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Search of human proteins with 62912472
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
(915 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 1839 0.0
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 1804 0.0
gi|62912474 leucine-rich repeat-containing G protein-coupled rec... 1510 0.0
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 926 0.0
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 742 0.0
gi|31657138 follicle stimulating hormone receptor isoform 1 prec... 174 3e-43
gi|31657136 follicle stimulating hormone receptor isoform 2 prec... 165 2e-40
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 154 5e-37
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 154 5e-37
gi|225579152 insulin-like growth factor binding protein, acid la... 152 1e-36
gi|4826772 insulin-like growth factor binding protein, acid labi... 152 1e-36
gi|64085121 thyroid stimulating hormone receptor isoform 1 precu... 151 3e-36
gi|106067657 luteinizing hormone/choriogonadotropin receptor pre... 147 4e-35
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 133 7e-31
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 128 2e-29
gi|4759146 slit homolog 2 [Homo sapiens] 126 1e-28
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 125 2e-28
gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo... 124 5e-28
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 123 7e-28
gi|188528675 slit homolog 1 [Homo sapiens] 122 1e-27
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 122 2e-27
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 120 8e-27
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 120 8e-27
gi|198041768 synleurin [Homo sapiens] 119 2e-26
gi|193083139 leucine rich repeat containing 32 precursor [Homo s... 119 2e-26
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap... 119 2e-26
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 118 3e-26
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 115 2e-25
gi|45505137 podocan [Homo sapiens] 114 4e-25
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 112 1e-24
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 1839 bits (4764), Expect = 0.0
Identities = 915/915 (100%), Positives = 915/915 (100%)
Query: 1 MGRPRLTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSG 60
MGRPRLTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSG
Sbjct: 1 MGRPRLTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSG 60
Query: 61 LYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDN 120
LYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDN
Sbjct: 61 LYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDN 120
Query: 121 ALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEG 180
ALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEG
Sbjct: 121 ALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEG 180
Query: 181 LHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNP 240
LHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNP
Sbjct: 181 LHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNP 240
Query: 241 IQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLP 300
IQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLP
Sbjct: 241 IQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLP 300
Query: 301 RLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRS 360
RLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRS
Sbjct: 301 RLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRS 360
Query: 361 IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILE 420
IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILE
Sbjct: 361 IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILE 420
Query: 421 VPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQL 480
VPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQL
Sbjct: 421 VPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQL 480
Query: 481 EMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPV 540
EMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPV
Sbjct: 481 EMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPV 540
Query: 541 PLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLG 600
PLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLG
Sbjct: 541 PLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLG 600
Query: 601 SEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYG 660
SEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYG
Sbjct: 601 SEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYG 660
Query: 661 ASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMV 720
ASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMV
Sbjct: 661 ASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMV 720
Query: 721 RHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNP 780
RHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNP
Sbjct: 721 RHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNP 780
Query: 781 HFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLE 840
HFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLE
Sbjct: 781 HFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLE 840
Query: 841 TYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSG 900
TYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSG
Sbjct: 841 TYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSG 900
Query: 901 GGGFQPSGLAFASHV 915
GGGFQPSGLAFASHV
Sbjct: 901 GGGFQPSGLAFASHV 915
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 1804 bits (4672), Expect = 0.0
Identities = 896/896 (100%), Positives = 896/896 (100%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA
Sbjct: 72 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 131
Query: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM
Sbjct: 132 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 191
Query: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 199
TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV
Sbjct: 192 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 251
Query: 200 AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 259
AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS
Sbjct: 252 AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 311
Query: 260 LNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLH 319
LNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLH
Sbjct: 312 LNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLH 371
Query: 320 RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD 379
RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD
Sbjct: 372 RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD 431
Query: 380 NQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKA 439
NQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKA
Sbjct: 432 NQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKA 491
Query: 440 SGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGP 499
SGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGP
Sbjct: 492 SGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGP 551
Query: 500 FKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLT 559
FKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLT
Sbjct: 552 FKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLT 611
Query: 560 GISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV 619
GISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV
Sbjct: 612 GISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV 671
Query: 620 SCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALG 679
SCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALG
Sbjct: 672 SCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALG 731
Query: 680 FTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAF 739
FTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAF
Sbjct: 732 FTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAF 791
Query: 740 LSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPL 799
LSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPL
Sbjct: 792 LSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPL 851
Query: 800 AYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPR 859
AYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPR
Sbjct: 852 AYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPR 911
Query: 860 LEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV 915
LEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV
Sbjct: 912 LEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV 967
>gi|62912474 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 3 [Homo sapiens]
Length = 828
Score = 1510 bits (3909), Expect = 0.0
Identities = 753/799 (94%), Positives = 768/799 (96%)
Query: 117 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 176
L N LTE+ ++L L+ + L+ N +SHIP AF L SL +L L NN++ +
Sbjct: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
Query: 177 SFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 236
+ L +L++LDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF
Sbjct: 90 ALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 149
Query: 237 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 296
YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC
Sbjct: 150 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 209
Query: 297 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 356
QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN
Sbjct: 210 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 269
Query: 357 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 416
AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL
Sbjct: 270 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 329
Query: 417 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 476
RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD
Sbjct: 330 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 389
Query: 477 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 536
ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA
Sbjct: 390 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 449
Query: 537 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 596
GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL
Sbjct: 450 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 509
Query: 597 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 656
AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV
Sbjct: 510 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 569
Query: 657 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD 716
GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD
Sbjct: 570 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD 629
Query: 717 CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL 776
CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL
Sbjct: 630 CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL 689
Query: 777 LFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP 836
LFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP
Sbjct: 690 LFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP 749
Query: 837 PGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGG 896
PGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGG
Sbjct: 750 PGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGG 809
Query: 897 GLSGGGGFQPSGLAFASHV 915
GLSGGGGFQPSGLAFASHV
Sbjct: 810 GLSGGGGFQPSGLAFASHV 828
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 926 bits (2392), Expect = 0.0
Identities = 475/855 (55%), Positives = 607/855 (70%), Gaps = 18/855 (2%)
Query: 8 LVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKIL 67
L +S+ S DLSMNN+++L P LRFLEELRL+GN L++IP AF+GLYSLK+L
Sbjct: 60 LPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVL 119
Query: 68 MLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPV 127
MLQNNQL +P EAL L SLQSLRLDAN IS VP F GL SLRHLWLDDNALTEIPV
Sbjct: 120 MLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPV 179
Query: 128 RALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETL 187
+A +L ALQAMTLALN+I HIPDYAF NL+SLVVLHLHNNRI LG F+GLH+LETL
Sbjct: 180 QAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETL 239
Query: 188 DLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRS 247
DLNYN L EFP AIRTL L+ELGFH+NNI++IPEKAF+GNP L TIHFYDNPIQFVGRS
Sbjct: 240 DLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRS 299
Query: 248 AFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLEL 307
AFQ+LP+L TL+LNGA I EFPDL GT +LE LTLT A I LP +C QLP L+VL+L
Sbjct: 300 AFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDL 359
Query: 308 SHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFS 367
S+N +E+LPS CQKL++I L+HN I+EI DTF QL SL++L+L+WN I IHP AFS
Sbjct: 360 SYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFS 419
Query: 368 TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQC 427
TL SL+KLDL+ N L++ P+ GL GL HLKL GN AL S ++FP+L+++E+PYAYQC
Sbjct: 420 TLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQC 479
Query: 428 CPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEM-EDSK 486
C +G+C + +K S QW D + ++ K+ G+ Q E +DL++ L+ ED K
Sbjct: 480 CAFGVCENAYKISNQWNKGD-NSSMDDLHKKDAGMFQAQDE----RDLEDFLLDFEEDLK 534
Query: 487 PHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVK 546
SVQCSP+PGPFKPCE+L + W IR+ VW I +L++ CN LV TVF P+ + P+K
Sbjct: 535 ALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFR-SPLYISPIK 593
Query: 547 FVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVL 606
++G IA N LTG+S +LA VDA TFG F+ +GA WE G+GC GFL++ SE+SV
Sbjct: 594 LLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVF 653
Query: 607 LLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCL 666
LLTLAA++ SV + S++ +L C LA AA+PL +YGASPLCL
Sbjct: 654 LLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCL 713
Query: 667 PYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWL 726
P P G+P+ +G+ VAL+++NS CFL++ AY KLYC+L +GD E +WDC+MV+H+A L
Sbjct: 714 PL--PFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALL 771
Query: 727 IFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 786
+F + +L CPVAFLSF+S++ L ++PE +K +LLVV+PLPACLNPLLY+LFNPHF++DL
Sbjct: 772 LFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
Query: 787 RRLRPRA-----GDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP----P 837
LR + L + ++EK SCDSTQALV F+ + + + P P
Sbjct: 832 VSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYP 891
Query: 838 GLETYGFPSVTLISC 852
E+ SV + C
Sbjct: 892 VTESCHLSSVAFVPC 906
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 742 bits (1916), Expect = 0.0
Identities = 404/855 (47%), Positives = 534/855 (62%), Gaps = 28/855 (3%)
Query: 12 VSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQN 71
+S A D+SMNN+T+L F + FLEEL+L+GN LS I +A SGL LK+L LQN
Sbjct: 55 LSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQN 114
Query: 72 NQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALN 131
NQL +P+EA+ L +LQSLRLDAN I+ VPE SFEGL LRHLWLDDN+LTE+PV L+
Sbjct: 115 NQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLS 174
Query: 132 NLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNY 191
NLP LQA+TLALN+IS IPD+AF NL+SLVVLHLHNN+I+ L H F+GL NLETLDLNY
Sbjct: 175 NLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNY 234
Query: 192 NKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQY 251
N L EFP AI+ L L+ELGFH+N+I IP+ AF GNPLL+TIH YDNP+ FVG SAF
Sbjct: 235 NNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHN 294
Query: 252 LPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ 311
L LH+L + GA +Q+FP+L GT LE LTLT I +P+ +CQ+ LR L+LS+N
Sbjct: 295 LSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNN 354
Query: 312 IEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHS 371
I +LPS + C LEEI LQ N+I++I TF L SL+ LDLS N I IH AF+TL
Sbjct: 355 IRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGP 414
Query: 372 LVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYG 431
+ LD++ N+LT+ P GL GL LKL GN L +A + F LR L VPYAYQCC +
Sbjct: 415 ITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFW 474
Query: 432 MCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSV 491
C S+ + + + H +E + EN + +
Sbjct: 475 GCDSYANLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQI--------------II 520
Query: 492 QCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGA 551
C+P+ G FKPCEYL SW IRL VW I L+++ N LV+LT FA LP K +G
Sbjct: 521 HCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFA-SCTSLPSSKLFIGL 579
Query: 552 IAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLA 611
I+ +N GI G+L +DA+++G+F+E+G WETG GC+ GFLAV SE+++ LL LA
Sbjct: 580 ISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLA 639
Query: 612 AVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 671
V+ S+S + GKS L R L A +A PL GEY ASPLCLP+ P
Sbjct: 640 TVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPF--P 697
Query: 672 EGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADG 731
G+ +LGFTV LV++NS FL++A Y KLYC+L + D +M++HVAWLIF +
Sbjct: 698 TGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNC 757
Query: 732 LLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDD----LR 787
+ +CPVAF SFA ++ ++PE +KSV L+ PLPACLNP+LY+ FNP F++D R
Sbjct: 758 IFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKR 817
Query: 788 RLRPRAGDSGPLAYAAAGELEKS---SCDSTQALVAFSDVDLILEASEAGRPPG----LE 840
R+ ++G + G LE+ C L V E+ +P ++
Sbjct: 818 RVTKKSGSVSVSISSQGGCLEQDFYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIK 877
Query: 841 TYGFPSVTLISCQQP 855
++ P++ + SCQ+P
Sbjct: 878 SHSCPALAVASCQRP 892
Score = 50.8 bits (120), Expect = 6e-06
Identities = 33/105 (31%), Positives = 51/105 (48%), Gaps = 2/105 (1%)
Query: 9 VCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILM 68
+CQ ++ DLS NN+ +L F+ LEE+ L N + I F GL SL+IL
Sbjct: 338 LCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILD 395
Query: 69 LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLR 113
L N + I + A L + +L + N ++ P GL+ L+
Sbjct: 396 LSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK 440
