQTSRLDP 451
EEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHCYGPYPIPKLTEIKRKQTSRLDP
Sbjct: 855 EEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHCYGPYPIPKLTEIKRKQTSRLDP 914
Query: 452 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDGTCIEIGYVKYSIFQ 511
HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDGTCIEIGYVKYSIFQ
Sbjct: 915 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDGTCIEIGYVKYSIFQ 974
Query: 512 LVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIYNHA 571
LVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIYNHA
Sbjct: 975 LVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIYNHA 1034
Query: 572 KFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGTGQDVLQDLQRTLAIRIQSI 631
KFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGTGQDVLQDLQRTLAIRIQSI
Sbjct: 1035 KFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGTGQDVLQDLQRTLAIRIQSI 1094
Query: 632 HLSSSKGSVV 641
HLSSSKGSVV
Sbjct: 1095 HLSSSKGSVV 1104
>gi|21956639 ankyrin repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 839
Score = 770 bits (1988), Expect = 0.0
Identities = 371/610 (60%), Positives = 485/610 (79%), Gaps = 7/610 (1%)
Query: 33 QRPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLRADDCFCA 92
+RPF++LPPLMEW+RVA+ +A HRRS ++DS D+RQAARLLLPG+DCEPRQL+ + CF +
Sbjct: 228 ERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSS 287
Query: 93 SRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRG 152
R+LDA A KF QDLGFRMLNCGRTDL+ QA+ LGPDG+NTM +QGMTPLMYAC G
Sbjct: 288 FRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAG 347
Query: 153 DEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAK 212
DEAMVQML+DAGA+L+++V S ++PS+HP++RHWT+LTFAVLHGHI VVQLLLDAGA
Sbjct: 348 DEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAH 407
Query: 213 VEGS-VEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNS 271
VEGS V GE++Y+ETPLQLA+A GN+ELVSLLL RGADPL+ + +G+ ++ DMN
Sbjct: 408 VEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNC 467
Query: 272 FSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPPPLCAS---RNSKAK 328
FS +AAHGHRNV RKLL QP++ K+D+LSLEEILAEG + ++ + + R S+ +
Sbjct: 468 FSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTR 527
Query: 329 LRALREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWLESLRIAFQQHRRPLIQCLLKEFKT 388
+AL+EAMY+SAEHGYVD+T+++R++GVPW LH W+ESLR +F Q R ++Q LL++F +
Sbjct: 528 TKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSS 587
Query: 389 IQEEEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHCYGPYPIPKLTEIKRKQTSR 448
I+EEEY EELVT+GL LMF+ILK SKN+ + QQL IFTHCYG PIP + EI++ +R
Sbjct: 588 IREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPAR 647
Query: 449 LDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDG---TCIEIGYV 505
LDPHFLNNKEMSDVTFLVEG+ FYAHKVLL TAS RFK L+++K DG IEI +
Sbjct: 648 LDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDM 707
Query: 506 KYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCV 565
KY IFQ++MQYLYYGG ES+ I +I+ELLSAA FQL+ALQRHCEI+C+++++ ++ V
Sbjct: 708 KYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAV 767
Query: 566 DIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGTGQDVLQDLQRTLA 625
+ Y +AK EL+ +CEG+FLK+M L+E +AF+QL+Y ++ + G D LQDLQ TLA
Sbjct: 768 NTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPLQDLQNTLA 827
Query: 626 IRIQSIHLSS 635
R+ S++++S
Sbjct: 828 ERVHSVYITS 837
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 72.0 bits (175), Expect = 2e-12
Identities = 57/159 (35%), Positives = 77/159 (48%), Gaps = 29/159 (18%)
Query: 133 GINTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 191
GINT S + + L AC +G MV+ LL+AGAD HK +H TAL
Sbjct: 363 GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE-------HKTDEMH------TAL 409
Query: 192 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 251
A + GH+ V +LLLD+GA+V + E+PL LAA G+ EL +LL+ERGA+
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADS-----FESPLTLAACGGHVELAALLIERGAN- 463
Query: 252 LIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 290
+ +AA GH + LLAQ
Sbjct: 464 ---------LEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Score = 61.6 bits (148), Expect = 2e-09
Identities = 57/181 (31%), Positives = 82/181 (45%), Gaps = 34/181 (18%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
+ ++++G TPLM A G E MV +LL GA++N + T TALT
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE------------TALTL 511
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 253
A G V L+ AGA +E TPL A+ G+ ELV LL GA
Sbjct: 512 ACCGGFSEVADFLIKAGADIELG--------CSTPLMEASQEGHLELVKYLLASGA---- 559
Query: 254 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL-AQPEKEKSDILSLEEILAEGTDLA 312
N +TT GD + + A +GH +V LL A + +K + + + + EG D A
Sbjct: 560 -----NVHATTATGD-TALTYACENGHTDVADVLLQAGADLDKQEDM---KTILEGIDPA 610
Query: 313 E 313
+
Sbjct: 611 K 611
Score = 61.2 bits (147), Expect = 3e-09
Identities = 49/134 (36%), Positives = 67/134 (50%), Gaps = 19/134 (14%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G D+VK + LL +N+ S G T L YAC G +V++LL+ GA++
Sbjct: 283 GYLDIVK--LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI--------- 331
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
H E H T L A GH+ V ++LLD GA G H E + E+ L LA G
Sbjct: 332 ---EDHNENGH-TPLMEAASAGHVEVARVLLDHGA---GINTHSNE-FKESALTLACYKG 383
Query: 237 NFELVSLLLERGAD 250
+ ++V LLE GAD
Sbjct: 384 HLDMVRFLLEAGAD 397
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/177 (26%), Positives = 78/177 (44%), Gaps = 37/177 (20%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLL---------------------DAGADLNVEVV 172
+N +E+G + L AC G + Q+LL +G L++ +
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290
Query: 173 STPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLA 232
H TALT+A G + +V++LL+ GA +E E+G TPL A
Sbjct: 291 LLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG-----HTPLMEA 345
Query: 233 AAVGNFELVSLLLERGADPLIGTMYRNGIST-TPQGDMNSFSQAAAHGHRNVFRKLL 288
A+ G+ E+ +LL+ GA GI+T + + ++ + A GH ++ R LL
Sbjct: 346 ASAGHVEVARVLLDHGA----------GINTHSNEFKESALTLACYKGHLDMVRFLL 392
Score = 35.8 bits (81), Expect = 0.12
Identities = 34/106 (32%), Positives = 45/106 (42%), Gaps = 17/106 (16%)
Query: 145 LMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQ 204
L AC GD V+ LLD G +N H E + L A G+ + Q
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNE------------HTEEGE-SLLCLACSAGYYELAQ 255
Query: 205 LLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGAD 250
+LL A VE G+ TPL A++ G ++V LLL AD
Sbjct: 256 VLLAMHANVEDRGNKGDI----TPLMAASSGGYLDIVKLLLLHDAD 297
Score = 34.7 bits (78), Expect = 0.28
Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 14/99 (14%)
Query: 190 ALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGA 249
+L A G + V+ LLD G V EH EE E+ L LA + G +EL +LL
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVN---EHTEE--GESLLCLACSAGYYELAQVLL---- 258
Query: 250 DPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
M+ N +GD+ A++ G+ ++ + LL
Sbjct: 259 -----AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 72.0 bits (175), Expect = 2e-12
Identities = 57/159 (35%), Positives = 77/159 (48%), Gaps = 29/159 (18%)
Query: 133 GINTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 191
GINT S + + L AC +G MV+ LL+AGAD HK +H TAL
Sbjct: 352 GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE-------HKTDEMH------TAL 398
Query: 192 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 251
A + GH+ V +LLLD+GA+V + E+PL LAA G+ EL +LL+ERGA+
Sbjct: 399 MEACMDGHVEVARLLLDSGAQVNMPADS-----FESPLTLAACGGHVELAALLIERGAN- 452
Query: 252 LIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 290
+ +AA GH + LLAQ
Sbjct: 453 ---------LEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
Score = 61.6 bits (148), Expect = 2e-09
Identities = 57/181 (31%), Positives = 82/181 (45%), Gaps = 34/181 (18%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
+ ++++G TPLM A G E MV +LL GA++N + T TALT
Sbjct: 453 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE------------TALTL 500
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 253
A G V L+ AGA +E TPL A+ G+ ELV LL GA
Sbjct: 501 ACCGGFSEVADFLIKAGADIELG--------CSTPLMEASQEGHLELVKYLLASGA---- 548
Query: 254 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL-AQPEKEKSDILSLEEILAEGTDLA 312
N +TT GD + + A +GH +V LL A + +K + + + + EG D A
Sbjct: 549 -----NVHATTATGD-TALTYACENGHTDVADVLLQAGADLDKQEDM---KTILEGIDPA 599
Query: 313 E 313
+
Sbjct: 600 K 600
Score = 61.2 bits (147), Expect = 3e-09
Identities = 49/134 (36%), Positives = 67/134 (50%), Gaps = 19/134 (14%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G D+VK + LL +N+ S G T L YAC G +V++LL+ GA++
Sbjct: 272 GYLDIVK--LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI--------- 320
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
H E H T L A GH+ V ++LLD GA G H E + E+ L LA G
Sbjct: 321 ---EDHNENGH-TPLMEAASAGHVEVARVLLDHGA---GINTHSNE-FKESALTLACYKG 372
Query: 237 NFELVSLLLERGAD 250
+ ++V LLE GAD
Sbjct: 373 HLDMVRFLLEAGAD 386
Score = 52.8 bits (125), Expect = 1e-06
Identities = 46/148 (31%), Positives = 74/148 (50%), Gaps = 29/148 (19%)
Query: 142 MTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIP 201
+TPLM A G +V++LL AD+N + + TALT+A G +
