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Search of human proteins with 61742797
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61742797 basal cell adhesion molecule isoform 2 precursor
[Homo sapiens]
(588 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61742797 basal cell adhesion molecule isoform 2 precursor [Ho... 1190 0.0
gi|31543106 basal cell adhesion molecule isoform 1 precursor [Ho... 1190 0.0
gi|71274107 melanoma cell adhesion molecule [Homo sapiens] 213 5e-55
gi|68163411 activated leukocyte cell adhesion molecule [Homo sap... 154 2e-37
gi|118572606 hemicentin 1 [Homo sapiens] 110 3e-24
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 101 2e-21
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 101 2e-21
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 101 2e-21
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 87 6e-17
gi|109150416 peroxidasin [Homo sapiens] 84 3e-16
gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens] 81 2e-15
gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens] 80 5e-15
gi|166295173 kin of IRRE like [Homo sapiens] 80 5e-15
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 79 9e-15
gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens] 79 9e-15
gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens] 79 9e-15
gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens] 79 9e-15
gi|126517478 peroxidasin homolog-like [Homo sapiens] 77 4e-14
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi... 76 1e-13
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 76 1e-13
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 75 1e-13
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 73 8e-13
gi|139948432 adlican [Homo sapiens] 73 8e-13
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 70 5e-12
gi|21686977 cell adhesion molecule 4 [Homo sapiens] 69 2e-11
gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Ho... 68 2e-11
gi|224994173 roundabout 1 isoform d [Homo sapiens] 66 1e-10
gi|224994171 roundabout 1 isoform c [Homo sapiens] 66 1e-10
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 66 1e-10
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 66 1e-10
>gi|61742797 basal cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 588
Score = 1190 bits (3079), Expect = 0.0
Identities = 588/588 (100%), Positives = 588/588 (100%)
Query: 1 MEPPDAPAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHD 60
MEPPDAPAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHD
Sbjct: 1 MEPPDAPAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHD 60
Query: 61 HYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDE 120
HYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDE
Sbjct: 61 HYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDE 120
Query: 121 RDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPA 180
RDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPA
Sbjct: 121 RDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPA 180
Query: 181 PKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAH 240
PKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAH
Sbjct: 181 PKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAH 240
Query: 241 YSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPE 300
YSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPE
Sbjct: 241 YSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPE 300
Query: 301 YTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAY 360
YTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAY
Sbjct: 301 YTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAY 360
Query: 361 LDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGPMLSLSSITFDSNG 420
LDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGPMLSLSSITFDSNG
Sbjct: 361 LDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGPMLSLSSITFDSNG 420
Query: 421 TYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPD 480
TYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPD
Sbjct: 421 TYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPD 480
Query: 481 PKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTV 540
PKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTV
Sbjct: 481 PKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTV 540
Query: 541 SPQTSQAGVAVMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGAP 588
SPQTSQAGVAVMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGAP
Sbjct: 541 SPQTSQAGVAVMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGAP 588
>gi|31543106 basal cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 628
Score = 1190 bits (3079), Expect = 0.0
Identities = 588/588 (100%), Positives = 588/588 (100%)
Query: 1 MEPPDAPAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHD 60
MEPPDAPAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHD
Sbjct: 1 MEPPDAPAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHD 60
Query: 61 HYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDE 120
HYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDE
Sbjct: 61 HYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDE 120
Query: 121 RDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPA 180
RDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPA
Sbjct: 121 RDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPA 180
Query: 181 PKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAH 240
PKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAH
Sbjct: 181 PKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAH 240
Query: 241 YSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPE 300
YSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPE
Sbjct: 241 YSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPE 300
Query: 301 YTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAY 360
YTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAY
Sbjct: 301 YTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAY 360
Query: 361 LDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGPMLSLSSITFDSNG 420
LDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGPMLSLSSITFDSNG
Sbjct: 361 LDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGPMLSLSSITFDSNG 420
Query: 421 TYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPD 480
TYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPD
Sbjct: 421 TYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPD 480
Query: 481 PKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTV 540
PKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTV
Sbjct: 481 PKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTV 540
Query: 541 SPQTSQAGVAVMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGAP 588
SPQTSQAGVAVMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGAP
Sbjct: 541 SPQTSQAGVAVMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGAP 588
>gi|71274107 melanoma cell adhesion molecule [Homo sapiens]
Length = 646
Score = 213 bits (541), Expect = 5e-55
Identities = 181/626 (28%), Positives = 280/626 (44%), Gaps = 91/626 (14%)
Query: 12 GAPRLLLLAVLLAAH------PDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDHYM-L 64
G PRL+ A LLAA E P LVEV G + +L C + + + +
Sbjct: 2 GLPRLVC-AFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV 60
Query: 65 EWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQ-------GRLVLAEAQV 117
+WF S + L + +G+S P + + + L L +
Sbjct: 61 DWF------------SVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTP 108
Query: 118 GDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNG 177
DER ++C + + E +L V+ PE + N + V +E+ATC RNG
Sbjct: 109 QDERIFLC--QGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNG 166
Query: 178 NPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHC 237
P P++ WY+NG+ L+ E N +S+TV E+SGL +L S L +L K+D+DA F+C
Sbjct: 167 YPIPQVIWYKNGRPLK--EEKNRVHIQSSQTV-ESSGLYTLQSILKAQLVKEDKDAQFYC 223
Query: 238 AAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSP 297
+Y LP G H + +S + + YPTE V V P G ++EGD V++ C DG+P
Sbjct: 224 ELNYRLPSGNHMK-ESREVTVPVFYPTEKVWLEV----EPVGMLKEGDRVEIRCLADGNP 278
Query: 298 SPEYTLFR----LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKT 353
P +++ + ++ +EE N N G L LE + SG Y C+ D D + LS+
Sbjct: 279 PPHFSISKQNPSTREAEEETTNDN--GVLVLEPARKEHSGRYECQGLDLDTMISL-LSEP 335
Query: 354 LELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDST--PLGDGPMLSL 411
EL V Y+ + +S SS + C +W ++ T L GP+L L
Sbjct: 336 QELLVNYVSDVRVSPA-APERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQL 394
Query: 412 SSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSW-REGDEVT 470
+ ++ G Y C AS+P++P L+RTQ + + G P + E + W +E +
Sbjct: 395 HDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERK-----VWVKENMVLN 449
Query: 471 LICSARGHPDPKLSWSQLG-GSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHG 529
L C A GHP P +SW+ G S + P R V S+L + VT L G+ C ASN G
Sbjct: 450 LSCEASGHPRPTISWNVNGTASEQDQDPQR---VLSTLNVLVTPELLETGVECTASNDLG 506
Query: 530 NKRHVFHFGTVS----------------------------------PQTSQAGVAVMAVA 555
+ V+ P+ GV ++AV
Sbjct: 507 KNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGVVIVAVI 566
Query: 556 VSVGLLLLVVAVFYCVRRKGGPCCRQ 581
V + +L ++ AV Y + +KG CR+
Sbjct: 567 VCILVLAVLGAVLYFLYKKGKLPCRR 592
>gi|68163411 activated leukocyte cell adhesion molecule [Homo
sapiens]
Length = 583
Score = 154 bits (389), Expect = 2e-37
Identities = 133/484 (27%), Positives = 216/484 (44%), Gaps = 48/484 (9%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEI 169
L ++ A++ DE+ +VC++ EA + VF +P E+ L + + +++
Sbjct: 98 LSISNARISDEKRFVCML-VTEDNVFEAPTIVKVFKQPSKPEIVSK--ALFLETEQLKKL 154
Query: 170 ATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKD 229
C S + P ITWYRNG+ L P+E + + + + L ++TSTL + K
Sbjct: 155 GDCISEDSYPDGNITWYRNGKVLH-PLE-GAVVIIFKKEMDPVTQLYTMTSTLEYKTTKA 212
Query: 230 DRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQL 289
D F C+ Y P G+ + S ++YPTE V V P ++EGD + L
Sbjct: 213 DIQMPFTCSVTYYGPSGQK-TIHSEQAVFDIYYPTEQVTIQVLPPKNA---IKEGDNITL 268
Query: 290 LCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQ 349
C G+G+P PE LF L + E + + N TL V R +G Y C + D
Sbjct: 269 KCLGNGNPPPEEFLFYLPGQPEGIRSSN---TYTLTDVRRNATGDYKCSL-----IDKKS 320
Query: 350 LSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGPML 409
+ + + V YLD L L+ ++ + + V+C++ + W KD+ L P
Sbjct: 321 MIASTAITVHYLD-LSLNPSGEVTRQIGDALPVSCTISASRNATVVWMKDNIRLRSSP-- 377
Query: 410 SLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEV 469
S SS+ + G YVCE +L V L + ++ TL+V+G P++K + K D S G
Sbjct: 378 SFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKMTK---KTDPS---GLSK 431
Query: 470 TLICSARGHPDPKLSWSQLGG----SPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEAS 525
T+IC G P P + W+ G + E P G S + + ++ ++C A
Sbjct: 432 TIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISPEENVT---LTCTAE 488
Query: 526 NPHGNKRHVFHFGTVS-PQTSQA------------GVAVMAVAVSVGLLL--LVVAVFYC 570
N + + +S P+ +A A + V + VGLLL LV V Y
Sbjct: 489 NQLERTVNSLNVSAISIPEHDEADEISDENREKVNDQAKLIVGIVVGLLLAALVAGVVYW 548
Query: 571 VRRK 574
+ K
Sbjct: 549 LYMK 552
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 110 bits (276), Expect = 3e-24
Identities = 137/558 (24%), Positives = 223/558 (39%), Gaps = 91/558 (16%)
Query: 8 AQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVE-----------VMRGKSVILDCTPT 56
A+ A R +AV A Q +VR+ VPP+++ V+ KS +++C +
Sbjct: 2838 AKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSS 2897
Query: 57 GTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLV-LAEA 115
G+ PR S + G L H ++ S GR++ +
Sbjct: 2898 GS---------------PAPR-NSWQKDGQPLLEDDH--------HKFLSNGRILQILNT 2933
Query: 116 QVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSR 175
Q+ D YVCV AG+A+ LNV P + P L+V+ ++ + TC
Sbjct: 2934 QITDIGRYVCVAE-NTAGSAKKYFNLNVHVPPSV--IGPKSENLTVVVNNFISL-TCEV- 2988
Query: 176 NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASF 235
+G P P ++W +N E P+++N + T+ G TL + K +
Sbjct: 2989 SGFPPPDLSWLKN----EQPIKLN------TNTLIVPGG-----RTLQIIRAKVSDGGEY 3033
Query: 236 HCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDG 295
C A E + F LT++ P S S VREG +V L C +
Sbjct: 3034 TCIAINQAGESK------KKFSLTVYVPPSIKDH--DSESLSVVNVREGTSVSLECESNA 3085
Query: 296 SPSPEYTLFRLQDEQEEVLNVNLEGN---LTLEGVTRGQSGTYGCRVEDYDAADDVQLSK 352
P P T ++ E +V + + L ++ +G Y CR + DD K
Sbjct: 3086 VPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDD----K 3141
Query: 353 TLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTP---------- 402
L V +E E +V+ +++ + C G+P P + W K+
Sbjct: 3142 NFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVR 3201
Query: 403 -LGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLL-VQGSPELKTAEIEPKAD 460
L G L ++ +G Y C AS + + Q + L +Q P + AEI +D
Sbjct: 3202 ILSGGSKLQIARSQHSDSGNYTCIAS----NMEGKAQKYYFLSIQVPPSVAGAEI--PSD 3255
Query: 461 GSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRD-- 518
S G+ V L+C+A G P P + W + G A R ++ TL + AL+ D
Sbjct: 3256 VSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTG 3315
Query: 519 GISCEASNPHGNKRHVFH 536
+C A+NP G + +F+
Sbjct: 3316 KYTCVATNPAGEEDRIFN 3333
Score = 97.1 bits (240), Expect = 4e-20
Identities = 103/400 (25%), Positives = 167/400 (41%), Gaps = 63/400 (15%)
Query: 106 SQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDS 165
S G L +A Q GD Y C+ A AG++ + +L V P + +G +V E+S
Sbjct: 4129 SSGSLQIAFVQPGDAGHYTCMA-ANVAGSSSTSTKLTVHVPPR---IRSTEGHYTVNENS 4184
Query: 166 AQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLR 225
Q I C + +G P P I W ++ L + + E G L L + +
Sbjct: 4185 -QAILPCVA-DGIPTPAINWKKDNVLL---------ANLLGKYTAEPYGELILENVVL-- 4231
Query: 226 LRKDDRDASFH-CAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREG 284
D+ F+ C A+ + E H T LT+H + G S + +G
Sbjct: 4232 -----EDSGFYTCVANNAAGEDTH------TVSLTVHVLPTFTEL-PGDVS-----LNKG 4274
Query: 285 DTVQLLCRGDGSPSPEYT-LFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYD 343
+ ++L C+ G P P+ T F +VN L +E V++ SGTY C E+
Sbjct: 4275 EQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAEN-- 4332
Query: 344 AADDVQLSKTLELRVAYLDPLELSEGKVLSL---PLNSSAVVNCSVHGLPTPALRWTKDS 400
+ + Y+ + +G S PL +A++NC V G PTP ++W +
Sbjct: 4333 -----SVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKG 4387
Query: 401 T---------PLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELK 451
LG+G + ++ D+ G Y C A+ V+ R+ + TL Q P +
Sbjct: 4388 VDIEISHRIRQLGNGSLAIYGTVNEDA-GDYTCVAT-NEAGVVERSMSLTL--QSPPIIT 4443
Query: 452 TAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGS 491
+E + G ++ L C A G P P ++WS+ G S
Sbjct: 4444 LEPVETVINA----GGKIILNCQATGEPQPTITWSRQGHS 4479
Score = 86.3 bits (212), Expect = 7e-17
Identities = 103/411 (25%), Positives = 161/411 (39%), Gaps = 78/411 (18%)
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
R Y++ S G + + Q+ Y CV R AAG+A L+V P + P
Sbjct: 3940 RGDGYRILSSGAIEILATQLNHAGRYTCVAR-NAAGSAHRHVTLHVHEPPV---IQPQPS 3995
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVP----VEMNPEGYMTSRTVREAS 213
L V+ ++ + C + G P+P ITW + G + + G SR VRE +
Sbjct: 3996 ELHVILNNPI-LLPCEA-TGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDA 4053
Query: 214 GLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRH-GRLDSPTFHLTLHYPTEHVQFWVG 272
G ++ C A P G G++ L + P V
Sbjct: 4054 G-------------------TYMCVAQN--PAGTALGKIK-----LNVQVPP------VI 4081
Query: 273 SPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFR-----LQDEQEEVLNVNLEGNLTLEGV 327
SP + + L C DG P P+ T + ++ ++ VL+ G+L + V
Sbjct: 4082 SPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLS---SGSLQIAFV 4138
Query: 328 TRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVH 387
G +G Y C AA+ S T ++ P S ++ NS A++ C
Sbjct: 4139 QPGDAGHYTCM-----AANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVAD 4193
Query: 388 GLPTPALRWTKDST------------PLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLS 435
G+PTPA+ W KD+ P G+ L L ++ + +G Y C A+
Sbjct: 4194 GIPTPAINWKKDNVLLANLLGKYTAEPYGE---LILENVVLEDSGFYTCVANNAAG---E 4247
Query: 436 RTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWS 486
T +L V P E D S +G+++ L C A G P PKL+W+
Sbjct: 4248 DTHTVSLTVHVLPTF----TELPGDVSLNKGEQLRLSCKATGIPLPKLTWT 4294
Score = 82.4 bits (202), Expect = 1e-15
Identities = 123/549 (22%), Positives = 216/549 (39%), Gaps = 83/549 (15%)
Query: 37 VPPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTR 96
+P V V+ G++V L C G +++W + +AS E + ++V+ + +
Sbjct: 3252 IPSDVSVLLGENVELVCNANGIPTP-LIQWLKDGKP-----IASGETE--RIRVSANGST 3303
Query: 97 GRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNK 156
L + A D Y CV AG + LNV+ P
Sbjct: 3304 -------------LNIYGALTSDTGKYTCVA-TNPAGEEDRIFNLNVYVTPTIRGNKDEA 3349
Query: 157 GTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLL 216
L + D++ I C + G P P+I W +NG L +P+ + + +R
Sbjct: 3350 EKLMTLVDTSINIE-CRA-TGTPPPQINWLKNG--LPLPLSSHIRLLAAGQVIR------ 3399
Query: 217 SLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPST 276
+R + D A Y+ +D+ ++L + P S T
Sbjct: 3400 ------IVRAQVSD-------VAVYTCVASNRAGVDNKHYNLQVFAPPN----MDNSMGT 3442
Query: 277 PAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGN-----LTLEGVTRGQ 331
V +G + + C DG+P+P ++ L+D Q L+ +L + L L
Sbjct: 3443 EEITVLKGSSTSMACITDGTPAP--SMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETED 3500
Query: 332 SGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELS---EGKVLSLPLNSSAVVNCSVHG 388
SG Y C + + ++SK L+V L+P ++ E + +S+ +N+ + C G
Sbjct: 3501 SGKYTCIASN----EAGEVSKHFILKV--LEPPHINGSEEHEEISVIVNNPLELTCIASG 3554
Query: 389 LPTPALRWTKDSTP---------LGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQN 439
+P P + W KD P LG G +L +S+ + G Y C AS P +
Sbjct: 3555 IPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAG---DDDKE 3611
Query: 440 FTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGR 499
+ + V P + + EP+ D + +VTL C + P P ++W + G + P R
Sbjct: 3612 YLVRVHVPPNIAGTD-EPR-DITVLRNRQVTLECKSDAVPPPVITWLR-NGERLQATP-R 3667
Query: 500 QGWVSSSLTLKVTSALSRD--GISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAVS 557
+S L++ +A D +C ASN G F P + G + + ++
Sbjct: 3668 VRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLN 3727
Query: 558 VGLLLLVVA 566
+L +A
Sbjct: 3728 KSTVLECIA 3736
Score = 81.3 bits (199), Expect = 2e-15
Identities = 130/580 (22%), Positives = 216/580 (37%), Gaps = 91/580 (15%)
Query: 6 APAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVE--------VMRGKSVILDCTPTG 57
A AQ +A A + EV + VPP ++ V++ K V L C G
Sbjct: 1793 AQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANG 1852
Query: 58 THDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLV-LAEAQ 116
+ + W D+ ++ +G ++ S GR++ +A+
Sbjct: 1853 IPNP-SITWLKDDQP-------------------VNTAQGN---LKIQSSGRVLQIAKTL 1889
Query: 117 VGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRN 176
+ D Y CV AAG + +L+V P + ++ + Q C +
Sbjct: 1890 LEDAGRYTCVA-TNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQ--LECKAA- 1945
Query: 177 GNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFH 236
GNP P ITWY++ + L TS T ++ + S A
Sbjct: 1946 GNPVPVITWYKDNRLLSGS---------TSMTFLNRGQIIDIES------------AQIS 1984
Query: 237 CAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGS 296
A Y + L +H GS + A V + V+L C G
Sbjct: 1985 DAGIYKCVAINSAGATELFYSLQVHVAPSIS----GSNNMVA--VVVNNPVRLECEARGI 2038
Query: 297 PSPEYTLFRLQDEQEEVLN--VNLEGN--LTLEGVTRGQSGTYGCRVEDYDAADDVQLSK 352
P+P T + N L G L L +G Y C +AA + Q +
Sbjct: 2039 PAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVA--VNAAGEKQ--R 2094
Query: 353 TLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGPMLSLS 412
++LRV Y+ P + E + +S+ ++ + + C +P P L W KD PL P LS+S
Sbjct: 2095 DIDLRV-YVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSIS 2153
Query: 413 ---------SITFDSNGTYVCEASLPTVPVLSRTQ-NFTLLVQGSPELKTAEIEPKADGS 462
G Y CEA+ V +T+ N+ + + P + + + +
Sbjct: 2154 ENRSVLKIEDAQVQDTGRYTCEAT----NVAGKTEKNYNVNIWVPPNIGGS--DELTQLT 2207
Query: 463 WREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDG--I 520
EG+ ++L+C + G P P L W + G GR +S L+++ A D
Sbjct: 2208 VIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALY 2267
Query: 521 SCEASNPHGNKRHVFHFGT-VSPQTSQAGVAVMAVAVSVG 559
SC ASN G + ++ + P + +G + V+ G
Sbjct: 2268 SCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRG 2307
Score = 80.1 bits (196), Expect = 5e-15
Identities = 107/447 (23%), Positives = 165/447 (36%), Gaps = 58/447 (12%)
Query: 97 GRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNK 156
G Y + G L + A V D Y+C+ AAGT L V P ++P
Sbjct: 3755 GNHARYSILENGFLHIQSAHVTDTGRYLCMA-TNAAGTDRRRIDLQVHVPPS---IAPGP 3810
Query: 157 GTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLL 216
++V+ + Q C + G P P I W +NG L V N ++S ++ S +
Sbjct: 3811 TNMTVIVN-VQTTLACEA-TGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSV 3868
Query: 217 SLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPT-FHLTLHYPTEHVQFWVGSPS 275
T+T + D +P D PT F +T H P G P
Sbjct: 3869 DDTATYECTVTNGAGDDKRTVDLTVQVPPSI---ADEPTDFLVTKHAPAVITCTASGVPF 3925
Query: 276 TPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTY 335
W + G ++LL RGDG + G + + +G Y
Sbjct: 3926 PSIHWTKNG--IRLLPRGDG------------------YRILSSGAIEILATQLNHAGRY 3965
Query: 336 GCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALR 395
C + AA TL + + P+ + L + LN+ ++ C G P+P +
Sbjct: 3966 TCVARN--AAGSAHRHVTLHV---HEPPVIQPQPSELHVILNNPILLPCEATGTPSPFIT 4020
Query: 396 WTKDSTPLGDGPM---------LSLSSITFDSNGTYVCEASLPTVPVLSRTQ-NFTLLVQ 445
W K+ + L +S + GTY+C A P L + + N +
Sbjct: 4021 WQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPV 4080
Query: 446 GSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSS 505
SP LK I +TL C A G P P ++W + G + E I R V S
Sbjct: 4081 ISPHLKEYVIAVDKP--------ITLSCEADGLPPPDITWHKDGRAIVESIRQR---VLS 4129
Query: 506 SLTLKVTSALSRDG--ISCEASNPHGN 530
S +L++ D +C A+N G+
Sbjct: 4130 SGSLQIAFVQPGDAGHYTCMAANVAGS 4156
Score = 79.3 bits (194), Expect = 9e-15
Identities = 109/459 (23%), Positives = 166/459 (36%), Gaps = 60/459 (13%)
Query: 103 QLDSQGR-LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSV 161
Q+ S GR L L AQ+ D Y CV AAG + L V+ P N +SV
Sbjct: 2060 QVLSGGRILALTSAQISDTGRYTCVA-VNAAGEKQRDIDLRVYVPPNIMGEEQN---VSV 2115
Query: 162 MEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTST 221
+ A E+ C S + P P +TW ++G P+ P ++ E +L +
Sbjct: 2116 LISQAVELL-CQS-DAIPPPTLTWLKDGH----PLLKKP-----GLSISENRSVLKI--- 2161
Query: 222 LYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWV 281
DA Y+ +++ + P GS V
Sbjct: 2162 ---------EDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIG----GSDELTQLTV 2208
Query: 282 REGDTVQLLCRGDGSPSPEYTLFR-----LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYG 336
EG+ + LLC G P P + L D V ++ L + + + Y
Sbjct: 2209 IEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYS 2268
Query: 337 CRVEDYDAADDVQLSKTLELRVAYLDPLELSEGK---VLSLPLNSSAVVNCSVHGLPTPA 393
C + K L+V Y+ P + G + + S + C V G+P P
Sbjct: 2269 CVASNVAGT----AKKEYNLQV-YIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPT 2323
Query: 394 LRWTKDSTP---------LGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRT-QNFTLL 443
+ W KD P L +G +L L +I G YVC A V V T + + L
Sbjct: 2324 VTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVA----VNVAGMTDKKYDLS 2379
Query: 444 VQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWV 503
V P + P+ + S E + V+L C A G P P ++W + G + R
Sbjct: 2380 VHAPPSIIGNHRSPE-NISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSG 2438
Query: 504 SSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSP 542
L L T+ +C N G +R +F + P
Sbjct: 2439 GRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVP 2477
Score = 77.4 bits (189), Expect = 3e-14
Identities = 110/466 (23%), Positives = 176/466 (37%), Gaps = 72/466 (15%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEI 169
L +A+ + DE Y C+ +AGT A +V P +V PN T++ E +
Sbjct: 484 LDIAKVTLSDEGFYECIA-VSSAGTGRAQTFFDVSEPPPVIQV-PNNVTVTPGERAVLTC 541
Query: 170 ATCNSRNGNPAPKITWYRNGQ--RLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLR 227
++ + N +TW RN + RL P + RT+ S L L+
Sbjct: 542 LIISAVDYN----LTWQRNDRDVRLAEPARI--------RTLANLS--------LELKSV 581
Query: 228 KDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTV 287
K + +HC G + + LT+ P + T G V
Sbjct: 582 KFNDAGEYHCMV------SSEGGSSAASVFLTVQEPPKVTVMPKNQSFTG------GSEV 629
Query: 288 QLLCRGDGSPSPE--YTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAA 345
++C G P P+ +T+ + + +G L ++ +G YGC + A
Sbjct: 630 SIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASN-SAG 688
Query: 346 DDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKD------ 399
D Q S LR L + + ++L + L V+ C G+P P ++W K
Sbjct: 689 TDKQNST---LRYIEAPKLMVVQSELL-VALGDITVMECKTSGIPPPQVKWFKGDLELRP 744
Query: 400 STPLGDGPMLSLSSITFDSN---GTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIE 456
ST L P+L L I + G Y C A + R L GSP + I+
Sbjct: 745 STFLIIDPLLGLLKIQETQDLDAGDYTCVA----INEAGRATGKITLDVGSPPVF---IQ 797
Query: 457 PKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVS----SSLTLKVT 512
AD S G VTL C +G+P+P + W +L P P +S +L +
Sbjct: 798 EPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNL 857
Query: 513 SALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAVSV 558
A + CEA N FG + +T+ ++A + +
Sbjct: 858 WASDKGTYICEAEN---------QFGKIQSETTVTVTGLVAPLIGI 894
Score = 75.9 bits (185), Expect = 1e-13
Identities = 95/468 (20%), Positives = 171/468 (36%), Gaps = 55/468 (11%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEI 169
L + A+V D +Y C+ AG ++ L V+ P + ++ + +
Sbjct: 3020 LQIIRAKVSDGGEYTCIA-INQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVS 3078
Query: 170 ATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKD 229
C S N P P ITWY+NG R + E++ + L L ++K
Sbjct: 3079 LECES-NAVPPPVITWYKNG-----------------RMITESTHVEILADGQMLHIKKA 3120
Query: 230 DRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQL 289
+ + GR D FHL ++ P + P + V L
Sbjct: 3121 EVSDTGQYVCRAINVAGR----DDKNFHLNVYVPPS-----IEGPEREVIVETISNPVTL 3171
Query: 290 LCRGDGSPSPEYTLFRLQD--EQEEVLNVNLEGNLTLEGVTRGQ---SGTYGCRVEDYDA 344
C G P P + E + L V + + + R Q SG Y C + +
Sbjct: 3172 TCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231
Query: 345 ADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPL- 403
++++ + S+ VL L + + C+ +G+PTP ++W KD P+
Sbjct: 3232 KAQKYYFLSIQVPPSVAGAEIPSDVSVL---LGENVELVCNANGIPTPLIQWLKDGKPIA 3288
Query: 404 ----------GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTA 453
+G L++ G Y C A T P + F L V +P ++
Sbjct: 3289 SGETERIRVSANGSTLNIYGALTSDTGKYTCVA---TNPAGEEDRIFNLNVYVTPTIRGN 3345
Query: 454 EIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTS 513
+ E + + + + + C A G P P+++W + G P P+ +++ +++
Sbjct: 3346 KDEAEKLMTLVD-TSINIECRATGTPPPQINWLK-NGLPL-PLSSHIRLLAAGQVIRIVR 3402
Query: 514 ALSRD--GISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAVSVG 559
A D +C ASN G ++ +P + + V G
Sbjct: 3403 AQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKG 3450
Score = 74.7 bits (182), Expect = 2e-13
Identities = 106/472 (22%), Positives = 186/472 (39%), Gaps = 68/472 (14%)
Query: 100 PPYQLDSQGRLV-LAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGT 158
P +L +G+++ L A+ D+ Y C V + AAG +L ++ P +
Sbjct: 1499 PNVELLDRGQVLHLKNARRNDKGRYQCTV-SNAAGKQAKDIKLTIYIPPSIKGGNVTTD- 1556
Query: 159 LSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSL 218
+SV+ +S ++ C +R G P P ITWY++GQ + +S L +
Sbjct: 1557 ISVLINSLIKLE-CETR-GLPMPAITWYKDGQ-----------------PIMSSSQALYI 1597
Query: 219 TSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPA 278
YL + + A +A Y+ +FH+ ++ P G+ +TP
Sbjct: 1598 DKGQYLHIPR----AQVSDSATYTCHVANVAGTAEKSFHVDVYVP----PMIEGNLATPL 1649
Query: 279 G-WVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGN------LTLEGVTRGQ 331
V ++ L C+ G+PSP T + + N+ +E ++ + + RGQ
Sbjct: 1650 NKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQ 1709
Query: 332 SGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLS---LPLNSSAVVNCSVHG 388
Y C A V K ++ V L P + G S + +N+ ++C V G
Sbjct: 1710 ---YIC------VATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTG 1760
Query: 389 LPTPALRWTKDSTPLGD---------GPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQN 439
P P + W KD + + G L ++ + G Y C A+ +
Sbjct: 1761 SPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAG---DHKKE 1817
Query: 440 FTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGR 499
F + V P +K++ + + ++ V L C A G P+P ++W + P G
Sbjct: 1818 FEVTVHVPPTIKSSGLSERVVVKYK---PVALQCIANGIPNPSITWLK-DDQPVNTAQGN 1873
Query: 500 QGWVSSSLTLKVTSALSRDG--ISCEASNPHG-NKRHVFHFGTVSPQTSQAG 548
SS L++ L D +C A+N G ++H+ P AG
Sbjct: 1874 LKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAG 1925
Score = 70.1 bits (170), Expect = 5e-12
Identities = 114/466 (24%), Positives = 182/466 (39%), Gaps = 61/466 (13%)
Query: 104 LDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVME 163
LD L L V D YVCV AG + L+V A P + +SV+E
Sbjct: 2342 LDEGHILQLKNIHVSDTGRYVCVA-VNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVE 2400
Query: 164 DSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASG--LLSLTST 221
++ + TC + +G P P ITW+++G PV + S +VR SG +L L T
Sbjct: 2401 KNSVSL-TCEA-SGIPLPSITWFKDGW----PVSL-------SNSVRILSGGRMLRLMQT 2447
Query: 222 LYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWV 281
+ + C + E R F L++ P H+ VG + V
Sbjct: 2448 TM------EDAGQYTCVVRNAAGEER------KIFGLSVLVP-PHI---VGENTLEDVKV 2491
Query: 282 REGDTVQLLCRGDGSPSPEYTLFR-LQDEQEEVLNVNLEGN--LTLEGVTRGQSGTYGCR 338
+E +V L C G+P PE T + Q QE+ + + G L + V +G Y C
Sbjct: 2492 KEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCL 2551
Query: 339 VEDYDAADDVQLSKTLELRVAYLDPLELSEG-----KVLSLPLNSSAVVNCSVHGLPTPA 393
++ S++ L V ++ P G + +++ LNS + C + P
Sbjct: 2552 A----SSPAGHKSRSFSLNV-FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPAT 2606
Query: 394 LRWTKDSTPLGD---------GPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLL- 443
+ W KD TPL G L + + D+ G Y C A+ ++ + +
Sbjct: 2607 ITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIP 2666
Query: 444 -VQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGW 502
+ +L + PK + + + +TL C A P LSW + G P +
Sbjct: 2667 PIINKGDLWGPGLSPK-EVKIKVNNTLTLECEAYAIPSASLSWYK-DGQPLKS-DDHVNI 2723
Query: 503 VSSSLTLKVTSALSRD--GISCEASNPHGNKRHVFHFGTVSPQTSQ 546
++ TL++ A D +C ASN G F P + Q
Sbjct: 2724 AANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQ 2769
Score = 70.1 bits (170), Expect = 5e-12
Identities = 135/580 (23%), Positives = 211/580 (36%), Gaps = 112/580 (19%)
Query: 8 AQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVE---------VMRGKSVILDCTPTGT 58
AQ R LA A D + VR+ VPP + V+R + V L+C
Sbjct: 3589 AQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKS--- 3645
Query: 59 HDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGR-LVLAEAQV 117
P + + G LQ T P ++ S GR L + A +
Sbjct: 3646 -------------DAVPPPVITWLRNGERLQAT--------PRVRILSGGRYLQINNADL 3684
Query: 118 GDERDYVCVVRAGAAGTAE-----ATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATC 172
GD +Y CV A T N+ P++ + NK T V+E A+
Sbjct: 3685 GDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKST--VLECIAE----- 3737
Query: 173 NSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRD 232
G P P+ITW ++G L G ++ E +G L + S +
Sbjct: 3738 ----GVPTPRITWRKDGAVLA--------GNHARYSILE-NGFLHIQSAHVTDTGR---- 3780
Query: 233 ASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCR 292
+ C A + R R+D L +H P +P V L C
Sbjct: 3781 --YLCMATNAAGTDRR-RID-----LQVHVPPSI------APGPTNMTVIVNVQTTLACE 3826
Query: 293 GDGSPSPEYTLFRLQ-----DEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADD 347
G P P + D+ + + G+L + + + TY C V + A DD
Sbjct: 3827 ATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTN-GAGDD 3885
Query: 348 VQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDS---TPLG 404
+T++L V + P E + ++ AV+ C+ G+P P++ WTK+ P G
Sbjct: 3886 ---KRTVDLTVQ-VPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRG 3941
Query: 405 DG------PMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPK 458
DG + + + + G Y C A S ++ TL V P ++ E
Sbjct: 3942 DGYRILSSGAIEILATQLNHAGRYTCVARNAAG---SAHRHVTLHVHEPPVIQPQPSELH 3998
Query: 459 ADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRD 518
+ + L C A G P P ++W + G + GR V S L+++ A+ D
Sbjct: 3999 V----ILNNPILLPCEATGTPSPFITWQKEGIN--VNTSGRNHAVLPSGGLQISRAVRED 4052
Query: 519 G--ISCEASNPHGN-----KRHVFHFGTVSPQTSQAGVAV 551
C A NP G K +V +SP + +AV
Sbjct: 4053 AGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAV 4092
Score = 69.3 bits (168), Expect = 9e-12
Identities = 119/502 (23%), Positives = 194/502 (38%), Gaps = 105/502 (20%)
Query: 68 LTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGR-LVLAEAQVGDERDYVCV 126
L + SG P + +GS + + D+ GR ++ S GR L ++ A+ D Y CV
Sbjct: 2217 LCESSGIPPPNLIWKKKGSPV---LTDSMGR---VRILSGGRQLQISIAEKSDAALYSCV 2270
Query: 127 VRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWY 186
+ AGTA+ L V+ +P T + + V + + C + G P P +TW
Sbjct: 2271 A-SNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLE-CEVQ-GIPPPTVTWM 2327
Query: 187 RNGQRL--EVPVEMNPEGYM----------TSRTVREASGLLSLTSTLYLRLRKDDRDAS 234
++G L VE+ EG++ T R V A + +T Y D S
Sbjct: 2328 KDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKY--------DLS 2379
Query: 235 FHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGD 294
H +P + H E++ V E ++V L C
Sbjct: 2380 VH----------------APPSIIGNHRSPENIS------------VVEKNSVSLTCEAS 2411