>gi|31657138 follicle stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 695
Score = 174 bits (442), Expect = 3e-43
Identities = 154/634 (24%), Positives = 277/634 (43%), Gaps = 49/634 (7%)
Query: 209 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI-QFVGRSAFQYLPKLHTLSLNGAMDIQ 267
EL F ++ I + AF G L+ I N + + + F LPKLH + + A ++
Sbjct: 50 ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLL 109
Query: 268 EF-PD-LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLE 325
P+ + +L+ L ++ GI+ LP + ++ L+ I++ ++H ++
Sbjct: 110 YINPEAFQNLPNLQYLLISNTGIKHLPD-----VHKIHSLQKVLLDIQDNINIHTIERNS 164
Query: 326 EIGLQH---------NRIWEIGADTFSQLSSLQALDLSWNA-IRSIHPEAFSTLHSLVKL 375
+GL N I EI F+ + L L+LS N + + + F V L
Sbjct: 165 FVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDELNLSDNNNLEELPNDVFHGASGPVIL 223
Query: 376 DLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCAS 435
D++ ++ +LP GL L L+ + L + + + L + Y CC +
Sbjct: 224 DISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAF----- 278
Query: 436 FFKASGQWEAEDLH-----------LDDEESSKRPLGLLARQAENHYDQDLDELQLEMED 484
A+ + + +LH +D ++ LA E+ Y + D E +
Sbjct: 279 ---ANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDY 335
Query: 485 SKPHP--SVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPL 542
+ V CSP P F PCE + +R+ +W I +L++ N +++L + L
Sbjct: 336 DLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGN-IIVLVILTTSQYKL 394
Query: 543 PPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSE 602
+F++ +A A+ GI L+ASVD T Q+ Y W+TG GC A GF V SE
Sbjct: 395 TVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASE 454
Query: 603 ASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGAS 662
SV LT ++ +++ L + ++ A AA P+ + Y
Sbjct: 455 LSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKV 514
Query: 663 PLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVR 721
+CLP P + + ++L+++N F+V+ G YI +Y + + + D + +
Sbjct: 515 SICLPM--DIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAK 572
Query: 722 HVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPH 781
+A LIF D L P++F + ++ L + +T K +L++ P+ +C NP LY +F +
Sbjct: 573 RMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKN 632
Query: 782 FRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDST 815
FR D L + G Y ++ ++ ST
Sbjct: 633 FRRDFFILLSKCG-----CYEMQAQIYRTETSST 661
Score = 53.5 bits (127), Expect = 9e-07
Identities = 68/249 (27%), Positives = 101/249 (40%), Gaps = 34/249 (13%)
Query: 42 ELRLSGNHLSHIPGQAFSGLYSL-KILMLQNNQLGGIPAEALWELPSLQSLRLDA--NLI 98
ELR L I AFSG L KI + QN+ L I A+ LP L +R++ NL+
Sbjct: 50 ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLL 109
Query: 99 SLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLT 158
+ PE A NLP LQ + ++ I H+PD +
Sbjct: 110 YINPE-------------------------AFQNLPNLQYLLISNTGIKHLPDVHKIHSL 144
Query: 159 SLVVLHLHNN-RIQHLGTHSFEGL-HNLETLDLNYNKLQEFPVAIRTLGRLQELGF-HNN 215
V+L + +N I + +SF GL L LN N +QE +L EL NN
Sbjct: 145 QKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNN 204
Query: 216 NIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGT 275
N++ +P F G + I + + L KL S ++++ P L+
Sbjct: 205 NLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARS---TYNLKKLPTLEKL 261
Query: 276 TSLEILTLT 284
+L +LT
Sbjct: 262 VALMEASLT 270
Score = 43.5 bits (101), Expect = 9e-04
Identities = 41/165 (24%), Positives = 63/165 (38%), Gaps = 30/165 (18%)
Query: 24 NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALW 83
NNL + P F +L L+ L +S + H+P +
Sbjct: 106 NNLLYINPEAFQNLPNLQYLLISNTGIKHLPD--------------------------VH 139
Query: 84 ELPSLQSLRLDAN---LISLVPERSFEGLS-SLRHLWLDDNALTEIPVRALNNLPALQAM 139
++ SLQ + LD I + SF GLS LWL+ N + EI A N +
Sbjct: 140 KIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELN 199
Query: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNL 184
N + +P+ F + V+L + RI L ++ E L L
Sbjct: 200 LSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKL 244
>gi|31657136 follicle stimulating hormone receptor isoform 2
precursor [Homo sapiens]
Length = 633
Score = 165 bits (417), Expect = 2e-40
Identities = 165/614 (26%), Positives = 268/614 (43%), Gaps = 71/614 (11%)
Query: 209 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI-QFVGRSAFQYLPKLHTLSLNGAMDIQ 267
EL F ++ I + AF G L+ I N + + + F LPKLH + + A ++
Sbjct: 50 ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNL- 108
Query: 268 EFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEI 327
+ + P Q LP L+ L +S+ I+ LP +H+ L+++
Sbjct: 109 --------------------LYINPEAF-QNLPNLQYLLISNTGIKHLPDVHKIHSLQKV 147
Query: 328 --GLQHN-RIWEIGADTFSQLS-SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD-NQL 382
+Q N I I ++F LS L L+ N I+ IH AF+ L +L+L+D N L
Sbjct: 148 LLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNL 206
Query: 383 TTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQ 442
LP G G + LS+ + LR EV Y Q A GQ
Sbjct: 207 EELPNDVFHG-----ASGPVILSELHPICNKSILR-QEVDYMTQ------------ARGQ 248
Query: 443 WEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKP 502
L D+E S R + +D DL E+ D V CSP P F P
Sbjct: 249 --RSSLAEDNESSYSRGFDM----TYTEFDYDLCN---EVVD------VTCSPKPDAFNP 293
Query: 503 CEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGIS 562
CE + +R+ +W I +L++ N +++L + L +F++ +A A+ GI
Sbjct: 294 CEDIMGYNILRVLIWFISILAITGN-IIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIY 352
Query: 563 CGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCV 622
L+ASVD T Q+ Y W+TG GC A GF V SE SV LT ++ +++
Sbjct: 353 LLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHA 412
Query: 623 RAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTV 682
L + ++ A AA P+ + Y +CLP P + + +
Sbjct: 413 MQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPM--DIDSPLSQLYVM 470
Query: 683 ALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVRHVAWLIFADGLLYCPVAFLS 741
+L+++N F+V+ G YI +Y + + + D + + +A LIF D L P++F +
Sbjct: 471 SLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFA 530
Query: 742 FASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAY 801
++ L + +T K +L++ P+ +C NP LY +F +FR D L + G Y
Sbjct: 531 ISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCG-----CY 585
Query: 802 AAAGELEKSSCDST 815
++ ++ ST
Sbjct: 586 EMQAQIYRTETSST 599
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/192 (30%), Positives = 81/192 (42%), Gaps = 31/192 (16%)
Query: 42 ELRLSGNHLSHIPGQAFSGLYSL-KILMLQNNQLGGIPAEALWELPSLQSLRLDA--NLI 98
ELR L I AFSG L KI + QN+ L I A+ LP L +R++ NL+
Sbjct: 50 ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLL 109
Query: 99 SLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLT 158
+ PE A NLP LQ + ++ I H+PD +
Sbjct: 110 YINPE-------------------------AFQNLPNLQYLLISNTGIKHLPDVHKIHSL 144
Query: 159 SLVVLHLHNN-RIQHLGTHSFEGL-HNLETLDLNYNKLQEFPVAIRTLGRLQELGF-HNN 215
V+L + +N I + +SF GL L LN N +QE +L EL NN
Sbjct: 145 QKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNN 204
Query: 216 NIKAIPEKAFMG 227
N++ +P F G
Sbjct: 205 NLEELPNDVFHG 216
Score = 33.9 bits (76), Expect = 0.71
Identities = 35/144 (24%), Positives = 54/144 (37%), Gaps = 30/144 (20%)
Query: 24 NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALW 83
NNL + P F +L L+ L +S + H+P +
Sbjct: 106 NNLLYINPEAFQNLPNLQYLLISNTGIKHLPD--------------------------VH 139
Query: 84 ELPSLQSLRLDAN---LISLVPERSFEGLS-SLRHLWLDDNALTEIPVRALNNLPALQAM 139
++ SLQ + LD I + SF GLS LWL+ N + EI A N +
Sbjct: 140 KIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELN 199
Query: 140 TLALNRISHIPDYAFQNLTSLVVL 163
N + +P+ F + V+L
Sbjct: 200 LSDNNNLEELPNDVFHGASGPVIL 223
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 154 bits (388), Expect = 5e-37
Identities = 114/361 (31%), Positives = 172/361 (47%), Gaps = 6/361 (1%)
Query: 25 NLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWE 84
++TEL F ++ L LR+ N LS I AF L SL+ L L NN+L +P
Sbjct: 70 HITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQG 129
Query: 85 LPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALN 144
L SL+SL L +N + + F S+L+ L L N L IP A ++L L + L N
Sbjct: 130 LDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 189
Query: 145 RISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRT 203
++HI FQ+L +L VL L+ NR+ + +F+GL NL+ L L N++ P
Sbjct: 190 SLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN 249
Query: 204 LGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGA 263
LQ L NN+I +P FM P L + + N ++ + F +P L L L
Sbjct: 250 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD- 308
Query: 264 MDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LH 319
I PD L++L L+R I + G L LR L L N +++L
Sbjct: 309 NHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFR 368
Query: 320 RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD 379
L+ I LQ+NR+ ++ + F+ ++ L A+ L N + ++ F L L +L L D
Sbjct: 369 MLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD 428
Query: 380 N 380
N
Sbjct: 429 N 429
Score = 147 bits (372), Expect = 3e-35
Identities = 111/366 (30%), Positives = 176/366 (48%), Gaps = 7/366 (1%)
Query: 43 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 102
L++ H++ + F + +L L ++ N+L I A L SL+ L L N + ++P
Sbjct: 64 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 123
Query: 103 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVV 162
F+GL SL L L N L +I + L+ + L N + +IPD AF +L L
Sbjct: 124 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTK 183
Query: 163 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIP 221
L+L N + H+ F+ L NL+ L L N+L + P+ L LQEL N I +
Sbjct: 184 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 243
Query: 222 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG-AMDIQEFPDLKGTTSLEI 280
F N LQ ++ +N I + S F LP+L+ L+L G ++ +L
Sbjct: 244 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 303
Query: 281 LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIG 338
L L I LP + L +L+VL LS NQI + + + +L E+ L N + ++
Sbjct: 304 LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLD 363
Query: 339 ADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLA---GLGGLMH 395
+ F L++LQ + L N +R + F+ ++ L+ + L +NQL LPL LG L
Sbjct: 364 GNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCE 423
Query: 396 LKLKGN 401
L+L N
Sbjct: 424 LRLYDN 429
Score = 126 bits (317), Expect = 8e-29
Identities = 85/242 (35%), Positives = 119/242 (49%), Gaps = 1/242 (0%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
+L N+LT + P +F HL L+ LRL N L+ IP F GL +L+ L LQ NQ+G +
Sbjct: 185 NLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSP 244
Query: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
+LQ L L N IS +P F L L L L N+L E+ + +P L+ +
Sbjct: 245 GLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLREL 304
Query: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 199
L N IS +PD F NL L VL L N+I + +F GL L L L+ N LQ+
Sbjct: 305 WLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDG 364
Query: 200 AI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTL 258
+ R L LQ + NN ++ +P F L I +N ++ + F +L KL L
Sbjct: 365 NVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCEL 424
Query: 259 SL 260
L
Sbjct: 425 RL 426
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 154 bits (388), Expect = 5e-37
Identities = 114/361 (31%), Positives = 172/361 (47%), Gaps = 6/361 (1%)
Query: 25 NLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWE 84
++TEL F ++ L LR+ N LS I AF L SL+ L L NN+L +P
Sbjct: 64 HITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQG 123
Query: 85 LPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALN 144
L SL+SL L +N + + F S+L+ L L N L IP A ++L L + L N
Sbjct: 124 LDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 183
Query: 145 RISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRT 203
++HI FQ+L +L VL L+ NR+ + +F+GL NL+ L L N++ P
Sbjct: 184 SLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN 243
Query: 204 LGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGA 263
LQ L NN+I +P FM P L + + N ++ + F +P L L L
Sbjct: 244 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD- 302
Query: 264 MDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LH 319
I PD L++L L+R I + G L LR L L N +++L
Sbjct: 303 NHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFR 362
Query: 320 RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD 379
L+ I LQ+NR+ ++ + F+ ++ L A+ L N + ++ F L L +L L D
Sbjct: 363 MLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD 422
Query: 380 N 380
N
Sbjct: 423 N 423
Score = 147 bits (372), Expect = 3e-35
Identities = 111/366 (30%), Positives = 176/366 (48%), Gaps = 7/366 (1%)
Query: 43 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 102
L++ H++ + F + +L L ++ N+L I A L SL+ L L N + ++P
Sbjct: 58 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 117
Query: 103 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVV 162
F+GL SL L L N L +I + L+ + L N + +IPD AF +L L
Sbjct: 118 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTK 177
Query: 163 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIP 221
L+L N + H+ F+ L NL+ L L N+L + P+ L LQEL N I +
Sbjct: 178 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 237
Query: 222 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG-AMDIQEFPDLKGTTSLEI 280
F N LQ ++ +N I + S F LP+L+ L+L G ++ +L
Sbjct: 238 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 297
Query: 281 LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIG 338
L L I LP + L +L+VL LS NQI + + + +L E+ L N + ++
Sbjct: 298 LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLD 357
Query: 339 ADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLA---GLGGLMH 395
+ F L++LQ + L N +R + F+ ++ L+ + L +NQL LPL LG L
Sbjct: 358 GNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCE 417
Query: 396 LKLKGN 401
L+L N
Sbjct: 418 LRLYDN 423
Score = 126 bits (317), Expect = 8e-29
Identities = 85/242 (35%), Positives = 119/242 (49%), Gaps = 1/242 (0%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
+L N+LT + P +F HL L+ LRL N L+ IP F GL +L+ L LQ NQ+G +
Sbjct: 179 NLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSP 238
Query: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
+LQ L L N IS +P F L L L L N+L E+ + +P L+ +
Sbjct: 239 GLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLREL 298
Query: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 199
L N IS +PD F NL L VL L N+I + +F GL L L L+ N LQ+
Sbjct: 299 WLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDG 358
Query: 200 AI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTL 258
+ R L LQ + NN ++ +P F L I +N ++ + F +L KL L
Sbjct: 359 NVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCEL 418
Query: 259 SL 260
L
Sbjct: 419 RL 420
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 152 bits (384), Expect = 1e-36
Identities = 118/350 (33%), Positives = 173/350 (49%), Gaps = 6/350 (1%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
+L N+L L F L L EL L+GN L+++ FSGL L+ L L N L I A
Sbjct: 214 NLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKA 273
Query: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
+LP LQ L LD NLI+ V +F GL +LR L L N + + L L+ +
Sbjct: 274 NVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVL 333
Query: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 199
L+ N I+ + F++L L L L +NRI+ L SFEGL LE L L++N+LQE
Sbjct: 334 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKA 393
Query: 200 -AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTL 258
A L + + N ++ +PE+ F G L ++H + + + F L L L
Sbjct: 394 GAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRL 453
Query: 259 SL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP 316
L NG + I+E L G L L LT + LP + Q L +L L LS N++ ELP
Sbjct: 454 FLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELP 512
Query: 317 --SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 364
+L Q+ + + HNR+ + + L L+ L L N++R+ P+
Sbjct: 513 ADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ 562
Score = 147 bits (371), Expect = 4e-35
Identities = 121/392 (30%), Positives = 189/392 (48%), Gaps = 9/392 (2%)
Query: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75
+++ LS N L+ L+ GLF L L +L L N L+ +P AF GL SL+ L+L N+L
Sbjct: 186 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 245
Query: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 135
+ L L+ L L N + + F L L+ L+LD N + + A L A
Sbjct: 246 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 305
Query: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
L+ + L+ NR++ + + F L L VL L +N I L +F+ LH LE L L +N+++
Sbjct: 306 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 365
Query: 196 EFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPK 254
+ + LG+L+ L +N ++ + AF+G + ++ N ++ + F+ L K
Sbjct: 366 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 425
Query: 255 LHTLSLNGAMDIQEFPD-LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIE 313
LH+L L G+ + P G + L L L G+ + L L L+L+ NQ+
Sbjct: 426 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 485
Query: 314 ELPSLHRC----QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL 369
LP HR KLE + L NR+ E+ AD L LD+S N + ++ + L
Sbjct: 486 HLP--HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPL 543
Query: 370 HSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 401
L L L +N L T GL L L+GN
Sbjct: 544 GRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 574
Score = 144 bits (363), Expect = 4e-34
Identities = 124/389 (31%), Positives = 183/389 (47%), Gaps = 9/389 (2%)
Query: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
L NNL+ + P F +L L L L G L + QA GL +L L L+ NQL +
Sbjct: 119 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALG 178
Query: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
P+L SL L N +S + + FEGL SL L L N+L +P A L +L+ +
Sbjct: 179 TFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELV 238
Query: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PV 199
LA NR++++ F L L L L N ++ + + F L L+ L L+ N + P
Sbjct: 239 LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPG 298
