Search of human proteins with 13540517

Search of human proteins with 13540517

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13540517 endothelial differentiation, sphingolipid
G-protein-coupled receptor, 8 [Homo sapiens]
         (398 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13540517 endothelial differentiation, sphingolipid G-protein-...   782   0.0  
gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens]         322   5e-88
gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens]         296   2e-80
gi|134244587 endothelial differentiation, sphingolipid G-protein...   280   2e-75
gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo sa...   245   6e-65
gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens]           195   5e-50
gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens]           195   5e-50
gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens]            189   5e-48
gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens]            174   2e-43
gi|4885325 G protein-coupled receptor 3 [Homo sapiens]                132   5e-31
gi|4885295 G protein-coupled receptor 12 [Homo sapiens]               131   1e-30
gi|4885341 G protein-coupled receptor 6 [Homo sapiens]                116   3e-26
gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens]          116   4e-26
gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens]          116   4e-26
gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens]          116   4e-26
gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens]          116   4e-26
gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens]           116   4e-26
gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens]          116   4e-26
gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens]         108   8e-24
gi|5174535 melanocortin 5 receptor [Homo sapiens]                     100   3e-21
gi|119508433 melanocortin 4 receptor [Homo sapiens]                    98   1e-20
gi|170671732 melanocortin 3 receptor [Homo sapiens]                    96   4e-20
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi...    85   1e-16
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]                 80   4e-15
gi|4505127 melanocortin 2 receptor [Homo sapiens]                      79   9e-15
gi|193083134 melanocortin 1 receptor [Homo sapiens]                    78   1e-14
gi|4557265 beta-1-adrenergic receptor [Homo sapiens]                   77   4e-14
gi|5921992 adenosine A2a receptor [Homo sapiens]                       77   4e-14
gi|4557865 somatostatin receptor 5 [Homo sapiens]                      72   7e-13
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]     72   1e-12

>gi|13540517 endothelial differentiation, sphingolipid
           G-protein-coupled receptor, 8 [Homo sapiens]
          Length = 398

 Score =  782 bits (2019), Expect = 0.0
 Identities = 398/398 (100%), Positives = 398/398 (100%)

Query: 1   MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV 60
           MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
Sbjct: 1   MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV 60

Query: 61  LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT 120
           LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
Sbjct: 61  LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT 120

Query: 121 ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD 180
           ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
Sbjct: 121 ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD 180

Query: 181 ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA 240
           ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
Sbjct: 181 ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA 240

Query: 241 RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL 300
           RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
Sbjct: 241 RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL 300

Query: 301 LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF 360
           LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
Sbjct: 301 LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF 360

Query: 361 SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD 398
           SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
Sbjct: 361 SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD 398


>gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens]
          Length = 382

 Score =  322 bits (824), Expect = 5e-88
 Identities = 176/372 (47%), Positives = 242/372 (65%), Gaps = 19/372 (5%)

Query: 13  EVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMF 72
           ++IV HYNYTGKL  +  +  + ++  +VV + +C FI+LEN+ VLL + +  +FH PM+
Sbjct: 23  DIIVRHYNYTGKLNISADKENS-IKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMY 81

Query: 73  LLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALE 132
             +G+L LSDLLAG AY AN+LLSG  T KL+PA WF REG +FVAL+ASV SLLAIA+E
Sbjct: 82  YFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIE 141

Query: 133 RSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKA 192
           R +TM +      S+  R   + +A W +SL+LG LP +GWNC+  L +CSTVLPLY K 
Sbjct: 142 RYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKH 201

Query: 193 YVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRT 252
           Y+LFC   F  +L +I  LY RIY  VR  +RRL  R       S  +R   +SLALL+T
Sbjct: 202 YILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRK----NISKASRSSEKSLALLKT 257

Query: 253 LSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRD 312
           + +VL  F+ACW PLF+LLLLDV C  +TC +L +A+ FL LA+ NS  NPIIYTLTN++
Sbjct: 258 VIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKE 317

Query: 313 LRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSS-PQRD 371
           +R A +R++     SC + PSG        +++G  +R +  G++ S S S+ SS PQ+D
Sbjct: 318 MRRAFIRIM-----SCCKCPSG--------DSAGKFKRPIIAGMEFSRSKSDNSSHPQKD 364

Query: 372 GLDTSGSTGSPG 383
             D   +  S G
Sbjct: 365 EGDNPETIMSSG 376


>gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens]
          Length = 378

 Score =  296 bits (758), Expect = 2e-80
 Identities = 155/345 (44%), Positives = 209/345 (60%), Gaps = 21/345 (6%)

Query: 6   LRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHP 65
           L+P   +E +  HY Y GKL G   +   G     V+ L +C+FIVLENL VL+ + ++ 
Sbjct: 9   LQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNN 68

Query: 66  RFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLS 125
           +FH  M+  +G+L L DLLAG AY  NIL+SG  T  LSP +WF REG +FVAL AS  S
Sbjct: 69  KFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCS 128

Query: 126 LLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTV 185
           LLAIA+ER LTM +  P   + R R   +    W ++  LG LP LGWNCL  L  CST+
Sbjct: 129 LLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTI 188

Query: 186 LPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPR 245
           LPLY+K Y+ FC+  F  IL  I  LYARIY  V++++R++                  R
Sbjct: 189 LPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKV-----------ANHNNSER 237

Query: 246 SLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPII 305
           S+ALLRT+ +V+  F+ACW PLF+L L+DVAC  + CP+L +A  F+ LA+ NS +NP+I
Sbjct: 238 SMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVI 297

Query: 306 YTLTNRDLRHALLRLVC-CGRHSCGR---------DPSGSQQSAS 340
           YTL ++++R A  RLVC C     G          DPS S+ S+S
Sbjct: 298 YTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSS 342


>gi|134244587 endothelial differentiation, sphingolipid
           G-protein-coupled receptor, 5 [Homo sapiens]
          Length = 353

 Score =  280 bits (715), Expect = 2e-75
 Identities = 156/327 (47%), Positives = 204/327 (62%), Gaps = 21/327 (6%)

