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Search of human proteins with 6005902
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6005902 thrombospondin 3 precursor [Homo sapiens]
(956 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6005902 thrombospondin 3 precursor [Homo sapiens] 2034 0.0
gi|31543806 thrombospondin 4 precursor [Homo sapiens] 1224 0.0
gi|40217843 cartilage oligomeric matrix protein precursor [Homo ... 1046 0.0
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 740 0.0
gi|40317628 thrombospondin 2 precursor [Homo sapiens] 699 0.0
gi|126091152 cubilin [Homo sapiens] 101 4e-21
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 95 3e-19
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 95 3e-19
gi|34734066 fibulin 1 isoform D [Homo sapiens] 95 3e-19
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 95 3e-19
gi|24430141 fibrillin 1 precursor [Homo sapiens] 91 7e-18
gi|46249414 latent transforming growth factor beta binding prote... 87 6e-17
gi|46249412 latent transforming growth factor beta binding prote... 87 6e-17
gi|118572606 hemicentin 1 [Homo sapiens] 83 1e-15
gi|66346695 fibrillin 2 precursor [Homo sapiens] 82 2e-15
gi|24041035 notch 2 preproprotein [Homo sapiens] 79 2e-14
gi|110735443 delta-like 1 [Homo sapiens] 78 3e-14
gi|194328809 latent transforming growth factor beta binding prot... 78 5e-14
gi|18497288 latent transforming growth factor beta binding prote... 78 5e-14
gi|61743978 stabilin 1 precursor [Homo sapiens] 77 6e-14
gi|88758613 CD93 antigen precursor [Homo sapiens] 77 6e-14
gi|61743980 stabilin 2 precursor [Homo sapiens] 77 8e-14
gi|134244285 Notch homolog 3 [Homo sapiens] 77 1e-13
gi|10190748 CEGP1 protein [Homo sapiens] 77 1e-13
gi|56237021 fibrillin 3 precursor [Homo sapiens] 77 1e-13
gi|110347437 latent transforming growth factor beta binding prot... 77 1e-13
gi|110347412 latent transforming growth factor beta binding prot... 77 1e-13
gi|110347431 latent transforming growth factor beta binding prot... 77 1e-13
gi|148833508 notch1 preproprotein [Homo sapiens] 76 2e-13
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 75 2e-13
>gi|6005902 thrombospondin 3 precursor [Homo sapiens]
Length = 956
Score = 2034 bits (5270), Expect = 0.0
Identities = 956/956 (100%), Positives = 956/956 (100%)
Query: 1 METQELRGALALLLLCFFTSASQDLQVIDLLTVGESRQMVAVAEKIRTALLTAGDIYLLS 60
METQELRGALALLLLCFFTSASQDLQVIDLLTVGESRQMVAVAEKIRTALLTAGDIYLLS
Sbjct: 1 METQELRGALALLLLCFFTSASQDLQVIDLLTVGESRQMVAVAEKIRTALLTAGDIYLLS 60
Query: 61 TFRLPPKQGGVLFGLYSRQDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADG 120
TFRLPPKQGGVLFGLYSRQDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADG
Sbjct: 61 TFRLPPKQGGVLFGLYSRQDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADG 120
Query: 121 RTHTVLLRLRGPSRPSPALHLYVDCKLGDQHAGLPALAPIPPAEVDGLEIRTGQKAYLRM 180
RTHTVLLRLRGPSRPSPALHLYVDCKLGDQHAGLPALAPIPPAEVDGLEIRTGQKAYLRM
Sbjct: 121 RTHTVLLRLRGPSRPSPALHLYVDCKLGDQHAGLPALAPIPPAEVDGLEIRTGQKAYLRM 180
Query: 181 QGFVESMKIILGGSMARVGALSECPFQGDESIHSAVTNALHSILGEQTKALVTQLTLFNQ 240
QGFVESMKIILGGSMARVGALSECPFQGDESIHSAVTNALHSILGEQTKALVTQLTLFNQ
Sbjct: 181 QGFVESMKIILGGSMARVGALSECPFQGDESIHSAVTNALHSILGEQTKALVTQLTLFNQ 240
Query: 241 ILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRC 300
ILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRC
Sbjct: 241 ILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRC 300
Query: 301 GPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDY 360
GPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDY
Sbjct: 301 GPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDY 360
Query: 361 ARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHS 420
ARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHS
Sbjct: 361 ARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHS 420
Query: 421 PAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQ 480
PAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQ
Sbjct: 421 PAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQ 480
Query: 481 DNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACD 540
DNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACD
Sbjct: 481 DNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACD 540
Query: 541 NCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDS 600
NCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDS
Sbjct: 541 NCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDS 600
Query: 601 CPEMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECD 660
CPEMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECD
Sbjct: 601 CPEMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECD 660
Query: 661 GDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAE 720
GDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAE
Sbjct: 661 GDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAE 720
Query: 721 VTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGT 780
VTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGT
Sbjct: 721 VTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGT 780
Query: 781 FHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSG 840
FHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSG
Sbjct: 781 FHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSG 840
Query: 841 PGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQL 900
PGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQL
Sbjct: 841 PGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQL 900
Query: 901 VADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV 956
VADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV
Sbjct: 901 VADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV 956
>gi|31543806 thrombospondin 4 precursor [Homo sapiens]
Length = 961
Score = 1224 bits (3167), Expect = 0.0
Identities = 585/969 (60%), Positives = 703/969 (72%), Gaps = 44/969 (4%)
Query: 7 RGALALLLLCFF-----TSASQDLQVIDLLTVGESRQMVAVAEKIRTALLTAGDIYLLST 61
RGA LLL A QV DLL R + T D+Y++ST
Sbjct: 5 RGAAVLLLHLVLQRWLAAGAQATPQVFDLLPSSSQRLNPGALLPVLTDP-ALNDLYVIST 63
Query: 62 FRLPPKQGGVLFGLYSRQDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADGR 121
F+L K +FGLYS DN+++ E +V+G++NK ++RY + DGKVH V LADGR
Sbjct: 64 FKLQTKSSATIFGLYSSTDNSKYFEFTVMGRLNKAILRYLKNDGKVHLVVFNNLQLADGR 123
Query: 122 THTVLLRLRGPSRPSPALHLYVDCKLGDQHAGLPALAPIPPAEVDGLEIRTGQKAYLRMQ 181
H +LLRL R + +L LY+DC D LP P + + +E+RT Q+ + Q
Sbjct: 124 RHRILLRLSNLQRGAGSLELYLDCIQVDSVHNLPRAFAGPSQKPETIELRTFQR---KPQ 180
Query: 182 GFVESMKIILGGSMARVGALSECPFQGDESIHSAVTNALHSILGEQTKALVTQLTLFNQI 241
F+E +K+++ GS+ +V +L +C Q E + + T G+ + + Q+T NQ+
Sbjct: 181 DFLEELKLVVRGSLFQVASLQDCFLQQSEPLAATGT-------GDFNRQFLGQMTQLNQL 233
Query: 242 LVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRS--------------------HCSPN 281
L E++D +R QVKE S +RNTI ECQ CG + +S C N
Sbjct: 234 LGEVKDLLRQQVKETSFLRNTIAECQACGPLKFQSPTPSTVVPPAPPAPPTRPPRRCDSN 293
Query: 282 PCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHC 341
PCFRGV C + + G++CGPCP G GNG C D++EC + PC+PG CIN PGF C
Sbjct: 294 PCFRGVQCTDSRD--GFQCGPCPEGYTGNGITCIDVDECKY-HPCYPGVHCINLSPGFRC 350
Query: 342 EACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCR 401
+ACP G+ G V GVGI +A+++KQVC DIDEC NG C PNSIC NT+GS++CGPC+
Sbjct: 351 DACPVGFTGPMVQGVGISFAKSNKQVCTDIDECR---NGACVPNSICVNTLGSYRCGPCK 407
Query: 402 LGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDI 461
G+ G+Q +GC R C +P +PC ++A C+ ER G V+C C VGWAG+G +CG D DI
Sbjct: 408 PGYTGDQIRGCKAERNCRNPELNPCSVNAQCIEERQGDVTCVCGVGWAGDGYICGKDVDI 467
Query: 462 DGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRL 521
D YPD+ LPC N CK+DNC PNSGQEDAD DG+GD CD+DADGDGI N +DNC L
Sbjct: 468 DSYPDEELPCSARN--CKKDNCKYVPNSGQEDADRDGIGDACDEDADGDGILNEQDNCVL 525
Query: 522 FPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKV 581
N DQ+NSD D FGDACDNC +V NNDQKDTDG+G GDACD+D+DGDGI N LDNCPK
Sbjct: 526 IHNVDQRNSDKDIFGDACDNCLSVLNNDQKDTDGDGRGDACDDDMDGDGIKNILDNCPKF 585
Query: 582 PNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQ 641
PN Q D+D DGVGDACDSCP++SNP Q+D D+DLVGD CDTN+DSDGDGHQD+ DNCP
Sbjct: 586 PNRDQRDKDGDGVGDACDSCPDVSNPNQSDVDNDLVGDSCDTNQDSDGDGHQDSTDNCPT 645
Query: 642 LPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDGNGVGDVCED 701
+ NS+QLD+D DG+GDECD DDDNDGIPD VPPGPDNCRLVPNP Q+DS+ +GVGD+CE
Sbjct: 646 VINSAQLDTDKDGIGDECDDDDDNDGIPDLVPPGPDNCRLVPNPAQEDSNSDGVGDICES 705
Query: 702 DFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNS 761
DFD D V+D +DVCPE+AEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNS
Sbjct: 706 DFDQDQVIDRIDVCPENAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNS 765
Query: 762 DPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATP 821
DPGLAVGYTAFNGVDFEGTFHVNT TDDDYAGF+F YQDS FYVVMWKQTEQTYWQATP
Sbjct: 766 DPGLAVGYTAFNGVDFEGTFHVNTQTDDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQATP 825
Query: 822 FRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWQL 881
FRAVA+PG+QLKAV S +GPGEHLRN+LWHTG T DQVRLLW D RNVGW+DK SYRW L
Sbjct: 826 FRAVAEPGIQLKAVKSKTGPGEHLRNSLWHTGDTSDQVRLLWKDSRNVGWKDKVSYRWFL 885
Query: 882 LHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTVP 941
HRPQVGYIRV+ YEG +LVADSGV IDT+MRGGRLGVFCFSQENIIWSNL+YRCNDT+P
Sbjct: 886 QHRPQVGYIRVRFYEGSELVADSGVTIDTTMRGGRLGVFCFSQENIIWSNLKYRCNDTIP 945
Query: 942 EDFEPFRRQ 950
EDF+ F+ Q
Sbjct: 946 EDFQEFQTQ 954
>gi|40217843 cartilage oligomeric matrix protein precursor [Homo
sapiens]
Length = 757
Score = 1046 bits (2706), Expect = 0.0
Identities = 481/738 (65%), Positives = 572/738 (77%), Gaps = 25/738 (3%)
Query: 220 LHSILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRS--- 276
L S LG Q ++ +L N L ++R+ +R QV+E++ ++NT+MEC CG +
Sbjct: 26 LGSDLGPQ---MLRELQETNAALQDVRELLRQQVREITFLKNTVMECDACGMQQSVRTGL 82
Query: 277 -------HCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPG 329
HC+P CF GV C++ G RCGPCP G GNG+HC+D+NEC +A PCFP
Sbjct: 83 PSVRPLLHCAPGFCFPGVACIQTES--GARCGPCPAGFTGNGSHCTDVNEC-NAHPCFPR 139
Query: 330 SSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICT 389
CINT PGF CEACP GY G GVG+ +A+A+KQVC DI+EC G + C PNS+C
Sbjct: 140 VRCINTSPGFRCEACPPGYSGPTHQGVGLAFAKANKQVCTDINECETGQHN-CVPNSVCI 198
Query: 390 NTVGSFKCGPCRLGFLGNQSQGCL--PARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVG 447
NT GSF+CGPC+ GF+G+Q+ GC R C + S CH HA C+ ER+G+ SC C VG
Sbjct: 199 NTRGSFQCGPCQPGFVGDQASGCQRRAQRFCPDGSPSECHEHADCVLERDGSRSCVCAVG 258
Query: 448 WAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDA 507
WAGNG +CG DTD+DG+PD+ L C + + C++DNC+ PNSGQED D DG+GD CD DA
Sbjct: 259 WAGNGILCGRDTDLDGFPDEKLRCPE--RQCRKDNCVTVPNSGQEDVDRDGIGDACDPDA 316
Query: 508 DGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVD 567
DGDG+ N +DNC L N DQ+N+D D +GDACDNC + N+DQKDTD +G GDACD+D+D
Sbjct: 317 DGDGVPNEKDNCPLVRNPDQRNTDEDKWGDACDNCRSQKNDDQKDTDQDGRGDACDDDID 376
Query: 568 GDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCDTNEDS 627
GD I N DNCP+VPN Q D D DG+GDACD+CP+ SNP Q D D D VGD CD+++D
Sbjct: 377 GDRIRNQADNCPRVPNSDQKDSDGDGIGDACDNCPQKSNPDQADVDHDFVGDACDSDQDQ 436
Query: 628 DGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLVPNPNQ 687
DGDGHQD++DNCP +PNS+Q DSD+DG GD CD DDDNDG+PD DNCRLVPNP Q
Sbjct: 437 DGDGHQDSRDNCPTVPNSAQEDSDHDGQGDACDDDDDNDGVPD----SRDNCRLVPNPGQ 492
Query: 688 KDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWV 747
+D+D +GVGDVC+DDFD D VVD +DVCPE+AEVTLTDFRA+QTVVLDPEGDAQIDPNWV
Sbjct: 493 EDADRDGVGDVCQDDFDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWV 552
Query: 748 VLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVV 807
VLNQG EIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGF+F YQDS FYVV
Sbjct: 553 VLNQGREIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFIFGYQDSSSFYVV 612
Query: 808 MWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPR 867
MWKQ EQTYWQA PFRAVA+PG+QLKAV S +GPGE LRNALWHTG T QVRLLW DPR
Sbjct: 613 MWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTESQVRLLWKDPR 672
Query: 868 NVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENI 927
NVGW+DK SYRW L HRPQVGYIRV+ YEGP+LVADS V++DT+MRGGRLGVFCFSQENI
Sbjct: 673 NVGWKDKKSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTTMRGGRLGVFCFSQENI 732
Query: 928 IWSNLQYRCNDTVPEDFE 945
IW+NL+YRCNDT+PED+E
Sbjct: 733 IWANLRYRCNDTIPEDYE 750
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 740 bits (1910), Expect = 0.0
Identities = 356/682 (52%), Positives = 441/682 (64%), Gaps = 53/682 (7%)
Query: 263 IMECQVCGFHE-QRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECA 321
+ E Q+C + C NPCF GV C Y ++CG CPPG GNG C+D++EC
Sbjct: 535 VTENQICNKQDCPIDGCLSNPCFAGVKCTS-YPDGSWKCGACPPGYSGNGIQCTDVDECK 593
Query: 322 HA-DPCFPGSS---CINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDG 377
D CF + C NT PG++C CP + G+Q G G+++A A+KQVC + C DG
Sbjct: 594 EVPDACFNHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDG 653
Query: 378 NNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERN 437
+ C+ N+ C +LG+ S +
Sbjct: 654 TH-DCNKNAKC--------------NYLGHYS---------------------------D 671
Query: 438 GAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDN-NKHCKQDNCLLTPNSGQEDADN 496
C+C G+AGNG +CG DTD+DG+P++ L C+ N HCK+DNC PNSGQED D
Sbjct: 672 PMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDK 731
Query: 497 DGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGN 556
DG+GD CDDD D D I + DNC N Q + D D GD CDNCP N DQ DTD N
Sbjct: 732 DGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNN 791
Query: 557 GEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDL 616
GEGDAC D+DGDGI N DNC V N Q D D DGVGD CD+CP NP Q D+DSD
Sbjct: 792 GEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDR 851
Query: 617 VGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGP 676
+GD CD N+D D DGHQ+ DNCP +PN++Q D D DG GD CD DDDNDGIPD
Sbjct: 852 IGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPD----DK 907
Query: 677 DNCRLVPNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDP 736
DNCRLVPNP+QKDSDG+G GD C+DDFD+D+V D D+CPE+ +++ TDFR +Q + LDP
Sbjct: 908 DNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRFQMIPLDP 967
Query: 737 EGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLF 796
+G +Q DPNWVV +QG E+VQT+N DPGLAVGY FN VDF GTF +NT DDDYAGF+F
Sbjct: 968 KGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVF 1027
Query: 797 SYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTP 856
YQ S RFYVVMWKQ Q+YW P RA GL +K V S +GPGEHLRNALWHTG+TP
Sbjct: 1028 GYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTP 1087
Query: 857 DQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGR 916
QVR LW DPR++GW+D T+YRW+L HRP+ G+IRV +YEG +++ADSG I D + GGR
Sbjct: 1088 GQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAGGR 1147
Query: 917 LGVFCFSQENIIWSNLQYRCND 938
LG+F FSQE + +S+L+Y C D
Sbjct: 1148 LGLFVFSQEMVFFSDLKYECRD 1169
>gi|40317628 thrombospondin 2 precursor [Homo sapiens]
Length = 1172
Score = 699 bits (1804), Expect = 0.0
Identities = 349/690 (50%), Positives = 434/690 (62%), Gaps = 52/690 (7%)
Query: 270 GFHEQRSHC-SPNPCFRGVDCM-EVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCF 327
G E+ C SP P + G C+ +V E CP ++ C ++PCF
Sbjct: 513 GIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP------------VDGCL-SNPCF 559
Query: 328 PGSSCINTMPG-FHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNS 386
PG+ C + G + C +CP G+ G C D+DEC + +
Sbjct: 560 PGAQCSSFPDGSWSCGSCPVGFLGNGTH-------------CEDLDECALVPDICFSTSK 606
Query: 387 I--CTNTVGSFKCGPCRLGFLGNQSQG------------CLPARTCHSPAHSPCHIHAHC 432
+ C NT F C PC + GNQ G C P C H+ CH HA C
Sbjct: 607 VPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHN-CHKHAEC 665
Query: 433 LFERNGA---VSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDN-NKHCKQDNCLLTPN 488
++ + + C+C G+AG+G +CG D+D+DG+P+ L C N HC +DNC PN
Sbjct: 666 IYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPN 725
Query: 489 SGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNN 548
SGQED D DG+GD CDDD D DG+ + +DNC+L N Q + D D GD CDNCP V N
Sbjct: 726 SGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNP 785
Query: 549 DQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPT 608
Q DTD NGEGDAC D+DGD + N DNCP V N Q D D DGVGD CD+CP + NP
Sbjct: 786 AQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPD 845
Query: 609 QTDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGI 668
QTD D+DLVGD CD NED D DGHQ+ +DNCP + N++Q D D DG GD CD DDDNDG+
Sbjct: 846 QTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGV 905
Query: 669 PDYVPPGPDNCRLVPNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRA 728
PD DNCRLV NP+Q+D DG+G GD+C+DDFDND + D DVCPE+ ++ TDFR
Sbjct: 906 PD----DRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRN 961
Query: 729 YQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTD 788
+Q V LDP+G QIDPNWV+ +QG E+VQT NSDPG+AVG+ F VDF GTF+VNT D
Sbjct: 962 FQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRD 1021
Query: 789 DDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNA 848
DDYAGF+F YQ S RFYVVMWKQ QTYW+ P RA G+ LK V S +G GEHLRNA
Sbjct: 1022 DDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNA 1081
Query: 849 LWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQLVADSGVII 908
LWHTG+TP QVR LW DPRN+GW+D T+YRW L HRP+ GYIRV ++EG Q++ADSG I
Sbjct: 1082 LWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIY 1141
Query: 909 DTSMRGGRLGVFCFSQENIIWSNLQYRCND 938
D + GGRLG+F FSQE + +S+L+Y C D
Sbjct: 1142 DQTYAGGRLGLFVFSQEMVYFSDLKYECRD 1171
Score = 32.7 bits (73), Expect = 1.7
Identities = 34/160 (21%), Positives = 62/160 (38%), Gaps = 6/160 (3%)
Query: 45 KIRTALLTAGDIYLLSTFRLPPKQGGVLFGLYSRQDNTRWLEASVVGKINKVLVRYQRED 104
KI + +L + + K G L L + R E G + + + Y D
Sbjct: 73 KITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGPADTLDLTYWI-D 131
Query: 105 GKVHAVNLQQAGLADGRTHTVLLRLRGPSRPSPALHLYVDCKLGDQHAGLPALAPIPPAE 164
G H V+L+ GLAD + V +++ G + L+V C L D A AE
Sbjct: 132 GTRHVVSLEDVGLADSQWKNVTVQVAGET-----YSLHVGCDLIDSFALDEPFYEHLQAE 186
Query: 165 VDGLEIRTGQKAYLRMQGFVESMKIILGGSMARVGALSEC 204
+ + G +G ++++ ++ S+ + + C
Sbjct: 187 KSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGC 226
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 101 bits (251), Expect = 4e-21
Identities = 69/202 (34%), Positives = 95/202 (47%), Gaps = 34/202 (16%)
Query: 275 RSHCS--PNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHAD---PCFPG 329
R CS P PC V C + CG CP G QGNG C DINEC + P
Sbjct: 264 RDECSFQPGPCSTLVQCFNTQG--SFYCGACPTGWQGNGYICEDINECEINNGGCSVAPP 321
Query: 330 SSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICT 389
C+NT HC+ACP GY+G +VC D C+ +NGGC P++ C+
Sbjct: 322 VECVNTPGSSHCQACPPGYQG-------------DGRVCTLTDICS-VSNGGCHPDASCS 367
Query: 390 NTVGSFKCGPCRLGFLGN--QSQGCLP-ARTCHSPAHSPCHIHAHCLFERNGAVSCQCNV 446
+T+GS C G+ GN GC+ + C S PC ++ C+ +G C+C+
Sbjct: 368 STLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLS---HPC-LNGQCIDTVSG-YFCKCDS 422
Query: 447 GWAG-----NGNVCGTDTDIDG 463
GW G N N C ++ ++G
Sbjct: 423 GWTGVNCTENINECLSNPCLNG 444
Score = 68.6 bits (166), Expect = 3e-11
Identities = 73/248 (29%), Positives = 94/248 (37%), Gaps = 64/248 (25%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCS-DINECAHAD----PCFPGSSC 332
CS NPC G C+ +++ + C CPP Q G CS D+NEC C G +C
Sbjct: 136 CSSNPCQNGGTCLNLHD--SFFC-ICPP--QWKGPLCSADVNECEIYSGTPLSCQNGGTC 190
Query: 333 INTMPGFHCEACPRGYKGTQVSG-----VGIDYARASKQVCNDI---------------- 371
+NTM + C P Y G Q + G AR +C D+
Sbjct: 191 VNTMGSYSCHCPPETY-GPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDA 249
Query: 372 ---------------DECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPAR 416
DEC+ G C C NT GSF CG C G+ GN C
Sbjct: 250 GWMFSPNSPACTLDRDECS-FQPGPCSTLVQCFNTQGSFYCGACPTGWQGN-GYICEDIN 307
Query: 417 TCHSPAHSPCHI--HAHCLFERNGAVSCQ-CNVGWAGNGNVCGTDTDIDGYPDQALPCMD 473
C + C + C+ G+ CQ C G+ G+G VC T TDI C
Sbjct: 308 ECEI-NNGGCSVAPPVECV-NTPGSSHCQACPPGYQGDGRVC-TLTDI---------CSV 355
Query: 474 NNKHCKQD 481
+N C D
Sbjct: 356 SNGGCHPD 363
Score = 41.6 bits (96), Expect = 0.004
Identities = 36/121 (29%), Positives = 51/121 (42%), Gaps = 20/121 (16%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSD-INECAHADPCFPGSSCINTM 336
C +PC G C++ GY C C G G +C++ INEC ++PC G +C++ +
Sbjct: 399 CLSHPCLNG-QCIDTVS--GYFC-KCDSGW--TGVNCTENINECL-SNPCLNGGTCVDGV 451
Query: 337 PGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFK 396
F CE C R + G + +QVC E G NG S V
Sbjct: 452 DSFSCE-CTRLWTGA--------LCQVPQQVCG---ESLSGINGSFSYRSPDVGYVHDVN 499
Query: 397 C 397
C
Sbjct: 500 C 500
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 95.1 bits (235), Expect = 3e-19
Identities = 70/211 (33%), Positives = 93/211 (44%), Gaps = 30/211 (14%)
Query: 307 LQGNGTHCSDINEC-AHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASK 365
L +G C D+NEC + C G SCINT+ F C+ + S G Y
Sbjct: 207 LLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ---------RDSSCGTGYELTED 257
Query: 366 QVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGP---CRLGFLGNQSQGCLPARTCHSPA 422
C DIDEC G + C P+ IC NT+GSF+C P C+ GF+ + C+ C S
Sbjct: 258 NSCKDIDECESGIHN-CLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLS-I 315
Query: 423 HSPCHIHAHCLFERNGAVSCQCNVGWAGNG---NVCGTD-TDIDGYPDQALPCMDNNKHC 478
+PC I H G+ +CQ NV G G N GT D+D A PC
Sbjct: 316 SAPCPI-GHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC------G 368
Query: 479 KQDNCLLTPNSGQEDADN----DGVGDQCDD 505
K C+ +P S + + DG+ C D
Sbjct: 369 KGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/195 (29%), Positives = 82/195 (42%), Gaps = 37/195 (18%)
Query: 278 CSP--NPCFRGVDCMEVYEYPG-YRCGPCPPGLQGNGTH--CSDINECAHADPCFPGSSC 332
C+P PC +G C+ PG +RC C G +G C D+NEC G C
Sbjct: 360 CAPPAEPCGKGHRCVNS---PGSFRC-ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415
Query: 333 INTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTV 392