Query: 200 AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 259
A L L+ L +N + + E F G L+ + N I + F+ L L L
Sbjct: 299 AFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQ 358
Query: 260 LNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS 317
L G I++ + +G LE+LTL ++ + +G L + V+ LS N + LP
Sbjct: 359 L-GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPE 417
Query: 318 --LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 375
KL + L+ + + I TF+ LS L+ L L N + I ++ L L++L
Sbjct: 418 QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLEL 477
Query: 376 DLTDNQLTTLP---LAGLGGLMHLKLKGN 401
DLT NQLT LP GLG L +L L N
Sbjct: 478 DLTSNQLTHLPHRLFQGLGKLEYLLLSRN 506
Score = 138 bits (348), Expect = 2e-32
Identities = 125/389 (32%), Positives = 178/389 (45%), Gaps = 9/389 (2%)
Query: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
L N L L G F H L L LS N LS + F GL SL L L N L +P
Sbjct: 167 LERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDA 226
Query: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
A L SL+ L L N ++ + F GL+ LR L L NAL I LP LQ +
Sbjct: 227 AFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLY 286
Query: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PV 199
L N I+ + AF L +L L L +NR+ L +F GL L L L++N + P
Sbjct: 287 LDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPR 346
Query: 200 AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 259
+ L L+EL +N I+ + E++F G L+ + N +Q V AF L + ++
Sbjct: 347 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMN 406
Query: 260 LNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIE--EL 315
L+G ++ P+ +G L L L + + + L LR L L N + E
Sbjct: 407 LSGNC-LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 465
Query: 316 PSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 375
SL +L E+ L N++ + F L L+ L LS N + + +A L L
Sbjct: 466 QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWL 525
Query: 376 DLTDNQLTTLP---LAGLGGLMHLKLKGN 401
D++ N+L LP LA LG L +L L+ N
Sbjct: 526 DVSHNRLEALPNSLLAPLGRLRYLSLRNN 554
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 152 bits (384), Expect = 1e-36
Identities = 118/350 (33%), Positives = 173/350 (49%), Gaps = 6/350 (1%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
+L N+L L F L L EL L+GN L+++ FSGL L+ L L N L I A
Sbjct: 176 NLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKA 235
Query: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
+LP LQ L LD NLI+ V +F GL +LR L L N + + L L+ +
Sbjct: 236 NVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVL 295
Query: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 199
L+ N I+ + F++L L L L +NRI+ L SFEGL LE L L++N+LQE
Sbjct: 296 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKA 355
Query: 200 -AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTL 258
A L + + N ++ +PE+ F G L ++H + + + F L L L
Sbjct: 356 GAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRL 415
Query: 259 SL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP 316
L NG + I+E L G L L LT + LP + Q L +L L LS N++ ELP
Sbjct: 416 FLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELP 474
Query: 317 --SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 364
+L Q+ + + HNR+ + + L L+ L L N++R+ P+
Sbjct: 475 ADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ 524
Score = 147 bits (371), Expect = 4e-35
Identities = 121/392 (30%), Positives = 189/392 (48%), Gaps = 9/392 (2%)
Query: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75
+++ LS N L+ L+ GLF L L +L L N L+ +P AF GL SL+ L+L N+L
Sbjct: 148 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 207
Query: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 135
+ L L+ L L N + + F L L+ L+LD N + + A L A
Sbjct: 208 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 267
Query: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
L+ + L+ NR++ + + F L L VL L +N I L +F+ LH LE L L +N+++
Sbjct: 268 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
Query: 196 EFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPK 254
+ + LG+L+ L +N ++ + AF+G + ++ N ++ + F+ L K
Sbjct: 328 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 387
Query: 255 LHTLSLNGAMDIQEFPD-LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIE 313
LH+L L G+ + P G + L L L G+ + L L L+L+ NQ+
Sbjct: 388 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 447
Query: 314 ELPSLHRC----QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL 369
LP HR KLE + L NR+ E+ AD L LD+S N + ++ + L
Sbjct: 448 HLP--HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPL 505
Query: 370 HSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 401
L L L +N L T GL L L+GN
Sbjct: 506 GRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 536
Score = 144 bits (363), Expect = 4e-34
Identities = 124/389 (31%), Positives = 183/389 (47%), Gaps = 9/389 (2%)
Query: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
L NNL+ + P F +L L L L G L + QA GL +L L L+ NQL +
Sbjct: 81 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALG 140
Query: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
P+L SL L N +S + + FEGL SL L L N+L +P A L +L+ +
Sbjct: 141 TFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELV 200
Query: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PV 199
LA NR++++ F L L L L N ++ + + F L L+ L L+ N + P
Sbjct: 201 LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPG 260
Query: 200 AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 259
A L L+ L +N + + E F G L+ + N I + F+ L L L
Sbjct: 261 AFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQ 320
Query: 260 LNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS 317
L G I++ + +G LE+LTL ++ + +G L + V+ LS N + LP
Sbjct: 321 L-GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPE 379
Query: 318 --LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 375
KL + L+ + + I TF+ LS L+ L L N + I ++ L L++L
Sbjct: 380 QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLEL 439
Query: 376 DLTDNQLTTLP---LAGLGGLMHLKLKGN 401
DLT NQLT LP GLG L +L L N
Sbjct: 440 DLTSNQLTHLPHRLFQGLGKLEYLLLSRN 468
Score = 138 bits (348), Expect = 2e-32
Identities = 125/389 (32%), Positives = 178/389 (45%), Gaps = 9/389 (2%)
Query: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
L N L L G F H L L LS N LS + F GL SL L L N L +P
Sbjct: 129 LERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDA 188
Query: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
A L SL+ L L N ++ + F GL+ LR L L NAL I LP LQ +
Sbjct: 189 AFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLY 248
Query: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PV 199
L N I+ + AF L +L L L +NR+ L +F GL L L L++N + P
Sbjct: 249 LDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPR 308
Query: 200 AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 259
+ L L+EL +N I+ + E++F G L+ + N +Q V AF L + ++
Sbjct: 309 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMN 368
Query: 260 LNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIE--EL 315
L+G ++ P+ +G L L L + + + L LR L L N + E
Sbjct: 369 LSGNC-LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 427
Query: 316 PSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 375
SL +L E+ L N++ + F L L+ L LS N + + +A L L
Sbjct: 428 QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWL 487
Query: 376 DLTDNQLTTLP---LAGLGGLMHLKLKGN 401
D++ N+L LP LA LG L +L L+ N
Sbjct: 488 DVSHNRLEALPNSLLAPLGRLRYLSLRNN 516
>gi|64085121 thyroid stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 764
Score = 151 bits (381), Expect = 3e-36
Identities = 174/727 (23%), Positives = 306/727 (42%), Gaps = 62/727 (8%)
Query: 134 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN-RIQHLGTHSFEGLHNLETLDLNYN 192
P+ Q + L + IP +AF NL ++ +++ + +Q L +HSF L + +++
Sbjct: 52 PSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNT 111
Query: 193 KLQEF--PVAIRTLGRLQELGFHNNNIKAIPEKAFM-GNPLLQTIHFYDNP-IQFVGRSA 248
+ + P A++ L L+ LG N +K P+ + + + DNP + + +A
Sbjct: 112 RNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNA 171
Query: 249 FQYLPKLHTLSL----NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS---GMCQQLPR 301
FQ L TL+L NG +Q + GT + + ++ G P
Sbjct: 172 FQGLCN-ETLTLKLYNNGFTSVQGYA-FNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPS 229
Query: 302 LRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFS-QLSSLQALDLSWNAIRS 360
L L++S + LPS + L+E+ ++ W + S L DLS+ +
Sbjct: 230 L--LDVSQTSVTALPS-KGLEHLKELIARNT--WTLKKLPLSLSFLHLTRADLSYPSHCC 284
Query: 361 IHPEAFSTLHSLVKLDLTDNQLTTL----PLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 416
L L ++ + +L + L +H + + NL S K+
Sbjct: 285 AFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQ 344
Query: 417 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 476
+ Y FF+ E ED + + K P + ++HYD +
Sbjct: 345 DTHNNAHYYV---------FFE-----EQEDEIIGFGQELKNPQEETLQAFDSHYDYTI- 389
Query: 477 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 536
DS+ + C+P F PCE + +R+ VW + LL++L N VLL +
Sbjct: 390 -----CGDSE---DMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLT 441
Query: 537 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 596
L +F++ +A A+ G+ L+ASVD T ++ + W+TG GC GF
Sbjct: 442 SH-YKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFF 500
Query: 597 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 656
V SE SV LT+ ++ +++ + L A ++G L A LPL +
Sbjct: 501 TVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGI 560
Query: 657 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFE-AVW 715
Y +CLP P AL + V ++ +N F++V Y+K+Y + +
Sbjct: 561 SSYAKVSICLPM--DTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDK 618
Query: 716 DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLY 775
D + + +A LIF D + P++F + +++L +T K +L++ PL +C NP LY
Sbjct: 619 DTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLY 678
Query: 776 LLFNPHFRDDLRRLRPRAGDSGPLAYAAAG-----------ELEKSSCDSTQALVAFSDV 824
+F F+ D+ L + G A A G +++K + + Q L DV
Sbjct: 679 AIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDV 738
Query: 825 DLILEAS 831
++E S
Sbjct: 739 YELIENS 745
Score = 38.9 bits (89), Expect = 0.022
Identities = 55/253 (21%), Positives = 103/253 (40%), Gaps = 18/253 (7%)
Query: 195 QEFPVAIRTLGRL-------QELGFHNNNIKAIPEKAFMGNPLLQTIHF-YDNPIQFVGR 246
++F V + + R+ Q L +++ IP AF P + I+ D +Q +
Sbjct: 35 EDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLES 94
Query: 247 SAFQYLPKLHTLSLNGAMDIQEF-PD-LKGTTSLEILTLTRAGIRLLPS-GMCQQLPRLR 303
+F L K+ + + ++ PD LK L+ L + G+++ P
Sbjct: 95 HSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFF 154
Query: 304 VLELSHNQIEELPSLHR----CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNA-I 358
+LE++ N ++ C + + L +N + F+ + L A+ L+ N +
Sbjct: 155 ILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNG-TKLDAVYLNKNKYL 213
Query: 359 RSIHPEAFSTLHSLVKL-DLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLR 417
I +AF ++S L D++ +T LP GL L L + L + SF L
Sbjct: 214 TVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLT 273
Query: 418 ILEVPYAYQCCPY 430
++ Y CC +
Sbjct: 274 RADLSYPSHCCAF 286
Score = 33.5 bits (75), Expect = 0.93
Identities = 53/213 (24%), Positives = 92/213 (43%), Gaps = 35/213 (16%)
Query: 41 EELRLSGNHLSHIPGQAFSGL----------------------YSLK----ILMLQNNQL 74
+ L+L HL IP AFS L Y+L I + L
Sbjct: 55 QTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNL 114
Query: 75 GGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLW--LDDNALTEIPVRALNN 132
I +AL ELP L+ L + + + P+ + + + + D+ +T IPV A
Sbjct: 115 TYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQG 174
Query: 133 LPALQAMTLAL--NRISHIPDYAFQNLTSLVVLHLHNNR-IQHLGTHSFEGLHNLETLDL 189
L + +TL L N + + YAF N T L ++L+ N+ + + +F G+++ +L L
Sbjct: 175 L-CNETLTLKLYNNGFTSVQGYAF-NGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSL-L 231
Query: 190 NYNKLQEFPVAIRTLGRLQELGFHNN-NIKAIP 221
+ ++ + + L L+EL N +K +P
Sbjct: 232 DVSQTSVTALPSKGLEHLKELIARNTWTLKKLP 264
>gi|106067657 luteinizing hormone/choriogonadotropin receptor
precursor [Homo sapiens]
Length = 699
Score = 147 bits (371), Expect = 4e-35
Identities = 134/553 (24%), Positives = 234/553 (42%), Gaps = 49/553 (8%)
Query: 279 EILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHR------------CQKLE- 325
EIL +R + G LPRL+ L + + I + P + + C L
Sbjct: 102 EILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHI 161
Query: 326 ----------------EIGLQHNRIWEIGADTFSQLSSLQALDLSWNA-IRSIHPEAFST 368
+ L N E+ + F+ ++L +L+L N + +H AF
Sbjct: 162 TTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNG-TTLTSLELKENVHLEKMHNGAFRG 220
Query: 369 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC 428
LD++ +L LP GL + L + +L + S+++F L + Y CC
Sbjct: 221 ATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCC 280
Query: 429 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENH--YDQDLDELQLEMEDSK 486
F+ E H E SK+ + R+ N Y L E +L D +
Sbjct: 281 A-------FRNLPTKEQNFSHSISENFSKQCESTV-RKVNNKTLYSSMLAESELSGWDYE 332
Query: 487 PH----PSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPL 542
+ +C+P P F PCE + +R+ +W I +L+++ N + +L V L
Sbjct: 333 YGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGN-MTVLFVLLTSRYKL 391
Query: 543 PPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSE 602
+F++ ++ A+ G+ L+ASVD+ T GQ+ + W+TG GC GF V SE
Sbjct: 392 TVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASE 451
Query: 603 ASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGAS 662
SV LT+ ++ +++ + L +LG + L A LPL V Y
Sbjct: 452 LSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKV 511
Query: 663 PLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-WDCAMVR 721
+C P + + + ++++N F ++ YIK+Y + + A D + +
Sbjct: 512 SICFPM--DVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAK 569
Query: 722 HVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPH 781
+A LIF D P++F + ++ + +T K +L++ P+ +C NP LY +F
Sbjct: 570 KMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKT 629
Query: 782 FRDDLRRLRPRAG 794
F+ D L + G
Sbjct: 630 FQRDFFLLLSKFG 642
Score = 45.4 bits (106), Expect = 2e-04
Identities = 52/194 (26%), Positives = 89/194 (45%), Gaps = 11/194 (5%)
Query: 50 LSHIPGQAFSGLYSLKILMLQNNQ-LGGIPAEALWELPSLQSLRLDANLISLVPE--RSF 106
L I AF L +L +++QN + L I A LP L+ L + I P+ + F
Sbjct: 86 LERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVF 145
Query: 107 EGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLAL--NRISHIPDYAFQNLTSLVVLH 164
S+ D+ +T IP A + +++TL L N + +AF N T+L L
Sbjct: 146 SSESNFILEICDNLHITTIPGNAFQGMNN-ESVTLKLYGNGFEEVQSHAF-NGTTLTSLE 203
Query: 165 LHNN-RIQHLGTHSFEGLHNLETLDLNYNKLQEFP-VAIRTLGRLQELGFHNNNIKAIPE 222
L N ++ + +F G +TLD++ KLQ P + ++ RL + + ++K +P
Sbjct: 204 LKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRL--IATSSYSLKKLPS 261
Query: 223 KAFMGNPLLQTIHF 236
+ N L T+ +
Sbjct: 262 RETFVNLLEATLTY 275
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 133 bits (335), Expect = 7e-31
Identities = 98/344 (28%), Positives = 160/344 (46%), Gaps = 5/344 (1%)
Query: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
+S ++++ + PG F L L+ LRLS N ++H+PG + L+ L L +N L GI
Sbjct: 81 ISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQN 140
Query: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
+L +LQ L L+ N + +P F L +L+ L L N LT +P L L+ +
Sbjct: 141 MFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLL 200
Query: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVA 200
L NR+ + +L +L L H N I+ + +F+ L NL +L L+ N L P A
Sbjct: 201 LHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSA 260
Query: 201 IRTLG-RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 259
+ L L N + +P F LQ + ++ + +AF+ L +L L
Sbjct: 261 LFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLG 320
Query: 260 LNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS 317
+ + + P +G L++L L G+ LP G+ + L +LR + L N++ LP
Sbjct: 321 VTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPR 380
Query: 318 --LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIR 359
LE + L HN++ + D F L L + L N+ R
Sbjct: 381 ALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
Score = 125 bits (313), Expect = 2e-28
Identities = 99/358 (27%), Positives = 165/358 (46%), Gaps = 7/358 (1%)
Query: 29 LQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSL 88
LQ F + L+ L +S +H+S + FS L LK L L N++ +P L ++ L
Sbjct: 65 LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124
Query: 89 QSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISH 148
+ L LD N + + + F+ L +L+ L L+ N L +P NL L+ + L+ N ++H
Sbjct: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184
Query: 149 IPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRL 207
+P L L LH+NR+ L + L L L + N ++ P A L L
Sbjct: 185 LPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNL 244
Query: 208 QELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQ 267
L N++ +P F+ + L + ++NP+ + F + L L LN ++
Sbjct: 245 SSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLN-RTQLR 303
Query: 268 EFP--DLKGTTSLEILTLTRA-GIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQ 322
P + + L L +T + + LP G Q L L+VL L N + LP L
Sbjct: 304 TLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLG 363
Query: 323 KLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN 380
KL ++ L+ NR+ + F LSSL+++ L N + ++ + F L L ++ L N
Sbjct: 364 KLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
Score = 123 bits (308), Expect = 9e-28
Identities = 106/365 (29%), Positives = 170/365 (46%), Gaps = 11/365 (3%)
Query: 40 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLIS 99
L + L G + Q+FSG+ L+ LM+ ++ + + +L L++LRL N I+
Sbjct: 52 LTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKIT 111
Query: 100 LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTS 159
+P + + L L+LD NAL I L LQ + L N++ +P F NL +
Sbjct: 112 HLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLEN 171
Query: 160 LVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVA-IRTLGRLQELGFHNNNIK 218
L +L L N + HL LE L L+ N+L + +LG L EL FH N+I+