Sbjct: 262 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN-------------TALTYACAGGFVD 308
Query: 202 VVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGI 261
+V++LL+ GA +E E+G TPL AA+ G+ E+ +LL+ GA GI
Sbjct: 309 IVKVLLNEGANIEDHNENG-----HTPLMEAASAGHVEVARVLLDHGA----------GI 353
Query: 262 ST-TPQGDMNSFSQAAAHGHRNVFRKLL 288
+T + + ++ + A GH ++ R LL
Sbjct: 354 NTHSNEFKESALTLACYKGHLDMVRFLL 381
Score = 36.6 bits (83), Expect = 0.073
Identities = 52/201 (25%), Positives = 79/201 (39%), Gaps = 27/201 (13%)
Query: 58 SFSMDSDDV-----RQAARLLLPGVDCEPRQLRADDCFCASRKLDAVAIEAKFKQDLGFR 112
SF +D +D+ + + + L E LR D +R L+A+ A F R
Sbjct: 105 SFILDQEDLDNPVLKTTSEIFLSST-AEGADLRTVDPETQAR-LEALLEAAAFADPEVLR 162
Query: 113 MLNCGRT---DLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNV 169
L + D A++ + + + + L AC GD V+ LLD G +N
Sbjct: 163 RLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNE 222
Query: 170 EVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPL 229
H E + L A G+ + Q+LL A VE G+ TPL
Sbjct: 223 ------------HTEEGE-SLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI----TPL 265
Query: 230 QLAAAVGNFELVSLLLERGAD 250
A++ G ++V LLL AD
Sbjct: 266 MAASSGGYLDIVKLLLLHDAD 286
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 72.0 bits (175), Expect = 2e-12
Identities = 57/159 (35%), Positives = 77/159 (48%), Gaps = 29/159 (18%)
Query: 133 GINTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 191
GINT S + + L AC +G MV+ LL+AGAD HK +H TAL
Sbjct: 363 GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE-------HKTDEMH------TAL 409
Query: 192 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 251
A + GH+ V +LLLD+GA+V + E+PL LAA G+ EL +LL+ERGA+
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADS-----FESPLTLAACGGHVELAALLIERGAN- 463
Query: 252 LIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 290
+ +AA GH + LLAQ
Sbjct: 464 ---------LEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Score = 66.6 bits (161), Expect = 7e-11
Identities = 47/134 (35%), Positives = 68/134 (50%), Gaps = 17/134 (12%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G +++K ++ T S+ G++PLM A + G V++LLD G+D+N ++
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQI----- 1220
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
ET TALT A G VV LLLD A VE + G TPL AA+ G
Sbjct: 1221 -------ETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTG-----LTPLMEAASGG 1268
Query: 237 NFELVSLLLERGAD 250
E+ +LL++GAD
Sbjct: 1269 YAEVGRVLLDKGAD 1282
Score = 63.5 bits (153), Expect = 6e-10
Identities = 49/146 (33%), Positives = 69/146 (47%), Gaps = 27/146 (18%)
Query: 143 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 202
T L AC G E +V +L+ A + H + + +T L A GH+ V
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIE-------------HRDKKGFTPLILAATAGHVGV 1103
Query: 203 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 262
V++LLD G G +E E +TPL LA + G E+V LLL RGA+ +RN
Sbjct: 1104 VEILLDKG----GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGAN----KEHRNVSD 1155
Query: 263 TTPQGDMNSFSQAAAHGHRNVFRKLL 288
TP S AA+ G+ N+ + LL
Sbjct: 1156 YTP------LSLAASGGYVNIIKILL 1175
Score = 62.4 bits (150), Expect = 1e-09
Identities = 60/198 (30%), Positives = 87/198 (43%), Gaps = 27/198 (13%)
Query: 138 SEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLH 197
++ G+TPLM A G + ++LLD GAD+N V P +R TALT A
Sbjct: 1254 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV----------PSSRD-TALTIAADK 1302
Query: 198 GHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMY 257
GH +LL+ GA ++ + G TPL LA+ G+F++V LL++ GAD
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKG-----NTPLWLASNGGHFDVVQLLVQAGAD------- 1350
Query: 258 RNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPP 317
+ + A GH V + L+ + + SDI + I A TD
Sbjct: 1351 ---VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYI-ATITDKELLKKC 1406
Query: 318 PLCASRNSKAKLRALREA 335
C KAK + EA
Sbjct: 1407 HQCVETIVKAKDQQAAEA 1424
Score = 61.2 bits (147), Expect = 3e-09
Identities = 49/134 (36%), Positives = 67/134 (50%), Gaps = 19/134 (14%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G D+VK + LL +N+ S G T L YAC G +V++LL+ GA++
Sbjct: 283 GYLDIVK--LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI--------- 331
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
H E H T L A GH+ V ++LLD GA G H E + E+ L LA G
Sbjct: 332 ---EDHNENGH-TPLMEAASAGHVEVARVLLDHGA---GINTHSNE-FKESALTLACYKG 383
Query: 237 NFELVSLLLERGAD 250
+ ++V LLE GAD
Sbjct: 384 HLDMVRFLLEAGAD 397
Score = 60.8 bits (146), Expect = 4e-09
Identities = 51/155 (32%), Positives = 69/155 (44%), Gaps = 30/155 (19%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
+ ++++G TPLM A G E MV +LL GA++N + T TALT
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE------------TALTL 511
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 253
A G V L+ AGA +E TPL A+ G+ ELV LL GA
Sbjct: 512 ACCGGFSEVADFLIKAGADIELG--------CSTPLMEASQEGHLELVKYLLASGA---- 559
Query: 254 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
N +TT GD + + A +GH +V LL
Sbjct: 560 -----NVHATTATGD-TALTYACENGHTDVADVLL 588
Score = 57.8 bits (138), Expect = 3e-08
Identities = 63/188 (33%), Positives = 80/188 (42%), Gaps = 36/188 (19%)
Query: 123 KQAVSLLGPDG--INTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH--- 176
++ V+LL G IN +E+ T L AC G + L+ AGAD+ + STP
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC-STPLMEA 542
Query: 177 ---------KY-----PSVHPETRHW-TALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGE 221
KY +VH T TALT+A +GH V +LL AGA +E E G
Sbjct: 543 SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG- 601
Query: 222 ENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHR 281
TPL AA G+ V L+ +GA N T D S A A GH
Sbjct: 602 ----RTPLMKAARAGHLCTVQFLISKGA---------NVNRATANNDHTVVSLACAGGHL 648
Query: 282 NVFRKLLA 289
V LLA
Sbjct: 649 AVVELLLA 656
Score = 53.9 bits (128), Expect = 4e-07
Identities = 63/222 (28%), Positives = 88/222 (39%), Gaps = 38/222 (17%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
I ++G TPL+ A G +V++LLD G D+ + T T L+
Sbjct: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKD------------TPLSL 1128
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSE-TPLQLAAAVGNFELVSLLLERGADPL 252
A G VV LLL GA E N S+ TPL LAA+ G ++ +LL GA+
Sbjct: 1129 ACSGGRQEVVDLLLARGANKE------HRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1182
Query: 253 IGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL-------AQPEKEKSDILSLEEIL 305
T + GIS AA +GH + LL AQ E ++ L+L
Sbjct: 1183 SRTGSKLGIS--------PLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQ 1234
Query: 306 AEGTDLAETAPPPLCASRNSKAKLRALREAMYHSAEHGYVDV 347
++ +K L L EA A GY +V
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEA----ASGGYAEV 1272
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/177 (26%), Positives = 78/177 (44%), Gaps = 37/177 (20%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLL---------------------DAGADLNVEVV 172
+N +E+G + L AC G + Q+LL +G L++ +
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290
Query: 173 STPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLA 232
H TALT+A G + +V++LL+ GA +E E+G TPL A
Sbjct: 291 LLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG-----HTPLMEA 345
Query: 233 AAVGNFELVSLLLERGADPLIGTMYRNGIST-TPQGDMNSFSQAAAHGHRNVFRKLL 288
A+ G+ E+ +LL+ GA GI+T + + ++ + A GH ++ R LL
Sbjct: 346 ASAGHVEVARVLLDHGA----------GINTHSNEFKESALTLACYKGHLDMVRFLL 392
Score = 47.8 bits (112), Expect = 3e-05
Identities = 46/154 (29%), Positives = 65/154 (42%), Gaps = 29/154 (18%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G TD+ V L + SE G TPLM A G VQ L+ GA++N + H
Sbjct: 579 GHTDVAD--VLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH 636
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
T ++ A GH+ VV+LLL GA ++ G T L AA G
Sbjct: 637 ------------TVVSLACAGGHLAVVELLLAHGADPTHRLKDG-----STMLIEAAKGG 679
Query: 237 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMN 270
+ +VS LL+ Y N + + P D++
Sbjct: 680 HTNVVSYLLD----------YPNNVLSVPTTDVS 703
Score = 35.8 bits (81), Expect = 0.12
Identities = 34/106 (32%), Positives = 45/106 (42%), Gaps = 17/106 (16%)
Query: 145 LMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQ 204
L AC GD V+ LLD G +N H E + L A G+ + Q
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNE------------HTEEGE-SLLCLACSAGYYELAQ 255
Query: 205 LLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGAD 250
+LL A VE G+ TPL A++ G ++V LLL AD
Sbjct: 256 VLLAMHANVEDRGNKGDI----TPLMAASSGGYLDIVKLLLLHDAD 297
Score = 34.7 bits (78), Expect = 0.28
Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 14/99 (14%)
Query: 190 ALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGA 249
+L A G + V+ LLD G V EH EE E+ L LA + G +EL +LL
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVN---EHTEE--GESLLCLACSAGYYELAQVLL---- 258
Query: 250 DPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
M+ N +GD+ A++ G+ ++ + LL
Sbjct: 259 -----AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
Score = 34.7 bits (78), Expect = 0.28
Identities = 24/74 (32%), Positives = 36/74 (48%), Gaps = 13/74 (17%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