NT+ + C +C G++ V G + C DI+EC ++ C C N
Sbjct: 416 ENTLGSYLC-SCSVGFR-LSVDG----------RSCEDINEC---SSSPCSQE--CANVY 458
Query: 393 GSFKCGPCRLGFLGNQSQG--CLPARTCHSPAHSPCHIHAHCLFERNGAVSCQC-NVGW- 448
GS++C CR G+ + G C C P HI ++ G+ C C + G+
Sbjct: 459 GSYQC-YCRRGYQLSDVDGVTCEDIDECALPTGG--HICSYRCINIPGSFQCSCPSSGYR 515
Query: 449 -AGNGNVCGTDTDID 462
A NG C DID
Sbjct: 516 LAPNGRNC---QDID 527
Score = 52.0 bits (123), Expect = 3e-06
Identities = 42/129 (32%), Positives = 54/129 (41%), Gaps = 21/129 (16%)
Query: 273 EQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQ---GNGTHCSDINECAHADPCFPG 329
E + CS +PC + +C VY Y+C C G Q +G C DI+ECA
Sbjct: 440 EDINECSSSPCSQ--ECANVYG--SYQCY-CRRGYQLSDVDGVTCEDIDECALPTGGHIC 494
Query: 330 S-SCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSIC 388
S CIN F C GY+ + + C DIDEC G + C N C
Sbjct: 495 SYRCINIPGSFQCSCPSSGYR-----------LAPNGRNCQDIDECVTGIHN-CSINETC 542
Query: 389 TNTVGSFKC 397
N G F+C
Sbjct: 543 FNIQGGFRC 551
Score = 38.5 bits (88), Expect = 0.030
Identities = 29/80 (36%), Positives = 35/80 (43%), Gaps = 15/80 (18%)
Query: 297 GYRCGPCPPGLQGNGTHCSDINECAHA-DPCFPGSSCINTMPGFHCEA--CPRGYK---G 350
GYR P NG +C DI+EC C +C N GF C A CP Y+
Sbjct: 513 GYRLAP-------NGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAA 565
Query: 351 TQVSGVGIDY--ARASKQVC 368
TQ S G A +SK+ C
Sbjct: 566 TQKSKKGRQNTPAGSSKEDC 585
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 95.1 bits (235), Expect = 3e-19
Identities = 70/211 (33%), Positives = 93/211 (44%), Gaps = 30/211 (14%)
Query: 307 LQGNGTHCSDINEC-AHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASK 365
L +G C D+NEC + C G SCINT+ F C+ + S G Y
Sbjct: 207 LLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ---------RDSSCGTGYELTED 257
Query: 366 QVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGP---CRLGFLGNQSQGCLPARTCHSPA 422
C DIDEC G + C P+ IC NT+GSF+C P C+ GF+ + C+ C S
Sbjct: 258 NSCKDIDECESGIHN-CLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLS-I 315
Query: 423 HSPCHIHAHCLFERNGAVSCQCNVGWAGNG---NVCGTD-TDIDGYPDQALPCMDNNKHC 478
+PC I H G+ +CQ NV G G N GT D+D A PC
Sbjct: 316 SAPCPI-GHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC------G 368
Query: 479 KQDNCLLTPNSGQEDADN----DGVGDQCDD 505
K C+ +P S + + DG+ C D
Sbjct: 369 KGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/195 (29%), Positives = 82/195 (42%), Gaps = 37/195 (18%)
Query: 278 CSP--NPCFRGVDCMEVYEYPG-YRCGPCPPGLQGNGTH--CSDINECAHADPCFPGSSC 332
C+P PC +G C+ PG +RC C G +G C D+NEC G C
Sbjct: 360 CAPPAEPCGKGHRCVNS---PGSFRC-ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415
Query: 333 INTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTV 392
NT+ + C +C G++ V G + C DI+EC ++ C C N
Sbjct: 416 ENTLGSYLC-SCSVGFR-LSVDG----------RSCEDINEC---SSSPCSQE--CANVY 458
Query: 393 GSFKCGPCRLGFLGNQSQG--CLPARTCHSPAHSPCHIHAHCLFERNGAVSCQC-NVGW- 448
GS++C CR G+ + G C C P HI ++ G+ C C + G+
Sbjct: 459 GSYQC-YCRRGYQLSDVDGVTCEDIDECALPTGG--HICSYRCINIPGSFQCSCPSSGYR 515
Query: 449 -AGNGNVCGTDTDID 462
A NG C DID
Sbjct: 516 LAPNGRNC---QDID 527
Score = 52.0 bits (123), Expect = 3e-06
Identities = 42/129 (32%), Positives = 54/129 (41%), Gaps = 21/129 (16%)
Query: 273 EQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQ---GNGTHCSDINECAHADPCFPG 329
E + CS +PC + +C VY Y+C C G Q +G C DI+ECA
Sbjct: 440 EDINECSSSPCSQ--ECANVYG--SYQCY-CRRGYQLSDVDGVTCEDIDECALPTGGHIC 494
Query: 330 S-SCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSIC 388
S CIN F C GY+ + + C DIDEC G + C N C
Sbjct: 495 SYRCINIPGSFQCSCPSSGYR-----------LAPNGRNCQDIDECVTGIHN-CSINETC 542
Query: 389 TNTVGSFKC 397
N G F+C
Sbjct: 543 FNIQGGFRC 551
Score = 37.7 bits (86), Expect = 0.052
Identities = 21/56 (37%), Positives = 25/56 (44%), Gaps = 10/56 (17%)
Query: 297 GYRCGPCPPGLQGNGTHCSDINECAHA-DPCFPGSSCINTMPGFHCEA--CPRGYK 349
GYR P NG +C DI+EC C +C N GF C A CP Y+
Sbjct: 513 GYRLAP-------NGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 95.1 bits (235), Expect = 3e-19
Identities = 70/211 (33%), Positives = 93/211 (44%), Gaps = 30/211 (14%)
Query: 307 LQGNGTHCSDINEC-AHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASK 365
L +G C D+NEC + C G SCINT+ F C+ + S G Y
Sbjct: 207 LLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ---------RDSSCGTGYELTED 257
Query: 366 QVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGP---CRLGFLGNQSQGCLPARTCHSPA 422
C DIDEC G + C P+ IC NT+GSF+C P C+ GF+ + C+ C S
Sbjct: 258 NSCKDIDECESGIHN-CLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLS-I 315
Query: 423 HSPCHIHAHCLFERNGAVSCQCNVGWAGNG---NVCGTD-TDIDGYPDQALPCMDNNKHC 478
+PC I H G+ +CQ NV G G N GT D+D A PC
Sbjct: 316 SAPCPI-GHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC------G 368
Query: 479 KQDNCLLTPNSGQEDADN----DGVGDQCDD 505
K C+ +P S + + DG+ C D
Sbjct: 369 KGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/195 (29%), Positives = 82/195 (42%), Gaps = 37/195 (18%)
Query: 278 CSP--NPCFRGVDCMEVYEYPG-YRCGPCPPGLQGNGTH--CSDINECAHADPCFPGSSC 332
C+P PC +G C+ PG +RC C G +G C D+NEC G C
Sbjct: 360 CAPPAEPCGKGHRCVNS---PGSFRC-ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415
Query: 333 INTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTV 392
NT+ + C +C G++ V G + C DI+EC ++ C C N
Sbjct: 416 ENTLGSYLC-SCSVGFR-LSVDG----------RSCEDINEC---SSSPCSQE--CANVY 458
Query: 393 GSFKCGPCRLGFLGNQSQG--CLPARTCHSPAHSPCHIHAHCLFERNGAVSCQC-NVGW- 448
GS++C CR G+ + G C C P HI ++ G+ C C + G+
Sbjct: 459 GSYQC-YCRRGYQLSDVDGVTCEDIDECALPTGG--HICSYRCINIPGSFQCSCPSSGYR 515
Query: 449 -AGNGNVCGTDTDID 462
A NG C DID
Sbjct: 516 LAPNGRNC---QDID 527
Score = 52.0 bits (123), Expect = 3e-06
Identities = 42/129 (32%), Positives = 54/129 (41%), Gaps = 21/129 (16%)
Query: 273 EQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQ---GNGTHCSDINECAHADPCFPG 329
E + CS +PC + +C VY Y+C C G Q +G C DI+ECA
Sbjct: 440 EDINECSSSPCSQ--ECANVYG--SYQCY-CRRGYQLSDVDGVTCEDIDECALPTGGHIC 494
Query: 330 S-SCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSIC 388
S CIN F C GY+ + + C DIDEC G + C N C
Sbjct: 495 SYRCINIPGSFQCSCPSSGYR-----------LAPNGRNCQDIDECVTGIHN-CSINETC 542
Query: 389 TNTVGSFKC 397
N G F+C
Sbjct: 543 FNIQGGFRC 551
Score = 37.7 bits (86), Expect = 0.052
Identities = 21/56 (37%), Positives = 25/56 (44%), Gaps = 10/56 (17%)
Query: 297 GYRCGPCPPGLQGNGTHCSDINECAHA-DPCFPGSSCINTMPGFHCEA--CPRGYK 349
GYR P NG +C DI+EC C +C N GF C A CP Y+
Sbjct: 513 GYRLAP-------NGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 95.1 bits (235), Expect = 3e-19
Identities = 70/211 (33%), Positives = 93/211 (44%), Gaps = 30/211 (14%)
Query: 307 LQGNGTHCSDINEC-AHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASK 365
L +G C D+NEC + C G SCINT+ F C+ + S G Y
Sbjct: 207 LLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQ---------RDSSCGTGYELTED 257
Query: 366 QVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGP---CRLGFLGNQSQGCLPARTCHSPA 422
C DIDEC G + C P+ IC NT+GSF+C P C+ GF+ + C+ C S
Sbjct: 258 NSCKDIDECESGIHN-CLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLS-I 315
Query: 423 HSPCHIHAHCLFERNGAVSCQCNVGWAGNG---NVCGTD-TDIDGYPDQALPCMDNNKHC 478
+PC I H G+ +CQ NV G G N GT D+D A PC
Sbjct: 316 SAPCPI-GHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC------G 368
Query: 479 KQDNCLLTPNSGQEDADN----DGVGDQCDD 505
K C+ +P S + + DG+ C D
Sbjct: 369 KGHRCVNSPGSFRCECKTGYYFDGISRMCVD 399
Score = 54.3 bits (129), Expect = 5e-07
Identities = 50/164 (30%), Positives = 65/164 (39%), Gaps = 28/164 (17%)
Query: 273 EQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQ---GNGTHCSDINECAHADPCFPG 329
E + CS +PC + +C VY Y+C C G Q +G C DI+ECA
Sbjct: 440 EDINECSSSPCSQ--ECANVYG--SYQCY-CRRGYQLSDVDGVTCEDIDECALPTGGHIC 494
Query: 330 S-SCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSIC 388
S CIN F C GY+ + + C DIDEC G + C N C
Sbjct: 495 SYRCINIPGSFQCSCPSSGYR-----------LAPNGRNCQDIDECVTGIHN-CSINETC 542
Query: 389 TNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHC 432
N G F+C L F ++ A C PCH + C
Sbjct: 543 FNIQGGFRC----LAFECPENYRRSAATRCE---RLPCHENREC 579
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/195 (29%), Positives = 82/195 (42%), Gaps = 37/195 (18%)
Query: 278 CSP--NPCFRGVDCMEVYEYPG-YRCGPCPPGLQGNGTH--CSDINECAHADPCFPGSSC 332
C+P PC +G C+ PG +RC C G +G C D+NEC G C
Sbjct: 360 CAPPAEPCGKGHRCVNS---PGSFRC-ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415
Query: 333 INTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTV 392
NT+ + C +C G++ V G + C DI+EC ++ C C N
Sbjct: 416 ENTLGSYLC-SCSVGFR-LSVDG----------RSCEDINEC---SSSPCSQE--CANVY 458
Query: 393 GSFKCGPCRLGFLGNQSQG--CLPARTCHSPAHSPCHIHAHCLFERNGAVSCQC-NVGW- 448
GS++C CR G+ + G C C P HI ++ G+ C C + G+
Sbjct: 459 GSYQC-YCRRGYQLSDVDGVTCEDIDECALPTGG--HICSYRCINIPGSFQCSCPSSGYR 515
Query: 449 -AGNGNVCGTDTDID 462
A NG C DID
Sbjct: 516 LAPNGRNC---QDID 527
Score = 40.0 bits (92), Expect = 0.010
Identities = 25/82 (30%), Positives = 35/82 (42%), Gaps = 17/82 (20%)
Query: 297 GYRCGPCPPGLQGNGTHCSDINECAHA-DPCFPGSSCINTMPGFHCEA--CPRGYKGTQV 353
GYR P NG +C DI+EC C +C N GF C A CP Y+ +
Sbjct: 513 GYRLAP-------NGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAA 565
Query: 354 SGVGIDYARASKQVCNDIDECN 375
+ R + C++ EC+
Sbjct: 566 T-------RCERLPCHENRECS 580
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 90.5 bits (223), Expect = 7e-18
Identities = 81/250 (32%), Positives = 109/250 (43%), Gaps = 44/250 (17%)
Query: 279 SPNPCFRGVDCMEVYEYPG-YRCGPCPPGLQGNGTH--CSDINEC-AHADPCFPGSSCIN 334
+PN C G C + PG YRC C G + C D+NEC + + C G+ C N
Sbjct: 1245 NPNICDGG-QCTNI---PGEYRC-LCYDGFMASEDMKTCVDVNECDLNPNICLSGT-CEN 1298
Query: 335 TMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGS 394
T F C C GY G + K C DI+EC G + C +++CTNT GS
Sbjct: 1299 TKGSFICH-CDMGYSG-----------KKGKTGCTDINECEIGAHN-CGKHAVCTNTAGS 1345
Query: 395 FKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNV 454
FKC C G++G+ + C C + H C HA C G+ C C G+ G+G
Sbjct: 1346 FKCS-CSPGWIGDGIK-CTDLDECSNGTHM-CSQHADCK-NTMGSYRCLCKEGYTGDGFT 1401
Query: 455 CGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKN 514
C TD+D C +N C CL P + + D V ADG ++
Sbjct: 1402 C---TDLD-------ECSENLNLCGNGQCLNAPGGYRCECDMGFV-----PSADGKACED 1446
Query: 515 VEDNCRLFPN 524
+ D C L PN
Sbjct: 1447 I-DECSL-PN 1454
Score = 78.2 bits (191), Expect = 3e-14
Identities = 103/415 (24%), Positives = 150/415 (36%), Gaps = 88/415 (21%)
Query: 265 ECQVCGFHEQR-------SHCSPNP-CFRGVDCMEVYEYPGYRCGPCPPGLQGNGT-HCS 315
EC V F+ + C P C R +C+ YRC C PG + T C+
Sbjct: 1792 ECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAG--SYRCD-CKPGYRFTSTGQCN 1848
Query: 316 DINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECN 375
D NEC CI+T+ F+C C G+K + +C DI+EC
Sbjct: 1849 DRNECQEIPNICSHGQCIDTVGSFYC-LCHTGFKTND-----------DQTMCLDINECE 1896
Query: 376 DGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFE 435
G N C NT+GSF C C GF+ + + C+ C S + C + C+
Sbjct: 1897 RDACG----NGTCRNTIGSFNCR-CNHGFILSHNNDCIDVDECASGNGNLCR-NGQCI-N 1949
Query: 436 RNGAVSCQCNVGW--AGNGNVC---------------GTDTDIDGY------PDQALP-- 470
G+ CQCN G+ A +G C GT ++DG P +L
Sbjct: 1950 TVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNE 2009
Query: 471 -------CMDNNKHCKQDNCLLTPNSGQ----EDADNDGVGDQCDD------DADGDGIK 513
C++ + C C T S + E G +C D A +G K
Sbjct: 2010 KCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGK 2069
Query: 514 NVEDNCRLFPNKDQQNS----DTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGD 569
R N +Q + +GD C+ CP P+ + G G V D
Sbjct: 2070 CSSPKSR---NHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGII----VGPD 2122
Query: 570 GIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCP---EMSNPTQTDADSDLVGDVC 621
+D C K P+ + + + G CP ++ D D VG+ C
Sbjct: 2123 DSAVDMDEC-KEPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGNPC 2176
Score = 72.8 bits (177), Expect = 1e-12
Identities = 53/175 (30%), Positives = 78/175 (44%), Gaps = 23/175 (13%)
Query: 281 NPCFRGVDCMEVYEYPGYRCGPCPPGLQ-GNGTHCSDINECAHADPCFPGSSCINTMPGF 339
NPC G C V G+ C C G + G C DINECA +P C+NT +
Sbjct: 2174 NPCGNGT-CKNVIG--GFEC-TCEEGFEPGPMMTCEDINECAQ-NPLLCAFRCVNTYGSY 2228
Query: 340 HCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGP 399
C+ CP GY R +++C D DEC +G + + C N +G++ C
Sbjct: 2229 ECK-CPVGY-----------VLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMC-I 2275
Query: 400 CRLGFLGN-QSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGN 453
C G+ +GC+ C + C + CL R G+ +C+CN G+ + N
Sbjct: 2276 CGPGYQRRPDGEGCVDENECQTKP-GICE-NGRCLNTR-GSYTCECNDGFTASPN 2327
Score = 67.4 bits (163), Expect = 6e-11
Identities = 58/183 (31%), Positives = 75/183 (40%), Gaps = 29/183 (15%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGN--GTHCSDINECAHADPCFPGSSCINT 335
C NPC G +C+ Y C C G Q T C DI+EC CINT
Sbjct: 494 CEKNPCAGG-ECIN--NQGSYTC-QCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINT 549
Query: 336 MPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSF 395
FHC V G R K C D+DEC+ N N +C N GSF
Sbjct: 550 DGSFHC-----------VCNAGFHVTRDGKN-CEDMDECSIRN---MCLNGMCINEDGSF 594
Query: 396 KCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAG--NG 452
KC C+ GF L + + C C +P ++ C+ +G+ C+C G A +G
Sbjct: 595 KC-ICKPGFQLASDGRYCKDINECETPG---ICMNGRCV-NTDGSYRCECFPGLAVGLDG 649
Query: 453 NVC 455
VC
Sbjct: 650 RVC 652
Score = 67.0 bits (162), Expect = 8e-11
Identities = 43/109 (39%), Positives = 56/109 (51%), Gaps = 19/109 (17%)
Query: 298 YRCGPCPPG--LQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSG 355
YRC CPPG L N + C DINEC + P C+N + + C AC GY T
Sbjct: 1136 YRC-ECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQC-ACNPGYHST---- 1189
Query: 356 VGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF 404
+ C DIDEC+ NGGC+ + CTN+ GS++C C+ GF
Sbjct: 1190 -------PDRLFCVDIDECSI-MNGGCE--TFCTNSEGSYECS-CQPGF 1227
Score = 65.1 bits (157), Expect = 3e-10
Identities = 80/321 (24%), Positives = 117/321 (36%), Gaps = 61/321 (19%)
Query: 283 CFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCE 342
C + DC YRC C G G+G C+D++EC+ C+N G+ CE
Sbjct: 1374 CSQHADCKNTMG--SYRC-LCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCE 1430
Query: 343 ACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRL 402
C G+ A + C DIDEC+ N C N G F+C C +
Sbjct: 1431 -CDMGF-----------VPSADGKACEDIDECSLPN---ICVFGTCHNLPGLFRC-ECEI 1474
Query: 403 GFLGNQSQG-CLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDI 461
G+ ++S G C C P + C I +C+ G+ C C + N G
Sbjct: 1475 GYELDRSGGNCTDVNECLDP--TTC-ISGNCV-NTPGSYICDCPPDFELNPTRVG----- 1525
Query: 462 DGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRL 521
C+D + NC L + DN GD + G G+ C L
Sbjct: 1526 ---------CVDT----RSGNCYL---DIRPRGDN---GDTACSNEIGVGVSKASCCCSL 1566
Query: 522 FPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKV 581
++G C+ CP V ++ K GEG N + I +D C ++
Sbjct: 1567 ----------GKAWGTPCEMCPAVNTSEYKILCPGGEGFR-PNPI--TVILEDIDECQEL 1613
Query: 582 PNPLQTDRDEDGVGDACDSCP 602
P Q + + G CP
Sbjct: 1614 PGLCQGGKCINTFGSFQCRCP 1634
Score = 63.5 bits (153), Expect = 9e-10
Identities = 48/168 (28%), Positives = 69/168 (41%), Gaps = 33/168 (19%)
Query: 316 DINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECN 375
DI+EC CIN + F CE CP G+ + VC DIDEC
Sbjct: 1766 DIDECREIPGVCENGVCINMVGSFRCE-CPVGF-----------FYNDKLLVCEDIDECQ 1813
Query: 376 DGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFE 435
+G C N+ C NT GS++C C+ G+ + C C + C H C+ +
Sbjct: 1814 NG--PVCQRNAECINTAGSYRC-DCKPGYRFTSTGQCNDRNECQE-IPNICS-HGQCI-D 1867
Query: 436 RNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNC 483
G+ C C+ G+ N D C+D N+ C++D C
Sbjct: 1868 TVGSFYCLCHTGFKTN--------------DDQTMCLDINE-CERDAC 1900
Score = 60.8 bits (146), Expect = 6e-09
Identities = 48/154 (31%), Positives = 67/154 (43%), Gaps = 33/154 (21%)
Query: 262 TIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCP-----------PGLQGN 310
T++ Q+C + S C + + C V G+ C CP P ++
Sbjct: 188 TVISNQMC-----QGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTG 242
Query: 311 GTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCND 370
C D++EC G +CINT+ F C+ CP G+K +VS Q C D
Sbjct: 243 A--CQDVDECQAIPGLCQGGNCINTVGSFECK-CPAGHKLNEVS-----------QKCED 288
Query: 371 IDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF 404
IDEC+ G C+ CTNTV S+ C C GF
Sbjct: 289 IDECST-IPGICEGGE-CTNTVSSYFC-KCPPGF 319
Score = 58.2 bits (139), Expect = 4e-08
Identities = 57/230 (24%), Positives = 86/230 (37%), Gaps = 49/230 (21%)
Query: 303 CPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYAR 362
CP G +G T+ +DI+EC C+N +HC C GY ++G
Sbjct: 2390 CPHG-RGFMTNGADIDECKVIHDVCRNGECVNDRGSYHC-ICKTGYT-PDITGTS----- 2441
Query: 363 ASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTCHSP 421
C D++ECN C N IC NT GS++C C G+ L + C C +
Sbjct: 2442 -----CVDLNECNQAPKP-C--NFICKNTEGSYQCS-CPKGYILQEDGRSCKDLDECATK 2492
Query: 422 AHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQD 481
H+ + + + G +C+C G+ C+DNN+
Sbjct: 2493 QHNCQFLCVNTI----GGFTCKCP----------------PGFTQHHTSCIDNNECTSDI 2532
Query: 482 N-------CLLTPNS----GQEDADNDGVGDQCDDDADGDGIKNVEDNCR 520
N C TP S Q D G C+D + +G + C+
Sbjct: 2533 NLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQ 2582
Score = 56.6 bits (135), Expect = 1e-07
Identities = 58/192 (30%), Positives = 74/192 (38%), Gaps = 59/192 (30%)
Query: 297 GYRCGPCPPGLQGNGTHCSDINEC-AHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSG 355
G+ C CPPG + T C D NEC + + C C NT F CE C RG+
Sbjct: 2506 GFTC-KCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCE-CQRGFS------ 2557
Query: 356 VGIDYARASKQVCNDIDECNDGNNG---GC-------------------------DPNSI 387
+D +S C D+DEC +GN+ GC D N
Sbjct: 2558 --LDQTGSS---CEDVDEC-EGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENEC 2611
Query: 388 ----------CTNTVGSFKCGPCRLGFLGNQ-SQGCLPARTCHSPAHSPCHIHAHCLFER 436
C NT+GS+KC C GF Q S GC C S A +PC ++
Sbjct: 2612 LSAHICGGASCHNTLGSYKC-MCPAGFQYEQFSGGCQDINECGS-AQAPC---SYGCSNT 2666
Query: 437 NGAVSCQCNVGW 448
G C C G+
Sbjct: 2667 EGGYLCGCPPGY 2678
Score = 55.5 bits (132), Expect = 2e-07
Identities = 91/399 (22%), Positives = 141/399 (35%), Gaps = 58/399 (14%)
Query: 298 YRCGPCPPGLQ--GNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSG 355
Y+C C G + G +C DINEC C NT F C CP+G+
Sbjct: 746 YKC-ICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVC-TCPKGF------- 796
Query: 356 VGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPA 415
+ + C DIDEC + C N +C N+ GSF C L C+
Sbjct: 797 ----IYKPDLKTCEDIDEC---ESSPC-INGVCKNSPGSFICECSSESTLDPTKTICIET 848
Query: 416 --RTCHSPAHSPCHIHAHCLFERNGA-VSCQC----NVGWAGNGNVCGTDTDI-DGYPD- 466
TC I C NGA + QC W +C D GY
Sbjct: 849 IKGTCWQTV-----IDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRI 903
Query: 467 QALPCMDNNK------HCKQDNCLLTPNSGQEDADN----DGVGDQC-DDDADGDGIKNV 515
+ C D ++ CK C+ T S + + D G C D + ++
Sbjct: 904 KGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYE 963
Query: 516 EDNCRL-FPNKDQQNSDTDSFGDA-----CDNCPNVPNNDQKDTDGNGEGDACDNDVDGD 569
++ C L + + ++ S G A C+ CP + ++ G G A +G
Sbjct: 964 DEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGK 1023
Query: 570 GIPNGLDNCPKVPNPLQTDRDEDGVGD---ACDSCPEMSNPTQTDADSD---LVGDVCDT 623
++ C +P+ + + +G CDS + + + D D + D+C
Sbjct: 1024 PFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGR 1083
Query: 624 NEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGD 662
+ + G D + C + S + N DEC D
Sbjct: 1084 GQCVNTPG--DFECKCDEGYESGFMMMKNCMDIDECQRD 1120
Score = 53.5 bits (127), Expect = 9e-07
Identities = 30/82 (36%), Positives = 38/82 (46%), Gaps = 15/82 (18%)
Query: 316 DINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECN 375
DI+EC G CINT F C CP GY Y +VC+D++EC
Sbjct: 1606 DIDECQELPGLCQGGKCINTFGSFQCR-CPTGY-----------YLNEDTRVCDDVNECE 1653
Query: 376 DGNNGGCDPNSICTNTVGSFKC 397
G C P + C NTVG++ C
Sbjct: 1654 --TPGICGPGT-CYNTVGNYTC 1672
Score = 50.8 bits (120), Expect = 6e-06
Identities = 58/216 (26%), Positives = 80/216 (37%), Gaps = 41/216 (18%)
Query: 279 SPNPCFRGVDCMEVYEYPG-YRCGPCPPGLQGNGT---HCSDINECAHADPCFPGSSCIN 334
SP+ C RG C+ PG + C C G + +C DI+EC G C N
Sbjct: 1077 SPDLCGRG-QCVNT---PGDFEC-KCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHN 1131
Query: 335 TMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGS 394
T + CE CP G++ + C DI+EC + PN C N +G
Sbjct: 1132 TEGSYRCE-CPPGHQ-----------LSPNISACIDINECE--LSAHLCPNGRCVNLIGK 1177
Query: 395 FKCGPCRLGFLGNQSQ-GCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWA--GN 451
++C C G+ + C+ C S + C G+ C C G+A +
Sbjct: 1178 YQCA-CNPGYHSTPDRLFCVDIDEC-SIMNGGCETFC---TNSEGSYECSCQPGFALMPD 1232
Query: 452 GNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTP 487
C TDID C DN C C P
Sbjct: 1233 QRSC---TDID-------ECEDNPNICDGGQCTNIP 1258
Score = 50.1 bits (118), Expect = 1e-05
Identities = 44/147 (29%), Positives = 59/147 (40%), Gaps = 26/147 (17%)
Query: 307 LQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQ 366
L +C+DI+EC + C+NT F C+ C GY+ SG +
Sbjct: 1061 LDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECK-CDEGYE----SGF------MMMK 1109
Query: 367 VCNDIDECNDGNNGGCDP----NSICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTCHSP 421
C DIDEC DP +C NT GS++C C G L C+ C
Sbjct: 1110 NCMDIDECQR------DPLLCRGGVCHNTEGSYRC-ECPPGHQLSPNISACIDINECELS 1162
Query: 422 AHSPCHIHAHCLFERNGAVSCQCNVGW 448
AH C + C+ G C CN G+
Sbjct: 1163 AHL-CP-NGRCV-NLIGKYQCACNPGY 1186
Score = 42.0 bits (97), Expect = 0.003
Identities = 53/216 (24%), Positives = 71/216 (32%), Gaps = 73/216 (33%)
Query: 270 GFH--------EQRSHCS-PNPCFRGVDCMEVYEYPGYRCGPCPPGLQ--GNGTHCSDIN 318
GFH E CS N C G M + E ++C C PG Q +G +C DIN
Sbjct: 560 GFHVTRDGKNCEDMDECSIRNMCLNG---MCINEDGSFKC-ICKPGFQLASDGRYCKDIN 615
Query: 319 ECAHADPCFPGSSCINTMPGFHCEA---------------------CPRGYKGTQVSGVG 357
EC C G C+NT + CE C GYK Q
Sbjct: 616 ECETPGICMNGR-CVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPL 674