Sbjct: 172 LKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIR 231
Query: 219 AIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL--NGAMDIQE--FPDLKG 274
+I AF P L ++ N + F+ + F + L L+L N ++ F ++ G
Sbjct: 232 SIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGG 291
Query: 275 TTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHN-QIEELP--SLHRCQKLEEIGLQH 331
L+ L L R +R LP+ + L RLR L ++ + ++ LP + +L+ + L
Sbjct: 292 ---LQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHS 348
Query: 332 NRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLG 391
N + + L L+ + L N +R++ F L SL + L NQL TLP G
Sbjct: 349 NGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFG 408
Query: 392 GLMHL 396
L L
Sbjct: 409 ALPRL 413
Score = 111 bits (278), Expect = 3e-24
Identities = 91/325 (28%), Positives = 143/325 (44%), Gaps = 31/325 (9%)
Query: 14 IIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 73
+++ L N L + +F L L+EL L+ N L +P F+ L +LK+L L N
Sbjct: 122 VLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNN 181
Query: 74 LGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL 133
L +P L L+ L L +N + + L +L L N + I A + L
Sbjct: 182 LTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRL 241
Query: 134 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK 193
P L ++TL+ N ++ +P F + +L +L L N + L F + L+ L LN +
Sbjct: 242 PNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQ 301
Query: 194 LQEFP-VAIRTLGRLQELGFH-NNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQY 251
L+ P A R L RL+ LG + + A+P+ AF G LQ + + N
Sbjct: 302 LRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSN------------ 349
Query: 252 LPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSH 309
+ PD L+G L ++L R +R LP + + L L ++L H
Sbjct: 350 -------------GLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDH 396
Query: 310 NQIEELPS--LHRCQKLEEIGLQHN 332
NQ+E LP +L E+ L HN
Sbjct: 397 NQLETLPGDVFGALPRLTEVLLGHN 421
Score = 77.0 bits (188), Expect = 7e-14
Identities = 86/332 (25%), Positives = 136/332 (40%), Gaps = 48/332 (14%)
Query: 110 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR 169
++L H+ L + ++ + + LQ + ++ + IS + F +L L L L N+
Sbjct: 50 TNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNK 109
Query: 170 IQHL------------------------GTHSFEGLHNLETLDLNYNKLQEFPVAIRT-L 204
I HL + F+ L NL+ L LN N+L P ++ T L
Sbjct: 110 ITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNL 169
Query: 205 GRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN--- 261
L+ L NN+ +P+ L+ + + N + + L L L +
Sbjct: 170 ENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNH 229
Query: 262 ------GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 315
GA D P+L LTL+R + LPS + L +L L N + EL
Sbjct: 230 IRSIAPGAFD--RLPNLSS------LTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAEL 281
Query: 316 PSL--HRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE-AFSTLHSL 372
P + L+E+ L ++ + A F LS L+ L ++ + S P+ AF L L
Sbjct: 282 PGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGEL 341
Query: 373 VKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 401
L L N LT LP L GLG L + L+ N
Sbjct: 342 QVLALHSNGLTALPDGLLRGLGKLRQVSLRRN 373
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 128 bits (322), Expect = 2e-29
Identities = 108/352 (30%), Positives = 155/352 (44%), Gaps = 29/352 (8%)
Query: 56 QAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHL 115
+AF +L ++ N QL +A LP L+ L + + + F L+SL L
Sbjct: 67 RAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKL 126
Query: 116 WLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGT 175
L+ N L +P +L AL+++ L N++ +P FQ LT L L+L N + L
Sbjct: 127 TLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPE 186
Query: 176 HSFEGLHNLETLDLNYNKLQEFPVAI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI 234
F L +L+TL L+ N L P + LG LQEL +NNI +P + F L+ +
Sbjct: 187 ELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERL 246
Query: 235 HFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSG 294
N I + S F L L LSL M +R+LP+G
Sbjct: 247 WLQRNAITHLPLSIFASLGNLTFLSLQWNM-----------------------LRVLPAG 283
Query: 295 MCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALD 352
+ P L L L+HNQ+E + + L + L +N I + A F L L L
Sbjct: 284 LFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLY 343
Query: 353 LSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLG---GLMHLKLKGN 401
L N + ++HP F L L L L+ NQLTTLP L +L L GN
Sbjct: 344 LGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
Score = 120 bits (301), Expect = 6e-27
Identities = 90/293 (30%), Positives = 135/293 (46%), Gaps = 2/293 (0%)
Query: 26 LTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWEL 85
L + +P F L LE+L ++G+ ++ FS L SL L L N L +P L
Sbjct: 85 LCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHL 144
Query: 86 PSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNR 145
+L+SL L N + +P R F+ L+ L+ L L N L ++P + L +LQ + L+ N
Sbjct: 145 AALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNA 204
Query: 146 ISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAI-RTL 204
+S +P F L SL L L +N I L F L LE L L N + P++I +L
Sbjct: 205 LSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASL 264
Query: 205 GRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN-GA 263
G L L N ++ +P F P L + N ++ V F +L L +L L+ A
Sbjct: 265 GNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNA 324
Query: 264 MDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP 316
+ + L L L + L + Q L +L +L LS NQ+ LP
Sbjct: 325 ITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLP 377
Score = 119 bits (297), Expect = 2e-26
Identities = 85/267 (31%), Positives = 126/267 (47%), Gaps = 25/267 (9%)
Query: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
L+ N L L GLF HL LE L L GN L +P + F L LK L L N L +P E
Sbjct: 128 LNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEE 187
Query: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
L SLQ+L+L N +S +P+ F L SL+ L+LD N ++E+P + + L L+ +
Sbjct: 188 LFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLW 247
Query: 141 LALNRISHIPDYAFQNLTS------------------------LVVLHLHNNRIQHLGTH 176
L N I+H+P F +L + LV L L +N+++ +
Sbjct: 248 LQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEG 307
Query: 177 SFEGLHNLETLDLNYNKLQEFPVAI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 235
+F L NL +L L+YN + P I R L L +L +NN+ A+ F L+ +
Sbjct: 308 TFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLS 367
Query: 236 FYDNPIQFVGRSAFQYLPKLHTLSLNG 262
N + + F L L+L+G
Sbjct: 368 LSKNQLTTLPEGIFDTNYNLFNLALHG 394
Score = 95.5 bits (236), Expect = 2e-19
Identities = 63/175 (36%), Positives = 89/175 (50%)
Query: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
L NN++EL P +F L LE L L N ++H+P F+ L +L L LQ N L +PA
Sbjct: 224 LDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAG 283
Query: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
P L L L N + V E +F LS+LR L L NA+T +P +L L +
Sbjct: 284 LFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLY 343
Query: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
L N ++ + FQNL+ L +L L N++ L F+ +NL L L+ N Q
Sbjct: 344 LGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQ 398
Score = 74.3 bits (181), Expect = 5e-13
Identities = 64/221 (28%), Positives = 92/221 (41%), Gaps = 30/221 (13%)
Query: 212 FHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD 271
F + + +AF NP L + F + + AF LP+L L + G+ + +
Sbjct: 56 FVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTN 115
Query: 272 L-KGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS------------- 317
+ TSL LTL + LP G+ Q L L L L NQ++ LP
Sbjct: 116 IFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLN 175
Query: 318 -------------LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 364
H L+ + L +N + + F +L SLQ L L N I + P+
Sbjct: 176 LAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQ 235
Query: 365 AFSTLHSLVKLDLTDNQLTTLPL---AGLGGLMHLKLKGNL 402
FS L L +L L N +T LPL A LG L L L+ N+
Sbjct: 236 VFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNM 276
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 126 bits (316), Expect = 1e-28
Identities = 114/372 (30%), Positives = 170/372 (45%), Gaps = 39/372 (10%)
Query: 38 RFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANL 97
R E L L+GN+++ I F+GL L++L L N++ I A +L L+ LRL+ N
Sbjct: 55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNH 114
Query: 98 ISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNL 157
+ L PE F G + L L L +N + IP +A ++ + L N+IS I D AF+ L
Sbjct: 115 LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRAL 174
Query: 158 TSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL--------------QEFPVAIRT 203
L VL L+NN I L SF + L T L+ N L Q V + T
Sbjct: 175 RDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYT 234
Query: 204 LGRLQELG---FHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRS-AFQYLPKLHTLS 259
Q +G +N+ + ++ F+ F+ S + + P T S
Sbjct: 235 ----QCMGPSHLRGHNVAEVQKREFV----------CSGHQSFMAPSCSVLHCPAACTCS 280
Query: 260 LN----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 315
N + E P T EI L + I+++P G +LR ++LS+NQI EL
Sbjct: 281 NNIVDCRGKGLTEIPTNLPETITEI-RLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISEL 339
Query: 316 --PSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLV 373
+ + L + L N+I E+ F L SLQ L L+ N I + +AF LH+L
Sbjct: 340 APDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLN 399
Query: 374 KLDLTDNQLTTL 385
L L DN+L T+
Sbjct: 400 LLSLYDNKLQTI 411
Score = 99.4 bits (246), Expect = 1e-20
Identities = 96/342 (28%), Positives = 156/342 (45%), Gaps = 27/342 (7%)
Query: 67 LMLQNNQLGGIPAEALWE-LPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEI 125
L L NN+ + A +++ LP L+ + N I+ + E +FEG S + + L N L +
Sbjct: 538 LRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENV 597
Query: 126 PVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLE 185
+ L +L+ + L NRI+ + + +F L+S+ +L L++N+I + +F+ LH+L
Sbjct: 598 QHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLS 657
Query: 186 TLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFY-DNPIQFV 244
TL+L N + LG ++ GNP Q +F + PIQ V
Sbjct: 658 TLNLLANPF-NCNCYLAWLGEWLR-----------KKRIVTGNPRCQKPYFLKEIPIQDV 705
Query: 245 GRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPR-LR 303
A Q N + P + T ++ + G+++LP G +PR +
Sbjct: 706 ---AIQDFTCDDGNDDNSCSPLSRCP-TECTCLDTVVRCSNKGLKVLPKG----IPRDVT 757
Query: 304 VLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIH 362
L L NQ +P L + L I L +NRI + +FS ++ L L LS+N +R I
Sbjct: 758 ELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIP 817
Query: 363 PEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 401
P F L SL L L N ++ +P L L HL + N
Sbjct: 818 PRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGAN 859
Score = 96.7 bits (239), Expect = 9e-20
Identities = 100/370 (27%), Positives = 152/370 (41%), Gaps = 59/370 (15%)
Query: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
L N ++ ++ G F L+ LE LRL+ NHL P F G L L L NQ+ IP +
Sbjct: 86 LMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRK 145
Query: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
A +++L+LD N IS + + +F L L L L++N +T + V + N++P L+
Sbjct: 146 AFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFR 205
Query: 141 LALN------RISHIPDYAFQN------LTSLVVLHLHNNRIQHL--------GTHSFEG 180
L N ++ + D+ Q + HL + + + G SF
Sbjct: 206 LHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMA 265
Query: 181 -----LH-------NLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGN 228
LH + +D L E P + + E+ N IK IP AF
Sbjct: 266 PSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE--TITEIRLEQNTIKVIPPGAFSPY 323
Query: 229 PLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRA 286
L+ I +N I + AFQ L L++L L G I E P +G SL++L L
Sbjct: 324 KKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYG-NKITELPKSLFEGLFSLQLLLLNAN 382
Query: 287 GIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLS 346
I L Q L L +L L N+++ I TFS L
Sbjct: 383 KINCLRVDAFQDLHNLNLLSLYDNKLQ----------------------TIAKGTFSPLR 420
Query: 347 SLQALDLSWN 356
++Q + L+ N
Sbjct: 421 AIQTMHLAQN 430
Score = 87.0 bits (214), Expect = 7e-17
Identities = 104/384 (27%), Positives = 156/384 (40%), Gaps = 72/384 (18%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
DLS N ++EL P F LR L L L GN ++ +P F GL+SL++L+L N++ +
Sbjct: 330 DLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRV 389
Query: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLR--HL------------WLDDNALTEI 125
+A +L +L L L N + + + +F L +++ HL WL D T
Sbjct: 390 DAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTN- 448
Query: 126 PVRALNNLPALQAMTLALNRISHIPDYAFQ-NLTSLVVLHLHNNRIQHLGTHSFEGLHNL 184
P+ + LA RI I F+ + + + L F L
Sbjct: 449 PIET-SGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACP 507
Query: 185 E-------TLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKA-FMGNPLLQTIHF 236
E T+D + KL + P I EL +NN + F P L+ I+F
Sbjct: 508 EKCRCEGTTVDCSNQKLNKIPEHIPQY--TAELRLNNNEFTVLEATGIFKKLPQLRKINF 565
Query: 237 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 296
+N I + AF+ GA + E LL S
Sbjct: 566 SNNKITDIEEGAFE-----------GASGVNEI--------------------LLTSN-- 592
Query: 297 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 356
R+ + H + L SL + + L+ NRI +G D+F LSS++ L L N
Sbjct: 593 ------RLENVQHKMFKGLESL------KTLMLRSNRITCVGNDSFIGLSSVRLLSLYDN 640
Query: 357 AIRSIHPEAFSTLHSLVKLDLTDN 380
I ++ P AF TLHSL L+L N
Sbjct: 641 QITTVAPGAFDTLHSLSTLNLLAN 664
Score = 77.4 bits (189), Expect = 6e-14
Identities = 87/384 (22%), Positives = 149/384 (38%), Gaps = 85/384 (22%)
Query: 71 NNQLGGIPAEALWELPS-----LQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEI 125
+N + + L E+P+ + +RL+ N I ++P +F LR + L +N ++E+
Sbjct: 280 SNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISEL 339
Query: 126 PVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLE 185
A L +L ++ L N+I+ +P F+ L SL +L L+ N+I L +F+ LHNL
Sbjct: 340 APDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLN 399
Query: 186 TLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG 245
L L NKLQ I + F +QT+H NP F+
Sbjct: 400 LLSLYDNKLQ-----------------------TIAKGTFSPLRAIQTMHLAQNP--FIC 434
Query: 246 RSAFQYLPK-LHTLSLN------------------------------------GAMDIQE 268
++L LHT + G D +
Sbjct: 435 DCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRS 494
Query: 269 ------FPDL--------KGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEE 314
F DL +GTT + + + +P + Q LR+ +E
Sbjct: 495 KLSGDCFADLACPEKCRCEGTT----VDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEA 550
Query: 315 LPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVK 374
+ +L +I +N+I +I F S + + L+ N + ++ + F L SL
Sbjct: 551 TGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKT 610
Query: 375 LDLTDNQLTTLPLAGLGGLMHLKL 398
L L N++T + GL ++L
Sbjct: 611 LMLRSNRITCVGNDSFIGLSSVRL 634
Score = 57.8 bits (138), Expect = 5e-08
Identities = 34/107 (31%), Positives = 57/107 (53%), Gaps = 1/107 (0%)
Query: 38 RFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANL 97
R + EL L GN + +P + S L ++ L NN++ + ++ + L +L L N
Sbjct: 754 RDVTELYLDGNQFTLVPKE-LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNR 812
Query: 98 ISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALN 144
+ +P R+F+GL SLR L L N ++ +P A N+L AL + + N
Sbjct: 813 LRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGAN 859
Score = 56.2 bits (134), Expect = 1e-07
Identities = 37/98 (37%), Positives = 51/98 (52%)
Query: 25 NLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWE 84
N L P + + L + LS N +S + Q+FS + L L+L N+L IP
Sbjct: 764 NQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDG 823
Query: 85 LPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNAL 122
L SL+ L L N IS+VPE +F LS+L HL + N L
Sbjct: 824 LKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPL 861
Score = 50.8 bits (120), Expect = 6e-06
Identities = 36/107 (33%), Positives = 54/107 (50%), Gaps = 7/107 (6%)
Query: 91 LRLDANLISLVPERSFEGLSSLRHLWLDD---NALTEIPVRALNNLPALQAMTLALNRIS 147
L LD N +LVP+ LS+ +HL L D N ++ + ++ +N+ L + L+ NR+
Sbjct: 759 LYLDGNQFTLVPKE----LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLR 814
Query: 148 HIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 194
IP F L SL +L LH N I + +F L L L + N L
Sbjct: 815 CIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPL 861
Score = 47.8 bits (112), Expect = 5e-05
Identities = 29/77 (37%), Positives = 41/77 (53%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
DLS N ++ L F ++ L L LS N L IP + F GL SL++L L N + +P
Sbjct: 783 DLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPE 842
Query: 80 EALWELPSLQSLRLDAN 96
A +L +L L + AN
Sbjct: 843 GAFNDLSALSHLAIGAN 859
Score = 37.7 bits (86), Expect = 0.049
Identities = 34/123 (27%), Positives = 52/123 (42%), Gaps = 9/123 (7%)
Query: 305 LELSHNQIEELPSLHRC--QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIH 362
L+L+ N I + + L + L N+I I F L L+ L L+ N ++
Sbjct: 60 LDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFP 119
Query: 363 PEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALS----QAFSKDSFPKLRI 418
F L +LDL++NQ+ +P G + +K NL L +F LR
Sbjct: 120 ELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIK---NLQLDYNQISCIEDGAFRALRD 176
Query: 419 LEV 421
LEV
Sbjct: 177 LEV 179
Score = 33.5 bits (75), Expect = 0.93
Identities = 21/54 (38%), Positives = 28/54 (51%)
Query: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 74
LS N L + P F L+ L L L GN +S +P AF+ L +L L + N L
Sbjct: 808 LSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPL 861
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 125 bits (313), Expect = 2e-28
Identities = 115/378 (30%), Positives = 186/378 (49%), Gaps = 18/378 (4%)
Query: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75
IS DLS N L+ ++ HL+ L E++L+ N L IP ++ +L L N++
Sbjct: 16 ISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA-NITLLSLAGNRIV 74
Query: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP- 134