Query: 3   SGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLG 62
           S  L P  V E    HYNYT +    +      + +  +V L  C  IV+ENL VL+ + 
Sbjct: 6   SEYLNPNKVQE----HYNYTKETLETQETTSRQVASAFIVIL--CCAIVVENLLVLIAVA 59

Query: 63  RHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTAS 122
           R+ +FH+ M+L LG+L  SDLLAG A+ AN LLSG +TL+L+P  WFAREG  F+ L+AS
Sbjct: 60  RNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSAS 119

Query: 123 VLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDAC 182
           V SLLAIA+ER + +A+          R L +  A+W +SL+LG LP LGWNCLG L+AC
Sbjct: 120 VFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEAC 179

Query: 183 STVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARR 242
           STVLPLYAK YVL  V  F  IL AI ALY RIYC VR++   + A              
Sbjct: 180 STVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAA-------------- 225

Query: 243 KPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLN 302
            P++LALL+T+++VL  F+ CW P F +LLLD ACP  +CP+L +A  F  ++  NSLLN
Sbjct: 226 -PQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLN 284

Query: 303 PIIYTLTNRDLRHALLRLVCCGRHSCG 329
           P+IYT  +RDLR  +LR + C R   G
Sbjct: 285 PVIYTWRSRDLRREVLRPLQCWRPGVG 311


>gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo
           sapiens]
          Length = 384

 Score =  245 bits (625), Expect = 6e-65
 Identities = 152/342 (44%), Positives = 198/342 (57%), Gaps = 22/342 (6%)

Query: 12  SEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPM 71
           S +IVLHYN++G+L G       GL A   + +A    +VLENL VL  +  H R    +
Sbjct: 22  SRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWV 81

Query: 72  FLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIAL 131
           +  L ++TLSDLL GAAY AN+LLSG  T +L+PA WF REG +F AL AS  SLL  A 
Sbjct: 82  YYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAG 141

Query: 132 ERSLTMARRGPAPVSSRG-----RTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVL 186
           ER  TM R    PV+  G     R        W ++ LLG+LP LGWNCL   D CS++L
Sbjct: 142 ERFATMVR----PVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLL 197

Query: 187 PLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRS 246
           PLY+K Y+LFC++ F G+LA I  LY  I+  V+A+ ++ P RP         ARRK R 
Sbjct: 198 PLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAP-RPA--------ARRKAR- 247

Query: 247 LALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQA-DPFLGLAMANSLLNPII 305
             LL+T+ ++LLAF+ CWGPLF LLL DV          L+  D  L LA+ NS +NPII
Sbjct: 248 -RLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPII 306

Query: 306 YTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGG 347
           Y+  +R++  A+L  +CCG    G    G    A A EA  G
Sbjct: 307 YSFRSREVCRAVLSFLCCGCLRLGMRGPG-DCLARAVEAHSG 347


>gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens]
          Length = 364

 Score =  195 bits (496), Expect = 5e-50
 Identities = 113/331 (34%), Positives = 185/331 (55%), Gaps = 11/331 (3%)

Query: 12  SEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPM 71
           +E I   YN +GK     +   + L     + + VC FI+L NL V++ +  + RFH P+
Sbjct: 27  NESIAFFYNRSGKHLATEWNTVSKLVMG--LGITVCIFIMLANLLVMVAIYVNRRFHFPI 84

Query: 72  FLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIAL 131
           + L+ +L  +D  AG AY   +  +GP T +L+ + W  R+G +  +LTASV +LLAIA+
Sbjct: 85  YYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAI 144

Query: 132 ERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAK 191
           ER +T+ R       S  R + +    W +++++G +P++GWNC+  ++ CS + PLY+ 
Sbjct: 145 ERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSD 204

Query: 192 AYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLR 251
           +Y++F  +  +     +  LYA I+  VR    R+         +S   R +   ++LL+
Sbjct: 205 SYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRH------SSGPRRNRDTMMSLLK 258

Query: 252 TLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNR 311
           T+ +VL AF+ CW P  +LLLLDV CP   C VL     FL LA  NS +NPIIY+  ++
Sbjct: 259 TVVIVLGAFIICWTPGLVLLLLDVCCPQ--CDVLAYEKFFLLLAEFNSAMNPIIYSYRDK 316

Query: 312 DLRHALLRLVCCGRHSCGRDPS-GSQQSASA 341
           ++     +++CC R      P+ GS +SAS+
Sbjct: 317 EMSATFRQILCCQRSENPTGPTEGSDRSASS 347


>gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens]
          Length = 364

 Score =  195 bits (496), Expect = 5e-50
 Identities = 113/331 (34%), Positives = 185/331 (55%), Gaps = 11/331 (3%)

Query: 12  SEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPM 71
           +E I   YN +GK     +   + L     + + VC FI+L NL V++ +  + RFH P+
Sbjct: 27  NESIAFFYNRSGKHLATEWNTVSKLVMG--LGITVCIFIMLANLLVMVAIYVNRRFHFPI 84

Query: 72  FLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIAL 131
           + L+ +L  +D  AG AY   +  +GP T +L+ + W  R+G +  +LTASV +LLAIA+
Sbjct: 85  YYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAI 144

Query: 132 ERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAK 191
           ER +T+ R       S  R + +    W +++++G +P++GWNC+  ++ CS + PLY+ 
Sbjct: 145 ERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSD 204

Query: 192 AYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLR 251
           +Y++F  +  +     +  LYA I+  VR    R+         +S   R +   ++LL+
Sbjct: 205 SYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRH------SSGPRRNRDTMMSLLK 258

Query: 252 TLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNR 311
           T+ +VL AF+ CW P  +LLLLDV CP   C VL     FL LA  NS +NPIIY+  ++
Sbjct: 259 TVVIVLGAFIICWTPGLVLLLLDVCCPQ--CDVLAYEKFFLLLAEFNSAMNPIIYSYRDK 316

Query: 312 DLRHALLRLVCCGRHSCGRDPS-GSQQSASA 341
           ++     +++CC R      P+ GS +SAS+
Sbjct: 317 EMSATFRQILCCQRSENPTGPTEGSDRSASS 347


>gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens]
          Length = 351