Query: 358 IDYARASKQVCNDIDE--------------------CNDG---NNGGCD----------- 383
S+ C + C+ G + G D
Sbjct: 675 FGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDIC 734
Query: 384 PNSICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTC 418
PN IC N G++KC C G+ + + + C+ C
Sbjct: 735 PNGICENLRGTYKC-ICNSGYEVDSTGKNCVDINEC 769
Score = 36.2 bits (82), Expect = 0.15
Identities = 31/102 (30%), Positives = 44/102 (43%), Gaps = 20/102 (19%)
Query: 256 MSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPG--LQGNGTH 313
+++I I ECQ E C C + + ++C CP G L +
Sbjct: 1600 ITVILEDIDECQ-----ELPGLCQGGKC--------INTFGSFQCR-CPTGYYLNEDTRV 1645
Query: 314 CSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSG 355
C D+NEC C PG +C NT+ + C CP Y QV+G
Sbjct: 1646 CDDVNECETPGICGPG-TCYNTVGNYTC-ICPPDY--MQVNG 1683
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 87.4 bits (215), Expect = 6e-17
Identities = 77/252 (30%), Positives = 97/252 (38%), Gaps = 46/252 (18%)
Query: 283 CFRGVDCMEVYEYPGYRCGPCPPGLQ-GNGTHCSDINECAHADPCFPGSSCINTMPGFHC 341
C RG DC+ Y C CP G Q + C DINEC H C P C+NT FHC
Sbjct: 1173 CQRG-DCINTAG--SYDC-TCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHC 1228
Query: 342 EACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCR 401
C +G+ A + C DIDEC NN CD + C NT GSF+C C
Sbjct: 1229 -VCQQGFS-----------ISADGRTCEDIDEC--VNNTVCDSHGFCDNTAGSFRC-LCY 1273
Query: 402 LGFLGNQ-SQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQC---------NVGWAGN 451
GF Q QGC+ C S A C G+ C C G +
Sbjct: 1274 QGFQAPQDGQGCVDVNECE--LLSGVCGEAFC-ENVEGSFLCVCADENQEYSPMTGQCRS 1330
Query: 452 GNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDG 511
D D+D ++ C N + +L PN +++ C G G
Sbjct: 1331 RTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQEC--------CCTSGAGWG 1382
Query: 512 IKNVEDNCRLFP 523
DNC +FP
Sbjct: 1383 -----DNCEIFP 1389
Score = 80.9 bits (198), Expect = 5e-15
Identities = 84/329 (25%), Positives = 121/329 (36%), Gaps = 65/329 (19%)
Query: 261 NTI--MECQVC--GFH-EQRSHCSP-NPCFRGVDCME--VYEYPG-YRCGPCPPGLQGNG 311
NT+ C+ C G+ QR C + C C + PG Y+C PC G +G
Sbjct: 975 NTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWN 1034
Query: 312 THCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDI 371
C D++EC + C G C N + C +C +GY T + C DI
Sbjct: 1035 GQCLDVDECLEPNVCANG-DCSNLEGSYMC-SCHKGYTRT-----------PDHKHCRDI 1081
Query: 372 DECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTC---HSPAHSPCH 427
DEC GN N C NT GSF+C C G+ L C C H AH C
Sbjct: 1082 DECQQGN---LCVNGQCKNTEGSFRC-TCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCR 1137
Query: 428 IHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTP 487
G+ C C+ G+ +G + + + C+++ C++ +C+ T
Sbjct: 1138 -------NTEGSFQCVCDQGYRASG--------LGDHCEDINECLEDKSVCQRGDCINTA 1182
Query: 488 NSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKD------------QQNSDTDSF 535
S + G Q DD+ I E P + QQ +
Sbjct: 1183 GSYDCTCPD---GFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISAD 1239
Query: 536 GDACDNCPNVPNNDQKDTDGNGEGDACDN 564
G C++ NN D+ G CDN
Sbjct: 1240 GRTCEDIDECVNNTVCDSHG-----FCDN 1263
Score = 73.9 bits (180), Expect = 7e-13
Identities = 91/366 (24%), Positives = 127/366 (34%), Gaps = 65/366 (17%)
Query: 265 ECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHAD 324
+C+ + R C+ C + GYR G G HC DINEC
Sbjct: 1118 QCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRAS-------GLGDHCEDINECLEDK 1170
Query: 325 PCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDP 384
CINT + C CP G++ +D + C DI+EC + G C P
Sbjct: 1171 SVCQRGDCINTAGSYDC-TCPDGFQ--------LD----DNKTCQDINECE--HPGLCGP 1215
Query: 385 NSICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQ 443
C NT GSF C C+ GF + + C C + ++ C H C G+ C
Sbjct: 1216 QGECLNTEGSFHC-VCQQGFSISADGRTCEDIDECVN--NTVCDSHGFC-DNTAGSFRCL 1271
Query: 444 CNVGWAG--NGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGD 501
C G+ +G C +D + L + C+ E+ + +
Sbjct: 1272 CYQGFQAPQDGQGC-----VDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTG 1326
Query: 502 QC------DDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDN--CPNVPNNDQKDT 553
QC D D D D K + C N CDN PNV + T
Sbjct: 1327 QCRSRTSTDLDVDVDQPKEEKKECYYNLND----------ASLCDNVLAPNVTKQECCCT 1376
Query: 554 DGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVG--DACDSCPEMSNPTQTD 611
G G GD C+ + CP + T+ G G A +S E D
Sbjct: 1377 SGAGWGDNCE-----------IFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKD 1425
Query: 612 ADSDLV 617
AD L+
Sbjct: 1426 ADECLL 1431
Score = 52.4 bits (124), Expect = 2e-06
Identities = 59/225 (26%), Positives = 76/225 (33%), Gaps = 49/225 (21%)
Query: 263 IMECQV----CGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDIN 318
I EC V CG HC P C Y GYR C DI+
Sbjct: 875 INECTVNPDICG----AGHCINLPVRYTCIC-----YEGYR-------FSEQQRKCVDID 918
Query: 319 ECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGN 378
EC C NT F C CP G+ ++ G C D+DEC +
Sbjct: 919 ECTQVQHLCSQGRCENTEGSFLC-ICPAGFMASE-EGTN----------CIDVDECLRPD 966
Query: 379 NGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNG 438
G C NTVG+F+C C G+ Q C C +P+ P C+
Sbjct: 967 VCG---EGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCP---DEQCVNSPGS 1020
Query: 439 AVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNC 483
C G+ G C D+D C++ N C +C
Sbjct: 1021 YQCVPCTEGFRGWNGQC---LDVD-------ECLEPNV-CANGDC 1054
Score = 52.0 bits (123), Expect = 3e-06
Identities = 41/136 (30%), Positives = 58/136 (42%), Gaps = 25/136 (18%)
Query: 297 GYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFH-CEACPR--GYKG-TQ 352
G +CG PGL C + T GF+ C+ CP+ Y G Q
Sbjct: 565 GSQCGKALPGLSKQEDCCGTVG----------------TSWGFNKCQKCPKKPSYHGYNQ 608
Query: 353 VSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQS-QG 411
+ Y R + C DI+EC G C PN C NT+GS++C C++GF + +
Sbjct: 609 MMECLPGYKRVNNTFCQDINECQ--LQGVC-PNGECLNTMGSYRC-TCKIGFGPDPTFSS 664
Query: 412 CLPARTCHSPAHSPCH 427
C+P S PC+
Sbjct: 665 CVPDPPVISEEKGPCY 680
Score = 41.2 bits (95), Expect = 0.005
Identities = 30/101 (29%), Positives = 46/101 (45%), Gaps = 16/101 (15%)
Query: 319 ECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGN 378
EC + C G C+ G+ C+ C GY + +K C D++EC++ N
Sbjct: 1625 ECGILNGCENGR-CVRVQEGYTCD-CFDGY-----------HLDTAKMTCVDVNECDELN 1671
Query: 379 NG-GCDPNSICTNTVGSFKCGPCRLGFL-GNQSQGCLPART 417
N N+ C NT GS+KC C G++ ++ C P T
Sbjct: 1672 NRMSLCKNAKCINTDGSYKC-LCLPGYVPSDKPNYCTPLNT 1711
Score = 38.9 bits (89), Expect = 0.023
Identities = 27/91 (29%), Positives = 37/91 (40%), Gaps = 16/91 (17%)
Query: 308 QGNGTHCSDINECA-HADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQ 366
+ G + D +EC C+NT PG+ C C +G Y K
Sbjct: 1417 EAGGENYKDADECLLFGQEICKNGFCLNTRPGYEC-YCKQG-----------TYYDPVKL 1464
Query: 367 VCNDIDECNDGNNGGCDPNSICTNTVGSFKC 397
C D+DEC D ++ C C NT GS+ C
Sbjct: 1465 QCFDMDECQDPSS--CIDGQ-CVNTEGSYNC 1492
>gi|46249412 latent transforming growth factor beta binding protein 1
isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 87.4 bits (215), Expect = 6e-17
Identities = 77/252 (30%), Positives = 97/252 (38%), Gaps = 46/252 (18%)
Query: 283 CFRGVDCMEVYEYPGYRCGPCPPGLQ-GNGTHCSDINECAHADPCFPGSSCINTMPGFHC 341
C RG DC+ Y C CP G Q + C DINEC H C P C+NT FHC
Sbjct: 847 CQRG-DCINTAG--SYDC-TCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHC 902
Query: 342 EACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCR 401
C +G+ A + C DIDEC NN CD + C NT GSF+C C
Sbjct: 903 -VCQQGFS-----------ISADGRTCEDIDEC--VNNTVCDSHGFCDNTAGSFRC-LCY 947
Query: 402 LGFLGNQ-SQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQC---------NVGWAGN 451
GF Q QGC+ C S A C G+ C C G +
Sbjct: 948 QGFQAPQDGQGCVDVNECE--LLSGVCGEAFC-ENVEGSFLCVCADENQEYSPMTGQCRS 1004
Query: 452 GNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDG 511
D D+D ++ C N + +L PN +++ C G G
Sbjct: 1005 RTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQEC--------CCTSGAGWG 1056
Query: 512 IKNVEDNCRLFP 523
DNC +FP
Sbjct: 1057 -----DNCEIFP 1063
Score = 80.9 bits (198), Expect = 5e-15
Identities = 84/329 (25%), Positives = 121/329 (36%), Gaps = 65/329 (19%)
Query: 261 NTI--MECQVC--GFH-EQRSHCSP-NPCFRGVDCME--VYEYPG-YRCGPCPPGLQGNG 311
NT+ C+ C G+ QR C + C C + PG Y+C PC G +G
Sbjct: 649 NTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWN 708
Query: 312 THCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDI 371
C D++EC + C G C N + C +C +GY T + C DI
Sbjct: 709 GQCLDVDECLEPNVCANG-DCSNLEGSYMC-SCHKGYTRT-----------PDHKHCRDI 755
Query: 372 DECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTC---HSPAHSPCH 427
DEC GN N C NT GSF+C C G+ L C C H AH C
Sbjct: 756 DECQQGN---LCVNGQCKNTEGSFRC-TCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCR 811
Query: 428 IHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTP 487
G+ C C+ G+ +G + + + C+++ C++ +C+ T
Sbjct: 812 -------NTEGSFQCVCDQGYRASG--------LGDHCEDINECLEDKSVCQRGDCINTA 856
Query: 488 NSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKD------------QQNSDTDSF 535
S + G Q DD+ I E P + QQ +
Sbjct: 857 GSYDCTCPD---GFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISAD 913
Query: 536 GDACDNCPNVPNNDQKDTDGNGEGDACDN 564
G C++ NN D+ G CDN
Sbjct: 914 GRTCEDIDECVNNTVCDSHG-----FCDN 937
Score = 73.9 bits (180), Expect = 7e-13
Identities = 91/366 (24%), Positives = 127/366 (34%), Gaps = 65/366 (17%)
Query: 265 ECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHAD 324
+C+ + R C+ C + GYR G G HC DINEC
Sbjct: 792 QCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRAS-------GLGDHCEDINECLEDK 844
Query: 325 PCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDP 384
CINT + C CP G++ +D + C DI+EC + G C P
Sbjct: 845 SVCQRGDCINTAGSYDC-TCPDGFQ--------LD----DNKTCQDINECE--HPGLCGP 889
Query: 385 NSICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQ 443
C NT GSF C C+ GF + + C C + ++ C H C G+ C
Sbjct: 890 QGECLNTEGSFHC-VCQQGFSISADGRTCEDIDECVN--NTVCDSHGFC-DNTAGSFRCL 945
Query: 444 CNVGWAG--NGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGD 501
C G+ +G C +D + L + C+ E+ + +
Sbjct: 946 CYQGFQAPQDGQGC-----VDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTG 1000
Query: 502 QC------DDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDN--CPNVPNNDQKDT 553
QC D D D D K + C N CDN PNV + T
Sbjct: 1001 QCRSRTSTDLDVDVDQPKEEKKECYYNLND----------ASLCDNVLAPNVTKQECCCT 1050
Query: 554 DGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVG--DACDSCPEMSNPTQTD 611
G G GD C+ + CP + T+ G G A +S E D
Sbjct: 1051 SGAGWGDNCE-----------IFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKD 1099
Query: 612 ADSDLV 617
AD L+
Sbjct: 1100 ADECLL 1105
Score = 52.4 bits (124), Expect = 2e-06
Identities = 59/225 (26%), Positives = 76/225 (33%), Gaps = 49/225 (21%)
Query: 263 IMECQV----CGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDIN 318
I EC V CG HC P C Y GYR C DI+
Sbjct: 549 INECTVNPDICG----AGHCINLPVRYTCIC-----YEGYR-------FSEQQRKCVDID 592
Query: 319 ECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGN 378
EC C NT F C CP G+ ++ G C D+DEC +
Sbjct: 593 ECTQVQHLCSQGRCENTEGSFLC-ICPAGFMASE-EGTN----------CIDVDECLRPD 640
Query: 379 NGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNG 438
G C NTVG+F+C C G+ Q C C +P+ P C+
Sbjct: 641 VCG---EGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCP---DEQCVNSPGS 694
Query: 439 AVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNC 483
C G+ G C D+D C++ N C +C
Sbjct: 695 YQCVPCTEGFRGWNGQC---LDVD-------ECLEPNV-CANGDC 728
Score = 52.0 bits (123), Expect = 3e-06
Identities = 41/136 (30%), Positives = 58/136 (42%), Gaps = 25/136 (18%)
Query: 297 GYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFH-CEACPR--GYKG-TQ 352
G +CG PGL C + T GF+ C+ CP+ Y G Q
Sbjct: 239 GSQCGKALPGLSKQEDCCGTVG----------------TSWGFNKCQKCPKKPSYHGYNQ 282
Query: 353 VSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQS-QG 411
+ Y R + C DI+EC G C PN C NT+GS++C C++GF + +
Sbjct: 283 MMECLPGYKRVNNTFCQDINECQ--LQGVC-PNGECLNTMGSYRC-TCKIGFGPDPTFSS 338
Query: 412 CLPARTCHSPAHSPCH 427
C+P S PC+
Sbjct: 339 CVPDPPVISEEKGPCY 354
Score = 41.2 bits (95), Expect = 0.005
Identities = 30/101 (29%), Positives = 46/101 (45%), Gaps = 16/101 (15%)
Query: 319 ECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGN 378
EC + C G C+ G+ C+ C GY + +K C D++EC++ N
Sbjct: 1299 ECGILNGCENGR-CVRVQEGYTCD-CFDGY-----------HLDTAKMTCVDVNECDELN 1345
Query: 379 NG-GCDPNSICTNTVGSFKCGPCRLGFL-GNQSQGCLPART 417
N N+ C NT GS+KC C G++ ++ C P T
Sbjct: 1346 NRMSLCKNAKCINTDGSYKC-LCLPGYVPSDKPNYCTPLNT 1385
Score = 38.9 bits (89), Expect = 0.023
Identities = 27/91 (29%), Positives = 37/91 (40%), Gaps = 16/91 (17%)
Query: 308 QGNGTHCSDINECA-HADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQ 366
+ G + D +EC C+NT PG+ C C +G Y K
Sbjct: 1091 EAGGENYKDADECLLFGQEICKNGFCLNTRPGYEC-YCKQG-----------TYYDPVKL 1138
Query: 367 VCNDIDECNDGNNGGCDPNSICTNTVGSFKC 397
C D+DEC D ++ C C NT GS+ C
Sbjct: 1139 QCFDMDECQDPSS--CIDGQ-CVNTEGSYNC 1166
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 82.8 bits (203), Expect = 1e-15
Identities = 66/211 (31%), Positives = 85/211 (40%), Gaps = 39/211 (18%)
Query: 264 MECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHA 323
+ CQ ++ S C CF + + CG C PG Q G C D+NEC
Sbjct: 5188 LSCQDINECQESSPCHQR-CFNAIG--------SFHCG-CEPGYQLKGRKCMDVNEC-RQ 5236
Query: 324 DPCFPGSSCINTMPGFHC-EACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGC 382
+ C P C NT G+ C + CP G +A C DIDEC DG + C
Sbjct: 5237 NVCRPDQHCKNTRGGYKCIDLCPNG------------MTKAENGTCIDIDECKDGTH-QC 5283
Query: 383 DPNSICTNTVGSFKCGPCRLGFLGNQSQG----CLPARTCHSPAHSPCHIHAHCLFERNG 438
N IC NT GS++C C G+ +SQG C+ C PC AH G
Sbjct: 5284 RYNQICENTRGSYRC-VCPRGY---RSQGVGRPCMDINECEQ-VPKPC---AHQCSNTPG 5335
Query: 439 AVSCQCNVG--WAGNGNVCGTDTDIDGYPDQ 467
+ C C G G+G C + Y Q
Sbjct: 5336 SFKCICPPGQHLLGDGKSCAGLERLPNYGTQ 5366
Score = 75.5 bits (184), Expect = 2e-13
Identities = 70/226 (30%), Positives = 92/226 (40%), Gaps = 45/226 (19%)
Query: 297 GYRCGPCPPG--LQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVS 354
G R CP G L G C+D +ECA +PC SC N M ++C +CP+G
Sbjct: 5086 GDRSNQCPSGFTLDSVGPFCADEDECAAGNPC--SHSCHNAMGTYYC-SCPKGLT----- 5137
Query: 355 GVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKC-GPCRLGF-LGNQSQGC 412
A + C DIDEC G + C C NT+GS++C C GF + C
Sbjct: 5138 ------IAADGRTCQDIDECALGRH-TCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSC 5190
Query: 413 LPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCM 472
C SPCH F G+ C C G+ G C D++ C
Sbjct: 5191 QDINECQE--SSPCHQRC---FNAIGSFHCGCEPGYQLKGRKC---MDVN-------ECR 5235
Query: 473 DN----NKHCKQD----NCL-LTPNSGQEDADNDGVGDQCDDDADG 509
N ++HCK C+ L PN G A+N G D+ DG
Sbjct: 5236 QNVCRPDQHCKNTRGGYKCIDLCPN-GMTKAEN-GTCIDIDECKDG 5279
Score = 62.0 bits (149), Expect = 3e-09
Identities = 36/100 (36%), Positives = 48/100 (48%), Gaps = 17/100 (17%)
Query: 303 CPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYAR 362
CP G + + C DI+EC + D C C NT + C CP GY+ T
Sbjct: 5419 CPEGSEASHDTCVDIDECENTDAC--QHECKNTFGSYQC-ICPPGYQLTH---------- 5465
Query: 363 ASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKC--GPC 400
+ + C DIDEC + N C PN +C N GS++C PC
Sbjct: 5466 -NGKTCQDIDECLE-QNVHCGPNRMCFNMRGSYQCIDTPC 5503
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 82.0 bits (201), Expect = 2e-15
Identities = 97/378 (25%), Positives = 145/378 (38%), Gaps = 96/378 (25%)
Query: 298 YRCGPCPPG--LQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGY------- 348
Y C C G L +G C+DI+EC + G C N +PG + C G+
Sbjct: 1264 YECS-CSEGYALMPDGRSCADIDECENNPDICDGGQCTN-IPGEYRCLCYDGFMASMDMK 1321
Query: 349 -----------------------KGTQVSGVGIDYA-RASKQVCNDIDECNDGNNGGCDP 384
KG+ + + Y+ + C D+DEC G + CD
Sbjct: 1322 TCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAH-NCDM 1380
Query: 385 NSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQC 444
++ C N GSFKC CR G++GN + C+ C + H C I+A C+ G+ C C
Sbjct: 1381 HASCLNIPGSFKCS-CREGWIGNGIK-CIDLDECSNGTHQ-CSINAQCV-NTPGSYRCAC 1436
Query: 445 NVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCD 504
+ G+ G+G C +D+D C +N C+ CL P + + + +
Sbjct: 1437 SEGFTGDGFTC---SDVD-------ECAENINLCENGQCLNVPGAYRCECEM-------- 1478
Query: 505 DDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDAC--DNCPNVPN------NDQKDTDGN 556
G D ++ Q+ D SF + C C N+P +D + D
Sbjct: 1479 ------GFTPASD------SRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRT 1526
Query: 557 GEGDACDNDVDGDGI--PNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMS-NPTQTDAD 613
G G+ D D D I NGL C P + C+ P+ NPT
Sbjct: 1527 G-GNCTDIDECADPINCVNGL--CVNTPGRYE-----------CNCPPDFQLNPTGVGCV 1572
Query: 614 SDLVGDVCDTNEDSDGDG 631
+ VG+ C GDG
Sbjct: 1573 DNRVGN-CYLKFGPRGDG 1589
Score = 70.5 bits (171), Expect = 7e-12
Identities = 57/193 (29%), Positives = 76/193 (39%), Gaps = 30/193 (15%)
Query: 316 DINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECN 375
D+NEC + CINT F CE CP GY +DY C D DEC+
Sbjct: 2171 DVNECLESPGICSNGQCINTDGSFRCE-CPMGY--------NLDYTGVR---CVDTDECS 2218
Query: 376 DGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFE 435
GN G N CTN +GSF+C C GF C C A +P C+
Sbjct: 2219 IGNPCG---NGTCTNVIGSFECN-CNEGFEPGPMMNCEDINEC---AQNPLLCAFRCM-N 2270
Query: 436 RNGAVSCQCNVGWA--GNGNVCGTDTDIDGYPDQALPCMDNNKHCKQ----DNCLLTPNS 489
G+ C C +G+A + +C D+D + C CK C+ P
Sbjct: 2271 TFGSYECTCPIGYALREDQKMC---KDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGM 2327
Query: 490 GQEDADNDGVGDQ 502
+ D +G D+
Sbjct: 2328 ARR-PDGEGCVDE 2339
Score = 70.1 bits (170), Expect = 9e-12
Identities = 93/377 (24%), Positives = 147/377 (38%), Gaps = 78/377 (20%)
Query: 265 ECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPG-YRCGPCPPGLQGNGTHCSDINECAH- 322
EC++ G H H S C+ + PG ++C C G GNG C D++EC++
Sbjct: 1370 ECEI-GAHNCDMHAS---------CLNI---PGSFKCS-CREGWIGNGIKCIDLDECSNG 1415
Query: 323 ADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGC 382
C + C+NT + C AC G+ G + C+D+DEC + N C
Sbjct: 1416 THQCSINAQCVNTPGSYRC-ACSEGFTGDGFT-------------CSDVDECAE-NINLC 1460
Query: 383 DPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLF----ERNG 438
+ N C N G+++C C +GF +R+C C C+F G
Sbjct: 1461 E-NGQCLNVPGAYRC-ECEMGFTPASD-----SRSCQD--IDECSFQNICVFGTCNNLPG 1511
Query: 439 AVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADND- 497
C C+ G+ + G TDID D +C C+ TP + + D
Sbjct: 1512 MFHCICDDGYELD-RTGGNCTDIDECADPI--------NCVNGLCVNTPGRYECNCPPDF 1562
Query: 498 -----GVGDQCDDDADGD--------GIKNVEDNCRLFPNKDQQN---SDTDSFGDACDN 541
GVG C D+ G+ G ++ N + + + S ++G+ C+
Sbjct: 1563 QLNPTGVG--CVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCET 1620
Query: 542 CPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSC 601
CP V + + GEG N + I +D C ++P Q + G C
Sbjct: 1621 CPPVNSTEYYTLCPGGEGFR-PNPI--TIILEDIDECQELPGLCQGGNCINTFGSFQCEC 1677
Query: 602 PE---MSNPTQTDADSD 615
P+ +S T+ D D
Sbjct: 1678 PQGYYLSEDTRICEDID 1694
Score = 65.1 bits (157), Expect = 3e-10
Identities = 57/183 (31%), Positives = 73/183 (39%), Gaps = 29/183 (15%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTH--CSDINECAHADPCFPGSSCINT 335
C+ NPC G DC+ PG C G Q T C DI+EC C+NT
Sbjct: 539 CTSNPCTNG-DCVNT---PGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNT 594
Query: 336 MPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSF 395
F C C G++ T + C D DEC N N +C N GSF
Sbjct: 595 DGSFQC-ICNAGFELT-----------TDGKNCVDHDECTTTN---MCLNGMCINEDGSF 639
Query: 396 KCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWA--GNG 452
KC C+ GF L + C C +P ++ HC+ G+ C C G A +G
Sbjct: 640 KC-ICKPGFVLAPNGRYCTDVDECQTPG---ICMNGHCI-NSEGSFRCDCPPGLAVGMDG 694
Query: 453 NVC 455
VC
Sbjct: 695 RVC 697
Score = 65.1 bits (157), Expect = 3e-10
Identities = 61/209 (29%), Positives = 82/209 (39%), Gaps = 44/209 (21%)
Query: 300 CGPCP-PGLQGNGTHCS---------------DINECAHADPCFPGSSCINTMPGFHCEA 343
C PCP PG T C DI+EC CIN + F CE
Sbjct: 1776 CEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCE- 1834
Query: 344 CPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLG 403
CP G+ + VC DIDEC++G+N C N+ C N+ GS++C C G
Sbjct: 1835 CPTGFSYNDLL-----------LVCEDIDECSNGDN-LCQRNADCINSPGSYRC-ECAAG 1881
Query: 404 FLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGW-AGNGNVCGTDTDID 462
F + + C+ C + C H C+ + G+ C C+ G+ A D D
Sbjct: 1882 FKLSPNGACVDRNEC-LEIPNVCS-HGLCV-DLQGSYQCICHNGFKASQDQTMCMDVD-- 1936
Query: 463 GYPDQALPCMDNNKHCKQD----NCLLTP 487
+ PC N CK NCL P
Sbjct: 1937 --ECERHPC--GNGTCKNTVGSYNCLCYP 1961
Score = 64.7 bits (156), Expect = 4e-10
Identities = 52/179 (29%), Positives = 77/179 (43%), Gaps = 25/179 (13%)
Query: 281 NPCFRGVDCMEVYEYPGYRCGPCPPGLQ-GNGTHCSDINECAHADPCFPGSSCINTMPGF 339
NPC G C V + C C G + G +C DINECA +P C+NT +
Sbjct: 2221 NPCGNGT-CTNVIG--SFECN-CNEGFEPGPMMNCEDINECAQ-NPLLCAFRCMNTFGSY 2275
Query: 340 HCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGP 399
C CP GY R +++C D+DEC +G + +C N +G+F C
Sbjct: 2276 EC-TCPIGYA-----------LREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMC-I 2322
Query: 400 CRLGFLGN-QSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGW--AGNGNVC 455
C G +GC+ C + C + C+ G+ C+CN G+ + +G C
Sbjct: 2323 CPPGMARRPDGEGCVDENECRTKP-GICE-NGRCV-NIIGSYRCECNEGFQSSSSGTEC 2378
Score = 63.9 bits (154), Expect = 7e-10
Identities = 63/222 (28%), Positives = 84/222 (37%), Gaps = 33/222 (14%)
Query: 303 CPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYAR 362
CP G G T DI+EC CINTM F C C GY T +SG
Sbjct: 2437 CPHG-PGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRC-FCKVGYT-TDISGTS----- 2488
Query: 363 ASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPA 422
C D+DEC+ C N IC NT GS++C R L + C C +
Sbjct: 2489 -----CIDLDECSQSPKP-C--NYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQ 2540
Query: 423 HSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDN 482
H+ + + L G +C+C G+ + C ID + P + K
Sbjct: 2541 HNCQFLCVNTL----GGFTCKCPPGFTQHHTAC-----IDNNECGSQPSLCGAKGI---- 2587
Query: 483 CLLTPNS----GQEDADNDGVGDQCDDDADGDGIKNVEDNCR 520