I E L E SL++L L +N IS + + +F L L++L+L+ N +T + +NL
Sbjct: 75 EILPEHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LKYLYLNSNRVTSMEPGYFDNLAN 132
Query: 135 ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 194
L + L NRIS IP F+ L L L L+ N+I+++ +F+GL L++L + N +
Sbjct: 133 TLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGV 191
Query: 195 QEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLP 253
+ A L ++ L +NN+ I + G +LQ +H N I + A+++
Sbjct: 192 TKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ 251
Query: 254 KLHTLSLN----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSH 309
KL L L +D F G + L L + + + + L L+ L+L +
Sbjct: 252 KLSELDLTFNHLSRLDDSSF---LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKN 308
Query: 310 NQI----EELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 364
N+I E++ + KL + LQ NRI I F+ L +L+ LDLS NAI S+
Sbjct: 309 NEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN 368
Query: 365 AFSTLHSLVKLDLTDNQL 382
AFS + L +L L + L
Sbjct: 369 AFSQMKKLQQLHLNTSSL 386
Score = 85.5 bits (210), Expect = 2e-16
Identities = 81/294 (27%), Positives = 138/294 (46%), Gaps = 14/294 (4%)
Query: 117 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 176
L N L+ I ++++L +L+ + L N + IP+ + ++ +L L NRI +
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIVEILPE 79
Query: 177 SFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAF--MGNPLLQTI 234
+ +LETLDL+ N + E A L +L+ L ++N + ++ F + N LL +
Sbjct: 80 HLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLL-VL 137
Query: 235 HFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDL--KGTTSLEILTLTRAGIRLLP 292
N I + F+ LP+L L LN I+ L +G +L+ L + R G+ L
Sbjct: 138 KLNRNRISAIPPKMFK-LPQLQHLELN-RNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195
Query: 293 SGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQA 350
G L + +L+L HN + E+ L+ L+E+ L N I I D + L
Sbjct: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255
Query: 351 LDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGN 401
LDL++N + + +F L L L + +N+++ + GL L L LK N
Sbjct: 256 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 309
Score = 73.6 bits (179), Expect = 8e-13
Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 3/160 (1%)
Query: 14 IIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 73
+++ LS N + + P + + L EL L+ NHLS + +F GL L L + NN+
Sbjct: 227 LMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNR 286
Query: 74 LGGIPAEALWELPSLQSLRLDANLISLVPE---RSFEGLSSLRHLWLDDNALTEIPVRAL 130
+ I A L SL++L L N IS E +F GL LR L L N + I +A
Sbjct: 287 VSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAF 346
Query: 131 NNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRI 170
L AL+ + L+ N I + AF + L LHL+ + +
Sbjct: 347 TGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386
Score = 57.4 bits (137), Expect = 6e-08
Identities = 66/245 (26%), Positives = 109/245 (44%), Gaps = 32/245 (13%)
Query: 165 LHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKA 224
L +NR+ + S L +L + LN N+L+ P LG + NI + +
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP----------NLGPVSANITLL---S 67
Query: 225 FMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE-FPDLKGTTSLEILTL 283
GN +++ + + FQ L L LS N ++Q FP L+ L+ L L
Sbjct: 68 LAGNRIVEILPEH--------LKEFQSLETLD-LSSNNISELQTAFPALQ----LKYLYL 114
Query: 284 TRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADT 341
+ + G L L VL+L+ N+I +P + + +L+ + L N+I + T
Sbjct: 115 NSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLT 174
Query: 342 FSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 401
F L +L++L + N + + AF L ++ L L N LT + L GL+ L+
Sbjct: 175 FQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQ---E 231
Query: 402 LALSQ 406
L LSQ
Sbjct: 232 LHLSQ 236
>gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo
sapiens]
Length = 754
Score = 124 bits (310), Expect = 5e-28
Identities = 153/633 (24%), Positives = 270/633 (42%), Gaps = 89/633 (14%)
Query: 182 HNLETLDLNYNKLQEFPVAIRT-LGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNP 240
+N+ L L NK+ P + +L+++ +N I+ I KAF G LQ ++ N
Sbjct: 137 NNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNC 196
Query: 241 IQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDL-KGTTSLEILTLTRAGIRLLPSGMCQQL 299
I + F+ L +L L L+ + L G SL L++ + LP MC Q+
Sbjct: 197 ITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQM 256
Query: 300 PRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIR 359
P+L ++L N+I+ L + TF SL L L N I
Sbjct: 257 PQLNWVDLEGNRIKYLTN----------------------STFLSCDSLTVLFLPRNQIG 294
Query: 360 SIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRIL 419
+ + FS+L +L +LDL+ N +T L L +L L Q KL +
Sbjct: 295 FVPEKTFSSLKNLGELDLSSNTITELSP---------HLFKDLKLLQ--------KLNLS 337
Query: 420 EVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQ 479
P Y + + F++ Q ++ DL + + + + + Y ++
Sbjct: 338 SNPLMY------LHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCS 391
Query: 480 LEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVL---LTVFA 536
PH + C P E L + +R+ VW I ++ N V+ + A
Sbjct: 392 YA-----PHVRI-CMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKA 445
Query: 537 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 596
+K + A+ L G+ + D GQ+ +Y W + CR GFL
Sbjct: 446 ENTTHAMSIKI----LCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFL 501
Query: 597 AVLGSEASVLLLTLAAVQCSVSV----SCVRAYGKSPSLGSVRAGVLGCLALAG-LAAAL 651
A+L +E SVLLLT ++ + + S +R + S+ +L C+ +AG L A +
Sbjct: 502 AMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSV------ILICIWMAGFLIAVI 555
Query: 652 PLASV----GEYGASPLCLP-YAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCD 705
P + YG + +C P Y + G+++ + + +N FL++ +YI ++C
Sbjct: 556 PFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCS 615
Query: 706 LPRGDFEA--VWDC-----AMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPV-TPEAVK 757
+ + + V +C A+ +++F+D + + PV + +L LF V P+ +
Sbjct: 616 IQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVV---KILSLFRVEIPDTMT 672
Query: 758 S-VLLVVLPLPACLNPLLYLLFNPHFRDDLRRL 789
S +++ LP+ + LNP+LY L F+D L++L
Sbjct: 673 SWIVIFFLPVNSALNPILYTLTTNFFKDKLKQL 705
Score = 93.6 bits (231), Expect = 8e-19
Identities = 74/251 (29%), Positives = 119/251 (47%), Gaps = 1/251 (0%)
Query: 6 LTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLK 65
L V +S ++ L N + L +F L+++ L N + HI +AF GL +L+
Sbjct: 129 LKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQ 188
Query: 66 ILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEI 125
IL L +N + + +L L L LD N I+ + +R F GL+SL L + +N L +
Sbjct: 189 ILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEAL 248
Query: 126 PVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLE 185
P + +P L + L NRI ++ + F + SL VL L N+I + +F L NL
Sbjct: 249 PKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLG 308
Query: 186 TLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFV 244
LDL+ N + E P + L LQ+L +N + + + F LQ++ I +
Sbjct: 309 ELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNI 368
Query: 245 GRSAFQYLPKL 255
FQ + L
Sbjct: 369 NTRMFQPMKNL 379
Score = 43.5 bits (101), Expect = 9e-04
Identities = 24/72 (33%), Positives = 37/72 (51%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
DLS N +TEL P LF L+ L++L LS N L ++ F L L+ L L+ ++ I
Sbjct: 311 DLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINT 370
Query: 80 EALWELPSLQSL 91
+ +L +
Sbjct: 371 RMFQPMKNLSHI 382
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 123 bits (309), Expect = 7e-28
Identities = 113/378 (29%), Positives = 186/378 (49%), Gaps = 18/378 (4%)
Query: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75
++ DLS N L+ ++ HL+ L E++L+ N L IP ++ +L L N++
Sbjct: 76 VARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA-NITLLSLAGNRIV 134
Query: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP- 134
I E L E SL++L L +N IS + + +F L L++L+L+ N +T + +NL
Sbjct: 135 EILPEHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LKYLYLNSNRVTSMEPGYFDNLAN 192
Query: 135 ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 194
L + L NRIS IP F+ L L L L+ N+I+++ +F+GL L++L + N +
Sbjct: 193 TLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGV 251
Query: 195 QEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLP 253
+ A L ++ L +NN+ I + G +LQ +H N I + A+++
Sbjct: 252 TKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ 311
Query: 254 KLHTLSLN----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSH 309
KL L L +D F G + L L + + + + L L+ L+L +
Sbjct: 312 KLSELDLTFNHLSRLDDSSF---LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKN 368
Query: 310 NQI----EELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 364
N+I E++ + KL + LQ NRI I F+ L +L+ LDLS NAI S+
Sbjct: 369 NEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN 428
Query: 365 AFSTLHSLVKLDLTDNQL 382
AFS + L +L L + L
Sbjct: 429 AFSQMKKLQQLHLNTSSL 446
Score = 85.9 bits (211), Expect = 2e-16
Identities = 83/301 (27%), Positives = 141/301 (46%), Gaps = 14/301 (4%)
Query: 110 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR 169
S + L L N L+ I ++++L +L+ + L N + IP+ + ++ +L L NR
Sbjct: 74 SWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNR 132
Query: 170 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAF--MG 227
I + + +LETLDL+ N + E A L +L+ L ++N + ++ F +
Sbjct: 133 IVEILPEHLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLA 191
Query: 228 NPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDL--KGTTSLEILTLTR 285
N LL + N I + F+ LP+L L LN I+ L +G +L+ L + R
Sbjct: 192 NTLL-VLKLNRNRISAIPPKMFK-LPQLQHLELN-RNKIKNVDGLTFQGLGALKSLKMQR 248
Query: 286 AGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFS 343
G+ L G L + +L+L HN + E+ L+ L+E+ L N I I D +
Sbjct: 249 NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWE 308
Query: 344 QLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKG 400
L LDL++N + + +F L L L + +N+++ + GL L L LK
Sbjct: 309 FCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKN 368
Query: 401 N 401
N
Sbjct: 369 N 369
Score = 73.6 bits (179), Expect = 8e-13
Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 3/160 (1%)
Query: 14 IIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 73
+++ LS N + + P + + L EL L+ NHLS + +F GL L L + NN+
Sbjct: 287 LMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNR 346
Query: 74 LGGIPAEALWELPSLQSLRLDANLISLVPE---RSFEGLSSLRHLWLDDNALTEIPVRAL 130
+ I A L SL++L L N IS E +F GL LR L L N + I +A
Sbjct: 347 VSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAF 406
Query: 131 NNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRI 170
L AL+ + L+ N I + AF + L LHL+ + +
Sbjct: 407 TGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
Score = 58.5 bits (140), Expect = 3e-08
Identities = 67/247 (27%), Positives = 110/247 (44%), Gaps = 32/247 (12%)
Query: 163 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPE 222
L L +NR+ + S L +L + LN N+L+ P LG + NI +
Sbjct: 79 LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP----------NLGPVSANITLL-- 126
Query: 223 KAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE-FPDLKGTTSLEIL 281
+ GN +++ + + FQ L L LS N ++Q FP L+ L+ L
Sbjct: 127 -SLAGNRIVEILPEH--------LKEFQSLETLD-LSSNNISELQTAFPALQ----LKYL 172
Query: 282 TLTRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGA 339
L + + G L L VL+L+ N+I +P + + +L+ + L N+I +
Sbjct: 173 YLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDG 232
Query: 340 DTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLK 399
TF L +L++L + N + + AF L ++ L L N LT + L GL+ L+
Sbjct: 233 LTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQ-- 290
Query: 400 GNLALSQ 406
L LSQ
Sbjct: 291 -ELHLSQ 296
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 122 bits (307), Expect = 1e-27
Identities = 108/371 (29%), Positives = 175/371 (47%), Gaps = 34/371 (9%)
Query: 38 RFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANL 97
R E L L+GN+++ I F+GL L++L L NQ+G + A ++ L+ LRL+ N
Sbjct: 61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 120
Query: 98 ISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNL 157
+ ++PE F+ +L L L +NA+ IP +A L+ + L N+IS I + AF+ L
Sbjct: 121 LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL 180
Query: 158 TSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK---------LQEFPVAIRTLGRLQ 208
L VL L+NN I + SF + L T L+ N L ++ T+G
Sbjct: 181 RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFT 240
Query: 209 E----LGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAM 264
+ N+ + + F + + P + + P + T S NG +
Sbjct: 241 QCSGPASLRGLNVAEVQKSEFSCSGQGEAGRV---PTCTLSSGS---CPAMCTCS-NGIV 293
Query: 265 DIQEFPDLKGTTSL-----EILTLTRA---GIRLLPSGMCQQLPRLRVLELSHNQIEEL- 315
D + KG T++ E +T R GI+ +P G +LR ++LS+NQI E+
Sbjct: 294 DCRG----KGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIA 349
Query: 316 -PSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVK 374
+ + L + L N+I ++ F L +LQ L L+ N I I P+AF L +L
Sbjct: 350 PDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSL 409
Query: 375 LDLTDNQLTTL 385
L L DN++ +L
Sbjct: 410 LSLYDNKIQSL 420
Score = 106 bits (265), Expect = 9e-23
Identities = 96/331 (29%), Positives = 149/331 (45%), Gaps = 30/331 (9%)
Query: 89 QSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISH 148
+ L L+ N I+ + + F GL LR L L +N + + A +++ L+ + L N++
Sbjct: 64 ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHM 123
Query: 149 IPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AIRTLGRL 207
+P+ FQN +L L L N IQ + +F G +L+ L L+ N++ A R L L
Sbjct: 124 LPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGL 183
Query: 208 QELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAF--QYLPKLHTLSLNGAMD 265
+ L +NNNI IP +F P L+T + N + A+ Q+L + T+ L
Sbjct: 184 EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGL----- 238
Query: 266 IQEFPDLKGTTSLEILTLT----------------RAGIRLLPSGMCQQLPRLR--VLEL 307
F G SL L + R L SG C + +++
Sbjct: 239 ---FTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDC 295
Query: 308 SHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFS 367
+ +P+ + + + EI L+ N I I FS L+ +DLS N I I P+AF
Sbjct: 296 RGKGLTAIPA-NLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQ 354
Query: 368 TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKL 398
L SL L L N++T LP GGL L+L
Sbjct: 355 GLRSLNSLVLYGNKITDLPRGVFGGLYTLQL 385
Score = 94.7 bits (234), Expect = 3e-19
Identities = 128/513 (24%), Positives = 195/513 (38%), Gaps = 105/513 (20%)
Query: 8 LVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKIL 67
L+ Q + +S DLS N + + F L+ L+L N +S I AF L L++L
Sbjct: 127 LLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVL 186
Query: 68 MLQNNQLGGIPAEALWELPSLQSLRLDAN----------LISLVPERSFEGL-------S 110
L NN + IP + +P L++ RL +N L + +R GL +
Sbjct: 187 TLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPA 246
Query: 111 SLRHLWLDD----------------------------------NALTEIPVRALNNLPA- 135
SLR L + + N + + + L +PA
Sbjct: 247 SLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPAN 306
Query: 136 ----LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNY 191
+ + L LN I IP AF L + L NN+I + +F+GL +L +L L
Sbjct: 307 LPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYG 366
Query: 192 NKLQEFPVAI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQ 250
NK+ + P + L LQ L + N I I AF L + YDN IQ + + F
Sbjct: 367 NKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFT 426
Query: 251 YLPKLHTLSLNG-----AMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQ------- 298
L + TL L +++ D T +E A R L + Q
Sbjct: 427 SLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFR 486
Query: 299 --------LPRLRVLELSHNQIEELPSLHRC----------------------QKLEEIG 328
+P +L+ ++ H+C Q E+
Sbjct: 487 CSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELR 546
Query: 329 LQHNRIWEIGA-DTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL-- 385
L +N I + A F +L+ L+ ++LS N + I AF S+ +L LT NQL ++
Sbjct: 547 LNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRS 606
Query: 386 -PLAGLGGLMHLKLKGNLALSQAFSKDSFPKLR 417
GL GL L L+ N DSF LR
Sbjct: 607 GMFRGLDGLRTLMLRNNRI--SCIHNDSFTGLR 637
Score = 94.7 bits (234), Expect = 3e-19
Identities = 105/392 (26%), Positives = 163/392 (41%), Gaps = 60/392 (15%)
Query: 40 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLIS 99
+ E+RL N + IP AFS L+ + L NNQ+ I +A
Sbjct: 311 MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDA------------------ 352
Query: 100 LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTS 159
F+GL SL L L N +T++P L LQ + L N+I+ I AFQ+L +
Sbjct: 353 ------FQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQN 406
Query: 160 LVVLHLHNNRIQHLGTHSFEGLHNLETL---------DLNYNKLQEF----PVAIRTLGR 206
L +L L++N+IQ L +F L ++TL D N L +F P+
Sbjct: 407 LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARC 466
Query: 207 LQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT-----LSLN 261
N I I K F + Q Y P G +Q + ++
Sbjct: 467 ASPRRLANKRIGQIKSKKFRCSAKEQ----YFIP----GTEDYQLNSECNSDVVCPHKCR 518
Query: 262 GAMDIQEFPDLKGTTSLEILTLTRAGIR--------LLPSGMCQQLPRLRVLELSHNQIE 313
++ E LK T E + + A +R L +GM ++L L+ + LS+N++
Sbjct: 519 CEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVS 578
Query: 314 ELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHS 371
E+ + + E+ L N++ I + F L L+ L L N I IH ++F+ L +
Sbjct: 579 EIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRN 638
Query: 372 LVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLA 403
+ L L DNQ+TT+ L L LA
Sbjct: 639 VRLLSLYDNQITTVSPGAFDTLQSLSTLNLLA 670
Score = 91.3 bits (225), Expect = 4e-18
Identities = 94/341 (27%), Positives = 152/341 (44%), Gaps = 25/341 (7%)
Query: 67 LMLQNNQLGGIPAEALWE-LPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEI 125
L L NN++ + A +++ L L+ + L N +S + + +FEG +S+ L L N L I
Sbjct: 545 LRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESI 604
Query: 126 PVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLE 185
L L+ + L NRIS I + +F L ++ +L L++N+I + +F+ L +L