I+ +++G TPL A G +VQ+L+ AGAD++ + R T L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA-------------ADNRKITPLMS 1364
Query: 194 AVLHGHIPVVQLLL 207
A GH+ VVQ L+
Sbjct: 1365 AFRKGHVKVVQYLV 1378
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 72.0 bits (175), Expect = 2e-12
Identities = 57/159 (35%), Positives = 77/159 (48%), Gaps = 29/159 (18%)
Query: 133 GINTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 191
GINT S + + L AC +G MV+ LL+AGAD HK +H TAL
Sbjct: 363 GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE-------HKTDEMH------TAL 409
Query: 192 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 251
A + GH+ V +LLLD+GA+V + E+PL LAA G+ EL +LL+ERGA+
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADS-----FESPLTLAACGGHVELAALLIERGAN- 463
Query: 252 LIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 290
+ +AA GH + LLAQ
Sbjct: 464 ---------LEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Score = 66.6 bits (161), Expect = 7e-11
Identities = 47/134 (35%), Positives = 68/134 (50%), Gaps = 17/134 (12%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G +++K ++ T S+ G++PLM A + G V++LLD G+D+N ++
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQI----- 1220
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
ET TALT A G VV LLLD A VE + G TPL AA+ G
Sbjct: 1221 -------ETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTG-----LTPLMEAASGG 1268
Query: 237 NFELVSLLLERGAD 250
E+ +LL++GAD
Sbjct: 1269 YAEVGRVLLDKGAD 1282
Score = 63.5 bits (153), Expect = 6e-10
Identities = 49/146 (33%), Positives = 69/146 (47%), Gaps = 27/146 (18%)
Query: 143 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 202
T L AC G E +V +L+ A + H + + +T L A GH+ V
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIE-------------HRDKKGFTPLILAATAGHVGV 1103
Query: 203 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 262
V++LLD G G +E E +TPL LA + G E+V LLL RGA+ +RN
Sbjct: 1104 VEILLDKG----GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGAN----KEHRNVSD 1155
Query: 263 TTPQGDMNSFSQAAAHGHRNVFRKLL 288
TP S AA+ G+ N+ + LL
Sbjct: 1156 YTP------LSLAASGGYVNIIKILL 1175
Score = 62.4 bits (150), Expect = 1e-09
Identities = 60/198 (30%), Positives = 87/198 (43%), Gaps = 27/198 (13%)
Query: 138 SEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLH 197
++ G+TPLM A G + ++LLD GAD+N V P +R TALT A
Sbjct: 1254 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV----------PSSRD-TALTIAADK 1302
Query: 198 GHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMY 257
GH +LL+ GA ++ + G TPL LA+ G+F++V LL++ GAD
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKG-----NTPLWLASNGGHFDVVQLLVQAGAD------- 1350
Query: 258 RNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPP 317
+ + A GH V + L+ + + SDI + I A TD
Sbjct: 1351 ---VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYI-ATITDKELLKKC 1406
Query: 318 PLCASRNSKAKLRALREA 335
C KAK + EA
Sbjct: 1407 HQCVETIVKAKDQQAAEA 1424
Score = 61.2 bits (147), Expect = 3e-09
Identities = 49/134 (36%), Positives = 67/134 (50%), Gaps = 19/134 (14%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G D+VK + LL +N+ S G T L YAC G +V++LL+ GA++
Sbjct: 283 GYLDIVK--LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI--------- 331
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
H E H T L A GH+ V ++LLD GA G H E + E+ L LA G
Sbjct: 332 ---EDHNENGH-TPLMEAASAGHVEVARVLLDHGA---GINTHSNE-FKESALTLACYKG 383
Query: 237 NFELVSLLLERGAD 250
+ ++V LLE GAD
Sbjct: 384 HLDMVRFLLEAGAD 397
Score = 60.8 bits (146), Expect = 4e-09
Identities = 51/155 (32%), Positives = 69/155 (44%), Gaps = 30/155 (19%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
+ ++++G TPLM A G E MV +LL GA++N + T TALT
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE------------TALTL 511
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 253
A G V L+ AGA +E TPL A+ G+ ELV LL GA
Sbjct: 512 ACCGGFSEVADFLIKAGADIELG--------CSTPLMEASQEGHLELVKYLLASGA---- 559
Query: 254 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
N +TT GD + + A +GH +V LL
Sbjct: 560 -----NVHATTATGD-TALTYACENGHTDVADVLL 588
Score = 57.8 bits (138), Expect = 3e-08
Identities = 63/188 (33%), Positives = 80/188 (42%), Gaps = 36/188 (19%)
Query: 123 KQAVSLLGPDG--INTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH--- 176
++ V+LL G IN +E+ T L AC G + L+ AGAD+ + STP
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC-STPLMEA 542
Query: 177 ---------KY-----PSVHPETRHW-TALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGE 221
KY +VH T TALT+A +GH V +LL AGA +E E G
Sbjct: 543 SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG- 601
Query: 222 ENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHR 281
TPL AA G+ V L+ +GA N T D S A A GH
Sbjct: 602 ----RTPLMKAARAGHLCTVQFLISKGA---------NVNRATANNDHTVVSLACAGGHL 648
Query: 282 NVFRKLLA 289
V LLA
Sbjct: 649 AVVELLLA 656
Score = 53.9 bits (128), Expect = 4e-07
Identities = 63/222 (28%), Positives = 88/222 (39%), Gaps = 38/222 (17%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
I ++G TPL+ A G +V++LLD G D+ + T T L+
Sbjct: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKD------------TPLSL 1128
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSE-TPLQLAAAVGNFELVSLLLERGADPL 252
A G VV LLL GA E N S+ TPL LAA+ G ++ +LL GA+
Sbjct: 1129 ACSGGRQEVVDLLLARGANKE------HRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1182
Query: 253 IGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL-------AQPEKEKSDILSLEEIL 305
T + GIS AA +GH + LL AQ E ++ L+L
Sbjct: 1183 SRTGSKLGIS--------PLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQ 1234
Query: 306 AEGTDLAETAPPPLCASRNSKAKLRALREAMYHSAEHGYVDV 347
++ +K L L EA A GY +V
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEA----ASGGYAEV 1272
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/177 (26%), Positives = 78/177 (44%), Gaps = 37/177 (20%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLL---------------------DAGADLNVEVV 172
+N +E+G + L AC G + Q+LL +G L++ +
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290
Query: 173 STPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLA 232
H TALT+A G + +V++LL+ GA +E E+G TPL A
Sbjct: 291 LLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG-----HTPLMEA 345
Query: 233 AAVGNFELVSLLLERGADPLIGTMYRNGIST-TPQGDMNSFSQAAAHGHRNVFRKLL 288
A+ G+ E+ +LL+ GA GI+T + + ++ + A GH ++ R LL
Sbjct: 346 ASAGHVEVARVLLDHGA----------GINTHSNEFKESALTLACYKGHLDMVRFLL 392
Score = 47.8 bits (112), Expect = 3e-05
Identities = 46/154 (29%), Positives = 65/154 (42%), Gaps = 29/154 (18%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G TD+ V L + SE G TPLM A G VQ L+ GA++N + H
Sbjct: 579 GHTDVAD--VLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH 636
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
T ++ A GH+ VV+LLL GA ++ G T L AA G
Sbjct: 637 ------------TVVSLACAGGHLAVVELLLAHGADPTHRLKDG-----STMLIEAAKGG 679
Query: 237 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMN 270
+ +VS LL+ Y N + + P D++
Sbjct: 680 HTNVVSYLLD----------YPNNVLSVPTTDVS 703
Score = 35.8 bits (81), Expect = 0.12
Identities = 34/106 (32%), Positives = 45/106 (42%), Gaps = 17/106 (16%)
Query: 145 LMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQ 204
L AC GD V+ LLD G +N H E + L A G+ + Q
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNE------------HTEEGE-SLLCLACSAGYYELAQ 255
Query: 205 LLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGAD 250
+LL A VE G+ TPL A++ G ++V LLL AD
Sbjct: 256 VLLAMHANVEDRGNKGDI----TPLMAASSGGYLDIVKLLLLHDAD 297
Score = 34.7 bits (78), Expect = 0.28
Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 14/99 (14%)
Query: 190 ALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGA 249
+L A G + V+ LLD G V EH EE E+ L LA + G +EL +LL
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVN---EHTEE--GESLLCLACSAGYYELAQVLL---- 258
Query: 250 DPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
M+ N +GD+ A++ G+ ++ + LL
Sbjct: 259 -----AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
Score = 34.7 bits (78), Expect = 0.28
Identities = 24/74 (32%), Positives = 36/74 (48%), Gaps = 13/74 (17%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
I+ +++G TPL A G +VQ+L+ AGAD++ + R T L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA-------------ADNRKITPLMS 1364
Query: 194 AVLHGHIPVVQLLL 207
A GH+ VVQ L+
Sbjct: 1365 AFRKGHVKVVQYLV 1378
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 70.5 bits (171), Expect = 5e-12
Identities = 56/159 (35%), Positives = 75/159 (47%), Gaps = 29/159 (18%)
Query: 133 GINTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 191
GINT S + + L AC +G MV+ LL+AGAD HK +H TAL
Sbjct: 392 GINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQE-------HKTDEMH------TAL 438
Query: 192 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 251
A + GH+ V +LLLD+GA+V + E+PL LAA G+ EL +LL+ERGA
Sbjct: 439 MEACMDGHVEVARLLLDSGAQVNMPADS-----FESPLTLAACGGHVELAALLIERGA-- 491
Query: 252 LIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 290
+ +AA GH + LL Q
Sbjct: 492 --------SLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Score = 70.1 bits (170), Expect = 6e-12
Identities = 52/146 (35%), Positives = 71/146 (48%), Gaps = 27/146 (18%)
Query: 143 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 202