 Score =  189 bits (479), Expect = 5e-48
 Identities = 123/346 (35%), Positives = 186/346 (53%), Gaps = 19/346 (5%)

Query: 12  SEVIVLHYNYTGKLRGARYQPGAGLRADAVVC---LAVCAFIVLENLAVLLVLGRHPRFH 68
           +E I   YN +GK   + ++P      D VV    L V   ++L NL V+  +  + RFH
Sbjct: 10  NETIGFFYNNSGKELSSHWRP-----KDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFH 64

Query: 69  APMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLA 128
            P++ LLG+L  +DL AG AY   +  +GP T +LS   WF R+G +  +LTASV +LLA
Sbjct: 65  QPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLA 124

Query: 129 IALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPL 188
           IA+ER  ++          RGR + +    W  +L LGLLPA  W+CL  LD CS + PL
Sbjct: 125 IAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPL 184

Query: 189 YAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLA 248
            +++Y+    L+ + +   + A+Y RI+  VR   +R+      A   S   R +  +L+
Sbjct: 185 LSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRM------AEHVSCHPRYRETTLS 238

Query: 249 LLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTL 308
           L++T+ ++L AFV CW P  ++LLLD      +C VL     FL LA ANSL+N  +Y+ 
Sbjct: 239 LVKTVVIILGAFVVCWTPGQVVLLLD-GLGCESCNVLAVEKYFLLLAEANSLVNAAVYSC 297

Query: 309 TNRDLRHALLRLVCCGRHSCGRDPS-GSQQSASAAEASGGLRRCLP 353
            + ++R    RL+CC   +C R  +  S    S+A+     R  LP
Sbjct: 298 RDAEMRRTFRRLLCC---ACLRQSTRESVHYTSSAQGGASTRIMLP 340


>gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens]
          Length = 353

 Score =  174 bits (440), Expect = 2e-43
 Identities = 98/291 (33%), Positives = 164/291 (56%), Gaps = 9/291 (3%)

Query: 35  GLRADAVVCLAV--CAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAAN 92
           G +   V+C+    C FI   N  V+  + ++ +FH P + LL +L  +D  AG AY   
Sbjct: 27  GTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFL 86

Query: 93  ILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTL 152
           +  +GP++  L+   WF R+G +  +LTAS+ +LL IA+ER +++ R       ++ R  
Sbjct: 87  MFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVT 146

Query: 153 AMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALY 212
            +    W +++ +G +P LGWNCL  + ACS++ P+Y+++Y++F  ++ +     +  +Y
Sbjct: 147 LLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVY 206

Query: 213 ARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLL 272
            RIY  V+     L   P T+G+ S   RR P  + L++T+  VL AFV CW P  ++LL
Sbjct: 207 LRIYVYVKRKTNVL--SPHTSGSIS--RRRTP--MKLMKTVMTVLGAFVVCWTPGLVVLL 260

Query: 273 LDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCC 323
           LD     R C V      FL LA+ NS++NPIIY+  + D+   + +++CC
Sbjct: 261 LD-GLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICC 310


>gi|4885325 G protein-coupled receptor 3 [Homo sapiens]
          Length = 330

 Score =  132 bits (332), Expect = 5e-31
 Identities = 102/291 (35%), Positives = 148/291 (50%), Gaps = 26/291 (8%)

Query: 39  DAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAA---YAANILL 95
           D V+C++    +  EN  V+ ++   P F APMFLL+GSL ++DLLAG     + A +  
Sbjct: 44  DVVLCISG-TLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFC 102

Query: 96  SGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPA-PVSSRGRTLAM 154
            G   + L         G + +A TAS+ SLLAI ++R L++         ++  RT  M
Sbjct: 103 IGSAEMSL------VLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVM 156

Query: 155 AAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYAR 214
            A  WG +L LGLLP L WNCL  L  C  V PL +K +++   +AF  +   +  LYA+
Sbjct: 157 LALVWGGALGLGLLPVLAWNCLDGLTTCGVVYPL-SKNHLVVLAIAFFMVFGIMLQLYAQ 215

Query: 215 IYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLD 274
           I   V  +A+++  +      +   A RK      + TL+VVL AF ACW P  +  LL 
Sbjct: 216 ICRIVCRHAQQIALQRHLLPASHYVATRKG-----IATLAVVLGAFAACWLPFTVYCLLG 270

Query: 275 VA--CPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCC 323
            A   P  T   LL        A  NS++NPIIY   N+D++  L  + CC
Sbjct: 271 DAHSPPLYTYLTLLP-------ATYNSMINPIIYAFRNQDVQKVLWAVCCC 314


>gi|4885295 G protein-coupled receptor 12 [Homo sapiens]
          Length = 334

 Score =  131 bits (329), Expect = 1e-30
 Identities = 102/292 (34%), Positives = 146/292 (50%), Gaps = 27/292 (9%)

Query: 39  DAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGP 98
           D V+C +    I  EN  V+L++  +P   APMFLL+GSL L+DLLAG     N + +  
Sbjct: 48  DIVLCTSG-TLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFA-- 104

Query: 99  LTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLA----M 154
             L  S A      G +  + +ASV SLLAI ++R L++     A      RT+     M
Sbjct: 105 -YLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYY---ALTYHSERTVTFTYVM 160

Query: 155 AAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYAR 214
               WG S+ LGLLP +GWNCL     CS V PL  K       ++F+ + A +  LY +
Sbjct: 161 LVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPL-TKNNAAILSVSFLFMFALMLQLYIQ 219

Query: 215 IYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLL-LLL 273
           I   V  +A ++  +     T+     RK  S     TL+++L  F ACW P  L  L+ 
Sbjct: 220 ICKIVMRHAHQIALQHHFLATSHYVTTRKGVS-----TLAIILGTFAACWMPFTLYSLIA 274

Query: 274 DVACPA-RTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCG 324
           D   P+  T   LL        A  NS++NP+IY   N++++ AL  L+CCG
Sbjct: 275 DYTYPSIYTYATLLP-------ATYNSIINPVIYAFRNQEIQKALC-LICCG 318