Query: 295 GSPSPEYTLFRLQDEQEEVLNVN---LEGN--LTLEGVTRGQSGTYGCRVEDYDAADDVQ 349
G P P T F+ D L+ + L G L L T +G Y C V + +
Sbjct: 2412 GIPLPSITWFK--DGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKI 2469
Query: 350 LSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGD---- 405
++ + + L + KV S + C V G P P + W KD PL +
Sbjct: 2470 FGLSVLVPPHIVGENTLEDVKVKE---KQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAH 2526
Query: 406 -----GPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKAD 460
G L ++++ G Y C AS P ++++F+L V SP + +D
Sbjct: 2527 HIISGGRFLQITNVQVPHTGRYTCLASSPAG---HKSRSFSLNVFVSPTIAGV----GSD 2579
Query: 461 GSWRE-----GDEVTLICSARGHPDPKLSWSQLGGSPAEP------IPGRQGWVSSSLTL 509
G+ + +L+C A +P ++W + G+P E +PG + TL
Sbjct: 2580 GNPEDVTVILNSPTSLVCEAYSYPPATITWFK-DGTPLESNRNIRILPGGR-------TL 2631
Query: 510 KVTSALSRDG--ISCEASNPHG 529
++ +A + SC A+N G
Sbjct: 2632 QILNAQEDNAGRYSCVATNEAG 2653
Score = 68.2 bits (165), Expect = 2e-11
Identities = 100/418 (23%), Positives = 160/418 (38%), Gaps = 73/418 (17%)
Query: 106 SQGRLV-LAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMED 164
S GR++ L + + D Y CVVR AAG L+V P + TL ++
Sbjct: 2437 SGGRMLRLMQTTMEDAGQYTCVVR-NAAGEERKIFGLSVLVPPHIV----GENTLEDVKV 2491
Query: 165 SAQEIATCNSR-NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
++ T GNP P+ITW+++GQ L+ EA ++S L
Sbjct: 2492 KEKQSVTLTCEVTGNPVPEITWHKDGQPLQED---------------EAHHIISGGRFLQ 2536
Query: 224 LRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAG-WVR 282
+ + + C A S P G R +L+ VGS P V
Sbjct: 2537 ITNVQVPHTGRYTCLA--SSPAGHKSR------SFSLNVFVSPTIAGVGSDGNPEDVTVI 2588
Query: 283 EGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVN-LEGNLTLE--GVTRGQSGTYGCRV 339
L+C P T F+ E N+ L G TL+ +G Y C V
Sbjct: 2589 LNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSC-V 2647
Query: 340 EDYDAADDVQLSKTLELRVAYLDPLELSEG---------KVLSLPLNSSAVVNCSVHGLP 390
+A + + K E++V Y+ P+ +++G K + + +N++ + C + +P
Sbjct: 2648 ATNEAGEMI---KHYEVKV-YIPPI-INKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIP 2702
Query: 391 TPALRWTKDSTPL---------GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQ-NF 440
+ +L W KD PL +G L + G Y C AS + + +F
Sbjct: 2703 SASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVAS----NIAGEDELDF 2758
Query: 441 TLLVQGSPEL-KTAEIEPKADGSWREGD--------EVTLICSARGHPDPKLSWSQLG 489
+ +Q P K EI D + R G+ ++L C P P L+W + G
Sbjct: 2759 DVNIQVPPSFQKLWEIGNMLD-TGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDG 2815
Score = 67.0 bits (162), Expect = 5e-11
Identities = 105/488 (21%), Positives = 172/488 (35%), Gaps = 66/488 (13%)
Query: 97 GRSPPYQLDSQGRL-VLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKP---EATEV 152
GR P + G L V+A D +Y+CV AGT E L V P + +V
Sbjct: 1309 GREPGISILEDGTLLVIASVTPYDNGEYICVA-VNEAGTTERKYNLKVHVPPVIKDKEQV 1367
Query: 153 SPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREA 212
+ L+ + + E+ G P+P I WY++ + V E+
Sbjct: 1368 TNVSVLLNQLTNLFCEV------EGTPSPIIMWYKDNVQ-----------------VTES 1404
Query: 213 SGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVG 272
S + ++ + L+L + A+ A YS F++ + P + G
Sbjct: 1405 STIQTVNNGKILKLFR----ATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII----G 1456
Query: 273 SPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFR------LQDEQEEVLNVNLEGNLTLEG 326
+ V V L C+ G+P P+ F+ L D E+L+ L L+
Sbjct: 1457 TNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV--LHLKN 1514
Query: 327 VTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKV---LSLPLNSSAVVN 383
R G Y C V + + T+ + P + G V +S+ +NS +
Sbjct: 1515 ARRNDKGRYQCTVSNAAGKQAKDIKLTIYI------PPSIKGGNVTTDISVLINSLIKLE 1568
Query: 384 CSVHGLPTPALRWTKDSTP---------LGDGPMLSLSSITFDSNGTYVCEASLPTVPVL 434
C GLP PA+ W KD P + G L + + TY C +
Sbjct: 1569 CETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVA-NVAGTA 1627
Query: 435 SRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAE 494
++ + + V P + + + +TL C A G+P P L+W + G
Sbjct: 1628 EKSFHVDVYV---PPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKA 1684
Query: 495 PIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAV 554
R L + + R C A++ G K + + P + G
Sbjct: 1685 NDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYF 1744
Query: 555 AVSVGLLL 562
V V LL
Sbjct: 1745 IVMVNNLL 1752
Score = 64.7 bits (156), Expect = 2e-10
Identities = 96/400 (24%), Positives = 154/400 (38%), Gaps = 60/400 (15%)
Query: 104 LDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKP--EATEVSPNKGTLSV 161
+D L + AQV D Y C V A AGTAE + ++V+ P E +P + +
Sbjct: 1597 IDKGQYLHIPRAQVSDSATYTCHV-ANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVI 1655
Query: 162 MEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTST 221
E GNP+P +TW ++G VPV+ N +R +G L
Sbjct: 1656 AHSLTLECKAA----GNPSPILTWLKDG----VPVKANDN-------IRIEAGGKKLE-- 1698
Query: 222 LYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWV 281
+ ++ DR + C A E + + + P G T V
Sbjct: 1699 -IMSAQEIDR-GQYICVATSVAGE------KEIKYEVDVLVPPAIE----GGDETSYFIV 1746
Query: 282 REGDTVQLLCRGDGSPSPEYTLFRLQD----EQEEVLNVNLEGN-LTLEGVTRGQSGTYG 336
+ ++L C GSP P T+ L+D ++ + + L G L + +G Y
Sbjct: 1747 MVNNLLELDCHVTGSPPP--TIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYR 1804
Query: 337 CRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAV-VNCSVHGLPTPALR 395
C + A D K E+ V ++ P S G + + V + C +G+P P++
Sbjct: 1805 CMAAN-TAGDH---KKEFEVTV-HVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSIT 1859
Query: 396 WTKDSTPL----------GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQ 445
W KD P+ G +L ++ + G Y C A T Q+ L V
Sbjct: 1860 WLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVA---TNAAGETQQHIQLHVH 1916
Query: 446 GSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSW 485
P L+ A + + + V L C A G+P P ++W
Sbjct: 1917 EPPSLEDA--GKMLNETVLVSNPVQLECKAAGNPVPVITW 1954
Score = 63.5 bits (153), Expect = 5e-10
Identities = 105/420 (25%), Positives = 159/420 (37%), Gaps = 91/420 (21%)
Query: 102 YQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEA----TEVSPNKG 157
Y++ S G L + A D Y C+ + +AGT + + L P+ +E+ G
Sbjct: 658 YRMTSDGTLFIKNAAPKDAGIYGCLA-SNSAGTDKQNSTLRYIEAPKLMVVQSELLVALG 716
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
++VME C + +G P P++ W++ +E+ P ++ + GLL
Sbjct: 717 DITVME--------CKT-SGIPPPQVKWFKGD------LELRPSTFLI---IDPLLGLLK 758
Query: 218 LTSTLYLRLRKDDRDAS-FHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPST 276
+ T D DA + C A GR T + VGSP
Sbjct: 759 IQET-------QDLDAGDYTCVAI-----NEAGRA------------TGKITLDVGSPPV 794
Query: 277 ----PAGWVRE-GDTVQLLCRGDGSPSPEYTLFRLQDE-------QEEVLNVNLEGNLTL 324
PA E G V L C G P P RL + ++ G L +
Sbjct: 795 FIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFI 854
Query: 325 EGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELS-----EGKVLSLPLNSS 379
+ GTY C E+ + + T+ VA L + S EG+ L+LP
Sbjct: 855 LNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLL 914
Query: 380 AVVNCSVHGLPTPALRWTKDSTPLGDGPMLSLSS--------ITFDSNGTYVCEASLPTV 431
A G P P RW K+S L P +++ S + G Y C AS
Sbjct: 915 A-------GNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASN--- 964
Query: 432 PVLSRTQNFT--LLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
++ T N T ++V P ++ + S EG VTL C A G+P P + WS+ G
Sbjct: 965 --VAGTNNKTTSVVVHVLPTIQHGQ----QILSTIEGIPVTLPCKASGNPKPSVIWSKKG 1018
Score = 63.5 bits (153), Expect = 5e-10
Identities = 118/481 (24%), Positives = 180/481 (37%), Gaps = 83/481 (17%)
Query: 108 GRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKP----EATEVSPNKGTLSVME 163
G L + E Q D DY CV AG A L+V + P E +VS G+ +
Sbjct: 755 GLLKIQETQDLDAGDYTCVA-INEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLP 813
Query: 164 DSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
Q G P P I W R +P+ P + S + +G L +
Sbjct: 814 CYVQ---------GYPEPTIKWRRLDN---MPIFSRP--FSVSSISQLRTGALFI----- 854
Query: 224 LRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVRE 283
L L D+ ++ C A E + G++ S T T V +G + A V E
Sbjct: 855 LNLWASDK-GTYICEA-----ENQFGKIQSETTVTV----TGLVAPLIGISPSVAN-VIE 903
Query: 284 GDTVQLLCRG-DGSPSPEYTLFRLQDE--QEEVLNVNLEGNLTLEGVTRGQSGTYGCRVE 340
G + L C G+P PE + Q + V +G+L +E V G Y C
Sbjct: 904 GQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVAS 963
Query: 341 DYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDS 400
+ ++ KT + V L ++ + ++LS + C G P P++ W+K
Sbjct: 964 NVAGTNN----KTTSVVVHVLPTIQHGQ-QILSTIEGIPVTLPCKASGNPKPSVIWSKK- 1017
Query: 401 TPLGDGPMLSLSSITF---------------DSNGTYVCEASLPTVPVLSRTQNFTLLVQ 445
G ++S SS F + +G YVC A+ T R T+ V+
Sbjct: 1018 -----GELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTAT-NTAGYAKRKVQLTVYVR 1071
Query: 446 --------GSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIP 497
G + K EI A G+EVTL C + P P ++W++ P
Sbjct: 1072 PRVFGDQRGLSQDKPVEISVLA------GEEVTLPCEVKSLPPPIITWAK-ETQLISPFS 1124
Query: 498 GRQGWVSSSLTLKVTSALSRDG--ISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVA 555
R ++ S ++K+T + D C A+N GN P Q G + V
Sbjct: 1125 PRHTFLPSG-SMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQ 1183
Query: 556 V 556
V
Sbjct: 1184 V 1184
Score = 60.5 bits (145), Expect = 4e-09
Identities = 97/487 (19%), Positives = 173/487 (35%), Gaps = 68/487 (13%)
Query: 99 SPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGT 158
SP + G + + E + D Y+CV AG +LNV P+ +G
Sbjct: 1124 SPRHTFLPSGSMKITETRTSDSGMYLCVA-TNIAGNVTQAVKLNVHVPPKI-----QRGP 1177
Query: 159 LSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVE---MNPEGYMT-SRTVREASG 214
+ Q + + G P P ITW + G + V E NP+G ++ + +G
Sbjct: 1178 KHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAG 1237
Query: 215 LLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSP 274
+ + +T D+ + + H ++ + P ++ T E V
Sbjct: 1238 IYTCVATNIAGT--DETEITLHVQEPPTVEDLE------PPYNTTFQ---ERVA------ 1280
Query: 275 STPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDE---QEEVLNVNLEGNL-TLEGVTRG 330
++ C G+P P E +E +++ +G L + VT
Sbjct: 1281 ---------NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPY 1331
Query: 331 QSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLP 390
+G Y C + + + + + + D +++ VL LN + C V G P
Sbjct: 1332 DNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVL---LNQLTNLFCEVEGTP 1388
Query: 391 TPALRWTKDST---------PLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQN-F 440
+P + W KD+ + +G +L L T + G Y C+A + + +Q F
Sbjct: 1389 SPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKA----INIAGTSQKYF 1444
Query: 441 TLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG-----GSPAEP 495
+ V P + + S +V L C +G P P + W + G G P
Sbjct: 1445 NIDVLVPPTIIGTNFPNEV--SVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVE 1502
Query: 496 IPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVA 555
+ R L LK + C SN G + P + + G ++
Sbjct: 1503 LLDR----GQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDIS 1558
Query: 556 VSVGLLL 562
V + L+
Sbjct: 1559 VLINSLI 1565
Score = 60.5 bits (145), Expect = 4e-09
Identities = 90/454 (19%), Positives = 154/454 (33%), Gaps = 54/454 (11%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEI 169
L + EAQ+ D Y CV + AG E +N+ P ++ L + +
Sbjct: 2730 LQIKEAQISDTGRYTCVA-SNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKD 2788
Query: 170 ATCNS-------RNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTL 222
N+ N P P +TWY++G L + +L L
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWYKDGHPL-----------------TSSDKVLILPGGR 2831
Query: 223 YLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVR 282
L++ + A A Y+ DS + + + P + S V
Sbjct: 2832 VLQIPR----AKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP--IIKGANSDLPEEVTVL 2885
Query: 283 EGDTVQLLCRGDGSPSPEYTLFR-----LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGC 337
+ + C GSP+P + + L+D+ + L+ + +T G Y C
Sbjct: 2886 VNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQIT--DIGRYVC 2943
Query: 338 RVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWT 397
E+ + + + + + + P + + L++ +N+ + C V G P P L W
Sbjct: 2944 VAENTAGSAKKYFNLNVHVPPSVIGP----KSENLTVVVNNFISLTCEVSGFPPPDLSWL 2999
Query: 398 KDSTPL---------GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSP 448
K+ P+ G L + G Y C + + F+L V P
Sbjct: 3000 KNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTC---IAINQAGESKKKFSLTVYVPP 3056
Query: 449 ELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLT 508
+K + E + + REG V+L C + P P ++W + G E L
Sbjct: 3057 SIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLH 3116
Query: 509 LKVTSALSRDGISCEASNPHGNKRHVFHFGTVSP 542
+K C A N G FH P
Sbjct: 3117 IKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVP 3150
Score = 59.7 bits (143), Expect = 7e-09
Identities = 105/443 (23%), Positives = 167/443 (37%), Gaps = 65/443 (14%)
Query: 108 GRLVLAEAQVGDERDYVCVVRAGAAGT-AEATARLNVFAKPEATEVSPNKGTLSVMEDSA 166
G L + D+ Y+C +E T + P +SP+ + +
Sbjct: 850 GALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP-LIGISPSVANVI---EGQ 905
Query: 167 QEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRL 226
Q C GNP P+ W +N L NP Y+T R+ +L++
Sbjct: 906 QLTLPCTLLAGNPIPERRWIKNSAMLL----QNP--YITVRS----------DGSLHIER 949
Query: 227 RKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPT-EHVQFWVGSPSTPAGWVREGD 285
+ + C A S G + + S H+ PT +H Q + + EG
Sbjct: 950 VQLQDGGEYTCVA--SNVAGTNNKTTSVVVHVL---PTIQHGQQILSTI--------EGI 996
Query: 286 TVQLLCRGDGSPSPEYTLFR---LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDY 342
V L C+ G+P P + L + +G+L + +SG Y C +
Sbjct: 997 PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNT 1056
Query: 343 D--AADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVN--CSVHGLPTPALRWTK 398
A VQL+ + RV + D LS+ K + + + + V C V LP P + W K
Sbjct: 1057 AGYAKRKVQLTVYVRPRV-FGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAK 1115
Query: 399 DS----------TPLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSP 448
++ T L G M + T DS G Y+C A+ V TQ L V P
Sbjct: 1116 ETQLISPFSPRHTFLPSGSMKITETRTSDS-GMYLCVATNIAGNV---TQAVKLNVHVPP 1171
Query: 449 ELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLT 508
+++ K + G V + C+A+G P P ++WS+ G + G + T
Sbjct: 1172 KIQRGPKHLKV----QVGQRVDIPCNAQGTPLPVITWSK--GGSTMLVDGEHHVSNPDGT 1225
Query: 509 LKVTSALSRDG--ISCEASNPHG 529
L + A D +C A+N G
Sbjct: 1226 LSIDQATPSDAGIYTCVATNIAG 1248
Score = 56.2 bits (134), Expect = 8e-08
Identities = 105/469 (22%), Positives = 168/469 (35%), Gaps = 91/469 (19%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVS-PNKGTLSVMEDSAQE 168
L L A D Y C AGT++ ++V P + PN+ ++ + D A E
Sbjct: 1416 LKLFRATPEDAGRYSCKA-INIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALE 1474
Query: 169 IATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRK 228
G P P I W+++G+ L + + N E LL L+L+ +
Sbjct: 1475 CQV----KGTPFPDIHWFKDGKPLFLG-DPNVE-------------LLDRGQVLHLKNAR 1516
Query: 229 DDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQ 288
+ + C S G+ + LT++ P G T V ++
Sbjct: 1517 RNDKGRYQCTV--SNAAGKQAK----DIKLTIYIPPS----IKGGNVTTDISVLINSLIK 1566
Query: 289 LLCRGDGSPSPEYTLFRLQD---EQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAA 345
L C G P P T ++ + L ++ L + S TY C V +
Sbjct: 1567 LECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGT 1626
Query: 346 DDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVV------NCSVHGLPTPALRWTKD 399
+ K+ + V Y+ P + EG L+ PLN V+ C G P+P L W KD
Sbjct: 1627 AE----KSFHVDV-YVPP--MIEGN-LATPLNKQVVIAHSLTLECKAAGNPSPILTWLKD 1678
Query: 400 STPL---------GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPEL 450
P+ G L + S G Y+C A+ V G E+
Sbjct: 1679 GVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVAT---------------SVAGEKEI 1723
Query: 451 KTAEIEPKADGSWREGDEVT-----------LICSARGHPDPKLSWSQLGGSPAEPIPGR 499
K E++ + GDE + L C G P P + W + G + I R
Sbjct: 1724 K-YEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDG----QLIDER 1778
Query: 500 QGW---VSSSLTLKVTSALSRDGI-SCEASNPHGNKRHVFHFGTVSPQT 544
G+ ++ + + +S G+ C A+N G+ + F P T
Sbjct: 1779 DGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPT 1827
Score = 54.7 bits (130), Expect = 2e-07
Identities = 88/393 (22%), Positives = 141/393 (35%), Gaps = 68/393 (17%)
Query: 179 PAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCA 238
P+ ++WY++GQ L+ +N + + TL ++ + + C
Sbjct: 2702 PSASLSWYKDGQPLKSDDHVN---------------IAANGHTLQIKEAQISDTGRYTCV 2746
Query: 239 AHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDT--------VQLL 290
A E D F + + P + W G R G+ + L
Sbjct: 2747 ASNIAGE------DELDFDVNIQVPPSFQKLWEIGNMLDTG--RNGEAKDVIINNPISLY 2798
Query: 291 CRGDGSPSPEYTLFR---LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADD 347
C + +P P T ++ ++VL + L + +G Y C V +A +D
Sbjct: 2799 CETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTC-VAVNEAGED 2857
Query: 348 VQLSKTLELRVAYLDPLELSEGKVLSLP------LNSSAVVNCSVHGLPTPALRWTKDST 401
+L+ V L P + +G LP +N SA++ C G P P W KD
Sbjct: 2858 -----SLQYDVRVLVP-PIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQ 2911
Query: 402 P---------LGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKT 452
P L +G +L + + G YVC A S + F L V P +
Sbjct: 2912 PLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAG---SAKKYFNLNVHVPPSV-- 2966
Query: 453 AEIEPKADG-SWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKV 511
I PK++ + + ++L C G P P LSW L + V TL++
Sbjct: 2967 --IGPKSENLTVVVNNFISLTCEVSGFPPPDLSW--LKNEQPIKLNTNTLIVPGGRTLQI 3022
Query: 512 TSALSRDG--ISCEASNPHGNKRHVFHFGTVSP 542
A DG +C A N G + F P
Sbjct: 3023 IRAKVSDGGEYTCIAINQAGESKKKFSLTVYVP 3055
Score = 52.0 bits (123), Expect = 2e-06
Identities = 73/333 (21%), Positives = 118/333 (35%), Gaps = 57/333 (17%)
Query: 102 YQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATE----VSPNKG 157
Y + G L+L + D Y CV AAG T L V P TE VS NKG
Sbjct: 4216 YTAEPYGELILENVVLEDSGFYTCVAN-NAAGEDTHTVSLTVHVLPTFTELPGDVSLNKG 4274
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
+++ G P PK+TW N +P + + +
Sbjct: 4275 ---------EQLRLSCKATGIPLPKLTWTFNNN--IIPAHFDSVNGHSELVIE------- 4316
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
R+ K+D ++ C A S+ G + + F P V P
Sbjct: 4317 -------RVSKED-SGTYVCTAENSV-----GFVKAIGFVYVKEPP-------VFKGDYP 4356
Query: 278 AGWVRE-GDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGN--LTLEGVTRGQSGT 334
+ W+ G L C G P+P R + E + GN L + G +G
Sbjct: 4357 SNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGD 4416
Query: 335 YGCRVEDYDAADDVQLSKTLEL-RVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPA 393
Y C + + +S TL+ + L+P+E + ++NC G P P
Sbjct: 4417 YTCVATNEAGVVERSMSLTLQSPPIITLEPVE------TVINAGGKIILNCQATGEPQPT 4470
Query: 394 LRWTKDSTPLGDGPMLSLSSITFDSNGTYVCEA 426
+ W++ + +++ S +N Y+ +A
Sbjct: 4471 ITWSRQGHSISWDDRVNVLS----NNSLYIADA 4499
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 101 bits (252), Expect = 2e-21
Identities = 122/479 (25%), Positives = 188/479 (39%), Gaps = 62/479 (12%)
Query: 99 SPPYQLDSQGRLV-LAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
SP Q+ G+++ ++ A+V D Y+CV AG+AE L V P + +
Sbjct: 1698 SPRLQVLEDGQVLQVSTAEVADAASYMCVAE-NQAGSAEKLFTLRVQVPPRIAGLDLEQV 1756
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
T +++ S C+ + +P P++TWY++ Q L + E+ LL
Sbjct: 1757 T-AILNSSVS--LPCDV-HAHPNPEVTWYKDSQALSLGEEVF---------------LLP 1797
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
T TL L + + C A + GR D L++ P Q +P P
Sbjct: 1798 GTHTLQLGRARLSDSGMYTCEALNAA-----GR-DQKLVQLSVLVPPAFRQ----APRGP 1847
Query: 278 --AGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEG-----NLTLEGVTRG 330
A VR GD L C D P P T ++ D Q VL + L ++
Sbjct: 1848 QDAVLVRVGDKAVLSCETDALPEPTVTWYK--DGQPLVLAQRTQALRGGQRLEIQEAQVS 1905
Query: 331 QSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLP 390
G Y C+V + + T+++ + +P + +V PL V+ C V G+P
Sbjct: 1906 DKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPL----VLTCDVSGVP 1961
Query: 391 TPALRWTKDSTP---------LGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFT 441
P + W KD P + G L LS + GTY C A ++F
Sbjct: 1962 APTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA---EARKDFV 2018
Query: 442 LLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPG--- 498
+ V +P ++++ + + EG EV L C A G P P ++W + GSP G
Sbjct: 2019 VAVLVAPRIRSSGV--AREHHVLEGQEVRLDCEADGQPPPDVAWLK-DGSPLGQDMGPHL 2075
Query: 499 RQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAVS 557
R SL LK A +C A NP G + + P T + G VS
Sbjct: 2076 RFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVS 2134
Score = 93.6 bits (231), Expect = 5e-19
Identities = 104/395 (26%), Positives = 166/395 (42%), Gaps = 61/395 (15%)
Query: 108 GRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQ 167
G+L +A A D +Y+C+ + +AG+A RL V P P+ T + +
Sbjct: 2809 GQLRIAHASPEDAGNYLCIAK-NSAGSAMGKTRLVVQVPPVIENGLPDLSTT----EGSH 2863
Query: 168 EIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLR 227
C +R G+P P ITW ++GQ PV EG T + E L ++
Sbjct: 2864 AFLPCKAR-GSPEPNITWDKDGQ----PVS-GAEGKFTIQPSGE----------LLVKNL 2907
Query: 228 KDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTV 287
+ ++ C A ++ R HLT+ + + P + +R GD +
Sbjct: 2908 EGQDAGTYTCTAENAVGRARR------RVHLTILV----LPVFTTLPGDRS--LRLGDRL 2955
Query: 288 QLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLE--GVTRGQSGTYGCRVEDYDAA 345
L C GSP+P + + D +G TL+ V+R SGTY C E+
Sbjct: 2956 WLRCAARGSPTPRIG-WTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN---- 3010
Query: 346 DDVQLSKTLELRVAYLDPLELSEGKVLSL---PLNSSAVVNCSVHGLPTPALRWTKDSTP 402
++ +T + ++ + +G+ S P+ S ++C V G P P + W KD P
Sbjct: 3011 ---RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 3067
Query: 403 LGDGPM---LSLSSITF-----DSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAE 454
L + L S+T D G Y C A + V + L++Q +P +
Sbjct: 3068 LRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAE-NEMGVAKKV--VILVLQSAPVF---Q 3121
Query: 455 IEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
+EP+ D + R GD+V L C A G P P + W Q G
Sbjct: 3122 VEPQ-DMTVRSGDDVALRCQATGEPTPTIEWLQAG 3155
Score = 84.7 bits (208), Expect = 2e-16
Identities = 116/462 (25%), Positives = 179/462 (38%), Gaps = 68/462 (14%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSP--NKGTLSVMEDSAQ 167
L + A V D Y C AG +E LNV+ P V P TL+V E
Sbjct: 935 LQVDRADVWDAGHYTCEA-LNQAGRSEKHYNLNVWVAP----VFPLRESHTLTVREGHPT 989
Query: 168 EIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTST---LYL 224
++ C R G P PKI+W ++GQ L E +GL +++ LYL
Sbjct: 990 SLS-CECR-GVPFPKISWRKDGQPLP----------------GEGAGLQHVSAVGRLLYL 1031
Query: 225 RLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREG 284
+ ++ ++ C + S L +H P + P T V++G
Sbjct: 1032 GQAQLAQEGTYTCECSNVVGNS------SQDLQLEVHVPPQIAG--PREPPTQVSVVQDG 1083
Query: 285 DTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEG---NLTLEGVTRGQSGTYGCRVED 341
L C G P P T R L + L+ +L +E +G Y C E+
Sbjct: 1084 -VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN 1142
Query: 342 YDAADDVQLSKTLELR---VAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK 398
+ + ++ + + LDPL ++ L+S + C G+P PA+RW +
Sbjct: 1143 LAGRAERKFELSVLVPPELIGDLDPLTN-----ITAALHSPLTLLCEAMGIPPPAIRWFR 1197
Query: 399 DSTPLGDGP---------MLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPE 449
P+ G ML ++ +G Y C AS +NF++ V P
Sbjct: 1198 GEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEA---RRNFSVEVLVPPS 1254
Query: 450 LKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVS-SSLT 508
++ ++E +G L+C+ GHP PKL+W + G A G +S +
Sbjct: 1255 IENEDLEEVI--KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR---GDAHHISPDGVL 1309
Query: 509 LKVTSA-LSRDG-ISCEASNPHGNKRHVFHFGTVSPQTSQAG 548
L+V A LS G SC A+N G K F + T G
Sbjct: 1310 LQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGG 1351
Score = 84.7 bits (208), Expect = 2e-16
Identities = 98/454 (21%), Positives = 170/454 (37%), Gaps = 62/454 (13%)
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
RSP +++ +G L + D Y+C+ + +AG+ L V +P A SP+
Sbjct: 2525 RSPRFEILPEGSLRIQPVLAQDAGHYLCLA-SNSAGSDRQGRDLRVL-EPPAIAPSPSNL 2582
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
TL+ + + C + +G+P P + W+++GQ+L+ ++ + S
Sbjct: 2583 TLTAHTPA---LLPCEA-SGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS----------- 2627
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
+ L L A F C + E RL T H+ + F V +
Sbjct: 2628 --NALLLTAPGPQDSAQFECVVSNEVGEAH--RLYQVTVHVPPTIADDQTDFTVTMMA-- 2681
Query: 278 AGWVREGDTVQLLCRGDGSPSPEYTLFRLQDE---QEEVLNVNLEGNLTLEGVTRGQSGT 334
V L C G P+P + + + + V+ G L + +G
Sbjct: 2682 --------PVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR 2733
Query: 335 YGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPAL 394
Y C + + T++ P+ V+ ++ C G+P P +
Sbjct: 2734 YTCSARNSAGVAHKHVFLTVQ-----ASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTI 2788
Query: 395 RWTKD--------STPLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQG 446
W K+ ST + G L ++ + + G Y+C A + +T+ L+VQ
Sbjct: 2789 TWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTR---LVVQV 2845
Query: 447 SPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQG----W 502
P ++ D S EG L C ARG P+P ++W + G +P+ G +G
Sbjct: 2846 PPVIENG----LPDLSTTEGSHAFLPCKARGSPEPNITWDKDG----QPVSGAEGKFTIQ 2897
Query: 503 VSSSLTLKVTSALSRDGISCEASNPHGNKRHVFH 536
S L +K +C A N G R H
Sbjct: 2898 PSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 2931
Score = 82.8 bits (203), Expect = 8e-16
Identities = 115/446 (25%), Positives = 165/446 (36%), Gaps = 73/446 (16%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEV--SPNKGTLSVMEDSAQ 167
L L A++ D Y C AAG + +L+V P + P L + D A
Sbjct: 1802 LQLGRARLSDSGMYTCEA-LNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKA- 1859
Query: 168 EIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLR 227
+ +C + + P P +TWY++GQ L L T L R
Sbjct: 1860 -VLSCET-DALPEPTVTWYKDGQPLV---------------------LAQRTQALRGGQR 1896
Query: 228 KDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTV 287
+ ++A YS TF LT+ P +P T G +
Sbjct: 1897 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFE-----NPKTETVSQVAGSPL 1951
Query: 288 QLLCRGDGSPSPEYTLF--RLQDEQEEVLNV-NLEGNLTLEGVTRGQSGTYGCRVEDYDA 344
L C G P+P T R+ E V V + G L L + Q+GTY C E+ A
Sbjct: 1952 VLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 2011
Query: 345 ADDVQLSKTLELRVAYLDPLELS----EGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDS 400
+ K + V + S E VL ++C G P P + W KD
Sbjct: 2012 ----EARKDFVVAVLVAPRIRSSGVAREHHVLE---GQEVRLDCEADGQPPPDVAWLKDG 2064
Query: 401 TPLG-----------DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPE 449
+PLG DG L L + G Y C A P +R +LV +
Sbjct: 2065 SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED-ARLHTVNVLVPPT-- 2121
Query: 450 LKTAEIEPKADGSW----REGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSS 505
I+ ADGS R G+ VT++C RG P +SW + G P P+ R S
Sbjct: 2122 -----IKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLK-DGLPL-PLSQRTLLHGS 2174
Query: 506 SLTLKVTSALSRDG--ISCEASNPHG 529
TL+++ D +C A++P G
Sbjct: 2175 GHTLRISKVQLADAGIFTCVAASPAG 2200
Score = 82.4 bits (202), Expect = 1e-15
Identities = 115/449 (25%), Positives = 170/449 (37%), Gaps = 52/449 (11%)
Query: 97 GRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNK 156
G+S + GR AQ G AG AG E + F+ P V
Sbjct: 164 GQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGF-EQFPTPHAFSPPAPPSVLGAG 222
Query: 157 GTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLL 216
V+ + ++ +G P P++ W ++ Q + P G V+E +L
Sbjct: 223 AAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQ------PVLPGG--PHLQVQEDGQVL 274
Query: 217 SLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPST 276
+T + + + C A P G+ R F L +H P W GS T
Sbjct: 275 RITGSHV------GDEGRYQCVAFS--PAGQQAR----DFQLRVHAPPT---IW-GSNET 318
Query: 277 PAGWVREGDTVQLLCRGDGSPSPEYTLFR---LQDEQEEVLNVNLEGNLTLEGVTRGQSG 333
V E VQLLC G P+P T F+ L +V+ L L +G
Sbjct: 319 GEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAG 378
Query: 334 TYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGK--VLSLPLNSSAVVNCSVHGLPT 391
Y C+ + A + K L V +E + G+ V+ + C G P+
Sbjct: 379 VYTCKASNAVGAAE----KATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS 434
Query: 392 PALRWTKDSTPLG---------DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTL 442
P L W + P+ DG +L L S S+G Y C AS P + + +++
Sbjct: 435 PTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ---YSV 491
Query: 443 LVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGW 502
VQ P+L AE + G + L C A G P P + W Q G PAE + G Q
Sbjct: 492 EVQVPPQLLVAE--GLGQVTTIVGQPLELPCQASGSPVPTIQWLQ-NGRPAEELAGVQ-V 547
Query: 503 VSSSLTLKVTSA-LSRDGI-SCEASNPHG 529
S TL + L G+ +C+A+N G
Sbjct: 548 ASQGTTLHIDHVELDHSGLFACQATNEAG 576
Score = 81.6 bits (200), Expect = 2e-15
Identities = 118/446 (26%), Positives = 161/446 (36%), Gaps = 41/446 (9%)
Query: 107 QGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSA 166
+G L LA D DY C G+ A+L V+ P E K +S M +
Sbjct: 56 EGSLFLASVSPADSGDYECQA-TNEVGSTSRRAKLVVYVPPSIRE-DGRKANVSGM--AG 111
Query: 167 QEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRL 226
Q + NG P P+I W ++ Q + VP+ G+ LL +L+
Sbjct: 112 QSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPR 171
Query: 227 RKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPST-PAGWVRE-- 283
+ R A S F +PT H PS AG +E
Sbjct: 172 IQPGRSGRRGAQAGGSAQTKAPWXAGLAGFE---QFPTPHAFSPPAPPSVLGAGAAQEVL 228
Query: 284 ---GDTVQLLCRGDGSPSPEYTLFRLQDEQEEV-----LNVNLEGN-LTLEGVTRGQSGT 334
G V+L C G P+P+ +D Q + L V +G L + G G G
Sbjct: 229 GLAGADVELQCWTSGVPTPQVEW--TKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGR 286
Query: 335 YGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVN--CSVHGLPTP 392
Y C + A Q ++ +LRV + P + + + +V C G+PTP
Sbjct: 287 YQCVA--FSPAG--QQARDFQLRV-HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP 341
Query: 393 ALRWTKDSTPL---------GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLL 443
+ W KD L G L L G Y C+AS T+ L
Sbjct: 342 NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATR---LD 398
Query: 444 VQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWV 503
V P ++ A P + G V L C ARGHP P LSW G AE R
Sbjct: 399 VYVPPTIEGAGGRPYVVKA-VAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETD 457
Query: 504 SSSLTLKVTSALSRDGISCEASNPHG 529
S L L+ S SC AS+P G
Sbjct: 458 GSVLRLESPGEASSGLYSCVASSPAG 483
Score = 80.9 bits (198), Expect = 3e-15
Identities = 120/451 (26%), Positives = 176/451 (39%), Gaps = 87/451 (19%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEI 169
L + + + DE Y C AG ++ L V P + P +V+E+++ +
Sbjct: 659 LQIEKVDLRDEGIYTCAA-TNLAGESKREVALKVLVPPN---IEPGPVNKAVLENASVTL 714
Query: 170 ATCNSRNGNPAPKITWYRNGQRLE--VPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLR 227
S G P P ++W++ Q + + V ++ +G R +R LS
Sbjct: 715 ECLAS--GVPPPDVSWFKGHQPVSSWMGVTVSVDG----RVLRIEQAQLS---------- 758
Query: 228 KDDRDA-SFHCAAHY--SLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREG 284
DA S+ C A E R+G + +TL PS P G V
Sbjct: 759 ----DAGSYRCVASNVAGSTELRYGLRVNVPPRITL------------PPSLP-GPVLVN 801
Query: 285 DTVQLLCRGDGSPSPEYTLFRLQDEQEEV------LNVNLEGN-LTLEGVTRGQSGTYGC 337
V+L C G+PSP TL L+D L V G LTL SG Y C
Sbjct: 802 TPVRLTCNATGAPSP--TLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSC 859
Query: 338 RVEDYDAAD--DVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALR 395
D DV L ++ P L E +S+ N S + C H +P P L
Sbjct: 860 VAVSAVGEDRQDVVLQ-------VHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 912
Query: 396 WTKDSTPLGDGPMLSLSS----ITFD-----SNGTYVCEASLPTVPVLSRTQ-NFTLLVQ 445
W KD PL P + LS+ + D G Y CEA + R++ ++ L V
Sbjct: 913 WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA----LNQAGRSEKHYNLNVW 968
Query: 446 GSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVS- 504
+P E + REG +L C RG P PK+SW + G +P+PG +
Sbjct: 969 VAPVFPLRESHTL---TVREGHPTSLSCECRGVPFPKISWRKDG----QPLPGEGAGLQH 1021
Query: 505 ----SSLTLKVTSALSRDG-ISCEASNPHGN 530
L + L+++G +CE SN GN
Sbjct: 1022 VSAVGRLLYLGQAQLAQEGTYTCECSNVVGN 1052
Score = 76.6 bits (187), Expect = 6e-14
Identities = 119/471 (25%), Positives = 187/471 (39%), Gaps = 77/471 (16%)
Query: 99 SPPYQLDSQGR-LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
+P Q+ GR L LA A+ D Y CV A G L V P N
Sbjct: 832 TPGLQVFPGGRVLTLASARASDSGRYSCVA-VSAVGEDRQDVVLQVHMPPSILGEELN-- 888
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
+SV+ + + + C S + P P ++W+++G+ P+E P ++++
Sbjct: 889 -VSVVANESVALE-CQS-HAMPPPVLSWWKDGR----PLEPRPGVHLSADKA-------- 933
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPE-GRHGRLDSPTFHLTLHYPTEHVQFWVGSPST 276
L + DR A A HY+ + GR + HY ++ WV +P
Sbjct: 934 --------LLQVDR-ADVWDAGHYTCEALNQAGRSEK-------HY---NLNVWV-APVF 973
Query: 277 PAG-----WVREGDTVQLLCRGDGSPSPEYTLFR----LQDEQEEVLNVNLEGNLTLEGV 327
P VREG L C G P P+ + + L E + +V+ G L G
Sbjct: 974 PLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQ 1033
Query: 328 TR-GQSGTYGCRVEDY--DAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNC 384
+ Q GTY C + +++ D+QL + ++A P E +S+ + A + C
Sbjct: 1034 AQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA--GPRE--PPTQVSVVQDGVATLEC 1089
Query: 385 SVHGLPTPALRWTKDSTPLG---------DGPMLSLSSITFDSNGTYVCEASLPTVPVLS 435
+ G P P + W +D P+G G L + G Y C A +
Sbjct: 1090 NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE----NLAG 1145
Query: 436 RTQ-NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAE 494
R + F L V PEL +++P + + +TL+C A G P P + W + G P