T L AC G E +VQ LL+ GA + H + + +T L A GH+ V
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIE-------------HRDKKGFTPLILAATAGHVGV 1131
Query: 203 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 262
V++LLD GA +E E +TPL LA + G E+V LLL RGA+ +RN
Sbjct: 1132 VEILLDNGADIEAQ----SERTKDTPLSLACSGGRQEVVELLLARGAN----KEHRNVSD 1183
Query: 263 TTPQGDMNSFSQAAAHGHRNVFRKLL 288
TP S AA+ G+ N+ + LL
Sbjct: 1184 YTP------LSLAASGGYVNIIKILL 1203
Score = 68.9 bits (167), Expect = 1e-11
Identities = 48/134 (35%), Positives = 69/134 (51%), Gaps = 17/134 (12%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G +++K ++ T S+ G++PLM A + G A V++LLD G+D+N ++
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI----- 1248
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
ET TALT A G VV LLLD A VE + G TPL AA+ G
Sbjct: 1249 -------ETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG-----LTPLMEAASGG 1296
Query: 237 NFELVSLLLERGAD 250
E+ +LL++GAD
Sbjct: 1297 YAEVGRVLLDKGAD 1310
Score = 64.3 bits (155), Expect = 3e-10
Identities = 66/219 (30%), Positives = 96/219 (43%), Gaps = 29/219 (13%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
GRT++V ++ L + ++ G+TPLM A G + ++LLD GAD+N V
Sbjct: 1263 GRTEVV--SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV---- 1316
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
P +R TALT A GH +LL+ GA ++ + G TPL LAA G
Sbjct: 1317 ------PSSRD-TALTIAADKGHYKFCELLIGRGAHIDVRNKKG-----NTPLWLAANGG 1364
Query: 237 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKS 296
+ ++V LL++ GAD + + A GH V R L+ + + S
Sbjct: 1365 HLDVVQLLVQAGAD----------VDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS 1414
Query: 297 DILSLEEILAEGTDLAETAPPPLCASRNSKAKLRALREA 335
D + I A TD LC +AK R EA
Sbjct: 1415 DSECMRYI-ATITDKEMLKKCHLCMESIVQAKDRQAAEA 1452
Score = 63.9 bits (154), Expect = 4e-10
Identities = 52/155 (33%), Positives = 70/155 (45%), Gaps = 30/155 (19%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
+ ++++G TPLM A G E MV +LL GA++N + T TALT
Sbjct: 493 LEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQE------------TALTL 540
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 253
A G + V L+ AGA +E TPL AA G+ ELV LL GA
Sbjct: 541 ACCGGFLEVADFLIKAGADIELG--------CSTPLMEAAQEGHLELVKYLLAAGA---- 588
Query: 254 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
N +TT GD + + A +GH +V LL
Sbjct: 589 -----NVHATTATGD-TALTYACENGHTDVADVLL 617
Score = 61.6 bits (148), Expect = 2e-09
Identities = 63/216 (29%), Positives = 87/216 (40%), Gaps = 38/216 (17%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G +LVK L ++ + G T L YAC G + +LL AGADL
Sbjct: 575 GHLELVKYL--LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE-------- 624
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
H T L A GH+ VQ L+ GA V + N T L LA A G
Sbjct: 625 -----HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT----ANNDHTVLSLACAGG 675
Query: 237 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKS 296
+ +V LLL GADP + + +AA GH +V LL P +
Sbjct: 676 HLAVVELLLAHGADP----------THRLKDGSTMLIEAAKGGHTSVVCYLLDYP----N 721
Query: 297 DILSLEEILAEGTDLAETAPPPLCASRNSKAKLRAL 332
++LS A D+ + PP +R + ++AL
Sbjct: 722 NLLS-----APPPDVTQLTPPSHDLNRAPRVPVQAL 752
Score = 60.1 bits (144), Expect = 6e-09
Identities = 51/147 (34%), Positives = 64/147 (43%), Gaps = 27/147 (18%)
Query: 143 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 202
TPLM A G +V+ LL AGA+++ + TALT+A +GH V
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGD-------------TALTYACENGHTDV 612
Query: 203 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 262
+LL AGA +E E G TPL AA G+ V L+ +GA N
Sbjct: 613 ADVLLQAGADLEHESEGG-----RTPLMKAARAGHVCTVQFLISKGA---------NVNR 658
Query: 263 TTPQGDMNSFSQAAAHGHRNVFRKLLA 289
TT D S A A GH V LLA
Sbjct: 659 TTANNDHTVLSLACAGGHLAVVELLLA 685
Score = 59.3 bits (142), Expect = 1e-08
Identities = 49/136 (36%), Positives = 65/136 (47%), Gaps = 19/136 (13%)
Query: 115 NCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVST 174
N G +VK + L +N S G T L YAC G +V++LL++GA +
Sbjct: 310 NGGHVKIVK--LLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI------- 360
Query: 175 PHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAA 234
H E H T L A GH+ V +LLL+ GA G H E + E+ L LA
Sbjct: 361 -----EDHNENGH-TPLMEAGSAGHVEVARLLLENGA---GINTHSNE-FKESALTLACY 410
Query: 235 VGNFELVSLLLERGAD 250
G+ E+V LLE GAD
Sbjct: 411 KGHLEMVRFLLEAGAD 426
Score = 58.5 bits (140), Expect = 2e-08
Identities = 50/148 (33%), Positives = 76/148 (51%), Gaps = 29/148 (19%)
Query: 142 MTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIP 201
+TPLM A G +V++LL AD+N + ST + TALT+A G++
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQS-STGN------------TALTYACAGGYVD 348
Query: 202 VVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGI 261
VV++LL++GA +E E+G TPL A + G+ E+ LLLE GA GI
Sbjct: 349 VVKVLLESGASIEDHNENG-----HTPLMEAGSAGHVEVARLLLENGA----------GI 393
Query: 262 ST-TPQGDMNSFSQAAAHGHRNVFRKLL 288
+T + + ++ + A GH + R LL
Sbjct: 394 NTHSNEFKESALTLACYKGHLEMVRFLL 421
Score = 56.2 bits (134), Expect = 9e-08
Identities = 47/143 (32%), Positives = 65/143 (45%), Gaps = 19/143 (13%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
I ++G TPL+ A G +V++LLD GAD+ + T T L+
Sbjct: 1109 IEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD------------TPLSL 1156
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSE-TPLQLAAAVGNFELVSLLLERGADPL 252
A G VV+LLL GA E N S+ TPL LAA+ G ++ +LL GA+
Sbjct: 1157 ACSGGRQEVVELLLARGANKE------HRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1210
Query: 253 IGTMYRNGISTTPQGDMNSFSQA 275
T + GIS MN + A
Sbjct: 1211 SRTGSKLGISPLMLAAMNGHTAA 1233
Score = 51.2 bits (121), Expect = 3e-06
Identities = 33/77 (42%), Positives = 45/77 (58%), Gaps = 9/77 (11%)
Query: 178 YPSV----HPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAA 233
YP++ E+ H TALT A GH +VQ LL+ GA S+EH ++ TPL LAA
Sbjct: 1070 YPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGA----SIEHRDKK-GFTPLILAA 1124
Query: 234 AVGNFELVSLLLERGAD 250
G+ +V +LL+ GAD
Sbjct: 1125 TAGHVGVVEILLDNGAD 1141
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 70.5 bits (171), Expect = 5e-12
Identities = 56/159 (35%), Positives = 75/159 (47%), Gaps = 29/159 (18%)
Query: 133 GINTMSEQGM-TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 191
GINT S + + L AC +G MV+ LL+AGAD HK +H TAL
Sbjct: 392 GINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQE-------HKTDEMH------TAL 438
Query: 192 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 251
A + GH+ V +LLLD+GA+V + E+PL LAA G+ EL +LL+ERGA
Sbjct: 439 MEACMDGHVEVARLLLDSGAQVNMPADS-----FESPLTLAACGGHVELAALLIERGA-- 491
Query: 252 LIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 290
+ +AA GH + LL Q
Sbjct: 492 --------SLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Score = 70.1 bits (170), Expect = 6e-12
Identities = 52/146 (35%), Positives = 71/146 (48%), Gaps = 27/146 (18%)
Query: 143 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 202
T L AC G E +VQ LL+ GA + H + + +T L A GH+ V
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIE-------------HRDKKGFTPLILAATAGHVGV 880
Query: 203 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 262
V++LLD GA +E E +TPL LA + G E+V LLL RGA+ +RN
Sbjct: 881 VEILLDNGADIEAQ----SERTKDTPLSLACSGGRQEVVELLLARGAN----KEHRNVSD 932
Query: 263 TTPQGDMNSFSQAAAHGHRNVFRKLL 288
TP S AA+ G+ N+ + LL
Sbjct: 933 YTP------LSLAASGGYVNIIKILL 952
Score = 68.9 bits (167), Expect = 1e-11
Identities = 48/134 (35%), Positives = 69/134 (51%), Gaps = 17/134 (12%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G +++K ++ T S+ G++PLM A + G A V++LLD G+D+N ++
Sbjct: 943 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI----- 997
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
ET TALT A G VV LLLD A VE + G TPL AA+ G
Sbjct: 998 -------ETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG-----LTPLMEAASGG 1045
Query: 237 NFELVSLLLERGAD 250
E+ +LL++GAD
Sbjct: 1046 YAEVGRVLLDKGAD 1059
Score = 64.3 bits (155), Expect = 3e-10
Identities = 66/219 (30%), Positives = 96/219 (43%), Gaps = 29/219 (13%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
GRT++V ++ L + ++ G+TPLM A G + ++LLD GAD+N V
Sbjct: 1012 GRTEVV--SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV---- 1065
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
P +R TALT A GH +LL+ GA ++ + G TPL LAA G
Sbjct: 1066 ------PSSRD-TALTIAADKGHYKFCELLIGRGAHIDVRNKKG-----NTPLWLAANGG 1113
Query: 237 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKS 296
+ ++V LL++ GAD + + A GH V R L+ + + S
Sbjct: 1114 HLDVVQLLVQAGAD----------VDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS 1163
Query: 297 DILSLEEILAEGTDLAETAPPPLCASRNSKAKLRALREA 335
D + I A TD LC +AK R EA
Sbjct: 1164 DSECMRYI-ATITDKEMLKKCHLCMESIVQAKDRQAAEA 1201
Score = 63.9 bits (154), Expect = 4e-10
Identities = 52/155 (33%), Positives = 70/155 (45%), Gaps = 30/155 (19%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
+ ++++G TPLM A G E MV +LL GA++N + T TALT
Sbjct: 493 LEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQE------------TALTL 540
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 253
A G + V L+ AGA +E TPL AA G+ ELV LL GA
Sbjct: 541 ACCGGFLEVADFLIKAGADIELG--------CSTPLMEAAQEGHLELVKYLLAAGA---- 588