>gi|4885341 G protein-coupled receptor 6 [Homo sapiens]
          Length = 362

 Score =  116 bits (291), Expect = 3e-26
 Identities = 100/294 (34%), Positives = 138/294 (46%), Gaps = 34/294 (11%)

Query: 39  DAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGP 98
           D ++C++    I  EN  V+ ++   P    PMF+L+GSL  +DLLAG     + +    
Sbjct: 76  DVLLCVSGTV-IAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQ-- 132

Query: 99  LTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLA----M 154
             L  S  +     G +  +  ASV SLLAI ++R L++     A      RTL     +
Sbjct: 133 -YLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYN---ALTYYSRRTLLGVHLL 188

Query: 155 AAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYAR 214
            AA W VSL LGLLP LGWNCL    ACS V PL A+++V     AF  +   +  LY R
Sbjct: 189 LAATWTVSLGLGLLPVLGWNCLAERAACSVVRPL-ARSHVALLSAAFFMVFGIMLHLYVR 247

Query: 215 IYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLD 274
           I   V  +A ++  +          A RK      + TL+VVL  F A W P        
Sbjct: 248 ICQVVWRHAHQIALQQHCLAPPHLAATRKG-----VGTLAVVLGTFGASWLPF------- 295

Query: 275 VACPARTCPVLLQADP------FLGLAMANSLLNPIIYTLTNRDLRHALLRLVC 322
               A  C V    DP       L  A  NS++NPIIY   N++++ AL  L+C
Sbjct: 296 ----AIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLC 345


>gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens]
          Length = 472

 Score =  116 bits (290), Expect = 4e-26
 Identities = 87/293 (29%), Positives = 144/293 (49%), Gaps = 17/293 (5%)

Query: 38  ADAVVCLAVCAFIVLENLAVLLVLGRHPRFHA-PMFLLLGSLTLSDLLAGAAYAANILLS 96
           A AV+ L +  F VLENL VL V+         P +  +GSL ++DLL    +  + +  
Sbjct: 118 AIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDF 177

Query: 97  GPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARR-GPAPVSSRGRTLAMA 155
                K S  ++  + GGV  + TASV SL   A++R +++ R      + +R + +   
Sbjct: 178 HVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAF 237

Query: 156 AAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARI 215
              W +++++ +LP LGWNC      CS + P   + Y++F +     +L  I   Y  I
Sbjct: 238 CLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYI 297

Query: 216 YCQVRANARRLPARPGTAGT----TS-------TRARRKPRSLALLRTLSVVLLAFVACW 264
             +  ++A R+  R GT  +    TS       TR  +    + L +TL ++L+  + CW
Sbjct: 298 LWKAHSHAVRMIQR-GTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356

Query: 265 GPLFLLLLLDVACPARTCPVLLQADPFLG-LAMANSLLNPIIYTLTNRDLRHA 316
           GPL  +++ DV    +   ++     F   L + NS +NPIIY L ++DLRHA
Sbjct: 357 GPLLAIMVYDVF--GKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHA 407


>gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens]
          Length = 472

 Score =  116 bits (290), Expect = 4e-26
 Identities = 87/293 (29%), Positives = 144/293 (49%), Gaps = 17/293 (5%)

Query: 38  ADAVVCLAVCAFIVLENLAVLLVLGRHPRFHA-PMFLLLGSLTLSDLLAGAAYAANILLS 96
           A AV+ L +  F VLENL VL V+         P +  +GSL ++DLL    +  + +  
Sbjct: 118 AIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDF 177

Query: 97  GPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARR-GPAPVSSRGRTLAMA 155
                K S  ++  + GGV  + TASV SL   A++R +++ R      + +R + +   
Sbjct: 178 HVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAF 237

Query: 156 AAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARI 215
              W +++++ +LP LGWNC      CS + P   + Y++F +     +L  I   Y  I
Sbjct: 238 CLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYI 297

Query: 216 YCQVRANARRLPARPGTAGT----TS-------TRARRKPRSLALLRTLSVVLLAFVACW 264
             +  ++A R+  R GT  +    TS       TR  +    + L +TL ++L+  + CW
Sbjct: 298 LWKAHSHAVRMIQR-GTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356

Query: 265 GPLFLLLLLDVACPARTCPVLLQADPFLG-LAMANSLLNPIIYTLTNRDLRHA 316
           GPL  +++ DV    +   ++     F   L + NS +NPIIY L ++DLRHA
Sbjct: 357 GPLLAIMVYDVF--GKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHA 407


>gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens]
          Length = 472

 Score =  116 bits (290), Expect = 4e-26
 Identities = 87/293 (29%), Positives = 144/293 (49%), Gaps = 17/293 (5%)

Query: 38  ADAVVCLAVCAFIVLENLAVLLVLGRHPRFHA-PMFLLLGSLTLSDLLAGAAYAANILLS 96
           A AV+ L +  F VLENL VL V+         P +  +GSL ++DLL    +  + +  
Sbjct: 118 AIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDF 177

Query: 97  GPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARR-GPAPVSSRGRTLAMA 155
                K S  ++  + GGV  + TASV SL   A++R +++ R      + +R + +   
Sbjct: 178 HVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAF 237

Query: 156 AAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARI 215
              W +++++ +LP LGWNC      CS + P   + Y++F +     +L  I   Y  I
Sbjct: 238 CLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYI 297

Query: 216 YCQVRANARRLPARPGTAGT----TS-------TRARRKPRSLALLRTLSVVLLAFVACW 264
             +  ++A R+  R GT  +    TS       TR  +    + L +TL ++L+  + CW
Sbjct: 298 LWKAHSHAVRMIQR-GTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356

Query: 265 GPLFLLLLLDVACPARTCPVLLQADPFLG-LAMANSLLNPIIYTLTNRDLRHA 316
           GPL  +++ DV    +   ++     F   L + NS +NPIIY L ++DLRHA
Sbjct: 357 GPLLAIMVYDVF--GKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHA 407


>gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens]
          Length = 472

 Score =  116 bits (290), Expect = 4e-26
 Identities = 87/293 (29%), Positives = 144/293 (49%), Gaps = 17/293 (5%)