C TP S Q D G C+D + DG + C+
Sbjct: 2588 CQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQ 2629
Score = 63.5 bits (153), Expect = 9e-10
Identities = 50/155 (32%), Positives = 72/155 (46%), Gaps = 24/155 (15%)
Query: 297 GYRCGPCPPGLQGNGTHCSDINEC-AHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSG 355
G+ C CPPG + T C D NEC + C C NT F CE C RG+ +
Sbjct: 2553 GFTC-KCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCE-CQRGF---SLDA 2607
Query: 356 VGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGN-QSQGCLP 414
G++ C D+DEC DGN+ C C N +G ++CG C G++ + Q C+
Sbjct: 2608 TGLN--------CEDVDEC-DGNH-RCQHG--CQNILGGYRCG-CPQGYIQHYQWNQCVD 2654
Query: 415 ARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWA 449
C +P + C A C + G+ C C G++
Sbjct: 2655 ENECSNP--NACG-SASC-YNTLGSYKCACPSGFS 2685
Score = 61.2 bits (147), Expect = 4e-09
Identities = 39/110 (35%), Positives = 53/110 (48%), Gaps = 20/110 (18%)
Query: 297 GYRCGPCPPGL--QGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVS 354
GYRCG CP G C D NEC++ + C +SC NT+ + C ACP G+ Q S
Sbjct: 2634 GYRCG-CPQGYIQHYQWNQCVDENECSNPNAC-GSASCYNTLGSYKC-ACPSGFSFDQFS 2690
Query: 355 GVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF 404
C+D++EC+ N N C+NT G + CG C G+
Sbjct: 2691 SA-----------CHDVNECSSSKN---PCNYGCSNTEGGYLCG-CPPGY 2725
Score = 60.8 bits (146), Expect = 6e-09
Identities = 55/208 (26%), Positives = 82/208 (39%), Gaps = 39/208 (18%)
Query: 283 CFRGVDCMEVYEYPGYRCGPCP-----------PGLQGNGTHCSDINECAHADPCFPGSS 331
C + + C + G+ C CP P ++ C D++EC G +
Sbjct: 234 CTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGA--CQDVDECQAIPGICQGGN 291
Query: 332 CINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNT 391
CINT+ F C CP G+K ++ + Q C DIDEC+ G C+ C+NT
Sbjct: 292 CINTVGSFECR-CPAGHKQSETT-----------QKCEDIDECSI-IPGICETGE-CSNT 337
Query: 392 VGSFKCGPCRLGFL-GNQSQGCLPART--CHSPAHSPCHIHAHCLFERNGAVS---CQCN 445
VGS+ C C G++ C+ RT C S ++ C E G ++ C C
Sbjct: 338 VGSYFC-VCPRGYVTSTDGSRCIDQRTGMCFSGL-----VNGRCAQELPGRMTKMQCCCE 391
Query: 446 VGWAGNGNVCGTDTDIDGYPDQALPCMD 473
G + G + CMD
Sbjct: 392 PGRCWGIGTIPEACPVRGSEEYRRLCMD 419
Score = 57.8 bits (138), Expect = 5e-08
Identities = 42/160 (26%), Positives = 67/160 (41%), Gaps = 28/160 (17%)
Query: 313 HCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDID 372
+C DI+EC G +C+NT F C+ CP G++ S++ C DI+
Sbjct: 1155 NCMDIDECERNPLLCRGGTCVNTEGSFQCD-CPLGHE-----------LSPSREDCVDIN 1202
Query: 373 ECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGN-QSQGCLPARTC---HSPAHSPCHI 428
EC+ +N N C N +G+++C C G+ QGC C + + C
Sbjct: 1203 ECSLSDN--LCRNGKCVNMIGTYQCS-CNPGYQATPDRQGCTDIDECMIMNGGCDTQC-- 1257
Query: 429 HAHCLFERNGAVSCQCNVGWA--GNGNVCGTDTDIDGYPD 466
G+ C C+ G+A +G C + + PD
Sbjct: 1258 -----TNSEGSYECSCSEGYALMPDGRSCADIDECENNPD 1292
Score = 57.4 bits (137), Expect = 6e-08
Identities = 90/358 (25%), Positives = 133/358 (37%), Gaps = 64/358 (17%)
Query: 313 HCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDID 372
+C+DI+EC + C+NT F CE C GY+ SG + C DID
Sbjct: 1112 NCTDIDECRISPDLCGSGICVNTPGSFECE-CFEGYE----SGF------MMMKNCMDID 1160
Query: 373 ECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHAH 431
EC N C NT GSF+C C LG L + C+ C S + + C +
Sbjct: 1161 ECE--RNPLLCRGGTCVNTEGSFQC-DCPLGHELSPSREDCVDINEC-SLSDNLCR-NGK 1215
Query: 432 CLFERNGAVSCQCNVGWAGNGNVCG-TDTD----IDGYPDQALPCMDNNKHCKQDNCLLT 486
C+ G C CN G+ + G TD D ++G D + + C
Sbjct: 1216 CV-NMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYAL 1274
Query: 487 PNSGQEDADNDGVGDQCD---DDADGDGIKNV--EDNCRLFP--------------NKDQ 527
G+ AD D+C+ D DG N+ E C + N+
Sbjct: 1275 MPDGRSCADI----DECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECD 1330
Query: 528 QNSDTDSFGDACDNCP-------NVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPK 580
NS+ FG+ C+N + + +K T G + D C+ + +C
Sbjct: 1331 LNSNICMFGE-CENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMH---ASCLN 1386
Query: 581 VPNPLQTDRDEDGVGDA--CDSCPEMSNPT-QTDADSDLVGDV----CDTNEDSDGDG 631
+P + E +G+ C E SN T Q ++ V C +E GDG
Sbjct: 1387 IPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDG 1444
Score = 57.4 bits (137), Expect = 6e-08
Identities = 40/119 (33%), Positives = 51/119 (42%), Gaps = 19/119 (15%)
Query: 281 NPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHC--SDINECAHADPCFPGSSCINTMPG 338
NPC C V Y P G + N DI+EC G +CINT
Sbjct: 1616 NPC---ETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGS 1672
Query: 339 FHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKC 397
F CE CP+GY Y ++C DIDEC + G C P + C NT+G++ C
Sbjct: 1673 FQCE-CPQGY-----------YLSEDTRICEDIDEC-FAHPGVCGPGT-CYNTLGNYTC 1717
Score = 55.5 bits (132), Expect = 2e-07
Identities = 73/294 (24%), Positives = 102/294 (34%), Gaps = 91/294 (30%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINEC-AHADPCFPGSSCINTM 336
C CF + + GY P +G +C D NEC A C PG +C N
Sbjct: 1985 CRNGRCFNEIGSFKCLCNEGYELTP-------DGKNCIDTNECVALPGSCSPG-TCQNLE 2036
Query: 337 PGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPN----SICTNTV 392
F C CP GY+ + C DI+EC++ DPN CTNT
Sbjct: 2037 GSFRC-ICPPGYE-------------VKSENCIDINECDE------DPNICLFGSCTNTP 2076
Query: 393 GSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVS----------- 441
G F+C C GF+ + + R C S C + FE NG S
Sbjct: 2077 GGFQC-LCPPGFVLSDN-----GRRCFDTRQSFCFTN----FE-NGKCSVPKAFNTTKAK 2125
Query: 442 CQCN----VGWAGNGNVCGTD-----TDIDGYPDQALP-----------CMDNNKHCKQD 481
C C+ GW +C D D+ Y +P C+++ C
Sbjct: 2126 CCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNG 2185
Query: 482 NCLLTPNSGQ----------------EDADNDGVGDQCDDDADGDGIKNVEDNC 519
C+ T S + D D +G+ C + + I + E NC
Sbjct: 2186 QCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNC 2239
Score = 54.3 bits (129), Expect = 5e-07
Identities = 54/175 (30%), Positives = 75/175 (42%), Gaps = 38/175 (21%)
Query: 297 GYRCGPCPP-------GLQGNGTHCS----DINECAHADPCFPGSSCINTMPGFHCEACP 345
G C PCP GL +G + DINECA C N + C C
Sbjct: 738 GEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCN-CN 796
Query: 346 RGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFL 405
GY+ AS + C DIDEC N CD N +C NT GS+ C C G++
Sbjct: 797 SGYEPD-----------ASGRNCIDIDECLV-NRLLCD-NGLCRNTPGSYSC-TCPPGYV 842
Query: 406 -GNQSQGCLPARTCHSPAHSPCHIHAHCLFERN--GAVSCQCNVG--WAGNGNVC 455
+++ C C S +PC ++ C RN G+ +C+C+ G + G +C
Sbjct: 843 FRTETETCEDINECES---NPC-VNGAC---RNNLGSFNCECSPGSKLSSTGLIC 890
Score = 53.5 bits (127), Expect = 9e-07
Identities = 89/359 (24%), Positives = 126/359 (35%), Gaps = 58/359 (16%)
Query: 298 YRCGPCPPGLQ--GNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSG 355
YRC C G + +G +C DI+EC C NT PG + CP GY
Sbjct: 791 YRCN-CNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNT-PGSYSCTCPPGY------- 841
Query: 356 VGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPA 415
R + C DI+EC + C N C N +GSF C C G S+
Sbjct: 842 ----VFRTETETCEDINECE---SNPC-VNGACRNNLGSFNC-ECSPG-----SKLSSTG 887
Query: 416 RTCHSPAHSPCHIH---AHCLFERNGAV---SCQCNVG--WAGNGNVCGTDTDIDG--YP 465
C C ++ + C NGA C +G W C DT
Sbjct: 888 LICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLAR 947
Query: 466 DQALPCMDNNKH------CKQDNCLLTPNSGQ----EDADNDGVGDQC-DDDADGDGIKN 514
+ + C D N+ C C+ + S E DG G C D + +K
Sbjct: 948 IKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKW 1007
Query: 515 VEDNC-RLFPNKDQQNSDTDSFGDA----CDNCPNVPNNDQKDTDGNGEGDACDNDV-DG 568
ED C P K + ++ + G A C+ CP + + G G A DV G
Sbjct: 1008 DEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTG 1067
Query: 569 DGIPNGLDNCPKVPNPLQTDRDEDGVGD---ACDS--CPEMSNPTQTDADSDLVG-DVC 621
++ C P + + +G C+S +M TD D + D+C
Sbjct: 1068 RPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLC 1126
Score = 50.8 bits (120), Expect = 6e-06
Identities = 69/249 (27%), Positives = 89/249 (35%), Gaps = 53/249 (21%)
Query: 285 RGVDCMEVYE---YPGY----RCG--------PCPPGL--QGNGTHCSDI---------- 317
+GV C +V E +PG RC CP GL G G C DI
Sbjct: 949 KGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWD 1008
Query: 318 -NECAHADPC-FPGSSC---INTMPGFHCEACPRG----YKGTQVSGVGIDY---ARASK 365
+EC H P F +C + G CE CP+ Y+ G G +
Sbjct: 1009 EDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGR 1068
Query: 366 QVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTCHSPAHS 424
DI+EC G C C NT+GSFKC C GF L + + C C S
Sbjct: 1069 PFYKDINECK-AFPGMCTYGK-CRNTIGSFKC-RCNSGFALDMEERNCTDIDECRI---S 1122
Query: 425 PCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCL 484
P + G+ C+C G+ + DID C N C+ C+
Sbjct: 1123 PDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDID-------ECERNPLLCRGGTCV 1175
Query: 485 LTPNSGQED 493
T S Q D
Sbjct: 1176 NTEGSFQCD 1184
Score = 30.4 bits (67), Expect = 8.2
Identities = 26/104 (25%), Positives = 41/104 (39%), Gaps = 16/104 (15%)
Query: 534 SFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDG 593
++G C+ CP P ++ N AC + +D C +P Q +
Sbjct: 246 AWGHPCEMCPAQPQPCRRGFIPNIRTGACQD----------VDECQAIPGICQGGNCINT 295
Query: 594 VGDACDSCP---EMSNPTQTDADSD---LVGDVCDTNEDSDGDG 631
VG CP + S TQ D D ++ +C+T E S+ G
Sbjct: 296 VGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVG 339
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 79.0 bits (193), Expect = 2e-14
Identities = 90/362 (24%), Positives = 136/362 (37%), Gaps = 59/362 (16%)
Query: 273 EQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSC 332
E C+ C G C++ + C CP G G H D ++PC G+ C
Sbjct: 337 ENIDDCAFASCTPGSTCID--RVASFSC-MCPEGKAGLLCHLDD---ACISNPCHKGALC 390
Query: 333 -INTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNT 391
N + G + CP+GYKG + D+DEC N+ C+ C NT
Sbjct: 391 DTNPLNGQYICTCPQGYKGADCT--------------EDVDECAMANSNPCEHAGKCVNT 436
Query: 392 VGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGN 451
G+F C C G+ G + + + CHS PC A CL ++ G +C C G+
Sbjct: 437 DGAFHC-ECLKGYAGPRCE--MDINECHS---DPCQNDATCL-DKIGGFTCLCMPGFK-- 487
Query: 452 GNVCGTDTDIDGYPDQALPCMDNNKHCKQDN---CLLTPNSGQEDADNDGVGDQCDDDAD 508
G +++ Q+ PC++N + + N CL P D D C
Sbjct: 488 ----GVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQID--IDDCSSTPC 541
Query: 509 GDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDG 568
+G K C PN + T G C+ N+ N D D C +
Sbjct: 542 LNGAK-----CIDHPNGYECQCATGFTGVLCEE--NIDNCDP---------DPCHHGQCQ 585
Query: 569 DGIPNGLDNC-PKVPNPLQTDRDEDGVGDAC---DSCPEMSNPTQTDADSDLVGDVCDTN 624
DGI + C P + +D+ ++ C C ++ N Q + G C+ N
Sbjct: 586 DGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEIN 645
Query: 625 ED 626
D
Sbjct: 646 FD 647
Score = 70.5 bits (171), Expect = 7e-12
Identities = 62/194 (31%), Positives = 79/194 (40%), Gaps = 39/194 (20%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCS-DINECAHADPCFPGSSCINTM 336
CSPNPC C E + Y C C PG QG C+ DI+EC + PC C NT
Sbjct: 837 CSPNPCENAAVCKESPNFESYTC-LCAPGWQGQ--RCTIDIDECI-SKPCMNHGLCHNTQ 892
Query: 337 PGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDEC--NDGNNGGCDPNSICTNTVGS 394
+ CE CP G+ G DID+C N NGG C + V +
Sbjct: 893 GSYMCE-CPPGFSGMDCE--------------EDIDDCLANPCQNGGS-----CMDGVNT 932
Query: 395 FKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAG---- 450
F C C GF G++ Q C S PC C N + +C+C G+ G
Sbjct: 933 FSC-LCLPGFTGDKCQ--TDMNECLS---EPCKNGGTCSDYVN-SYTCKCQAGFDGVHCE 985
Query: 451 -NGNVCGTDTDIDG 463
N N C + +G
Sbjct: 986 NNINECTESSCFNG 999
Score = 65.9 bits (159), Expect = 2e-10
Identities = 58/207 (28%), Positives = 87/207 (42%), Gaps = 45/207 (21%)
Query: 273 EQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCS-DINECAHADPCFPGSS 331
EQ C+ NPC G C + GYRC C PG Q G +C +++EC + PC G +
Sbjct: 1148 EQLDECASNPCQHGATCSDF--IGGYRC-ECVPGYQ--GVNCEYEVDECQN-QPCQNGGT 1201
Query: 332 CINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCND-IDECNDGNNGGCDPNSICTN 390
CI+ + F C +CP G +G +C + ID+C G + C C +
Sbjct: 1202 CIDLVNHFKC-SCPPGTRGL---------------LCEENIDDCARGPH--CLNGGQCMD 1243
Query: 391 TVGSFKCGPCRLGFLGNQSQG----CLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNV 446
+G + C C GF G + +G CL + C S C + C C
Sbjct: 1244 RIGGYSC-RCLPGFAGERCEGDINECL-SNPCSSEGSLDC-------IQLTNDYLCVCRS 1294
Query: 447 GWAGNGNVCGTDTDIDGYPDQALPCMD 473
+ G +T +D P +PC++
Sbjct: 1295 AFTGR----HCETFVDVCPQ--MPCLN 1315
Score = 62.8 bits (151), Expect = 1e-09
Identities = 88/359 (24%), Positives = 131/359 (36%), Gaps = 87/359 (24%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMP 337
C+ NPC G+ CM+ Y C C PG G + DI+ECA ++PC G++CIN +
Sbjct: 649 CASNPCIHGI-CMDGINR--YSC-VCSPGFTGQRCNI-DIDECA-SNPCRKGATCINGVN 702
Query: 338 GFHCEACPRG-------------YKGTQVSGVGIDYARASKQVCN--------DIDECND 376
GF C CP G + G K +C+ ++D+ N+
Sbjct: 703 GFRC-ICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDK-NE 760
Query: 377 GNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQ---------SQGCLPARTCHSP------ 421
+ C C N V ++C C+ GF G S CL TC
Sbjct: 761 CLSNPCQNGGTCDNLVNGYRC-TCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTC 819
Query: 422 ------------------AHSPCHIHAHCLFERN-GAVSCQCNVGWAGNGNVCGTDTDID 462
+ +PC A C N + +C C GW G D I
Sbjct: 820 HCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECI- 878
Query: 463 GYPDQALPCMDNNK-HCKQDN--CLLTPN-SG---QEDADNDGVGDQCDDDAD-GDGIKN 514
+ PCM++ H Q + C P SG +ED D D + + C + DG+
Sbjct: 879 -----SKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDID-DCLANPCQNGGSCMDGVNT 932
Query: 515 VEDNCRLFPNKDQQNSDTD---SFGDACDN---CPNVPNNDQKDTDGNGEGDACDNDVD 567
+C P TD + C N C + N+ +G C+N+++
Sbjct: 933 F--SCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNIN 989
Score = 61.6 bits (148), Expect = 3e-09
Identities = 52/208 (25%), Positives = 85/208 (40%), Gaps = 39/208 (18%)
Query: 264 MECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHA 323
M+C+ E C NPC G CM+ + C C PG G+ +D+NEC +
Sbjct: 906 MDCE-----EDIDDCLANPCQNGGSCMDGVN--TFSC-LCLPGFTGDKCQ-TDMNECL-S 955
Query: 324 DPCFPGSSCINTMPGFHCEACPRGYKGTQV--------------SGVGIDYARASKQVCN 369
+PC G +C + + + C+ C G+ G G +D + +C
Sbjct: 956 EPCKNGGTCSDYVNSYTCK-CQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCP 1014
Query: 370 -------DIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPA 422
+ E N+ ++ C C + +G+++C C LG+ G Q + C +
Sbjct: 1015 VGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCS-CPLGYTGKNCQTLV--NLC---S 1068
Query: 423 HSPCHIHAHCLFERNGAVSCQCNVGWAG 450
SPC C+ ++ C C GWAG
Sbjct: 1069 RSPCKNKGTCV-QKKAESQCLCPSGWAG 1095
Score = 59.3 bits (142), Expect = 2e-08
Identities = 48/171 (28%), Positives = 75/171 (43%), Gaps = 38/171 (22%)
Query: 303 CPPGLQGNGTHCSD-INECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYA 361
CP G G++C + ++ECA ++PC G++C + + G+ CE P GY+ GV +Y
Sbjct: 1137 CPLGY--TGSYCEEQLDECA-SNPCQHGATCSDFIGGYRCECVP-GYQ-----GVNCEY- 1186
Query: 362 RASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSP 421
++DEC N C C + V FKC C G ++G L
Sbjct: 1187 --------EVDEC---QNQPCQNGGTCIDLVNHFKCS-CPPG-----TRGLLCEENIDDC 1229
Query: 422 AHSPCHIHAHCLFERNGAVSCQCNVGWAGN----------GNVCGTDTDID 462
A P ++ +R G SC+C G+AG N C ++ +D
Sbjct: 1230 ARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLD 1280
Score = 51.6 bits (122), Expect = 3e-06
Identities = 50/201 (24%), Positives = 73/201 (36%), Gaps = 42/201 (20%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQG-NGTHC-SDINECAHADPCFPGSSCINT 335
C +PC G C V +C L G G C +D+NEC C G +C+N
Sbjct: 148 CLSHPCANGSTCTTVANQFSCKC------LTGFTGQKCETDVNECDIPGHCQHGGTCLNL 201
Query: 336 MPGFHCEACPRGYKGTQVSGVGIDYARA-------SKQVCNDIDECN------------- 375
+ C+ CP+G+ G + + A + +Q + ECN
Sbjct: 202 PGSYQCQ-CPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERN 260
Query: 376 --DGNNGGCDPNSICTNTVGSF--KCGPCRLG-FLGNQSQGCLPARTCHSPAHSPCHIHA 430
D N C +C + V ++ +C P G F CL + C
Sbjct: 261 IDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECL-------LQPNACQNGG 313
Query: 431 HCLFERNGAVSCQCNVGWAGN 451
C RNG C C GW+G+
Sbjct: 314 TCA-NRNGGYGCVCVNGWSGD 333
Score = 43.5 bits (101), Expect = 0.001
Identities = 90/384 (23%), Positives = 123/384 (32%), Gaps = 106/384 (27%)
Query: 324 DPCFPGSSCINTMPGFHCEACPRGYKG-------------TQVSGVGIDYARASKQVCND 370
+PC C+ G CP G+ G Q G + A K C
Sbjct: 33 EPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRC 92
Query: 371 I-----DECNDGNNGGCDPNSICTN-------TVGSFKCGPCRLGFLGNQ--------SQ 410
++C + C + C N + +++C C++GF G + S
Sbjct: 93 ASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYEC-TCQVGFTGKECQWTDACLSH 151
Query: 411 GCLPARTCHSPAH-------------------SPCHIHAHC-----LFERNGAVSCQCNV 446
C TC + A+ + C I HC G+ CQC
Sbjct: 152 PCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQ 211
Query: 447 GWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQD-------NCLLTPNSGQEDADNDGV 499
G+ G C D P PC+ N C+Q NCL G E + +
Sbjct: 212 GF--TGQYC----DSLYVPCAPSPCV-NGGTCRQTGDFTFECNCL----PGFEGSTCERN 260
Query: 500 GDQCDDDADGDGIKNVED----NCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDG 555
D C + +G V+ NCR P Q D D C PN N +
Sbjct: 261 IDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDV--DECLLQPNACQNGGTCANR 318
Query: 556 N-GEGDACDNDVDGDGIPNGLDNC---PKVPNPLQTDR--------DEDGVGDAC---DS 600
N G G C N GD +D+C P DR E G C D+
Sbjct: 319 NGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDA 378
Query: 601 CPEMSNPTQTDADSDLVGDVCDTN 624
C +SNP G +CDTN
Sbjct: 379 C--ISNPCHK-------GALCDTN 393
Score = 41.2 bits (95), Expect = 0.005
Identities = 76/318 (23%), Positives = 112/318 (35%), Gaps = 90/318 (28%)
Query: 276 SHCSPNPCFR--GVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCI 333
+ C NPC +DC+++ Y C C G HC + PC G +C
Sbjct: 1266 NECLSNPCSSEGSLDCIQLTN--DYLC-VCRSAFTGR--HCETFVDVCPQMPCLNGGTCA 1320
Query: 334 ---NTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTN 390
N GF C CP G+ G + + C + +C G C +
Sbjct: 1321 VASNMPDGFICR-CPPGFSGAR-----------CQSSCGQV-KCRKGEQ--------CVH 1359
Query: 391 TVGSFKCGPCRLGFLGNQSQGCLPARTCHSP-AHSPCHIHAHCLFERNGA-VSCQCNVGW 448
T +C C R C S A SPC C +R SCQC +
Sbjct: 1360 TASGPRC-------------FCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPF 1406
Query: 449 AGN-----------------GNVCGTDTDIDGYPDQALPCMDNNKHCKQD--NCLLTPNS 489
+G+ C D DG D+A N+ C+ D +C LT +
Sbjct: 1407 SGSRCELYTAPPSTPPATCLSQYC-ADKARDGVCDEAC----NSHACQWDGGDCSLTMEN 1461
Query: 490 GQEDADN-----DGVGDQCDDDADGDGIKNVEDNCRLFPNKD-QQNSDTDSFGDAC---- 539
+ + D + +QCD+ + VE C LF N + Q NS T + C
Sbjct: 1462 PWANCSSPLPCWDYINNQCDELCN-----TVE--C-LFDNFECQGNSKTCKYDKYCADHF 1513
Query: 540 --DNCPNVPNNDQKDTDG 555
++C N+++ DG
Sbjct: 1514 KDNHCDQGCNSEECGWDG 1531
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 78.2 bits (191), Expect = 3e-14
Identities = 59/189 (31%), Positives = 77/189 (40%), Gaps = 32/189 (16%)
Query: 270 GFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGN------GTHCS-DINECAH 322
GF ++ C ++G C E YPG G C Q N G C+ D+N C H
Sbjct: 235 GFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTH 294
Query: 323 ADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCN-DIDECNDGNNGG 381
PC G++C NT G + +C GY G C IDEC+
Sbjct: 295 HKPCKNGATCTNTGQGSYTCSCRPGYTGA---------------TCELGIDECDP---SP 336
Query: 382 CDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVS 441
C CT+ S+ C C GF G + L A TC A PC C +G S
Sbjct: 337 CKNGGSCTDLENSYSC-TCPPGFYGKICE--LSAMTC---ADGPCFNGGRCSDSPDGGYS 390
Query: 442 CQCNVGWAG 450
C+C VG++G
Sbjct: 391 CRCPVGYSG 399
Score = 63.2 bits (152), Expect = 1e-09
Identities = 48/174 (27%), Positives = 69/174 (39%), Gaps = 31/174 (17%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMP 337
C+ PCF G C + + GY C CP G +G +C + + PC G+ C++
Sbjct: 370 CADGPCFNGGRCSDSPD-GGYSCR-CPVGY--SGFNCEKKIDYCSSSPCSNGAKCVDLGD 425
Query: 338 GFHCEACPRGYKGTQVSGVGIDYARASKQVCND-IDECNDGNNGGCDPNSICTNTVGSFK 396
+ C C G+ G C+D +D+C + C C + V F
Sbjct: 426 AYLCR-CQAGFSGRH---------------CDDNVDDC---ASSPCANGGTCRDGVNDFS 466
Query: 397 CGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAG 450
C C G+ G P C H+PCH A C ER C+C G+ G
Sbjct: 467 C-TCPPGYTGRNCSA--PVSRCE---HAPCHNGATC-HERGHRYVCECARGYGG 513
Score = 50.8 bits (120), Expect = 6e-06
Identities = 36/123 (29%), Positives = 56/123 (45%), Gaps = 16/123 (13%)
Query: 277 HCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSD-INECAHADPCFPGSSCINT 335
+CS +PC G C+++ + Y C C G G HC D +++CA + PC G +C +
Sbjct: 408 YCSSSPCSNGAKCVDLGD--AYLCR-CQAGFSGR--HCDDNVDDCA-SSPCANGGTCRDG 461
Query: 336 MPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECND-GNNGGCDPNSICTNTVGS 394
+ F C CP GY G S +R C++ C++ G+ C+ C G
Sbjct: 462 VNDFSC-TCPPGYTGRNCSA---PVSRCEHAPCHNGATCHERGHRYVCE----CARGYGG 513
Query: 395 FKC 397
C
Sbjct: 514 PNC 516
Score = 33.1 bits (74), Expect = 1.3
Identities = 67/297 (22%), Positives = 91/297 (30%), Gaps = 72/297 (24%)
Query: 347 GYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLG 406
G +G +V G ++ +C + C D +G CD C CR+G+ G
Sbjct: 205 GERGEKVCNPGWKGPYCTEPIC--LPGC-DEQHGFCDKPGECK----------CRVGWQG 251
Query: 407 NQSQ------GCLPARTCHSP----------------------AHSPCHIHAHCLFERNG 438
GCL TC P H PC A C G
Sbjct: 252 RYCDECIRYPGCLHG-TCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQG 310
Query: 439 AVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDN---CLLTPN------- 488
+ +C C G+ G G D PC + +N C P
Sbjct: 311 SYTCSCRPGYTGATCELGID------ECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICE 364
Query: 489 -SGQEDADNDGV-GDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVP 546
S AD G +C D DG +CR N + D C + P
Sbjct: 365 LSAMTCADGPCFNGGRCSDSPDGG------YSCRCPVGYSGFNCEKKI--DYCSSSP--C 414
Query: 547 NNDQKDTD-GNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCP 602
+N K D G+ C G + +D+C P DGV D +CP
Sbjct: 415 SNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSP-CANGGTCRDGVNDFSCTCP 470
>gi|194328809 latent transforming growth factor beta binding protein
3 isoform 1 [Homo sapiens]
Length = 1303
Score = 77.8 bits (190), Expect = 5e-14
Identities = 92/307 (29%), Positives = 120/307 (39%), Gaps = 55/307 (17%)
Query: 296 PG-YRCGPCPPGL--QGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQ 352