Query: 254 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
N +TT GD + + A +GH +V LL
Sbjct: 589 -----NVHATTATGD-TALTYACENGHTDVADVLL 617
Score = 61.6 bits (148), Expect = 2e-09
Identities = 63/216 (29%), Positives = 87/216 (40%), Gaps = 38/216 (17%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G +LVK L ++ + G T L YAC G + +LL AGADL
Sbjct: 575 GHLELVKYL--LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE-------- 624
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
H T L A GH+ VQ L+ GA V + N T L LA A G
Sbjct: 625 -----HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT----ANNDHTVLSLACAGG 675
Query: 237 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKS 296
+ +V LLL GADP + + +AA GH +V LL P +
Sbjct: 676 HLAVVELLLAHGADP----------THRLKDGSTMLIEAAKGGHTSVVCYLLDYP----N 721
Query: 297 DILSLEEILAEGTDLAETAPPPLCASRNSKAKLRAL 332
++LS A D+ + PP +R + ++AL
Sbjct: 722 NLLS-----APPPDVTQLTPPSHDLNRAPRVPVQAL 752
Score = 60.1 bits (144), Expect = 6e-09
Identities = 51/147 (34%), Positives = 64/147 (43%), Gaps = 27/147 (18%)
Query: 143 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 202
TPLM A G +V+ LL AGA+++ + TALT+A +GH V
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGD-------------TALTYACENGHTDV 612
Query: 203 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 262
+LL AGA +E E G TPL AA G+ V L+ +GA N
Sbjct: 613 ADVLLQAGADLEHESEGG-----RTPLMKAARAGHVCTVQFLISKGA---------NVNR 658
Query: 263 TTPQGDMNSFSQAAAHGHRNVFRKLLA 289
TT D S A A GH V LLA
Sbjct: 659 TTANNDHTVLSLACAGGHLAVVELLLA 685
Score = 59.3 bits (142), Expect = 1e-08
Identities = 49/136 (36%), Positives = 65/136 (47%), Gaps = 19/136 (13%)
Query: 115 NCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVST 174
N G +VK + L +N S G T L YAC G +V++LL++GA +
Sbjct: 310 NGGHVKIVK--LLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI------- 360
Query: 175 PHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAA 234
H E H T L A GH+ V +LLL+ GA G H E + E+ L LA
Sbjct: 361 -----EDHNENGH-TPLMEAGSAGHVEVARLLLENGA---GINTHSNE-FKESALTLACY 410
Query: 235 VGNFELVSLLLERGAD 250
G+ E+V LLE GAD
Sbjct: 411 KGHLEMVRFLLEAGAD 426
Score = 58.5 bits (140), Expect = 2e-08
Identities = 50/148 (33%), Positives = 76/148 (51%), Gaps = 29/148 (19%)
Query: 142 MTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIP 201
+TPLM A G +V++LL AD+N + ST + TALT+A G++
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQS-STGN------------TALTYACAGGYVD 348
Query: 202 VVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGI 261
VV++LL++GA +E E+G TPL A + G+ E+ LLLE GA GI
Sbjct: 349 VVKVLLESGASIEDHNENG-----HTPLMEAGSAGHVEVARLLLENGA----------GI 393
Query: 262 ST-TPQGDMNSFSQAAAHGHRNVFRKLL 288
+T + + ++ + A GH + R LL
Sbjct: 394 NTHSNEFKESALTLACYKGHLEMVRFLL 421
Score = 56.2 bits (134), Expect = 9e-08
Identities = 47/143 (32%), Positives = 65/143 (45%), Gaps = 19/143 (13%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
I ++G TPL+ A G +V++LLD GAD+ + T T L+
Sbjct: 858 IEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD------------TPLSL 905
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSE-TPLQLAAAVGNFELVSLLLERGADPL 252
A G VV+LLL GA E N S+ TPL LAA+ G ++ +LL GA+
Sbjct: 906 ACSGGRQEVVELLLARGANKE------HRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 959
Query: 253 IGTMYRNGISTTPQGDMNSFSQA 275
T + GIS MN + A
Sbjct: 960 SRTGSKLGISPLMLAAMNGHTAA 982
Score = 51.2 bits (121), Expect = 3e-06
Identities = 33/77 (42%), Positives = 45/77 (58%), Gaps = 9/77 (11%)
Query: 178 YPSV----HPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAA 233
YP++ E+ H TALT A GH +VQ LL+ GA S+EH ++ TPL LAA
Sbjct: 819 YPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGA----SIEHRDKK-GFTPLILAA 873
Query: 234 AVGNFELVSLLLERGAD 250
G+ +V +LL+ GAD
Sbjct: 874 TAGHVGVVEILLDNGAD 890
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 68.9 bits (167), Expect = 1e-11
Identities = 38/152 (25%), Positives = 78/152 (51%), Gaps = 6/152 (3%)
Query: 455 NNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDGTCIEIGYVKYSIFQLVM 514
+N + +D+ FLV+G+ YAHKVLL F+ SS N+ +E+ Y +++ +
Sbjct: 389 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFR---SSLEDNEDDIVEMSEFSYPVYRAFL 445
Query: 515 QYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIYNHAKFL 574
+YLY +S+ + E + LL A F++ L++ C+ + I +N + + + A
Sbjct: 446 EYLY---TDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKY 502
Query: 575 GVTELSAYCEGYFLKNMMVLIENEAFKQLLYD 606
+L +C + + ++ V+ + F ++ +D
Sbjct: 503 DAQDLEEFCFRFCINHLTVVTQTSGFAEMDHD 534
>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 623
Score = 67.8 bits (164), Expect = 3e-11
Identities = 41/155 (26%), Positives = 73/155 (47%), Gaps = 4/155 (2%)
Query: 453 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKAL-LSSKPTNDGTCIEIGYVKYSIFQ 511
F + +D+ +VEG F HK++L T S F+A+ +S + T + + V + Q
Sbjct: 24 FYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQ 83
Query: 512 LVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIYNHA 571
+++ Y Y G +L + ++ + +L A F Q+E + + C K IN +NCV + + A
Sbjct: 84 IIITYAYTG---NLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFA 140
Query: 572 KFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYD 606
EL + + +AF QL +D
Sbjct: 141 DLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHD 175
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 64.7 bits (156), Expect = 3e-10
Identities = 44/191 (23%), Positives = 83/191 (43%), Gaps = 4/191 (2%)
Query: 428 HCYGPYPIPKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKA 487
H Y + LT + +Q + + E+ D+ V +AHKV+L + SP FKA
Sbjct: 3 HTSPTYMLANLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKA 62
Query: 488 LLSSKPTN-DGTCIEIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEA 546
+ + + + + +E + + Q +++Y Y G ++ I + + LL AA Q++
Sbjct: 63 MFTGNLSEKENSEVEFQCIDETALQAIVEYAYTG---TVFISQDTVESLLPAANLLQIKL 119
Query: 547 LQRHCEIICAKSINTDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYD 606
+ + C ++ NC+ I A+ G +L Y +N + + E F +L +
Sbjct: 120 VLKECCAFLESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHA 179
Query: 607 KNGEGTGQDVL 617
E D L
Sbjct: 180 DLDEIVSNDCL 190
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 62.8 bits (151), Expect = 1e-09
Identities = 52/160 (32%), Positives = 72/160 (45%), Gaps = 33/160 (20%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
+N +G T L+ A G +V+ LLD GA++N H + TAL+
Sbjct: 670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVN-------------HEDVDGRTALSV 716
Query: 194 AVL-----HGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERG 248
A L GH VV LL+D GA+V+ + G TPL +AA G+ ++V LLLE G
Sbjct: 717 AALCVPASKGHASVVSLLIDRGAEVDHCDKDG-----MTPLLVAAYEGHVDVVDLLLEGG 771
Query: 249 ADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
AD + T AA+ GH +V LL
Sbjct: 772 AD----------VDHTDNNGRTPLLAAASMGHASVVNTLL 801
Score = 62.4 bits (150), Expect = 1e-09
Identities = 55/167 (32%), Positives = 74/167 (44%), Gaps = 30/167 (17%)
Query: 126 VSLLGPDG--INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHP 183
VSLL G ++ + GMTPL+ A G +V +LL+ GAD++ H
Sbjct: 731 VSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-------------HT 777
Query: 184 ETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSL 243
+ T L A GH VV LL GA V+ G T L +A+A GN E+V
Sbjct: 778 DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG-----RTVLSIASAQGNVEVVRT 832
Query: 244 LLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 290
LL+RG D +R+ TP AA GHR + L+ Q
Sbjct: 833 LLDRGLD----ENHRDDAGWTP------LHMAAFEGHRLICEALIEQ 869
Score = 59.3 bits (142), Expect = 1e-08
Identities = 45/154 (29%), Positives = 69/154 (44%), Gaps = 28/154 (18%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
+ +G T L +C +G MVQ+L+ AD+N + +AL
Sbjct: 972 VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAA-------------DNEKRSALQS 1018
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 253
A GH+ VVQLL++ GA V+ + G T L +AA G+ ++V +LLE GADP
Sbjct: 1019 AAWQGHVKVVQLLIEHGAVVDHTCNQGA-----TALCIAAQEGHIDVVQVLLEHGADP-- 1071
Query: 254 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKL 287
+ Q + AA +GH + + L
Sbjct: 1072 --------NHADQFGRTAMRVAAKNGHSQIIKLL 1097
Score = 54.3 bits (129), Expect = 3e-07
Identities = 52/172 (30%), Positives = 73/172 (42%), Gaps = 30/172 (17%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G D+V VS G D + G TPL A +G +V L+ GA++N
Sbjct: 556 GSLDVVNLLVSR-GAD-LEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN-------- 605
Query: 177 KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVG 236
H + WTAL A GH VV LL AG KV+ + + S T L+ AA G
Sbjct: 606 -----HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCA-----DADSRTALRAAAWGG 655
Query: 237 NFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
+ ++V LL+ GA+ ++ + AA GHR + LL
Sbjct: 656 HEDIVLNLLQHGAE----------VNKADNEGRTALIAAAYMGHREIVEHLL 697
Score = 53.9 bits (128), Expect = 4e-07
Identities = 46/184 (25%), Positives = 75/184 (40%), Gaps = 37/184 (20%)
Query: 115 NCGRTDLVKQA---------VSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGA 165
N GRT L+ A L ++++ +G T L A +G+ +V+ LLD G
Sbjct: 779 NNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL 838
Query: 166 DLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYS 225