Sbjct: 1146 RAERKFELSVLVPPEL-IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR-GEEPVS 1203
Query: 495 PIPGRQGW-VSSSLTLKVTSALSRDG--ISCEASNPHGNKRHVFHFGTVSP 542
PG + ++ LK+T +D SC ASN G R F + P
Sbjct: 1204 --PGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP 1252
Score = 75.1 bits (183), Expect = 2e-13
Identities = 135/534 (25%), Positives = 196/534 (36%), Gaps = 84/534 (15%)
Query: 43 VMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPY 102
V+ G+ V LDC + G P + GS L M G +
Sbjct: 2038 VLEGQEVRLDC----------------EADGQPPPDVAWLKDGSPLGQDM----GPHLRF 2077
Query: 103 QLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVM 162
LD G LVL + D Y CV AG +NV P + + GTL V
Sbjct: 2078 YLDG-GSLVLKGLRASDAGAYTCVAH-NPAGEDARLHTVNVLVPPTIKQGADGSGTL-VS 2134
Query: 163 EDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTL 222
C R G+P ++W ++G L +P ++ RT+ SG S +
Sbjct: 2135 RPGELVTMVCPVR-GSPPIHVSWLKDG--LPLP--------LSQRTLLHGSGHTLRISKV 2183
Query: 223 YLRLRKDDRDAS-FHCAAHYSLPEGRHGRLDSPTFHLTLHYPT--EHVQFWVGSPSTPAG 279
L DA F C A + P G R F L + P E V+F
Sbjct: 2184 QLA------DAGIFTCVA--ASPAGVADR----NFTLQVQVPPVLEPVEFQNDVV----- 2226
Query: 280 WVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEG--NLTLEGVTRGQSGTYGC 337
V G V+L C G P P L + E +L+ +LE +L LE V G SGTY C
Sbjct: 2227 -VVRGSLVELPCEARGVPLP---LVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSC 2282
Query: 338 RVEDYDAADDVQLSKTLELR----VAYLDPLELSE-GKVLSLPLNSSAVVN--CSVHGLP 390
V +S+ E R + ++P + + G+ L L A + C G P
Sbjct: 2283 ----------VAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTP 2332
Query: 391 TPALRWTKDSTPLG--DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSP 448
P + W KD L + + + G Y C A P + ++F + VQ P
Sbjct: 2333 QPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAI---EKSFRVRVQAPP 2389
Query: 449 ELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLT 508
+ P+ G ++ L CS P PK++W + G E + L
Sbjct: 2390 NI-VGPRGPRFVVGLAPG-QLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQ 2447
Query: 509 LKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAVSVGLLL 562
L+ S SC A N G+ F + T ++G + V+V+ LL
Sbjct: 2448 LQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALL 2501
Score = 72.4 bits (176), Expect = 1e-12
Identities = 99/401 (24%), Positives = 155/401 (38%), Gaps = 64/401 (15%)
Query: 108 GRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMED--- 164
GRL L+ Q Y CV A +A AR + A V+P + V +
Sbjct: 1987 GRLQLSRLQPAQAGTYTCV-----AENTQAEARKDFVV---AVLVAPRIRSSGVAREHHV 2038
Query: 165 -SAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
QE+ +G P P + W ++G L + + Y+ G L L
Sbjct: 2039 LEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDG-------GSLVLKG--- 2088
Query: 224 LRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVRE 283
LR D A + C AH P G RL + + + P Q GS + + R
Sbjct: 2089 --LRASDAGA-YTCVAHN--PAGEDARLHT----VNVLVPPTIKQGADGSGTLVS---RP 2136
Query: 284 GDTVQLLCRGDGSPSPEYTLFR----LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGC-- 337
G+ V ++C GSP + + L Q +L+ + L + V +G + C
Sbjct: 2137 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGH-TLRISKVQLADAGIFTCVA 2195
Query: 338 ----RVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPA 393
V D + VQ+ LE V + + + + G ++ LP C G+P P
Sbjct: 2196 ASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELP--------CEARGVPLPL 2246
Query: 394 LRWTKDSTP-----LGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSP 448
+ W KD P L GP L L ++ +GTY C A ++F L V P
Sbjct: 2247 VSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVA---VSEAGEARRHFQLTVMEPP 2303
Query: 449 ELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
++ + + S G + L+C A+G P P ++W + G
Sbjct: 2304 HIE--DSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 2342
Score = 71.2 bits (173), Expect = 2e-12
Identities = 129/555 (23%), Positives = 205/555 (36%), Gaps = 78/555 (14%)
Query: 8 AQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDHYMLEWF 67
AQA R +A LA + + E+ + VPP E++ + + T H L
Sbjct: 1128 AQAAHTGRYSCVAENLAGRAERKFELSVLVPP--ELIGDLDPLTNIT-AALHSPLTL--- 1181
Query: 68 LTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVV 127
L + G P A +G E DT Y L L + + Q D Y C+
Sbjct: 1182 LCEAMGIPPP-AIRWFRGEEPVSPGEDT------YLLAGGWMLKMTQTQEQDSGLYSCLA 1234
Query: 128 RAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYR 187
+ AG A + V P + E + + V++ + CN G+P PK+TW++
Sbjct: 1235 -SNEAGEARRNFSVEVLVPP-SIENEDLEEVIKVLDGQTAHLM-CNV-TGHPQPKLTWFK 1290
Query: 188 NGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGR 247
+G+ L R + +S L L+ A+ A HYS
Sbjct: 1291 DGRPL----------------ARGDAHHISPDGVLLQVLQ-----ANLSSAGHYSCIAAN 1329
Query: 248 HGRLDSPTFHLT-LHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRL 306
+ F L+ L PT + + V + + L+C PSP T +
Sbjct: 1330 AVGEKTKHFQLSVLLAPT--ILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKD 1387
Query: 307 QDEQEEVLNVNL---EGNLTLEGVTRGQSGTYGCRVEDY--DAADDVQLSKTLELRVAYL 361
E N+ L L + + +G Y C V + +A + + + ++
Sbjct: 1388 GAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKD 1447
Query: 362 DPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTP---------LGDGPMLSLS 412
DPL K + +NS+ + C +P P +RW KD P LG+G +L +
Sbjct: 1448 DPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQ 1507
Query: 413 SITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTA-------EI---EPKADGS 462
+G Y+C A T Q+F +L+Q P + EI E +A G
Sbjct: 1508 PTQVSDSGRYLCVA---TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGG 1564
Query: 463 WREGDEVT------LICSARGHPDPKLSWSQLGG--SPAEPIPGRQGWVSSSLTLKVTSA 514
E E+ L C P P L+W + S + + QG L + + A
Sbjct: 1565 VTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQG--GRVLQIPLVRA 1622
Query: 515 LSRDGISCEASNPHG 529
+ SC+ASN G
Sbjct: 1623 ENAGRYSCKASNEVG 1637
Score = 67.0 bits (162), Expect = 5e-11
Identities = 126/520 (24%), Positives = 182/520 (35%), Gaps = 87/520 (16%)
Query: 38 PPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRG 97
P +V+ + G+ V L+C G H L W A + E GS L+
Sbjct: 412 PYVVKAVAGRPVALECVARG-HPSPTLSWHHEGLPVAESNESRLETDGSVLR-------- 462
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
L+S G EA G Y CV + AG A + V P+ V+ G
Sbjct: 463 ------LESPG-----EASSGL---YSCVA-SSPAGEAVLQYSVEVQVPPQLL-VAEGLG 506
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLE----VPVEMNPEGYMTSRTVREAS 213
++ + E+ C + +G+P P I W +NG+ E V V + S
Sbjct: 507 QVTTIVGQPLELP-CQA-SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHS 564
Query: 214 GLLSLTSTLYLRLRKDDRDASFH---CAAHYSLPEGRH--GRLDSPTFHLTLHYPTEHVQ 268
GL + +T + + S H +P G++ G +F P +
Sbjct: 565 GLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVH--R 622
Query: 269 FWVGSPSTPA--GWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEG 326
W P P GW G L G P + +L L +E
Sbjct: 623 GWGAHPKPPLVEGWCSPGS---LWGEPTGIP----------------VAYSLPPPLQIEK 663
Query: 327 VTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPL-NSSAVVNCS 385
V G Y C AA ++ E+ + L P + G V L N+S + C
Sbjct: 664 VDLRDEGIYTC------AATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 717
Query: 386 VHGLPTPALRWTKDSTPLG---------DGPMLSLSSITFDSNGTYVCEASLPTVPVLSR 436
G+P P + W K P+ DG +L + G+Y C AS V
Sbjct: 718 ASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVAS----NVAGS 773
Query: 437 TQ-NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEP 495
T+ + L V P + + P G V L C+A G P P L W + G+P P
Sbjct: 774 TELRYGLRVNVPPRI---TLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK-DGNPVSP 829
Query: 496 --IPGRQGWVSSS-LTLKVTSALSRDGISCEASNPHGNKR 532
PG Q + LTL A SC A + G R
Sbjct: 830 AGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDR 869
Score = 65.9 bits (159), Expect = 1e-10
Identities = 109/474 (22%), Positives = 163/474 (34%), Gaps = 67/474 (14%)
Query: 103 QLDSQGRLV-LAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSV 161
Q+ +GRL+ + QV D Y+CV AG + + + P +V +
Sbjct: 1496 QVLGEGRLLQIQPTQVSDSGRYLCVA-TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEI 1554
Query: 162 M--EDSAQ-------EIATCN------SRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTS 206
+ E+ A+ EI N N P P +TWYR Q L E++
Sbjct: 1555 LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVS------- 1607
Query: 207 RTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEH 266
+L L + L + + + C A + E H L T
Sbjct: 1608 --------VLQGGRVLQIPLVRAENAGRYSCKASNEVGED--------WLHYELLVLTPP 1651
Query: 267 VQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFR--LQDEQEEVLNVNLEGN-LT 323
V V TV L C G+P P + + L L V +G L
Sbjct: 1652 VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQ 1711
Query: 324 LEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVN 383
+ + +Y C E+ + + K LRV + + + ++ LNSS +
Sbjct: 1712 VSTAEVADAASYMCVAENQAGSAE----KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLP 1767
Query: 384 CSVHGLPTPALRWTKDSTPLGDGP---------MLSLSSITFDSNGTYVCEASLPTVPVL 434
C VH P P + W KDS L G L L +G Y CEA +
Sbjct: 1768 CDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEA----LNAA 1823
Query: 435 SRTQNFT-LLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSP- 492
R Q L V P + A P+ R GD+ L C P+P ++W + G P
Sbjct: 1824 GRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK-DGQPL 1882
Query: 493 --AEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQT 544
A+ +G L ++ + SC+ SN G F P T
Sbjct: 1883 VLAQRTQALRG--GQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPT 1934
Score = 65.9 bits (159), Expect = 1e-10
Identities = 128/546 (23%), Positives = 189/546 (34%), Gaps = 86/546 (15%)
Query: 7 PAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDHYMLEW 66
P A+ A L LA A ++R+ PP + + TP
Sbjct: 2541 PVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPA---------L 2591
Query: 67 FLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCV 126
+ SG+ L G +L D R + Y+L L+L D + CV
Sbjct: 2592 LPCEASGSPKPLVVWWKDGQKL-----DFRLQQGAYRLLPSNALLLTAPGPQDSAQFECV 2646
Query: 127 VRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWY 186
V + G A ++ V P + T+++M A + TC+S G PAP ++W
Sbjct: 2647 V-SNEVGEAHRLYQVTVHVPPTIAD-DQTDFTVTMM---APVVLTCHS-TGIPAPTVSWS 2700
Query: 187 RNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEG 246
+ G +L GY S SG L + L + + + C+A S
Sbjct: 2701 KAGAQLGA----RGSGYRVS-----PSGALEIGQALPIHAGR------YTCSARNS---- 2741
Query: 247 RHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRL 306
+ H + + PS E V L C G P P T
Sbjct: 2742 ------AGVAHKHVFLTVQASPVVKPLPSVVRAVAEE--EVLLPCEASGIPRPTITW--- 2790
Query: 307 QDEQEEVLNVNLE--------GNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRV 358
Q+E LNV G L + + +G Y C ++ + + KT R+
Sbjct: 2791 ---QKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS---AMGKT---RL 2841
Query: 359 AYLDPLELSEGKV-LSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGP---------M 408
P + G LS S A + C G P P + W KD P+
Sbjct: 2842 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE 2901
Query: 409 LSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDE 468
L + ++ GTY C A V R + T+LV P T D S R GD
Sbjct: 2902 LLVKNLEGQDAGTYTCTAE-NAVGRARRRVHLTILVL--PVFTTLP----GDRSLRLGDR 2954
Query: 469 VTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPH 528
+ L C+ARG P P++ W+ E + + G S+L S C A N
Sbjct: 2955 LWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG--GSTLQRAAVSREDSGTYVCWAENRV 3012
Query: 529 GNKRHV 534
G + V
Sbjct: 3013 GRTQAV 3018
Score = 65.5 bits (158), Expect = 1e-10
Identities = 113/458 (24%), Positives = 172/458 (37%), Gaps = 52/458 (11%)
Query: 116 QVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSR 175
+V D Y C+ + AG E + R+ V A P V P V Q + C S
Sbjct: 2359 RVRDAGLYTCLAES-PAGAIEKSFRVRVQAPPNI--VGPRGPRFVVGLAPGQLVLEC-SV 2414
Query: 176 NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASF 235
PAPKITW+R+G L+ E T R L ST D D S
Sbjct: 2415 EAEPAPKITWHRDGIVLQ-------EDAHTQFPERGRFLQLQALSTA------DSGDYS- 2460
Query: 236 HCAAHYSLPEGRHGRLDSPTFHLTLH-YPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGD 294
C A + S F + +H PT PA V T L C+ D
Sbjct: 2461 -CTARNAAGS------TSVAFRVEIHTVPTIR-------SGPPAVNVSVNQTALLPCQAD 2506
Query: 295 GSPSPEYTLFRLQ---DEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLS 351
G P+P + + + D + + EG+L ++ V +G Y C + +D
Sbjct: 2507 GVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD----R 2562
Query: 352 KTLELRVAYLDPLELSEG-KVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPL------G 404
+ +LRV L+P ++ L+L ++ A++ C G P P + W KD L G
Sbjct: 2563 QGRDLRV--LEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQG 2620
Query: 405 DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWR 464
+L +++ + G +++ V + L Q + + + + D +
Sbjct: 2621 AYRLLPSNALLLTAPGPQ--DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVT 2678
Query: 465 EGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEA 524
V L C + G P P +SWS+ G G + S +L + + +C A
Sbjct: 2679 MMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSA 2738
Query: 525 SNPHG-NKRHVFHFGTVSPQTSQAGVAVMAVAVSVGLL 561
N G +HVF SP V AVA LL
Sbjct: 2739 RNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 2776
Score = 62.8 bits (151), Expect = 9e-10
Identities = 115/485 (23%), Positives = 176/485 (36%), Gaps = 108/485 (22%)
Query: 28 DAQAEVRLSVPPLVE---------VMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRL 78
D +++ VPP++E V+RG V L C G ++ W P L
Sbjct: 2203 DRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGV-PLPLVSWM----KDGEPLL 2257
Query: 79 ASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEAT 138
+ + QG P QL++ G GD Y CV AG A
Sbjct: 2258 SQSLEQG--------------PSLQLEAVG--------AGDSGTYSCVA-VSEAGEARRH 2294
Query: 139 ARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEM 198
+L V P E S LS+ + E+ C+++ G P P ITW+++GQ L +E
Sbjct: 2295 FQLTVMEPPHI-EDSGQPTELSLTPGAPMELL-CDAQ-GTPQPNITWHKDGQAL-TRLEN 2350
Query: 199 NPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHL 258
N +T LR+R DA + L E G ++ +F +
Sbjct: 2351 NSR------------------ATRVLRVR----DAGLYTC----LAESPAGAIEK-SFRV 2383
Query: 259 TLHYPTEHV-----QFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEV 313
+ P V +F VG + G V L C + P+P+ T R +E
Sbjct: 2384 RVQAPPNIVGPRGPRFVVG--------LAPGQLV-LECSVEAEPAPKITWHRDGIVLQED 2434
Query: 314 LNVNLEGN---LTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGK 370
+ L L+ ++ SG Y C + AA ++ +E+ P S
Sbjct: 2435 AHTQFPERGRFLQLQALSTADSGDYSCTARN--AAGSTSVAFRVEIHTV---PTIRSGPP 2489
Query: 371 VLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGP---------MLSLSSITFDSNGT 421
+++ +N +A++ C G+P P + W KD PL L + + G
Sbjct: 2490 AVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 2549
Query: 422 YVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLI-CSARGHPD 480
Y+C AS S Q L V L+ I P L+ C A G P
Sbjct: 2550 YLCLASNSAG---SDRQGRDLRV-----LEPPAIAPSPSNLTLTAHTPALLPCEASGSPK 2601
Query: 481 PKLSW 485
P + W
Sbjct: 2602 PLVVW 2606
Score = 51.2 bits (121), Expect = 3e-06
Identities = 41/122 (33%), Positives = 57/122 (46%), Gaps = 18/122 (14%)
Query: 384 CSVHGLPTPALRWTK--DSTPLGDGP--------MLSLSSITFDSNGTYVCEASLPTVPV 433
C HG P P + W K S PL P L L+S++ +G Y C+A T V
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQA---TNEV 80
Query: 434 LSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSW---SQLGG 490
S ++ L+V P ++ E KA+ S G +TL C A G P P++ W +QL G
Sbjct: 81 GSTSRRAKLVVYVPPSIR--EDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVG 138
Query: 491 SP 492
P
Sbjct: 139 VP 140
Score = 50.4 bits (119), Expect = 4e-06
Identities = 83/368 (22%), Positives = 135/368 (36%), Gaps = 62/368 (16%)
Query: 97 GRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNK 156
G + + G L++ + D Y C A G A L + P T + P
Sbjct: 2889 GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE-NAVGRARRRVHLTILVLPVFTTL-PGD 2946
Query: 157 GTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTV--REASG 214
+L + + + C +R G+P P+I W N + + V G R RE SG
Sbjct: 2947 RSLRLGD---RLWLRCAAR-GSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSG 3002
Query: 215 LLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSP 274
++ C A E R GR + +F HV+
Sbjct: 3003 -------------------TYVCWA-----ENRVGRTQAVSF--------VHVKEAPVLQ 3030
Query: 275 STPAGWVRE--GDTVQLLC--RGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRG 330
++ E G ++QL C RGD P + L + + G+LT+ R
Sbjct: 3031 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERD 3090
Query: 331 QSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLP 390
+G Y C E+ ++ ++K + + V P+ E + +++ + C G P
Sbjct: 3091 DAGRYQCLAEN-----EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP 3145
Query: 391 TPALRWTKDSTP---------LGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFT 441
TP + W + P L DG L L ++ GTY C A + S T
Sbjct: 3146 TPTIEWLQAGQPLRASRRLRTLPDG-SLWLENVETGDAGTYDCVAH---NLLGSATARAF 3201
Query: 442 LLVQGSPE 449
L+V+G P+
Sbjct: 3202 LVVRGEPQ 3209
Score = 41.6 bits (96), Expect = 0.002
Identities = 32/121 (26%), Positives = 53/121 (43%), Gaps = 13/121 (10%)
Query: 291 CRGDGSPSPEYTLFRLQDEQEEV-----LNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAA 345
C G+P P+ T +R E + + V EG+L L V+ SG Y C+ A
Sbjct: 24 CGTHGTPKPQVT-WRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQ-----AT 77
Query: 346 DDVQLSKTLELRVAYLDPLELSEGKVLSLP--LNSSAVVNCSVHGLPTPALRWTKDSTPL 403
++V + V Y+ P +G+ ++ S + C +G P P + W KD+ +
Sbjct: 78 NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 137
Query: 404 G 404
G
Sbjct: 138 G 138
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 101 bits (252), Expect = 2e-21
Identities = 122/479 (25%), Positives = 188/479 (39%), Gaps = 62/479 (12%)
Query: 99 SPPYQLDSQGRLV-LAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
SP Q+ G+++ ++ A+V D Y+CV AG+AE L V P + +
Sbjct: 2889 SPRLQVLEDGQVLQVSTAEVADAASYMCVAE-NQAGSAEKLFTLRVQVPPRIAGLDLEQV 2947
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
T +++ S C+ + +P P++TWY++ Q L + E+ LL
Sbjct: 2948 T-AILNSSVS--LPCDV-HAHPNPEVTWYKDSQALSLGEEVF---------------LLP 2988
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
T TL L + + C A + GR D L++ P Q +P P
Sbjct: 2989 GTHTLQLGRARLSDSGMYTCEALNAA-----GR-DQKLVQLSVLVPPAFRQ----APRGP 3038
Query: 278 --AGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEG-----NLTLEGVTRG 330
A VR GD L C D P P T ++ D Q VL + L ++
Sbjct: 3039 QDAVLVRVGDKAVLSCETDALPEPTVTWYK--DGQPLVLAQRTQALRGGQRLEIQEAQVS 3096
Query: 331 QSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLP 390
G Y C+V + + T+++ + +P + +V PL V+ C V G+P
Sbjct: 3097 DKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPL----VLTCDVSGVP 3152
Query: 391 TPALRWTKDSTP---------LGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFT 441
P + W KD P + G L LS + GTY C A ++F
Sbjct: 3153 APTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA---EARKDFV 3209
Query: 442 LLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPG--- 498
+ V +P ++++ + + EG EV L C A G P P ++W + GSP G
Sbjct: 3210 VAVLVAPRIRSSGV--AREHHVLEGQEVRLDCEADGQPPPDVAWLK-DGSPLGQDMGPHL 3266
Query: 499 RQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAVS 557
R SL LK A +C A NP G + + P T + G VS
Sbjct: 3267 RFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVS 3325
Score = 93.6 bits (231), Expect = 5e-19
Identities = 104/395 (26%), Positives = 166/395 (42%), Gaps = 61/395 (15%)
Query: 108 GRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQ 167
G+L +A A D +Y+C+ + +AG+A RL V P P+ T + +
Sbjct: 4000 GQLRIAHASPEDAGNYLCIAK-NSAGSAMGKTRLVVQVPPVIENGLPDLSTT----EGSH 4054
Query: 168 EIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLR 227
C +R G+P P ITW ++GQ PV EG T + E L ++
Sbjct: 4055 AFLPCKAR-GSPEPNITWDKDGQ----PVS-GAEGKFTIQPSGE----------LLVKNL 4098
Query: 228 KDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTV 287
+ ++ C A ++ R HLT+ + + P + +R GD +
Sbjct: 4099 EGQDAGTYTCTAENAVGRARR------RVHLTILV----LPVFTTLPGDRS--LRLGDRL 4146
Query: 288 QLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLE--GVTRGQSGTYGCRVEDYDAA 345
L C GSP+P + + D +G TL+ V+R SGTY C E+
Sbjct: 4147 WLRCAARGSPTPRIG-WTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN---- 4201
Query: 346 DDVQLSKTLELRVAYLDPLELSEGKVLSL---PLNSSAVVNCSVHGLPTPALRWTKDSTP 402
++ +T + ++ + +G+ S P+ S ++C V G P P + W KD P
Sbjct: 4202 ---RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 4258
Query: 403 LGDGPM---LSLSSITF-----DSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAE 454
L + L S+T D G Y C A + V + L++Q +P +
Sbjct: 4259 LRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAE-NEMGVAKKV--VILVLQSAPVF---Q 4312
Query: 455 IEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
+EP+ D + R GD+V L C A G P P + W Q G
Sbjct: 4313 VEPQ-DMTVRSGDDVALRCQATGEPTPTIEWLQAG 4346
Score = 86.3 bits (212), Expect = 7e-17
Identities = 115/442 (26%), Positives = 168/442 (38%), Gaps = 55/442 (12%)
Query: 104 LDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVME 163
LD L Q GD Y C AGTA+ L V P + L +
Sbjct: 1365 LDEGQSLHFPRIQEGDSGLYSCRAE-NQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGL-- 1421
Query: 164 DSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
+ ++ +G P P++ W ++ Q + P G V+E +L +T +
Sbjct: 1422 -AGADVELQCWTSGVPTPQVEWTKDRQ------PVLPGG--PHLQVQEDGQVLRITGSHV 1472
Query: 224 LRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVRE 283
+ + C A P G+ R F L +H P W GS T V E
Sbjct: 1473 ------GDEGRYQCVAFS--PAGQQAR----DFQLRVHAPPT---IW-GSNETGEVAVME 1516
Query: 284 GDTVQLLCRGDGSPSPEYTLFR---LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVE 340
VQLLC G P+P T F+ L +V+ L L +G Y C+
Sbjct: 1517 DHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKAS 1576
Query: 341 DYDAADDVQLSKTLELRVAYLDPLELSEGK--VLSLPLNSSAVVNCSVHGLPTPALRWTK 398
+ A + K L V +E + G+ V+ + C G P+P L W
Sbjct: 1577 NAVGAAE----KATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHH 1632
Query: 399 DSTPLG---------DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPE 449
+ P+ DG +L L S S+G Y C AS P + + +++ VQ P+
Sbjct: 1633 EGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ---YSVEVQVPPQ 1689
Query: 450 LKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTL 509
L AE + G + L C A G P P + W Q G PAE + G Q S TL
Sbjct: 1690 LLVAE--GLGQVTTIVGQPLELPCQASGSPVPTIQWLQ-NGRPAEELAGVQ-VASQGTTL 1745
Query: 510 KVTSA-LSRDGI-SCEASNPHG 529
+ L G+ +C+A+N G
Sbjct: 1746 HIDHVELDHSGLFACQATNEAG 1767
Score = 85.1 bits (209), Expect = 2e-16
Identities = 132/526 (25%), Positives = 192/526 (36%), Gaps = 73/526 (13%)
Query: 30 QAEVRLSVPP---------LVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLAS 80
+ E+R+ PP L+E + G++ L C GT +P++
Sbjct: 1196 EVELRVLEPPHWGADETSGLLERVAGENASLPCPARGT---------------PKPQVTW 1240
Query: 81 AEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATAR 140
+ SE +H P + +G L LA D DY C G+ A+
Sbjct: 1241 RKGPSSE---PLHG----QPGVAVLEEGSLFLASVSPADSGDYECQA-TNEVGSTSRRAK 1292
Query: 141 LNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNP 200
L V+ P E K +S M + Q + NG P P+I W ++ Q + VP+
Sbjct: 1293 LVVYVPPSIRE-DGRKANVSGM--AGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAG 1349
Query: 201 EGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTL 260
G+ LL +L+ ++ + C A E + G FHL +
Sbjct: 1350 YGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRA-----ENQAGTAQRD-FHLLV 1403
Query: 261 HYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEV-----LN 315
P + G+ G G V+L C G P+P+ + D Q + L
Sbjct: 1404 LTPPSVLG--AGAAQEVLGLA--GADVELQCWTSGVPTPQVEWTK--DRQPVLPGGPHLQ 1457
Query: 316 VNLEGN-LTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSL 374
V +G L + G G G Y C + A Q ++ +LRV + P + +
Sbjct: 1458 VQEDGQVLRITGSHVGDEGRYQCVA--FSPAG--QQARDFQLRV-HAPPTIWGSNETGEV 1512
Query: 375 PLNSSAVVN--CSVHGLPTPALRWTKDSTPLGD---------GPMLSLSSITFDSNGTYV 423
+ +V C G+PTP + W KD L G L L G Y
Sbjct: 1513 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 1572
Query: 424 CEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKL 483
C+AS T+ L V P ++ A P + G V L C ARGHP P L
Sbjct: 1573 CKASNAVGAAEKATR---LDVYVPPTIEGAGGRPYVVKAVA-GRPVALECVARGHPSPTL 1628
Query: 484 SWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHG 529
SW G AE R S L L+ S SC AS+P G
Sbjct: 1629 SWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAG 1674
Score = 84.7 bits (208), Expect = 2e-16
Identities = 98/454 (21%), Positives = 170/454 (37%), Gaps = 62/454 (13%)
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
RSP +++ +G L + D Y+C+ + +AG+ L V +P A SP+
Sbjct: 3716 RSPRFEILPEGSLRIQPVLAQDAGHYLCLA-SNSAGSDRQGRDLRVL-EPPAIAPSPSNL 3773
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
TL+ + + C + +G+P P + W+++GQ+L+ ++ + S
Sbjct: 3774 TLTAHTPA---LLPCEA-SGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS----------- 3818
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
+ L L A F C + E RL T H+ + F V +
Sbjct: 3819 --NALLLTAPGPQDSAQFECVVSNEVGEAH--RLYQVTVHVPPTIADDQTDFTVTMMA-- 3872
Query: 278 AGWVREGDTVQLLCRGDGSPSPEYTLFRLQDE---QEEVLNVNLEGNLTLEGVTRGQSGT 334
V L C G P+P + + + + V+ G L + +G
Sbjct: 3873 --------PVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR 3924
Query: 335 YGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPAL 394
Y C + + T++ P+ V+ ++ C G+P P +
Sbjct: 3925 YTCSARNSAGVAHKHVFLTVQ-----ASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTI 3979
Query: 395 RWTKD--------STPLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQG 446
W K+ ST + G L ++ + + G Y+C A + +T+ L+VQ
Sbjct: 3980 TWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTR---LVVQV 4036
Query: 447 SPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQG----W 502
P ++ D S EG L C ARG P+P ++W + G +P+ G +G
Sbjct: 4037 PPVIENG----LPDLSTTEGSHAFLPCKARGSPEPNITWDKDG----QPVSGAEGKFTIQ 4088
Query: 503 VSSSLTLKVTSALSRDGISCEASNPHGNKRHVFH 536
S L +K +C A N G R H
Sbjct: 4089 PSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 4122
Score = 84.3 bits (207), Expect = 3e-16
Identities = 116/462 (25%), Positives = 179/462 (38%), Gaps = 68/462 (14%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSP--NKGTLSVMEDSAQ 167
L + A V D Y C AG +E LNV+ P V P TL+V E
Sbjct: 2126 LQVDRADVWDAGHYTCEA-LNQAGHSEKHYNLNVWVAP----VFPLRESHTLTVREGHPT 2180
Query: 168 EIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTST---LYL 224
++ C R G P PKI+W ++GQ L E +GL +++ LYL
Sbjct: 2181 SLS-CECR-GVPFPKISWRKDGQPLP----------------GEGAGLQHVSAVGRLLYL 2222
Query: 225 RLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREG 284
+ ++ ++ C + S L +H P + P T V++G
Sbjct: 2223 GQAQLAQEGTYTCECSNVVGNS------SQDLQLEVHVPPQIAG--PREPPTQVSVVQDG 2274
Query: 285 DTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEG---NLTLEGVTRGQSGTYGCRVED 341
L C G P P T R L + L+ +L +E +G Y C E+
Sbjct: 2275 -VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN 2333
Query: 342 YDAADDVQLSKTLELR---VAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK 398
+ + ++ + + LDPL ++ L+S + C G+P PA+RW +
Sbjct: 2334 LAGRAERKFELSVLVPPELIGDLDPLTN-----ITAALHSPLTLLCEAMGIPPPAIRWFR 2388
Query: 399 DSTPLGDGP---------MLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPE 449
P+ G ML ++ +G Y C AS +NF++ V P
Sbjct: 2389 GEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEA---RRNFSVEVLVPPS 2445
Query: 450 LKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVS-SSLT 508
++ ++E +G L+C+ GHP PKL+W + G A G +S +
Sbjct: 2446 IENEDLEEVI--KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR---GDAHHISPDGVL 2500
Query: 509 LKVTSA-LSRDG-ISCEASNPHGNKRHVFHFGTVSPQTSQAG 548
L+V A LS G SC A+N G K F + T G
Sbjct: 2501 LQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGG 2542
Score = 82.8 bits (203), Expect = 8e-16
Identities = 115/446 (25%), Positives = 165/446 (36%), Gaps = 73/446 (16%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEV--SPNKGTLSVMEDSAQ 167
L L A++ D Y C AAG + +L+V P + P L + D A
Sbjct: 2993 LQLGRARLSDSGMYTCEA-LNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKA- 3050
Query: 168 EIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLR 227
+ +C + + P P +TWY++GQ L L T L R
Sbjct: 3051 -VLSCET-DALPEPTVTWYKDGQPLV---------------------LAQRTQALRGGQR 3087
Query: 228 KDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTV 287
+ ++A YS TF LT+ P +P T G +
Sbjct: 3088 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFE-----NPKTETVSQVAGSPL 3142
Query: 288 QLLCRGDGSPSPEYTLF--RLQDEQEEVLNV-NLEGNLTLEGVTRGQSGTYGCRVEDYDA 344
L C G P+P T R+ E V V + G L L + Q+GTY C E+ A
Sbjct: 3143 VLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 3202
Query: 345 ADDVQLSKTLELRVAYLDPLELS----EGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDS 400
+ K + V + S E VL ++C G P P + W KD
Sbjct: 3203 ----EARKDFVVAVLVAPRIRSSGVAREHHVLE---GQEVRLDCEADGQPPPDVAWLKDG 3255
Query: 401 TPLG-----------DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPE 449
+PLG DG L L + G Y C A P +R +LV +
Sbjct: 3256 SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED-ARLHTVNVLVPPT-- 3312
Query: 450 LKTAEIEPKADGSW----REGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSS 505
I+ ADGS R G+ VT++C RG P +SW + G P P+ R S
Sbjct: 3313 -----IKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLK-DGLPL-PLSQRTLLHGS 3365
Query: 506 SLTLKVTSALSRDG--ISCEASNPHG 529
TL+++ D +C A++P G
Sbjct: 3366 GHTLRISKVQLADAGIFTCVAASPAG 3391
Score = 80.1 bits (196), Expect = 5e-15
Identities = 119/450 (26%), Positives = 173/450 (38%), Gaps = 85/450 (18%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEI 169
L + + + DE Y C AG ++ L V P + P +V+E+++ +
Sbjct: 1850 LQIEKVDLRDEGIYTCAA-TNLAGESKREVALKVLVPPN---IEPGPVNKAVLENASVTL 1905
Query: 170 ATCNSRNGNPAPKITWYRNGQRLE--VPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLR 227
S G P P ++W++ Q + + V ++ +G R +R LS
Sbjct: 1906 ECLAS--GVPPPDVSWFKGHQPVSSWMGVTVSVDG----RVLRIEQAQLS---------- 1949
Query: 228 KDDRDA-SFHCAAHY--SLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREG 284
DA S+ C A E R+G + +TL PS P G V
Sbjct: 1950 ----DAGSYRCVASNVAGSTELRYGLRVNVPPRITL------------PPSLP-GPVLVN 1992
Query: 285 DTVQLLCRGDGSPSPEYTLFRLQDEQ------EEVLNVNLEGN-LTLEGVTRGQSGTYGC 337
V+L C G+PSP TL L+D L V G LTL SG Y C
Sbjct: 1993 TPVRLTCNATGAPSP--TLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSC 2050
Query: 338 RVEDYDAAD--DVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALR 395
D DV L ++ P L E +S+ N S + C H +P P L
Sbjct: 2051 VAVSAVGEDRQDVVLQ-------VHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 2103
Query: 396 WTKDSTPLGDGPMLSLSS----ITFD-----SNGTYVCEASLPTVPVLSRTQNFTLLVQG 446
W KD PL P + LS+ + D G Y CEA +++ L V
Sbjct: 2104 WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA---LNQAGHSEKHYNLNVWV 2160
Query: 447 SPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVS-- 504
+P E + REG +L C RG P PK+SW + G +P+PG +
Sbjct: 2161 APVFPLRESHTL---TVREGHPTSLSCECRGVPFPKISWRKDG----QPLPGEGAGLQHV 2213
Query: 505 ---SSLTLKVTSALSRDG-ISCEASNPHGN 530
L + L+++G +CE SN GN
Sbjct: 2214 SAVGRLLYLGQAQLAQEGTYTCECSNVVGN 2243
Score = 77.8 bits (190), Expect = 3e-14
Identities = 115/477 (24%), Positives = 175/477 (36%), Gaps = 84/477 (17%)
Query: 102 YQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSV 161
Y L G L LA+ QVGD Y C + AG+A L V P +V P L V
Sbjct: 1076 YGLLPSGSLRLAQVQVGDSGHYECTA-SNPAGSASHRYVLGVQVPP---QVQPGPRVLKV 1131
Query: 162 MEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTST 221
+ A ++ C + GNP P+++W ++G L+ P+G S
Sbjct: 1132 LVGEALDL-NCVA-EGNPEPQLSWSKDGVVLQ---GRGPQG-----------------SV 1169
Query: 222 LYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWV 281
+ +R D A Y +D+ L + P W G+ T
Sbjct: 1170 HFAAIRTSD-------AGRYRCEASNSAGVDAWEVELRVLEPPH----W-GADETSGLLE 1217
Query: 282 R-EGDTVQLLCRGDGSPSPEYTLFRLQDEQEEV-----LNVNLEGNLTLEGVTRGQSGTY 335
R G+ L C G+P P+ T +R E + + V EG+L L V+ SG Y
Sbjct: 1218 RVAGENASLPCPARGTPKPQVT-WRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDY 1276
Query: 336 GCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLP--LNSSAVVNCSVHGLPTPA 393
C+ A ++V + V Y+ P +G+ ++ S + C +G P P
Sbjct: 1277 ECQ-----ATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPE 1331
Query: 394 LRWTKDS----TPLG--------------------DGPMLSLSSITFDSNGTYVCEASLP 429
+ W KD+ PLG +G L I +G Y C A
Sbjct: 1332 IVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQ 1391
Query: 430 TVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
+ ++F LLV P + A + G G +V L C G P P++ W++
Sbjct: 1392 AG---TAQRDFHLLVLTPPSVLGAGAAQEVLG--LAGADVELQCWTSGVPTPQVEWTK-D 1445
Query: 490 GSPAEPIPGRQGWVSSSLTLKVTSALSRD--GISCEASNPHGNKRHVFHFGTVSPQT 544
P P L++T + D C A +P G + F +P T
Sbjct: 1446 RQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 1502
Score = 76.6 bits (187), Expect = 6e-14
Identities = 118/470 (25%), Positives = 185/470 (39%), Gaps = 75/470 (15%)
Query: 99 SPPYQLDSQGR-LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
+P Q+ GR L LA A+ D Y CV A G L V P N
Sbjct: 2023 TPGLQVFPGGRVLTLASARASDSGRYSCVA-VSAVGEDRQDVVLQVHMPPSILGEELN-- 2079
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
+SV+ + + + C S + P P ++W+++G+ P+E P ++++
Sbjct: 2080 -VSVVANESVALE-CQS-HAMPPPVLSWWKDGR----PLEPRPGVHLSADKA-------- 2124
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
L + DR A A HY+ + H HY ++ WV +P P
Sbjct: 2125 --------LLQVDR-ADVWDAGHYTC------EALNQAGHSEKHY---NLNVWV-APVFP 2165
Query: 278 AG-----WVREGDTVQLLCRGDGSPSPEYTLFR----LQDEQEEVLNVNLEGNLTLEGVT 328
VREG L C G P P+ + + L E + +V+ G L G
Sbjct: 2166 LRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQA 2225
Query: 329 R-GQSGTYGCRVEDY--DAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCS 385
+ Q GTY C + +++ D+QL + ++A P E +S+ + A + C+