PG ++C C PG QG G C D+NECA PC PG C N F C C +GY
Sbjct: 722 PGSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGW-CENLPGSFRC-TCAQGYAPAP 778
Query: 353 VSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQG 411
+ C D+DEC G+ CD N IC+NT GSF+C C G+ L
Sbjct: 779 -----------DGRSCLDVDECEAGDV--CD-NGICSNTPGSFQC-QCLSGYHLSRDRSH 823
Query: 412 CLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGW-AGNGNVCGTDTDIDGYPDQALP 470
C C PA I C+ NG+ C C G G C + P LP
Sbjct: 824 CEDIDECDFPA---ACIGGDCI-NTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLP 879
Query: 471 ---C--MDNNKHCKQDNCLLTPNSGQ---EDADNDGVGDQC----DDDADGDGIKNVEDN 518
C + + C D TP Q E+ + +C DD D +
Sbjct: 880 HGACKNLQGSYVCVCDEG-FTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSV------ 932
Query: 519 CRLFPNKDQQN---SDTDSFGDACD--NCPNVPNNDQKDTDGNGEGDACDNDVDGDGIP- 572
L N QQ S +GD C+ CP + + +G+G DN++ GIP
Sbjct: 933 --LATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPA 990
Query: 573 -NGLDNC 578
+D C
Sbjct: 991 HRDIDEC 997
Score = 68.6 bits (166), Expect = 3e-11
Identities = 65/209 (31%), Positives = 83/209 (39%), Gaps = 46/209 (22%)
Query: 265 ECQVCGFHEQRSHCSP----NPCFRGVDCMEVYEYPGYRCGP---------------CPP 305
EC V G + HC+P +P R C++V E CGP C
Sbjct: 589 EC-VPGPPDYSCHCNPGYRSHPQHRY--CVDVNECEAEPCGPGRGICMNTGGSYNCHCNR 645
Query: 306 GLQ----GNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYA 361
G + G C D+NECA C G CIN PG + C GY+
Sbjct: 646 GYRLHVGAGGRSCVDLNECAKPHLCGDGGFCIN-FPGHYKCNCYPGYR-----------L 693
Query: 362 RASK-QVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHS 420
+AS+ VC DIDEC D ++ C P+ C N GSFKC C+ G+ C C
Sbjct: 694 KASRPPVCEDIDECRDPSS--C-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNEC-- 748
Query: 421 PAHSPCHIHAHCLFERNGAVSCQCNVGWA 449
SPC G+ C C G+A
Sbjct: 749 AEGSPC--SPGWCENLPGSFRCTCAQGYA 775
Score = 54.3 bits (129), Expect = 5e-07
Identities = 46/146 (31%), Positives = 62/146 (42%), Gaps = 41/146 (28%)
Query: 297 GYRCGPCPPGLQGNGTHC----SDINECAHADPCFPGSS--------------------C 332
G +C PCPP +G G+HC S+ N P G C
Sbjct: 1171 GAQCRPCPP--RGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRC 1228
Query: 333 INTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGG-CDPNSICTNT 391
+ G CE CP G++ +D +RA C DIDEC + N G + C NT
Sbjct: 1229 VPRPGGAVCE-CPGGFQ--------LDASRAR---CVDIDECRELNQRGLLCKSERCVNT 1276
Query: 392 VGSFKCGPCRLGFLGNQSQG-CLPAR 416
GSF+C C+ GF ++ G C+P R
Sbjct: 1277 SGSFRC-VCKAGFARSRPHGACVPQR 1301
Score = 49.7 bits (117), Expect = 1e-05
Identities = 37/112 (33%), Positives = 47/112 (41%), Gaps = 23/112 (20%)
Query: 296 PGYRCGPCPPGL--QGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQV 353
PGY C C G GN C D++EC C G C NT G+ C P
Sbjct: 1015 PGYECY-CKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTPPA------ 1066
Query: 354 SGVGIDYARASKQVCN----DIDECNDGNNGGCDPNSICTNTVGSFKCGPCR 401
+Y+ A +Q + D+DEC D C P C N GS++C CR
Sbjct: 1067 -----EYSPAQRQCLSPEEMDVDECQD--PAACRPGR-CVNLPGSYRC-ECR 1109
Score = 48.9 bits (115), Expect = 2e-05
Identities = 41/158 (25%), Positives = 60/158 (37%), Gaps = 21/158 (13%)
Query: 316 DINECA--HADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDE 373
DI+EC ++ C G C+NT PG+ C C +G+ Y + C D+DE
Sbjct: 993 DIDECMLFGSEICKEGK-CVNTQPGYEC-YCKQGF-----------YYDGNLLECVDVDE 1039
Query: 374 CNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCL-PARTCHSPAHSPCHIHAHC 432
C D +N C N +C NT G ++C + CL P P
Sbjct: 1040 CLDESN--C-RNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGR 1096
Query: 433 LFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALP 470
G+ C+C W + G D + P + P
Sbjct: 1097 CVNLPGSYRCECRPPWVPGPS--GRDCQLPESPAERAP 1132
Score = 41.6 bits (96), Expect = 0.004
Identities = 21/47 (44%), Positives = 25/47 (53%), Gaps = 3/47 (6%)
Query: 303 CPPGLQG-NGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGY 348
CP G + N THC DINECA C G C+N + C CP G+
Sbjct: 341 CPQGYKRLNSTHCQDINECAMPGVCRHG-DCLNNPGSYRC-VCPPGH 385
Score = 38.9 bits (89), Expect = 0.023
Identities = 41/138 (29%), Positives = 54/138 (39%), Gaps = 27/138 (19%)
Query: 341 CEACPR-GYKGTQVSG-----VGID----YARASKQVCNDIDECNDGNNGGCDPNSICTN 390
C CP+ Y G Q G VG D Y R + C DI+EC G C + C N
Sbjct: 316 CHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVC-RHGDCLN 372
Query: 391 TVGSFKC--------GPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSC 442
GS++C GP R + ++ + ++ SP H H L R C
Sbjct: 373 NPGSYRCVCPPGHSLGPSRTQCIADKPE----EKSLCFRLVSPEHQCQHPLTTRLTRQLC 428
Query: 443 QCNVG--WAGNGNVCGTD 458
C+VG W C TD
Sbjct: 429 CCSVGKAWGARCQRCPTD 446
>gi|18497288 latent transforming growth factor beta binding protein
3 isoform 2 [Homo sapiens]
Length = 1256
Score = 77.8 bits (190), Expect = 5e-14
Identities = 92/307 (29%), Positives = 120/307 (39%), Gaps = 55/307 (17%)
Query: 296 PG-YRCGPCPPGL--QGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQ 352
PG ++C C PG QG G C D+NECA PC PG C N F C C +GY
Sbjct: 722 PGSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGW-CENLPGSFRC-TCAQGYAPAP 778
Query: 353 VSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQG 411
+ C D+DEC G+ CD N IC+NT GSF+C C G+ L
Sbjct: 779 -----------DGRSCLDVDECEAGDV--CD-NGICSNTPGSFQC-QCLSGYHLSRDRSH 823
Query: 412 CLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGW-AGNGNVCGTDTDIDGYPDQALP 470
C C PA I C+ NG+ C C G G C + P LP
Sbjct: 824 CEDIDECDFPA---ACIGGDCI-NTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLP 879
Query: 471 ---C--MDNNKHCKQDNCLLTPNSGQ---EDADNDGVGDQC----DDDADGDGIKNVEDN 518
C + + C D TP Q E+ + +C DD D +
Sbjct: 880 HGACKNLQGSYVCVCDEG-FTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSV------ 932
Query: 519 CRLFPNKDQQN---SDTDSFGDACD--NCPNVPNNDQKDTDGNGEGDACDNDVDGDGIP- 572
L N QQ S +GD C+ CP + + +G+G DN++ GIP
Sbjct: 933 --LATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPA 990
Query: 573 -NGLDNC 578
+D C
Sbjct: 991 HRDIDEC 997
Score = 68.6 bits (166), Expect = 3e-11
Identities = 65/209 (31%), Positives = 83/209 (39%), Gaps = 46/209 (22%)
Query: 265 ECQVCGFHEQRSHCSP----NPCFRGVDCMEVYEYPGYRCGP---------------CPP 305
EC V G + HC+P +P R C++V E CGP C
Sbjct: 589 EC-VPGPPDYSCHCNPGYRSHPQHRY--CVDVNECEAEPCGPGRGICMNTGGSYNCHCNR 645
Query: 306 GLQ----GNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYA 361
G + G C D+NECA C G CIN PG + C GY+
Sbjct: 646 GYRLHVGAGGRSCVDLNECAKPHLCGDGGFCIN-FPGHYKCNCYPGYR-----------L 693
Query: 362 RASK-QVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHS 420
+AS+ VC DIDEC D ++ C P+ C N GSFKC C+ G+ C C
Sbjct: 694 KASRPPVCEDIDECRDPSS--C-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNEC-- 748
Query: 421 PAHSPCHIHAHCLFERNGAVSCQCNVGWA 449
SPC G+ C C G+A
Sbjct: 749 AEGSPC--SPGWCENLPGSFRCTCAQGYA 775
Score = 54.3 bits (129), Expect = 5e-07
Identities = 46/146 (31%), Positives = 62/146 (42%), Gaps = 41/146 (28%)
Query: 297 GYRCGPCPPGLQGNGTHC----SDINECAHADPCFPGSS--------------------C 332
G +C PCPP +G G+HC S+ N P G C
Sbjct: 1124 GAQCRPCPP--RGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRC 1181
Query: 333 INTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGG-CDPNSICTNT 391
+ G CE CP G++ +D +RA C DIDEC + N G + C NT
Sbjct: 1182 VPRPGGAVCE-CPGGFQ--------LDASRAR---CVDIDECRELNQRGLLCKSERCVNT 1229
Query: 392 VGSFKCGPCRLGFLGNQSQG-CLPAR 416
GSF+C C+ GF ++ G C+P R
Sbjct: 1230 SGSFRC-VCKAGFARSRPHGACVPQR 1254
Score = 45.4 bits (106), Expect = 2e-04
Identities = 29/84 (34%), Positives = 42/84 (50%), Gaps = 18/84 (21%)
Query: 316 DINECA--HADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDE 373
DI+EC ++ C G C+NT PG+ C C +G+ Y + C D+DE
Sbjct: 993 DIDECMLFGSEICKEGK-CVNTQPGYEC-YCKQGF-----------YYDGNLLECVDVDE 1039
Query: 374 CNDGNNGGCDPNSICTNTVGSFKC 397
C D +N C N +C NT G ++C
Sbjct: 1040 CLDESN--C-RNGVCENTRGGYRC 1060
Score = 41.6 bits (96), Expect = 0.004
Identities = 21/47 (44%), Positives = 25/47 (53%), Gaps = 3/47 (6%)
Query: 303 CPPGLQG-NGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGY 348
CP G + N THC DINECA C G C+N + C CP G+
Sbjct: 341 CPQGYKRLNSTHCQDINECAMPGVCRHG-DCLNNPGSYRC-VCPPGH 385
Score = 38.9 bits (89), Expect = 0.023
Identities = 41/138 (29%), Positives = 54/138 (39%), Gaps = 27/138 (19%)
Query: 341 CEACPR-GYKGTQVSG-----VGID----YARASKQVCNDIDECNDGNNGGCDPNSICTN 390
C CP+ Y G Q G VG D Y R + C DI+EC G C + C N
Sbjct: 316 CHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINEC--AMPGVC-RHGDCLN 372
Query: 391 TVGSFKC--------GPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSC 442
GS++C GP R + ++ + ++ SP H H L R C
Sbjct: 373 NPGSYRCVCPPGHSLGPSRTQCIADKPE----EKSLCFRLVSPEHQCQHPLTTRLTRQLC 428
Query: 443 QCNVG--WAGNGNVCGTD 458
C+VG W C TD
Sbjct: 429 CCSVGKAWGARCQRCPTD 446
Score = 35.4 bits (80), Expect = 0.26
Identities = 20/52 (38%), Positives = 23/52 (44%), Gaps = 4/52 (7%)
Query: 296 PGYRCGPCPPGL--QGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACP 345
PGY C C G GN C D++EC C G C NT G+ C P
Sbjct: 1015 PGYECY-CKQGFYYDGNLLECVDVDECLDESNCRNG-VCENTRGGYRCACTP 1064
>gi|61743978 stabilin 1 precursor [Homo sapiens]
Length = 2570
Score = 77.4 bits (189), Expect = 6e-14
Identities = 63/246 (25%), Positives = 93/246 (37%), Gaps = 56/246 (22%)
Query: 266 CQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDIN------- 318
C+VC + PN C DC G C GLQG+G+ ++
Sbjct: 1367 CEVC----ELGRYGPN-CTGVCDCAH---------GLCQEGLQGDGSCVCNVGWQGLRCD 1412
Query: 319 ------ECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDID 372
+C C P ++C+ G AC GY G + C+++D
Sbjct: 1413 QKITSPQCPRK--CDPNANCVQDSAGASTCACAAGYSGNGI-------------FCSEVD 1457
Query: 373 ECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHC 432
C G+ GGC P++ CT + C+ G++G+ + C +C H CHIHA C
Sbjct: 1458 PCAHGH-GGCSPHANCTKVAPGQRTCTCQDGYMGD-GELCQEINSCLIH-HGGCHIHAEC 1514
Query: 433 LFERNGAVSCQCNVGWAGNG-NVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQ 491
+ VSC C G++G+G C + PC NN C + GQ
Sbjct: 1515 IPTGPQQVSCSCREGYSGDGIRTC----------ELLDPCSKNNGGCSPYATCKSTGDGQ 1564
Query: 492 EDADND 497
D
Sbjct: 1565 RTCTCD 1570
Score = 74.3 bits (181), Expect = 5e-13
Identities = 49/159 (30%), Positives = 69/159 (43%), Gaps = 19/159 (11%)
Query: 303 CPPGLQGNGTHCSDINECAHADP--CFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDY 360
C G +G+G C+ N C+H D C + C+ G H C +G+ G
Sbjct: 848 CLDGFEGDGFSCTPSNPCSHPDRGGCSENAECVPGSLGTHHCTCHKGWSG---------- 897
Query: 361 ARASKQVCNDIDECNDGNNGGCDPNSICTNT-VGSFKCGPCRLGFLGNQSQGCLPARTCH 419
+VC IDEC GGC +++C+ G +C C+LGF G+ Q C P C
Sbjct: 898 ---DGRVCVAIDECELDMRGGCHTDALCSYVGPGQSRC-TCKLGFAGDGYQ-CSPIDPCR 952
Query: 420 SPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTD 458
+ + CH A C G C C G+ G+G C D
Sbjct: 953 A-GNGGCHGLATCRAVGGGQRVCTCPPGFGGDGFSCYGD 990
Score = 61.6 bits (148), Expect = 3e-09
Identities = 53/194 (27%), Positives = 79/194 (40%), Gaps = 37/194 (19%)
Query: 284 FRGVDCMEV---YEYPGYRCGPCPPGLQGNGTH-------------CSDINECAHADPCF 327
F G DC + + P Y G C G+QGNG CS+ N+ H + C
Sbjct: 724 FFGPDCTQCPGGFSNPCYGKGNCSDGIQGNGACLCFPDYKGIACHICSNPNK--HGEQCQ 781
Query: 328 PGSSCINTMPGFHCEACPRG----YKGTQVSGVGIDYARASKQVCND-IDECND-GNNGG 381
C++ + C+ P +GT G S + CN+ + +C G
Sbjct: 782 EDCGCVHGL----CDNRPGSGGVCQQGTCAPGF-------SGRFCNESMGDCGPTGLAQH 830
Query: 382 CDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVS 441
C ++ C + G +C C GF G+ C P+ C P C +A C+ G
Sbjct: 831 CHLHARCVSQEGVARCR-CLDGFEGD-GFSCTPSNPCSHPDRGGCSENAECVPGSLGTHH 888
Query: 442 CQCNVGWAGNGNVC 455
C C+ GW+G+G VC
Sbjct: 889 CTCHKGWSGDGRVC 902
Score = 58.2 bits (139), Expect = 4e-08
Identities = 47/181 (25%), Positives = 69/181 (38%), Gaps = 29/181 (16%)
Query: 301 GPCPPGLQGNGTHCS--DINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGI 358
G C PG G + S D A C + C++ C C G++G S
Sbjct: 804 GTCAPGFSGRFCNESMGDCGPTGLAQHCHLHARCVSQEGVARCR-CLDGFEGDGFS---- 858
Query: 359 DYARASKQVCNDIDECNDGNNGGCDPNSICT-NTVGSFKCGPCRLGFLGNQSQGCLPART 417
C + C+ + GGC N+ C ++G+ C C G+ G+ + C+
Sbjct: 859 ---------CTPSNPCSHPDRGGCSENAECVPGSLGTHHC-TCHKGWSGD-GRVCVAIDE 907
Query: 418 CHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKH 477
C CH A C + G C C +G+AG+G C + ID PC N
Sbjct: 908 CELDMRGGCHTDALCSYVGPGQSRCTCKLGFAGDGYQC---SPID-------PCRAGNGG 957
Query: 478 C 478
C
Sbjct: 958 C 958
Score = 55.5 bits (132), Expect = 2e-07
Identities = 49/185 (26%), Positives = 71/185 (38%), Gaps = 34/185 (18%)
Query: 301 GPCPPGLQGNGTHCSDIN------------ECAHADPCFPGSSCINTMPGFHCEACPRGY 348
G C GL G+G+ D + PC P + C G CE C GY
Sbjct: 2027 GRCDEGLGGSGSCFCDEGWTGPRCEVQLELQPVCTPPCAPEAVC---RAGNSCE-CSLGY 2082
Query: 349 KGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQ 408
+G +VC D C DG+ GGC ++ C+ VG+ C + G+
Sbjct: 2083 EG-------------DGRVCTVADLCQDGH-GGCSEHANCSQ-VGTMVTCTCLPDYEGD- 2126
Query: 409 SQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTD--IDGYPD 466
C C C HA+CL C+C+ G+ G+G C +++ +D
Sbjct: 2127 GWSCRARNPCTDGHRGGCSEHANCLSTGLNTRRCECHAGYVGDGLQCLEESEPPVDRCLG 2186
Query: 467 QALPC 471
Q PC
Sbjct: 2187 QPPPC 2191
Score = 49.7 bits (117), Expect = 1e-05
Identities = 51/182 (28%), Positives = 61/182 (33%), Gaps = 29/182 (15%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMP 337
C C + C E P RC PG G+ C N C PC + C +
Sbjct: 199 CQELRCPQNTQCSA--EAPSCRC---LPGYTQQGSECRAPNPC-WPSPCSLLAQCSVSPK 252
Query: 338 GFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNS-ICTNTVGSFK 396
G CP Y G + VC D C D N GGC NS +C
Sbjct: 253 GQAQCHCPENYHGDGM-------------VCLPKDPCTD-NLGGCPSNSTLCVYQKPGQA 298
Query: 397 CGPCRLGFLG---NQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGN 453
CR G + N S GC + S C A C +G SC C G+G
Sbjct: 299 FCTCRPGLVSINSNASAGCFAFCSPFS-----CDRSATCQVTADGKTSCVCRESEVGDGR 353
Query: 454 VC 455
C
Sbjct: 354 AC 355
Score = 45.8 bits (107), Expect = 2e-04
Identities = 53/229 (23%), Positives = 69/229 (30%), Gaps = 82/229 (35%)
Query: 295 YPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVS 354
Y G RC CP G + PC +C++ M C ++G+
Sbjct: 104 YWGSRCHECPGGAE---------------TPCNGHGTCLDGMDRNGTCVCQENFRGSACQ 148
Query: 355 GVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGP-------CRLGFLGN 407
EC D N G D S+C+ G GP C G+ G
Sbjct: 149 ------------------ECQDPNRFGPDCQSVCSCVHGVCNHGPRGDGSCLCFAGYTGP 190
Query: 408 Q------------------------SQGCLPART-----CHSPAH---SPCHIHAHCLFE 435
S CLP T C +P SPC + A C
Sbjct: 191 HCDQELPVCQELRCPQNTQCSAEAPSCRCLPGYTQQGSECRAPNPCWPSPCSLLAQCSVS 250
Query: 436 RNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCL 484
G C C + G+G VC P PC DN C ++ L
Sbjct: 251 PKGQAQCHCPENYHGDGMVC--------LPKD--PCTDNLGGCPSNSTL 289
Score = 43.9 bits (102), Expect = 7e-04
Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 2/83 (2%)
Query: 369 NDIDECNDGNNGGCDPNSICTNTV-GSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCH 427
++ C G + C +C + + GS +C CR GF G + C P C
Sbjct: 1966 SECQACPGGPSSPCSDRGVCMDGMSGSGQC-LCRSGFAGTACELCAPGAFGPHCQACRCT 2024
Query: 428 IHAHCLFERNGAVSCQCNVGWAG 450
+H C G+ SC C+ GW G
Sbjct: 2025 VHGRCDEGLGGSGSCFCDEGWTG 2047
Score = 41.2 bits (95), Expect = 0.005
Identities = 40/144 (27%), Positives = 52/144 (36%), Gaps = 22/144 (15%)
Query: 302 PCPPGL---QGNGTHCS-----DINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQV 353
PC P GN CS D C AD C G G E GT V
Sbjct: 2063 PCAPEAVCRAGNSCECSLGYEGDGRVCTVADLCQDGH-------GGCSEHANCSQVGTMV 2115
Query: 354 SGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCL 413
+ + C + C DG+ GGC ++ C +T + + C G++G+ Q CL
Sbjct: 2116 TCTCLPDYEGDGWSCRARNPCTDGHRGGCSEHANCLSTGLNTRRCECHAGYVGDGLQ-CL 2174
Query: 414 -----PARTCHSPAHSPCHIHAHC 432
P C PCH A C
Sbjct: 2175 EESEPPVDRCLGQP-PPCHSDAMC 2197
Score = 38.9 bits (89), Expect = 0.023
Identities = 68/295 (23%), Positives = 94/295 (31%), Gaps = 68/295 (23%)
Query: 303 CPPGLQGNGTHCSDINEC--AHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDY 360
C PG G S+ C + PC C++ M G C G+ GT
Sbjct: 1959 CCPGHYG-----SECQACPGGPSSPCSDRGVCMDGMSGSGQCLCRSGFAGTACELCAPGA 2013
Query: 361 ARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHS 420
Q C C + C +G C G+ G + + L + +
Sbjct: 2014 FGPHCQACR------------CTVHGRCDEGLGGSGSCFCDEGWTGPRCEVQLELQPVCT 2061
Query: 421 PAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQ 480
P PC A C SC+C++G+ G+G VC T D+ C D + C +
Sbjct: 2062 P---PCAPEAVC----RAGNSCECSLGYEGDGRVC-TVADL---------CQDGHGGCSE 2104
Query: 481 D-NCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDAC 539
NC V C D +GDG +CR +N TD C
Sbjct: 2105 HANCSQVGTM---------VTCTCLPDYEGDGW-----SCR------ARNPCTDGHRGGC 2144
Query: 540 DNCPNVPNNDQKDTDGNGEGDACDNDVDGDGI------PNGLDNCPKVPNPLQTD 588
N T N C GDG+ +D C P P +D
Sbjct: 2145 SEHANC-----LSTGLNTRRCECHAGYVGDGLQCLEESEPPVDRCLGQPPPCHSD 2194
Score = 31.2 bits (69), Expect = 4.8
Identities = 22/71 (30%), Positives = 28/71 (39%), Gaps = 1/71 (1%)
Query: 288 DCMEVYEYPGYRCGPCPPGLQGNGTHCSDINEC-AHADPCFPGSSCINTMPGFHCEACPR 346
D + Y PG C G G+G CS I+ C A C ++C G CP
Sbjct: 919 DALCSYVGPGQSRCTCKLGFAGDGYQCSPIDPCRAGNGGCHGLATCRAVGGGQRVCTCPP 978
Query: 347 GYKGTQVSGVG 357
G+ G S G
Sbjct: 979 GFGGDGFSCYG 989
>gi|88758613 CD93 antigen precursor [Homo sapiens]
Length = 652
Score = 77.4 bits (189), Expect = 6e-14
Identities = 59/187 (31%), Positives = 75/187 (40%), Gaps = 28/187 (14%)
Query: 275 RSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTH--CSDINECAHADPCFPGSSC 332
R+ CS +PC G C+ Y C CP G Q + + C D++EC + PC C
Sbjct: 303 RNPCSSSPCRGGATCVLGPHGKNYTC-RCPQGYQLDSSQLDCVDVDECQDS-PC--AQEC 358
Query: 333 INTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTV 392
+NT GF CE VG + + C D+DEC G + CTNT
Sbjct: 359 VNTPGGFRCEC-----------WVGYEPGGPGEGACQDVDECALGRSPCAQG---CTNTD 404
Query: 393 GSFKCGPCRLGFL--GNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGW-- 448
GSF C C G++ G C C P C F G+ C C GW
Sbjct: 405 GSFHCS-CEEGYVLAGEDGTQCQDVDECVGPGGPLCD---SLCFNTQGSFHCGCLPGWVL 460
Query: 449 AGNGNVC 455
A NG C
Sbjct: 461 APNGVSC 467
>gi|61743980 stabilin 2 precursor [Homo sapiens]
Length = 2551
Score = 77.0 bits (188), Expect = 8e-14
Identities = 57/186 (30%), Positives = 79/186 (42%), Gaps = 20/186 (10%)
Query: 273 EQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADP--CFPGS 330
+Q S C P F + Y C C G +G+GT CS+++ C P C +
Sbjct: 825 KQTSACGPYVQFCHIHATCEYSNGTASC-ICKAGYEGDGTLCSEMDPCTGLTPGGCSRNA 883
Query: 331 SCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTN 390
CI T G H C +G+ G G D C++I+ C + GGC N+ C
Sbjct: 884 ECIKTGTGTHTCVCQQGWTGN-----GRD--------CSEINNCLLPSAGGCHDNASCLY 930
Query: 391 T-VGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWA 449
G +C C+ GF GN C P +C CH A C +G SC C G+
Sbjct: 931 VGPGQNEC-ECKKGFRGNGID-CEPITSCLEQT-GKCHPLASCQSTSSGVWSCVCQEGYE 987
Query: 450 GNGNVC 455
G+G +C
Sbjct: 988 GDGFLC 993
Score = 64.7 bits (156), Expect = 4e-10
Identities = 45/154 (29%), Positives = 64/154 (41%), Gaps = 17/154 (11%)
Query: 303 CPPGLQGNGTHCSDINECAHAD-PCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYA 361
C G QGNGT C+ IN C ++ C + C T PG C GY G +
Sbjct: 1458 CAAGFQGNGTICTAINACEISNGGCSAKADCKRTTPGRRVCTCKAGYTGDGI-------- 1509
Query: 362 RASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSP 421
VC +I+ C + N+GGCD N+ CT T + C + G+ + C C +
Sbjct: 1510 -----VCLEINPCLE-NHGGCDKNAECTQTGPNQAACNCLPAYTGD-GKVCTLINVCLT- 1561
Query: 422 AHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVC 455
+ C A C +C C + G+G C
Sbjct: 1562 KNGGCSEFAICNHTGQVERTCTCKPNYIGDGFTC 1595
Score = 62.0 bits (149), Expect = 3e-09
Identities = 46/156 (29%), Positives = 61/156 (39%), Gaps = 21/156 (13%)
Query: 303 CPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYAR 362
C P +G+G +C IN C C P + C P H C GY+G
Sbjct: 224 CLPNYRGDGKYCDPINPCLRKI-CHPHAHCTYLGPNRHSCTCQEGYRG------------ 270
Query: 363 ASKQVCNDIDECNDGNNGGCDPNS-ICT-NTVGSFKCGPCRLGFLGN-QSQGCLPARTCH 419
QVC +D C N G C S +C + G C C+ + GC C
Sbjct: 271 -DGQVCLPVDPCQI-NFGNCPTKSTVCKYDGPGQSHC-ECKEHYQNFVPGVGCSMTDICK 327
Query: 420 SPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVC 455
S +PCH +A+C G C C G+ G+G C
Sbjct: 328 SD--NPCHRNANCTTVAPGRTECICQKGYVGDGLTC 361
Score = 58.5 bits (140), Expect = 3e-08
Identities = 42/151 (27%), Positives = 63/151 (41%), Gaps = 22/151 (14%)
Query: 311 GTHCSDINEC--AHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVC 368
G + D N+C ++PC C +++ G C G++G+Q Q C
Sbjct: 731 GFYGPDCNQCPGGFSNPCSGNGQCADSLGGNGTCICEEGFQGSQC------------QFC 778
Query: 369 NDIDECNDGNNGGC-DPNSICTNTV---GSFKCGPCRLGFLGNQSQGCLPARTCHSPAHS 424
+D ++ N C + C N + G+ G CR G G C + P
Sbjct: 779 SDPNKYGPRCNKKCLCVHGTCNNRIDSDGACLTGTCRDGSAGRL---CDKQTSACGPYVQ 835
Query: 425 PCHIHAHCLFERNGAVSCQCNVGWAGNGNVC 455
CHIHA C + NG SC C G+ G+G +C
Sbjct: 836 FCHIHATCEYS-NGTASCICKAGYEGDGTLC 865
Score = 56.6 bits (135), Expect = 1e-07
Identities = 48/188 (25%), Positives = 65/188 (34%), Gaps = 51/188 (27%)
Query: 278 CSPNPCFRGVDCMEVYE-YPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTM 336
C P C R V E + G +C PCP Q + CF C++ +
Sbjct: 1323 CQPK-CVRTVITRECCAGFFGPQCQPCPGNAQ---------------NVCFGNGICLDGV 1366
Query: 337 PGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNG-GCDPNSICTNTVGSF 395
G C G+ GT + C +G G CD C +
Sbjct: 1367 NGTGVCECGEGFSGTAC------------------ETCTEGKYGIHCDQACSCVH----- 1403
Query: 396 KCGPCRLGFLGNQSQGC--------LPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVG 447
G C G LG+ S C T + CH A+CL +G SC+C G
Sbjct: 1404 --GRCNQGPLGDGSCDCDVGWRGVHCDNATTEDNCNGTCHTSANCLTNSDGTASCKCAAG 1461
Query: 448 WAGNGNVC 455
+ GNG +C
Sbjct: 1462 FQGNGTIC 1469
Score = 53.5 bits (127), Expect = 9e-07
Identities = 69/250 (27%), Positives = 89/250 (35%), Gaps = 33/250 (13%)
Query: 286 GVDCMEVYEYPGYRC---GPCPPGLQGNGT-HCSD------INECAHADPCFPGSSCINT 335
G DC+E G C G C G++GNGT C + C AD G SC +
Sbjct: 106 GPDCIECPGGAGSPCNGRGSCAEGMEGNGTCSCQEGFGGTACETC--ADDNLFGPSCSSV 163
Query: 336 MPGFHCEACPRGYKGTQVSGVGIDYARASKQVCN-DIDECND---GNNGGCDPNSICTNT 391
H C G G G Y+ + C+ I EC N C P++ N
Sbjct: 164 CNCVH-GVCNSGLDG---DGTCECYSAYTGPKCDKPIPECAALLCPENSRCSPSTEDENK 219
Query: 392 VGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGN 451