Query: 38  ADAVVCLAVCAFIVLENLAVLLVLGRHPRFHA-PMFLLLGSLTLSDLLAGAAYAANILLS 96
           A AV+ L +  F VLENL VL V+         P +  +GSL ++DLL    +  + +  
Sbjct: 118 AIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDF 177

Query: 97  GPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARR-GPAPVSSRGRTLAMA 155
                K S  ++  + GGV  + TASV SL   A++R +++ R      + +R + +   
Sbjct: 178 HVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAF 237

Query: 156 AAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARI 215
              W +++++ +LP LGWNC      CS + P   + Y++F +     +L  I   Y  I
Sbjct: 238 CLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYI 297

Query: 216 YCQVRANARRLPARPGTAGT----TS-------TRARRKPRSLALLRTLSVVLLAFVACW 264
             +  ++A R+  R GT  +    TS       TR  +    + L +TL ++L+  + CW
Sbjct: 298 LWKAHSHAVRMIQR-GTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356

Query: 265 GPLFLLLLLDVACPARTCPVLLQADPFLG-LAMANSLLNPIIYTLTNRDLRHA 316
           GPL  +++ DV    +   ++     F   L + NS +NPIIY L ++DLRHA
Sbjct: 357 GPLLAIMVYDVF--GKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHA 407


>gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens]
          Length = 472

 Score =  116 bits (290), Expect = 4e-26
 Identities = 87/293 (29%), Positives = 144/293 (49%), Gaps = 17/293 (5%)

Query: 38  ADAVVCLAVCAFIVLENLAVLLVLGRHPRFHA-PMFLLLGSLTLSDLLAGAAYAANILLS 96
           A AV+ L +  F VLENL VL V+         P +  +GSL ++DLL    +  + +  
Sbjct: 118 AIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDF 177

Query: 97  GPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARR-GPAPVSSRGRTLAMA 155
                K S  ++  + GGV  + TASV SL   A++R +++ R      + +R + +   
Sbjct: 178 HVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAF 237

Query: 156 AAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARI 215
              W +++++ +LP LGWNC      CS + P   + Y++F +     +L  I   Y  I
Sbjct: 238 CLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYI 297

Query: 216 YCQVRANARRLPARPGTAGT----TS-------TRARRKPRSLALLRTLSVVLLAFVACW 264
             +  ++A R+  R GT  +    TS       TR  +    + L +TL ++L+  + CW
Sbjct: 298 LWKAHSHAVRMIQR-GTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356

Query: 265 GPLFLLLLLDVACPARTCPVLLQADPFLG-LAMANSLLNPIIYTLTNRDLRHA 316
           GPL  +++ DV    +   ++     F   L + NS +NPIIY L ++DLRHA
Sbjct: 357 GPLLAIMVYDVF--GKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHA 407


>gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens]
          Length = 439

 Score =  116 bits (290), Expect = 4e-26
 Identities = 87/293 (29%), Positives = 144/293 (49%), Gaps = 17/293 (5%)

Query: 38  ADAVVCLAVCAFIVLENLAVLLVLGRHPRFHA-PMFLLLGSLTLSDLLAGAAYAANILLS 96
           A AV+ L +  F VLENL VL V+         P +  +GSL ++DLL    +  + +  
Sbjct: 85  AIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDF 144

Query: 97  GPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARR-GPAPVSSRGRTLAMA 155
                K S  ++  + GGV  + TASV SL   A++R +++ R      + +R + +   
Sbjct: 145 HVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAF 204

Query: 156 AAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARI 215
              W +++++ +LP LGWNC      CS + P   + Y++F +     +L  I   Y  I
Sbjct: 205 CLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYI 264

Query: 216 YCQVRANARRLPARPGTAGT----TS-------TRARRKPRSLALLRTLSVVLLAFVACW 264
             +  ++A R+  R GT  +    TS       TR  +    + L +TL ++L+  + CW
Sbjct: 265 LWKAHSHAVRMIQR-GTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 323

Query: 265 GPLFLLLLLDVACPARTCPVLLQADPFLG-LAMANSLLNPIIYTLTNRDLRHA 316
           GPL  +++ DV    +   ++     F   L + NS +NPIIY L ++DLRHA
Sbjct: 324 GPLLAIMVYDVF--GKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHA 374


>gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens]
          Length = 360

 Score =  108 bits (270), Expect = 8e-24
 Identities = 85/281 (30%), Positives = 131/281 (46%), Gaps = 12/281 (4%)

Query: 38  ADAVVCLAVCAFIVLENLAVL-LVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLS 96
           A AV+C  +     LEN+AVL L+L  H     P +L +GSL  +D LA   +A + +  
Sbjct: 35  AVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNF 94

Query: 97  GPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPA--PVSSRGRTLAM 154
                  S A++  + G V +  TASV SLL  A++R L + R  P+   + +RGR L  
Sbjct: 95  HVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCL-RYPPSYKALLTRGRALVT 153

Query: 155 AAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYAR 214
               W +S L+  LP +GW C  R   CS + PL    Y+L  +L    + + I   Y  
Sbjct: 154 LGIMWVLSALVSYLPLMGWTCCPR--PCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGH 211

Query: 215 IYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLD 274
           +  +   +   L            R R   R   L +TL +VL   + CW P+  L+   
Sbjct: 212 VLWKAHQHVASLSGHQDRQVPGMARMRLDVR---LAKTLGLVLAVLLICWFPVLALMAHS 268

Query: 275 VACPARTCPVLLQADPFLG-LAMANSLLNPIIYTLTNRDLR 314
           +A        + +A  F   L + NS++NP+IY L + ++R
Sbjct: 269 LA--TTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIR 307


>gi|5174535 melanocortin 5 receptor [Homo sapiens]
          Length = 325

 Score =  100 bits (248), Expect = 3e-21
 Identities = 81/302 (26%), Positives = 151/302 (50%), Gaps = 39/302 (12%)

Query: 35  GLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANIL 94
           G+  +  + L V +  +LEN+ V+  + ++   H+PM+  + SL ++D+L   + A   +
Sbjct: 37  GIAVEVFLTLGVIS--LLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETI 94