Sbjct: 605 RSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLS 664
Query: 186 TLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDN-PIQFV 244
TL+L N G L++ K GNP Q F P+Q V
Sbjct: 665 TLNLLANPFNCNCQLAWLGGWLRK------------RKIVTGNPRCQNPDFLRQIPLQDV 712
Query: 245 GRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRV 304
AF G + + P ++ + +R LP G+ + + L
Sbjct: 713 ---AFPDFRCEEGQEEGGCLPRPQCPQECACLDT-VVRCSNKHLRALPKGIPKNVTELY- 767
Query: 305 LELSHNQIEELPS-LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHP 363
L NQ +P L + L+ + L +N+I + +F+ +S L L LS+NA++ I P
Sbjct: 768 --LDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPP 825
Query: 364 EAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 401
AF L SL L L N ++TL A + L HL + N
Sbjct: 826 LAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGAN 866
Score = 88.6 bits (218), Expect = 2e-17
Identities = 115/444 (25%), Positives = 177/444 (39%), Gaps = 56/444 (12%)
Query: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
L +N + + PG F R L + LS N ++ I AF GL SL L+L N++ +P
Sbjct: 316 LELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRG 375
Query: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
L +LQ L L+AN I+ + +F+ L +L L L DN + + +L A+Q +
Sbjct: 376 VFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLH 435
Query: 141 LALN------RISHIPDYAFQN------LTSLVVLHLHNNRIQHLGTHSFE-------GL 181
LA N + + D+ N L N RI + + F +
Sbjct: 436 LAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFI 495
Query: 182 HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 241
E LN + + + + + IPE+ L+ +N I
Sbjct: 496 PGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELR---LNNNEI 552
Query: 242 QFV-GRSAFQYLPKLHTLSL-NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQL 299
+ F+ L L ++L N + E +G S+ L LT + + SGM + L
Sbjct: 553 SILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGL 612
Query: 300 PRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIR 359
LR L L +N+I + HN D+F+ L +++ L L N I
Sbjct: 613 DGLRTLMLRNNRISCI---------------HN-------DSFTGLRNVRLLSLYDNQIT 650
Query: 360 SIHPEAFSTLHSLVKLDLTDNQLT-TLPLAGLGGLMHLK--LKGNLA------LSQAFSK 410
++ P AF TL SL L+L N LA LGG + + + GN L Q +
Sbjct: 651 TVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQ 710
Query: 411 D-SFPKLRILEVPYAYQCCPYGMC 433
D +FP R E C P C
Sbjct: 711 DVAFPDFRCEEGQEEGGCLPRPQC 734
Score = 61.6 bits (148), Expect = 3e-09
Identities = 52/183 (28%), Positives = 74/183 (40%), Gaps = 25/183 (13%)
Query: 132 NLPA-LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLN 190
N+P + + L N I+ I F L L VL L N+I + +F+ + LE L LN
Sbjct: 58 NIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLN 117
Query: 191 YNKLQEFP-VAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAF 249
N+L P + + L L N I+AIP KAF G L+ + N I + AF
Sbjct: 118 RNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAF 177
Query: 250 QYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSH 309
+ L LE+LTL I +P +P+LR L
Sbjct: 178 RAL-----------------------RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHS 214
Query: 310 NQI 312
N +
Sbjct: 215 NHL 217
Score = 56.6 bits (135), Expect = 1e-07
Identities = 66/257 (25%), Positives = 109/257 (42%), Gaps = 16/257 (6%)
Query: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75
+S L+ N L ++ G+F L L L L N +S I +F+GL ++++L L +NQ+
Sbjct: 591 VSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQIT 650
Query: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 135
+ A L SL +L L AN + + ++ G + + N + P L +P
Sbjct: 651 TVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNP-DFLRQIP- 708
Query: 136 LQAMTLALNRISH---------IPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGL-HNLE 185
LQ + R P + V+ N ++ L +G+ N+
Sbjct: 709 LQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALP----KGIPKNVT 764
Query: 186 TLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG 245
L L+ N+ P + T LQ + NN I ++ +F L T+ N +Q +
Sbjct: 765 ELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIP 824
Query: 246 RSAFQYLPKLHTLSLNG 262
AFQ L L LSL+G
Sbjct: 825 PLAFQGLRSLRLLSLHG 841
Score = 53.9 bits (128), Expect = 7e-07
Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 24/125 (19%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
+LS N ++E++ G F + EL L+ N L I F GL L+ LML+NN+
Sbjct: 571 NLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNR------ 624
Query: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
IS + SF GL ++R L L DN +T + A + L +L +
Sbjct: 625 ------------------ISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTL 666
Query: 140 TLALN 144
L N
Sbjct: 667 NLLAN 671
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/111 (32%), Positives = 55/111 (49%), Gaps = 7/111 (6%)
Query: 87 SLQSLRLDANLISLVPERSFEGLSSLRHLWLDD---NALTEIPVRALNNLPALQAMTLAL 143
++ L LD N +LVP + LS+ ++L L D N ++ + + N+ L + L+
Sbjct: 762 NVTELYLDGNQFTLVPGQ----LSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSY 817
Query: 144 NRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 194
N + IP AFQ L SL +L LH N I L F + +L L + N L
Sbjct: 818 NALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868
Score = 49.7 bits (117), Expect = 1e-05
Identities = 29/103 (28%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Query: 42 ELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLV 101
EL L GN + +PGQ + Y L+++ L NN++ + + + L +L L N + +
Sbjct: 765 ELYLDGNQFTLVPGQLSTFKY-LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCI 823
Query: 102 PERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALN 144
P +F+GL SLR L L N ++ + ++ +L + + N
Sbjct: 824 PPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGAN 866
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/136 (29%), Positives = 62/136 (45%), Gaps = 6/136 (4%)
Query: 299 LPRLRVLELSHNQIE--ELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 356
L +LRVL+L NQI E + ++LE + L N++ + F +L LDLS N
Sbjct: 84 LKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSEN 143
Query: 357 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKL----KGNLALSQAFSKDS 412
AI++I +AF L L L NQ++ + L L++ N+ S +
Sbjct: 144 AIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNH 203
Query: 413 FPKLRILEVPYAYQCC 428
PKLR + + C
Sbjct: 204 MPKLRTFRLHSNHLFC 219
Score = 45.1 bits (105), Expect = 3e-04
Identities = 29/83 (34%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
Query: 160 LVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP-VAIRTLGRLQELGFHNNNIK 218
L ++ L NN+I L SF + L TL L+YN LQ P +A + L L+ L H N+I
Sbjct: 786 LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIS 845
Query: 219 AIPEKAFMGNPLLQTIHFYDNPI 241
+ E F L + NP+
Sbjct: 846 TLQEGIFADVTSLSHLAIGANPL 868
Score = 44.7 bits (104), Expect = 4e-04
Identities = 28/77 (36%), Positives = 39/77 (50%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
DLS N ++ L F ++ L L LS N L IP AF GL SL++L L N + +
Sbjct: 790 DLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQE 849
Query: 80 EALWELPSLQSLRLDAN 96
++ SL L + AN
Sbjct: 850 GIFADVTSLSHLAIGAN 866
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 122 bits (305), Expect = 2e-27
Identities = 119/394 (30%), Positives = 175/394 (44%), Gaps = 48/394 (12%)
Query: 41 EELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISL 100
+ L G L+ +PG S SL L N+L I +LP+LQ + L+ N ++
Sbjct: 50 DSLDCGGRGLAALPGDLPSWTRSLN---LSYNKLSEIDPAGFEDLPNLQEVYLNNNELTA 106
Query: 101 VPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSL 160
VP S + L+L N + + L +L+ + L+LN I+ + + F + +
Sbjct: 107 VPSLGAAS-SHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPI 165
Query: 161 VVLHLHNNRIQHLGTHSFEGL-HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKA 219
L+L NRI L +F+GL +L TL L+ N++ + PV L RL +L + N I+
Sbjct: 166 KELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRL 225
Query: 220 IPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL--NGAMDIQEFPDLKGTTS 277
I F G L+ + N I + AF L K+H L L N +++
Sbjct: 226 IEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVN---------- 275
Query: 278 LEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHR-----CQKLEEIGLQHN 332
SG L L L LS+N I + HR CQKL E+ L N
Sbjct: 276 ---------------SGSLYGLTALHQLHLSNNSIARI---HRKGWSFCQKLHELVLSFN 317
Query: 333 RIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL------TTLP 386
+ + ++ ++LSSL L LS N+I I AF L SL LDL N++ T+
Sbjct: 318 NLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGA 377
Query: 387 LAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILE 420
+GL L L L GN S A K +F L LE
Sbjct: 378 FSGLDSLSKLTLFGNKIKSVA--KRAFSGLEGLE 409
Score = 120 bits (301), Expect = 6e-27
Identities = 117/389 (30%), Positives = 171/389 (43%), Gaps = 39/389 (10%)
Query: 43 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 102
L LS N LS I F L +L+ + L NN+L +P+
Sbjct: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLG--------------------- 111
Query: 103 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVV 162
S + L+L N + + L +L+ + L+LN I+ + + F + +
Sbjct: 112 ----AASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKE 167
Query: 163 LHLHNNRIQHLGTHSFEGL-HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIP 221
L+L NRI L +F+GL +L TL L+ N++ + PV L RL +L + N I+ I
Sbjct: 168 LNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIE 227
Query: 222 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL--NGAMDIQEFPDLKGTTSLE 279
F G L+ + N I + AF L K+H L L N +++ L G T+L
Sbjct: 228 GLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNS-GSLYGLTALH 286
Query: 280 ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL--PSLHRCQKLEEIGLQHNRIWEI 337
L L+ I + +L L LS N + L SL L + L HN I I
Sbjct: 287 QLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHI 346
Query: 338 GADTFSQLSSLQALDLSWNAIRSIHPE---AFSTLHSLVKLDLTDNQLTTL---PLAGLG 391
F L SL+ LDL N I + AFS L SL KL L N++ ++ +GL
Sbjct: 347 AEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLE 406
Query: 392 GLMHLKLKGNLALSQAFSKDSFPKLRILE 420
GL HL L GN S F D+F K++ L+
Sbjct: 407 GLEHLNLGGNAIRSVQF--DAFVKMKNLK 433
Score = 112 bits (280), Expect = 2e-24
Identities = 75/245 (30%), Positives = 125/245 (51%), Gaps = 5/245 (2%)
Query: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
LS N +T+L F R L +L L+ N + I G F GL SL++L LQ N + +
Sbjct: 195 LSKNRITQLPVRAFKLPR-LTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDG 253
Query: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
A W L + L L+ N + V S GL++L L L +N++ I + + L +
Sbjct: 254 AFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELV 313
Query: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK----LQE 196
L+ N ++ + + + L+SL VL L +N I H+ +F+GL +L LDL++N+ +++
Sbjct: 314 LSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIED 373
Query: 197 FPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLH 256
A L L +L N IK++ ++AF G L+ ++ N I+ V AF + L
Sbjct: 374 TSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLK 433
Query: 257 TLSLN 261
L ++
Sbjct: 434 ELHIS 438
Score = 92.0 bits (227), Expect = 2e-18
Identities = 69/220 (31%), Positives = 109/220 (49%), Gaps = 4/220 (1%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
DL+ N + ++ F L LE L+L N++S + AF GL + +L L+ N L + +
Sbjct: 217 DLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNS 276
Query: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
+L+ L +L L L N I+ + + + L L L N LT + +L L +L +
Sbjct: 277 GSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVL 336
Query: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHL---GTHSFEGLHNLETLDLNYNKLQE 196
L+ N ISHI + AF+ L SL VL L +N I + +F GL +L L L NK++
Sbjct: 337 RLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKS 396
Query: 197 FPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 235
A L L+ L N I+++ AF+ L+ +H
Sbjct: 397 VAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELH 436
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 120 bits (300), Expect = 8e-27
Identities = 113/370 (30%), Positives = 167/370 (45%), Gaps = 44/370 (11%)
Query: 67 LMLQNNQLGGIPAEALWELPSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTE 124
L LQNNQL +P L L L++L L NLIS +P+ +FE L+ L+HL + N L+
Sbjct: 77 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 136
Query: 125 IPVRALNNLP-ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGT--HSFEGL 181
P LP +L+ LA N++ I F +L ++LHNN++ + G +F G
Sbjct: 137 AP----QFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGS 192
Query: 182 HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 241
+ TL L+ N+L P ++ L+ L NN I +P A L+ ++ N +
Sbjct: 193 EAIATLSLSNNQLSYLPPSLPP--SLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQL 250
Query: 242 QFVGRSAFQYLPKLHTLSLNGAMDIQ-------------------------EFPDLKGTT 276
G A + KLH+L Q E L G
Sbjct: 251 TDSGLDATTF-SKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGAR 309
Query: 277 SLEILTL--TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNR 333
L L L + G LP+G + L L L L N ++ +P +L R +L + L HN
Sbjct: 310 GLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPR--RLRALVLPHNH 367
Query: 334 IWEIGADTFSQLSSLQALDLSWNAIRS--IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLG 391
+ +GA L L+L++N + S +H AF L +L LDL NQLT LP+
Sbjct: 368 VAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPT 427
Query: 392 GLMHLKLKGN 401
GL L+L+ N
Sbjct: 428 GLRTLQLQRN 437
Score = 97.8 bits (242), Expect = 4e-20
Identities = 105/370 (28%), Positives = 158/370 (42%), Gaps = 62/370 (16%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSH--IPGQAFSGLYSLKILMLQNNQLGGI 77
DL+ N + E+ P F L + L N LS+ +P AF G ++ L L NNQL +
Sbjct: 149 DLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYL 208
Query: 78 PAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTE--IPVRALNNLPA 135
P PSL+ L L NLIS VP + + LR L+L N LT+ + + L +
Sbjct: 209 PPSLP---PSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHS 265
Query: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
L+ + L+ N+++ +P + +L +LHL NRI+ + G L L L +N+L
Sbjct: 266 LEYLDLSHNQLTTVPAGLPR---TLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLG 322
Query: 196 EFPV---AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL 252
+ A+R L L L + N + +P P L R L
Sbjct: 323 SSGLPAGALRPLRGLHTLHLYGNGLDRVP-------PALPR------------RLRALVL 363
Query: 253 PKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 312
P H +L GA D+ P G T L + A R+ ++L LR L+L+ NQ+
Sbjct: 364 PHNHVAAL-GARDLVATP---GLTELNLAYNRLASARVHHRAF-RRLRALRSLDLAGNQL 418
Query: 313 EELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSL 372
LP +GL + L+ L L N +R + PE + L L
Sbjct: 419 TRLP----------MGLP---------------TGLRTLQLQRNQLRMLEPEPLAGLDQL 453
Query: 373 VKLDLTDNQL 382
+L L N+L
Sbjct: 454 RELSLAHNRL 463
Score = 71.6 bits (174), Expect = 3e-12
Identities = 68/204 (33%), Positives = 95/204 (46%), Gaps = 14/204 (6%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG--GI 77
DLS N LT + GL R L L L N + + G L+ L+LQ+NQLG G+
Sbjct: 270 DLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGL 326
Query: 78 PAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQ 137
PA AL L L +L L N + VP LR L L N + + R L P L
Sbjct: 327 PAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATPGLT 383
Query: 138 AMTLALNRI--SHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
+ LA NR+ + + AF+ L +L L L N++ L G L TL L N+L+
Sbjct: 384 ELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTG---LRTLQLQRNQLR 440
Query: 196 EF-PVAIRTLGRLQELGFHNNNIK 218
P + L +L+EL +N ++
Sbjct: 441 MLEPEPLAGLDQLRELSLAHNRLR 464
Score = 44.3 bits (103), Expect = 5e-04
Identities = 55/220 (25%), Positives = 97/220 (44%), Gaps = 35/220 (15%)
Query: 253 PKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 312
P++ T+ +G +D++ FPD T + + L+L ++ LP +L LR L L +N I
Sbjct: 51 PRVDTVDCDG-LDLRVFPD-NITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLI 108
Query: 313 --EELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 368
E LP + +L+ + + HN++ + + SL+ DL+ N + I P F
Sbjct: 109 SSEGLPDEAFESLTQLQHLCVAHNKL-SVAPQFLPR--SLRVADLAANQVMEIFPLTFGE 165
Query: 369 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC 428
+L + L +NQL+ GL +G+ A++ ++ ++ Y
Sbjct: 166 KPALRSVYLHNNQLSN------AGLPPDAFRGSEAIATLSLSNN-------QLSYLPPSL 212
Query: 429 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAE 468
P + E LHL + SK P G L+RQ +
Sbjct: 213 PPSL-------------ERLHLQNNLISKVPRGALSRQTQ 239
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 120 bits (300), Expect = 8e-27
Identities = 113/370 (30%), Positives = 167/370 (45%), Gaps = 44/370 (11%)
Query: 67 LMLQNNQLGGIPAEALWELPSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTE 124
L LQNNQL +P L L L++L L NLIS +P+ +FE L+ L+HL + N L+
Sbjct: 79 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 138
Query: 125 IPVRALNNLP-ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGT--HSFEGL 181
P LP +L+ LA N++ I F +L ++LHNN++ + G +F G
Sbjct: 139 AP----QFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGS 194
Query: 182 HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 241
+ TL L+ N+L P ++ L+ L NN I +P A L+ ++ N +
Sbjct: 195 EAIATLSLSNNQLSYLPPSLPP--SLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQL 252
Query: 242 QFVGRSAFQYLPKLHTLSLNGAMDIQ-------------------------EFPDLKGTT 276
G A + KLH+L Q E L G
Sbjct: 253 TDSGLDATTF-SKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGAR 311
Query: 277 SLEILTL--TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNR 333
L L L + G LP+G + L L L L N ++ +P +L R +L + L HN
Sbjct: 312 GLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPR--RLRALVLPHNH 369
Query: 334 IWEIGADTFSQLSSLQALDLSWNAIRS--IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLG 391
+ +GA L L+L++N + S +H AF L +L LDL NQLT LP+
Sbjct: 370 VAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPT 429
Query: 392 GLMHLKLKGN 401
GL L+L+ N
Sbjct: 430 GLRTLQLQRN 439
Score = 97.8 bits (242), Expect = 4e-20
Identities = 105/370 (28%), Positives = 158/370 (42%), Gaps = 62/370 (16%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSH--IPGQAFSGLYSLKILMLQNNQLGGI 77