+ KC P G + C P C CH HAHC + SC C G+ G+
Sbjct: 220 L-ECKCLPNYRG----DGKYCDPINPC---LRKICHPHAHCTYLGPNRHSCTCQEGYRGD 271
Query: 452 GNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADN--DGVGDQCDDDADG 509
G VC +D C + CK D + +E N GVG D
Sbjct: 272 GQVC---LPVDPCQINFGNCPTKSTVCKYDGPGQSHCECKEHYQNFVPGVGCSMTDICKS 328
Query: 510 DGIKNVEDNC 519
D + NC
Sbjct: 329 DNPCHRNANC 338
Score = 50.8 bits (120), Expect = 6e-06
Identities = 52/219 (23%), Positives = 76/219 (34%), Gaps = 34/219 (15%)
Query: 266 CQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADP 325
C++C C P C C + G +C C G G + P
Sbjct: 1997 CEMCWPGRFGPDCLPCGCSDHGQCDDGITGSG-QC-LCETGWTGPSCDTQAVLPAVCTPP 2054
Query: 326 CFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPN 385
C ++C CE C Y+G ++ C +D C +NGGC
Sbjct: 2055 CSAHATCKENNT---CE-CNLDYEGDGIT-------------CTVVDFCKQ-DNGGCAKV 2096
Query: 386 SICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCN 445
+ C+ C C+ G+ G+ C C + CH HA C G C+C
Sbjct: 2097 ARCSQKGTKVSCS-CQKGYKGD-GHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECK 2154
Query: 446 VGWAGNGNVCGTDTDIDGYPDQALP---CMDNNKHCKQD 481
+ G+G C P+Q LP C+ +N C D
Sbjct: 2155 SHYVGDGLNC--------EPEQ-LPIDRCLQDNGQCHAD 2184
Score = 50.8 bits (120), Expect = 6e-06
Identities = 46/161 (28%), Positives = 64/161 (39%), Gaps = 28/161 (17%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADP-CFPGSSCINTM 336
C+P PC C E C C +G+G C+ ++ C + C + C
Sbjct: 2051 CTP-PCSAHATCKE-----NNTC-ECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKG 2103
Query: 337 PGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNT-VGSF 395
C +C +GYKG S C +ID C DG NGGC ++ C T G
Sbjct: 2104 TKVSC-SCQKGYKGDGHS-------------CTEIDPCADGLNGGCHEHATCKMTGPGKH 2149
Query: 396 KCGPCRLGFLG---NQSQGCLPARTCHSPAHSPCHIHAHCL 433
KC C+ ++G N LP C + CH A C+
Sbjct: 2150 KC-ECKSHYVGDGLNCEPEQLPIDRCLQD-NGQCHADAKCV 2188
Score = 49.7 bits (117), Expect = 1e-05
Identities = 48/204 (23%), Positives = 68/204 (33%), Gaps = 33/204 (16%)
Query: 370 DIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIH 429
D C G + C+ +C + + C GF G + C P R C H
Sbjct: 1958 DCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCLPCGCSDH 2017
Query: 430 AHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNS 489
C G+ C C GW G C T + P P + CK++N
Sbjct: 2018 GQCDDGITGSGQCLCETGWTGPS--CDTQAVL---PAVCTPPCSAHATCKENNTC----- 2067
Query: 490 GQEDADNDGVGDQCDDDADGDGIK-NVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNN 548
+C+ D +GDGI V D C+ Q N V +
Sbjct: 2068 ------------ECNLDYEGDGITCTVVDFCK------QDNGGCAKVARCSQKGTKVSCS 2109
Query: 549 DQKDTDGNG----EGDACDNDVDG 568
QK G+G E D C + ++G
Sbjct: 2110 CQKGYKGDGHSCTEIDPCADGLNG 2133
Score = 43.9 bits (102), Expect = 7e-04
Identities = 34/126 (26%), Positives = 47/126 (37%), Gaps = 17/126 (13%)
Query: 283 CFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINEC-AHADPCFPGSSCINTMPGFHC 341
C DC PG R C G G+G C +IN C + C + C T P
Sbjct: 1482 CSAKADCKRTT--PGRRVCTCKAGYTGDGIVCLEINPCLENHGGCDKNAECTQTGPNQAA 1539
Query: 342 EACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCR 401
C Y G +VC I+ C NGGC +IC +T + C+
Sbjct: 1540 CNCLPAYTG-------------DGKVCTLINVCLT-KNGGCSEFAICNHTGQVERTCTCK 1585
Query: 402 LGFLGN 407
++G+
Sbjct: 1586 PNYIGD 1591
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/139 (29%), Positives = 53/139 (38%), Gaps = 24/139 (17%)
Query: 381 GCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAV 440
GC P C TV + +C C GF G Q Q C A + C + CL NG
Sbjct: 1322 GCQPK--CVRTVITREC--CA-GFFGPQCQ------PCPGNAQNVCFGNGICLDGVNGTG 1370
Query: 441 SCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVG 500
C+C G++G T+ + DQA C+ + C Q G D D G
Sbjct: 1371 VCECGEGFSGTACETCTEGKYGIHCDQACSCV--HGRCNQGPL----GDGSCDCDVGWRG 1424
Query: 501 DQCDDDADGDGIKNVEDNC 519
CD+ EDNC
Sbjct: 1425 VHCDN-------ATTEDNC 1436
Score = 34.3 bits (77), Expect = 0.57
Identities = 30/108 (27%), Positives = 42/108 (38%), Gaps = 12/108 (11%)
Query: 400 CRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDT 459
C G+ G Q C +PC+ CL + + C+CN G+ NG C
Sbjct: 1950 CCKGYFGRDCQAC------PGGPDAPCNNRGVCLDQYSATGECKCNTGF--NGTACEMCW 2001
Query: 460 DIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDA 507
PD LPC + H + D+ + SGQ + G CD A
Sbjct: 2002 PGRFGPD-CLPC-GCSDHGQCDDGI--TGSGQCLCETGWTGPSCDTQA 2045
Score = 31.6 bits (70), Expect = 3.7
Identities = 19/67 (28%), Positives = 27/67 (40%), Gaps = 2/67 (2%)
Query: 293 YEYPGYRCGPCPPGLQG--NGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKG 350
Y+ PG C Q G CS + C +PC ++C PG C +GY G
Sbjct: 297 YDGPGQSHCECKEHYQNFVPGVGCSMTDICKSDNPCHRNANCTTVAPGRTECICQKGYVG 356
Query: 351 TQVSGVG 357
++ G
Sbjct: 357 DGLTCYG 363
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 76.6 bits (187), Expect = 1e-13
Identities = 70/249 (28%), Positives = 93/249 (37%), Gaps = 52/249 (20%)
Query: 278 CSPNPCFRGVDCMEVYEYPG-YRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTM 336
C+ PC G+ Y+ PG +RC C PG G S + + PC G +C +
Sbjct: 699 CAHEPCSHGI----CYDAPGGFRC-VCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDG 753
Query: 337 PGFHCEACPRGYKGTQVS------------GVGIDYARASKQVCN------------DID 372
GFHC CP G +G Q G + A VC+ D+D
Sbjct: 754 MGFHC-TCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVD 812
Query: 373 ECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHC 432
EC C P+ ICTN GSF C C G+ G + + +PC C
Sbjct: 813 EC--AGPAPCGPHGICTNLAGSFSC-TCHGGYTGPSCD-----QDINDCDPNPCLNGGSC 864
Query: 433 LFERNGAVSCQCNVGWAGN----------GNVCGTDTDIDGYPDQALPCMD--NNKHCKQ 480
+ G+ SC C G+AG N CG T D C HC+Q
Sbjct: 865 Q-DGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQ 923
Query: 481 DNCLLTPNS 489
D +P+S
Sbjct: 924 DLPDCSPSS 932
Score = 69.3 bits (168), Expect = 2e-11
Identities = 94/375 (25%), Positives = 132/375 (35%), Gaps = 85/375 (22%)
Query: 267 QVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCS-DINECAHADP 325
Q C PN C G C G+ C C G G CS +I++CA A
Sbjct: 269 QFCTEDVDECQLQPNACHNGGTCFNTLG--GHSC-VCVNGWTGES--CSQNIDDCATA-V 322
Query: 326 CFPGSSCINTMPGFHCEACPRGYKG--TQVSGVGIDYARASKQVCN-------------- 369
CF G++C + + F+C ACP G G + + +C+
Sbjct: 323 CFHGATCHDRVASFYC-ACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPP 381
Query: 370 ---------DIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHS 420
D+DEC+ G N C+ C NT GSF C C G+ G + + C S
Sbjct: 382 GFTGGACDQDVDECSIGAN-PCEHLGRCVNTQGSFLC-QCGRGYTGPRCE--TDVNECLS 437
Query: 421 PAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQ 480
PC A CL +R G +C C G+ G C D D Q+ PC+ N CK
Sbjct: 438 ---GPCRNQATCL-DRIGQFTCICMAGF--TGTYCEVDID----ECQSSPCV-NGGVCK- 485
Query: 481 DNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACD 540
D N G C G + D C P ++
Sbjct: 486 ------------DRVN-GFSCTCPSGFSGSTCQLDVDECASTPCRNGA------------ 520
Query: 541 NCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDS 600
C + P+ + EG CD +V D+C P+P R DG+ +
Sbjct: 521 KCVDQPDGYECRCAEGFEGTLCDRNV---------DDCS--PDPCHHGRCVDGIASFSCA 569
Query: 601 CPEMSNPTQTDADSD 615
C T+ ++ D
Sbjct: 570 CAPGYTGTRCESQVD 584
Score = 64.7 bits (156), Expect = 4e-10
Identities = 77/277 (27%), Positives = 97/277 (35%), Gaps = 64/277 (23%)
Query: 273 EQRSHCSPNPCFRGVDCMEVYEYPGYR--CGPCPPGLQGNGTHCSDINECAHADPCFPGS 330
E S C+PNPC G C PG C CP G QG D++ECA PC P
Sbjct: 770 ELLSPCTPNPCEHGGRCESA---PGQLPVCS-CPQGWQGPRCQ-QDVDECAGPAPCGPHG 824
Query: 331 SCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDEC--NDGNNGGCDPNSIC 388
C N F C C GY G DI++C N NGG C
Sbjct: 825 ICTNLAGSFSC-TCHGGYTGPSCD--------------QDINDCDPNPCLNGGS-----C 864
Query: 389 TNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGW 448
+ VGSF C C GF G + AR +PC + + +C C G+
Sbjct: 865 QDGVGSFSCS-CLPGFAGPRC-----ARDVDECLSNPC--GPGTCTDHVASFTCTCPPGY 916
Query: 449 AG----------------NGNVCGTDTDIDGYPDQALPCMD--NNKHCKQ--DNCLLTP- 487
G NG C +DG + C HC+ D CL P
Sbjct: 917 GGFHCEQDLPDCSPSSCFNGGTC-----VDGVNSFSCLCRPGYTGAHCQHEADPCLSRPC 971
Query: 488 -NSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFP 523
+ G A + G C + G + + D C P
Sbjct: 972 LHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQP 1008
Score = 62.8 bits (151), Expect = 1e-09
Identities = 59/206 (28%), Positives = 76/206 (36%), Gaps = 35/206 (16%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMP 337
C +PC G C V + C CPPG QG SD++EC +PC G +C+NT
Sbjct: 123 CLSSPCAHGARC-SVGPDGRFLCS-CPPGYQGRSCR-SDVDECRVGEPCRHGGTCLNTPG 179
Query: 338 GFHCEACPRGYKGTQVSGVGIDYA----------RASKQVCNDIDECNDGNNG-GCDPN- 385
F C+ CP GY G + A R S + D C G G C+ N
Sbjct: 180 SFRCQ-CPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDC-ACLPGFEGQNCEVNV 237
Query: 386 -----------SICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLF 434
C + V ++ C C + G Q C + CH C F
Sbjct: 238 DDCPGHRCLNGGTCVDGVNTYNC-QCPPEWTG---QFCTEDVDECQLQPNACHNGGTC-F 292
Query: 435 ERNGAVSCQCNVGWAGNGNVCGTDTD 460
G SC C GW G C + D
Sbjct: 293 NTLGGHSCVCVNGWTGES--CSQNID 316
Score = 60.5 bits (145), Expect = 7e-09
Identities = 92/367 (25%), Positives = 129/367 (35%), Gaps = 70/367 (19%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHC-SDINECAHADPCFPGSSCINTM 336
CSP+PC G C++ + C C PG GT C S ++EC + PC G C++ +
Sbjct: 549 CSPDPCHHG-RCVD--GIASFSCA-CAPGY--TGTRCESQVDEC-RSQPCRHGGKCLDLV 601
Query: 337 PGFHCEACPRGYKGTQVSGVGIDYARASK---QVCND------------------IDECN 375
+ C CP G G V ID ++ VC D E N
Sbjct: 602 DKYLCR-CPSGTTGVNCE-VNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEIN 659
Query: 376 DGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFE 435
+ + C C + F+C L G+ CLP H AH PC H C ++
Sbjct: 660 ECASSPCGEGGSCVDGENGFRC----LCPPGSLPPLCLP--PSHPCAHEPCS-HGIC-YD 711
Query: 436 RNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQD----NCLLTP--NS 489
G C C GW+G C D Q PC C D +C P
Sbjct: 712 APGGFRCVCEPGWSGPR--CSQSLARDACESQ--PCRAGGT-CSSDGMGFHCTCPPGVQG 766
Query: 490 GQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPN----KDQQNSDTDSFGDACDN---C 542
Q + + + C+ + C + QQ+ D + C C
Sbjct: 767 RQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGIC 826
Query: 543 PNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNP-LQTDRDEDGVGD-ACDS 600
N+ + G G +CD D+ N D PNP L +DGVG +C
Sbjct: 827 TNLAGSFSCTCHGGYTGPSCDQDI------NDCD-----PNPCLNGGSCQDGVGSFSCSC 875
Query: 601 CPEMSNP 607
P + P
Sbjct: 876 LPGFAGP 882
Score = 55.8 bits (133), Expect = 2e-07
Identities = 53/198 (26%), Positives = 77/198 (38%), Gaps = 42/198 (21%)
Query: 283 CFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCE 342
C G C++ E + C CP G G+HC + A PC G +C M G+ CE
Sbjct: 1055 CQAGGQCVD--EDSSHYC-VCPEGR--TGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCE 1109
Query: 343 ACPRGYKG--------------TQVSGVGIDYARASKQVCN------------DIDECND 376
P GY G Q G ID ++ +C+ + D+C
Sbjct: 1110 CLP-GYNGDNCEDDVDECASQPCQHGGSCIDL--VARYLCSCPPGTLGVLCEINEDDCGP 1166
Query: 377 G----NNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHC 432
G + C N C + VG F+C C G+ G + + + C S A H C
Sbjct: 1167 GPPLDSGPRCLHNGTCVDLVGGFRC-TCPPGYTGLRCEADI--NECRSGACHAAHTR-DC 1222
Query: 433 LFERNGAVSCQCNVGWAG 450
L + G C C+ G++G
Sbjct: 1223 LQDPGGGFRCLCHAGFSG 1240
Score = 49.7 bits (117), Expect = 1e-05
Identities = 57/232 (24%), Positives = 83/232 (35%), Gaps = 36/232 (15%)
Query: 270 GFHEQRS--HCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCF 327
GFH ++ CSP+ CF G C++ + C C PG G HC + + PC
Sbjct: 918 GFHCEQDLPDCSPSSCFNGGTCVDGVN--SFSC-LCRPGY--TGAHCQHEADPCLSRPCL 972
Query: 328 PGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDEC-NDGNNGGCDPNS 386
G C PGF C C + G Q + +D+ S+Q C + C G C P
Sbjct: 973 HGGVCSAAHPGFRC-TCLESFTGPQCQTL-VDW--CSRQPCQNGGRCVQTGAYCLCPPG- 1027
Query: 387 ICTNTVGSFKCGPC---------RLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERN 437
+ + + PC RL L C+ + H +HC E +
Sbjct: 1028 -WSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVD 1086
Query: 438 GAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALP------CMDNNKHCKQDNC 483
++ C G G + GY + LP C D+ C C
Sbjct: 1087 PCLAQPCQHGGTCRGY-------MGGYMCECLPGYNGDNCEDDVDECASQPC 1131
Score = 45.1 bits (105), Expect = 3e-04
Identities = 70/278 (25%), Positives = 90/278 (32%), Gaps = 70/278 (25%)
Query: 321 AHADPCFPGSSCINTMPGFHCE---------ACPRGYKGTQVSGVGIDYARASKQVCNDI 371
A A PC GS C N G C CP G+ G + C
Sbjct: 38 AAAPPCLDGSPCAN---GGRCTQLPSREAACLCPPGWVGER---------------CQLE 79
Query: 372 DECNDGNNGGCDPNSICTNTV----GSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCH 427
D C ++G C +C ++V F C C GF G C C S SPC
Sbjct: 80 DPC---HSGPCAGRGVCQSSVVAGTARFSC-RCPRGFRG---PDCSLPDPCLS---SPCA 129
Query: 428 IHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTP 487
A C +G C C G+ G C +D D + PC CL TP
Sbjct: 130 HGARCSVGPDGRFLCSCPPGYQGRS--CRSDVDECRVGE---PCRHGG------TCLNTP 178
Query: 488 NSGQEDADNDGVGDQCDDDA---------DGDGIKNVED---NCRLFPNKDQQNSDT--- 532
S + G C++ A +G + D +C P + QN +
Sbjct: 179 GSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVD 238
Query: 533 DSFGDACDN---CPNVPNNDQKDTDGNGEGDACDNDVD 567
D G C N C + N G C DVD
Sbjct: 239 DCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVD 276
>gi|10190748 CEGP1 protein [Homo sapiens]
Length = 999
Score = 76.6 bits (187), Expect = 1e-13
Identities = 64/217 (29%), Positives = 88/217 (40%), Gaps = 56/217 (25%)
Query: 298 YRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVG 357
Y+C C PG QG G C DI+EC + C++ C P Y+ T G
Sbjct: 69 YKCS-CKPGYQGEGRQCEDIDECGNE----LNGGCVH-----DCLNIPGNYRCTCFDGFM 118
Query: 358 IDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLG-FLGNQSQGCL--- 413
+ + C D+DEC + NNGGC C N +GS++C C+ G FL + C+
Sbjct: 119 LAH---DGHNCLDVDECLE-NNGGC--QHTCVNVMGSYEC-CCKEGFFLSDNQHTCIHRS 171
Query: 414 -PARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCM 472
+C + H HI C G+V+C+C G+ N
Sbjct: 172 EEGLSCMNKDHGCSHI---CKEAPRGSVACECRPGFELAKN------------------- 209
Query: 473 DNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADG 509
Q +C+LT N G N G CDD ADG
Sbjct: 210 -------QRDCILTCNHG-----NGGCQHSCDDTADG 234
Score = 60.8 bits (146), Expect = 6e-09
Identities = 50/151 (33%), Positives = 62/151 (41%), Gaps = 31/151 (20%)
Query: 331 SCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTN 390
+C +T G HC +CP G+ Q+ G + C DIDEC NGGCD C N
Sbjct: 296 TCKDTSTGVHC-SCPVGFT-LQLDG----------KTCKDIDECQT-RNGGCD--HFCKN 340
Query: 391 TVGSFKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWA 449
VGSF CG C+ GF L + C C S H G +C CN G+
Sbjct: 341 IVGSFDCG-CKKGFKLLTDEKSCQDVDEC-----SLDRTCDHSCINHPGTFACACNRGYT 394
Query: 450 GNGNVCGTDTDIDGYPDQALPCMDNNKHCKQ 480
G DT+ C NN C+Q
Sbjct: 395 LYGFTHCGDTN---------ECSINNGGCQQ 416
Score = 53.1 bits (126), Expect = 1e-06
Identities = 46/138 (33%), Positives = 64/138 (46%), Gaps = 24/138 (17%)
Query: 298 YRCGPCPPG--LQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSG 355
+ CG C G L + C D++EC+ C SCIN F C AC RGY +
Sbjct: 345 FDCG-CKKGFKLLTDEKSCQDVDECSLDRTC--DHSCINHPGTFAC-ACNRGY-----TL 395
Query: 356 VGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQGCLP 414
G + C D +EC+ NNGGC +C NTVGS++C C G+ L + C+
Sbjct: 396 YGFTH-------CGDTNECSI-NNGGCQ--QVCVNTVGSYEC-QCHPGYKLHWNKKDCVE 444
Query: 415 ARTCHSPAHSPCHIHAHC 432
+ + SP + HC
Sbjct: 445 VKGLLPTSVSP-RVSLHC 461
Score = 43.1 bits (100), Expect = 0.001
Identities = 35/117 (29%), Positives = 52/117 (44%), Gaps = 19/117 (16%)
Query: 370 DIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIH 429
D+DEC G + C +++C NT S+KC C+ G+ G Q C C + + C
Sbjct: 45 DVDECAQGLDD-CHADALCQNTPTSYKCS-CKPGYQGEGRQ-CEDIDECGNELNGGC--- 98
Query: 430 AHCLFERNGAVSCQCNVGW--AGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCL 484
H G C C G+ A +G+ C D+D C++NN C Q C+
Sbjct: 99 VHDCLNIPGNYRCTCFDGFMLAHDGHNC---LDVD-------ECLENNGGC-QHTCV 144
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 76.6 bits (187), Expect = 1e-13
Identities = 72/239 (30%), Positives = 98/239 (41%), Gaps = 35/239 (14%)
Query: 298 YRCGPCPPG--LQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSG 355
Y+C CPPG L GT C DI+EC+ +D P C+N + F C +C G++ T
Sbjct: 1094 YKC-QCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQC-SCHAGFQST---- 1147
Query: 356 VGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQGCLP 414
+Q C DI+EC NGGCD + C NT GS++C C G+ L + C
Sbjct: 1148 -------PDRQGCVDINECR-VQNGGCDVH--CINTEGSYRCS-CGQGYSLMPDGRACAD 1196
Query: 415 ARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCM-- 472
C C HC G C C G+ ++ T D+D C+
Sbjct: 1197 VDECEENPR-VCD-QGHCT-NMPGGHRCLCYDGFMATPDM-RTCVDVDECDLNPHICLHG 1252
Query: 473 --DNNK-----HCKQDNCLLTPNSGQEDADNDGV-GDQCDDDADGDGIKNVEDNCRLFP 523
+N K HC+ + +G D D V G CD A I +CR P
Sbjct: 1253 DCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPG-SFSCRCLP 1310
Score = 72.8 bits (177), Expect = 1e-12
Identities = 94/363 (25%), Positives = 129/363 (35%), Gaps = 76/363 (20%)
Query: 274 QRSHCSPNPCFRGVDCMEVYEYPG-YRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSC 332
Q CSP RG DC+ V PG YRC C G G+G C D +ECA C
Sbjct: 1328 QEHRCSP----RG-DCLNV---PGSYRC-TCRQGFAGDGFFCEDRDECAENVDLCDNGQC 1378
Query: 333 INTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTV 392
+N G+ CE C G+ T+ + C D+DEC GN C S C N
Sbjct: 1379 LNAPGGYRCE-CEMGFDPTE-----------DHRACQDVDECAQGNL--CAFGS-CENLP 1423
Query: 393 GSFKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGN 451
G F+C C G+ L C C P + I+ C+ G+ C C + N
Sbjct: 1424 GMFRC-ICNGGYELDRGGGNCTDINECADPVNC---INGVCI-NTPGSYLCSCPQDFELN 1478
Query: 452 GNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDG 511
+ G C+D + NC L E D G C + G G
Sbjct: 1479 PSGVG--------------CVDT----RAGNCFL------ETHDRGDSGISCSAEI-GVG 1513
Query: 512 IKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGI 571
+ C L ++G+ C+ CP + + GEG + I
Sbjct: 1514 VTRASCCCSL----------GRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRIT---VI 1560
Query: 572 PNGLDNCPKVPNPLQTDRDEDGVGDACDSCP---EMSNPTQTDADSDLVGDVCDTNEDSD 628
+D C ++P Q + G CP +S T+ D D C T+
Sbjct: 1561 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDI----DECSTHSGIC 1616
Query: 629 GDG 631
G G
Sbjct: 1617 GPG 1619
Score = 65.5 bits (158), Expect = 2e-10
Identities = 61/185 (32%), Positives = 83/185 (44%), Gaps = 32/185 (17%)
Query: 298 YRCGPCPPGL-QGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGV 356
YRC C G Q C D++EC + PC G C+N +HC P G++ T
Sbjct: 431 YRC-ECNVGYTQDVRGECIDVDECT-SSPCHHGD-CVNIPGTYHCRCYP-GFQATP---- 482
Query: 357 GIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQGCLPA 415
++Q C D+DEC +GG C NT GSF+C C GF L + C+
Sbjct: 483 -------TRQACVDVDECI--VSGGLCHLGRCVNTEGSFQC-VCNAGFELSPDGKNCVDH 532
Query: 416 RTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGW--AGNGNVCGTDTDIDGYPDQALPCMD 473
C A S ++ CL E +G+ SC C G+ A G+ C DID + P +
Sbjct: 533 NEC---ATSTMCVNGVCLNE-DGSFSCLCKPGFLLAPGGHYC---MDID---ECQTPGIC 582
Query: 474 NNKHC 478
N HC
Sbjct: 583 VNGHC 587
Score = 65.1 bits (157), Expect = 3e-10
Identities = 42/110 (38%), Positives = 51/110 (46%), Gaps = 19/110 (17%)
Query: 297 GYRCGPCPPGLQGNG--THCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVS 354
GYRC CP G + C D NECA + P +SC NT+ GF C CP G+ Q
Sbjct: 2548 GYRCS-CPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRC-VCPSGFDFDQAL 2605
Query: 355 GVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF 404
G C ++DEC G G C + C NT G F CG C G+
Sbjct: 2606 G-----------GCQEVDEC-AGRRGPCSYS--CANTPGGFLCG-CPQGY 2640
Score = 64.3 bits (155), Expect = 5e-10
Identities = 58/210 (27%), Positives = 83/210 (39%), Gaps = 43/210 (20%)
Query: 273 EQRSHCSPNP--CFRGVDCMEVYEYPGYRCGPCPPG--LQGNGTHCSDINECAHADPCFP 328
E + C+ NP C GV C+ +RC CP G L G +C D +EC+ PC
Sbjct: 2083 EDVNECAENPGVCTNGV-CVNTDG--SFRC-ECPFGYSLDFTGINCVDTDECSVGHPCGQ 2138
Query: 329 GSSCINTMPGFHCEACPRGYK-GTQVSGVGIDYA-------------------------- 361
G+ C N + GF C AC G++ G ++ ID
Sbjct: 2139 GT-CTNVIGGFEC-ACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGY 2196
Query: 362 --RASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKC-GPCRLGFLGNQSQGCLPARTC 418
R +C D+DEC DG C N +G+F C P + L +GC C
Sbjct: 2197 TLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNEC 2256
Query: 419 HSPAHSPCHIHAHCLFERNGAVSCQCNVGW 448
H A ++ C+ G+ C C+ G+
Sbjct: 2257 H--AQPDLCVNGRCV-NTAGSFRCDCDEGF 2283
Score = 63.5 bits (153), Expect = 9e-10
Identities = 51/215 (23%), Positives = 78/215 (36%), Gaps = 51/215 (23%)
Query: 307 LQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQ 366
L +C+DI+EC + +C+NT F CE P G + +D ++
Sbjct: 1019 LDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARD 1078
Query: 367 -------------------------------VCNDIDECNDGNNGGCDPNSICTNTVGSF 395
C DIDEC+ + G P+ C N +G+F
Sbjct: 1079 PLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECS--LSDGLCPHGQCVNVIGAF 1136
Query: 396 KCGPCRLGFLGN-QSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWA--GNG 452
+C C GF QGC+ C + C +H G+ C C G++ +G
Sbjct: 1137 QCS-CHAGFQSTPDRQGCVDINECR-VQNGGCDVHC---INTEGSYRCSCGQGYSLMPDG 1191
Query: 453 NVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTP 487
C D+D C +N + C Q +C P
Sbjct: 1192 RAC---ADVD-------ECEENPRVCDQGHCTNMP 1216
Score = 61.6 bits (148), Expect = 3e-09
Identities = 90/367 (24%), Positives = 127/367 (34%), Gaps = 80/367 (21%)
Query: 280 PNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGT--HCSDINEC-AHADPCFPGSSCINTM 336
P C G+ C+ + +RC CP G N C D++EC + PC + CIN
Sbjct: 1729 PAICANGI-CIN--QIGSFRC-ECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIP 1784
Query: 337 PGFHCEACPRGYK--------------------------GTQVSGVGIDY----ARASKQ 366
+ C+ C RGYK T+ S + + + A A +
Sbjct: 1785 GSYRCK-CTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQT 1843
Query: 367 VCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPC 426
+C DIDEC+ G N C N +GS+ C C GF+ + C+ C + C
Sbjct: 1844 LCMDIDECDRQPCG----NGTCKNIIGSYNC-LCFPGFVVTHNGDCVDFDECTTLVGQVC 1898
Query: 427 HIHAHCLFERNGAVSCQCNVGW--AGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCL 484