Query: 95  LSGPLTLK-LSPALWFAR------EGGVFVALTASVLSLLAIALERSLTM--ARRGPAPV 145
               L  K L  A  F R      +  + +++ AS+ SLLAIA++R +T+  A R    +
Sbjct: 95  TIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIM 154

Query: 146 SSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKA-YVLFCVLA-FVG 203
           ++R R+ A+ A  W               C G    C  V  LY+++ YV+ C+++ F  
Sbjct: 155 TAR-RSGAIIAGIWAF-------------CTG----CGIVFILYSESTYVILCLISMFFA 196

Query: 204 ILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVAC 263
           +L  + +LY  ++   R + +R+ A PG +        R+  S+    T++++L  F  C
Sbjct: 197 MLFLLVSLYIHMFLLARTHVKRIAALPGASSA------RQRTSMQGAVTVTMLLGVFTVC 250

Query: 264 WGPLFLLLLLDVACPART--CPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLV 321
           W P FL L L ++CP        +   + +L L M NS+++P+IY   ++++R     ++
Sbjct: 251 WAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEII 310

Query: 322 CC 323
           CC
Sbjct: 311 CC 312


>gi|119508433 melanocortin 4 receptor [Homo sapiens]
          Length = 332

 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 76/319 (23%), Positives = 147/319 (46%), Gaps = 34/319 (10%)

Query: 17  LHYNYTGKLRGARYQPGA---GLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFL 73
           LH N +  L G  Y  G     L     V + +    +LEN+ V++ + ++   H+PM+ 
Sbjct: 23  LHSNASESL-GKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYF 81

Query: 74  LLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWF------AREGGVFVALTASVLSLL 127
            + SL ++D+L   +  +  ++   L    + A  F        +  +  +L AS+ SLL
Sbjct: 82  FICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLL 141

Query: 128 AIALERSLTM-ARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVL 186
           +IA++R  T+        + +  R   + +  W    + G+L                ++
Sbjct: 142 SIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGIL---------------FII 186

Query: 187 PLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRS 246
              + A ++  +  F  +LA + +LY  ++   R + +R+   PGT       A R+  +
Sbjct: 187 YSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTG------AIRQGAN 240

Query: 247 LALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQA--DPFLGLAMANSLLNPI 304
           +    TL++++  FV CW P FL L+  ++CP     V   +  + +L L M NS+++P+
Sbjct: 241 MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL 300

Query: 305 IYTLTNRDLRHALLRLVCC 323
           IY L +++LR     ++CC
Sbjct: 301 IYALRSQELRKTFKEIICC 319


>gi|170671732 melanocortin 3 receptor [Homo sapiens]
          Length = 323

 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 76/295 (25%), Positives = 145/295 (49%), Gaps = 37/295 (12%)

Query: 42  VCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTL 101
           V L++    +LEN+ V+L + R+   H+PM+  L SL ++D+L   + A   ++   + +
Sbjct: 44  VFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIM---IAI 100

Query: 102 KLSPALWFAR----------EGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRT 151
             S  L F            +  + ++L AS+ +LLAIA++R +T+        + R  +
Sbjct: 101 VHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIF------YALRYHS 154

Query: 152 LAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKA-YVLFCVLA-FVGILAAIC 209
           +     A      L L+ A+ W C G    C  V  +Y+++  V+ C++  F  ++  + 
Sbjct: 155 IMTVRKA------LTLIVAI-WVCCG---VCGVVFIVYSESKMVIVCLITMFFAMMLLMG 204

Query: 210 ALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFL 269
            LY  ++   R + +R+ A P   G     A ++   +    T++++L  F+ CW P FL
Sbjct: 205 TLYVHMFLFARLHVKRIAALPPADGV----APQQHSCMKGAVTITILLGVFIFCWAPFFL 260

Query: 270 LLLLDVACPARTCPVLLQA--DPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVC 322
            L+L + CP     +   A  + +L L M NS+++P+IY   + +LR+    ++C
Sbjct: 261 HLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILC 315


>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
           sapiens]
          Length = 440

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 109/396 (27%), Positives = 153/396 (38%), Gaps = 53/396 (13%)

Query: 32  PGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAA 91
           PG      A +C+ +       +L + L+  +    +   F L+ SL  SDL+ G     
Sbjct: 23  PGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLV-SLFTSDLMVG----- 76

Query: 92  NILLSGPLTLKLSPALWFAREGGVFV-------ALTASVLSLLAIALERSLTMARRGPAP 144
            +++  P  L      W    G   +         +AS+L+L  I+L+R L +    P  
Sbjct: 77  -LVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLIL--SPLR 133

Query: 145 VSSRG---RTLAMAAAAWGVSLLLGLLPAL-GWNCLG--RLDACSTVLPLYAKAYVLFCV 198
              R    R LA+   AW ++ L   LP L GW+ LG  R         L +  +VL   
Sbjct: 134 YKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVAS 193

Query: 199 -LAFVGILAAICALYARIYCQVRANARRLPA-------------------RPGTAGTTST 238
            L F     AIC  Y RI    R  A ++ +                   RPG     S 
Sbjct: 194 GLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSR 253

Query: 239 RARRKPRSLALLR--TLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAM 296
           R   K    AL    TL ++L  F   W P F+  ++   C   + P L     +LG   
Sbjct: 254 RLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCIS-PGLFDVLTWLGYC- 311

Query: 297 ANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGL 356
            NS +NPIIY L  RD + AL R + C R  C R+   S  S S   +  G R    PGL
Sbjct: 312 -NSTMNPIIYPLFMRDFKRALGRFLPCPR--CPRERQASLASPSLRTSHSGPR----PGL 364

Query: 357 DGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLV 392
                      P  D    +GS GS G    A+ L+
Sbjct: 365 SLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLL 400


>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 96/376 (25%), Positives = 156/376 (41%), Gaps = 59/376 (15%)

Query: 45  AVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAA---YAANILLSGPLTL 101
           A   F ++ N+ V+L +  +     P    + +L ++DLL       ++A + + G   L
Sbjct: 54  AFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVL 113

Query: 102 -KLSPALWFAREGGVFVALTASVLSLLAIALERSLTM--ARRGPAPVSSRGRTLAMAAAA 158
            ++   +W A +    +  TAS+LSL AI+++R + +  + + P  V+ R   LA+ +  
Sbjct: 114 GRIFCDIWAAVD---VLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSV- 169