D N H + WT L A GH + + L++ GA+ + +N
Sbjct: 839 DEN-------------HRDDAGWTPLHMAAFEGHRLICEALIEQGART-----NEIDNDG 880
Query: 226 ETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFR 285
P LA+ G+++ V +LLE ++ I N+ AA GHR++
Sbjct: 881 RIPFILASQEGHYDCVQILLEN----------KSNIDQRGYDGRNALRVAALEGHRDIVE 930
Query: 286 KLLA 289
L +
Sbjct: 931 LLFS 934
Score = 45.8 bits (107), Expect = 1e-04
Identities = 44/146 (30%), Positives = 61/146 (41%), Gaps = 23/146 (15%)
Query: 143 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 202
T L A G E +V LL GA++N + TAL A GH +
Sbjct: 646 TALRAAAWGGHEDIVLNLLQHGAEVN-------------KADNEGRTALIAAAYMGHREI 692
Query: 203 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGIS 262
V+ LLD GA+V G S L + A+ G+ +VSLL++RGA+ +
Sbjct: 693 VEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE----------VD 742
Query: 263 TTPQGDMNSFSQAAAHGHRNVFRKLL 288
+ M AA GH +V LL
Sbjct: 743 HCDKDGMTPLLVAAYEGHVDVVDLLL 768
Score = 35.0 bits (79), Expect = 0.21
Identities = 39/154 (25%), Positives = 60/154 (38%), Gaps = 29/154 (18%)
Query: 140 QGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGH 199
QG T L A G +VQ+LL+ GAD N H + TA+ A +GH
Sbjct: 1044 QGATALCIAAQEGHIDVVQVLLEHGADPN-------------HADQFGRTAMRVAAKNGH 1090
Query: 200 IPVVQLLLDAGA-KVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYR 258
+++LL GA + G + PLQ ++ ++ SL T+
Sbjct: 1091 SQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSS----KVQSL-----------TIKS 1135
Query: 259 NGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPE 292
N +T GDM + +G + F P+
Sbjct: 1136 NSSGSTGGGDMQPSLRGLPNGPTHAFSSPSESPD 1169
>gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo
sapiens]
Length = 313
Score = 62.4 bits (150), Expect = 1e-09
Identities = 51/150 (34%), Positives = 69/150 (46%), Gaps = 28/150 (18%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
IN E+G TPLM+A G A+V+ LL GAD P + + R +AL+
Sbjct: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD------------PQLLGKGRE-SALSL 221
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 253
A G+ +V++LLD G V +G TPL A + + V +LLE GADP I
Sbjct: 222 ACSKGYTDIVKMLLDCGVDVNEYDWNG-----GTPLLYAVHGNHVKCVKMLLESGADPTI 276
Query: 254 GTMYRNGISTTPQGDMNSFSQAAAHGHRNV 283
T NS A A G+R+V
Sbjct: 277 ET----------DSGYNSMDLAVALGYRSV 296
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 61.6 bits (148), Expect = 2e-09
Identities = 65/255 (25%), Positives = 113/255 (44%), Gaps = 32/255 (12%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
+N + +G TP+ AC G E +V++LL G D++++ W L +
Sbjct: 530 VNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDA-------------WLPLHY 576
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLI 253
A GH+P+V+LL AK G + + TPL LAA G++ + +L++ +D +
Sbjct: 577 AAWQGHLPIVKLL----AKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNV 632
Query: 254 GTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL---AQPEKEKSDILSLEEILAEGTD 310
++ ++ TP AA GH + R LL A E SD + + A
Sbjct: 633 CSL----LAQTP------LHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGH 682
Query: 311 LAETAPPPLCASRNSKAKLRALREAMYHSAEHGYVDVTIDIRSIGVPWTL-HTWLESLRI 369
LA T + + A+ + A++ +A HG+ +V ++ S V L +L +
Sbjct: 683 LA-TVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHL 741
Query: 370 AFQQHRRPLIQCLLK 384
A Q ++ LL+
Sbjct: 742 AAQGRHAQTVETLLR 756
Score = 45.4 bits (106), Expect = 2e-04
Identities = 44/164 (26%), Positives = 63/164 (38%), Gaps = 28/164 (17%)
Query: 128 LLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRH 187
LL N + +G TPL A R +V++LL +N + +
Sbjct: 458 LLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAK-------------DEDQ 504
Query: 188 WTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLER 247
WTAL FA +G +LLL+ A V G TP+ +A G +V +LL R
Sbjct: 505 WTALHFAAQNGDESSTRLLLEKNASVNEVDFEG-----RTPMHVACQHGQENIVRILLRR 559
Query: 248 GADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQP 291
G D +S + AA GH + + L QP
Sbjct: 560 GVD----------VSLQGKDAWLPLHYAAWQGHLPIVKLLAKQP 593
>gi|67906195 ankyrin repeat and sterile alpha motif domain
containing 6 [Homo sapiens]
Length = 871
Score = 61.2 bits (147), Expect = 3e-09
Identities = 57/170 (33%), Positives = 82/170 (48%), Gaps = 23/170 (13%)
Query: 77 VDCEPRQL--RADDCFCASRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGI 134
+DC+ R L D K D E K + D+ F L G LVK+ ++ P +
Sbjct: 266 LDCKHRDLVDYLDPLTTVRPKTD----EEKRRPDI-FHALKMGNFQLVKE-IADEDPSHV 319
Query: 135 NTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFA 194
N ++ G TPLM A V G A+VQ+L++ AD++ K SVH WTAL A
Sbjct: 320 NLVNGDGATPLMLAAVTGQLALVQLLVERHADVD--------KQDSVH----GWTALMQA 367
Query: 195 VLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLL 244
HG+ +V+ LL+ GA V ++G Y+ L + + ELV LL
Sbjct: 368 TYHGNKEIVKYLLNQGADVTLRAKNG---YTAFDLVMLLNDPDTELVRLL 414
Score = 57.8 bits (138), Expect = 3e-08
Identities = 51/162 (31%), Positives = 69/162 (42%), Gaps = 22/162 (13%)
Query: 131 PDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTA 190
P ++ E G T L +A G E +V+ LL GA +N S H W+A
Sbjct: 68 PVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVN----SRNHY---------GWSA 114
Query: 191 LTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGA- 249
L A GH+ V LLLD GA V + + + L +A+ G+ +V LLLE GA
Sbjct: 115 LMQAARFGHVSVAHLLLDHGADV-----NAQNRLGASVLTVASRGGHLGVVKLLLEAGAF 169
Query: 250 ---DPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
G G S D+ + A HGH V R L+
Sbjct: 170 VDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLM 211
Score = 53.1 bits (126), Expect = 8e-07
Identities = 40/126 (31%), Positives = 59/126 (46%), Gaps = 19/126 (15%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPS--------VHPET 185
+N + G + L A G +V++LL+AGA ++ H +PS E
Sbjct: 137 VNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVD-------HHHPSGEQLGLGGSRDEP 189
Query: 186 RHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLL 245
TAL A+ HGH VV+LL++ GA H +PL LAA G + L+
Sbjct: 190 LDITALMAAIQHGHEAVVRLLMEWGA----DPNHAARTVGWSPLMLAALTGRLGVAQQLV 245
Query: 246 ERGADP 251
E+GA+P
Sbjct: 246 EKGANP 251
Score = 45.1 bits (105), Expect = 2e-04
Identities = 50/179 (27%), Positives = 69/179 (38%), Gaps = 42/179 (23%)
Query: 137 MSEQGMTP----LMYACVRGDEAMVQMLLDAGADLNVEVVSTPH---------------- 176
M E G+ P L+ AC +GD + LL+ GA E + P
Sbjct: 1 MGEGGLPPAFQLLLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAA 60
Query: 177 -------KYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPL 229
P + TAL FA GH P+V+ LL GA V + +Y + L
Sbjct: 61 AAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASV-----NSRNHYGWSAL 115
Query: 230 QLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
AA G+ + LLL+ GAD + R G S + A+ GH V + LL
Sbjct: 116 MQAARFGHVSVAHLLLDHGAD--VNAQNRLGASV--------LTVASRGGHLGVVKLLL 164
Score = 37.0 bits (84), Expect = 0.056
Identities = 47/185 (25%), Positives = 77/185 (41%), Gaps = 40/185 (21%)
Query: 130 GPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGAD---LNV---------------EV 171
G D + G +PLM A + G + Q L++ GA+ L+V ++
Sbjct: 214 GADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDL 273
Query: 172 VSTPHKYPSVHPET---RHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETP 228
V +V P+T + + A+ G+ +V+ + D V +G+ TP
Sbjct: 274 VDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLV-NGD---GATP 329
Query: 229 LQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFS---QAAAHGHRNVFR 285
L LAA G LV LL+ER AD Q ++ ++ QA HG++ + +
Sbjct: 330 LMLAAVTGQLALVQLLVERHAD------------VDKQDSVHGWTALMQATYHGNKEIVK 377
Query: 286 KLLAQ 290
LL Q
Sbjct: 378 YLLNQ 382
Score = 33.1 bits (74), Expect = 0.81
Identities = 22/62 (35%), Positives = 32/62 (51%), Gaps = 4/62 (6%)
Query: 189 TALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERG 248
T L A + G + +VQLL++ A V+ + + T L A GN E+V LL +G
Sbjct: 328 TPLMLAAVTGQLALVQLLVERHADVDKQ----DSVHGWTALMQATYHGNKEIVKYLLNQG 383
Query: 249 AD 250
AD
Sbjct: 384 AD 385
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 61.2 bits (147), Expect = 3e-09
Identities = 48/128 (37%), Positives = 61/128 (47%), Gaps = 17/128 (13%)
Query: 135 NTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFA 194
N ++ G T L AC+ G VQ L+ G LN P Y WT L A
Sbjct: 523 NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLN------PRDYCG-------WTPLHEA 569
Query: 195 VLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIG 254
+GH+ +V+ LLD GA V+ G E TPL A G+FE+ LLLERGA +
Sbjct: 570 CNYGHLEIVRFLLDHGAAVDDPGGQGCEGI--TPLHDALNCGHFEVAELLLERGASVTLR 627
Query: 255 TMYRNGIS 262
T R G+S
Sbjct: 628 T--RKGLS 633
Score = 31.6 bits (70), Expect = 2.4
Identities = 33/94 (35%), Positives = 39/94 (41%), Gaps = 16/94 (17%)
Query: 120 DLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYP 179
DLV+Q L N G TPL AC G +V+ LLD GA V P
Sbjct: 547 DLVRQGHPL------NPRDYCGWTPLHEACNYGHLEIVRFLLDHGA-----AVDDPG--- 592
Query: 180 SVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKV 213
T L A+ GH V +LLL+ GA V
Sbjct: 593 --GQGCEGITPLHDALNCGHFEVAELLLERGASV 624
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 61.2 bits (147), Expect = 3e-09
Identities = 46/128 (35%), Positives = 64/128 (50%), Gaps = 20/128 (15%)
Query: 124 QAVSLLGPDG--INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSV 181
Q V LL G +N +QG TPLM A G V LL GA + +