DL+ N + E+ P F L + L N LS+ +P AF G ++ L L NNQL +
Sbjct: 151 DLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYL 210
Query: 78 PAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTE--IPVRALNNLPA 135
P PSL+ L L NLIS VP + + LR L+L N LT+ + + L +
Sbjct: 211 PPSLP---PSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHS 267
Query: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
L+ + L+ N+++ +P + +L +LHL NRI+ + G L L L +N+L
Sbjct: 268 LEYLDLSHNQLTTVPAGLPR---TLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLG 324
Query: 196 EFPV---AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL 252
+ A+R L L L + N + +P P L R L
Sbjct: 325 SSGLPAGALRPLRGLHTLHLYGNGLDRVP-------PALPR------------RLRALVL 365
Query: 253 PKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 312
P H +L GA D+ P G T L + A R+ ++L LR L+L+ NQ+
Sbjct: 366 PHNHVAAL-GARDLVATP---GLTELNLAYNRLASARVHHRAF-RRLRALRSLDLAGNQL 420
Query: 313 EELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSL 372
LP +GL + L+ L L N +R + PE + L L
Sbjct: 421 TRLP----------MGLP---------------TGLRTLQLQRNQLRMLEPEPLAGLDQL 455
Query: 373 VKLDLTDNQL 382
+L L N+L
Sbjct: 456 RELSLAHNRL 465
Score = 71.6 bits (174), Expect = 3e-12
Identities = 68/204 (33%), Positives = 95/204 (46%), Gaps = 14/204 (6%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG--GI 77
DLS N LT + GL R L L L N + + G L+ L+LQ+NQLG G+
Sbjct: 272 DLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGL 328
Query: 78 PAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQ 137
PA AL L L +L L N + VP LR L L N + + R L P L
Sbjct: 329 PAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATPGLT 385
Query: 138 AMTLALNRI--SHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
+ LA NR+ + + AF+ L +L L L N++ L G L TL L N+L+
Sbjct: 386 ELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTG---LRTLQLQRNQLR 442
Query: 196 EF-PVAIRTLGRLQELGFHNNNIK 218
P + L +L+EL +N ++
Sbjct: 443 MLEPEPLAGLDQLRELSLAHNRLR 466
Score = 44.3 bits (103), Expect = 5e-04
Identities = 55/220 (25%), Positives = 97/220 (44%), Gaps = 35/220 (15%)
Query: 253 PKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 312
P++ T+ +G +D++ FPD T + + L+L ++ LP +L LR L L +N I
Sbjct: 53 PRVDTVDCDG-LDLRVFPD-NITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLI 110
Query: 313 --EELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 368
E LP + +L+ + + HN++ + + SL+ DL+ N + I P F
Sbjct: 111 SSEGLPDEAFESLTQLQHLCVAHNKL-SVAPQFLPR--SLRVADLAANQVMEIFPLTFGE 167
Query: 369 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC 428
+L + L +NQL+ GL +G+ A++ ++ ++ Y
Sbjct: 168 KPALRSVYLHNNQLSN------AGLPPDAFRGSEAIATLSLSNN-------QLSYLPPSL 214
Query: 429 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAE 468
P + E LHL + SK P G L+RQ +
Sbjct: 215 PPSL-------------ERLHLQNNLISKVPRGALSRQTQ 241
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 119 bits (297), Expect = 2e-26
Identities = 105/343 (30%), Positives = 155/343 (45%), Gaps = 53/343 (15%)
Query: 43 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 102
L L+GN++S+I +GL+SL L L N+ + + +A +L L L L+ N I +
Sbjct: 65 LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
Query: 103 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVV 162
F+GL +LR+L+L N++S +P F +L S+
Sbjct: 125 PGIFKGLLNLRNLYLQ------------------------YNQVSFVPRGVFNDLVSVQY 160
Query: 163 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPE 222
L+L NR+ LG+ +F G+ L LDL+ NNNI I E
Sbjct: 161 LNLQRNRLTVLGSGTFVGMVALRILDLS-----------------------NNNILRISE 197
Query: 223 KAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL--NGAMDIQEFPDLKGTTSLEI 280
F L ++ N + V +AF+ L L LSL N IQ F KG +LE
Sbjct: 198 SGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFA-FKGLANLEY 256
Query: 281 LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIG 338
L L + IR + + L+ L LSHN +E L S + L + L NRI I
Sbjct: 257 LLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISID 316
Query: 339 ADTFSQL-SSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN 380
DTF + +SL+ L+LS+N + ++HP L SL+ L N
Sbjct: 317 NDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
Score = 96.7 bits (239), Expect = 9e-20
Identities = 60/175 (34%), Positives = 98/175 (56%)
Query: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
L+ N + L PG+F L L L L N +S +P F+ L S++ L LQ N+L + +
Sbjct: 115 LNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSG 174
Query: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
+ +L+ L L N I + E F+ L +L L+L N LT++P A L +L+ ++
Sbjct: 175 TFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLS 234
Query: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
L+ N I I +AF+ L +L L L N+RI+++ F G++NL+ L L++N L+
Sbjct: 235 LSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLE 289
Score = 93.2 bits (230), Expect = 1e-18
Identities = 80/298 (26%), Positives = 141/298 (47%), Gaps = 7/298 (2%)
Query: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
L+ NN++ + L L L L +++ ++ +AF L L L L NN + +
Sbjct: 67 LTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPG 126
Query: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
L +L++L L N +S VP F L S+++L L N LT + + AL+ +
Sbjct: 127 IFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILD 186
Query: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PV 199
L+ N I I + FQ+L +L L+L +N + + +++FE L +L L L++N ++ P
Sbjct: 187 LSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPF 246
Query: 200 AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 259
A + L L+ L N+ I+ + F G L+ + N ++ + F L L L
Sbjct: 247 AFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLK 306
Query: 260 LNG----AMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIE 313
L+ ++D F ++ SL+IL L+ + L + + L L L+ + N E
Sbjct: 307 LDRNRIISIDNDTFENM--GASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWE 362
Score = 82.0 bits (201), Expect = 2e-15
Identities = 66/239 (27%), Positives = 116/239 (48%), Gaps = 7/239 (2%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
+L N LT L G F + L L LS N++ I F L +L L L +N L +P+
Sbjct: 162 NLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPS 221
Query: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
A L SL+ L L N I + +F+GL++L +L L ++ + + + + L+ +
Sbjct: 222 NAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHL 281
Query: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGL-HNLETLDLNYNKLQEF- 197
L+ N + ++ F L +L+ L L NRI + +FE + +L+ L+L++N L
Sbjct: 282 ILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALH 341
Query: 198 PVAIRTLGRLQELGFHNN----NIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL 252
P ++ L L L ++N N K + + ++ + + + NP GR A +Y+
Sbjct: 342 PRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLNIYCQNPPSMRGR-ALRYI 399
Score = 57.0 bits (136), Expect = 8e-08
Identities = 51/174 (29%), Positives = 75/174 (43%), Gaps = 25/174 (14%)
Query: 215 NNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKG 274
NNI I E G L ++ ++ I +V AF L L+ L LN
Sbjct: 70 NNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNF---------- 119
Query: 275 TTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHN 332
I+ L G+ + L LR L L +NQ+ +P + ++ + LQ N
Sbjct: 120 -------------IKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRN 166
Query: 333 RIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 386
R+ +G+ TF + +L+ LDLS N I I F L +L L L N LT +P
Sbjct: 167 RLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVP 220
>gi|193083139 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 119 bits (297), Expect = 2e-26
Identities = 128/408 (31%), Positives = 181/408 (44%), Gaps = 47/408 (11%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL---KILMLQNNQL-G 75
DLS N ++ LQPG F L LE L L+ N L+ + GL L L L N L
Sbjct: 79 DLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYS 138
Query: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 135
G+ L E PSL +L L N ++ + +F + +L L L N L +I A LP
Sbjct: 139 GLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPR 198
Query: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSF-EGLHNLETLDLNYNKL 194
L + L+ N ++ I D++ Q L VL L N I+ T S + L LDL NKL
Sbjct: 199 LTHLNLSRNSLTCISDFSLQQLR---VLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL 255
Query: 195 QEFPVAIRTLGRLQELGFHNNNIKA------------IPEKAFMGNPLLQTIHFYDNPIQ 242
FP + L RL L NN I+ P + + PL
Sbjct: 256 LHFP-DLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAP--------- 305
Query: 243 FVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLP 300
G ++ + L +L L L+ +I+ PD L+ TSL L L+R +R + LP
Sbjct: 306 -SGNASGRPLSQLLNLDLS-YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLP 363
Query: 301 RLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIR 359
L +L+LSHN +E L L + LQ N + ++ TF+ L+SLQ L+L N +
Sbjct: 364 CLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVS 423
Query: 360 SI-HPE--------AFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKL 398
P+ AFS + SL L L DN+ + L G +H L
Sbjct: 424 PCGGPDEPGPSGCVAFSGITSLRSLSLVDNE---IELLRAGAFLHTPL 468
Score = 84.0 bits (206), Expect = 6e-16
Identities = 118/419 (28%), Positives = 171/419 (40%), Gaps = 63/419 (15%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGL------------------ 61
DL N L +++ G F L L L LS N L+ I + L
Sbjct: 179 DLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQ 238
Query: 62 ----YSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLV--PERSFEGLSSLRHL 115
+ L L L+ N+L P A LP L L L NLI L P + +G+ +
Sbjct: 239 PQAEFQLTWLDLRENKLLHFPDLAA--LPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEG 296
Query: 116 WLDDNALTEIPVRALNN------LPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR 169
W + +P+ A + L L + L+ N I IPD ++LTSL L+L N
Sbjct: 297 W------SALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNC 350
Query: 170 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP 229
++ L L LDL++N L+ + R LG L+ L N ++ +P F
Sbjct: 351 LRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLA 410
Query: 230 LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR 289
LQ ++ N + G G F G TSL L+L I
Sbjct: 411 SLQRLNLQGNRVSPCGGP-----------DEPGPSGCVAF---SGITSLRSLSLVDNEIE 456
Query: 290 LLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQ-KLEEIGLQHNRIWEIGADTFSQLS 346
LL +G P L L+LS N E+ +L + LE + LQ N + + D
Sbjct: 457 LLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVD-LPCFI 514
Query: 347 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGG----LMHLKLKGN 401
L+ L+L+ N R H A++ SL LDL +N + LP + +GG L L L+GN
Sbjct: 515 CLKRLNLAEN--RLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGN 571
Score = 39.3 bits (90), Expect = 0.017
Identities = 31/83 (37%), Positives = 39/83 (46%), Gaps = 6/83 (7%)
Query: 325 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL-- 382
E + L N++ I A ++L+ LDLS N I + P AF L L L L N+L
Sbjct: 52 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAM 111
Query: 383 -TTLPLAGLGGL---MHLKLKGN 401
T L GLG L L L GN
Sbjct: 112 ATALSAGGLGPLPRVTSLDLSGN 134
>gi|5031707 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 119 bits (297), Expect = 2e-26
Identities = 128/408 (31%), Positives = 181/408 (44%), Gaps = 47/408 (11%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL---KILMLQNNQL-G 75
DLS N ++ LQPG F L LE L L+ N L+ + GL L L L N L
Sbjct: 79 DLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYS 138
Query: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 135
G+ L E PSL +L L N ++ + +F + +L L L N L +I A LP
Sbjct: 139 GLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPR 198
Query: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSF-EGLHNLETLDLNYNKL 194
L + L+ N ++ I D++ Q L VL L N I+ T S + L LDL NKL
Sbjct: 199 LTHLNLSRNSLTCISDFSLQQLR---VLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL 255
Query: 195 QEFPVAIRTLGRLQELGFHNNNIKA------------IPEKAFMGNPLLQTIHFYDNPIQ 242
FP + L RL L NN I+ P + + PL
Sbjct: 256 LHFP-DLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAP--------- 305
Query: 243 FVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLP 300
G ++ + L +L L L+ +I+ PD L+ TSL L L+R +R + LP
Sbjct: 306 -SGNASGRPLSQLLNLDLS-YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLP 363
Query: 301 RLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIR 359
L +L+LSHN +E L L + LQ N + ++ TF+ L+SLQ L+L N +
Sbjct: 364 CLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVS 423
Query: 360 SI-HPE--------AFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKL 398
P+ AFS + SL L L DN+ + L G +H L
Sbjct: 424 PCGGPDEPGPSGCVAFSGITSLRSLSLVDNE---IELLRAGAFLHTPL 468
Score = 84.0 bits (206), Expect = 6e-16
Identities = 118/419 (28%), Positives = 171/419 (40%), Gaps = 63/419 (15%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGL------------------ 61
DL N L +++ G F L L L LS N L+ I + L
Sbjct: 179 DLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQ 238
Query: 62 ----YSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLV--PERSFEGLSSLRHL 115
+ L L L+ N+L P A LP L L L NLI L P + +G+ +
Sbjct: 239 PQAEFQLTWLDLRENKLLHFPDLAA--LPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEG 296
Query: 116 WLDDNALTEIPVRALNN------LPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR 169
W + +P+ A + L L + L+ N I IPD ++LTSL L+L N
Sbjct: 297 W------SALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNC 350
Query: 170 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP 229
++ L L LDL++N L+ + R LG L+ L N ++ +P F
Sbjct: 351 LRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLA 410
Query: 230 LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR 289
LQ ++ N + G G F G TSL L+L I
Sbjct: 411 SLQRLNLQGNRVSPCGGP-----------DEPGPSGCVAF---SGITSLRSLSLVDNEIE 456
Query: 290 LLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQ-KLEEIGLQHNRIWEIGADTFSQLS 346
LL +G P L L+LS N E+ +L + LE + LQ N + + D
Sbjct: 457 LLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVD-LPCFI 514
Query: 347 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGG----LMHLKLKGN 401
L+ L+L+ N R H A++ SL LDL +N + LP + +GG L L L+GN
Sbjct: 515 CLKRLNLAEN--RLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGN 571
Score = 39.3 bits (90), Expect = 0.017
Identities = 31/83 (37%), Positives = 39/83 (46%), Gaps = 6/83 (7%)
Query: 325 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL-- 382
E + L N++ I A ++L+ LDLS N I + P AF L L L L N+L
Sbjct: 52 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAM 111
Query: 383 -TTLPLAGLGGL---MHLKLKGN 401
T L GLG L L L GN
Sbjct: 112 ATALSAGGLGPLPRVTSLDLSGN 134
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 118 bits (295), Expect = 3e-26
Identities = 107/361 (29%), Positives = 181/361 (50%), Gaps = 17/361 (4%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIP--GQAFSGLYSLKILMLQNNQLGGI 77
D S N L+ L + L+E++++ N L+ IP G+ S ++ +L L +N + I
Sbjct: 81 DFSHNRLSNWNISL--ESQTLQEVKMNYNELTEIPYFGEPTS---NITLLSLVHNIIPEI 135
Query: 78 PAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA-L 136
A+AL P+L+SL L +N+IS + SF + L++L L +N +T + +NL + L
Sbjct: 136 NAQALQFYPALESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSL 194
Query: 137 QAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQE 196
+ L NR+S IP F+ L L L L NRI+ + +F+GL +L +L + N + +
Sbjct: 195 LVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISK 253
Query: 197 FPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKL 255
A L ++EL +NN+ + + G +LQ ++ N I+ + A+++ +L
Sbjct: 254 LKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRL 313
Query: 256 HTLSLN-GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI-- 312
L L+ + + G + LE L L + + G+ + L L+ L+L +N+I
Sbjct: 314 SELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISW 373
Query: 313 ---EELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL 369
+ + L ++ LQ N+I I F L SL+ LDL+ NAI SI AFS
Sbjct: 374 AIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQT 433
Query: 370 H 370
H
Sbjct: 434 H 434
Score = 108 bits (269), Expect = 3e-23
Identities = 110/347 (31%), Positives = 160/347 (46%), Gaps = 17/347 (4%)
Query: 84 ELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLAL 143
E +LQ ++++ N ++ +P E S++ L L N + EI +AL PAL+++ L+
Sbjct: 95 ESQTLQEVKMNYNELTEIPYFG-EPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSS 153
Query: 144 NRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHN-LETLDLNYNKLQEFPVAIR 202
N IS I +F + L L+L NNRI L F+ L + L + LN N++ P I
Sbjct: 154 NIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIF 212
Query: 203 TLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL-- 260
L LQ L N IK + F G L+++ N I + AF L + L L
Sbjct: 213 KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEH 272
Query: 261 NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SL 318
N + + L G L+ L +++ I + + RL L+LS+NQ+ L +
Sbjct: 273 NNLTRVNK-GWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAF 331
Query: 319 HRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIR---SIHPEAFSTLHSLVKL 375
LE + L NR+ I F LS+LQ LDL N I EAF+ L SL KL
Sbjct: 332 VGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKL 391
Query: 376 DLTDNQ---LTTLPLAGLGGLMHLKLKGNLALS---QAFSKDSFPKL 416
L NQ +T GL L HL L N +S AFS+ +L
Sbjct: 392 ILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKEL 438
Score = 85.1 bits (209), Expect = 3e-16
Identities = 67/219 (30%), Positives = 104/219 (47%), Gaps = 4/219 (1%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
+L N + ++ F L L L++ N +S + AF GL +++ L L++N L +
Sbjct: 221 ELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNK 280
Query: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
L+ L LQ L + N I + ++E L L L N LT + A L L+ +
Sbjct: 281 GWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERL 340
Query: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHL---GTHSFEGLHNLETLDLNYNKLQE 196
L NR++HI D F+ L++L L L NN I + +F GL +L L L N+++
Sbjct: 341 NLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKS 400
Query: 197 F-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI 234
A L L+ L +NN I +I E AF L + I
Sbjct: 401 ITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELI 439