Query: 159 WGVSLLLGLLPALGWNCLGRLD--ACS-TVLPLYAKAYVLFCVL-AFVGILAAICALYAR 214
           W +S ++ + P LGW      D   C  T  P YA    LF  L +F   LA I  +Y R
Sbjct: 170 WVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYA----LFSSLGSFYIPLAVILVMYCR 225

Query: 215 IYCQVRANARRLPA---------------------RPGTAGTTSTRARRKPRSLAL---- 249
           +Y   +   + L A                        T  +T  +      S+A+    
Sbjct: 226 VYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFK 285

Query: 250 -------LRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLN 302
                   +TL +V+  F+ CW P F+ L L         P  +    F  L   NS LN
Sbjct: 286 FSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFW-LGYFNSCLN 344

Query: 303 PIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSG 362
           PIIY  ++++ + A +R++ C     GR      +        GG      P   G    
Sbjct: 345 PIIYPCSSKEFKRAFVRILGCQCRGRGR------RRRRRRRRLGGCAYTYRPWTRG--GS 396

Query: 363 SERSSPQRDGLDTSGS 378
            ERS  ++D LD SGS
Sbjct: 397 LERSQSRKDSLDDSGS 412


>gi|4505127 melanocortin 2 receptor [Homo sapiens]
          Length = 297

 Score = 78.6 bits (192), Expect = 9e-15
 Identities = 79/288 (27%), Positives = 130/288 (45%), Gaps = 42/288 (14%)

Query: 51  VLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAY--AANILLSGPLTLKLSPALW 108
           VLENL VLL + ++    APM+  + SL +SD+L G+ Y    NIL+       L P   
Sbjct: 39  VLENLIVLLAVFKNKNLQAPMYFFICSLAISDML-GSLYKILENILIILRNMGYLKPRGS 97

Query: 109 FAREG-----GVFV-ALTASVLSLLAIALERSLTM--ARRGPAPVSSRGRTLAMAAAAWG 160
           F          +FV +L  S+ SL  IA +R +T+  A R  + V+ R RT+ +    W 
Sbjct: 98  FETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMR-RTVVVLTVIWT 156

Query: 161 VSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVR 220
                G+   +  + +  +   +++ PL               +L  I  LY  ++   R
Sbjct: 157 FCTGTGITMVIFSHHVPTVITFTSLFPL---------------MLVFILCLYVHMFLLAR 201

Query: 221 ANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPAR 280
           ++ R++   P        RA  K        TL+++L  F+ CW P  L +LL   CP+ 
Sbjct: 202 SHTRKISTLP--------RANMKGAI-----TLTILLGVFIFCWAPFVLHVLLMTFCPSN 248

Query: 281 T-CPVLLQADPFLG-LAMANSLLNPIIYTLTNRDLRHALLRLVCCGRH 326
             C   +      G L M N++++P IY   + +LR A  +++ C R+
Sbjct: 249 PYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRY 296


>gi|193083134 melanocortin 1 receptor [Homo sapiens]
          Length = 317

 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 79/289 (27%), Positives = 129/289 (44%), Gaps = 42/289 (14%)

Query: 51  VLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYA---ANILLSGPLTLKLSPAL 107
           ++EN  V+  + ++   H+PM+  +  L LSDLL   +     A ILL     L    A+
Sbjct: 53  LVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAV 112

Query: 108 WFAREGGVFVALTASVLSLL----AIALER--SLTMARRGPAPVSSRGRTLAMAAAAWGV 161
               +  + V   +S+LS L    AIA++R  S+  A R  + V+   R     AA W  
Sbjct: 113 LQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLP-RARRAVAAIWVA 171

Query: 162 SLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFC-VLAFVGILAAICALYARIYCQVR 220
           S++   L                 +  Y    VL C V+ F+ +L  +  LY  +  +  
Sbjct: 172 SVVFSTL----------------FIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARAC 215

Query: 221 ANARRLPARPGTAGTTSTRARRKPR----SLALLRTLSVVLLAFVACWGPLFLLLLLDVA 276
            +A+         G      R++P      L    TL+++L  F  CWGP FL L L V 
Sbjct: 216 QHAQ---------GIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVL 266

Query: 277 CPAR-TCPVLLQ-ADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCC 323
           CP   TC  + +  + FL L + N++++P+IY   +++LR  L  ++ C
Sbjct: 267 CPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTC 315


>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
          Length = 477

 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 106/401 (26%), Positives = 154/401 (38%), Gaps = 90/401 (22%)

Query: 29  RYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAG-- 86
           ++  G GL    +V L     IV  N+ V++ + + PR      L + SL  +DL+ G  
Sbjct: 56  QWTAGMGLLMALIVLL-----IVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLL 110

Query: 87  -AAYAANILLSGPLTL-KLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAP 144
              + A I++ G          LW + +    + +TAS+ +L  IAL+R L +    P  
Sbjct: 111 VVPFGATIVVWGRWEYGSFFCELWTSVD---VLCVTASIETLCVIALDRYLAIT--SPFR 165

Query: 145 VSS---RGRTLAMAAAAWGVSLLLGLLPAL-GW---------NCLGRLDACSTVL-PLYA 190
             S   R R   +    W +S L+  LP L  W          C      C  V    YA
Sbjct: 166 YQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYA 225

Query: 191 KA------YVLFCVLAFVGILAAICALYARIYCQVRANARRL------------------ 226
            A      YV  C++AFV         Y R++ + +   +++                  
Sbjct: 226 IASSVVSFYVPLCIMAFV---------YLRVFREAQKQVKKIDSCERRFLGGPARPPSPS 276

Query: 227 ------------PARPGTAGTTSTRA------RRKPRSLAL-----LRTLSVVLLAFVAC 263
                       P RP  A  T+  A      RR  R +AL     L+TL +++  F  C
Sbjct: 277 PSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLC 336

Query: 264 WGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCC 323
           W P FL  ++  A      P  L    F  L  ANS  NPIIY   + D R A   L+CC
Sbjct: 337 WLPFFLANVVK-AFHRELVPDRLFVF-FNWLGYANSAFNPIIY-CRSPDFRKAFQGLLCC 393