Sbjct: 1081 QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL------------ 1128
Query: 182 HPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELV 241
+ TAL++A L GH+ VV+ L+D GA + +H ++N TPL LAA G+ E+V
Sbjct: 1129 -MDKEGLTALSWACLKGHLSVVRSLVDNGA----ATDHADKN-GRTPLDLAAFYGDAEVV 1182
Query: 242 SLLLERGA 249
L++ GA
Sbjct: 1183 QFLVDHGA 1190
Score = 49.3 bits (116), Expect = 1e-05
Identities = 37/117 (31%), Positives = 56/117 (47%), Gaps = 20/117 (17%)
Query: 134 INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTF 193
I M ++G+T L +AC++G ++V+ L+D GA + H + T L
Sbjct: 1126 IALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD-------------HADKNGRTPLDL 1172
Query: 194 AVLHGHIPVVQLLLDAGAKVEGSVEHGEENYS-ETPLQLAAAVGNFELVSLLLERGA 249
A +G VVQ L+D GA +E +YS PL A N +V LL++GA
Sbjct: 1173 AAFYGDAEVVQFLVDHGAMIE------HVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
Score = 47.4 bits (111), Expect = 4e-05
Identities = 45/148 (30%), Positives = 63/148 (42%), Gaps = 28/148 (18%)
Query: 141 GMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHI 200
G T L A RG + ++LL+ GA + P R L V GH
Sbjct: 1034 GETALTAAAGRGKLEVCRLLLEQGAAV-------------AQPNRRGAVPLFSTVRQGHW 1080
Query: 201 PVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNG 260
+V LLL GA V + + G TPL +AA+ G+ V LL +GA I M + G
Sbjct: 1081 QIVDLLLTHGADVNMADKQG-----RTPLMMAASEGHLGTVDFLLAQGAS--IALMDKEG 1133
Query: 261 ISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
++ + S A GH +V R L+
Sbjct: 1134 LT--------ALSWACLKGHLSVVRSLV 1153
Score = 43.9 bits (102), Expect = 5e-04
Identities = 57/201 (28%), Positives = 76/201 (37%), Gaps = 44/201 (21%)
Query: 117 GRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPH 176
G T++V A+ L ++ SE G+TPL YA G ++V +L A V+ +
Sbjct: 896 GYTEMV--ALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRA--KVDHLDKNG 951
Query: 177 KYPSVHPETR------------HWT-----------------ALTFAVLHGHIPVVQLLL 207
+ VH R WT AL A G+ +V LL
Sbjct: 952 QCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLL 1011
Query: 208 DAGAKVEGSVEHGEEN-----YSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNG-- 260
D K E VE + N + ET L AA G E+ LLLE+GA + R G
Sbjct: 1012 DLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGA--AVAQPNRRGAV 1069
Query: 261 --ISTTPQGDMNSFSQAAAHG 279
ST QG HG
Sbjct: 1070 PLFSTVRQGHWQIVDLLLTHG 1090
Score = 35.0 bits (79), Expect = 0.21
Identities = 30/91 (32%), Positives = 43/91 (47%), Gaps = 15/91 (16%)
Query: 198 GHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMY 257
G+ +V LLL+ GA V+ S E G TPL AAA G +V LL ++ A + +
Sbjct: 896 GYTEMVALLLEFGANVDASSESGL-----TPLGYAAAAGYLSIVVLLCKKRAK--VDHLD 948
Query: 258 RNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
+NG + AA GH V + L+
Sbjct: 949 KNG--------QCALVHAALRGHLEVVKFLI 971
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 60.1 bits (144), Expect = 6e-09
Identities = 34/138 (24%), Positives = 66/138 (47%), Gaps = 4/138 (2%)
Query: 471 FYAHKVLLFTASPRFKALLSS-KPTNDGTCIEIGYVKYSIFQLVMQYLYYGGPESLLIKN 529
F H+V++ +AS FKA+ + D CI++ V + ++ ++Y L +
Sbjct: 105 FPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTA---KLSLNM 161
Query: 530 NEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDIYNHAKFLGVTELSAYCEGYFLK 589
+ + + L AA F Q+ + C++ + DNCV++ A +TE+ Y + LK
Sbjct: 162 DNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLK 221
Query: 590 NMMVLIENEAFKQLLYDK 607
N L+ F +L +++
Sbjct: 222 NFPALLSTGEFLKLPFER 239
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 59.7 bits (143), Expect = 8e-09
Identities = 46/128 (35%), Positives = 65/128 (50%), Gaps = 20/128 (15%)
Query: 124 QAVSLLGPDG--INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSV 181
Q V LL G +N +QG TPLM A G + V+ LL GA L+
Sbjct: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALS------------- 1164
Query: 182 HPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELV 241
+ +AL++A L GH VVQ L++ GA ++ + ++G TPL LAA G+ E V
Sbjct: 1165 SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG-----RTPLDLAAFYGDAETV 1219
Query: 242 SLLLERGA 249
L+E+GA
Sbjct: 1220 LYLVEKGA 1227
Score = 45.4 bits (106), Expect = 2e-04
Identities = 47/165 (28%), Positives = 68/165 (41%), Gaps = 18/165 (10%)
Query: 126 VSLLGPDGINT--MSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHP 183
V LL G+ + ++G L+++ +RG ++Q LL E P + ++
Sbjct: 976 VCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTC------EWSPGPPQPGTLRK 1029
Query: 184 ETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSL 243
ALT A GH VVQ LL + E V + + ET L AA G E+ L
Sbjct: 1030 SHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCEL 1089
Query: 244 LLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
LL GA +S T + + AA GH + R LL
Sbjct: 1090 LLGHGA----------AVSRTNRRGVPPLFCAARQGHWQIVRLLL 1124
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/146 (30%), Positives = 62/146 (42%), Gaps = 23/146 (15%)
Query: 145 LMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQ 204
L A G ++VQ LL + VEV T + TALT A G + V +
Sbjct: 1037 LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGE--------TALTAAAGRGKLEVCE 1088
Query: 205 LLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTT 264
LLL GA V + G PL AA G++++V LLLERG D ++ +
Sbjct: 1089 LLLGHGAAVSRTNRRGVP-----PLFCAARQGHWQIVRLLLERGCD----------VNLS 1133
Query: 265 PQGDMNSFSQAAAHGHRNVFRKLLAQ 290
+ AA GH + LL++
Sbjct: 1134 DKQGRTPLMVAACEGHLSTVEFLLSK 1159
Score = 37.4 bits (85), Expect = 0.043
Identities = 23/51 (45%), Positives = 32/51 (62%), Gaps = 5/51 (9%)
Query: 198 GHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERG 248
GH VV LLL+ GA ++G+ E+G T L AAA G+ +LV LL ++G
Sbjct: 938 GHEEVVTLLLEFGACLDGTSENG-----MTALCYAAAAGHMKLVCLLTKKG 983
Score = 31.6 bits (70), Expect = 2.4
Identities = 43/187 (22%), Positives = 80/187 (42%), Gaps = 33/187 (17%)
Query: 128 LLGPDGINTMSEQ-GMTPLMYACVR---GDEAMVQMLLDAGADLNVEVVSTPHKYPSVHP 183
+LG +N +E P++ CV+ G E +V +LL+ GA L+
Sbjct: 912 ILGGANVNYRTEVLNNAPIL--CVQSHLGHEEVVTLLLEFGACLD-------------GT 956
Query: 184 ETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSL 243
TAL +A GH+ +V LL G +V+ + G + L +A G+ +++
Sbjct: 957 SENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKG-----QCALVHSALRGHGDILQY 1011
Query: 244 LLE---RGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILS 300
LL P GT+ ++ + + AA+ GH +V + LL ++ + ++
Sbjct: 1012 LLTCEWSPGPPQPGTLRKS------HALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNG 1065
Query: 301 LEEILAE 307
+ + E
Sbjct: 1066 TDTLWGE 1072
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 59.7 bits (143), Expect = 8e-09
Identities = 46/128 (35%), Positives = 65/128 (50%), Gaps = 20/128 (15%)
Query: 124 QAVSLLGPDG--INTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSV 181
Q V LL G +N +QG TPLM A G + V+ LL GA L+
Sbjct: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALS------------- 1172
Query: 182 HPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELV 241
+ +AL++A L GH VVQ L++ GA ++ + ++G TPL LAA G+ E V
Sbjct: 1173 SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG-----RTPLDLAAFYGDAETV 1227
Query: 242 SLLLERGA 249
L+E+GA
Sbjct: 1228 LYLVEKGA 1235
Score = 45.4 bits (106), Expect = 2e-04
Identities = 47/165 (28%), Positives = 68/165 (41%), Gaps = 18/165 (10%)
Query: 126 VSLLGPDGINT--MSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHP 183
V LL G+ + ++G L+++ +RG ++Q LL E P + ++
Sbjct: 984 VCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTC------EWSPGPPQPGTLRK 1037
Query: 184 ETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSL 243
ALT A GH VVQ LL + E V + + ET L AA G E+ L
Sbjct: 1038 SHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCEL 1097
Query: 244 LLERGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLL 288
LL GA +S T + + AA GH + R LL
Sbjct: 1098 LLGHGA----------AVSRTNRRGVPPLFCAARQGHWQIVRLLL 1132
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/146 (30%), Positives = 62/146 (42%), Gaps = 23/146 (15%)
Query: 145 LMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQ 204
L A G ++VQ LL + VEV T + TALT A G + V +
Sbjct: 1045 LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGE--------TALTAAAGRGKLEVCE 1096
Query: 205 LLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTT 264
LLL GA V + G PL AA G++++V LLLERG D ++ +
Sbjct: 1097 LLLGHGAAVSRTNRRGVP-----PLFCAARQGHWQIVRLLLERGCD----------VNLS 1141
Query: 265 PQGDMNSFSQAAAHGHRNVFRKLLAQ 290
+ AA GH + LL++
Sbjct: 1142 DKQGRTPLMVAACEGHLSTVEFLLSK 1167
Score = 37.4 bits (85), Expect = 0.043
Identities = 23/51 (45%), Positives = 32/51 (62%), Gaps = 5/51 (9%)
Query: 198 GHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERG 248
GH VV LLL+ GA ++G+ E+G T L AAA G+ +LV LL ++G
Sbjct: 946 GHEEVVTLLLEFGACLDGTSENG-----MTALCYAAAAGHMKLVCLLTKKG 991
Score = 31.6 bits (70), Expect = 2.4
Identities = 43/187 (22%), Positives = 80/187 (42%), Gaps = 33/187 (17%)
Query: 128 LLGPDGINTMSEQ-GMTPLMYACVR---GDEAMVQMLLDAGADLNVEVVSTPHKYPSVHP 183
+LG +N +E P++ CV+ G E +V +LL+ GA L+
Sbjct: 920 ILGGANVNYRTEVLNNAPIL--CVQSHLGHEEVVTLLLEFGACLD-------------GT 964
Query: 184 ETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSL 243
TAL +A GH+ +V LL G +V+ + G + L +A G+ +++
Sbjct: 965 SENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKG-----QCALVHSALRGHGDILQY 1019