HCL G+ C C G+ +G C + LP N C+
Sbjct: 1899 RF-GHCL-NTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLE-GSFRCI 1955
Query: 485 LTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPN 544
P + D C D D C PN + T+S G CP
Sbjct: 1956 CPPGFQVQ-------SDHCID----------IDECSEEPNLCLFGTCTNSPGSFQCLCP- 1997
Query: 545 VPNNDQKDTDGNGEGDACDNDVDG---DGIPNGLDNCPKVPNPLQT-----DRDEDGVGD 596
P D G C + G + PK N +T R +G GD
Sbjct: 1998 -PGFVLSD-----NGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGD 2051
Query: 597 ACDSCPE 603
C+ CP+
Sbjct: 2052 PCELCPQ 2058
Score = 60.8 bits (146), Expect = 6e-09
Identities = 61/213 (28%), Positives = 77/213 (36%), Gaps = 36/213 (16%)
Query: 303 CPPG---LQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGID 359
CP G + G D+NECA C+NT F CE CP GY + GI+
Sbjct: 2068 CPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCE-CPFGY---SLDFTGIN 2123
Query: 360 YARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCH 419
C D DEC+ G+ G CTN +G F+C C GF C C
Sbjct: 2124 --------CVDTDECSVGHPCG---QGTCTNVIGGFECA-CADGFEPGLMMTCEDIDEC- 2170
Query: 420 SPAHSPCHIHAHCLFERNGAVSCQCNVGWA--GNGNVCGTDTDIDGYPDQALPCMDNNKH 477
S C H G+ C C G+ +G +C D+D D C
Sbjct: 2171 SLNPLLCAFRCH---NTEGSYLCTCPAGYTLREDGAMC---RDVDECADGQQDCHARGME 2224
Query: 478 CKQ----DNCLLTPNSGQEDADNDGVGDQCDDD 506
CK C+ P G G+ C DD
Sbjct: 2225 CKNLIGTFACVCPPGM----RPLPGSGEGCTDD 2253
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/178 (28%), Positives = 70/178 (39%), Gaps = 30/178 (16%)
Query: 316 DINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECN 375
DI+EC CIN + F CE CP G+ + C D+DEC
Sbjct: 1721 DIDECGEIPAICANGICINQIGSFRCE-CPAGFNYNSI-----------LLACEDVDECG 1768
Query: 376 DGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFE 435
C N+ C N GS++C C G+ + C+ C + C H C+ +
Sbjct: 1769 -SRESPCQQNADCINIPGSYRC-KCTRGYKLSPGGACVGRNECRE-IPNVCS-HGDCM-D 1823
Query: 436 RNGAVSCQCNVGWAGNGN--VCGTDTDIDGYPDQALPCMDNNKHCK----QDNCLLTP 487
G+ C C+ G+ + + +C DID Q PC N CK NCL P
Sbjct: 1824 TEGSYMCLCHRGFQASADQTLC---MDIDECDRQ--PC--GNGTCKNIIGSYNCLCFP 1874
Score = 54.3 bits (129), Expect = 5e-07
Identities = 59/239 (24%), Positives = 85/239 (35%), Gaps = 43/239 (17%)
Query: 297 GYRCGPCP-PGLQGNGTHCS----------DINECAHADPCFPGSSCINTMPGFHCEACP 345
G RC CP PG C D++EC CIN++ F C C
Sbjct: 2333 GPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCH-CQ 2391
Query: 346 RGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFL 405
GY A+ C D+DEC+ C +C NT GSF C R L
Sbjct: 2392 AGYTPD-----------ATATTCLDMDECSQVPKP-C--TFLCKNTKGSFLCSCPRGYLL 2437
Query: 406 GNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYP 465
+ C C S H+ + + + GA +C+C G+ + C + + P
Sbjct: 2438 EEDGRTCKDLDECTSRQHNCQFLCVNTV----GAFTCRCPPGFTQHHQACFDNDECSAQP 2493
Query: 466 DQALPCMDNNKHCKQDNCLLTPNSGQEDADND----GVGDQCDDDADGDGIKNVEDNCR 520
PC + HC TP S + + G C+D + DG + C+
Sbjct: 2494 G---PC-GAHGHCHN-----TPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQ 2543
Score = 51.2 bits (121), Expect = 5e-06
Identities = 43/153 (28%), Positives = 58/153 (37%), Gaps = 42/153 (27%)
Query: 278 CSPNPCFRGVDCMEVYEYPG-YRCGPCPPGLQGNGTH--CSDINECAHADPCFPGSSCIN 334
C+ +PC G DC+ + PG Y C C PG Q T C D++EC + C+N
Sbjct: 453 CTSSPCHHG-DCVNI---PGTYHCR-CYPGFQATPTRQACVDVDECIVSGGLCHLGRCVN 507
Query: 335 TMPGFHCEACPRGYKGTQVSGVGIDYARASKQV--------------------------- 367
T F C C G++ + +D+ +
Sbjct: 508 TEGSFQC-VCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPG 566
Query: 368 ---CNDIDECNDGNNGGCDPNSICTNTVGSFKC 397
C DIDEC G N CTNT GSF+C
Sbjct: 567 GHYCMDIDECQ---TPGICVNGHCTNTEGSFRC 596
Score = 49.3 bits (116), Expect = 2e-05
Identities = 50/148 (33%), Positives = 63/148 (42%), Gaps = 26/148 (17%)
Query: 303 CPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYAR 362
C GL G T DINECA C N + C C GY+ A
Sbjct: 670 CSSGL-GITTDGRDINECALDPEVCANGVCENLRGSYRC-VCNLGYE-----------AG 716
Query: 363 ASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTCHSP 421
AS + C D+DEC N+ CD N C N+ GS+ C C GF ++ C C S
Sbjct: 717 ASGKDCTDVDEC-ALNSLLCD-NGWCQNSPGSYSCS-CPPGFHFWQDTEICKDVDECLS- 772
Query: 422 AHSPCHIHAHCLFERN--GAVSCQCNVG 447
SPC + C RN G+ +C+C G
Sbjct: 773 --SPC-VSGVC---RNLAGSYTCKCGPG 794
Score = 48.1 bits (113), Expect = 4e-05
Identities = 67/252 (26%), Positives = 95/252 (37%), Gaps = 56/252 (22%)
Query: 252 QVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPG--LQG 309
Q +++I I ECQ P C +G DC+ + ++C CPPG L
Sbjct: 1553 QPNRITVILEDIDECQEL----------PGLC-QGGDCVNTFG--SFQC-ECPPGYHLSE 1598
Query: 310 NGTHCSDINECA-HADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVC 368
+ C DI+EC+ H+ C PG +C NT+ + C CP Y QV+G G + K V
Sbjct: 1599 HTRICEDIDECSTHSGICGPG-TCYNTLGNYTC-VCPAEY--LQVNG-GNNCMDMRKSV- 1652
Query: 369 NDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLG--------------------FLGNQ 408
C NG C N + N C +G GNQ
Sbjct: 1653 -----CFRHYNGTCQ-NELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQ 1706
Query: 409 SQGCLPARTCHSPAH-SPC-HIHAHC----LFERNGAVSCQCNVGWAGNGNVCGTDTDID 462
+ G L P C I A C + G+ C+C G+ N + + D+D
Sbjct: 1707 APGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACE-DVD 1765
Query: 463 GYPDQALPCMDN 474
+ PC N
Sbjct: 1766 ECGSRESPCQQN 1777
Score = 46.6 bits (109), Expect = 1e-04
Identities = 53/209 (25%), Positives = 76/209 (36%), Gaps = 35/209 (16%)
Query: 285 RGVDCMEVYEYPGYRCGPCPPGLQ---GNGTHCSDINEC-AHADPCFPGSSCINTMPGFH 340
RG++C + G CPPG++ G+G C+D NEC A D C G C+NT F
Sbjct: 2221 RGMECKNLI---GTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG-RCVNTAGSFR 2276
Query: 341 CEACPRGYKG----TQVSGV--GIDYARASKQVCNDID---------ECNDGNNGGCDPN 385
C+ C G++ T+ + G +A + +C + EC G G P
Sbjct: 2277 CD-CDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPR 2335
Query: 386 -SIC--TNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSC 442
+C T K P G+ H AH C G+ C
Sbjct: 2336 CELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGEC-------INSLGSFRC 2388
Query: 443 QCNVGWAGNGNVCGTDTDIDGYPDQALPC 471
C G+ + T D+D PC
Sbjct: 2389 HCQAGYTPDATAT-TCLDMDECSQVPKPC 2416
Score = 45.8 bits (107), Expect = 2e-04
Identities = 38/124 (30%), Positives = 55/124 (44%), Gaps = 24/124 (19%)
Query: 280 PNPCFRGVDCMEVYEYPGYRCGPCPPGLQG--NGTHCSDINECAHADPCFPGSSCINTMP 337
P C GV C + YRC C G + +G C+D++ECA C N+ P
Sbjct: 690 PEVCANGV-CENLRG--SYRC-VCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNS-P 744
Query: 338 GFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSF-- 395
G + +CP G+ Q ++C D+DEC + C + +C N GS+
Sbjct: 745 GSYSCSCPPGFHFWQ-----------DTEICKDVDEC---LSSPC-VSGVCRNLAGSYTC 789
Query: 396 KCGP 399
KCGP
Sbjct: 790 KCGP 793
Score = 44.3 bits (103), Expect = 6e-04
Identities = 66/252 (26%), Positives = 85/252 (33%), Gaps = 44/252 (17%)
Query: 269 CGFHEQRSHCSPN---PCFRGVDCMEVYEYPGYRCGPC---PPGLQG----NGTHCSDIN 318
C Q S C N R C + G C C P +G G C D+N
Sbjct: 812 CWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVN 871
Query: 319 ECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGN 378
EC P C+NT F CE CP G + +D + D DEC
Sbjct: 872 ECESFPGVCPNGRCVNTAGSFRCE-CPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTL 930
Query: 379 NGGCDPNSICTN--TVGSFKCGPC----RLGF-------LGNQSQGCLPARTCHSPAHSP 425
G + C + V +C C L F LG S+ L R + +
Sbjct: 931 PGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNE- 989
Query: 426 CHI------HAHCLFERN--GAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKH 477
C + H C RN G+ C C G+A + TDID C +
Sbjct: 990 CKVFPGLCTHGTC---RNTVGSFHCACAGGFALDAQERNC-TDID-------ECRISPDL 1038
Query: 478 CKQDNCLLTPNS 489
C Q C+ TP S
Sbjct: 1039 CGQGTCVNTPGS 1050
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/87 (29%), Positives = 37/87 (42%), Gaps = 10/87 (11%)
Query: 283 CFRGVDCMEVYEYPGYRCGPCP----PGLQG-----NGTHCSDINECAHADPCFPGSSCI 333
C + + C V G C CP P +G + C D++EC G SC+
Sbjct: 205 CTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCV 264
Query: 334 NTMPGFHCEACPRGYKGTQVSGVGIDY 360
N + FHC CP G++ + S DY
Sbjct: 265 NMVGSFHCR-CPVGHRLSDSSAACEDY 290
Score = 37.7 bits (86), Expect = 0.052
Identities = 48/163 (29%), Positives = 55/163 (33%), Gaps = 49/163 (30%)
Query: 270 GFHEQRSHCSPNPC-----FRGVDCMEVYEYPGYRCGPC-----PPGLQGN--GTHCSDI 317
G H PN C F G C YR GPC P G Q G C+
Sbjct: 154 GCHNGGRCIGPNRCACVYGFMGPQCER-----DYRTGPCFGQVGPEGCQHQLTGLVCTKA 208
Query: 318 NECAHADPCFPGSSCINTMPGFHCEACP-------RGYKGTQVSGVGIDYARASKQVCND 370
CA + G CE CP RG+ +G C D
Sbjct: 209 LCCATVGRAW----------GLPCELCPAQPHPCRRGFIPNIHTGA-----------CQD 247
Query: 371 IDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQGC 412
+DEC G C S C N VGSF C C +G L + S C
Sbjct: 248 VDECQ-AVPGLCQGGS-CVNMVGSFHC-RCPVGHRLSDSSAAC 287
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 76.6 bits (187), Expect = 1e-13
Identities = 63/224 (28%), Positives = 85/224 (37%), Gaps = 43/224 (19%)
Query: 284 FRGVDCMEVYEYPGYR---CGP-------------CPPGLQ--GNGTHCSDINECAHADP 325
FRG C E + CGP CP G + G G C D++ECA + P
Sbjct: 635 FRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPP 694
Query: 326 CFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPN 385
C NT F C CP G++ + C D+DEC N+ C P
Sbjct: 695 PCTYGRCENTEGSFQC-VCPMGFQ-----------PNTAGSECEDVDECE--NHLAC-PG 739
Query: 386 SICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCN 445
C N+ GSF+C C G ++ + C C S A PC H HC G+ C C
Sbjct: 740 QECVNSPGSFQCRTCPSGHHLHRGR-CTDVDECSSGA-PPCGPHGHCT-NTEGSFRCSCA 796
Query: 446 VGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNS 489
G+ G D++ C++ + CL T S
Sbjct: 797 PGYRAPSGRPGPCADVN-------ECLEGDFCFPHGECLNTDGS 833
Score = 68.9 bits (167), Expect = 2e-11
Identities = 84/315 (26%), Positives = 111/315 (35%), Gaps = 69/315 (21%)
Query: 265 ECQVC--GFHEQRSHCSP--------NPCFRGVDCMEVYEYPGYRCGPCPPGLQ---GNG 311
+C+ C G H R C+ PC C +RC C PG + G
Sbjct: 750 QCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEG--SFRCS-CAPGYRAPSGRP 806
Query: 312 THCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDI 371
C+D+NEC D CFP C+NT F C P G + + C D+
Sbjct: 807 GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGAS------------CLDV 854
Query: 372 DECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHA 430
DEC++ + + ICTNT GSF+C C G G CL C P +
Sbjct: 855 DECSEED---LCQSGICTNTDGSFEC-ICPPGHRAGPDLASCLDVDECRE--RGPALCGS 908
Query: 431 HCLFERNGAVSC--QCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKH-CKQDNCLLTP 487
G+ C C+ G+ GT D+D C + C C TP
Sbjct: 909 QRCENSPGSYRCVRDCDPGYHAGPE--GTCDDVD-------ECQEYGPEICGAQRCENTP 959
Query: 488 NSGQEDADNDGVGDQCD---DDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPN 544
S + CD G G ++V D CR SF A C N
Sbjct: 960 GSYR-------CTPACDPGYQPTPGGGCQDV-DECR-----------NRSFCGAHAVCQN 1000
Query: 545 VPNNDQKDTDGNGEG 559
+P + Q D EG
Sbjct: 1001 LPGSFQCLCDQGYEG 1015
Score = 52.4 bits (124), Expect = 2e-06
Identities = 56/198 (28%), Positives = 73/198 (36%), Gaps = 36/198 (18%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPG--LQGNGTHCSDINECAHA-DPCFPGSSCIN 334
C P C + GY C C G L GT C D++EC PC PG C N
Sbjct: 489 CGPGRC--------ISRPSGYTCA-CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCEN 538
Query: 335 TMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGS 394
+ F C C G++ RA++ C D+DEC+ CD C NT GS
Sbjct: 539 SPGSFRC-VCGPGFRAG---------PRAAE--CLDVDECH-RVPPPCDLGR-CENTPGS 584
Query: 395 FKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGN 453
F C C G+ C C SP G+ C C G+ G+
Sbjct: 585 FLC-VCPAGYQAAPHGASCQDVDEC---TQSPGLCGRGACKNLPGSFRCVCPAGFRGS-- 638
Query: 454 VCGTDTDIDGYPDQALPC 471
+ D+D + PC
Sbjct: 639 --ACEEDVDECAQEPPPC 654
Score = 49.3 bits (116), Expect = 2e-05
Identities = 88/357 (24%), Positives = 122/357 (34%), Gaps = 70/357 (19%)
Query: 326 CFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPN 385
C PG CI+ G+ C AC G++ +S G C D+DEC C P
Sbjct: 489 CGPGR-CISRPSGYTC-ACDSGFR---LSPQGTR--------CIDVDECRRVPPP-CAPG 534
Query: 386 SICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQC 444
C N+ GSF+C C GF G ++ CL CH PC + C G+ C C
Sbjct: 535 R-CENSPGSFRC-VCGPGFRAGPRAAECLDVDECHR-VPPPCDL-GRCE-NTPGSFLCVC 589
Query: 445 NVGW--AGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQ 502
G+ A +G C D+D C + C + C P S + G
Sbjct: 590 PAGYQAAPHGASC---QDVD-------ECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSA 639
Query: 503 CDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDAC 562
C++D D C P ++ G CP G G C
Sbjct: 640 CEEDVD---------ECAQEPPPCGPGRCDNTAGSFHCACP-------AGFRSRGPGAPC 683
Query: 563 DNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCD 622
+ +D C + P P R E+ G CP P ++ + V D C+
Sbjct: 684 QD----------VDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDV-DECE 732
Query: 623 TNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDG----LGDECDGDDDNDGIPDYVPPG 675
+ G C P S Q + G G D D+ + G P P G
Sbjct: 733 NHLACPG-------QECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHG 782
Score = 45.8 bits (107), Expect = 2e-04
Identities = 37/104 (35%), Positives = 48/104 (46%), Gaps = 18/104 (17%)
Query: 316 DINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECN 375
+ EC D C G C+ GF C C GY+ +D R + C DI+EC+
Sbjct: 1466 EAEECGILDGCTNGR-CVRVPEGFTCR-CFDGYR--------LDMTRMA---CVDINECD 1512
Query: 376 DGNNGG--CDPNSICTNTVGSFKCGPCRLGFL-GNQSQGCLPAR 416
+ C N+ C NT GSF+C CR GF +Q C PAR
Sbjct: 1513 EAEAASPLC-VNARCLNTDGSFRC-ICRPGFAPTHQPHHCAPAR 1554
Score = 43.9 bits (102), Expect = 7e-04
Identities = 28/83 (33%), Positives = 35/83 (42%), Gaps = 15/83 (18%)
Query: 316 DINECA-HADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDEC 374
D++EC D C+NT PG+ C C GY Y + C D DEC
Sbjct: 1186 DVDECQLFRDQVCKSGVCVNTAPGYSC-YCSNGY-----------YYHTQRLECIDNDEC 1233
Query: 375 NDGNNGGCDPNSICTNTVGSFKC 397
D C+ C NTVGS+ C
Sbjct: 1234 AD-EEPACE-GGRCVNTVGSYHC 1254
Score = 43.5 bits (101), Expect = 0.001
Identities = 20/48 (41%), Positives = 25/48 (52%), Gaps = 2/48 (4%)
Query: 301 GPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGY 348
GPCP G + C D++ECA C G C NT G+ C CP G+
Sbjct: 275 GPCPTGFERVNGSCEDVDECATGGRCQHG-ECANTRGGYTC-VCPDGF 320
Score = 40.4 bits (93), Expect = 0.008
Identities = 28/89 (31%), Positives = 37/89 (41%), Gaps = 15/89 (16%)
Query: 259 IRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGL--QGNGTHCSD 316
+R + ECQ+ F +Q C C V PGY C C G C D
Sbjct: 1183 LRRDVDECQL--FRDQV--CKSGVC--------VNTAPGYSCY-CSNGYYYHTQRLECID 1229
Query: 317 INECAHADPCFPGSSCINTMPGFHCEACP 345
+ECA +P G C+NT+ +HC P
Sbjct: 1230 NDECADEEPACEGGRCVNTVGSYHCTCEP 1258
Score = 38.1 bits (87), Expect = 0.040
Identities = 39/150 (26%), Positives = 54/150 (36%), Gaps = 35/150 (23%)
Query: 283 CFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSD------INECAHADPCFPGSSCINTM 336
CFR E G C PGL+ C +++C S ++
Sbjct: 222 CFR--------ELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAP 273
Query: 337 PGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFK 396
G CP G++ S C D+DEC G G C + C NT G +
Sbjct: 274 DG----PCPTGFERVNGS-------------CEDVDECATG--GRCQ-HGECANTRGGYT 313
Query: 397 CGPCRLGFLGNQSQGCLPARTCHSPAHSPC 426
C C GFL + S+ ++ S A PC
Sbjct: 314 C-VCPDGFLLDSSRSSCISQHVISEAKGPC 342
Score = 33.1 bits (74), Expect = 1.3
Identities = 26/91 (28%), Positives = 36/91 (39%), Gaps = 14/91 (15%)
Query: 264 MECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHA 323
+E + CG + C+ C R + + GYR L C DINEC A
Sbjct: 1465 LEAEECGILDG---CTNGRCVRVPEGFTCRCFDGYR-------LDMTRMACVDINECDEA 1514
Query: 324 DPCFP---GSSCINTMPGFHCEACPRGYKGT 351
+ P + C+NT F C C G+ T
Sbjct: 1515 EAASPLCVNARCLNTDGSFRC-ICRPGFAPT 1544
Score = 31.2 bits (69), Expect = 4.8
Identities = 16/45 (35%), Positives = 20/45 (44%), Gaps = 3/45 (6%)
Query: 303 CPPGLQG--NGTHCSDINECAHADPCFPGSSCINTMPGFHCEACP 345
C G +G +G HC D+NEC + C N F C CP
Sbjct: 1009 CDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLC-VCP 1052
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 76.6 bits (187), Expect = 1e-13
Identities = 63/224 (28%), Positives = 85/224 (37%), Gaps = 43/224 (19%)
Query: 284 FRGVDCMEVYEYPGYR---CGP-------------CPPGLQ--GNGTHCSDINECAHADP 325
FRG C E + CGP CP G + G G C D++ECA + P
Sbjct: 665 FRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPP 724
Query: 326 CFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPN 385
C NT F C CP G++ + C D+DEC N+ C P
Sbjct: 725 PCTYGRCENTEGSFQC-VCPMGFQ-----------PNTAGSECEDVDECE--NHLAC-PG 769
Query: 386 SICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCN 445
C N+ GSF+C C G ++ + C C S A PC H HC G+ C C
Sbjct: 770 QECVNSPGSFQCRTCPSGHHLHRGR-CTDVDECSSGA-PPCGPHGHCT-NTEGSFRCSCA 826
Query: 446 VGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNS 489
G+ G D++ C++ + CL T S
Sbjct: 827 PGYRAPSGRPGPCADVN-------ECLEGDFCFPHGECLNTDGS 863
Score = 68.9 bits (167), Expect = 2e-11
Identities = 84/315 (26%), Positives = 111/315 (35%), Gaps = 69/315 (21%)
Query: 265 ECQVC--GFHEQRSHCSP--------NPCFRGVDCMEVYEYPGYRCGPCPPGLQ---GNG 311
+C+ C G H R C+ PC C +RC C PG + G
Sbjct: 780 QCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEG--SFRCS-CAPGYRAPSGRP 836
Query: 312 THCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDI 371
C+D+NEC D CFP C+NT F C P G + + C D+
Sbjct: 837 GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGAS------------CLDV 884
Query: 372 DECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHA 430
DEC++ + + ICTNT GSF+C C G G CL C P +
Sbjct: 885 DECSEED---LCQSGICTNTDGSFEC-ICPPGHRAGPDLASCLDVDECRE--RGPALCGS 938
Query: 431 HCLFERNGAVSC--QCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKH-CKQDNCLLTP 487
G+ C C+ G+ GT D+D C + C C TP
Sbjct: 939 QRCENSPGSYRCVRDCDPGYHAGPE--GTCDDVD-------ECQEYGPEICGAQRCENTP 989
Query: 488 NSGQEDADNDGVGDQCD---DDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPN 544
S + CD G G ++V D CR SF A C N
Sbjct: 990 GSYR-------CTPACDPGYQPTPGGGCQDV-DECR-----------NRSFCGAHAVCQN 1030
Query: 545 VPNNDQKDTDGNGEG 559
+P + Q D EG
Sbjct: 1031 LPGSFQCLCDQGYEG 1045
Score = 52.4 bits (124), Expect = 2e-06
Identities = 56/198 (28%), Positives = 73/198 (36%), Gaps = 36/198 (18%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPG--LQGNGTHCSDINECAHA-DPCFPGSSCIN 334
C P C + GY C C G L GT C D++EC PC PG C N
Sbjct: 519 CGPGRC--------ISRPSGYTCA-CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCEN 568
Query: 335 TMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGS 394
+ F C C G++ RA++ C D+DEC+ CD C NT GS
Sbjct: 569 SPGSFRC-VCGPGFRAG---------PRAAE--CLDVDECH-RVPPPCDLGR-CENTPGS 614
Query: 395 FKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGN 453
F C C G+ C C SP G+ C C G+ G+
Sbjct: 615 FLC-VCPAGYQAAPHGASCQDVDEC---TQSPGLCGRGACKNLPGSFRCVCPAGFRGS-- 668
Query: 454 VCGTDTDIDGYPDQALPC 471
+ D+D + PC
Sbjct: 669 --ACEEDVDECAQEPPPC 684
Score = 49.3 bits (116), Expect = 2e-05
Identities = 88/357 (24%), Positives = 122/357 (34%), Gaps = 70/357 (19%)
Query: 326 CFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPN 385
C PG CI+ G+ C AC G++ +S G C D+DEC C P
Sbjct: 519 CGPGR-CISRPSGYTC-ACDSGFR---LSPQGTR--------CIDVDECRRVPPP-CAPG 564
Query: 386 SICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQC 444
C N+ GSF+C C GF G ++ CL CH PC + C G+ C C
Sbjct: 565 R-CENSPGSFRC-VCGPGFRAGPRAAECLDVDECHR-VPPPCDL-GRCE-NTPGSFLCVC 619
Query: 445 NVGW--AGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQ 502
G+ A +G C D+D C + C + C P S + G
Sbjct: 620 PAGYQAAPHGASC---QDVD-------ECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSA 669
Query: 503 CDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDAC 562
C++D D C P ++ G CP G G C
Sbjct: 670 CEEDVD---------ECAQEPPPCGPGRCDNTAGSFHCACP-------AGFRSRGPGAPC 713
Query: 563 DNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCD 622
+ +D C + P P R E+ G CP P ++ + V D C+
Sbjct: 714 QD----------VDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDV-DECE 762
Query: 623 TNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDG----LGDECDGDDDNDGIPDYVPPG 675
+ G C P S Q + G G D D+ + G P P G
Sbjct: 763 NHLACPG-------QECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHG 812
Score = 45.8 bits (107), Expect = 2e-04
Identities = 37/104 (35%), Positives = 48/104 (46%), Gaps = 18/104 (17%)
Query: 316 DINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECN 375
+ EC D C G C+ GF C C GY+ +D R + C DI+EC+
Sbjct: 1496 EAEECGILDGCTNGR-CVRVPEGFTCR-CFDGYR--------LDMTRMA---CVDINECD 1542
Query: 376 DGNNGG--CDPNSICTNTVGSFKCGPCRLGFL-GNQSQGCLPAR 416
+ C N+ C NT GSF+C CR GF +Q C PAR
Sbjct: 1543 EAEAASPLC-VNARCLNTDGSFRC-ICRPGFAPTHQPHHCAPAR 1584
Score = 43.9 bits (102), Expect = 7e-04
Identities = 28/83 (33%), Positives = 35/83 (42%), Gaps = 15/83 (18%)
Query: 316 DINECA-HADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDEC 374
D++EC D C+NT PG+ C C GY Y + C D DEC
Sbjct: 1216 DVDECQLFRDQVCKSGVCVNTAPGYSC-YCSNGY-----------YYHTQRLECIDNDEC 1263
Query: 375 NDGNNGGCDPNSICTNTVGSFKC 397
D C+ C NTVGS+ C
Sbjct: 1264 AD-EEPACE-GGRCVNTVGSYHC 1284
Score = 43.5 bits (101), Expect = 0.001
Identities = 20/48 (41%), Positives = 25/48 (52%), Gaps = 2/48 (4%)
Query: 301 GPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGY 348
GPCP G + C D++ECA C G C NT G+ C CP G+
Sbjct: 305 GPCPTGFERVNGSCEDVDECATGGRCQHG-ECANTRGGYTC-VCPDGF 350
Score = 40.4 bits (93), Expect = 0.008
Identities = 28/89 (31%), Positives = 37/89 (41%), Gaps = 15/89 (16%)
Query: 259 IRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGL--QGNGTHCSD 316
+R + ECQ+ F +Q C C V PGY C C G C D
Sbjct: 1213 LRRDVDECQL--FRDQV--CKSGVC--------VNTAPGYSCY-CSNGYYYHTQRLECID 1259
Query: 317 INECAHADPCFPGSSCINTMPGFHCEACP 345
+ECA +P G C+NT+ +HC P
Sbjct: 1260 NDECADEEPACEGGRCVNTVGSYHCTCEP 1288
Score = 38.1 bits (87), Expect = 0.040
Identities = 39/150 (26%), Positives = 54/150 (36%), Gaps = 35/150 (23%)
Query: 283 CFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSD------INECAHADPCFPGSSCINTM 336
CFR E G C PGL+ C +++C S ++
Sbjct: 252 CFR--------ELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAP 303