Score = 85.1 bits (209), Expect = 3e-16
Identities = 70/207 (33%), Positives = 101/207 (48%), Gaps = 7/207 (3%)
Query: 17 SARDLSM--NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 74
S R L M N +++L+ G F L +EEL L N+L+ + GL L+ L + N +
Sbjct: 240 SLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAI 299
Query: 75 GGIPAEALWEL-PSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL 133
I +A WE L L L N ++ + E +F GLS L L L DN +T I L
Sbjct: 300 ERISPDA-WEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFL 358
Query: 134 PALQAMTLALNRISHIPD---YAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLN 190
LQ + L N IS + AF LTSL L L N+I+ + +F GL +LE LDLN
Sbjct: 359 SNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLN 418
Query: 191 YNKLQEFPVAIRTLGRLQELGFHNNNI 217
N + + L+EL + +++
Sbjct: 419 NNAIMSIQENAFSQTHLKELILNTSSL 445
Score = 82.4 bits (202), Expect = 2e-15
Identities = 91/349 (26%), Positives = 146/349 (41%), Gaps = 24/349 (6%)
Query: 66 ILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEI 125
+L+L G PA +P L R +P S+ LS L D A+ +
Sbjct: 32 LLLLPAAGAGLCPAPCSCRIPLLDCSRRK------LPAPSWRALSGLLP---PDTAILDF 82
Query: 126 PVRALNNL------PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFE 179
L+N LQ + + N ++ IP Y + +++ +L L +N I + + +
Sbjct: 83 SHNRLSNWNISLESQTLQEVKMNYNELTEIP-YFGEPTSNITLLSLVHNIIPEINAQALQ 141
Query: 180 GLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMG-NPLLQTIHFYD 238
LE+LDL+ N + E + +L+ L NN I + F + L +
Sbjct: 142 FYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNR 201
Query: 239 NPIQFVGRSAFQYLPKLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQ 297
N + + F+ LP L L L + I E +G SL L + R GI L G
Sbjct: 202 NRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFF 260
Query: 298 QLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSW 355
L + LEL HN + + L+ + L+++ + N I I D + L LDLS+
Sbjct: 261 GLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSY 320
Query: 356 NAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 401
N + + AF L L +L+L DN++T + L L L L+ N
Sbjct: 321 NQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNN 369
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 115 bits (288), Expect = 2e-25
Identities = 84/295 (28%), Positives = 146/295 (49%), Gaps = 2/295 (0%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
DLS N L + P F LEE+ LS N ++++ AF+ L++L+ L L+ N+L +P
Sbjct: 63 DLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPL 122
Query: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
L +L L + N I ++ + F+ L +L+ L + DN L I RA + L +L+ +
Sbjct: 123 GVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQL 182
Query: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 199
TL ++ +P A +L SL+ LHL + I ++ ++F+ L +L+ L+++Y L +
Sbjct: 183 TLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMP 242
Query: 200 AIRTLG-RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTL 258
A G L L N N+ +P AF L ++ NPI + F L +L L
Sbjct: 243 ANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQEL 302
Query: 259 SLNGA-MDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 312
+ GA + E +G L +L +++ + L + L VL +++N +
Sbjct: 303 HIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
Score = 90.9 bits (224), Expect = 5e-18
Identities = 88/324 (27%), Positives = 140/324 (43%), Gaps = 32/324 (9%)
Query: 65 KILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTE 124
KIL L N+L + E P L+ + L N+I+ V +F L +LR L L N L
Sbjct: 60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKL 119
Query: 125 IPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNL 184
+P+ L L + ++ N+I + DY FQ+L +L L + +N + ++ +F GL +L
Sbjct: 120 VPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSL 179
Query: 185 ETLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQF 243
E L L L P A+ L L L + NI +P AF L H
Sbjct: 180 EQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAF--KRLFHLKHL------- 230
Query: 244 VGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLR 303
Y P L + N + +L L++T + +P + L L
Sbjct: 231 ----EIDYWPLLDMMPANSLYGL----------NLTSLSVTNTNLSTVPFLAFKHLVYLT 276
Query: 304 VLELSHNQIEELPS-----LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAI 358
L LS+N I + + L R Q+L +G Q + I +F L L+ L++S N +
Sbjct: 277 HLNLSYNPISTIEAGMFSDLIRLQELHIVGAQ---LRTIEPHSFQGLRFLRVLNVSQNLL 333
Query: 359 RSIHPEAFSTLHSLVKLDLTDNQL 382
++ FS+ +L L + +N L
Sbjct: 334 ETLEENVFSSPRALEVLSINNNPL 357
Score = 75.1 bits (183), Expect = 3e-13
Identities = 59/202 (29%), Positives = 101/202 (50%), Gaps = 2/202 (0%)
Query: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75
+ + ++ N+L + F L LE+L L +L+ +P +A S L SL L L++ +
Sbjct: 155 LKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNIN 214
Query: 76 GIPAEALWELPSLQSLRLDA-NLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP 134
+P A L L+ L +D L+ ++P S GL +L L + + L+ +P A +L
Sbjct: 215 NMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLV 273
Query: 135 ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 194
L + L+ N IS I F +L L LH+ +++ + HSF+GL L L+++ N L
Sbjct: 274 YLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLL 333
Query: 195 QEFPVAIRTLGRLQELGFHNNN 216
+ + + R E+ NNN
Sbjct: 334 ETLEENVFSSPRALEVLSINNN 355
Score = 59.3 bits (142), Expect = 2e-08
Identities = 55/193 (28%), Positives = 80/193 (41%), Gaps = 31/193 (16%)
Query: 210 LGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEF 269
L N +K++ + F+ PLL+ I DN I V AF L L +L L G
Sbjct: 62 LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNR----- 116
Query: 270 PDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL-----PSLHRCQKL 324
++L+P G+ L L L++S N+I L LH + L
Sbjct: 117 ------------------LKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSL 158
Query: 325 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTT 384
E + N + I FS L SL+ L L + ++ EA S L SL+ L L +
Sbjct: 159 E---VGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINN 215
Query: 385 LPLAGLGGLMHLK 397
+P+ L HLK
Sbjct: 216 MPVYAFKRLFHLK 228
Score = 44.3 bits (103), Expect = 5e-04
Identities = 33/121 (27%), Positives = 58/121 (47%), Gaps = 2/121 (1%)
Query: 279 EILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWE 336
+IL L++ ++ + P L ++LS N I + + + L + L+ NR+
Sbjct: 60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKL 119
Query: 337 IGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHL 396
+ F+ LS+L LD+S N I + F LH+L L++ DN L + GL+ L
Sbjct: 120 VPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSL 179
Query: 397 K 397
+
Sbjct: 180 E 180
Score = 41.6 bits (96), Expect = 0.003
Identities = 31/107 (28%), Positives = 51/107 (47%)
Query: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75
+++ ++ NL+ + F HL +L L LS N +S I FS L L+ L + QL
Sbjct: 251 LTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLR 310
Query: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNAL 122
I + L L+ L + NL+ + E F +L L +++N L
Sbjct: 311 TIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
Score = 37.4 bits (85), Expect = 0.064
Identities = 22/83 (26%), Positives = 42/83 (50%)
Query: 14 IIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 73
+ ++ +LS N ++ ++ G+F L L+EL + G L I +F GL L++L + N
Sbjct: 273 VYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNL 332
Query: 74 LGGIPAEALWELPSLQSLRLDAN 96
L + +L+ L ++ N
Sbjct: 333 LETLEENVFSSPRALEVLSINNN 355
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 114 bits (285), Expect = 4e-25
Identities = 116/370 (31%), Positives = 180/370 (48%), Gaps = 44/370 (11%)
Query: 67 LMLQNNQLGGIPAEALWELPSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTE 124
L LQNNQL I E L L L++L L N ++ +PE++FE L++L +L+L +N LT
Sbjct: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTL 208
Query: 125 IPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLG--THSFEGLH 182
P R L N AL ++ A N ++ I F +L ++LHNN++ G + F G
Sbjct: 209 AP-RFLPN--ALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
Query: 183 NLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQ 242
N+E L L+ N L+ P + L +L NN ++ IP AF L+ ++ +N +
Sbjct: 266 NVEVLILSSNFLRHVPKHLPP--ALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLT 323
Query: 243 FVG--RSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC---- 296
G F L L L L+ + ++ P SL +L L + IR + + +
Sbjct: 324 DEGLDNETFWKLSSLEYLDLS-SNNLSRVP-AGLPRSLVLLHLEKNAIRSVDANVLTPIR 381
Query: 297 ----------------------QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRI 334
Q L RL + L +N +E +PS +++ + + HN+I
Sbjct: 382 SLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPS-GLPRRVRTLMILHNQI 440
Query: 335 WEIGADTFSQLSSLQALDLSWNAIRS--IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGG 392
IG + F+ L+ L+LS+N I S +H +AF L L LDL+ N+L TLP GL
Sbjct: 441 TGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLP-PGLPR 499
Query: 393 LMH-LKLKGN 401
+H LK+K N
Sbjct: 500 NVHVLKVKRN 509
Score = 111 bits (277), Expect = 4e-24
Identities = 126/458 (27%), Positives = 213/458 (46%), Gaps = 36/458 (7%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSH--IPGQAFSGLYSLKILMLQNNQLGGI 77
D + N LT++ F L + L N L+ +P F+G ++++L+L +N L +
Sbjct: 221 DFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHV 280
Query: 78 PAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTE--IPVRALNNLPA 135
P P+L L L N + +P +F LSSLR L+L +N LT+ + L +
Sbjct: 281 PKHLP---PALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSS 337
Query: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
L+ + L+ N +S +P + SLV+LHL N I+ + + + +LE L L+ N+L+
Sbjct: 338 LEYLDLSSNNLSRVPAGLPR---SLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLR 394
Query: 196 E---FPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP-LLQTIHFYDNPIQFVGRSAF-- 249
E P+A + L RL + +NN ++ +P G P ++T+ N I +GR F
Sbjct: 395 EQGIHPLAFQGLKRLHTVHLYNNALERVPS----GLPRRVRTLMILHNQITGIGREDFAT 450
Query: 250 QYLPKLHTLSLNGAMDIQEFPD-LKGTTSLEILTLTRAGIRLLPSGMCQQLPR-LRVLEL 307
Y + LS N Q D + L L L+ + LP G LPR + VL++
Sbjct: 451 TYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPG----LPRNVHVLKV 506
Query: 308 SHNQIEELP--SLHRCQKLEEIGLQHNRIWE--IGADTFSQLSSLQALDLSWNAIRSIHP 363
N++ L +L +L E+ L NR+ +G + L+ LQ LD++ N + I P
Sbjct: 507 KRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEI-P 565
Query: 364 EAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLK---LKGNLALSQAFSKDSFPKLRILE 420
E SL L L +N+++ +P +LK L+ N + +F +L+ L+
Sbjct: 566 EGLP--ESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQ 623
Query: 421 VPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKR 458
V +G + G+ + E+ ++EE R
Sbjct: 624 VLDIEGNLEFGDISKDRGRLGKEKEEEEEEEEEEEETR 661
Score = 76.6 bits (187), Expect = 1e-13
Identities = 80/276 (28%), Positives = 128/276 (46%), Gaps = 22/276 (7%)
Query: 163 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV---AIRTLGRLQELGFHNNNIKA 219
L L NN+++ + LH LETL+L N+L + A L L L NN +
Sbjct: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTL 208
Query: 220 IPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL-NGAMDIQEFPD--LKGTT 276
P F+ N L+ ++ F N + + F P L ++ L N + PD G++
Sbjct: 209 APR--FLPNALI-SVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
Query: 277 SLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRI 334
++E+L L+ +R +P + P L L L +N++E++P + L E+ LQ+N +
Sbjct: 266 NVEVLILSSNFLRHVPKHL---PPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYL 322
Query: 335 WEIGAD--TFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAG 389
+ G D TF +LSSL+ LDLS N + + P SLV L L N + ++ L
Sbjct: 323 TDEGLDNETFWKLSSLEYLDLSSNNLSRV-PAGLP--RSLVLLHLEKNAIRSVDANVLTP 379
Query: 390 LGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAY 425
+ L +L L N Q +F L+ L + Y
Sbjct: 380 IRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLY 415
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/159 (30%), Positives = 82/159 (51%), Gaps = 12/159 (7%)
Query: 15 IISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 74
++ + DLS N L L PGL R + L++ N L+ + A G+ L+ L L +N+L
Sbjct: 479 LLRSLDLSGNRLHTLPPGL---PRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRL 535
Query: 75 --GGIPAEALWELPSLQSLRLDANLISLVPERSFEGL-SSLRHLWLDDNALTEIPVRALN 131
+ A +L LQ L + N ++ +P EGL SL +L+L +N ++ +P A +
Sbjct: 536 RSRALGPRAWVDLAHLQLLDIAGNQLTEIP----EGLPESLEYLYLQNNKISAVPANAFD 591
Query: 132 NLPALQAMTLALNR--ISHIPDYAFQNLTSLVVLHLHNN 168
+ P L+ + L N+ + + D AF+ L L VL + N
Sbjct: 592 STPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 112 bits (281), Expect = 1e-24
Identities = 81/245 (33%), Positives = 126/245 (51%), Gaps = 3/245 (1%)
Query: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
DLS N+ ++ + FH L L L L N L+ + +F+GL SL+ L L +NQL I
Sbjct: 99 DLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAP 158
Query: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
A L +L L L++NL+ + R FE L +L L + N + I L L+++
Sbjct: 159 RAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSL 218
Query: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-P 198
LA + I DYA + L SL L ++N++ + + E + L+ LDLN N LQ P
Sbjct: 219 VLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGP 278
Query: 199 VAIRTLGRLQELGFHN-NNIKAIPEKAFMGNPLLQTIHFYDNP-IQFVGRSAFQYLPKLH 256
+ L+ELG +N + +I + A + P L + +NP + F+ AF +LP++
Sbjct: 279 GDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQME 338
Query: 257 TLSLN 261
TL LN
Sbjct: 339 TLMLN 343
Score = 102 bits (255), Expect = 1e-21
Identities = 90/323 (27%), Positives = 148/323 (45%), Gaps = 32/323 (9%)
Query: 67 LMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIP 126
L+LQ+N + + L L +L L L N S + F L L L L++N LT +
Sbjct: 74 LLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLE 133
Query: 127 VRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLET 186
+ L +LQ + L N++ I AF L++L+ LHL++N ++ + + FE L NLE
Sbjct: 134 DHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEI 193
Query: 187 LDLNYNKLQE-FPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG 245
L + NK+ + R L L+ L N++ I + A G L+++ FYDN + V
Sbjct: 194 LMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVP 253
Query: 246 RSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVL 305
R A + +P L L LN L R G P L +
Sbjct: 254 RRALEQVPGLKFLDLNKN------------------PLQRVG----PGDFANM---LHLK 288
Query: 306 ELSHNQIEELPSLHR-----CQKLEEIGLQHN-RIWEIGADTFSQLSSLQALDLSWNAIR 359
EL N +EEL S+ + +L ++ + +N R+ I F L ++ L L+ NA+
Sbjct: 289 ELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALS 348
Query: 360 SIHPEAFSTLHSLVKLDLTDNQL 382
++H + +L +L ++ L N +
Sbjct: 349 ALHQQTVESLPNLQEVGLHGNPI 371
Score = 98.6 bits (244), Expect = 2e-20
Identities = 84/302 (27%), Positives = 136/302 (45%), Gaps = 10/302 (3%)
Query: 41 EELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISL 100
+ L L N + + L +L L L N LP L SL L+ N ++
Sbjct: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
Query: 101 VPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSL 160
+ + SF GL+SL+ L+L+ N L I RA + L L + L N + I F+ L +L
Sbjct: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNL 191
Query: 161 VVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKA 219
+L + N++ + +F L NL +L L L+E A+ L L+ L F++N +
Sbjct: 192 EILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
Query: 220 IPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG-----AMDIQEFPDLKG 274
+P +A P L+ + NP+Q VG F + L L LN ++D +L
Sbjct: 252 VPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPE 311
Query: 275 TTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL--PSLHRCQKLEEIGLQHN 332
T L+I R + + LP++ L L++N + L ++ L+E+GL N
Sbjct: 312 LTKLDITNNPR--LSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGN 369
Query: 333 RI 334
I
Sbjct: 370 PI 371
Score = 65.9 bits (159), Expect = 2e-10
Identities = 70/307 (22%), Positives = 114/307 (37%), Gaps = 68/307 (22%)
Query: 115 LWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLG 174
L L N++ + L L L + L+ N S D F L L+ LHL N++ L
Sbjct: 74 LLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLE 133
Query: 175 THSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI 234
HSF GL +L QEL ++N + I +AF G L +
Sbjct: 134 DHSFAGLASL-----------------------QELYLNHNQLYRIAPRAFSGLSNLLRL 170
Query: 235 HFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSG 294
H N ++ + F+ LP L L + G + D+ + +L AG+ L
Sbjct: 171 HLNSNLLRAIDSRWFEMLPNLEILMI-GGNKVDAILDMNFRPLANLRSLVLAGMNLR--- 226
Query: 295 MCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLS 354
E+S +E L Q LE + N++ + Q+ L+ LDL+
Sbjct: 227 -----------EISDYALEGL------QSLESLSFYDNQLARVPRRALEQVPGLKFLDLN 269
Query: 355 WNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFP 414
N ++ + P F+ + +HLK G + + S D F
Sbjct: 270 KNPLQRVGPGDFANM------------------------LHLKELGLNNMEELVSIDKFA 305
Query: 415 KLRILEV 421
+ + E+
Sbjct: 306 LVNLPEL 312
Score = 48.1 bits (113), Expect = 4e-05
Identities = 44/138 (31%), Positives = 66/138 (47%), Gaps = 14/138 (10%)
Query: 299 LPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 356
LP+L L L NQ+ L S L+E+ L HN+++ I FS LS+L L L+ N
Sbjct: 116 LPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSN 175
Query: 357 AIRSIHPEAFSTLHSLVKLDLTDNQLTTL------PLAGLGGL----MHLKLKGNLALS- 405
+R+I F L +L L + N++ + PLA L L M+L+ + AL
Sbjct: 176 LLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEG 235
Query: 406 -QAFSKDSFPKLRILEVP 422
Q+ SF ++ VP
Sbjct: 236 LQSLESLSFYDNQLARVP 253
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,509,502
Number of Sequences: 37866
Number of extensions: 1875124
Number of successful extensions: 10453
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 241
Number of HSP's successfully gapped in prelim test: 112
Number of HSP's that attempted gapping in prelim test: 5792
Number of HSP's gapped (non-prelim): 1888
length of query: 915
length of database: 18,247,518
effective HSP length: 111
effective length of query: 804
effective length of database: 14,044,392
effective search space: 11291691168
effective search space used: 11291691168
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.