Query: 244 LLE---RGADPLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILS 300
LL P GT+ ++ + + AA+ GH +V + LL ++ + ++
Sbjct: 1020 LLTCEWSPGPPQPGTLRKS------HALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNG 1073
Query: 301 LEEILAE 307
+ + E
Sbjct: 1074 TDTLWGE 1080
>gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isoform
a [Homo sapiens]
Length = 534
Score = 59.7 bits (143), Expect = 8e-09
Identities = 32/115 (27%), Positives = 61/115 (53%), Gaps = 4/115 (3%)
Query: 454 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDGTCIEIGYVKYSIFQL 512
L + +DVT VEGR F H+++L S F+++ +S I + V S+FQL
Sbjct: 55 LEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQL 114
Query: 513 VMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDI 567
++ Y+Y+G ++ ++ E+ E+ + +QL +L C A+++ NC+ +
Sbjct: 115 LVDYIYHG---TVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQV 166
>gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isoform
b [Homo sapiens]
Length = 518
Score = 59.7 bits (143), Expect = 8e-09
Identities = 32/115 (27%), Positives = 61/115 (53%), Gaps = 4/115 (3%)
Query: 454 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSK-PTNDGTCIEIGYVKYSIFQL 512
L + +DVT VEGR F H+++L S F+++ +S I + V S+FQL
Sbjct: 39 LEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQL 98
Query: 513 VMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCVDI 567
++ Y+Y+G ++ ++ E+ E+ + +QL +L C A+++ NC+ +
Sbjct: 99 LVDYIYHG---TVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQV 150
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 58.9 bits (141), Expect = 1e-08
Identities = 42/120 (35%), Positives = 63/120 (52%), Gaps = 18/120 (15%)
Query: 132 DGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 191
D +N +E+G T L A +RGD ++ L+ GAD+NV+ + WTAL
Sbjct: 159 DKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVK-------------DFAGWTAL 205
Query: 192 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 251
A G+ V + LL AGA+V G ++ +TPL AA G++++V LLL G +P
Sbjct: 206 HEACNRGYYDVAKQLLAAGAEVN---TKGLDD--DTPLHDAANNGHYKVVKLLLRYGGNP 260
>gi|28461129 ankyrin repeat and MYND domain containing 2 [Homo
sapiens]
Length = 441
Score = 58.9 bits (141), Expect = 1e-08
Identities = 40/125 (32%), Positives = 64/125 (51%), Gaps = 19/125 (15%)
Query: 122 VKQAVSLLGPDGI--NTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYP 179
V++A +LL + N + E GMTPLM+A +G M ++LL GAD+N
Sbjct: 25 VQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVN----------- 73
Query: 180 SVHPETRHWTALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFE 239
H +TAL FA L G+ + ++L+AGA+ + + T Q+AA VG +
Sbjct: 74 -CHQHEHGYTALMFAALSGNKDITWVMLEAGAETD-----VVNSVGRTAAQMAAFVGQHD 127
Query: 240 LVSLL 244
V+++
Sbjct: 128 CVTII 132
Score = 30.0 bits (66), Expect = 6.8
Identities = 23/63 (36%), Positives = 31/63 (49%), Gaps = 6/63 (9%)
Query: 189 TALTFAVLHGHIPVVQLLLDAGAKVE-GSVEHGEENYSETPLQLAAAVGNFELVSLLLER 247
T L A G + + +LLL GA V EHG T L AA GN ++ ++LE
Sbjct: 48 TPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGY-----TALMFAALSGNKDITWVMLEA 102
Query: 248 GAD 250
GA+
Sbjct: 103 GAE 105
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 58.9 bits (141), Expect = 1e-08
Identities = 40/173 (23%), Positives = 78/173 (45%), Gaps = 4/173 (2%)
Query: 432 PYPIPKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSS 491
P +P +++ +QT + ++E+ DV +V + YAH+V+L SP F+A+ +
Sbjct: 40 PARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTG 99
Query: 492 K-PTNDGTCIEIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRH 550
+ + T + I + +L++ + Y + ++ + LL AA QL +Q
Sbjct: 100 ELAESRQTEVVIRDIDERAMELLIDFAY---TSQITVEEGNVQTLLPAACLLQLAEIQEA 156
Query: 551 CEIICAKSINTDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQL 603
C + ++ NC+ I A EL + + N ++E+E F L
Sbjct: 157 CCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLL 209
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 58.5 bits (140), Expect = 2e-08
Identities = 50/160 (31%), Positives = 70/160 (43%), Gaps = 31/160 (19%)
Query: 131 PDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTA 190
PD N E TPL AC R + V++L+ AD N H R WTA
Sbjct: 150 PDISNKSRE---TPLYKACERKNAEAVKILVQHNADTN-------------HRCNRGWTA 193
Query: 191 LTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGAD 250
L +V + V+Q+L+ GAKVE + Y TPL +AA G E + L + GAD
Sbjct: 194 LHESVSRNDLEVMQILVSGGAKVE-----SKNAYGITPLFVAAQSGQLEALRFLAKYGAD 248
Query: 251 PLIGTMYRNGISTTPQGDMNSFSQAAAHGHRNVFRKLLAQ 290
I+T + ++ +A + H V LL+Q
Sbjct: 249 ----------INTQASDNASALYEACKNEHEEVVEFLLSQ 278
Score = 44.7 bits (104), Expect = 3e-04
Identities = 37/151 (24%), Positives = 63/151 (41%), Gaps = 21/151 (13%)
Query: 129 LGPDGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHW 188
L P+ ++ + L +A V + ++LL GAD N +V+S
Sbjct: 351 LAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVIS--------------- 395
Query: 189 TALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERG 248
L A+ HG + +QLLLD GA ++ + + + P + A+ L+ L++ G
Sbjct: 396 -PLLVAIRHGCLRTMQLLLDHGANIDAYI---ATHPTAFPATIMFAMKCLSLLKFLMDLG 451
Query: 249 AD--PLIGTMYRNGISTTPQGDMNSFSQAAA 277
D P +Y NG + F+ A A
Sbjct: 452 CDGEPCFSCLYGNGPHPPAPQPSSRFNDAPA 482
Score = 43.9 bits (102), Expect = 5e-04
Identities = 40/163 (24%), Positives = 66/163 (40%), Gaps = 26/163 (15%)
Query: 91 CASRKLDAVAIEAKFKQDLGFRML--------NCGRTDLVKQAVSLLGPDGINTMSEQGM 142
C + +AV I + D R + R DL + + G + + + G+
Sbjct: 165 CERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGI 224
Query: 143 TPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPV 202
TPL A G ++ L GAD+N + + + +AL A + H V
Sbjct: 225 TPLFVAAQSGQLEALRFLAKYGADINTQA-------------SDNASALYEACKNEHEEV 271
Query: 203 VQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLL 245
V+ LL GA + + G PL +A+ GN+ +V +LL
Sbjct: 272 VEFLLSQGADANKTNKDG-----LLPLHIASKKGNYRIVQMLL 309
Score = 39.7 bits (91), Expect = 0.009
Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 12/110 (10%)
Query: 141 GMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHI 200
G++PL A R + +++ LL A D+N + + E R +AL FAV++ ++
Sbjct: 321 GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL----YEDRRSSALYFAVVNNNV 376
Query: 201 PVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGAD 250
+LLL GA V +PL +A G + LLL+ GA+
Sbjct: 377 YATELLLQHGADPNRDV--------ISPLLVAIRHGCLRTMQLLLDHGAN 418
Score = 32.7 bits (73), Expect = 1.1
Identities = 22/62 (35%), Positives = 30/62 (48%), Gaps = 5/62 (8%)
Query: 189 TALTFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERG 248
TA+ A GH+ + LL AGA+ + S ETPL A N E V +L++
Sbjct: 126 TAVYLATCRGHLDCLLSLLQAGAEPDIS-----NKSRETPLYKACERKNAEAVKILVQHN 180
Query: 249 AD 250
AD
Sbjct: 181 AD 182
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 58.2 bits (139), Expect = 2e-08
Identities = 40/120 (33%), Positives = 63/120 (52%), Gaps = 18/120 (15%)
Query: 132 DGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 191
D +N +E+G TPL A +RGD V+ L+ GA++NV+ + WT L
Sbjct: 153 DKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVK-------------DFAGWTPL 199
Query: 192 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 251
A G+ V ++L+ AGA V G ++ +TPL +A+ G+ ++V LLL G +P
Sbjct: 200 HEACNVGYYDVAKILIAAGADVN---TQGLDD--DTPLHDSASSGHRDIVKLLLRHGGNP 254
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 58.2 bits (139), Expect = 2e-08
Identities = 40/120 (33%), Positives = 63/120 (52%), Gaps = 18/120 (15%)
Query: 132 DGINTMSEQGMTPLMYACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTAL 191
D +N +E+G TPL A +RGD V+ L+ GA++NV+ + WT L
Sbjct: 176 DKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVK-------------DFAGWTPL 222
Query: 192 TFAVLHGHIPVVQLLLDAGAKVEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADP 251
A G+ V ++L+ AGA V G ++ +TPL +A+ G+ ++V LLL G +P
Sbjct: 223 HEACNVGYYDVAKILIAAGADVN---TQGLDD--DTPLHDSASSGHRDIVKLLLRHGGNP 277
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 58.2 bits (139), Expect = 2e-08
Identities = 45/160 (28%), Positives = 77/160 (48%), Gaps = 8/160 (5%)
Query: 444 KQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDGTCIEI- 502
+QT + ++L +K++ DV + R AH+++L + S F A+ ++ + EI
Sbjct: 158 EQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTND-VREARQEEIK 216
Query: 503 --GYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSIN 560
G S++ L+ QY Y G E +K + I LLS A QL + C K ++
Sbjct: 217 MEGVEPNSLWSLI-QYAYTGRLE---LKEDNIECLLSTACLLQLSQVVEACCKFLMKQLH 272
Query: 561 TDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAF 600
NC+ I + A G T+L Y +++ M +I N+ F
Sbjct: 273 PSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEF 312
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,593,902
Number of Sequences: 37866
Number of extensions: 1067950
Number of successful extensions: 5025
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 207
Number of HSP's successfully gapped in prelim test: 215
Number of HSP's that attempted gapping in prelim test: 2838
Number of HSP's gapped (non-prelim): 1239
length of query: 641
length of database: 18,247,518
effective HSP length: 109
effective length of query: 532
effective length of database: 14,120,124
effective search space: 7511905968
effective search space used: 7511905968
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.