Query: 337 PGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFK 396
G CP G++ S C D+DEC G G C + C NT G +
Sbjct: 304 DG----PCPTGFERVNGS-------------CEDVDECATG--GRCQ-HGECANTRGGYT 343
Query: 397 CGPCRLGFLGNQSQGCLPARTCHSPAHSPC 426
C C GFL + S+ ++ S A PC
Sbjct: 344 C-VCPDGFLLDSSRSSCISQHVISEAKGPC 372
Score = 33.1 bits (74), Expect = 1.3
Identities = 26/91 (28%), Positives = 36/91 (39%), Gaps = 14/91 (15%)
Query: 264 MECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHA 323
+E + CG + C+ C R + + GYR L C DINEC A
Sbjct: 1495 LEAEECGILDG---CTNGRCVRVPEGFTCRCFDGYR-------LDMTRMACVDINECDEA 1544
Query: 324 DPCFP---GSSCINTMPGFHCEACPRGYKGT 351
+ P + C+NT F C C G+ T
Sbjct: 1545 EAASPLCVNARCLNTDGSFRC-ICRPGFAPT 1574
Score = 31.2 bits (69), Expect = 4.8
Identities = 16/45 (35%), Positives = 20/45 (44%), Gaps = 3/45 (6%)
Query: 303 CPPGLQG--NGTHCSDINECAHADPCFPGSSCINTMPGFHCEACP 345
C G +G +G HC D+NEC + C N F C CP
Sbjct: 1039 CDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLC-VCP 1082
>gi|110347431 latent transforming growth factor beta binding protein
4 isoform a [Homo sapiens]
Length = 1624
Score = 76.6 bits (187), Expect = 1e-13
Identities = 63/224 (28%), Positives = 85/224 (37%), Gaps = 43/224 (19%)
Query: 284 FRGVDCMEVYEYPGYR---CGP-------------CPPGLQ--GNGTHCSDINECAHADP 325
FRG C E + CGP CP G + G G C D++ECA + P
Sbjct: 702 FRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPP 761
Query: 326 CFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPN 385
C NT F C CP G++ + C D+DEC N+ C P
Sbjct: 762 PCTYGRCENTEGSFQC-VCPMGFQ-----------PNTAGSECEDVDECE--NHLAC-PG 806
Query: 386 SICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCN 445
C N+ GSF+C C G ++ + C C S A PC H HC G+ C C
Sbjct: 807 QECVNSPGSFQCRTCPSGHHLHRGR-CTDVDECSSGA-PPCGPHGHCT-NTEGSFRCSCA 863
Query: 446 VGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNS 489
G+ G D++ C++ + CL T S
Sbjct: 864 PGYRAPSGRPGPCADVN-------ECLEGDFCFPHGECLNTDGS 900
Score = 68.9 bits (167), Expect = 2e-11
Identities = 84/315 (26%), Positives = 111/315 (35%), Gaps = 69/315 (21%)
Query: 265 ECQVC--GFHEQRSHCSP--------NPCFRGVDCMEVYEYPGYRCGPCPPGLQ---GNG 311
+C+ C G H R C+ PC C +RC C PG + G
Sbjct: 817 QCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEG--SFRCS-CAPGYRAPSGRP 873
Query: 312 THCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDI 371
C+D+NEC D CFP C+NT F C P G + + C D+
Sbjct: 874 GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGAS------------CLDV 921
Query: 372 DECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHA 430
DEC++ + + ICTNT GSF+C C G G CL C P +
Sbjct: 922 DECSEED---LCQSGICTNTDGSFEC-ICPPGHRAGPDLASCLDVDECRE--RGPALCGS 975
Query: 431 HCLFERNGAVSC--QCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKH-CKQDNCLLTP 487
G+ C C+ G+ GT D+D C + C C TP
Sbjct: 976 QRCENSPGSYRCVRDCDPGYHAGPE--GTCDDVD-------ECQEYGPEICGAQRCENTP 1026
Query: 488 NSGQEDADNDGVGDQCD---DDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPN 544
S + CD G G ++V D CR SF A C N
Sbjct: 1027 GSYR-------CTPACDPGYQPTPGGGCQDV-DECR-----------NRSFCGAHAVCQN 1067
Query: 545 VPNNDQKDTDGNGEG 559
+P + Q D EG
Sbjct: 1068 LPGSFQCLCDQGYEG 1082
Score = 52.4 bits (124), Expect = 2e-06
Identities = 56/198 (28%), Positives = 73/198 (36%), Gaps = 36/198 (18%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPG--LQGNGTHCSDINECAHA-DPCFPGSSCIN 334
C P C + GY C C G L GT C D++EC PC PG C N
Sbjct: 556 CGPGRC--------ISRPSGYTCA-CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCEN 605
Query: 335 TMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGS 394
+ F C C G++ RA++ C D+DEC+ CD C NT GS
Sbjct: 606 SPGSFRC-VCGPGFRAG---------PRAAE--CLDVDECH-RVPPPCDLGR-CENTPGS 651
Query: 395 FKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGN 453
F C C G+ C C SP G+ C C G+ G+
Sbjct: 652 FLC-VCPAGYQAAPHGASCQDVDEC---TQSPGLCGRGACKNLPGSFRCVCPAGFRGS-- 705
Query: 454 VCGTDTDIDGYPDQALPC 471
+ D+D + PC
Sbjct: 706 --ACEEDVDECAQEPPPC 721
Score = 49.3 bits (116), Expect = 2e-05
Identities = 88/357 (24%), Positives = 122/357 (34%), Gaps = 70/357 (19%)
Query: 326 CFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPN 385
C PG CI+ G+ C AC G++ +S G C D+DEC C P
Sbjct: 556 CGPGR-CISRPSGYTC-ACDSGFR---LSPQGTR--------CIDVDECRRVPPP-CAPG 601
Query: 386 SICTNTVGSFKCGPCRLGF-LGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQC 444
C N+ GSF+C C GF G ++ CL CH PC + C G+ C C
Sbjct: 602 R-CENSPGSFRC-VCGPGFRAGPRAAECLDVDECHR-VPPPCDL-GRCE-NTPGSFLCVC 656
Query: 445 NVGW--AGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQ 502
G+ A +G C D+D C + C + C P S + G
Sbjct: 657 PAGYQAAPHGASC---QDVD-------ECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSA 706
Query: 503 CDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDAC 562
C++D D C P ++ G CP G G C
Sbjct: 707 CEEDVD---------ECAQEPPPCGPGRCDNTAGSFHCACP-------AGFRSRGPGAPC 750
Query: 563 DNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCD 622
+ +D C + P P R E+ G CP P ++ + V D C+
Sbjct: 751 QD----------VDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDV-DECE 799
Query: 623 TNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDG----LGDECDGDDDNDGIPDYVPPG 675
+ G C P S Q + G G D D+ + G P P G
Sbjct: 800 NHLACPG-------QECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHG 849
Score = 45.8 bits (107), Expect = 2e-04
Identities = 37/104 (35%), Positives = 48/104 (46%), Gaps = 18/104 (17%)
Query: 316 DINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECN 375
+ EC D C G C+ GF C C GY+ +D R + C DI+EC+
Sbjct: 1533 EAEECGILDGCTNGR-CVRVPEGFTCR-CFDGYR--------LDMTRMA---CVDINECD 1579
Query: 376 DGNNGG--CDPNSICTNTVGSFKCGPCRLGFL-GNQSQGCLPAR 416
+ C N+ C NT GSF+C CR GF +Q C PAR
Sbjct: 1580 EAEAASPLC-VNARCLNTDGSFRC-ICRPGFAPTHQPHHCAPAR 1621
Score = 43.9 bits (102), Expect = 7e-04
Identities = 28/83 (33%), Positives = 35/83 (42%), Gaps = 15/83 (18%)
Query: 316 DINECA-HADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDEC 374
D++EC D C+NT PG+ C C GY Y + C D DEC
Sbjct: 1253 DVDECQLFRDQVCKSGVCVNTAPGYSC-YCSNGY-----------YYHTQRLECIDNDEC 1300
Query: 375 NDGNNGGCDPNSICTNTVGSFKC 397
D C+ C NTVGS+ C
Sbjct: 1301 AD-EEPACE-GGRCVNTVGSYHC 1321
Score = 43.5 bits (101), Expect = 0.001
Identities = 20/48 (41%), Positives = 25/48 (52%), Gaps = 2/48 (4%)
Query: 301 GPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGY 348
GPCP G + C D++ECA C G C NT G+ C CP G+
Sbjct: 342 GPCPTGFERVNGSCEDVDECATGGRCQHG-ECANTRGGYTC-VCPDGF 387
Score = 40.4 bits (93), Expect = 0.008
Identities = 28/89 (31%), Positives = 37/89 (41%), Gaps = 15/89 (16%)
Query: 259 IRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGL--QGNGTHCSD 316
+R + ECQ+ F +Q C C V PGY C C G C D
Sbjct: 1250 LRRDVDECQL--FRDQV--CKSGVC--------VNTAPGYSCY-CSNGYYYHTQRLECID 1296
Query: 317 INECAHADPCFPGSSCINTMPGFHCEACP 345
+ECA +P G C+NT+ +HC P
Sbjct: 1297 NDECADEEPACEGGRCVNTVGSYHCTCEP 1325
Score = 38.1 bits (87), Expect = 0.040
Identities = 39/150 (26%), Positives = 54/150 (36%), Gaps = 35/150 (23%)
Query: 283 CFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSD------INECAHADPCFPGSSCINTM 336
CFR E G C PGL+ C +++C S ++
Sbjct: 289 CFR--------ELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAP 340
Query: 337 PGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFK 396
G CP G++ S C D+DEC G G C + C NT G +
Sbjct: 341 DG----PCPTGFERVNGS-------------CEDVDECATG--GRCQ-HGECANTRGGYT 380
Query: 397 CGPCRLGFLGNQSQGCLPARTCHSPAHSPC 426
C C GFL + S+ ++ S A PC
Sbjct: 381 C-VCPDGFLLDSSRSSCISQHVISEAKGPC 409
Score = 33.1 bits (74), Expect = 1.3
Identities = 26/91 (28%), Positives = 36/91 (39%), Gaps = 14/91 (15%)
Query: 264 MECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHA 323
+E + CG + C+ C R + + GYR L C DINEC A
Sbjct: 1532 LEAEECGILDG---CTNGRCVRVPEGFTCRCFDGYR-------LDMTRMACVDINECDEA 1581
Query: 324 DPCFP---GSSCINTMPGFHCEACPRGYKGT 351
+ P + C+NT F C C G+ T
Sbjct: 1582 EAASPLCVNARCLNTDGSFRC-ICRPGFAPT 1611
Score = 31.2 bits (69), Expect = 4.8
Identities = 16/45 (35%), Positives = 20/45 (44%), Gaps = 3/45 (6%)
Query: 303 CPPGLQG--NGTHCSDINECAHADPCFPGSSCINTMPGFHCEACP 345
C G +G +G HC D+NEC + C N F C CP
Sbjct: 1076 CDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLC-VCP 1119
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 75.9 bits (185), Expect = 2e-13
Identities = 60/195 (30%), Positives = 80/195 (41%), Gaps = 32/195 (16%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMP 337
C+P+PC G +C + +Y + C CP G QG T DINEC PC G+SC NT
Sbjct: 833 CAPSPCRNGGECRQSEDYESFSC-VCPTGWQGQ-TCEVDINECV-LSPCRHGASCQNTHG 889
Query: 338 GFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDG-NNGGCD-----PNSICTNT 391
G+ C C GY G ID R + C++ C DG N CD + C
Sbjct: 890 GYRCH-CQAGYSGRNCE-TDIDDCRPNP--CHNGGSCTDGINTAFCDCLPGFRGTFCEED 945
Query: 392 VGSFKCGPCRLGFLGNQSQGCLPARTCHSPA---------------HSPCHIHAHCLFER 436
+ PCR G C+ + TC PA S C C+
Sbjct: 946 INECASDPCR---NGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGI 1002
Query: 437 NGAVSCQCNVGWAGN 451
N + +C C G+ G+
Sbjct: 1003 N-SFTCLCPPGFTGS 1016
Score = 73.9 bits (180), Expect = 7e-13
Identities = 125/515 (24%), Positives = 178/515 (34%), Gaps = 114/515 (22%)
Query: 267 QVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSD-INECAHADP 325
Q C PN C G C + GY C C G G CS+ I++CA A
Sbjct: 290 QYCTEDVDECQLMPNACQNGGTCHNTHG--GYNC-VCVNGWTGED--CSENIDDCASA-A 343
Query: 326 CFPGSSCINTMPGFHCEACPRGYKGTQV------------SGVGIDYARAS-KQVC---- 368
CF G++C + + F+CE CP G G G D + K +C
Sbjct: 344 CFHGATCHDRVASFYCE-CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPS 402
Query: 369 --------NDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQ---------SQG 411
D+DEC+ G N C+ C NT+GSF+C C G+ G + S
Sbjct: 403 GYTGPACSQDVDECSLGAN-PCEHAGKCINTLGSFEC-QCLQGYTGPRCEIDVNECVSNP 460
Query: 412 CLPARTC------------------------HSPAHSPCHIHAHCLFERNGAVSCQCNVG 447
C TC A SPC + CL ++ C+C G
Sbjct: 461 CQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCL-DKINEFQCECPTG 519
Query: 448 WAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDA 507
+ G++C D D + PC + K CL PN+ G C+ D
Sbjct: 520 F--TGHLCQYDVD----ECASTPCKNGAK------CLDGPNTYTCVCTEGYTGTHCEVDI 567
Query: 508 D------------GDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDG 555
D DG+ CR P + +T+ + C + P +D D
Sbjct: 568 DECDPDPCHYGSCKDGVATFTCLCR--PGYTGHHCETNI--NECSSQPCRHGGTCQDRD- 622
Query: 556 NGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDE-DGVGDACDSCPEMSNPTQTDADS 614
N C G LD+C P T D+ DG AC+ P T +
Sbjct: 623 NAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACE-------PGYTGSMC 675
Query: 615 DLVGDVCDTNEDSDG----DGHQDTKDNCPQ-LPNSSQLDSDNDGLGDECDGDDDNDGIP 669
++ D C N +G DG CP+ + + L N+ + C D +
Sbjct: 676 NINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLN 735
Query: 670 DY---VPPGPDNCRLVPNPNQKDSDGNGVGDVCED 701
Y PG N N+ +S+ G C+D
Sbjct: 736 GYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKD 770
Score = 66.2 bits (160), Expect = 1e-10
Identities = 82/322 (25%), Positives = 116/322 (36%), Gaps = 68/322 (21%)
Query: 270 GFHE-----QRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHAD 324
G+H+ + + C+ NPC G C + GY+C C PG +GT+C N ++
Sbjct: 707 GYHDPTCLSEVNECNSNPCVHGA-CRDSLN--GYKCD-CDPGW--SGTNCDINNNECESN 760
Query: 325 PCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDP 384
PC G +C + G+ C C G+ G +I+EC + C
Sbjct: 761 PCVNGGTCKDMTSGYVC-TCREGFSGPNCQ--------------TNINEC---ASNPCLN 802
Query: 385 NSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHC-LFERNGAVSCQ 443
C + V +KC C L + G + L C A SPC C E + SC
Sbjct: 803 QGTCIDDVAGYKCN-CLLPYTGATCEVVL--APC---APSPCRNGGECRQSEDYESFSCV 856
Query: 444 CNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQC 503
C GW G C D + C+L+P N G +C
Sbjct: 857 CPTGW--QGQTCEVDI---------------------NECVLSPCRHGASCQNTHGGYRC 893
Query: 504 DDDADGDGIKNVE---DNCRLFPNK-DQQNSDTDSFGDA-CDNCPNVPNNDQKDTDGNGE 558
A G +N E D+CR PN S TD A CD P ++
Sbjct: 894 HCQAGYSG-RNCETDIDDCR--PNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECA 950
Query: 559 GDACDNDVD-GDGIPNGLDNCP 579
D C N + D + + CP
Sbjct: 951 SDPCRNGANCTDCVDSYTCTCP 972
Score = 65.1 bits (157), Expect = 3e-10
Identities = 120/538 (22%), Positives = 182/538 (33%), Gaps = 131/538 (24%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCS-DINECA-HADPCFPGSSCINT 335
C NPC G +C + G CP G G CS D++EC+ A+PC CINT
Sbjct: 376 CISNPCNEGSNC-DTNPVNGKAICTCPSGYTGPA--CSQDVDECSLGANPCEHAGKCINT 432
Query: 336 MPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSF 395
+ F C+ C +GY G + D++EC + C ++ C + +G F
Sbjct: 433 LGSFECQ-CLQGYTGPRCE--------------IDVNECV---SNPCQNDATCLDQIGEF 474
Query: 396 KCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVC 455
+C C G+ G + + C A SPC + CL + N C+C G+ G+ +C
Sbjct: 475 QC-ICMPGYEGVHCE--VNTDEC---ASSPCLHNGRCLDKIN-EFQCECPTGFTGH--LC 525
Query: 456 GTDTD-------------IDGYPDQALPCMDN--NKHCKQDNCLLTPNSGQEDADNDGVG 500
D D +DG C + HC+ D P+ + DGV
Sbjct: 526 QYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVA 585
Query: 501 D---QCDDDADGDGIKNVEDNCRLFPNK------DQQNSDT-----DSFGDAC----DNC 542
C G + + C P + D+ N+ + G C D+C
Sbjct: 586 TFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDC 645
Query: 543 PNVPNNDQKDTDG-NGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRD-EDGVGDACDS 600
+ P + D +G AC+ G +D C NP EDG+
Sbjct: 646 ASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDEC--AGNPCHNGGTCEDGINGFTCR 703
Query: 601 CPE--------------MSNPT------------QTDADSDLVGDVCDTN---------- 624
CPE SNP + D D G CD N
Sbjct: 704 CPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCV 763
Query: 625 -----------------EDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDG 667
E G Q + C P +Q +D G +C+
Sbjct: 764 NGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCN------- 816
Query: 668 IPDYVPPGPDNCRLVPNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTD 725
+P C +V P NG +D+++ + V P ++ EV + +
Sbjct: 817 --CLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINE 872
Score = 62.4 bits (150), Expect = 2e-09
Identities = 84/376 (22%), Positives = 133/376 (35%), Gaps = 52/376 (13%)
Query: 276 SHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINT 335
+ C PC G C + YRC CP G G +C ++ + PC G C T
Sbjct: 1023 NECDSQPCLHGGTCQD--GCGSYRC-TCPQGY--TGPNCQNLVHWCDSSPCKNGGKCWQT 1077
Query: 336 MPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSF 395
+ CE CP G+ G + A+++ D+ C +C + +
Sbjct: 1078 HTQYRCE-CPSGWTGLYCDVPSVSCEVAAQRQGVDVARL-------CQHGGLCVDAGNTH 1129
Query: 396 KCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVC 455
C C+ G+ G+ + + C SP SPC A C + G SC+C G+ +G C
Sbjct: 1130 HC-RCQAGYTGSYCEDLVD--EC-SP--SPCQNGATCT-DYLGGYSCKCVAGY--HGVNC 1180
Query: 456 GTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDAD--GDGIK 513
+ D + PC + CL PN+ + G C+ + D +
Sbjct: 1181 SEEID----ECLSHPCQNGG------TCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVD 1230
Query: 514 NVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPN 573
V + + F N + D G CP ++ + D N + N D
Sbjct: 1231 PVSRSPKCFNN----GTCVDQVGGYSCTCPPGFVGERCEGDVN---ECLSNPCDA----R 1279
Query: 574 GLDNCPKVPNPL-------QTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCDTNED 626
G NC + N T R + V + C P + T A + G +C
Sbjct: 1280 GTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAG 1339
Query: 627 SDGDGHQDTKDNCPQL 642
+G ++ C L
Sbjct: 1340 FEGATCENDARTCGSL 1355
Score = 58.2 bits (139), Expect = 4e-08
Identities = 91/401 (22%), Positives = 128/401 (31%), Gaps = 100/401 (24%)
Query: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCS-DINECAHADPCFPGSSCINTM 336
C+ + CF G C++ + C CPPG G++C D+NEC + PC G +C +
Sbjct: 987 CTESSCFNGGTCVDGIN--SFTC-LCPPGF--TGSYCQHDVNEC-DSQPCLHGGTCQDGC 1040
Query: 337 PGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFK 396
+ C CP+GY G N + C ++ C C T ++
Sbjct: 1041 GSYRC-TCPQGYTGPNCQ--------------NLVHWC---DSSPCKNGGKCWQTHTQYR 1082
Query: 397 CGPCRLGFLG-------------NQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQ 443
C C G+ G Q QG AR C H + C+
Sbjct: 1083 C-ECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQ---------HGGLCVDAGNTHHCR 1132
Query: 444 CNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQC 503
C G+ G+ C D C C +G D G G C
Sbjct: 1133 CQAGYTGS------------------YCEDLVDECSPSPC----QNGATCTDYLG-GYSC 1169
Query: 504 DDDADGDGIKNVE--DNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDA 561
A G+ E D C P QN T C ++PN + +G
Sbjct: 1170 KCVAGYHGVNCSEEIDECLSHP---CQNGGT---------CLDLPNTYKCSCPRGTQGVH 1217
Query: 562 CDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVC 621
C+ +VD P +D + P D VG +CP VG+ C
Sbjct: 1218 CEINVDDCNPP--VDPVSRSPKCFNNGTCVDQVGGYSCTCP-----------PGFVGERC 1264
Query: 622 --DTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECD 660
D NE NC Q N + G C+
Sbjct: 1265 EGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCE 1305
Score = 51.2 bits (121), Expect = 5e-06
Identities = 103/457 (22%), Positives = 135/457 (29%), Gaps = 146/457 (31%)
Query: 273 EQRSHCSPNPCFRGVDCM------------------------EVYEYPG----------- 297
+Q C+ NPC G C+ E + PG
Sbjct: 139 QQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNE 198
Query: 298 ---YRC---------------GPCPPGLQGNGTHCSDINECAHADPCFP---GSSC---I 333
YRC PC P NG C + H C P G +C I
Sbjct: 199 VGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENI 258
Query: 334 NTMPGFHCEACPRGYKGTQVSGVGIDYARA----SKQVC-NDIDECNDGNNGGCDPNSIC 388
+ PG +C+ G V GV R + Q C D+DEC N C C
Sbjct: 259 DDCPGNNCK-----NGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPN-ACQNGGTC 312
Query: 389 TNTVGSFKCGPCRLGFLGNQ---------SQGCLPARTCHSPAHS------------PCH 427
NT G + C C G+ G S C TCH S CH
Sbjct: 313 HNTHGGYNC-VCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCH 371
Query: 428 IHAHCLFER------------NGAVSCQCNVGWAGNGNVCGTDTD---IDGYPDQALPCM 472
++ C+ NG C C G+ G C D D + P +
Sbjct: 372 LNDACISNPCNEGSNCDTNPVNGKAICTCPSGY--TGPACSQDVDECSLGANPCEHAGKC 429
Query: 473 DNNKHCKQDNCLLTPNSGQEDAD-NDGVGDQCDDDA-----------------DGDGIKN 514
N + CL + + D N+ V + C +DA +G +
Sbjct: 430 INTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEV 489
Query: 515 VEDNCRLFP-----------NKDQQNSDTDSFGDAC----DNCPNVP-NNDQKDTDG-NG 557
D C P N+ Q T G C D C + P N K DG N
Sbjct: 490 NTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNT 549
Query: 558 EGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGV 594
C G +D C P+P +DGV
Sbjct: 550 YTCVCTEGYTGTHCEVDIDECD--PDPCHYGSCKDGV 584
Score = 32.3 bits (72), Expect = 2.2
Identities = 44/170 (25%), Positives = 56/170 (32%), Gaps = 37/170 (21%)
Query: 305 PGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARAS 364
P L G CS PG +C+N G CEA GT+ G +
Sbjct: 15 PALAARGPRCSQ-----------PGETCLN---GGKCEAA----NGTEACVCGGAFVGPR 56
Query: 365 KQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHS 424
Q N N G C + + V + C C LGF G CL ++ +
Sbjct: 57 CQDPNPCLSTPCKNAGTC--HVVDRRGVADYACS-CALGFSGPL---CLTPLD-NACLTN 109
Query: 425 PCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDN 474
PC C C+C GW+G C QA PC N
Sbjct: 110 PCRNGGTCDLLTLTEYKCRCPPGWSGKS--C----------QQADPCASN 147
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 75.5 bits (184), Expect = 2e-13
Identities = 60/207 (28%), Positives = 86/207 (41%), Gaps = 45/207 (21%)
Query: 278 CSPNPCFRGVDCMEVYE--------YPGYRCGP------------CPPG-LQGNGTHCSD 316
C P + +C +V E PG+ C C G LQ +C D
Sbjct: 751 CEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVD 810
Query: 317 INECAH-ADPCFPGSSCINTMPGFHCE----ACPRGYKGTQVSGVGIDYARASKQVCNDI 371
INEC ++PC PG SCINT+ + C+ C RGY +A C D+
Sbjct: 811 INECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGY-----------HASDDGTKCVDV 859
Query: 372 DECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQ-SQGCLPARTCHSPAHSPCHIHA 430
+EC G + C +C N GS++C C+ GF + +GC+ C + SP +
Sbjct: 860 NECETGVH-RCGEGQVCHNLPGSYRC-DCKAGFQRDAFGRGCIDVNECWA---SPGRLCQ 914
Query: 431 HCLFERNGAVSCQCNVGW--AGNGNVC 455
H G+ C C G+ A +G C
Sbjct: 915 HTCENTLGSYRCSCASGFLLAADGKRC 941
Score = 75.1 bits (183), Expect = 3e-13
Identities = 56/176 (31%), Positives = 69/176 (39%), Gaps = 26/176 (14%)
Query: 280 PNPCFRGVDCMEVYE-YPGYRCGPCPPG--LQGNGTHCSDINECA-HADPCFPGSSCINT 335
PN C C +V G C PG + +G C DINEC C G C+NT
Sbjct: 680 PNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNT 739
Query: 336 MPGFHCE---ACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTV 392
+ FHC C GY C D+DEC G + C P +C NT
Sbjct: 740 LGSFHCYKALTCEPGY-------------ALKDGECEDVDECAMGTH-TCQPGFLCQNTK 785
Query: 393 GSFKCGP---CRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCN 445
GSF C C GFL + C+ C S PC C+ G+ +CQ N
Sbjct: 786 GSFYCQARQRCMDGFLQDPEGNCVDINECTS-LSEPCRPGFSCI-NTVGSYTCQRN 839
Score = 53.1 bits (126), Expect = 1e-06
Identities = 40/128 (31%), Positives = 56/128 (43%), Gaps = 21/128 (16%)
Query: 273 EQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQ--GNGTHCSDINECAHADPCFPGS 330
E + C C + +C +Y Y+C C G Q +G C+DI+ECA
Sbjct: 942 EDVNECEAQRCSQ--ECANIYG--SYQCY-CRQGYQLAEDGHTCTDIDECAQGAGILCTF 996
Query: 331 SCINTMPGFHCEACP-RGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICT 389
C+N + C ACP +GY T A+ + C D+DEC G + C C
Sbjct: 997 RCLNVPGSYQC-ACPEQGYTMT-----------ANGRSCKDVDECALGTH-NCSEAETCH 1043
Query: 390 NTVGSFKC 397
N GSF+C
Sbjct: 1044 NIQGSFRC 1051
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.138 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,519,854
Number of Sequences: 37866
Number of extensions: 2383575
Number of successful extensions: 8943
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 212
Number of HSP's that attempted gapping in prelim test: 6168
Number of HSP's gapped (non-prelim): 1332
length of query: 956
length of database: 18,247,518
effective HSP length: 112
effective length of query: 844
effective length of database: 14,006,526
effective search space: 11821507944
effective search space used: 11821507944
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.