Sbjct: 2226 QLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA--GPRE--PPTQVSVVQDGVATLECN 2281
Query: 386 VHGLPTPALRWTKDSTPLG---------DGPMLSLSSITFDSNGTYVCEASLPTVPVLSR 436
G P P + W +D P+G G L + G Y C A + R
Sbjct: 2282 ATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE----NLAGR 2337
Query: 437 TQ-NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEP 495
+ F L V PEL +++P + + +TL+C A G P P + W + G P
Sbjct: 2338 AERKFELSVLVPPEL-IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR-GEEPVS- 2394
Query: 496 IPGRQGW-VSSSLTLKVTSALSRDG--ISCEASNPHGNKRHVFHFGTVSP 542
PG + ++ LK+T +D SC ASN G R F + P
Sbjct: 2395 -PGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP 2443
Score = 75.1 bits (183), Expect = 2e-13
Identities = 135/534 (25%), Positives = 196/534 (36%), Gaps = 84/534 (15%)
Query: 43 VMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPY 102
V+ G+ V LDC + G P + GS L M G +
Sbjct: 3229 VLEGQEVRLDC----------------EADGQPPPDVAWLKDGSPLGQDM----GPHLRF 3268
Query: 103 QLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVM 162
LD G LVL + D Y CV AG +NV P + + GTL V
Sbjct: 3269 YLDG-GSLVLKGLRASDAGAYTCVAH-NPAGEDARLHTVNVLVPPTIKQGADGSGTL-VS 3325
Query: 163 EDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTL 222
C R G+P ++W ++G L +P ++ RT+ SG S +
Sbjct: 3326 RPGELVTMVCPVR-GSPPIHVSWLKDG--LPLP--------LSQRTLLHGSGHTLRISKV 3374
Query: 223 YLRLRKDDRDAS-FHCAAHYSLPEGRHGRLDSPTFHLTLHYPT--EHVQFWVGSPSTPAG 279
L DA F C A + P G R F L + P E V+F
Sbjct: 3375 QLA------DAGIFTCVA--ASPAGVADR----NFTLQVQVPPVLEPVEFQNDVV----- 3417
Query: 280 WVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEG--NLTLEGVTRGQSGTYGC 337
V G V+L C G P P L + E +L+ +LE +L LE V G SGTY C
Sbjct: 3418 -VVRGSLVELPCEARGVPLP---LVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSC 3473
Query: 338 RVEDYDAADDVQLSKTLELR----VAYLDPLELSE-GKVLSLPLNSSAVVN--CSVHGLP 390
V +S+ E R + ++P + + G+ L L A + C G P
Sbjct: 3474 ----------VAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTP 3523
Query: 391 TPALRWTKDSTPLG--DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSP 448
P + W KD L + + + G Y C A P + ++F + VQ P
Sbjct: 3524 QPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAI---EKSFRVRVQAPP 3580
Query: 449 ELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLT 508
+ P+ G ++ L CS P PK++W + G E + L
Sbjct: 3581 NI-VGPRGPRFVVGLAPG-QLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQ 3638
Query: 509 LKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAVSVGLLL 562
L+ S SC A N G+ F + T ++G + V+V+ LL
Sbjct: 3639 LQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALL 3692
Score = 72.4 bits (176), Expect = 1e-12
Identities = 99/401 (24%), Positives = 155/401 (38%), Gaps = 64/401 (15%)
Query: 108 GRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMED--- 164
GRL L+ Q Y CV A +A AR + A V+P + V +
Sbjct: 3178 GRLQLSRLQPAQAGTYTCV-----AENTQAEARKDFVV---AVLVAPRIRSSGVAREHHV 3229
Query: 165 -SAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
QE+ +G P P + W ++G L + + Y+ G L L
Sbjct: 3230 LEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDG-------GSLVLKG--- 3279
Query: 224 LRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVRE 283
LR D A + C AH P G RL + + + P Q GS + + R
Sbjct: 3280 --LRASDAGA-YTCVAHN--PAGEDARLHT----VNVLVPPTIKQGADGSGTLVS---RP 3327
Query: 284 GDTVQLLCRGDGSPSPEYTLFR----LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGC-- 337
G+ V ++C GSP + + L Q +L+ + L + V +G + C
Sbjct: 3328 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGH-TLRISKVQLADAGIFTCVA 3386
Query: 338 ----RVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPA 393
V D + VQ+ LE V + + + + G ++ LP C G+P P
Sbjct: 3387 ASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELP--------CEARGVPLPL 3437
Query: 394 LRWTKDSTP-----LGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSP 448
+ W KD P L GP L L ++ +GTY C A ++F L V P
Sbjct: 3438 VSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVA---VSEAGEARRHFQLTVMEPP 3494
Query: 449 ELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
++ + + S G + L+C A+G P P ++W + G
Sbjct: 3495 HIE--DSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 3533
Score = 71.2 bits (173), Expect = 2e-12
Identities = 129/555 (23%), Positives = 205/555 (36%), Gaps = 78/555 (14%)
Query: 8 AQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDHYMLEWF 67
AQA R +A LA + + E+ + VPP E++ + + T H L
Sbjct: 2319 AQAAHTGRYSCVAENLAGRAERKFELSVLVPP--ELIGDLDPLTNIT-AALHSPLTL--- 2372
Query: 68 LTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVV 127
L + G P A +G E DT Y L L + + Q D Y C+
Sbjct: 2373 LCEAMGIPPP-AIRWFRGEEPVSPGEDT------YLLAGGWMLKMTQTQEQDSGLYSCLA 2425
Query: 128 RAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYR 187
+ AG A + V P + E + + V++ + CN G+P PK+TW++
Sbjct: 2426 -SNEAGEARRNFSVEVLVPP-SIENEDLEEVIKVLDGQTAHLM-CNV-TGHPQPKLTWFK 2481
Query: 188 NGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGR 247
+G+ L R + +S L L+ A+ A HYS
Sbjct: 2482 DGRPL----------------ARGDAHHISPDGVLLQVLQ-----ANLSSAGHYSCIAAN 2520
Query: 248 HGRLDSPTFHLT-LHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRL 306
+ F L+ L PT + + V + + L+C PSP T +
Sbjct: 2521 AVGEKTKHFQLSVLLAPT--ILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKD 2578
Query: 307 QDEQEEVLNVNL---EGNLTLEGVTRGQSGTYGCRVEDY--DAADDVQLSKTLELRVAYL 361
E N+ L L + + +G Y C V + +A + + + ++
Sbjct: 2579 GAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKD 2638
Query: 362 DPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTP---------LGDGPMLSLS 412
DPL K + +NS+ + C +P P +RW KD P LG+G +L +
Sbjct: 2639 DPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQ 2698
Query: 413 SITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTA-------EI---EPKADGS 462
+G Y+C A T Q+F +L+Q P + EI E +A G
Sbjct: 2699 PTQVSDSGRYLCVA---TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGG 2755
Query: 463 WREGDEVT------LICSARGHPDPKLSWSQLGG--SPAEPIPGRQGWVSSSLTLKVTSA 514
E E+ L C P P L+W + S + + QG L + + A
Sbjct: 2756 VTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQG--GRVLQIPLVRA 2813
Query: 515 LSRDGISCEASNPHG 529
+ SC+ASN G
Sbjct: 2814 ENAGRYSCKASNEVG 2828
Score = 67.0 bits (162), Expect = 5e-11
Identities = 126/520 (24%), Positives = 182/520 (35%), Gaps = 87/520 (16%)
Query: 38 PPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRG 97
P +V+ + G+ V L+C G H L W A + E GS L+
Sbjct: 1603 PYVVKAVAGRPVALECVARG-HPSPTLSWHHEGLPVAESNESRLETDGSVLR-------- 1653
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
L+S G EA G Y CV + AG A + V P+ V+ G
Sbjct: 1654 ------LESPG-----EASSGL---YSCVA-SSPAGEAVLQYSVEVQVPPQLL-VAEGLG 1697
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLE----VPVEMNPEGYMTSRTVREAS 213
++ + E+ C + +G+P P I W +NG+ E V V + S
Sbjct: 1698 QVTTIVGQPLELP-CQA-SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHS 1755
Query: 214 GLLSLTSTLYLRLRKDDRDASFH---CAAHYSLPEGRH--GRLDSPTFHLTLHYPTEHVQ 268
GL + +T + + S H +P G++ G +F P +
Sbjct: 1756 GLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVH--R 1813
Query: 269 FWVGSPSTPA--GWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEG 326
W P P GW G L G P + +L L +E
Sbjct: 1814 GWGAHPKPPLVEGWCSPGS---LWGEPTGIP----------------VAYSLPPPLQIEK 1854
Query: 327 VTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPL-NSSAVVNCS 385
V G Y C AA ++ E+ + L P + G V L N+S + C
Sbjct: 1855 VDLRDEGIYTC------AATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 1908
Query: 386 VHGLPTPALRWTKDSTPLG---------DGPMLSLSSITFDSNGTYVCEASLPTVPVLSR 436
G+P P + W K P+ DG +L + G+Y C AS V
Sbjct: 1909 ASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVAS----NVAGS 1964
Query: 437 TQ-NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEP 495
T+ + L V P + + P G V L C+A G P P L W + G+P P
Sbjct: 1965 TELRYGLRVNVPPRI---TLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK-DGNPVSP 2020
Query: 496 --IPGRQGWVSSS-LTLKVTSALSRDGISCEASNPHGNKR 532
PG Q + LTL A SC A + G R
Sbjct: 2021 AGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDR 2060
Score = 66.2 bits (160), Expect = 8e-11
Identities = 94/432 (21%), Positives = 158/432 (36%), Gaps = 61/432 (14%)
Query: 75 RPRLASAEMQGS---ELQVTMHDTR-GRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAG 130
+P L S + + LQ+ + R G +Q + A +E Y C
Sbjct: 442 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTA-VS 500
Query: 131 AAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAP-KITWYRNG 189
AGT A A++ V P +PN + S E A + R AP +TW R+
Sbjct: 501 RAGTGRAKAQIVVTDPPPQLVPAPN------VTVSPGETAVLSCRVLGEAPYNLTWVRDW 554
Query: 190 QRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHG 249
+ L P + ++ E SG++ Y C A +G
Sbjct: 555 RVL--PASTGRVAQLADLSL-EISGIIPTDGGRY------------QCVA-----SNANG 594
Query: 250 RLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQD- 308
+ + L P + T + +G V++ C G P+P + R
Sbjct: 595 VTRASVWLLVREAPQVSIH-------TSSQHFSQGVEVKVSCSASGYPTPHISWSRESQA 647
Query: 309 -EQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELS 367
+++ ++V+ +G L ++GV +G Y C+ + D ++ + Y DP +S
Sbjct: 648 LQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVT------LYYTDPPSVS 701
Query: 368 E-GKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGP------MLSLSSITFDSNG 420
V+ + + AV+ C G+P P + W + + P L + + G
Sbjct: 702 AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAG 761
Query: 421 TYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPD 480
TY C A + Q L V +P+L E D + G L C A G P
Sbjct: 762 TYTCRAVNELGDASAEIQ---LAVGHAPQL----TELPRDVTVELGRSALLACRATGRPP 814
Query: 481 PKLSWSQLGGSP 492
P ++W + G P
Sbjct: 815 PTVTWRRGDGQP 826
Score = 65.9 bits (159), Expect = 1e-10
Identities = 109/474 (22%), Positives = 163/474 (34%), Gaps = 67/474 (14%)
Query: 103 QLDSQGRLV-LAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSV 161
Q+ +GRL+ + QV D Y+CV AG + + + P +V +
Sbjct: 2687 QVLGEGRLLQIQPTQVSDSGRYLCVA-TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEI 2745
Query: 162 M--EDSAQ-------EIATCN------SRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTS 206
+ E+ A+ EI N N P P +TWYR Q L E++
Sbjct: 2746 LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVS------- 2798
Query: 207 RTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEH 266
+L L + L + + + C A + E H L T
Sbjct: 2799 --------VLQGGRVLQIPLVRAENAGRYSCKASNEVGED--------WLHYELLVLTPP 2842
Query: 267 VQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFR--LQDEQEEVLNVNLEGN-LT 323
V V TV L C G+P P + + L L V +G L
Sbjct: 2843 VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQ 2902
Query: 324 LEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVN 383
+ + +Y C E+ + + K LRV + + + ++ LNSS +
Sbjct: 2903 VSTAEVADAASYMCVAENQAGSAE----KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLP 2958
Query: 384 CSVHGLPTPALRWTKDSTPLGDGP---------MLSLSSITFDSNGTYVCEASLPTVPVL 434
C VH P P + W KDS L G L L +G Y CEA +
Sbjct: 2959 CDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEA----LNAA 3014
Query: 435 SRTQNFT-LLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSP- 492
R Q L V P + A P+ R GD+ L C P+P ++W + G P
Sbjct: 3015 GRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK-DGQPL 3073
Query: 493 --AEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQT 544
A+ +G L ++ + SC+ SN G F P T
Sbjct: 3074 VLAQRTQALRG--GQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPT 3125
Score = 65.9 bits (159), Expect = 1e-10
Identities = 128/546 (23%), Positives = 189/546 (34%), Gaps = 86/546 (15%)
Query: 7 PAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDHYMLEW 66
P A+ A L LA A ++R+ PP + + TP
Sbjct: 3732 PVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPA---------L 3782
Query: 67 FLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCV 126
+ SG+ L G +L D R + Y+L L+L D + CV
Sbjct: 3783 LPCEASGSPKPLVVWWKDGQKL-----DFRLQQGAYRLLPSNALLLTAPGPQDSAQFECV 3837
Query: 127 VRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWY 186
V + G A ++ V P + T+++M A + TC+S G PAP ++W
Sbjct: 3838 V-SNEVGEAHRLYQVTVHVPPTIAD-DQTDFTVTMM---APVVLTCHS-TGIPAPTVSWS 3891
Query: 187 RNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEG 246
+ G +L GY S SG L + L + + + C+A S
Sbjct: 3892 KAGAQLGA----RGSGYRVS-----PSGALEIGQALPIHAGR------YTCSARNS---- 3932
Query: 247 RHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRL 306
+ H + + PS E V L C G P P T
Sbjct: 3933 ------AGVAHKHVFLTVQASPVVKPLPSVVRAVAEE--EVLLPCEASGIPRPTITW--- 3981
Query: 307 QDEQEEVLNVNLE--------GNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRV 358
Q+E LNV G L + + +G Y C ++ + + KT R+
Sbjct: 3982 ---QKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS---AMGKT---RL 4032
Query: 359 AYLDPLELSEGKV-LSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGP---------M 408
P + G LS S A + C G P P + W KD P+
Sbjct: 4033 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE 4092
Query: 409 LSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDE 468
L + ++ GTY C A V R + T+LV P T D S R GD
Sbjct: 4093 LLVKNLEGQDAGTYTCTAE-NAVGRARRRVHLTILVL--PVFTTLP----GDRSLRLGDR 4145
Query: 469 VTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPH 528
+ L C+ARG P P++ W+ E + + G S+L S C A N
Sbjct: 4146 LWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG--GSTLQRAAVSREDSGTYVCWAENRV 4203
Query: 529 GNKRHV 534
G + V
Sbjct: 4204 GRTQAV 4209
Score = 65.5 bits (158), Expect = 1e-10
Identities = 111/434 (25%), Positives = 163/434 (37%), Gaps = 79/434 (18%)
Query: 123 YVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPK 182
Y CV + A G A+ L V EA +VS + T S E+ S +G P P
Sbjct: 585 YQCVA-SNANGVTRASVWLLV---REAPQVSIH--TSSQHFSQGVEVKVSCSASGYPTPH 638
Query: 183 ITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYS 242
I+W R Q L+ SR +A G L + + +D A +YS
Sbjct: 639 ISWSRESQALQED----------SRIHVDAQGTLIIQG-----VAPED-------AGNYS 676
Query: 243 LPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAG----WVREGDTVQLLCRGDGSPS 298
D T +TL+Y PS A V G+ L+C G P
Sbjct: 677 CQATNEVGTDQET--VTLYY--------TDPPSVSAVNAVVLVAVGEEAVLVCEASGVPP 726
Query: 299 PEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRV--EDYDAADDVQLSKTLEL 356
P +R E + G L + +GTY CR E DA+ ++QL+
Sbjct: 727 PRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP 786
Query: 357 RVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK-DSTPLG----------- 404
++ L + +++ L SA++ C G P P + W + D PLG
Sbjct: 787 QLTELP-------RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRS 839
Query: 405 ---DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQ-NFTLLVQGSPELKTAEIEPKAD 460
D +L S+ + YVCEA V + Q L+V G + A P
Sbjct: 840 RQPDSGVLFFESVAPEDQAPYVCEAR----NVFGKVQAEARLIVTGHAPPQIASSAPTV- 894
Query: 461 GSWREGDEVTLICSA-RGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDG 519
EG V+L C G P P+ W + G P PG + + + +L + AL
Sbjct: 895 -RVLEGQPVSLPCIVLAGRPLPERHWLK-DGRPLP--PGSRHSIRADGSLHLDRALQEHA 950
Query: 520 --ISCEASNPHGNK 531
SC A+N G++
Sbjct: 951 GRYSCVATNTAGSQ 964
Score = 65.5 bits (158), Expect = 1e-10
Identities = 113/458 (24%), Positives = 172/458 (37%), Gaps = 52/458 (11%)
Query: 116 QVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSR 175
+V D Y C+ + AG E + R+ V A P V P V Q + C S
Sbjct: 3550 RVRDAGLYTCLAES-PAGAIEKSFRVRVQAPPNI--VGPRGPRFVVGLAPGQLVLEC-SV 3605
Query: 176 NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASF 235
PAPKITW+R+G L+ E T R L ST D D S
Sbjct: 3606 EAEPAPKITWHRDGIVLQ-------EDAHTQFPERGRFLQLQALSTA------DSGDYS- 3651
Query: 236 HCAAHYSLPEGRHGRLDSPTFHLTLH-YPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGD 294
C A + S F + +H PT PA V T L C+ D
Sbjct: 3652 -CTARNAAGS------TSVAFRVEIHTVPTIR-------SGPPAVNVSVNQTALLPCQAD 3697
Query: 295 GSPSPEYTLFRLQ---DEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLS 351
G P+P + + + D + + EG+L ++ V +G Y C + +D
Sbjct: 3698 GVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD----R 3753
Query: 352 KTLELRVAYLDPLELSEG-KVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPL------G 404
+ +LRV L+P ++ L+L ++ A++ C G P P + W KD L G
Sbjct: 3754 QGRDLRV--LEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQG 3811
Query: 405 DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWR 464
+L +++ + G +++ V + L Q + + + + D +
Sbjct: 3812 AYRLLPSNALLLTAPGPQ--DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVT 3869
Query: 465 EGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEA 524
V L C + G P P +SWS+ G G + S +L + + +C A
Sbjct: 3870 MMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSA 3929
Query: 525 SNPHG-NKRHVFHFGTVSPQTSQAGVAVMAVAVSVGLL 561
N G +HVF SP V AVA LL
Sbjct: 3930 RNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 3967
Score = 62.8 bits (151), Expect = 9e-10
Identities = 115/485 (23%), Positives = 176/485 (36%), Gaps = 108/485 (22%)
Query: 28 DAQAEVRLSVPPLVE---------VMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRL 78
D +++ VPP++E V+RG V L C G ++ W P L
Sbjct: 3394 DRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGV-PLPLVSWM----KDGEPLL 3448
Query: 79 ASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEAT 138
+ + QG P QL++ G GD Y CV AG A
Sbjct: 3449 SQSLEQG--------------PSLQLEAVG--------AGDSGTYSCVA-VSEAGEARRH 3485
Query: 139 ARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEM 198
+L V P E S LS+ + E+ C+++ G P P ITW+++GQ L +E
Sbjct: 3486 FQLTVMEPPHI-EDSGQPTELSLTPGAPMELL-CDAQ-GTPQPNITWHKDGQAL-TRLEN 3541
Query: 199 NPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHL 258
N +T LR+R DA + L E G ++ +F +
Sbjct: 3542 NSR------------------ATRVLRVR----DAGLYTC----LAESPAGAIEK-SFRV 3574
Query: 259 TLHYPTEHV-----QFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEV 313
+ P V +F VG + G V L C + P+P+ T R +E
Sbjct: 3575 RVQAPPNIVGPRGPRFVVG--------LAPGQLV-LECSVEAEPAPKITWHRDGIVLQED 3625
Query: 314 LNVNLEGN---LTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGK 370
+ L L+ ++ SG Y C + AA ++ +E+ P S
Sbjct: 3626 AHTQFPERGRFLQLQALSTADSGDYSCTARN--AAGSTSVAFRVEIHTV---PTIRSGPP 3680
Query: 371 VLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGP---------MLSLSSITFDSNGT 421
+++ +N +A++ C G+P P + W KD PL L + + G
Sbjct: 3681 AVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 3740
Query: 422 YVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLI-CSARGHPD 480
Y+C AS S Q L V L+ I P L+ C A G P
Sbjct: 3741 YLCLASNSAG---SDRQGRDLRV-----LEPPAIAPSPSNLTLTAHTPALLPCEASGSPK 3792
Query: 481 PKLSW 485
P + W
Sbjct: 3793 PLVVW 3797
Score = 61.2 bits (147), Expect = 3e-09
Identities = 107/448 (23%), Positives = 165/448 (36%), Gaps = 68/448 (15%)
Query: 125 CVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIAT--CNSRNGNPAPK 182
CV A T T N +GTL + + SAQ+ C + N
Sbjct: 997 CVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN------ 1050
Query: 183 ITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYS 242
T + Q + + V S+ V E GLL S +++ D + HY
Sbjct: 1051 -TVGFSSQEMRLSVNR----LALSKYVWEEYGLLPSGSLRLAQVQVGD-------SGHYE 1098
Query: 243 LPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYT 302
S + L + P + VQ P V G+ + L C +G+P P+ +
Sbjct: 1099 CTASNPAGSASHRYVLGVQVPPQ-VQ-----PGPRVLKVLVGEALDLNCVAEGNPEPQLS 1152
Query: 303 LFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLD 362
+ + + +G++ + +G Y C + D ++ ELRV L+
Sbjct: 1153 WSK---DGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEV----ELRV--LE 1203
Query: 363 PLELSEGK---VLSLPLNSSAVVNCSVHGLPTPALRWTK--DSTPLGDGP--------ML 409
P + +L +A + C G P P + W K S PL P L
Sbjct: 1204 PPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSL 1263
Query: 410 SLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEV 469
L+S++ +G Y C+A T V S ++ L+V P ++ E KA+ S G +
Sbjct: 1264 FLASVSPADSGDYECQA---TNEVGSTSRRAKLVVYVPPSIR--EDGRKANVSGMAGQSL 1318
Query: 470 TLICSARGHPDPKLSW---SQLGGSPA--EPIPGRQGW--VSSSLTLKVTSALSRDGI-- 520
TL C A G P P++ W +QL G P GW V L +L I
Sbjct: 1319 TLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQE 1378
Query: 521 ------SCEASNPHGNKRHVFHFGTVSP 542
SC A N G + FH ++P
Sbjct: 1379 GDSGLYSCRAENQAGTAQRDFHLLVLTP 1406
Score = 59.7 bits (143), Expect = 7e-09
Identities = 121/490 (24%), Positives = 181/490 (36%), Gaps = 110/490 (22%)
Query: 106 SQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDS 165
S G+L + AQ D Y C G A A +L V P+ TE+ P T+ + +
Sbjct: 746 SSGKLRIPAAQERDAGTYTCRA-VNELGDASAEIQLAVGHAPQLTEL-PRDVTVELGRSA 803
Query: 166 AQEIATCNSRNGNPAPKITWYR-NGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYL 224
+ C + G P P +TW R +GQ P+ + SR+ + SG+L S
Sbjct: 804 ---LLACRA-TGRPPPTVTWRRGDGQ----PLGLRLGAGRGSRSRQPDSGVLFFESVA-- 853
Query: 225 RLRKDDRDASFHCAAHYSLPEGRHGRLDSPT-FHLTLHYPTEHVQFWVGSPSTPAGWVRE 283
+ A + C A G++ + +T H P + S P V E
Sbjct: 854 ----PEDQAPYVCEARNVF-----GKVQAEARLIVTGHAPPQIAS------SAPTVRVLE 898
Query: 284 GDTVQLLCRG-DGSPSPEYTLFRLQDEQE----EVLNVNLEGNLTLEGVTRGQSGTYGCR 338
G V L C G P PE L+D + ++ +G+L L+ + +G Y C
Sbjct: 899 GQPVSLPCIVLAGRPLPERHW--LKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCV 956
Query: 339 VEDYDAAD--DVQLSKTLELRVAYLDPLELS-EGKVLSLPLNSSAVVNCSVHGLPTPALR 395
+ + DV+L + R+ ++ EG SLP C G+P P +
Sbjct: 957 ATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLP--------CVASGVPAPTIT 1008
Query: 396 WTKDSTPL-GDGP--------MLSLSSITFDSNGTYVCEASLPTVPVLSRT--------- 437
WTK++ L GP L ++ + G YVC A+ TV S+
Sbjct: 1009 WTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTAT-NTVGFSSQEMRLSVNRLA 1067
Query: 438 ------QNFTLLVQGSPELKTAEI-----------EPKADGSWR---------------- 464
+ + LL GS L ++ P S R
Sbjct: 1068 LSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPR 1127
Query: 465 -----EGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDG 519
G+ + L C A G+P+P+LSWS+ G + GR S TS R
Sbjct: 1128 VLKVLVGEALDLNCVAEGNPEPQLSWSKDG----VVLQGRGPQGSVHFAAIRTSDAGR-- 1181
Query: 520 ISCEASNPHG 529
CEASN G
Sbjct: 1182 YRCEASNSAG 1191
Score = 50.4 bits (119), Expect = 4e-06
Identities = 60/250 (24%), Positives = 102/250 (40%), Gaps = 26/250 (10%)
Query: 328 TRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVH 387
++ + GTY C A + V P +L +++ +AV++C V
Sbjct: 487 SKAEEGTYECT-----AVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 541
Query: 388 GLPTPALRWTKD--STPLGDGPMLSLSSITFD-------SNGTYVCEASLPTVPVLSRTQ 438
G L W +D P G + L+ ++ + G Y C AS ++R
Sbjct: 542 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVAS--NANGVTRAS 599
Query: 439 NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPG 498
+ LLV+ +P++ + + +G EV + CSA G+P P +SWS+ + E
Sbjct: 600 VW-LLVREAPQVSIHT----SSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQE---D 651
Query: 499 RQGWVSSSLTLKVTSALSRD--GISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAV 556
+ V + TL + D SC+A+N G + P + A AV+ VAV
Sbjct: 652 SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV 711
Query: 557 SVGLLLLVVA 566
+L+ A
Sbjct: 712 GEEAVLVCEA 721
Score = 50.4 bits (119), Expect = 4e-06
Identities = 83/368 (22%), Positives = 135/368 (36%), Gaps = 62/368 (16%)
Query: 97 GRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNK 156
G + + G L++ + D Y C A G A L + P T + P
Sbjct: 4080 GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE-NAVGRARRRVHLTILVLPVFTTL-PGD 4137
Query: 157 GTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTV--REASG 214
+L + + + C +R G+P P+I W N + + V G R RE SG
Sbjct: 4138 RSLRLGD---RLWLRCAAR-GSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSG 4193
Query: 215 LLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSP 274
++ C A E R GR + +F HV+
Sbjct: 4194 -------------------TYVCWA-----ENRVGRTQAVSF--------VHVKEAPVLQ 4221
Query: 275 STPAGWVRE--GDTVQLLC--RGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRG 330
++ E G ++QL C RGD P + L + + G+LT+ R
Sbjct: 4222 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERD 4281
Query: 331 QSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLP 390
+G Y C E+ ++ ++K + + V P+ E + +++ + C G P
Sbjct: 4282 DAGRYQCLAEN-----EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP 4336
Query: 391 TPALRWTKDSTP---------LGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFT 441
TP + W + P L DG L L ++ GTY C A + S T
Sbjct: 4337 TPTIEWLQAGQPLRASRRLRTLPDG-SLWLENVETGDAGTYDCVAH---NLLGSATARAF 4392
Query: 442 LLVQGSPE 449
L+V+G P+
Sbjct: 4393 LVVRGEPQ 4400
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 101 bits (252), Expect = 2e-21
Identities = 122/479 (25%), Positives = 188/479 (39%), Gaps = 62/479 (12%)
Query: 99 SPPYQLDSQGRLV-LAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
SP Q+ G+++ ++ A+V D Y+CV AG+AE L V P + +
Sbjct: 1607 SPRLQVLEDGQVLQVSTAEVADAASYMCVAE-NQAGSAEKLFTLRVQVPPRIAGLDLEQV 1665
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
T +++ S C+ + +P P++TWY++ Q L + E+ LL
Sbjct: 1666 T-AILNSSVS--LPCDV-HAHPNPEVTWYKDSQALSLGEEVF---------------LLP 1706
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
T TL L + + C A + GR D L++ P Q +P P
Sbjct: 1707 GTHTLQLGRARLSDSGMYTCEALNAA-----GR-DQKLVQLSVLVPPAFRQ----APRGP 1756
Query: 278 --AGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEG-----NLTLEGVTRG 330
A VR GD L C D P P T ++ D Q VL + L ++
Sbjct: 1757 QDAVLVRVGDKAVLSCETDALPEPTVTWYK--DGQPLVLAQRTQALRGGQRLEIQEAQVS 1814
Query: 331 QSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLP 390
G Y C+V + + T+++ + +P + +V PL V+ C V G+P
Sbjct: 1815 DKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPL----VLTCDVSGVP 1870
Query: 391 TPALRWTKDSTP---------LGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFT 441
P + W KD P + G L LS + GTY C A ++F
Sbjct: 1871 APTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA---EARKDFV 1927
Query: 442 LLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPG--- 498
+ V +P ++++ + + EG EV L C A G P P ++W + GSP G
Sbjct: 1928 VAVLVAPRIRSSGV--AREHHVLEGQEVRLDCEADGQPPPDVAWLK-DGSPLGQDMGPHL 1984
Query: 499 RQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAVS 557
R SL LK A +C A NP G + + P T + G VS
Sbjct: 1985 RFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVS 2043
Score = 93.6 bits (231), Expect = 5e-19
Identities = 104/395 (26%), Positives = 166/395 (42%), Gaps = 61/395 (15%)
Query: 108 GRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQ 167
G+L +A A D +Y+C+ + +AG+A RL V P P+ T + +
Sbjct: 2718 GQLRIAHASPEDAGNYLCIAK-NSAGSAMGKTRLVVQVPPVIENGLPDLSTT----EGSH 2772
Query: 168 EIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLR 227
C +R G+P P ITW ++GQ PV EG T + E L ++
Sbjct: 2773 AFLPCKAR-GSPEPNITWDKDGQ----PVS-GAEGKFTIQPSGE----------LLVKNL 2816
Query: 228 KDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTV 287
+ ++ C A ++ R HLT+ + + P + +R GD +
Sbjct: 2817 EGQDAGTYTCTAENAVGRARR------RVHLTILV----LPVFTTLPGDRS--LRLGDRL 2864
Query: 288 QLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLE--GVTRGQSGTYGCRVEDYDAA 345
L C GSP+P + + D +G TL+ V+R SGTY C E+
Sbjct: 2865 WLRCAARGSPTPRIG-WTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN---- 2919
Query: 346 DDVQLSKTLELRVAYLDPLELSEGKVLSL---PLNSSAVVNCSVHGLPTPALRWTKDSTP 402
++ +T + ++ + +G+ S P+ S ++C V G P P + W KD P
Sbjct: 2920 ---RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 2976
Query: 403 LGDGPM---LSLSSITF-----DSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAE 454
L + L S+T D G Y C A + V + L++Q +P +
Sbjct: 2977 LRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAE-NEMGVAKKV--VILVLQSAPVF---Q 3030
Query: 455 IEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
+EP+ D + R GD+V L C A G P P + W Q G
Sbjct: 3031 VEPQ-DMTVRSGDDVALRCQATGEPTPTIEWLQAG 3064
Score = 86.3 bits (212), Expect = 7e-17
Identities = 115/442 (26%), Positives = 168/442 (38%), Gaps = 55/442 (12%)
Query: 104 LDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVME 163
LD L Q GD Y C AGTA+ L V P + L +
Sbjct: 83 LDEGQSLHFPRIQEGDSGLYSCRAE-NQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGL-- 139
Query: 164 DSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
+ ++ +G P P++ W ++ Q + P G V+E +L +T +
Sbjct: 140 -AGADVELQCWTSGVPTPQVEWTKDRQ------PVLPGG--PHLQVQEDGQVLRITGSHV 190
Query: 224 LRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVRE 283
+ + C A P G+ R F L +H P W GS T V E
Sbjct: 191 ------GDEGRYQCVAFS--PAGQQAR----DFQLRVHAPPT---IW-GSNETGEVAVME 234
Query: 284 GDTVQLLCRGDGSPSPEYTLFR---LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVE 340
VQLLC G P+P T F+ L +V+ L L +G Y C+
Sbjct: 235 DHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKAS 294
Query: 341 DYDAADDVQLSKTLELRVAYLDPLELSEGK--VLSLPLNSSAVVNCSVHGLPTPALRWTK 398
+ A + K L V +E + G+ V+ + C G P+P L W
Sbjct: 295 NAVGAAE----KATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHH 350
Query: 399 DSTPLG---------DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPE 449
+ P+ DG +L L S S+G Y C AS P + + +++ VQ P+
Sbjct: 351 EGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ---YSVEVQVPPQ 407
Query: 450 LKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTL 509
L AE + G + L C A G P P + W Q G PAE + G Q S TL
Sbjct: 408 LLVAE--GLGQVTTIVGQPLELPCQASGSPVPTIQWLQ-NGRPAEELAGVQ-VASQGTTL 463
Query: 510 KVTSA-LSRDGI-SCEASNPHG 529
+ L G+ +C+A+N G
Sbjct: 464 HIDHVELDHSGLFACQATNEAG 485
Score = 84.7 bits (208), Expect = 2e-16
Identities = 98/454 (21%), Positives = 170/454 (37%), Gaps = 62/454 (13%)
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
RSP +++ +G L + D Y+C+ + +AG+ L V +P A SP+
Sbjct: 2434 RSPRFEILPEGSLRIQPVLAQDAGHYLCLA-SNSAGSDRQGRDLRVL-EPPAIAPSPSNL 2491
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
TL+ + + C + +G+P P + W+++GQ+L+ ++ + S
Sbjct: 2492 TLTAHTPA---LLPCEA-SGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS----------- 2536
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
+ L L A F C + E RL T H+ + F V +
Sbjct: 2537 --NALLLTAPGPQDSAQFECVVSNEVGEAH--RLYQVTVHVPPTIADDQTDFTVTMMA-- 2590
Query: 278 AGWVREGDTVQLLCRGDGSPSPEYTLFRLQDE---QEEVLNVNLEGNLTLEGVTRGQSGT 334
V L C G P+P + + + + V+ G L + +G
Sbjct: 2591 --------PVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR 2642
Query: 335 YGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPAL 394
Y C + + T++ P+ V+ ++ C G+P P +
Sbjct: 2643 YTCSARNSAGVAHKHVFLTVQ-----ASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTI 2697
Query: 395 RWTKD--------STPLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQG 446
W K+ ST + G L ++ + + G Y+C A + +T+ L+VQ
Sbjct: 2698 TWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTR---LVVQV 2754
Query: 447 SPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQG----W 502
P ++ D S EG L C ARG P+P ++W + G +P+ G +G
Sbjct: 2755 PPVIENG----LPDLSTTEGSHAFLPCKARGSPEPNITWDKDG----QPVSGAEGKFTIQ 2806
Query: 503 VSSSLTLKVTSALSRDGISCEASNPHGNKRHVFH 536
S L +K +C A N G R H
Sbjct: 2807 PSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 2840
Score = 84.3 bits (207), Expect = 3e-16
Identities = 116/462 (25%), Positives = 179/462 (38%), Gaps = 68/462 (14%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSP--NKGTLSVMEDSAQ 167
L + A V D Y C AG +E LNV+ P V P TL+V E
Sbjct: 844 LQVDRADVWDAGHYTCEA-LNQAGHSEKHYNLNVWVAP----VFPLRESHTLTVREGHPT 898
Query: 168 EIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTST---LYL 224
++ C R G P PKI+W ++GQ L E +GL +++ LYL
Sbjct: 899 RLS-CECR-GVPFPKISWRKDGQPLP----------------GEGAGLQHVSAVGRLLYL 940
Query: 225 RLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREG 284
+ ++ ++ C + S L +H P + P T V++G
Sbjct: 941 GQAQLAQEGTYTCECSNVVGNS------SQDLQLEVHVPPQIAG--PREPPTQVSVVQDG 992
Query: 285 DTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEG---NLTLEGVTRGQSGTYGCRVED 341
L C G P P T R L + L+ +L +E +G Y C E+
Sbjct: 993 -VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN 1051
Query: 342 YDAADDVQLSKTLELR---VAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK 398
+ + ++ + + LDPL ++ L+S + C G+P PA+RW +
Sbjct: 1052 LAGRAERKFELSVLVPPELIGDLDPLTN-----ITAALHSPLTLLCEAMGIPPPAIRWFR 1106
Query: 399 DSTPLGDGP---------MLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPE 449
P+ G ML ++ +G Y C AS +NF++ V P
Sbjct: 1107 GEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEA---RRNFSVEVLVPPS 1163
Query: 450 LKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVS-SSLT 508
++ ++E +G L+C+ GHP PKL+W + G A G +S +
Sbjct: 1164 IENEDLEEVI--KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR---GDAHHISPDGVL 1218
Query: 509 LKVTSA-LSRDG-ISCEASNPHGNKRHVFHFGTVSPQTSQAG 548
L+V A LS G SC A+N G K F + T G
Sbjct: 1219 LQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGG 1260
Score = 82.8 bits (203), Expect = 8e-16
Identities = 115/446 (25%), Positives = 165/446 (36%), Gaps = 73/446 (16%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEV--SPNKGTLSVMEDSAQ 167
L L A++ D Y C AAG + +L+V P + P L + D A
Sbjct: 1711 LQLGRARLSDSGMYTCEA-LNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKA- 1768
Query: 168 EIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLR 227
+ +C + + P P +TWY++GQ L L T L R
Sbjct: 1769 -VLSCET-DALPEPTVTWYKDGQPLV---------------------LAQRTQALRGGQR 1805
Query: 228 KDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTV 287
+ ++A YS TF LT+ P +P T G +
Sbjct: 1806 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFE-----NPKTETVSQVAGSPL 1860
Query: 288 QLLCRGDGSPSPEYTLF--RLQDEQEEVLNV-NLEGNLTLEGVTRGQSGTYGCRVEDYDA 344
L C G P+P T R+ E V V + G L L + Q+GTY C E+ A
Sbjct: 1861 VLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 1920
Query: 345 ADDVQLSKTLELRVAYLDPLELS----EGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDS 400