Query: 324 GRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSE 364
            R +  R  +          ASG L R  PP   G+ S  +
Sbjct: 394 ARRAARRRHA---THGDRPRASGCLARPGPPPSPGAASDDD 431


>gi|5921992 adenosine A2a receptor [Homo sapiens]
          Length = 412

 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 96/396 (24%), Positives = 159/396 (40%), Gaps = 58/396 (14%)

Query: 32  PGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAA 91
           P  G      V LA+    +L N+ V   +  +          + SL  +D+  G     
Sbjct: 2   PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVG----- 56

Query: 92  NILLSGPLTLKLSPALWFAREGGVFVAL------TASVLSLLAIALERSLTMARRGPAPV 145
             +L+ P  + +S     A  G +F+A        +S+ SLLAIA++R + +      P+
Sbjct: 57  --VLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIR----IPL 110

Query: 146 SSRG-----RTLAMAAAAWGVSLLLGLLPALGWNCLGRLD--------------AC--ST 184
              G     R   + A  W +S  +GL P LGWN  G+                AC    
Sbjct: 111 RYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFED 170

Query: 185 VLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRK- 243
           V+P+    Y  F     V +L  +  +Y RI+   R   +++ ++P        RAR   
Sbjct: 171 VVPMNYMVYFNFFACVLVPLLLML-GVYLRIFLAARRQLKQMESQP----LPGERARSTL 225

Query: 244 PRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNP 303
            + +   ++L++++  F  CW PL ++      CP  +   L      + L+  NS++NP
Sbjct: 226 QKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNP 285

Query: 304 IIYTLTNRDLRHALLRLVCCG--RHSCGRDPSGSQQSASAAEASGGLRRCL-----PPGL 356
            IY    R+ R    +++     R       +G+     AA  S G +  L     PPG+
Sbjct: 286 FIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGV 345

Query: 357 --DGSFSGSE-RSSPQRDGLDTSGST----GSPGAP 385
             +GS    E R +    GL + GS     G+ G P
Sbjct: 346 WANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLP 381


>gi|4557865 somatostatin receptor 5 [Homo sapiens]
          Length = 364

 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 84/321 (26%), Positives = 141/321 (43%), Gaps = 36/321 (11%)

Query: 32  PGAGLRADAV--VCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLL----- 84
           P AG RA  V  + L VCA  +  N  V+ V+ R  +      + + +L ++D+L     
Sbjct: 34  PSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGL 93

Query: 85  --AGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGP 142
                  AA+    GP+  +L   L    +G   V    SV  L  ++++R L +     
Sbjct: 94  PFLATQNAASFWPFGPVLCRLVMTL----DG---VNQFTSVFCLTVMSVDRYLAVVHPLS 146

Query: 143 APVSSRGRTLAMA-AAAWGVSLLLGLLPALGWNCLGRLDACSTVLP----LYAKAYVLF- 196
           +    R R   +A AAAW +SL + L P L +  +     C+   P    L+   ++++ 
Sbjct: 147 SARWRRPRVAKLASAAAWVLSLCMSL-PLLVFADVQEGGTCNASWPEPVGLWGAVFIIYT 205

Query: 197 CVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVV 256
            VL F   L  IC  Y  I  +VRA   R+       G    R+ RK     + R + VV
Sbjct: 206 AVLGFFAPLLVICLCYLLIVVKVRAAGVRV-------GCVRRRSERK-----VTRMVLVV 253

Query: 257 LLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLG-LAMANSLLNPIIYTLTNRDLRH 315
           +L F  CW P F + ++++A      P       F+  L+ ANS  NP++Y   + + R 
Sbjct: 254 VLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQ 313

Query: 316 ALLRLVCCGRHSCGRDPSGSQ 336
           +  +++C  + S  +D   ++
Sbjct: 314 SFQKVLCLRKGSGAKDADATE 334


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 87/350 (24%), Positives = 148/350 (42%), Gaps = 54/350 (15%)

Query: 31  QPGAGLRADAVVCLAVCA-----FIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLA 85
           QP A +     + L V       F VL N+ V+L +  H   H+     + +L ++DLL 
Sbjct: 16  QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL 75

Query: 86  GAA---YAANILLSGPLTL-KLSPALWFAREGGVFVALTASVLSLLAIALERSLTMAR-- 139
            +    ++A   + G     ++   +W A +    +  TAS++ L  I+++R + ++   
Sbjct: 76  TSTVLPFSAIFEVLGYWAFGRVFCNIWAAVD---VLCCTASIMGLCIISIDRYIGVSYPL 132

Query: 140 RGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAK-AYVLFCV 198
           R P  V+ R R L      W +SL++ + P  GW      D   T+  +  +  YVLF  
Sbjct: 133 RYPTIVTQR-RGLMALLCVWALSLVISIGPLFGWRQPAPED--ETICQINEEPGYVLFSA 189

Query: 199 L-AFVGILAAICALYARIYC---------------------QVRANARRLPARPGTAGTT 236
           L +F   LA I  +Y R+Y                      QV     R  A  G +G  
Sbjct: 190 LGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMA 249

Query: 237 STRAR--------RKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACP-ARTCPVLLQ 287
           S + +        +  R     +TL +V+  FV CW P FL++ +    P  +    + +
Sbjct: 250 SAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFK 309

Query: 288 ADPFLGLAMANSLLNPIIYTLTNRDLRHA---LLRLVCCGRHSCGRDPSG 334
              +LG    NS +NPIIY  ++++ + A   +LR+ C  R    +   G
Sbjct: 310 IVFWLG--YLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALG 357


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.138    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,231,467
Number of Sequences: 37866
Number of extensions: 691546
Number of successful extensions: 4718
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 320
Number of HSP's successfully gapped in prelim test: 251
Number of HSP's that attempted gapping in prelim test: 3802
Number of HSP's gapped (non-prelim): 859
length of query: 398
length of database: 18,247,518
effective HSP length: 104
effective length of query: 294
effective length of database: 14,309,454
effective search space: 4206979476
effective search space used: 4206979476
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.