+ K + V + S E VL ++C G P P + W KD
Sbjct: 1921 ----EARKDFVVAVLVAPRIRSSGVAREHHVLE---GQEVRLDCEADGQPPPDVAWLKDG 1973
Query: 401 TPLG-----------DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPE 449
+PLG DG L L + G Y C A P +R +LV +
Sbjct: 1974 SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED-ARLHTVNVLVPPT-- 2030
Query: 450 LKTAEIEPKADGSW----REGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSS 505
I+ ADGS R G+ VT++C RG P +SW + G P P+ R S
Sbjct: 2031 -----IKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLK-DGLPL-PLSQRTLLHGS 2083
Query: 506 SLTLKVTSALSRDG--ISCEASNPHG 529
TL+++ D +C A++P G
Sbjct: 2084 GHTLRISKVQLADAGIFTCVAASPAG 2109
Score = 79.3 bits (194), Expect = 9e-15
Identities = 119/450 (26%), Positives = 172/450 (38%), Gaps = 85/450 (18%)
Query: 110 LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEI 169
L + + + DE Y C AG ++ L V P + P +V+E+++ +
Sbjct: 568 LQIEKVDLRDEGIYTCAA-TNLAGESKREVALKVLVPPN---IEPGPVNKAVLENASVTL 623
Query: 170 ATCNSRNGNPAPKITWYRNGQRLE--VPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLR 227
S G P P ++W++ Q + + V ++ +G R +R LS
Sbjct: 624 ECLAS--GVPPPDVSWFKGHQPVSSWMGVTVSVDG----RVLRIEQAQLS---------- 667
Query: 228 KDDRDA-SFHCAAHY--SLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREG 284
DA S+ C A E R+G + +TL PS P G V
Sbjct: 668 ----DAGSYRCVASNVAGSTELRYGLRVNVPPRITL------------PPSLP-GPVLVN 710
Query: 285 DTVQLLCRGDGSPSPEYTLFRLQDEQEEV------LNVNLEGN-LTLEGVTRGQSGTYGC 337
V+L C G+PSP TL L+D L V G LTL SG Y C
Sbjct: 711 TPVRLTCNATGAPSP--TLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSC 768
Query: 338 RVEDYDAAD--DVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALR 395
D DV L ++ P L E +S+ N S + C H +P P L
Sbjct: 769 VAVSAVGEDRQDVVLQ-------VHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 821
Query: 396 WTKDSTPLGDGPMLSLSS----ITFD-----SNGTYVCEASLPTVPVLSRTQNFTLLVQG 446
W KD PL P + LS+ + D G Y CEA +++ L V
Sbjct: 822 WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA---LNQAGHSEKHYNLNVWV 878
Query: 447 SPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVS-- 504
+P E + REG L C RG P PK+SW + G +P+PG +
Sbjct: 879 APVFPLRESHTL---TVREGHPTRLSCECRGVPFPKISWRKDG----QPLPGEGAGLQHV 931
Query: 505 ---SSLTLKVTSALSRDG-ISCEASNPHGN 530
L + L+++G +CE SN GN
Sbjct: 932 SAVGRLLYLGQAQLAQEGTYTCECSNVVGN 961
Score = 77.0 bits (188), Expect = 4e-14
Identities = 118/470 (25%), Positives = 186/470 (39%), Gaps = 75/470 (15%)
Query: 99 SPPYQLDSQGR-LVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
+P Q+ GR L LA A+ D Y CV A G L V P N
Sbjct: 741 TPGLQVFPGGRVLTLASARASDSGRYSCVA-VSAVGEDRQDVVLQVHMPPSILGEELN-- 797
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
+SV+ + + + C S + P P ++W+++G+ P+E P ++++
Sbjct: 798 -VSVVANESVALE-CQS-HAMPPPVLSWWKDGR----PLEPRPGVHLSADKA-------- 842
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
L + DR A A HY+ + H HY ++ WV +P P
Sbjct: 843 --------LLQVDR-ADVWDAGHYTC------EALNQAGHSEKHY---NLNVWV-APVFP 883
Query: 278 AG-----WVREGDTVQLLCRGDGSPSPEYTLFR----LQDEQEEVLNVNLEGNLTLEGVT 328
VREG +L C G P P+ + + L E + +V+ G L G
Sbjct: 884 LRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQA 943
Query: 329 R-GQSGTYGCRVEDY--DAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCS 385
+ Q GTY C + +++ D+QL + ++A P E +S+ + A + C+
Sbjct: 944 QLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA--GPRE--PPTQVSVVQDGVATLECN 999
Query: 386 VHGLPTPALRWTKDSTPLG---------DGPMLSLSSITFDSNGTYVCEASLPTVPVLSR 436
G P P + W +D P+G G L + G Y C A + R
Sbjct: 1000 ATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE----NLAGR 1055
Query: 437 TQ-NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEP 495
+ F L V PEL +++P + + +TL+C A G P P + W + G P
Sbjct: 1056 AERKFELSVLVPPEL-IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR-GEEPVS- 1112
Query: 496 IPGRQGW-VSSSLTLKVTSALSRDG--ISCEASNPHGNKRHVFHFGTVSP 542
PG + ++ LK+T +D SC ASN G R F + P
Sbjct: 1113 -PGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP 1161
Score = 75.1 bits (183), Expect = 2e-13
Identities = 135/534 (25%), Positives = 196/534 (36%), Gaps = 84/534 (15%)
Query: 43 VMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPY 102
V+ G+ V LDC + G P + GS L M G +
Sbjct: 1947 VLEGQEVRLDC----------------EADGQPPPDVAWLKDGSPLGQDM----GPHLRF 1986
Query: 103 QLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVM 162
LD G LVL + D Y CV AG +NV P + + GTL V
Sbjct: 1987 YLDG-GSLVLKGLRASDAGAYTCVAH-NPAGEDARLHTVNVLVPPTIKQGADGSGTL-VS 2043
Query: 163 EDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTL 222
C R G+P ++W ++G L +P ++ RT+ SG S +
Sbjct: 2044 RPGELVTMVCPVR-GSPPIHVSWLKDG--LPLP--------LSQRTLLHGSGHTLRISKV 2092
Query: 223 YLRLRKDDRDAS-FHCAAHYSLPEGRHGRLDSPTFHLTLHYPT--EHVQFWVGSPSTPAG 279
L DA F C A + P G R F L + P E V+F
Sbjct: 2093 QLA------DAGIFTCVA--ASPAGVADR----NFTLQVQVPPVLEPVEFQNDVV----- 2135
Query: 280 WVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEG--NLTLEGVTRGQSGTYGC 337
V G V+L C G P P L + E +L+ +LE +L LE V G SGTY C
Sbjct: 2136 -VVRGSLVELPCEARGVPLP---LVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSC 2191
Query: 338 RVEDYDAADDVQLSKTLELR----VAYLDPLELSE-GKVLSLPLNSSAVVN--CSVHGLP 390
V +S+ E R + ++P + + G+ L L A + C G P
Sbjct: 2192 ----------VAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTP 2241
Query: 391 TPALRWTKDSTPLG--DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSP 448
P + W KD L + + + G Y C A P + ++F + VQ P
Sbjct: 2242 QPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAI---EKSFRVRVQAPP 2298
Query: 449 ELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLT 508
+ P+ G ++ L CS P PK++W + G E + L
Sbjct: 2299 NI-VGPRGPRFVVGLAPG-QLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQ 2356
Query: 509 LKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAVSVGLLL 562
L+ S SC A N G+ F + T ++G + V+V+ LL
Sbjct: 2357 LQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALL 2410
Score = 72.4 bits (176), Expect = 1e-12
Identities = 99/401 (24%), Positives = 155/401 (38%), Gaps = 64/401 (15%)
Query: 108 GRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMED--- 164
GRL L+ Q Y CV A +A AR + A V+P + V +
Sbjct: 1896 GRLQLSRLQPAQAGTYTCV-----AENTQAEARKDFVV---AVLVAPRIRSSGVAREHHV 1947
Query: 165 -SAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
QE+ +G P P + W ++G L + + Y+ G L L
Sbjct: 1948 LEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDG-------GSLVLKG--- 1997
Query: 224 LRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVRE 283
LR D A + C AH P G RL + + + P Q GS + + R
Sbjct: 1998 --LRASDAGA-YTCVAHN--PAGEDARLHT----VNVLVPPTIKQGADGSGTLVS---RP 2045
Query: 284 GDTVQLLCRGDGSPSPEYTLFR----LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGC-- 337
G+ V ++C GSP + + L Q +L+ + L + V +G + C
Sbjct: 2046 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGH-TLRISKVQLADAGIFTCVA 2104
Query: 338 ----RVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPA 393
V D + VQ+ LE V + + + + G ++ LP C G+P P
Sbjct: 2105 ASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELP--------CEARGVPLPL 2155
Query: 394 LRWTKDSTP-----LGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSP 448
+ W KD P L GP L L ++ +GTY C A ++F L V P
Sbjct: 2156 VSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVA---VSEAGEARRHFQLTVMEPP 2212
Query: 449 ELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
++ + + S G + L+C A+G P P ++W + G
Sbjct: 2213 HIE--DSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 2251
Score = 71.6 bits (174), Expect = 2e-12
Identities = 129/555 (23%), Positives = 205/555 (36%), Gaps = 78/555 (14%)
Query: 8 AQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDHYMLEWF 67
AQA R +A LA + + E+ + VPP E++ + + T H L
Sbjct: 1037 AQAAHTGRYSCVAENLAGRAERKFELSVLVPP--ELIGDLDPLTNIT-AALHSPLTL--- 1090
Query: 68 LTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVV 127
L + G P A +G E DT Y L L + + Q D Y C+
Sbjct: 1091 LCEAMGIPPP-AIRWFRGEEPVSPGEDT------YLLAGGWMLKMTQTQEQDSGLYSCLA 1143
Query: 128 RAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYR 187
+ AG A + V P + E + + V++ + CN G+P PK+TW++
Sbjct: 1144 -SNEAGEARRNFSVEVLVPP-SIENEDLEEVIKVLDGQTAHLM-CNV-TGHPQPKLTWFK 1199
Query: 188 NGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGR 247
+G+ L R + +S L L+ A+ A HYS
Sbjct: 1200 DGRPL----------------ARGDAHHISPDGVLLQVLQ-----ANLSSAGHYSCIAAN 1238
Query: 248 HGRLDSPTFHLT-LHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRL 306
+ F L+ L PT + + V + + L+C PSP T +
Sbjct: 1239 AVGEKTKHFQLSVLLAPT--ILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKD 1296
Query: 307 QDEQEEVLNVNL---EGNLTLEGVTRGQSGTYGCRVEDY--DAADDVQLSKTLELRVAYL 361
E N+ L L + + +G Y C V + +A + + + ++
Sbjct: 1297 GAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKD 1356
Query: 362 DPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTP---------LGDGPMLSLS 412
DPL K + +NS+ + C +P P +RW KD P LG+G +L +
Sbjct: 1357 DPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQ 1416
Query: 413 SITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTA-------EI---EPKADGS 462
+G Y+C A T Q+F +L+Q P + EI E +A G
Sbjct: 1417 PTQVSDSGRYLCVA---TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGG 1473
Query: 463 WREGDEVT------LICSARGHPDPKLSWSQLGG--SPAEPIPGRQGWVSSSLTLKVTSA 514
E E+ L C P P L+W + S + + QG L + + A
Sbjct: 1474 VTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQG--GRVLQIPLVRA 1531
Query: 515 LSRDGISCEASNPHG 529
+ SC+ASN G
Sbjct: 1532 ENAGRYSCKASNEVG 1546
Score = 70.1 bits (170), Expect = 5e-12
Identities = 98/371 (26%), Positives = 138/371 (37%), Gaps = 38/371 (10%)
Query: 176 NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASF 235
NG P P+I W ++ Q + VP+ G+ LL +L+ ++ +
Sbjct: 43 NGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLY 102
Query: 236 HCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDG 295
C A E + G FHL + P + G+ G G V+L C G
Sbjct: 103 SCRA-----ENQAGTAQRD-FHLLVLTPPSVLG--AGAAQEVLGLA--GADVELQCWTSG 152
Query: 296 SPSPEYTLFRLQDEQEEV-----LNVNLEGN-LTLEGVTRGQSGTYGCRVEDYDAADDVQ 349
P+P+ + D Q + L V +G L + G G G Y C + A Q
Sbjct: 153 VPTPQVEWTK--DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA--FSPAG--Q 206
Query: 350 LSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVN--CSVHGLPTPALRWTKDSTPLGD-- 405
++ +LRV + P + + + +V C G+PTP + W KD L
Sbjct: 207 QARDFQLRV-HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST 265
Query: 406 -------GPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPK 458
G L L G Y C+AS T+ L V P ++ A P
Sbjct: 266 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATR---LDVYVPPTIEGAGGRPY 322
Query: 459 ADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRD 518
+ G V L C ARGHP P LSW G AE R S L L+ S
Sbjct: 323 VVKAVA-GRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSG 381
Query: 519 GISCEASNPHG 529
SC AS+P G
Sbjct: 382 LYSCVASSPAG 392
Score = 67.0 bits (162), Expect = 5e-11
Identities = 126/520 (24%), Positives = 182/520 (35%), Gaps = 87/520 (16%)
Query: 38 PPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRG 97
P +V+ + G+ V L+C G H L W A + E GS L+
Sbjct: 321 PYVVKAVAGRPVALECVARG-HPSPTLSWHHEGLPVAESNESRLETDGSVLR-------- 371
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
L+S G EA G Y CV + AG A + V P+ V+ G
Sbjct: 372 ------LESPG-----EASSGL---YSCVA-SSPAGEAVLQYSVEVQVPPQLL-VAEGLG 415
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLE----VPVEMNPEGYMTSRTVREAS 213
++ + E+ C + +G+P P I W +NG+ E V V + S
Sbjct: 416 QVTTIVGQPLELP-CQA-SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHS 473
Query: 214 GLLSLTSTLYLRLRKDDRDASFH---CAAHYSLPEGRH--GRLDSPTFHLTLHYPTEHVQ 268
GL + +T + + S H +P G++ G +F P +
Sbjct: 474 GLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVH--R 531
Query: 269 FWVGSPSTPA--GWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEG 326
W P P GW G L G P + +L L +E
Sbjct: 532 GWGAHPKPPLVEGWCSPGS---LWGEPTGIP----------------VAYSLPPPLQIEK 572
Query: 327 VTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPL-NSSAVVNCS 385
V G Y C AA ++ E+ + L P + G V L N+S + C
Sbjct: 573 VDLRDEGIYTC------AATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 626
Query: 386 VHGLPTPALRWTKDSTPLG---------DGPMLSLSSITFDSNGTYVCEASLPTVPVLSR 436
G+P P + W K P+ DG +L + G+Y C AS V
Sbjct: 627 ASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVAS----NVAGS 682
Query: 437 TQ-NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEP 495
T+ + L V P + + P G V L C+A G P P L W + G+P P
Sbjct: 683 TELRYGLRVNVPPRI---TLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK-DGNPVSP 738
Query: 496 --IPGRQGWVSSS-LTLKVTSALSRDGISCEASNPHGNKR 532
PG Q + LTL A SC A + G R
Sbjct: 739 AGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDR 778
Score = 65.9 bits (159), Expect = 1e-10
Identities = 109/474 (22%), Positives = 163/474 (34%), Gaps = 67/474 (14%)
Query: 103 QLDSQGRLV-LAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSV 161
Q+ +GRL+ + QV D Y+CV AG + + + P +V +
Sbjct: 1405 QVLGEGRLLQIQPTQVSDSGRYLCVA-TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEI 1463
Query: 162 M--EDSAQ-------EIATCN------SRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTS 206
+ E+ A+ EI N N P P +TWYR Q L E++
Sbjct: 1464 LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVS------- 1516
Query: 207 RTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEH 266
+L L + L + + + C A + E H L T
Sbjct: 1517 --------VLQGGRVLQIPLVRAENAGRYSCKASNEVGED--------WLHYELLVLTPP 1560
Query: 267 VQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFR--LQDEQEEVLNVNLEGN-LT 323
V V TV L C G+P P + + L L V +G L
Sbjct: 1561 VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQ 1620
Query: 324 LEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVN 383
+ + +Y C E+ + + K LRV + + + ++ LNSS +
Sbjct: 1621 VSTAEVADAASYMCVAENQAGSAE----KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLP 1676
Query: 384 CSVHGLPTPALRWTKDSTPLGDGP---------MLSLSSITFDSNGTYVCEASLPTVPVL 434
C VH P P + W KDS L G L L +G Y CEA +
Sbjct: 1677 CDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEA----LNAA 1732
Query: 435 SRTQNFT-LLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSP- 492
R Q L V P + A P+ R GD+ L C P+P ++W + G P
Sbjct: 1733 GRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK-DGQPL 1791
Query: 493 --AEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQT 544
A+ +G L ++ + SC+ SN G F P T
Sbjct: 1792 VLAQRTQALRG--GQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPT 1843
Score = 65.9 bits (159), Expect = 1e-10
Identities = 128/546 (23%), Positives = 189/546 (34%), Gaps = 86/546 (15%)
Query: 7 PAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDHYMLEW 66
P A+ A L LA A ++R+ PP + + TP
Sbjct: 2450 PVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPA---------L 2500
Query: 67 FLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCV 126
+ SG+ L G +L D R + Y+L L+L D + CV
Sbjct: 2501 LPCEASGSPKPLVVWWKDGQKL-----DFRLQQGAYRLLPSNALLLTAPGPQDSAQFECV 2555
Query: 127 VRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWY 186
V + G A ++ V P + T+++M A + TC+S G PAP ++W
Sbjct: 2556 V-SNEVGEAHRLYQVTVHVPPTIAD-DQTDFTVTMM---APVVLTCHS-TGIPAPTVSWS 2609
Query: 187 RNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEG 246
+ G +L GY S SG L + L + + + C+A S
Sbjct: 2610 KAGAQLGA----RGSGYRVS-----PSGALEIGQALPIHAGR------YTCSARNS---- 2650
Query: 247 RHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRL 306
+ H + + PS E V L C G P P T
Sbjct: 2651 ------AGVAHKHVFLTVQASPVVKPLPSVVRAVAEE--EVLLPCEASGIPRPTITW--- 2699
Query: 307 QDEQEEVLNVNLE--------GNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRV 358
Q+E LNV G L + + +G Y C ++ + + KT R+
Sbjct: 2700 ---QKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS---AMGKT---RL 2750
Query: 359 AYLDPLELSEGKV-LSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGP---------M 408
P + G LS S A + C G P P + W KD P+
Sbjct: 2751 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE 2810
Query: 409 LSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDE 468
L + ++ GTY C A V R + T+LV P T D S R GD
Sbjct: 2811 LLVKNLEGQDAGTYTCTAE-NAVGRARRRVHLTILVL--PVFTTLP----GDRSLRLGDR 2863
Query: 469 VTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPH 528
+ L C+ARG P P++ W+ E + + G S+L S C A N
Sbjct: 2864 LWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG--GSTLQRAAVSREDSGTYVCWAENRV 2921
Query: 529 GNKRHV 534
G + V
Sbjct: 2922 GRTQAV 2927
Score = 65.5 bits (158), Expect = 1e-10
Identities = 113/458 (24%), Positives = 172/458 (37%), Gaps = 52/458 (11%)
Query: 116 QVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSR 175
+V D Y C+ + AG E + R+ V A P V P V Q + C S
Sbjct: 2268 RVRDAGLYTCLAES-PAGAIEKSFRVRVQAPPNI--VGPRGPRFVVGLAPGQLVLEC-SV 2323
Query: 176 NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASF 235
PAPKITW+R+G L+ E T R L ST D D S
Sbjct: 2324 EAEPAPKITWHRDGIVLQ-------EDAHTQFPERGRFLQLQALSTA------DSGDYS- 2369
Query: 236 HCAAHYSLPEGRHGRLDSPTFHLTLH-YPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGD 294
C A + S F + +H PT PA V T L C+ D
Sbjct: 2370 -CTARNAAGS------TSVAFRVEIHTVPTIR-------SGPPAVNVSVNQTALLPCQAD 2415
Query: 295 GSPSPEYTLFRLQ---DEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLS 351
G P+P + + + D + + EG+L ++ V +G Y C + +D
Sbjct: 2416 GVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD----R 2471
Query: 352 KTLELRVAYLDPLELSEG-KVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPL------G 404
+ +LRV L+P ++ L+L ++ A++ C G P P + W KD L G
Sbjct: 2472 QGRDLRV--LEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQG 2529
Query: 405 DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWR 464
+L +++ + G +++ V + L Q + + + + D +
Sbjct: 2530 AYRLLPSNALLLTAPGPQ--DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVT 2587
Query: 465 EGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEA 524
V L C + G P P +SWS+ G G + S +L + + +C A
Sbjct: 2588 MMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSA 2647
Query: 525 SNPHG-NKRHVFHFGTVSPQTSQAGVAVMAVAVSVGLL 561
N G +HVF SP V AVA LL
Sbjct: 2648 RNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 2685
Score = 62.8 bits (151), Expect = 9e-10
Identities = 115/485 (23%), Positives = 176/485 (36%), Gaps = 108/485 (22%)
Query: 28 DAQAEVRLSVPPLVE---------VMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRL 78
D +++ VPP++E V+RG V L C G ++ W P L
Sbjct: 2112 DRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGV-PLPLVSWM----KDGEPLL 2166
Query: 79 ASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEAT 138
+ + QG P QL++ G GD Y CV AG A
Sbjct: 2167 SQSLEQG--------------PSLQLEAVG--------AGDSGTYSCVA-VSEAGEARRH 2203
Query: 139 ARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEM 198
+L V P E S LS+ + E+ C+++ G P P ITW+++GQ L +E
Sbjct: 2204 FQLTVMEPPHI-EDSGQPTELSLTPGAPMELL-CDAQ-GTPQPNITWHKDGQAL-TRLEN 2259
Query: 199 NPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHL 258
N +T LR+R DA + L E G ++ +F +
Sbjct: 2260 NSR------------------ATRVLRVR----DAGLYTC----LAESPAGAIEK-SFRV 2292
Query: 259 TLHYPTEHV-----QFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEV 313
+ P V +F VG + G V L C + P+P+ T R +E
Sbjct: 2293 RVQAPPNIVGPRGPRFVVG--------LAPGQLV-LECSVEAEPAPKITWHRDGIVLQED 2343
Query: 314 LNVNLEGN---LTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGK 370
+ L L+ ++ SG Y C + AA ++ +E+ P S
Sbjct: 2344 AHTQFPERGRFLQLQALSTADSGDYSCTARN--AAGSTSVAFRVEIHTV---PTIRSGPP 2398
Query: 371 VLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGP---------MLSLSSITFDSNGT 421
+++ +N +A++ C G+P P + W KD PL L + + G
Sbjct: 2399 AVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 2458
Query: 422 YVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLI-CSARGHPD 480
Y+C AS S Q L V L+ I P L+ C A G P
Sbjct: 2459 YLCLASNSAG---SDRQGRDLRV-----LEPPAIAPSPSNLTLTAHTPALLPCEASGSPK 2510
Query: 481 PKLSW 485
P + W
Sbjct: 2511 PLVVW 2515
Score = 50.4 bits (119), Expect = 4e-06
Identities = 83/368 (22%), Positives = 135/368 (36%), Gaps = 62/368 (16%)
Query: 97 GRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNK 156
G + + G L++ + D Y C A G A L + P T + P
Sbjct: 2798 GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE-NAVGRARRRVHLTILVLPVFTTL-PGD 2855
Query: 157 GTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTV--REASG 214
+L + + + C +R G+P P+I W N + + V G R RE SG
Sbjct: 2856 RSLRLGD---RLWLRCAAR-GSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSG 2911
Query: 215 LLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSP 274
++ C A E R GR + +F HV+
Sbjct: 2912 -------------------TYVCWA-----ENRVGRTQAVSF--------VHVKEAPVLQ 2939
Query: 275 STPAGWVRE--GDTVQLLC--RGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRG 330
++ E G ++QL C RGD P + L + + G+LT+ R
Sbjct: 2940 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERD 2999
Query: 331 QSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLP 390
+G Y C E+ ++ ++K + + V P+ E + +++ + C G P
Sbjct: 3000 DAGRYQCLAEN-----EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP 3054
Query: 391 TPALRWTKDSTP---------LGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFT 441
TP + W + P L DG L L ++ GTY C A + S T
Sbjct: 3055 TPTIEWLQAGQPLRASRRLRTLPDG-SLWLENVETGDAGTYDCVAH---NLLGSATARAF 3110
Query: 442 LLVQGSPE 449
L+V+G P+
Sbjct: 3111 LVVRGEPQ 3118
Score = 38.5 bits (88), Expect = 0.017
Identities = 45/192 (23%), Positives = 67/192 (34%), Gaps = 32/192 (16%)
Query: 379 SAVVNCSVHGLPTPALRWTKDS----TPLG--------------------DGPMLSLSSI 414
S + C +G P P + W KD+ PLG +G L I
Sbjct: 35 SLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRI 94
Query: 415 TFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICS 474
+G Y C A + ++F LLV P + A + G G +V L C
Sbjct: 95 QEGDSGLYSCRAENQAG---TAQRDFHLLVLTPPSVLGAGAAQEVLG--LAGADVELQCW 149
Query: 475 ARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRD--GISCEASNPHGNKR 532
G P P++ W++ P P L++T + D C A +P G +
Sbjct: 150 TSGVPTPQVEWTK-DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQA 208
Query: 533 HVFHFGTVSPQT 544
F +P T
Sbjct: 209 RDFQLRVHAPPT 220
Score = 31.2 bits (69), Expect = 2.8
Identities = 34/118 (28%), Positives = 44/118 (37%), Gaps = 23/118 (19%)
Query: 448 PELKTAEIEP--------KADGSWREGDEVTLICSARGHPDPKLSW---SQLGGSPA--E 494
P L T + P KA+ S G +TL C A G P P++ W +QL G P
Sbjct: 7 PLLNTGSVVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWA 66
Query: 495 PIPGRQGW--VSSSLTLKVTSALSRDGI--------SCEASNPHGNKRHVFHFGTVSP 542
GW V L +L I SC A N G + FH ++P
Sbjct: 67 GYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTP 124
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 86.7 bits (213), Expect = 6e-17
Identities = 121/458 (26%), Positives = 183/458 (39%), Gaps = 68/458 (14%)
Query: 106 SQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDS 165
S G+L + AQ D Y C G A A +L V P+ TE+ P T+ + +
Sbjct: 629 SSGKLRIPAAQERDAGTYTCRA-VNELGDASAEIQLAVGHAPQLTEL-PRDVTVELGRSA 686
Query: 166 AQEIATCNSRNGNPAPKITWYR-NGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYL 224
+ C + G P P +TW R +GQ P+ + SR+ + SG+L S
Sbjct: 687 ---LLACRA-TGRPPPTVTWRRGDGQ----PLGLRLGAGRGSRSRQPDSGVLFFESVA-- 736
Query: 225 RLRKDDRDASFHCAAHYSLPEGRHGRLDSPT-FHLTLHYPTEHVQFWVGSPSTPAGWVRE 283
+ A + C A G++ + +T H P + S P V E
Sbjct: 737 ----PEDQAPYVCEARNVF-----GKVQAEARLIVTGHAPPQIAS------SAPTVRVLE 781
Query: 284 GDTVQLLCRG-DGSPSPEYTLFRLQDEQE----EVLNVNLEGNLTLEGVTRGQSGTYGCR 338
G V L C G P PE L+D + ++ +G+L L+ + +G Y C
Sbjct: 782 GQPVSLPCIVLAGRPLPERHW--LKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCV 839
Query: 339 VEDYDAAD--DVQLSKTLELRVAYLDPLELS-EGKVLSLPLNSSAVVNCSVHGLPTPALR 395
+ + DV+L + R+ ++ EG SLP C G+P P +
Sbjct: 840 ATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLP--------CVASGVPAPTIT 891
Query: 396 WTKDSTPLGD-GP--------MLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQG 446
WTK++ L GP L ++ + G YVC A T V +Q L V
Sbjct: 892 WTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTA---TNTVGFSSQEMRLSVNT 948
Query: 447 SPEL-----KTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQG 501
P + + A + + + G+EVTL C A+G P P ++W++ P PI R G
Sbjct: 949 KPRIHMNGSRNANVPLQVTA--KAGEEVTLDCEAKGSPPPLVTWTK-DSRPVPPITNRYG 1005
Query: 502 WV-SSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFG 538
+ S SL L C ASNP G+ H + G
Sbjct: 1006 LLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLG 1043
Score = 66.2 bits (160), Expect = 8e-11
Identities = 94/432 (21%), Positives = 158/432 (36%), Gaps = 61/432 (14%)
Query: 75 RPRLASAEMQGS---ELQVTMHDTR-GRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAG 130
+P L S + + LQ+ + R G +Q + A +E Y C
Sbjct: 325 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTA-VS 383
Query: 131 AAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAP-KITWYRNG 189
AGT A A++ V P +PN + S E A + R AP +TW R+
Sbjct: 384 RAGTGRAKAQIVVTDPPPQLVPAPN------VTVSPGETAVLSCRVLGEAPYNLTWVRDW 437
Query: 190 QRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHG 249
+ L P + ++ E SG++ Y C A +G
Sbjct: 438 RVL--PASTGRVAQLADLSL-EISGIIPTDGGRY------------QCVA-----SNANG 477
Query: 250 RLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQD- 308
+ + L P + T + +G V++ C G P+P + R
Sbjct: 478 VTRASVWLLVREAPQVSIH-------TSSQHFSQGVEVKVSCSASGYPTPHISWSRESQA 530
Query: 309 -EQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELS 367
+++ ++V+ +G L ++GV +G Y C+ + D ++ + Y DP +S
Sbjct: 531 LQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVT------LYYTDPPSVS 584
Query: 368 E-GKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGP------MLSLSSITFDSNG 420
V+ + + AV+ C G+P P + W + + P L + + G
Sbjct: 585 AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAG 644
Query: 421 TYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPD 480
TY C A + Q L V +P+L E D + G L C A G P
Sbjct: 645 TYTCRAVNELGDASAEIQ---LAVGHAPQL----TELPRDVTVELGRSALLACRATGRPP 697
Query: 481 PKLSWSQLGGSP 492
P ++W + G P
Sbjct: 698 PTVTWRRGDGQP 709
Score = 65.5 bits (158), Expect = 1e-10
Identities = 111/434 (25%), Positives = 163/434 (37%), Gaps = 79/434 (18%)
Query: 123 YVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPK 182
Y CV + A G A+ L V EA +VS + T S E+ S +G P P
Sbjct: 468 YQCVA-SNANGVTRASVWLLV---REAPQVSIH--TSSQHFSQGVEVKVSCSASGYPTPH 521
Query: 183 ITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYS 242
I+W R Q L+ SR +A G L + + +D A +YS
Sbjct: 522 ISWSRESQALQED----------SRIHVDAQGTLIIQG-----VAPED-------AGNYS 559
Query: 243 LPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAG----WVREGDTVQLLCRGDGSPS 298
D T +TL+Y PS A V G+ L+C G P
Sbjct: 560 CQATNEVGTDQET--VTLYY--------TDPPSVSAVNAVVLVAVGEEAVLVCEASGVPP 609
Query: 299 PEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRV--EDYDAADDVQLSKTLEL 356
P +R E + G L + +GTY CR E DA+ ++QL+
Sbjct: 610 PRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP 669
Query: 357 RVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK-DSTPLG----------- 404
++ L + +++ L SA++ C G P P + W + D PLG
Sbjct: 670 QLTELP-------RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRS 722
Query: 405 ---DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQ-NFTLLVQGSPELKTAEIEPKAD 460
D +L S+ + YVCEA V + Q L+V G + A P
Sbjct: 723 RQPDSGVLFFESVAPEDQAPYVCEAR----NVFGKVQAEARLIVTGHAPPQIASSAPTV- 777
Query: 461 GSWREGDEVTLICSA-RGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDG 519
EG V+L C G P P+ W + G P PG + + + +L + AL
Sbjct: 778 -RVLEGQPVSLPCIVLAGRPLPERHWLK-DGRPLP--PGSRHSIRADGSLHLDRALQEHA 833
Query: 520 --ISCEASNPHGNK 531
SC A+N G++
Sbjct: 834 GRYSCVATNTAGSQ 847
Score = 50.4 bits (119), Expect = 4e-06
Identities = 60/250 (24%), Positives = 102/250 (40%), Gaps = 26/250 (10%)
Query: 328 TRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVH 387
++ + GTY C A + V P +L +++ +AV++C V
Sbjct: 370 SKAEEGTYECT-----AVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 424
Query: 388 GLPTPALRWTKD--STPLGDGPMLSLSSITFD-------SNGTYVCEASLPTVPVLSRTQ 438
G L W +D P G + L+ ++ + G Y C AS ++R
Sbjct: 425 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVAS--NANGVTRAS 482
Query: 439 NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPG 498
+ LLV+ +P++ + + +G EV + CSA G+P P +SWS+ + E
Sbjct: 483 VW-LLVREAPQVSIHT----SSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQE---D 534
Query: 499 RQGWVSSSLTLKVTSALSRD--GISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAV 556
+ V + TL + D SC+A+N G + P + A AV+ VAV
Sbjct: 535 SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV 594
Query: 557 SVGLLLLVVA 566
+L+ A
Sbjct: 595 GEEAVLVCEA 604
Score = 44.3 bits (103), Expect = 3e-04
Identities = 31/117 (26%), Positives = 49/117 (41%), Gaps = 5/117 (4%)
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
R P Y + +G L++A+ D YVC G + RL+V KP
Sbjct: 902 RGPHYNVSKEGTLLIAQPSAQDAGAYVCTA-TNTVGFSSQEMRLSVNTKPRIHMNGSRNA 960
Query: 158 T--LSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREA 212
L V + +E+ G+P P +TW ++ + VP N G + S ++R A
Sbjct: 961 NVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSR--PVPPITNRYGLLPSGSLRLA 1015
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 84.3 bits (207), Expect = 3e-16
Identities = 81/299 (27%), Positives = 135/299 (45%), Gaps = 36/299 (12%)
Query: 281 VREGDTVQLLCRGDGSPSPEYTLFRLQDE----QEEVLNVNLEGNLTLEGVTRGQSGTYG 336
V G+TV CR +G+P PE R +E + LN+ +G L ++ G Y
Sbjct: 257 VTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQ 316
Query: 337 CRVEDYDAADDVQLSKTLELRVAYLD----PLELSEGKVLSLPLNSSAVVNCSVHGLPTP 392
C + + A +V KT E+ + Y P + + + + + S + CS G P P
Sbjct: 317 CMAK--NVAGEV---KTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPP 371
Query: 393 ALRWTK-DSTPLGDGPMLSLS--------SITFDSNGTYVCEASLPTVPVLSRTQNFTLL 443
+ WT+ D TPL P ++++ ++ +G Y C A T + S ++
Sbjct: 372 RISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSA---TNNIDSVHATAFII 428
Query: 444 VQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWV 503
VQ P+ + P+ D EG V C A+G+P P ++W++ GGS R+ V
Sbjct: 429 VQALPQF---TVTPQ-DRVVIEGQTVDFQCEAKGNPPPVIAWTK-GGSQLS--VDRRHLV 481
Query: 504 SSSLTLKVTSALSRD--GISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMA-VAVSVG 559
SS TL+++ D C+A N G+++ V H TV P+ + ++ + V VG
Sbjct: 482 LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHL-TVQPRVTPVFASIPSDTTVEVG 539
Score = 71.2 bits (173), Expect = 2e-12
Identities = 78/341 (22%), Positives = 128/341 (37%), Gaps = 66/341 (19%)
Query: 171 TCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDD 230
TC + GNP P+I W RN L + + SR G L + +T ++
Sbjct: 266 TCRAE-GNPKPEIIWLRNNNELSMKTD--------SRLNLLDDGTLMIQNT------QET 310
Query: 231 RDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVRE------- 283
+ C A E + T +TL Y GSP+ P ++
Sbjct: 311 DQGIYQCMAKNVAGEVK-------TQEVTLRY--------FGSPARPTFVIQPQNTEVLV 355
Query: 284 GDTVQLLCRGDGSPSPEYTLFRLQDEQEEV---LNVNLEGNLTLEGVTRGQSGTYGC--- 337
G++V L C G P P + R V +N+ G L ++ V +G SG Y C
Sbjct: 356 GESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSAT 415
Query: 338 -RVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRW 396
++ A + + + V D + + EG+ + C G P P + W
Sbjct: 416 NNIDSVHATAFIIVQALPQFTVTPQDRVVI-EGQTVDF--------QCEAKGNPPPVIAW 466
Query: 397 TKDSTPLG--------DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSP 448
TK + L L +S + G Y C+A V ++ +Q + P
Sbjct: 467 TKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQA----VNIIG-SQKVVAHLTVQP 521
Query: 449 ELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
+ +D + G V L CS++G P+P ++W++ G
Sbjct: 522 RVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDG 562
Score = 60.1 bits (144), Expect = 6e-09
Identities = 69/309 (22%), Positives = 115/309 (37%), Gaps = 38/309 (12%)
Query: 108 GRLVLAEAQVGDERDYVCVVR--AGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDS 165
G L++ Q D+ Y C+ + AG T E T R + P + V E
Sbjct: 300 GTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESV 359
Query: 166 AQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLR 225
E S G+P P+I+W R G R +PV+ ++ + LY++
Sbjct: 360 TLEC----SATGHPPPRISWTR-GDRTPLPVDPRVN--------------ITPSGGLYIQ 400
Query: 226 LRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGD 285
+ C+A ++ + H T + + + +P V EG
Sbjct: 401 NVVQGDSGEYACSATNNID----------SVHATAFIIVQALPQFTVTPQDRV--VIEGQ 448
Query: 286 TVQLLCRGDGSPSP--EYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYD 343
TV C G+P P +T Q + V G L + GV G Y C+ +
Sbjct: 449 TVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNII 508
Query: 344 AADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPL 403
+ V T++ RV P+ S ++ + ++ + CS G P PA+ W KD +
Sbjct: 509 GSQKVVAHLTVQPRVT---PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQV 565
Query: 404 GDGPMLSLS 412
+ +S
Sbjct: 566 TESGKFHIS 574
Score = 56.2 bits (134), Expect = 8e-08
Identities = 48/176 (27%), Positives = 76/176 (43%), Gaps = 17/176 (9%)
Query: 363 PLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLG----------DGPMLSLS 412
P SE + + ++ C G P P + W +++ L D L +
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
Query: 413 SITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLI 472
+ G Y C A V +TQ TL GSP T I+P+ + G+ VTL
Sbjct: 306 NTQETDQGIYQCMAKNVAGEV--KTQEVTLRYFGSPARPTFVIQPQ-NTEVLVGESVTLE 362
Query: 473 CSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDG--ISCEASN 526
CSA GHP P++SW++ +P P+ R ++ S L + + + D +C A+N
Sbjct: 363 CSATGHPPPRISWTRGDRTPL-PVDPRVN-ITPSGGLYIQNVVQGDSGEYACSATN 416
Score = 53.9 bits (128), Expect = 4e-07
Identities = 75/302 (24%), Positives = 110/302 (36%), Gaps = 57/302 (18%)
Query: 38 PPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRG 97
P EV+ G+SV L+C+ TG H + W DR + L V
Sbjct: 348 PQNTEVLVGESVTLECSATG-HPPPRISWTRGDR--------------TPLPV------- 385
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
P + G L + GD +Y C + ATA + V A P+ T V+P
Sbjct: 386 -DPRVNITPSGGLYIQNVVQGDSGEYACSA-TNNIDSVHATAFIIVQALPQFT-VTPQDR 442
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
V+E + C ++ GNP P I W + G +L V R + +SG L
Sbjct: 443 V--VIEGQTVDF-QCEAK-GNPPPVIAWTKGGSQLSV----------DRRHLVLSSGTLR 488
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
++ + H Y HLT+ V + S +T
Sbjct: 489 ISG------------VALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT- 535
Query: 278 AGWVREGDTVQLLCRGDGSPSPEYTLFR--LQDEQEEVLNVNLEGNLTLEGVTRGQSGTY 335
V G VQL C G P P T + +Q + +++ EG LT+ V +G Y
Sbjct: 536 ---VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRY 592
Query: 336 GC 337
C
Sbjct: 593 EC 594
>gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens]
Length = 600
Score = 81.3 bits (199), Expect = 2e-15
Identities = 119/508 (23%), Positives = 196/508 (38%), Gaps = 70/508 (13%)
Query: 104 LDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVME 163
L + L + A++ D+ Y C +A A ARL V P+ + G + +
Sbjct: 106 LSGEHHLKILRAELQDDAVYEC--QAIQAAIRSRPARLTVLVPPDDPVILG--GPVISLR 161
Query: 164 DSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
TC++ N PA I W R G+ + G S+T+ S+ STL+
Sbjct: 162 AGDPLNLTCHADNAKPAASIIWLRKGEVI--------NGATYSKTLLRDGKRESIVSTLF 213
Query: 224 LRLRKDDRDASFHC-AAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVR 282
+ + S C A + ++P G+ S T + H P ++ S V
Sbjct: 214 ISPGDVENGQSIVCRATNKAIPGGKE---TSVTIDIQ-HPPLVNL-------SVEPQPVL 262
Query: 283 EGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDY 342
E + V C +P+ T +R + + + E T T S C V
Sbjct: 263 EDNVVTFHCSAKANPA--VTQYRWAKRGQIIKEASGEVYRTTVDYTY-FSEPVSCEVT-- 317
Query: 343 DAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK--DS 400
+A LS+T+++ Y P +E + L + L S A+ +C+ G P+ + W K
Sbjct: 318 NALGSTNLSRTVDV---YFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSG 374
Query: 401 TPLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKAD 460
L + L+L S+ + G YVC A +P V R TL V G P + + + +
Sbjct: 375 VVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGER--EVTLTVNGPPIISSTQTQHAL- 431
Query: 461 GSWREGDEVTLICSARGHPDP-KLSWS---------QLGGSPAEPIPGRQGWVSSSLTLK 510
G++ + C R P P +++WS G E I +G +S+
Sbjct: 432 ----HGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISN 487
Query: 511 VTSALSRDGISCEASNPHGNKRHVFHFGTV-SPQTSQAGV--------AVMAVAVSVG-- 559
+ A + +C A N G+ + S S AG+ ++ VAV G
Sbjct: 488 IVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVA 547
Query: 560 -LLLLVVAVFYCVRRKGGPCCRQRREKG 586
L+L+ V +C C R +R G
Sbjct: 548 FLVLMATIVAFC-------CARSQRSTG 568
>gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens]
Length = 778
Score = 80.1 bits (196), Expect = 5e-15
Identities = 116/495 (23%), Positives = 191/495 (38%), Gaps = 64/495 (12%)
Query: 104 LDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVME 163
L + L + A++ D+ Y C +A A ARL V P+ + G + +
Sbjct: 106 LSGEHHLKILRAELQDDAVYEC--QAIQAAIRSRPARLTVLVPPDDPVILG--GPVISLR 161
Query: 164 DSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
TC++ N PA I W R G+ + G S+T+ S+ STL+
Sbjct: 162 AGDPLNLTCHADNAKPAASIIWLRKGEVI--------NGATYSKTLLRDGKRESIVSTLF 213
Query: 224 LRLRKDDRDASFHC-AAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVR 282
+ + S C A + ++P G+ S T + H P ++ S V
Sbjct: 214 ISPGDVENGQSIVCRATNKAIPGGKE---TSVTIDIQ-HPPLVNL-------SVEPQPVL 262
Query: 283 EGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDY 342
E + V C +P+ T +R + + + E T T S C V
Sbjct: 263 EDNVVTFHCSAKANPA--VTQYRWAKRGQIIKEASGEVYRTTVDYTY-FSEPVSCEVT-- 317
Query: 343 DAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK--DS 400
+A LS+T+++ Y P +E + L + L S A+ +C+ G P+ + W K
Sbjct: 318 NALGSTNLSRTVDV---YFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSG 374
Query: 401 TPLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKAD 460
L + L+L S+ + G YVC A +P V R TL V G P + + + +
Sbjct: 375 VVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGER--EVTLTVNGPPIISSTQTQHAL- 431
Query: 461 GSWREGDEVTLICSARGHPDP-KLSWS---------QLGGSPAEPIPGRQGWVSSSLTLK 510
G++ + C R P P +++WS G E I +G +S+
Sbjct: 432 ----HGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISN 487
Query: 511 VTSALSRDGISCEASNPHGNKRHVFHFGTV-SPQTSQAGV--------AVMAVAVSVGLL 561
+ A + +C A N G+ + S S AG+ ++ VAV G+
Sbjct: 488 IVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVA 547
Query: 562 LLV----VAVFYCVR 572
LV + F C R
Sbjct: 548 FLVLMATIVAFCCAR 562
>gi|166295173 kin of IRRE like [Homo sapiens]
Length = 757
Score = 80.1 bits (196), Expect = 5e-15
Identities = 108/497 (21%), Positives = 190/497 (38%), Gaps = 79/497 (15%)
Query: 107 QGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSA 166
Q L + +A++ D+ Y C +A A A+L V PE T + + G + +++
Sbjct: 82 QYNLEITDAELSDDASYEC--QATEAALRSRRAKLTVLIPPEDTRI--DGGPVILLQAGT 137
Query: 167 QEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRL 226
TC + N PA I W+R+G + EG + S + + + S L +
Sbjct: 138 PHNLTCRAFNAKPAATIIWFRDGTQ--------QEGAVASTELLKDGKRETTVSQLLINP 189
Query: 227 RKDDRDASFHC-AAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGD 285
D F C + + ++P G+ ++ L +H+P + S V+EG+
Sbjct: 190 TDLDIGRVFTCRSMNEAIPSGKETSIE-----LDVHHPP------TVTLSIEPQTVQEGE 238
Query: 286 TVQLLCRGDGSPSPEYTLFR-------LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCR 338
V C+ + +PE +R ++D E N++ + E V+ C
Sbjct: 239 RVVFTCQ--ATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVS--------CE 288
Query: 339 VEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK 398
V + + +V L + P + + K + + S + C G P L WTK
Sbjct: 289 VHNKVGSTNVS-----TLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK 343
Query: 399 --DSTPLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIE 456
+ L + L L S+T GTY C A +P + V R L V G P + + ++
Sbjct: 344 KDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAER--EVPLYVNGPPIISSEAVQ 401
Query: 457 PKADGSWREGDEVTLICSARGHPDPKLSWS---------QLGGSPAEPIPGRQGWVSSSL 507
G +G +V + PD +++W+ L E G +S+
Sbjct: 402 YAVRG---DGGKVECFIGSTPPPD-RIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLT 457
Query: 508 TLKVTSALSRDGISCEASNPHG--------NKRHVFHFGTVSPQTSQAGVAVMAVAVSVG 559
V A + +C A N G +R V G ++ T A + +
Sbjct: 458 INNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILL-------- 509
Query: 560 LLLLVVAVFYCVRRKGG 576
+ + VF+ RR+ G
Sbjct: 510 IFFFIALVFFLYRRRKG 526
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 79.3 bits (194), Expect = 9e-15
Identities = 115/518 (22%), Positives = 188/518 (36%), Gaps = 96/518 (18%)
Query: 9 QARGAPRLLLLAVLLAAHPDAQAEVR---LSVPPLVE-----VMRGKSVILDCTPTGTHD 60
Q G+ L +VL+ P + + L+ P +E V G+++ L+C G
Sbjct: 2894 QVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPG-QA 2952
Query: 61 HYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDE 120
H + W+ R G+ P H T G SQ RL L D
Sbjct: 2953 HAQVTWY--KRGGSLP--------------ARHQTHG--------SQLRLHLVSP--ADS 2986
Query: 121 RDYVCVVRAGAAGTAEATARLNV--------FAKPEATEVSPNKGTLSVMEDSAQEIATC 172
+YVC +G EA+ + V + + P T+ +D++ + C
Sbjct: 2987 GEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFK---C 3043
Query: 173 NSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRD 232
+G + W Q LE V ++P G ++++ T +
Sbjct: 3044 LIHDGAAPISLEWKTRNQELEDNVHISPNG-----------SIITIVGT------RPSNH 3086
Query: 233 ASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCR 292
++ C A +G S +L++H P P P WV+ G V L C
Sbjct: 3087 GTYRCVA-----SNAYGVAQS-VVNLSVHGPPTVSVL----PEGPV-WVKVGKAVTLECV 3135
Query: 293 GDGSPSPEYTLFRLQD-----EQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADD 347
G P R+ EQ ++ L + +GTY C ++
Sbjct: 3136 SAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQ 3195
Query: 348 VQLSKTLEL-RVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLG-- 404
Q+ ++ +A P +E L++ +A + CS G P P + W+K +PL
Sbjct: 3196 KQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQ 3255
Query: 405 ---DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADG 461
+G L + + +G Y+C A+ P + +L SP T E
Sbjct: 3256 HRLEGDTLIIPRVAQQDSGQYICNATSPA----GHAEATIILHVESPPYATTVPE---HA 3308
Query: 462 SWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGR 499
S + G+ V L C A G P WS++G S +PGR
Sbjct: 3309 SVQAGETVQLQCLAHGTPPLTFQWSRVGSS----LPGR 3342
Score = 63.9 bits (154), Expect = 4e-10
Identities = 77/293 (26%), Positives = 115/293 (39%), Gaps = 45/293 (15%)
Query: 281 VREGDTVQLLCRGDGSPSPEYTLF--RLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCR 338
VR G V +C S SP YTL RL + + ++ G LT+ V +GTY C
Sbjct: 1783 VRPGADVTFICTAK-SKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCT 1841
Query: 339 VEDYDAADD------VQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTP 392
+ A D VQ S TL V + P +L+ + A CS G PTP
Sbjct: 1842 GSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLT------VQPGQLAEFRCSATGSPTP 1895
Query: 393 ALRWTKDSTPLGD--------GPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLV 444
L WT P G G +L L ++ Y+C A ++R L V
Sbjct: 1896 TLEWT--GGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARA---VLHV 1950
Query: 445 QGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVS 504
G + ++ P+ G V L C A G P ++W + GGS + ++
Sbjct: 1951 HGGGGPRV-QVSPERT-QVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIA 2008
Query: 505 SSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAVS 557
+ L +T+A C A++P G T+QA + V+ ++ S
Sbjct: 2009 TLLIPAITTA-DAGFYLCVATSPAG--------------TAQARIQVVVLSAS 2046
Score = 63.2 bits (152), Expect = 7e-10
Identities = 102/498 (20%), Positives = 176/498 (35%), Gaps = 55/498 (11%)
Query: 89 QVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPE 148
QVT H G P + RL L D +YVC V G++G EA+ + + A
Sbjct: 2757 QVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVM-GSSGPLEASVLVTIEASGS 2815
Query: 149 ATEVSPNKGTLSVM--EDSAQEIATCNSRN------GNPAPKITWYRNGQRLEVPVEMNP 200
+ P G + E S+ +A + + G ++TW++ G L +++
Sbjct: 2816 SAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHG 2875
Query: 201 EGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTL 260
++ SG S T + + ++ G + +P +
Sbjct: 2876 PLLRLNQVSPADSGEYSCQVT--------GSSGTLEASVLVTIEPSSPGPIPAPGLAQPI 2927
Query: 261 HYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEG 320
+ + V EG T+ L C G + T ++ + +
Sbjct: 2928 YIEAS------------SSHVTEGQTLDLNCVVPGQAHAQVTWYK-RGGSLPARHQTHGS 2974
Query: 321 NLTLEGVTRGQSGTYGCRVE-----DYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLP 375
L L V+ SG Y CR + +A+ V + + P+ + ++
Sbjct: 2975 QLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQ 3034
Query: 376 LNSSAVVNCSVHGLPTP-ALRWTKDSTPLGD-------GPMLSLSSITFDSNGTYVCEAS 427
A C +H P +L W + L D G ++++ ++GTY C AS
Sbjct: 3035 QGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVAS 3094
Query: 428 LPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQ 487
V N L V G P T + P+ + G VTL C + G P W++
Sbjct: 3095 -NAYGVAQSVVN--LSVHGPP---TVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTR 3148
Query: 488 LGGSPAEPIPGRQGWVSSSLTLKVTSALSRDG--ISCEASNPHGNKRH----VFHFGTVS 541
+ +PA+ G + S L+++SA D C A N G + + G ++
Sbjct: 3149 ISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMA 3208
Query: 542 PQTSQAGVAVMAVAVSVG 559
P Q + V G
Sbjct: 3209 PGAPQVQAEEAELTVEAG 3226
Score = 61.6 bits (148), Expect = 2e-09
Identities = 109/469 (23%), Positives = 168/469 (35%), Gaps = 78/469 (16%)
Query: 91 TMHDTRGRSP-PYQLDSQG-RLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPE 148
T+H ++ RSP P+Q +G L++ D Y+C + AG AEAT L+V + P
Sbjct: 3242 TIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATS-PAGHAEATIILHVESPPY 3300
Query: 149 ATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRT 208
AT V + + Q +A +G P W R G L E R
Sbjct: 3301 ATTVPEHASVQAGETVQLQCLA-----HGTPPLTFQWSRVGSSLPGRATARNELLHFERA 3355
Query: 209 VREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRL--------DSPTFHLTL 260
E SG R R ++ S A L +G G L +PT +T
Sbjct: 3356 APEDSGRY--------RCRVTNKVGSAEAFAQL-LVQGPPGSLPATSIPAGSTPTVQVTP 3406
Query: 261 HYPTEH----VQFWVGSPS---TPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEV 313
T+ V+F PS T W +EG G P +++
Sbjct: 3407 QLETKSIGASVEFHCAVPSDRGTQLRWFKEG----------GQLPPGHSV---------- 3446
Query: 314 LNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLS 373
+G L ++ + + GTY C+ ++ + L + S V +
Sbjct: 3447 ----QDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTS---VQT 3499
Query: 374 LPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGPMLS-----LSSITFDSNGTYVCEASL 428
+ + + C G P P + W+K L G + S ++ + G Y C A
Sbjct: 3500 VVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTA-- 3557
Query: 429 PTVPVLSRTQNFTLLVQGSPELKTA-EIEPKADGSWREGDEVTLICSARGHPDPKLSWSQ 487
T + + LLVQ P++ E+ A G C A G+P P +SWS+
Sbjct: 3558 -TNAAGTTQSHVLLLVQALPQISMPQEVRVPA------GSAAVFPCIASGYPTPDISWSK 3610
Query: 488 LGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFH 536
L GS +P ++ L L C A+N G + H
Sbjct: 3611 LDGS----LPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAH 3655
Score = 57.0 bits (136), Expect = 5e-08
Identities = 107/463 (23%), Positives = 162/463 (34%), Gaps = 62/463 (13%)
Query: 89 QVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPE 148
QVT + G P RL + +A D YVC A+ EA+ + V
Sbjct: 2275 QVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVC----RASNGMEASITVTVTGTQG 2330
Query: 149 ATEVSPNKGTLSV-MEDSAQEIATCNSRN------GNPAPKITWYRNGQRLEVPVEMNPE 201
A P T + +E S+ ++A + + G ++TW++ G L PV
Sbjct: 2331 ANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL--PVRHQTH 2388
Query: 202 GYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLH 261
G + + +AS S + +AS P G P +T
Sbjct: 2389 GSLLR--LYQASPADSGEYVCRVLGSSVPLEASVLVTIE---PAG-----SVPALGVT-- 2436
Query: 262 YPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGN 321
PT ++ + + V EG T+ L C G + T + V+
Sbjct: 2437 -PTVRIE-------SSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH-GSR 2487
Query: 322 LTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELR--------VAYLDPLELSEGKVLS 373
L L VT SG Y CRV + + T++ R VAY P+ + E S
Sbjct: 2488 LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAY--PVRI-ESSSAS 2544
Query: 374 LPLNSSAVVNCSVHGLPTPALRWTKDSTPLGD-----GPMLSLSSITFDSNGTYVCEASL 428
L + +NC V + W K L G L + +T +G YVC S
Sbjct: 2545 LANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSN 2604
Query: 429 PTVPVLSRTQNFTLLVQGSPELKTAEIEP-----KADGSWREGDEVTLICSARGHPDPKL 483
SR + + +QGS + P + + EG + L C P +
Sbjct: 2605 GAG---SRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAII 2661
Query: 484 SWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASN 526
+W + GGS +P R S L L S C A+N
Sbjct: 2662 TWYKRGGS----LPSRHQTHGSHLRLHQMSVADSGEYVCRANN 2700
Score = 52.4 bits (124), Expect = 1e-06
Identities = 101/446 (22%), Positives = 159/446 (35%), Gaps = 73/446 (16%)
Query: 108 GRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKP-EATEVSPNKGTLSVMEDSA 166
G L L + D+ Y+C + +AG A A L+V +VSP + + +
Sbjct: 1916 GILRLPAVEPTDQAQYLCRAHS-SAGQQVARAVLHVHGGGGPRVQVSPERTQVH----AG 1970
Query: 167 QEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRL 226
+ + G P+ ITW + G L P + RT + ++T+
Sbjct: 1971 RTVRLYCRAAGVPSATITWRKEGGSL-------PPQARSERTDIATLLIPAITTA----- 2018
Query: 227 RKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDT 286
DA F+ S R+ + P V+ SPS V EG T
Sbjct: 2019 -----DAGFYLCVATSPAGTAQARIQVVVLSASDASPPP-VKIESSSPS-----VTEGQT 2067
Query: 287 VQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAAD 346
+ L C GS + T +R V+ L L V+ SG Y CRVE+
Sbjct: 2068 LDLNCVVAGSAHAQVTWYRRGGSLPPHTQVH-GSRLRLPQVSPADSGEYVCRVENGSGPK 2126
Query: 347 DVQLSKTL---------------ELRVAYLDPLE--LSEGKVLSLPLNSSAVVNCSVHGL 389
+ ++ ++ R ++P ++EG+ L L NC V G
Sbjct: 2127 EASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDL--------NCVVPGQ 2178
Query: 390 PTPALRWTKDSTPLG-----DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLV 444
+ W K L G +L L +T +G YVC + P+ + ++LV
Sbjct: 2179 AHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEA-----SVLV 2233
Query: 445 QGSPELKTAEIEP----KADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQ 500
+ I P + + EG + L C G +++W + GGS +P R
Sbjct: 2234 TIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGS----LPARH 2289
Query: 501 GWVSSSLTLKVTSALSRDGISCEASN 526
S L + S C ASN
Sbjct: 2290 QVRGSRLYIFQASPADAGQYVCRASN 2315
Score = 49.3 bits (116), Expect = 1e-05
Identities = 107/458 (23%), Positives = 171/458 (37%), Gaps = 74/458 (16%)
Query: 89 QVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVF---- 144
QVT + G PP+ RL L + D +YVC V G+ G EA+ ++V
Sbjct: 2081 QVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGS-GPKEASITVSVLHGTH 2139
Query: 145 AKPEATEVSPNKGTLSVMEDSAQEIATCNSRN------GNPAPKITWYRNGQRLEVPVEM 198
+ P T V + + + E S+ +A + + G ++TW++ G L
Sbjct: 2140 SGPSYTPVPGSTRPIRI-EPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL------ 2192
Query: 199 NPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHL 258
P + T ++ LRL + S H G G L++ +
Sbjct: 2193 -PARHQTHGSL--------------LRLHQVTPADSGEYVCHVV---GTSGPLEASVL-V 2233
Query: 259 TLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNL 318
T+ + + V EG T+ L C G + T ++ V
Sbjct: 2234 TIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR- 2292
Query: 319 EGNLTLEGVTRGQSGTYGCRVED-YDAADDVQLSKTLELRVAY---------LDPL--EL 366
L + + +G Y CR + +A+ V ++ T +AY ++P ++
Sbjct: 2293 GSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQV 2352
Query: 367 SEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLG-----DGPMLSLSSITFDSNGT 421
+EG+ L L NC V G + W K L G +L L + +G
Sbjct: 2353 AEGQTLDL--------NCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGE 2404
Query: 422 YVCEASLPTVPVLSRTQNFTLLVQGS-PEL---KTAEIEPKADGSWREGDEVTLICSARG 477
YVC +VP L + T+ GS P L T IE + EG + L C G
Sbjct: 2405 YVCRVLGSSVP-LEASVLVTIEPAGSVPALGVTPTVRIE-SSSSQVAEGQTLDLNCLVAG 2462
Query: 478 HPDPKLSWSQLGGSPAEPIPGRQGWVSSSL-TLKVTSA 514
+++W + GGS +P R S L L+VT A
Sbjct: 2463 QAHAQVTWHKRGGS----LPARHQVHGSRLRLLQVTPA 2496
Score = 46.6 bits (109), Expect = 6e-05
Identities = 101/468 (21%), Positives = 157/468 (33%), Gaps = 61/468 (13%)
Query: 89 QVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPE 148
QVT H G P RL L + D +YVC V G++GT EA+ + + +
Sbjct: 2467 QVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRV-VGSSGTQEASVLVTIQQRLS 2525
Query: 149 ATEVSPNKGTLSVMEDSAQ----EIATCNSRNGNPAPK-ITWYRNGQRLEVPVEMNPEGY 203
+ + + SA N + AP ITWY+ G L ++
Sbjct: 2526 GSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRL 2585
Query: 204 MTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYP 263
+ SG ++ R+ S S H SP + P
Sbjct: 2586 RIPQVTPADSG----EYVCHVSNGAGSRETSLIVTIQGS--GSSHVPSVSPPIRIESSSP 2639
Query: 264 TEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLT 323
T V EG T+ L C P T ++ + +L
Sbjct: 2640 T----------------VVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH-GSHLR 2682
Query: 324 LEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAV-- 381
L ++ SG Y CR + D ++ S + + + P + + +SS V
Sbjct: 2683 LHQMSVADSGEYVCRANNN--IDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAE 2740
Query: 382 -----VNCSVHGLPTPALRWTKDSTPLGD-----GPMLSLSSITFDSNGTYVC------- 424
+NC V G + W K L G L L ++ +G YVC
Sbjct: 2741 GETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSG 2800
Query: 425 --EAS-LPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDP 481
EAS L T+ + G+P ++ IEP + EG + L C G
Sbjct: 2801 PLEASVLVTIEASGSSAVHVPAPGGAPPIR---IEPSSSRV-AEGQTLDLKCVVPGQAHA 2856
Query: 482 KLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHG 529
+++W + GG+ +P R L L S SC+ + G
Sbjct: 2857 QVTWHKRGGN----LPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSG 2900
Score = 42.0 bits (97), Expect = 0.002
Identities = 91/430 (21%), Positives = 161/430 (37%), Gaps = 55/430 (12%)
Query: 86 SELQVTMHDTRGRSPPYQLDSQGRLV-LAEAQVGDERDYVCVVRAGAAGTAEATARLNVF 144
S QVT H RG S P + + G L+ L +A D +YVC V G++ EA+ + +
Sbjct: 2368 SHAQVTWHK-RGGSLPVRHQTHGSLLRLYQASPADSGEYVCRV-LGSSVPLEASVLVTI- 2424
Query: 145 AKPEATEVSPNKGTLSVMEDSAQEIATCNSRN------GNPAPKITWYRNGQRLEVPVEM 198
+P + + +E S+ ++A + + G ++TW++ G L ++
Sbjct: 2425 -EPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQV 2483
Query: 199 NPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHL 258
+ + SG + ++AS L G H
Sbjct: 2484 HGSRLRLLQVTPADSG----EYVCRVVGSSGTQEASVLVTIQQRL-SGSH---------- 2528
Query: 259 TLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNL 318
++ V + V S+ A + G T+ L C S +P + + + +
Sbjct: 2529 -----SQGVAYPVRIESSSAS-LANGHTLDLNCLV-ASQAPHTITWYKRGGSLPSRHQIV 2581
Query: 319 EGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLE----LRVAYLDPLELSEGKVLSL 374
L + VT SG Y C V + + + L T++ V + P E ++
Sbjct: 2582 GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTV 2641
Query: 375 PLNSSAVVNCSVHGLPTPALRWTKDSTPLGD-----GPMLSLSSITFDSNGTYVCEAS-- 427
+ +NC V P + W K L G L L ++ +G YVC A+
Sbjct: 2642 VEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNN 2701
Query: 428 ---LPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWR---EGDEVTLICSARGHPDP 481
L V+S + + GSP + + + + S EG+ + L C G
Sbjct: 2702 IDALEASIVISVSPS-----AGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHA 2756
Query: 482 KLSWSQLGGS 491
+++W + GGS
Sbjct: 2757 QVTWHKRGGS 2766
Score = 39.7 bits (91), Expect = 0.008
Identities = 42/163 (25%), Positives = 62/163 (38%), Gaps = 16/163 (9%)
Query: 374 LPLNSSAVVNCSVHGLPTPALRWTKDS---TPLG-----DGPMLSLSSITFDSNGTYVCE 425
+P S + C V G P W+++ P G G L S+ G Y+C
Sbjct: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICT 1747
Query: 426 ASLPTVPVLSRTQNFTLLVQGSPELK-TAEIEPKADGSWREGDEVTLICSARG-HPDPKL 483
SR + LLV +P T +E + S R G +VT IC+A+ P L
Sbjct: 1748 CRNLHQSNTSRAE---LLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTL 1804
Query: 484 SWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASN 526
W++L +P R + LT++ C SN
Sbjct: 1805 VWTRLHNG---KLPTRAMDFNGILTIRNVQLSDAGTYVCTGSN 1844
Score = 33.9 bits (76), Expect = 0.43
Identities = 39/160 (24%), Positives = 59/160 (36%), Gaps = 21/160 (13%)
Query: 89 QVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPE 148
QVT G P + S G + +A ++ D Y C AAGT ++ L V A P+
Sbjct: 3519 QVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTA-TNAAGTTQSHVLLLVQALPQ 3577
Query: 149 AT---EVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMT 205
+ EV G+ +V A +G P P I+W + L + M
Sbjct: 3578 ISMPQEVRVPAGSAAVFPCIA---------SGYPTPDISWSKLDGSLPPDSRLENNMLML 3628
Query: 206 SRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPE 245
+ +G T+T +R AH +PE
Sbjct: 3629 PSVRPQDAGTYVCTAT--------NRQGKVKAFAHLQVPE 3660
>gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]
Length = 708
Score = 79.3 bits (194), Expect = 9e-15
Identities = 91/326 (27%), Positives = 135/326 (41%), Gaps = 35/326 (10%)
Query: 105 DSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMED 164
+ Q L + ++ DE Y C +A AG A+L+V PEA +V V
Sbjct: 83 NGQHDLHIRPVELEDEASYEC--QATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGV 140
Query: 165 SAQEIATCNSR-NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
A TC SR + P P++ W+R+G L+ G +T+ + S+ STL
Sbjct: 141 PAN--LTCRSRGDARPTPELLWFRDGVLLD--------GATFHQTLLKEGTPGSVESTLT 190
Query: 224 LRLRKDDRDASFHCAAH-YSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVR 282
L D A+F C A +LP GR + L+L YP E SP T V+
Sbjct: 191 LTPFSHDDGATFVCRARSQALPTGRDTAIT-----LSLQYPPEVTLS--ASPHT----VQ 239
Query: 283 EGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDY 342
EG+ V LC+ + P T +R VL LE V T E
Sbjct: 240 EGEKVIFLCQA--TAQPPVTGYRWAKGGSPVLGAR---GPRLEVVADASFLTEPVSCEVS 294
Query: 343 DAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK--DS 400
+A S L++ P+ ++ + +S+ + A +C+ G P P + WT+ +
Sbjct: 295 NAVGSANRSTALDV---LFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGA 351
Query: 401 TPLGDGPMLSLSSITFDSNGTYVCEA 426
LG G L L S+ + G YVC A
Sbjct: 352 QVLGSGATLRLPSVGPEDAGDYVCRA 377
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/303 (23%), Positives = 115/303 (37%), Gaps = 72/303 (23%)
Query: 222 LYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWV 281
L++R + + +AS+ C A + R +L H+ + P E Q +G PS +
Sbjct: 88 LHIRPVELEDEASYECQATQAGLRSRPAQL-----HVLV--PPEAPQV-LGGPSVS---L 136
Query: 282 REGDTVQLLCR--GDGSPSPEYTLFR----------LQDEQEEVLNVNLEGNLTLEGVTR 329
G L CR GD P+PE FR Q +E ++E LTL +
Sbjct: 137 VAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSH 196
Query: 330 GQSGTYGCRVEDYDAADDVQLSKTLELR-----VAYLDPLELSEGKVLSLPLNSSAVVNC 384
T+ CR + TL L+ P + EG+ + ++A
Sbjct: 197 DDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQP-- 254
Query: 385 SVHGLPTPALRWTKDSTPL--GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQN--- 439
P RW K +P+ GP L + V +AS T PV N
Sbjct: 255 -----PVTGYRWAKGGSPVLGARGPRLEV-----------VADASFLTEPVSCEVSNAVG 298
Query: 440 -----------FTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQL 488
F ++Q PE + ++ G++ + C+ RG+P P+++W++
Sbjct: 299 SANRSTALDVLFGPILQAKPEPVSVDV----------GEDASFSCAWRGNPLPRVTWTRR 348
Query: 489 GGS 491
GG+
Sbjct: 349 GGA 351
>gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens]
Length = 583
Score = 79.3 bits (194), Expect = 9e-15
Identities = 91/326 (27%), Positives = 135/326 (41%), Gaps = 35/326 (10%)
Query: 105 DSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMED 164
+ Q L + ++ DE Y C +A AG A+L+V PEA +V V
Sbjct: 33 NGQHDLHIRPVELEDEASYEC--QATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGV 90
Query: 165 SAQEIATCNSR-NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
A TC SR + P P++ W+R+G L+ G +T+ + S+ STL
Sbjct: 91 PAN--LTCRSRGDARPTPELLWFRDGVLLD--------GATFHQTLLKEGTPGSVESTLT 140
Query: 224 LRLRKDDRDASFHCAAH-YSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVR 282
L D A+F C A +LP GR + L+L YP E SP T V+
Sbjct: 141 LTPFSHDDGATFVCRARSQALPTGRDTAIT-----LSLQYPPEVTLS--ASPHT----VQ 189
Query: 283 EGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDY 342
EG+ V LC+ + P T +R VL LE V T E
Sbjct: 190 EGEKVIFLCQA--TAQPPVTGYRWAKGGSPVLGAR---GPRLEVVADASFLTEPVSCEVS 244
Query: 343 DAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK--DS 400
+A S L++ P+ ++ + +S+ + A +C+ G P P + WT+ +
Sbjct: 245 NAVGSANRSTALDV---LFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGA 301
Query: 401 TPLGDGPMLSLSSITFDSNGTYVCEA 426
LG G L L S+ + G YVC A
Sbjct: 302 QVLGSGATLRLPSVGPEDAGDYVCRA 327
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/303 (23%), Positives = 115/303 (37%), Gaps = 72/303 (23%)
Query: 222 LYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWV 281
L++R + + +AS+ C A + R +L H+ + P E Q +G PS +
Sbjct: 38 LHIRPVELEDEASYECQATQAGLRSRPAQL-----HVLV--PPEAPQV-LGGPSVS---L 86
Query: 282 REGDTVQLLCR--GDGSPSPEYTLFR----------LQDEQEEVLNVNLEGNLTLEGVTR 329
G L CR GD P+PE FR Q +E ++E LTL +
Sbjct: 87 VAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSH 146
Query: 330 GQSGTYGCRVEDYDAADDVQLSKTLELR-----VAYLDPLELSEGKVLSLPLNSSAVVNC 384
T+ CR + TL L+ P + EG+ + ++A
Sbjct: 147 DDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQP-- 204
Query: 385 SVHGLPTPALRWTKDSTPL--GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQN--- 439
P RW K +P+ GP L + V +AS T PV N
Sbjct: 205 -----PVTGYRWAKGGSPVLGARGPRLEV-----------VADASFLTEPVSCEVSNAVG 248
Query: 440 -----------FTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQL 488
F ++Q PE + ++ G++ + C+ RG+P P+++W++
Sbjct: 249 SANRSTALDVLFGPILQAKPEPVSVDV----------GEDASFSCAWRGNPLPRVTWTRR 298
Query: 489 GGS 491
GG+
Sbjct: 299 GGA 301
>gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens]
Length = 633
Score = 79.3 bits (194), Expect = 9e-15
Identities = 91/326 (27%), Positives = 135/326 (41%), Gaps = 35/326 (10%)
Query: 105 DSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMED 164
+ Q L + ++ DE Y C +A AG A+L+V PEA +V V
Sbjct: 83 NGQHDLHIRPVELEDEASYEC--QATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGV 140
Query: 165 SAQEIATCNSR-NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
A TC SR + P P++ W+R+G L+ G +T+ + S+ STL
Sbjct: 141 PAN--LTCRSRGDARPTPELLWFRDGVLLD--------GATFHQTLLKEGTPGSVESTLT 190
Query: 224 LRLRKDDRDASFHCAAH-YSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVR 282
L D A+F C A +LP GR + L+L YP E SP T V+
Sbjct: 191 LTPFSHDDGATFVCRARSQALPTGRDTAIT-----LSLQYPPEVTLS--ASPHT----VQ 239
Query: 283 EGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDY 342
EG+ V LC+ + P T +R VL LE V T E
Sbjct: 240 EGEKVIFLCQA--TAQPPVTGYRWAKGGSPVLGAR---GPRLEVVADASFLTEPVSCEVS 294
Query: 343 DAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK--DS 400
+A S L++ P+ ++ + +S+ + A +C+ G P P + WT+ +
Sbjct: 295 NAVGSANRSTALDV---LFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGA 351
Query: 401 TPLGDGPMLSLSSITFDSNGTYVCEA 426
LG G L L S+ + G YVC A
Sbjct: 352 QVLGSGATLRLPSVGPEDAGDYVCRA 377
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/303 (23%), Positives = 115/303 (37%), Gaps = 72/303 (23%)
Query: 222 LYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWV 281
L++R + + +AS+ C A + R +L H+ + P E Q +G PS +
Sbjct: 88 LHIRPVELEDEASYECQATQAGLRSRPAQL-----HVLV--PPEAPQV-LGGPSVS---L 136
Query: 282 REGDTVQLLCR--GDGSPSPEYTLFR----------LQDEQEEVLNVNLEGNLTLEGVTR 329
G L CR GD P+PE FR Q +E ++E LTL +
Sbjct: 137 VAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSH 196
Query: 330 GQSGTYGCRVEDYDAADDVQLSKTLELR-----VAYLDPLELSEGKVLSLPLNSSAVVNC 384
T+ CR + TL L+ P + EG+ + ++A
Sbjct: 197 DDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQP-- 254
Query: 385 SVHGLPTPALRWTKDSTPL--GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQN--- 439
P RW K +P+ GP L + V +AS T PV N
Sbjct: 255 -----PVTGYRWAKGGSPVLGARGPRLEV-----------VADASFLTEPVSCEVSNAVG 298
Query: 440 -----------FTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQL 488
F ++Q PE + ++ G++ + C+ RG+P P+++W++
Sbjct: 299 SANRSTALDVLFGPILQAKPEPVSVDV----------GEDASFSCAWRGNPLPRVTWTRR 348
Query: 489 GGS 491
GG+
Sbjct: 349 GGA 351
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 77.0 bits (188), Expect = 4e-14
Identities = 72/265 (27%), Positives = 111/265 (41%), Gaps = 24/265 (9%)
Query: 281 VREGDTVQLLCRGDGSPSPE----YTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYG 336
V G+TV CR +G+P PE + L E + LNV +G L + G Y
Sbjct: 245 VPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQ 304
Query: 337 CRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRW 396
C + A + S L P + + + + + +S + C G P P + W
Sbjct: 305 CMARN-SAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITW 363
Query: 397 TKDSTPLGDGPM-------LSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPE 449
T+D+ DG L L +IT +G + C A+ V + ++VQ P+
Sbjct: 364 TRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAA---NIIVQAPPQ 420
Query: 450 LKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTL 509
+ PK D E V +C A G+P P + W++ GG P+ G Q V SS TL
Sbjct: 421 F---TVTPK-DQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQ--LPVEG-QHTVLSSGTL 473
Query: 510 KVTSALSRD--GISCEASNPHGNKR 532
++ A D C+A + G K+
Sbjct: 474 RIDRAAQHDQGQYECQAVSSLGVKK 498
Score = 58.5 bits (140), Expect = 2e-08
Identities = 77/339 (22%), Positives = 125/339 (36%), Gaps = 64/339 (18%)
Query: 171 TCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDD 230
TC + GNP P+I W N L++ + T V + TL +R ++
Sbjct: 254 TCRAE-GNPKPEIIWIHNNHSLDLEDD-------TRLNVFD-------DGTLMIRNTRES 298
Query: 231 RDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLL 290
+ C A S E + T L Y + P+ P+ ++ DT L+
Sbjct: 299 DQGVYQCMARNSAGEAK-------TQSAMLRYSS--------LPAKPSFVIQPQDTEVLI 343
Query: 291 -------CRGDGSPSPEYTLFRLQD-EQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVED- 341
C G P P T R E + +V L L+ +T+ G + C +
Sbjct: 344 GTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNS 403
Query: 342 ---YDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK 398
AA ++ + + V D + L E V L C G P P + WTK
Sbjct: 404 HGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWL---------CEADGNPPPVIVWTK 454
Query: 399 DSTPL---GDGPMLSLSSITFD-----SNGTYVCEASLPTVPVLSRTQNFTLLVQGSPEL 450
L G +LS ++ D G Y C+A + ++ V + T+ P+
Sbjct: 455 TGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQA-VSSLGVKKVSVQLTV----KPKA 509
Query: 451 KTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
+ D S G + + C A+G P P ++W++ G
Sbjct: 510 LAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEG 548
Score = 53.1 bits (126), Expect = 7e-07
Identities = 80/334 (23%), Positives = 121/334 (36%), Gaps = 54/334 (16%)
Query: 108 GRLVLAEAQVGDERDYVCVVR--AGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDS 165
G L++ + D+ Y C+ R AG A T A R + + + P + + +
Sbjct: 288 GTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTST 347
Query: 166 AQEIATCNSRNGNPAPKITWYR-NGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYL 224
E G+P P ITW R NG L+ SR V +SGL YL
Sbjct: 348 TLECMA----TGHPHPLITWTRDNGLELD-----------GSRHVATSSGL-------YL 385
Query: 225 RLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWV-RE 283
+ F C A+ S HG + + + P QF V TP V E
Sbjct: 386 QNITQRDHGRFTCHANNS-----HGTVQAAANIIVQAPP----QFTV----TPKDQVVLE 432
Query: 284 GDTVQLLCRGDGSPSPE--YTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVED 341
V+ LC DG+P P +T Q E V G L ++ + G Y C+
Sbjct: 433 EHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVS 492
Query: 342 YDAADDVQLSKTLELR-VAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDS 400
V + T++ + +A L S+ + + ++C G P P + W K+
Sbjct: 493 SLGVKKVSVQLTVKPKALAVFTQLPQDT----SVEVGKNINISCHAQGEPQPIITWNKEG 548
Query: 401 TPL--------GDGPMLSLSSITFDSNGTYVCEA 426
+ D L++ F G Y C A
Sbjct: 549 VQITESGKFHVDDEGTLTIYDAGFPDQGRYECVA 582
Score = 50.4 bits (119), Expect = 4e-06
Identities = 45/172 (26%), Positives = 68/172 (39%), Gaps = 15/172 (8%)
Query: 368 EGKVLSLPLNSSAVVNCSVHGLPTPALRWT--------KDSTPLG--DGPMLSLSSITFD 417
E + + +P ++ C G P P + W +D T L D L + +
Sbjct: 239 EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
Query: 418 SNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARG 477
G Y C A ++TQ+ L P + I+P+ D G TL C A G
Sbjct: 299 DQGVYQCMARNSAGE--AKTQSAMLRYSSLPAKPSFVIQPQ-DTEVLIGTSTTLECMATG 355
Query: 478 HPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHG 529
HP P ++W++ G E R SS L L+ + +C A+N HG
Sbjct: 356 HPHPLITWTRDNG--LELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHG 405
Score = 44.7 bits (104), Expect = 2e-04
Identities = 76/302 (25%), Positives = 110/302 (36%), Gaps = 59/302 (19%)
Query: 38 PPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRG 97
P EV+ G S L+C TG H H ++ W G EL + H
Sbjct: 336 PQDTEVLIGTSTTLECMATG-HPHPLITW--------------TRDNGLELDGSRH---- 376
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
+ + L L D + C + GT +A A + V A P+ T V+P
Sbjct: 377 ------VATSSGLYLQNITQRDHGRFTCHAN-NSHGTVQAAANIIVQAPPQFT-VTPKDQ 428
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
V+E+ A E C + +GNP P I W + G +L V EG T +LS
Sbjct: 429 V--VLEEHAVE-WLCEA-DGNPPPVIVWTKTGGQLPV------EGQHT---------VLS 469
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
+ TL + + C A SL + + LT+ P F T
Sbjct: 470 -SGTLRIDRAAQHDQGQYECQAVSSL------GVKKVSVQLTVK-PKALAVFTQLPQDTS 521
Query: 278 AGWVREGDTVQLLCRGDGSPSPEYTLFR--LQDEQEEVLNVNLEGNLTLEGVTRGQSGTY 335
V G + + C G P P T + +Q + +V+ EG LT+ G Y
Sbjct: 522 ---VEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRY 578
Query: 336 GC 337
C
Sbjct: 579 EC 580
>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
sapiens]
Length = 848
Score = 75.9 bits (185), Expect = 1e-13
Identities = 108/480 (22%), Positives = 178/480 (37%), Gaps = 89/480 (18%)
Query: 37 VPPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTR 96
VP E+ G+S C G + WF + P + V +D
Sbjct: 25 VPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQ-------QRISVVWND-- 75
Query: 97 GRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNK 156
DS L + A + D Y CVV +EAT + +F K + N
Sbjct: 76 --------DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKL----MFKNA 123
Query: 157 GTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLL 216
T + + C+ + P P I W G+ + + + VR
Sbjct: 124 PTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDV-----------ILKKDVR-----F 166
Query: 217 SLTSTLYLRLR--KDDRDASFHCAAHYSLPEGR---HGRLDSPTFHLTLHYPTEHVQFWV 271
+ S YL++R K + ++ C EGR G ++ + ++ P +Q
Sbjct: 167 IVLSNNYLQIRGIKKTDEGTYRC-------EGRILARGEINFKDIQVIVNVPPT-IQARQ 218
Query: 272 GSPSTPAGWVREGDTVQLLCRGDGSPSP--EYTLFRLQDEQEE----VLNVNLEGNLTLE 325
+ A G +V L+C +G P P +T Q EQEE + + LT++
Sbjct: 219 NIVNATANL---GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK 275
Query: 326 GVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCS 385
V + Y C E+ D T+ L+V + E + ++ L + C
Sbjct: 276 KVDKNDEAEYICIAENKAGEQDA----TIHLKVFAKPKITYVENQT-AMELEEQVTLTCE 330
Query: 386 VHGLPTPALRWTKDSTPLG------DGPM----------LSLSSITFDSNGTYVCEASLP 429
G P P++ W + + DG M L+L SI + G Y+C AS
Sbjct: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 390
Query: 430 TVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
+ +Q+ L VQ +P+L+ P A +W EG++V + C +P +SW + G
Sbjct: 391 ---IGQDSQSMYLEVQYAPKLQG----PVAVYTW-EGNQVNITCEVFAYPSATISWFRDG 442
Score = 49.3 bits (116), Expect = 1e-05
Identities = 67/296 (22%), Positives = 111/296 (37%), Gaps = 37/296 (12%)
Query: 282 REGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLN-----VNLEGN-LTLEGVTRGQSGTY 335
REG+ ++C S P T+ ++ +L + L N L + G+ + GTY
Sbjct: 130 REGEDAVIVCDVVSSLPP--TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTY 187
Query: 336 GCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKV-LSLPLNSSAVVNCSVHGLPTPAL 394
C A ++ K +++ V ++ + V + L S + C G P P +
Sbjct: 188 RCEGRIL-ARGEINF-KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTM 245
Query: 395 RWTKDSTPL------------GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTL 442
WTKD + D L++ + + Y+C A + Q+ T+
Sbjct: 246 SWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENK-----AGEQDATI 300
Query: 443 LVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSW---SQLGGSPAEPIPG- 498
++ + K +E + E +VTL C A G P P ++W ++ S + + G
Sbjct: 301 HLKVFAKPKITYVENQTAMELEE--QVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGH 358
Query: 499 ---RQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAV 551
R SSLTLK C ASN G + Q VAV
Sbjct: 359 MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAV 414
Score = 47.0 bits (110), Expect = 5e-05
Identities = 58/243 (23%), Positives = 95/243 (39%), Gaps = 32/243 (13%)
Query: 313 VLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAAD-----DVQLSKTLELRVAYLDPLELS 367
V N + LT+ +G Y C V D ++ +V++ + L + A P E
Sbjct: 72 VWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPT-PQEFR 130
Query: 368 EGKVLSLPLNSSAVVNCSVHGLPTPALRWT---KDSTPLGDGPMLSLSS-------ITFD 417
EG+ AV+ C V P + W +D D + LS+ I
Sbjct: 131 EGE--------DAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKT 182
Query: 418 SNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARG 477
GTY CE + ++ ++ ++V P ++ + A + G VTL+C A G
Sbjct: 183 DEGTYRCEGRILARGEIN-FKDIQVIVNVPPTIQARQNIVNATANL--GQSVTLVCDAEG 239
Query: 478 HPDPKLSWSQLGGSPAEPIPGRQGWV----SSSLTLKVTSALSRDGISCEASNPHGNKRH 533
P+P +SW++ G E + ++ SS LT+K C A N G +
Sbjct: 240 FPEPTMSWTK-DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDA 298
Query: 534 VFH 536
H
Sbjct: 299 TIH 301
Score = 46.6 bits (109), Expect = 6e-05
Identities = 82/377 (21%), Positives = 140/377 (37%), Gaps = 67/377 (17%)
Query: 119 DERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGN 178
DE Y C R A G + P + N ++ + Q + G
Sbjct: 183 DEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQN--IVNATANLGQSVTLVCDAEGF 240
Query: 179 PAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCA 238
P P ++W ++G+++E E + E Y+ S + L ++K D++ A
Sbjct: 241 PEPTMSWTKDGEQIE--QEEDDEKYIFS------------DDSSQLTIKKVDKNDE---A 283
Query: 239 AHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPS 298
+ + E + G D+ T HL + + + + + + + V L C G P
Sbjct: 284 EYICIAENKAGEQDA-TIHLKV-FAKPKITYVENQTA-----MELEEQVTLTCEASGDPI 336
Query: 299 PEY---TLFRLQDEQEEVLNVNL-------EGNLTLEGVTRGQSGTYGCRVEDYDAADDV 348
P T R +E+ L+ ++ +LTL+ + +G Y C + D
Sbjct: 337 PSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD-- 394
Query: 349 QLSKTLELRVAYLDPLELSEGKVLSLPLNSSAV-VNCSVHGLPTPALRWTKDSTPLGDG- 406
S+++ L V Y L +G V + V + C V P+ + W +D L
Sbjct: 395 --SQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSN 449
Query: 407 ---------PMLSLSSITFDSN---GTYVCEA-------SLPTVPVLSRTQNFTLLVQGS 447
P S +T DS G Y C A SL + V + T + + Q
Sbjct: 450 YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVE 509
Query: 448 PELKTAEI---EPKADG 461
P TA++ EP+A G
Sbjct: 510 PYSSTAQVQFDEPEATG 526
>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
sapiens]
Length = 761
Score = 75.9 bits (185), Expect = 1e-13
Identities = 108/480 (22%), Positives = 178/480 (37%), Gaps = 89/480 (18%)
Query: 37 VPPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTR 96
VP E+ G+S C G + WF + P + V +D
Sbjct: 25 VPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQ-------QRISVVWND-- 75
Query: 97 GRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNK 156
DS L + A + D Y CVV +EAT + +F K + N
Sbjct: 76 --------DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKL----MFKNA 123
Query: 157 GTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLL 216
T + + C+ + P P I W G+ + + + VR
Sbjct: 124 PTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDV-----------ILKKDVR-----F 166
Query: 217 SLTSTLYLRLR--KDDRDASFHCAAHYSLPEGR---HGRLDSPTFHLTLHYPTEHVQFWV 271
+ S YL++R K + ++ C EGR G ++ + ++ P +Q
Sbjct: 167 IVLSNNYLQIRGIKKTDEGTYRC-------EGRILARGEINFKDIQVIVNVPPT-IQARQ 218
Query: 272 GSPSTPAGWVREGDTVQLLCRGDGSPSP--EYTLFRLQDEQEE----VLNVNLEGNLTLE 325
+ A G +V L+C +G P P +T Q EQEE + + LT++
Sbjct: 219 NIVNATANL---GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK 275
Query: 326 GVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCS 385
V + Y C E+ D T+ L+V + E + ++ L + C
Sbjct: 276 KVDKNDEAEYICIAENKAGEQDA----TIHLKVFAKPKITYVENQT-AMELEEQVTLTCE 330
Query: 386 VHGLPTPALRWTKDSTPLG------DGPM----------LSLSSITFDSNGTYVCEASLP 429
G P P++ W + + DG M L+L SI + G Y+C AS
Sbjct: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 390
Query: 430 TVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
+ +Q+ L VQ +P+L+ P A +W EG++V + C +P +SW + G
Sbjct: 391 ---IGQDSQSMYLEVQYAPKLQG----PVAVYTW-EGNQVNITCEVFAYPSATISWFRDG 442
Score = 49.3 bits (116), Expect = 1e-05
Identities = 67/296 (22%), Positives = 111/296 (37%), Gaps = 37/296 (12%)
Query: 282 REGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLN-----VNLEGN-LTLEGVTRGQSGTY 335
REG+ ++C S P T+ ++ +L + L N L + G+ + GTY
Sbjct: 130 REGEDAVIVCDVVSSLPP--TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTY 187
Query: 336 GCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKV-LSLPLNSSAVVNCSVHGLPTPAL 394
C A ++ K +++ V ++ + V + L S + C G P P +
Sbjct: 188 RCEGRIL-ARGEINF-KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTM 245
Query: 395 RWTKDSTPL------------GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTL 442
WTKD + D L++ + + Y+C A + Q+ T+
Sbjct: 246 SWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENK-----AGEQDATI 300
Query: 443 LVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSW---SQLGGSPAEPIPG- 498
++ + K +E + E +VTL C A G P P ++W ++ S + + G
Sbjct: 301 HLKVFAKPKITYVENQTAMELEE--QVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGH 358
Query: 499 ---RQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAV 551
R SSLTLK C ASN G + Q VAV
Sbjct: 359 MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAV 414
Score = 47.0 bits (110), Expect = 5e-05
Identities = 58/243 (23%), Positives = 95/243 (39%), Gaps = 32/243 (13%)
Query: 313 VLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAAD-----DVQLSKTLELRVAYLDPLELS 367
V N + LT+ +G Y C V D ++ +V++ + L + A P E
Sbjct: 72 VWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPT-PQEFR 130
Query: 368 EGKVLSLPLNSSAVVNCSVHGLPTPALRWT---KDSTPLGDGPMLSLSS-------ITFD 417
EG+ AV+ C V P + W +D D + LS+ I
Sbjct: 131 EGE--------DAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKT 182
Query: 418 SNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARG 477
GTY CE + ++ ++ ++V P ++ + A + G VTL+C A G
Sbjct: 183 DEGTYRCEGRILARGEIN-FKDIQVIVNVPPTIQARQNIVNATANL--GQSVTLVCDAEG 239
Query: 478 HPDPKLSWSQLGGSPAEPIPGRQGWV----SSSLTLKVTSALSRDGISCEASNPHGNKRH 533
P+P +SW++ G E + ++ SS LT+K C A N G +
Sbjct: 240 FPEPTMSWTK-DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDA 298
Query: 534 VFH 536
H
Sbjct: 299 TIH 301
Score = 46.6 bits (109), Expect = 6e-05
Identities = 82/377 (21%), Positives = 140/377 (37%), Gaps = 67/377 (17%)
Query: 119 DERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGN 178
DE Y C R A G + P + N ++ + Q + G
Sbjct: 183 DEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQN--IVNATANLGQSVTLVCDAEGF 240
Query: 179 PAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCA 238
P P ++W ++G+++E E + E Y+ S + L ++K D++ A
Sbjct: 241 PEPTMSWTKDGEQIE--QEEDDEKYIFS------------DDSSQLTIKKVDKNDE---A 283
Query: 239 AHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPS 298
+ + E + G D+ T HL + + + + + + + V L C G P
Sbjct: 284 EYICIAENKAGEQDA-TIHLKV-FAKPKITYVENQTA-----MELEEQVTLTCEASGDPI 336
Query: 299 PEY---TLFRLQDEQEEVLNVNL-------EGNLTLEGVTRGQSGTYGCRVEDYDAADDV 348
P T R +E+ L+ ++ +LTL+ + +G Y C + D
Sbjct: 337 PSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD-- 394
Query: 349 QLSKTLELRVAYLDPLELSEGKVLSLPLNSSAV-VNCSVHGLPTPALRWTKDSTPLGDG- 406
S+++ L V Y L +G V + V + C V P+ + W +D L
Sbjct: 395 --SQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSN 449
Query: 407 ---------PMLSLSSITFDSN---GTYVCEA-------SLPTVPVLSRTQNFTLLVQGS 447
P S +T DS G Y C A SL + V + T + + Q
Sbjct: 450 YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVE 509
Query: 448 PELKTAEI---EPKADG 461
P TA++ EP+A G
Sbjct: 510 PYSSTAQVQFDEPEATG 526
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 75.5 bits (184), Expect = 1e-13
Identities = 122/541 (22%), Positives = 187/541 (34%), Gaps = 103/541 (19%)
Query: 41 VEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSP 100
+ V G +V L C G + W L +++ + S QGS V D
Sbjct: 1755 ITVHSGSTVELKCRAEGRPSP-TVTWILANQT-----VVSESSQGSRQAVVTVD------ 1802
Query: 101 PYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLS 160
G LVL + D Y CV + G ++ V A P + +
Sbjct: 1803 -------GTLVLHNLSIYDRGFYKCVA-SNPGGQDSLLVKIQVIAAPPVILEQRRQVIVG 1854
Query: 161 VMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTS 220
+S + T G P P + W L E+ P + S+ ++G
Sbjct: 1855 TWGESLKLPCTAK---GTPQPSVYWV-----LSDGTEVKPLQFTNSKLFLFSNG------ 1900
Query: 221 TLYLRLRKDDRDASFHCAAHYSLPEGRH-------GRLDSPTFHLTLHYPTEHVQFWVGS 273
TLY+R ++ C A S R R+ SP TE
Sbjct: 1901 TLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTE-------- 1952
Query: 274 PSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQ-----DEQEEV---LNVNLEGNLTLE 325
V GD + L C G P P+ ++RL D+Q V ++V G+L +
Sbjct: 1953 -------VNFGDKLLLNCSATGEPKPQI-MWRLPSKAVVDQQHRVGSWIHVYPNGSLFIG 2004
Query: 326 GVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCS 385
VT SG Y C + D + + +L L+ A +D + +VL V+C
Sbjct: 2005 SVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLH---GKDFQVDCK 2061
Query: 386 VHGLPTPALRWTKDSTPLGDGPMLSLSSITFDS-----------NGT------------- 421
G P P + W+ L DG M++ + DS NGT
Sbjct: 2062 ASGSPVPEISWS-----LPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGD 2116
Query: 422 YVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDP 481
Y C A T+ + T++ +P ++ + K + + GD L C G P P
Sbjct: 2117 YTCYAQ-NTLGKDEMKVHLTVIT-AAPRIRQSN---KTNKRIKAGDTAVLDCEVTGDPKP 2171
Query: 482 KLSWSQLGGSPAEPIPGRQGW-VSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTV 540
K+ W R + + SLT+ L C A NP G+ ++ V
Sbjct: 2172 KIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVV 2231
Query: 541 S 541
S
Sbjct: 2232 S 2232
Score = 61.6 bits (148), Expect = 2e-09
Identities = 112/520 (21%), Positives = 184/520 (35%), Gaps = 85/520 (16%)
Query: 42 EVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPP 101
+V+ GK +DC +G+ + W L D + + + MQ D+ R+
Sbjct: 2049 QVLHGKDFQVDCKASGSPVPE-ISWSLPDGT-----MINNAMQAD-------DSGHRTRR 2095
Query: 102 YQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSV 161
Y L + G L + V +E DY C + G E L V A + + T
Sbjct: 2096 YTLFNNGTLYFNKVGVAEEGDYTCYAQ-NTLGKDEMKVHLTVITA--APRIRQSNKTNKR 2152
Query: 162 MEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTST 221
++ + C G+P PKI W + + R A+G L++
Sbjct: 2153 IKAGDTAVLDCEV-TGDPKPKIFWLLPSNDMI--------SFSIDRYTFHANGSLTINKV 2203
Query: 222 LYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHL-TLHYPTEHVQFWVGSPSTPAGW 280
L + C A P G D+ + L + P + A
Sbjct: 2204 KLLD------SGEYVCVARN--PSGD----DTKMYKLDVVSKPPLINGLYTNRTVIKATA 2251
Query: 281 VREGDTVQLLCRGDGSPSPEY------TLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGT 334
VR CR +G+PSPE +F + V+ G L + V S
Sbjct: 2252 VRHSKK-HFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSAD 2310
Query: 335 YGC--RVEDYDAADDVQLSKTLEL--RVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLP 390
+ C R E ++ VQL + LE+ R + +P + + L S +NCSV G P
Sbjct: 2311 FICVARNEGGESVLVVQL-EVLEMLRRPTFRNPFN----EKIVAQLGKSTALNCSVDGNP 2365
Query: 391 TPALRW-TKDSTPLGDGPM-----------LSLSSITFDSNGTYVCEAS-----LPTVPV 433
P + W + T +GP +S T + G Y C A + + +
Sbjct: 2366 PPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVI 2425
Query: 434 LSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPA 493
L Q +L +K G+ ++L C + G P P + W+ G
Sbjct: 2426 LEIGQKPVILTYAPGTVKGI-----------SGESLSLHCVSDGIPKPNIKWTMPSGYVV 2474
Query: 494 EPIPGRQGWV---SSSLTLKVTSALSRDGISCEASNPHGN 530
+ ++ + +L +K +A R C+A N G+
Sbjct: 2475 DRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGH 2514
Score = 61.2 bits (147), Expect = 3e-09
Identities = 92/397 (23%), Positives = 152/397 (38%), Gaps = 77/397 (19%)
Query: 177 GNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFH 236
GNP P I W R L++ SR +G LS+ R+ DR +
Sbjct: 1674 GNPLPTIHWTRVPSGLDLSKRKQ-----NSRVQVLPNGTLSIQ-----RVEIQDR-GQYL 1722
Query: 237 CAAHYSLPEGRHGRLDSPTFHLTLH---YPTEHVQFWVGSPSTPAGWVREGDTVQLLCRG 293
C+A + H+TL YP ++ T V G TV+L CR
Sbjct: 1723 CSAS--------NLFGTDHLHVTLSVVSYPPRILE-----RRTKEITVHSGSTVELKCRA 1769
Query: 294 DGSPSP-------EYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAAD 346
+G PSP T+ + V ++G L L ++ G Y C + D
Sbjct: 1770 EGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQD 1829
Query: 347 DVQLSKTLELRVAYLDPLELSEGK-VLSLPLNSSAVVNCSVHGLPTPALRW--------- 396
S ++++V P+ L + + V+ S + C+ G P P++ W
Sbjct: 1830 ----SLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVK 1885
Query: 397 ----TKDSTPLGDGPMLSLSSITFDSNGTYVCEASLPT-----VPVLSRTQNFTLLVQGS 447
T L L + ++ GTY C A+ T V +L+ + T S
Sbjct: 1886 PLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT-----S 1940
Query: 448 PELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSL 507
P ++ A + + + ++ GD++ L CSA G P P++ W P++ + +Q V S +
Sbjct: 1941 PRIEAAS-QKRTEVNF--GDKLLLNCSATGEPKPQIMWR----LPSKAVVDQQHRVGSWI 1993
Query: 508 ------TLKVTSALSRDG--ISCEASNPHGNKRHVFH 536
+L + S +D C A N G+ + H
Sbjct: 1994 HVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMH 2030
Score = 58.5 bits (140), Expect = 2e-08
Identities = 109/465 (23%), Positives = 171/465 (36%), Gaps = 77/465 (16%)
Query: 102 YQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTL-- 159
Y + G L + + ++ D +YVCV R +G +L+V +KP T+
Sbjct: 2190 YTFHANGSLTINKVKLLDSGEYVCVAR-NPSGDDTKMYKLDVVSKPPLINGLYTNRTVIK 2248
Query: 160 SVMEDSAQEIATCNSRNGNPAPKITWYR-NGQRLEVPVEMNPEGYMTSRTVREASGLLSL 218
+ +++ C + G P+P++ W + L P Y SR +G L +
Sbjct: 2249 ATAVRHSKKHFDCRAE-GTPSPEVMWIMPDNIFLTAP-------YYGSRITVHKNGTLEI 2300
Query: 219 TSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLT-LHYPTEHVQFWVGSPSTP 277
+ +R D A F C A EG L L L PT +P
Sbjct: 2301 RN-----VRLSD-SADFICVARN---EGGESVLVVQLEVLEMLRRPTFR------NPFNE 2345
Query: 278 AGWVREGDTVQLLCRGDGSPSPEY-------TLFRLQDEQEEVLNVNLEGNLTLEGVTRG 330
+ G + L C DG+P PE T F + + L + G+ + TR
Sbjct: 2346 KIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYL-IASNGSFIISKTTRE 2404
Query: 331 QSGTYGCRVEDYDAADDVQLSKTLELRVAYLDP-LELSEGKVLSLPLNSSAVVNCSVHGL 389
+G Y C + + K + L + L + G V + S ++C G+
Sbjct: 2405 DAGKYRCAARNKVG----YIEKLVILEIGQKPVILTYAPGTVKGIS-GESLSLHCVSDGI 2459
Query: 390 PTPALRWTKDSTPLGDGPMLSLSSITFDS------------NGTYVCEA------SLPTV 431
P P ++WT S + D P ++ I D+ G Y+C+A +L TV
Sbjct: 2460 PKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITV 2519
Query: 432 PVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGS 491
PV ++V P + P R G L C A G P P+++W S
Sbjct: 2520 PV--------MIVAYPPRITN---RPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHS 2568
Query: 492 PAEPIPGRQGWVSSSLTLKVTSAL-----SRDGI-SCEASNPHGN 530
+ S L L+ T + S GI C A NP G+
Sbjct: 2569 LLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
Score = 47.8 bits (112), Expect = 3e-05
Identities = 52/180 (28%), Positives = 69/180 (38%), Gaps = 34/180 (18%)
Query: 373 SLPLNSSAVVNCSVHGLPTPALRWTKDSTPLG-------------DGPMLSLSSITFDSN 419
++P NS A + C G P P + WT+ + L LS+ +
Sbjct: 1659 TIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDR 1718
Query: 420 GTYVCEASLPTVPVLSRTQNF--TLLVQGSP----ELKTAEIEPKADGSWREGDEVTLIC 473
G Y+C AS L T + TL V P E +T EI + G V L C
Sbjct: 1719 GQYLCSAS-----NLFGTDHLHVTLSVVSYPPRILERRTKEI------TVHSGSTVELKC 1767
Query: 474 SARGHPDPKLSWSQLGGS-PAEPIPG-RQG--WVSSSLTLKVTSALSRDGISCEASNPHG 529
A G P P ++W + +E G RQ V +L L S R C ASNP G
Sbjct: 1768 RAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGG 1827
Score = 39.7 bits (91), Expect = 0.008
Identities = 41/170 (24%), Positives = 71/170 (41%), Gaps = 31/170 (18%)
Query: 284 GDTVQLLCRGDGSPSPEYTLFRLQD---------EQEEVLNVNLEGNLTLEGVTRGQSGT 334
G TV L C G G P+P + + L D ++ + ++ G L L+ +G
Sbjct: 490 GGTVGLNCPGQGDPTP-HVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGV 548
Query: 335 YGCRVEDYDAADDVQLSKTLELRVAYLDPL-----------ELSEGKVLSLPLNSSAVVN 383
Y C +YD AD L R+ ++PL + G+ L LP +S+ + +
Sbjct: 549 YHCISSNYDDAD------ILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
Query: 384 CSVHGL---PTPALRWTKDSTPLGDGPMLSLSSITFDSNGTYVCEASLPT 430
S+ + + ++D L +G L + +T G Y C A+ P+
Sbjct: 603 ASISWVIPGNNVLYQSSRDKKVLNNG-TLRILQVTPKDQGYYRCVAANPS 651
Score = 36.6 bits (83), Expect = 0.066
Identities = 52/255 (20%), Positives = 85/255 (33%), Gaps = 40/255 (15%)
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
+S Y + S G ++++ D Y C R G E L + KP +P
Sbjct: 2384 QSYQYLIASNGSFIISKTTREDAGKYRCAAR-NKVGYIEKLVILEIGQKPVILTYAPG-- 2440
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
+V S + ++ +G P P I W P GY+ R +L
Sbjct: 2441 --TVKGISGESLSLHCVSDGIPKPNIKWTM------------PSGYVVDRPQINGKYILH 2486
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
TL ++ ++ C A S+ H + P V + + P
Sbjct: 2487 DNGTLVIKEATAYDRGNYICKAQNSVG------------HTLITVPVMIVAYPPRITNRP 2534
Query: 278 AGWV--REGDTVQLLCRGDGSPSPEYT---------LFRLQDEQEEVLNVNLEGNLTLEG 326
+ R G QL C G P PE T ++ ++L+G L ++
Sbjct: 2535 PRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQN 2594
Query: 327 VTRGQSGTYGCRVED 341
SG Y C ++
Sbjct: 2595 PQTSDSGIYKCTAKN 2609
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 72.8 bits (177), Expect = 8e-13
Identities = 93/383 (24%), Positives = 149/383 (38%), Gaps = 66/383 (17%)
Query: 177 GNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFH 236
G P +ITW +NG L PE ++ + A+G L + + +
Sbjct: 67 GTPPVRITWRKNGVEL-------PE---STHSTLLANGSLMIRHFRLEPGGSPSDEGDYE 116
Query: 237 CAAH--YSLPEGRHGRLDSPT---FHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLC 291
C A + L R R+ + T FH+ H Q VG EG + C
Sbjct: 117 CVAQNRFGLVVSRKARIQAATMSDFHV-------HPQATVGE---------EGGVARFQC 160
Query: 292 RGDGSPSPEYTLFRLQ---DEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDV 348
+ G P P T + + D E + +G L + G+ G + C + + +
Sbjct: 161 QIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIAS---I 217
Query: 349 QLSKTLELRV------AYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK-DST 401
++S L V AY +P L + L+L ++ +AV+ C G P P + W++ D
Sbjct: 218 RISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGR 277
Query: 402 PLGDGPM-------LSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAE 454
P+G + L +S +T +G YVC A+ P V RT L+VQ E
Sbjct: 278 PIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRV-RRTAQGRLVVQAPAEF---- 332
Query: 455 IEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWV-----SSSLTL 509
++ S G C A+G P P ++W + G + G G V +S+LT+
Sbjct: 333 VQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNG-----QVLGPGGHVRLKNNNSTLTI 387
Query: 510 KVTSALSRDGISCEASNPHGNKR 532
C A N G+ +
Sbjct: 388 SGIGPEDEAIYQCVAENSAGSSQ 410
Score = 65.9 bits (159), Expect = 1e-10
Identities = 109/438 (24%), Positives = 167/438 (38%), Gaps = 78/438 (17%)
Query: 14 PRLLL--LAVLLAAHPDA---QAEVRLSVPPLVEV-MRGKSVILDCTPTGTHDHYMLEWF 67
PRLLL L +LL A + AE+ +V P +V + G+ ++LDC GT
Sbjct: 18 PRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTP-------- 69
Query: 68 LTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQV------GDER 121
P + G EL + H T L + G L++ ++ DE
Sbjct: 70 --------PVRITWRKNGVELPESTHST--------LLANGSLMIRHFRLEPGGSPSDEG 113
Query: 122 DYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAP 181
DY CV + AR+ A V P +V E+ C +G P P
Sbjct: 114 DYECVAQNRFGLVVSRKARIQA-ATMSDFHVHPQA---TVGEEGGVARFQCQI-HGLPKP 168
Query: 182 KITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHC-AAH 240
ITW +N VP++ + E Y G+L +T LR +D FHC A++
Sbjct: 169 LITWEKN----RVPIDTDNERYTLL-----PKGVLQITG-----LRAED-GGIFHCVASN 213
Query: 241 YSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPE 300
+ HG + + + Y + + P V + T L C G+P P
Sbjct: 214 IASIRISHGARLTVSGSGSGAYKEPAI---LVGPENLTLTVHQ--TAVLECVATGNPRPI 268
Query: 301 YTLFRLQDEQEEVLNVNL--EGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRV 358
+ RL V + + GNL + VT SG Y C ++ +T + R+
Sbjct: 269 VSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAAN----RPGTRVRRTAQGRL 324
Query: 359 AYLDPLE-LSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDG---------PM 408
P E + + +S P ++A+ C G P P + W K+ LG G
Sbjct: 325 VVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNST 384
Query: 409 LSLSSITFDSNGTYVCEA 426
L++S I + Y C A
Sbjct: 385 LTISGIGPEDEAIYQCVA 402
Score = 51.2 bits (121), Expect = 3e-06
Identities = 64/290 (22%), Positives = 107/290 (36%), Gaps = 33/290 (11%)
Query: 284 GDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTL--------EGVTRGQSGTY 335
G + L CR +G+P T + E E + L N +L G + G Y
Sbjct: 56 GQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDY 115
Query: 336 GCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALR 395
C ++ + +S+ ++ A + + + A C +HGLP P +
Sbjct: 116 ECVAQNRFG---LVVSRKARIQAATMSDFHVHPQATVGEE-GGVARFQCQIHGLPKPLIT 171
Query: 396 WTKDSTPLGDG---------PMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQG 446
W K+ P+ +L ++ + + G + C AS +S T+ G
Sbjct: 172 WEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSG 231
Query: 447 SPELKTAEIEPKADG-SWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSS 505
S K I + + L C A G+P P +SWS+L G P + G Q +
Sbjct: 232 SGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI-GVEGIQVLGTG 290
Query: 506 SLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVA 555
+L + + C A+ P GT +T+Q + V A A
Sbjct: 291 NLIISDVTVQHSGVYVCAANRP----------GTRVRRTAQGRLVVQAPA 330
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 72.8 bits (177), Expect = 8e-13
Identities = 99/412 (24%), Positives = 157/412 (38%), Gaps = 61/412 (14%)
Query: 99 SPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGT 158
S YQ+ G L++ +AQ D +Y C+VR +AG T ++V +P +PN T
Sbjct: 2392 SEKYQIYQDGTLLIQKAQRSDSGNYTCLVR-NSAGEDRKTVWIHVNVQPPKINGNPNPIT 2450
Query: 159 L--SVMEDSAQEIATCNSRNGNPAPKITW-YRNGQRLEVPVEMNPEGYMTSRTVREASGL 215
+ ++++ C + G P P++ W + G L P Y +R +G
Sbjct: 2451 TVREIAAGGSRKLIDCKA-EGIPTPRVLWAFPEGVVLPAP-------YYGNRITVHGNGS 2502
Query: 216 LSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPS 275
L + S LRK D C A EG RL LT+ P E F P
Sbjct: 2503 LDIRS-----LRKSD-SVQLVCMAR---NEGGEARL---ILQLTVLEPMEKPIF--HDPI 2548
Query: 276 TPAGWVREGDTVQLLCRGDGSPSPEYTLF-----RLQDEQE-EVLNVNLEGNLTLEGVTR 329
+ G T+ L C G+P+P LQ Q+ + +G L + G++
Sbjct: 2549 SEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSS 2608
Query: 330 GQSGTYGCRVEDYDAADDVQLSKTL----ELRVAYLDPLELSEGKVLSLPLNSSAVVNCS 385
+G Y C + + +S + E Y + + + G+ L LP C+
Sbjct: 2609 VDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLP--------CT 2660
Query: 386 VHGLPTPALRWTKDSTPLGDGPM------------LSLSSITFDSNGTYVCEASLPTVPV 433
G WT + +GP L++ + GTYVC P
Sbjct: 2661 PPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPS 2720
Query: 434 LSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSW 485
++ + ++V P T+E P R G+ V L C A G P ++W
Sbjct: 2721 VT---SIPVIVIAYPPRITSEPTPVI--YTRPGNTVKLNCMAMGIPKADITW 2767
Score = 70.1 bits (170), Expect = 5e-12
Identities = 105/473 (22%), Positives = 172/473 (36%), Gaps = 80/473 (16%)
Query: 41 VEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSP 100
V V G ++ ++C GT + W DR R + ++G ++T+H+ R
Sbjct: 1960 VTVYLGDTIAMECLAKGTPAP-QISWIFPDR---RVWQTVSPVEG---RITLHENR---- 2008
Query: 101 PYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLS 160
L + EA D Y CV + AAG RL+V A P V + +
Sbjct: 2009 --------TLSIKEASFSDRGVYKCVA-SNAAGADSLAIRLHVAALPP---VIHQEKLEN 2056
Query: 161 VMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTS 220
+ I + P P + W L ++ P ++ +G
Sbjct: 2057 ISLPPGLSIHIHCTAKAAPLPSVRWV-----LGDGTQIRPSQFLHGNLFVFPNG------ 2105
Query: 221 TLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGW 280
TLY+R + C A + R T L + + + SP
Sbjct: 2106 TLYIRNLAPKDSGRYECVAANLVGSARR------TVQLNVQRAAANARITGTSPRRTD-- 2157
Query: 281 VREGDTVQLLCRGDGSPSPEYTLFRLQDEQ--------EEVLNVNLEGNLTLEGVTRGQS 332
VR G T++L C G P P L+RL ++ + + V G L ++ VT +
Sbjct: 2158 VRYGGTLKLDCSASGDPWPRI-LWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDA 2216
Query: 333 GTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTP 392
G Y C + D V L + ++ A ++ E ++ KV V+C GLP P
Sbjct: 2217 GDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVF---YGGDLKVDCVATGLPNP 2273
Query: 393 ALRWTKDSTPLGDGPMLSLSS-------ITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQ 445
+ W+ L + M S S + F++ Y E + ++T +
Sbjct: 2274 EISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGM------REEGDYTCFAE 2327
Query: 446 ---GSPELKTAEIEPKADGSWRE----------GDEVTLICSARGHPDPKLSW 485
G E++ A + R GD VT+ C A+G P PK++W
Sbjct: 2328 NQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTW 2380
Score = 50.8 bits (120), Expect = 3e-06
Identities = 90/409 (22%), Positives = 153/409 (37%), Gaps = 49/409 (11%)
Query: 102 YQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSV 161
+++ G LV+ + QV D Y+C + G L+V + S +
Sbjct: 1905 FEVLKNGTLVIRKVQVQDRGQYMCTA-SNLHGLDRMVVLLSVTVQQPQILASHYQDVTVY 1963
Query: 162 MEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTST 221
+ D+ IA G PAP+I+W +R+ +TV G ++L
Sbjct: 1964 LGDT---IAMECLAKGTPAPQISWIFPDRRVW-------------QTVSPVEGRITLHEN 2007
Query: 222 LYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTF--HLTLHYPTEHVQFWVGSPSTPAG 279
L ++ +ASF Y DS H+ P H Q + + S P G
Sbjct: 2008 RTLSIK----EASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIH-QEKLENISLPPG 2062
Query: 280 WVREGDTVQLLCRGDGSPSPEYTLFR---LQDEQEEVLNVNL----EGNLTLEGVTRGQS 332
++ + C +P P Q + L+ NL G L + + S
Sbjct: 2063 L-----SIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDS 2117
Query: 333 GTYGCRVEDY--DAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLP 390
G Y C + A VQL+ R A + + + + + ++CS G P
Sbjct: 2118 GRYECVAANLVGSARRTVQLNVQ---RAAANARITGTSPRRTDVRYGGTLKLDCSASGDP 2174
Query: 391 TPALRWTKDSTPLGDGPMLSLSSITFDSNGTYVC------EASLPTVPVLSRTQNFTLLV 444
P + W S + D S I +NGT V +A ++ + +++
Sbjct: 2175 WPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVL 2234
Query: 445 QGSPELKTAEIEPKADGSWRE--GDEVTLICSARGHPDPKLSWSQLGGS 491
+ +K A+IE K + + G ++ + C A G P+P++SWS GS
Sbjct: 2235 KVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGS 2283
Score = 47.8 bits (112), Expect = 3e-05
Identities = 82/360 (22%), Positives = 133/360 (36%), Gaps = 70/360 (19%)
Query: 12 GAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDR 71
G RL+L +L P + + + M G ++ L+C+ GT ++ W L +
Sbjct: 2525 GEARLILQLTVL--EPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLV-WVLPNG 2581
Query: 72 SGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGA 131
+ + G +LQ H + G L ++ D Y CV R A
Sbjct: 2582 TDLQ--------SGQQLQRFYHK-----------ADGMLHISGLSSVDAGAYRCVAR-NA 2621
Query: 132 AGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITW-YRNGQ 190
AG E L V KPEA + N +S++ ++ G + +W NG
Sbjct: 2622 AGHTERLVSLKVGLKPEANKQYHN--LVSIINGETLKLPCTPPGAGQG--RFSWTLPNGM 2677
Query: 191 RLEVPVEMNPEGYMTSRT--VREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRH 248
LE P + + + T VREAS F + E +
Sbjct: 2678 HLEGPQTLGRVSLLDNGTLTVREAS--------------------VFDRGTYVCRMETEY 2717
Query: 249 GRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQD 308
G + + + YP + S TP + R G+TV+L C G P + T + L D
Sbjct: 2718 GPSVTSIPVIVIAYPPR-----ITSEPTPVIYTRPGNTVKLNCMAMGIPKADIT-WELPD 2771
Query: 309 EQEEVLNVNL----------EGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRV 358
+ V +G+LT++ T+ +G Y C ++ +D SKT + V
Sbjct: 2772 KSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSD----SKTTYIHV 2827
Score = 45.1 bits (105), Expect = 2e-04
Identities = 43/177 (24%), Positives = 69/177 (38%), Gaps = 22/177 (12%)
Query: 370 KVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGP-------------MLSLSSITF 416
+ +S+ + V C G P P + WTK ST P L + +
Sbjct: 1861 QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQV 1920
Query: 417 DSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSAR 476
G Y+C AS + L R + P++ + + D + GD + + C A+
Sbjct: 1921 QDRGQYMCTAS--NLHGLDRMVVLLSVTVQQPQILASHYQ---DVTVYLGDTIAMECLAK 1975
Query: 477 GHPDPKLSW---SQLGGSPAEPIPGR-QGWVSSSLTLKVTSALSRDGISCEASNPHG 529
G P P++SW + P+ GR + +L++K S R C ASN G
Sbjct: 1976 GTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAG 2032
Score = 44.7 bits (104), Expect = 2e-04
Identities = 107/480 (22%), Positives = 164/480 (34%), Gaps = 91/480 (18%)
Query: 108 GRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNV---FAKPEATEVSPNK------GT 158
G L + D Y CV A G+A T +LNV A T SP + GT
Sbjct: 2105 GTLYIRNLAPKDSGRYECVA-ANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGT 2163
Query: 159 LSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSL 218
L + C S +G+P P+I W +R+ ++ SR A+G L +
Sbjct: 2164 LKL---------DC-SASGDPWPRILWRLPSKRM-----IDALFSFDSRIKVFANGTLVV 2208
Query: 219 TSTLYLRLRKDDRDAS-FHCAAHYSLPEGRHG-RLDSPTFHLTLHYPTE--HVQFW---- 270
S D+DA + C A + + ++D + + E H F+
Sbjct: 2209 KSVT-------DKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDL 2261
Query: 271 ------VGSPSTPAGW-VREGDTVQLLCRGD--GSPSPEYTLFRLQDEQEEVLNVNLEGN 321
G P+ W + +G V + D G + Y +F G
Sbjct: 2262 KVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFN-------------NGT 2308
Query: 322 LTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAV 381
L V + G Y C E+ D++++ + A + + +P
Sbjct: 2309 LYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPA---TIRNKTYLAVQVPYGDVVT 2365
Query: 382 VNCSVHGLPTPALRWTKDSTPL-----------GDGPMLSLSSITFDSNGTYVC----EA 426
V C G P P + W + + DG +L + DS G Y C A
Sbjct: 2366 VACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDS-GNYTCLVRNSA 2424
Query: 427 SLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWS 486
V + G+P T E A GS + D C A G P P++ W+
Sbjct: 2425 GEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLID-----CKAEGIPTPRVLWA 2479
Query: 487 QLGG--SPAEPIPGRQGWVSSSLTLKVTSALSRDGIS--CEASNPHGNKRHVFHFGTVSP 542
G PA P G + V + +L + S D + C A N G R + + P
Sbjct: 2480 FPEGVVLPA-PYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEP 2538
Score = 32.3 bits (72), Expect = 1.2
Identities = 30/118 (25%), Positives = 48/118 (40%), Gaps = 19/118 (16%)
Query: 382 VNCSVHGLPTPALRWTKDSTPLGDGPM--------------LSLSSITFDSNGTYVCEAS 427
++C+V +P++ W + PM L + S+ +G Y C A
Sbjct: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQ 558
Query: 428 LPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSW 485
+ + +LVQ SP + AE + G G+ VTL C+A P+ LSW
Sbjct: 559 VRDE---MDRMVYRVLVQ-SPSTQPAEKDTVTIGK-NPGESVTLPCNALAIPEAHLSW 611
Score = 30.4 bits (67), Expect = 4.7
Identities = 31/139 (22%), Positives = 53/139 (38%), Gaps = 31/139 (22%)
Query: 427 SLPTVPVLSRTQN----FTLLVQGSPELKTAEIE-----PKADGSWREGDEVTLI----- 472
+L +P++S TQ+ T VQ S + + P A W G++ ++
Sbjct: 1802 NLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQ 1861
Query: 473 -------------CSARGHPDPKLSWSQLGG----SPAEPIPGRQGWVSSSLTLKVTSAL 515
C A G P P ++W+++ +P I + + +L ++
Sbjct: 1862 TVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQ 1921
Query: 516 SRDGISCEASNPHGNKRHV 534
R C ASN HG R V
Sbjct: 1922 DRGQYMCTASNLHGLDRMV 1940
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 70.1 bits (170), Expect = 5e-12
Identities = 90/375 (24%), Positives = 145/375 (38%), Gaps = 72/375 (19%)
Query: 38 PPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRG 97
P V V G+ +L+C P H + W R A ++ E ++T+ RG
Sbjct: 172 PGNVVVAVGEPAVLECVPPRGHPEPSVSW----------RKDGARLKEEEGRITI---RG 218
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
G+L+++ D YVCV A A A + V +P N+
Sbjct: 219 ----------GKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQV 268
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
L+ A C + G+P P++ W + L P G R+
Sbjct: 269 VLA----DAPVTFLCEVK-GDPPPRLRWRKEDGEL-------PTGRYEIRS--------- 307
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
+L++ + + ++ C A S+ GR ++ + L++H P + V + P
Sbjct: 308 -DHSLWIGHVSAEDEGTYTCVAENSV-----GRAEA-SGSLSVHVPPQLVTQPQDQMAAP 360
Query: 278 AGWVREGDTVQLLCRGDGSPSP---------EYTLFRLQDEQEEV-LNVNLEGNLTLEGV 327
G++V C G+P P + LF Q Q +V+ G L + V
Sbjct: 361 ------GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAV 414
Query: 328 TRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLD---PLELSEGKVLSLPLNSSAVVNC 384
RG +G Y C+ A + LE++ A LD P+ L +L L SS + C
Sbjct: 415 QRGDAGYYVCQA--VSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPC 472
Query: 385 SVHGLPTPALRWTKD 399
V G P P++RW KD
Sbjct: 473 RVTGNPQPSVRWKKD 487
Score = 68.9 bits (167), Expect = 1e-11
Identities = 107/480 (22%), Positives = 174/480 (36%), Gaps = 89/480 (18%)
Query: 38 PPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRG 97
PP + V RG+ L C G +EW+ ++GAR + + L +
Sbjct: 70 PPDLLVSRGEPATLPCRAEG-RPRPNIEWY---KNGARVATVREDPRAHRLLL------- 118
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
P R+V DE Y CV R A A L V + SP
Sbjct: 119 ---PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNV 175
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
++V E + E C G+P P ++W ++G RL+ EG +T R G L
Sbjct: 176 VVAVGEPAVLE---CVPPRGHPEPSVSWRKDGARLK-----EEEGRITIR-----GGKLM 222
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGR------LDSPTFHLTLHYPTEHVQFWV 271
++ TL DA + ++ R L+ P+F L P V
Sbjct: 223 MSHTL-------KSDAGMYVCVASNMAGERESAAAEVMVLERPSF---LRRPVNQV---- 268
Query: 272 GSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEV----LNVNLEGNLTLEGV 327
V V LC G P P R + E E+ + + +L + V
Sbjct: 269 ---------VLADAPVTFLCEVKGDPPPR---LRWRKEDGELPTGRYEIRSDHSLWIGHV 316
Query: 328 TRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVH 387
+ GTY C E+ + + S +L + V P +++ + S C
Sbjct: 317 SAEDEGTYTCVAEN--SVGRAEASGSLSVHVP---PQLVTQPQDQMAAPGESVAFQCETK 371
Query: 388 GLPTPALRWTKDSTPLGDGP----------------MLSLSSITFDSNGTYVCEASLPTV 431
G P PA+ W K+ + + P L+++++ G YVC+A
Sbjct: 372 GNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAG 431
Query: 432 PVLSRTQNFTLLVQGSP--ELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
+L++ L ++G+ L ++ A+ + G V L C G+P P + W + G
Sbjct: 432 SILAKA---LLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDG 488
Score = 52.0 bits (123), Expect = 2e-06
Identities = 71/273 (26%), Positives = 101/273 (36%), Gaps = 38/273 (13%)
Query: 281 VREGDTVQLLCRGDGSPSPEYTLF----RLQDEQEEVLNVNL---EGNLTLEGVTRGQ-- 331
V G+ L CR +G P P + R+ +E+ L G L + G+
Sbjct: 75 VSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRA 134
Query: 332 ---SGTYGCRVEDYDAADDVQLSKTLELRVAYL-DPLELSEGKVLSLPLNSSAVVNC-SV 386
G Y C +Y A S+ L VA L D S G V+ + + AV+ C
Sbjct: 135 RPDEGVYTCVARNYLGA---AASRNASLEVAVLRDDFRQSPGNVV-VAVGEPAVLECVPP 190
Query: 387 HGLPTPALRWTKDSTPLGD--------GPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQ 438
G P P++ W KD L + G L +S G YVC AS S
Sbjct: 191 RGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAA 250
Query: 439 NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPG 498
+L + S + AD VT +C +G P P+L W + G +P
Sbjct: 251 EVMVLERPSFLRRPVNQVVLADAP------VTFLCEVKGDPPPRLRWRKEDGE----LPT 300
Query: 499 RQGWVSS--SLTLKVTSALSRDGISCEASNPHG 529
+ + S SL + SA +C A N G
Sbjct: 301 GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVG 333
Score = 32.7 bits (73), Expect = 0.96
Identities = 20/65 (30%), Positives = 26/65 (40%), Gaps = 10/65 (15%)
Query: 439 NFTLLVQGSPELKTAEIEPK----------ADGSWREGDEVTLICSARGHPDPKLSWSQL 488
N TLL G P L + + P+ D G+ TL C A G P P + W +
Sbjct: 41 NHTLLPPGDPSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKN 100
Query: 489 GGSPA 493
G A
Sbjct: 101 GARVA 105
Score = 32.3 bits (72), Expect = 1.2
Identities = 30/134 (22%), Positives = 55/134 (41%), Gaps = 14/134 (10%)
Query: 67 FLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCV 126
F + G P + +GS++ + + + + + +G+L + Q GD YVC
Sbjct: 366 FQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQ 425
Query: 127 VRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSR-------NGNP 179
AG+ A A L + K + + P +++ A + S GNP
Sbjct: 426 A-VSVAGSILAKALLEI--KGASLDGLPPV----ILQGPANQTLVLGSSVWLPCRVTGNP 478
Query: 180 APKITWYRNGQRLE 193
P + W ++GQ L+
Sbjct: 479 QPSVRWKKDGQWLQ 492
>gi|21686977 cell adhesion molecule 4 [Homo sapiens]
Length = 388
Score = 68.6 bits (166), Expect = 2e-11
Identities = 87/321 (27%), Positives = 137/321 (42%), Gaps = 44/321 (13%)
Query: 281 VREGDTVQLLCR---GDGS------PSPEYTLFR----LQDEQEEVLNVNLEG-NLTLEG 326
V EG ++ CR DGS P+ + F L+DE+ ++ + + L
Sbjct: 34 VAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSD 93
Query: 327 VTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPL-ELSEGKVLSLPLNSSAVVNCS 385
G Y C++ D + TL + VA +P+ E+ E V + S +V S
Sbjct: 94 ARLEDEGGYFCQLYTEDTHHQIA---TLTVLVAPENPVVEVREQAVEGGEVELSCLVPRS 150
Query: 386 VHGLPTPALRWTKD-------STPLGDGPMLSLSS-ITF-----DSNGTYVCEASLPTVP 432
P LRW +D S+ +G + S++S + F D G +CEA +P
Sbjct: 151 ---RPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALP 207
Query: 433 V-LSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDP-KLSWSQLGG 490
S+ + L VQ SP TA I + REGD + L C+ G+P P ++ W++
Sbjct: 208 SGHSKQTQYVLDVQYSP---TARIHA-SQAVVREGDTLVLTCAVTGNPRPNQIRWNRGN- 262
Query: 491 SPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVA 550
E +P R V +LTL + +CEASN HG+ R ++ P
Sbjct: 263 ---ESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQT 319
Query: 551 VMAVAVSVGLLLLVVAVFYCV 571
+ A+ G+L L+V + CV
Sbjct: 320 SVPYAIVGGILALLVFLIICV 340
Score = 57.0 bits (136), Expect = 5e-08
Identities = 63/235 (26%), Positives = 97/235 (41%), Gaps = 29/235 (12%)
Query: 109 RLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQE 168
R+ L++A++ DE Y C + T A L V PE V + +E E
Sbjct: 88 RIRLSDARLEDEGGYFCQLYT--EDTHHQIATLTVLVAPENPVVEVRE---QAVEGGEVE 142
Query: 169 IATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRL-R 227
++ C PA + WYR+ + L +G +S +E + S+ ST+ R+ R
Sbjct: 143 LS-CLVPRSRPAATLRWYRDRKEL--------KGVSSS---QENGKVWSVASTVRFRVDR 190
Query: 228 KDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHY-PTEHVQFWVGSPSTPAGWVREGDT 286
KDD A + +LP G H + + L + Y PT + VREGDT
Sbjct: 191 KDDGGIIICEAQNQALPSG-HSK--QTQYVLDVQYSPTARIH-------ASQAVVREGDT 240
Query: 287 VQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVED 341
+ L C G+P P + +E + LTL G+ +GTY C +
Sbjct: 241 LVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASN 295
>gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Homo
sapiens]
Length = 698
Score = 68.2 bits (165), Expect = 2e-11
Identities = 152/640 (23%), Positives = 233/640 (36%), Gaps = 105/640 (16%)
Query: 7 PAQARG-APRLLLLAVLL----AAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDH 61
P QA+ +P +LLL +LL A + L V V V G VI+ C + D
Sbjct: 3 PGQAQPQSPEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDG 62
Query: 62 YMLE------WFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQG-----RL 110
+ WF S + Q E++++ D +QL L
Sbjct: 63 WDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDR------FQLTGDPGKGSCSL 116
Query: 111 VLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIA 170
V+ +AQ DE Y V G+ + F K A P+ +E
Sbjct: 117 VIRDAQREDEAWYFFRVERGSRVRHSFLSNA-FFLKVTALTKKPDVYIPETLEPGQPVTV 175
Query: 171 TCNSR---NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLR 227
C PAP +W ++ R R ++ S+ S
Sbjct: 176 ICVFNWAFKKCPAPSFSW--------------TGAALSPRRTRPSTSHFSVLS---FTPS 218
Query: 228 KDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGW------- 280
D D C +S R G T L + Y + + + +T A
Sbjct: 219 PQDHDTDLTCHVDFS----RKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIY 274
Query: 281 --VREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGN-----LTLEGVTRGQSG 333
V++G ++LLC D P P + LQD VL+ + L L GV G SG
Sbjct: 275 LEVQKGQFLRLLCAADSQP-PATLSWVLQDR---VLSSSHPWGPRTLGLELRGVRAGDSG 330
Query: 334 TYGCRVEDYDAADDVQLSKTLE-----LRV----AYLDPLE-LSEGKVLSLPLNSSAVVN 383
Y CR E+ + L +++ LRV A LE L G L + S +
Sbjct: 331 RYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLV 390
Query: 384 CSVHGLPTPALRWTKDSTPLG-----DGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQ 438
C H P L WT+ +G D +L L I + G + C A P+ S+
Sbjct: 391 CVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQ---HPLGSQHV 447
Query: 439 NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSW----SQLGGSPA- 493
+ +L V P+L + P SW E + + CS++ P P L W L G+ +
Sbjct: 448 SLSLSVHYPPQL----LGPSC--SW-EAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQ 500
Query: 494 ---EPIPGRQG-WVSSSLTLK--VTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQA 547
E P G W +SSL+L ++S L + C+A N HG + F + +
Sbjct: 501 GSFEVTPSSAGPWANSSLSLHGGLSSGLR---LRCKAWNVHGAQSGSV-FQLLPGKLEHG 556
Query: 548 GVAVMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGA 587
G + A+ G+ L+ V + C ++ R++ A
Sbjct: 557 GGLGLGAALGAGVAALLAFCSCLVVFRVKICRKEARKRAA 596
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 65.9 bits (159), Expect = 1e-10
Identities = 83/340 (24%), Positives = 128/340 (37%), Gaps = 43/340 (12%)
Query: 165 SAQEIATCNSR-NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
S E AT N + G P P I WY+ G+R+E + +P + LL S +
Sbjct: 41 SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKD-DPRSHRM---------LLPSGSLFF 90
Query: 224 LRL---RKDDRDASFH-CAAHYSLPEG--RHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
LR+ RK D + C A L E + L+ V VG P+
Sbjct: 91 LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 278 AGWVREGDTVQLLC-RGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYG 336
G + + DGSP D+++E + + G L + + +G Y
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPL---------DDKDERITIR-GGKLMITYTRKSDAGKYV 200
Query: 337 CRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRW 396
C + + ++++ L P + L++ ++ SA C G P P +RW
Sbjct: 201 CVGTNMVGERESEVAELTVLE----RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 397 TKDSTPL-------GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPE 449
KD L D L + +T G+Y C A V + TL VQ E
Sbjct: 257 RKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAE---NMVGKAEASATLTVQVGSE 313
Query: 450 LKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
++P+ D G VT C A G+P P + W + G
Sbjct: 314 PPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Score = 60.8 bits (146), Expect = 3e-09
Identities = 93/415 (22%), Positives = 151/415 (36%), Gaps = 78/415 (18%)
Query: 38 PPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRG 97
P V V G+ +++C P H + W + + + + ++T+ RG
Sbjct: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISW----------KKDGSPLDDKDERITI---RG 183
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
G+L++ + D YVCV A L V +P + N
Sbjct: 184 ----------GKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSN-- 231
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
L+V D + E C +R G+P P + W ++ L P+ R
Sbjct: 232 -LAVTVDDSAEFK-CEAR-GDPVPTVRWRKDDGEL-------PKSRYEIRD--------- 272
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
TL +R S+ C A E G+ ++ LT+ +E F V P
Sbjct: 273 -DHTLKIRKVTAGDMGSYTCVA-----ENMVGKAEASAT-LTVQVGSEPPHFVV-KPRDQ 324
Query: 278 AGWVREGDTVQLLCRGDGSPSP---------EYTLFRLQDEQEEV-LNVNLEGNLTLEGV 327
V G TV C G+P P + LF Q Q +V+ G+LT+ V
Sbjct: 325 V--VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 382
Query: 328 TRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLD--PLELSEGKV-LSLPLNSSAVVNC 384
R G Y C+ + A + LE+ D P + +G V ++ ++ + V++C
Sbjct: 383 QRSDVGYYICQT--LNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 440
Query: 385 SVHGLPTPALRWTKDSTPLG---------DGPMLSLSSITFDSNGTYVCEASLPT 430
G P P + W KD + + +L + G Y C AS P+
Sbjct: 441 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Score = 57.8 bits (138), Expect = 3e-08
Identities = 92/406 (22%), Positives = 150/406 (36%), Gaps = 66/406 (16%)
Query: 109 RLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQE 168
R+V DE YVCV R A L V + +P+ ++V E + E
Sbjct: 92 RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151
Query: 169 IATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRK 228
C G+P P I+W ++G L+ E T+R G L +T T RK
Sbjct: 152 ---CQPPRGHPEPTISWKKDGSPLDDKDERI--------TIR--GGKLMITYT-----RK 193
Query: 229 DDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQ 288
D + C + G +S LT+ E F V PS A V D+ +
Sbjct: 194 SDA-GKYVCVGTNMV-----GERESEVAELTV---LERPSF-VKRPSNLA--VTVDDSAE 241
Query: 289 LLCRGDGSPSPEYTLFRLQDEQ--EEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAAD 346
C G P P +R D + + + + L + VT G G+Y C E+
Sbjct: 242 FKCEARGDPVPTVR-WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENM--VG 298
Query: 347 DVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDST----- 401
+ S TL ++V P + + + + L + C G P PA+ W ++ +
Sbjct: 299 KAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLF 358
Query: 402 -----------PLGDGPMLSLSSITFDSNGTYVCE-----ASLPTVPVLSRTQNFTLLVQ 445
+ L+++++ G Y+C+ S+ T L T + +
Sbjct: 359 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD--VIADR 416
Query: 446 GSPELKTAEIEP--KADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
P ++ + DG++ L C A G P P + W + G
Sbjct: 417 PPPVIRQGPVNQTVAVDGTF------VLSCVATGSPVPTILWRKDG 456
Score = 53.9 bits (128), Expect = 4e-07
Identities = 63/273 (23%), Positives = 105/273 (38%), Gaps = 38/273 (13%)
Query: 281 VREGDTVQLLCRGDGSPSPEYTLF----RLQDEQEEVLNVNL---EGNLTLEGVTRGQS- 332
V +G+ L C+ +G P+P + R++ ++++ + + G+L + G+
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 333 ----GTYGCRVEDYDAADDVQLSKTLELRVAYL-DPLELSEGKVLSLPLNSSAVVNCSV- 386
G Y C +Y +S L VA L D + V+ + + AV+ C
Sbjct: 100 RPDEGVYVCVARNYLGE---AVSHNASLEVAILRDDFRQNPSDVM-VAVGEPAVMECQPP 155
Query: 387 HGLPTPALRWTKDSTPLGD--------GPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQ 438
G P P + W KD +PL D G L ++ G YVC + S
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 439 NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPG 498
T+L + S + + + D D C ARG P P + W + G +P
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVD------DSAEFKCEARGDPVPTVRWRKDDGE----LPK 265
Query: 499 RQGWVSSSLTLKVTSALSRD--GISCEASNPHG 529
+ + TLK+ + D +C A N G
Sbjct: 266 SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 65.9 bits (159), Expect = 1e-10
Identities = 83/340 (24%), Positives = 128/340 (37%), Gaps = 43/340 (12%)
Query: 165 SAQEIATCNSR-NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
S E AT N + G P P I WY+ G+R+E + +P + LL S +
Sbjct: 41 SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKD-DPRSHRM---------LLPSGSLFF 90
Query: 224 LRL---RKDDRDASFH-CAAHYSLPEG--RHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
LR+ RK D + C A L E + L+ V VG P+
Sbjct: 91 LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 278 AGWVREGDTVQLLC-RGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYG 336
G + + DGSP D+++E + + G L + + +G Y
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPL---------DDKDERITIR-GGKLMITYTRKSDAGKYV 200
Query: 337 CRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRW 396
C + + ++++ L P + L++ ++ SA C G P P +RW
Sbjct: 201 CVGTNMVGERESEVAELTVLE----RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 397 TKDSTPL-------GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPE 449
KD L D L + +T G+Y C A V + TL VQ E
Sbjct: 257 RKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAE---NMVGKAEASATLTVQVGSE 313
Query: 450 LKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
++P+ D G VT C A G+P P + W + G
Sbjct: 314 PPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Score = 60.8 bits (146), Expect = 3e-09
Identities = 93/415 (22%), Positives = 151/415 (36%), Gaps = 78/415 (18%)
Query: 38 PPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRG 97
P V V G+ +++C P H + W + + + + ++T+ RG
Sbjct: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISW----------KKDGSPLDDKDERITI---RG 183
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
G+L++ + D YVCV A L V +P + N
Sbjct: 184 ----------GKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSN-- 231
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
L+V D + E C +R G+P P + W ++ L P+ R
Sbjct: 232 -LAVTVDDSAEFK-CEAR-GDPVPTVRWRKDDGEL-------PKSRYEIRD--------- 272
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
TL +R S+ C A E G+ ++ LT+ +E F V P
Sbjct: 273 -DHTLKIRKVTAGDMGSYTCVA-----ENMVGKAEASAT-LTVQVGSEPPHFVV-KPRDQ 324
Query: 278 AGWVREGDTVQLLCRGDGSPSP---------EYTLFRLQDEQEEV-LNVNLEGNLTLEGV 327
V G TV C G+P P + LF Q Q +V+ G+LT+ V
Sbjct: 325 V--VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 382
Query: 328 TRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLD--PLELSEGKV-LSLPLNSSAVVNC 384
R G Y C+ + A + LE+ D P + +G V ++ ++ + V++C
Sbjct: 383 QRSDVGYYICQT--LNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 440
Query: 385 SVHGLPTPALRWTKDSTPLG---------DGPMLSLSSITFDSNGTYVCEASLPT 430
G P P + W KD + + +L + G Y C AS P+
Sbjct: 441 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Score = 57.8 bits (138), Expect = 3e-08
Identities = 92/406 (22%), Positives = 150/406 (36%), Gaps = 66/406 (16%)
Query: 109 RLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQE 168
R+V DE YVCV R A L V + +P+ ++V E + E
Sbjct: 92 RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151
Query: 169 IATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRK 228
C G+P P I+W ++G L+ E T+R G L +T T RK
Sbjct: 152 ---CQPPRGHPEPTISWKKDGSPLDDKDERI--------TIR--GGKLMITYT-----RK 193
Query: 229 DDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQ 288
D + C + G +S LT+ E F V PS A V D+ +
Sbjct: 194 SDA-GKYVCVGTNMV-----GERESEVAELTV---LERPSF-VKRPSNLA--VTVDDSAE 241
Query: 289 LLCRGDGSPSPEYTLFRLQDEQ--EEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAAD 346
C G P P +R D + + + + L + VT G G+Y C E+
Sbjct: 242 FKCEARGDPVPTVR-WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENM--VG 298
Query: 347 DVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDST----- 401
+ S TL ++V P + + + + L + C G P PA+ W ++ +
Sbjct: 299 KAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLF 358
Query: 402 -----------PLGDGPMLSLSSITFDSNGTYVCE-----ASLPTVPVLSRTQNFTLLVQ 445
+ L+++++ G Y+C+ S+ T L T + +
Sbjct: 359 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD--VIADR 416
Query: 446 GSPELKTAEIEP--KADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
P ++ + DG++ L C A G P P + W + G
Sbjct: 417 PPPVIRQGPVNQTVAVDGTF------VLSCVATGSPVPTILWRKDG 456
Score = 53.9 bits (128), Expect = 4e-07
Identities = 63/273 (23%), Positives = 105/273 (38%), Gaps = 38/273 (13%)
Query: 281 VREGDTVQLLCRGDGSPSPEYTLF----RLQDEQEEVLNVNL---EGNLTLEGVTRGQS- 332
V +G+ L C+ +G P+P + R++ ++++ + + G+L + G+
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 333 ----GTYGCRVEDYDAADDVQLSKTLELRVAYL-DPLELSEGKVLSLPLNSSAVVNCSV- 386
G Y C +Y +S L VA L D + V+ + + AV+ C
Sbjct: 100 RPDEGVYVCVARNYLGE---AVSHNASLEVAILRDDFRQNPSDVM-VAVGEPAVMECQPP 155
Query: 387 HGLPTPALRWTKDSTPLGD--------GPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQ 438
G P P + W KD +PL D G L ++ G YVC + S
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 439 NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPG 498
T+L + S + + + D D C ARG P P + W + G +P
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVD------DSAEFKCEARGDPVPTVRWRKDDGE----LPK 265
Query: 499 RQGWVSSSLTLKVTSALSRD--GISCEASNPHG 529
+ + TLK+ + D +C A N G
Sbjct: 266 SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 65.9 bits (159), Expect = 1e-10
Identities = 83/340 (24%), Positives = 128/340 (37%), Gaps = 43/340 (12%)
Query: 165 SAQEIATCNSR-NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
S E AT N + G P P I WY+ G+R+E + +P + LL S +
Sbjct: 41 SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKD-DPRSHRM---------LLPSGSLFF 90
Query: 224 LRL---RKDDRDASFH-CAAHYSLPEG--RHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
LR+ RK D + C A L E + L+ V VG P+
Sbjct: 91 LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 278 AGWVREGDTVQLLC-RGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYG 336
G + + DGSP D+++E + + G L + + +G Y
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPL---------DDKDERITIR-GGKLMITYTRKSDAGKYV 200
Query: 337 CRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRW 396
C + + ++++ L P + L++ ++ SA C G P P +RW
Sbjct: 201 CVGTNMVGERESEVAELTVLE----RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 397 TKDSTPL-------GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPE 449
KD L D L + +T G+Y C A V + TL VQ E
Sbjct: 257 RKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAE---NMVGKAEASATLTVQVGSE 313
Query: 450 LKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
++P+ D G VT C A G+P P + W + G
Sbjct: 314 PPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Score = 60.8 bits (146), Expect = 3e-09
Identities = 93/415 (22%), Positives = 151/415 (36%), Gaps = 78/415 (18%)
Query: 38 PPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRG 97
P V V G+ +++C P H + W + + + + ++T+ RG
Sbjct: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISW----------KKDGSPLDDKDERITI---RG 183
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
G+L++ + D YVCV A L V +P + N
Sbjct: 184 ----------GKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSN-- 231
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
L+V D + E C +R G+P P + W ++ L P+ R
Sbjct: 232 -LAVTVDDSAEFK-CEAR-GDPVPTVRWRKDDGEL-------PKSRYEIRD--------- 272
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
TL +R S+ C A E G+ ++ LT+ +E F V P
Sbjct: 273 -DHTLKIRKVTAGDMGSYTCVA-----ENMVGKAEASAT-LTVQVGSEPPHFVV-KPRDQ 324
Query: 278 AGWVREGDTVQLLCRGDGSPSP---------EYTLFRLQDEQEEV-LNVNLEGNLTLEGV 327
V G TV C G+P P + LF Q Q +V+ G+LT+ V
Sbjct: 325 V--VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 382
Query: 328 TRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLD--PLELSEGKV-LSLPLNSSAVVNC 384
R G Y C+ + A + LE+ D P + +G V ++ ++ + V++C
Sbjct: 383 QRSDVGYYICQT--LNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 440
Query: 385 SVHGLPTPALRWTKDSTPLG---------DGPMLSLSSITFDSNGTYVCEASLPT 430
G P P + W KD + + +L + G Y C AS P+
Sbjct: 441 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Score = 57.8 bits (138), Expect = 3e-08
Identities = 92/406 (22%), Positives = 150/406 (36%), Gaps = 66/406 (16%)
Query: 109 RLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQE 168
R+V DE YVCV R A L V + +P+ ++V E + E
Sbjct: 92 RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151
Query: 169 IATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRK 228
C G+P P I+W ++G L+ E T+R G L +T T RK
Sbjct: 152 ---CQPPRGHPEPTISWKKDGSPLDDKDERI--------TIR--GGKLMITYT-----RK 193
Query: 229 DDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQ 288
D + C + G +S LT+ E F V PS A V D+ +
Sbjct: 194 SDA-GKYVCVGTNMV-----GERESEVAELTV---LERPSF-VKRPSNLA--VTVDDSAE 241
Query: 289 LLCRGDGSPSPEYTLFRLQDEQ--EEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAAD 346
C G P P +R D + + + + L + VT G G+Y C E+
Sbjct: 242 FKCEARGDPVPTVR-WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENM--VG 298
Query: 347 DVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDST----- 401
+ S TL ++V P + + + + L + C G P PA+ W ++ +
Sbjct: 299 KAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLF 358
Query: 402 -----------PLGDGPMLSLSSITFDSNGTYVCE-----ASLPTVPVLSRTQNFTLLVQ 445
+ L+++++ G Y+C+ S+ T L T + +
Sbjct: 359 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD--VIADR 416
Query: 446 GSPELKTAEIEP--KADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
P ++ + DG++ L C A G P P + W + G
Sbjct: 417 PPPVIRQGPVNQTVAVDGTF------VLSCVATGSPVPTILWRKDG 456
Score = 53.9 bits (128), Expect = 4e-07
Identities = 63/273 (23%), Positives = 105/273 (38%), Gaps = 38/273 (13%)
Query: 281 VREGDTVQLLCRGDGSPSPEYTLF----RLQDEQEEVLNVNL---EGNLTLEGVTRGQS- 332
V +G+ L C+ +G P+P + R++ ++++ + + G+L + G+
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 333 ----GTYGCRVEDYDAADDVQLSKTLELRVAYL-DPLELSEGKVLSLPLNSSAVVNCSV- 386
G Y C +Y +S L VA L D + V+ + + AV+ C
Sbjct: 100 RPDEGVYVCVARNYLGE---AVSHNASLEVAILRDDFRQNPSDVM-VAVGEPAVMECQPP 155
Query: 387 HGLPTPALRWTKDSTPLGD--------GPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQ 438
G P P + W KD +PL D G L ++ G YVC + S
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 439 NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPG 498
T+L + S + + + D D C ARG P P + W + G +P
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVD------DSAEFKCEARGDPVPTVRWRKDDGE----LPK 265
Query: 499 RQGWVSSSLTLKVTSALSRD--GISCEASNPHG 529
+ + TLK+ + D +C A N G
Sbjct: 266 SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 65.9 bits (159), Expect = 1e-10
Identities = 83/340 (24%), Positives = 128/340 (37%), Gaps = 43/340 (12%)
Query: 165 SAQEIATCNSR-NGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
S E AT N + G P P I WY+ G+R+E + +P + LL S +
Sbjct: 41 SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKD-DPRSHRM---------LLPSGSLFF 90
Query: 224 LRL---RKDDRDASFH-CAAHYSLPEG--RHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
LR+ RK D + C A L E + L+ V VG P+
Sbjct: 91 LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 278 AGWVREGDTVQLLC-RGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYG 336
G + + DGSP D+++E + + G L + + +G Y
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPL---------DDKDERITIR-GGKLMITYTRKSDAGKYV 200
Query: 337 CRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRW 396
C + + ++++ L P + L++ ++ SA C G P P +RW
Sbjct: 201 CVGTNMVGERESEVAELTVLE----RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 397 TKDSTPL-------GDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPE 449
KD L D L + +T G+Y C A V + TL VQ E
Sbjct: 257 RKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAE---NMVGKAEASATLTVQVGSE 313
Query: 450 LKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
++P+ D G VT C A G+P P + W + G
Sbjct: 314 PPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Score = 60.8 bits (146), Expect = 3e-09
Identities = 93/415 (22%), Positives = 151/415 (36%), Gaps = 78/415 (18%)
Query: 38 PPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRG 97
P V V G+ +++C P H + W + + + + ++T+ RG
Sbjct: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISW----------KKDGSPLDDKDERITI---RG 183
Query: 98 RSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG 157
G+L++ + D YVCV A L V +P + N
Sbjct: 184 ----------GKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSN-- 231
Query: 158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLS 217
L+V D + E C +R G+P P + W ++ L P+ R
Sbjct: 232 -LAVTVDDSAEFK-CEAR-GDPVPTVRWRKDDGEL-------PKSRYEIRD--------- 272
Query: 218 LTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTP 277
TL +R S+ C A E G+ ++ LT+ +E F V P
Sbjct: 273 -DHTLKIRKVTAGDMGSYTCVA-----ENMVGKAEASAT-LTVQVGSEPPHFVV-KPRDQ 324
Query: 278 AGWVREGDTVQLLCRGDGSPSP---------EYTLFRLQDEQEEV-LNVNLEGNLTLEGV 327
V G TV C G+P P + LF Q Q +V+ G+LT+ V
Sbjct: 325 V--VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 382
Query: 328 TRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLD--PLELSEGKV-LSLPLNSSAVVNC 384
R G Y C+ + A + LE+ D P + +G V ++ ++ + V++C
Sbjct: 383 QRSDVGYYICQT--LNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 440
Query: 385 SVHGLPTPALRWTKDSTPLG---------DGPMLSLSSITFDSNGTYVCEASLPT 430
G P P + W KD + + +L + G Y C AS P+
Sbjct: 441 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Score = 57.8 bits (138), Expect = 3e-08
Identities = 92/406 (22%), Positives = 150/406 (36%), Gaps = 66/406 (16%)
Query: 109 RLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQE 168
R+V DE YVCV R A L V + +P+ ++V E + E
Sbjct: 92 RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151
Query: 169 IATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRK 228
C G+P P I+W ++G L+ E T+R G L +T T RK
Sbjct: 152 ---CQPPRGHPEPTISWKKDGSPLDDKDERI--------TIR--GGKLMITYT-----RK 193
Query: 229 DDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQ 288
D + C + G +S LT+ E F V PS A V D+ +
Sbjct: 194 SDA-GKYVCVGTNMV-----GERESEVAELTV---LERPSF-VKRPSNLA--VTVDDSAE 241
Query: 289 LLCRGDGSPSPEYTLFRLQDEQ--EEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAAD 346
C G P P +R D + + + + L + VT G G+Y C E+
Sbjct: 242 FKCEARGDPVPTVR-WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENM--VG 298
Query: 347 DVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDST----- 401
+ S TL ++V P + + + + L + C G P PA+ W ++ +
Sbjct: 299 KAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLF 358
Query: 402 -----------PLGDGPMLSLSSITFDSNGTYVCE-----ASLPTVPVLSRTQNFTLLVQ 445
+ L+++++ G Y+C+ S+ T L T + +
Sbjct: 359 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD--VIADR 416
Query: 446 GSPELKTAEIEP--KADGSWREGDEVTLICSARGHPDPKLSWSQLG 489
P ++ + DG++ L C A G P P + W + G
Sbjct: 417 PPPVIRQGPVNQTVAVDGTF------VLSCVATGSPVPTILWRKDG 456
Score = 53.9 bits (128), Expect = 4e-07
Identities = 63/273 (23%), Positives = 105/273 (38%), Gaps = 38/273 (13%)
Query: 281 VREGDTVQLLCRGDGSPSPEYTLF----RLQDEQEEVLNVNL---EGNLTLEGVTRGQS- 332
V +G+ L C+ +G P+P + R++ ++++ + + G+L + G+
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 333 ----GTYGCRVEDYDAADDVQLSKTLELRVAYL-DPLELSEGKVLSLPLNSSAVVNCSV- 386
G Y C +Y +S L VA L D + V+ + + AV+ C
Sbjct: 100 RPDEGVYVCVARNYLGE---AVSHNASLEVAILRDDFRQNPSDVM-VAVGEPAVMECQPP 155
Query: 387 HGLPTPALRWTKDSTPLGD--------GPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQ 438
G P P + W KD +PL D G L ++ G YVC + S
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 439 NFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPG 498
T+L + S + + + D D C ARG P P + W + G +P
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVD------DSAEFKCEARGDPVPTVRWRKDDGE----LPK 265
Query: 499 RQGWVSSSLTLKVTSALSRD--GISCEASNPHG 529
+ + TLK+ + D +C A N G
Sbjct: 266 SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,470,650
Number of Sequences: 37866
Number of extensions: 1281730
Number of successful extensions: 7177
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 241
Number of HSP's that attempted gapping in prelim test: 3596
Number of HSP's gapped (non-prelim): 2474
length of query: 588
length of database: 18,247,518
effective HSP length: 108
effective length of query: 480
effective length of database: 14,157,990
effective search space: 6795835200
effective search space used: 6795835200
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.